UnificationXref8085
type: UnificationXref
id: 3670522
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670522

UnificationXref8084
type: UnificationXref
id: 3670521
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670521

UnificationXref8083
type: UnificationXref
id: 3670520
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670520

UnificationXref8082
type: UnificationXref
id: REACT_16090
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16090.2

UnificationXref8089
type: UnificationXref
id: REACT_114105
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114105.8

Homologues of ACSS1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P52910
xref: UnificationXref6429
cellular location: GO:0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3671148

UnificationXref8088
type: UnificationXref
id: 3673456
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673456

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q01574
data source: Provenance1
name: Acetyl-coenzyme A synthetase 2-like, mitochondrial
name: acyl-CoA synthetase short-chain family member 1
name: Q01574
xref: UnificationXref6426
feature: FragmentFeature1053
cellular location: GO:0005759
comment: Reactome DB_ID: 3671143
display name: ACSS1

UnificationXref8087
type: UnificationXref
id: REACT_101752
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101752.9

P52910
type: Protein
entity reference: P52910
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Acetyl-coenzyme A synthetase 2-like, mitochondrial
name: acyl-CoA synthetase short-chain family member 1
xref: UnificationXref6428
feature: FragmentFeature1054
cellular location: GO:0005759
comment: Reactome DB_ID: 3671147
display name: ACSS1

UnificationXref8086
type: UnificationXref
id: 3670524
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670524

Homologues of ALDH1A1
type: Protein
data source: Provenance1
member physical entity: ALDH1A1
member physical entity: P54115
xref: UnificationXref6439
cellular location: GO:0005829
comment: Reactome DB_ID: 3666723
comment: Converted from EntitySet in Reactome

Protoporphyrinogen oxidase
type: Protein
entity reference: P40012
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P40012
name: PPOX_HUMAN
xref: UnificationXref6374
feature: FragmentFeature1049
cellular location: GO:0005758
comment: Reactome DB_ID: 3669177
display name: PPOX

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P16622
data source: Provenance1
name: Ferrochelatase
name: P16622
name: HEMZ_HUMAN
xref: UnificationXref6387
feature: FragmentFeature1050
cellular location: GO:0005759
comment: Reactome DB_ID: 3669210
display name: FECH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P21592
data source: Provenance1
name: Protoheme IX farnesyltransferase, mitochondrial ecNumber2.5.1.-/ecNumber
name: COX10(?-443)
name: COX10_HUMAN
name: P21592
xref: UnificationXref6400
feature: FragmentFeature1051
cellular location: GO:0005743
comment: Reactome DB_ID: 3673013
display name: COX10

P40086
type: Protein
entity reference: P40086
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: COX15_HUMAN
name: Cytochrome c oxidase assembly protein COX15 homolog
xref: UnificationXref6407
feature: FragmentFeature1052
cellular location: GO:0005743
comment: Reactome DB_ID: 3673019
display name: COX15

UnificationXref8081
type: UnificationXref
id: 382571
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=382571

SequenceSite1040
type: SequenceSite
position status: EQUAL
sequence position: 322

UnificationXref8080
type: UnificationXref
id: REACT_16095
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16095.2

SequenceSite1042
type: SequenceSite
position status: EQUAL
sequence position: 1220

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P32347
data source: Provenance1
name: DCUP_HUMAN
name: Uroporphyrinogen III decarboxylase
name: P32347
xref: UnificationXref6342
feature: FragmentFeature1047
cellular location: GO:0005829
comment: Reactome DB_ID: 3669184
display name: UROD

SequenceSite1041
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P11353
data source: Provenance1
name: HEM6_HUMAN
name: P11353
name: Coproporphyrinogen III oxidase, mitochondrial
name: CPOX(132-454)
xref: UnificationXref6366
feature: FragmentFeature1048
cellular location: GO:0005758
comment: Reactome DB_ID: 3669170
display name: CPOX

SequenceSite1032
type: SequenceSite
position status: EQUAL
sequence position: 1268

SequenceSite1033
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1034
type: SequenceSite
position status: EQUAL
sequence position: 1094

SequenceSite1035
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1036
type: SequenceSite
position status: EQUAL
sequence position: 1032

SequenceSite1037
type: SequenceSite
position status: EQUAL
sequence position: 1

Downstream signaling of activated FGFR
type: Pathway
data source: Provenance1
pathway component: REACT 131614.5
pathway component: REACT 108755.9
pathway component: REACT 114011.8
evidence: Evidence212
xref: UnificationXref2141
xref: UnificationXref2140
pathway order: PathwayStep211
pathway order: PathwayStep212
pathway order: PathwayStep213
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite1038
type: SequenceSite
position status: EQUAL
sequence position: 198

SequenceSite1039
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref8079
type: UnificationXref
id: 382577
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=382577

UnificationXref8094
type: UnificationXref
id: REACT_106955
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106955.9

UnificationXref8093
type: UnificationXref
id: 3670514
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670514

UnificationXref8096
type: UnificationXref
id: REACT_129804
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129804.5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P06174
data source: Provenance1
name: HEM4_HUMAN
name: Uroporphyrinogen-III synthase
name: P06174
xref: UnificationXref6335
feature: FragmentFeature1046
cellular location: GO:0005829
comment: Reactome DB_ID: 3669218
display name: UROS

UnificationXref8095
type: UnificationXref
id: 3673473
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673473

UnificationXref8098
type: UnificationXref
id: 1454930
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1454930

P05373
type: Protein
entity reference: P05373
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: HEM2_HUMAN
name: Delta-aminolevulinic acid dehydratase
xref: UnificationXref6305
feature: FragmentFeature1044
cellular location: GO:0005829
comment: Reactome DB_ID: 3669191
display name: ALAD

UnificationXref8097
type: UnificationXref
id: CHEBI:25696
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P28789
data source: Provenance1
name: HEM3_HUMAN
name: P28789
name: Porphobilinogen deaminase
xref: UnificationXref6324
feature: FragmentFeature1045
cellular location: GO:0005829
comment: Reactome DB_ID: 3669163
display name: HMBS

5-aminolevulinate synthase, non-specific (pyridoxal phosphate cofactor)
type: Protein
entity reference: P09950
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P09950
name: PXLP-ALAS1
name: 5-aminolevulinate synthase, non-specific, mitochondrial
name: HEM1_HUMAN
xref: UnificationXref6294
feature: FragmentFeature1042
feature: ModificationFeature167
cellular location: GO:0005759
comment: Reactome DB_ID: 3669199
display name: ALAS1

UnificationXref8099
type: UnificationXref
id: REACT_111889
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111889.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P09950
data source: Provenance1
name: 5-aminolevulinate synthase, erythroid (pyridoxal phosphate cofactor)
name: 5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor
name: P09950
name: HEM0_HUMAN
name: PXLP-ALAS2
xref: UnificationXref6296
feature: FragmentFeature1043
feature: ModificationFeature167
cellular location: GO:0005759
comment: Reactome DB_ID: 3669201
display name: ALAS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P31373
data source: Provenance1
name: Cystathionine gamma-lyase
name: P31373
xref: UnificationXref6240
feature: FragmentFeature1040
cellular location: GO:0005829
comment: Reactome DB_ID: 3672242
display name: CTH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P43616
data source: Provenance1
name: P43616
name: CNDP2_HUMAN
name: Cytosolic non-specific dipeptidase
xref: UnificationXref6250
feature: FragmentFeature1041
cellular location: GO:0005829
comment: Reactome DB_ID: 3672016
display name: CNDP2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P39954
data source: Provenance1
name: P39954
name: SAH hydrolase
xref: UnificationXref6223
feature: FragmentFeature1038
cellular location: GO:0005829
comment: Reactome DB_ID: 3669091
display name: AHCY

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32582
data source: Provenance1
name: PXLP-CBS(2-550)
name: P32582
name: Cystathionine beta-synthase
xref: UnificationXref6232
feature: FragmentFeature1039
feature: ModificationFeature166
cellular location: GO:0005829
comment: Reactome DB_ID: 3672234
display name: CBS

UnificationXref8090
type: UnificationXref
id: 3670510
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670510

SequenceSite1031
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1030
type: SequenceSite
position status: EQUAL
sequence position: 1268

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P19358
data source: Provenance1
name: MAT I/III
name: P19358
xref: UnificationXref6211
feature: FragmentFeature1037
cellular location: GO:0005829
comment: Reactome DB_ID: 3669072
display name: MAT1A

UnificationXref8092
type: UnificationXref
id: 3670512
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670512

UnificationXref8091
type: UnificationXref
id: 3670511
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670511

SequenceSite1023
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1024
type: SequenceSite
position status: EQUAL
sequence position: 765

SequenceSite1021
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1022
type: SequenceSite
position status: EQUAL
sequence position: 198

SequenceSite1027
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1028
type: SequenceSite
position status: EQUAL
sequence position: 1093

SequenceSite1025
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1026
type: SequenceSite
position status: EQUAL
sequence position: 1093

http://identifiers.org/pubmed/10676816
type: PublicationXref
id: 10676816
author: Cerione, RA
author: Nassar, N
author: Hoffman, GR
db: Pubmed
title: Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI
source: Cell 100:345-56
year: 2000

SequenceSite1029
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8067
type: UnificationXref
id: 3673445
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673445

UnificationXref8066
type: UnificationXref
id: REACT_78480
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78480.9

UnificationXref8065
type: UnificationXref
id: 3673444
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673444

UnificationXref8064
type: UnificationXref
id: REACT_152667
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152667.3

UnificationXref8063
type: UnificationXref
id: 3670044
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670044

UnificationXref8062
type: UnificationXref
id: REACT_152884
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152884.3

UnificationXref8061
type: UnificationXref
id: 3670043
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670043

UnificationXref8060
type: UnificationXref
id: REACT_114074
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114074.8

SequenceSite1020
type: SequenceSite
position status: EQUAL
sequence position: 765

SequenceSite1014
type: SequenceSite
position status: EQUAL
sequence position: 1268

SequenceSite1015
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1016
type: SequenceSite
position status: EQUAL
sequence position: 1094

SequenceSite1017
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1010
type: SequenceSite
position status: EQUAL
sequence position: 1093

SequenceSite1011
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1012
type: SequenceSite
position status: EQUAL
sequence position: 1268

http://identifiers.org/pubmed/18414735
type: PublicationXref
id: 18414735
author: Kufer, TA
db: Pubmed
title: Signal transduction pathways used by NLR-type innate immune receptors
source: Mol Biosyst 4:380-6
year: 2008

SequenceSite1013
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8059
type: UnificationXref
id: 3673247
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673247

SequenceSite1018
type: SequenceSite
position status: EQUAL
sequence position: 1032

SequenceSite1019
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8057
type: UnificationXref
id: 3673246
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673246

UnificationXref8058
type: UnificationXref
id: REACT_109369
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_109369.9

http://identifiers.org/pubmed/642006
type: PublicationXref
id: 642006
author: Gall, JG
author: Blackburn, EH
db: Pubmed
title: A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena
source: J Mol Biol 120:33-53
year: 1978

UnificationXref8076
type: UnificationXref
id: REACT_98319
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98319.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q12056
data source: Provenance1
name: ISCU_HUMAN
name: ISCU, mitochondrial
name: ISCU-1
name: Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
name: Q12056
name: ISCU isoform 1
xref: UnificationXref6541
feature: FragmentFeature1062
cellular location: GO:0005759
comment: Reactome DB_ID: 3672041
display name: ISCU2

UnificationXref8075
type: UnificationXref
id: 3673504
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673504

UnificationXref8078
type: UnificationXref
id: REACT_78815
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78815.9

Homologues of ISCU-1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref6542
cellular location: GO:0005759
comment: Reactome DB_ID: 3672042
comment: Converted from EntitySet in Reactome

UnificationXref8077
type: UnificationXref
id: 3673505
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673505

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q03020
data source: Provenance1
name: Q03020
name: ISCU_HUMAN
name: ISCU, mitochondrial
name: ISCU-1
name: Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
name: ISCU isoform 1
xref: UnificationXref6539
feature: FragmentFeature1061
cellular location: GO:0005759
comment: Reactome DB_ID: 3672037
display name: ISCU2

UnificationXref8072
type: UnificationXref
id: REACT_158381
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158381.3

UnificationXref8071
type: UnificationXref
id: 3673564
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673564

UnificationXref8074
type: UnificationXref
id: REACT_130455
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130455.5

UnificationXref8073
type: UnificationXref
id: 3673248
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673248

ALDH1A1
type: Protein
entity reference: P40047
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Aldehyde dehydrogenase, cytosolic
name: Aldehyde dehydrogenase 1A1
name: P40047
name: ALDH-E1
name: ALDH class 1
xref: UnificationXref6437
feature: FragmentFeature1056
cellular location: GO:0005829
comment: Reactome DB_ID: 3666718
display name: ALHDII

P54115
type: Protein
entity reference: P54115
data source: Provenance1
name: ALDH1A1
name: Note: the coordinates are copied over from Homo sapiens.
name: Aldehyde dehydrogenase, cytosolic
name: Aldehyde dehydrogenase 1A1
name: ALDH-E1
name: ALDH class 1
xref: UnificationXref6438
feature: FragmentFeature1057
cellular location: GO:0005829
comment: Reactome DB_ID: 3666722
display name: ALHDII

UnificationXref8070
type: UnificationXref
id: REACT_159848
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159848.3

ALDH1A1
type: Protein
entity reference: P46367
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P46367
name: Aldehyde dehydrogenase, cytosolic
name: Aldehyde dehydrogenase 1A1
name: ALDH-E1
name: ALDH class 1
xref: UnificationXref6436
feature: FragmentFeature1055
cellular location: GO:0005829
comment: Reactome DB_ID: 3666714
display name: ALHDII

MRS3_YEAST
type: Protein
entity reference: P10566
data source: Provenance1
name: Mitochondrial RNA-splicing protein MRS3
xref: UnificationXref6530
xref: UnificationXref6529
feature: FragmentFeature1059
cellular location: GO:0005743
comment: Reactome DB_ID: 2466323
display name: MRS3

Mitochondrial RNA-splicing protein MRS4
type: Protein
entity reference: P23500
data source: Provenance1
name: MRS4_YEAST
xref: UnificationXref6533
xref: UnificationXref6532
feature: FragmentFeature1060
cellular location: GO:0005743
comment: Reactome DB_ID: 2466294
display name: MRS4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q08220
data source: Provenance1
name: GSS(2-474)
name: Glutathione synthase
xref: UnificationXref6457
feature: FragmentFeature1058
cellular location: GO:0005829
comment: Reactome DB_ID: 3669083
display name: Q08220

MRS3/4
type: Protein
data source: Provenance1
member physical entity: Mitochondrial RNA-splicing protein MRS4
member physical entity: MRS3_YEAST
xref: UnificationXref6535
xref: UnificationXref6534
cellular location: GO:0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2466280

SequenceSite1005
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1006
type: SequenceSite
position status: EQUAL
sequence position: 217

SequenceSite1003
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1004
type: SequenceSite
position status: EQUAL
sequence position: 406

SequenceSite1001
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1002
type: SequenceSite
position status: EQUAL
sequence position: 407

SequenceSite1000
type: SequenceSite
position status: EQUAL
sequence position: 208

UnificationXref8068
type: UnificationXref
id: REACT_90418
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90418.9

SequenceSite1009
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8069
type: UnificationXref
id: 3671945
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671945

SequenceSite1007
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1008
type: SequenceSite
position status: EQUAL
sequence position: 1093

UnificationXref8040
type: UnificationXref
id: REACT_156576
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156576.3

UnificationXref8041
type: UnificationXref
id: 3673370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673370

UnificationXref8044
type: UnificationXref
id: 3671168
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671168

UnificationXref8045
type: UnificationXref
id: 3671169
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671169

UnificationXref8042
type: UnificationXref
id: REACT_157998
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157998.3

UnificationXref8043
type: UnificationXref
id: 3671165
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671165

UnificationXref8038
type: UnificationXref
id: 3671182
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671182

UnificationXref8037
type: UnificationXref
id: 3671181
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671181

UnificationXref8036
type: UnificationXref
id: 3671180
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671180

UnificationXref8035
type: UnificationXref
id: 3669351
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669351

UnificationXref8039
type: UnificationXref
id: 3671183
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671183

http://identifiers.org/pubmed/9438390
type: PublicationXref
id: 9438390
author: Webster, MK
author: Bardwell, WM
author: Meyer, AN
author: Donoghue, DJ
author: Robertson, SC
author: d'Avis, PY
db: Pubmed
title: Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I
source: Cell Growth Differ 9:71-8
year: 1998

Arachidonic acid metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 156514.3
pathway component: BiochemicalReaction358
pathway component: REACT 154817.3
pathway component: BiochemicalReaction359
pathway component: BiochemicalReaction357
evidence: Evidence570
xref: RelationshipXref478
xref: UnificationXref4563
xref: UnificationXref4562
pathway order: PathwayStep563
pathway order: PathwayStep565
pathway order: PathwayStep567
pathway order: PathwayStep564
pathway order: PathwayStep566
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8050
type: UnificationXref
id: REACT_138364
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138364.5

UnificationXref8051
type: UnificationXref
id: 3673521
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673521

UnificationXref8052
type: UnificationXref
id: REACT_131769
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131769.5

UnificationXref8053
type: UnificationXref
id: 3673266
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673266

UnificationXref8054
type: UnificationXref
id: REACT_85645
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85645.9

UnificationXref8055
type: UnificationXref
id: 3673274
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673274

UnificationXref8056
type: UnificationXref
id: REACT_102886
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102886.9

UnificationXref8047
type: UnificationXref
id: 3671171
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671171

UnificationXref8046
type: UnificationXref
id: 3671170
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671170

UnificationXref8049
type: UnificationXref
id: 3671173
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671173

UnificationXref8048
type: UnificationXref
id: 3671172
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671172

http://identifiers.org/pubmed/9188485
type: PublicationXref
id: 9188485
author: Folk, JE
author: Park, MH
author: Wolff, EC
db: Pubmed
title: Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase
source: J Biol Chem 272:15865-71
year: 1997

RPC5
type: ProteinReference
name: YPR110C
name: RPC40
name: UniProt:P07703 RPC40
name: P8283.18
name: RPA5
xref: UnificationXref6974
comment: SUBUNIT Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively. Interacts with the RPC19/RPAC2 and RPC53/RPC4.MISCELLANEOUS Present with 13000 molecules/cell in log phase SD medium.SIMILARITY Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
organism: BioSource1

UnificationXref8022
type: UnificationXref
id: 3668885
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668885

UnificationXref8023
type: UnificationXref
id: 3668886
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668886

UnificationXref8020
type: UnificationXref
id: P32485
db: UniProt

UnificationXref8021
type: UnificationXref
id: 3668884
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668884

UnificationXref8019
type: UnificationXref
id: REACT_107268
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107268.9

UnificationXref8018
type: UnificationXref
id: 3673338
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673338

UnificationXref8017
type: UnificationXref
id: REACT_138607
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138607.5

UnificationXref8016
type: UnificationXref
id: 3673535
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673535

UnificationXref8015
type: UnificationXref
id: REACT_142125
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142125.5

UnificationXref8014
type: UnificationXref
id: 3673560
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673560

UnificationXref8013
type: UnificationXref
id: REACT_128300
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128300.5

http://identifiers.org/pubmed/8541526
type: PublicationXref
id: 8541526
author: Park, JG
author: Hunter, S
author: Schreiber, AD
author: Indik, ZK
db: Pubmed
title: The molecular dissection of Fc gamma receptor mediated phagocytosis
source: Blood 86:4389-99
year: 1995

UnificationXref8031
type: UnificationXref
id: 3668906
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668906

UnificationXref8032
type: UnificationXref
id: 3668907
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668907

UnificationXref8033
type: UnificationXref
id: 3668909
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668909

UnificationXref8034
type: UnificationXref
id: REACT_153798
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153798.3

UnificationXref8030
type: UnificationXref
id: 3668903
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668903

http://identifiers.org/pubmed/8631325
type: PublicationXref
id: 8631325
author: Peng, HL
author: Chao, YC
author: Chang, HY
author: Duggleby, RG
author: Huang, JG
db: Pubmed
title: Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli.
source: Eur J Biochem 235:173-9
year: 1996

UnificationXref8029
type: UnificationXref
id: P08018
db: UniProt

UnificationXref8028
type: UnificationXref
id: 3668897
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668897

UnificationXref8025
type: UnificationXref
id: 3668890
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668890

UnificationXref8024
type: UnificationXref
id: 3668887
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668887

UnificationXref8027
type: UnificationXref
id: 3668896
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668896

UnificationXref8026
type: UnificationXref
id: 3668893
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668893

Lagging Strand Synthesis
type: Pathway
data source: Provenance1
pathway component: REACT 89784.9
pathway component: REACT 107359.9
evidence: Evidence109
xref: UnificationXref1225
xref: UnificationXref1224
pathway order: PathwayStep113
pathway order: PathwayStep110
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/8645003
type: PublicationXref
id: 8645003
author: Hara, A
author: Bunai, Y
author: Ohya, I
author: Deyashiki, Y
author: Matsuura, K
db: Pubmed
title: Aldose reductase is a major reductase for isocaproaldehyde, a product of side-chain cleavage of cholesterol, in human and animal adrenal glands
source: Arch Biochem Biophys 328:265-71
year: 1996

M Phase
type: Pathway
data source: Provenance1
pathway component: REACT 157230.3
pathway component: Mitotic Prophase
pathway component: Mitotic Prometaphase
evidence: Evidence32
xref: UnificationXref212
xref: RelationshipXref26
xref: UnificationXref213
pathway order: PathwayStep23
pathway order: PathwayStep27
pathway order: PathwayStep18
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Q08645
type: Protein
entity reference: Q08645
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Folylpolyglutamate synthase-1
name: FOLC_HUMAN
xref: UnificationXref5717
feature: FragmentFeature985
cellular location: GO:0005759
comment: Reactome DB_ID: 3669791
display name: FPGS-1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P40464
data source: Provenance1
name: SLC25A32
name: Mitochondrial folate transporter
xref: UnificationXref5710
feature: FragmentFeature984
cellular location: GO:0005743
comment: Reactome DB_ID: 3669787
display name: P40464

Q08645
type: Protein
entity reference: Q08645
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Folylpolyglutamate synthase-2
name: FPGS isoform 2
name: FOLC_HUMAN
xref: UnificationXref5696
feature: FragmentFeature983
cellular location: GO:0005829
comment: Reactome DB_ID: 3669631
display name: FPGS-2

DHFR
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5687
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3669638

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q06178
data source: Provenance1
name: Nicotinamide mononucleotide adenylyltransferase 3
name: Q06178
xref: UnificationXref5672
feature: FragmentFeature981
cellular location: GO:0005829
comment: Reactome DB_ID: 3669744
display name: NMNAT3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38795
data source: Provenance1
name: NADSYN1
name: NADE1_HUMAN
name: Glutamine-dependent NAD(+) synthetase
xref: UnificationXref5678
feature: FragmentFeature982
cellular location: GO:0005829
comment: Reactome DB_ID: 3669624
display name: P38795

Homologues of NMNAT3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5673
cellular location: GO:0005829
comment: Reactome DB_ID: 3669745
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P53204
data source: Provenance1
name: P53204
name: Nicotinamide mononucleotide adenylyltransferase 3
xref: UnificationXref5671
feature: FragmentFeature980
cellular location: GO:0005829
comment: Reactome DB_ID: 3669743
display name: NMNAT3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P53204
data source: Provenance1
name: P53204
name: Nicotinamide mononucleotide adenylyltransferase 2
name: NMA2_HUMAN
xref: UnificationXref5663
feature: FragmentFeature978
cellular location: GO:0000139
comment: Reactome DB_ID: 3669606
display name: NMNAT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q06178
data source: Provenance1
name: Nicotinamide mononucleotide adenylyltransferase 2
name: Q06178
name: NMA2_HUMAN
xref: UnificationXref5664
feature: FragmentFeature979
cellular location: GO:0000139
comment: Reactome DB_ID: 3669610
display name: NMNAT2

http://identifiers.org/pubmed/19443651
type: PublicationXref
id: 19443651
author: Wang, Jianghai
author: Fukui, Lisa
author: Lee, Brian
author: Cai, Sheng
author: Chen, Yuan
author: Hu, Weidong
db: Pubmed
title: Conformational transition associated with E1-E2 interaction in small ubiquitin-like modifications
source: J. Biol. Chem. 284:20340-8
year: 2009

http://identifiers.org/pubmed/16738315
type: PublicationXref
id: 16738315
author: Lee, Hsiang-Ying
author: Gill, Grace
author: Catic, Andre
author: Di Bacco, A
author: Ouyang, Jian
author: Ploegh, Hidde
db: Pubmed
title: The SUMO-specific protease SENP5 is required for cell division
source: Mol. Cell. Biol. 26:4489-98
year: 2006

http://identifiers.org/pubmed/19957260
type: PublicationXref
id: 19957260
author: Lambert, DM
author: Ferrer, JL
author: Bauvois, C
author: Wouters, J
author: Borel, F
author: Labar, G
db: Pubmed
title: Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling
source: Chembiochem 11:218-27
year: 2010

SequenceSite1098
type: SequenceSite
position status: EQUAL
sequence position: 233

SequenceSite1099
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P33330
data source: Provenance1
name: P33330
xref: UnificationXref5838
feature: FragmentFeature1001
cellular location: GO:0005829
comment: Reactome DB_ID: 3671814
display name: PSAT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P32263
data source: Provenance1
name: pyrroline-5-carboxylate reductase 1
name: P32263
name: P5C reductase
xref: UnificationXref5822
feature: FragmentFeature1000
cellular location: GO:0005759
comment: Reactome DB_ID: 3666304
display name: PYCR1

http://identifiers.org/pubmed/15153069
type: PublicationXref
id: 15153069
author: Lake, S
author: Climent, I
author: Swiezewska, E
author: Forsgren, M
author: Attersand, A
author: Dallner, G
author: Grünler, J
db: Pubmed
title: Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ
source: Biochem J 382:519-26
year: 2004

Homologues of GPT2-1
type: Protein
data source: Provenance1
member physical entity: P52893
member physical entity: P52892
xref: UnificationXref5786
cellular location: GO:0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3671279

P52892
type: Protein
entity reference: P52892
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Alanine aminotransferase 2 isoform 1
xref: UnificationXref5784
feature: FragmentFeature995
feature: ModificationFeature155
cellular location: GO:0005759
comment: Reactome DB_ID: 3671276
display name: GPT2-1

P52892
type: Protein
entity reference: P52892
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Glutamic--pyruvic transaminase
name: PXLP-GPT
name: glutamic-pyruvic transaminase
name: Alanine aminotransferase
name: glutamic-alanine transaminase
xref: UnificationXref5773
feature: FragmentFeature993
feature: ModificationFeature153
cellular location: GO:0005829
comment: Reactome DB_ID: 3666223
display name: GPT

P52893
type: Protein
entity reference: P52893
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Glutamic--pyruvic transaminase
name: PXLP-GPT
name: glutamic-pyruvic transaminase
name: Alanine aminotransferase
name: glutamic-alanine transaminase
xref: UnificationXref5775
feature: FragmentFeature994
feature: ModificationFeature154
cellular location: GO:0005829
comment: Reactome DB_ID: 3666228
display name: GPT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P54885
data source: Provenance1
name: ALDH18A1-1
name: ALDH18A1 long
name: P5CS long
name: Delta-1-pyrroline-5-carboxylate synthetase long
name: ALDH18A1 isoform 1
xref: UnificationXref5808
feature: FragmentFeature998
cellular location: GO:0005743
comment: Reactome DB_ID: 3671300
display name: P54885

ALDH18A1-2
type: Protein
entity reference: P54885
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ALDH18A1 short
name: Delta-1-pyrroline-5-carboxylate synthetase short
name: P5CS short
name: ALDH18A1 isoform 2
xref: UnificationXref5810
feature: FragmentFeature999
cellular location: GO:0005743
comment: Reactome DB_ID: 3671302
display name: P54885

http://identifiers.org/pubmed/11681785
type: PublicationXref
id: 11681785
author: Hruz, PW
author: Mueckler, MM
db: Pubmed
title: Structural analysis of the GLUT1 facilitative glucose transporter (review).
source: Mol Membr Biol 18:183-93
year: 2001

P52893
type: Protein
entity reference: P52893
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Alanine aminotransferase 2 isoform 1
xref: UnificationXref5785
feature: ModificationFeature156
feature: FragmentFeature996
cellular location: GO:0005759
comment: Reactome DB_ID: 3671278
display name: GPT2-1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P07991
data source: Provenance1
name: ornithine-oxo-acid aminotransferase
name: PXLP-OAT(26-439)
name: P07991
name: ornithine aminotransferase, mitochondrial
xref: UnificationXref5801
feature: FragmentFeature997
feature: ModificationFeature157
cellular location: GO:0005759
comment: Reactome DB_ID: 3666297
display name: OAT

ChEBI:28540 5beta-cholestane-3alpha,7alpha,26-triol
type: SmallMoleculeReference
name: 5beta-cholestane-3alpha,7alpha,26-triol
xref: UnificationXref3988

2-Deoxy-D-ribose 1-phosphate
type: SmallMoleculeReference
name: 2-Deoxy-D-ribose 1-phosphate [ChEBI:28542]
xref: UnificationXref5160

SequenceSite1087
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1088
type: SequenceSite
position status: EQUAL
sequence position: 222

SequenceSite1089
type: SequenceSite
position status: EQUAL
sequence position: 2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P25374
data source: Provenance1
name: P25374
name: NSF1 isoform 2
xref: UnificationXref5762
feature: FragmentFeature992
cellular location: GO:0005829
comment: Reactome DB_ID: 3671759
display name: NFS1-2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38820
data source: Provenance1
name: CysS-MOCS3
name: MOCS3-S-S(1-)
xref: UnificationXref5759
feature: FragmentFeature991
feature: ModificationFeature152
cellular location: GO:0005829
comment: Reactome DB_ID: 3671754
display name: P38820

Homologues of PXLP-GPT
type: Protein
data source: Provenance1
member physical entity: P52893
member physical entity: P52892
xref: UnificationXref5776
cellular location: GO:0005829
comment: Reactome DB_ID: 3666229
comment: Converted from EntitySet in Reactome

http://identifiers.org/pubmed/18555844
type: PublicationXref
id: 18555844
author: Buehrer, B
author: Madan, AK
author: Fain, JN
author: Bahouth, SW
author: Tichansky, DS
db: Pubmed
title: Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue
source: Metabolism 57:1005-15
year: 2008

Ketone body metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 87704.9
pathway component: REACT 104363.9
evidence: Evidence386
xref: RelationshipXref300
xref: UnificationXref3437
xref: UnificationXref3438
pathway order: PathwayStep383
pathway order: PathwayStep381
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/15276077
type: PublicationXref
id: 15276077
author: Chimienti, F
author: Seve, M
author: Favier, A
author: Coquerel, Y
author: Pennequin, A
author: Devergnas, S
author: Naud, N
author: Chantegrel, J
db: Pubmed
title: Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study
source: Biochem Pharmacol 68:699-709
year: 2004

http://identifiers.org/pubmed/17266529
type: PublicationXref
id: 17266529
author: Hyde, JE
db: Pubmed
title: Targeting purine and pyrimidine metabolism in human apicomplexan parasites
source: Curr Drug Targets 8:31-47
year: 2007

Homologues of MTHFD1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5727
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3669766

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P09440
data source: Provenance1
name: P09440
xref: UnificationXref5724
feature: FragmentFeature986
cellular location: GO:0005829
comment: Reactome DB_ID: 3669761
display name: MTHFD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P07245
data source: Provenance1
name: P07245
xref: UnificationXref5726
feature: FragmentFeature987
cellular location: GO:0005829
comment: Reactome DB_ID: 3669765
display name: MTHFD1

Homologues of MTHFR
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5745
cellular location: GO:0005829
comment: Reactome DB_ID: 3669780
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P53128
data source: Provenance1
name: Methylenetetrahydrofolate reductase
name: P53128
xref: UnificationXref5742
feature: FragmentFeature988
cellular location: GO:0005829
comment: Reactome DB_ID: 3669775
display name: MTHFR

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P46151
data source: Provenance1
name: Methylenetetrahydrofolate reductase
name: P46151
xref: UnificationXref5744
feature: FragmentFeature989
cellular location: GO:0005829
comment: Reactome DB_ID: 3669779
display name: MTHFR

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38820
data source: Provenance1
name: MOCS3 (red.)
name: P38820
xref: UnificationXref5756
feature: FragmentFeature990
cellular location: GO:0005829
comment: Reactome DB_ID: 3671751
display name: MOCS3

SequenceSite1095
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1094
type: SequenceSite
position status: EQUAL
sequence position: 222

SequenceSite1097
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1096
type: SequenceSite
position status: EQUAL
sequence position: 224

SequenceSite1091
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1090
type: SequenceSite
position status: EQUAL
sequence position: 222

SequenceSite1093
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1092
type: SequenceSite
position status: EQUAL
sequence position: 201

http://identifiers.org/pubmed/12700044
type: PublicationXref
id: 12700044
author: Maness, PF
author: Thelen, K
author: Panicker, AK
author: Buhusi, M
db: Pubmed
title: Cellular signalling mechanisms of neural cell adhesion molecules
source: Front Biosci 8:d900-11
year: 2003

SequenceSite1079
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1078
type: SequenceSite
position status: EQUAL
sequence position: 181

SequenceSite1077
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1076
type: SequenceSite
position status: EQUAL
sequence position: 181

SequenceSite1081
type: SequenceSite
position status: EQUAL
sequence position: 1

SLC25A21
type: Protein
entity reference: Q03028
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Mitochondrial 2-oxodicarboxylate carrier
xref: UnificationXref5950
feature: FragmentFeature1010
cellular location: GO:0005743
comment: Reactome DB_ID: 3670298
display name: Q03028

SequenceSite1082
type: SequenceSite
position status: EQUAL
sequence position: 176

SLC25A21
type: Protein
entity reference: Q99297
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Mitochondrial 2-oxodicarboxylate carrier
xref: UnificationXref5948
feature: FragmentFeature1009
cellular location: GO:0005743
comment: Reactome DB_ID: 3670294
display name: Q99297

SequenceSite1080
type: SequenceSite
position status: EQUAL
sequence position: 76

SequenceSite1085
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1086
type: SequenceSite
position status: EQUAL
sequence position: 258

SequenceSite1083
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1084
type: SequenceSite
position status: EQUAL
sequence position: 386

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P47096
data source: Provenance1
name: 3-hydroxyanthranilic acid dioxygenase
name: 3-HAO
name: 3-hydroxyanthranilate 3,4-dioxygenase
name: 3-hydroxyanthranilate oxygenase
name: P47096
xref: UnificationXref6019
feature: FragmentFeature1017
cellular location: GO:0005829
comment: Reactome DB_ID: 3666474
display name: HAAO

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q05979
data source: Provenance1
name: PXLP-KYNU
name: L-kynurenine hydrolase
name: Q05979
name: kynureninase
xref: UnificationXref6011
feature: FragmentFeature1016
feature: ModificationFeature163
cellular location: GO:0005829
comment: Reactome DB_ID: 3666467
display name: KYNU

BMAL1:CLOCK/NPAS2 Activates Circadian Expression
type: Pathway
data source: Provenance1
pathway component: TemplateReaction32
evidence: Evidence1445
xref: UnificationXref9902
xref: UnificationXref9901
pathway order: PathwayStep1450
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

P38169
type: Protein
entity reference: P38169
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: kynurenine 3-monooxygenase
xref: UnificationXref6004
feature: FragmentFeature1015
cellular location: GO:0005829
comment: Reactome DB_ID: 3666460
display name: KMO

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P47039
data source: Provenance1
name: P47039
name: Kynurenine--oxoglutarate transaminase 3
name: PXLP-CCBL2
name: CCBL2
xref: UnificationXref5996
feature: FragmentFeature1014
feature: ModificationFeature162
cellular location: GO:0005829
comment: Reactome DB_ID: 3671508
display name: KAT3

I23O2_HUMAN
type: Protein
entity reference: P47125
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Indoleamine 2,3-dioxygenase 2
name: P47125
xref: UnificationXref5992
feature: FragmentFeature1013
cellular location: GO:0005829
comment: Reactome DB_ID: 3671477
display name: IDO2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P47125
data source: Provenance1
name: indoleamine 2,3-dioxygenase
name: P47125
xref: UnificationXref5988
feature: FragmentFeature1012
cellular location: GO:0005829
comment: Reactome DB_ID: 3669660
display name: IDO1

PUT2_HUMAN
type: Protein
entity reference: P07275
data source: Provenance1
name: P5C dehydrogenase monomer
name: Note: the coordinates are copied over from Homo sapiens.
name: delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
name: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor
name: P5C dehydrogenase
name: ALDH4A1
xref: UnificationXref5973
feature: FragmentFeature1011
cellular location: GO:0005759
comment: Reactome DB_ID: 3666318
display name: P07275

P09368
type: Protein
entity reference: P09368
data source: Provenance1
xref: UnificationXref5969
cellular location: GO:0005743
comment: Reactome DB_ID: 3666312

Transcription-coupled NER (TC-NER)
type: Pathway
data source: Provenance1
pathway component: REACT 91566.9
pathway component: REACT 30923.10
pathway component: BiochemicalReaction783
pathway component: REACT 30295.10
evidence: Evidence1278
xref: RelationshipXref1098
xref: UnificationXref9070
xref: UnificationXref9069
pathway order: PathwayStep1280
pathway order: PathwayStep1276
pathway order: PathwayStep1283
pathway order: PathwayStep1282
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Homologues of SLC25A21
type: Protein
data source: Provenance1
member physical entity: SLC25A21
xref: UnificationXref5951
cellular location: GO:0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670299

SequenceSite1066
type: SequenceSite
position status: EQUAL
sequence position: 1220

SequenceSite1065
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1068
type: SequenceSite
position status: EQUAL
sequence position: 181

SequenceSite1067
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1069
type: SequenceSite
position status: EQUAL
sequence position: 2

ChEBI:28533 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestanoyl-CoA
type: SmallMoleculeReference
name: 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestanoyl-CoA
xref: UnificationXref3906

SequenceSite1070
type: SequenceSite
position status: EQUAL
sequence position: 181

P42941
type: Protein
entity reference: P42941
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5843
feature: FragmentFeature1002
cellular location: GO:0005829
comment: Reactome DB_ID: 3671807
display name: PSPH

SequenceSite1071
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1072
type: SequenceSite
position status: EQUAL
sequence position: 1859

SequenceSite1073
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1074
type: SequenceSite
position status: EQUAL
sequence position: 1859

SequenceSite1075
type: SequenceSite
position status: EQUAL
sequence position: 2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P47176
data source: Provenance1
name: PXLP-BCAT2
name: P47176
name: branched-chain amino acid aminotransferase, mitochondrial, apoenzyme
xref: UnificationXref5900
feature: FragmentFeature1006
feature: ModificationFeature161
cellular location: GO:0005759
comment: Reactome DB_ID: 3666346
display name: BCAT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38891
data source: Provenance1
name: PXLP-BCAT2
name: P38891
name: branched-chain amino acid aminotransferase, mitochondrial, apoenzyme
xref: UnificationXref5899
feature: FragmentFeature1005
feature: ModificationFeature160
cellular location: GO:0005759
comment: Reactome DB_ID: 3666344
display name: BCAT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38999
data source: Provenance1
name: P38999
name: LKR/SDH
name: lysine-ketoglutarate reductase /saccharopine dehydrogenase monomer
xref: UnificationXref5933
feature: FragmentFeature1008
cellular location: GO:0005759
comment: Reactome DB_ID: 3666367
display name: AASS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P28817
data source: Provenance1
name: HIBCH(32-386)
name: 3-hydroxyisobutyryl-coenzyme A hydrolase
xref: UnificationXref5921
feature: FragmentFeature1007
cellular location: GO:0005759
comment: Reactome DB_ID: 3666361
display name: P28817

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38891
data source: Provenance1
name: PXLP-BCAT1
name: P38891
name: Branched-chain amino acid aminotransferase, cytosolic
xref: UnificationXref5874
feature: FragmentFeature1003
feature: ModificationFeature158
cellular location: GO:0005829
comment: Reactome DB_ID: 3666333
display name: BCAT1

Homologues of PXLP-BCAT1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5877
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3666339

Homologues of PXLP-BCAT2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5901
cellular location: GO:0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3666347

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P47176
data source: Provenance1
name: PXLP-BCAT1
name: Branched-chain amino acid aminotransferase, cytosolic
name: P47176
xref: UnificationXref5876
feature: FragmentFeature1004
feature: ModificationFeature159
cellular location: GO:0005829
comment: Reactome DB_ID: 3666338
display name: BCAT1

SequenceSite1059
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1058
type: SequenceSite
position status: EQUAL
sequence position: 1094

SequenceSite1057
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1056
type: SequenceSite
position status: EQUAL
sequence position: 1268

SequenceSite1055
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1054
type: SequenceSite
position status: EQUAL
sequence position: 1268

SequenceSite1063
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1064
type: SequenceSite
position status: EQUAL
sequence position: 322

SequenceSite1061
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1062
type: SequenceSite
position status: EQUAL
sequence position: 765

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q06489
data source: Provenance1
name: M1PI
name: Q06489
xref: UnificationXref6150
feature: FragmentFeature1031
cellular location: GO:0005829
comment: Reactome DB_ID: 3671980
display name: MRI1

SequenceSite1060
type: SequenceSite
position status: EQUAL
sequence position: 1032

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q07938
data source: Provenance1
name: Q07938
xref: UnificationXref6142
feature: FragmentFeature1030
cellular location: GO:0005829
comment: Reactome DB_ID: 3672009
display name: MTAP

Spermidine synthase
type: Protein
entity reference: UniProt:Q12074
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q12074
xref: UnificationXref6135
feature: FragmentFeature1029
cellular location: GO:0005829
comment: Reactome DB_ID: 3670217
display name: SRM

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P21182
data source: Provenance1
name: AdoMetDC
name: AMD1(1-67)
xref: UnificationXref6125
feature: FragmentFeature1028
cellular location: GO:0005829
comment: Reactome DB_ID: 3670223
display name: P21182

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P43567
data source: Provenance1
name: Alanine-glyoxylate aminotransferase
name: PXLP-AGXT
name: P43567
name: Serine-pyruvate aminotransferase
xref: UnificationXref6202
feature: FragmentFeature1035
feature: ModificationFeature165
cellular location: GO:0005782
comment: Reactome DB_ID: 3670553
display name: AGXT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q03677
data source: Provenance1
name: Q03677
name: ADI1(2-179)
xref: UnificationXref6175
feature: FragmentFeature1034
cellular location: GO:0005829
comment: Reactome DB_ID: 3671988
display name: ARD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32626
data source: Provenance1
name: P32626
name: ENOPH1
xref: UnificationXref6167
feature: FragmentFeature1033
cellular location: GO:0005829
comment: Reactome DB_ID: 3671995
display name: E1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P47095
data source: Provenance1
name: P47095
xref: UnificationXref6159
feature: FragmentFeature1032
cellular location: GO:0005829
comment: Reactome DB_ID: 3672002
display name: APIP

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P10659
data source: Provenance1
name: MAT I/III
name: P10659
xref: UnificationXref6209
feature: FragmentFeature1036
cellular location: GO:0005829
comment: Reactome DB_ID: 3669068
display name: MAT1A

Homologues of MAT1A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref6212
cellular location: GO:0005829
comment: Reactome DB_ID: 3669073
comment: Converted from EntitySet in Reactome

http://identifiers.org/pubmed/10448521
type: PublicationXref
id: 10448521
author: Seetharam, B
db: Pubmed
title: Receptor-mediated endocytosis of cobalamin (vitamin B12)
source: Annu. Rev. Nutr. 19:173-95
year: 1999

SequenceSite1048
type: SequenceSite
position status: EQUAL
sequence position: 198

SequenceSite1047
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9335335
type: PublicationXref
id: 9335335
author: Bell, SP
author: Aparicio, OM
author: Weinstein, DM
db: Pubmed
title: Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase.
source: Cell 91:59-69
year: 1997

SequenceSite1049
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1044
type: SequenceSite
position status: EQUAL
sequence position: 1220

SequenceSite1043
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1046
type: SequenceSite
position status: EQUAL
sequence position: 322

SequenceSite1045
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1050
type: SequenceSite
position status: EQUAL
sequence position: 1093

SequenceSite1051
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1052
type: SequenceSite
position status: EQUAL
sequence position: 1093

SequenceSite1053
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P40360
data source: Provenance1
name: P40360
name: NAGS(19-534)
name: N-acetylglutamate synthetase
xref: UnificationXref6029
feature: FragmentFeature1018
cellular location: GO:0005759
comment: Reactome DB_ID: 3666237
display name: NAGS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P05150
data source: Provenance1
name: ornithine transcarbamylase
name: ornithine carbamoyltransferase, mitochondrial
name: P05150
xref: UnificationXref6055
feature: FragmentFeature1020
cellular location: GO:0005759
comment: Reactome DB_ID: 3666253
display name: OTC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P03965
data source: Provenance1
name: P03965
name: carbamoyl-phosphate synthase (ammonia), mitochondrial
name: carbamoyl-phosphate synthetase I
name: CPSase I
xref: UnificationXref6046
feature: FragmentFeature1019
cellular location: GO:0005759
comment: Reactome DB_ID: 3666245
display name: CPS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P04076
data source: Provenance1
name: arginosuccinase
name: P04076
name: argininosuccinate lyase
xref: UnificationXref6070
feature: FragmentFeature1022
cellular location: GO:0005829
comment: Reactome DB_ID: 3666267
display name: ASL

http://identifiers.org/pubmed/16738331
type: PublicationXref
id: 16738331
author: Itahana, Yoko
author: Yeh, Edward T H
author: Zhang, Yanping
db: Pubmed
title: Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2
source: Mol. Cell. Biol. 26:4675-89
year: 2006

P22768
type: Protein
entity reference: UniProt:P22768
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: argininosuccinic acid synthetase
name: Citrulline--aspartate ligase
name: citrulline-aspartate ligase
name: argininosuccinate synthase
xref: UnificationXref6065
feature: FragmentFeature1021
cellular location: GO:0005829
comment: Reactome DB_ID: 3666274
display name: ASS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P00812
data source: Provenance1
name: Arginase-2, mitochondrial
name: P00812
xref: UnificationXref6086
feature: FragmentFeature1024
cellular location: GO:0005759
comment: Reactome DB_ID: 3671222
display name: ARG2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P00812
data source: Provenance1
name: arginase 1
name: liver-type arginase
name: P00812
name: Arginase 1
xref: UnificationXref6080
feature: FragmentFeature1023
cellular location: GO:0005829
comment: Reactome DB_ID: 3666260
display name: ARG1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P08432
data source: Provenance1
name: Arginine decarboxylase
name: P08432
name: ADC_HUMAN
xref: UnificationXref6110
feature: FragmentFeature1026
cellular location: GO:0005829
comment: Reactome DB_ID: 3670206
display name: ADC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P23180
data source: Provenance1
name: Gamma-BBH
name: P23180
name: gamma-butyrobetaine,2-oxoglutarate dioxygenase
name: gamma-butyrobetaine hydroxylase
xref: UnificationXref6100
feature: FragmentFeature1025
cellular location: GO:0005829
comment: Reactome DB_ID: 3666481
display name: BBOX1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P08432
data source: Provenance1
name: PXLP-ODC1
name: ornithine decarboxylase
name: P08432
xref: UnificationXref6118
feature: ModificationFeature164
feature: FragmentFeature1027
cellular location: GO:0005829
comment: Reactome DB_ID: 3666326
display name: ODC

UnificationXref3874
type: UnificationXref
id: REACT_10414
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10414.1

UnificationXref3875
type: UnificationXref
id: CHEBI:15494
db: ChEBI

UnificationXref3876
type: UnificationXref
id: 193457
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193457

UnificationXref3877
type: UnificationXref
id: REACT_10348
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10348.1

http://identifiers.org/pubmed/7564244
type: PublicationXref
id: 7564244
author: Mooyer, P
author: Wanders, RJ
db: Pubmed
title: D-2-hydroxyglutaric acidaemia: identification of a new enzyme, D-2-hydroxyglutarate dehydrogenase, localized in mitochondria
source: J Inherit Metab Dis 18:194-6
year: 1995

UnificationXref3878
type: UnificationXref
id: 3669346
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669346

UnificationXref3879
type: UnificationXref
id: REACT_113283
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113283.8

UnificationXref3870
type: UnificationXref
id: 3669344
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669344

UnificationXref3871
type: UnificationXref
id: REACT_114941
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114941.8

UnificationXref3872
type: UnificationXref
id: CHEBI:16577
db: ChEBI

UnificationXref3873
type: UnificationXref
id: 193505
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193505

UnificationXref3865
type: UnificationXref
id: REACT_10608
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10608.1

UnificationXref3866
type: UnificationXref
id: CHEBI:37642
db: ChEBI

UnificationXref3863
type: UnificationXref
id: CHEBI:18402
db: ChEBI

UnificationXref3864
type: UnificationXref
id: 192013
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192013

UnificationXref3869
type: UnificationXref
id: 3669342
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669342

http://identifiers.org/pubmed/10970868
type: PublicationXref
id: 10970868
author: Bell, SP
author: Klemm, RD
author: Lee, DG
author: Makhov, AM
db: Pubmed
title: Regulation of origin recognition complex conformation and ATPase activity: differential effects of single-stranded and double-stranded DNA binding.
source: EMBO J 19:4774-82
year: 2000

UnificationXref3867
type: UnificationXref
id: 192096
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192096

UnificationXref3868
type: UnificationXref
id: REACT_10579
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10579.1

http://identifiers.org/pubmed/15519848
type: PublicationXref
id: 15519848
author: Reissmann, S
author: Meyer, AS
author: Frydman, J
author: Spiess, C
db: Pubmed
title: Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets
source: Trends Cell Biol 14:598-604
year: 2004

D-Fructose 2,6-bisphosphate [ChEBI:28602]
type: SmallMoleculeReference
name: D-Fructose 2,6-bisphosphate
xref: UnificationXref2639

UnificationXref3861
type: UnificationXref
id: 3669328
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669328

UnificationXref3862
type: UnificationXref
id: REACT_127661
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127661.5

http://identifiers.org/pubmed/12482854
type: PublicationXref
id: 12482854
author: Horton, JD
author: Moon, YA
db: Pubmed
title: Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade
source: J Biol Chem 278:7335-43
year: 2003

UnificationXref3860
type: UnificationXref
id: REACT_10392
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10392.1

Coproporphyrinogen I
type: SmallMoleculeReference
name: Coproporphyrinogen I [ChEBI:3879]
xref: UnificationXref6349

UnificationXref3856
type: UnificationXref
id: 3669325
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669325

UnificationXref3857
type: UnificationXref
id: REACT_155686
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155686.3

UnificationXref3858
type: UnificationXref
id: CHEBI:28047
db: ChEBI

UnificationXref3859
type: UnificationXref
id: 192030
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192030

http://identifiers.org/pubmed/15534001
type: PublicationXref
id: 15534001
author: Allison, JG
author: Williams, CC
author: Beckman, BS
author: Jones, FE
author: Vidal, GA
author: Burow, ME
author: Marrero, L
db: Pubmed
title: The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
source: J Cell Biol 167:469-78
year: 2004

UnificationXref3852
type: UnificationXref
id: 192087
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192087

UnificationXref3853
type: UnificationXref
id: REACT_10957
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10957.1

UnificationXref3854
type: UnificationXref
id: 3669322
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669322

UnificationXref3855
type: UnificationXref
id: 3669323
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669323

UnificationXref3850
type: UnificationXref
id: REACT_154822
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154822.3

UnificationXref3851
type: UnificationXref
id: CHEBI:16496
db: ChEBI

http://identifiers.org/pubmed/12445829
type: PublicationXref
id: 12445829
author: Visser, WF
author: van Roermund, CW
author: Waterham, HR
author: Wanders, RJ
db: Pubmed
title: Identification of human PMP34 as a peroxisomal ATP transporter
source: Biochem Biophys Res Commun 299:494-7
year: 2002

UnificationXref3847
type: UnificationXref
id: 191980
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191980

UnificationXref3848
type: UnificationXref
id: REACT_10258
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10258.1

UnificationXref3845
type: UnificationXref
id: REACT_10931
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10931.1

UnificationXref3846
type: UnificationXref
id: CHEBI:2290
db: ChEBI

UnificationXref3843
type: UnificationXref
id: CHEBI:17899
db: ChEBI

UnificationXref3844
type: UnificationXref
id: 192136
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192136

PublicationXref1235
type: PublicationXref
id: 0079130356
author: Webster, DR
author: Becroft, DM
author: van Kuilenberg, AB
author: van Gennip, AH
db: ISBN
title: Hereditary orotic aciduria and other disorders of pyrimidine metabolism
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 2663-2704
year: 2001

UnificationXref3841
type: UnificationXref
id: 3669326
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669326

UnificationXref3842
type: UnificationXref
id: REACT_158319
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158319.3

UnificationXref3840
type: UnificationXref
id: 3669319
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669319

UnificationXref3849
type: UnificationXref
id: 3669321
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669321

http://identifiers.org/pubmed/11896061
type: PublicationXref
id: 11896061
author: Hang, Jun
author: Dasso, Mary
db: Pubmed
title: Association of the human SUMO-1 protease SENP2 with the nuclear pore
source: J. Biol. Chem. 277:19961-6
year: 2002

UnificationXref3831
type: UnificationXref
id: REACT_149553
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149553.4

UnificationXref3830
type: UnificationXref
id: 3673596
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673596

UnificationXref3833
type: UnificationXref
id: REACT_148961
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148961.4

UnificationXref3832
type: UnificationXref
id: 3673597
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673597

UnificationXref3835
type: UnificationXref
id: 192195
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192195

UnificationXref3834
type: UnificationXref
id: CHEBI:28477
db: ChEBI

UnificationXref3837
type: UnificationXref
id: CHEBI:2288
db: ChEBI

UnificationXref3836
type: UnificationXref
id: REACT_10471
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10471.1

UnificationXref3838
type: UnificationXref
id: 192064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192064

UnificationXref3839
type: UnificationXref
id: REACT_10393
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10393.1

UnificationXref3822
type: UnificationXref
id: 3672295
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672295

UnificationXref3821
type: UnificationXref
id: 3672294
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672294

UnificationXref3820
type: UnificationXref
id: 3672293
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672293

UnificationXref3826
type: UnificationXref
id: 3672286
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672286

UnificationXref3825
type: UnificationXref
id: 3672285
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672285

UnificationXref3824
type: UnificationXref
id: 3672296
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672296

UnificationXref3823
type: UnificationXref
id: REACT_149184
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149184.4

UnificationXref3829
type: UnificationXref
id: 3672288
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672288

UnificationXref3827
type: UnificationXref
id: 3672287
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672287

UnificationXref3828
type: UnificationXref
id: REACT_149478
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149478.4

PublicationXref1254
type: PublicationXref
id: 0121227022
author: Anderson, EP
db: ISBN
title: Nucleoside and nucleotide kinases
source: The Enzymes, 3rd ed (Book): 49-96
year: 1973

PublicationXref1256
type: PublicationXref
id: 0121227022
author: Noda, L
db: ISBN
title: Adenylate kinase
source: The Enzymes, 3rd ed (Book): 279-305
year: 1973

UnificationXref3813
type: UnificationXref
id: REACT_143103
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143103.5

UnificationXref3812
type: UnificationXref
id: 3672277
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672277

UnificationXref3815
type: UnificationXref
id: 3672301
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672301

UnificationXref3814
type: UnificationXref
id: 3672278
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672278

UnificationXref3811
type: UnificationXref
id: 3672276
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672276

UnificationXref3810
type: UnificationXref
id: 3672260
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672260

UnificationXref3816
type: UnificationXref
id: 3672302
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672302

UnificationXref3817
type: UnificationXref
id: 3672303
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672303

UnificationXref3818
type: UnificationXref
id: REACT_149296
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149296.4

UnificationXref3819
type: UnificationXref
id: 3672304
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672304

http://identifiers.org/pubmed/12474143
type: PublicationXref
id: 12474143
author: Carlson, Christopher G
author: Hoffbuhr, Kristen C
author: Kennaway, Nancy G
author: Glerum, D Moira
author: Antonicka, Hana
author: Leary, Scot C
author: Shoubridge, EA
author: Mattman, Andre
db: Pubmed
title: Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy
source: Am. J. Hum. Genet. 72:101-14
year: 2003

UnificationXref3804
type: UnificationXref
id: P32353
db: UniProt

LYRM4_HUMAN
type: Protein
entity reference: Q6Q560
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: LYRM4 (ISD11)
name: LYR motif-containing protein 4
name: Q6Q560
xref: UnificationXref6549
feature: FragmentFeature1065
cellular location: GO:0005759
comment: Reactome DB_ID: 3672046
display name: LYRM4

UnificationXref3803
type: UnificationXref
id: REACT_10906
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10906.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: YFH1
data source: Provenance1
name: FRDA_HUMAN
name: FXN(81-210)
name: FXN (81-210)
name: Q07540
name: Frataxin, mature
xref: UnificationXref6547
feature: FragmentFeature1064
cellular location: GO:0005759
comment: Reactome DB_ID: 3672049
display name: FXN

UnificationXref3802
type: UnificationXref
id: 195655
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=195655

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q12184
data source: Provenance1
name: Adrenodoxin, mitochondrial
name: Ferredoxin 1
name: ADX_HUMAN
name: Q12184
xref: UnificationXref6562
feature: FragmentFeature1067
cellular location: GO:0005759
comment: Reactome DB_ID: 3672057
display name: FDX1

UnificationXref3801
type: UnificationXref
id: CHEBI:27910
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P48360
data source: Provenance1
name: P48360
name: Ferredoxin reductase
name: ADRO_HUMAN
name: NADPH:adrenodoxin oxidoreductase, mitochondrial
xref: UnificationXref6556
feature: FragmentFeature1066
cellular location: GO:0005759
comment: Reactome DB_ID: 3672806
display name: FDXR

UnificationXref3800
type: UnificationXref
id: REACT_10447
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10447.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P25374
data source: Provenance1
name: P25374
name: Cysteine desulfurase, mitochondrial
name: NFS1, mitochondrial (ISCS)
name: NFS1_HUMAN
name: NSF1 isoform 1
xref: UnificationXref6545
feature: FragmentFeature1063
cellular location: GO:0005759
comment: Reactome DB_ID: 3672051
display name: NFS1-1

Iron-sulfur clusters transporter ATM1, mitochondrial
type: Protein
entity reference: P40416
data source: Provenance1
name: ATM1_YEAST
xref: UnificationXref6638
xref: UnificationXref6637
feature: FragmentFeature1072
cellular location: GO:0005743
comment: Reactome DB_ID: 2564766
display name: ATM1

UnificationXref3809
type: UnificationXref
id: REACT_102561
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102561.9

Astrocytic Glutamate-Glutamine Uptake And Metabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction26
evidence: Evidence62
xref: UnificationXref524
xref: UnificationXref523
pathway order: PathwayStep55
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3807
type: UnificationXref
id: REACT_34697
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34697.10

DRE2_YEAST
type: Protein
entity reference: P36152
data source: Provenance1
name: Fe-S cluster assembly protein DRE2
xref: UnificationXref6598
xref: UnificationXref6597
feature: FragmentFeature1068
cellular location: GO:0005829
comment: Reactome DB_ID: 2564777
display name: DRE2

UnificationXref3808
type: UnificationXref
id: 3673392
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673392

Probable NADPH reductase TAH18 ecNumber1.-.-.-/ecNumber
type: Protein
entity reference: TAH18
data source: Provenance1
name: TAH18_YEAST
xref: UnificationXref6607
xref: UnificationXref6608
feature: FragmentFeature1069
cellular location: GO:0005829
comment: Reactome DB_ID: 2564779
display name: TAH18

UnificationXref3805
type: UnificationXref
id: 3669542
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669542

Cytosolic Fe-S cluster assembly factor NBP35
type: Protein
entity reference: P52920
data source: Provenance1
name: NBP35_YEAST
xref: UnificationXref6622
xref: UnificationXref6623
feature: FragmentFeature1070
cellular location: GO:0005829
comment: Reactome DB_ID: 2564762
display name: NBP35

UnificationXref3806
type: UnificationXref
id: 3669544
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669544

Cytosolic Fe-S cluster assembly factor CFD1
type: Protein
entity reference: P40558
data source: Provenance1
name: CFD1_YEAST
xref: UnificationXref6632
xref: UnificationXref6633
feature: FragmentFeature1071
cellular location: GO:0005829
comment: Reactome DB_ID: 2564764
display name: CFD1

http://identifiers.org/pubmed/18173545
type: PublicationXref
id: 18173545
author: Calamita, G
author: Svelto, M
author: Portincasa, P
author: Palasciano, G
db: Pubmed
title: Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease
source: Eur J Clin Invest 38:1-10
year: 2008

UnificationXref8008
type: UnificationXref
id: REACT_139456
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139456.5

UnificationXref8009
type: UnificationXref
id: P17119
db: UniProt

UnificationXref8006
type: UnificationXref
id: 3671876
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671876

UnificationXref8007
type: UnificationXref
id: 3671877
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671877

UnificationXref8004
type: UnificationXref
id: P53086
db: UniProt

UnificationXref8005
type: UnificationXref
id: 3671875
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671875

UnificationXref8002
type: UnificationXref
id: 3671889
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671889

UnificationXref8003
type: UnificationXref
id: REACT_146886
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146886.5

UnificationXref8012
type: UnificationXref
id: 3671895
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671895

UnificationXref8011
type: UnificationXref
id: 3671894
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671894

UnificationXref8010
type: UnificationXref
id: 3671893
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671893

The retinoid cycle in cones (daylight vision)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction110
evidence: Evidence229
xref: UnificationXref2248
xref: RelationshipXref131
xref: UnificationXref2249
pathway order: PathwayStep230
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8001
type: UnificationXref
id: 3671888
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671888

UnificationXref8000
type: UnificationXref
id: 3671887
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671887

http://identifiers.org/pubmed/8723348
type: PublicationXref
id: 8723348
author: Jefferson, AB
author: Pot, DA
author: Deuter-Reinhard, M
author: Masiarz, FR
author: Cousens, LS
author: Williams, LT
author: Chin, SM
author: Norris, FA
author: Kavanaugh, WM
author: Majerus, PW
db: Pubmed
title: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
source: Curr Biol 6:438-45
year: 1996

http://identifiers.org/pubmed/1894595
type: PublicationXref
id: 1894595
author: Burbaum, JJ
author: Schimmel, P
db: Pubmed
title: Structural relationships and the classification of aminoacyl-tRNA synthetases
source: J Biol Chem 266:16965-8
year: 1991

http://identifiers.org/pubmed/21173190
type: PublicationXref
id: 21173190
author: Agarwal, AK
author: Prasad, SS
author: Garg, A
db: Pubmed
title: Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria
source: J Lipid Res 52:451-62
year: 2011

http://identifiers.org/pubmed/8167409
type: PublicationXref
id: 8167409
author: McMahon, Jill A
author: Smolich, Beverly D
author: McMahon, Andrew P
author: Papkoff, Jackie
db: Pubmed
title: Wnt family proteins are secreted and associated with the cell surface
source: Mol. Biol. Cell 4:1267-75
year: 1993

http://identifiers.org/pubmed/16483939
type: PublicationXref
id: 16483939
author: Pacek, M
author: Kubota, Y
author: Takisawa, H
author: Tutter, AV
author: Walter, JC
db: Pubmed
title: Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication
source: Mol Cell 21:581-7
year: 2006

http://identifiers.org/pubmed/8411712
type: PublicationXref
id: 8411712
author: Kamijo, K
author: Osumi, T
author: Hashimoto, T
db: Pubmed
title: PMP70, the 70-kDa peroxisomal membrane protein: a member of the ATP-binding cassette transporters
source: Nippon Rinsho 51:2343-52
year: 1993

http://identifiers.org/pubmed/9110970
type: PublicationXref
id: 9110970
author: Lingner, J
author: Shevchenko, A
author: Hughes, TR
author: Lundblad, V
author: Mann, M
author: Cech, TR
db: Pubmed
title: Reverse transcriptase motifs in the catalytic subunit of telomerase
source: Science 276:561-7
year: 1997

http://identifiers.org/pubmed/3049610
type: PublicationXref
id: 3049610
author: Smith, BL
author: Agre, P
author: Denker, BM
author: Kuhajda, FP
db: Pubmed
title: Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules
source: J Biol Chem 263:15634-42
year: 1988

http://identifiers.org/pubmed/16339074
type: PublicationXref
id: 16339074
author: Supakorndej, T
author: Tomlinson, RL
author: Terns, RM
author: Ziegler, TD
author: Terns, MP
db: Pubmed
title: Cell cycle-regulated trafficking of human telomerase to telomeres
source: Mol Biol Cell 17:955-65
year: 2006

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
type: Pathway
data source: Provenance1
pathway component: REACT 86624.9
evidence: Evidence626
xref: RelationshipXref553
xref: UnificationXref4991
xref: UnificationXref4992
pathway order: PathwayStep627
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3895
type: UnificationXref
id: REACT_10685
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10685.1

UnificationXref3894
type: UnificationXref
id: 193459
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193459

UnificationXref3893
type: UnificationXref
id: CHEBI:27393
db: ChEBI

UnificationXref3892
type: UnificationXref
id: REACT_102925
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102925.9

UnificationXref3891
type: UnificationXref
id: 3669335
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669335

UnificationXref3890
type: UnificationXref
id: REACT_10198
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10198.1

UnificationXref3899
type: UnificationXref
id: 3669350
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669350

UnificationXref3898
type: UnificationXref
id: REACT_10857
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10857.1

UnificationXref3897
type: UnificationXref
id: 193388
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193388

UnificationXref3896
type: UnificationXref
id: CHEBI:27403
db: ChEBI

http://identifiers.org/pubmed/17008356
type: PublicationXref
id: 17008356
author: Monroy, N
author: Kretz, C
author: Mandel, JL
author: Payrastre, B
author: Dondaine, N
author: Tronchère, H
author: Zanoteli, E
author: Rohde, HM
author: Tosch, V
author: Laporte, J
db: Pubmed
title: A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy
source: Hum Mol Genet 15:3098-106
year: 2006

http://identifiers.org/pubmed/8325892
type: PublicationXref
id: 8325892
author: Froguel, P
author: Velho, G
author: Stoffel, M
author: Vionnet, N
author: Cohen, D
author: Takeda, J
author: St. Charles, R
author: Bell, GI
author: Vaxillaire, M
author: Pilkis, SJ
author: Weber, IT
author: Gidh-Jain, M
author: Shimada, F
author: Nishi, S
author: Harrison, RW
author: Makino, H
author: Xu, LZ
db: Pubmed
title: Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants.
source: J Biol Chem 268:15200-4
year: 1993

UnificationXref3882
type: UnificationXref
id: REACT_112696
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112696.8

UnificationXref3881
type: UnificationXref
id: 3669327
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669327

UnificationXref3884
type: UnificationXref
id: REACT_126415
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126415.5

UnificationXref3883
type: UnificationXref
id: 3669345
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669345

UnificationXref3880
type: UnificationXref
id: 3668712
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668712

http://identifiers.org/pubmed/22649417
type: PublicationXref
id: 22649417
author: Siddle, Kenneth
db: Pubmed
title: Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances
source: Front Endocrinol (Lausanne) 3:34
year: 2012

UnificationXref3889
type: UnificationXref
id: 193422
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193422

UnificationXref3886
type: UnificationXref
id: 192342
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192342

UnificationXref3885
type: UnificationXref
id: CHEBI:27505
db: ChEBI

5-PP-InsP5
type: SmallMoleculeReference
name: 5-PP-InsP5 [ChEBI:2119]
name: 5-Diphosphoinositol pentakisphosphate
xref: UnificationXref3110

UnificationXref3888
type: UnificationXref
id: CHEBI:52050
db: ChEBI

UnificationXref3887
type: UnificationXref
id: REACT_10191
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10191.2

Cysteine formation from homocysteine
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction536
pathway component: BiochemicalReaction535
evidence: Evidence805
xref: UnificationXref6244
xref: UnificationXref6245
xref: RelationshipXref802
pathway order: PathwayStep805
pathway order: PathwayStep806
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite1141
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1140
type: SequenceSite
position status: EQUAL
sequence position: 247

RelationshipXref1061
type: RelationshipXref
id: 3669503
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669503

RelationshipXref1060
type: RelationshipXref
id: GO:0048015
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1063
type: RelationshipXref
id: 3669532
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669532

RelationshipXref1062
type: RelationshipXref
id: GO:0005096
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref1065
type: RelationshipXref
id: GO:0004115
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref1064
type: RelationshipXref
id: GO:0051056
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1067
type: RelationshipXref
id: GO:0045007
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1066
type: RelationshipXref
id: 3670666
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670666

RelationshipXref1069
type: RelationshipXref
id: 3668462
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668462

RelationshipXref1068
type: RelationshipXref
id: GO:0008534
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite1139
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1135
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1136
type: SequenceSite
position status: EQUAL
sequence position: 118

SequenceSite1137
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1138
type: SequenceSite
position status: EQUAL
sequence position: 119

SequenceSite1131
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1132
type: SequenceSite
position status: EQUAL
sequence position: 617

SequenceSite1133
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1134
type: SequenceSite
position status: EQUAL
sequence position: 118

SequenceSite1130
type: SequenceSite
position status: EQUAL
sequence position: 226

RelationshipXref1072
type: RelationshipXref
id: 3668448
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668448

RelationshipXref1071
type: RelationshipXref
id: GO:0000703
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref1070
type: RelationshipXref
id: GO:0045008
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1076
type: RelationshipXref
id: 3668475
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668475

http://identifiers.org/pubmed/1939222
type: PublicationXref
id: 1939222
author: Cox, TM
author: Gardner, LC
author: Smith, SJ
db: Pubmed
title: Biosynthesis of delta-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in man
source: J Biol Chem 266:22010-8
year: 1991

RelationshipXref1075
type: RelationshipXref
id: 3668473
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668473

http://identifiers.org/pubmed/12655297
type: PublicationXref
id: 12655297
author: Janicke, RU
author: Schulze-Osthoff, K
author: Fischer, U
db: Pubmed
title: Many cuts to ruin: a comprehensive update of caspase substrates
source: Cell Death Differ 10:76-100
year: 2003

RelationshipXref1074
type: RelationshipXref
id: GO:0006284
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1073
type: RelationshipXref
id: GO:0006285
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1079
type: RelationshipXref
id: GO:0003908
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref1078
type: RelationshipXref
id: 3668486
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668486

RelationshipXref1077
type: RelationshipXref
id: 3668484
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668484

SequenceSite1128
type: SequenceSite
position status: EQUAL
sequence position: 226

SequenceSite1129
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1126
type: SequenceSite
position status: EQUAL
sequence position: 205

SequenceSite1127
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1124
type: SequenceSite
position status: EQUAL
sequence position: 155

SequenceSite1125
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1122
type: SequenceSite
position status: EQUAL
sequence position: 856

SequenceSite1123
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1120
type: SequenceSite
position status: EQUAL
sequence position: 856

SequenceSite1121
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:P00546
type: ProteinReference
xref: UnificationXref118
organism: BioSource1

RelationshipXref1081
type: RelationshipXref
id: GO:0006307
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1080
type: RelationshipXref
id: 3667749
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667749

RelationshipXref1083
type: RelationshipXref
id: GO:0046777
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1082
type: RelationshipXref
id: GO:0006281
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite1161
type: SequenceSite
position status: EQUAL
sequence position: 710

SequenceSite1160
type: SequenceSite
position status: EQUAL
sequence position: 566

SequenceSite1163
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1162
type: SequenceSite
position status: EQUAL
sequence position: 729

RelationshipXref1089
type: RelationshipXref
id: GO:0000717
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1088
type: RelationshipXref
id: 3667784
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667784

http://identifiers.org/pubmed/18240029
type: PublicationXref
id: 18240029
author: Luttrell, LM
db: Pubmed
title: Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors
source: Mol Biotechnol 39:239-64
year: 2008

RelationshipXref1085
type: RelationshipXref
id: GO:0000724
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1084
type: RelationshipXref
id: GO:0000730
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1087
type: RelationshipXref
id: GO:0000715
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1086
type: RelationshipXref
id: GO:0006302
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/8325954
type: PublicationXref
id: 8325954
author: Ciaraldi, TP
author: Hueckstaedt, TP
author: Wilkinson, W
author: Olefsky, JM
author: Garvey, WT
author: Pilch, PF
db: Pubmed
title: Insulin-responsive human adipocytes express two glucose transporter isoforms and target them to different vesicles
source: J Clin Endocrinol Metab 77:286-9
year: 1993

SequenceSite1153
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1154
type: SequenceSite
position status: EQUAL
sequence position: 737

SequenceSite1155
type: SequenceSite
position status: EQUAL
sequence position: 507

SequenceSite1156
type: SequenceSite
position status: EQUAL
sequence position: 645

SequenceSite1157
type: SequenceSite
position status: EQUAL
sequence position: 664

SequenceSite1158
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1159
type: SequenceSite
position status: EQUAL
sequence position: 676

http://identifiers.org/pubmed/14739288
type: PublicationXref
id: 14739288
author: Dowd, LO
author: Augustin, R
author: Phay, JE
author: Moley, JF
author: Moley, KH
author: Carayannopoulos, MO
db: Pubmed
title: Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking
source: J Biol Chem 279:16229-36
year: 2004

http://identifiers.org/pubmed/16321791
type: PublicationXref
id: 16321791
author: Joseph, JW
author: MacDonald, PE
author: Rorsman, P
db: Pubmed
title: Glucose-sensing mechanisms in pancreatic beta-cells
source: Philos Trans R Soc Lond B Biol Sci 360:2211-25
year: 2005

RelationshipXref1094
type: RelationshipXref
id: GO:0000718
db: GENE ONTOLOGY
relationship type: MI:0359

DNA-directed RNA polymerase III 36 kDa polypeptide
type: Protein
entity reference: P32910
data source: Provenance1
name: RPC6_YEAST
xref: UnificationXref7041
xref: UnificationXref7042
cellular location: GO:0005654
comment: Reactome DB_ID: 111825
display name: C34

RelationshipXref1093
type: RelationshipXref
id: GO:0006295
db: GENE ONTOLOGY
relationship type: MI:0359

RNA polymerase III subunit 2
type: Protein
entity reference: P22276
data source: Provenance1
name: DNA-directed RNA polymerase III 130 kDa polypeptide
name: RPC2_YEAST
xref: UnificationXref7045
xref: UnificationXref7044
cellular location: GO:0005654
comment: Reactome DB_ID: 111821
display name: C128

RelationshipXref1092
type: RelationshipXref
id: 3667797
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667797

RPC8_YEAST
type: Protein
entity reference: P17890
data source: Provenance1
name: DNA-directed RNA polymerase III 31 kDa polypeptide
xref: UnificationXref7037
xref: UnificationXref7036
cellular location: GO:0005654
comment: Reactome DB_ID: 111826
display name: C31

RelationshipXref1091
type: RelationshipXref
id: GO:0004519
db: GENE ONTOLOGY
relationship type: MI:0355

RPB8_YEAST
type: Protein
entity reference: YOR224C
data source: Provenance1
name: DNA-directed RNA polymerases I, II, and III 14.5 kDa polypeptide
xref: UnificationXref7038
xref: UnificationXref7039
cellular location: GO:0005654
comment: Reactome DB_ID: 111835
display name: ABC14.4

RelationshipXref1090
type: RelationshipXref
id: GO:0006293
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite1152
type: SequenceSite
position status: EQUAL
sequence position: 676

RPC1_YEAST
type: Protein
entity reference: P04051
data source: Provenance1
name: DNA-directed RNA polymerase III largest subunit
xref: UnificationXref7032
xref: UnificationXref7031
cellular location: GO:0005654
comment: Reactome DB_ID: 111820
display name: C160

SequenceSite1151
type: SequenceSite
position status: EQUAL
sequence position: 1

RPBX_YEAST
type: Protein
entity reference: UniProt:P22139 RPB10
data source: Provenance1
name: DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide
name: ABC10-beta
xref: UnificationXref7033
xref: UnificationXref7034
cellular location: GO:0005654
comment: Reactome DB_ID: 111837
display name: ABC8

SequenceSite1150
type: SequenceSite
position status: EQUAL
sequence position: 511

RelationshipXref1099
type: RelationshipXref
id: GO:0006289
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1098
type: RelationshipXref
id: GO:0006283
db: GENE ONTOLOGY
relationship type: MI:0359

RPC9_YEAST
type: Protein
entity reference: UniProt:P28000 RPC19
data source: Provenance1
name: DNA-directed RNA polymerases I and III 16 kDa polypeptide
xref: UnificationXref7052
xref: UnificationXref7053
cellular location: GO:0005654
comment: Reactome DB_ID: 111832
display name: AC19

RelationshipXref1097
type: RelationshipXref
id: 3668410
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668410

DNA-directed RNA polymerases I, II, and III 7.7 kDa polypeptide
type: Protein
entity reference: P40422
data source: Provenance1
name: ABC10-alpha
xref: UnificationXref7055
xref: UnificationXref7056
cellular location: GO:0005654
comment: Reactome DB_ID: 111836
display name: RPCX_YEAST

RelationshipXref1096
type: RelationshipXref
id: GO:0000716
db: GENE ONTOLOGY
relationship type: MI:0359

DNA-directed RNA polymerases III 12.5 kDa polypeptide
type: Protein
entity reference: Q04307
data source: Provenance1
xref: UnificationXref7048
xref: UnificationXref7047
cellular location: GO:0005654
comment: Reactome DB_ID: 111831
display name: RPCZ_YEAST

RelationshipXref1095
type: RelationshipXref
id: GO:0006297
db: GENE ONTOLOGY
relationship type: MI:0359

DNA-directed RNA polymerase III 47 kDa polypeptide
type: Protein
entity reference: P25441
data source: Provenance1
name: RPC4_YEAST
name: RNA polymerase C subunit 4
xref: UnificationXref7050
xref: UnificationXref7051
cellular location: GO:0005654
comment: Reactome DB_ID: 111822
display name: C53

http://identifiers.org/pubmed/14638855
type: PublicationXref
id: 14638855
author: Voos, W
author: Müller, H
author: Pfanner, N
author: Truscott, KN
author: Guiard, B
author: Meyer, HE
author: Meisinger, C
author: Sickmann, A
author: Lind, M
author: Rehling, P
author: Frazier, AE
author: Geissler, A
author: Dudek, J
author: Li, Y
db: Pubmed
title: A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria
source: J Cell Biol 163:707-13
year: 2003

SequenceSite1144
type: SequenceSite
position status: EQUAL
sequence position: 382

SequenceSite1145
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1142
type: SequenceSite
position status: EQUAL
sequence position: 483

SequenceSite1143
type: SequenceSite
position status: EQUAL
sequence position: 2

UniProt:P00549
type: ProteinReference
xref: UnificationXref2693
organism: BioSource1

SequenceSite1148
type: SequenceSite
position status: EQUAL
sequence position: 513

SequenceSite1149
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1146
type: SequenceSite
position status: EQUAL
sequence position: 427

SequenceSite1147
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref1020
type: RelationshipXref
id: GO:0005464
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref1021
type: RelationshipXref
id: 3671411
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671411

RelationshipXref1022
type: RelationshipXref
id: GO:0005462
db: GENE ONTOLOGY
relationship type: MI:0355

UniProt:P00560
type: ProteinReference
xref: UnificationXref2668
organism: BioSource1

RelationshipXref1023
type: RelationshipXref
id: 3671409
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671409

RelationshipXref1024
type: RelationshipXref
id: GO:0015245
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref1025
type: RelationshipXref
id: 3671448
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671448

http://identifiers.org/pubmed/8246982
type: PublicationXref
id: 8246982
author: Wagner, BJ
author: Brewer, G
author: DeHaven, K
author: Schaefer, AW
author: Long, L
author: Crater, D
author: Ehrenman, K
author: Zhang, W
author: DeMaria, CT
db: Pubmed
title: Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1
source: Mol Cell Biol 13:7652-65
year: 1993

RelationshipXref1027
type: RelationshipXref
id: GO:0015250
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref1026
type: RelationshipXref
id: GO:0015909
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1029
type: RelationshipXref
id: GO:0015254
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref1028
type: RelationshipXref
id: 3671287
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671287

http://identifiers.org/pubmed/15215243
type: PublicationXref
id: 15215243
author: Graf, SA
author: Shirihai, OS
author: Corson, ED
author: Haigh, SE
db: Pubmed
title: Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me)
source: J Biol Chem 279:42954-63
year: 2004

RelationshipXref1031
type: RelationshipXref
id: GO:0015265
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref1032
type: RelationshipXref
id: 3671294
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671294

RelationshipXref1030
type: RelationshipXref
id: 3671289
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671289

RelationshipXref1035
type: RelationshipXref
id: 3670872
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670872

RelationshipXref1036
type: RelationshipXref
id: 3670868
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670868

UniProt:P00572
type: ProteinReference
xref: UnificationXref5404
organism: BioSource1

RelationshipXref1033
type: RelationshipXref
id: GO:0006833
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1034
type: RelationshipXref
id: 3671010
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671010

UniProt:P07807
type: ProteinReference
xref: UnificationXref981
organism: BioSource1

UniProt:P07806
type: ProteinReference
xref: UnificationXref7350
organism: BioSource1

RelationshipXref1039
type: RelationshipXref
id: GO:0033572
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1038
type: RelationshipXref
id: 3667972
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667972

RelationshipXref1037
type: RelationshipXref
id: GO:0015793
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/6323448
type: PublicationXref
id: 6323448
author: Cline, A
author: Moulton, AD
author: Nienhuis, AW
author: Chen, MJ
author: Humphries, RK
author: Shimada, T
author: Maizel, J
db: Pubmed
title: The functional human dihydrofolate reductase gene
source: J Biol Chem 259:3933-43
year: 1984

RelationshipXref1044
type: RelationshipXref
id: 3671746
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671746

RelationshipXref1045
type: RelationshipXref
id: GO:0034220
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1046
type: RelationshipXref
id: 3668841
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668841

RelationshipXref1047
type: RelationshipXref
id: 3668860
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668860

RelationshipXref1040
type: RelationshipXref
id: GO:0006879
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1041
type: RelationshipXref
id: GO:0005388
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref1042
type: RelationshipXref
id: 3671727
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671727

RelationshipXref1043
type: RelationshipXref
id: GO:0004012
db: GENE ONTOLOGY
relationship type: MI:0355

TRAF6 Mediated Induction of proinflammatory cytokines
type: Pathway
data source: Provenance1
pathway component: REACT 85645.9
evidence: Evidence1040
xref: UnificationXref8056
xref: UnificationXref8055
xref: RelationshipXref987
pathway order: PathwayStep1050
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite1110
type: SequenceSite
position status: EQUAL
sequence position: 830

SequenceSite1112
type: SequenceSite
position status: EQUAL
sequence position: 837

SequenceSite1111
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1114
type: SequenceSite
position status: EQUAL
sequence position: 837

SequenceSite1113
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1116
type: SequenceSite
position status: EQUAL
sequence position: 840

SequenceSite1115
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1118
type: SequenceSite
position status: EQUAL
sequence position: 840

SequenceSite1117
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1119
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref1049
type: RelationshipXref
id: GO:0043065
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1048
type: RelationshipXref
id: GO:0008286
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1057
type: RelationshipXref
id: GO:0007264
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1058
type: RelationshipXref
id: GO:0000186
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1055
type: RelationshipXref
id: GO:0048011
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1056
type: RelationshipXref
id: GO:0007265
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1053
type: RelationshipXref
id: GO:0050771
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1054
type: RelationshipXref
id: GO:0050770
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref1051
type: RelationshipXref
id: GO:0005089
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref1052
type: RelationshipXref
id: 3669392
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669392

RelationshipXref1050
type: RelationshipXref
id: GO:0097190
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite1101
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1100
type: SequenceSite
position status: EQUAL
sequence position: 200

SequenceSite1105
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1104
type: SequenceSite
position status: EQUAL
sequence position: 351

SequenceSite1103
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1102
type: SequenceSite
position status: EQUAL
sequence position: 204

SequenceSite1109
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1108
type: SequenceSite
position status: EQUAL
sequence position: 830

SequenceSite1107
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1106
type: SequenceSite
position status: EQUAL
sequence position: 350

RelationshipXref1059
type: RelationshipXref
id: GO:0007202
db: GENE ONTOLOGY
relationship type: MI:0359

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q12469
data source: Provenance1
name: PAK-2p34
name: PAK2(213-524)
xref: UnificationXref6918
feature: FragmentFeature1103
cellular location: GO:0005829
comment: Reactome DB_ID: 3670081
display name: Q12469

http://identifiers.org/pubmed/17560368
type: PublicationXref
id: 17560368
author: Peters, L
author: Meister, G
db: Pubmed
title: Argonaute proteins: mediators of RNA silencing
source: Mol Cell 26:611-23
year: 2007

http://identifiers.org/pubmed/1944596
type: PublicationXref
id: 1944596
author: Russell, DW
author: Andersson, S
author: Berman, DM
author: Jenkins, EP
db: Pubmed
title: Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism
source: Nature 354:159-61
year: 1991

Leukotriene D4 [ChEBI:6423]
type: SmallMoleculeReference
name: LTD4
name: Leukotriene D4
xref: UnificationXref4545

Homologues of CYCS
type: Protein
data source: Provenance1
member physical entity: P00045
member physical entity: P00044
xref: UnificationXref6903
cellular location: GO:0005758
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3668628

Homologues of CYCS
type: Protein
data source: Provenance1
member physical entity: P00045
member physical entity: P00044
xref: UnificationXref6906
cellular location: GO:0005829
comment: Reactome DB_ID: 3668625
comment: Converted from EntitySet in Reactome

dolichyl D-mannosyl phosphate [ChEBI:15809]
type: SmallMoleculeReference
name: Dolichyl phosphate D-mannose
name: dolichyl D-mannosyl phosphate
xref: UnificationXref9462

P00045
type: Protein
entity reference: UniProt:P00045
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cytochrome c
xref: UnificationXref6904
feature: FragmentFeature1099
cellular location: GO:0005829
comment: Reactome DB_ID: 3668620
display name: CYCS

P00045
type: Protein
entity reference: UniProt:P00045
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cytochrome c
xref: UnificationXref6900
feature: FragmentFeature1097
cellular location: GO:0005758
comment: Reactome DB_ID: 3668626
display name: CYCS

P00044
type: Protein
entity reference: UniProt:P00044
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cytochrome c
xref: UnificationXref6902
feature: FragmentFeature1098
cellular location: GO:0005758
comment: Reactome DB_ID: 3668627
display name: CYCS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q03497
data source: Provenance1
name: PAK-2p34
name: PAK2(213-524)
xref: UnificationXref6914
feature: FragmentFeature1101
cellular location: GO:0005829
comment: Reactome DB_ID: 3670079
display name: Q03497

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P48562
data source: Provenance1
name: PAK-2p34
name: PAK2(213-524)
xref: UnificationXref6916
feature: FragmentFeature1102
cellular location: GO:0005829
comment: Reactome DB_ID: 3670080
display name: P48562

P00044
type: Protein
entity reference: UniProt:P00044
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cytochrome c
xref: UnificationXref6905
feature: FragmentFeature1100
cellular location: GO:0005829
comment: Reactome DB_ID: 3668624
display name: CYCS

O-(1-beta-Acyl-2-acyl-sn-glycero-3-phospho)ethanolamine
type: SmallMoleculeReference
name: Cephalin
name: phosphatidylethanolamine [ChEBI:16038]
name: 1-Acyl-2-acyl-sn-glycero-3-phosphoethanolamine
name: phosphatidylethanolamines
name: (3-Phosphatidyl)-ethanolamine
name: phosphatidylethanolamine
name: 1,2-diacyl-sn-glycero-3-phosphoethanolamine
name: (3-Phosphatidyl)ethanolamine
xref: UnificationXref9447

Homologues of PAK2(213-524)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref6919
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670082

http://identifiers.org/pubmed/6311078
type: PublicationXref
id: 6311078
author: Hammarström, Sven
db: Pubmed
title: Leukotrienes
source: Annu Rev Biochem 52:355-77
year: 1983

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q04991
data source: Provenance1
name: Q04991
name: Large neutral amino acids transporter small subunit 4
name: L-type amino L-acid transporter 4
name: SLC43A2
xref: UnificationXref6893
feature: FragmentFeature1096
cellular location: GO:0005886
comment: Reactome DB_ID: 3670244
display name: LAT4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q04991
data source: Provenance1
name: L-type amino acid transporter 3
name: Q04991
name: SLC43A1
name: Large neutral amino acids transporter small subunit 3
xref: UnificationXref6890
feature: FragmentFeature1095
cellular location: GO:0005886
comment: Reactome DB_ID: 3670241
display name: LAT3

http://identifiers.org/pubmed/8892014
type: PublicationXref
id: 8892014
author: Treacy, E
author: Thompson, GN
author: Pitt, JJ
author: Cotton, RG
author: Seller, K
author: Ramus, S
db: Pubmed
title: In vivo disposal of phenylalanine in phenylketonuria: a study of two siblings
source: J Inherit Metab Dis 19:595-602
year: 1996

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32901
data source: Provenance1
name: Solute carrier family 15 member 4
name: Peptide/histidine transporter 1
name: SLC15A4
name: S15A4_HUMAN
name: P32901
xref: UnificationXref6847
feature: FragmentFeature1088
cellular location: GO:0005765
comment: Reactome DB_ID: 3670713
display name: PHT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32901
data source: Provenance1
name: Peptide/histidine transporter 2
name: S15A3_HUMAN
name: Solute carrier family 15 member 3
name: SLC15A3
name: P32901
xref: UnificationXref6848
feature: FragmentFeature1089
cellular location: GO:0005765
comment: Reactome DB_ID: 3670714
display name: PHT2

SLC32A1
type: Protein
entity reference: P47082
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: VIAAT_HUMAN
name: Vesicular inhibitory amino acid transporter
xref: UnificationXref6871
feature: FragmentFeature1090
cellular location: GO:0030672
comment: Reactome DB_ID: 3670761
display name: P47082

Homologues of SLC16A10
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref6882
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670263

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P36032
data source: Provenance1
name: SLC16A10
name: Large neutral amino acids transporter small subunit 2
name: P36032
xref: UnificationXref6878
feature: FragmentFeature1091
cellular location: GO:0005886
comment: Reactome DB_ID: 3670250
display name: LAT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q08777
data source: Provenance1
name: SLC16A10
name: Q08777
name: Large neutral amino acids transporter small subunit 2
xref: UnificationXref6879
feature: FragmentFeature1092
cellular location: GO:0005886
comment: Reactome DB_ID: 3670254
display name: LAT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P53918
data source: Provenance1
name: SLC16A10
name: P53918
name: Large neutral amino acids transporter small subunit 2
xref: UnificationXref6880
feature: FragmentFeature1093
cellular location: GO:0005886
comment: Reactome DB_ID: 3670258
display name: LAT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q08268
data source: Provenance1
name: SLC16A10
name: Q08268
name: Large neutral amino acids transporter small subunit 2
xref: UnificationXref6881
feature: FragmentFeature1094
cellular location: GO:0005886
comment: Reactome DB_ID: 3670262
display name: LAT2

RelationshipXref1008
type: RelationshipXref
id: GO:0005385
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref1009
type: RelationshipXref
id: 3670935
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670935

RelationshipXref1006
type: RelationshipXref
id: 3670793
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670793

RelationshipXref1007
type: RelationshipXref
id: 3670801
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670801

PHT cotransporters
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref6849
cellular location: GO:0005765
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670715

RelationshipXref1004
type: RelationshipXref
id: 3670796
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670796

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32901
data source: Provenance1
name: Peptide transporter 2
name: S15A2_HUMAN
name: SLC15A2
name: Solute carrier family 15 member 2
name: P32901
xref: UnificationXref6791
feature: FragmentFeature1087
cellular location: GO:0005886
comment: Reactome DB_ID: 3670709
display name: PEPT2

RelationshipXref1005
type: RelationshipXref
id: GO:0051119
db: GENE ONTOLOGY
relationship type: MI:0355

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32901
data source: Provenance1
name: Peptide transporter 1
name: SLC15A1
name: S15A1_HUMAN
name: Solute carrier family 15 member 1
name: P32901
xref: UnificationXref6790
feature: FragmentFeature1086
cellular location: GO:0005886
comment: Reactome DB_ID: 3670708
display name: PEPT1

http://identifiers.org/pubmed/11572773
type: PublicationXref
id: 11572773
author: Blackburn, EH
db: Pubmed
title: Switching and signaling at the telomere
source: Cell 106:661-73
year: 2001

http://identifiers.org/pubmed/9207117
type: PublicationXref
id: 9207117
author: Zhou, B
author: Gitschier, J
db: Pubmed
title: hCTR1: a human gene for copper uptake identified by complementation in yeast
source: Proc Natl Acad Sci U S A 94:7481-6
year: 1997

RelationshipXref1003
type: RelationshipXref
id: GO:0055056
db: GENE ONTOLOGY
relationship type: MI:0355

Protein SAE2
type: Protein
entity reference: P46946
data source: Provenance1
name: SAE2_YEAST
xref: UnificationXref6753
xref: UnificationXref6754
feature: FragmentFeature1085
cellular location: GO:0005654
comment: Reactome DB_ID: 981770
display name: SAE2

RelationshipXref1002
type: RelationshipXref
id: GO:0006811
db: GENE ONTOLOGY
relationship type: MI:0359

PEPT cotransporters
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref6792
cellular location: GO:0005886
comment: Reactome DB_ID: 3670710
comment: Converted from EntitySet in Reactome

RelationshipXref1001
type: RelationshipXref
id: 3670694
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670694

MRE11_YEAST
type: Protein
entity reference: P32829
data source: Provenance1
name: Double-strand break repair protein MRE11
xref: UnificationXref6746
xref: UnificationXref6745
feature: FragmentFeature1083
cellular location: GO:0005654
comment: Reactome DB_ID: 981772
display name: MRE11

RelationshipXref1000
type: RelationshipXref
id: 3670700
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670700

RAD50_YEAST
type: Protein
entity reference: P12753
data source: Provenance1
name: DNA repair protein RAD50
xref: UnificationXref6749
xref: UnificationXref6748
feature: FragmentFeature1084
cellular location: GO:0005654
comment: Reactome DB_ID: 981774
display name: RAD50

SPO11_YEAST
type: Protein
entity reference: P23179
data source: Provenance1
name: Meiosis-specific protein SPO11
xref: UnificationXref6730
xref: UnificationXref6729
feature: FragmentFeature1081
cellular location: GO:0005654
comment: Reactome DB_ID: 981775
display name: SPO11

XRS2_YEAST
type: Protein
entity reference: P33301
data source: Provenance1
name: DNA repair protein XRS2
xref: UnificationXref6743
xref: UnificationXref6742
feature: FragmentFeature1082
cellular location: GO:0005654
comment: Reactome DB_ID: 981771
display name: XRS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P23179
data source: Provenance1
name: Meiotic recombination protein SPO11
name: SPO11_HUMAN
name: P23179
xref: UnificationXref6722
feature: FragmentFeature1080
cellular location: GO:0005654
comment: Reactome DB_ID: 3671514
display name: SPO11

RelationshipXref1019
type: RelationshipXref
id: 3671402
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671402

RelationshipXref1015
type: RelationshipXref
id: 3668316
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668316

MMS19
type: Protein
entity reference: P40469
data source: Provenance1
name: DNA repair/transcription protein MET18/MMS19
name: MET18_YEAST
xref: UnificationXref6664
xref: UnificationXref6663
feature: FragmentFeature1079
cellular location: GO:0005829
comment: Reactome DB_ID: 2564782
display name: MET18

RelationshipXref1016
type: RelationshipXref
id: 3668312
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668312

CIAO1_YEAST
type: Protein
entity reference: CIA1
data source: Provenance1
name: Cytosolic iron-sulfur protein assembly protein 1
xref: UnificationXref6660
xref: UnificationXref6661
feature: FragmentFeature1078
cellular location: GO:0005829
comment: Reactome DB_ID: 2564768
display name: CIA1

RelationshipXref1017
type: RelationshipXref
id: 3671391
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671391

Eukaryotic peptide chain release factor subunit 1
type: Protein
entity reference: P12385
data source: Provenance1
xref: UnificationXref6697
xref: UnificationXref6696
cellular location: GO:0005829
comment: Reactome DB_ID: 141665
display name: Erf-1

RelationshipXref1018
type: RelationshipXref
id: GO:0008521
db: GENE ONTOLOGY
relationship type: MI:0355

eRF3
type: Protein
entity reference: P05453
data source: Provenance1
xref: UnificationXref6683
xref: UnificationXref6682
feature: EntityFeature1
cellular location: GO:0005829
comment: Reactome DB_ID: 141686

RelationshipXref1012
type: RelationshipXref
id: GO:0005375
db: GENE ONTOLOGY
relationship type: MI:0355

RAD3_YEAST
type: Protein
entity reference: P06839
data source: Provenance1
name: DNA repair helicase RAD3 ecNumber3.6.4.12/ecNumber
name: apo-RAD3
xref: UnificationXref6645
xref: UnificationXref6644
feature: FragmentFeature1074
cellular location: GO:0005829
comment: Reactome DB_ID: 2564780
display name: RAD3

RelationshipXref1011
type: RelationshipXref
id: 3670944
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670944

DNA replication ATP-dependent helicase DNA2 ecNumber3.6.4.12/ecNumber
type: Protein
entity reference: DNA2
data source: Provenance1
name: DNA2_YEAST
name: apo-DNA2
xref: UnificationXref6648
xref: UnificationXref6647
feature: FragmentFeature1075
cellular location: GO:0005829
comment: Reactome DB_ID: 2564783
display name: DNA2

RelationshipXref1014
type: RelationshipXref
id: GO:0005337
db: GENE ONTOLOGY
relationship type: MI:0355

MIP18 family protein YHR122W
type: Protein
entity reference: UniProt:P38829 YHR122W
data source: Provenance1
name: YHS2_YEAST
xref: UnificationXref6653
xref: UnificationXref6652
feature: FragmentFeature1076
cellular location: GO:0005829
comment: Reactome DB_ID: 2564773
display name: YHR122W

RelationshipXref1013
type: RelationshipXref
id: 3670951
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670951

Cytosolic Fe-S cluster assembly factor NAR1
type: Protein
entity reference: P23503
data source: Provenance1
name: NAR1_YEAST
xref: UnificationXref6655
xref: UnificationXref6656
feature: FragmentFeature1077
cellular location: GO:0005829
comment: Reactome DB_ID: 2564785
display name: NAR1

http://identifiers.org/pubmed/20110263
type: PublicationXref
id: 20110263
author: Kersten, S
author: de Groot, PJ
author: de Vries, SC
author: Muller, M
author: Degenhardt, T
author: Carlberg, C
author: Vaisanen, S
author: Heinaniemi, M
author: van der Meer, DL
db: Pubmed
title: Profiling of promoter occupancy by PPAR{alpha} in human hepatoma cells via ChIP-chip analysis
source: Nucleic Acids Res
year: 2010

http://identifiers.org/pubmed/15276183
type: PublicationXref
id: 15276183
author: Gangloff, M
author: Gay, NJ
db: Pubmed
title: MD-2: the Toll 'gatekeeper' in endotoxin signalling
source: Trends Biochem Sci 29:294-300
year: 2004

RelationshipXref1010
type: RelationshipXref
id: 3670941
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670941

Apoprotein Lacking 4Fe-4S Cluster
type: Protein
data source: Provenance1
member physical entity: DNA replication ATP-dependent helicase DNA2 ecNumber3.6.4.12/ecNumber
member physical entity: DPOD_YEAST
member physical entity: RAD3_YEAST
xref: UnificationXref6649
xref: UnificationXref6650
cellular location: GO:0005829
comment: Reactome DB_ID: 2564792
comment: Converted from EntitySet in Reactome

DPOD_YEAST
type: Protein
entity reference: P15436
data source: Provenance1
name: apo-POL3
name: DNA polymerase delta catalytic subunit ecNumber2.7.7.7/ecNumber
xref: UnificationXref6642
xref: UnificationXref6643
feature: FragmentFeature1073
cellular location: GO:0005829
comment: Reactome DB_ID: 2564774
display name: POL3

SequenceSite1179
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1178
type: SequenceSite
position status: EQUAL
sequence position: 351

SequenceSite1177
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1176
type: SequenceSite
position status: EQUAL
sequence position: 351

SequenceSite1175
type: SequenceSite
position status: EQUAL
sequence position: 2

RPB6_YEAST
type: Protein
entity reference: P9677.8
data source: Provenance1
name: DNA-directed RNA polymerases I, II, and III 23 kDa polypeptide
xref: UnificationXref7025
xref: UnificationXref7026
cellular location: GO:0005654
comment: Reactome DB_ID: 111834
display name: ABC23

DNA-directed RNA polymerase III 25 kDa polypeptide
type: Protein
entity reference: P35718
data source: Provenance1
name: RPCY_YEAST
xref: UnificationXref7024
xref: UnificationXref7023
cellular location: GO:0005654
comment: Reactome DB_ID: 111829
display name: C25

AC40
type: Protein
entity reference: RPC5
data source: Provenance1
name: DNA-directed RNA polymerases I and III 40 kDa polypeptide
name: RPC5_YEAST
xref: UnificationXref7020
xref: UnificationXref7021
cellular location: GO:0005654
comment: Reactome DB_ID: 111824
display name: C37

Hypothetical 18.6 kDa protein in CCT3-CCT8 intergenic region
type: Protein
entity reference: P47076
data source: Provenance1
xref: UnificationXref7019
xref: UnificationXref7018
cellular location: GO:0005654
comment: Reactome DB_ID: 111830
display name: YJB1_YEAST

RPC3_YEAST
type: Protein
entity reference: P9677.11
data source: Provenance1
name: DNA-directed RNA polymerase III 74 kDa polypeptide
xref: UnificationXref7028
xref: UnificationXref7029
cellular location: GO:0005654
comment: Reactome DB_ID: 111823
display name: C74

SequenceSite1184
type: SequenceSite
position status: EQUAL
sequence position: 379

Transcription factor tau 138 kDa subunit
type: Protein
entity reference: YAL001C
data source: Provenance1
name: TFIIIC 138 kDa subunit
xref: UnificationXref7000
xref: UnificationXref6999
cellular location: GO:0005654
comment: Reactome DB_ID: 111846
display name: TFC3_YEAST

SequenceSite1185
type: SequenceSite
position status: EQUAL
sequence position: 202

SequenceSite1182
type: SequenceSite
position status: EQUAL
sequence position: 204

SequenceSite1183
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1180
type: SequenceSite
position status: EQUAL
sequence position: 351

B-related factor
type: Protein
entity reference: P29056
data source: Provenance1
name: TFIIIB
name: Transcription factor IIIB 70 kDa subunit
xref: UnificationXref7013
xref: UnificationXref7014
cellular location: GO:0005654
comment: Reactome DB_ID: 111841
display name: BRF

SequenceSite1181
type: SequenceSite
position status: EQUAL
sequence position: 202

TATA binding factor
type: Protein
entity reference: P13393
data source: Provenance1
name: TATA-box binding protein
name: Transcription initiation factor TFIID TBP subunit
name: TATA sequence-binding protein
name: TATA-box factor
name: Transcription factor D
xref: UnificationXref7010
xref: UnificationXref7011
cellular location: GO:0005654
comment: Reactome DB_ID: 111843
display name: TBP

Transcription factor IIIA
type: Protein
entity reference: TFIIIA
data source: Provenance1
xref: UnificationXref7005
xref: UnificationXref7006
cellular location: GO:0005654
comment: Reactome DB_ID: 111840
display name: TFIIIA

THF-polyglutamate
type: SmallMoleculeReference
name: Tetrahydrofolyl-[Glu](n)
name: Tetrahydrofolyl-[Glu](n) [ChEBI:9484]
name: Tetrahydrofolyl-[Glu](n+1)
xref: UnificationXref5692

UniProt:P24000
type: ProteinReference
xref: UnificationXref1411
organism: BioSource1

Transcription factor tau 95 kDa subunit
type: Protein
entity reference: YBR123C
data source: Provenance1
name: TFIIIC 95 kDa subunit
xref: UnificationXref7002
xref: UnificationXref7003
cellular location: GO:0005654
comment: Reactome DB_ID: 111845
display name: TFC1_YEAST

SequenceSite1169
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1168
type: SequenceSite
position status: EQUAL
sequence position: 351

SequenceSite1165
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1164
type: SequenceSite
position status: EQUAL
sequence position: 737

SequenceSite1167
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1166
type: SequenceSite
position status: EQUAL
sequence position: 351

DNA-directed RNA polymerases I and III subunit RPAC1
type: Protein
entity reference: RPC5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DNA-directed RNA polymerase I and III 40 kDa polypeptide
name: HsRPAC1
name: POLR1C
name: P07703
name: RPA39
xref: UnificationXref6975
feature: FragmentFeature1124
cellular location: GO:0005654
comment: Reactome DB_ID: 3667598
display name: RPA40

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P28000 RPC19
data source: Provenance1
name: P28000
name: POLR1D
name: DNA-directed RNA polymerase I and III 16 kDa polypeptide
name: HsRPAC2
name: RPA16
name: DNA-directed RNA polymerases I and III subunit RPAC2
xref: UnificationXref6973
feature: FragmentFeature1123
cellular location: GO:0005654
comment: Reactome DB_ID: 3667595
display name: AC19

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P22138
data source: Provenance1
name: RPA135
name: DNA-directed RNA polymerase I 135 kDa polypeptide
name: P22138
name: RNA polymerase I subunit 2
xref: UnificationXref6979
feature: FragmentFeature1126
cellular location: GO:0005654
comment: Reactome DB_ID: 3667592
display name: POLR1B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P10964
data source: Provenance1
name: DNA-directed RNA polymerase I largest subunit
name: RNA polymerase I 194 kDa subunit
name: RPA194
name: P10964
xref: UnificationXref6977
feature: FragmentFeature1125
cellular location: GO:0005654
comment: Reactome DB_ID: 3667602
display name: POLR1A

Transcription factor TFIIIB B\" component
type: Protein
entity reference: P46678
data source: Provenance1
xref: UnificationXref6997
xref: UnificationXref6996
cellular location: GO:0005654
comment: Reactome DB_ID: 111842
display name: TFIIIB90

Transcription factor tau 131 kDa subunit
type: Protein
entity reference: P33339
data source: Provenance1
name: TFIIIC 131 kDa subunit
xref: UnificationXref6994
xref: UnificationXref6993
cellular location: GO:0005654
comment: Reactome DB_ID: 111847
display name: TFC4_YEAST

SequenceSite1171
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1172
type: SequenceSite
position status: EQUAL
sequence position: 404

SequenceSite1173
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1174
type: SequenceSite
position status: EQUAL
sequence position: 418

phospho-K48poluUb-phospho-PAK-2p34(Thr402)
type: Protein
entity reference: UniProt:Q12469
data source: Provenance1
xref: UnificationXref6954
feature: ModificationFeature188
feature: FragmentFeature1120
feature: ModificationFeature170
cellular location: GO:0005829
comment: Reactome DB_ID: 3670106

phospho-K48poluUb-phospho-PAK-2p34(Thr402)
type: Protein
entity reference: P48562
data source: Provenance1
xref: UnificationXref6953
feature: ModificationFeature187
feature: FragmentFeature1119
feature: ModificationFeature169
cellular location: GO:0005829
comment: Reactome DB_ID: 3670104

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P36070
data source: Provenance1
name: Rrn3
name: P36070
xref: UnificationXref6971
feature: FragmentFeature1122
cellular location: GO:0005654
comment: Reactome DB_ID: 3667588
display name: RRN3

SequenceSite1170
type: SequenceSite
position status: EQUAL
sequence position: 351

phospho-p-S318-PDE3B
type: Protein
entity reference: P06776
data source: Provenance1
xref: UnificationXref6965
feature: ModificationFeature189
feature: FragmentFeature1121
cellular location: GO:0005829
comment: Reactome DB_ID: 3668720

SequenceSite1199
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1198
type: SequenceSite
position status: EQUAL
sequence position: 187

SequenceSite1197
type: SequenceSite
position status: EQUAL
sequence position: 185

phospho-K48poluUb-phospho-PAK-2p34(Thr402)
type: Protein
entity reference: Q03497
data source: Provenance1
xref: UnificationXref6952
feature: ModificationFeature186
feature: ModificationFeature168
feature: FragmentFeature1118
cellular location: GO:0005829
comment: Reactome DB_ID: 3670102

Homologues of K48poluUb-phospho-PAK-2p34(Thr402)
type: Protein
data source: Provenance1
member physical entity: phospho-K48poluUb-phospho-PAK-2p34(Thr402)
xref: UnificationXref6955
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670107

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P54861
data source: Provenance1
name: DNM1L
name: P54861
xref: UnificationXref6946
feature: FragmentFeature1117
cellular location: GO:0005741
comment: Reactome DB_ID: 3670236
display name: Drp1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P54861
data source: Provenance1
name: DNM1L
name: P54861
xref: UnificationXref6945
feature: FragmentFeature1116
cellular location: GO:0005829
comment: Reactome DB_ID: 3670235
display name: Drp1

phospho-p-5S-PAK2(1-524)
type: Protein
entity reference: UniProt:Q12469
data source: Provenance1
xref: UnificationXref6938
feature: ModificationFeature184
feature: ModificationFeature183
feature: ModificationFeature181
feature: ModificationFeature185
feature: ModificationFeature182
feature: FragmentFeature1115
cellular location: GO:0005829
comment: Reactome DB_ID: 3670075

phospho-p-5S-PAK2(1-524)
type: Protein
entity reference: P48562
data source: Provenance1
xref: UnificationXref6937
feature: FragmentFeature1114
feature: ModificationFeature180
feature: ModificationFeature178
feature: ModificationFeature179
feature: ModificationFeature177
feature: ModificationFeature176
cellular location: GO:0005829
comment: Reactome DB_ID: 3670069

phospho-p-5S-PAK2(1-524)
type: Protein
entity reference: Q03497
data source: Provenance1
xref: UnificationXref6936
feature: ModificationFeature174
feature: ModificationFeature172
feature: ModificationFeature171
feature: FragmentFeature1113
feature: ModificationFeature173
feature: ModificationFeature175
cellular location: GO:0005829
comment: Reactome DB_ID: 3670063

Homologues of p-5S-PAK2(1-524)
type: Protein
data source: Provenance1
member physical entity: phospho-p-5S-PAK2(1-524)
xref: UnificationXref6939
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670076

Procainamide [ChEBI:8428]
type: SmallMoleculeReference
name: Procainamide
xref: UnificationXref331

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q12469
data source: Provenance1
name: Q12469
name: PAK2(1-524)
xref: UnificationXref6934
feature: FragmentFeature1112
cellular location: GO:0005829
comment: Reactome DB_ID: 3670056
display name: PAK2

http://identifiers.org/pubmed/8163052
type: PublicationXref
id: 8163052
author: Gomis, R
author: Malaisse, WJ
author: Sener, A
author: Fernandez-Alvarez, J
author: Conget, I
author: Rasschaert, J
db: Pubmed
title: Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients
source: Diabetologia 37:177-81
year: 1994

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P48562
data source: Provenance1
name: P48562
name: PAK2(1-524)
xref: UnificationXref6933
feature: FragmentFeature1111
cellular location: GO:0005829
comment: Reactome DB_ID: 3670052
display name: PAK2

http://identifiers.org/pubmed/15080793
type: PublicationXref
id: 15080793
author: Wenk, MR
author: Uhlén, P
author: Lee, E
author: De Camilli, P
author: Ehrlich, BE
author: Degray, B
author: Johenning, FW
db: Pubmed
title: InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1
source: Biochem J 382:687-94
year: 2004

SequenceSite1187
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1186
type: SequenceSite
position status: EQUAL
sequence position: 204

SequenceSite1189
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/15359280
type: PublicationXref
id: 15359280
author: Truscott, KN
author: Chacinska, A
author: Guiard, B
author: Meisinger, C
author: Kozjak, V
author: Pfannschmidt, S
author: Schulze-Specking, A
author: Sanjuán Szklarz, LK
author: Pfanner, N
author: Wiedemann, N
db: Pubmed
title: Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins
source: EMBO J 23:3735-46
year: 2004

SequenceSite1188
type: SequenceSite
position status: EQUAL
sequence position: 379

Phosphatidylinositol-3,4,5-trisphosphate
type: SmallMoleculeReference
name: PIP3
name: PtsIns(3,4,5)P3
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]
name: PtsIns-3,4,5-P3
name: 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
xref: UnificationXref8504

Axonal growth inhibition (RHOA activation)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction730
evidence: Evidence1141
xref: UnificationXref8561
xref: RelationshipXref1053
xref: UnificationXref8562
pathway order: PathwayStep1147
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

phospho-p-T402-PAK2(1-524)
type: Protein
entity reference: UniProt:Q12469
data source: Provenance1
xref: UnificationXref6928
feature: FragmentFeature1109
feature: ModificationFeature170
cellular location: GO:0005654
comment: Reactome DB_ID: 3670098

phospho-p-T402-PAK2(1-524)
type: Protein
entity reference: P48562
data source: Provenance1
xref: UnificationXref6927
feature: FragmentFeature1108
feature: ModificationFeature169
cellular location: GO:0005654
comment: Reactome DB_ID: 3670097

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q03497
data source: Provenance1
name: Q03497
name: PAK2(1-524)
xref: UnificationXref6932
feature: FragmentFeature1110
cellular location: GO:0005829
comment: Reactome DB_ID: 3670048
display name: PAK2

Homologues of PAK2(1-524)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref6935
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670057

phospho-p-T402-PAK2(213-524)
type: Protein
entity reference: UniProt:Q12469
data source: Provenance1
xref: UnificationXref6922
feature: FragmentFeature1106
feature: ModificationFeature170
cellular location: GO:0005829
comment: Reactome DB_ID: 3670088

phospho-p-T402-PAK2(213-524)
type: Protein
entity reference: P48562
data source: Provenance1
xref: UnificationXref6921
feature: FragmentFeature1105
feature: ModificationFeature169
cellular location: GO:0005829
comment: Reactome DB_ID: 3670086

phospho-p-T402-PAK2(1-524)
type: Protein
entity reference: Q03497
data source: Provenance1
xref: UnificationXref6926
feature: ModificationFeature168
feature: FragmentFeature1107
cellular location: GO:0005654
comment: Reactome DB_ID: 3670096

Homologues of p-T402-PAK2(1-524)
type: Protein
data source: Provenance1
member physical entity: phospho-p-T402-PAK2(1-524)
xref: UnificationXref6929
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670099

SequenceSite1190
type: SequenceSite
position status: EQUAL
sequence position: 379

3-Methyl-2-oxopentanoate
type: SmallMoleculeReference
name: 2-Oxo-3-methylvalerate
name: 3-Methyl-2-oxopentanoate [ChEBI:28654]
xref: UnificationXref5865

SequenceSite1191
type: SequenceSite
position status: EQUAL
sequence position: 2

phospho-p-T402-PAK2(213-524)
type: Protein
entity reference: Q03497
data source: Provenance1
xref: UnificationXref6920
feature: ModificationFeature168
feature: FragmentFeature1104
cellular location: GO:0005829
comment: Reactome DB_ID: 3670084

SequenceSite1192
type: SequenceSite
position status: EQUAL
sequence position: 379

Homologues of p-T402-PAK2(213-524)
type: Protein
data source: Provenance1
member physical entity: phospho-p-T402-PAK2(213-524)
xref: UnificationXref6923
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670089

SequenceSite1193
type: SequenceSite
position status: EQUAL
sequence position: 185

SequenceSite1194
type: SequenceSite
position status: EQUAL
sequence position: 187

SequenceSite1195
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1196
type: SequenceSite
position status: EQUAL
sequence position: 360

UnificationXref3730
type: UnificationXref
id: 29460
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29460

http://identifiers.org/pubmed/10843998
type: PublicationXref
id: 10843998
author: Koduru, SB
author: Hamada, M
author: Sakulich, AL
author: Maraia, RJ
db: Pubmed
title: Transcription termination by RNA polymerase III in fission yeast. A genetic and biochemically tractable model system.
source: J Biol Chem 275:29076-81
year: 2000

http://identifiers.org/pubmed/12640110
type: PublicationXref
id: 12640110
author: Rapaport, D
author: Neupert, W
author: Brix, J
author: Stan, T
author: Schneider-Mergener, J
author: Pfanner, N
db: Pubmed
title: Mitochondrial protein import: recognition of internal import signals of BCS1 by the TOM complex
source: Mol Cell Biol 23:2239-50
year: 2003

UnificationXref3735
type: UnificationXref
id: P10614
db: UniProt

UnificationXref3736
type: UnificationXref
id: 3669422
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669422

UnificationXref3737
type: UnificationXref
id: 3669424
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669424

UnificationXref3738
type: UnificationXref
id: REACT_79266
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79266.9

UnificationXref3731
type: UnificationXref
id: REACT_4966
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4966.2

UnificationXref3732
type: UnificationXref
id: CHEBI:17813
db: ChEBI

UnificationXref3733
type: UnificationXref
id: 194644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194644

UnificationXref3734
type: UnificationXref
id: REACT_10253
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10253.1

PublicationXref1101
type: PublicationXref
id: 9780849387326
author: Clarke, CF
author: Jonassen, T
db: ISBN
title: Genetic Analysis of Coenzyme Q Biosynthesis
source: Coenzyme Q: Molecular Mechanisms in Health and Disease (Book): 185-208
year: 2000

UniProt:Q12690
type: ProteinReference
xref: UnificationXref1571
organism: BioSource1

UnificationXref3739
type: UnificationXref
id: GO:0005635
db: GENE ONTOLOGY

http://identifiers.org/pubmed/6434529
type: PublicationXref
id: 6434529
author: Chuang, DT
author: Cox, RP
author: Markovitz, PJ
db: Pubmed
title: Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.
source: J Biol Chem 259:11643-6
year: 1984

Chenodeoxycholoyl-CoA [ChEBI:28701]
type: SmallMoleculeReference
name: Chenodeoxycholoyl-CoA
xref: UnificationXref4017

UnificationXref3726
type: UnificationXref
id: 3669270
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669270

UnificationXref3727
type: UnificationXref
id: 3669272
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669272

UnificationXref3724
type: UnificationXref
id: REACT_10504
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10504.2

UnificationXref3725
type: UnificationXref
id: P38604
db: UniProt

UnificationXref3722
type: UnificationXref
id: CHEBI:16521
db: ChEBI

UnificationXref3723
type: UnificationXref
id: 194634
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194634

UnificationXref3720
type: UnificationXref
id: 3669234
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669234

UnificationXref3721
type: UnificationXref
id: REACT_31775
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31775.10

UnificationXref3729
type: UnificationXref
id: CHEBI:30751
db: ChEBI

UnificationXref3728
type: UnificationXref
id: REACT_86645
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86645.9

UnificationXref3750
type: UnificationXref
id: REACT_10513
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10513.1

UnificationXref3751
type: UnificationXref
id: P32462
db: UniProt

UnificationXref3752
type: UnificationXref
id: 3669416
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669416

UnificationXref3753
type: UnificationXref
id: 3669418
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669418

UnificationXref3754
type: UnificationXref
id: REACT_90470
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90470.9

UnificationXref3755
type: UnificationXref
id: 194633
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194633

UnificationXref3756
type: UnificationXref
id: REACT_10958
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10958.1

http://identifiers.org/pubmed/15720390
type: PublicationXref
id: 15720390
author: Fabre, AL
author: Orlean, P
author: Taron, CH
db: Pubmed
title: Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly
source: FEBS J 272:1160-8
year: 2005

UnificationXref3757
type: UnificationXref
id: 3669426
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669426

UnificationXref3758
type: UnificationXref
id: 3669428
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669428

UnificationXref3759
type: UnificationXref
id: REACT_105788
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105788.9

UnificationXref3740
type: UnificationXref
id: 194725
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194725

UnificationXref3741
type: UnificationXref
id: REACT_10783
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10783.1

UniProt:P28000 RPC19
type: ProteinReference
name: RPC19
name: N1937
name: YNL113W
xref: UnificationXref6972
comment: FUNCTION DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.SUBUNIT Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of 14 and 17 subunits, respectively. Interacts with the AC40 subunit.MISCELLANEOUS Present with 8680 molecules/cell in log phase SD medium.SIMILARITY Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
organism: BioSource1

UnificationXref3744
type: UnificationXref
id: 194688
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194688

UnificationXref3745
type: UnificationXref
id: REACT_10528
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10528.1

UnificationXref3742
type: UnificationXref
id: 194681
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194681

UnificationXref3743
type: UnificationXref
id: REACT_10169
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10169.1

UnificationXref3748
type: UnificationXref
id: REACT_10787
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10787.1

UnificationXref3749
type: UnificationXref
id: 194668
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194668

UnificationXref3746
type: UnificationXref
id: CHEBI:18364
db: ChEBI

UnificationXref3747
type: UnificationXref
id: 194704
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194704

http://identifiers.org/pubmed/8755247
type: PublicationXref
id: 8755247
author: Migliaccio, E
author: Bonfini, L
author: Pelicci, PG
author: Pelicci, G
author: Lanfrancone, L
db: Pubmed
title: Not all Shc's roads lead to Ras
source: Trends Biochem Sci 21:257-61
year: 1996

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32773
data source: Provenance1
name: Transcription Factor IIA beta chain - p19
name: GTF2A1(275-376)
xref: UnificationXref7170
feature: FragmentFeature1140
cellular location: GO:0005654
comment: Reactome DB_ID: 3667803
display name: P32773

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32773
data source: Provenance1
name: Transcription Factor IIA alpha chain - p35
name: GTF2A1(1-274)
xref: UnificationXref7169
feature: FragmentFeature1139
cellular location: GO:0005654
comment: Reactome DB_ID: 3667802
display name: P32773

TFIIA-gamma
type: Protein
entity reference: P32774
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: TFIIA P12 subunit
name: Transcription initiation factor IIA gamma chain
name: P32774
name: TFIIA-12
name: TFIIAS
xref: UnificationXref7167
feature: FragmentFeature1138
cellular location: GO:0005654
comment: Reactome DB_ID: 3667807
display name: GTF2A2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P11747
data source: Provenance1
name: Transcription initiation factor TFIID 18 kDa subunit
name: P11747
name: TAFII18
name: TAFII-18
xref: UnificationXref7164
feature: FragmentFeature1137
cellular location: GO:0005654
comment: Reactome DB_ID: 3667822
display name: TAF13

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P53040
data source: Provenance1
name: TAFII80
name: P53040
name: Transcription initiation factor TFIID 70 kDa subunit
name: TAFII-70
name: TAFII-80
xref: UnificationXref7161
feature: FragmentFeature1136
cellular location: GO:0005654
comment: Reactome DB_ID: 3667842
display name: TAF6

Homologues of GARS(55-739)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7294
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670376

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38707
data source: Provenance1
name: NARS(2-548)
name: Asparaginyl-tRNA synthetase
name: P38707
xref: UnificationXref7270
feature: FragmentFeature1143
cellular location: GO:0005829
comment: Reactome DB_ID: 3670352
display name: NARS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P53852
data source: Provenance1
name: Cysteinyl-tRNA synthetase
name: P53852
xref: UnificationXref7280
feature: FragmentFeature1144
cellular location: GO:0005829
comment: Reactome DB_ID: 3670331
display name: CARS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P29055
data source: Provenance1
name: General transcription factor TFIIB
name: P29055
name: S300-II
name: TFIIB
name: Transcription initiation factor IIB
name: Transcription initiation factor IIB (General transcription factor TFIIB) (S300-II)
xref: UnificationXref7173
feature: FragmentFeature1141
cellular location: GO:0005654
comment: Reactome DB_ID: 3667812
display name: GTF2B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P40825
data source: Provenance1
name: Alanyl-tRNA synthetase
name: P40825
xref: UnificationXref7260
feature: FragmentFeature1142
cellular location: GO:0005829
comment: Reactome DB_ID: 3670325
display name: AARS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P15624
data source: Provenance1
name: Phenylalanyl-tRNA synthetase beta chain
name: P15624
xref: UnificationXref7307
feature: FragmentFeature1148
cellular location: GO:0005829
comment: Reactome DB_ID: 3670318
display name: FARSB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P15625
data source: Provenance1
name: P15625
name: Phenylalanyl-tRNA synthetase alpha chain
xref: UnificationXref7305
feature: FragmentFeature1147
cellular location: GO:0005829
comment: Reactome DB_ID: 3670314
display name: FARSA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P04801
data source: Provenance1
name: P04801
name: Threonyl-tRNA synthetase
xref: UnificationXref7329
feature: FragmentFeature1150
cellular location: GO:0005829
comment: Reactome DB_ID: 3670358
display name: TARS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P07284
data source: Provenance1
name: Seryl-tRNA synthetase
name: SARS(2-514)
name: P07284
xref: UnificationXref7318
feature: FragmentFeature1149
cellular location: GO:0005829
comment: Reactome DB_ID: 3670345
display name: SARS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q06817
data source: Provenance1
name: Glycyl-tRNA synthetase
name: Q06817
name: GARS(55-739)
xref: UnificationXref7293
feature: FragmentFeature1146
cellular location: GO:0005829
comment: Reactome DB_ID: 3670375
display name: GARS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P38088
data source: Provenance1
name: Glycyl-tRNA synthetase
name: P38088
name: GARS(55-739)
xref: UnificationXref7291
feature: FragmentFeature1145
cellular location: GO:0005829
comment: Reactome DB_ID: 3670371
display name: GARS

http://identifiers.org/pubmed/11742412
type: PublicationXref
id: 11742412
author: Saltiel, AR
author: Kahn, CR
db: Pubmed
title: Insulin signalling and the regulation of glucose and lipid metabolism
source: Nature 414:799-806
year: 2001

http://identifiers.org/pubmed/18660845
type: PublicationXref
id: 18660845
author: Zhao, FQ
author: Keating, AF
db: Pubmed
title: Functional properties and genomics of glucose transporters
source: Curr Genomics 8:113-28
year: 2007

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q12109
data source: Provenance1
name: Q12109
name: WARS(2-471)
name: Tryptophanyl-tRNA synthetase
xref: UnificationXref7340
feature: FragmentFeature1151
cellular location: GO:0005829
comment: Reactome DB_ID: 3670338
display name: WARS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P07806
data source: Provenance1
name: P07806
name: Valyl-tRNA synthetase
xref: UnificationXref7351
feature: FragmentFeature1152
cellular location: GO:0005829
comment: Reactome DB_ID: 3670365
display name: VARS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P40825
data source: Provenance1
name: Alanyl-tRNA synthetase 2
name: P40825
xref: UnificationXref7360
feature: FragmentFeature1153
cellular location: GO:0005759
comment: Reactome DB_ID: 3670399
display name: AARS2

Homologues of RARS2
type: Protein
data source: Provenance1
member physical entity: Protein1430
member physical entity: Protein1431
xref: UnificationXref7373
cellular location: GO:0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670446

UnificationXref3710
type: UnificationXref
id: 29368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29368

UnificationXref3712
type: UnificationXref
id: CHEBI:15441
db: ChEBI

UnificationXref3711
type: UnificationXref
id: REACT_5251
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5251.2

UnificationXref3714
type: UnificationXref
id: REACT_9761
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9761.1

UnificationXref3713
type: UnificationXref
id: 191309
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191309

UnificationXref3716
type: UnificationXref
id: 3669231
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669231

UnificationXref3715
type: UnificationXref
id: P32476
db: UniProt

UniProt:Q12675
type: ProteinReference
xref: UnificationXref8439
organism: BioSource1

UnificationXref3717
type: UnificationXref
id: 29386
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29386

PublicationXref1120
type: PublicationXref
id: 0781721458
author: Marks, AL
author: Smith, C
author: Lieberman, M
db: ISBN
title: Pathways of Sugar Metabolism
source: Basic Medical Biochemistry: A Clinical Approach, 2nd ed (Book): 527
year: 2005

UnificationXref3718
type: UnificationXref
id: REACT_4227
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4227.1

UniProt:Q12672
type: ProteinReference
xref: UnificationXref1404
organism: BioSource1

UnificationXref3719
type: UnificationXref
id: 3669232
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669232

UnificationXref3701
type: UnificationXref
id: 3669291
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669291

UnificationXref3700
type: UnificationXref
id: 3669290
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669290

UnificationXref3705
type: UnificationXref
id: 191269
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191269

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32914
data source: Provenance1
name: SPT4H1 protein
name: Transcription initiation protein SPT4 homolog 1
name: SUPT4H1
xref: UnificationXref7123
feature: FragmentFeature1127
cellular location: GO:0005654
comment: Reactome DB_ID: 3668564
display name: P32914

http://identifiers.org/pubmed/12669019
type: PublicationXref
id: 12669019
author: Desjardins, M
db: Pubmed
title: ER-mediated phagocytosis: a new membrane for new functions
source: Nat Rev Immunol 3:280-91
year: 2003

UnificationXref3704
type: UnificationXref
id: CHEBI:15440
db: ChEBI

DNA-directed RNA polymerases I, II, and III 27 kDa polypeptide
type: Protein
entity reference: UniProt:P20434 RPB5
data source: Provenance1
name: RPB5_YEAST
xref: UnificationXref7058
xref: UnificationXref7057
cellular location: GO:0005654
comment: Reactome DB_ID: 111833
display name: ABC27

UnificationXref3703
type: UnificationXref
id: REACT_93181
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93181.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P36100
data source: Provenance1
name: TFIIE-alpha
name: Transcription initiation factor IIE, alpha subunit
name: General transcription factor IIE 56 kDa subunit
name: P36100
xref: UnificationXref7141
feature: FragmentFeature1129
cellular location: GO:0005654
comment: Reactome DB_ID: 3667852
display name: GTF2E1

UnificationXref3702
type: UnificationXref
id: 3669294
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669294

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q03254
data source: Provenance1
name: Q03254
name: FCP1P protein
xref: UnificationXref7134
feature: FragmentFeature1128
cellular location: GO:0005654
comment: Reactome DB_ID: 3668570
display name: CTDP1

http://identifiers.org/pubmed/6434534
type: PublicationXref
id: 6434534
author: Gracy, RW
author: Yuan, PM
author: Lu, HS
db: Pubmed
title: Primary structure of human triosephosphate isomerase
source: J Biol Chem 259:11958-68
year: 1984

UnificationXref3708
type: UnificationXref
id: REACT_96060
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96060.9

Transcription initiation factor TFIID 100 kDa subunit
type: Protein
entity reference: P38129
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P38129
name: TAFII100
name: TAFII-100
xref: UnificationXref7148
feature: FragmentFeature1130
cellular location: GO:0005654
comment: Reactome DB_ID: 3667816
display name: TAF5

UnificationXref3709
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q05027
data source: Provenance1
name: TAFII31
name: Q05027
xref: UnificationXref7150
feature: FragmentFeature1131
cellular location: GO:0005654
comment: Reactome DB_ID: 3667847
display name: TAF9

UnificationXref3706
type: UnificationXref
id: REACT_9771
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9771.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q12030
data source: Provenance1
name: TAFII30
name: STAF28
name: TAFII-30
name: Transcription initiation factor TFIID 30 kDa subunit
name: Q12030
xref: UnificationXref7152
feature: FragmentFeature1132
cellular location: GO:0005654
comment: Reactome DB_ID: 3667838
display name: TAF10

UnificationXref3707
type: UnificationXref
id: 3669293
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669293

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q04226
data source: Provenance1
name: TAFII-28
name: TAFII28
name: TFIID subunit p30-beta
name: Q04226
name: Transcription initiation factor TFIID 28 kDa subunit
xref: UnificationXref7155
feature: FragmentFeature1133
cellular location: GO:0005654
comment: Reactome DB_ID: 3667834
display name: TAF11

TAFII20/TAFII15
type: Protein
entity reference: Q03761
data source: Provenance1
name: TAFII- 20/TAFII-15
name: Note: the coordinates are copied over from Homo sapiens.
name: Transcription initiation factor TFIID 20/15 kDa subunits
name: Q03761
xref: UnificationXref7157
feature: FragmentFeature1134
cellular location: GO:0005654
comment: Reactome DB_ID: 3667826
display name: TAF12

P46677
type: Protein
entity reference: P46677
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: TAFII250
name: Transcription initiation factor TFIID 250 kDa subunit
name: Cell cycle gene 1 protein
name: TBP-associated factor 250 kDa
name: TAFII-250
name: P250
xref: UnificationXref7159
feature: FragmentFeature1135
cellular location: GO:0005654
comment: Reactome DB_ID: 3667830
display name: TAF1

http://identifiers.org/pubmed/15274629
type: PublicationXref
id: 15274629
author: Takeuchi, N
author: Heck, A
author: Spencer, AC
author: Watanabe, K
author: Spremulli, LL
db: Pubmed
title: Characterization of the human mitochondrial methionyl-tRNA synthetase
source: Biochemistry 43:9743-54
year: 2004

http://identifiers.org/pubmed/7354069
type: PublicationXref
id: 7354069
author: Anderson, PM
author: Desnick, RJ
db: Pubmed
title: Purification and properties of uroporphyrinogen I synthase from human erythrocytes. Identification of stable enzyme-substrate intermediates.
source: J Biol Chem 255:1993-9
year: 1980

PublicationXref1180
type: PublicationXref
author: Michal, G
title: Biochemical Pathways - An Atlas of Biochemistry and Molecular Biology
source: 193-200
year: 1999

PublicationXref1181
type: PublicationXref
author: Metzler, DE
title: Biochemistry - The Chemical Reactions of Living Cells 2nd Edn.
source: 2:1018-84
year: 2003

http://identifiers.org/pubmed/17331073
type: PublicationXref
id: 17331073
author: Wei, Y
author: Hornemann, T
author: von Eckardstein, A
db: Pubmed
title: Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?
source: Biochem J 405:157-64
year: 2007

http://identifiers.org/pubmed/14739303
type: PublicationXref
id: 14739303
author: Su, Xiaoqin
author: Shu, Hong-Bing
author: Han, Ke-Jun
author: Zhang, Jun
author: Bin, Liang-Hua
author: Xu, Liang-Guo
db: Pubmed
title: Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways
source: J. Biol. Chem. 279:15652-61
year: 2004

http://identifiers.org/pubmed/7354072
type: PublicationXref
id: 7354072
author: Bodlaender, P
author: Shemin, D
author: Bevan, DR
db: Pubmed
title: Mechanism of porphobilinogen synthase. Requirement of Zn2+ for enzyme activity.
source: J Biol Chem 255:2030-5
year: 1980

Catalysis2
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction2
control type: ACTIVATION
xref: RelationshipXref2
xref: RelationshipXref1
controller: Protein3

Catalysis1
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction1
control type: ACTIVATION
xref: RelationshipXref2
xref: RelationshipXref1
controller: Protein3

Catalysis6
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction6
control type: ACTIVATION
xref: RelationshipXref4
xref: RelationshipXref3
controller: Complex1

Catalysis5
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction5
control type: ACTIVATION
xref: RelationshipXref4
xref: RelationshipXref3
controller: Complex1

Catalysis4
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction4
control type: ACTIVATION
xref: RelationshipXref4
xref: RelationshipXref3
controller: Complex1

Catalysis3
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction3
control type: ACTIVATION
xref: RelationshipXref2
xref: RelationshipXref1
controller: Protein3

Catalysis9
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction9
control type: ACTIVATION
xref: RelationshipXref12
xref: RelationshipXref11
controller: Protein16

Catalysis8
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction8
control type: ACTIVATION
xref: RelationshipXref9
xref: RelationshipXref8
controller: Protein15

Catalysis7
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction7
control type: ACTIVATION
xref: RelationshipXref6
xref: RelationshipXref5
controller: Complex1

PublicationXref1179
type: PublicationXref
author: Cox, MM
author: Nelson, DL
title: Lehninger - Principles of Biochemistry 4th Edn.
source: 690-750
year: 2005

PublicationXref1176
type: PublicationXref
author: Nicholls, DG
author: Ferguson, SJ
title: Bioenergetics 3
source: 89-134
year: 2002

PublicationXref1177
type: PublicationXref
author: Murray, RK
title: Harper's Biochemistry 25th Edn.
source: 137-48

Rho GTPase cycle
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction732
pathway component: BiochemicalReaction735
pathway component: BiochemicalReaction734
pathway component: BiochemicalReaction733
evidence: Evidence1170
xref: UnificationXref8690
xref: RelationshipXref1064
xref: UnificationXref8689
pathway order: PathwayStep1175
pathway order: PathwayStep1176
pathway order: PathwayStep1173
pathway order: PathwayStep1174
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Transport of inorganic cations/anions and amino acids/oligopeptides
type: Pathway
data source: Provenance1
pathway component: REACT 36513.10
pathway component: REACT 109449.9
pathway component: BiochemicalReaction576
pathway component: REACT 125786.5
pathway component: REACT 154820.3
evidence: Evidence1062
xref: UnificationXref8143
xref: RelationshipXref1002
xref: UnificationXref8144
pathway order: PathwayStep870
pathway order: PathwayStep876
pathway order: PathwayStep872
pathway order: PathwayStep871
pathway order: PathwayStep1069
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3779
type: UnificationXref
id: Q12452
db: UniProt

UnificationXref3778
type: UnificationXref
id: REACT_10930
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10930.1

UnificationXref3777
type: UnificationXref
id: 194723
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194723

UnificationXref3776
type: UnificationXref
id: CHEBI:63841
db: ChEBI

UnificationXref3775
type: UnificationXref
id: REACT_113553
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113553.8

UnificationXref3774
type: UnificationXref
id: 3669411
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669411

UnificationXref3773
type: UnificationXref
id: 3669409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669409

UnificationXref3772
type: UnificationXref
id: P53199
db: UniProt

UnificationXref3771
type: UnificationXref
id: REACT_10464
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10464.1

UnificationXref3770
type: UnificationXref
id: 194667
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194667

Role of LAT2/NTAL/LAB on calcium mobilization
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction784
pathway component: REACT 149929.4
evidence: Evidence1347
xref: UnificationXref9328
xref: UnificationXref9327
pathway order: PathwayStep205
pathway order: PathwayStep1286
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3769
type: UnificationXref
id: CHEBI:50593
db: ChEBI

UnificationXref3768
type: UnificationXref
id: REACT_5115
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5115.1

UnificationXref3765
type: UnificationXref
id: 3669405
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669405

UnificationXref3764
type: UnificationXref
id: 3669403
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669403

UnificationXref3767
type: UnificationXref
id: 73473
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73473

UnificationXref3766
type: UnificationXref
id: REACT_89551
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89551.9

UnificationXref3761
type: UnificationXref
id: 194735
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194735

UnificationXref3760
type: UnificationXref
id: CHEBI:63842
db: ChEBI

UnificationXref3763
type: UnificationXref
id: P53045
db: UniProt

UnificationXref3762
type: UnificationXref
id: REACT_10298
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10298.1

UnificationXref3799
type: UnificationXref
id: 195691
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=195691

UnificationXref3798
type: UnificationXref
id: CHEBI:16290
db: ChEBI

UnificationXref3797
type: UnificationXref
id: REACT_106908
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106908.9

UnificationXref3792
type: UnificationXref
id: REACT_112960
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112960.8

UnificationXref3791
type: UnificationXref
id: 3669429
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669429

UnificationXref3790
type: UnificationXref
id: REACT_10977
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10977.1

UnificationXref3796
type: UnificationXref
id: 3669399
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669399

http://identifiers.org/pubmed/9548747
type: PublicationXref
id: 9548747
author: Hammond, PW
author: Cech, TR
db: Pubmed
title: Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation
source: Biochemistry 37:5162-72
year: 1998

UnificationXref3795
type: UnificationXref
id: REACT_10642
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10642.2

UnificationXref3794
type: UnificationXref
id: 194691
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194691

UnificationXref3793
type: UnificationXref
id: CHEBI:18252
db: ChEBI

Downstream signal transduction
type: Pathway
data source: Provenance1
pathway component: REACT 107261.9
pathway component: REACT 112309.8
pathway component: REACT 149929.4
evidence: Evidence1155
xref: UnificationXref8590
xref: UnificationXref8591
pathway order: PathwayStep191
pathway order: PathwayStep200
pathway order: PathwayStep205
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3787
type: UnificationXref
id: REACT_32840
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32840.10

UnificationXref3786
type: UnificationXref
id: 3669412
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669412

UnificationXref3789
type: UnificationXref
id: 194661
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194661

UnificationXref3788
type: UnificationXref
id: CHEBI:52386
db: ChEBI

UnificationXref3781
type: UnificationXref
id: 3669425
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669425

UnificationXref3780
type: UnificationXref
id: 3669397
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669397

UnificationXref3783
type: UnificationXref
id: CHEBI:63844
db: ChEBI

UnificationXref3782
type: UnificationXref
id: REACT_97126
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97126.9

UnificationXref3785
type: UnificationXref
id: REACT_10167
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10167.1

UnificationXref3784
type: UnificationXref
id: 194657
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194657

http://identifiers.org/pubmed/9045610
type: PublicationXref
id: 9045610
author: Weaver, PL
author: Chuang, RY
author: Chang, TH
author: Liu, Z
db: Pubmed
title: Requirement of the DEAD-Box protein ded1p for messenger RNA translation.
source: Science 275:1468-71
year: 1997

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P53312
data source: Provenance1
name: Succinyl-CoA synthetase, betaA chain
name: P53312
xref: UnificationXref4894
feature: FragmentFeature894
cellular location: GO:0005759
comment: Reactome DB_ID: 3666432
display name: SUCLA2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P28241
data source: Provenance1
name: Isocitrate dehydrogenase (NAD) subunit alpha, mitochondrial precursor
name: isocitrate dehydrogenase 3 (NAD+) alpha
name: NAD+-specific ICDH
name: P28241
name: Isocitric dehydrogenase
xref: UnificationXref4870
feature: FragmentFeature889
cellular location: GO:0005759
comment: Reactome DB_ID: 3666376
display name: IDH3A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P19414
data source: Provenance1
name: aconitase 2, mitochondrial
name: Aconitase
name: Aconitate hydratase, mitochondrial precursor
name: Citrate hydro-lyase
name: P19414
xref: UnificationXref4864
feature: FragmentFeature888
cellular location: GO:0005759
comment: Reactome DB_ID: 3666387
display name: ACO2

isocitrate dehydrogenase 3 (NAD+) gamma
type: Protein
entity reference: YNL037C
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Isocitrate dehydrogenase (NAD) subunit gamma, mitochondrial precursor
name: NAD+-specific ICDH
name: P28834
name: Isocitric dehydrogenase
xref: UnificationXref4872
feature: FragmentFeature891
cellular location: GO:0005759
comment: Reactome DB_ID: 3666380
display name: IDH3G

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: YNL037C
data source: Provenance1
name: NAD+-specific ICDH
name: Isocitrate dehydrogenase (NAD) subunit beta, mitochondrial precursor
name: isocitrate dehydrogenase 3 (NAD+) beta
name: P28834
name: Isocitric dehydrogenase
xref: UnificationXref4871
feature: FragmentFeature890
cellular location: GO:0005759
comment: Reactome DB_ID: 3666379
display name: IDH3B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32473
data source: Provenance1
name: Pyruvate dehydrogenase E1 component beta subunit, mitochondrial precursor
name: ODPA_HUMAN
name: PDHE1-B
name: pyruvate dehydrogenase E1 beta apoprotein
name: P32473
xref: UnificationXref4848
feature: FragmentFeature885
cellular location: GO:0005759
comment: Reactome DB_ID: 3666547
display name: PDHB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P16387
data source: Provenance1
name: ODPA_HUMAN
name: P16387
name: pyruvate dehydrogenase E1 alpha apoprotein
name: Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor
name: PDHE1-A type I
xref: UnificationXref4844
feature: FragmentFeature884
cellular location: GO:0005759
comment: Reactome DB_ID: 3666543
display name: PDHA1

http://identifiers.org/pubmed/3129195
type: PublicationXref
id: 3129195
author: Baeuerle, PA
author: Baltimore, D
db: Pubmed
title: Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor
source: Cell 53:211-7
year: 1988

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P12695
data source: Provenance1
name: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
name: ODP2_HUMAN
name: PBC
name: pyruvate dehydrogenase E2 subunit
name: PDC-E2
name: 2xLipo-DLAT
name: P12695
name: M2 antigen complex 70 kDa subunit
name: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor
name: 70 kDa mitochondrial autoantigen of primary biliary cirrhosis
xref: UnificationXref4854
feature: FragmentFeature887
feature: ModificationFeature145
feature: ModificationFeature146
cellular location: GO:0005759
comment: Reactome DB_ID: 3666554
display name: E2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P16451
data source: Provenance1
name: proX
name: E3-binding protein
name: P16451
name: Pyruvate dehydrogenase protein X component, mitochondrial precursor
name: E3BP
name: ODPX_HUMAN
name: Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex
name: pyruvate dehydrogenase complex X component (E3 binding protein)
xref: UnificationXref4851
feature: FragmentFeature886
cellular location: GO:0005759
comment: Reactome DB_ID: 3666559
display name: PDHX

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P20967
data source: Provenance1
name: 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor
name: P20967
name: 2-oxoglutarate dehydrogenase E1
name: ODO1_HUMAN
name: Alpha-ketoglutarate dehydrogenase
name: alpha-ketoglutarate dehydrogenase E1 apoenzyme
xref: UnificationXref4887
feature: FragmentFeature893
cellular location: GO:0005759
comment: Reactome DB_ID: 3666439
display name: OGDH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P19262
data source: Provenance1
name: alpha-ketoglutarate dehydrogenase E2
name: P19262
name: Dihydrolipoamide succinyltransferase
name: Lipo-DLST
xref: UnificationXref4881
feature: FragmentFeature892
feature: ModificationFeature147
cellular location: GO:0005759
comment: Reactome DB_ID: 3666446
display name: DLST

P53311
type: Protein
entity reference: P53311
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Mitochondrial pyruvate carrier 2
name: BRP44
xref: UnificationXref4830
feature: FragmentFeature880
cellular location: GO:0005743
comment: Reactome DB_ID: 3670273
display name: MPC2

Homologues of MPC2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P53311
xref: UnificationXref4833
cellular location: GO:0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670278

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P07807
data source: Provenance1
name: Dihydrofolate reductase
name: DYR_HUMAN
name: P07807
xref: UnificationXref4819
feature: FragmentFeature879
cellular location: GO:0005829
comment: Reactome DB_ID: 3669637
display name: DHFR

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P51601
data source: Provenance1
name: GTP cyclohydrolase 1
name: P51601
name: GCH1_HUMAN
xref: UnificationXref4806
feature: FragmentFeature878
cellular location: GO:0005829
comment: Reactome DB_ID: 3672102
display name: GCH1

http://identifiers.org/pubmed/18772396
type: PublicationXref
id: 18772396
author: Zhang, X
author: Shinjo, SM
author: Rasheed, BA
author: Lin, JC
author: Carter, H
author: Jones, S
author: Keir, S
author: Parmigiani, G
author: Yan, H
author: McLendon, R
author: Olivi, A
author: Nikolsky, Y
author: Diaz Jr, LA
author: Tekleab, H
author: Vogelstein, B
author: Kinzler, KW
author: Velculescu, VE
author: Papadopoulos, N
author: Mankoo, P
author: Marie, SK
author: Parsons, DW
author: Busam, DA
author: Riggins, GJ
author: Bigner, DD
author: Karchin, R
author: Hartigan, J
author: Angenendt, P
author: Leary, RJ
author: Smith, DR
author: Strausberg, RL
author: Gallia, GL
author: Siu, IM
author: Nikolskaya, T
db: Pubmed
title: An integrated genomic analysis of human glioblastoma multiforme
source: Science 321:1807-12
year: 2008

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32874
data source: Provenance1
name: P32874
name: Acetyl-CoA carboxylase 2
name: ACC-beta
name: ACACB
name: Biotin carboxylase
xref: UnificationXref4791
feature: FragmentFeature877
cellular location: GO:0005829
comment: Reactome DB_ID: 3668800
display name: ACC2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q00955
data source: Provenance1
name: Q00955
name: Acetyl-CoA carboxylase 2
name: ACC-beta
name: ACACB
name: Biotin carboxylase
xref: UnificationXref4790
feature: FragmentFeature876
cellular location: GO:0005829
comment: Reactome DB_ID: 3668799
display name: ACC2

Homologues of ACACB
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4792
cellular location: GO:0005829
comment: Reactome DB_ID: 3668801
comment: Converted from EntitySet in Reactome

http://identifiers.org/pubmed/17035995
type: PublicationXref
id: 17035995
author: De Camilli, P
author: Di Paolo, G
db: Pubmed
title: Phosphoinositides in cell regulation and membrane dynamics
source: Nature 443:651-7
year: 2006

Glycine cleavage system L protein
type: Protein
entity reference: P09624
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Dihydrolipoamide dehydrogenase, mitochondrial
name: P09624
xref: UnificationXref4840
feature: FragmentFeature883
cellular location: GO:0005759
comment: Reactome DB_ID: 3666451
display name: DLD

P53157
type: Protein
entity reference: P53157
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: BRP44L
name: Mitochondrial pyruvate carrier 1
xref: UnificationXref4835
feature: FragmentFeature882
cellular location: GO:0005743
comment: Reactome DB_ID: 3670269
display name: MPC1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38857
data source: Provenance1
name: Mitochondrial pyruvate carrier 2
name: P38857
name: BRP44
xref: UnificationXref4832
feature: FragmentFeature881
cellular location: GO:0005743
comment: Reactome DB_ID: 3670277
display name: MPC2

http://identifiers.org/pubmed/8565070
type: PublicationXref
id: 8565070
author: Sentenac, A
author: Dieci, G
db: Pubmed
title: Facilitated recycling pathway for RNA polymerase III.
source: Cell 84:245-52
year: 1996

http://identifiers.org/pubmed/2040271
type: PublicationXref
id: 2040271
author: Sadahiro, S
author: Matsuda, T
author: Takenaka, M
author: Tanaka, T
author: Noguchi, T
author: Hirai, H
author: Imai, E
author: Yamada, K
db: Pubmed
title: Isolation and characterization of the human pyruvate kinase M gene
source: Eur J Biochem 198:101-6
year: 1991

Succinate Dehydrogenase complex subunit C
type: Protein
entity reference: Q04487
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Succinate dehydrogenase complex subunit C
name: Q04487
name: CYBL
name: QPS1
name: Succinate-ubiquinone oxidoreductase cytochrome B large subunit
name: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor
name: Integral membrane protein CII-3
name: QPs-1
xref: UnificationXref4909
feature: FragmentFeature897
cellular location: GO:0005743
comment: Reactome DB_ID: 3666415
display name: SDHC

Homologues of SDHC
type: Protein
data source: Provenance1
member physical entity: Succinate Dehydrogenase complex subunit C
member physical entity: P33421
xref: UnificationXref4912
cellular location: GO:0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3666420

Succinate dehydrogenase (ubiquinone) iron-sulfur protein, mitochondrial
type: Protein
entity reference: P21801
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SDHB
name: Succinate Dehydrogenase complex subunit B
name: P21801
name: Iron-sulfur subunit of complex II
xref: UnificationXref4906
feature: FragmentFeature896
cellular location: GO:0005743
comment: Reactome DB_ID: 3666410
display name: Ip

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P53598
data source: Provenance1
name: SUCLG1(28-333)
name: Succinyl-CoA synthetase, alpha-chain
xref: UnificationXref4896
feature: FragmentFeature895
cellular location: GO:0005759
comment: Reactome DB_ID: 3666428
display name: P53598

SDHA
type: Protein
entity reference: P47052
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Flavoprotein subunit of complex II
name: P47052
name: Succinate Dehydrogenase complex subunit A
name: Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial
xref: UnificationXref4916
feature: FragmentFeature900
cellular location: GO:0005743
comment: Reactome DB_ID: 3666404
display name: Fp

SDHA
type: Protein
entity reference: UniProt:Q00711
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Flavoprotein subunit of complex II
name: Succinate Dehydrogenase complex subunit A
name: Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial
name: Q00711
xref: UnificationXref4914
feature: FragmentFeature899
cellular location: GO:0005743
comment: Reactome DB_ID: 3666400
display name: Fp

Homologues of SDHA
type: Protein
data source: Provenance1
member physical entity: SDHA
xref: UnificationXref4917
cellular location: GO:0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3666405

P33421
type: Protein
entity reference: P33421
data source: Provenance1
name: Succinate Dehydrogenase complex subunit C
name: Note: the coordinates are copied over from Homo sapiens.
name: Succinate dehydrogenase complex subunit C
name: CYBL
name: QPS1
name: Succinate-ubiquinone oxidoreductase cytochrome B large subunit
name: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor
name: Integral membrane protein CII-3
name: QPs-1
xref: UnificationXref4911
feature: FragmentFeature898
cellular location: GO:0005743
comment: Reactome DB_ID: 3666419
display name: SDHC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P08417
data source: Provenance1
name: P08417
name: Fumarase
name: fumarate hydratase
name: Fumarate hydratase, mitochondrial
xref: UnificationXref4924
feature: FragmentFeature901
cellular location: GO:0005759
comment: Reactome DB_ID: 3666393
display name: FH

http://identifiers.org/pubmed/3356695
type: PublicationXref
id: 3356695
author: Panniers, R
author: Rowlands, AG
author: Henshaw, EC
db: Pubmed
title: The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2.
source: J Biol Chem 263:5526-33
year: 1988

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38703
data source: Provenance1
name: LAG1 homolog, ceramide synthase 5
name: P38703
name: LASS5
xref: UnificationXref4598
feature: FragmentFeature858
cellular location: GO:0005789
comment: Reactome DB_ID: 3670750
display name: CERS5

Homologues of CERS6
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4602
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670754

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P28496
data source: Provenance1
name: LASS4
name: LAG1 homolog, ceramide synthase 4
name: P28496
xref: UnificationXref4594
feature: FragmentFeature855
cellular location: GO:0005789
comment: Reactome DB_ID: 3670746
display name: CERS4

http://identifiers.org/pubmed/17402747
type: PublicationXref
id: 17402747
author: Magni, G
author: Franchetti, P
author: Cimadamore, F
author: Cappellacci, L
author: Orsomando, G
author: Scotti, S
author: Sorci, L
author: Petrelli, R
db: Pubmed
title: Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis
source: Biochemistry 46:4912-22
year: 2007

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38703
data source: Provenance1
name: LASS4
name: LAG1 homolog, ceramide synthase 4
name: P38703
xref: UnificationXref4595
feature: FragmentFeature856
cellular location: GO:0005789
comment: Reactome DB_ID: 3670747
display name: CERS4

Homologues of CERS5
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4599
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670751

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P28496
data source: Provenance1
name: LAG1 homolog, ceramide synthase 5
name: P28496
name: LASS5
xref: UnificationXref4597
feature: FragmentFeature857
cellular location: GO:0005789
comment: Reactome DB_ID: 3670749
display name: CERS5

Homologues of CERS3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4593
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670745

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P28496
data source: Provenance1
name: LASS3
name: LAG1 homolog, ceramide synthase 3
name: P28496
xref: UnificationXref4591
feature: FragmentFeature853
cellular location: GO:0005789
comment: Reactome DB_ID: 3670743
display name: CERS3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38703
data source: Provenance1
name: LASS3
name: LAG1 homolog, ceramide synthase 3
name: P38703
xref: UnificationXref4592
feature: FragmentFeature854
cellular location: GO:0005789
comment: Reactome DB_ID: 3670744
display name: CERS3

Homologues of CERS4
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4596
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670748

http://identifiers.org/pubmed/2069720
type: PublicationXref
id: 2069720
author: Myöhänen, S
author: Kauppinen, L
author: Jänne, J
author: Wahlfors, J
author: Alhonen, L
db: Pubmed
title: Human spermidine synthase gene: structure and chromosomal localization
source: DNA Cell Biol 10:467-74
year: 1991

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38703
data source: Provenance1
name: LAG1 homolog, ceramide synthase 2
name: LASS2
name: P38703
xref: UnificationXref4589
feature: FragmentFeature852
cellular location: GO:0005789
comment: Reactome DB_ID: 3670741
display name: CERS2

Homologues of CERS2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4590
cellular location: GO:0005789
comment: Reactome DB_ID: 3670742
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P28496
data source: Provenance1
name: LAG1 homolog, ceramide synthase 2
name: LASS2
name: P28496
xref: UnificationXref4587
feature: FragmentFeature851
cellular location: GO:0005789
comment: Reactome DB_ID: 3670737
display name: CERS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P40970
data source: Provenance1
name: PXLP-SPTLC2
name: P40970
name: serine palmitoyltransferase 2
xref: UnificationXref4573
feature: ModificationFeature142
feature: FragmentFeature849
cellular location: GO:0005789
comment: Reactome DB_ID: 3670726
display name: SPTLC2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P40970
data source: Provenance1
name: PXLP-SPTLC3
name: P40970
name: serine palmitoyltransferase 3
xref: UnificationXref4575
feature: FragmentFeature850
feature: ModificationFeature143
cellular location: GO:0005789
comment: Reactome DB_ID: 3670729
display name: SPTLC3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q05902
data source: Provenance1
name: GGT5 light chain
name: GGT5_HUMAN
name: GGT5(388-586)
name: Q05902
xref: UnificationXref4555
feature: FragmentFeature847
cellular location: GO:0005886
comment: Reactome DB_ID: 3670183
display name: GGTLA1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P25045
data source: Provenance1
name: P25045
name: serine palmitoyltransferase 1
xref: UnificationXref4571
feature: FragmentFeature848
cellular location: GO:0005789
comment: Reactome DB_ID: 3670721
display name: SPTLC1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q05902
data source: Provenance1
name: GGT1lc
name: GGT1_HUMAN
name: GGT1(381-569)
name: Q05902
name: Gamma-glutamyltranspeptidase 1
name: GGT1 light chain
xref: UnificationXref4552
feature: FragmentFeature845
cellular location: GO:0005886
comment: Reactome DB_ID: 3670179
display name: GGT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q05902
data source: Provenance1
name: GGT5_HUMAN
name: GGT5 heavy chain
name: GGT5(1-387)
name: GGTLA1
name: Q05902
xref: UnificationXref4554
feature: FragmentFeature846
cellular location: GO:0005886
comment: Reactome DB_ID: 3670182
display name: GGT5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q05902
data source: Provenance1
name: GGT1_HUMAN
name: GGT1hc
name: GGT1 heavy chain
name: Q05902
name: Gamma-glutamyltranspeptidase 1
name: GGT1(1-380)
xref: UnificationXref4551
feature: FragmentFeature844
cellular location: GO:0005886
comment: Reactome DB_ID: 3670180
display name: GGT1

http://identifiers.org/pubmed/17590538
type: PublicationXref
id: 17590538
author: Ball, E
author: Takeuchi, M
author: Harigai, M
author: Kamatani, N
author: Furuichi, K
author: Abe, J
author: Momohara, S
db: Pubmed
title: Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase
source: Gene 399:174-80
year: 2007

COQ5_YEAST
type: Protein
entity reference: UniProt:P49017 COQ5
data source: Provenance1
name: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial ecNumber2.1.1.201/ecNumber
name: COQ5
xref: UnificationXref4739
xref: UnificationXref4740
feature: FragmentFeature872
cellular location: GO:0005759
comment: Reactome DB_ID: 2167839
display name: Coq5

CAT5
type: Protein
entity reference: P41735
data source: Provenance1
name: Catabolite repression protein CAT5
name: CAT5_YEAST
xref: UnificationXref4749
xref: UnificationXref4750
feature: FragmentFeature873
cellular location: GO:0005743
comment: Reactome DB_ID: 2167845
display name: Cat5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P24583
data source: Provenance1
name: Protein kinase C, alpha type
name: P24583
name: PKC-A
name: PKC-alpha
xref: UnificationXref4767
feature: FragmentFeature874
cellular location: GO:0005829
comment: Reactome DB_ID: 3668633
display name: PRKCA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P24583
data source: Provenance1
name: Protein kinase C, alpha type
name: P24583
name: PKC-A
name: PKC-alpha
xref: UnificationXref4771
feature: FragmentFeature875
cellular location: GO:0005886
comment: Reactome DB_ID: 3668637
display name: PRKCA

Homologues of ENPP7
type: Protein
data source: Provenance1
member physical entity: P25353
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4664
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3672257

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P39997
data source: Provenance1
name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
name: P39997
name: ENPP7_HUMAN
xref: UnificationXref4661
feature: FragmentFeature867
cellular location: GO:0005886
comment: Reactome DB_ID: 3672255
display name: ENPP7

P25353
type: Protein
entity reference: P25353
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
name: ENPP7_HUMAN
xref: UnificationXref4663
feature: FragmentFeature868
cellular location: GO:0005886
comment: Reactome DB_ID: 3672256
display name: ENPP7

Para-hydroxybenzoate--polyprenyltransferase, mitochondrial
type: Protein
entity reference: N3419
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P32378
name: COQ2_HUMAN
xref: UnificationXref4680
feature: FragmentFeature869
cellular location: GO:0005743
comment: Reactome DB_ID: 3672779
display name: COQ2

COQ6_YEAST
type: Protein
entity reference: P53318
data source: Provenance1
name: Ubiquinone biosynthesis monooxygenase COQ6 ecNumber1.14.13.-/ecNumber
name: COQ6
xref: UnificationXref4696
xref: UnificationXref4697
feature: FragmentFeature870
cellular location: GO:0005743
comment: Reactome DB_ID: 2162276
display name: Coq6

COQ3_HUMAN
type: Protein
entity reference: P27680
data source: Provenance1
name: Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial ecNumber2.1.1.114/ecNumber
name: Note: the coordinates are copied over from Homo sapiens.
name: P27680
name: COQ3(?-369)
xref: UnificationXref4715
feature: FragmentFeature871
cellular location: GO:0005759
comment: Reactome DB_ID: 3672774
display name: COQ3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P23501
data source: Provenance1
name: sphingosine-1-phosphate phosphatase 2
name: P23501
xref: UnificationXref4617
feature: FragmentFeature864
cellular location: GO:0005789
comment: Reactome DB_ID: 3670774
display name: SGPP2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q05567
data source: Provenance1
name: Q05567
name: PXLP-SGPL1
name: sphingosine-1-phosphate lyase 1
xref: UnificationXref4626
feature: FragmentFeature865
feature: ModificationFeature144
cellular location: GO:0005789
comment: Reactome DB_ID: 3670783
display name: SGPL1

Homologues of SGPP2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4618
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670775

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P47013
data source: Provenance1
name: P47013
name: sphingosine-1-phosphate phosphatase 2
xref: UnificationXref4616
feature: FragmentFeature863
cellular location: GO:0005789
comment: Reactome DB_ID: 3670773
display name: SGPP2

CIT1
type: ProteinReference
name: YNR001C
name: LYS6
name: GLU3
name: UniProt:P00890 CIT1
name: N2019
xref: UnificationXref546
comment: CATALYTIC ACTIVITY Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA.PATHWAY Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.MISCELLANEOUS Citrate synthase is found in nearly all cells capable of oxidative metabolism.SIMILARITY Belongs to the citrate synthase family.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P40015
data source: Provenance1
name: P40015
name: NSMA_HUMAN
name: Sphingomyelin phosphodiesterase 2
xref: UnificationXref4656
feature: FragmentFeature866
cellular location: GO:0005886
comment: Reactome DB_ID: 3669356
display name: SMPD2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P28496
data source: Provenance1
name: P28496
name: LAG1 homolog, ceramide synthase 6
name: LASS6
xref: UnificationXref4600
feature: FragmentFeature859
cellular location: GO:0005789
comment: Reactome DB_ID: 3670752
display name: CERS6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P47013
data source: Provenance1
name: sphingosine-1-phosphate phosphatase 1
name: P47013
xref: UnificationXref4612
feature: FragmentFeature861
cellular location: GO:0005789
comment: Reactome DB_ID: 3670767
display name: SGPP1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P23501
data source: Provenance1
name: sphingosine-1-phosphate phosphatase 1
name: P23501
xref: UnificationXref4614
feature: FragmentFeature862
cellular location: GO:0005789
comment: Reactome DB_ID: 3670771
display name: SGPP1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38703
data source: Provenance1
name: LAG1 homolog, ceramide synthase 6
name: P38703
name: LASS6
xref: UnificationXref4601
feature: FragmentFeature860
cellular location: GO:0005789
comment: Reactome DB_ID: 3670753
display name: CERS6

Homologues of SGPP1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4615
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670772

UniProt:P28321
type: ProteinReference
xref: UnificationXref3296
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P22543
data source: Provenance1
name: PIK3C3
name: P22543
name: PI3K class III Catalytic subunit
xref: UnificationXref4328
feature: FragmentFeature824
cellular location: GO:0005829
comment: Reactome DB_ID: 3669141
display name: VPS34

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P22219
data source: Provenance1
name: P22219
name: PI3K class III regulatory subunit
name: PIK3R4(2-1358)
xref: UnificationXref4325
feature: FragmentFeature823
cellular location: GO:0005829
comment: Reactome DB_ID: 3669145
display name: PIK3R4

P32368
type: Protein
entity reference: UniProt:P32368
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: KIAA0851
xref: UnificationXref4318
feature: FragmentFeature822
cellular location: GO:0000139
comment: Reactome DB_ID: 3672406
display name: SACM1L

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P39104
data source: Provenance1
name: PIK4CB
name: P39104
xref: UnificationXref4312
feature: FragmentFeature821
cellular location: GO:0000139
comment: Reactome DB_ID: 3672370
display name: PI4KB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P39104
data source: Provenance1
name: PIK4CB
name: P39104
xref: UnificationXref4308
feature: FragmentFeature820
cellular location: GO:0005829
comment: Reactome DB_ID: 3672414
display name: PI4KB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P42951
data source: Provenance1
name: P42951
xref: UnificationXref4303
feature: FragmentFeature819
cellular location: GO:0005829
comment: Reactome DB_ID: 3672308
display name: PI4K2A

PI4KA/2A/2B
type: Protein
data source: Provenance1
member physical entity: Protein998
member physical entity: Protein999
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4304
cellular location: GO:0005829
comment: Reactome DB_ID: 3672426
comment: Converted from EntitySet in Reactome

P32368
type: Protein
entity reference: UniProt:P32368
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: KIAA0851
xref: UnificationXref4294
feature: FragmentFeature818
cellular location: GO:0005789
comment: Reactome DB_ID: 3672409
display name: SACM1L

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P34756
data source: Provenance1
name: 1-phosphatidylinositol-3-phosphate 5-kinase
name: PIKFYVE
name: FYV1_HUMAN
name: P34756
name: KIAA0981
xref: UnificationXref4339
feature: FragmentFeature825
cellular location: GO:0000139
comment: Reactome DB_ID: 3672379
display name: PIP5K3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P42837
data source: Provenance1
name: P42837
name: SAC3
name: Polyphosphoinositide phosphatase
name: FIG4_HUMAN
xref: UnificationXref4341
feature: FragmentFeature826
cellular location: GO:0000139
comment: Reactome DB_ID: 3672377
display name: FIG4

http://identifiers.org/pubmed/22798961
type: PublicationXref
id: 22798961
author: Wang, Xiaohong
author: Li, Ju-Pi
author: Chuang, Huai-Chia
author: Tan, Tse-Hua
db: Pubmed
title: Regulation of PKC-? function by phosphorylation in T cell receptor signaling
source: Front Immunol 3:197
year: 2012

http://identifiers.org/pubmed/19416660
type: PublicationXref
id: 19416660
author: Ren, M
author: Xu, Y
author: Malhotra, A
author: Schlame, M
db: Pubmed
title: Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species
source: Biochim Biophys Acta 1791:314-20
year: 2009

Q06708
type: Protein
entity reference: Q06708
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: VAC14
name: ArPIKfyve
name: TAX1BP2
name: VAC14_HUMAN
name: Protein VAC14 homolog
xref: UnificationXref4419
feature: FragmentFeature836
cellular location: late endosome membrane
comment: Reactome DB_ID: 3672363
display name: TRX

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P34756
data source: Provenance1
name: 1-phosphatidylinositol-3-phosphate 5-kinase
name: PIKFYVE
name: FYV1_HUMAN
name: P34756
name: KIAA0981
xref: UnificationXref4398
feature: FragmentFeature835
cellular location: early endosome membrane
comment: Reactome DB_ID: 3672417
display name: PIP5K3

PTGES3
type: Protein
entity reference: P28707
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Prostaglandin E synthase 3
name: P28707
xref: UnificationXref4506
feature: FragmentFeature840
cellular location: GO:0005829
comment: Reactome DB_ID: 3670156
display name: cPGES

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P47147
data source: Provenance1
name: P47147
xref: UnificationXref4429
feature: FragmentFeature839
cellular location: GO:0005829
comment: Reactome DB_ID: 3672316
display name: MTMR7

Regulation of APC/C activators between G1/S and early anaphase
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction67
evidence: Evidence131
xref: RelationshipXref83
xref: UnificationXref1325
xref: UnificationXref1324
pathway order: PathwayStep135
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P42837
data source: Provenance1
name: P42837
name: SAC3
name: Polyphosphoinositide phosphatase
name: FIG4_HUMAN
xref: UnificationXref4421
feature: FragmentFeature838
cellular location: late endosome membrane
comment: Reactome DB_ID: 3672355
display name: FIG4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P34756
data source: Provenance1
name: 1-phosphatidylinositol-3-phosphate 5-kinase
name: PIKFYVE
name: FYV1_HUMAN
name: P34756
name: KIAA0981
xref: UnificationXref4420
feature: FragmentFeature837
cellular location: late endosome membrane
comment: Reactome DB_ID: 3672359
display name: PIP5K3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P39109
data source: Provenance1
name: Multidrug resistance-associated protein 1
name: P39109
xref: UnificationXref4541
feature: FragmentFeature843
cellular location: GO:0005886
comment: Reactome DB_ID: 3670195
display name: ABCC1

P14772
type: Protein
entity reference: P14772
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Multidrug resistance-associated protein 1
xref: UnificationXref4539
feature: FragmentFeature842
cellular location: GO:0005886
comment: Reactome DB_ID: 3670191
display name: ABCC1

Homologues of ABCC1
type: Protein
data source: Provenance1
member physical entity: P14772
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4542
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670196

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q10740
data source: Provenance1
name: Leukotriene A-4 hydrolase-1
name: Q10740
name: LKHA4_HUMAN
xref: UnificationXref4529
feature: FragmentFeature841
cellular location: GO:0005829
comment: Reactome DB_ID: 3670202
display name: LTA4H

http://identifiers.org/pubmed/14660560
type: PublicationXref
id: 14660560
author: Yu, Y
author: Arnold, E
author: Shen, N
author: Ding, Jianping
author: Xu, X
author: Jin, Y
author: Xu, F
author: Jia, J
author: Liu, Y
db: Pubmed
title: Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity
source: J Biol Chem 279:8378-88
year: 2004

UniProt:P22219
type: ProteinReference
xref: UnificationXref4324
organism: BioSource1

http://identifiers.org/pubmed/15381398
type: PublicationXref
id: 15381398
author: Jaffe, EK
db: Pubmed
title: The porphobilinogen synthase catalyzed reaction mechanism
source: Bioorg Chem 32:316-25
year: 2004

http://identifiers.org/pubmed/14660569
type: PublicationXref
id: 14660569
author: Chaussade, C
author: Mandel, JL
author: Liaubet, L
author: Payrastre, B
author: Pendaries, C
author: Tronchère, H
author: Laporte, J
author: Pirola, L
db: Pubmed
title: Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells
source: J Biol Chem 279:7304-12
year: 2004

http://identifiers.org/pubmed/7913615
type: PublicationXref
id: 7913615
author: Sheng, H
author: Warner, TD
author: Murad, F
author: Mitchell, JA
db: Pubmed
title: Effects of cyclic GMP on smooth muscle relaxation
source: Adv Pharmacol 26:171-94
year: 1994

Q06708
type: Protein
entity reference: Q06708
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: VAC14
name: ArPIKfyve
name: TAX1BP2
name: VAC14_HUMAN
name: Protein VAC14 homolog
xref: UnificationXref4343
feature: FragmentFeature827
cellular location: GO:0000139
comment: Reactome DB_ID: 3672378
display name: TRX

Homologues of SYNJ2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4362
cellular location: GO:0005829
comment: Reactome DB_ID: 3672348
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q08227
data source: Provenance1
name: Q08227
xref: UnificationXref4352
feature: FragmentFeature828
cellular location: GO:0005829
comment: Reactome DB_ID: 3672329
display name: INPP5E

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q12271
data source: Provenance1
name: Q12271
name: KIAA0348
xref: UnificationXref4360
feature: FragmentFeature830
cellular location: GO:0005829
comment: Reactome DB_ID: 3672346
display name: SYNJ2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P40559
data source: Provenance1
name: P40559
name: KIAA0348
xref: UnificationXref4359
feature: FragmentFeature829
cellular location: GO:0005829
comment: Reactome DB_ID: 3672345
display name: SYNJ2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P47147
data source: Provenance1
name: P47147
xref: UnificationXref4371
feature: FragmentFeature832
cellular location: GO:0005829
comment: Reactome DB_ID: 3672392
display name: MTMR6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P50942
data source: Provenance1
name: P50942
name: KIAA0348
xref: UnificationXref4361
feature: FragmentFeature831
cellular location: GO:0005829
comment: Reactome DB_ID: 3672347
display name: SYNJ2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P42837
data source: Provenance1
name: P42837
name: SAC3
name: Polyphosphoinositide phosphatase
name: FIG4_HUMAN
xref: UnificationXref4396
feature: FragmentFeature833
cellular location: early endosome membrane
comment: Reactome DB_ID: 3672416
display name: FIG4

PI4K2A/2B
type: Protein
data source: Provenance1
member physical entity: Protein999
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4384
cellular location: GO:0005829
comment: Reactome DB_ID: 3672310
comment: Converted from EntitySet in Reactome

Q06708
type: Protein
entity reference: Q06708
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: VAC14
name: ArPIKfyve
name: TAX1BP2
name: VAC14_HUMAN
name: Protein VAC14 homolog
xref: UnificationXref4397
feature: FragmentFeature834
cellular location: early endosome membrane
comment: Reactome DB_ID: 3672418
display name: TRX

UniProt:P22203
type: ProteinReference
xref: UnificationXref1955
organism: BioSource1

UniProt:P00817
type: ProteinReference
xref: UnificationXref2260
organism: BioSource1

UniProt:P00812
type: ProteinReference
xref: UnificationXref6079
organism: BioSource1

http://identifiers.org/pubmed/7923172
type: PublicationXref
id: 7923172
author: Momparler, RL
author: Laliberte, J
db: Pubmed
title: Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA
source: Cancer Res 54:5401-7
year: 1994

http://identifiers.org/pubmed/20435355
type: PublicationXref
id: 20435355
author: Palczewski, Krzysztof
db: Pubmed
title: Retinoids for treatment of retinal diseases
source: Trends Pharmacol. Sci. 31:284-95
year: 2010

J2041
type: ProteinReference
name: ATP2
name: UniProt:P00830 ATP2
name: YJR121W
xref: UnificationXref540
comment: FUNCTION Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.CATALYTIC ACTIVITY ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).SUBUNIT F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.MISCELLANEOUS Present with 164000 molecules/cell in log phase SD medium.SIMILARITY Belongs to the ATPase alpha/beta chains family.
organism: BioSource1

http://identifiers.org/pubmed/20462400
type: PublicationXref
id: 20462400
author: Henley, Jeremy M
author: Wilkinson, Kevin A
db: Pubmed
title: Mechanisms, regulation and consequences of protein SUMOylation
source: Biochem. J. 428:133-45
year: 2010

http://identifiers.org/pubmed/8330740
type: PublicationXref
id: 8330740
author: Greider, CW
author: Collins, K
db: Pubmed
title: Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation
source: Genes Dev 7:1364-76
year: 1993

http://identifiers.org/pubmed/2542324
type: PublicationXref
id: 2542324
author: Kishi, F
author: Kajii, T
author: Sakurai, M
author: Matsuura, S
author: Fujii, H
author: Nakazawa, A
author: Yamada, M
author: Tanizawa, Y
author: Miwa, S
author: Igarashi, M
db: Pubmed
title: Human adenylate kinase deficiency associated with hemolytic anemia. A single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase.
source: J Biol Chem 264:10148-55
year: 1989

http://identifiers.org/pubmed/10648173
type: PublicationXref
id: 10648173
author: Menear, K
author: Baldock, D
author: Graff, P
author: Jones, CE
author: Akhlaq, M
author: Graham, B
db: Pubmed
title: Purification and characterization of human Syk produced using a baculovirus expression system
source: Protein Expr Purif 18:86-94
year: 2000

http://identifiers.org/pubmed/19261456
type: PublicationXref
id: 19261456
author: Procko, E
author: Gaudet, R
db: Pubmed
title: Antigen processing and presentation: TAPping into ABC transporters
source: Curr Opin Immunol 21:84-91
year: 2009

http://identifiers.org/pubmed/9949182
type: PublicationXref
id: 9949182
author: Pébusque, MJ
author: Grégoire, MJ
author: Zhang, B
author: Jonveaux, P
author: Popovici, C
author: Lafage-Pochitaloff, M
author: Birnbaum, D
db: Pubmed
title: The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
source: Blood 93:1381-9
year: 1999

http://identifiers.org/pubmed/4358634
type: PublicationXref
id: 4358634
author: Roth, DG
author: Deuel, TF
author: Shelton, E
db: Pubmed
title: Purification and properties of phosphoribosyl pyrophosphate synthetase from rat liver
source: J Biol Chem 249:291-296
year: 1974

http://identifiers.org/pubmed/9874197
type: PublicationXref
id: 9874197
author: Brees, C
author: Van Veldhoven, PP
author: Fransen, M
author: Baes, M
author: Wylin, T
author: Mannaerts, GP
db: Pubmed
title: Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii
source: Eur J Biochem 258:332-8
year: 1998

http://identifiers.org/pubmed/1439791
type: PublicationXref
id: 1439791
author: Cerione, RA
author: Witte, ON
author: Leonard, D
author: Maru, Y
author: Evans, T
author: Hart, MJ
db: Pubmed
title: A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs
source: Science 258:812-5
year: 1992

p53-Independent G1/S DNA damage checkpoint
type: Pathway
data source: Provenance1
pathway component: p53-Independent DNA Damage Response
evidence: Evidence74
xref: UnificationXref965
xref: UnificationXref964
pathway order: PathwayStep77
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/13679574
type: PublicationXref
id: 13679574
author: Bouvier, M
author: Rousseau, G
author: Angers, S
author: Charest, PG
author: Kohout, T
author: Azzi, M
author: Piñeyro, G
db: Pubmed
title: Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
source: Proc Natl Acad Sci U S A 100:11406-11
year: 2003

http://identifiers.org/pubmed/14988808
type: PublicationXref
id: 14988808
author: Jakobs, C
author: Huck, JH
author: Verhoeven, NM
author: van der Knaap, MS
author: Struys, EA
author: Salomons, GS
db: Pubmed
title: Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathy
source: Am J Hum Genet 74:745-51
year: 2004

http://identifiers.org/pubmed/1550217
type: PublicationXref
id: 1550217
author: Gould, GW
author: Bell, GI
author: Burant, CF
author: Davidson, NO
author: Ifkovits, CA
author: Hausman, AM
author: Buse, JB
db: Pubmed
title: Human intestinal glucose transporter expression and localization of GLUT5
source: Am J Physiol 262:C795-800
year: 1992

http://identifiers.org/pubmed/9883897
type: PublicationXref
id: 9883897
author: Csere, P
author: Lill, R
author: Kispal, G
db: Pubmed
title: Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p
source: FEBS Lett 441:266-70
year: 1998

RNA Polymerase I Transcription Initiation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction587
evidence: Evidence886
xref: UnificationXref6985
xref: RelationshipXref888
xref: UnificationXref6984
pathway order: PathwayStep890
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/9883880
type: PublicationXref
id: 9883880
author: Callebaut, I
author: Dehoux, P
author: Cossart, P
db: Pubmed
title: EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family
source: FEBS Lett 441:181-5
year: 1998

http://identifiers.org/pubmed/14530973
type: PublicationXref
id: 14530973
author: Mackenzie, B
author: Hediger, MA
db: Pubmed
title: SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1
source: Pflugers Arch 447:571-9
year: 2004

UniProt:P07560
type: ProteinReference
xref: UnificationXref1907
organism: BioSource1

SKI1
type: ProteinReference
name: G1645
name: YGL173C
name: KEM1
name: RAR5
name: UniProt:P22147 XRN1
name: SEP1
name: DST2
name: XRN1
xref: UnificationXref7580
comment: FUNCTION Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. The NMD pathway has a second role regulating the decay of wild-type mRNAs, and especially mRNAs that are important for telomere functions. Participate in CTH2-mediated and VTS1-mediated mRNA turnover. Involved in the degradation of several hypomodified mature tRNA species and participates in the 5'-processing or the degradation of the snoRNA precursors and rRNA processing. Involved in defense against virus and suppresses viral RNA recombination by rapidly removing the 5'-truncated RNAs, the substrates of recombination, and thus reducing the chance for recombination to occur in the parental strain. Required for the assembly of the virus-like particles of the Ty3 retrotransposon and contributes to the efficient generation of narnavirus 20S RNA by playing a major role in the elimination of the non-viral upstream sequences from the primary transcripts. Degrades single-stranded DNA (ss-DNA) and can renature complementary ss-DNA as well as catalyzes the formation of heteroduplex DNA from circular ss-DNA and homologous linear ds-DNA in vitro. Acts as a microtubule-associated protein which interacts with cytoplasmic microtubules through beta-tubulin and promotes in vitro assembly of tubulin into microtubules. Associates with microtubule functions such as chromosome transmission, nuclear migration, and SPB duplication. Has also a role in G1 to S transition and is involved in nuclear fusion during karyogamy. Required for the expression of ROK1 at the post-transcriptional level and for the alpha-factor induction of the karyogamy genes KAR3 and KAR4. Play…
organism: BioSource1

http://identifiers.org/pubmed/9331217
type: PublicationXref
id: 9331217
author: Cooper, JA
author: Hart, MC
author: Korshunova, YO
db: Pubmed
title: Vertebrates have conserved capping protein alpha isoforms with specific expression patterns
source: Cell Motil Cytoskeleton 38:120-32
year: 1997

ChEBI:26125 phytosterols
type: SmallMoleculeReference
name: phytosterols
xref: UnificationXref3259

UniProt:P22141
type: ProteinReference
xref: UnificationXref1110
organism: BioSource1

http://identifiers.org/pubmed/17222083
type: PublicationXref
id: 17222083
author: Lamarche-Vane, N
author: Tcherkezian, J
db: Pubmed
title: Current knowledge of the large RhoGAP family of proteins
source: Biol Cell 99:67-86
year: 2007

UniProt:P30771
type: ProteinReference
xref: UnificationXref7589
organism: BioSource1

UniProt:P30777
type: ProteinReference
xref: UnificationXref9478
organism: BioSource1

http://identifiers.org/pubmed/15665109
type: PublicationXref
id: 15665109
author: Dirago, L
author: Mifsud, S
author: Hyland, C
author: Alexander, WS
author: Hilton, DJ
author: Carpinelli, MR
author: Nicola, NA
author: Metcalf, D
db: Pubmed
title: Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene
source: Blood 105:3480-7
year: 2005

http://identifiers.org/pubmed/224930
type: PublicationXref
id: 224930
author: Inoue, K
author: Yamasawa, K
author: Nishimukai, H
db: Pubmed
title: Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes.
source: Biochim Biophys Acta 569:117-23
year: 1979

http://identifiers.org/pubmed/18436705
type: PublicationXref
id: 18436705
author: Scheuner, D
author: Kaufman, RJ
db: Pubmed
title: The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes
source: Endocr Rev 29:317-33
year: 2008

http://identifiers.org/pubmed/22108505
type: PublicationXref
id: 22108505
author: Basler, Konrad
author: Herr, Patrick
db: Pubmed
title: Porcupine-mediated lipidation is required for Wnt recognition by Wls
source: Dev. Biol. 361:392-402
year: 2012

http://identifiers.org/pubmed/8647822
type: PublicationXref
id: 8647822
author: Sanchez, HB
author: Osborne, TF
author: Rosenfeld, JM
author: Vallett, SM
db: Pubmed
title: A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene
source: J Biol Chem 271:12247-53
year: 1996

PublicationXref1058
type: PublicationXref
id: 978-0-444-53219-0
author: Smith, William L
author: Murphy, RC
db: ISBN
title: The eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase pathways
source: Biochemistry of Lipids, Lipoproteins and Membranes, 5th Edition (Book): 331-362
year: 2008

http://identifiers.org/pubmed/22983114
type: PublicationXref
id: 22983114
author: Boutros, Michael
author: Bartscherer, Kerstin
author: Chaudhary, Varun
author: Gross, Julia Christina
db: Pubmed
title: Active Wnt proteins are secreted on exosomes
source: Nat. Cell Biol. 14:1036-45
year: 2012

http://identifiers.org/pubmed/6693436
type: PublicationXref
id: 6693436
author: Hu, SZ
author: Wang, TS
author: Korn, D
db: Pubmed
title: DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha.
source: J Biol Chem 259:1854-65
year: 1984

http://identifiers.org/pubmed/12800216
type: PublicationXref
id: 12800216
author: Zhang, M
author: Zhu, F
db: Pubmed
title: DNA polymerase zeta: new insight into eukaryotic mutagenesis and mammalian embryonic development.
source: World J Gastroenterol 9:1165-9
year: 2003

UniProt:Q00578
type: ProteinReference
xref: UnificationXref2295
organism: BioSource1

UniProt:P20048
type: ProteinReference
xref: UnificationXref9491
organism: BioSource1

http://identifiers.org/pubmed/2408761
type: PublicationXref
id: 2408761
author: Sharp, PA
author: Moore, CL
db: Pubmed
title: Accurate cleavage and polyadenylation of exogenous RNA substrate.
source: Cell 41:845-55
year: 1985

ChEBI:28477 7alpha,12alpha-dihydroxycholest-4-en-3-one
type: SmallMoleculeReference
name: 7alpha,12alpha-dihydroxycholest-4-en-3-one
xref: UnificationXref3834

http://identifiers.org/pubmed/3893466
type: PublicationXref
id: 3893466
author: Jornvall, H
db: Pubmed
title: Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes
source: Alcohol 2:61-6
year: 1985

Diphosphatidylglycerol
type: SmallMoleculeReference
name: cardiolipin
name: cardiolipin [ChEBI:28494]
name: cardiolipins
name: 1',3'-Bis(1,2-diacyl-sn-glycero-3-phospho)-sn-glycerol
xref: UnificationXref4254

Homologues of NMNAT2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5665
cellular location: GO:0000139
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3669611

http://identifiers.org/pubmed/8662720
type: PublicationXref
id: 8662720
author: Korenberg, J
author: Garrow, TA
author: Qi, H
author: Choi, YJ
author: Shane, B
author: Chen, L
db: Pubmed
title: Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
source: J Biol Chem 271:13077-87
year: 1996

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q06178
data source: Provenance1
name: Nicotinamide mononucleotide adenylyltransferase 1
name: Q06178
xref: UnificationXref5656
feature: FragmentFeature977
cellular location: GO:0005654
comment: Reactome DB_ID: 3669750
display name: NMNAT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P53204
data source: Provenance1
name: P53204
name: Nicotinamide mononucleotide adenylyltransferase 1
xref: UnificationXref5654
feature: FragmentFeature976
cellular location: GO:0005654
comment: Reactome DB_ID: 3669749
display name: NMNAT1

Homologues of NMNAT1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5657
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3669751

http://identifiers.org/pubmed/7890675
type: PublicationXref
id: 7890675
author: Haucke, V
author: Schatz, G
author: Hahne, K
author: Lithgow, T
author: Rospert, S
db: Pubmed
title: The yeast mitochondrial protein import receptor Mas20p binds precursor proteins through electrostatic interaction with the positively charged presequence
source: J Biol Chem 270:5565-70
year: 1995

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P43619
data source: Provenance1
name: Nicotinate-nucleotide pyrophosphorylase (carboxylating)
name: P43619
xref: UnificationXref5643
feature: FragmentFeature975
cellular location: GO:0005829
comment: Reactome DB_ID: 3669618
display name: QPRT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32874
data source: Provenance1
name: Btn-ACACB
name: P32874
name: Acetyl-CoA carboxylase 2
name: ACC-beta
name: Biotin carboxylase
xref: UnificationXref5628
feature: ModificationFeature151
feature: FragmentFeature974
cellular location: GO:0005829
comment: Reactome DB_ID: 3673005
display name: ACC2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q00955
data source: Provenance1
name: Q00955
name: Btn-ACACB
name: Acetyl-CoA carboxylase 2
name: ACC-beta
name: Biotin carboxylase
xref: UnificationXref5627
feature: FragmentFeature973
feature: ModificationFeature150
cellular location: GO:0005829
comment: Reactome DB_ID: 3673003
display name: ACC2

Homologues of Btn-ACACB
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5629
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3673006

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32874
data source: Provenance1
name: ACACA_HUMAN
name: ACACA
name: P32874
name: Acetyl-CoA carboxylase 1
xref: UnificationXref5622
feature: FragmentFeature972
cellular location: GO:0005829
comment: Reactome DB_ID: 3672997
display name: ACC1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q00955
data source: Provenance1
name: Q00955
name: ACACA_HUMAN
name: ACACA
name: Acetyl-CoA carboxylase 1
xref: UnificationXref5621
feature: FragmentFeature971
cellular location: GO:0005829
comment: Reactome DB_ID: 3672996
display name: ACC1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P32327
data source: Provenance1
name: P32327
name: Pyruvic carboxylase
name: Pyruvate carboxylase, mitochondrial precursor
name: pyruvate carboxylase
xref: UnificationXref5603
feature: FragmentFeature964
cellular location: GO:0005829
comment: Reactome DB_ID: 3672980
display name: PC

http://identifiers.org/pubmed/15585605
type: PublicationXref
id: 15585605
author: Takeda, K
author: Akira, S
db: Pubmed
title: TIRAP/Mal, TRIF and TRAM. Differential utilization of these TIR
source: Int Immunol 17:1-14
year: 2005

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P11154
data source: Provenance1
name: P11154
name: Pyruvic carboxylase
name: Pyruvate carboxylase, mitochondrial precursor
name: pyruvate carboxylase
xref: UnificationXref5604
feature: FragmentFeature965
cellular location: GO:0005829
comment: Reactome DB_ID: 3672981
display name: PC

Homologues of Btn-PC
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5609
cellular location: GO:0005829
comment: Reactome DB_ID: 3672988
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P32327
data source: Provenance1
name: P32327
name: Pyruvic carboxylase
name: Pyruvate carboxylase, mitochondrial precursor
name: pyruvate carboxylase
xref: UnificationXref5607
feature: FragmentFeature966
feature: ModificationFeature148
cellular location: GO:0005829
comment: Reactome DB_ID: 3672985
display name: Btn-PC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P11154
data source: Provenance1
name: P11154
name: Pyruvic carboxylase
name: Pyruvate carboxylase, mitochondrial precursor
name: pyruvate carboxylase
xref: UnificationXref5608
feature: ModificationFeature149
feature: FragmentFeature967
cellular location: GO:0005829
comment: Reactome DB_ID: 3672987
display name: Btn-PC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P48445
data source: Provenance1
name: P48445
name: BPL1_HUMAN
name: Biotin--protein ligase ecNumber6.3.4.-/ecNumber
xref: UnificationXref5612
feature: FragmentFeature968
cellular location: GO:0005829
comment: Reactome DB_ID: 3672993
display name: HLCS

Homologues of Btn-PC
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5617
cellular location: GO:0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3673028

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P32327
data source: Provenance1
name: P32327
name: Pyruvic carboxylase
name: Pyruvate carboxylase, mitochondrial precursor
name: pyruvate carboxylase
xref: UnificationXref5615
feature: FragmentFeature969
feature: ModificationFeature148
cellular location: GO:0005759
comment: Reactome DB_ID: 3673026
display name: Btn-PC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P11154
data source: Provenance1
name: P11154
name: Pyruvic carboxylase
name: Pyruvate carboxylase, mitochondrial precursor
name: pyruvate carboxylase
xref: UnificationXref5616
feature: FragmentFeature970
feature: ModificationFeature149
cellular location: GO:0005759
comment: Reactome DB_ID: 3673027
display name: Btn-PC

Homologues of ACACA
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5623
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3672998

UniProt:Q05027
type: ProteinReference
xref: UnificationXref7149
organism: BioSource1

Homologues of PPCDC
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5542
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3669574

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P36076
data source: Provenance1
name: Phosphopantothenoylcysteine decarboxylase
name: P36076
name: COAC_HUMAN
xref: UnificationXref5537
feature: FragmentFeature957
cellular location: GO:0005829
comment: Reactome DB_ID: 3669565
display name: PPCDC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38702
data source: Provenance1
name: Grave disease autoantigen
name: SLC25A16
xref: UnificationXref5547
feature: FragmentFeature960
cellular location: GO:0005743
comment: Reactome DB_ID: 3669670
display name: P38702

Homologues of PDXK
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5561
cellular location: GO:0005829
comment: Reactome DB_ID: 3671778
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q08438
data source: Provenance1
name: Phosphopantothenoylcysteine decarboxylase
name: Q08438
name: COAC_HUMAN
xref: UnificationXref5539
feature: FragmentFeature958
cellular location: GO:0005829
comment: Reactome DB_ID: 3669569
display name: PPCDC

http://identifiers.org/pubmed/15031527
type: PublicationXref
id: 15031527
author: Matsumoto, M
author: Seya, T
author: Funami, K
author: Oshiumi, H
db: Pubmed
title: Toll-like receptor 3: a link between toll-like receptor, interferon and viruses
source: Microbiol Immunol 48:147-54
year: 2004

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P36024
data source: Provenance1
name: Phosphopantothenoylcysteine decarboxylase
name: COAC_HUMAN
name: P36024
xref: UnificationXref5541
feature: FragmentFeature959
cellular location: GO:0005829
comment: Reactome DB_ID: 3669573
display name: PPCDC

PNPO(1-216)
type: Protein
entity reference: P38075
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Pyridoxine-5'-phosphate oxidase
name: P38075
xref: UnificationXref5584
feature: FragmentFeature963
cellular location: GO:0005829
comment: Reactome DB_ID: 3671787
display name: PNPO

Homologues of PC
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5605
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3672982

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P53727
data source: Provenance1
name: P53727
name: Pyridoxal kinase
xref: UnificationXref5558
feature: FragmentFeature961
cellular location: GO:0005829
comment: Reactome DB_ID: 3671773
display name: PDXK

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P39988
data source: Provenance1
name: P39988
name: Pyridoxal kinase
xref: UnificationXref5560
feature: FragmentFeature962
cellular location: GO:0005829
comment: Reactome DB_ID: 3671777
display name: PDXK

http://identifiers.org/pubmed/19489725
type: PublicationXref
id: 19489725
author: Joazeiro, CA
author: Deshaies, RJ
db: Pubmed
title: RING domain E3 ubiquitin ligases
source: Annu Rev Biochem 78:399-434
year: 2009

http://identifiers.org/pubmed/8618861
type: PublicationXref
id: 8618861
author: Nevins, JR
author: DeGregori, J
author: Ohtani, K
db: Pubmed
title: Regulation of the cyclin E gene by transcription factor E2F1
source: Proc Natl Acad Sci U S A 92:12146-50
year: 1995

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P47119
data source: Provenance1
name: P47119
name: Inosine triphosphate pyrophosphatase
xref: UnificationXref5442
feature: FragmentFeature949
cellular location: GO:0005829
comment: Reactome DB_ID: 3672857
display name: ITPA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q01976
data source: Provenance1
name: Nudix motif 5
name: ADP-sugar pyrophosphatase
name: Q01976
xref: UnificationXref5466
feature: FragmentFeature950
cellular location: GO:0005829
comment: Reactome DB_ID: 3672799
display name: NUDT5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P35202
data source: Provenance1
name: P35202
name: TPK1_HUMAN
name: Thiamin pyrophosphokinase 1
xref: UnificationXref5491
feature: FragmentFeature951
cellular location: GO:0005829
comment: Reactome DB_ID: 3669558
display name: TPK1

Riboflavin kinase
type: Protein
entity reference: Q03778
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q03778
name: RIFK_HUMAN
name: RFK(1-162)
xref: UnificationXref5503
feature: FragmentFeature952
cellular location: GO:0005829
comment: Reactome DB_ID: 3669599
display name: RFK

glutathione reductase
type: Protein
entity reference: P41921
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: GSR isoform 2
name: GSR-2
name: P41921
name: GRase
name: GSHR_HUMAN
name: Glutathione reductase, mitochondrial precursor
xref: UnificationXref5432
feature: FragmentFeature948
cellular location: GO:0005829
comment: Reactome DB_ID: 3666707
display name: GR

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P40506
data source: Provenance1
name: COAB
name: P40506
name: PPCS_HUMAN
name: Phosphopantothenate-cysteine ligase
xref: UnificationXref5529
feature: FragmentFeature956
cellular location: GO:0005829
comment: Reactome DB_ID: 3669551
display name: PPCS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q03219
data source: Provenance1
name: Q8NFF5_HUMAN
name: Q03219
name: FAD1 flavin adenine dinucleotide synthetase homolog
xref: UnificationXref5508
feature: FragmentFeature953
cellular location: GO:0005829
comment: Reactome DB_ID: 3669581
display name: FLAD1

Homologues of ENPP1
type: Protein
data source: Provenance1
member physical entity: P25353
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5513
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3669592

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P39997
data source: Provenance1
name: Ectonucleotide pyrophosphatase/phosphodiesterase 1
name: P39997
name: NPP1_HUMAN
xref: UnificationXref5511
feature: FragmentFeature954
cellular location: GO:0005886
comment: Reactome DB_ID: 3669587
display name: ENPP1

P25353
type: Protein
entity reference: P25353
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Ectonucleotide pyrophosphatase/phosphodiesterase 1
name: NPP1_HUMAN
xref: UnificationXref5512
feature: FragmentFeature955
cellular location: GO:0005886
comment: Reactome DB_ID: 3669591
display name: ENPP1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P15454
data source: Provenance1
name: Guanylate kinase (EC 2.7.4.8) (GMP kinase)
name: GMP kinase
name: P15454
name: guanylate kinase 1
xref: UnificationXref5389
feature: FragmentFeature942
cellular location: GO:0005829
comment: Reactome DB_ID: 3667655
display name: GUK1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P00572
data source: Provenance1
name: dTMP kinase
name: deoxythymidylate kinase (thymidylate kinase)
name: Thymidylate kinase
name: DTYMK(2-212)
xref: UnificationXref5405
feature: FragmentFeature943
cellular location: GO:0005829
comment: Reactome DB_ID: 3667562
display name: P00572

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P07170
data source: Provenance1
name: Adenylate kinase isoenzyme 2, mitochondrial
name: adenylate kinase 2
name: ATP-AMP transphosphorylase
name: Adenylate kinase isoenzyme 2, mitochondrial (EC 2.7.4.3) (ATP-AMP transphosphorylase)
name: P07170
xref: UnificationXref5357
feature: FragmentFeature940
cellular location: GO:0005758
comment: Reactome DB_ID: 3668426
display name: AK2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P15700
data source: Provenance1
name: Adenylate kinase isoenzyme 5 (EC 2.7.4.3) (ATP-AMP transphosphorylase)
name: Adenylate kinase isoenzyme 5
name: adenylate kinase 5
name: ATP-AMP transphosphorylase
name: P15700
xref: UnificationXref5372
feature: FragmentFeature941
cellular location: GO:0005829
comment: Reactome DB_ID: 3668417
display name: AK5

http://identifiers.org/pubmed/1756912
type: PublicationXref
id: 1756912
author: Morgan, R
author: Rees, A
author: Choi, WH
author: Moller, DE
author: O'Rahilly, S
author: Buse, JB
author: Flier, JS
db: Pubmed
title: Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects
source: Diabetes 40:1712-8
year: 1991

http://identifiers.org/pubmed/9461603
type: PublicationXref
id: 9461603
author: Aguado, B
author: Campbell, RD
db: Pubmed
title: Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex
source: J Biol Chem 273:4096-105
year: 1998

Assembly of the RAD51-ssDNA nucleoprotein complex
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction767
pathway component: BiochemicalReaction766
evidence: Evidence1246
xref: UnificationXref8945
xref: UnificationXref8944
xref: RelationshipXref1084
pathway order: PathwayStep1251
pathway order: PathwayStep1250
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

CTP synthase 2
type: Protein
entity reference: UniProt:P28274
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P28274
xref: UnificationXref5419
feature: FragmentFeature946
cellular location: GO:0005829
comment: Reactome DB_ID: 3671269
display name: CTPS2

CTP synthase 2
type: Protein
entity reference: UniProt:P38627
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P38627
xref: UnificationXref5420
feature: FragmentFeature947
cellular location: GO:0005829
comment: Reactome DB_ID: 3671270
display name: CTPS2

UTP--ammonia ligase
type: Protein
entity reference: UniProt:P38627
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: CTP synthase
name: P38627
name: CTP synthetase
xref: UnificationXref5414
feature: FragmentFeature945
cellular location: GO:0005829
comment: Reactome DB_ID: 3667573
display name: CTPS1

Homologues of CTPS2
type: Protein
data source: Provenance1
member physical entity: CTP synthase 2
xref: UnificationXref5421
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3671271

Homologues of CTPS1
type: Protein
data source: Provenance1
member physical entity: UTP--ammonia ligase
xref: UnificationXref5415
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3667574

UTP--ammonia ligase
type: Protein
entity reference: UniProt:P28274
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P28274
name: CTP synthase
name: CTP synthetase
xref: UnificationXref5412
feature: FragmentFeature944
cellular location: GO:0005829
comment: Reactome DB_ID: 3667569
display name: CTPS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P06785
data source: Provenance1
name: TYMS
name: TSase
name: P06785
name: Thymidylate synthase
xref: UnificationXref5313
feature: FragmentFeature937
cellular location: GO:0005829
comment: Reactome DB_ID: 3667548
display name: TS

P33317
type: Protein
entity reference: P33317
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: deoxyuridine triphosphatase isoform 2
name: dUTP pyrophosphatase
xref: UnificationXref5303
feature: FragmentFeature936
cellular location: GO:0005654
comment: Reactome DB_ID: 3667581
display name: DUT-2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P06773
data source: Provenance1
name: Deoxycytidylate deaminase
name: P06773
name: dCMP deaminase
xref: UnificationXref5293
feature: FragmentFeature935
cellular location: GO:0005829
comment: Reactome DB_ID: 3667541
display name: DCTD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P03962
data source: Provenance1
name: Orotate phosphoribosyltransferase
name: UMPS(2-480)
name: P03962
name: OMPdecase
name: OPRtase
name: UMP synthase
name: uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)
name: Uridine 5'-monophosphate synthase
name: Uridine 5'-monophosphate synthase (UMP synthase) (Includes: Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRtase); Orotidine 5'- phosphate decarboxylase (EC 4.1.1.23) (OMPdecase))
name: Orotidine 5'- phosphate decarboxylase
xref: UnificationXref5277
feature: FragmentFeature934
cellular location: GO:0005829
comment: Reactome DB_ID: 3667497
display name: UMPS

Myokinase
type: Protein
entity reference: P15700
data source: Provenance1
name: adenylate kinase 1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP-AMP transphosphorylase
name: Adenylate kinase isoenzyme 1
name: P15700
name: Adenylate kinase isoenzyme 1 (EC 2.7.4.3) (ATP-AMP transphosphorylase) (AK1) (Myokinase)
xref: UnificationXref5350
feature: FragmentFeature939
cellular location: GO:0005829
comment: Reactome DB_ID: 3667872
display name: AK1

Adenylate Kinase
type: Protein
data source: Provenance1
member physical entity: Myokinase
xref: UnificationXref5351
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3667873

Toll Like Receptor 9 (TLR9) Cascade
type: Pathway
data source: Provenance1
pathway component: REACT 103436.9
evidence: Evidence1316
xref: RelationshipXref1117
xref: UnificationXref9192
xref: UnificationXref9191
pathway order: PathwayStep1318
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q06549
data source: Provenance1
name: Q06549
name: Cytidine deaminase
name: Cytidine aminohydrolase
xref: UnificationXref5336
feature: FragmentFeature938
cellular location: GO:0005829
comment: Reactome DB_ID: 3667555
display name: CDA

Dihydroorotate oxidase
type: Protein
entity reference: UniProt:P28272
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Dihydroorotate dehydrogenase, mitochondrial precursor
name: P28272
name: DHOdehase
name: dihydroorotate dehydrogenase
name: Dihydroorotate dehydrogenase, mitochondrial precursor (EC 1.3.3.1) (Dihydroorotate oxidase) (DHOdehase) (Fragment)
xref: UnificationXref5266
feature: FragmentFeature933
cellular location: GO:0005743
comment: Reactome DB_ID: 3667506
display name: DHODH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P07259
data source: Provenance1
name: Aspartate carbamoyltransferase
name: P07259
name: Dihydroorotase
name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
name: CAD protein (Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3))
name: Glutamine-dependent carbamoyl-phosphate synthase
xref: UnificationXref5248
feature: FragmentFeature932
cellular location: GO:0005829
comment: Reactome DB_ID: 3667513
display name: CAD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P06115
data source: Provenance1
name: P06115
name: Catalase apoprotein (EC 1.11.1.6)
name: Catalase
name: CATA_HUMAN
xref: UnificationXref5234
feature: FragmentFeature931
cellular location: GO:0005782
comment: Reactome DB_ID: 3668202
display name: CAT

G1/S-Specific Transcription
type: Pathway
data source: Provenance1
pathway component: TemplateReaction2
evidence: Evidence81
xref: UnificationXref996
xref: UnificationXref995
xref: RelationshipXref59
pathway order: PathwayStep84
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Q05788
type: Protein
entity reference: UniProt:Q05788
data source: Provenance1
xref: UnificationXref5177
cellular location: GO:0005829
comment: Reactome DB_ID: 3667879

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P38150
data source: Provenance1
name: AMP deaminase 3
name: Erythrocyte AMP deaminase
name: AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase)
name: AMP deaminase isoform E
name: P38150
name: erythrocyte AMP deaminase
xref: UnificationXref5151
feature: FragmentFeature926
cellular location: GO:0005829
comment: Reactome DB_ID: 3668225
display name: AMPD3

Adenine phosphoribosyltransferase
type: Protein
entity reference: UniProt:P36973
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P36973
xref: UnificationXref5198
feature: FragmentFeature927
cellular location: GO:0005829
comment: Reactome DB_ID: 3667860
display name: APRT

Homologues of APRT
type: Protein
data source: Provenance1
member physical entity: Adenine phosphoribosyltransferase
xref: UnificationXref5201
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3667865

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q07729
data source: Provenance1
name: GAH
name: Guanase
name: Guanine deaminase
name: Q07729
name: p51-nedasin
name: Guanine aminohydrolase
name: Guanine aminase
xref: UnificationXref5217
feature: FragmentFeature929
cellular location: GO:0005829
comment: Reactome DB_ID: 3667887
display name: GDA

Adenine phosphoribosyltransferase
type: Protein
entity reference: P49435
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P49435
xref: UnificationXref5200
feature: FragmentFeature928
cellular location: GO:0005829
comment: Reactome DB_ID: 3667864
display name: APRT

UniProt:P28239
type: ProteinReference
xref: UnificationXref2262
organism: BioSource1

P15202
type: Protein
entity reference: P15202
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Catalase apoprotein (EC 1.11.1.6)
name: Catalase
name: CATA_HUMAN
xref: UnificationXref5232
feature: FragmentFeature930
cellular location: GO:0005782
comment: Reactome DB_ID: 3668198
display name: CAT

Homologues of CAT
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P15202
xref: UnificationXref5235
cellular location: GO:0005782
comment: Reactome DB_ID: 3668203
comment: Converted from EntitySet in Reactome

http://identifiers.org/pubmed/18043707
type: PublicationXref
id: 18043707
author: Hamm, HE
author: Oldham, WM
db: Pubmed
title: Heterotrimeric G protein activation by G-protein-coupled receptors
source: Nat Rev Mol Cell Biol 9:60-71
year: 2008

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P40361
data source: Provenance1
name: P40361
name: AMP deaminase 3
name: Erythrocyte AMP deaminase
name: AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase)
name: AMP deaminase isoform E
name: erythrocyte AMP deaminase
xref: UnificationXref5150
feature: FragmentFeature925
cellular location: GO:0005829
comment: Reactome DB_ID: 3668224
display name: AMPD3

Homologues of AMPD3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5152
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3668226

http://identifiers.org/pubmed/8755573
type: PublicationXref
id: 8755573
author: Webster, MK
author: Meyer, AN
author: Donoghue, DJ
author: Hart, KC
author: Galvin, BD
db: Pubmed
title: Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras
source: Proc Natl Acad Sci U S A 93:7894-9
year: 1996

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P40361
data source: Provenance1
name: AMP deaminase isoform L
name: P40361
name: AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L)
name: AMP deaminase 2
xref: UnificationXref5146
feature: FragmentFeature923
cellular location: GO:0005829
comment: Reactome DB_ID: 3668220
display name: AMPD2

Homologues of AMPD2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5148
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3668222

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P38150
data source: Provenance1
name: AMP deaminase 1 (EC 3.5.4.6) (Myoadenylate deaminase) (AMP deaminase isoform M)
name: Myoadenylate deaminase
name: AMP deaminase isoform M
name: myoadenylate deaminase
name: AMP deaminase 1
name: P38150
xref: UnificationXref5143
feature: FragmentFeature922
cellular location: GO:0005829
comment: Reactome DB_ID: 3668217
display name: AMPD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P40361
data source: Provenance1
name: AMP deaminase 1 (EC 3.5.4.6) (Myoadenylate deaminase) (AMP deaminase isoform M)
name: Myoadenylate deaminase
name: AMP deaminase isoform M
name: P40361
name: myoadenylate deaminase
name: AMP deaminase 1
xref: UnificationXref5141
feature: FragmentFeature921
cellular location: GO:0005829
comment: Reactome DB_ID: 3668213
display name: AMPD1

Homologues of AMPD1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5144
cellular location: GO:0005829
comment: Reactome DB_ID: 3668218
comment: Converted from EntitySet in Reactome

P47143
type: Protein
entity reference: P47143
data source: Provenance1
name: Adenosine kinase
name: Note: the coordinates are copied over from Homo sapiens.
name: ADK(2-362)
name: Adenosine 5'-phosphotransferase
xref: UnificationXref5136
feature: FragmentFeature920
cellular location: GO:0005829
comment: Reactome DB_ID: 3668322
display name: AK

IMP--aspartate ligase 2
type: Protein
entity reference: P80210
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenylosuccinate synthetase (EC 6.3.4.4) (IMP--aspartate ligase) (AdSS) (AMPSase)
name: ADSS(2-456)
name: AMPSase 2
name: Adenylosuccinate synthetase 2
name: adenylosuccinate synthetase
name: P80210
xref: UnificationXref5111
feature: FragmentFeature919
cellular location: GO:0005829
comment: Reactome DB_ID: 3668513
display name: AdSS 2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P80210
data source: Provenance1
name: IMP--aspartate ligase 1
name: AMPSase 1
name: Adenylosuccinate synthetase isozyme 1
name: AdSS 1
name: adenylosuccinate synthetase 1
name: P80210
name: adenylosuccinate synthetase like 1
xref: UnificationXref5108
feature: FragmentFeature918
cellular location: GO:0005829
comment: Reactome DB_ID: 3668510
display name: ADSSL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38625
data source: Provenance1
name: guanine monophosphate synthetase
name: Glutamine amidotransferase
name: GMP synthetase
name: P38625
name: GMP synthase (glutamine-hydrolyzing)
xref: UnificationXref5101
feature: FragmentFeature917
cellular location: GO:0005829
comment: Reactome DB_ID: 3667661
display name: GMPS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P38150
data source: Provenance1
name: AMP deaminase isoform L
name: AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L)
name: AMP deaminase 2
name: P38150
xref: UnificationXref5147
feature: FragmentFeature924
cellular location: GO:0005829
comment: Reactome DB_ID: 3668221
display name: AMPD2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P50094
data source: Provenance1
name: IMP (inosine monophosphate) dehydrogenase 1
name: Inosine-5'-monophosphate dehydrogenase 1 (EC 1.1.1.205) (IMP dehydrogenase 1) (IMPDH-I) (IMPD 1)
name: IMP dehydrogenase 1
name: P50094
name: IMPDH-I
name: Inosine-5'-monophosphate dehydrogenase 1
name: IMPD 1
xref: UnificationXref5086
feature: FragmentFeature912
cellular location: GO:0005829
comment: Reactome DB_ID: 3667667
display name: IMPDH1

Homologues of IMPDH1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5095
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3667684

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P50095
data source: Provenance1
name: IMP (inosine monophosphate) dehydrogenase 1
name: Inosine-5'-monophosphate dehydrogenase 1 (EC 1.1.1.205) (IMP dehydrogenase 1) (IMPDH-I) (IMPD 1)
name: IMP dehydrogenase 1
name: P50095
name: IMPDH-I
name: Inosine-5'-monophosphate dehydrogenase 1
name: IMPD 1
xref: UnificationXref5090
feature: FragmentFeature914
cellular location: GO:0005829
comment: Reactome DB_ID: 3667675
display name: IMPDH1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O42831
data source: Provenance1
name: IMP (inosine monophosphate) dehydrogenase 1
name: Inosine-5'-monophosphate dehydrogenase 1 (EC 1.1.1.205) (IMP dehydrogenase 1) (IMPDH-I) (IMPD 1)
name: IMP dehydrogenase 1
name: O42831
name: IMPDH-I
name: Inosine-5'-monophosphate dehydrogenase 1
name: IMPD 1
xref: UnificationXref5088
feature: FragmentFeature913
cellular location: GO:0005829
comment: Reactome DB_ID: 3667671
display name: IMPDH1

UniProt:P22139 RPB10
type: ProteinReference
name: YOR210W
name: RPB10
xref: UnificationXref2305
comment: FUNCTION DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft.SUBUNIT Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of 14, 12 and 17 subunits, respectively.MISCELLANEOUS Present with 5300 molecules/cell in log phase SD medium.SIMILARITY Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.
organism: BioSource1

Homologues of ATIC
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5076
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3667697

SYGP-ORF23
type: ProteinReference
name: YEL032W
name: UniProt:P24279 MCM3
name: MCM3
xref: UnificationXref247
comment: FUNCTION Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity. Necessary for cell growth.CATALYTIC ACTIVITY ATP + H(2)O = ADP + phosphate.SUBUNIT Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5; loaded onto DNA, forms a head-head double hexamer. Interacts with CSM1.MISCELLANEOUS Present with 35100 molecules/cell in log phase SD medium.MISCELLANEOUS Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex.SIMILARITY Belongs to the MCM family.SIMILARITY Contains 1 MCM domain.
organism: BioSource1

ASASE
type: Protein
entity reference: Q05911
data source: Provenance1
name: Adenylosuccinase
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenylosuccinate lyase
name: ADSL
name: Q05911
xref: UnificationXref5065
feature: FragmentFeature909
cellular location: GO:0005829
comment: Reactome DB_ID: 3667706
display name: ASL

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P38009
data source: Provenance1
name: Inosinicase
name: Bifunctional purine biosynthesis protein PURH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP synthetase) (ATIC))
name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
name: IMP cyclohydrolase
name: Bifunctional purine biosynthesis protein PURH
name: P38009
name: IMP synthetase
name: AICAR transformylase
name: Phosphoribosylaminoimidazolecarboxamide formyltransferase
xref: UnificationXref5075
feature: FragmentFeature911
cellular location: GO:0005829
comment: Reactome DB_ID: 3667696
display name: ATIC

UniProt:P22138
type: ProteinReference
xref: UnificationXref6978
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P54113
data source: Provenance1
name: Inosinicase
name: P54113
name: Bifunctional purine biosynthesis protein PURH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP synthetase) (ATIC))
name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
name: IMP cyclohydrolase
name: Bifunctional purine biosynthesis protein PURH
name: IMP synthetase
name: AICAR transformylase
name: Phosphoribosylaminoimidazolecarboxamide formyltransferase
xref: UnificationXref5073
feature: FragmentFeature910
cellular location: GO:0005829
comment: Reactome DB_ID: 3667692
display name: ATIC

http://identifiers.org/pubmed/15798894
type: PublicationXref
id: 15798894
author: Kim, CM
author: Ro, S
author: Jeon, YH
author: Heo, YS
author: Cho, JM
author: Hyun, YL
author: Lee, TG
db: Pubmed
title: Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development
source: Cell Mol Life Sci 62:1198-220
year: 2005

http://identifiers.org/pubmed/21944752
type: PublicationXref
id: 21944752
author: Pierrel, F
author: Lill, R
author: Webert, H
author: Mühlenhoff, U
author: Fontecave, M
author: Ozeir, M
db: Pubmed
title: Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency
source: Chem Biol 18:1134-42
year: 2011

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P39567
data source: Provenance1
name: IMP (inosine monophosphate) dehydrogenase 1
name: Inosine-5'-monophosphate dehydrogenase 1 (EC 1.1.1.205) (IMP dehydrogenase 1) (IMPDH-I) (IMPD 1)
name: IMP dehydrogenase 1
name: P39567
name: IMPDH-I
name: Inosine-5'-monophosphate dehydrogenase 1
name: IMPD 1
xref: UnificationXref5092
feature: FragmentFeature915
cellular location: GO:0005829
comment: Reactome DB_ID: 3667679
display name: IMPDH1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P38697
data source: Provenance1
name: IMP (inosine monophosphate) dehydrogenase 1
name: Inosine-5'-monophosphate dehydrogenase 1 (EC 1.1.1.205) (IMP dehydrogenase 1) (IMPDH-I) (IMPD 1)
name: IMP dehydrogenase 1
name: IMPDH-I
name: P38697
name: Inosine-5'-monophosphate dehydrogenase 1
name: IMPD 1
xref: UnificationXref5094
feature: FragmentFeature916
cellular location: GO:0005829
comment: Reactome DB_ID: 3667683
display name: IMPDH1

http://identifiers.org/pubmed/11470918
type: PublicationXref
id: 11470918
author: Wagner, H
author: Hausmann, S
author: Kirschning, CJ
author: Lipford, GB
author: Bauer, S
author: Redecke, V
author: Akira, S
author: Hacker, H
db: Pubmed
title: Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
source: Proc Natl Acad Sci U S A 98:9237-42
year: 2001

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P39976
data source: Provenance1
name: P39976
name: D-2-hydroxyglutarate dehydrogenase
xref: UnificationXref4936
feature: FragmentFeature902
cellular location: GO:0005759
comment: Reactome DB_ID: 3671459
display name: D2HGDH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P46681
data source: Provenance1
name: P46681
name: D-2-hydroxyglutarate dehydrogenase
xref: UnificationXref4938
feature: FragmentFeature903
cellular location: GO:0005759
comment: Reactome DB_ID: 3671463
display name: D2HGDH

Homologues of D2HGDH
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4939
cellular location: GO:0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3671464

http://identifiers.org/pubmed/11136247
type: PublicationXref
id: 11136247
author: Hurwitz, J
author: Lee, JK
db: Pubmed
title: Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures
source: Proc Natl Acad Sci U S A 98:54-9
year: 2001

Q12480
type: Protein
entity reference: UniProt:Q12480
data source: Provenance1
xref: UnificationXref4978
cellular location: GO:0005759
comment: Reactome DB_ID: 3668916

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q08822
data source: Provenance1
name: Q08822
xref: UnificationXref4986
feature: FragmentFeature905
cellular location: GO:0005759
comment: Reactome DB_ID: 3668928
display name: ETFDH

P10127
type: Protein
entity reference: P10127
data source: Provenance1
xref: UnificationXref4954
cellular location: GO:0005759
comment: Reactome DB_ID: 3671453

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P42940
data source: Provenance1
name: Electron Transfer Flavoprotein beta subunit
name: P42940
name: ETF-beta
xref: UnificationXref4976
feature: FragmentFeature904
cellular location: GO:0005759
comment: Reactome DB_ID: 3668920
display name: ETFB

FGAM synthase
type: Protein
entity reference: UniProt:P38972
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: FGAMS
name: Formylglycinamide ribotide synthetase
name: P38972
name: Phosphoribosylformylglycinamidine synthase
name: Formylglycinamide ribotide amidotransferase
name: FGARAT
xref: UnificationXref5047
feature: FragmentFeature908
cellular location: GO:0005829
comment: Reactome DB_ID: 3667719
display name: PFAS

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
type: Protein
entity reference: P07244
data source: Provenance1
name: GAR transformylase
name: Trifunctional purine biosynthetic protein adenosine-3 (Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase))
name: Trifunctional purine biosynthetic protein adenosine-3
name: GARS
name: AIRS
name: 5'-phosphoribosylglycinamide transformylase
name: Phosphoribosylamine--glycine ligase
name: Glycinamide ribonucleotide synthetase
name: Note: the coordinates are copied over from Homo sapiens.
name: AIR synthase
name: Phosphoribosylformylglycinamidine cyclo-ligase
name: Phosphoribosylglycinamide formyltransferase
name: Phosphoribosyl-aminoimidazole synthetase
name: P07244
name: GART(2-1010)
name: Phosphoribosylglycinamide synthetase
xref: UnificationXref5029
feature: FragmentFeature907
cellular location: GO:0005829
comment: Reactome DB_ID: 3667713
display name: GART

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P04046
data source: Provenance1
name: GPAT
name: Glutamine phosphoribosylpyrophosphate amidotransferase
name: Amidophosphoribosyltransferase precursor (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (GPAT)
name: ATASE
name: Amidophosphoribosyltransferase precursor
name: phosphoribosyl pyrophosphate amidotransferase
name: P04046
name: glutamine phosphoribosylpyrophosphate amidotransferase
name: amidophosphoribosyltransferase
xref: UnificationXref4999
feature: FragmentFeature906
cellular location: GO:0005829
comment: Reactome DB_ID: 3667729
display name: PPAT

http://identifiers.org/pubmed/5666113
type: PublicationXref
id: 5666113
author: Luzzatto, L
author: Afolayan, A
db: Pubmed
title: Enzymic properties of different types of human erythrocyte glucose-6-phosphate dehydrogenase, with characterization of two new genetic variants
source: J Clin Invest 47:1833-42
year: 1968

UnificationXref3900
type: UnificationXref
id: REACT_88140
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88140.9

UnificationXref3901
type: UnificationXref
id: CHEBI:27379
db: ChEBI

UnificationXref3902
type: UnificationXref
id: 192339
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192339

UnificationXref3903
type: UnificationXref
id: REACT_10827
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10827.1

UnificationXref3909
type: UnificationXref
id: 3669349
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669349

UnificationXref3908
type: UnificationXref
id: REACT_10890
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10890.1

UnificationXref3905
type: UnificationXref
id: REACT_81715
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81715.9

UnificationXref3904
type: UnificationXref
id: 3669348
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669348

UnificationXref3907
type: UnificationXref
id: 193403
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193403

UnificationXref3906
type: UnificationXref
id: CHEBI:28533
db: ChEBI

UnificationXref3913
type: UnificationXref
id: REACT_10835
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10835.1

UnificationXref3914
type: UnificationXref
id: CHEBI:16359
db: ChEBI

UnificationXref3911
type: UnificationXref
id: CHEBI:15519
db: ChEBI

UnificationXref3912
type: UnificationXref
id: 192356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192356

UnificationXref3910
type: UnificationXref
id: REACT_83211
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83211.9

UnificationXref3919
type: UnificationXref
id: 3673394
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673394

UnificationXref3918
type: UnificationXref
id: REACT_80492
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80492.9

UnificationXref3917
type: UnificationXref
id: 3669341
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669341

UnificationXref3916
type: UnificationXref
id: REACT_10619
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10619.1

UnificationXref3915
type: UnificationXref
id: 193451
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193451

http://identifiers.org/pubmed/21554866
type: PublicationXref
id: 21554866
author: Cox, Brian J
author: Biechele, Steffen
author: Rossant, Janet
db: Pubmed
title: Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos
source: Dev. Biol. 355:275-85
year: 2011

UnificationXref3937
type: UnificationXref
id: CHEBI:17278
db: ChEBI

UnificationXref3938
type: UnificationXref
id: 193728
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193728

UnificationXref3939
type: UnificationXref
id: REACT_10192
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10192.1

UnificationXref3934
type: UnificationXref
id: REACT_10353
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10353.1

UnificationXref3933
type: UnificationXref
id: 193760
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193760

UnificationXref3936
type: UnificationXref
id: REACT_128336
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128336.5

UnificationXref3935
type: UnificationXref
id: 3669363
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669363

UnificationXref3930
type: UnificationXref
id: 193724
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193724

UnificationXref3932
type: UnificationXref
id: CHEBI:63829
db: ChEBI

UnificationXref3931
type: UnificationXref
id: REACT_10645
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10645.1

UnificationXref3928
type: UnificationXref
id: REACT_156190
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156190.3

UnificationXref3929
type: UnificationXref
id: CHEBI:63838
db: ChEBI

UnificationXref3926
type: UnificationXref
id: REACT_10574
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10574.2

UnificationXref3927
type: UnificationXref
id: 3669364
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669364

UnificationXref3925
type: UnificationXref
id: 193707
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193707

UnificationXref3924
type: UnificationXref
id: CHEBI:63830
db: ChEBI

UnificationXref3923
type: UnificationXref
id: REACT_10249
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10249.1

UnificationXref3922
type: UnificationXref
id: 193745
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193745

UnificationXref3921
type: UnificationXref
id: CHEBI:63839
db: ChEBI

UnificationXref3920
type: UnificationXref
id: REACT_77758
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77758.9

UniProt:P30822
type: ProteinReference
xref: UnificationXref1282
organism: BioSource1

alvespimycin [ChEBI:65324]
type: SmallMoleculeReference
name: alvespimycin
xref: UnificationXref2113

http://identifiers.org/pubmed/2351134
type: PublicationXref
id: 2351134
author: Finocchiaro, G
author: Colombo, I
author: Bloisi, W
author: Giardini, R
author: DiDonato, S
author: Garavaglia, B
db: Pubmed
title: Purification and properties of carnitine acetyltransferase from human liver
source: Eur J Biochem 189:539-46
year: 1990

http://identifiers.org/pubmed/19359157
type: PublicationXref
id: 19359157
author: Lykke-Andersen, J
author: Rebbapragada, I
db: Pubmed
title: Execution of nonsense-mediated mRNA decay: what defines a substrate?
source: Curr Opin Cell Biol 21:394-402
year: 2009

ChEBI:18303 phosphatidyl-L-serine
type: SmallMoleculeReference
name: phosphatidyl-L-serine
xref: UnificationXref4076

UnificationXref3959
type: UnificationXref
id: REACT_10560
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10560.1

http://identifiers.org/pubmed/17698287
type: PublicationXref
id: 17698287
author: Grabowska, AM
author: Watson, SA
db: Pubmed
title: Role of gastrin peptides in carcinogenesis
source: Cancer Lett 257:1-15
year: 2007

UnificationXref3952
type: UnificationXref
id: REACT_10707
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10707.1

UnificationXref3951
type: UnificationXref
id: 193741
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193741

UnificationXref3954
type: UnificationXref
id: REACT_112002
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112002.8

UnificationXref3953
type: UnificationXref
id: 3669366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669366

UnificationXref1013
type: UnificationXref
id: 3673071
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673071

UnificationXref3956
type: UnificationXref
id: 193778
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193778

UnificationXref1012
type: UnificationXref
id: REACT_34288
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34288.10

UnificationXref3955
type: UnificationXref
id: CHEBI:27403
db: ChEBI

UnificationXref1011
type: UnificationXref
id: 3673332
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673332

UnificationXref3958
type: UnificationXref
id: 193739
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193739

UnificationXref1010
type: UnificationXref
id: REACT_107926
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107926.9

UnificationXref3957
type: UnificationXref
id: REACT_10236
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10236.1

UnificationXref1017
type: UnificationXref
id: CHEBI:17677
db: ChEBI

UnificationXref1016
type: UnificationXref
id: REACT_87718
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87718.9

UnificationXref1015
type: UnificationXref
id: 3673072
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673072

UnificationXref1014
type: UnificationXref
id: REACT_104577
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104577.9

http://identifiers.org/pubmed/7378348
type: PublicationXref
id: 7378348
author: So, AG
author: Tan, CK
author: Downey, KM
author: Lee, MY
db: Pubmed
title: Purification of deoxyribonucleic acid polymerase delta from calf thymus: partial characterization of physical properties.
source: Biochemistry 19:2096-101
year: 1980

UnificationXref1019
type: UnificationXref
id: REACT_2826
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2826.1

UnificationXref3950
type: UnificationXref
id: CHEBI:27458
db: ChEBI

UnificationXref1018
type: UnificationXref
id: 29470
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29470

http://identifiers.org/pubmed/22362766
type: PublicationXref
id: 22362766
author: Pallesen, Leif J
author: Walden, William E
author: Netz, Daili J A
author: Bill, Eckhard
author: Sharma, Anil K
author: Stümpfig, Martin
author: Lill, R
author: Pierik, Antonio J
db: Pubmed
title: A bridging [4Fe-4S] cluster and nucleotide binding are essential for function of the Cfd1-Nbp35 complex as a scaffold in iron-sulfur protein maturation
source: J. Biol. Chem. 287:12365-78
year: 2012

Import of palmitoyl-CoA into the mitochondrial matrix
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction222
pathway component: BiochemicalReaction221
evidence: Evidence380
xref: RelationshipXref293
xref: UnificationXref3413
xref: UnificationXref3412
pathway order: PathwayStep376
pathway order: PathwayStep377
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3948
type: UnificationXref
id: 193762
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193762

UnificationXref3949
type: UnificationXref
id: REACT_10686
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10686.1

UnificationXref3943
type: UnificationXref
id: 213285
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213285

UnificationXref3942
type: UnificationXref
id: CHEBI:63831
db: ChEBI

UnificationXref3941
type: UnificationXref
id: REACT_159385
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159385.3

UnificationXref3940
type: UnificationXref
id: 3669367
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669367

UnificationXref1000
type: UnificationXref
id: 68424
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=68424

UnificationXref3947
type: UnificationXref
id: CHEBI:63824
db: ChEBI

UnificationXref3946
type: UnificationXref
id: REACT_130597
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130597.5

UnificationXref1002
type: UnificationXref
id: 3665916
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3665916

UnificationXref3945
type: UnificationXref
id: 3669365
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669365

UnificationXref1001
type: UnificationXref
id: REACT_2531
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2531.1

UnificationXref3944
type: UnificationXref
id: REACT_13314
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13314.1

UnificationXref1004
type: UnificationXref
id: REACT_3748
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3748.1

UnificationXref1003
type: UnificationXref
id: 113499
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113499

UnificationXref1006
type: UnificationXref
id: REACT_2843
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2843.2

UnificationXref1005
type: UnificationXref
id: 113656
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113656

UnificationXref1008
type: UnificationXref
id: REACT_94472
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94472.9

UnificationXref1007
type: UnificationXref
id: 3668589
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668589

UnificationXref1009
type: UnificationXref
id: 3673331
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673331

http://identifiers.org/pubmed/8089153
type: PublicationXref
id: 8089153
author: Hirst, M
author: Lou, L
author: Nakamura, J
author: Haliday, E
db: Pubmed
title: Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA
source: J Biol Chem 269:23830-23837
year: 1994

UniProt:P28272
type: ProteinReference
xref: UnificationXref5265
organism: BioSource1

UniProt:P28274
type: ProteinReference
xref: UnificationXref5411
organism: BioSource1

UnificationXref3970
type: UnificationXref
id: REACT_10863
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10863.1

UnificationXref3971
type: UnificationXref
id: CHEBI:48834
db: ChEBI

UnificationXref3972
type: UnificationXref
id: 193829
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193829

UnificationXref1038
type: UnificationXref
id: REACT_2773
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2773.1

UnificationXref1039
type: UnificationXref
id: CHEBI:16284
db: ChEBI

UnificationXref1036
type: UnificationXref
id: CHEBI:18077
db: ChEBI

UnificationXref1037
type: UnificationXref
id: 30187
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30187

UnificationXref1034
type: UnificationXref
id: 29892
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29892

UnificationXref3977
type: UnificationXref
id: 193835
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193835

UnificationXref1035
type: UnificationXref
id: REACT_4670
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4670.1

UnificationXref3978
type: UnificationXref
id: REACT_10821
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10821.1

UnificationXref1032
type: UnificationXref
id: REACT_5885
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5885.1

UnificationXref3979
type: UnificationXref
id: CHEBI:48778
db: ChEBI

UnificationXref1033
type: UnificationXref
id: CHEBI:16497
db: ChEBI

UnificationXref1030
type: UnificationXref
id: CHEBI:16311
db: ChEBI

UnificationXref3973
type: UnificationXref
id: REACT_10380
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10380.2

UnificationXref1031
type: UnificationXref
id: 30185
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30185

UnificationXref3974
type: UnificationXref
id: 3669369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669369

UnificationXref3975
type: UnificationXref
id: REACT_153889
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153889.3

UnificationXref3976
type: UnificationXref
id: CHEBI:48825
db: ChEBI

Synthesis of bile acids and bile salts
type: Pathway
data source: Provenance1
pathway component: REACT 77758.9
pathway component: BiochemicalReaction292
pathway component: REACT 155779.3
pathway component: REACT 98081.9
evidence: Evidence471
xref: UnificationXref4007
xref: UnificationXref4006
xref: RelationshipXref368
pathway order: PathwayStep453
pathway order: PathwayStep462
pathway order: PathwayStep467
pathway order: PathwayStep468
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11425315
type: PublicationXref
id: 11425315
author: Peng, H
author: Liu, Q
author: Golde, DW
author: Vera, JC
db: Pubmed
title: The predicted ATP-binding domains in the hexose transporter GLUT1 critically affect transporter activity.
source: Biochemistry 40:7874-81
year: 2001

UnificationXref1029
type: UnificationXref
id: REACT_83496
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83496.9

UnificationXref3960
type: UnificationXref
id: 3669360
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669360

UnificationXref3961
type: UnificationXref
id: REACT_114641
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114641.8

UnificationXref1025
type: UnificationXref
id: REACT_3782
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3782.1

UnificationXref1026
type: UnificationXref
id: 30595
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30595

UnificationXref1027
type: UnificationXref
id: REACT_4491
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4491.1

UnificationXref1028
type: UnificationXref
id: 3665688
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3665688

UnificationXref1021
type: UnificationXref
id: 113571
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113571

UnificationXref3968
type: UnificationXref
id: CHEBI:48333
db: ChEBI

UnificationXref1022
type: UnificationXref
id: REACT_5587
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5587.1

UnificationXref3969
type: UnificationXref
id: 193813
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193813

UnificationXref1023
type: UnificationXref
id: CHEBI:15713
db: ChEBI

UnificationXref3966
type: UnificationXref
id: 3673399
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673399

UnificationXref1024
type: UnificationXref
id: 113562
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113562

UnificationXref3967
type: UnificationXref
id: REACT_98081
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98081.9

UnificationXref3964
type: UnificationXref
id: 3669362
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669362

UnificationXref3965
type: UnificationXref
id: REACT_114408
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114408.8

UnificationXref3962
type: UnificationXref
id: 3669361
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669361

UnificationXref1020
type: UnificationXref
id: CHEBI:15996
db: ChEBI

UnificationXref3963
type: UnificationXref
id: REACT_90069
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90069.9

http://identifiers.org/pubmed/17635743
type: PublicationXref
id: 17635743
author: Bluteau, D
author: Debili, N
author: Chang, Y
author: Vainchenker, W
db: Pubmed
title: From hematopoietic stem cells to platelets
source: J Thromb Haemost 5:318-27
year: 2007

UnificationXref1060
type: UnificationXref
id: 3665898
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3665898

Pyruvate
type: SmallMoleculeReference
name: Pyruvic acid
name: Pyroracemic acid
name: 2-Oxopropanoate
name: 2-Oxopropanoic acid
name: Pyruvate [ChEBI:32816]
xref: UnificationXref379

UnificationXref1058
type: UnificationXref
id: 3665860
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3665860

UnificationXref1059
type: UnificationXref
id: P32496
db: UniProt

UnificationXref3990
type: UnificationXref
id: REACT_10427
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10427.1

UnificationXref3991
type: UnificationXref
id: 3669371
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669371

UnificationXref3992
type: UnificationXref
id: REACT_156500
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156500.3

UnificationXref3993
type: UnificationXref
id: 3673400
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673400

UnificationXref3994
type: UnificationXref
id: REACT_155779
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155779.3

UnificationXref1052
type: UnificationXref
id: 3665766
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3665766

UnificationXref3995
type: UnificationXref
id: CHEBI:42977
db: ChEBI

UnificationXref1053
type: UnificationXref
id: 3665767
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3665767

UnificationXref3996
type: UnificationXref
id: 192148
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192148

UnificationXref1050
type: UnificationXref
id: 3665765
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3665765

UnificationXref3997
type: UnificationXref
id: REACT_10566
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10566.1

UnificationXref1051
type: UnificationXref
id: REACT_131881
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131881.5

UnificationXref3998
type: UnificationXref
id: P38992
db: UniProt

UnificationXref1056
type: UnificationXref
id: REACT_126352
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126352.5

UnificationXref3999
type: UnificationXref
id: 3669312
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669312

UnificationXref1057
type: UnificationXref
id: P32565
db: UniProt

UnificationXref1054
type: UnificationXref
id: 3665768
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3665768

UnificationXref1055
type: UnificationXref
id: 3665769
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3665769

UnificationXref1047
type: UnificationXref
id: 3665763
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3665763

UnificationXref1048
type: UnificationXref
id: 3665759
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3665759

http://identifiers.org/pubmed/14521508
type: PublicationXref
id: 14521508
author: Fransson, A
author: Aspenstrom, P
author: Saras, J
db: Pubmed
title: Rho GTPases have diverse effects on the organization of the actin filament system
source: Biochem J 377:327-37
year: 2004

UnificationXref1049
type: UnificationXref
id: 3665764
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3665764

UnificationXref3982
type: UnificationXref
id: 3669370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669370

http://identifiers.org/pubmed/19261609
type: PublicationXref
id: 19261609
author: Vitvitsky, V
author: Singh, S
author: Banerjee, R
author: Zhu, W
author: Chiku, T
author: Padovani, D
db: Pubmed
title: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia
source: J Biol Chem 284:11601-12
year: 2009

UnificationXref3983
type: UnificationXref
id: REACT_155432
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155432.3

UniProt:P28241
type: ProteinReference
xref: UnificationXref4869
organism: BioSource1

UnificationXref3980
type: UnificationXref
id: 193830
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193830

UnificationXref3981
type: UnificationXref
id: REACT_10201
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10201.1

UnificationXref3986
type: UnificationXref
id: 3669368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669368

UnificationXref1040
type: UnificationXref
id: 29604
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29604

UnificationXref3987
type: UnificationXref
id: REACT_154209
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154209.3

UnificationXref1041
type: UnificationXref
id: REACT_5621
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5621.1

UnificationXref3984
type: UnificationXref
id: 193843
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193843

UnificationXref1042
type: UnificationXref
id: 3665918
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3665918

UnificationXref3985
type: UnificationXref
id: REACT_10938
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10938.1

UnificationXref1043
type: UnificationXref
id: REACT_85611
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85611.9

UnificationXref1044
type: UnificationXref
id: 3673067
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673067

UnificationXref1045
type: UnificationXref
id: REACT_89418
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89418.9

UnificationXref3988
type: UnificationXref
id: CHEBI:28540
db: ChEBI

UnificationXref1046
type: UnificationXref
id: P05759
db: UniProt

UnificationXref3989
type: UnificationXref
id: 193842
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193842

ChEBI:53023 (GlcNAc)2 (Man)6 (PP-Dol)1
type: SmallMoleculeReference
name: (GlcNAc)2 (Man)6 (PP-Dol)1
xref: UnificationXref9638

http://identifiers.org/pubmed/8428657
type: PublicationXref
id: 8428657
author: Yang, DC
author: Donovan, D
author: Vogeli, G
author: Vilalta, A
author: Wood, L
db: Pubmed
title: Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase
source: Gene 123:181-6
year: 1993

http://identifiers.org/pubmed/16024644
type: PublicationXref
id: 16024644
author: Shimamura, T
author: Shapiro, GI
author: Engelman, JA
author: Lowell, AM
db: Pubmed
title: Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
source: Cancer Res 65:6401-8
year: 2005

http://identifiers.org/pubmed/9268380
type: PublicationXref
id: 9268380
author: Fattaey, A
author: Booher, RN
author: Holman, PS
db: Pubmed
title: Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity
source: J Biol Chem 272:22300-6
year: 1997

http://identifiers.org/pubmed/17222168
type: PublicationXref
id: 17222168
author: Agre, P
author: Frøkiaer, J
author: Nielsen, S
author: Kwon, TH
db: Pubmed
title: Regulation and dysregulation of aquaporins in water balance disorders
source: J Intern Med 261:53-64
year: 2007

Recycling of eIF2:GDP
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction655
pathway component: BiochemicalReaction656
evidence: Evidence986
xref: UnificationXref7750
xref: UnificationXref7751
pathway order: PathwayStep998
pathway order: PathwayStep997
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Glycerophospholipid biosynthesis
type: Pathway
data source: Provenance1
pathway component: REACT 147125.5
pathway component: REACT 143542.5
pathway component: REACT 141626.5
pathway component: REACT 136883.5
pathway component: REACT 139496.5
pathway component: Synthesis of CL
pathway component: REACT 140144.5
pathway component: REACT 139337.5
pathway component: REACT 146495.5
pathway component: Acyl chain remodeling of DAG and TAG
pathway component: REACT 135906.5
pathway component: Acyl chain remodelling of PI
pathway component: Synthesis of PG
pathway component: REACT 136119.5
pathway component: REACT 133624.5
evidence: Evidence518
xref: RelationshipXref424
xref: UnificationXref4281
xref: UnificationXref4282
pathway order: PathwayStep497
pathway order: PathwayStep481
pathway order: PathwayStep489
pathway order: PathwayStep486
pathway order: PathwayStep508
pathway order: PathwayStep494
pathway order: PathwayStep475
pathway order: PathwayStep510
pathway order: PathwayStep484
pathway order: PathwayStep499
pathway order: PathwayStep492
pathway order: PathwayStep505
pathway order: PathwayStep502
pathway order: PathwayStep477
pathway order: PathwayStep515
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

(Glc)2 (GlcNAc)2 (Man)9 (PP-Dol)1
type: SmallMoleculeReference
name: ChEBI:53020 (Glc)2 (GlcNAc)2 (Man)9 (PP-Dol)1
xref: UnificationXref9673

ChEBI:53022 (GlcNAc)2 (Man)5 (PP-Dol)1
type: SmallMoleculeReference
name: (GlcNAc)2 (Man)5 (PP-Dol)1
xref: UnificationXref9617

ChEBI:53014 N(6)-carboxymethyl-L-lysine
type: SmallMoleculeReference
name: N(6)-carboxymethyl-L-lysine
xref: UnificationXref9254

(Glc)3 (GlcNAc)2 (Man)9 (PP-Dol)1
type: SmallMoleculeReference
name: ChEBI:53019 (Glc)3 (GlcNAc)2 (Man)9 (PP-Dol)1
xref: UnificationXref9680

Activation of Chaperone Genes by XBP1(S)
type: Pathway
data source: Provenance1
pathway component: TemplateReaction15
pathway component: TemplateReaction20
pathway component: TemplateReaction28
pathway component: TemplateReaction25
pathway component: TemplateReaction22
pathway component: TemplateReaction23
pathway component: TemplateReaction31
pathway component: TemplateReaction24
pathway component: TemplateReaction27
pathway component: TemplateReaction30
pathway component: TemplateReaction18
pathway component: TemplateReaction16
pathway component: TemplateReaction21
pathway component: TemplateReaction19
pathway component: TemplateReaction26
pathway component: TemplateReaction17
pathway component: TemplateReaction29
evidence: Evidence1440
xref: UnificationXref9889
xref: UnificationXref9890
pathway order: PathwayStep1430
pathway order: PathwayStep1441
pathway order: PathwayStep1437
pathway order: PathwayStep1438
pathway order: PathwayStep1445
pathway order: PathwayStep1436
pathway order: PathwayStep1444
pathway order: PathwayStep1446
pathway order: PathwayStep1431
pathway order: PathwayStep1433
pathway order: PathwayStep1440
pathway order: PathwayStep1432
pathway order: PathwayStep1443
pathway order: PathwayStep1435
pathway order: PathwayStep1442
pathway order: PathwayStep1434
pathway order: PathwayStep1439
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/17222174
type: PublicationXref
id: 17222174
author: Van Schaftingen, E
author: Linster, CL
db: Pubmed
title: Vitamin C: biosynthesis, recycling and degradation in mammals
source: FEBS J 274:1-22
year: 2007

http://identifiers.org/pubmed/11264579
type: PublicationXref
id: 11264579
author: Hutson, SM
author: Conway, ME
author: Dunbar, J
author: Farber, GK
author: Yennawar, NH
db: Pubmed
title: The structure of human mitochondrial branched-chain aminotransferase.
source: Acta Crystallogr D Biol Crystallogr 57:506-15
year: 2001

http://identifiers.org/pubmed/18767960
type: PublicationXref
id: 18767960
author: Antonellis, A
author: Green, ED
db: Pubmed
title: The role of aminoacyl-tRNA synthetases in genetic diseases
source: Annu Rev Genomics Hum Genet 9:87-107
year: 2008

http://identifiers.org/pubmed/2995985
type: PublicationXref
id: 2995985
author: Evans, DR
author: Kelly, RE
author: Pastra-Landis, SC
author: Lee, L
db: Pubmed
title: Oligomeric structure of the multifunctional protein CAD that initiates pyrimidine biosynthesis in mammalian cells
source: Proc Natl Acad Sci USA 82:6802-6806
year: 1985

http://identifiers.org/pubmed/6022858
type: PublicationXref
id: 6022858
author: Younathan, ES
author: Pynes, GD
db: Pubmed
title: Purification and some properties of inorganic pyrophosphatase from human erythrocytes
source: J Biol Chem 242:2119-23
year: 1967

6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositols
type: SmallMoleculeReference
name: 6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol [ChEBI:53059]
name: 6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol
xref: UnificationXref9475

(GlcN)1 (Ino(acyl)-P)1 (Man)2 (EtN)1 (P)1
type: SmallMoleculeReference
xref: UnificationXref9465

6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositols
type: SmallMoleculeReference
name: 6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol
name: 6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol [ChEBI:53056]
xref: UnificationXref9450

http://identifiers.org/pubmed/1335363
type: PublicationXref
id: 1335363
author: Birnbaumer, L
db: Pubmed
title: Receptor-to-effector signaling through G proteins: roles for beta gamma dimers as well as alpha subunits
source: Cell 71:1069-72
year: 1992

http://identifiers.org/pubmed/9305914
type: PublicationXref
id: 9305914
author: Ishimi, Y
db: Pubmed
title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
source: J Biol Chem 272:24508-13
year: 1997

http://identifiers.org/pubmed/14638695
type: PublicationXref
id: 14638695
author: Lu, M
author: Haney, LB
author: Brugnera, E
author: Hengartner, MO
author: Tosello-Trampont, AC
author: Klingele, D
author: Ravichandran, KS
author: Kinchen, JM
author: Chen, Q
author: Grimsley, CM
db: Pubmed
title: Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration
source: J Biol Chem 279:6087-97
year: 2004

http://identifiers.org/pubmed/8114698
type: PublicationXref
id: 8114698
author: Nevins, JR
author: Ohtani, K
db: Pubmed
title: Functional properties of a Drosophila homolog of the E2F1 gene
source: Mol Cell Biol 14:1603-12
year: 1994

http://identifiers.org/pubmed/20188670
type: PublicationXref
id: 20188670
author: Riemer, J
author: Wagener, N
author: Chwalla, I
author: Herrmann, JM
author: Longen, S
author: Bien, M
db: Pubmed
title: Mitochondrial disulfide bond formation is driven by intersubunit electron transfer in Erv1 and proofread by glutathione
source: Mol Cell 37:516-28
year: 2010

UniProt:Q12403
type: ProteinReference
xref: UnificationXref9198
organism: BioSource1

ChEBI:27403 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
type: SmallMoleculeReference
name: 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
xref: UnificationXref3955

UniProt:P24583
type: ProteinReference
xref: UnificationXref1990
organism: BioSource1

http://identifiers.org/pubmed/15581364
type: PublicationXref
id: 15581364
author: Zhai, H
author: McLafferty, FW
author: Brand, LA
author: Begley, TP
author: Strauss, E
db: Pubmed
title: Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent
source: Biochemistry 43:15520-33
year: 2004

http://identifiers.org/pubmed/26687
type: PublicationXref
id: 26687
author: Shimizu, T
author: Nomiyama, S
author: Hayaishi, O
author: Hirata, F
db: Pubmed
title: Indoleamine 2,3-dioxygenase. Purification and some properties
source: J Biol Chem 253:4700-4706
year: 1978

UniProt:P51862
type: ProteinReference
xref: UnificationXref8554
organism: BioSource1

http://identifiers.org/pubmed/10522552
type: PublicationXref
id: 10522552
author: Ponka, P
db: Pubmed
title: Cell biology of heme
source: Am J Med Sci 318:241-56
year: 1999

http://identifiers.org/pubmed/16116451
type: PublicationXref
id: 16116451
author: Szabó, SI
author: Makara, JK
author: Fegley, D
author: Freund, TF
author: Tontini, A
author: Duranti, A
author: Mor, M
author: Astarita, G
author: Piomelli, D
author: Rivara, S
author: Tarzia, G
author: Kathuria, S
db: Pubmed
title: Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
source: Nat Neurosci 8:1139-41
year: 2005

http://identifiers.org/pubmed/12949583
type: PublicationXref
id: 12949583
author: van den Bosch, M
author: Lowndes, NF
author: Bree, RT
db: Pubmed
title: The MRN complex: coordinating and mediating the response to broken chromosomes.
source: EMBO Rep 4:844-9
year: 2003

UniProt:P20107
type: ProteinReference
xref: UnificationXref8180
organism: BioSource1

PublicationXref1644
type: PublicationXref
author: Kassavetis, G
title: RNA polymerase III Transcription Complexes
source: Transcriptional Regulation, eds. McKnight, S.L., Yamamoto, K.R. 22:247-280
year: 1992

http://identifiers.org/pubmed/2995393
type: PublicationXref
id: 2995393
author: Fitzpatrick, F
author: McGee, J
db: Pubmed
title: Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes
source: J Biol Chem 260:12832-7
year: 1985

Inositol phosphate metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 155678.3
pathway component: REACT 155187.3
pathway component: REACT 153973.3
pathway component: REACT 153757.3
evidence: Evidence358
xref: UnificationXref3248
xref: RelationshipXref236
xref: UnificationXref3249
pathway order: PathwayStep349
pathway order: PathwayStep355
pathway order: PathwayStep332
pathway order: PathwayStep338
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/19297525
type: PublicationXref
id: 19297525
author: Chacinska, A
author: Stojanovski, D
author: Milenkovic, D
author: Gebert, N
author: Schulze-Specking, A
author: Ramming, T
author: Müller, JM
author: Wenz, LS
author: Rospert, S
db: Pubmed
title: Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria
source: Mol Biol Cell 20:2530-9
year: 2009

2'-deoxyinosine
type: SmallMoleculeReference
name: deoxyinosine
name: 2'-deoxyinosine [ChEBI:28997]
xref: UnificationXref5187

Removal of licensing factors from origins
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction51
pathway component: REACT 86490.9
pathway component: REACT 146407.5
evidence: Evidence114
xref: UnificationXref1234
xref: UnificationXref1235
pathway order: PathwayStep102
pathway order: PathwayStep101
pathway order: PathwayStep97
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11278486
type: PublicationXref
id: 11278486
author: Chong, C
author: Tan, L
author: Lim, L
author: Manser, E
db: Pubmed
title: The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
source: J Biol Chem 276:17347-53
year: 2001

Nitric oxide stimulates guanylate cyclase
type: Pathway
data source: Provenance1
pathway component: REACT 154377.3
evidence: Evidence1001
xref: UnificationXref7840
xref: UnificationXref7841
pathway order: PathwayStep1012
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence1020
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8424766
comment: Activation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium and activation of Protein Kinase C (PKC). Phospholipase C cleaves the phosphodiester bond in PIP2 to form 1,2 Diacylglycerol (DAG) and 1,4,5-inositol trisphosphate (IP3). IP3 opens Ca2+ channels in the platelet dense tubular system, raising intracellular Ca2+ levels. DAG is a second messenger that regulates a family of Ser/Thr kinases consisting of PKC isozymes (Nishizuka 1995). DAG achieves activation of PKC isozymes by increasing their affinity for phospholipid. Most PKC enzymes are also calcium-dependent, so their activation is in synergy with the rise in intracellular Ca2+. Platelets contain several PKC isoforms that can be activated by DAG and/or Ca2+ (Chang 1997).

UniProt:Q02939
type: ProteinReference
xref: UnificationXref2289
organism: BioSource1

Evidence1021
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12411949
xref: http://identifiers.org/pubmed/8704248
xref: http://identifiers.org/pubmed/17059469
xref: http://identifiers.org/pubmed/1672265
xref: http://identifiers.org/pubmed/16543958
xref: http://identifiers.org/pubmed/2018971
xref: http://identifiers.org/pubmed/11511514
xref: http://identifiers.org/pubmed/12681240
comment: Platelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the platelet membrane (Ruggeri 2002). Intracellular signaling reactions then enhance the adhesive and procoagulant properties of tethered platelets or of platelets circulating in the proximity. Once platelets have adhered they degranulate, releasing stored secondary agents such as ADP, ATP, and synthesize thromboxane A2. These amplify the response, activating and recruiting further platelets to the area and promoting platelet aggregation. These amplify the response, activating and recruiting further platelets to the area and promoting platelet aggregation. Adenosine nucleotides signal through P2 purinergic receptors on the platelet membrane. ADP activates P2Y1 and P2Y12, which signal via both the alpha and gamma:beta components of the heterotrimeric G-protein (Hirsch et al. 2001, 2006), while ATP activates the ionotropic P2X1 receptor (Kunapuli et al. 2003). Activation of these receptors initiates a complex signaling cascade that ultimately results in platelet activation, aggregation and thrombus formation (Kahner et al. 2006). Integrin AlphaIIbBeta3 is the most abundant platelet receptor, with 40 000 to 80 000 copies per resting platelet, acting as a major receptor for fibrinogen and other adhesive molecules (Wagner et al. 1996). Activation of AlphaIIbBeta3 enhances adhesion and leads to platelet-platelet interactions, and thus aggregation (Philips et al. 1991). GP VI is the most potent collagen receptor initiating signal generation, an ability derived from its interaction with the FcRI gamma chain. This results in the phosphorylation of the gamma-chain by non-receptor tyrosine kinases of the Src family (1). The phosphotyrosine motif is recognized by the SH2 domains of Syk, a tyrosine kinase. This association activates the Syk enzyme, leading to activation (by tyrosine phospho…

http://identifiers.org/pubmed/12123609
type: PublicationXref
id: 12123609
author: Snider, WD
author: Zhong, J
author: Markus, A
db: Pubmed
title: Raf and akt mediate distinct aspects of sensory axon growth
source: Neuron 35:65-76
year: 2002

Evidence1023
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref1874
xref: http://identifiers.org/pubmed/218813
comment: GTP-AMP phosphotransferase, also called Adenylate kinase 3 catalyzes phosphate transfer from GTP to AMP (EC 2.7.4.10). A crystal structure is available (Choe et al. 2005).

Evidence1022
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9331217
comment: F-actin-capping protein binds in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits. Unlike other capping proteins (such as gelsolin and severin), they do not sever actin filaments.

Evidence1025
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15247287
xref: http://identifiers.org/pubmed/15710388
xref: http://identifiers.org/pubmed/16025104
xref: http://identifiers.org/pubmed/12134158
xref: http://identifiers.org/pubmed/17765544
xref: http://identifiers.org/pubmed/17196961
xref: http://identifiers.org/pubmed/17027967
xref: http://identifiers.org/pubmed/12432077
xref: http://identifiers.org/pubmed/14638695
comment: Members of the Dedicator of cytokinesis (DOCK) family, also known as the Dock180 superfamily, are Rho GTPase guanine nucleotide exchange factors (GEFs), modulating Rho GTPase activity (Cote & Vuori 2002). All eleven human members share the presence of two evolutionarily conserved protein domains, termed DHR-1 and DHR-2 (Cote & Vuori 2007). The DHR-2 domains of several DOCKs interact with the nucleotide-free forms of Rho GTPases, intermediates in the catalytic reaction leading to the exchange of GDP for GTP. DHR-2 domains have been shown necessary and sufficient to promote specific guanine nucleotide exchange on various Rho GTPases, both in vitro and in vivo. Inactivation of the DHR-2 domain in DOCK1 (Dock180) has been shown to block Rac activation, cell migration and phagocytosis (Brugnera et al. 2002, Grimsley et al. 2004, Cote & Vuori 2002). The DHR-1 domain of DOCK1 was shown to mediate a specific interaction with PIP2 and PIP3 signaling lipids in vitro and in cells (Cote et al. 2005). Mutations of the DOCK1 DHR-1 domain blocked Rac-dependent cell elongation and cell migration suggesting that the role of DHR-1 is to position DOCK1 at sites of PIP3 production by PI3-kinase, coupling this to Rac signaling (Cote & Vuori 2007).

Evidence1024
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11062261
xref: http://identifiers.org/pubmed/10811830
xref: http://identifiers.org/pubmed/10559924
comment: The small GTPase Rab5 regulates membrane traffic into and between early endosomes by specifically recruiting cytosolic effector proteins to their site of action on early endosomal membranes. Rab5 occupies a restricted membrane subdomain on endosomes that has distinct biochemical features when compared with neighboring subcompartments (Sonnichsen et al. 2000). Rab5 is believed to form this subdomain by recruiting the specific PI3 kinase VPS-45, causing localized production of PI-3-phosphate (PI-3P) (Christoforidis et al. 1999). Rabenosyn-5 is a Rab5 effector, recruited in a phosphatidylinositol-3-kinase dependent fashion to early endosomes where it serves as a molecular link between VPS-45 and Rab5.

Evidence1027
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8548803
xref: http://identifiers.org/pubmed/17846176
xref: http://identifiers.org/pubmed/8083185
xref: http://identifiers.org/pubmed/15875026
comment: Kinesin-5 motors are bipolar homotetramers with two motor domains at each end, separated by a stalk/tail region (Cole et al. 1994). During mitosis, Kinesin-5 motors function near the spindle midzone to maintain pole to pole distance. Motor domains attach to microtubules from opposite poles and translocate towards the plus ends, thereby pushing the spindle poles apart (Kapitein et al. 2005). Kinesin-5 is also involved in axon growth (Myers & Baas 2007).

Evidence1026
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15326200
xref: http://identifiers.org/pubmed/12606572
xref: http://identifiers.org/pubmed/15946846
xref: http://identifiers.org/pubmed/8599929
xref: http://identifiers.org/pubmed/7929562
comment: Chromokinesins consist of the kinesin-4 and kinesin-10 families.They act in various steps of mitosis, including chromosome condensation, metaphase alignment, chromosome segregation and cytokinesis (Mazumdar & Misteli 2005). Both families consist of homodimeric microtubule-based plus-end directed motor proteins (Sekine et al. 1994, Yajima et al. 2003).

http://identifiers.org/pubmed/7028108
type: PublicationXref
id: 7028108
author: Olson, RE
author: Goewert, RR
author: Grimm, MF
author: Sippel, CJ
db: Pubmed
title: Identification of 3-methoxy-4-hydroxy-5-hexaprenylbenzoic acid as a new intermediate in ubiquinone biosynthesis by Saccharomyces cerevisiae
source: Biochemistry 20:5611-6
year: 1981

Evidence1029
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16906145
xref: http://identifiers.org/pubmed/18692476
xref: http://identifiers.org/pubmed/9060472
xref: http://identifiers.org/pubmed/18267093
xref: http://identifiers.org/pubmed/17346968
comment: Kinesin-8 is a plus-end-directed dimeric kinesin with an internal motor domain (Loughlin et al. 2008) that can depolymerize stable microtubuless specifically at their plus-ends (Pereira et al. 1997) in a length-dependent manner (Varga et al. 2006). Human kinesin-8 KIF18A is believed to promote chromosome congression by attenuating chromosome oscillation magnitudes (Stumpff et al. 2008).

Evidence1028
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12361599
xref: http://identifiers.org/pubmed/18342609
xref: http://identifiers.org/pubmed/2022189
xref: http://identifiers.org/pubmed/8743943
comment: Human kinesin-7, or CENP-E was one of the first kinesins to be discovered (Yen et al. 1991). It is essential for mammalian development, having a role in stabilizing kinetochore-microtubule capture (Putkey et al. 2002), CENP-E is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules and localizes to kinetochores throughout all phases of mitotic chromosome movement (early premetaphase through anaphase A). Though originally reported to be minus-end-directed it is now believed to be a plus-end-directed dimeric kinesin (Espeut et al. 2008). It is sequestered in the cytoplasm until nuclear envelope breakdown and then localizes to its chromosomal cargo at the kinetochores (Brown et al. 1996).

http://identifiers.org/pubmed/10958673
type: PublicationXref
id: 10958673
author: Yoshida, H
author: Haze, K
author: Yura, T
author: Yanagi, H
author: Mori, K
author: Okada, T
author: Negishi, M
db: Pubmed
title: ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
source: Mol Cell Biol 20:6755-67
year: 2000

http://identifiers.org/pubmed/18772128
type: PublicationXref
id: 18772128
author: Riekhof, WR
author: Voelker, DR
author: Gijon, MA
author: Zarini, S
author: Murphy, RC
db: Pubmed
title: Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils
source: J Biol Chem 283:30235-45
year: 2008

Evidence1010
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6788766
xref: http://identifiers.org/pubmed/11588122
xref: http://identifiers.org/pubmed/3102469
xref: http://identifiers.org/pubmed/7295321
xref: PublicationXref1853
comment: Diacylglycerol (DAG) is an important source of arachidonic acid, a signalling molecule and the precursor of the prostaglandins. In human platelet almost all the DAG produced from phosphatidylinositol degradation contains arachidonate (Takamura et al. 1987). DAG is hydrolysed by DAG lipase to 2-arachidonylglycerol (2-AG) which is further hydrolysed by monoacylglycerol lipase. 2-AG is an agonist of cannabinoid receptor 1.

http://identifiers.org/pubmed/19935646
type: PublicationXref
id: 19935646
author: Jang, HG
author: Dang, L
author: Keenan, MC
author: Vander Heiden, MG
author: Bennett, BD
author: Rabinowitz, JD
author: Driggers, EM
author: Gross, S
author: Ward, PS
author: Fantin, VR
author: Thompson, CB
author: Cantley, LC
author: Marks, KM
author: White, DW
author: Bittinger, MA
author: Prins, RM
author: Su, SM
author: Yen, KE
author: Liau, LM
author: Jin, S
db: Pubmed
title: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
source: Nature 462:739-44
year: 2009

UniProt:P49017 COQ5
type: ProteinReference
name: YM8339.09C
name: DBI56
name: COQ5
name: YML110C
xref: UnificationXref4738
comment: FUNCTION Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).CATALYTIC ACTIVITY S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.PATHWAY Cofactor biosynthesis; ubiquinone biosynthesis.MISCELLANEOUS Present with 8100 molecules/cell in log phase SD medium.SIMILARITY Belongs to the methyltransferase superfamily. UbiE family.
organism: BioSource1

Evidence1019
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref1835
xref: http://identifiers.org/pubmed/14630798
comment: Platelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules, dense granules and lysosomes. On activation platelets release a variety of proteins, largely from storage granules but also as the result of apparent cell lysis. These act in an autocrine or paracrine fashion to modulate cell signaling. Alpha granules contain mainly polypeptides such as fibrinogen, von Willebrand factor, growth factors and protease inhibitors that that supplement thrombin generation at the site of injury. Dense granules contain small molecules, particularly adenosine diphosphate (ADP), adenosine triphosphate (ATP), serotonin and calcium, all recruit platelets to the site of injury.

Evidence1014
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10856305
comment: At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'Syntaxin 4' are present. At the end of this reaction, 1 molecule of 'Phosphorylated syntaxin 4', and 1 molecule of 'ADP' are present. This reaction is mediated by the 'calcium-dependent protein kinase C activity' of 'Activated Ca++ and DAG dependent PKC'.

Evidence1013
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10194441
comment: At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'Platelet SEC1 protein' are present. At the end of this reaction, 1 molecule of 'Phosphorylated platelet SEC1 protein', and 1 molecule of 'ADP' are present. This reaction is mediated by the 'calcium-dependent protein kinase C activity' of 'Activated Ca++ and DAG dependent PKC'.

Evidence1012
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9601053
xref: http://identifiers.org/pubmed/19033211
xref: PublicationXref1846
xref: http://identifiers.org/pubmed/9814702
comment: The conventional Protein Kinase C (cPKC) isoforms have two membrane-targetting domains, a C1 domain which binds to the membrane lipid diacylglycerol (DAG) and a C2 domain which binds membrane phospholipids such as phosphatidylserine, in a calcium-dependent manner. Association of both domains with the plasma membrane produces a conformational change that releases an autoinhibitory pseudosubstrate segment from the substrate-binding cavity, allowing substrate binding and downstream signaling.

Evidence1011
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9601053
xref: http://identifiers.org/pubmed/17157506
comment: Hydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into the cytosol, but as DAG is a hydrophobic lipid it remains within the plasma membrane. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, while DAG activates the conventional and unconventional protein kinase C (PKC) isoforms, facilitating the translocation of PKC from the cytosol to the plasma membrane. The effects of DAG are mimicked by tumor-promoting phorbol esters. DAG is also a precursor for the biosynthesis of prostaglandins, the endocannabinoid 2-arachidonoylglycerol and an activator of a subfamily of TRP-C (Transient Receptor Potential Canonical) cation channels 3, 6, and 7.

Evidence1018
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6457647
xref: http://identifiers.org/pubmed/14630798
comment: After Platelet activation '78 kDa glucose-regulated protein' from the endoplasmic reticulum lumen is released in to the extracellular platelet releasate.

Evidence1017
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14630798
comment: Platelet releasate contains a range of proteins that do not originate in specialized storage granules. In some cases platelet lysis may contribute to the presence of these proteins in the platelet relesate.

Evidence1016
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14630798
comment: Platelet releasate contains a range of proteins that do not originate in specialized storage granules. In some cases platelet lysis may contribute to the presence of these proteins in the platelet relesate.

Evidence1009
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16116451
xref: http://identifiers.org/pubmed/11470505
xref: http://identifiers.org/pubmed/7295321
xref: http://identifiers.org/pubmed/18096503
comment: Monoacylglycerol lipase (MAGL) is a key enzyme in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol to arachidonate and glycerol. In adipocytes MAGL and hormone-sensitive lipase (LIPE) hydrolyze intracellular triglyceride stores. MAGL may also complement lipoprotein lipase (LPL) in completing hydrolysis of monoglycerides resulting from degradation of lipoprotein triglycerides.

Evidence1008
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9601053
xref: http://identifiers.org/pubmed/19033211
xref: PublicationXref1846
comment: Activation of the novel Protein Kinase C (nPKC) isoforms (delta, epsilon, eta and theta) requires binding to the membrane lipid diacylglycerol (DAG). nPKC activation is sensitive to DAG concentration.

Evidence1005
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9438848
comment: Vav interacts directly with PIP2 and PIP3, with a fivefold selectivity for PIP3 over PIP2. PIP3 gives a twofold stimulation of Vav1 GEF activity while PIP2 leads to 90% inhibition. Binding probably occurs through the PH domain, known to bind phosphoinositides.

Evidence1004
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9032261
xref: http://identifiers.org/pubmed/18589439
xref: http://identifiers.org/pubmed/15886116
xref: http://identifiers.org/pubmed/8990121
comment: Vav3 is a guanine nucleotide exchange factors (GEF) for RhoA, RhoB and to a lesser extent Rac1.

Evidence1007
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17127307
xref: http://identifiers.org/pubmed/11943772
xref: http://identifiers.org/pubmed/12649139
xref: http://identifiers.org/pubmed/16102042
comment: The GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate platelet activation through phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) in the FcR gamma chain, leading to binding and activation of the tyrosine kinase Syk. Downstream of Syk, a series of adapter molecules and effectors lead to platelet activation. The GPVI receptor signaling cascade is similar to that of T- and B-cell immune receptors, involving the formation of a signalosome composed of adapter and effector proteins. At the core of the T-cell receptor signalosome is the transmembrane adapter LAT and two cytosolic adapters SLP-76 and Gads. While LAT is essential for signalling to PLCgamma1 downstream of the T-cell receptor, the absence of LAT in platelets only impairs the activation of PLCgamma2, the response to collagen and GPVI receptor ligands remains sufficient to elicit a full aggregation response. In contrast, GPVI signalling is almost entirely abolished in the absence of SLP-76.

Evidence1006
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9438848
comment: Vav interacts directly with PIP2 and PIP3, with a fivefold selectivity for PIP3 over PIP2. PIP3 gives a twofold stimulation of Vav1 GEF activity while PIP2 leads to 90% inhibition. Binding probably occurs through the PH domain, known to bind phosphoinositides.

Evidence1001
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16319917
xref: http://identifiers.org/pubmed/12881475
xref: http://identifiers.org/pubmed/18327704
comment: Nitric Oxide (NO) inhibits smooth muscle cell proliferation and migration, oxidation of low-density lipoproteins, and platelet aggregation and adhesion. It can stimulate vasodilatation of the endothelium, disaggregation of Â preformed platelet aggregates and inhibits activated platelet recruitment to the aggregate. NO is synthesized from L-arginine by a family of isoformic enzymes known as nitric oxide synthase (NOS). Three isoforms, namely endothelial, neuronal, and inducible NOS (eNOS, nNOS, and iNOS, respectively), have been identified. The eNOS isoform is found in the endothelium and platelets. NO regulation of cyclic guanosine-3,5-monophosphate (cGMP), via activation of soluble guanylate cyclase, is the principal mechanism of negative control over platelet activity. Defects in this control mechanism have been associated with platelet hyperaggregability and associated thrombosis.

Synthesis of PIPs at the ER membrane
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction321
pathway component: BiochemicalReaction322
evidence: Evidence521
xref: UnificationXref4298
xref: UnificationXref4297
xref: RelationshipXref405
pathway order: PathwayStep517
pathway order: PathwayStep518
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence1000
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10318772
xref: http://identifiers.org/pubmed/9722588
xref: http://identifiers.org/pubmed/10605732
xref: http://identifiers.org/pubmed/11522789
xref: http://identifiers.org/pubmed/2545495
xref: http://identifiers.org/pubmed/2154470
xref: http://identifiers.org/pubmed/14597579
xref: http://identifiers.org/pubmed/12526795
xref: http://identifiers.org/pubmed/7913615
comment: Cyclic guanosine monophosphate (cGMP) is an important secondary messenger synthesized by guanylate cyclases. cGMP has effects on phosphodiesterases (PDE), ion-gated channels, and the cGMP-dependent protein kinases (cGK, Protein Kinase G or PKG). It is involved in regulation of several physiological functions including vasodilation, platelet aggregation and neurotransmission. Elevation of intracellular cGMP activates PKG (Haslam et al. 1999) which regulates several intracellular molecules and pathways including the vasodilator-stimulated phosphoprotein (VASP) (Halbrugge et al. 1990) and the ERK pathway (Hood and Granger 1998, Li et al. 2001). cGMP mediates nitric oxide (NO)-induced vascular smooth muscle relaxation (Furchgott and Vanhoutte 1989). Phosphodiesterase 5 (PDE5) hydrolyzes cGMP; the PDE5 inhibitor sildenafil (Viagra) increases intracellular cGMP and thereby can be used as a treatment for erectile dysfunction (Corbin and Francis 1999). The role of the cGMP and PKG in platelet activation was controversial as increases in platelet cGMP levels were observed in response to both platelet agonists (thrombin, ADP or collagen) and inhibitors (NO donors such as sodium nitroprusside), but it is currently accepted that PKG inhibits platelet activation (Haslam et al. 1999). Consistent with this, nitric oxide (NO) donors that inhibit platelet activation enhance intracellular cGMP (Haslam et al. 1999). cGMP also plays an important stimulatory role in GPIb-IX-mediated platelet activation. Platelet responses to cGMP have been proposed to be biphasic, consisting of an early stimulatory response that promotes platelet activation followed by a delayed platelet inhibition that serves to limit the size of platelet aggregates (Li et al 2003).

Evidence1003
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9032261
xref: http://identifiers.org/pubmed/18589439
xref: http://identifiers.org/pubmed/15886116
xref: http://identifiers.org/pubmed/8990121
comment: Members of the Vav family are guanine nucleotide exchange factors (GEFs) for Rho-family GTPases. Vav2 is a GEF for RhoA, RhoB and RhoG, and possibly Rac1 and Cdc42

Evidence1002
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10798271
xref: http://identifiers.org/pubmed/16297879
xref: PublicationXref1835
comment: Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in character. Under acute vascular trauma, vasoconstrictor mechanisms predominate and the endothelium becomes prothrombotic, procoagulatory and proinflammatory in nature. This is achieved by a reduction of endothelial dilating agents: adenosine, NO and prostacyclin; and by the direct action of ADP, serotonin and thromboxane on vascular smooth muscle cells to elicit their contraction (Becker et al. 2000). Cyclooxygenase-2 (COX-2) and endothelial nitric oxide synthase (eNOS) are primarily expressed in endothelial cells. Both are important regulators of vascular function. Under normal conditions, laminar flow induces vascular endothelial COX-2 expression and synthesis of Prostacyclin (PGI2) which in turn stimulates endothelial Nitric Oxide Synthase (eNOS) activity. PGI2 and NO both oppose platelet activation and aggregation, as does the CD39 ecto-ADPase, which decreases platelet activation and recruitment by metabolizing platelet-released ADP.

RNA Polymerase II Transcription Elongation
type: Pathway
data source: Provenance1
pathway component: REACT 99528.9
evidence: Evidence922
xref: UnificationXref7250
xref: RelationshipXref896
xref: UnificationXref7251
pathway order: PathwayStep933
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/19935667
type: PublicationXref
id: 19935667
author: Hall, RA
author: Ritter, SL
db: Pubmed
title: Fine-tuning of GPCR activity by receptor-interacting proteins
source: Nat Rev Mol Cell Biol 10:819-30
year: 2009

http://identifiers.org/pubmed/11988738
type: PublicationXref
id: 11988738
author: Lukas, J
author: Jackson, PK
author: Reimann, JD
author: Sorensen, CS
author: Hsu, JY
db: Pubmed
title: E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
source: Nat Cell Biol 4:358-66
year: 2002

UniProt:Q00684
type: ProteinReference
xref: UnificationXref1330
organism: BioSource1

NRAGE signals death through JNK
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction728
evidence: Evidence1136
xref: UnificationXref8531
xref: UnificationXref8530
xref: RelationshipXref1049
pathway order: PathwayStep1142
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/19006241
type: PublicationXref
id: 19006241
author: Häberle, J
author: Höhne, W
author: Engel, K
db: Pubmed
title: Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene
source: Hum Mutat 30:300-7
year: 2009

http://identifiers.org/pubmed/10590411
type: PublicationXref
id: 10590411
author: Foellmer, JW
author: Davis, JI
author: Merezhinskaya, N
author: Fishbein, WN
db: Pubmed
title: Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport
source: Muscle Nerve 23:90-7
year: 2000

Extension of Telomeres
type: Pathway
data source: Provenance1
pathway component: REACT 106277.9
pathway component: REACT 85706.9
evidence: Evidence152
xref: UnificationXref1397
xref: UnificationXref1396
pathway order: PathwayStep156
pathway order: PathwayStep148
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

CaM pathway
type: Pathway
data source: Provenance1
pathway component: REACT 110818.9
evidence: Evidence188
xref: UnificationXref2034
xref: UnificationXref2033
pathway order: PathwayStep189
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8499
type: UnificationXref
id: REACT_141632
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141632.5

UnificationXref8497
type: UnificationXref
id: REACT_114614
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114614.8

UnificationXref8498
type: UnificationXref
id: 3673368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673368

http://identifiers.org/pubmed/16413920
type: PublicationXref
id: 16413920
author: Nimmerjahn, F
author: Ravetch, JV
db: Pubmed
title: Fcgamma receptors: old friends and new family members
source: Immunity 24:19-28
year: 2006

UnificationXref8479
type: UnificationXref
id: 3668832
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668832

UnificationXref8476
type: UnificationXref
id: 3668823
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668823

UnificationXref8475
type: UnificationXref
id: 3668822
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668822

Evidence1099
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19096775
xref: http://identifiers.org/pubmed/18566824
xref: http://identifiers.org/pubmed/11773613
xref: http://identifiers.org/pubmed/17222168
xref: http://identifiers.org/pubmed/15924268
comment: In the kidney water and solutes are passed out of the bloodstream and into the proximal tubule via the slit-like structure formed by nephrin in the glomerulus. Water is reabsorbed from the filtrate during its transit through the proximal tubule, the descending loop of Henle, the distal convoluted tubule, and the collecting duct. Aquaporin-1 (AQP1) in the proximal tubule and the descending thin limb of Henle is responsible for about 90% of reabsorption (as estimated from mouse knockouts of AQP1). AQP1 is located on both the apical and basolateral surface of epithelial cells and thus transports water through the epithelium and back into the bloodstream. In the collecting duct epithelial cells have AQP2 on their apical surface and AQP3 and AQP4 on their basolateral surface to transport water across the epithelium. The permeability of the epithelium is regulated by vasopressin, which activates the phosphorylation and subsequent translocation of AQP2 from intracellular vesicles to the plasma membrane.

UnificationXref8478
type: UnificationXref
id: 3668831
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668831

UnificationXref8477
type: UnificationXref
id: P41318
db: UniProt

UnificationXref8482
type: UnificationXref
id: P38070
db: UniProt

Evidence1095
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18678926
xref: http://identifiers.org/pubmed/10564231
xref: http://identifiers.org/pubmed/18762715
xref: http://identifiers.org/pubmed/19590626
xref: http://identifiers.org/pubmed/11027599
xref: http://identifiers.org/pubmed/12084581
xref: http://identifiers.org/pubmed/11573934
comment: Aquaporin-9 (AQP9) and AQP10 are 6-pass transmembrane proteins that passively transport urea across the plasma membrane through a pore in each subunit of a homotetramer.

UnificationXref8483
type: UnificationXref
id: 3668837
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668837

Evidence1096
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10564231
xref: http://identifiers.org/pubmed/18762715
xref: http://identifiers.org/pubmed/19590626
xref: http://identifiers.org/pubmed/11027599
xref: http://identifiers.org/pubmed/12084581
xref: http://identifiers.org/pubmed/11573934
comment: Aquaporin-9 (AQP9) and AQP10 are 6-pass transmembrane proteins that passively transport urea across the plasma membrane through a pore in each subunit of a homotetramer.

UnificationXref8484
type: UnificationXref
id: 3668840
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668840

Evidence1097
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19448080
xref: http://identifiers.org/pubmed/17513417
xref: http://identifiers.org/pubmed/18173545
xref: http://identifiers.org/pubmed/16764946
xref: http://identifiers.org/pubmed/11773613
xref: http://identifiers.org/pubmed/15340377
xref: http://identifiers.org/pubmed/17961083
xref: http://identifiers.org/pubmed/19096775
xref: http://identifiers.org/pubmed/18566824
xref: http://identifiers.org/pubmed/15901243
xref: http://identifiers.org/pubmed/19096781
xref: http://identifiers.org/pubmed/19096770
xref: http://identifiers.org/pubmed/15924268
xref: http://identifiers.org/pubmed/17222168
comment: Aquaporins (AQP's) are six-pass transmembrane proteins that form channels in membranes. Each monomer contains a central channel formed in part by two asparagine-proline-alanine motifs (NPA boxes) that confer selectivity for water and/or solutes. The monomers assemble into tetramers. Most aquaporins (i.e. AQP0/MIP, AQP1, AQP2, AQP3, AQP4, AQP5, AQP7, AQP8, AQP9, AQP10) passively transport water into and out of cells according to the osmotic gradient across the membrane. Four aquaporins (the aquaglyceroporins AQP3, AQP7, AQP9, AQP10) conduct glycerol, three aquaporins (AQP7, AQP9, AQP10) conduct urea, and one aquaporin (AQP6) conducts anions, especially nitrate. AQP8 also conducts ammonia in addition to water. AQP11 and AQP12, classified as group III aquaporins, were identified as a result of the genome sequencing project and are characterized by having variations in the first NPA box when compared to more traditional aquaporins. Additionally, a conserved cysteine residue is present about 9 amino acids downstream from the second NPA box and this cysteine is considered indicative of group III aquaporins. Purified AQP11 incorporated into liposomes showed water transport. Knockout mice lacking AQP11 had fatal cyst formation in the proximal tubule of the kidney. Exogenously expressed AQP12 showed intracellular localization. AQP12 is expressed exclusively in pancreatic acinar cells. Aquaporins are important in fluid and solute transport in various tissues. In adipocytes, glycerol generated by triglyceride hydrolysis is exported by AQP7 and is imported by liver cells via AQP9. AQP1 plays a role in forming cerebrospinal fluid and AQP1, AQP4, and AQP9 appear to be important in maintaining fluid balance in the brain. AQP0, AQP1, AQP3, AQP4, AQP8, AQP9, and AQP11 play roles in the physiology of the hepatobiliary tract. In the kidney, water and solutes are passed out of the bloodstream and into the proximal tubule via the slit-like structure formed by nephrin in the glomerulus. …

UnificationXref8485
type: UnificationXref
id: 3668845
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668845

Evidence1098
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9374640
xref: http://identifiers.org/pubmed/18678926
xref: http://identifiers.org/pubmed/7538665
xref: http://identifiers.org/pubmed/7503232
xref: http://identifiers.org/pubmed/9374639
xref: http://identifiers.org/pubmed/15703994
xref: http://identifiers.org/pubmed/8063828
xref: http://identifiers.org/pubmed/9369468
xref: http://identifiers.org/pubmed/7526388
comment: Aquaporin-3 (AQP3) passively transports water and glycerol across the plasma membrane according to the osmotic gradient. AQP3 is expressed in airway epithelia, secretory glands, skin, the collecting ducts of the kidney, and the basolateral surface of intestinal epithelium..

Evidence1091
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7510718
xref: http://identifiers.org/pubmed/17178220
xref: http://identifiers.org/pubmed/18555844
xref: http://identifiers.org/pubmed/9806845
xref: http://identifiers.org/pubmed/11034202
xref: http://identifiers.org/pubmed/16596446
xref: http://identifiers.org/pubmed/16407156
xref: http://identifiers.org/pubmed/15703994
xref: http://identifiers.org/pubmed/18501347
xref: http://identifiers.org/pubmed/7535000
xref: http://identifiers.org/pubmed/1510932
xref: http://identifiers.org/pubmed/11952783
xref: http://identifiers.org/pubmed/18202181
xref: http://identifiers.org/pubmed/19574955
xref: http://identifiers.org/pubmed/19383790
xref: http://identifiers.org/pubmed/1373524
xref: http://identifiers.org/pubmed/15948717
xref: http://identifiers.org/pubmed/9829975
xref: http://identifiers.org/pubmed/3049610
xref: http://identifiers.org/pubmed/10564231
xref: http://identifiers.org/pubmed/14701836
xref: http://identifiers.org/pubmed/19590626
xref: http://identifiers.org/pubmed/7678419
xref: http://identifiers.org/pubmed/11573934
xref: http://identifiers.org/pubmed/8140421
xref: http://identifiers.org/pubmed/19144687
xref: http://identifiers.org/pubmed/19170255
xref: http://identifiers.org/pubmed/18762715
xref: http://identifiers.org/pubmed/19857466
xref: http://identifiers.org/pubmed/10510269
xref: http://identifiers.org/pubmed/17374283
xref: http://identifiers.org/pubmed/12801959
xref: http://identifiers.org/pubmed/11001937
xref: http://identifiers.org/pubmed/7530250
xref: http://identifiers.org/pubmed/8621489
xref: http://identifiers.org/pubmed/9369468
xref: http://identifiers.org/pubmed/14592814
xref: http://identifiers.org/pubmed/18511455
xref: http://identifiers.org/pubmed/11027599
xref: http://identifiers.org/pubmed/18948439
xref: http://identifiers.org/pubmed/17920625
xref: http://identifiers.org/pubmed/11532455
xref: http://identifiers.org/pubmed/18678926
xref: http://identifiers.org/pubmed/11076974
xref: http://identifiers.org/pubmed/16325777
xref: http://identifiers.org/pubmed/20147624
xref: http://identifiers.org/pubmed/11231887
xref: http://identifiers.org/pubmed/8855281
xref: http://identifiers.org/pubmed/18768791
xref: http://identifiers.org/pubmed/21251984
xref: http://identifiers.org/pubmed/9405233
xref: http://identifiers.org/pubmed/14514735
xref: http://identifiers.org/pubmed/12084581
comment: Aquaporin-0 (AQP0, also known as MIP), AQP1, AQP2, AQP3, AQP4, AQP5, AQP7, AQP8, AQP9, and AQP10 are 6-pass transmembrane proteins that passively transport water across the plasma membrane according to the concentration gradient. Each molecule contains a water channel and subunits assemble into homotetramers. In principle water can move in either direction through an aquaporin, however in vivo flow may occur in only one direction. Conductance of water by AQP0 and AQP11 are low relative to other aquaporins.

Evidence1092
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7510718
xref: http://identifiers.org/pubmed/17178220
xref: http://identifiers.org/pubmed/18555844
xref: http://identifiers.org/pubmed/9806845
xref: http://identifiers.org/pubmed/11034202
xref: http://identifiers.org/pubmed/16596446
xref: http://identifiers.org/pubmed/15703994
xref: http://identifiers.org/pubmed/18501347
xref: http://identifiers.org/pubmed/7535000
xref: http://identifiers.org/pubmed/1510932
xref: http://identifiers.org/pubmed/11952783
xref: http://identifiers.org/pubmed/18202181
xref: http://identifiers.org/pubmed/1373524
xref: http://identifiers.org/pubmed/15948717
xref: http://identifiers.org/pubmed/19383790
xref: http://identifiers.org/pubmed/9829975
xref: http://identifiers.org/pubmed/3049610
xref: http://identifiers.org/pubmed/10564231
xref: http://identifiers.org/pubmed/14701836
xref: http://identifiers.org/pubmed/19590626
xref: http://identifiers.org/pubmed/7678419
xref: http://identifiers.org/pubmed/11573934
xref: http://identifiers.org/pubmed/8140421
xref: http://identifiers.org/pubmed/19144687
xref: http://identifiers.org/pubmed/19170255
xref: http://identifiers.org/pubmed/18762715
xref: http://identifiers.org/pubmed/19857466
xref: http://identifiers.org/pubmed/10510269
xref: http://identifiers.org/pubmed/17374283
xref: http://identifiers.org/pubmed/12801959
xref: http://identifiers.org/pubmed/11001937
xref: http://identifiers.org/pubmed/7530250
xref: http://identifiers.org/pubmed/8621489
xref: http://identifiers.org/pubmed/9369468
xref: http://identifiers.org/pubmed/14592814
xref: http://identifiers.org/pubmed/18511455
xref: http://identifiers.org/pubmed/11027599
xref: http://identifiers.org/pubmed/18948439
xref: http://identifiers.org/pubmed/17920625
xref: http://identifiers.org/pubmed/11532455
xref: http://identifiers.org/pubmed/18678926
xref: http://identifiers.org/pubmed/11076974
xref: http://identifiers.org/pubmed/16325777
xref: http://identifiers.org/pubmed/20147624
xref: http://identifiers.org/pubmed/11231887
xref: http://identifiers.org/pubmed/8855281
xref: http://identifiers.org/pubmed/18768791
xref: http://identifiers.org/pubmed/21251984
xref: http://identifiers.org/pubmed/9405233
xref: http://identifiers.org/pubmed/14514735
xref: http://identifiers.org/pubmed/12084581
comment: Aquaporin-0 (AQP0, also known as MIP), AQP1, AQP2, AQP3, AQP4, AQP5, AQP7, AQP8, AQP9, and AQP10 are 6-pass transmembrane proteins that passively transport water across the plasma membrane according to the concentration gradient. Each molecule contains a water channel and subunits assemble into homotetramers. In principle water can move in either direction through an aquaporin, however in vivo flow may occur in only one direction. Conductance of water by AQP0 and AQP11 are low relative to other aquaporins.

UnificationXref8480
type: UnificationXref
id: 3668833
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668833

Evidence1093
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18678926
xref: http://identifiers.org/pubmed/10564231
xref: http://identifiers.org/pubmed/10510269
xref: http://identifiers.org/pubmed/16325777
xref: http://identifiers.org/pubmed/18555844
xref: http://identifiers.org/pubmed/16596446
xref: http://identifiers.org/pubmed/19590626
xref: http://identifiers.org/pubmed/9369468
xref: http://identifiers.org/pubmed/11952783
xref: http://identifiers.org/pubmed/11573934
xref: http://identifiers.org/pubmed/18762715
xref: http://identifiers.org/pubmed/9405233
xref: http://identifiers.org/pubmed/11027599
xref: http://identifiers.org/pubmed/12084581
comment: Aquaporin-3 (AQP3), AQP7, AQP9, and AQP10 are 6-pass transmembrane proteins that passively transport glycerol across the plasma membrane through a pore in each subunit of a homotetramer.

UnificationXref8481
type: UnificationXref
id: REACT_105021
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105021.9

Evidence1094
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18678926
xref: http://identifiers.org/pubmed/10564231
xref: http://identifiers.org/pubmed/10510269
xref: http://identifiers.org/pubmed/16325777
xref: http://identifiers.org/pubmed/18555844
xref: http://identifiers.org/pubmed/16596446
xref: http://identifiers.org/pubmed/19590626
xref: http://identifiers.org/pubmed/9369468
xref: http://identifiers.org/pubmed/11952783
xref: http://identifiers.org/pubmed/11573934
xref: http://identifiers.org/pubmed/18762715
xref: http://identifiers.org/pubmed/9405233
xref: http://identifiers.org/pubmed/11027599
xref: http://identifiers.org/pubmed/12084581
comment: Aquaporin-3 (AQP3), AQP7, AQP9, and AQP10 are 6-pass transmembrane proteins that passively transport glycerol across the plasma membrane through a pore in each subunit of a homotetramer.

Evidence1090
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19164095
xref: http://identifiers.org/pubmed/14624363
comment: Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates (ions or water) down their electrochemical gradient, at an extremely high efficiency (up to 108 s-1). Transporters facilitate the movement of a specific substrate âeither against or following their concentration gradient, at a lower speed (about 102 -104 s-1); as generally believed, conformational change of the transporter protein is involved in the transfer process. According to the Human Genome Organization (HUGO) Gene Nomenclature Committee, all human transporters can be grouped into the solute-carrier (SLC) superfamily. Currently, there are 55 SLC families in the superfamily, with a total of at least 362 putatively functional protein-coding genes (Hediger et al, 2004; He et al., 2009). At least 20-25% amino-acid sequence identity is shared by members belonging to the same SLC family. No homology is shared between different SLC families. While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lower cases letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene). And it's worthwhile to mention that pumps, channels and aquporins are not included in SLC superfamily.

http://identifiers.org/pubmed/11779870
type: PublicationXref
id: 11779870
author: Tsurumi, T
author: Fujita, M
author: Kiyono, T
author: Nakamura, H
author: Ishimi, Y
db: Pubmed
title: Nuclear organization of DNA replication initiation proteins in mammalian cells.
source: J Biol Chem 277:10354-61
year: 2002

http://identifiers.org/pubmed/12205100
type: PublicationXref
id: 12205100
author: Van Komen, S
author: Sigurdsson, S
author: Petukhova, G
author: Sung, P
db: Pubmed
title: Homologous DNA pairing by human recombination factors Rad51 and Rad54
source: J Biol Chem 277:42790-4
year: 2002

http://identifiers.org/pubmed/9564029
type: PublicationXref
id: 9564029
author: Kushner, JP
author: Phillips, JD
author: Hill, CP
author: Whitby, FG
db: Pubmed
title: Crystal structure of human uroporphyrinogen decarboxylase
source: EMBO J 17:2463-71
year: 1998

http://identifiers.org/pubmed/3413114
type: PublicationXref
id: 3413114
author: Cram, LS
author: Wu, JR
author: Ratliff, RL
author: Buckingham, JM
author: Moyzis, RK
author: Jones, MD
author: Meyne, J
author: Deaven, LL
author: Dani, M
db: Pubmed
title: A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
source: Proc Natl Acad Sci U S A 85:6622-6
year: 1988

http://identifiers.org/pubmed/2905684
type: PublicationXref
id: 2905684
author: Sturm, RA
author: Herr, W
author: Das, G
db: Pubmed
title: The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain
source: Genes Dev 2:1582-99
year: 1988

http://identifiers.org/pubmed/11130078
type: PublicationXref
id: 11130078
author: Sato, S
author: Takeda, K
author: Wagner, H
author: Sanjo, H
author: Takeuchi, O
author: Hoshino, K
author: Matsumoto, M
author: Kaisho, T
author: Kawai, T
author: Hemmi, H
author: Akira, S
db: Pubmed
title: A Toll-like receptor recognizes bacterial DNA
source: Nature 408:740-5
year: 2000

UnificationXref8489
type: UnificationXref
id: 3668852
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668852

UnificationXref8488
type: UnificationXref
id: 3668844
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668844

UnificationXref8487
type: UnificationXref
id: 3668846
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668846

UnificationXref8486
type: UnificationXref
id: REACT_113269
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113269.8

UnificationXref8495
type: UnificationXref
id: REACT_112856
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112856.8

UnificationXref8496
type: UnificationXref
id: 3673367
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673367

UnificationXref8493
type: UnificationXref
id: REACT_99918
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99918.9

UnificationXref8494
type: UnificationXref
id: 3673369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673369

UnificationXref8491
type: UnificationXref
id: 3668859
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668859

UnificationXref8492
type: UnificationXref
id: 3668861
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668861

UnificationXref8490
type: UnificationXref
id: 3668858
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668858

UnificationXref8454
type: UnificationXref
id: 3673554
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673554

Evidence1078
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8986748
comment: The plasma membrane-associated protein SLC29A1 mediates the reversible transport of one molecule of adenosine, guanosine, inosine, or uridine from the cytosol to the extracellular space.

UnificationXref8453
type: UnificationXref
id: REACT_141321
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141321.5

Evidence1077
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9478986
comment: The plasma membrane-associated protein SLC29A2 mediates the reversible transport of one molecule of adenine, adenosine, cytidine, cytosine, guanine, guanosine, hypoxanthine, inosine, thymidine, thymine, uracil, or uridine from the cytosol to the extracellular space.

UnificationXref8456
type: UnificationXref
id: 3673100
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673100

UnificationXref8455
type: UnificationXref
id: REACT_129256
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129256.5

Evidence1079
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9478986
comment: The plasma membrane-associated protein SLC29A2 mediates the reversible transport of one molecule of adenine, adenosine, cytidine, cytosine, guanine, guanosine, hypoxanthine, inosine, thymidine, thymine, uracil, or uridine from the extracellular space to the cytosol.

UnificationXref8458
type: UnificationXref
id: 3673223
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673223

UnificationXref8457
type: UnificationXref
id: REACT_32055
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32055.10

FCERI mediated MAPK activation
type: Pathway
data source: Provenance1
pathway component: REACT 107261.9
pathway component: BiochemicalReaction683
pathway component: BiochemicalReaction684
evidence: Evidence1344
xref: UnificationXref9319
xref: UnificationXref9320
pathway order: PathwayStep200
pathway order: PathwayStep1045
pathway order: PathwayStep1046
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8459
type: UnificationXref
id: REACT_137111
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137111.5

Evidence1070
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12446736
comment: The human gene SLC30A7 encodes the zinc transporter ZnT7. It is thought to be present in the small intestine and lung in humans (Kirschke CP and Huang L, 2003). Functional properties assigned to ZnT7 are based on studies conducted with mouse experiments.

Evidence1071
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12748859
comment: The human SLC30 gene family of solute carriers is thought to participate in the homeostasis of zinc ions and facilitate zinc transport into specialized compartments of the cell such as endosomes, golgi network and synaptic vesicles. There are 10 members of this family, named ZnT1-10. ZnT4, ZnT9 and ZnT10 have no function determined as of yet (Palmiter RD and Huang L, 2004).

Evidence1072
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16675045
xref: http://identifiers.org/pubmed/18754861
xref: http://identifiers.org/pubmed/17374385
comment: Zinc is an essential element for all organisms because it serves as a catalytic or structural cofactor for many different proteins. Cellular zinc homoeostasis is co-ordinated through Zn2+-specific transporters which are members of two distinct gene families. Members of the SLC39 gene family (ZRTL-like import proteins1â14, ZIP1-14) are responsible for Zn2+ import into the cytoplasm, either across the plasma membrane or out of intracellular organelles. In contrast, members of the SLC30 gene family (zinc transporters 1â10, ZnT1-10) export Zn2+ from the cytoplasm, either across the plasma membrane into the extracellular space or into intracellular organelles (Murakami M and Hirano T, 2008; Devirgiliis C et al, 2007; Eide DJ, 2006)

UnificationXref8460
type: UnificationXref
id: 3673224
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673224

Evidence1073
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11734551
xref: http://identifiers.org/pubmed/17211682
xref: http://identifiers.org/pubmed/9207117
comment: Copper (Cu2+) is essential for many important biological processes such as mitochondrial oxidative phosphorylation, detoxification of free radicals, iron metabolism and neurotransmiter synthesis. Too much influx results in cell poisoning. In humans, there are two member of the SLC31 gene family that are implicated in copper transport. The human gene SLC31A1 encodes human copper transporter 1, hCTR1 and is ubiquitiously expressed, with highest levels seen in the liver.. It was first identified by functional complementation in ctr1-deficient yeast (Zhou B and Gitschier J, 1997). hCTR1 exists as a homotrimer at the plasma membrane of cells (De Feo CJ et al, 2007) and is responsible for high-affinity copper uptake (Lee J et al, 2002). The second gene product, hCTR2, has not be characterized yet.

UnificationXref8461
type: UnificationXref
id: REACT_120625
db: Reactome
id version: 6
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120625.6

Evidence1074
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16675045
xref: http://identifiers.org/pubmed/19164095
xref: http://identifiers.org/pubmed/17374385
xref: http://identifiers.org/pubmed/12827356
xref: http://identifiers.org/pubmed/16908340
xref: http://identifiers.org/pubmed/16825786
xref: http://identifiers.org/pubmed/17215883
xref: http://identifiers.org/pubmed/16720382
xref: http://identifiers.org/pubmed/17439925
xref: http://identifiers.org/pubmed/15157936
xref: http://identifiers.org/pubmed/12748861
xref: http://identifiers.org/pubmed/14530973
xref: http://identifiers.org/pubmed/12836025
comment: Six SLC gene families encode proteins which mediate transport of metals. The families are SLC11, SLC30, SLC31, SLC39, SLC40 and SLC41 (He L et al, 2009; Bressler JP et al, 2007).

UnificationXref8462
type: UnificationXref
id: 3673348
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673348

Evidence1075
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12750891
xref: http://identifiers.org/pubmed/12811562
xref: http://identifiers.org/pubmed/12748858
xref: http://identifiers.org/pubmed/19164095
comment: Hexoses like glucose, galactose and fructose serve as basic fuel molecules for eukaryotic cells. Indeed, glucose is the main energy source for mammalian cells. These sugars are unable to diffuse across cellular membranes, and require transporter proteins for entry into and exit out of cells. Four gene families encode hexose transporter proteins (He et al, 2009). SLC2 family contains 14 genes and encode facilitative glucose transporters (GLUTs) (Uldry M and Thorens B, 2004). SLC5 family contains 12 genes and encode Na+/glucose symporters (Wright EM and Turk E, 2004). SLC37 family contains 4 members and encode sugar-phosphate/phosphate exchangers (Bartoloni L and Antonarakis SE, 2004). SLC45 family has 4 members and encode putative sugar/H+ symporters.

UnificationXref8463
type: UnificationXref
id: REACT_156712
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156712.3

Evidence1076
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8986748
comment: The plasma membrane-associated protein SLC29A1 mediates the reversible transport of one molecule of adenosine, cytosine, guanosine, inosine, thymidine, or uridine from the extracellular space to the cytosol.

UnificationXref8467
type: UnificationXref
id: 3668813
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668813

UnificationXref8466
type: UnificationXref
id: 3668812
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668812

UnificationXref8465
type: UnificationXref
id: 3668811
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668811

Evidence1089
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: This pathway groups the processes mediated by SLC transporters, by which vitamins and cofactors, as well as nucleosides, nucleotides, nucleobases, and related molecules cross lipid bilayer membranes.

UnificationXref8464
type: UnificationXref
id: P25378
db: UniProt

Evidence1088
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17495600
xref: http://identifiers.org/pubmed/12856180
comment: Long chain fatty acids (LCFAs) are involved in many cellular functions. They can be used as an important source of energy by skeletal muscle and heart tissues. Also, they are used in the production of hormones which can regulate inflammation, blood pressure, the clotting process, blood lipid levels and the immune response. Fatty acid transporter proteins (FATPs) are a family of proteins which mediate fatty acid uptake into cells when overexpressed. FATPs also possess enzymatic activity, the details of which are captured elsewhere. There are 6 human genes of the SLC27A family which encode for FATP1-6 (Stahl A, 2004; Gimeno RE, 2007). To date, only FATP1, 4 and 6 have demonstrable transporter function. Fatty acids with carbon chain lengths of more than 10 are the most likely substrates for these transporters.

(R)-2-hydroxyglutaric acid
type: SmallMoleculeReference
name: (R)-2-Hydroxyglutarate
name: ChEBI:32796 (R)-2-hydroxyglutaric acid
xref: UnificationXref4932

UnificationXref8469
type: UnificationXref
id: REACT_87582
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87582.9

Molybdenum cofactor biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction481
evidence: Evidence734
xref: RelationshipXref699
xref: UnificationXref5767
xref: UnificationXref5766
pathway order: PathwayStep735
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8468
type: UnificationXref
id: 3668814
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668814

Evidence1082
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12110519
xref: http://identifiers.org/pubmed/9124315
xref: http://identifiers.org/pubmed/12527552
xref: http://identifiers.org/pubmed/11032837
xref: http://identifiers.org/pubmed/10455109
xref: http://identifiers.org/pubmed/9435697
xref: http://identifiers.org/pubmed/12838422
xref: http://identifiers.org/pubmed/12856181
comment: Two families of transport proteins mediate the movement of nucleosides and free purine and pyrimidine bases across the plasma membrane. Equilibrative nucleoside transporters allow the movement of these molecules along concentration gradients into or out of cells (Baldwin et al. 2003); concentrative nucleoside transporters actively transport nucleosides into cells by coupling their transport to the inward movement of sodium ions (Gray et al. 2003). Of the four human equilibrative nucleoside transporters, two are well characterized. SLC29A1 (solute carrier family 29 (nucleoside transporters), member 1) mediates the transport of nucleosides across the plasma membrane. SLC29A2 (solute carrier family 29 (nucleoside transporters), member 2) mediates the transport of both nucleosides and free bases. Transporter specificities were determined by expressing cloned human genes in Xenopus oocytes or in mammalian cultured cell lines whose own nucleotide transporters had been disrupted by mutation. These studies establish that the transport processes are specific and saturable, and that the multiple nucleotides and bases compete for a single binding site on each transporter. Some features of SLC29A2 specificity are complex. For example, in the Xenopus oocyte system, radiolabeled uracil and adenine are taken up, and an excess of either molecule inhibits uptake of radiolabeled hypoxanthine, while in the cultured mammalian cell system, neither adenine nor uracil can inhibit uptake of radiolabeled uridine. If these results reflect ENT2 function in vivo, they indicate that the net movement of a nucleoside or base across the cell membrane is determined not only by its own concentrations in the extracellular space and the cytosol, but also by the concentrations of the other nucleosides and bases competing for access to the transporter. The human genome encodes three concentrative transporters, SLC28A1, 2, and 3 (solute carrier family 28 (sodium-coupled nucleoside transporter), member 1,…

UnificationXref8470
type: UnificationXref
id: P38873
db: UniProt

Evidence1083
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19061983
xref: http://identifiers.org/pubmed/9096318
comment: The human gene SLC33A1 encodes acetyl-CoA transporter AT1 (Kanamori A et al, 1997).Acetyl-CoA is transported to the lumen of the Golgi apparatus, where it serves as the substrate of acetyltransferases that modify the sialyl residues of gangliosides and glycoproteins. Defects in SLC33A1 are the cause of spastic paraplegia autosomal dominant type 42 (SPG42) which is a neurodegenerative disorder (Lin P et al, 2008).

http://identifiers.org/pubmed/3208766
type: PublicationXref
id: 3208766
author: Day, IN
author: Fothergill, JE
author: McAleese, SM
author: Hinks, LJ
author: Dunbar, B
db: Pubmed
title: Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE)
source: Eur J Biochem 178:413-7
year: 1988

Evidence1080
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15701636
xref: http://identifiers.org/pubmed/18940313
comment: The human gene SLC29A3 encodes the equilibrative nucleoside transporter 3 (ENT3). It is abundant in many tissues, especially the placenta and is localized intracellularly on the lysosomal membrane. ENT3 mediates the reversible transport of nucleosides and the nucleobase adenine (Baldwin SA et al, 2005). Defects in SLC29A3 are the cause of H syndrome, an autosomal recessive disorder(Molho-Pessach V et al, 2008).

Evidence1081
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15701636
comment: The human gene SLC29A3 encodes the equilibrative nucleoside transporter 3 (ENT3). It is abundant in many tissues, especially the placenta and is localized intracellularly on the lysosomal membrane. ENT3 mediates the reversible transport of nucleosides and the nucleobase adenine (Baldwin SA et al, 2005). Defects in SLC29A3 are the cause of H syndrome, an autosomal recessive disorder(Molho-Pessach V et al, 2008).

UnificationXref8473
type: UnificationXref
id: 3668818
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668818

Evidence1086
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12759756
xref: http://identifiers.org/pubmed/16981043
xref: http://identifiers.org/pubmed/19164095
comment: Nucleotide sugars are used as sugar donors by glycosyltransferases to create the sugar chains for glycoconjugates such as glycoproteins, polysaccharides and glycolipids. Glycosyltransferases reside mainly in the lumen of the Golgi apparatus and endoplasmic reticulum (ER) whereas nucleotide sugars are synthesized in the cytosol. The human solute carrier family SLC35 encode nucleotide sugar transporters (NSTs) which can mediate the antiport of nucleotide sugars in exchange for the corresponding nucleoside monophosphates (eg. UMP for UDP-sugars). Owing to their function, NSTs are primarily located on Golgi and ER membranes (He L et al, 2009; Handford M et al, 2006; Ishida N and Kawakita M, 2004).

UnificationXref8474
type: UnificationXref
id: P32600
db: UniProt

Evidence1087
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12235169
xref: http://identifiers.org/pubmed/12556534
xref: http://identifiers.org/pubmed/9878842
xref: http://identifiers.org/pubmed/10518211
comment: Of the six fatty acid transporter proteins (FATP) characterized, only three have been shown to mediate the influx into cells of long chain fatty acids (LCFAs); FATP1, 4 and 6. They have been shown to transport the prototypical LCFA oleic acid (OLEA) but are believed to be able to transport LCFAs with chain lengths longer than 10 carbons. FATP1 is highly expressed in adipose tissue and muscle (Hatch GM et al, 2002). FATP4 is the major intestinal LCFA transporter (Fitscher BA et al, 1998; Stahl A et al, 1999). FATP6 is localized to cardiac myocytes (Gimeno RE et al, 2003).

UnificationXref8471
type: UnificationXref
id: 3668827
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668827

Evidence1084
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15911612
comment: The human gene SLC35B4 encodes the bifunctional UDP-xylose and UDP-N-acetylglucosamine transporter YEA4. YEA4 resides on the Golgi membrane and mediates the influx of UDP-xylose into the lumen (Ashikov A et al, 2005).

UnificationXref8472
type: UnificationXref
id: P35169
db: UniProt

Evidence1085
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15911612
comment: The human gene SLC35B4 encodes the bifunctional UDP-xylose and UDP-N-acetylglucosamine transporter YEA4. YEA4 resides on the Golgi membrane and mediates the influx of UDP-N-acetylglucosamine into the lumen (Ashikov A et al, 2005).

http://identifiers.org/pubmed/20930137
type: PublicationXref
id: 20930137
author: Kull, FJ
author: Endow, SA
author: Liu, H
db: Pubmed
title: Kinesins at a glance
source: J Cell Sci 123:3420-4
year: 2010

UnificationXref8435
type: UnificationXref
id: 947588
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=947588

Evidence1059
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11279194
xref: http://identifiers.org/pubmed/15522866
comment: NHE7 and 8 (SLC9A7,8) (Nakamura N et al, 2005) are expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in the trans-golgi network.

UnificationXref8436
type: UnificationXref
id: REACT_26709
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26709.2

UnificationXref8437
type: UnificationXref
id: P39524
db: UniProt

UniProt:Q00711
type: ProteinReference
xref: UnificationXref4913
organism: BioSource1

UnificationXref8438
type: UnificationXref
id: 3671732
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671732

UnificationXref8431
type: UnificationXref
id: 939760
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939760

Evidence1055
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17656326
comment: Mammalian ABC transporters are usually found on the plasma membrane and on organelles such as the ER and peroxisome but a small number are also located on the mitochondria. Here they are thought to play roles in heme biosynthesis and iron-sulphur cluster synthesis (Burke & Ardehali 2007).

http://identifiers.org/pubmed/19540337
type: PublicationXref
id: 19540337
author: Masson, K
author: Rönnstrand, L
db: Pubmed
title: Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
source: Cell Signal 21:1717-26
year: 2009

UnificationXref8432
type: UnificationXref
id: REACT_26149
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26149.2

Evidence1056
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16816140
comment: The multidrug resistance associated protein (MRPs) subfamily of the ABC transporter family can transport a wide and diverse range of organic anions that can be endogenous compounds and xenobiotics and their metabolites. All human MRPs (except MRP9) can mediate these transport reactions (Deeley et al. 2006). Separately, specific reactions have also been annotated to describe the roles of ABCC4 in platelet dense granule assembly, of ABCC1 in LTC4 export (an aspect of leukotriene synthesis), and of ABCC3 in bile salt efflux.

UnificationXref8433
type: UnificationXref
id: 947592
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=947592

Evidence1057
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12045106
xref: http://identifiers.org/pubmed/15209530
xref: http://identifiers.org/pubmed/19234479
xref: http://identifiers.org/pubmed/11435397
comment: The ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes against steep concentration gradients at the cost of ATP hydrolysis. These substrates include amino acids, lipids, inorganic ions, peptides, saccharides, peptides for antigen presentation, metals, drugs, and proteins. The ABC transporters not only move a variety of substrates into and out of the cell, but are also involved in intracellular compartmental transport. Energy derived from the hydrolysis of ATP is used to transport the substrate across the membrane against a concentration gradient. Human genome contains 48 ABC genes; 16 of these have a known function and 14 are associated with a defined human disease (Dean et al. 2001, Borst and Elferink 2002, Rees et al. 2009).

UnificationXref8434
type: UnificationXref
id: REACT_25925
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25925.2

Evidence1058
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15522866
xref: http://identifiers.org/pubmed/11940519
comment: NHE6 (SLC9A6) (Brett CL et al, 2002; Nakamura N et al, 2005) is expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in early endosomes.

http://identifiers.org/pubmed/9083101
type: PublicationXref
id: 9083101
author: Hosaka, K
author: Nikawa, J
author: Nakashima, A
db: Pubmed
title: Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant
source: J Biol Chem 272:9567-72
year: 1997

UnificationXref8439
type: UnificationXref
id: Q12675
db: UniProt

Evidence1052
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8507690
xref: http://identifiers.org/pubmed/10777694
xref: http://identifiers.org/pubmed/15209530
xref: http://identifiers.org/pubmed/8411712
xref: http://identifiers.org/pubmed/12176987
xref: http://identifiers.org/pubmed/11248239
comment: The 70-kDa peroxisomal membrane protein (PMP70) and the adrenoleukodystrophy protein (ALDP) are half ATP binding cassette (ABC) transporters in the peroxisome membrane. Mutations in the ALD gene encoding ALDP result in the X-linked neurodegenerative disorder adrenoleukodystrophy (Roerig et al. 2001). They are involved in metabolic transport of long and very long chain fatty acids into peroxisomes. ATP binding/hydrolysis by and phosphorylation of PMP70 and ALDP are involved in the regulation of fatty acid transport into peroxisomes (Tanaka et al. 2002).

Evidence1051
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: RNA metabolism consists of both mRNA degradative pathways and non-coding RNA metabolism. Non-coding RNA metabolism includes the processing and packaging of the small nuclear ribonucleoproteins (snRNPs).

UnificationXref8441
type: UnificationXref
id: P32660
db: UniProt

Evidence1054
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9883897
xref: http://identifiers.org/pubmed/15215243
xref: http://identifiers.org/pubmed/10196363
xref: http://identifiers.org/pubmed/9878413
xref: http://identifiers.org/pubmed/10922475
xref: http://identifiers.org/pubmed/15225610
xref: http://identifiers.org/pubmed/12892562
comment: Mitochondrial ABC transporters are thought to play a key role in iron metabolism and heme biosynthesis. All mitochondrial ABC transporters described to date are of the half-transporter type and would probably function as dimers (Ramjeesingh et al. 2003) but their dimerization partners have not yet been identified. ABC7 is the functional human orthologue of yeast Atm1p (Csere et al. 1998), is predicted to dimerize in the same way as Atm1p (Chloupková et al. 2004) and is probably involved in iron homeostasis. Defects in ABCB7 are the cause of X-linked sideroblastic anemia with ataxia (ASAT) [MIM:301310] (Allikmets et al. 1999). Human genes ABCB8 and ABCB10 encode mABC1 and mABC2 respectively (Hogue et al. 1999, Zhang et al 2000 respectively). They would be expected to dimerize, as demonstrated for mABC2 (Graf et al. 2004). Both are believed to have similar functionality to ABC7 although this has not been demonstrated yet.

UnificationXref8440
type: UnificationXref
id: 3671736
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671736

Evidence1053
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11229879
xref: http://identifiers.org/pubmed/11048892
comment: A defined subset of the ABC transporter superfamily, the ABCA transporters, are highly expressed in monocytes and macrophages and are regulated by cholesterol flux which may indicate their role in in chronic inflammatory diseases (Schmitz and Kaminski 2001, Schmitz et al. 2000).

Evidence1050
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Once synthesized mRNA can be utilized until degraded. Degradation itself is the final mode of gene expression regulation.

UnificationXref8448
type: UnificationXref
id: 3671747
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671747

UnificationXref8449
type: UnificationXref
id: REACT_145546
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145546.5

UnificationXref8446
type: UnificationXref
id: 3671744
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671744

UnificationXref8447
type: UnificationXref
id: 3671745
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671745

UnificationXref8444
type: UnificationXref
id: 3671742
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671742

Evidence1068
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15276077
comment: The human gene SLC30A1 encodes the zinc transporter ZnT1. It is widely expressed throughout the body and it's expression is regulated by zinc. ZnT1 is the only member of the SLC30 gene family that is located on the plasma membrane and mediates the transport of zinc out of the cell (Devergnas S et al, 2004).

UnificationXref8445
type: UnificationXref
id: 3671743
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671743

Evidence1069
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11904301
comment: The human gene SLC30A5 encodes the zinc transporter ZnT5. This protein is widely expressed but is most abundant in pancreatic beta cells (Kambe T et al, 2002). In these cells, ZnT5 mediates the transport of zinc into secretory granules that contain insulin.

UnificationXref8442
type: UnificationXref
id: 3671740
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671740

Evidence1066
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18660845
xref: http://identifiers.org/pubmed/12568659
comment: Class II facilitative transporters consist of GLUT5, 7, 9 and 11 (Zhao FQ and Keating AF, 2007; Wood IS and Trayhurn P, 2003).

UnificationXref8443
type: UnificationXref
id: 3671741
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671741

Evidence1067
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18660845
xref: http://identifiers.org/pubmed/12568659
xref: http://identifiers.org/pubmed/11780753
comment: Two gene families are responsible for glucose transport in humans. SLC2 (encoding GLUTs) and SLC5 (encoding SGLTs) families mediate glucose absorption in the small intestine, glucose reabsorption in the kidney, glucose uptake by the brain across the blood-brain barrier and glucose release by all cells in the body. Glucose is the main energy source used by cells to make energy. Im mammals, blood glucose levels are tightly controlled and glucose is taken up from interstitial fluid by a passive, facilitative transport driven by the diffusion gradient of glucose (and other sugars) across the plasma membrane. This process is mediated by a family of Na+-independent, facilitative glucose transporters (GLUTs) encoded by the SLC2A gene family (Zhao FQ and Keating AF, 2007; Wood IS and Trayhurn P, 2003). There are 14 members belonging to this family (GLUT1-12, 14 and HMIT (H+/myo-inositol symporter)). The GLUT family can be subdivided into three subclasses (I-III) based on sequence similarity and characteristic sequence motifs (Joost HG and Thorens B, 2001).

UnificationXref8452
type: UnificationXref
id: 3673553
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673553

Evidence1065
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14739288
xref: http://identifiers.org/pubmed/18327257
xref: http://identifiers.org/pubmed/10860667
comment: The human SLC2A9 gene encodes two isoforms of class II facilitative glucose transporter 9; GLUT9 (Phay JE et al, 2000) and GLUT9DeltaN (Augustin R et al, 2004). GLUT9 is expressed mainly in kidney (proximal tubules of epithelial cells) and liver while GLUT9DeltaN is expressed mainly in kidney and placenta. As well as mediating the uptake of fructose and glucose (at a low rate), GLUT9 can also mediate the tranpsort of urate (uric acid), the end product of purine metabolism in humans and great apes (Vitart V et al, 2008). Mutations in SLC2A9 influence serum urate concentrations with excess serum accumulation of urate leading to the development of gout (Vitart V et al, 2008).

UnificationXref8451
type: UnificationXref
id: REACT_142551
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142551.5

Evidence1064
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15033637
xref: http://identifiers.org/pubmed/11583593
xref: http://identifiers.org/pubmed/16154905
xref: http://identifiers.org/pubmed/11741323
comment: SLC2A7 encodes GLUT7, a class II facilitative glucose transporter which was cloned from a human intestinal cDNA library (Li Q et al, 2004). It has a high affinity for glucose and fructose uptake. GLUT7 is found predominantly in the small intestine, colon, testis and prostate. SLC2A11 encodes GLUT11 (Doege H et al, 2001), another member of the class II facilitative glucose transporters. It has the highest similarity with GLUT5 and in humans, three isoforms are expressed (GLUT11A-C) (Sasaki T et al, 2001). Human GLUT11 has been shown to transport glucose and fructose but not galactose when expressed in Xenopus oocytes ( Scheepers A et al, 2005).

UnificationXref8450
type: UnificationXref
id: 3671763
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671763

Evidence1063
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3399500
xref: http://identifiers.org/pubmed/10987651
xref: http://identifiers.org/pubmed/10227690
xref: http://identifiers.org/pubmed/1756912
xref: http://identifiers.org/pubmed/2656669
xref: http://identifiers.org/pubmed/3170580
xref: http://identifiers.org/pubmed/1918382
xref: http://identifiers.org/pubmed/3839598
comment: The class I facilitative glucose transporters contain GLUT1-4. As well as glucose, these proteins can transport other hexoses such as fructose, galactose and glucosamine. GLUT1 was cloned from a HepG2 cell line (Mueckler M et al, 1985). GLUT1 is expressed by SLC2A1 mainly in brain and erythrocytes but is also expressed at lower levels in many other tissues containing endothelial and epithelial barriers. Defects in SLC2A1 are the cause of autosomal dominant GLUT1 deficiency syndrome which results in impaired glucose transport across the brain tissue barrier and is characterized by infantile seizures, delayed development and acquired microcephaly (Klepper J et al, 1999). GLUT2 is expressed by SLC2A2 and is a low affinity glucose transporter (Fukumoto H et al, 1988). It is expressed mainly in the kidney, liver and pancreatic beta-cells. In beta-cells, it functions as a glucose-sensor for insulin secretion and in the liver, it allows for bi-directional glucose transport. In this reaction, it is shown to mediate the influx of glucose. In the next reaction, it is shown to be mediating efflux of glucose. Defects in SLC2A2 are the cause of Fanconi-Bickel syndrome (FBS). It is characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose (Burwinkel B et al, 1999). SLC2A3 encodes GLUT3 which is mainly expressed in the brain but also in a wide range of tissues. If has a high affinity for glucose and can also transport other sugars (Kayano T et al, 1988). GLUT4, encoded by SLC2A4, is an insulin-responsive glucose transporter found in heart, skeletal muscle, brain and adipose tissue. Due to its sensitivity to insulin, it may play a role in diabetes. In a non-insulin condition, GLUT4 is localized in intracellular GLUT4-containing vesicles. On insulin stimulation, GLUT4 translocates to the plasma membrane where it can increase glucose transport 10-20-fold (Fukumoto H et al, 1989). Defects in SLC2A4 may be …

Evidence1062
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12759754
xref: http://identifiers.org/pubmed/12734757
xref: http://identifiers.org/pubmed/18400693
xref: http://identifiers.org/pubmed/18690016
xref: http://identifiers.org/pubmed/17581921
xref: http://identifiers.org/pubmed/16955105
xref: http://identifiers.org/pubmed/17693766
xref: http://identifiers.org/pubmed/12845533
xref: http://identifiers.org/pubmed/18195086
xref: http://identifiers.org/pubmed/12739168
xref: http://identifiers.org/pubmed/16461757
xref: http://identifiers.org/pubmed/19164095
comment: Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+- and/or Clâ-dependent transport of basic anions [e.g. HCO3â, (CO3)2â] in various tissues and cell types (in addition to pH regulation, specific members of this family also contribute to vectorial trans-epithelial base transport in several organ systems including the kidney, pancreas, and eye) (Pushkin A and Kurtz I, 2006); SLC8 is a group of Na+/Ca2+ exchangers (SLC8A1 is involved in cardiac contractility) (Quednau BD et al, 2004); SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers (Altimimi HF and Schnetkamp PP, 2007); SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons (Orlowski J and Grinstein S, 2004); SLC12 functions as Na+, K+ and Clâ ion electroneutral symporters (Hebert SC et al, 2004); SLC26 is the trans-epithelial multifunctional anion (e.g. sulfate, oxalate, HCO3â, Clâ) exchanger family, important in cartilage development, production of thyroid hormone, sound amplification in the cochlea etc (Sindic A et al, 2007; Dorwart MR et al, 2008; Ashmore J, 2008). SLC34 is an important Type II Na+/(HPO4)2â symporter (Forster IC et al, 2006; Virkki LV et al, 2007); SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/(H2PO4)â symporter (Collins JF et al, 2004; Virkki LV et al, 2007). Eight SLC gene families are involved in the transport of amino acids and oligopeptides.

Evidence1061
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11279194
xref: http://identifiers.org/pubmed/15522866
xref: http://identifiers.org/pubmed/12845533
comment: The SLC9 gene family encode proteins (sodium/proton exchangers, NHE or NHX) which exchange sodium (influx) for protons (efflux) electroneutrally. This mechanism is important because many metabolic processes generate acids which need to be removed to maintain pH. This is the major proton extruding system in cells, driven by the inward sodium ion chemical gradient. To date, there are eleven NHE genes, NHE1-11. NHE1-5 exchange cations at the cell membrane. NHE6-9 exchange cations at endosomal membranes or the trans-golgi network membranes.

Evidence1060
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15522866
comment: NHE9 (SLC9A9) (Nakamura N et al, 2005) is expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in the late endosome membrane.

Evidence1033
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11604561
xref: http://identifiers.org/pubmed/12411949
xref: http://identifiers.org/pubmed/10798271
xref: PublicationXref1922
xref: PublicationXref1923
comment: Hemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in character. Under acute vascular trauma, vasoconstrictor mechanisms predominate and the endothelium becomes prothrombotic, procoagulatory and proinflammatory in nature. This is achieved by a reduction of endothelial dilating agents: adenosine, NO and prostacyclin; and by the direct action of ADP, serotonin and thromboxane on vascular smooth muscle cells to elicit their contraction (Becker et al. 2000). The chief trigger for the change in endothelial function that leads to the formation of a haemostatic thrombus is the loss of the endothelial cell barrier between blood and extracellular matrix components (Ruggeri 2002). Circulating platelets identify and discriminate areas of endothelial lesions; here, they adhere to the exposed sub endothelium. Their interaction with the various thrombogenic substrates and locally generated or released agonists results in platelet activation. This process is described as possessing two stages, firstly, adhesion - the initial tethering to a surface, and secondly aggregation - the platelet-platelet cohesion (Savage & Cattaneo et al. 2001). Three mechansism contribute to the loss of blood following vessel injury. The vessel constricts, reducing the loss of blood. Platelets adhere to the site of injury, become activated and aggregate with fibrinogen into a soft plug that limits blood loss, a process termed primary hemostasis. Proteins and small molecules are released from granules by activated platelets, stimulating the plug formation process. Fibrinogen from plasma forms bridges between activated platelets. These events initiate the clotting cascade (secondary hemostasis). Negatively-charged phospholipids exposed at the site of injury and on act…

UnificationXref8410
type: UnificationXref
id: 3673548
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673548

Evidence1034
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16186825
xref: http://identifiers.org/pubmed/13130464
xref: http://identifiers.org/pubmed/17875933
xref: http://identifiers.org/pubmed/11062067
xref: http://identifiers.org/pubmed/9162092
xref: http://identifiers.org/pubmed/18713996
comment: Activated human JNK kinases (MKK4 and MKK7) phosphorylate Thr183 and Tyr185 residues in the characteristic Thr-Pro-Tyr phosphoacceptor loop of each JNK. JNK is differentially regulated by MKK4 and MKK7 depending on the stimulus. MKK7 is the primary activator of JNK in TNF, LPS, and PGN responses. However, TLR3 cascade requires both MKK4 and MKK7. Some studies reported that in three JNK isoforms tested MKK4 shows a striking preference for the tyrosine residue (Tyr-185), and MKK7 a striking preference for the threonine residue (Thr-183).

UnificationXref8411
type: UnificationXref
id: REACT_135135
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135135.5

Evidence1035
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9195981
xref: http://identifiers.org/pubmed/12193592
xref: http://identifiers.org/pubmed/13130464
comment: c-Jun NH2 terminal kinase (JNK) plays a role in conveying signals from the cytosol to the nucleus, where they associate and activate their target transcription factors.

UnificationXref8412
type: UnificationXref
id: 3673549
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673549

Evidence1036
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8177321
xref: http://identifiers.org/pubmed/15837794
xref: http://identifiers.org/pubmed/11460167
xref: http://identifiers.org/pubmed/13130464
xref: http://identifiers.org/pubmed/9851932
xref: http://identifiers.org/pubmed/16937364
comment: C-Jun NH2 terminal kinases (JNKs) are an evolutionarily conserved family of serine/threonine protein kinases, that belong to mitogen activated protein kinase family (MAPKs - also known as stress-activated protein kinases, SAPKs). The JNK pathway is activated by heat shock, or inflammatory cytokines, or UV radiation. The JNKs are encoded by at least three genes: JNK1/SAPK-gamma, JNK2/SAPK-alpha and JNK3/ SAPK-beta. The first two are ubiquitously expressed, whereas the JNK3 protein is found mainly in brain and to a lesser extent in heart and testes. As a result of alternative gene splicing all cells express distinct active forms of JNK from 46 to 55 kDa in size. Sequence alignment of these different products shows homologies of >80%. In spite of this similarity, the multiple JNK isoforms differ in their ability to bind and phosphorylate different target proteins, thus leading to the distinctive cellular processes: induction of apoptosis, or enhancment of cell survival, or proliferation. Activation of JNKs is mediated by activated TAK1 which phosphorylates two dual specificity enzymes MKK4 (MAPK kinase 4) and MKK7(MAPK kinase 7).

UnificationXref8413
type: UnificationXref
id: REACT_145989
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145989.5

Evidence1037
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9768359
xref: http://identifiers.org/pubmed/7535770
comment: The p38 activators MKK3 and MKK6 were present in both the nucleus and the cytoplasm, consistent with a role in activating p38 in the nucleus.

UnificationXref8414
type: UnificationXref
id: 167012
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167012

Evidence1038
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15837794
xref: http://identifiers.org/pubmed/8622669
xref: http://identifiers.org/pubmed/10878576
xref: http://identifiers.org/pubmed/8533096
comment: p38 mitogen-activated protein kinase (MAPK) belongs to a highly conserved family of serine/threonine protein kinases. The p38 MAPK-dependent signaling cascade is activated by pro-inflammatory or stressful stimuli such as ultraviolet radiation, oxidative injury, heat shock, cytokines, and other pro-inflammatory stimuli. p38 MAPK exists as four isoforms (alpha, beta, gamma, and delta). Of these, p38alpha and p38beta are ubiquitously expressed while p38gamma and p38delta are differentially expressed depending on tissue type. Each isoform is activated by upstream kinases including MAP kinase kinases (MKK) 3, 4, and 6, which in turn are phosphorylated by activated TAK1 at the typical Ser-Xaa-Ala-Xaa-Thr motif in their activation loops. Once p38 MAPK is phosphorylated it activates numerous downstream substrates, including MAPK-activated protein kinase-2 and 3 (MAPKAPK-2 or 3) and mitogen and stress-activated kinase-1/2 (MSK1/2). MAPKAPK-2/3 and MSK1/2 function to phosphorylate heat shock protein 27 (HSP27) and cAMP-response element binding protein transcriptional factor, respectively. Other transcription factors, including activating transcription factor 2, Elk, CHOP/GADD153, and myocyte enhancer factor 2, are known to be regulated by these kinases.

UnificationXref8415
type: UnificationXref
id: REACT_10868
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10868.2

Evidence1039
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11242034
xref: http://identifiers.org/pubmed/19196711
xref: http://identifiers.org/pubmed/17637696
xref: http://identifiers.org/pubmed/11861597
comment: The mitogen activated protein kinase (MAPK) cascade, one of the most ancient and evolutionarily conserved signaling pathways, is involved in many processes of immune responses. The MAP kinases cascade transduces signals from the cell membrane to the nucleus in response to a wide range of stimuli (Chang and Karin, 2001; Johnson et al, 2002). There are three major groups of MAP kinases the extracellular signal-regulated protein kinases ERK1/2, the p38 MAP kinase and the c-Jun NH-terminal kinases JNK. ERK1 and ERK2 are activated in response to growth stimuli. Both JNKs and p38-MAPK are activated in response to a variety of cellular and environmental stresses. The MAP kinases are activated by dual phosphorylation of Thr and Tyr within the tripeptide motif Thr-Xaa-Tyr. The sequence of this tripeptide motif is different in each group of MAP kinases: ERK (Thr-Glu-Tyr); p38 (Thr-Gly-Tyr); and JNK (Thr-Pro-Tyr). MAPK activation is mediated by signal transduction in the conserved three-tiered kinase cascade: MAPKKKK (MAP4K or MKKKK or MAPKKK Kinase) activates the MAPKKK. The MAPKKKs then phosphorylates a dual-specificity protein kinase MAPKK, which in turn phosphorylates the MAPK. The dual specificity MAP kinase kinases (MAPKK or MKK) differ for each group of MAPK. The ERK MAP kinases are activated by the MKK1 and MKK2; the p38 MAP kinases are activated by MKK3, MKK4, and MKK6; and the JNK pathway is activated by MKK4 and MKK7. The ability of MAP kinase kinases (MKKs, or MEKs) to recognize their cognate MAPKs is facilitated by a short docking motif (the D-site) in the MKK N-terminus, which binds to a complementary region on the MAPK. MAPKs then recognize many of their targets using the same strategy, because many MAPK substrates also contain D-sites. The upstream signaling events in the TLR cascade that initiate and mediate the ERK signaling pathway remain unclear.

UnificationXref8416
type: UnificationXref
id: P13586
db: UniProt

UnificationXref8417
type: UnificationXref
id: 3671723
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671723

UnificationXref8418
type: UnificationXref
id: 3671724
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671724

UnificationXref8419
type: UnificationXref
id: 3671725
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671725

http://identifiers.org/pubmed/10958654
type: PublicationXref
id: 10958654
author: Vincent, MF
author: Marie, S
author: Van den Berghe, G
author: Race, V
db: Pubmed
title: Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency
source: Hum Mol Genet 9:2159-2165
year: 2000

Evidence1030
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15659646
xref: http://identifiers.org/pubmed/2146510
comment: Kinesin-14 proteins have a C-terminal motor domain. At least four members of the group (Dm Ncd, Sc KAR3, Cg CHO2, At KCBP) have been demonstrated to be minus-end directed motors (Walker et al. 1990), in contrast to the usual plus-end directed motility of other kinesin proteins. During spindle formation, Kinesin-14 cross-links antiparallel microtubules and slides them together (thereby generating inward forces) to balance the outward forces generated by plus-end-directed kinesins of the Kinesin-5 family. Kinesin-14 family members also gather microtubule minus-ends and focus them into spindle poles. Mutation or inhibition of Kinesin-14 family members often results in disordered or splayed meiotic spindle poles (Ambrose et al. 2005).

Evidence1032
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16322778
xref: http://identifiers.org/pubmed/10613901
xref: http://identifiers.org/pubmed/16118320
xref: http://identifiers.org/pubmed/16856888
xref: http://identifiers.org/pubmed/12871295
xref: http://identifiers.org/pubmed/14702636
xref: http://identifiers.org/pubmed/17934486
xref: http://identifiers.org/pubmed/15665109
xref: http://identifiers.org/pubmed/17635743
xref: http://identifiers.org/pubmed/15354260
comment: Megakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they undergo endoreduplication (polyploidisation) and expansion of cytoplasmic mass to cell sizes larger than 50-100 microns, and ploidy ranges up to 128 N. As MK's mature, the polyploid nucleus becomes horseshoe-shaped, the cytoplasm expands, and platelet organelles and the demarcation membrane system are amplified. Proplatelet projections form which give rise to de novo circulating platelets (Deutsch & Tomer 2006). The processes of megakaryocytopoiesis and platelet production occur within a complex microenvironment where chemokines, cytokines and adhesive interactions play major roles (Avecilla et al. 2004). Megakaryocytopoiesis is regulated at several levels including proliferation, differentiation and platelet release (Kaushansky 2003). Thrombopoietin (TPO/c-Mpl ligand) is the most potent cytokine stimulating proliferation and maturation of MK progenitors (Kaushansky 2005) but many other growth factors are involved. MK development is controlled by the action of multiple Transcriptin Factors, many MK-specific genes are co-regulated by GATA and friend of GATA (FOG), RUNX1 and ETS proteins. Nuclear factor erythroid 2 (NF-E2) which has an MK-erythroid specific 45-kDa subunit controls terminal MK maturation, proplatelet formation and platelet release (Schulze & Shivdasani 2004). NF-E2 deficient mice have profound thrombocytopenia (Shiraga et al. 1999). c-myb functions with p300 as a negative regulator of thrombopoiesis (Metcalf et al. 2005). During MK maturation, internal membrane systems, granules and organelles are assembled. Cytoplasmic fragmentation requires changes in the MK cytoskeleton and formation of organelles and channels. Individual organelles migrate from the cell body to the proplatelet ends, with approximately 30 percent of organelles/granules in motion at any given ti…

Evidence1031
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20930137
xref: http://identifiers.org/pubmed/19851335
xref: http://identifiers.org/pubmed/15479732
xref: PublicationXref1907
xref: http://identifiers.org/pubmed/18626067
comment: Kinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 families of kinesins, all reprsented in humans. A standardized nomenclature was published in 2004 (Lawrence et al.).

UnificationXref8422
type: UnificationXref
id: REACT_130709
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130709.5

Evidence1046
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15298336
xref: http://identifiers.org/pubmed/11575290
xref: http://identifiers.org/pubmed/18094957
xref: http://identifiers.org/pubmed/12591178
comment: The normal development of the pancreas during gestation has been intensively investigated over the past decade especially in the mouse (Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003). Studies of genetic defects associated with maturity onset diabetes of the young (MODY) has provided direct insight into these processes as they take place in humans (Fajans et al. 2001). During embryogenesis, committed epithelial cells from the early pancreatic buds differentiate into mature endocrine and exocrine cells. It is helpful to schematize this process into four consecutive cellular stages, to begin to describe the complex interplay of signal transduction pathways and transcriptional networks. The annotations here are by no means complete - factors in addition to the ones described here must be active, and even for the ones that are described, only key examples of their regulatory effects and interactions have been annotated. It is also important to realize that in the human, unlike the mouse, cells of the different stages can be present simultaneously in the developing pancreas and the linear representation of these developmental events shown here is an over-simplification of the actual developmental process (e.g., Sarkar et al. 2008). The first stage of this process involves the predifferentiated epithelial cells of the two pancreatic anlagen that arise from the definitive endoderm at approximately somite stages 11-15 and undergo budding from somite stages 20-22. This period corresponds to gestational days 8.75-9.5 in the mouse, and 26 in the human. Pancreatic buds subsequently coalesce to form a single primitive gland, while concomitantly a ductal tree lined by highly proliferative epithelial cells is formed. A subset of such epithelial cells is thought to differentiate into either endocrine or acinar exocrine cells. A third cellular stage is defined by the endocrine-committed progenitors that selectively express the basic helix-loop-helix transcription factor NEUR…

UnificationXref8423
type: UnificationXref
id: GO:0009897
db: GENE ONTOLOGY

Evidence1047
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8325954
comment: The GLUT4 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

UnificationXref8420
type: UnificationXref
id: 3671726
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671726

Evidence1044
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11978637
xref: http://identifiers.org/pubmed/11575290
comment: The GLUT2 gene is transcribed, its mRNA is translated, and the protein product is localized to the plasma membrane. GLUT2 expression is positively regulated by HNF1A. In vivo, pancreatic GLUT2 expression is positively regulated by HNF1A. Mutations in HNF1A are associated with a form of MODY (maturity onset diabetes of the young) (Fanjans et al. 2001) and interactions between the HNF1A protein product and the GLUT2 promoter have been demomstrated in vitro (Ban et al. 2002). However, the molecular details of GLUT2 expression in intact pancreatic beta cells have not been studied in humans, but are inferred from corresponding ones worked out in the mouse.

UnificationXref8421
type: UnificationXref
id: 3671728
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671728

Evidence1045
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15298336
xref: http://identifiers.org/pubmed/12591178
comment: Two transcription factors, PDX1 and HNF1A, play key roles in maintaining the gene expression pattern characteristic of mature beta cells in the endocrine pancreas. Targets of these regulatory molecules include genes encoding insulin, the GLUT2 glucose transporter, the liver- (and pancreas) specific form of pyruvate kinase and other transcription factors including HNF4A, HNF4G, and FOXA3. PDX1 expression in turn is controlled by the activities of MAFA, FOXA2, and PAX6, and negatively regulated via AKT (Chakrabarti and Mirmira 2003; Servitja and Ferrer 2004).

UnificationXref8426
type: UnificationXref
id: 939747
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939747

UniProt:Q02887
type: ProteinReference
xref: UnificationXref9880
organism: BioSource1

UnificationXref8427
type: UnificationXref
id: REACT_26138
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26138.2

http://identifiers.org/pubmed/17765544
type: PublicationXref
id: 17765544
author: Cote, Jean-Francois
author: Vuori, K
db: Pubmed
title: GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
source: Trends Cell Biol 17:383-93
year: 2007

UnificationXref8424
type: UnificationXref
id: 947595
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=947595

Evidence1048
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18518822
xref: http://identifiers.org/pubmed/8970730
xref: http://identifiers.org/pubmed/7838715
xref: http://identifiers.org/pubmed/17060461
xref: http://identifiers.org/pubmed/1840554
xref: http://identifiers.org/pubmed/15860371
xref: http://identifiers.org/pubmed/7531665
xref: http://identifiers.org/pubmed/17956727
xref: http://identifiers.org/pubmed/10603305
xref: http://identifiers.org/pubmed/17139329
xref: http://identifiers.org/pubmed/17475546
xref: http://identifiers.org/pubmed/16380219
xref: http://identifiers.org/pubmed/21082419
xref: http://identifiers.org/pubmed/17011499
xref: http://identifiers.org/pubmed/20054179
xref: http://identifiers.org/pubmed/16054042
comment: Adipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develop morphologic and biochemical characteristics of mature adipocytes such as hormone responsive lipogenenic and lipolytic programs. The most intensively studied model system for adipogenesis is differentiation of the mouse 3T3-L1 preadipocyte cell line by an induction cocktail of containing mitogens (insulin/IGF1), glucocorticoid (dexamethasone), an inducer of cAMP (IBMX), and fetal serum (Cao et al. 1991, reviewed in Farmer 2006). More recently additional cellular models have become available to study adipogenesis that involve almost all stages of development (reviewed in Rosen and MacDougald 2006). In vivo knockout mice lacking putative adipogenic factors have also been extensively studied. Human pathways are traditionally inferred from those discovered in mouse but are now beginning to be validated in cellular models derived from human adipose progenitors (Fischer-Posovszky et al. 2008, Wdziekonski et al. 2011). Adipogenesis is controlled by a cascade of transcription factors (Yeh et al. 1995, reviewed in Farmer 2006, Gesta et al. 2007). One of the first observable events during adipocyte differentiation is a transient increase in expression of the CEBPB (CCAAT/Enhancer Binding Protein Beta, C/EBPB) and CEBPD (C/EBPD) transcription factors (Cao et al. 1991, reviewed in Lane et al. 1999). This occurs prior to the accumulation of lipid droplets. However, it is the subsequent inductions of CEBPA and PPARG that are critical for morphological, biochemical and functional adipocytes. Ectopic expression of CEBPB alone is capable of inducing substantial adipocyte differentiation in fibroblasts while CEBPD has a minimal effect. CEBPB is upregulated in response to intracellular cAMP (possibly via pCREB) and serum mitogens (possibly via Krox20). CEBPD is upregulated in response to …

UnificationXref8425
type: UnificationXref
id: REACT_25558
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25558.2

Evidence1049
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: As a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are aspects of the roles of cell adhesion molecules in axonal guidance and myogenesis, of transcriptional regulation in hematopoiesis (specifically, B lymphopoiesis), pancreatic beta cell and white adipocyte differentiation, and molecular events of "nodal" signaling.

UniProt:Q02883
type: ProteinReference
xref: UnificationXref2227
organism: BioSource1

UnificationXref8428
type: UnificationXref
id: 947594
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=947594

UniProt:Q12377
type: ProteinReference
xref: UnificationXref1062
organism: BioSource1

UnificationXref8429
type: UnificationXref
id: REACT_26259
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26259.2

p53-Independent DNA Damage Response
type: Pathway
data source: Provenance1
pathway component: REACT 108674.9
evidence: Evidence73
xref: UnificationXref963
xref: UnificationXref962
pathway order: PathwayStep76
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

YM9958.08C
type: ProteinReference
name: YML054C
name: CYB2
name: UniProt:P00175 CYB2
xref: UnificationXref570
comment: CATALYTIC ACTIVITY (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+).COFACTOR FMN.COFACTOR Protoheme IX groups.SUBUNIT Homotetramer.INDUCTION By L-lactate. Induced during respiratory adaptation.MISCELLANEOUS Present with 4590 molecules/cell in log phase SD medium.SIMILARITY Contains 1 cytochrome b5 heme-binding domain.SIMILARITY Contains 1 FMN hydroxy acid dehydrogenase domain.
organism: BioSource1

http://identifiers.org/pubmed/12151002
type: PublicationXref
id: 12151002
author: Paiement, J
author: Desjardins, M
author: Bergeron, JJ
author: Cameron, PH
author: Duclos, S
author: Chevet, E
author: Gagnon, E
author: Steele-Mortimer, O
author: Rondeau, C
db: Pubmed
title: Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages
source: Cell 110:119-31
year: 2002

UnificationXref8430
type: UnificationXref
id: GO:0009898
db: GENE ONTOLOGY

Evidence1043
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: The glucokinase (GCK) gene is transcribed and its mRNA is translated. GCK transcription is positively regulated by the activity of the NEUROD1 and PDX1 transcription factors. These events and interactions are inferred from corresponding ones studied in molecular detail in the mouse.

Evidence1042
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Axon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, which senses the guidance cues in the environment through guidance cue receptors and responds by undergoing cytoskeletal changes that determine the direction of axon growth. Guidance cues present in the surrounding environment provide the necessary directional information for the trip. These extrinsic cues have been divided into attractive or repulsive signals that tell the growth cone where and where not to grow. Genetic and biochemical studies have led to the identification of highly conserved families of guidance molecules and their receptors that guide axons. These include netrins, Slits, semaphorins, and ephrins, and their cognate receptors, DCC and or uncoordinated-5 (UNC5), roundabouts (Robo), neuropilin and Eph. In addition, many other classes of adhesion molecules are also used by growth cones to navigate properly which include NCAM and L1CAM.

Evidence1041
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12700044
xref: http://identifiers.org/pubmed/12587671
xref: http://identifiers.org/pubmed/17975827
xref: http://identifiers.org/pubmed/15662836
xref: http://identifiers.org/pubmed/15153429
xref: http://identifiers.org/pubmed/18760361
comment: The neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the nervous system. The role of NCAM in neural differentiation and synaptic plasticity is presumed to depend on the modulation of intracellular signal transduction cascades. NCAM based signaling complexes can initiate downstream intracellular signals by at least two mechanisms: (1) activation of FGFR and (2) formation of intracellular signaling complexes by direct interaction with cytoplasmic interaction partners such as Fyn and FAK. Tyrosine kinases Fyn and FAK interact with NCAM and undergo phosphorylation and this transiently activates the MAPK, ERK 1 and 2, cAMP response element binding protein (CREB) and transcription factors ELK and NFkB. CREB activates transcription of genes which are important for axonal growth, survival, and synaptic plasticity in neurons. NCAM1 mediated intracellular signal transduction is represented in the figure below. The Ig domains in NCAM1 are represented in orange ovals and Fn domains in green squares. The tyrosine residues susceptible to phosphorylation are represented in red circles and their positions are numbered. Phosphorylation is represented by red arrows and dephosphorylation by yellow. Ig, Immunoglobulin domain; Fn, Fibronectin domain; Fyn, Proto-oncogene tyrosine-protein kinase Fyn; FAK, focal adhesion kinase; RPTPalpha, Receptor-type tyrosine-protein phosphatase; Grb2, Growth factor receptor-bound protein 2; SOS, Son of sevenless homolog; Raf, RAF proto-oncogene serine/threonine-protein kinase; MEK, MAPK and ERK kinase; ERK, Extracellular signal-regulated kinase; MSK1, Mitogen and stress activated protein kinase 1; CREB, Cyclic AMP-responsive element-binding protein; CRE, cAMP response elements.

Evidence1040
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12609980
xref: http://identifiers.org/pubmed/19112497
xref: http://identifiers.org/pubmed/19675569
comment: In human, together with ubiquitin-conjugating E2-type enzymes UBC13 and UEV1A (also known as UBE2V1), TRAF6 catalyses Lys63-linked ubiquitination. It is believed that auto polyubiquitination and oligomerization of TRAF6 is followed by binding the ubiquitin receptors of TAB2 or TAB3 (TAK1 binding protein 2 and 3), which stimulates phosphorylation and activation of TGF beta-activated kinase 1(TAK1). TAK1 phosphorylates IKK alpha and IKK beta, which in turn phosphorylate NF-kB inhibitors - IkB and eventually results in IkB degradation and NF-kB translocation to the nucleus. Also TAK1 mediates JNK and p38 MAP kinases activation by phosphorylating MKK4/7 and MKK3/6 respectivly resulting in the activation of many transcription factors. The role of TRAF6 is somewhat controversial and probably cell type specific. TRAF6 autoubiquitination was found to be dispensable for TRAF6 function to activate TAK1 pathway. These findings are consistent with the new mechanism of TRAF6-mediated NF-kB activation that was suggested by Xia et al. (2009). TRAF6 generates unanchored Lys63-linked polyubiquitin chains that bind to the regulatory subunits of TAK1 (TAB2 or TAB3) and IKK(NEMO), leading to the activation of the kinases. Xia et al. (2009) demonstrated in vitro that unlike polyubiquitin chains covalently attached to TRAF6 or IRAK, TAB2 and NEMO-associated ubiquitin chains were found to be unanchored and susceptible to N-terminal ubiquitin cleavage. Only K63-linked polyubiquitin chains, but not monomeric ubiquitin, activated TAK1 in a dose-dependent manner. Optimal activation of the IKK complex was achieved using ubiquitin polymers containing both K48 and K63 linkages. Furthermore, the authors proposed that the TAK1 complexes might be brougt in close proximity by binding several TAB2/3 to a single polyubiquitin chain to facilitate TAK1 kinase trans-phosphorylation. Alternativly, the possibility that polyUb binding promotes allosteric activation of TAK1 complex should be considered (Wals…

http://identifiers.org/pubmed/1717476
type: PublicationXref
id: 1717476
author: Hunter, T
author: Pines, J
db: Pubmed
title: Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport
source: J Cell Biol 115:1-17
year: 1991

http://identifiers.org/pubmed/11347887
type: PublicationXref
id: 11347887
author: Hou, YM
author: King, MP
author: Davidson, E
author: Vitseva, O
author: Caffarella, J
db: Pubmed
title: Isolation of two cDNAs encoding functional human cytoplasmic cysteinyl-tRNA synthetase
source: Biol Chem 382:399-406
year: 2001

UnificationXref8407
type: UnificationXref
id: 3667971
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667971

UnificationXref8406
type: UnificationXref
id: 3667926
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667926

UnificationXref8409
type: UnificationXref
id: REACT_125930
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125930.5

UnificationXref8408
type: UnificationXref
id: 3671653
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671653

UnificationXref8403
type: UnificationXref
id: 3667909
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667909

UnificationXref8402
type: UnificationXref
id: 3667908
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667908

UnificationXref8405
type: UnificationXref
id: 3667925
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667925

UnificationXref8404
type: UnificationXref
id: 3667913
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667913

UnificationXref8401
type: UnificationXref
id: 3667907
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667907

UnificationXref8400
type: UnificationXref
id: 3667906
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667906

http://identifiers.org/pubmed/10413847
type: PublicationXref
id: 10413847
author: Bläker, M
author: de Weerth, A
author: von Schrenck, T
db: Pubmed
title: [Receptors for cholecystokinin and gastrin]
source: Z Gastroenterol 37:389-401
year: 1999

http://identifiers.org/pubmed/19196647
type: PublicationXref
id: 19196647
author: McCrea, HJ
author: De Camilli, P
db: Pubmed
title: Mutations in phosphoinositide metabolizing enzymes and human disease
source: Physiology (Bethesda) 24:8-16
year: 2009

UniProt:Q12330
type: ProteinReference
xref: UnificationXref2443
organism: BioSource1

D0884
type: ProteinReference
name: YDL217C
name: UniProt:Q12328 TIM22
name: TIM22
xref: UnificationXref561
comment: FUNCTION Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins, such as mitochondrial carrier family members, into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps. Mediates the insertion of precursor proteins in a 3 step process. After the precursor is tethered to the translocase without losing energy from the Delta(psi), 2 energy-requiring steps are needed. First, Delta(psi) acts on the precursor protein and promotes its docking in the translocase complex. Then, Delta(psi) and an internal signal peptide together induce rapid gating transitions in one pore and closing of the other pore and drive membrane insertion to completion.SUBUNIT Component of the TIM22 complex, whose core is composed of TIM18, TIM22 and TIM54, associated with the peripheral proteins MRS5/TIM12 and the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13).SIMILARITY Belongs to the Tim17/Tim22/Tim23 family.
organism: BioSource1

1,2-diacyl-sn-glycerol
type: SmallMoleculeReference
name: ChEBI:17815 1,2-diacyl-sn-glycerol
xref: UnificationXref3384

http://identifiers.org/pubmed/17637696
type: PublicationXref
id: 17637696
author: Gerondakis, S
author: Banerjee, A
db: Pubmed
title: Coordinating TLR-activated signaling pathways in cells of the immune system
source: Immunol Cell Biol 85:420-4
year: 2007

UniProt:Q12311
type: ProteinReference
xref: UnificationXref7927
organism: BioSource1

http://identifiers.org/pubmed/21029861
type: PublicationXref
id: 21029861
author: Hogg, JR
author: Goff, SP
db: Pubmed
title: Upf1 senses 3'UTR length to potentiate mRNA decay
source: Cell 143:379-89
year: 2010

http://identifiers.org/pubmed/11278511
type: PublicationXref
id: 11278511
author: Ding, WC
author: Berger, SH
author: Lebioda, L
author: Koli, S
author: Minor, W
author: Dunlap, RB
author: Phan, J
author: Steadman, DJ
db: Pubmed
title: Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
source: J Biol Chem 276:14170-7
year: 2001

UniProt:Q12306
type: ProteinReference
xref: UnificationXref3
organism: BioSource1

http://identifiers.org/pubmed/16143825
type: PublicationXref
id: 16143825
author: Briere, JJ
author: El Ghouzzi, V
author: Djouadi, F
author: Favier, J
author: Gimenez, AP
author: Benit, P
author: Rustin, P
db: Pubmed
title: Succinate dehydrogenase deficiency in human
source: Cell Mol Life Sci 62:2317â2324
year: 2005

http://identifiers.org/pubmed/9477959
type: PublicationXref
id: 9477959
author: Gould, GW
author: De la Rue, SA
author: Porter, LM
author: Seatter, MJ
db: Pubmed
title: QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 position of D-glucose and is involved in substrate selection at the exofacial binding site.
source: Biochemistry 37:1322-6
year: 1998

http://identifiers.org/pubmed/10536157
type: PublicationXref
id: 10536157
author: Wu, X
author: Zhang, Y
author: Xin, H
author: Lin, W
author: Yuan, F
db: Pubmed
title: The human REV1 gene codes for a DNA template-dependent dCMP transferase.
source: Nucleic Acids Res 27:4468-75
year: 1999

http://identifiers.org/pubmed/11278508
type: PublicationXref
id: 11278508
author: Chairoungdua, A
author: Kanai, Y
author: Kim, DK
author: Matsuo, H
author: Cha, SH
author: Endou, H
db: Pubmed
title: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters
source: J Biol Chem 276:17221-8
year: 2001

http://identifiers.org/pubmed/18538142
type: PublicationXref
id: 18538142
author: Hunt, MC
author: Alexson, SE
db: Pubmed
title: Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism
source: Prog Lipid Res 47:405-21
year: 2008

http://identifiers.org/pubmed/16483568
type: PublicationXref
id: 16483568
author: Da Silva, CA
author: Frossard, N
author: Reber, L
db: Pubmed
title: Stem cell factor and its receptor c-Kit as targets for inflammatory diseases
source: Eur J Pharmacol 533:327-40
year: 2006

Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
type: Pathway
data source: Provenance1
pathway component: Formation of tubulin folding intermediates by CCT/TriC
pathway component: Folding of actin by CCT/TriC
evidence: Evidence1359
xref: UnificationXref9376
xref: UnificationXref9375
pathway order: PathwayStep1360
pathway order: PathwayStep1358
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/13115431
type: PublicationXref
id: 13115431
author: Lieberman, I
author: Kornberg, A
db: Pubmed
title: Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase
source: Biochim Biophys Acta 12:223-234
year: 1953

http://identifiers.org/pubmed/11598006
type: PublicationXref
id: 11598006
author: Neupert, W
author: Diekert, K
author: Niggemeyer, B
author: Lill, R
author: Ahting, U
author: de Kruijff, B
author: de Kroon, AI
db: Pubmed
title: Apocytochrome c requires the TOM complex for translocation across the mitochondrial outer membrane
source: EMBO J 20:5626-35
year: 2001

http://identifiers.org/pubmed/8163488
type: PublicationXref
id: 8163488
author: Schlossmann, J
author: Neupert, W
author: Pfanner, N
author: Dietmeier, K
db: Pubmed
title: Specific recognition of mitochondrial preproteins by the cytosolic domain of the import receptor MOM72
source: J Biol Chem 269:11893-901
year: 1994

http://identifiers.org/pubmed/20188572
type: PublicationXref
id: 20188572
author: von Lintig, Johannes
author: Palczewski, Krzysztof
author: Kiser, Philip D
author: Golczak, Marcin
db: Pubmed
title: The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision
source: Trends Biochem. Sci. 35:400-10
year: 2010

http://identifiers.org/pubmed/22952392
type: PublicationXref
id: 22952392
author: Nusse, Roel
author: Willert, Karl
db: Pubmed
title: Wnt proteins
source: Cold Spring Harb Perspect Biol 4:a007864
year: 2012

http://identifiers.org/pubmed/5324173
type: PublicationXref
id: 5324173
author: Berg, P
author: Baldwin, AN
db: Pubmed
title: Transfer ribonucleic acid-induced hydrolysis of valyladenylate bound to isoleucyl ribonucleic acid synthetase
source: J Biol Chem 241:839-45
year: 1966

http://identifiers.org/pubmed/5324172
type: PublicationXref
id: 5324172
author: Berg, P
author: Baldwin, AN
db: Pubmed
title: Purification and properties of isoleucyl ribonucleic acid synthetase from Escherichia coli
source: J Biol Chem 241:831-8
year: 1966

http://identifiers.org/pubmed/18802415
type: PublicationXref
id: 18802415
author: Ko, CH
author: Takahashi, JS
author: Hong, HK
author: McDearmon, EL
db: Pubmed
title: The genetics of mammalian circadian order and disorder: implications for physiology and disease
source: Nat Rev Genet 9:764-75
year: 2008

http://identifiers.org/pubmed/15526160
type: PublicationXref
id: 15526160
author: Rönnstrand, L
db: Pubmed
title: Signal transduction via the stem cell factor receptor/c-Kit
source: Cell Mol Life Sci 61:2535-48
year: 2004

Acyl chain remodeling of DAG and TAG
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction295
evidence: Evidence479
xref: UnificationXref4050
xref: RelationshipXref378
xref: UnificationXref4051
pathway order: PathwayStep476
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/2462567
type: PublicationXref
id: 2462567
author: de Jong, WW
author: Stapel, SO
author: Lietman, T
author: Wistow, GJ
author: Piatigorsky, J
author: Williams, LA
author: Horwitz, J
db: Pubmed
title: Tau-crystallin/alpha-enolase: one gene encodes both an enzyme and a lens structural protein
source: J Cell Biol 107:2729-36
year: 1988

UniProt:P24482
type: ProteinReference
xref: UnificationXref297
organism: BioSource1

http://identifiers.org/pubmed/10496324
type: PublicationXref
id: 10496324
author: Dharmawardhane, S
author: Lennartz, M
author: Bokoch, GM
author: Brownson, D
db: Pubmed
title: Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils
source: J Leukoc Biol 66:521-7
year: 1999

ModificationFeature106
type: ModificationFeature
feature location: SequenceSite1221
comment: Insertion of residues 429 to 822 at 340 from UniProt:P11362 FGFR1 (in Homo sapiens)

http://identifiers.org/pubmed/12324224
type: PublicationXref
id: 12324224
author: Sprecher, H
db: Pubmed
title: The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids
source: Prostaglandins Leukot Essent Fatty Acids 67:79-83
year: 2002

Mitotic Prophase
type: Pathway
data source: Provenance1
pathway component: REACT 154278.3
evidence: Evidence22
xref: UnificationXref126
xref: UnificationXref125
xref: RelationshipXref16
pathway order: PathwayStep17
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/19010334
type: PublicationXref
id: 19010334
author: Neupert, W
author: Grumbt, B
author: Reddehase, S
author: Hell, K
db: Pubmed
title: The disulfide relay system of mitochondria is required for the biogenesis of mitochondrial Ccs1 and Sod1
source: J Mol Biol 385:331-8
year: 2009

http://identifiers.org/pubmed/11533233
type: PublicationXref
id: 11533233
author: Fox, PL
author: Sonenberg, N
author: Imataka, H
author: Seshadri, V
author: Mazumder, B
db: Pubmed
title: Translational silencing of ceruloplasmin requires the essential elements of mRNA circularization: poly(A) tail, poly(A)-binding protein, and eukaryotic translation initiation factor 4G
source: Mol Cell Biol 21:6440-9
year: 2001

http://identifiers.org/pubmed/9741684
type: PublicationXref
id: 9741684
author: Edwards, PA
author: Shell, BK
author: Greene, JM
author: Ericsson, J
author: Carter, KC
author: Florence, C
author: Duan, DR
db: Pubmed
title: Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression
source: J Lipid Res 39:1731-9
year: 1998

http://identifiers.org/pubmed/9188776
type: PublicationXref
id: 9188776
author: Rider, MH
author: Veiga-da-Cunha, M
author: Gerin, I
author: Van Schaftingen, E
author: Collet, JF
db: Pubmed
title: Human L-3-phosphoserine phosphatase: sequence, expression and evidence for a phosphoenzyme intermediate
source: FEBS Lett 408:281-4
year: 1997

Phosphoenolpyruvic acid
type: SmallMoleculeReference
name: Phosphoenolpyruvate
name: Phosphoenolpyruvate [ChEBI:18021]
name: PEP
xref: UnificationXref2676

http://identifiers.org/pubmed/10101268
type: PublicationXref
id: 10101268
author: Heilmeyer LM, Jr
author: Gehrmann, T
author: Balla, A
author: Herberg, FW
author: Mayr, Georg W
author: Suer, S
author: Gülkan, H
author: Vereb, G
db: Pubmed
title: Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230
source: Biochim Biophys Acta 1437:341-56
year: 1999

UniProt:P16140
type: ProteinReference
xref: UnificationXref1977
organism: BioSource1

Evidence1125
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of '3-phosphoinositide dependent protein kinase-1 ', and 1 molecule of 'Phosphatidylinositol-3,4,5-trisphosphate' are present. At the end of this reaction, 1 molecule of 'PIP3:PDK complex [plasma membrane]' is present. This reaction takes place in the 'cell'.

Evidence1128
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: SOS is recruited to the plasma membrane and mediates activation of Ras.

Evidence1124
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: PKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.

http://identifiers.org/pubmed/10615129
type: PublicationXref
id: 10615129
author: Mauro, T
author: Ikeda, S
author: Bonifas, JM
author: Beech, J
author: Bench, G
author: Ogawa, H
author: Hu, Z
author: Shigihara, T
author: Epstein EH, Jr
db: Pubmed
title: Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease
source: Nat Genet 24:61-5
year: 2000

Evidence1129
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Release of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.

diacylglycerols
type: SmallMoleculeReference
name: diacylglycerols [ChEBI:18035]
xref: UnificationXref2000

Evidence1117
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15755954
comment: mTOR forms a functional protein complex with at least two proteins: Raptor (Regulated Associated Protein of mTOR) and mLst8. This complex is called mammalian TOR complex 1 (mTORC1). Raptor serves as a scaffolding protein to bridge the interaction between mTOR and its substrates. mLst8 enhances the association of mTOR with Raptor. [Rheb:GTP] binds and activates mTORC1. Besides binding directly to mTOR, Rheb can also bind to Raptor and mLst8 (PMIDs 15854902, 15755954 and 12150926).

Evidence1116
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15951850
comment: Rheb is a GTP binding protein that exhibits GTPase activity. GDP is exchanged for GTP in the [Rheb:GDP] complex to form [Rheb:GTP], which binds and activates the mTORC1 complex. This exchange is catalysed by an as yet unidentified guanine exchange factor (GEF) (PMIDs 15951850 and 15755954).

Evidence1114
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: SHC is one of the mediators of insulin signalling events. It is activated by phosphorylation and triggers a cascade of events involving SOS, RAF and the MAP kinases.

Evidence1113
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Release of phospho-SHC from the insulin receptor triggers a cascade of signalling events via SOS, RAF and the MAP kinases.

Evidence1111
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2160
xref: http://identifiers.org/pubmed/15071553
comment: Ion channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore for the flow of ions. There are different types of ion channels. P-type ATPases undergo conformational changes to translocate ions. Ligand-gated ion channels operate like a gate, opened or closed by a chemical signal. Voltage-gated ion channels are activated by changes in electrical potential difference at the membrane (Purves, 2001; Kuhlbrandt, 2004).

Evidence1110
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15071553
comment: The P-type ATPases (E1-E2 ATPases) are a large group of evolutionarily related ion pumps that are found in bacteria, archaea and eukaryotes. They are referred to as P-type ATPases because they catalyze auto-phosphorylation of a key conserved aspartate residue within the pump. They all appear to interconvert between at least two different conformations, E1 and E2. Most members of this transporter family pump a large variety of cations (Kuhlbrandt W, 2004).

Evidence1119
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15809305
comment: Once phosphorylated, S6K1-P phosphorylates and activates ribosomal protein S6 (rpS6), which in turn selectively increases the translation of 5ââ¬â¢TOP mRNAs. These mRNAs encode exclusively for components of the translation machinery (PMID 15809305).

Evidence1118
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15809305
comment: S6K1 contains a TOS motif. mTORC1 requires an intact TOS motif to bind and phosphorylate S6K1 (PMID 15809305).

http://identifiers.org/pubmed/15548136
type: PublicationXref
id: 15548136
author: Zhao, ZS
author: Manser, E
db: Pubmed
title: PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation
source: Biochem J 386:201-14
year: 2005

Evidence1140
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12692556
comment: RhoA is activated by guanine nucleotide exchange factors (RhoGEF), exchanging GDP for GTP. RHOA, activated following binding of MDGIs to the NgR:p75NTR complex, rigidifies the actin cytoskeleton, thereby inhibiting axonal elongation and causing growth cone collapse.

Evidence1141
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12951563
comment: p75NTR can also form a receptor complex with the Nogo receptor (NgR). Such complexes mediates axonal outgrowth inhibitory signals of MDGIs (myelin-derived growth-inhibitors), such as Nogo66, myelin-associated glycoprotein (MAG), and oligodendrocyte myelin glycoprotein (OMGP).

Evidence1142
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17335080
comment: p75NTR modulates axonal growth by regulating the activity of small GTPases like RHOA and RHOB, that control the state of actin polymerization. The best studied is RHOA. In its active, GTP-bound form, RHOA rigidifies the actin cytoskeleton, thereby inhibiting axonal elongation and causing growth cone collapse. Depending on the ligand that binds to it, p75NTR can either promote or inhibit axonal growth, Neurotrophin binding leads to inhibition of RHOA activity and axonal growth. Axonal growth inhibition is caused by myelin molecules named MDGIs (myelin-derived growth inhibitors), such as NOGO, MAG, OMGP. MDGIs bind to a complex made up of p75NTR and the NOGO receptor, causing RHOA activation and axonal growth inhibition.

Evidence1144
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11520933
comment: Signalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation of MAPK found in NGF-treated cells.

Evidence1143
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16939974
xref: http://identifiers.org/pubmed/16699811
xref: http://identifiers.org/pubmed/12671646
xref: http://identifiers.org/pubmed/16025106
comment: Besides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a number of downstream signalling events controlling survival, death, proliferation, and axonogenesis, according to the cellular context. p75NTR is devoid of enzymatic activity, and signals by recruiting other proteins to its own intracellular domain. p75 interacting proteins include NRIF, TRAF2, 4, and 6, NRAGE, necdin, SC1, NADE, RhoA, Rac, ARMS, RIP2, FAP and PLAIDD. Here we annotate only the proteins for which a clear involvement in p75NTR signalling was demonstrated. A peculiarity of p75NTR is the ability to bind the pro-neurotrophins proNGF and proBDNF. Proneurotrophins do not associate with TRK receptors, whereas they efficiently signal cell death by apoptosis through p75NTR. The biological action of neurotrophins is thus regulated by proteolytic cleavage, with proforms preferentially activating p75NTR, mediating apoptosis, and mature forms activating TRK receptors, to promote survival. Moreover, the two receptors are utilised to differentially modulate neuronal plasticity. For instance, proBDNF-p75NTR signalling facilitates LTD, long term depression, in the hippocampus (Woo NH, et al, 2005), while BDNF-TRKB signalling promotes LTP (long term potentiation). Many biological observations indicate a functional interaction between p75NTR and TRKA signaling pathways.

Evidence1146
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9069267
comment: The adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.

Evidence1145
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10712923
comment: RIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT and RIN lack a typical prenylation motif (CAAX, XXCC, or CXC) required for the association of RAS proteins with the plasma membrane. RIT is expressed in all tissues, whereas RIN is neuron-specific. They have similar signalling properties and are activated by NGF through unknown exchange factors. They signal to ERKs and p38 MAP kinase. They mainly lead to p38 activation via the BRAF-MEK kinase cascade.

Evidence1148
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9069267
xref: http://identifiers.org/pubmed/12765839
comment: After NGF binding, activated Trk receptors provide multiple docking sites for adaptor proteins and enzymes. Two docking proteins, the Ankyrin-Rich Membrane Spanning protein (ARMS/Kidins220) and Fibroblast growth factor receptor substrate 2 (Frs2), target signaling molecules in response to NGF stimulation and link receptor activation with the MAP kinase (also called the Extracellular signal-Regulated Kinase cascade, ERK) cascade, an essential process for growth factor-induced cell proliferation and differentiation. A feature of NGF signaling is the sustained activation of the MAPK cascade. This is achieved by the small G protein, Rap1 which binds to and activates B-Raf, an activator of the MAPK cascade. Rap1 is a member of the Ras family of G proteins and like all G proteins, Rap1 is in an inactive state when bound to GDP and is active when bound to GTP. A specific GEF (guanine nucleotide exchange factor) called C3G can activate Rap1 by exchanging GDP for GTP.

Evidence1147
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9069267
comment: ARMS (Ankyrin-Rich Membrane Spanning/Kidins 220) is a 220kD tetraspanning adaptor protein which becomes rapidly tyrosine phosphorylated by active Trk receptors. ARMS is another adaptor protein which is involved in the activation of Rap1 and the subsequent prolonged activation of the MAPK cascade.

Evidence1149
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10508738
comment: Neurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS, ocurring from caveolae in the plasma membrane or from clathrin-coated vesicles, and via RAP1, taking place in early endosomes. Whereas RAS activation by NGF is transient, RAP1 activation by NGF is sustained for hours.

L-Glutamine
type: SmallMoleculeReference
name: L-Glutamine [ChEBI:18050]
name: L-2-Aminoglutaramic acid
xref: UnificationXref515

http://identifiers.org/pubmed/18692476
type: PublicationXref
id: 18692476
author: Riggs, B
author: Loughlin, R
author: Heald, R
db: Pubmed
title: SnapShot: motor proteins in spindle assembly
source: Cell 134:548-548.e1
year: 2008

Evidence1130
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: IRS is one of the mediators of insulin signalling events. It is activated by phosphorylation and triggers a cascade of events involving PI3K, SOS, RAF and the MAP kinases. The proteins mentioned under IRS are examples of IRS family members acting as indicated. More family members are to be confirmed and added in the future.

Evidence1131
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11282018
xref: http://identifiers.org/pubmed/9677303
comment: Autophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the autophosphorylation of the insulin receptor is its internalisation into an endosome, which downregulates its signalling activity.

http://identifiers.org/pubmed/7678419
type: PublicationXref
id: 7678419
author: Smith, BL
author: Agre, P
author: Knepper, MA
author: Christensen, EI
author: Nielsen, S
db: Pubmed
title: CHIP28 water channels are localized in constitutively water-permeable segments of the nephron
source: J Cell Biol 120:371-83
year: 1993

Evidence1135
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12097334
comment: The different molecules listed (NRAGE, NRIF, NADE, TRAF6) mediate, through unclear mechanisms, JNK activation by threonine and tyrosine phosphorylation. While active JNK does move to the nucleus and phosphorylates and activate transcription factors such as c-JUN and ATF2, these have not been implicated in p75-mediated cell death, but rather the direct activation of the cell death machinery by JNK has been implicated. p75 activates the intrinsic caspase pathway (involving mitochondrial release of cytochrome c, Apaf-1, and caspases-9) rather than the extrinsic (caspase-8) pathway activated by most other death receptors.

Evidence1134
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Insulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor tyrosine kinase. This allows association of IRSs with downstream effectors such as PI-3K via its Src homology 2 (SH2) domains leading to end point events such as Glut4 translocation. Shc when tyrosine phosphorylated associates with Grb2 and can thus activate the Ras/MAPK pathway independent of the IRSs. Signal transduction by the insulin receptor is not limited to its activation at the cell surface. The activated ligand-receptor complex initially at the cell surface, is internalised into endosomes itself a process which is dependent on tyrosine autophosphorylation. Endocytosis of activated receptors has the dual effect of concentrating receptors within endosomes and allows the insulin receptor tyrosine kinase to phosphorylate substrates that are spatially distinct from those accessible at the plasma membrane. Acidification of the endosomal lumen, due to the presence of proton pumps, results in dissociation of insulin from its receptor. (The endosome constitutes the major site of insulin degradation). This loss of the ligand-receptor complex attenuates any further insulin-driven receptor re-phosphorylation events and leads to receptor dephosphorylation by extra-lumenal endosomally-associated protein tyrosine phosphatases (PTPs). The identity of these PTPs is not clearly established yet. A discussion of candidates will be added in the near future.

Evidence1133
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Triggered by acidification of the endosome, insulin dissociates from the receptor and is degraded. The receptor is dephosphorylated and re-integrated into the plasma membrane, ready to be activated again by the binding of insulin molecules.

Evidence1132
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8682206
xref: http://identifiers.org/pubmed/3061785
xref: http://identifiers.org/pubmed/9793760
comment: The effect of the proton pump is to allow entry of [H+] ions into the lumen of the endosome. The net effect of this is to lower the pH of the lumen from pH 7.4 (the pH at the plasma membrane) to pH 6.0 (documented with studies using FITC-labeled insulin - a pH dependent fluorescence marker).

Evidence1139
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12676795
comment: In certain cell types, ligand binding to p75NTR leads to ceramide production, which can mediate either cell survival (e.g. in noecotical subplate neurons) or apoptosis (e.g. in oligodendrocytes). Low levels of ceramide are also able to stimulate axonal outgrowth in hippocampal neurons.

Evidence1138
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Sphingomyielinase promotes the conversion of sphingomyelin to ceramide. Ceramide can activate JNK and other targets. The molecular details of the p75NTR-activated ceramide signalling cascade are only partially understood.

Evidence1137
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12787561
comment: p75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNGF is at least 10 times more potent than mature NGF in inducing apoptosis. TRKA signalling protects neurons from apoptosis. The molecular mechanisms involved in p75NTR-apoptosis are not well understood. The death signalling requires activation of c-JUN N-terminal Kinase (JNK), as well as transcriptional events. JNK activation appears to involve the receptor interacting proteins TRAF6, NRAGE, and Rac. The transcription events are thought to be regulated by another p75-interacting protein, NRIF. Two other p75-interacting proteins, NADE and Necdin, have been implicated in apoptosis, but their role is less clear.

Evidence1136
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12376548
comment: Once bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pro-apoptotic genes, and directly activates the cell death machinery. Only NGF-bound p75NTR is shown here.

L13a-mediated translational silencing of Ceruloplasmin expression
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction80
pathway component: BiochemicalReaction81
evidence: Evidence158
xref: UnificationXref1766
xref: UnificationXref1765
pathway order: PathwayStep160
pathway order: PathwayStep161
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8395
type: UnificationXref
id: 3667901
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667901

UnificationXref8394
type: UnificationXref
id: 3667900
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667900

http://identifiers.org/pubmed/9412462
type: PublicationXref
id: 9412462
author: Srinivasan, M
author: Leung, RS
author: Holder, J
author: Kerscher, O
author: Jensen, RE
db: Pubmed
title: The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane
source: J Cell Biol 139:1663-75
year: 1997

UnificationXref8397
type: UnificationXref
id: 3667903
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667903

UnificationXref8396
type: UnificationXref
id: 3667902
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667902

UnificationXref8391
type: UnificationXref
id: 3667894
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667894

UnificationXref8390
type: UnificationXref
id: 3667924
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667924

UnificationXref8393
type: UnificationXref
id: 3667899
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667899

UnificationXref8392
type: UnificationXref
id: 3667898
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667898

UDPglucose
type: SmallMoleculeReference
name: UDP-D-glucose
name: UDPglucose [ChEBI:18066]
name: UDP-glucose
xref: UnificationXref2807

UnificationXref8387
type: UnificationXref
id: 3667918
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667918

UnificationXref8388
type: UnificationXref
id: 3667922
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667922

UnificationXref8389
type: UnificationXref
id: 3667923
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667923

http://identifiers.org/pubmed/16477023
type: PublicationXref
id: 16477023
author: Oda, SI
author: Hino, T
author: Yoshida, T
author: Sugimoto, H
author: Otsuki, T
author: Shiro, Y
db: Pubmed
title: Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase
source: Proc Natl Acad Sci USA 103:2611-2616
year: 2006

UnificationXref8386
type: UnificationXref
id: 3667917
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667917

UnificationXref8385
type: UnificationXref
id: REACT_5598
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5598.2

UnificationXref8384
type: UnificationXref
id: 74722
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74722

UnificationXref8383
type: UnificationXref
id: GO:0031904
db: GENE ONTOLOGY

UnificationXref8382
type: UnificationXref
id: REACT_108009
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108009.9

UnificationXref8381
type: UnificationXref
id: 3673324
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673324

UnificationXref8380
type: UnificationXref
id: REACT_133215
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133215.5

dTDP
type: SmallMoleculeReference
name: Deoxythymidine 5'-diphosphate
name: dTDP [ChEBI:18075]
xref: UnificationXref5399

TTP
type: SmallMoleculeReference
name: Deoxythymidine 5'-triphosphate
name: dTTP
name: Deoxythymidine triphosphate
name: dTTP [ChEBI:18077]
xref: UnificationXref1036

ABCA transporters in lipid homeostasis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction686
pathway component: BiochemicalReaction211
evidence: Evidence1053
xref: UnificationXref8089
xref: UnificationXref8088
pathway order: PathwayStep1060
pathway order: PathwayStep360
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

3-Hexaprenyl-4,5-dihydroxybenzoate
type: SmallMoleculeReference
name: 3-Hexaprenyl-4,5-dihydroxybenzoate [ChEBI:1509]
xref: UnificationXref4690

UnificationXref8378
type: UnificationXref
id: REACT_159896
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159896.3

UnificationXref8379
type: UnificationXref
id: 3673507
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673507

UnificationXref8376
type: UnificationXref
id: REACT_155301
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155301.3

UnificationXref8377
type: UnificationXref
id: 3670869
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670869

http://identifiers.org/pubmed/11459976
type: PublicationXref
id: 11459976
author: Bell, SP
author: Klemm, RD
db: Pubmed
title: ATP bound to the origin recognition complex is important for preRC formation.
source: Proc Natl Acad Sci U S A 98:8361-7
year: 2001

Evidence1107
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15831496
xref: http://identifiers.org/pubmed/10767338
xref: http://identifiers.org/pubmed/10615129
comment: Accumulation of calcium into the Golgi apparatus is mediated by sarco(endo)plasmic reticulum calcium-ATPases (SERCAs) and by secretory pathway calcium-ATPases (SPCAs). There are two human genes which encode SPCAs; ATP2C1 and ATP2C2 which encode magnesium-dependent calcium-transporting ATPase type 2C members 1 and 2 (ATP2C1 and 2) respectively (Sudbrak et al, 2000; Vanoevelen et al, 2005). Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD), an autosomal dominant disease characterized by persistent blisters and erosions of the skin (Hu et al, 2000).

Evidence1108
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15919184
comment: The plasma membrane contains a broad range of lipids making up the bilayer. Aminophospholipids such as phosphatidylserine (PS) and phosphatidylethanolamine (PE) are distributed in this bilayer and their arrangement is mediated by the P-type ATPases type IV family (Paulusma and Oude Elferink, 2005).

http://identifiers.org/pubmed/16790493
type: PublicationXref
id: 16790493
author: Stuart, RA
author: Dienhart, MK
author: Long, RM
author: Gallas, MR
db: Pubmed
title: Characterization of Mmp37p, a Saccharomyces cerevisiae mitochondrial matrix protein with a role in mitochondrial protein import
source: Mol Biol Cell 17:4051-62
year: 2006

Evidence1109
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15919184
comment: The plasma membrane contains a broad range of lipids making up the bilayer. Aminophospholipids (APLs) such as phosphatidylserine (PS) and phosphatidylethanolamine (PE) are distributed in this bilayer and their arrangement is mediated by the P-type ATPases type IV family (Paulusma and Oude Elferink, 2005).

Evidence1100
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16325777
xref: http://identifiers.org/pubmed/18555844
xref: http://identifiers.org/pubmed/17961083
xref: http://identifiers.org/pubmed/9405233
xref: http://identifiers.org/pubmed/11952783
comment: Aquaporin-7 (AQP7) passively transports glycerol and water across the plasma membrane according to the osmotic gradient. AQP7 is expressed in adipocytes under the direct control of the PPARG and RXRA nuclear receptors. Expression of AQP7 correlates with release of glycerol from adipocytes. AQP7 is seen to translocate from the nuclear periphery to the plasma membrane during adrenaline-stimulated lipolysis. In rat AQP7 also transports urea.

Evidence1101
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10564231
xref: http://identifiers.org/pubmed/18762715
xref: http://identifiers.org/pubmed/17961083
xref: http://identifiers.org/pubmed/19590626
xref: http://identifiers.org/pubmed/11027599
comment: Aquaporin-9 (AQP9) passively transports water, glycerol, urea, and some other small neutral solutes across the plasma membrane according to the osmotic gradient. AQP9 is expressed in the sinusoidal plasma membrane in the liver facing the portal vein where it is believed to be responsible for glycerol uptake as part of gluconeogenesis. AQP9 is also expressed in glia, neurons, and peripheral leukocytes.

Evidence1102
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19096781
xref: http://identifiers.org/pubmed/16764946
comment: Triglycerides stored in adipocytes are hydrolyzed to yield fatty acids and glycerol. The glycerol is passively transported out of the adipocyte and into the bloodstream by Aquaporin-7 (AQP7) located in the plasma membrane of adipocytes. Glycerol in the bloodstream is passively transported into liver cells by AQP9 located in the plasma membrane of hepatocytes. Once inside the liver cell the glycerol is a substrate for gluconeogenesis.

DNA Replication Pre-Initiation
type: Pathway
data source: Provenance1
pathway component: REACT 81836.9
pathway component: REACT 92729.9
evidence: Evidence43
xref: UnificationXref310
xref: UnificationXref311
pathway order: PathwayStep38
pathway order: PathwayStep33
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence1103
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19448080
xref: http://identifiers.org/pubmed/15809071
xref: http://identifiers.org/pubmed/15340377
xref: http://identifiers.org/pubmed/17961083
xref: http://identifiers.org/pubmed/16107722
xref: http://identifiers.org/pubmed/15901243
xref: http://identifiers.org/pubmed/16650285
xref: http://identifiers.org/pubmed/20224213
xref: http://identifiers.org/pubmed/19096770
xref: http://identifiers.org/pubmed/11773613
xref: http://identifiers.org/pubmed/17222168
xref: http://identifiers.org/pubmed/15924268
comment: Aquaporins (AQP's) are six-pass transmembrane proteins that form channels in membranes. Each monomer contains a central channel formed in part by two asparagine-proline-alanine motifs (NPA boxes) that confer selectivity for water and/or solutes. The monomers assemble into tetramers. Most aquaporins (i.e. AQP0/MIP, AQP1, AQP2, AQP3, AQP4, AQP5, AQP7, AQP8, AQP9, AQP10) passively transport water into and out of cells according to the osmotic gradient across the membrane. Four aquaporins (the aquaglyceroporins AQP3, AQP7, AQP9, AQP10) conduct glycerol, three aquaporins (AQP7, AQP9, AQP10) conduct urea, and one aquaporin (AQP6) conducts anions, especially nitrate. AQP8 also conducts ammonia in addition to water. AQP11 and AQP12, classified as group III aquaporins, were identified as a result of the genome sequencing project and are characterized by having variations in the first NPA box when compared to more traditional aquaporins. Additionally, a conserved cysteine residue is present about 9 amino acids downstream from the second NPA box and this cysteine is considered indicative of group III aquaporins. Purified AQP11 incorporated into liposomes showed water transport. Knockout mice lacking AQP11 had fatal cyst formation in the proximal tubule of the kidney. Exogenously expressed AQP12 showed intracellular localization. AQP12 is expressed exclusively in pancreatic acinar cells. Aquaporins are important in fluid and solute transport in various tissues. In adipocytes, glycerol generated by triglyceride hydrolysis is exported by AQP7 and is imported by liver cells via AQP9. AQP1 plays a role in forming cerebrospinal fluid and AQP1, AQP4, and AQP9 appear to be important in maintaining fluid balance in the brain. AQP0, AQP1, AQP3, AQP4, AQP8, AQP9, and AQP11 play roles in the physiology of the hepatobiliary tract. In the kidney, water and solutes are passed out of the bloodstream and into the proximal tubule via the slit-like structure formed by nephrin in the glomerulus. …

Evidence1104
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17662945
comment: The function of V-type proton pumping ATPases is basically the same as that of F-type ATPases, except that V-ATPases cannot synthesize ATP from the proton motive force, the reverse reaction of pumping. When pumping, ATP hydrolysis drives a 120 degree rotation of the rotor which leads to movement of three protons into the phagosome (Adachi et al. 2007).

Evidence1105
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2874839
comment: Endocytosis of iron loaded transferrin/receptor complex leads, after acidification of the endosome, to the separation of iron and its diffusion out of the vesicle. The endosome is not fused with a lysosome but recycles its content back to the cell surface where soon transferrin dissociates from its receptor (Dautry-Varsat, 1986).

Evidence1106
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19381358
xref: http://identifiers.org/pubmed/18259769
xref: http://identifiers.org/pubmed/20495089
comment: The transport of iron between cells is mediated by transferrin. However, iron can also enter and leave cells not only by itself, but also in the form of heme and siderophores. When entering the cell via the main path (by transferrin endocytosis), its goal is not the (still elusive) chelated iron pool in the cytosol nor the lysosomes but the mitochondria, where heme is synthesized and iron-sulfur clusters are assembled (Kurz et al,2008, Hower et al 2009, Richardson et al 2010).

http://identifiers.org/pubmed/19194512
type: PublicationXref
id: 19194512
author: Chanet, Roland
author: Vernis, Laurence
author: Baldacci, Giuseppe
author: Guiard, Bernard
author: Facca, Céline
author: Faye, Gérard
author: Soler, Nicolas
author: Delagoutte, Emmanuelle
db: Pubmed
title: A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast
source: PLoS ONE 4:e4376
year: 2009

UnificationXref8398
type: UnificationXref
id: 3667904
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667904

UnificationXref8399
type: UnificationXref
id: 3667905
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667905

Evidence1199
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'Double-strand DNA containing a formamidopyrimidine ', and 1 molecule of 'hOGG1 glycosylase' are present. At the end of this reaction, 1 molecule of 'hOGG1 glycosylase: formamidopyrimidine complex' is present. This reaction takes place in the 'nucleus'.

UnificationXref8333
type: UnificationXref
id: REACT_145743
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145743.5

Evidence1198
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'Double-strand DNA containing an 8-oxo guanine opposite to a cytosine', and 1 molecule of 'hOGG1 glycosylase' are present. At the end of this reaction, 1 molecule of 'hOGG1 glycosylase:8-oxo guanine complex' is present. This reaction takes place in the 'nucleus'.

UnificationXref8332
type: UnificationXref
id: 3671449
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671449

UnificationXref8335
type: UnificationXref
id: REACT_126637
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126637.5

http://identifiers.org/pubmed/12121577
type: PublicationXref
id: 12121577
author: Safrany, ST
author: Leslie, NR
author: McLennan, AG
db: Pubmed
title: Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases
source: BMC Biochem 3:20
year: 2002

UnificationXref8334
type: UnificationXref
id: 3673536
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673536

UnificationXref8337
type: UnificationXref
id: REACT_106437
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106437.9

UnificationXref8336
type: UnificationXref
id: 3673210
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673210

Meiotic Recombination
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction572
pathway component: BiochemicalReaction573
evidence: Evidence858
xref: UnificationXref6759
xref: UnificationXref6760
pathway order: PathwayStep866
pathway order: PathwayStep865
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8339
type: UnificationXref
id: REACT_79921
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79921.9

UnificationXref8338
type: UnificationXref
id: 3673099
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673099

Evidence1190
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/22952392
xref: http://identifiers.org/pubmed/21725318
comment: Retromer is believed to escort WLS from the early endosome back to the Golgi for subsequent rounds of WNT secretion (reviewed in Johannes and Wunder, 2011; Willert and Nusse, 2012 ).

Evidence1191
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/22952392
xref: http://identifiers.org/pubmed/21554866
xref: http://identifiers.org/pubmed/17141155
xref: http://identifiers.org/pubmed/22653731
xref: http://identifiers.org/pubmed/22983114
xref: http://identifiers.org/pubmed/22796206
xref: http://identifiers.org/pubmed/17108000
xref: http://identifiers.org/pubmed/19837038
xref: http://identifiers.org/pubmed/21768372
xref: http://identifiers.org/pubmed/16678096
xref: http://identifiers.org/pubmed/16678095
xref: http://identifiers.org/pubmed/21725318
xref: http://identifiers.org/pubmed/23256519
xref: http://identifiers.org/pubmed/23260141
comment: 19 WNT proteins have been identified in human cells. The WNTs are members of a conserved metazoan family of secreted morphogens that activate several signaling pathways in the responding cell: the canonical (beta-catenin) WNT signaling cascade and several non-canonical pathways, including the planar cell polarity (PCP), the regulation of intracellular calcium signaling and activation of JNK kinases. WNT proteins exist in a gradient outside the secreting cell and are able to act over both short and long ranges to promote proliferation, changes in cell migration and polarity and tissue homeostasis, among others (reviewed in Saito-Diaz et al, 2012; Willert and Nusse, 2012). The WNTs are ~40kDa proteins with 23 conserved cysteine residues in the N-terminal that may form intramolecular disulphide bonds. They also contain an N-terminal signal sequence and a number of N-linked glycosylation sites (Janda et al, 2012). In addition to being glycosylated, WNTs are also lipid-modified in the endoplasmic reticulum by a WNT-specific O-acyl-transferase, Porcupine (PORCN), contributing to their characteristic hydrophobicity. PORCN-dependent palmitoylation is required for the secretion of WNT as well as its signaling activity, as either depletion of PORCN or mutation of the conserved serine acylation site results in the intracellular accumulation of WNT ligand (Takada et al, 2006; Barrott et al, 2011; Biechele et al, 2011; reviewed in Willert and Nusse, 2012). Secretion of WNT requires a number of other dedicated factors including the sorting receptor Wntless (WLS) (also knownas Evi, Sprinter, and GPR177), which binds WNT and escorts it to the cell surface (Bänziger et al, 2006; Bartscherer et al, 2006; Goodman et al, 2006). A WNT-specific retromer containing SNX3 is subsequently required for the recycling of WLS back to the Golgi (reviewed in Herr et al, 2012; Johannes and Wunder, 2011). Once at the cell surface, WNT makes extensive contacts with components of the extracellular mat…

Evidence1192
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/22952392
xref: http://identifiers.org/pubmed/19619488
xref: http://identifiers.org/pubmed/18710302
xref: http://identifiers.org/pubmed/16099039
xref: http://identifiers.org/pubmed/19365405
xref: http://identifiers.org/pubmed/10858654
xref: http://identifiers.org/pubmed/19204114
xref: http://identifiers.org/pubmed/17143292
xref: http://identifiers.org/pubmed/12967557
xref: http://identifiers.org/pubmed/20576942
xref: http://identifiers.org/pubmed/19530173
xref: http://identifiers.org/pubmed/17230199
xref: http://identifiers.org/pubmed/23256519
comment: WNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Saito-Diaz et al, 2013; MacDonald et al, 2009). The pathway is named for the WNT ligands, a large family of secreted cysteine-rich glycoproteins. At least 19 WNT members have been identified in humans and mice with distinct expression patterns during development (reviewed in Willert and Nusse, 2012). These ligands can activate at least three different downstream signaling cascades depending on which receptors they engage. In the so-called 'canonical' WNT signaling pathway, WNT ligands bind one of the 10 human Frizzled (FZD) receptors in conjunction with the LRP5/6 co-receptors to activate a transcriptional cascade that controls processes such as cell fate, proliferation and self-renenwal of stem cells. Engagement of the FZD-LRP receptor by WNT ligand results in the stabilization and translocation of cytosolic beta-catenin to the nucleus where it is a co-activator for LEF (lymphoid enhancer-binding factor)- and TCF (T cell factor) -dependent transcription. In the absence of WNT ligand, cytosolic beta-catenin is phosphorylated by a degradation complex consisting of glycogen synthase kinase 3 (GSK3), casein kinase 1 (CK1), Axin and Adenomatous polyposis coli (APC), and subsequently ubiquitinated and degraded by the 26S proteasome (reviewed in Saito-Diaz et al, 2013; Kimmelman and Xu, 2006). In addition to the beta-catenin-dependent transcriptional response, WNT signaling can also activate distinct non-transcriptional pathways that regulate cell migration and polarity. These beta-catenin-independent 'non-canonical' pathways signal through Frizzled receptors independently of LRP5/6, or occur through the tyrosine kinase receptors ROR and RYK (reviewed in Veeman et al, 2003; James et al, 2009). Non-canonical WNT pathways are best studied in Drosophila where the planar cell polarit…

Evidence1193
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17598937
xref: http://identifiers.org/pubmed/18927274
xref: http://identifiers.org/pubmed/20975071
xref: http://identifiers.org/pubmed/22649417
xref: http://identifiers.org/pubmed/20098959
comment: Phosphorylated IGF1R binds and phosphorylates SHC1 (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). Phosphorylated SHC then binds GRB:SOS, which activates RAS-RAF-MAPK signaling.

Evidence1194
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17598937
xref: http://identifiers.org/pubmed/18927274
xref: http://identifiers.org/pubmed/20975071
xref: http://identifiers.org/pubmed/22649417
xref: http://identifiers.org/pubmed/20098959
xref: http://identifiers.org/pubmed/21042815
comment: The phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). The phosphorylated IRS proteins serve as scaffolds that bind the effector molecules PI3K and GRB2:SOS. PI3K then activates PKB (AKT) signaling while GRB2:SOS activates RAS-RAF-MAPK signaling.

http://identifiers.org/pubmed/9556621
type: PublicationXref
id: 9556621
author: Riese DJ, 2nd
author: Stern, DF
author: Komurasaki, T
author: Plowman, GD
db: Pubmed
title: Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2
source: J Biol Chem 273:11288-94
year: 1998

Evidence1195
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17598937
xref: http://identifiers.org/pubmed/18927274
xref: http://identifiers.org/pubmed/20975071
xref: http://identifiers.org/pubmed/22649417
xref: http://identifiers.org/pubmed/20098959
xref: http://identifiers.org/pubmed/21042815
comment: After autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activity (recently reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, and Siddle et al. 2012). IRS1/2/4 can bind both PI3K (via the p85 subunit of PI3K) and the GRB2:SOS complex. PI3K activates PKB (AKT, AKT1) signaling. GRB:SOS stimulates RAS to exchange GDP for GTP leading to activation of RAF and MAPK.

UnificationXref8340
type: UnificationXref
id: 109276
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109276

Evidence1196
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17598937
xref: http://identifiers.org/pubmed/18927274
xref: http://identifiers.org/pubmed/22044904
xref: http://identifiers.org/pubmed/20975071
xref: http://identifiers.org/pubmed/22649417
xref: http://identifiers.org/pubmed/20098959
xref: http://identifiers.org/pubmed/21042815
comment: Binding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS-RAS-RAF-MAPK (ERK) pathway and the PI3K-PKB (AKT) pathway (recently reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parella et al. 2010, Annunziata et al. 2011, Siddle et al. 2012, Holzenberger 2012).

UnificationXref8341
type: UnificationXref
id: REACT_3225
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3225.1

Evidence1197
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15520807
xref: http://identifiers.org/pubmed/11742412
xref: http://identifiers.org/pubmed/19619488
xref: http://identifiers.org/pubmed/17496910
xref: http://identifiers.org/pubmed/19935667
xref: http://identifiers.org/pubmed/21252999
xref: http://identifiers.org/pubmed/19458711
xref: http://identifiers.org/pubmed/17084981
xref: http://identifiers.org/pubmed/18483217
xref: http://identifiers.org/pubmed/16260143
xref: http://identifiers.org/pubmed/19648010
xref: http://identifiers.org/pubmed/19536106
xref: http://identifiers.org/pubmed/17604717
xref: http://identifiers.org/pubmed/19762341
xref: http://identifiers.org/pubmed/19379690
xref: http://identifiers.org/pubmed/15450248
xref: http://identifiers.org/pubmed/16939974
xref: http://identifiers.org/pubmed/21781017
xref: http://identifiers.org/pubmed/18043707
xref: http://identifiers.org/pubmed/15863030
comment: Signal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such as hormones and growth factors, or reacting to other types of stimuli, such as light. Stimulation of transmembrane receptors leads to their conformational change which propagates the signal to the intracellular environment by activating downstream signaling cascades. Depending on the cellular context, this may impact cellular proliferation, differentiation, and survival. On the organism level, signal transduction regulates overall growth and behavior. Receptor tyrosine kinases (RTKs) transmit extracellular signals by phosphorylating their protein partners on conserved tyrosine residues. Some of the best studied RTKs are EGFR (reviewed in Avraham and Yarden, 2011), FGFR (reviewed in Eswarakumar et al, 2005), insulin receptor (reviewed in Saltiel and Kahn, 2001), NGF (reviewed in Reichardt, 2006), PDGF (reviewed in Andrae et al, 2008) and VEGF (reviewed in Xie et al, 2004). RTKs frequently activate downstream signaling through RAF/MAP kinases (reviewed in McKay and Morrison, 2007 and Wellbrock et al 2004), AKT (reviewed in Manning and Cantley, 2007) and PLC- gamma (reviewed in Patterson et al), which ultimately results in changes in gene expression and cellular metabolism. Receptor serine/threonine kinases of the TGF-beta family, such as TGF-beta receptors (reviewed in Kang et al. 2009) and BMP receptors (reviewed in Miyazono et al. 2009), transmit extracellular signals by phosphorylating regulatory SMAD proteins on conserved serine and threonine residues. This leads to formation of complexes of regulatory SMADs and SMAD4, which translocate to the nucleus where they act as transcription factors. WNT receptors transmit their signal through beta-catenin. In the absence of ligand, beta-catenin is constitutively degraded in a ubiquitin-dependent manner. WNT receptor stimulation…

UnificationXref8342
type: UnificationXref
id: P43549
db: UniProt

UnificationXref8346
type: UnificationXref
id: 3670871
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670871

UnificationXref8345
type: UnificationXref
id: 3670870
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670870

UnificationXref8344
type: UnificationXref
id: 3671009
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671009

http://identifiers.org/pubmed/11459989
type: PublicationXref
id: 11459989
author: Paulusma, C
author: Wyman, C
author: Kanaar, R
author: Ristic, D
db: Pubmed
title: The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA.
source: Proc Natl Acad Sci U S A 98:8454-60
year: 2001

UnificationXref8343
type: UnificationXref
id: 3671008
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671008

UnificationXref8349
type: UnificationXref
id: 3671284
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671284

UnificationXref8348
type: UnificationXref
id: 3670867
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670867

UnificationXref8347
type: UnificationXref
id: 3670866
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670866

UnificationXref8352
type: UnificationXref
id: 3671288
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671288

UnificationXref8353
type: UnificationXref
id: REACT_145708
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145708.5

UnificationXref8350
type: UnificationXref
id: 3671285
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671285

UnificationXref8351
type: UnificationXref
id: 3671286
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671286

UnificationXref8359
type: UnificationXref
id: REACT_154763
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154763.3

UnificationXref8358
type: UnificationXref
id: 3671290
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671290

UnificationXref8355
type: UnificationXref
id: REACT_137801
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137801.5

UnificationXref8354
type: UnificationXref
id: 3671291
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671291

UnificationXref8357
type: UnificationXref
id: REACT_9588
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9588.2

UnificationXref8356
type: UnificationXref
id: 192438
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192438

UnificationXref8361
type: UnificationXref
id: REACT_158154
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158154.3

UnificationXref8362
type: UnificationXref
id: 432019
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=432019

UnificationXref8363
type: UnificationXref
id: REACT_21102
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21102.1

UnificationXref8364
type: UnificationXref
id: 3671293
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671293

UnificationXref8360
type: UnificationXref
id: 3671292
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671292

UnificationXref8369
type: UnificationXref
id: 3673525
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673525

UnificationXref8368
type: UnificationXref
id: REACT_155347
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155347.3

UnificationXref8367
type: UnificationXref
id: 3671295
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671295

UnificationXref8366
type: UnificationXref
id: REACT_155332
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155332.3

UnificationXref8365
type: UnificationXref
id: 3671296
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671296

UnificationXref8374
type: UnificationXref
id: REACT_98188
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98188.9

http://identifiers.org/pubmed/10397776
type: PublicationXref
id: 10397776
author: Rassow, J
author: Kurz, M
author: Ryan, MT
author: Pfanner, N
author: Martin, H
db: Pubmed
title: Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway
source: Mol Biol Cell 10:2461-74
year: 1999

UnificationXref8375
type: UnificationXref
id: 3670873
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670873

UnificationXref8372
type: UnificationXref
id: REACT_159413
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159413.3

UnificationXref8373
type: UnificationXref
id: 3673323
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673323

UnificationXref8370
type: UnificationXref
id: REACT_100323
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100323.9

UnificationXref8371
type: UnificationXref
id: 3671011
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671011

UniProt:Q12267
type: ProteinReference
xref: UnificationXref127
organism: BioSource1

http://identifiers.org/pubmed/19196711
type: PublicationXref
id: 19196711
author: Frankson, E
author: Bardwell, L
author: Bardwell, AJ
db: Pubmed
title: Selectivity of docking sites in MAPK kinases
source: J Biol Chem 284:13165-73
year: 2009

Evidence1154
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Neurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in minute amounts, by a variety of tissues. They signal through two types of receptors: TRK tyrosine kinase receptors (TRKA, TRKB, TRKC), which specifically interact with the different neurotrophins, and p75NTR, which interacts with all neurotrophins. TRK receptors are reported in a variety of tissues in addition to neurons. p75NTRs are also widespread. Neurotrophins and their receptors are synthesized as several different splice variants, which differ in terms of their biological activities. The nerve growth factor (NGF) was the first growth factor to be identified and has served as a model for studying the mechanisms of action of neurotrophins and growth factors. The mechanisms by which NGF generates diverse cellular responses have been studied extensively in the rat pheochromocytoma cell line PC12. When exposed to NGF, PC12 cells exit the cell cycle and differentiate into sympathetic neuron-like cells. Current data show that signalling by the other neurotrophins is similar to NGF signalling.

Evidence1155
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10508235
xref: http://identifiers.org/pubmed/1374684
xref: http://identifiers.org/pubmed/9739761
comment: The role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of around 100 amino acids that can bind a phosphorylated tyrosine residue. These downstream molecules are activated upon binding to, or phosphorylated by, the receptor kinases intrinsic to PDGF receptors. Some of the dowstream molecules are themselves enzymes, such as phosphatidylinositol 3'-kinase (PI3K), phospholipase C (PLC-gamma), the Src family of tyrosine kinases, the tyrosine phosphatase SHP2, and a GTPase activating protein (GAP) for Ras. Others such as Grb2 are adaptor molecules which link the receptor with downstream catalytic molecules.

Evidence1156
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10508235
xref: http://identifiers.org/pubmed/15207811
xref: http://identifiers.org/pubmed/9739761
comment: Platelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary endothelial cells and neurons.The PDGF family of growth factors is composed of four different polypeptide chains encoded by four different genes. The classical PDGF chains, PDGF-A and PDGF-B, and more recently discovered PDGF-C and PDGF-D. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD. It is notable that no heterodimers involving PDGF-C and PDGF-D chains have been described. PDGF exerts its effects by binding to, and activating, two protein tyrosine kinase (PTK) receptors, alpha and beta. These receptors dimerize and undergo autophosphorylation. The phosphorylation sites then attract downstream effectors to transduct the signal into the cell.

Evidence1157
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16475976
xref: http://identifiers.org/pubmed/19540337
xref: http://identifiers.org/pubmed/15526160
xref: http://identifiers.org/pubmed/17350321
xref: http://identifiers.org/pubmed/7688988
xref: http://identifiers.org/pubmed/16483568
xref: http://identifiers.org/pubmed/2004790
comment: Stem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival and differentiation of hematopoetic progenitors, melanocytes and germ cells.(Linnekin 1999, Rönnstrand 2004, Lennartsson and Rönnstrand 2006). The receptor for SCF is KIT, a tyrosine kinase receptor (RTK) closely related to the receptors for platelet derived growth factor receptor, colony stimulating factor 1 (Linnekin 1999) and Flt3 (Rosnet et al. 1991). Four isoforms of c-Kit have been identified in humans. Alternative splicing results in isoforms of KIT differing in the presence or absence of four residues (GNNK) in the extracellular region. This occurs due to the use of an alternate 5' splice donor site. These GNNK+ and GNNK- variants are co-expressed in most tissues; the GNNK- form predominates and was more strongly tyrosine-phosphorylated and more rapidly internalized (Rönnstrand 2004). There are also splice variants that arise from alternative usage of splice acceptor site resulting in the presence or absence of a serine residue (Crosier et al., 1993). Finally, there is an alternative shorter transcript of KIT expressed in postmeiotic germ cells in the testis which encodes a truncated KIT consisting only of the second part of the kinase domain and thus lackig the extracellular and transmembrane domains as well as the first part of the kinase domain (Rossi et al. 1991). Binding of SCF homodimers to KIT results in KIT homodimerization followed by activation of its intrinsic tyrosine kinase activity. KIT stimulation activates a wide array of signalling pathways including MAPK, PI3K and JAK/STAT (Reber et al. 2006, Rönnstrand 2004). Defects of KIT in humans are associated with different genetic diseases and also in several types of cancers like mast cell leukaemia, germ cell tumours, certain subtypes of malignant melanoma and gastrointestinal tumours.

Evidence1158
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: All ERBB2 heterodimers, ERBB2:EGFR, ERBB2:ERBB3 and ERBB2:ERBB4, are able to activate RAF/MAP kinase cascade by recruiting SHC1 (Pinkas-Kramarski et al. 1996, Sepp-Lorenzino et al. 1996) to phosphorylated C-tail tyrosine residues in either EGFR (Y1148 and Y1173), ERBB2 (Y1196, Y1221, Y1222 and Y1248), ERBB3 (Y1328) or ERBB4 (Y1188 and Y1242 in JM-A CYT1 isoform, Y1178 and Y1232 in JM-B CYT1 isoform, Y1172 and Y1226 in JM-A CYT2 isoform). SHC1 recruitment is followed by phosphorylation (Segatto et al. 1993, Soler et al. 1994), and the phosphorylated SHC1 recruits GRB2:SOS1 complex (Xie et al. 1995), which leads to SOS1-mediated guanyl-nucleotide exchange on RAS (Xie et al. 1995) and downstream activation of RAF and MAP kinases.

Evidence1159
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: ERBB2:EGFR and ERBB2:ERBB4 can directly recruit GRB2:SOS1 complex through phosphorylated C-tail tyrosines of EGFR (Y1068 and Y1086) and ERBB2 (Y1139) that serve as docking sites for GRB2 (Xie et al. 1995, Sepp-Lorenzino et al. 1996), which, again, results in SOS1-mediated guanyl-nucleotide exchange on RAS and activation of RAF and MAP kinases (Janes et al. 1994, Sepp-Lorenzino et al. 1996).

http://identifiers.org/pubmed/8633070
type: PublicationXref
id: 8633070
author: Ullrich, A
author: Giot, JF
author: Møller, NP
author: Zahalka, MA
author: Lechner, C
db: Pubmed
title: ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation
source: Proc Natl Acad Sci U S A 93:4355-9
year: 1996

UniProt:P00044
type: ProteinReference
xref: UnificationXref6901
organism: BioSource1

Evidence1151
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Several guanine exchange factors (GEFs) for the Rho family of GTPases contain PH domains that bind to PIP3. RhoA protein activation is a mechanism whereby PI3K acts independently of AKT.

Evidence1150
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2185
xref: http://identifiers.org/pubmed/10579907
comment: The activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosphorylation by TrkA receptor kinase and this form hydrolyses PIP2 to generate inositol tris-phosphate (IP3) and diacylglycerol (DAG). IP3 promotes the release of Ca2+ from internal stores and this results in activation of enzymes such as protein kinase C and Ca2+ calmodulin-regulated protein kinases.

Evidence1153
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11520933
xref: PublicationXref2185
xref: http://identifiers.org/pubmed/10579918
xref: http://identifiers.org/pubmed/10851172
comment: Trk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes is slower but long lasting. Signalling from the plasma membrane is annotated here. TRK signalling leads to proliferation in some cell types and neuronal differentiation in others. Proliferation is the likely outcome of short term signalling, as observed following stimulation of EGFR (EGF receptor). Long term signalling via TRK receptors, instead, was clearly shown to be required for neuronal differentiation in response to neurotrophins.

Evidence1152
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10579926
xref: http://identifiers.org/pubmed/12123609
comment: PI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell death and survival. In addition, it may also use metabolic pathways to regulate cell survival.The PI3K/AKT pathway also affects axon diameter and branching (Marcus et al, 2002) and regulates small G proteins like RhoA (Vanhaesebroeck, B and Waterman, MD, 1999), which control the behaviour of the F-actin cytoskeleton. Moreover, through its connection with the TOR pathway, it promotes translation of a subset of mRNAs.

UniProt:P00045
type: ProteinReference
xref: UnificationXref6899
organism: BioSource1

http://identifiers.org/pubmed/15153429
type: PublicationXref
id: 15153429
author: Berezin, V
author: Bock, E
author: Kiryushko, D
db: Pubmed
title: Regulators of neurite outgrowth: role of cell adhesion molecules
source: Ann N Y Acad Sci 1014:140-54
year: 2004

UnificationXref8309
type: UnificationXref
id: P40004
db: UniProt

UnificationXref8307
type: UnificationXref
id: 742361
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=742361

UnificationXref8308
type: UnificationXref
id: REACT_22899
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22899.2

UniProt:P0C2H8
type: ProteinReference
xref: UnificationXref1459
organism: BioSource1

Evidence1167
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11431473
xref: http://identifiers.org/pubmed/2825022
xref: http://identifiers.org/pubmed/9605766
xref: http://identifiers.org/pubmed/11804589
xref: http://identifiers.org/pubmed/8288572
xref: http://identifiers.org/pubmed/17222083
xref: http://identifiers.org/pubmed/12015138
comment: The human genome includes approximately 70 genes that are predicted to encode Rho-specific GTPase Activating Proteins (RhoGAPs). As in the case of GEFs, some RhoGAPs are believed to be highly specific, whereas others are more promiscuous with respect to their target GTPases. Increasing evidence suggests that GAPs are also regulated by external cues in addition to being signal terminators leading to Rho GTPase inactivation. These proteins play important role in many Rho mediated signaling pathways. Some known GAPs include p190 A, cdGAP, ARAP3, MgcRacGAP, Chimaerin, Nadrin, TCGAP, DLC 1, 2, ArhGAP6, Myosin IXA. These and other GAPs have been implicated in many processes, such as exocytosis, endocytosis, cytokinesis, cell differentiation, migration, neuronal morphogenesis, angiogenesis and tumor suppression. Detailed annotations of the biological role of GAPs in Rho mediated signaling will be available in future releases.

UnificationXref8301
type: UnificationXref
id: 3671401
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671401

UniProt:Q12250
type: ProteinReference
xref: UnificationXref1072
organism: BioSource1

UniProt:P0C2H9
type: ProteinReference
xref: UnificationXref1461
organism: BioSource1

Evidence1168
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16190977
xref: http://identifiers.org/pubmed/1439791
xref: http://identifiers.org/pubmed/10655614
xref: http://identifiers.org/pubmed/15921909
xref: http://identifiers.org/pubmed/7824266
xref: http://identifiers.org/pubmed/10433515
xref: http://identifiers.org/pubmed/9194563
xref: http://identifiers.org/pubmed/15292224
xref: http://identifiers.org/pubmed/7543319
xref: http://identifiers.org/pubmed/10676816
xref: http://identifiers.org/pubmed/9113980
comment: GDP dissociation inhibitors or GDIs confer an additional but important layer of Rho GTPase regulation along with GEFs and GAPs. GDIs mainly inhibit the dissociation of bound guanine nucleotide (usually GDP) from their partner GTPases. So far, three human GDIs with proven biological functions have been found: RhoGDI/GDIalpha/GDI1, hematopoietic cell selective Ly/D4GDI/GDIbeta/GDI2, and Rho GDIgamma/GDI3 (DerMardirossian and Bokoch, 2005). Three specific biochemical functions of GDIs have been established: inhibiting the dissociation of GDP from Rho proteins, maintaining the GTPases in an inactive form, and preventing GTPase activation by GEFs (Olofsson, 1999). Detailed annotations of GDIs will be available in future releases.

UnificationXref8302
type: UnificationXref
id: 3671403
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671403

UniProt:P0C2H6
type: ProteinReference
xref: UnificationXref1479
organism: BioSource1

Evidence1165
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8617750
xref: http://identifiers.org/pubmed/9168115
xref: http://identifiers.org/pubmed/15534001
xref: http://identifiers.org/pubmed/16914727
xref: http://identifiers.org/pubmed/16912174
xref: http://identifiers.org/pubmed/1706616
xref: http://identifiers.org/pubmed/17545517
xref: http://identifiers.org/pubmed/11679632
xref: http://identifiers.org/pubmed/8665853
xref: http://identifiers.org/pubmed/19193720
xref: http://identifiers.org/pubmed/18721752
xref: http://identifiers.org/pubmed/12869563
xref: http://identifiers.org/pubmed/16778220
xref: http://identifiers.org/pubmed/17018285
xref: http://identifiers.org/pubmed/18653779
xref: http://identifiers.org/pubmed/17463226
xref: http://identifiers.org/pubmed/10744726
xref: http://identifiers.org/pubmed/19047365
xref: http://identifiers.org/pubmed/12807903
xref: http://identifiers.org/pubmed/10722704
xref: http://identifiers.org/pubmed/9556621
xref: http://identifiers.org/pubmed/7565730
xref: http://identifiers.org/pubmed/16978839
xref: http://identifiers.org/pubmed/16061658
xref: http://identifiers.org/pubmed/15023535
xref: http://identifiers.org/pubmed/9275162
xref: http://identifiers.org/pubmed/9135143
xref: http://identifiers.org/pubmed/10867024
xref: http://identifiers.org/pubmed/7929212
comment: ERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular ligand binding domain, a single transmembrane domain and a cytoplasmic domain which contains an active tyrosine kinase and a C-tail with multiple phosphorylation sites. At least three and possibly four splicing isoforms of ERBB4 exist that differ in their C-tail and/or the extracellular juxtamembrane regions: ERBB4 JM-A CYT1, ERBB4 JM-A CYT2 and ERBB4 JM-B CYT1 (the existence of ERBB4 JM-B CYT2 has not been confirmed). ERBB4 becomes activated by binding one of its seven ligands, three of which, HB-EGF, epiregulin EPR and betacellulin BTC, are EGF-like (Elenius et al. 1997, Riese et al. 1998), while four, NRG1, NRG2, NRG3 and NRG4, belong to the neuregulin family (Tzahar et al. 1994, Carraway et al. 1997, Zhang et al. 1997, Hayes et al. 2007). Upon ligand binding, ERBB4 forms homodimers (Sweeney et al. 2000) or it heterodimerizes with ERBB2 (Li et al. 2007). Dimers of ERBB4 undergo trans-autophosphorylation on tyrosine residues in the C-tail (Cohen et al. 1996, Kaushansky et al. 2008, Hazan et al. 1990, Li et al. 2007), triggering downstream signaling cascades. The pathway Signaling by ERBB4 only shows signaling by ERBB4 homodimers. Signaling by heterodimers of ERBB4 and ERBB2 is shown in the pathway Signaling by ERBB2. Ligand-stimulated ERBB4 is also able to form heterodimers with ligand-stimulated EGFR (Cohen et al. 1996) and ligand-stimulated ERBB3 (Riese et al. 1995). Dimers of ERBB4 with EGFR and dimers of ERBB4 with ERBB3 were demonstrated in mouse cell lines in which human ERBB4 and EGFR or ERBB3 were exogenously expressed. These heterodimers undergo trans-autophosphorylation, but their downstream signaling and physiological significance have not been studied. All splicing isoforms of ERBB4 possess two tyrosine residues in the C-tail that serve as docking sites for SH…

UniProt:P0C2H7
type: ProteinReference
xref: UnificationXref1481
organism: BioSource1

Evidence1166
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7478592
xref: http://identifiers.org/pubmed/9857026
xref: http://identifiers.org/pubmed/10559246
xref: http://identifiers.org/pubmed/8969170
xref: http://identifiers.org/pubmed/12101119
xref: http://identifiers.org/pubmed/16212495
xref: PublicationXref2233
xref: http://identifiers.org/pubmed/8276860
xref: http://identifiers.org/pubmed/9308960
xref: http://identifiers.org/pubmed/8810315
xref: http://identifiers.org/pubmed/7954831
comment: Guanine nucleotide exchange factors (GEFs) activate GTPases by enhancing the exchange of bound GDP for GTP. Much evidence points to GEFs being critical mediators of Rho GTPase activation (Schmidt and Hall, 2002). Many GEFs are known to be highly specific for a particular GTPase, e.g. Fgd1/Cdc42 and p115RhoGEF/Rho (Hart et al., 1996, Zheng et al., 1996). Others have a broader spectrum and activate several GTPases, e.g. Vav1 for Rac, Rho, and Cdc42 (Hart et al, 1994).

UnificationXref8300
type: UnificationXref
id: 3671400
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671400

UnificationXref8305
type: UnificationXref
id: 742353
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=742353

UnificationXref8306
type: UnificationXref
id: REACT_22644
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22644.2

Evidence1169
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10655614
xref: http://identifiers.org/pubmed/12471028
xref: http://identifiers.org/pubmed/15921909
xref: http://identifiers.org/pubmed/9194563
xref: http://identifiers.org/pubmed/10676816
comment: GDIs sequester the inactive GTPases, preventing the dissociation of GDP and interactions with regulatory and effector molecules. They maintain Rho GTPases as soluble cytosolic proteins by forming high affinity complexes. In these complexes, the geranylgeranyl membrane targeting moiety present at the C terminus of the Rho GTPases is shielded from the solvent by its insertion into the hydrophobic pocket formed by the immunoglobulin like beta sandwich of the GDI (DerMardirossian and Bokoch, 2005). Rho proteins, when released from the sequestering cytosolic GDIs, insert into the lipid bilayer of the plasma membrane with their isoprenylated C termini. The membrane bound GEFs activate these free RhoGTPases and thereby trigger the downstream signaling events via respective effector proteins on the membrane (Robbe et al., 2003). Detailed annotation of the activities of farnesyltransferase / geranylgeranyltransferases on prenylation of Rho GTPases thereby enabling their subsequent localization to plasma membrane will be available in future releases.

UnificationXref8303
type: UnificationXref
id: REACT_134481
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134481.5

UnificationXref8304
type: UnificationXref
id: CHEBI:16082
db: ChEBI

Evidence1160
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: ERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated tyrosine residues in the C-tail of ERBB3 (Y1054, Y1197, Y1222, Y1224, Y1276 and Y1289) and ERBB4 CYT1 isoforms (Y1056 in JM-A CYT1 isoform and Y1046 in JM-B CYT1 isoform). Regulatory subunit p85 subsequently recruits catalytic subunit p110 of PI3K, resulting in the formation of active PI3K, conversion of PIP2 to PIP3, and PIP3-mediated activation of AKT signaling (Junttila et al. 2009, Kainulainen et al. 2000). Heterodimers of ERBB2 and EGFR recruit PI3K indirectly, through GRB2:GAB1 complex (Jackson et al. 2004), which again leads to PIP3-mediated activation of AKT signaling.

http://identifiers.org/pubmed/11124962
type: PublicationXref
id: 11124962
author: Wilson, GM
author: Brewer, G
author: Chuang, Ky
author: Sutphen, K
db: Pubmed
title: Folding of A+U-rich RNA elements modulates AUF1 binding. Potential roles in regulation of mRNA turnover
source: J Biol Chem 276:8695-704
year: 2001

Evidence1164
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: The CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen et al. 1996). Binding of PIK3R1 to CYT1 isoforms of ERBB4 is followed by recruitment of the p110 catalytic subunit of PI3K (PIK3CA), leading to assembly of an active PI3K complex that converts PIP2 to PIP3 and activates AKT signaling (Kainulainen et al. 2000).

Evidence1163
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: All splicing isoforms of ERBB4 possess two tyrosine residues in the C-tail that serve as docking sites for SHC1 (Kaushansky et al. 2008, Pinkas-Kramarski et al. 1996, Cohen et al. 1996). Once bound to ERBB4, SHC1 becomes phosphorylated on tyrosine residues by the tyrosine kinase activity of ERBB4, which enables it to recruit the complex of GRB2 and SOS1, resulting in the guanyl-nucleotide exchange on RAS and activation of RAF and MAP kinase cascade (Kainulainen et al. 2000).

Evidence1162
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: ERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR family members, a single transmembrane domain, and an intracellular domain consisting of an active kinase and a C-tail with multiple tyrosine phosphorylation sites. Inactive ERBB2 is associated with a chaperone heat shock protein 90 (HSP90) and its co-chaperone CDC37 (Xu et al. 2001, Citri et al. 2004, Xu et al. 2005). In addition, ERBB2 is associated with ERBB2IP (also known as ERBIN or LAP2), a protein responsible for proper localization of ERBB2. In epithelial cells, ERBB2IP restricts expression of ERBB2 to basolateral plasma membrane regions (Borg et al. 2000). ERBB2 becomes activated by forming a heterodimer with another ligand-activated EGFR family member, either EGFR, ERBB3 or ERBB4, which is accompanied by dissociation of chaperoning proteins HSP90 and CDC37 (Citri et al. 2004), as well as ERBB2IP (Borg et al. 2000) from ERBB2. ERBB2 heterodimers function to promote cell proliferation, cell survival and differentiation, depending on the cellular context. ERBB2 can also be activated by homodimerization when it is overexpressed, in cancer for example. In cells expressing both ERBB2 and EGFR, EGF stimulation of EGFR leads to formation of both ERBB2:EGFR heterodimers (Wada et al. 1990, Karunagaran et al. 1996) and EGFR homodimers. Heterodimers of ERBB2 and EGFR trans-autophosphorylate on twelve tyrosine residues, six in the C-tail of EGFR and six in the C-tail of ERBB2 - Y1023, Y1139, Y1196, Y1221, Y1222 and Y1248 (Margolis et al. 1989, Hazan et al. 1990,Walton et al. 1990, Helin et al. 1991, Ricci et al. 1995, Pinkas-Kramarski 1996). Phosphorylated tyrosine residues in the C-tail of EGFR and ERBB2 serve as docking sites for downstream signaling molecules. Three key signaling pathways activated by ERBB2:EGFR heterodimers are RAF/MAP kinase cascade, PI3K-induced AKT …

Evidence1161
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Activation of PLCG1 signaling is observed only in the presence of ERBB2:EGFR heterodimers, with PLCG1 binding to phosphorylated tyrosine Y992 and Y1173 in the C-tail of EGFR (Chattopadhyay et al. 1999), and potentially Y1023 in the C-tail of ERBB2 (Fazioli et al. 1991, Cohen et al. 1996).

http://identifiers.org/pubmed/20861159
type: PublicationXref
id: 20861159
author: Nilius, B
author: Colsoul, B
author: Gees, M
db: Pubmed
title: The role of transient receptor potential cation channels in Ca2+ signaling
source: Cold Spring Harb Perspect Biol 2:a003962
year: 2010

UnificationXref8318
type: UnificationXref
id: 3671410
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671410

UniProt:Q12289
type: ProteinReference
xref: UnificationXref3405
organism: BioSource1

UnificationXref8319
type: UnificationXref
id: REACT_145197
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145197.5

UnificationXref8314
type: UnificationXref
id: 741437
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=741437

UnificationXref8315
type: UnificationXref
id: REACT_22968
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22968.1

UnificationXref8316
type: UnificationXref
id: 914003
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=914003

YLL009C
type: ProteinReference
name: UniProt:Q12287 COX17
name: L1343
name: COX17
xref: UnificationXref636
comment: FUNCTION Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX.SIMILARITY Belongs to the COX17 family.
organism: BioSource1

UnificationXref8317
type: UnificationXref
id: REACT_26828
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26828.2

Evidence1176
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12588974
xref: http://identifiers.org/pubmed/18814923
xref: http://identifiers.org/pubmed/16102047
xref: http://identifiers.org/pubmed/7559569
xref: http://identifiers.org/pubmed/19212140
comment: The G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay technologies that measure intracellular calcium. The G12/13 family are best known for their involvement in the processes of cell proliferation and morphology, such as stress fiber and focal adhesion formation. Interactions with Rho guanine nucleotide exchange factors (RhoGEFs) are thought to mediate many of these processes. (Buhl et al.1995, Sugimoto et al. 2003). Activation of Rho or the regulation of events through Rho is often taken as evidence of G12/13 signaling. Receptors that are coupled with G12/13 invariably couple with one or more other G protein subtypes, usually Gq.

UnificationXref8310
type: UnificationXref
id: 3671408
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671408

Evidence1177
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17041586
xref: http://identifiers.org/pubmed/17916723
comment: PI3K gamma (PI3KG) is a heterodimer consisting of a p110 catalytic subunit associated with a regulatory p101 or p84 subunit. PI3KG is most highly expressed in neutrophils, where the p101 form predominates (approximately 95%). G beta:gamma recruits PI3KG to the plasma membrane, both activating PI3KG and providing access to its substrate PIP2, which is converted to PIP3.

UnificationXref8311
type: UnificationXref
id: 3671412
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671412

Evidence1178
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18834311
comment: The classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known that Gbeta/gamma subunits can directly modulate many effectors, including some also regulated by G alpha.

UnificationXref8312
type: UnificationXref
id: REACT_130822
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130822.5

UniProt:Q02979
type: ProteinReference
xref: UnificationXref4118
organism: BioSource1

Evidence1179
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18488142
xref: http://identifiers.org/pubmed/19935667
xref: http://identifiers.org/pubmed/15251227
xref: http://identifiers.org/pubmed/18515421
xref: http://identifiers.org/pubmed/18240029
xref: http://identifiers.org/pubmed/12040175
xref: http://identifiers.org/pubmed/13679574
comment: G protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it has become clear that this greatly oversimplifies the complexities of GPCR signaling (see Gurevich & Gurevich, 2008). The beta:gamma G-protein dimer is also involved in downstream signaling (Smrcka, 2008), and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events (Kristiansen 2004), using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK.

UnificationXref8313
type: UnificationXref
id: CHEBI:16264
db: ChEBI

Evidence1173
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12036966
comment: The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated.

2,6-diaminohexanoic acid
type: SmallMoleculeReference
name: Lysine acid
name: L-Lysine [ChEBI:18019]
name: L-Lysine
xref: UnificationXref5926

Evidence1172
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2265
xref: http://identifiers.org/pubmed/15769620
xref: http://identifiers.org/pubmed/15798894
comment: Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP. Some PDEs are cAMP selective (PDE4, 7 and 8), some cGMP selective (PDE5, 6 and 9) while others can hydrolyse cAMP and cGMP (PDE1, 2, 3, 10 and 11). PDEs are important as drug targets: Sildenafil (Viagra) is an inhibitor of PDE5; Cilostazol (Pletal) inhibits PDE3, increasing the flexibility of erythrocytes.

Evidence1175
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12101119
xref: http://identifiers.org/pubmed/16212495
xref: http://identifiers.org/pubmed/8276860
xref: http://identifiers.org/pubmed/9308960
xref: http://identifiers.org/pubmed/8810315
comment: Guanine nucleotide exchange factors (GEFs) activate GTPases by enhancing the exchange of bound GDP for GTP. Much evidence points to GEFs being critical mediators of Rho GTPase activation (Schmidt and Hall, 2002). Many GEFs are known to be highly specific for a particular GTPase, e.g. Fgd1/Cdc42 and p115RhoGEF/Rho (Hart et al., 1996, Zheng et al., 1996). Others have a broader spectrum and activate several GTPases, e.g. Vav1 for Rac, Rho, and Cdc42 (Hart et al, 1994).

UnificationXref8320
type: UnificationXref
id: 3673530
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673530

Evidence1174
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9296496
xref: http://identifiers.org/pubmed/16102047
xref: http://identifiers.org/pubmed/19212139
comment: The classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides a path to calcium-regulated kinases and phosphatases, GEFs, MAP kinase cassettes and other proteins that mediate cellular responses ranging from granule secretion, integrin activation, and aggregation in platelets. Gq participates in many other signalling events including direct interaction with RhoGEFs that stimulate RhoA activity and inhibition of PI3K. Both in vitro and in vivo, the G-protein Gq seems to be the predominant mediator of the activation of platelets.

Evidence1171
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15630019
xref: http://identifiers.org/pubmed/10445846
xref: http://identifiers.org/pubmed/14521508
xref: http://identifiers.org/pubmed/12101119
xref: http://identifiers.org/pubmed/16212495
xref: http://identifiers.org/pubmed/12618308
xref: http://identifiers.org/pubmed/16757309
comment: The Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as binary switches controlling a variety of biological processes. They perform this function by cycling between active GTP-bound and inactive GDP-bound conformations. Mammalian Rho GTPases include RhoA, RhoB and RhoC (Rho proteins), Rac1 3 (Rac proteins), Cdc42, TC10, TCL, Wrch1, Chp/Wrch2, RhoD and RhoG, to name some. The family also includes RhoH and Rnd1-3, which lack GTPase activity and are predicted to exist in a constitutively active state. Members of the Rho family have been identified in all eukaryotes. Including the atypical RHOBTB1-3 and RHOT1-2 proteins, 24 Rho family members have been identified in mammals (Jaffe and Hall, 2005; Bernards, 2005; Ridley, 2006). Among Rho GTPases, RhoA, Rac1 and Cdc42 have been most extensively studied. These proteins are best known for their ability to induce dynamic rearrangements of the plasma membrane-associated actin cytoskeleton (Aspenstrom et al, 2004; Murphy et al, 1999; Govek et al, 2005). Beyond this function, Rho GTPases also regulate actomyosin contractility and microtubule dynamics. Rho mediated effects on transcription and membrane trafficking are believed to be secondary to these functions. At the more macroscopic level, Rho GTPases have been implicated in many important cell biological processes, including cell growth control, cytokinesis, cell motility, cell cell and cell extracellular matrix adhesion, cell transformation and invasion, and development (Govek et al., 2005). The illustration below lists Rho GTPase effectors implicated in actin and microtubule dynamics (courtesy: Govek et al., 2005, Genes and Development, CSHL Press). Detailed annotations of various biological processes regulated by Rho GTPases will be available in future releases.

Evidence1170
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16212495
xref: http://identifiers.org/pubmed/17222083
xref: http://identifiers.org/pubmed/9308960
comment: The cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the cytoplasm, (2) guanine nucleotide exchange factors or GEFs, which destabilize the interaction between Rho proteins and their bound nucleotide, the net result of which is the exchange of bound GDP for the more abundant GTP, and (3) GTPase Activating Proteins or GAPs, which stimulate the low intrinsic GTP hydrolysis activity of Rho family members, thus promoting their inactivation. GDIs, GEFs, and GAPs are themselves subject to tight regulation, and the overall level of Rho activity reflects the balance of their activities. In their active GTP-bound state, Rho family members have the ability to interact with a large variety of so-called effector proteins. By changing the subcellular localization of effectors, by altering their enzymatic properties, or by directing the formation of specific effector complexes, members of the Rho family mediate their various effects. This Rho GTPase cycle is diagrammed in the figure below. External or internal cues promote the release of Rho GTPases from the inhibitory complex (1) which allows them to associate with the plasma membrane (2) where they are activated by GEFs (3) and can signal to effector proteins. Then, GAPs inactivate the GTPases by accelerating the intrinsic GTPase activity, leading to the GDP bound form (4). Once again, the GDI molecules stabilize the inactive GDP bound form in the cytoplasm, waiting for further instructions (5). (Figure and text from Tcherkezian and Lamarche Vane, 2007).

Fumaric acid
type: SmallMoleculeReference
name: ChEBI:18012 Fumaric acid
name: Trans-butenedioic acid
xref: UnificationXref4900

UnificationXref8329
type: UnificationXref
id: 3671445
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671445

UnificationXref8327
type: UnificationXref
id: REACT_164213
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_164213.1

UnificationXref8328
type: UnificationXref
id: 3648344
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648344

UnificationXref8325
type: UnificationXref
id: 3648343
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648343

UnificationXref8326
type: UnificationXref
id: 3632879
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3632879

http://identifiers.org/pubmed/17555404
type: PublicationXref
id: 17555404
author: Alp, NJ
author: Schmidt, TS
db: Pubmed
title: Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
source: Clin Sci (Lond) 113:47-63
year: 2007

Evidence1189
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/22094272
xref: http://identifiers.org/pubmed/11031247
xref: http://identifiers.org/pubmed/22094269
xref: http://identifiers.org/pubmed/19566487
xref: http://identifiers.org/pubmed/20533886
xref: http://identifiers.org/pubmed/21886182
comment: This black box event represents the non-WNT-specific ER-to-Golgi trafficking step of protein secretion (reviewed in Dancourt and Barlowe, 2010; Lippincott Schwatz et al, 2000; for more details, please refer to the pathway "ER to Golgi transport"). Two recent screens in Drosophila have identified members of the p24 family as WNT-specific regulators of ER-to-Golgi transport, although the details have not been elucidated (Port et al, 2011; Buechling et al, 2011; reviewed in Strating and Martens, 2009). Depletion of the Drosophila p24 protein Opossum causes accumulation of WNT ligand in the ER, suggesting a role for Opm in ER-to-Golgi transport of WNTs. WNT-dependent reporter activity was reduced in HEK293 cells that were depleted for the human p24 homologue TMED5, supporting a conserved role for these proteins in WNT signaling (Buechling et al, 2011; reviewed in Palmer et al, 2012).

UnificationXref8323
type: UnificationXref
id: 400431
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=400431

UnificationXref8324
type: UnificationXref
id: REACT_19561
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19561.2

UniProt:Q12271
type: ProteinReference
xref: UnificationXref3081
organism: BioSource1

Evidence1187
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10202136
xref: http://identifiers.org/pubmed/16902930
xref: http://identifiers.org/pubmed/18043707
comment: G protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors in humans, accounting for more than 1% of the protein-coding capacity of the human genome. All known GPCRs share a common architecture of seven membrane-spanning helices connected by intra- and extracellular loops. The extracellular loops contain two highly-conserved cysteine residues that form disulphide bonds to stabilize the structure of the receptor. They recognize diverse messengers such as light, odorants, small molecules, hormones and neurotransmitters. Most GPCRs act as guanine nucleotide exchange factors; activated by ligand binding, they promote GDP-GTP exchange on associated heterotrimeric guanine nucleotide-binding (G) proteins. There are two models for GPCR-G Protein interactions: 1) ligand-GPCR binding first, then binding to G Proteins; 2) "Pre-coupling" of GPCRs and G Proteins before ligand binding (review Oldham WM and Hamm HE, 2008). These in turn activate effector enzymes or ion channels. GPCRs are involved in a range of physiological roles which include the visual sense, smell, behavioural regulation, functions of the autonomic nervous system and regulation of the immune system and inflammation. GPCRs are divided into 6 classes based on sequence homology and functional similarity; the main mammalian families are classes A/1-C/3; Class A/1 (Rhodopsin-like) Class B/2 (Secretin receptor family) Class C/3 (Metabotropic glutamate/pheromones) Class D/4 (fungal mating pheromone receptors) Class E/5 (cAMP receptors) Class F/6 (Frizzled/Smoothened) Here, those Class A/1 (Rhodopsin-like) receptors that bind peptide ligands have been annotated. The binding events mediated by other classes of receptors, as well as the downstream events triggered by receptor-ligand interactions will be annotated in future releases of Reactome.

UnificationXref8321
type: UnificationXref
id: REACT_132866
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132866.5

Evidence1188
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17397399
xref: http://identifiers.org/pubmed/17117926
xref: http://identifiers.org/pubmed/8167409
xref: http://identifiers.org/pubmed/12717451
xref: http://identifiers.org/pubmed/22108505
comment: All WNT ligands are predicted to be highly glycosylated. By similarity with WNT ligands in mouse, human WNTs are believed to undergo N-linked glycosylation at multiple asparagine residues and this glycosylation is critical for their secretion (Smolich et al, 1993; Willert et al, 2003, Komekado et al, 2006; Kurayoshi et al, 2007). The mechanism of N-linked glycosylation is not shown here. For a more detailed description, please refer to pathway "Asparagine N-linked glycosylation".

UnificationXref8322
type: UnificationXref
id: CHEBI:16196
db: ChEBI

Evidence1186
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7491953
xref: http://identifiers.org/pubmed/17698287
xref: http://identifiers.org/pubmed/10413847
comment: Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17.Gastrin gene expression is upregulated in both a number of pre-malignant conditions and in established cancer through a variety of mechanisms. Depending on the tissue where it is expressed and the level of expression, differential processing of the polypeptide product leads to the production of different biologically active peptides. In turn, acting through the classical gastrin cholecystokinin B receptor CCK-BR, its isoforms and alternative receptors, these peptides trigger signalling pathways which influence the expression of downstream genes that affect cell survival, angiogenesis and invasion (Wank 1995, de Weerth et al. 1999, Grabowska & Watson 2007)

UnificationXref8331
type: UnificationXref
id: 3671447
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671447

Evidence1185
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16816139
xref: http://identifiers.org/pubmed/20398727
comment: Gastrin, through the action of diacylglycerol produced from downstream G alpha (q) events, transactivates EGFR via a PKC-mediated pathway by activation of MMP3 (Matrix Metalloproteinase 3) which allows formation of mature HBEGF (heparin-binding epidermal growth factor) by cleaving pro-HBEGF. Mature HBEGF is then free to bind the EGFR, resulting in EGFR activation (Dufresne et al. 2006, Liebmann 2011).

UnificationXref8330
type: UnificationXref
id: 3671446
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671446

NADP+
type: SmallMoleculeReference
name: TPN
name: NADP+ [ChEBI:18009]
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref71

Evidence1184
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9218123
xref: http://identifiers.org/pubmed/16612131
xref: http://identifiers.org/pubmed/9422713
comment: Opioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as the enkephalins, the endorphins or the dynorphins. Opioids possess powerful analgesic and sedative effects, and are widely used as pain-killers. Their main side-effect is the rapid establishment of a strong addiction. Opioids receptors are G-protein coupled receptors (GPCR). There are four classes of receptors: mu (MOR), kappa (KOR) and delta (DOR), and the nociceptin receptor (NOP).

Evidence1183
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14744247
xref: http://identifiers.org/pubmed/2908293
comment: Dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation DARPP-32 phosphorylation provides a mechanism for integrating information arriving at dopaminoceptive neurons, in multiple brain regions, via a variety of neurotransmitters, neuromodulators, neuropeptides, and steroid hormones. Activation of PKA or PKG stimulates DARPP-32 phosphorylation at Thr34, converting DARPP-32 into a potent inhibitor of protein phosphatase-1 (PP-1). DARPP-32 is also phosphorylated at Thr75 by Cdk5, converting DARPP-32 into an inhibitor of PKA. Thus, DARPP-32 has the unique property of being a dual-function protein, acting either as an inhibitor of PP-1 or of PKA.

Evidence1182
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9218123
xref: http://identifiers.org/pubmed/9422713
comment: When dissociated Galpha-GTP and Gbeta-gamma can activate or inhibit different signalling cascades and effector proteins. The precise pathways depends on the identity of the alpha and beta/gamma subtypes.

Evidence1181
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9218123
xref: http://identifiers.org/pubmed/1335363
xref: http://identifiers.org/pubmed/16183910
comment: The phospholipase C (PLC) family of enzymes is both diverse and complex. The isoforms beta, gamma and delta (each have subtypes) make up the members of this family. PLC hydrolyzes phosphatidylinositol bisphosphate (PIP2) into two second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 mobilizes intracellular calcium stores while DAG activates protein kinase C isoforms which are involved in regulatory functions.

3-phenyl-2-oxopropanoate
type: SmallMoleculeReference
name: keto-phenylpyruvate
name: keto-phenylpyruvate [ChEBI:18005]
name: 3-(4-hydroxyphenyl)pyruvate
xref: UnificationXref2194

Evidence1180
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16076488
xref: http://identifiers.org/pubmed/11162741
xref: http://identifiers.org/pubmed/17697045
xref: http://identifiers.org/pubmed/18083096
comment: Calcium, as the ion Ca2+, is essential in many biological processes. The majority of Ca2+ in many organisms is bound to phosphates which form skeletal structures and also buffer Ca2+ levels in extracellular fluids (typically 1 millimolar). Intracellular free Ca2+, by contrast, is 10,000 times lower than the outside of the cell (typically 10 micromolar). This concentration gradient is used to import Ca2+ into cells where it acts as a second messenger.

UniProt:P36973
type: ProteinReference
xref: UnificationXref5197
organism: BioSource1

http://identifiers.org/pubmed/15893380
type: PublicationXref
id: 15893380
author: Jackowski, S
author: Zhang, YM
author: Rock, CO
author: Leonardi, R
db: Pubmed
title: Coenzyme A: back in action
source: Prog Lipid Res 44:125-53
year: 2005

http://identifiers.org/pubmed/17635959
type: PublicationXref
id: 17635959
author: Blodgett, DM
author: Karim, P
author: Carruthers, A
author: De Zutter, JK
author: Levine, KB
db: Pubmed
title: Structural basis of GLUT1 inhibition by cytoplasmic ATP
source: J Gen Physiol 130:157-68
year: 2007

http://identifiers.org/pubmed/9083049
type: PublicationXref
id: 9083049
author: Lee, PT
author: Shepherd, JA
author: Tzagoloff, A
author: Myles, DC
author: Clarke, CF
author: Shtanko, A
author: Barkovich, RJ
db: Pubmed
title: Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis
source: J Biol Chem 272:9182-8
year: 1997

GABA synthesis, release, reuptake and degradation
type: Pathway
data source: Provenance1
pathway component: REACT 141218.5
evidence: Evidence55
xref: UnificationXref483
xref: UnificationXref482
pathway order: PathwayStep48
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/21682741
type: PublicationXref
id: 21682741
author: Minnicozzi, M
author: Fenton, MJ
author: Sawyer, RT
db: Pubmed
title: Innate immunity in allergic disease
source: Immunol Rev 242:106-27
year: 2011

UniProt:Q12213
type: ProteinReference
xref: UnificationXref1576
organism: BioSource1

http://identifiers.org/pubmed/12438414
type: PublicationXref
id: 12438414
author: Michael, WM
author: Van Hatten, RA
author: Holway, AH
author: Tutter, AV
author: Khederian, AM
author: Walter, JC
db: Pubmed
title: The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication.
source: J Cell Biol 159:541-7
year: 2002

http://identifiers.org/pubmed/19428801
type: PublicationXref
id: 19428801
author: Buddhala, C
author: Wu, Jer-Yuarn
author: Hsu, CC
db: Pubmed
title: A novel mechanism for GABA synthesis and packaging into synaptic vesicles
source: Neurochem Int 55:9-12
year: 2009

UniProt:Q12236
type: ProteinReference
xref: UnificationXref2080
organism: BioSource1

http://identifiers.org/pubmed/11752427
type: PublicationXref
id: 11752427
author: McCarthy, DB
author: Stoops, JK
author: O'Connor, CM
author: Reed, LJ
author: Zhou, ZH
db: Pubmed
title: The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes.
source: Proc Natl Acad Sci U S A 98:14802-7
year: 2001

http://identifiers.org/pubmed/16854592
type: PublicationXref
id: 16854592
author: Wu, Y
author: Feder, JN
author: Cheng, D
author: Mintier, GA
author: Tamura, JK
author: Chu, CH
author: Harpel, MR
author: Locke, GA
author: An, Y
author: Cook, JW
author: Chen, L
db: Pubmed
title: Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes
source: Protein Expr Purif 51:11-21
year: 2007

CHEBI:71956
type: SmallMoleculeReference
name: CHEBI:71956 [ChEBI:71956]
xref: UnificationXref2122

http://identifiers.org/pubmed/10411507
type: PublicationXref
id: 10411507
author: McGarry, TJ
author: Zou, H
author: Bernal, T
author: Kirschner, MW
db: Pubmed
title: Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis
source: Science 285:418-22
year: 1999

http://identifiers.org/pubmed/9593753
type: PublicationXref
id: 9593753
author: Jackowski, S
author: Lykidis, A
author: Murti, KG
db: Pubmed
title: Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase
source: J Biol Chem 273:14022-9
year: 1998

Fc epsilon receptor (FCERI) signaling
type: Pathway
data source: Provenance1
pathway component: Role of LAT2/NTAL/LAB on calcium mobilization
pathway component: REACT 168266.1
pathway component: FCERI mediated MAPK activation
evidence: Evidence1348
xref: UnificationXref9330
xref: RelationshipXref1131
xref: UnificationXref9329
pathway order: PathwayStep1351
pathway order: PathwayStep1348
pathway order: PathwayStep1350
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/19385603
type: PublicationXref
id: 19385603
author: Urzica, Eugen
author: Mühlenhoff, Ulrich
author: Lill, R
author: Pierik, Antonio J
db: Pubmed
title: Crucial role of conserved cysteine residues in the assembly of two iron-sulfur clusters on the CIA protein Nar1
source: Biochemistry 48:4946-58
year: 2009

UniProt:Q12200
type: ProteinReference
xref: UnificationXref3255
organism: BioSource1

UniProt:Q3E7X9
type: ProteinReference
xref: UnificationXref1631
organism: BioSource1

http://identifiers.org/pubmed/9124315
type: PublicationXref
id: 9124315
author: Huang, MY
author: Young, JD
author: Yao, SY
author: Ritzel, MW
author: Elliott, JF
author: Cass, CE
db: Pubmed
title: Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)
source: Am J Physiol Cell Physiol 272:707-714
year: 1997

di-retinoid-pyridinium-ethanolamine
type: SmallMoleculeReference
name: di-retinoid-pyridinium-ethanolamine [ChEBI:71980]
name: A2E
xref: UnificationXref2224

http://identifiers.org/pubmed/15157936
type: PublicationXref
id: 15157936
author: Bertinato, J
author: L'Abbé, MR
db: Pubmed
title: Maintaining copper homeostasis: regulation of copper-trafficking proteins in response to copper deficiency or overload
source: J Nutr Biochem 15:316-22
year: 2004

http://identifiers.org/pubmed/20147624
type: PublicationXref
id: 20147624
author: Pellegrini-Calace, M
author: Oliva, R
author: Calamita, G
author: Thornton, JM
db: Pubmed
title: Electrostatics of aquaporin and aquaglyceroporin channels correlates with their transport selectivity
source: Proc Natl Acad Sci U S A 107:4135-40
year: 2010

Uroporphyrinogen I
type: SmallMoleculeReference
name: Uroporphyrinogen I [ChEBI:9904]
xref: UnificationXref6346

http://identifiers.org/pubmed/16533814
type: PublicationXref
id: 16533814
author: Kang, KR
author: McPhie, P
author: Bell, JK
author: Park, MH
author: Wolff, EC
author: Kim, YS
db: Pubmed
title: Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected].
source: J Biol Chem 281:13217-25
year: 2006

http://identifiers.org/pubmed/10212249
type: PublicationXref
id: 10212249
author: Sondermann, P
author: Steegborn, C
author: Wahl, MC
author: Huber, R
author: Marinkovic, S
author: Jacob, U
author: Worbs, M
author: Clausen, T
db: Pubmed
title: Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration
source: J Biol Chem 274:12675-84
year: 1999

http://identifiers.org/pubmed/20952656
type: PublicationXref
id: 20952656
author: Fitzgerald, Kevin
author: Palnitkar, Maya
author: Kwon, Hyock Joo
author: Horton, JD
author: Deisenhofer, Johann
author: Henry, Lisa
author: Kim, Chai-Wan
author: McKean, William B
author: Moon, YA
author: Colbert, Christopher L
db: Pubmed
title: Crystal structure of Spot 14, a modulator of fatty acid synthesis
source: Proc. Natl. Acad. Sci. U.S.A. 107:18820-5
year: 2010

http://identifiers.org/pubmed/15581572
type: PublicationXref
id: 15581572
author: Xia, Z
author: Massiah, M A
author: Mildvan, A S
author: Kang, L-W
author: Gabelli, S B
author: Bianchet, M A
author: Amzel, L Mario
author: Azurmendi, H F
author: Legler, P M
author: Saraswat, V
db: Pubmed
title: Structures and mechanisms of Nudix hydrolases
source: Arch. Biochem. Biophys. 433:129-43
year: 2005

http://identifiers.org/pubmed/21865594
type: PublicationXref
id: 21865594
author: Riemer, J
author: Suzuki, Y
author: Keller, S
author: Longen, S
author: Fiedler, S
author: Klöppel, C
author: Petrungaro, C
author: Kojer, K
db: Pubmed
title: Mia40-dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosol
source: Mol Biol Cell 22:3749-57
year: 2011

http://identifiers.org/pubmed/16856888
type: PublicationXref
id: 16856888
author: Tomer, A
author: Deutsch, VR
db: Pubmed
title: Megakaryocyte development and platelet production
source: Br J Haematol 134:453-66
year: 2006

UniProt:P07991
type: ProteinReference
xref: UnificationXref5800
organism: BioSource1

UniProt:P34087
type: ProteinReference
xref: UnificationXref2321
organism: BioSource1

UniProt:Q3E731 COX19
type: ProteinReference
name: COX19
name: YLL018C-A
xref: UnificationXref639
comment: FUNCTION Required for the assembly of mitochondrial cytochrome c oxidase.MISCELLANEOUS Present with 5750 molecules/cell in log phase SD medium.SIMILARITY Belongs to the COX19 family.SIMILARITY Contains 1 CHCH domain.
organism: BioSource1

http://identifiers.org/pubmed/18070913
type: PublicationXref
id: 18070913
author: van der Laan, M
author: Pfanner, N
author: Rehling, P
author: Wiedemann, N
author: Hutu, DP
db: Pubmed
title: Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain
source: J Cell Biol 179:1115-22
year: 2007

http://identifiers.org/pubmed/17380317
type: PublicationXref
id: 17380317
author: Hussain, K
author: Richardson, CC
author: Christie, MR
author: Jones, PM
author: Löbner, K
author: Clark, A
author: Persaud, S
author: Boehm, A
db: Pubmed
title: Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development
source: Diabetologia 50:1000-5
year: 2007

http://identifiers.org/pubmed/9799232
type: PublicationXref
id: 9799232
author: Wagner, H
author: Mischak, H
author: Sparwasser, T
author: Lipford, GB
author: Schmid, R
author: Heeg, K
author: Miethke, T
author: Hacker, H
author: Liptay, S
db: Pubmed
title: CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
source: EMBO J 17:6230-40
year: 1998

http://identifiers.org/pubmed/9799231
type: PublicationXref
id: 9799231
author: Guillemot, JC
author: Chavrier, P
author: Montcourrier, P
author: Massol, P
db: Pubmed
title: Fc receptor-mediated phagocytosis requires CDC42 and Rac1
source: EMBO J 17:6219-29
year: 1998

http://identifiers.org/pubmed/19010255
type: PublicationXref
id: 19010255
author: Neu-Yilik, G
author: Kulozik, AE
db: Pubmed
title: NMD: multitasking between mRNA surveillance and modulation of gene expression
source: Adv Genet 62:185-243
year: 2008

http://identifiers.org/pubmed/7685356
type: PublicationXref
id: 7685356
author: Weiner, KX
author: Maley, F
author: Weiner, RS
author: Maley, GF
db: Pubmed
title: Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli
source: J Biol Chem 268:12983-9
year: 1993

UniProt:Q3E754
type: ProteinReference
xref: UnificationXref1715
organism: BioSource1

http://identifiers.org/pubmed/12040175
type: PublicationXref
id: 12040175
author: Iyengar, R
author: Ram, PT
author: Neves, SR
db: Pubmed
title: G protein pathways
source: Science 296:1636-9
year: 2002

UniProt:Q3E757
type: ProteinReference
xref: UnificationXref1415
organism: BioSource1

UniProt:P51601
type: ProteinReference
xref: UnificationXref4805
organism: BioSource1

http://identifiers.org/pubmed/1907934
type: PublicationXref
id: 1907934
author: Taylor, MW
author: Feng, G
db: Pubmed
title: Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism
source: FASEB J 5:2516-2522
year: 1991

Evidence1220
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Resolution of AP sites can occur through the single-nucleotide replacement pathway or through the multiple-nucleotide patch replacement pathway.

UnificationXref8288
type: UnificationXref
id: 3671390
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671390

Evidence1221
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11937636
xref: http://identifiers.org/pubmed/10583946
comment: Of the three major pathways involved in the repair of nucleotide damage in DNA, base excision repair (BER) involves the greatest number of individual enzymatic activities. This is the consequence of the numerous individual glycosylases, each of which recognizes and removes a specific modified base(s) from DNA. BER is responsible for the repair of the most prevalent types of DNA lesions, alterations, which arise intracellularly as a consequence of normal mitochondrial metabolism or by oxidative free radicals resulting from ionizing radiation, lipid peroxidation or activated phagocytic cells. BER is a two-step process initiated by one of the DNA glycosylases that recognizes a specific modified base(s) and removes that base through the catalytic cleavage of the glycosylic bond, leaving an abasic site without disruption of the phosphate-sugar DNA backbone. Subsequently, abasic sites are resolved by a series of enzymes that cleave the backbone, synthesize the replacement residue(s), and ligate the DNA strand. BER may occur by either a single-nucleotide replacement pathway or a multiple-nucleotide patch replacement pathway, depending on the structure of the terminal sugar phosphate residue. The glycosylases found in human cells recognize "foreign adducts" and not standard functional modifications such as DNA methylation.

UnificationXref8289
type: UnificationXref
id: 3671392
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671392

Evidence1222
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'damaged DNA substrate ', and 1 molecule of 'HREV1 protein' are present. At the end of this reaction, 1 molecule of 'HREV1:damaged DNA template complex' is present. This reaction takes place in the 'nucleus'.

Evidence1223
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'HREV1:damaged DNA template complex' is present. At the end of this reaction, 1 molecule of 'HREV1:lesioned DNA template with misinserted bases' is present. This reaction takes place in the 'nucleus' and is mediated by the 'DNA-directed DNA polymerase activity' of 'HREV1:damaged DNA template complex'.

Evidence1224
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'HREV1:lesioned DNA template with misinserted bases' is present. At the end of this reaction, 1 molecule of 'HREV1 protein', and 1 molecule of 'Elongated DNA template with bypassed lesion' are present. This reaction takes place in the 'nucleus' and is mediated by the 'DNA-directed DNA polymerase activity' of 'HREV1:lesioned DNA template with misinserted bases'.

Evidence1225
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10536157
xref: http://identifiers.org/pubmed/10760286
comment: HREV1 encodes a template dependent dCMP transferase activity that can insert a C residue opposite an abasic site.

Evidence1226
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'damaged DNA substrate ', and 1 molecule of 'Pol eta protein' are present. At the end of this reaction, 1 molecule of 'Pol eta:damaged DNA template complex' is present. This reaction takes place in the 'nucleus'.

Evidence1227
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'Pol eta:damaged DNA template complex' is present. At the end of this reaction, 1 molecule of 'Pol eta:lesioned DNA template inserted with correct base complement' is present. This reaction takes place in the 'nucleus' and is mediated by the 'eta DNA polymerase activity' of 'Pol eta:damaged DNA template complex'.

Evidence1228
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'Pol eta:lesioned DNA template inserted with correct base complement' is present. At the end of this reaction, 1 molecule of 'Pol eta protein', and 1 molecule of 'Elongated DNA template with bypassed lesion' are present. This reaction takes place in the 'nucleus' and is mediated by the 'eta DNA polymerase activity' of 'Pol eta:lesioned DNA template inserted with correct base complement'.

Evidence1229
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10856253
xref: http://identifiers.org/pubmed/10369688
comment: Pol eta consists of 713 amino acids and can bypass thymidine-thymidine dimers adding two AÃ¢â¬â¢s correctly opposite to the lesion. Mutations in Pol eta gene result in the loss of this bypass activity in accounting for the XP variant phenotype (XPV) among human xeroderma pigmentosum disorder patients. Pol eta can carry out TLS past various UV and chemical induced lesions via two steps: a. preferential incorporation of correct bases opposite to the lesion b. conditional elongation only at the sites where such correct bases are inserted.

http://identifiers.org/pubmed/7000367
type: PublicationXref
id: 7000367
author: Kozak, M
db: Pubmed
title: Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes.
source: Cell 22:7-8
year: 1981

http://identifiers.org/pubmed/2332429
type: PublicationXref
id: 2332429
author: Vance, JE
db: Pubmed
title: Phospholipid synthesis in a membrane fraction associated with mitochondria
source: J Biol Chem 265:7248-56
year: 1990

UnificationXref8290
type: UnificationXref
id: REACT_144126
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144126.5

UnificationXref8292
type: UnificationXref
id: REACT_142768
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142768.5

UnificationXref8291
type: UnificationXref
id: 3671404
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671404

Synthesis of CL
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction316
evidence: Evidence512
xref: RelationshipXref417
xref: UnificationXref4260
xref: UnificationXref4259
pathway order: PathwayStep509
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8294
type: UnificationXref
id: REACT_95360
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95360.9

UnificationXref8293
type: UnificationXref
id: 3673209
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673209

UnificationXref8296
type: UnificationXref
id: REACT_23184
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23184.2

UnificationXref8295
type: UnificationXref
id: 727753
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727753

http://identifiers.org/pubmed/16682955
type: PublicationXref
id: 16682955
author: Hays, S
author: Westbrook, L
author: Qu, Z
author: Kern, FG
author: Thottassery, JV
author: Rentz, SS
author: Manuvakhova, M
db: Pubmed
title: Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells
source: Oncogene 25:6003-14
year: 2006

UnificationXref8298
type: UnificationXref
id: 3671396
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671396

UnificationXref8297
type: UnificationXref
id: P38318
db: UniProt

Evidence1211
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10583946
comment: At the beginning of this reaction, 1 molecule of 'hNTH1 glycosylase:cytosine glycol complex' is present. At the end of this reaction, 1 molecule of 'cytosine glycol', and 1 molecule of 'DNA containing a hNTH1-bound apurinic/apyrimidinic site' are present. This reaction takes place in the 'nucleus' and is mediated by the 'pyrimidine-specific oxidized base lesion DNA N-glycosylase activity' of 'hNTH1'.

UnificationXref8279
type: UnificationXref
id: REACT_23033
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23033.2

Evidence1212
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'hNTH1 glycosylase:dihydrouracil complex' is present. At the end of this reaction, 1 molecule of 'DNA containing a hNTH1-bound apurinic/apyrimidinic site', and 1 molecule of '5,6-Dihydrouracil' are present. This reaction takes place in the 'nucleus' and is mediated by the 'pyrimidine-specific oxidized base lesion DNA N-glycosylase activity' of 'hNTH1'.

UnificationXref8277
type: UnificationXref
id: REACT_23094
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23094.2

Evidence1210
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10583946
comment: At the beginning of this reaction, 1 molecule of 'hNTH1 glycosylase:thymine glycol' is present. At the end of this reaction, 1 molecule of 'Thymine glycol', and 1 molecule of 'DNA containing a hNTH1-bound apurinic/apyrimidinic site' are present. This reaction takes place in the 'nucleus' and is mediated by the 'pyrimidine-specific oxidized base lesion DNA N-glycosylase activity' of 'hNTH1'.

UnificationXref8278
type: UnificationXref
id: 727735
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727735

Evidence1215
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10583946
comment: Depyrimidination of a damaged nucleotide is mediated by a pyrimidine-specific DNA glycosylase. The glycosylase cleaves the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar generating a free base and an apyrimidinic (AP) site.

Evidence1216
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11937636
xref: http://identifiers.org/pubmed/10583946
comment: Base excision repair is initiated by DNA glycosylases that hydrolytically cleave of the base-deoxyribose glycosyl bond of a damaged nucleotide residue releasing the damaged base (Lindahl and Wood, 1999).

Evidence1213
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'hNTH1 glycosylase: foramidopyrimidine complex' is present. At the end of this reaction, 1 molecule of 'formamidopyrimidine', and 1 molecule of 'DNA containing a hNTH1-bound apurinic/apyrimidinic site' are present. This reaction takes place in the 'nucleus' and is mediated by the 'pyrimidine-specific oxidized base lesion DNA N-glycosylase activity' of 'hNTH1'.

Evidence1214
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10583946
comment: Damaged pyrimidines are first cleaved by pyrimide-specific glycosylases (see Lindahl and Wood 1999).

Evidence1219
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9214649
xref: http://identifiers.org/pubmed/10460157
xref: http://identifiers.org/pubmed/10583946
xref: http://identifiers.org/pubmed/10559261
comment: While the single-nucleotide replacement pathway appears to facilitate the repair of most damaged bases, an alternative BER pathway is evoked when the structure of the terminal sugar phosphate is such that it can not be cleaved through the AP lyase activity of DNA polymerase, POL Beta. Under these circumstances, a short stretch of residues containing the abasic site is excised and replaced (Dianov et al., 1999). Following DNA glycosylase mediated cleavage of the damaged base, the endonuclease APE1 is recruited to the site of damage where it cleaves the 5' side of the base-free deoxyribose residue. POL Beta then displaces the DNA glycosylase and synthesizes the first replacement residue. DNA polymerase, POL Delta replaces POL Beta and mediates the synthesis of several additional residues resulting in the displacement of a DNA flap containing the abasic sugar phosphate and 3ââ¬â¢ flanking residues. The flap structure is recognized and cleaved by the flap endonuclease, FEN1 and the replacement residues are then ligated by the DNA ligase, LIG1 (Klungland and Lindahl, 1997; Matsumoto et al., 1999).

Evidence1217
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'PCNA', and 1 molecule of 'Flap endonuclease-1 ' are present. At the end of this reaction, 1 molecule of 'FEN1:PCNA complex' is present. This reaction takes place in the 'nucleus'.

Evidence1218
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: During removal of DNA patch containing abasic residue, DNA glycosylase is displaced by APE1 which endonucleolytically cleaves the 5' side of the base-free deoxyribose residue. POL Beta is recruited to the AP site where it mediates incorporation of the first replacement nucleotide. Association of POL delta with the AP site displaces POL Beta. DNA strand displacement synthesis then follows and flap structures are cleaved.

Synthesis of PIPs at the Golgi membrane
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction326
pathway component: BiochemicalReaction327
pathway component: BiochemicalReaction323
pathway component: BiochemicalReaction325
pathway component: BiochemicalReaction328
pathway component: BiochemicalReaction329
pathway component: BiochemicalReaction331
pathway component: BiochemicalReaction324
pathway component: BiochemicalReaction330
evidence: Evidence531
xref: RelationshipXref405
xref: UnificationXref4355
xref: UnificationXref4356
pathway order: PathwayStep526
pathway order: PathwayStep527
pathway order: PathwayStep524
pathway order: PathwayStep525
pathway order: PathwayStep523
pathway order: PathwayStep521
pathway order: PathwayStep522
pathway order: PathwayStep528
pathway order: PathwayStep520
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8283
type: UnificationXref
id: REACT_23315
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23315.2

UnificationXref8282
type: UnificationXref
id: 727751
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727751

UnificationXref8281
type: UnificationXref
id: REACT_22831
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22831.2

UnificationXref8280
type: UnificationXref
id: 727787
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727787

UnificationXref8287
type: UnificationXref
id: REACT_22952
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22952.1

UnificationXref8286
type: UnificationXref
id: 727746
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727746

UnificationXref8285
type: UnificationXref
id: REACT_22517
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22517.1

UnificationXref8284
type: UnificationXref
id: 727782
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727782

Evidence1202
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10583946
comment: At the beginning of this reaction, 1 molecule of 'hOGG1 glycosylase: formamidopyrimidine complex' is present. At the end of this reaction, 1 molecule of 'DNA containing an hOGG1-bound apurinic/apyrimidinic site', and 1 molecule of 'formamidopyrimidine' are present. This reaction takes place in the 'nucleus' and is mediated by the 'purine-specific oxidized base lesion DNA N-glycosylase activity' of 'hOGG1 glycosylase'.

Evidence1203
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10583946
comment: Damaged purines are first cleaved by purine-specific glycosylases (see Lindahl and Wood 1999).

Evidence1204
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Depurination of a damaged nucleotide is mediated by a purine-specific DNA glycosylase. The glycosylase cleaves the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar generating a free base and an apurinic (AP) site.

RNA Polymerase I Promoter Clearance
type: Pathway
data source: Provenance1
pathway component: RNA Polymerase I Transcription Initiation
evidence: Evidence887
xref: UnificationXref6987
xref: UnificationXref6986
xref: RelationshipXref888
pathway order: PathwayStep891
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence1205
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'hNTH1', and 1 molecule of 'Double-strand DNA containing a cytosine glycol' are present. At the end of this reaction, 1 molecule of 'hNTH1 glycosylase:cytosine glycol complex' is present. This reaction takes place in the 'nucleus'.

UnificationXref8266
type: UnificationXref
id: 3668318
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668318

UnificationXref8267
type: UnificationXref
id: REACT_107470
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107470.9

Evidence1200
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9724657
comment: The recognition and cleavage of an altered base by a DNA glycosylase is thought to involve the diffusion of the enzyme along the minor grove of the DNA molecule. The enzyme presumably compresses the backbone of the affected DNA strand at the site of damage. This compression is thought to result in an outward rotation of the damaged residue into a "pocket" of the enzyme that recognizes and cleaves the altered base (Parikh et al., 1998).

UnificationXref8268
type: UnificationXref
id: 3668313
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668313

Evidence1201
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10583946
comment: At the beginning of this reaction, 1 molecule of 'hOGG1 glycosylase:8-oxo guanine complex' is present. At the end of this reaction, 1 molecule of '8-oxoguanine', and 1 molecule of 'DNA containing an hOGG1-bound apurinic/apyrimidinic site' are present. This reaction takes place in the 'nucleus' and is mediated by the 'purine-specific oxidized base lesion DNA N-glycosylase activity' of 'hOGG1 glycosylase'.

UnificationXref8269
type: UnificationXref
id: REACT_91308
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91308.9

Evidence1206
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'hNTH1', and 1 molecule of 'Double-strand DNA containing a dihydrouracil' are present. At the end of this reaction, 1 molecule of 'hNTH1 glycosylase:dihydrouracil complex' is present. This reaction takes place in the 'nucleus'.

Evidence1207
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'hNTH1', and 1 molecule of 'Double-strand DNA containing a formamidopyrimidine ' are present. At the end of this reaction, 1 molecule of 'hNTH1 glycosylase: foramidopyrimidine complex' is present. This reaction takes place in the 'nucleus'.

Evidence1208
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'hNTH1', and 1 molecule of 'Double-strand DNA containing a thymine glycol ' are present. At the end of this reaction, 1 molecule of 'hNTH1 glycosylase:thymine glycol' is present. This reaction takes place in the 'nucleus'.

Evidence1209
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11937636
comment: Base excision repair is initiated by a DNA glycosylase which first recognizes and removes a damaged or incorrect (e.g. mismatched) base.

UnificationXref8274
type: UnificationXref
id: 727743
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727743

UnificationXref8273
type: UnificationXref
id: REACT_23113
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23113.2

UnificationXref8276
type: UnificationXref
id: 727739
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727739

UnificationXref8275
type: UnificationXref
id: REACT_22546
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22546.2

UnificationXref8270
type: UnificationXref
id: 727755
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727755

UnificationXref8272
type: UnificationXref
id: 727758
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=727758

UnificationXref8271
type: UnificationXref
id: REACT_22579
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22579.2

UnificationXref8259
type: UnificationXref
id: 83961
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83961

UnificationXref8257
type: UnificationXref
id: 83959
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83959

UnificationXref8258
type: UnificationXref
id: REACT_4570
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4570.2

UnificationXref8255
type: UnificationXref
id: 83957
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83957

UnificationXref8256
type: UnificationXref
id: REACT_3780
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3780.2

http://identifiers.org/pubmed/18395510
type: PublicationXref
id: 18395510
author: Bigotti, MG
author: Clarke, AR
db: Pubmed
title: Chaperonins: The hunt for the Group II mechanism
source: Arch Biochem Biophys 474:331-9
year: 2008

early endosome membrane
type: CellularLocationVocabulary
xref: UnificationXref4391

UnificationXref8265
type: UnificationXref
id: REACT_94316
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94316.9

late endosome membrane
type: CellularLocationVocabulary
xref: UnificationXref4414

UnificationXref8264
type: UnificationXref
id: 3668314
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668314

UnificationXref8263
type: UnificationXref
id: 3668311
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668311

http://identifiers.org/pubmed/9501078
type: PublicationXref
id: 9501078
author: Brunner, M
author: Káldi, K
author: Neupert, W
author: Bauer, MF
author: Sirrenberg, C
db: Pubmed
title: Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix-targeted preproteins
source: EMBO J 17:1569-76
year: 1998

UnificationXref8262
type: UnificationXref
id: REACT_8842
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_8842.1

UniProt:P18414
type: ProteinReference
xref: UnificationXref9860
organism: BioSource1

early endosome lumen
type: CellularLocationVocabulary
xref: UnificationXref8113

UnificationXref8261
type: UnificationXref
id: 179747
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179747

late endosome lumen
type: CellularLocationVocabulary
xref: UnificationXref8133

UnificationXref8260
type: UnificationXref
id: REACT_2968
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2968.2

endosome lumen
type: CellularLocationVocabulary
xref: UnificationXref8383

http://identifiers.org/pubmed/8163536
type: PublicationXref
id: 8163536
author: Sidorenko, SP
author: Chandran, KA
author: Clark, EA
author: Disteche, CM
author: Edelhoff, S
author: Law, CL
author: Weiss, A
author: Chan, AC
author: Draves, KE
db: Pubmed
title: Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex
source: J Biol Chem 269:12310-9
year: 1994

Evidence1265
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9111189
comment: The resultant gap is filled by polymerase activities of Pol delta and Pol epsilon. Accessory replication protein complexes of RPA, PCNA and RFC play a role in this synthesis. DNA Ligase 1 seals the gap restoring the covalent integrity of the repaired strand.

Evidence1264
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: DNA Ligase 1 ligates the newly synthesized fragment to the gap in the template DNA.

Evidence1267
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: An active Pol II complex consisting mainly of the Pol II holoenzyme transcribes the damaged DNA template.

Evidence1266
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: GG-NER is considered to be transcription-independent, removing lesions from non-transcribed regions of genome in addition to non-transcribed strands of transcribed regions. The three events that characterize NER are well characterized in GG-NER: damage recognition, bimodal incision of DNA via repair protein complex, resulting excision of DNA fragment with the lesion. Post-excision polymerization and ligation restore back the native chemistry and configuration to the damaged DNA.

Evidence1269
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: A proper assembly of repair complex may require displacement of Pol II from the damage site exposing a significant length of the corresponding template DNA with the lesions. Speculations on the mode of this displacement of Pol II are available from experimental evidences: a. CSB mediated dissociation of Pol II b. degradation of Pol II c. CSB mediated remodeling of damaged DNA-RNA PII interface etc. The TC-repair complex now consists of damaged DNA template: nascent mRNA hybrid. The damage site needs to be exposed to subsequent endonuclease activities.

Evidence1268
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the site of damage, the Pol II complex is arrested resulting in reduced levels of transcription. Several models have been proposed to explain the mechanism of this transcriptional downregulation. These include a. hyperphosphorylation of Pol II resulting in aborted entry to new pre-initiation complexes b. sequestration of TATA-binding proteins (TBP) c. enhanced use of TFIIH complexes for repair purposes precluding their use in transcription.

Evidence1260
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10214908
comment: ERCC1-XPF complex with 5ââ¬â¢ endonuclease activity binds to this pre-incision complex around the bubble structure to form an active incision complex.

Evidence1261
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Binding of XPC complex to the damaged site on the DNA substrate is followed by XPA and RPA recruitment. XPA is a metalloprotein that binds to different types of DNA damage. Binding of RPA, or Replicative protein A, a heterotrimer, initiates the formation of incision complex. This includes a serial assembly of the rest of the NER machinery consisting of TFIIH, XPG etc. Action of helicases in TFIIH complex opens up a bubble structure in the DNA template, exposing a fragment of DNA with lesion for endonuclease activity.

Evidence1262
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10214908
comment: The cleavage of the damaged strand of DNA 3' to the site of damage occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision is carried out by XPG.

Evidence1263
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10583946
comment: Dual incision at defined positions flanking the DNA damage is carried out by XPG (3' -incision) and ERCC1-XPF (5'-incision) complex. The resulting excised fragment is ~27-30 bp long and contains the lesion.

http://identifiers.org/pubmed/8670417
type: PublicationXref
id: 8670417
author: Tarakhovsky, A
author: Guinamard, R
author: Stabel, S
author: Schaal, S
author: Davoust, J
author: Leitges, M
author: Schmedt, C
db: Pubmed
title: Immunodeficiency in protein kinase cbeta-deficient mice
source: Science 273:788-91
year: 1996

Evidence1256
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Disruption of normal Watson-Crick base pairing and altered chemistry in the damaged strand involving bases may act as signals of damage that are recognized by XPC:HR23B complex.

Evidence1255
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: XPC is mutated in individuals with xeroderma pigmentosum from genetic Complementation Group C (XP-C). It forms a tight heterodimeric complex with human Rad 23B homolog, HR23B and is thought to bind to the damaged site with lesion first triggering subsequent reactions

Evidence1254
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12897142
comment: Numerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-strand breaks (DSBs), one of the most dangerous type of DNA damage along with interstrand crosslinks, are caused by ionizing radiation or certain chemicals such as bleomycin, and occur normally during the processes of DNA replication, meiotic exchange, and V(D)J recombination. Two distinct mechanisms for DSB repair are the error-free homologous recombination repair (HRR) pathway and the error-prone nonhomologous end-joining (NHEJ) pathway. The choice of pathway may be determined by whether the DNA region has already replicated and the precise nature of the break. NHEJ functions at all stages of the cell cycle, but plays the predominant role in both the G1 phase and in S-phase regions of DNA that have not yet replicated (Rothkamm et al. 2003). HRR functions primarily in repairing both one-sided DSBs that arise at DNA replication forks and two-sided DSBs arising in S or G2-phase chromatid regions that have replicated.

Evidence1253
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11376695
xref: http://identifiers.org/pubmed/12427531
xref: PublicationXref2389
xref: http://identifiers.org/pubmed/11242102
xref: http://identifiers.org/pubmed/12954758
comment: The HRR pathway is an "error free" DNA repair mechanism that utilizes information encoded by homologous sequence to repair double-strand breaks (DSBs). HRR acts on DSBs occurring within replicated DNA (replication-independent DSBs) or on DSBs that are generated at broken replication forks (replication-dependent DSBs). Repair by homologous recombination involves processing of the ends of the DNA double-strand break, homologous DNA pairing and strand exchange, repair DNA synthesis, and resolution of the heteroduplex molecules.

Evidence1259
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'ERCC1, DNA excision repair protein', and 1 molecule of 'XPF protein' are present. At the end of this reaction, 1 molecule of 'ERCC1:XPF complex' is present. This reaction takes place in the 'nucleus'.

Evidence1258
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Two DNA helicases XPG and XPD, which are part of TFIIH, unwind DNA duplex around this lesion to form an open bubble structure that exposes the damaged site.

Sulfide oxidation to sulfate
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction542
evidence: Evidence812
xref: UnificationXref6280
xref: UnificationXref6281
xref: RelationshipXref811
pathway order: PathwayStep813
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence1257
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Several subunits of the NER multiprotein repair machinery are required for the recognition of damage in DNA. Mainly, XPC, HR23B, XPA and RPA are implicated in this process. XPA and RPA are thought to be binding to the damage site after the binding of XPC-HR23B complex.

Evidence1251
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12902160
comment: Once repair synthesis has occurred, the D-loop structure may be resolved either through Holliday junction intermediates of through synthesis-dependent strand-annealing.

Evidence1252
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Homologous recombination repair of replication-independent double-strand breaks requires the activation of ATM followed by ATM mediated phosphorylation of DNA repair proteins. DNA repair and signaling proteins are then recruited to double-strand breaks. The ends of the DNA double strand breaks must be resectioned and RPA complexes associate with the resulting ssDNA. Homologous DNA pairing and strand exchange then occurs followed by DNA repair synthesis and resolution of D-loop structures.

Evidence1250
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Following the synthesis of new DNA at resected 5' ends of the DSB, the heterologous DNA molecules may be ligated resulting in the formation of Holliday junctions. The Holliday structures are then cleaved resulting in reciprocal exchange of sequence between sister chromatids.

UniProt:P00424 COX5A
type: ProteinReference
name: YNL052W
name: COX5A
name: N2474
name: YNL2474W
xref: UnificationXref820
comment: CATALYTIC ACTIVITY 4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O.SUBUNIT Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.MISCELLANEOUS Present with 3670 molecules/cell in log phase SD medium.SIMILARITY Belongs to the cytochrome c oxidase IV family.
organism: BioSource1

Evidence1247
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2389
comment: The presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from ssDNA, followed by the association of RAD51 with BRCA2, formation of RAD52 heptameric ring structure complexes on ssDNA, association of RAD52 with the RPA complex, association of RAD52 with ssDNA at resected ends of double-strand break and assembly of the RAD51-ssDNA nucleoprotein complex.

Evidence1246
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11751636
xref: http://identifiers.org/pubmed/12606939
xref: http://identifiers.org/pubmed/11080452
xref: http://identifiers.org/pubmed/10921897
xref: http://identifiers.org/pubmed/11459989
comment: The RAD51-ssDNA nucleoprotein filament is a right-hand helical nucleoprotein filament referred to as the presynaptic filament. This nucleoprotein complex contains a binding site for the double-stranded homologous DNA molecule with which it interacts during strand exchange. Loading of RAD51 onto ssDNA is thought to be facilitated by recombination mediator RAD52 (McIlwraith et al., 2000), RAD51 paralogs: RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 (Sigurdsson et al., 2001), by the association of RAD52 with ssDNA (Parsons et al., 2000) and by the association of RAD51 with BRCA2 (Tarsounas et al., 2003).

Evidence1249
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Ligation of the crossed-strand intermediate results in the formation of Holliday structures with two crossovers. In humans, the identity of this ligase activity involved in this process is not known.

Evidence1248
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9880493
xref: http://identifiers.org/pubmed/12912992
xref: http://identifiers.org/pubmed/12205100
comment: The presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from ssDNA, followed by the association of RAD51 with BRCA2, formation of RAD52 heptameric ring structure complexes on ssDNA, association of RAD52 with the RPA complex, association of RAD52 with ssDNA at resected ends of double-strand break and assembly of the RAD51-ssDNA nucleoprotein complex. Stable synaptic pairing between recombining DNA molecules involves the invasion of homologous duplex DNA by the processed single-stranded ends of the double-strand break, followed by displacement of the non-complimentary strand of the duplex. This results in the formation of a D-loop structure. Invasion of the heteroduplex DNA by RAD51 nucleoprotein filament involves the identification of a region of homology between these two molecules. The mechanism by which this occurs is not yet known. RAD51 catalyses the invasion of the nucleoprotein filament into homologous double-stranded DNA. Watson-Crick hydrogen bonding between the ssDNA within the nucleoprotein filament and the homologous strand of the invaded DNA duplex result in the displacement of the non-pairing strand (strand displacement) and formation of the D-loop structure (Sung et al., 2003). The RAD51 nucleoprotein filament has independent binding sites for the ssDNA strand upon which it assembles and the recombining homologous duplex DNA. The repair proteins RPA, RAD52, and RAD54 appear to promote RAD51 mediated invasion and homologous DNA pairing reaction (McIlwraith et al, 2000 and Sigurdsson et al., 2002). The conformation of the RAD52-ssDNA complex is thought to place the ssDNA on an exposed surface of the protein, in a configuration that may promote the DNA-DNA annealing of complementary DNA strands. RAD54 may function in the transient separation of the duplex DNA strands via its ATP hydrolysis-mediated DNA supercoiling function (Sigurdsson et al., 2002). Branch migration or strand exchange occurs as the complime…

Evidence1243
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10921897
comment: At the beginning of this reaction, 1 molecule of '3' overhanging DNA at resected DSB ends', and 1 molecule of 'RAD52' are present. At the end of this reaction, 1 molecule of 'RAD52:DNA double-strand break' is present. This reaction takes place in the 'nucleus'.

Evidence1242
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14695167
xref: http://identifiers.org/pubmed/10959836
xref: http://identifiers.org/pubmed/14532133
xref: http://identifiers.org/pubmed/12949583
comment: Following exposure to ionizing radiation, a number of recombination/repair proteins and complexes relocalize to nuclear foci that are believed to correspond to the sites of double-strand breaks. These proteins include gamma-H2AX, ATM, RAD51, BRCA1, BRCA2, NBS1, RPA, and MDC1/NFBD1 and the MRE11-RAD50-NBS1. Gamma-H2AX, the phosphorylated form of H2AX, is one of the first proteins to appear within nuclear foci and plays an essential role in recruiting other repair proteins (Paull et al., 2000). One model illustrating the organization of the recruited repair proteins (Van den Bosch et al., 2003) is shown here. (A) Undamaged section of a chromosome, showing two chromatin loops and an inactive ATM dimer. (B,C) Induction of a DNA double-stranded break (DSB), modification of chromatin, activation of ATM and recruitment of both ATM and MRE11/RAD50/NBS1(MRN). The possibility that MRN binds before ATM is shown, but the activation of ATM appears to require the MDC1 and the MRN complex (Uziel, et al 2003; Mochan et al. 2003). The thin black line indicates modified chromatin. (D,E) Following DNA damage, a wave of H2AX phosphorylation occurs and the mediator proteins (mediator of DNA damage checkpoint protein 1 (MDC1), p53-binding protein 1(53BP1), and breast-cancer-associated protein 1(BRCA1)) are recruited to the growing focus where they are phosphorylated in an ATM-dependent manner. The molecular architecture of the focus is unknown. (F) Disassembly of the focus, ATM inactivation and chromatin remodeling. The model suggests at least two distinct forms of soluble ATM: an inactive oligomer and an active monomer, and at least two distinct active, insoluble forms: one directly at the lesion and another integral to the growing focus. Note that the MRN complex is also a component of the growing focus, but for clarity, has been omitted here. Complex persistent lesions are thought to be more difficult to repair, and this is reflected in the size attained by the growing focus.

Evidence1245
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11080452
comment: At the beginning of this reaction, 1 molecule of 'RAD51', and 1 molecule of '3' overhanging DNA at resected DSB ends' are present. At the end of this reaction, 1 molecule of 'RAD51:resected ends of DNA double-strand break' is present. This reaction takes place in the 'nucleus'.

Evidence1244
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10438626
comment: Binding of the RAD51:RAD52 complex to ssDNA may provide nucleation sites promoting the association of free RAD51 with the growing nucleoprotein filament. This interaction may also play a role in stimulating the strand transfer reactions mediated by RAD51 (Baumann, 1999).

Evidence1240
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks involves the formation of RAD50:MRE11 complex, association of RAD50:MRE11 complex with NBS1 through MRE11 and association of the MRN with sites of DSB.

Evidence1241
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9705271
xref: http://identifiers.org/pubmed/9554850
xref: http://identifiers.org/pubmed/12152085
comment: MRN complexes localize to nuclear foci in response to double-strand breaks and have been implicated in DNA end-processing during homologous recombination repair (Trujillo et al., 1998). The MRN complex may function as a bridge between double-strand break ends through interactions between the coiled-coil domains of RAD50 (Hoptner et al., 2002).

half cystine
type: SequenceModificationVocabulary
xref: UnificationXref668

http://identifiers.org/pubmed/7559569
type: PublicationXref
id: 7559569
author: Buhl, AM
author: Dhanasekaran, N
author: Johnson, NL
author: Johnson, GL
db: Pubmed
title: G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly
source: J Biol Chem 270:24631-4
year: 1995

Evidence1239
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: MRE11 has both manganese dependent ss DNA 3'-5' exonuclease and endonuclease activities. MRE11 associates with RAD50 resulting in increased 3'-5' exonuclease activity.

Evidence1238
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12034743
comment: Detection of DNA double-strand breaks involves sensor proteins that become activated setting off of signaling cascades. This signaling leads to the recruitment of repair proteins and subsequent repair of the damaged DNA. ATM is one of the primary candidate sensors in double-strand break repair.

Evidence1237
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12427531
comment: Following the detection of DSBs, ATM mediates the phosphorylation of proteins involved in DNA repair (Thompson and Schild, 2002).

Evidence1236
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12607005
xref: http://identifiers.org/pubmed/10959836
xref: http://identifiers.org/pubmed/9488723
comment: H2AX phosphorylation (producing the gamma-H2AX protein form) occurs within 1-3 minutes of DNA damage (Rogakou et al,1998) and is promoted by MDC1/NFBD1 (Stewart et al., 2003). gamma H2AX is one of the first proteins to appear at the site of damage, localizing to a region of about 2 Mbp surrounding the site of the double-strand break (Rogakou et al,1998). gamma-H2AX appears to play an essential role in recruiting other repair proteins including Rad50, Rad51 and BRCA1(Paull et al., 2000) (Stewart et al., 2003).

Evidence1235
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12556884
comment: Autophosphorylation of ATM results in the dissociation of the dimeric/multimeric ATM complex and initiation of ATM kinase activity. Autophosphorylation does not directly regulate ATM kinase activity. Instead, it is the resulting dissociation of ATM oligomers that allows substrates access to the ATM kinase domain.

Evidence1234
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12556884
comment: ATM is present in unirradiated cells as a dimer or higher-order multimer. Following irradiation, ATM undergoes rapid intermolecular autophosphorylation of serine 1981.

Evidence1233
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: DNA damage can be directly reversed by dealkylation.

Synthesis of PG
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction313
pathway component: BiochemicalReaction312
evidence: Evidence507
xref: RelationshipXref411
xref: UnificationXref4235
xref: UnificationXref4234
pathway order: PathwayStep504
pathway order: PathwayStep503
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence1232
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8434121
comment: Reactive cellular catabolites can cause DNA damage by 6-O-methylation of guanine. 6-O-methylguanine can pair ambiguously with both C and T, and can cause transition mutations. Active reversal of such damage can be facilitated by proteins having 6-O-methylguanine-DNA methyltransferase (MGMT) activity. MGMT removes the methyl group from the guanine and transfers it to the cysteine residue at position 145 on the protein itself. MGMT thus methylated is not regenerated, as the S-methylcysteine is very stable. This is an energetically expensive approach to DNA repair as one entire protein molecule is sacrificed per lesion that is corrected in this manner (Yang et al. 2011).

Evidence1231
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11595180
xref: http://identifiers.org/pubmed/10925197
xref: http://identifiers.org/pubmed/12800216
comment: In addition to various processes for removing damaging lesions from the DNA, cells have developed specific mechanisms for tolerating unexcised damages during the replication of the genome. Such processes are collectively called DNA damage bypass pathways. Several proteins including novel Y-family polymerases that have been recently identified in multitude of organisms are involved in this process. Translesion synthesis (TLS) or replicative bypass of damaged bases that are known to arrest high fidelity, highly processive polymerases involved in DNA replication is carried out by error-prone polymerases Pol zeta, Pol eta and Rev3 protein among others. TLS is implicated in UV and chemical induced mutagenesis of normal human cells where lesions in the replicating genome are carried over to the newly formed daughter cells. All these 3 enzymes are found to lack 3ââ¬â¢->5ââ¬â¢ exonuclease activity, while exhibiting low fidelity, weak processivity and sufficient polymerase activities. An outline of the bypass synthesis by these 3 enzymes is annotated here. Complete details of damage recognition and discrimination, initiation of specific polymerase activity and the finer mechanisms are yet to be elucidated.

UnificationXref8299
type: UnificationXref
id: P38317
db: UniProt

Evidence1230
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10856253
xref: http://identifiers.org/pubmed/10583946
comment: Ubiquitous environmental and endogenous genotoxic agents cause lesions that can interfere with normal DNA metabolism including DNA replication, eventually resulting in mutations that lead to carcinogenesis and/or cell death. While cells posses repair mechanisms like nucleotide excision and base excision repair pathways to maintain the integrity of the genome, not all lesions on the genome can be repaired efficiently by these processes in time for DNA replication, and some types of lesion are repaired very inefficiently. To prevent acute cell death through arrested DNA replication at unrepaired lesions, cells have a mechanism, referred to as translesion synthesis, which allows DNA synthesis to proceed past lesions (Masutani et al., 2000).

Evidence1294
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17052215
xref: http://identifiers.org/pubmed/19909372
comment: Second messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RAS via RasGRP proteins, NF-AT via calcineurin, and AKT via PDK1 (reviewed in Shinohara and Kurosaki 2009, Stone 2006).

Evidence1293
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7957109
xref: http://identifiers.org/pubmed/3129195
xref: http://identifiers.org/pubmed/7575604
xref: http://identifiers.org/pubmed/16301747
xref: http://identifiers.org/pubmed/9721103
xref: http://identifiers.org/pubmed/7628694
xref: http://identifiers.org/pubmed/19066035
xref: http://identifiers.org/pubmed/8387275
xref: http://identifiers.org/pubmed/7809113
xref: http://identifiers.org/pubmed/18462924
xref: http://identifiers.org/pubmed/16356855
xref: http://identifiers.org/pubmed/7862124
xref: http://identifiers.org/pubmed/7479848
xref: http://identifiers.org/pubmed/11460167
xref: http://identifiers.org/pubmed/9914500
xref: http://identifiers.org/pubmed/7479976
xref: http://identifiers.org/pubmed/17428801
xref: http://identifiers.org/pubmed/10593898
xref: http://identifiers.org/pubmed/7831327
xref: http://identifiers.org/pubmed/1756723
comment: DAG and calcium activate protein kinase C beta (PKC-beta, Kochs et al. 1991) which phosphorylates CARMA1 and other proteins (Sommer et al. 2005). Phosphorylated CARMA1 recruits BCL10 and MALT1 to form the CBM complex (Sommer et al. 2005, Tanner et al. 2007) which, in turn, recruits the kinase TAK1 and the IKK complex (Sommer et al. 2005, Shinohara et al. 2005 using chicken cells). TAK1 phosphorylates the IKK-beta subunit, activating it (Wang et al. 2001). The IKK complex then phosphorylates IkB complexed with NF-kappaB dimers in the cytosol (Zandi et al. 1998, Burke et al. 1999, Heilker et al. 1999), resulting in the degradation of IkB (Miyamoto et al. 1994, Traenckner et al. 1994, Alkalay et al. 1995, DiDonato et al. 1995, Li et al. 1995, Lin et al. 1995, Scherer et al. 1995, Chen et al. 1995). NF-kappaB dimers are thereby released and are translocated to the nucleus where they activate transcription (Baeuerle and Baltimore 1988, Blank et al. 1991, Ghosh et al. 2008, Fagerlund et al. 2008).

Evidence1296
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16954532
xref: http://identifiers.org/pubmed/12646216
xref: http://identifiers.org/pubmed/19874575
xref: http://identifiers.org/pubmed/19489725
comment: Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).

Evidence1295
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18596693
xref: http://identifiers.org/pubmed/19249086
xref: http://identifiers.org/pubmed/4589993
xref: http://identifiers.org/pubmed/19065780
xref: http://identifiers.org/pubmed/15489917
xref: http://identifiers.org/pubmed/7538118
xref: http://identifiers.org/pubmed/1375264
xref: http://identifiers.org/pubmed/18818202
xref: http://identifiers.org/pubmed/10648173
xref: http://identifiers.org/pubmed/8580068
xref: http://identifiers.org/pubmed/18187424
xref: http://identifiers.org/pubmed/7688784
xref: http://identifiers.org/pubmed/2011584
xref: http://identifiers.org/pubmed/8306975
xref: http://identifiers.org/pubmed/8163536
xref: http://identifiers.org/pubmed/15509800
xref: http://identifiers.org/pubmed/11901194
xref: http://identifiers.org/pubmed/7524079
xref: http://identifiers.org/pubmed/1081164
xref: http://identifiers.org/pubmed/7927516
xref: http://identifiers.org/pubmed/1702903
xref: http://identifiers.org/pubmed/1376928
xref: http://identifiers.org/pubmed/17052215
xref: http://identifiers.org/pubmed/6335036
xref: http://identifiers.org/pubmed/19909372
xref: http://identifiers.org/pubmed/16849466
xref: http://identifiers.org/pubmed/7592958
xref: http://identifiers.org/pubmed/20206686
xref: http://identifiers.org/pubmed/803528
xref: http://identifiers.org/pubmed/20192804
comment: Mature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, Fu et al. 1975, Kunkel et al. 1975, Van Noesel et al. 1992, Sanchez et al. 1993, reviewed in Brezski and Monroe 2008). Binding of antigen to the immunoglobulin activates phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the cytoplasmic tails of Ig-alpha and Ig-beta by Src family tyrosine kinases, including LYN, FYN, and BLK (Nel et al. 1984, Yamanashi et al. 1991, Flaswinkel and Reth 1994, Saouaf et al. 1994, Hata et al. 1994, Saouaf et al. 1995, reviewed in Gauld and Cambier 2004, reviewed in Harwood and Batista 2010). The protein kinase SYK binds the phosphorylated immunoreceptor tyrosine-activated motifs (ITAMs) on the cytoplasmic tails of Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) (Wienands et al. 1995, Rowley et al. 1995, Tsang et al. 2008). The binding causes the activation and autophosphorylation of SYK (Law et al. 1994, Baldock et al. 2000, Irish et al. 2006, Tsang et al. 2008, reviewed in Bradshaw 2010). Activated SYK and other kinases phosphorylate BLNK (SLP-65), BCAP, and CD19 which serve as scaffolds for the assembly of large complexes, the signalosomes, by recruiting phosphoinositol 3-kinase (PI3K), phospholipase C gamma (predominantly PLC-gamma2 in B cells, Coggeshall et al. 1992), NCK, BAM32, BTK, VAV1, and SHC. The effectors are phosphorylated by SYK and other kinases. PLC-gamma associated with BLNK hydrolyzes phosphatidylinositol-4,5-bisphosphate to yield inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (Carter et al. 1991, Kim et al. 2004). IP3 binds receptors on the endoplasmic reticulum and causes release of calcium ions from the ER into the cytosol. The depletion of calcium from the ER in turn activates STIM1 to interact with ORAI and TRPC1 channels in the plasma membrane, resulting in an influx of extracellular c…

Evidence1290
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12165654
xref: http://identifiers.org/pubmed/8609386
xref: http://identifiers.org/pubmed/8649453
comment: In naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation of an antiapoptotic program. CD28 engages with one or both members of the B7 receptor family, B7.1 and B7.2. Upon ligand binding the tyrosines and proline-rich motifs present in the cytoplasmic tail of CD28 are phosphorylated by Lck or Fyn. Upon phosphorylation CD28 recruits and induces phosphorylation and activation of a more restricted set of intracellular signaling components that, together with those mobilized by the TCR, contribute to convert membrane-based biochemical and biophysical changes into gene activation events. Proteins like PI3K, Vav-1, Tec and Itk kinases, AKT, and the Dok-1 adaptor have been identified as elements of the CD28 signaling pathway by biochemical or genetic approaches or both.

Evidence1292
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12070292
xref: http://identifiers.org/pubmed/8670417
xref: http://identifiers.org/pubmed/12118249
xref: http://identifiers.org/pubmed/8387275
comment: Human Protein kinase C beta (PKC-beta) is activated by calcium ions, diacylglycerol, and binds phosphatidylserine (Kochs et al. 1991). Experiments in mice have shown that knocking out PKC-beta causes severe defects in B cells, leading to the conclusion that PKC-beta is the predominant signaling PKC in these cells (Leitges et al. 1996, Su et al. 2002, Saijo et al. 2002).

Evidence1291
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11905831
xref: http://identifiers.org/pubmed/10374692
xref: http://identifiers.org/pubmed/14647476
comment: Optimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are delivered by the engagement of costimulatory receptors such as CD28. The best-characterized costimulatory pathways are mediated by a set of cosignaling molecules belonging to the CD28 superfamily, including CD28, CTLA4, ICOS, PD1 and BTLA receptors. These proteins deliver both positive and negative second signals to T-cells by interacting with B7 family ligands expressed on antigen presenting cells. Different subsets of T-cells have very different requirements for costimulation. CD28 family mediated costimulation is not required for all T-cell responses in vivo, and alternative costimulatory pathways also exist. Different receptors of the CD28 family and their ligands have different regulation of expression. CD28 is constitutively expressed on naive T cells whereas CTLA4 expression is dependent on CD28/B7 engagement and the other receptor members ICOS, PD1 and BTLA are induced after initial T-cell stimulation. The positive signals induced by CD28 and ICOS molecules are counterbalanced by other members of the CD28 family, including cytotoxic T-lymphocyte associated antigen (CTLA)4, programmed cell death (PD)1, and B and T lymphocyte attenuator (BTLA), which dampen immune responses. The balance of stimulatory and inhibitory signals is crucial to maximize protective immune responses while maintaining immunological tolerance and preventing autoimmunity. The costimulatory receptors CD28, CTLA4, ICOS and PD1 are composed of single extracellular IgV-like domains, whereas BTLA has one IgC-like domain. Receptors CTLA4, CD28 and ICOS are covalent homodimers, due to an interchain disulphide linkage. The costimulatory ligands B71, B72, B7H2, B7H1 and B7DC, have a membrane proximal IgC-like domain and a membrane distal IgV-like domain that is responsible for receptor binding and dimer…

UniProt:Q00955
type: ProteinReference
xref: UnificationXref3312
organism: BioSource1

Evidence1297
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15571818
xref: http://identifiers.org/pubmed/14734113
xref: http://identifiers.org/pubmed/9380723
xref: http://identifiers.org/pubmed/11350924
xref: http://identifiers.org/pubmed/15224092
xref: http://identifiers.org/pubmed/15224091
comment: The 26S proteasome complex consists of the 20S catalytic core particle which harbours the proteolytically active sites and the regulatory 19S particle which is responsible for substrate interaction. This process generates a vast number (perhaps hundreds) of different peptides, depending on the length and sequence of the substrate protein. Only a small fraction of these peptides (nearly 10%) form the exact length to be presented by class I MHC; most (approximately 70%) are too short to bind. The remaining proteasome products (10-20%) are N-terminally extended precursors that require additional cleavage by cytosolic aminopeptidases for presentation by MHC class I molecules.

Evidence1298
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16849449
xref: http://identifiers.org/pubmed/11062501
xref: http://identifiers.org/pubmed/9668046
xref: http://identifiers.org/pubmed/15224092
xref: http://identifiers.org/pubmed/15224091
comment: Some peptides generated by the 26S proteasome are too long to bind to MHC class I molecules. These N-terminal extended precursor peptides may be trimmed by cytosolic aminopeptidases, such as Tripeptidyl peptidase II (TPP2), puromycin-sensitive aminopeptidase (PSA), bleomycin hydrolase (BH), and leucine aminopeptidase (LAP).

Evidence1299
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11917093
xref: http://identifiers.org/pubmed/14734113
xref: http://identifiers.org/pubmed/19489725
xref: http://identifiers.org/pubmed/17145306
xref: http://identifiers.org/pubmed/12648452
xref: http://identifiers.org/pubmed/20351195
comment: Intracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T cells. The ubiquitin-26S proteasome system plays a central role in the generation of these class I MHC antigens. Ubiquitination is the mechanism of adding ubiquitin to lysine residues on substrate protein leading to the formation of a polyubiquitinated substrate. This process involves three classes of enzyme, an E1 ubiquitin-activating enzyme, an E2 ubiquitin-conjugating enzyme, and an E3 ubiquitin ligase. Polyubiquitination through lysine-48 (K48) generally targets the substrate protein for proteasomal destruction. The protease responsible for the degradation of K48-polyubiquitinated proteins is the 26S proteasome. This proteasome is a two subunit protein complex composed of the 20S (catalytic core) and 19S (regulatory) proteasome complexes. The proteasome eliminates most of the foreign and non-functional proteins from the cell by degrading them into short peptides; only a small fraction of the peptides generated are of the correct length to be presented by the MHC class I system. It has been calculated that between 994 and 3122 protein molecules have to be degraded for the formation of a single, stable MHC class I complex at the cell surface, with an average effciency of 1 in 2000 (Kloetzel et al. 2004, Princiotta et al. 2003).

http://identifiers.org/pubmed/17555535
type: PublicationXref
id: 17555535
author: Sherwood, MW
author: Burgoyne, RD
author: Dolman, NJ
author: Haynes, LP
db: Pubmed
title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta
source: Traffic 8:1080-92
year: 2007

UnificationXref8210
type: UnificationXref
id: REACT_147241
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147241.5

UnificationXref8206
type: UnificationXref
id: REACT_20939
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20939.2

UnificationXref8207
type: UnificationXref
id: P38865
db: UniProt

UnificationXref8204
type: UnificationXref
id: REACT_21200
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21200.2

UnificationXref8205
type: UnificationXref
id: 209799
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=209799

http://identifiers.org/pubmed/18706423
type: PublicationXref
id: 18706423
author: Sawaya, MR
author: Schmid, E
author: Beverly, KN
author: Koehler, CM
db: Pubmed
title: The Tim8-Tim13 complex has multiple substrate binding sites and binds cooperatively to Tim23
source: J Mol Biol 382:1144-56
year: 2008

UnificationXref8202
type: UnificationXref
id: CHEBI:29036
db: ChEBI

UnificationXref8203
type: UnificationXref
id: 437295
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=437295

UnificationXref8200
type: UnificationXref
id: 3673512
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673512

UnificationXref8201
type: UnificationXref
id: REACT_135276
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135276.5

UnificationXref8208
type: UnificationXref
id: 3670950
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670950

UnificationXref8209
type: UnificationXref
id: 3670952
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670952

Evidence1270
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: The ââ¬Åroad blockââ¬Â induced by the DNA damage to the transcription machinery triggers assembly of a transcription couple repair complex, whose composition and function are yet to fully understood. Damage recognition is achieved by the arrest of Pol II active complex. Subsequently various factors like CSA, CSB, TFIIH, XPG, XPF-ERCC1 complexes are recruited. The importance of active CSA and CSB are known from the mutation profile of the patients bearing the corresponding disease phenotypes. CSB can act as a ââ¬Ërepair-transcription uncoupling factorââ¬â¢ that may use its DNA translocase activity to remove the Pol II activity from the lesion site. TFIIS may cleave up to 35 nucleotides from the 3ââ¬â¢ end of the nascent RNA product leading to the enhanced access to damage site on the corresponding template DNA.

UniProt:P34110
type: ProteinReference
xref: UnificationXref8735
organism: BioSource1

Evidence1272
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11313499
comment: At the beginning of this reaction, 1 molecule of 'Transcription-coupled (TC) repair complex', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid' are present. At the end of this reaction, 1 molecule of 'Transcription-coupled (TC) repair complex', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid with 3' incision' are present. This reaction takes place in the 'nucleus' and is mediated by the 'endodeoxyribonuclease activity' of 'Transcription-coupled (TC) repair complex'.

YAL001C
type: ProteinReference
name: UniProt:P34111 TFC3
name: TFC3
name: FUN24
name: TSV115
xref: UnificationXref6998
comment: FUNCTION TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. TFC3 is essential for cell viability. Cooperates with TFC6 in DNA binding.SUBUNIT Component of the TFIIIC complex composed of TFC1, TFC3, TFC4, TFC6, TFC7 and TFC8. The subunits are organized in two globular domains, tauA and tauB, connected by a proteolysis-sensitive and flexible linker. Interacts with TFC1, TFC4 and TFC6.MISCELLANEOUS Present with 125 molecules/cell in log phase SD medium.
organism: BioSource1

Evidence1271
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'Transcription-coupled (TC) repair complex', and 1 molecule of 'Stalled Pol II complex with damaged DNA hybrid' are present. At the end of this reaction, 1 molecule of 'Transcription-coupled (TC) repair complex', 1 molecule of 'Stalled Pol II in TC-NER', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid' are present. This reaction takes place in the 'nucleus'.

Evidence1274
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Dual incisions are carried out by XPG, and ERCC1-XPF complex as seen in GG-NER.

Evidence1273
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11313499
comment: At the beginning of this reaction, 1 molecule of 'Transcription-coupled (TC) repair complex', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid with 3' incision' are present. At the end of this reaction, 1 molecule of 'Transcription-coupled (TC) repair complex', 1 molecule of 'excised DNA fragment with lesion', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid with dual incisions' are present. This reaction takes place in the 'nucleus' and is mediated by the 'endodeoxyribonuclease activity' of 'Transcription-coupled (TC) repair complex'.

Evidence1275
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'newly synthesized DNA fragment ', 1 molecule of 'DNA ligase I ', and 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid with dual incisions' are present. At the end of this reaction, 1 molecule of 'repaired DNA template:nascent mRNA hybrid', and 1 molecule of 'DNA ligase I ' are present. This reaction takes place in the 'nucleus' and is mediated by the 'DNA ligase activity' of 'DNA ligase I '.

Evidence1276
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Polymerization is carried out by DNA polymerases, delta and epsilon.

Evidence1277
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the beginning of this reaction, 1 molecule of 'Stalled Pol II in TC-NER', and 1 molecule of 'repaired DNA template:nascent mRNA hybrid' are present. At the end of this reaction, 1 molecule of 'Active Pol II complex with repaired DNA template:mRNA hybrid' is present. This reaction takes place in the 'nucleus'.

Evidence1278
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3466163
xref: http://identifiers.org/pubmed/11823795
comment: The preferential repair of UV-induced damage in transcribed strands of active genes is known as Transcription-coupled NER (TC-NER). Impairment of the ability for TC-NER results in the onset of a severe hereditary disorder called Cockayneââ¬â¢s syndrome, an autosomal recessive disease characterized by hypersensitivity to UV light . Many types of helix distorting lesions can block the movement of elongating RNA Pol II leading to its stalling and subsequent triggering of repair mechanisms. The repair of DNA damage in active genes occurs much faster compared to the repair in non-transcribed genomic regions (via GG-NER). Also, the non-transcribed strand of the same gene is repaired at a similar rate as that of non-transcribed genomic regions. The transcriptional responses to DNA damage in terms of stalling of Pol II, its displacement from the lesion site etc. are not well elucidated. The following annotation in GK provides an overall picture of TC-NER and will be updated as and when new insights are obtained about these crucial steps.

Evidence1279
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11900249
xref: http://identifiers.org/pubmed/14599765
xref: http://identifiers.org/pubmed/10583946
comment: NER was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recovery of DNA synthesis and cell survival. Deficient NER processes have been identified from the cells of cancer-prone patients with different variants of xeroderma pigmentosum (XP), trichothiodystrophy (TTD), and Cockayneââ¬â¢s syndrome. These XP cells exhibited an ultraviolet radiation hypersensitivity leading to a hypermutability response to UV, offering a direct connection between deficient NER, increased mutations, and cancer. While the NER pathway in prokaryotes is unique, the pathway utilized in yeast and higher eukaryotes is highly conserved and includes a variety of proteins that interact to form complexes. NER is involved in the repair of bulky adducts in DNA, such as UV-induced photo lesions [of both 6-4 photoproducts (6-4 pps) and cyclobutane pyrimidine dimer (CPDs)], intrastrand cross-links, large chemical adducts formed from exposure to aflatoxin, benzopyrene and other genotoxic agents. Specific proteins have been identified that participate in base damage recognition, cleavage of the damaged strand on both sides of the lesion, excision of the oligonucleotide bearing the lesion, and accessory proteins necessary for efficient function. Polymerization and ligation restore the strand to its original state. NER consists of two related pathways called global genomic repair (GG-NER) and transcription-coupled NER (TC-NER). The pathways differ in the way in which DNA damage is initially recognized, but the majority of the participating molecules are shared between these two branches of NER". GG-NER is considered to be transcription-independent, removing lesions from non-transcribed regions of genome in addition to non-transcribed strands of transcribed regions. The preferential repair of UV-induced damage in transcribed strands of active genes is known as Transcription-coupled NER (TC-NER). Sever…

UniProt:Q07530
type: ProteinReference
xref: UnificationXref2243
organism: BioSource1

Evidence1281
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10698680
comment: PI3K activation results in recruitment of the serine/threonine kinase PDK1, (3-phosphoinositide-dependent kinase 1) to the plasma membrane where PDK1 subsequently phosphorylates and activates AKT. PDK1 with its PH domain binds to either PIP3 or PIP2 and is translocated to the plasma membrane. PDK1 seems to exist in an active, phosphorylated configuration under basal conditions (Vanhaesebroeck & Alessi 2000).

Evidence1280
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: DNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. These cellular mechanisms that must cope with the plethora of DNA base pair adducts that arise. DNA damage can arise spontaneously in the cellular milieu through chemical alteration of base nucleotides or as a consequence of errors during DNA replication. For example, it is well known that normal cellular pH and temperature offer an environment, which is hostile to the integrity of DNA and its nucleotide components. Additionally, DNA damage may be induced in response to environmental exposures, including exposure to physical agents such as ionizing or ultraviolet (UV) radiation. Finally, specific chemical agents are known to alkylate or cross-link DNA bases, produce bulky adducts on DNA bases, or break DNA phosphate-sugar backbone. The pioneering work from a number of laboratories have elucidated the basic mechanisms underlying distinct DNA repair pathways that include nucleotide excision repair (NER), base excision repair (BER), DNA strand break repair (DSBR), direct reversal of DNA damage, and the replication past DNA lesions by specialized DNA bypass polymerases (bypass replication). Defects in most of these repair pathways have been associated with one or more specific human diseases. Additionally, the repair of damaged DNA is intimately associated with a number of other distinct cellular processes such as DNA replication, DNA recombination, cell cycle checkpoint arrest, and other basic cellular mechanisms as outlined herein.

Evidence1285
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15084594
comment: Changes in gene expression are required for the T cell to gain full proliferative competence and to produce effector cytokines. Three transcription factors in particular have been found to play a key role in TCR-stimulated changes in gene expression, namely NF-kB, NFAT and AP-1. A key step in NF-kB activation is the stimulation and translocation of PKC theta. The critical element that effects PKC theta activation is PI3K. This enzyme complex translocates to the plasma membrane by interacting with phospho-tyrosines on CD28 via its two SH2 domains located in p85 subunit. The p110 subunit of PI3K phosphorylates the inositol ring of PIP2 to generate PIP3 (steps 17-18). PIP3 may also be dephosphorylated by the phosphatase SHIP to generate PI-3,4-P2. PIP3 and PI-3,4-P2 acts as binding sites to the PH domain of PKB/Akt and PDK1 (steps 19, 21 and 22). PKB is activated in response to PI3K stimulation by PDK1 (step 23). PDK1 has an essential role in regulating the activation of PKC theta and recruitment of CBM complex to the immune synapse. PKC theta is a member of novel class (DAG dependent, Ca++ independent) of PKC and the only member known to translocate to this synapse. Prior to TCR stimulation PKC theta exists in an inactive closed conformation. Upon release of DAG, it binds to PKC theta via the C1 domain and undergoes phosphorylation on tyrosine 90 by Lck to attain an open conformation. PKC theta is further phosphorylated by PDK1 on threonine 538. This step is critical for PKC activity (steps 24-26). CARMA1 translocates to the plasma membrane following the interaction of its SH3 domain with the 'PxxP' motif on PDK1. CARMA1 is phosphorylated by PKC-theta on residue S552, leading to the oligomerization of CARMA1. This complex acts as a scaffold, recruiting Bcl10 to the synapse by interacting with their CARD domains. Bcl10 undergoes phosphorylation mediated by the enzyme RIP2. Activated Bcl10 then mediates the ubiquitination of NEMO by recruiting MALT1 and TRAF6. MALT1 bin…

Evidence1284
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12473184
xref: http://identifiers.org/pubmed/16978534
comment: Raft localized PKC theta is further phosphorylated and activated by PDK1. The threonine residue (T538) in the kinase domain is the potential target of PDK1. Phosphorylation of this site is critical for the PKC theta kinase activity, and its ability to activate NF-kB pathway. PKC theta is later trans-autophopshorylated on putative phosphorylation sites (S676, S695) for the fine-tuning of its kinase activity.

Evidence1283
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11358993
xref: http://identifiers.org/pubmed/22798961
xref: http://identifiers.org/pubmed/17548359
xref: http://identifiers.org/pubmed/12024011
comment: DAG along with intracellular calcium signals cooperatively to activate PKCs, which then trigger other pathways such as the NF-kB pathway, ultimately leading to mast cell degranulation and cytokine production (Wu 2011). MCs express several Protein kinase C (PKC) isozymes and these kinases are involved in both the activation and termination of the degranulation process. PKC-delta is a negative regulator of FCERI mediated mast cell degranulation, whereas PKC-theta facilitates in degranulation (Leitges et al. 2002, Liu et al. 2001). In response to FCERI activation PKC-theta translocates to membrane by binding to DAG with its C1 domain. PKC-theta exists in two conformations closed/inactive and open/active state. In resting state, PKC-theta is autoinhibited where the pseudosubstrate sequence in the N-terminal regulatory region of PKC-theta forms intramolecular interaction with the substrate-binding region in the catalytic domain. This prevents the catalytic domain gaining access to substrates. The allosteric change of PKC-theta from closed to open state involves two important mechanisms: DAG binding to the C1 domains and autophosphorylation of T538 on the activation loop. Interaction with DAG induces conformational change resulting in the exposure of the activation loop of PKC-theta (Wang et al. 2012, Melowic et al. 2007).

Evidence1282
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12473184
xref: http://identifiers.org/pubmed/16978534
comment: PKC theta is a member of the Ca++ independent and DAG dependent, novel PKC subfamily expressed mainly in T cells. It contains, N-term C2 like domain, a pseudosubstrate (PS), DAG binding (C1) domain and a C-term kinase domain. The PS sequence resembles an ideal substrate with the exception that it contains an alanine residue instead of a substrate serine residue, is bound to the kinase domain in the resting state. As a result, PKC theta is maintained in a closed inactive state, which is inaccessible to cellular substrates.

Evidence1288
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19513348
xref: http://identifiers.org/pubmed/10470034
comment: In its unbound state PAK is maintained in an inactive conformation through intra domain interactions. On stimulation PAK is translocated to the plasma membrane where it specifically interacts with Rho family GTP-binding proteins Rac1-GTP and Cdc42-GTP. All PAK isoforms are direct effectors of the Rac and Cdc42. Rac and Cdc42 bind to a highly conserved motif in the amino terminus of PAK known as p21-binding domain (PBD) or Cdc42/Rac interactive binding (CRIB) domain. This binding is thought to induce a conformational change in PAK that relieves autoinhibition of the catalytic carboxy terminal domain, thereby inducing autophosphorylation at several sites and enabling the phosphorylation of exogenous substrates.

Evidence1289
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10849438
xref: http://identifiers.org/pubmed/15886116
xref: http://identifiers.org/pubmed/12670394
comment: CD28 binds to several intracellular proteins including PI3 kinase, Grb-2, Gads and ITK. Grb-2 specifically co-operates with Vav-1 in the up-regulation of NFAT/AP-1 transcription. CD28 costimulation resulted in a prolonged and sustained phosphorylation and membrane localization of Vav1 in comparison to T-cell receptor activation alone. Tyrosine-phosphorylated Vav1 is an early point of integration between the signaling routes triggered by the T-cell receptor and CD28. Vav1 transduces TCR and co-stimulatory signals to multiple biochemical pathways and several cytoskeleton-dependent processes. The products of Vav1 activation, Rac1 and Cdc42, in turn activate the mitogen-activated protein kinases JNK and p38. Vav1 is also required for TCR-induced calcium flux, activation of the ERK MAP kinase pathway, activation of the NF-kB transcription factor, inside-out activation of the integrin LFA-1, TCR clustering, and polarisation of the T cell.

Evidence1286
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10375551
xref: http://identifiers.org/pubmed/9989491
xref: http://identifiers.org/pubmed/12876557
comment: The TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen presenting cells (APCs) results in the activation of protein tyrosine kinases (PTKs) that associate with CD3 and TCR zeta subunits and the co-receptor CD4. Members of the Src kinases (Lck), Syk kinases (ZAP-70), Tec (Itk) and Csk families of nonreceptor PTKs play a crucial role in T cell activation. Activation of PTKs following TCR engagement results in the recruitment and tyrosine phosphorylation of enzymes such as phospholipase C gamma1 and Vav as well as critical adaptor proteins such as LAT, SLP-76 and Gads. These proximal activation leads to reorganization of the cytoskeleton as well as transcription activation of multiple genes leading to T lymphocyte proliferation, differentiation and/or effector function.

Evidence1287
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12670391
xref: http://identifiers.org/pubmed/15046602
comment: PI3Ks can be activated by a number of different receptors, including the TcR (T cell receptor), co-stimulatory receptors (CD28), cytokine receptors and chemokine receptors. However, the specific roles of PI3Ks downstream of these receptors vary. CD28 contains the YMNM consensus PI3K-binding motif, and PI3K recruitment by CD28 contributes to or complements TCR-dependent PI3K signaling. Activation of PI3K promotes PIP3 production at the plasma membrane and several potential target molecules for this phospholipid have been implicated in PI3K pathways downstream of the TcR and CD28. Of these targets, at least Vav and Akt have been implicated in CD28 costimulation of T cell activation. AKT/PKB connects PI3K to signaling pathways that promote cytokine transcription, survival, cell-cycle entry and growth.

UnificationXref8240
type: UnificationXref
id: REACT_3746
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3746.2

UnificationXref8241
type: UnificationXref
id: CHEBI:17821
db: ChEBI

UnificationXref8242
type: UnificationXref
id: 83960
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83960

UnificationXref8243
type: UnificationXref
id: REACT_4218
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4218.2

http://identifiers.org/pubmed/1703535
type: PublicationXref
id: 1703535
author: Purdue, PE
author: Danpure, CJ
author: Takada, Y
db: Pubmed
title: Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1
source: J Cell Biol 111:2341-51
year: 1990

http://identifiers.org/pubmed/11863375
type: PublicationXref
id: 11863375
author: Yang, RZ
author: Shuldiner, AR
author: Gong, DW
author: Blaileanu, G
author: Hansen, BC
db: Pubmed
title: cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase
source: Genomics 79:445-50
year: 2002

UnificationXref8238
type: UnificationXref
id: CHEBI:16040
db: ChEBI

UnificationXref8237
type: UnificationXref
id: REACT_82010
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82010.9

UnificationXref8239
type: UnificationXref
id: 83924
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83924

http://identifiers.org/pubmed/16319917
type: PublicationXref
id: 16319917
author: Newman, SC
author: Radomski, MW
author: Jurasz, P
author: Lara, N
author: Le Mellédo, JM
author: Baker, G
author: Archer, SL
author: Chrapko, W
db: Pubmed
title: Alteration of decreased plasma NO metabolites and platelet NO synthase activity by paroxetine in depressed patients
source: Neuropsychopharmacology 31:1286-93
year: 2006

UnificationXref8234
type: UnificationXref
id: P31381
db: UniProt

UnificationXref8233
type: UnificationXref
id: REACT_8580
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_8580.1

UnificationXref8236
type: UnificationXref
id: 3668317
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668317

UnificationXref8235
type: UnificationXref
id: 3668315
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668315

http://identifiers.org/pubmed/11470436
type: PublicationXref
id: 11470436
author: Otwinowski, Z
author: Kojima, K
author: Ito, A
author: Miyaura, H
author: Taylor, AB
author: Kitada, S
author: Deisenhofer, J
author: Smith, BS
db: Pubmed
title: Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences
source: Structure 9:615-25
year: 2001

UnificationXref8253
type: UnificationXref
id: 83955
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83955

UnificationXref8254
type: UnificationXref
id: REACT_4158
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4158.2

UnificationXref8251
type: UnificationXref
id: 83918
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83918

UnificationXref8252
type: UnificationXref
id: REACT_5362
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5362.2

UnificationXref8250
type: UnificationXref
id: REACT_2296
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2296.2

YFH1
type: ProteinReference
name: UniProt:Q07540 YFH1
name: YDL120W
xref: UnificationXref878
comment: FUNCTION Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain.CATALYTIC ACTIVITY 4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.SUBUNIT Monomer; increments in mitochondrial iron uptake induce stepwise assembly of species ranging from trimers to 24-mers. Interacts with ISU1. Interacts with YHB1, SDH1, SDH2, AIM45 and CIR1.PTM Processed in two steps by mitochondrial processing peptidase (MPP). MPP first cleaves the precursor to intermediate form and subsequently converts the intermediate to mature size protein.MISCELLANEOUS Present with 1560 molecules/cell in log phase SD medium.SIMILARITY Belongs to the frataxin family.
organism: BioSource1

http://identifiers.org/pubmed/12881475
type: PublicationXref
id: 12881475
author: Koesling, D
author: Friebe, A
db: Pubmed
title: Regulation of nitric oxide-sensitive guanylyl cyclase
source: Circ Res 93:96-105
year: 2003

UnificationXref8249
type: UnificationXref
id: 83947
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83947

UnificationXref8248
type: UnificationXref
id: REACT_8574
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_8574.1

UnificationXref8247
type: UnificationXref
id: 179742
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179742

UnificationXref8246
type: UnificationXref
id: REACT_4964
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4964.2

UnificationXref8245
type: UnificationXref
id: 83962
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83962

UnificationXref8244
type: UnificationXref
id: CHEBI:17568
db: ChEBI

UnificationXref8220
type: UnificationXref
id: 83908
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83908

UnificationXref8221
type: UnificationXref
id: REACT_5567
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5567.3

http://identifiers.org/pubmed/11435118
type: PublicationXref
id: 11435118
author: Timm, DE
author: Harris, RA
author: Dorocke, JA
author: Baker, LJ
db: Pubmed
title: The crystal structure of yeast thiamin pyrophosphokinase
source: Structure 9:539-46
year: 2001

UnificationXref8219
type: UnificationXref
id: REACT_8358
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_8358.1

UnificationXref8212
type: UnificationXref
id: REACT_103751
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103751.9

UnificationXref8211
type: UnificationXref
id: 3673513
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673513

UnificationXref8214
type: UnificationXref
id: REACT_82675
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82675.9

UnificationXref8213
type: UnificationXref
id: 3673389
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673389

UnificationXref8216
type: UnificationXref
id: 83928
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83928

UnificationXref8215
type: UnificationXref
id: CHEBI:17748
db: ChEBI

UnificationXref8218
type: UnificationXref
id: 179746
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179746

UnificationXref8217
type: UnificationXref
id: REACT_5250
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5250.2

UnificationXref8231
type: UnificationXref
id: REACT_2401
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2401.2

UnificationXref8232
type: UnificationXref
id: 179745
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179745

http://identifiers.org/pubmed/16543383
type: PublicationXref
id: 16543383
author: Pollard, JW
author: Pollack, SE
author: Cohen, PE
db: Pubmed
title: Genetic analysis of chromosome pairing, recombination, and cell cycle control during first meiotic prophase in mammals
source: Endocr Rev 27:398-426
year: 2006

UnificationXref8230
type: UnificationXref
id: 83923
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83923

UniProt:Q07560
type: ProteinReference
xref: UnificationXref4243
organism: BioSource1

S Phase
type: Pathway
data source: Provenance1
pathway component: REACT 29575.10
evidence: Evidence112
xref: UnificationXref1230
xref: UnificationXref1231
xref: RelationshipXref74
pathway order: PathwayStep116
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8225
type: UnificationXref
id: REACT_3375
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3375.2

UnificationXref8224
type: UnificationXref
id: 83920
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83920

UnificationXref8223
type: UnificationXref
id: REACT_4381
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4381.2

UnificationXref8222
type: UnificationXref
id: 83948
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83948

UnificationXref8229
type: UnificationXref
id: REACT_5346
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5346.2

UnificationXref8228
type: UnificationXref
id: 83922
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83922

UnificationXref8227
type: UnificationXref
id: REACT_4660
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4660.2

UnificationXref8226
type: UnificationXref
id: 83921
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83921

Signaling by Rho GTPases
type: Pathway
data source: Provenance1
pathway component: Rho GTPase cycle
evidence: Evidence1171
xref: UnificationXref8691
xref: RelationshipXref1057
xref: UnificationXref8692
pathway order: PathwayStep1177
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Pyridoxine phosphate [ChEBI:8672]
type: SmallMoleculeReference
name: Pyridoxine 5-phosphate
name: Pyridoxine phosphate
name: Pyridoxine 5'-phosphate
xref: UnificationXref5576

dITP
type: SmallMoleculeReference
name: 2'-Deoxyinosine 5'-triphosphate
name: dITP [ChEBI:10499]
name: 2'-Deoxyinosine-5'-triphosphate
xref: UnificationXref5447

http://identifiers.org/pubmed/11498013
type: PublicationXref
id: 11498013
author: Sorkin, A
db: Pubmed
title: Internalization of the epidermal growth factor receptor: role in signalling
source: Biochem Soc Trans 29:480-4
year: 2001

2'-Deoxyinosine 5'-phosphate [ChEBI:28806]
type: SmallMoleculeReference
name: 2'-Deoxyinosine 5'-phosphate
name: dIMP
xref: UnificationXref5450

http://identifiers.org/pubmed/11278778
type: PublicationXref
id: 11278778
author: Trimble, RB
author: Cipollo, JF
author: Yan, Q
author: Dean, N
author: Chi, JH
db: Pubmed
title: The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum
source: J Biol Chem 276:21828-40
year: 2001

Metabolism of vitamins and cofactors
type: Pathway
data source: Provenance1
pathway component: REACT 102551.9
evidence: Evidence736
xref: UnificationXref5771
xref: RelationshipXref701
xref: UnificationXref5770
pathway order: PathwayStep737
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

PublicationXref1480
type: PublicationXref
author: Parkinson, A
title: Casarett and Doull's Toxicology 5th Edn
source: 113-186
year: 1995

http://identifiers.org/pubmed/15272052
type: PublicationXref
id: 15272052
author: Dinh, TP
author: Piomelli, D
author: Kathuria, S
db: Pubmed
title: RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol
source: Mol Pharmacol 66:1260-4
year: 2004

http://identifiers.org/pubmed/10903473
type: PublicationXref
id: 10903473
author: Sprecher, H
db: Pubmed
title: Metabolism of highly unsaturated n-3 and n-6 fatty acids
source: Biochim Biophys Acta 1486:219-31
year: 2000

http://identifiers.org/pubmed/18802471
type: PublicationXref
id: 18802471
author: Jefferies, WA
author: Seipp, RP
author: Basha, G
author: Omilusik, KD
author: Lizée, G
author: Reinicke, AT
db: Pubmed
title: MHC class I endosomal and lysosomal trafficking coincides with exogenous antigen loading in dendritic cells
source: PLoS One 3:e3247
year: 2008

http://identifiers.org/pubmed/17177598
type: PublicationXref
id: 17177598
author: DeBiasi, RM
author: Leahy, DJ
author: Paez, JG
author: Yoshimoto, K
author: O'Neill, K
author: Thomas, RK
author: Cloughesy, T
author: Greulich, H
author: Yuza, Y
author: Ziaugra, L
author: Vivanco, I
author: Levine, RL
author: Rao, PN
author: Xu, Q
author: Gabriel, S
author: Onofrio, R
author: Lee, JC
author: Glatt, KA
author: Nghiemphu, P
author: Peck, TC
author: Liau, LM
author: Huang, JHY
author: Beroukhim, R
author: King, JC
author: Linhart, DJ
author: Kawaguchi, T
author: Sellers, WR
author: Mellinghoff, IK
author: Meyerson, M
author: Feng, WL
author: Getz, G
author: Nelson, SF
author: Mischel, P
author: Sawyers, CL
author: Pieper, RO
author: Khan, H
db: Pubmed
title: Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain
source: PLoS Med 3:e485
year: 2006

http://identifiers.org/pubmed/19338303
type: PublicationXref
id: 19338303
author: Han, Q
author: Robinson, H
author: Tagle, DA
author: Cai, T
author: Li, J
db: Pubmed
title: Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K
source: J Med Chem 52:2786-93
year: 2009

http://identifiers.org/pubmed/1968462
type: PublicationXref
id: 1968462
author: Edwards, PA
author: Kutsunai, SY
author: Wilkin, DJ
db: Pubmed
title: Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester
source: J Biol Chem 265:4607-14
year: 1990

Mitochondrial Protein Import
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction38
pathway component: BiochemicalReaction27
pathway component: BiochemicalReaction34
pathway component: BiochemicalReaction30
pathway component: BiochemicalReaction28
pathway component: BiochemicalReaction31
pathway component: BiochemicalReaction29
pathway component: BiochemicalReaction36
pathway component: BiochemicalReaction35
pathway component: BiochemicalReaction33
pathway component: BiochemicalReaction37
pathway component: BiochemicalReaction32
evidence: Evidence1417
xref: RelationshipXref1206
xref: UnificationXref9801
xref: UnificationXref9802
pathway order: PathwayStep68
pathway order: PathwayStep66
pathway order: PathwayStep59
pathway order: PathwayStep62
pathway order: PathwayStep61
pathway order: PathwayStep70
pathway order: PathwayStep69
pathway order: PathwayStep60
pathway order: PathwayStep67
pathway order: PathwayStep63
pathway order: PathwayStep65
pathway order: PathwayStep64
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:Q3E792
type: ProteinReference
xref: UnificationXref1710
organism: BioSource1

mRNA Splicing - Minor Pathway
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction129
pathway component: BiochemicalReaction131
pathway component: BiochemicalReaction130
pathway component: BiochemicalReaction132
evidence: Evidence263
xref: UnificationXref2509
xref: RelationshipXref150
xref: UnificationXref2510
pathway order: PathwayStep261
pathway order: PathwayStep259
pathway order: PathwayStep260
pathway order: PathwayStep258
display name: U12 Dependent Splicing
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Mitotic Prometaphase
type: Pathway
data source: Provenance1
pathway component: REACT 156804.3
evidence: Evidence27
xref: UnificationXref196
xref: UnificationXref197
xref: RelationshipXref22
pathway order: PathwayStep22
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/7874169
type: PublicationXref
id: 7874169
author: Pulleyn, LJ
author: Schinzel, A
author: Losken, HW
author: Malcolm, S
author: Muenke, M
author: Schell, U
author: Reardon, W
author: Rutland, P
author: Robin, NH
author: Hehr, A
db: Pubmed
title: A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome
source: Nat Genet 8:269-74
year: 1994

RNA Pol II CTD phosphorylation and interaction with CE
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction608
pathway component: BiochemicalReaction121
pathway component: BiochemicalReaction120
pathway component: BiochemicalReaction609
evidence: Evidence918
xref: UnificationXref7243
xref: UnificationXref7242
pathway order: PathwayStep245
pathway order: PathwayStep244
pathway order: PathwayStep929
pathway order: PathwayStep928
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/18653779
type: PublicationXref
id: 18653779
author: Sandahl, MA
author: Miraglia, L
author: Hunter, D
author: Earp HS, 3rd
author: Muraoka-Cook, RS
db: Pubmed
title: Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation
source: Mol Endocrinol 22:2307-21
year: 2008

http://identifiers.org/pubmed/2241899
type: PublicationXref
id: 2241899
author: Doyle, JM
author: Bossa, F
author: Doonan, S
author: Schinina, ME
db: Pubmed
title: The amino acid sequence of cytosolic aspartate aminotransferase from human liver
source: Biochem J 270:651-7
year: 1990

dCDP
type: SmallMoleculeReference
name: dCDP [ChEBI:28846]
name: 2'-Deoxycytidine diphosphate
name: 2'-Deoxycytidine 5'-diphosphate
xref: UnificationXref5367

http://identifiers.org/pubmed/17463226
type: PublicationXref
id: 17463226
author: Puggioni, EM
author: Cesareni, G
author: Gulino, A
author: Santangelo, L
author: Belleudi, F
author: Palumbo, C
author: Frati, L
author: Marrocco, J
author: Omerovic, J
author: Torrisi, MR
author: Di Marcotullio, L
author: Alimandi, M
author: Dall'Armi, C
db: Pubmed
title: The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation
source: FASEB J 21:2849-62
year: 2007

UniProt:P24868
type: ProteinReference
xref: UnificationXref111
organism: BioSource1

5'-Phosphoribosyl-5-aminoimidazole [ChEBI:28843]
type: SmallMoleculeReference
name: 5'-Phosphoribosyl-5-aminoimidazole
name: Aminoimidazole ribotide
name: 1-(5'-Phosphoribosyl)-5-aminoimidazole
name: 1-(5-Phospho-D-ribosyl)-5-aminoimidazole
name: AIR
xref: UnificationXref5050

http://identifiers.org/pubmed/17170135
type: PublicationXref
id: 17170135
author: Li, JL
author: Gimeno, RE
author: Li, D
author: Tobin, JF
author: Cao, J
db: Pubmed
title: Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis
source: Proc Natl Acad Sci U S A 103:19695-700
year: 2006

UniProt:P24869
type: ProteinReference
xref: UnificationXref109
organism: BioSource1

Lipid digestion, mobilization, and transport
type: Pathway
data source: Provenance1
pathway component: REACT 90788.9
pathway component: REACT 87252.9
evidence: Evidence366
xref: UnificationXref3302
xref: UnificationXref3303
pathway order: PathwayStep361
pathway order: PathwayStep363
display name: Lipid and lipoprotein metabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Proline catabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction506
pathway component: BiochemicalReaction505
evidence: Evidence767
xref: UnificationXref5978
xref: RelationshipXref739
xref: UnificationXref5977
pathway order: PathwayStep768
pathway order: PathwayStep767
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/8567683
type: PublicationXref
id: 8567683
author: Beardsley, GP
author: Moroson, BA
author: Rayl, EA
db: Pubmed
title: The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
source: J Biol Chem 271:2225-2233
year: 1996

dUDP [ChEBI:28850]
type: SmallMoleculeReference
name: 2'-Deoxyuridine 5'-diphosphate
name: dUDP
xref: UnificationXref5396

UniProt:P24870
type: ProteinReference
xref: UnificationXref107
organism: BioSource1

UniProt:P24871
type: ProteinReference
xref: UnificationXref115
organism: BioSource1

PublicationXref1475
type: PublicationXref
author: Oesch, F
author: Arand, M
title: Toxicology
source: 83-107
year: 1999

http://identifiers.org/pubmed/18762715
type: PublicationXref
id: 18762715
author: Ohta, KY
author: Yuasa, H
author: Inoue, K
author: Ishii, M
author: Katano, T
author: Watanabe, J
author: Ohgusu, Y
author: Urano, K
db: Pubmed
title: Functional characterization of human aquaporin 9 as a facilitative glycerol carrier
source: Drug Metab Pharmacokinet 23:279-84
year: 2008

http://identifiers.org/pubmed/12855817
type: PublicationXref
id: 12855817
author: Sato, S
author: Takeda, K
author: Takeuchi, O
author: Sanjo, H
author: Sugiyama, M
author: Hoshino, K
author: Kaisho, T
author: Hemmi, H
author: Okabe, M
author: Yamamoto, M
db: Pubmed
title: Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
source: Science 301:640-3
year: 2003

UniProt:P14126
type: ProteinReference
xref: UnificationXref1484
organism: BioSource1

UniProt:P14127
type: ProteinReference
xref: UnificationXref1661
organism: BioSource1

UniProt:P14120
type: ProteinReference
xref: UnificationXref1562
organism: BioSource1

http://identifiers.org/pubmed/7641697
type: PublicationXref
id: 7641697
author: Nasmyth, K
author: Lengauer, C
author: Piatti, S
db: Pubmed
title: Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae.
source: EMBO J 14:3788-99
year: 1995

UniProt:P0C0T4
type: ProteinReference
xref: UnificationXref1712
organism: BioSource1

2'-Deoxyguanosine 5'-diphosphate
type: SmallMoleculeReference
name: dGDP [ChEBI:28862]
name: dGDP
xref: UnificationXref5383

O-Propanoylcarnitine
type: SmallMoleculeReference
name: O-Propionylcarnitine
name: O-Propanoylcarnitine [ChEBI:7701]
xref: UnificationXref3597

YOR224C
type: ProteinReference
name: UniProt:P20436 RPB8
name: YOR50-14
name: RPB8
xref: UnificationXref2307
comment: FUNCTION DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.SUBUNIT Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of 14, 12 and 17 subunits, respectively. Directly interacts with POLR2A.MISCELLANEOUS Present with 6210 molecules/cell in log phase SD medium.SIMILARITY Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
organism: BioSource1

http://identifiers.org/pubmed/11429702
type: PublicationXref
id: 11429702
author: Colombo, G
author: Dell'Era, P
author: Neri, A
author: Lombardi, L
author: Greco, A
author: Otsuki, T
author: Ronchetti, D
author: Compasso, S
db: Pubmed
title: Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations
source: Oncogene 20:3553-62
year: 2001

UniProt:P0C0V8
type: ProteinReference
xref: UnificationXref1717
organism: BioSource1

Sphingolipid metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 142637.5
pathway component: REACT 146670.5
evidence: Evidence581
xref: UnificationXref4670
xref: UnificationXref4669
xref: RelationshipXref494
pathway order: PathwayStep578
pathway order: PathwayStep575
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:P0C0W9
type: ProteinReference
xref: UnificationXref1417
organism: BioSource1

UniProt:P0C0X0
type: ProteinReference
xref: UnificationXref1629
organism: BioSource1

UniProt:P20459
type: ProteinReference
xref: UnificationXref1598
organism: BioSource1

http://identifiers.org/pubmed/1976634
type: PublicationXref
id: 1976634
author: Hurwitz, J
author: Lee, SH
author: Kwong, AD
db: Pubmed
title: The in vitro replication of DNA containing the SV40 origin.
source: J Biol Chem 265:18043-6
year: 1990

http://identifiers.org/pubmed/7913309
type: PublicationXref
id: 7913309
author: Rokosz, LL
author: Cueto, MA
author: Butkiewicz, EA
author: Hermes, JD
author: Boulton, DA
author: Sanyal, G
author: Lachance, PA
db: Pubmed
title: Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes
source: Arch Biochem Biophys 312:1-13
year: 1994

UniProt:P20433
type: ProteinReference
xref: UnificationXref2303
organism: BioSource1

UniProt:P20434 RPB5
type: ProteinReference
name: RPC9
name: YBR154C
name: YBR1204
name: RPA7
name: RPB5
xref: UnificationXref2319
comment: SUBUNIT Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 14, 12 and 17 subunits, respectively.SIMILARITY Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
organism: BioSource1

P9677.8
type: ProteinReference
name: UniProt:P20435 RPO26
name: YPR187W
name: RPO26
name: RPB6
xref: UnificationXref2313
comment: MISCELLANEOUS Present with 6090 molecules/cell in log phase SD medium.SIMILARITY Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.
organism: BioSource1

http://identifiers.org/pubmed/19244215
type: PublicationXref
id: 19244215
author: Buczynski, MW
author: Dumlao, DS
author: Dennis, EA
db: Pubmed
title: Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology
source: J Lipid Res 50:1015-38
year: 2009

Evidence1300
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Proteasomes are usually localized to the cytoplasm but are also present in the nucleus and ER. Houde et al. (2003) investigated the distribution of proteasomes in J774 macrophages and observed them on phagosomes. The proteasomes present on phagosomes may not come directly from ER, but instead assemble on phagosomes to play a function at a precise point during phagolysosomal biogenesis. Houde et al. also observed polyubiquitinated proteins on the cytoplasmic side of phagosomes and highlighted the link between the ubiquitination process and proteasomal degradation; translocated peptides are ubiquitinated and processed by the proteasome complex assembled on the cytoplasmic side of phagosomes, leading to the generation of MHC class I binding peptides.

Evidence1304
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19218463
xref: http://identifiers.org/pubmed/16181333
xref: http://identifiers.org/pubmed/15761154
xref: http://identifiers.org/pubmed/16181335
xref: http://identifiers.org/pubmed/20171863
xref: http://identifiers.org/pubmed/17157489
comment: MHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment can be presented on MHC class I to stimulate CD8+ T cell immunity, a process termed cross-presentation (Rock & Shen. 2005). Cross-presentation/cross-priming is the ability of antigen presenting cells (APCs) to present exogenous antigens on MHC class I molecules to CD8+ T lymphocytes. Among all the APCs, Dendritic cells (DC) are the dominant antigen cross presenting cell types in vivo, although macrophages and B cells appear to cross present model antigens in vitro with a low degree of efficiency (Amigorena & Savina. 2010, Ackermann & Peter Cresswell. 2004). Compared to macrophages, DCs have low levels of lysosomal proteases and exhibit limited lysosomal degradation (Delamarre et al. 2005). This limited proteolysis of internalized antigens by DCs might contribute to their high efficiency for cross presentation (Monua & Trombetta. 2007). APCs acquire the exogenous antigens through endocytic mechanisms, especially phagosomes for particulate/cell-associated antigens and endosomes for soluble protein antigens. There does not seem to be a unique pathway for cross-presentation but rather different potential mechanisms of cross-presentation have been proposed. These proposed pathways can be classified according to the location where two key events occur: 1) processing of the antigenic protein and 2) loading of the processed peptide on to MHC I molecule (Blanchard & Shastri. 2010). Based on the requirement for TAP and cytosolic proteases two mechanisms have been described, a cytosolic pathway (TAP-dependent and proteasome-dependent) or a vacuolar pathway (TAP- and proteasome-independent) (Blanchard & Shastri. 2010, Amigorena & Savina. 2010). Regarding peptide-loading, MHC I could be loaded in the ER or in the phagosome and recycled to cell surface (Blanchard & Shastri. 2010). Exo…

http://identifiers.org/pubmed/12648452
type: PublicationXref
id: 12648452
author: Buttgereit, F
author: Qian, SB
author: Finzi, D
author: Princiotta, MF
author: Yewdell, JW
author: Gibbs, J
author: Bennink, JR
author: Schuchmann, S
db: Pubmed
title: Quantitating protein synthesis, degradation, and endogenous antigen processing
source: Immunity 18:343-54
year: 2003

Evidence1303
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20171863
xref: http://identifiers.org/pubmed/17157489
xref: http://identifiers.org/pubmed/15592474
comment: Exogenous soluble antigens are cross-presented by dendritic cells, albeit with lower efficiency than for particulate substrates. Soluble antigens destined for cross-presentation are taken up by distinct endocytosis mechanisms which route them into stable early endosomes and then to the cytoplasm for proteasomal degradation and peptide loading.

Evidence1302
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16818754
xref: http://identifiers.org/pubmed/20028659
comment: Exogenous antigens are thought to be processed for cross-presentation in much the same manner as endogenous proteins once they enter the cytosolic pathway (Rock et al. 2010). Immunoproteasome components are the major proteases involved in generating the antigenic fragments. The precurssor peptides are further trimmed by cytosolic aminopeptidases and shuttled to ER through TAP for MHC class I loading.

Evidence1301
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15728715
xref: http://identifiers.org/pubmed/14508490
xref: http://identifiers.org/pubmed/17027300
xref: http://identifiers.org/pubmed/14508489
xref: http://identifiers.org/pubmed/20171863
xref: http://identifiers.org/pubmed/18006660
xref: http://identifiers.org/pubmed/15845646
xref: http://identifiers.org/pubmed/14561893
xref: http://identifiers.org/pubmed/12151002
xref: http://identifiers.org/pubmed/18802471
xref: http://identifiers.org/pubmed/12669019
xref: http://identifiers.org/pubmed/16213220
comment: The other TAP-dependent cross-presentation mechanism in phagocytes is the endoplasmic reticulum (ER)-phagosome model. Desjardins proposed that ER is recruited to the cell surface, where it fuses with the plasma membrane, underneath phagocytic cups, to supply membrane for the formation of nascent phagosomes (Gagnon et al. 2002). Three independent studies simultaneously showed that ER contributes to the vast majority of phagosome membrane (Guermonprez et al. 2003, Houde et al. 2003, Ackerman et al. 2003). The composition of early phagosome membrane contains ER-resident proteins, the components required for cross-presentation. This model is similar to the phagosome-to-cytosol model in that Ag is translocated to cytosol for proteasomal degradation, but differs in that antigenic peptides are translocated back into the phagosome (instead of ER) for peptide:MHC-I complexes. ER fusion with phagosome introduces molecules that are involved in Ag transport to cytosol (Sec61) and proteasome-generated peptides back into the phagosome (TAP) for loading onto MHC-I. Through extensive biochemical assays, fluorescent imaging and electron microscopy-based experiments, most of the evidence in favor of ER-phagocytosis has been challenged (Touret et al. 2005a/b). Using quantitative proteomics Roger and Foster have shown that the percentage of PM and ER membranes on phagosomes 10 min after internalization was approximately 10% and 0.2% (Rogers et al. 2007). They concluded that ER contributes only a small part of phagosomal membranes. Although the ER-phagosome pathway is controversial, the concept remains attractive as it explains how peptide-receptive MHC-I molecules could intersect with a relatively high concentration of exogenous antigens, presumably a crucial prerequisite for efficient cross-presentation (Basha et al. 2008).

Evidence1308
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18332149
xref: http://identifiers.org/pubmed/15728506
comment: Little is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may also heterodimerize with TLRs 1 and 2. It is expressed in a restricted fashion as a highly N-glycosylated protein detectable in B cells and dendritic cells.

Evidence1307
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9430229
xref: http://identifiers.org/pubmed/10435584
xref: http://identifiers.org/pubmed/16239509
xref: http://identifiers.org/pubmed/15728506
comment: Mammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of TLR3, can initiate downstream signaling trough MyD88. In the MyD88 - dependent pathway, once the adaptor is bound to TLR it leads to recruitment of IL1 receptor associated kinase family â IRAK which is followed by activation of tumour necrosis factor receptor-associated factor 6 (TRAF6) . TRAF6 is an ubiquitin E3 ligase which in turn induces TGF-beta activating kinase 1 (TAK1) auto phosphorylation. Once activated TAK1 can ultimately mediate the induction of the transcription factor NF-kB or the mitogen-activated protein kinases (MAPK), such as JNK, p38 and ERK. This results in the translocation of the activated NF-kB and MAPKs to the nucleus and the initiation of appropriate gene transcription leading to the production of many proinflammatory cytokines and antimicrobial peptides.

Evidence1306
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/21682741
xref: http://identifiers.org/pubmed/11861602
xref: http://identifiers.org/pubmed/16551257
comment: Adaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with remarkable diversity tailored to recognize aspects of particular pathogens or antigens. During infection, dendritic cells (DC) which act as sentinels in the peripheral tissues recognize and pick up the pathogen in the form of antigenic determinants and then process these antigens and present them to T cells. These T cells of appropriate specificity respond to the antigen, and either kill the pathogen directly or secrete cytokines that will stimulate B lymphocyte response. B cells provide humoral immunity by secreting antibodies specific for the pathogen or antigen.

Evidence1305
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18641646
xref: http://identifiers.org/pubmed/18926908
xref: http://identifiers.org/pubmed/17055423
xref: http://identifiers.org/pubmed/18243674
xref: http://identifiers.org/pubmed/12495737
xref: http://identifiers.org/pubmed/17145306
xref: http://identifiers.org/pubmed/8717519
xref: http://identifiers.org/pubmed/19261456
comment: Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells that are synthesizing abnormal or foreign proteins. MHC class I is a trimeric complex composed of a polymorphic heavy chain (HC or alpha chain) and an invariable light chain, known as beta2-microglobulin (B2M) plus an 8-10 residue peptide ligand. Represented here are the events in the biosynthesis of MHC class I molecules, including generation of antigenic peptides by the ubiquitin/26S-proteasome system, delivery of these peptides to the endoplasmic reticulum (ER), loading of peptides to MHC class I molecules and display of MHC class I complexes on the cell surface.

http://identifiers.org/pubmed/17371050
type: PublicationXref
id: 17371050
author: Kondo, N
author: Fukao, T
author: Haapalainen, AM
author: Wierenga, RK
author: Meriläinen, G
author: Pirilä, PL
db: Pubmed
title: Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function
source: Biochemistry 46:4305-21
year: 2007

PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
type: Pathway
data source: Provenance1
pathway component: Hypusine synthesis from eIF5A-lysine
evidence: Evidence1366
xref: RelationshipXref1141
xref: UnificationXref9423
xref: UnificationXref9424
pathway order: PathwayStep1367
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence1309
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15814722
xref: http://identifiers.org/pubmed/12855817
xref: http://identifiers.org/pubmed/14739303
comment: TRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists of an N-terminal region (1-234), a TIR domain (235-500), and a C-terminal region (501-680). The N-terminal region of TRIF harbors TRAF (TNF receptor associated factor) family proteins and forms complexes containing IRF-3 and/or NFkB -activating kinases. The C-terminal region of TRIF can recruit receptor-interacting protein-1 (RIP-1), and this event is followed by the activation of IKK complex.

Metal ion SLC transporters
type: Pathway
data source: Provenance1
pathway component: REACT 135276.5
pathway component: BiochemicalReaction698
evidence: Evidence1074
xref: UnificationXref8211
xref: UnificationXref8212
pathway order: PathwayStep1080
pathway order: PathwayStep1081
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:P20424
type: ProteinReference
xref: UnificationXref7767
organism: BioSource1

http://identifiers.org/pubmed/11134326
type: PublicationXref
id: 11134326
author: Intine, RV
author: Maraia, RJ
db: Pubmed
title: Recognition of nascent RNA by the human La antigen: conserved and divergent features of structure and function.
source: Mol Cell Biol 21:367-79
year: 2001

http://identifiers.org/pubmed/9852097
type: PublicationXref
id: 9852097
author: Kerr, TA
author: Russell, DW
author: Li, WP
author: Sakai, J
author: Lund, EG
db: Pubmed
title: cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
source: J Biol Chem 273:34316-27
year: 1998

http://identifiers.org/pubmed/12176987
type: PublicationXref
id: 12176987
author: Tanabe, K
author: Tanaka, AR
author: Ueda, K
author: Morita, M
author: Kurisu, M
author: Matsuo, M
author: Kasiwayama, Y
author: Kioka, N
author: Imanaka, T
author: Amachi, T
db: Pubmed
title: ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1)
source: J Biol Chem 277:40142-7
year: 2002

http://identifiers.org/pubmed/11698644
type: PublicationXref
id: 11698644
author: Kabashima, T
author: Uyeda, K
author: Kawaguchi, T
author: Takenoshita, M
db: Pubmed
title: Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein
source: Proc Natl Acad Sci U S A 98:13710-5
year: 2001

Evidence1327
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14761955
comment: The ubiquitin ligaseâassociated protein SGT1 (SUGT1) has two putative HSP90 binding domains, a tetratricopeptide repeat and a p23-like CHORD and Sgt1 (CS) domain. The CS domain of human SGT1 physically interacts with HSP90. SGT1 and related proteins are believed to recruit heat shock proteins to multiprotein assemblies (Lee et al. 2004).

Evidence1328
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20303873
xref: http://identifiers.org/pubmed/15075209
xref: http://identifiers.org/pubmed/12766759
xref: http://identifiers.org/pubmed/19501527
xref: http://identifiers.org/pubmed/11607846
xref: http://identifiers.org/pubmed/17036048
xref: http://identifiers.org/pubmed/18604214
xref: http://identifiers.org/pubmed/16498449
comment: The NLRP3 (Cryopyrin) inflammasome is currently the best characterized. It consists of NLRP3, ASC (PYCARD) and procaspase-1; CARD8 (Cardinal) is also suggested to be a component. It is activated by a number of pathogens and bacterial toxins as well as diverse PAMPs, danger-associated molecular patterns (DAMPS) such as hyaluronan and uric acid, and exogenous irritants such as silica and asbestos (see Table S1 Schroder & Tschopp, 2010). Mutations in NLRP3 which lead to constitutive activation are linked to the human diseases Muckle-Wells syndrome, familial cold autoinflammatory syndrome and NOMID (Ting et al. 2006), characterized by skin rashes and other symptoms associated with generalized inflammation. The cause of these symptoms is uncontrolled IL-1 beta production. Multiple studies have shown that activation of the NLRP3 inflammasome by particulate activators (e.g. Hornung et al. 2008) requires phagocytosis, but this is not required for the response to ATP, which is mediated by the P2X7 receptor (Kahlenberg & Dubyak, 2004) and appears to involve the pannexin membrane channel (Pellegrin & Suprenenant 2006). Direct binding of activators to NLRP3 has not been demonstrated and the exact process of activation is unclear, though it is speculated to involve changes in conformation that free the NACHT domain for oligomerization (Inohara & Nunez 2001, 2003).

Evidence1329
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19120480
xref: http://identifiers.org/pubmed/20303873
xref: http://identifiers.org/pubmed/17186029
xref: http://identifiers.org/pubmed/15162420
xref: http://identifiers.org/pubmed/19302049
xref: http://identifiers.org/pubmed/19120479
xref: http://identifiers.org/pubmed/17164409
xref: http://identifiers.org/pubmed/12620239
comment: In contrast to NOD1/2 some NLRPs function as large macromolecular complexes called 'Inflammasomes'. These multiprotein platforms control activation of the cysteinyl aspartate protease caspase-1 and thereby the subsequent cleavage of pro-interleukin 1B (pro-IL1B) into the active proinflammatory cytokine IL1B. Activation of caspase-1 is essential for production of IL1B and IL18, which respectively bind and activate the IL1 receptor (IL1R) and IL18 receptor (IL18R) complexes. IL1R and IL18R activate NFkappaB and other signaling cascades. As the activation of inflammasomes leads to caspase-1 activation, inflammasomes can be considered an upstream step of the IL1R and IL18R signaling cascades, linking intracellular pathogen sensing to immune response pathways mediated by Toll-Like Receptors (TLRs). Monocytes and macrophages do not express pro-IL1B until stimulated, typically by TLRs (Franchi et al. 2009). The resulting pro-IL1B is not converted to IL1B unless a second stimulus activates an inflammasome. This requirement for two distinct stimuli allows tight regulation of IL1B/IL18 production, necessary because excessive IL-1B production is associated with numerous inflammatory diseases such as gout and rheumatoid arthritis (Masters et al. 2009). There are at least four subtypes of the inflammasome, characterized by the NLRP. In addition the protein AIM2 can form an inflammasome. All activate caspase-1. NLRP1 (NALP1), NLRP3 (Cryopyrin, NALP3), IPAF (CARD12, NLRC4) and AIM2 inflammasomes all have clear physiological roles in vivo. NLRP2, NLRP6, NLRP7, NLRP10 and NLRP12 have been demonstrated to modulate caspase-1 activity in vitro but the significance of this is unclear (Mariathasan and Monack, 2007). NLRP3 and AIM2 bind the protein 'apoptosis-associated speck-like protein containing a CARD' (ASC, also called PYCARD), via a PYD-PYD domain interaction. This in turn recruits procaspase-1 through a CARD-CARD interaction. NLRP1 and IPAF contain CARD domains and can bind procas…

Evidence1323
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10820283
comment: TLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at least some other TLR2 ligands may be assisted by additional accessory proteins, particularly in association with TLR1 or TLR6. TLR2 is expressed constitutively on macrophages, dendritic cells, and B cells, and can be induced in some other cell types, including epithelial cells. TLR1 and TLR6, on the other hand, are expressed almost ubiquitously (Muzio et al. 2000). TLR2 may be a sensor and inductor of specific defense processes, including oxidative stress and cellular necrosis initially spurred by microbial compounds.

UnificationXref8149
type: UnificationXref
id: REACT_19505
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19505.1

Evidence1324
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14751757
xref: http://identifiers.org/pubmed/12893815
xref: http://identifiers.org/pubmed/15976490
xref: http://identifiers.org/pubmed/15585605
xref: http://identifiers.org/pubmed/15950447
comment: In human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) domain in their cytoplasmic region and an Ig-like domain in the extracellular region, where each is enriched with a varying number of leucine-rich repeats (LRRs). Each TLR can recognize specific microbial pathogen components. The binding pathogenic component to TLR initializes signaling pathways that lead to induction of Interferon alpha/beta and inflammatory cytokines. There are two main signaling pathways. The first is a MyD88-dependent pathway that is common to all TLRs, except TLR3; the second is a TRIF(TICAM1)-dependent pathway that is peculiar to TLR3 and TLR4. TLR4-mediated signaling pathway via TRIF requires adapter molecule TRAM (TRIF-related adapter molecule or TICAM2). TRAM is thought to bridge between the activated TLR4 complex and TRIF.(Takeda & Akira 2004; Akira 2003; Takeda & Akira 2005; Kawai 2005; Heine & Ulmer 2005).

Evidence1325
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8663524
xref: http://identifiers.org/pubmed/10066767
xref: http://identifiers.org/pubmed/9430721
xref: http://identifiers.org/pubmed/15686620
xref: http://identifiers.org/pubmed/7693711
xref: http://identifiers.org/pubmed/8633070
comment: p38 MAPK has 4 representative isoforms in humans, p38 alpha (Han et al. 1993), p38-beta (Jiang et al. 1996), p38-gamma (Lechner et al. 1996) and p38-delta (Hu et al. 1999). All are activated by phosphorylation on a canonical TxY motif by the dual-specificity kinase MKK6, which displays minimal substrate selectivity amongst the p38 isoforms (Zarubin & Han, 2005). p38 alpha and gamma are also activated by MKK3.

Evidence1326
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18585455
xref: http://identifiers.org/pubmed/15952891
xref: http://identifiers.org/pubmed/18414735
xref: http://identifiers.org/pubmed/17348859
xref: http://identifiers.org/pubmed/18928408
xref: http://identifiers.org/pubmed/18342009
xref: http://identifiers.org/pubmed/18079694
comment: NOD1 is ubiquitously expressed, while NOD2 expression is restricted to monocytes, macrophages, dendritic cells, and intestinal Paneth cells (Inohara et al. 2005). NOD1 and NOD2 activation induces transcription of immune response genes, predominantly mediated by the proinflammatory transcriptional factor NFkappaB but also by AP-1 and Elk-1 (Inohara et al. 2005). NFkappaB translocates to the nucleus following release from IkappaB proteins. NOD1 and NOD2 signaling involves an interaction between their caspase-recruitment domain (CARD) and the CARD of the kinase RIPK2 (RIP2/RICK). This leads to the activation of the NFkappaB pathway and MAPK pathways (Windheim et al. 2007). Activated NODs oligomerize via their NACHT domains, inducing physical proximity of RIP2 proteins that is believed to trigger their K63-linked polyubiquitination, facilitating recruitment of the TAK1 complex. RIP2 also recruits NEMO, bringing the TAK1 and IKK complexes into proximity, leading to NF-kappaB activation and activation of MAPK signaling. Recent studies have demonstrated that K63-linked regulatory ubiquitination of RIP2 is essential for the recruitment of TAK1 (Hasegawa et al. 2008, Hitosumatsu et al. 2008). As observed for toll-like receptor (TLR) signaling, ubiquitination can be removed by the deubiquitinating enzyme A20, thereby dampening NOD1/NOD2-induced NF-kappaB activation. NOD1 and NOD2 both induce K63-linked ubiquitination of RIP2, but NOD2-signaling appears to preferentially utilize the E3 ligase TRAF6, while TRAF2 and TRAF5 were shown to be important for NOD1-mediated signaling. In both cases, activation of NF-kappaB results in the upregulated transcription and production of inflammatory mediators.

UnificationXref8145
type: UnificationXref
id: 3670795
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670795

Evidence1320
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Toll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria, many of which are human or plant pathogens. It is a component of the outer membrane of Gram-negative bacteria and consists of lipid A, a core polysaccharide and an O-polysaccharide of variable length (often more than 50 monosaccharide units). LPS is a potent activator of the innate immune response in humans, causing reactions including fever, headache, nausea, diarrhoea, changes in leukocyte and platelet counts, disseminated intravascular coagulation, multiorgan failure, shock and death. All these reactions are induced by cytokines and other endogenous mediators which are produced after interaction of LPS with the humoral and cellular targets of the host. In macrophages and dendritic cells, LPS-mediated activation of TLR4 triggers the biosynthesis of diverse mediators of inflammation, such as TNF-alpha and IL6, and activates the production of co-stimulatory molecules required for the adaptive immune response. In mononuclear and endothelial cells, LPS also stimulates tissue factor production. These events are desirable for clearing local infections, but when these various mediators and clotting factors are overproduced, they can damage small blood vessels and precipitate shock accompanied by disseminated intravascular coagulation and multiple organ failure.

UnificationXref8146
type: UnificationXref
id: 3670797
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670797

Evidence1321
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12975352
comment: TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial triacylated lipoproteins and peptides, amongst others, triggering up-regulation of nuclear factor-kappaB production and apoptotic cascades. Such cooperation between TLR1 and TLR2 on the cell surface of normal human peripheral blood mononuclear cells, for instance, leads to the activation of pro-inflammatory cytokine secretion (Sandor et al. 2003).

UnificationXref8147
type: UnificationXref
id: REACT_156187
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156187.3

Evidence1322
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14977973
comment: TLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recognizing peptidoglycan wall products from Gram-positive bacteria, as well as Mycobacterial diacylated lipopeptides. In particular, TLR6 appears to participate in discriminating the subtle differences between dipalmitoyl and tripalmitoyl cysteinyl residues (Okusawa et al. 2004).

UnificationXref8148
type: UnificationXref
id: 428819
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428819

UnificationXref8153
type: UnificationXref
id: 3670790
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670790

UnificationXref8152
type: UnificationXref
id: 3670789
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670789

GPCR downstream signaling
type: Pathway
data source: Provenance1
pathway component: REACT 108631.9
pathway component: REACT 99474.9
pathway component: REACT 105270.9
pathway component: G alpha (s) signalling events
evidence: Evidence1179
xref: UnificationXref8711
xref: UnificationXref8710
pathway order: PathwayStep1181
pathway order: PathwayStep1185
pathway order: PathwayStep1183
pathway order: PathwayStep1180
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8155
type: UnificationXref
id: 3670792
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670792

UnificationXref8154
type: UnificationXref
id: 3670791
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670791

UnificationXref8151
type: UnificationXref
id: REACT_20174
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20174.1

UnificationXref8150
type: UnificationXref
id: 428802
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428802

http://identifiers.org/pubmed/17656326
type: PublicationXref
id: 17656326
author: Ardehali, H
author: Burke, MA
db: Pubmed
title: Mitochondrial ATP-binding cassette proteins
source: Transl Res 150:73-80
year: 2007

Evidence1318
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15276183
comment: The first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also been described for TLR4 and TLR2 signaling. MyD88 comprises an N-terminal Death Domain (DD) and a C-terminal TIR, whereas Mal lacks the DD. The TIR homotypic interactions bring adapters into contact with the activated TLRs, whereas the DD modules recruit serine/threonine kinases such as interleukin-1-receptor-associated kinase (IRAK). Recruitment of these protein kinases is accompanied by phosphorylation, which in turn results in the interaction of IRAKs with TNF-receptor-associated factor 6 (TRAF6). The oligomerization of TRAF6 activates TAK1, a member of the MAP3-kinase family, and this leads to the activation of the IkB kinases. These kinases, in turn, phosphorylate IkB, leading to its proteolytic degradation and the translocation of NF-kB to the nucleus. Concomitantly, members of the activator protein-1 (AP-1) transcription factor family, Jun and Fos, are activated, and both AP-1 transcription factors and NF-kB are required for cytokine production, which in turn produces downstream inflammatory effects.

Evidence1319
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/22078883
xref: http://identifiers.org/pubmed/15845500
xref: http://identifiers.org/pubmed/18297073
xref: http://identifiers.org/pubmed/15596121
xref: http://identifiers.org/pubmed/15588429
xref: http://identifiers.org/pubmed/14556004
xref: http://identifiers.org/pubmed/18222170
xref: http://identifiers.org/pubmed/15276183
comment: TLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/interleukin-1-receptor (TIR)-domain-containing adapter protein) and MyD88, which leads to the NFkB activation and the induction of pro-inflammatory cytokines. The second pathway is activated by the adapters TRIF (TIR-domain-containing adapter protein inducing interferon-beta) and TRAM (TRIF-related adapter molecule). The combined use of TRIF and TRAM adapters is specific for TLR4 signaling pathway and leads to the induction of type I interferons and delayed activation of NFkB. The previous model of TLR4 signaling pathway described the simultaneous activation of these two signaling pathways at the plasma membrane, however the later studies suggested that upon activation TLR4 first induces TIRAP-MyD88 signaling at the plasma membrane and is then endocytosed and activates TRAM-TRIF signaling from the early endosome [Kagan JC et al 2008; Tanimura N et al 2008; Zanoni I et al 2011].

Evidence1316
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7700380
xref: PublicationXref2559
xref: http://identifiers.org/pubmed/9799232
xref: http://identifiers.org/pubmed/11130078
xref: http://identifiers.org/pubmed/11470918
xref: http://identifiers.org/pubmed/11564765
xref: http://identifiers.org/pubmed/14751759
comment: CpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated. Therefore, unmethylated CpG DNA may signal the presence of microbial infection. Evidence of CpG recognition by TLR9 was demonstrated both in human and mouse, and this type of signaling requires its internalization into late endosomal/lysosomal compartments. TLR9 has been reported to be able to discern different types of CpG motifs, and therefore that it presumably recognizes CpG DNA directly. It appears that over evolutionary periods, TLR9 molecules expressed by different species have diverged. This has led to differences in the precise sequence motif (CpG dinucleotide plus flanking regions) that optimally stimulate the innate immune system of different animals.

Evidence1317
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18297073
xref: http://identifiers.org/pubmed/16757566
xref: http://identifiers.org/pubmed/18222170
comment: TRIF-related adapter molecule (TRAM or also known as TICAM2) is a sorting adapter which recruits TRIF to activated TLR4. Like TLR4, TRAM was detected both at the plasma membrane and in the endosomal compartment. TRAM was reported to recruit TRIF to the plasma membrane [Tanimuro N et al 2008]. However, TRAM did not induce TRIF-mediated signaling from the cell surface, instead, TRAM endocytosis was required for activation of IRF3 and induction of IFN-beta [Tanimuro N et al 2008; Kagan JC et al 2008]. Although, endocytosis of both TLR4 and TRAM and their association are required to trigger TRIF-mediated signaling, TRAM can target endosomes independently on its interaction with TLR4. TRAM cellular localization is controlled by myristoylation and phosphorylation of its N-terminal bipartite sorting signal motif [Kagan JC et al 2008]. TRAM has been shown to undergo phosphorylation on Ser-16 by protein kinase C epsilon in LPS-treated human THP1 and murine embryonic fibroblasts (MEF) cells [McGettrick AF et al 2006].

Evidence1314
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16497588
xref: http://identifiers.org/pubmed/20237413
xref: http://identifiers.org/pubmed/18652679
xref: http://identifiers.org/pubmed/15276183
comment: Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs.

Evidence1315
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14976262
comment: RNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich ssRNA oligonucleotides derived from human immunodeficiency virus-1 (HIV-1), for example, stimulate dendritic cells (DC) and macrophages to secrete interferon-alpha and proinflammatory, as well as regulatory, cytokines. This has been found to be mediated by TLR7, as well as TLR8. Separate studies showed that imidazoquinoline compounds (e.g. imiquimod and R-848, low-molecular-weight immune response modifiers that can induce the synthesis of interferon-alpha) also exert their effects in a MyD88-dependent fashion independently through TLR7 and 8 (Heil et al. 2004).

Evidence1312
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11489966
xref: http://identifiers.org/pubmed/11323673
xref: PublicationXref2545
comment: TLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modifications that would distinguish it from cellular proteins. However, flagellin is extremely conserved at its amino- and carboxyl-termini, which presumably explains why it was selected as a ligand for innate immune recognition. TLR5 is expressed on epithelial cells as well as on macrophages and dendritic cells. Expression of TLR5 on intestinal epithelium is polarized such that TLR5 is expressed only on the basolateral side of the cell, as pathogenic but not commensal microbes cross the epithelial barrier. This ensures that innate immune responses are confined to pathogenic but not commensal microbes (Paul 2004; Hayashi et al. 2001; Gewirtz et al. 2001).

UnificationXref8138
type: UnificationXref
id: 3670693
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670693

Evidence1313
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18794297
xref: http://identifiers.org/pubmed/22511786
comment: TRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.

UnificationXref8139
type: UnificationXref
id: 3670695
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670695

Evidence1310
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18297073
xref: http://identifiers.org/pubmed/12855817
xref: http://identifiers.org/pubmed/12539043
xref: http://identifiers.org/pubmed/14556004
xref: http://identifiers.org/pubmed/18222170
xref: http://identifiers.org/pubmed/15276183
comment: MyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from TLR3 and TLR4 in a MyD88-independent manner (Yamamoto M et al. 2003a). TRIF is recruited to ligand-stimulated TLR3 or 4 complex via its TIR domain. TLR3 directly binds TRIF (Oshiumi H et al 2003). In contrast, TLR4-mediated signaling pathway requires two adapter molecules, TRAM (TRIF-related adapter molecule or TICAM2) and TRIF. TRAM(TICAM2) is thought to bridge between the activated TLR4 complex and TRIF (Yamamoto M et al. 2003b, Tanimura N et al. 2008, Kagan LC et al. 2008). TRIF recruitment to TLR complex stimulates distinct pathways leading to production of type 1 interferons (IFNs), pro-inflammatory cytokines and induction of programmed cell death.

UnificationXref8136
type: UnificationXref
id: 425977
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425977

Evidence1311
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19627256
xref: http://identifiers.org/pubmed/18202435
xref: http://identifiers.org/pubmed/15733829
xref: http://identifiers.org/pubmed/15031527
comment: Toll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and inflammatory responses of the innate immunity in combating viral infections. Mammalian TLR3 recognizes dsRNA, and that triggers the receptor to induce the activation of NF-kappaB and the production of type I interferons (IFNs). dsRNA-stimulated phosphorylation of two specific TLR3 tyrosine residues (Tyr759 and Tyr858) is essential for initiating TLR3 signaling pathways.

UnificationXref8137
type: UnificationXref
id: REACT_19873
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19873.2

UnificationXref8134
type: UnificationXref
id: 425999
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425999

UnificationXref8135
type: UnificationXref
id: REACT_20336
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20336.1

UnificationXref8144
type: UnificationXref
id: REACT_109067
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_109067.9

UnificationXref8143
type: UnificationXref
id: 3673465
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673465

UnificationXref8142
type: UnificationXref
id: REACT_109449
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_109449.9

UnificationXref8141
type: UnificationXref
id: 3673497
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673497

UnificationXref8140
type: UnificationXref
id: REACT_28080
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28080.10

Evidence1349
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Innate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup

http://identifiers.org/pubmed/15068804
type: PublicationXref
id: 15068804
author: Lima, CD
author: Kiledjian, M
author: Fabrega, C
author: Liu, SW
author: Gu, M
author: Liu, H
db: Pubmed
title: Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity
source: Mol Cell 14:67-80
year: 2004

Evidence1341
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8541526
xref: http://identifiers.org/pubmed/12488490
xref: http://identifiers.org/pubmed/17050193
xref: http://identifiers.org/pubmed/16413920
comment: Phagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phagocytosis is a complex process involving the recognition of invading foreign particles by specific types of phagocytic receptors and the subsequent internalization of the particles. Fc gamma receptors (FCGRs) are among the best studied phagocytic receptors that bind to Fc portion of immunoglobulin G (IgG). Through their antigen binding F(ab) end, antibodies bind to specific antigen while their constant (Fc) region binds to FCGRs on phagocytes. The clustering of FCGRs by IgG antibodies on the phagocyte initiates a variety of signals, which lead, through the reorganisation of actin cytoskeleton and membrane remodelling, to the formation of pseudopod and phagosome. Fc gamma receptors are classified into three classes: FCGRI, FCGRII and FCGRIII. Each class of these FCGRs consists of several individual isoforms. Among all these isoforms FCGRI, FCGRIIA and FCGRIIIA, are able to mediate phagocytosis (Joshi et al. 2006, Garcia Garcia & Rosales 2002, Nimmerjahn & Ravetch 2006).

UnificationXref8167
type: UnificationXref
id: 3670798
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670798

Evidence1342
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15884055
xref: http://identifiers.org/pubmed/17220916
xref: http://identifiers.org/pubmed/17110943
comment: In response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the docking site for the protein tyrosine kinase SYK in myeloid cells and SYK and ZAP70 in NK cells. DAP12-bound SYK autophosphorylates and phosphorylates the scaffolding molecule LAT, recruiting the proximal signaling molecules phosphatidylinositol-3-OH kinase (PI3K), phospholipase-C gamma (PLC-gamma), GADS (GRB2-related adapter downstream of SHC), SLP76 (SH2 domain-containing leukocyte protein of 76 kDa), GRB2:SOS (Growth factor receptor-bound protein 2:Son of sevenless homolog 1) and VAV. All of these intermediate signalling molecules result in the recruitment and activation of kinases AKT, CBL (Casitas B-lineage lymphoma) and ERK (extracellular signal-regulated kinase), and rearrangement of the actin cytoskeleton (actin polymerization) finally leading to cellular activation. PLC-gamma generates the secondary messengers diacylglycerol (DAG) and inositol-1,4,5-trisphosphate (InsP3), leading to activation of protein kinase C (PKC) and calcium mobilization, respectively (Turnbull & Colonna 2007, Klesney-Tait et al. 2006).

UnificationXref8168
type: UnificationXref
id: 3670799
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670799

Evidence1343
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15884055
xref: http://identifiers.org/pubmed/17220916
xref: http://identifiers.org/pubmed/19120482
xref: http://identifiers.org/pubmed/9490415
xref: http://identifiers.org/pubmed/18192027
comment: DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cells. It mediates signalling for multiple cell-surface receptors expressed by these cells, associating with receptor chains through complementary charged transmembrane amino acids that form a salt-bridge in the context of the hydrophobic lipid bilayer (Lanier et al. 1998). DAP12 homodimers associate with a variety of receptors expressed by macrophages, monocytes and myeloid cells including TREM2, Siglec H and SIRP-beta, as well as activating KIR, LY49 and the NKG2C proteins expressed by NK cells. DAP12 is expressed at the cell surface, with most of the protein lying on the cytoplasmic side of the membrane (Turnbull & Colonna 2007, Tessarz & Cerwenka 2008).

UnificationXref8169
type: UnificationXref
id: 3670800
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670800

Evidence1344
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17420272
xref: http://identifiers.org/pubmed/16470226
comment: Formation of the LAT signaling complex leads to activation of MAPK and production of cytokines. The sequence of events that leads from LAT to cytokine production has not been as clearly defined as the sequence that leads to degranulation. However, the pathways that lead to cytokine production require the guanine-nucleotide-exchange factors SOS and VAV that regulate GDPGTP exchange of RAS. After its activation, RAS positively regulates the RAF-dependent pathway that leads to phosphorylation and, in part, activation of the mitogen-activated protein kinases (MAPKs) extracellular-signal-regulated kinase 1 (ERK1) and ERK2 (Gilfillan & Tkaczyk 2006).

Evidence1345
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11772397
xref: http://identifiers.org/pubmed/16252004
xref: http://identifiers.org/pubmed/22798961
comment: T219, T538 at the activation loop, S676 at the turn motif and S695 at the hydrophobic motif are autophosphorylated in cis-maanner. Posphorylation of T538 is critical for kinase activation and it stabilises the open active conformation. Some studies suggest the involvement of PDK1 (3-phosphoinositide-dependent protein kinase 1) and GLK kinases in the phosphorylation T538.

Evidence1346
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16432253
xref: http://identifiers.org/pubmed/17336609
xref: http://identifiers.org/pubmed/17182539
comment: The increase in intracellular Ca+2 in conjunction with DAG also activates PKC and RasGRP, which inturn contributes to cytokine production by mast cells (Kambayashi et al. 2007). Activation of the FCERI engages CARMA1, BCL10 and MALT1 complex to activate NF-kB through PKC-theta (Klemm et al. 2006, Chen et al. 2007). FCERI stimulation leads to phosphorylation, and degradation of IkB which allows the release and nuclear translocation of the NF-kB proteins. Activation of the NF-kB transcription factors then results in the synthesis of several cytokines.

Evidence1347
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17993265
xref: http://identifiers.org/pubmed/17420272
xref: http://identifiers.org/pubmed/15477348
xref: http://identifiers.org/pubmed/17911602
xref: http://identifiers.org/pubmed/20643813
xref: http://identifiers.org/pubmed/15477350
comment: The lipid raft resident adaptor molecules LAT1 and Non-T cell activation linker (NTAL), also known as linker for activation of B cells (LAB)/LAT2 are known participants in the regulation of mast cell calcium responses. Both LAT and NTAL are expressed and phosphorylated following engagement of FCERI on mast cells. NTAL is functionally and topographically different from LAT. There is a considerable debate on the role of NTAL in mast cell. Depending on the circumstances, NTAL appears to have a dual role as positive and negative regulator of MC responses elicited via FCERI. Studies conducted in bone marrow-derived mast cells (BMMCs) of mice lacking NTAL displayed enhanced FCERI-mediated tyrosine phosphorylation of several substrates, calcium response, degranulation, and cytokine production. This indicated that NTAL negatively regulates FCERI-mediated degranulation. However, in mice lacking both LAT and NTAL showed severe block in FCERI-mediated signaling than BMMCs deficient in LAT alone, suggesting that NTAL also shares a redundant function with LAT to play a positive role (Draberova et al. 2007, Orr & McVicar. 2011, Zhu et al. 2004, Volna et al. 2004). The major steps in NTAL mediated Ca+2 influx involves NTAL--> GAB2--> PI3K

Evidence1348
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14630197
xref: http://identifiers.org/pubmed/22112783
xref: http://identifiers.org/pubmed/21799019
xref: http://identifiers.org/pubmed/15099567
xref: http://identifiers.org/pubmed/11449275
xref: http://identifiers.org/pubmed/9354811
comment: Mast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory and immediate allergic reactions. Activation through FCERI-bound antigen-specific IgE causes release of potent inflammatory mediators, such as histamine, proteases, chemotactic factors, cytokines and metabolites of arachidonic acid that act on the vasculature, smooth muscle, connective tissue, mucous glands and inflammatory cells (Borish & Joseph 1992, Amin 2012, Metcalfe et al. 1993). FCERI is a multimeric cell-surface receptor that binds the Fc fragment of IgE with high affinity. On mast cells and basophils FCERI exists as a tetrameric complex consisting of one alpha-chain, one beta-chain, and two disulfide-bonded gamma-chains, and on dendritic cells, Langerhans cells, macrophages, and eosinophils it exists as a trimeric complex with one alpha-chain and two disulfide-bonded gamma-chains (Wu 2011, Kraft & Kinet 2007). FCERI signaling in mast cells includes a network of signaling molecules and adaptor proteins. These molecules coordinate ultimately leading to effects on degranulation, eicosanoid production, and cytokine and chemokine production and cell migration and adhesion, growth and survival. The first step in FCERI signaling is the phosphorylation of the tyrosine residues in the ITAM of both the beta and the gamma subunits of the FCERI by LYN, which is bound to the FCERI beta-chain. The phosphorylated ITAM then recruits the protein tyrosine kinase SYK (spleen tyrosine kinase) which then phosphorylates the adaptor protein LAT. Phosphorylated LAT (linker for activation of T cells) acts as a scaffolding protein and recruits other cytosolic adaptor molecules GRB2 (growth-factor-receptor-bound protein 2), GADS (GRB2-related adaptor protein), SHC (SRC homology 2 (SH2)-domain-containing transforming protein C) and SLP76 (SH2-domain-containing leukocyte protein of 76 kDa), a…

UnificationXref8171
type: UnificationXref
id: REACT_154116
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154116.3

UnificationXref8170
type: UnificationXref
id: 3670802
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670802

UnificationXref8173
type: UnificationXref
id: REACT_159142
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159142.3

UniProt:P34160
type: ProteinReference
xref: UnificationXref928
organism: BioSource1

UnificationXref8172
type: UnificationXref
id: 3673387
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673387

UnificationXref8175
type: UnificationXref
id: REACT_158456
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158456.3

UnificationXref8174
type: UnificationXref
id: 3673388
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673388

Evidence1340
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20400677
xref: PublicationXref2644
xref: http://identifiers.org/pubmed/10224668
comment: Phospholipases play an integral role in phagocytosis by generating essential second messengers. An early step in phagocytic signaling is the association of PIP2 and IP3 with the phagocytic cup. These are formed by the activity of phosphoinositol kinases and phospholipases. PI3K is has been shown to accumulate at phagocytic cups and converts PI (4,5)P2 to PI (3,4,5)P3. These phosphoinositides are capable of binding and increasing the activity of proteins that regulate the actin cytoskeleton. Phospholipases are lipid modifying enzymes that produce lipid mediators such as diacylglycerol (DAG), arachidonic acid (AA) and IP3. Phopsholipases PLA, PLC and PLD have been shown to be involved in antibody (IgG) mediated phagocytosis. The PLC product IP3 stimulates release of calcium from the endoplasmic reticulum. This Ca+2 concentration increase is greatest in the cytoplasm surrounding the phagocytic cup. Calcium is involved in the various stages of phagosome formation, including phagocytic ingestion and phagosome maturation.

UnificationXref8177
type: UnificationXref
id: REACT_5883
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5883.3

UnificationXref8176
type: UnificationXref
id: 158417
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158417

Evidence1338
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15294978
xref: http://identifiers.org/pubmed/16497229
xref: http://identifiers.org/pubmed/10224668
xref: http://identifiers.org/pubmed/9973503
comment: Phospholipase D (PLD) catalyses the hydrolysis of the membrane phospholipid, phosphatidylcholine (PC) to generate choline and metabolically active phosphatidic acid (PA) (Lennartz 1999). Pharmacological inhibition studies show that PLD participates in FCGR-mediated phagocytosis (Kusner et al. 1996). There is an increase in the activity of PLD following the activation of phagocytosis via FCGR (Kusner et al. 1999). Following activation of FCGR, PLD translocates to the plasma membrane at the phagocytic cup and generate PA. This PA can be converted to DAG through the action of phosphatidic acid phosphatase-1 (PAP-1). Thus activation of PLD may be an additional pathway leading to PKC activation. The two isoforms PLD1 and PLD2 are both shown to be essential for the formation of phagosome at different stages. PLD1 is localized on the endosomal/lysosomal compartment and PLD2 is localized at the plasma membrane. PLD2 may be linked to phagosome formation whereas PLD1 may be involved in the focal exocytosis at the plasma membrane and also in the maturation process (Carrotte et al. 2006).

Evidence1339
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10224668
xref: http://identifiers.org/pubmed/17590538
comment: Phosphatidic acid phosphatase (PAP) bound to the plasma membrane catalyzes the dephosphorylation of phosphatidic acid (PA), yielding diacylglycerol (DAG) and inorganic phosphate. In humans, Diacylglycerol pyrophosphate (DPPL1 and DPPL2) perform this reaction.

Evidence1332
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16133426
xref: http://identifiers.org/pubmed/15173891
xref: http://identifiers.org/pubmed/10399917
xref: http://identifiers.org/pubmed/7592757
xref: http://identifiers.org/pubmed/10531386
xref: http://identifiers.org/pubmed/8672512
xref: http://identifiers.org/pubmed/8751438
xref: http://identifiers.org/pubmed/11723063
comment: Advanced Glycosylation End- product-specific Receptor (AGER) also known as Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand membrane receptor belonging to the immunoglobulin superfamily. It is considered to be a Pattern Recognition Receptor (Liliensiek et al. 2004). It recognizes a large variety of modified proteins known as advanced glycation/glycosylation endproducts (AGEs), a heterogenous group of structures that are generated by the Maillard reaction, a consequence of long-term incubation of proteins with glucose (Ikeda et al. 1996). Their accumulation is associated with diabetes, atherosclerosis, renal failure and ageing (Schmidt et al. 1999). The most prevalent class of AGE in vivo are N(6)-carboxymethyllysine (NECML) adducts (Kislinger et al. 1991). In addition to AGEs, AGER is a signal transduction receptor for amyloid-beta peptide (Ab) (Yan et al. 1996), mediating Ab neurotoxicity and promoting Ab influx into the brain. AGER also responds to the proinflammatory S100/calgranulins (Hofmann et al. 1999) and High mobility group protein B1 (HMGB1/Amphoterin/DEF), a protein linked to neurite outgrowth and cellular motility (Hori et al. 1995). The major inflammatory pathway stimulated by AGER activation is NFkappaB. Though the signaling cascade is unclear, several pieces of experimental data suggest that activation of AGER leads to sustained activation and upregulation of NFkappaB, measured as NFkappaB translocation to the nucleus, and increased levels of de novo synthesized NFkappaB (Bierhaus et al. 2001). As this is clearly an indirect effect it is represented here as positive regulation of NFkappaB translocation to the nucleus. AGER can bind ERK1/2 and thereby activate the MAPK and JNK cascades (Bierhaus et al. 2005).

UnificationXref8158
type: UnificationXref
id: CHEBI:17775
db: ChEBI

Evidence1333
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9799231
xref: http://identifiers.org/pubmed/15169870
xref: http://identifiers.org/pubmed/19955216
xref: http://identifiers.org/pubmed/11950933
comment: FCGR mediated phagocytosis requires CDC42 to stimulate actin polymerization, generating the force for phagocytic cup protrusion or pseudopod extension. CDC42 activation is restricted at the advancing edge of the phagocytic cup, where actin is concentrated, and is deactivated at the base of the phagocytic cup (Beemiller et al 2010). The mechanism behind the recruitment and activation of CDC42 during FCGR phagocytosis is unknown. VAV regulates the activation of RAC1 but not CDC42 and the GEF responsible for CDC42 activation during FCGR-mediated phagocytosis remains unidentified (Adam et al 2004, Patel et al 2002).

UnificationXref8159
type: UnificationXref
id: 429056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429056

Evidence1330
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/21245903
xref: http://identifiers.org/pubmed/17875812
xref: http://identifiers.org/pubmed/18446235
xref: http://identifiers.org/pubmed/15967716
xref: http://identifiers.org/pubmed/12830145
xref: http://identifiers.org/pubmed/18928408
comment: The innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of anti-bacterial peptides. The receptors involved recognize conserved molecules present in microbes called pathogen-associated molecular patterns (PAMPs), and/or molecules that are produced as a result of tissue injury, the damage associated molecular pattern molecules (DAMPs). PAMPs are essential to the pathogen and therefore unlikely to vary. Examples are lipopolysaccharide (LPS), peptidoglycans (PGNs) and viral RNA. DAMPs include intracellular proteins, such as heat-shock proteins and extracellular matrix proteins released by tissue injury, such as hyaluronan fragments. Non-protein DAMPs include ATP, uric acid, heparin sulfate and dsDNA. The receptors for these factors are referred to collectively as pathogen- or pattern-recognition receptors (PRRs). The best studied of these are the membrane-associated Toll-like receptor family. Less well studied but more numerous are the intracellular nucleotide-binding domain, leucine rich repeat containing receptors (NLRs) also called nucleotide binding oligomerization domain (NOD)-like receptors, a family with over 20 members in humans and over 30 in mice. These recognise PAMPs/DAMPs from phagocytosed microorganisms or from intracellular infections (Kobayashi et al. 2003, Proell et al. 2008, Wilmanski et al. 2008). Some NLRs are involved in process unrelated to pathogen detection such as tissue homeostasis, apoptosis, graft-versus-host disease and early development (Kufer & Sansonetti 2011). Structurally NLRs can be subdivided into the caspase-recruitment domain (CARD)-containing NLRCs (NODs) and the pyrin domain (PYD)-containing NLRPs (NALPs), plus outliers including ice protease (caspase-1) activating factor (IPAF) (Martinon & Tschopp, 2005). In practical terms, NLRs can be divided into the relatively well characterized NOD1/2 whic…

UnificationXref8156
type: UnificationXref
id: 3670794
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670794

Evidence1331
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15289604
xref: http://identifiers.org/pubmed/10080935
xref: http://identifiers.org/pubmed/8855306
xref: http://identifiers.org/pubmed/8529130
xref: http://identifiers.org/pubmed/1651976
comment: In addition to AGER/RAGE, several other proteins have been identified as AGE-binding proteins. AGE binding proteins p60 and p90 (Yang et al. 1991) were subsequently identified as the Oligosaccharyl transferase 48 kDa subunit (Ost-48) and Glucosidease-2 subunit beta (Li et al. 1996). A third member was identified as Galectin-3 (Vlassara et al. 1995). These 3 proteins have been shown to be present on the plasma membrane of many cell types including vascular endothelium (Stitt et al. 1999). They have been designated AGE-R1, -R2 and -R3. Their suggested function is the removal and degradation of AGEs, but AGER-1 was found to negatively regulate AGER/RAGE (Lu et al. 2004), with kinetics that suggested a more complex interaction than simple competition for the same ligand.

UnificationXref8157
type: UnificationXref
id: REACT_152589
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152589.3

Evidence1336
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11804587
xref: http://identifiers.org/pubmed/11278486
comment: PAK1 needs autophosphorylation for complete activation. PAK1 is autophosphorylated at several sites, but S144 flanking the kinase inhibitor region and T423 within the catalytic domain are the two conserved sites that regulate the catalytic activity (Chong et al. 2001, Parrini et al. 2001).

Evidence1337
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15452139
xref: http://identifiers.org/pubmed/15981459
xref: http://identifiers.org/pubmed/17477841
comment: The actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and CDC42 exert their action through the members of WASP family proteins (WASP/N-WASP/WAVE) and ARP2/3 complex. Actin filaments move from the bottom toward the top of the phagocytic cup during pseudopod extension.

Evidence1334
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10219243
xref: http://identifiers.org/pubmed/10995437
xref: http://identifiers.org/pubmed/10724160
xref: http://identifiers.org/pubmed/15452139
xref: http://identifiers.org/pubmed/19741094
xref: http://identifiers.org/pubmed/9883880
comment: Wiskott-Aldrich syndrome protein (WASP) and Neural-WASP (N-WASP) proteins are scaffolds that transduce signals from cell surface receptors to the activation of the ARP2/3 complex and actin polymerization. WASP and N-WASP possess a central GTPase binding domain (GBD) and an NH2-terminal WASP homology domain 1 (WH1), adjacent to this is a basic region (B) and a C-terminal containing VCA region that contains: a V domain (verprolin homology/WASP homology 2), a C domain (connecting), and an A motif (acidic). The VCA region is responsible for binding to and activating the ARP2/3 complex (Bompard & Caron 2004, Callebaut et al 1998). Under resting conditions, WASP and N-WASP are maintained in an autoinhibition state via interaction of the N-terminal GBD and the C-terminal VCA domains. This prevents access of the ARP2/3 complex to the VCA region. Activated CDC42 binds to the GBD region in N-WASP and this interaction releases the VCA region from autoinhibition enabling binding of the ARP2/3 complex stimulating actin polymerization (Kim et al 2000, Park & Cox 2009). Phosphoinositides (PtdIns(4,5)P2) interact with the basic (B) region in WASP and this interaction is important for activation of the WASP and ARP2/3 complex.(Higgs & Pollard 2000).

Acyl chain remodelling of PI
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction311
pathway component: BiochemicalReaction310
evidence: Evidence504
xref: UnificationXref4216
xref: UnificationXref4217
xref: RelationshipXref408
pathway order: PathwayStep500
pathway order: PathwayStep501
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence1335
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11804587
xref: http://identifiers.org/pubmed/12488490
xref: http://identifiers.org/pubmed/15548136
xref: http://identifiers.org/pubmed/9705280
xref: http://identifiers.org/pubmed/12189515
xref: http://identifiers.org/pubmed/10496324
comment: PAK1, a downstream effector of CDC42 and RAC1, is found localized in phagosomes. Upon activation, PAK1 phosphorylates LIMK, which directly phosphorylates and inactivates cofilin, a protein that mediates depolymerization of actin filaments. Thus, RAC and CDC42 coordinate actin dynamics by inducing actin polymerization via ARP2/3 on one hand, and inhibiting actin depolyerization via LIMK and cofilin on the other (Garcia-Garcia & Rosales 2002). PAK1 exists as homodimer in a trans-inhibited conformation. The kinase inhibitory (KI) domain of one PAK1 molecule binds to the C-terminal catalytic domain of the other and inhibits catalytic activity. GTPases RAC1/CDC42 bind the GBD domain of PAK1 thereby altering the conformation of the KI domain, relieving inhibition of its catalytic domain, and allowing PAK1 autophosphorylation that is required for full kinase activity (Parrini et al. 2002, Zhao & Manser 2005).

http://identifiers.org/pubmed/11470505
type: PublicationXref
id: 11470505
author: Langin, D
author: Reue, K
author: Xia, YR
author: Holm, C
author: Karlsson, M
author: Tornqvist, H
author: Lusis, AJ
db: Pubmed
title: Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene
source: Gene 272:11-8
year: 2001

UnificationXref8162
type: UnificationXref
id: REACT_19454
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19454.1

http://identifiers.org/pubmed/9207791
type: PublicationXref
id: 9207791
author: Bergsagel, PL
author: Nardini, E
author: Ried, T
author: Schröck, E
author: Brents, LA
author: Kuehl, WM
author: Chesi, M
db: Pubmed
title: Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
source: Nat Genet 16:260-4
year: 1997

UnificationXref8161
type: UnificationXref
id: 429078
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429078

UnificationXref8160
type: UnificationXref
id: REACT_19945
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19945.1

UnificationXref8166
type: UnificationXref
id: REACT_19915
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19915.1

UnificationXref8165
type: UnificationXref
id: 429148
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429148

UnificationXref8164
type: UnificationXref
id: REACT_3681
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3681.1

UnificationXref8163
type: UnificationXref
id: 30034
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30034

http://identifiers.org/pubmed/12807903
type: PublicationXref
id: 12807903
author: Nagai, M
author: Sudol, M
author: Navin, NE
author: Komuro, A
db: Pubmed
title: WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
source: J Biol Chem 278:33334-41
year: 2003

Evidence1368
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14517336
comment: In the fourth step of GPI synthesis, an acyl group (typically palmitate) is transferred from acyl CoA to glucosaminyl-PI. Mutagenesis and cloning studies suggest that a single protein, PIG-W, catalyzes this reaction (Murakami et al. 2003).

Evidence1367
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14742432
xref: http://identifiers.org/pubmed/10089216
comment: In the second step of GPI synthesis, N-acetylglucosaminyl-PI is hydrolyzed to yield glucosaminyl-PI and acetate. The phosphatidylinositol (PI) derivatives involved in this reaction are located in the endoplasmic reticulum membrane, as is the PIG-L enzyme that catalyzes it (Sharma et al. 1999; Pottekat and Menon 2004).

Evidence1369
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10069808
xref: http://identifiers.org/pubmed/10574991
xref: http://identifiers.org/pubmed/11159918
comment: In the sixth step of GPI synthesis, a phosphoethanolamine group is transferred from phosphatidylethanolamine onto the first mannose of the GPI precursor. The human protein that catalyzes this reaction was first identified because it could complement a yeast mutant strain defective for GPI synthesis (Gaynor et al. 1999); its specific function in phosphoethanolamine transfer is inferred from functional studies of the homologous mouse protein (Hong et al. 1999). The reaction is annotated here with phosphatidylethanolamine as the donor of the phosphoethanolamine group on the basis of studies in yeast (Imhof et al. 2000).

Evidence1364
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17213197
xref: http://identifiers.org/pubmed/14622290
xref: http://identifiers.org/pubmed/16533814
comment: Cytosolic deoxyhypusine hydroxylase catalyzes the irreversible conversion of peptidyl-deoxyhypusine to peptidyl-hypusine. The only known substrate for this enzyme is the modified lysine at residue 50 of eIF5A (Kang et al. 2007; Kim et al. 2006).

Evidence1363
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16452303
comment: The reaction of EIF5A, spermidine, and NAD+ to form EIF5A(Dhp), 1,3-diaminopropane, and NADH + H+ is reversible in vitro. Under physiological conditions, the reverse reaction is probably minimized by the rapid, irreversible conversion of FIF5A(Dhp) to EIF5A(Hyp).

UnificationXref8189
type: UnificationXref
id: Q03455
db: UniProt

Evidence1366
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: After translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the body. These modifications include the vitamin K-dependent attachment of carboxyl groups to glutamate residues and the conversion of lysine residues to hypusine.

Evidence1365
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16452303
comment: Cytosolic eIF5A undergoes a unique two-step post-translational modification at Lys 50 via deoxyhypusine (Dhp) to hypusine (Hyp). In the first step deoxyhypusine synthase transfers the aminobutyl group of spermidine to the epsilon-amino group of lysine 50, using NAD+ as a cofactor. Hydroxylation of the C2 of the newly added moiety in the second step is catalyzed by deoxyhypusine hydroxylase/monooxygenase with molecular oxygen as the source. The molecular function of eIF5A is unknown, but the protein is required for viability in eukaryotic cells and its normal function requires hypusinylation. eIF5A is the only protein known to undergo hypusinylation (Park 2006).

UnificationXref8190
type: UnificationXref
id: 3670940
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670940

UnificationXref8191
type: UnificationXref
id: 3670942
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670942

UnificationXref8196
type: UnificationXref
id: 3670945
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670945

UniProt:P49167
type: ProteinReference
xref: UnificationXref1486
organism: BioSource1

Evidence1360
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12354605
xref: http://identifiers.org/pubmed/18708324
xref: http://identifiers.org/pubmed/15519848
xref: http://identifiers.org/pubmed/11868281
xref: http://identifiers.org/pubmed/9630229
xref: http://identifiers.org/pubmed/10753735
xref: http://identifiers.org/pubmed/12697815
xref: http://identifiers.org/pubmed/11580265
comment: The eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) plays an essential role in the folding of a subset of proteins prominent among which are the actins and tubulins (reviewed in Altschuler and Willison, 2008). CCT/TRiC is an example of a type II chaperonin, defined (in contrast to type I) as functioning in the absence of a cochaperonin. TriC/CCT is a multisubunit toroidal complex that forms a cylinder containing two back-to-back stacked rings enclosing a cavity where substrate folding occurs in an ATP dependent process (reviewed in Altschuler and Willison, 2008 ). CCT/TriC contains eight paralogous subunits that are conserved throughout eukaryotic organisms (Leroux and Hartl 2000; Archibald et al. 2001; Valpuesta et al. 2002). CCT-mediated folding of non-native substrate protein involves capture through hydrophobic contacts with multiple chaperonin subunits followed by transfer of the protein into the central ring cavity where it folds. Although folding is initiated within this central cavity, only 5%â20% of proteins that are released have partitioned to the native state. The remaining portion is then recaptured by other chaperonin molecules (Cowan and Lewis 2001). This cycling process may be repeated multiple times before a target protein partitions to the native state. In the cell, binding to CCT occurs via presentation of target protein bound to upstream chaperones. During translation, the emerging polypeptide chain may be transferred from the ribosome to CCT via the chaperone Prefoldin (Vainberg et al., 1998) or the Hsp70 chaperone machinery (Melville et al., 2003). While the majority of CCT substrates ultimately partition to the native state as soluble, monomeric proteins, alpha and beta tubulin are unusual in that they require additional cofactors that are required to assemble the tubulin heterodimer (Cowan and Lewis 2001).

UnificationXref8197
type: UnificationXref
id: REACT_130478
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130478.5

UniProt:P16387
type: ProteinReference
xref: UnificationXref4843
organism: BioSource1

Evidence1361
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18395510
xref: http://identifiers.org/pubmed/15519848
xref: http://identifiers.org/pubmed/15459659
comment: Due to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and associate with proteins in their non-native state and facilitate their folding by stabilizing the conformation of productive folding intermediates. Chaperones that take part broadly in de novo protein folding, such as the Hsp70s and the chaperonins, facilitate the folding process through cycles of substrate binding and release regulated by their ATPase activity (see Young et al., 2004; Spiess et al., 2004; Bigotti and Clarke, 2008).

UnificationXref8198
type: UnificationXref
id: 3673511
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673511

Evidence1362
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7673224
xref: http://identifiers.org/pubmed/9188485
xref: http://identifiers.org/pubmed/14622290
xref: http://identifiers.org/pubmed/16452303
comment: Cytosolic deoxyhypusine synthase catalyzes the reaction of EIF5A protein, spermidine, and NAD+ to convert lysine-50 of EIF5A to deoxyhypusine, generating 1,3-diaminopropane and NADH + H+ in the process (Park 2006). Although the reaction is reversible, the reverse reaction is probably minimized under physiological conditions by the rapid, irreversible conversion of EIF5A(Dhp) to EIF5A(Hyp).

UnificationXref8199
type: UnificationXref
id: REACT_138457
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138457.5

UnificationXref8192
type: UnificationXref
id: REACT_87889
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87889.9

UnificationXref8193
type: UnificationXref
id: 216667
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=216667

UnificationXref8194
type: UnificationXref
id: REACT_15863
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15863.2

UnificationXref8195
type: UnificationXref
id: 3670943
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670943

Evidence1359
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9630229
comment: In the case of actin and tubulin folding, and perhaps other substrates, the emerging polypeptide chain is transferred from the ribosome to TRiC via Prefoldin (Vainberg et al., 1998).

Evidence1358
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8104191
xref: http://identifiers.org/pubmed/1351421
xref: http://identifiers.org/pubmed/9630229
comment: Nucleotide-independent transfer of beta-actin from prefoldin to CCT occurs when prefoldin binds to CCT (Vainberg et al., 1998). Following ATP- dependent folding within CCT (Gao et al., 1992), beta-actin is released as a soluble, monomeric protein.

Evidence1357
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9153422
xref: http://identifiers.org/pubmed/7909354
comment: The interaction between CCT and unfolded target proteins is thought to occur when CCT is in its ADP-bound state. ADP is then exchanged for ATP in CCT.

Evidence1356
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9265649
xref: http://identifiers.org/pubmed/1361170
xref: http://identifiers.org/pubmed/11868281
xref: http://identifiers.org/pubmed/8096061
comment: TriC/CCT forms a binary complex with unfolded alpha- or beta-tubulin (Frydman et al., 1992; Gao et al., 1993). The tubulin folding intermediates produced by TriC are unstable (Gao et al., 1993). Five additional protein cofactors (cofactor A-E) are required for the generation of properly folded alpha- and beta-tubulin and for the formation of alpha/beta-tubulin heterodimers (Gao et al., 1993) (Tian et al., 1997, Cowan and Lewis 2001).

http://identifiers.org/pubmed/12657613
type: PublicationXref
id: 12657613
author: Hjelmeland, LM
author: Yoon, H
author: Wang, D
author: Philp, NJ
db: Pubmed
title: Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells
source: Invest Ophthalmol Vis Sci 44:1716-21
year: 2003

http://identifiers.org/pubmed/17698633
type: PublicationXref
id: 17698633
author: Chase, A
author: Grand, FH
author: Cross, NC
db: Pubmed
title: Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome
source: Blood 110:3729-34
year: 2007

Evidence1355
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9153422
xref: http://identifiers.org/pubmed/7909354
comment: The interaction between CCT and unfolded target proteins is thought to occur when CCT is in its ADP-bound state. ADP is then exchanged for ATP in CCT.

Evidence1354
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Transcription by RNA Polymerase I, RNA Polymerase III and transcription from mitochondrial promoters.

Evidence1353
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system.

UnificationXref8179
type: UnificationXref
id: 3670929
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670929

Evidence1352
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2687
xref: PublicationXref2688
xref: PublicationXref2689
xref: http://identifiers.org/pubmed/12613569
comment: Cytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concentrations. Cytokines bind to specific membrane receptors, which then signal the cell via second messengers, to regulate cellular activity.

UnificationXref8178
type: UnificationXref
id: P32798
db: UniProt

UnificationXref8180
type: UnificationXref
id: P20107
db: UniProt

Evidence1350
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6815536
xref: http://identifiers.org/pubmed/12525482
xref: http://identifiers.org/pubmed/3116143
xref: http://identifiers.org/pubmed/17936914
xref: http://identifiers.org/pubmed/19543225
xref: http://identifiers.org/pubmed/18062768
xref: http://identifiers.org/pubmed/3098894
xref: http://identifiers.org/pubmed/1545122
xref: http://identifiers.org/pubmed/6975347
xref: http://identifiers.org/pubmed/18817510
xref: http://identifiers.org/pubmed/3095922
comment: Interleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in vitro and was therefore named 'T cell growth factor' (TCGF). However, the generation of IL-2- and IL-2 receptor-deficient mice revealed that IL-2 also plays a regulatory role in the immune system by suppressing autoimmune responses. Two main mechanisms have been identified that explain this suppressive function: (1) IL-2 sensitizes activated T cells for activation-induced cell death (AICD) and (2) IL-2 is critical for the survival and function of regulatory T cells (Tregs), which possess potent immunosuppressive properties. IL-2 signaling occurs when IL-2 binds to the heterotrimeric high-affinity IL-2 receptor (IL-2R), which consists of alpha, beta and gamma chains. The IL-2R was identified in 1981 via radiolabeled ligand binding (Robb et al. 1981). The IL-2R alpha chain was identified in 1982 (Leonard et al.), the beta chain in 1986/7 (Sharon et al. 1986, Teshigawara et al. 1987) and the IL-2R gamma chain in 1992 (Takeshita et al.). The high affinity of IL-2 binding to the IL-2R is created by a very rapid association rate to the IL-2R alpha chain, combined with a much slower dissociation rate contributed by the combination of the IL-2R beta and gamma chains (Wang & Smith 1987). After antigen stimulation, T cells upregulate the high-affinity IL-2R alpha chain; IL-2R alpha captures IL-2 and this complex then associates with the constitutively expressed IL-2R beta and gamma chains. The IL-2R gamma chain is shared by several other members of the cytokine receptor superfamily including IL-4, IL-7, IL-9, IL-15 and IL-21 receptors, and consequently is often referred to as the Common gamma chain (Gamma-c). The tyrosine kinases Jak1 and Jak3, which are constitutively associated with IL-2R beta and Gamma-c respectively, are activated resulting in phosphorylation of three critica…

UnificationXref8187
type: UnificationXref
id: REACT_16092
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16092.3

Evidence1351
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12445398
xref: http://identifiers.org/pubmed/19302047
comment: Interleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but are now known to be produced by many other cells throughout the body. They have pleiotropic effects on cells which bind them, impacting processes such as tissue growth and repair, hematopoietic homeostasis, and multiple levels of the host defense against pathogens where they are an essential part of the immune system.

UnificationXref8188
type: UnificationXref
id: GO:0030667
db: GENE ONTOLOGY

UnificationXref8185
type: UnificationXref
id: GO:0034774
db: GENE ONTOLOGY

UnificationXref8186
type: UnificationXref
id: 216785
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=216785

UnificationXref8183
type: UnificationXref
id: 3670936
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670936

UnificationXref8184
type: UnificationXref
id: REACT_86417
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86417.9

UnificationXref8181
type: UnificationXref
id: 3670933
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670933

UnificationXref8182
type: UnificationXref
id: 3670934
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670934

Evidence1386
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10359825
comment: Dolichyl-phosphate beta-glucosyltransferase (ALG5) associated with the endoplasmic reticulum (ER) membrane catalyzes the reaction of cytosolic UDP-glucose with dolichyl phosphate exposed on the cytosolic face of the ER membrane to form Dolichyl-P-glucose with its glucose moiety oriented toward the cytosol (Imbach T et al, 1999).

Evidence1385
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: GDP-mannose is the mannose donor for the first 5 mannose addition reactions in the N-glycan precursor synthesis, and also for the synthesis of Dolichyl-phosphate-mannose involved in other mannose transfer reactions. It is synthesized from fructose 6-phosphate and GTP in three steps.

Evidence1388
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18597486
comment: Reactions for the synthesis of the small nucleotide-linked sugar substrates that are used in the synthesis of the N-glycan precursor and in the later steps of glycosylation are annotated here. All these nucleotide-linked sugar donors are synthesized in the cytosol; however, to participate in the later reactions of N-glycan precursor biosynthesis (when the glycan is oriented toward the lumen of the endoplasmic reticulum (ER)), these substrates must be attached to a dolichyl-phosphate molecule and then flipped toward the luminal side of the ER, through a mechanism which is still not known but which involves a different protein than the one that mediates the flipping of the LLO itself (Sanyal S et al, 2008). Two of the genes encoding enzymes involved in these reactions, MPI and PMM2, are known to be associated with Congenital Disorders of Glycosylation (CDG) diseases of type I. Of these, CDG-Ia, associated with defects in PMM2, is the most frequent CDG disease reported.

Evidence1387
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Dolichyl-phosphate-glucose functions as a donor of glucose groups in reactions including three steps of N-glycan precursor biosynthesis. Dolichyl-phosphate-glucose itself is synthesized from UDP-glucose and dolichol phosphate on the cytosolic face of the endoplasmic reticulum membrane, then flipped to the luminal surface of that membrane.

Evidence1389
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12872255
xref: http://identifiers.org/pubmed/9451016
comment: In the first step of N-glycan precursor (LLO) synthesis, N-acetylglucosamine is added, via an alpha-1,3 linkage, to a molecule of dolichyl phosphate, producing N-acetyl-D-glucosaminyl-diphosphodolichol (Eckert V et al, 1998). This reaction is catalyzed by DPAGT1 (ALG7 in yeast), mutations in which are associated with CDG disorder type I-J (Wu X et al, 2003). The dolichyl phosphate acts as an anchor for the LLO, so the following sugar-addition reactions take place on a sugar anchored in the ER membrane.

Evidence1380
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11707391
comment: Cytosolic UAP1 catalyzes the reaction of N-acetyl-D-glucosamine 1-phosphate (GlcNAc1P) and UTP to UDP-N-acetyl-D-glucosamine and pyrophosphate. Structural studies indicate that the active form of the enzyme is a dimer (Peneff C et al, 2001).

Evidence1381
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: UDP-acetylglucosamine acts as a donor for the first two steps of the N-glycan precursor biosynthesis pathway, and is later used as a substrate for further modifications after the precursor has been attached to the protein. It is synthesized from fructose 6-phosphate, glutamine, acetyl-CoA, and UTP in four steps.

Evidence1382
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10980531
xref: http://identifiers.org/pubmed/8307007
comment: Mannose-6-phosphate isomerase (MPI) converts Fructose 6-phosphate to Mannose 6-phosphate (Proudfoot AE et al, 1994). Defects in this gene are associated with congenital disorder of glycosylation type 1B (CDG1B). Oral administration of mannose is an efficient therapy against this defect (Schollen E et al, 2000).

Evidence1383
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9070917
xref: http://identifiers.org/pubmed/9119384
xref: http://identifiers.org/pubmed/9140401
comment: Phosphomannomutase 1 and 2 (PMM1 and PMM2) catalyze the isomerization of Mannose 6-phosphate to Mannose 1-phosphate (Wada Y and Sakamoto M et al, 1997; Matthijs G et al, February 1997). Mutations in the PMM2 gene are one of the causes of Jaeken syndrome. a disease of glycosylation, type CDGIa. (Matthijs G et al, May 1997).

OLI3
type: ProteinReference
name: OLI1
name: Q0130
name: UniProt:P61829 OLI1
name: ATP9
name: PHO2
xref: UnificationXref534
comment: FUNCTION Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.SUBUNIT F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.SIMILARITY Belongs to the ATPase C chain family.
organism: BioSource1

Evidence1384
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/5946626
xref: http://identifiers.org/pubmed/11082198
comment: Mannose 1-phosphate is converted to GDP-Mannose by mannose-1-phosphate guanyltransferase alpha and beta forms (GMPPA/B). This enzyme had originally been characterized from rat and bovine sources (Verachtert H et al, 1966) and more recently from pig (Ning B and Elbein AD, 2000).

Removal of DNA patch containing abasic residue
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction753
evidence: Evidence1218
xref: UnificationXref8845
xref: UnificationXref8844
pathway order: PathwayStep1223
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence1377
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10198162
xref: http://identifiers.org/pubmed/21310273
xref: http://identifiers.org/pubmed/1460020
comment: Glucosamine-fructose 6-phosphate aminotransferase (GFAT) is the first and rate-limiting enzyme in the hexosamine synthesis pathway, and thus formation of hexosamines like N-acetylglucosamine (GlcNAc). This enzyme probably plays a role in limiting the availability of substrates for the N- and O- linked glycosylation of proteins. Two isoforms, GFAT 1 and 2, have been identified (McKnight GL et al, 1992; Oki T et al, 1999). GFAT is required normal functioning of neuromuscular synaptic transmission. Defects in the gene expressing this protein leads to altered muscle fiber morphology and impaired neuromuscular junction development (Senderek et al, 2011).

Evidence1376
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Dolichol is a polyisoprenol lipid comprised of five-carbon isoprene units linked linearly in a head-to-tail fashion. In the N-glycan biosynthesis pathway, dolichyl phosphate is used as an anchor for the N-glycan sugar to the ER membrane, and as an initiation point for the synthesis. Dolichyl phosphate can be obtained either from direct phosphorylation of dolichol or from de-phosphorylation of dolichyl diphosphate, released at the end of the N-glycan biosynthesis pathway.

Evidence1375
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6243292
comment: In the last step of the N-glycan precursor biosynthesis pathway, the mature N-glycan (Glc3Man9GlcNAc2) is removed from the dolichyl diphosphate molecule upon which it has been synthesized, and attached to a nascent protein. In this process, a dolichyl diphosphate molecule is released and once de-phosphorylated by dolichyl diphosphatase 1 (DOLPP1) to obtain dolichyl phosphate, it can be used as a substrate for the synthesis of another N-glycan oligosaccharide (Wedgwood JF and Strominger JL, 1980).

Evidence1374
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17273964
xref: http://identifiers.org/pubmed/12213788
comment: The phosphorylation of a dolichol residue of the ER membrane is a starting step in the N-glycan biosynthesis pathway (Fernandez F et al, 2002). Defects in DOLK are the cause of congenital disorder of glycosylation type 1M (CDG1M), also known as dolichol kinase deficiency (Kranz C et al, 2007).

Evidence1379
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12174217
comment: Cytosolic PGM3 catalyzes the isomerization of N-acetyl-D-glucosamine 6-phosphate (GlcNAc6P) to form N-acetyl-D-glucosamine 1-phosphate (GlcNAc1P) (Pang H et al, 2002).

Evidence1378
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18675810
comment: Cytosolic GNPNAT1 catalyzes the reaction of glucosamine 6-phosphate and acetyl-CoA to form N-acetyl-glucosamine 6-phosphate (GlcNAc6P) and CoA-SH. Structural studies indicate that the active form of the enzyme is a dimer (Wang J et al, 2008).

http://identifiers.org/pubmed/19501527
type: PublicationXref
id: 19501527
author: Cassel, SL
author: Sutterwala, FS
author: Joly, S
db: Pubmed
title: The NLRP3 inflammasome: a sensor of immune danger signals
source: Semin Immunol 21:194-8
year: 2009

Evidence1372
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15632136
xref: http://identifiers.org/pubmed/11102867
xref: http://identifiers.org/pubmed/15208306
comment: Glycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of nine reactions appears to be responsible for the synthesis of the major GPI species involved in membrane protein anchoring. This pathway is shown in the figure. Two additional reactions, not shown, allow the synthesis of variant forms of GPI, one with an additional mannose residue and one with an additional ethanolamine (Tauron et al. 2004; Shishioh et al. 2005). These variant GPI molecules may be used for tissue-specific protein modifications, or may function independently. The steps of GPI synthesis were first identified by isolating large numbers of mutant cell lines that had lost the ability to express GPI anchored proteins on their surfaces. Somatic cell hybrid analyses of these lines allowed the definition of complementation groups corresponding to distinct mutated genes, and cDNAs corresponding to normal forms of these genes were identified on the basis of their abilities to restore normal cell surface protein expression in mutant cells. Co-precipitation experiments with tagged cloned proteins have allowed the identification of additional proteins involved in GPI anchor biosynthesis.

Evidence1373
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Glycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactions appears to be responsible for the synthesis of the major GPI species involved in membrane protein anchoring. As a nascent protein fated to become GPI-anchored moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves it near its carboxy terminus and attaches an acylated GPI moiety. The GPI moiety is deacylated, yielding a protein-GPI conjugate that can be efficiently transported to the Golgi apparatus.

Evidence1370
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15623507
xref: http://identifiers.org/pubmed/15720390
comment: In the seventh reaction of GPI synthesis, a second mannose residue is added to the glycolipid on the lumenal face of the endoplasmic reticulum membrane. PIG-V was identified as the catylyst, or a component of the catalyst, of this reaction, on the basis of its ability to correct the metabolic defects of yeast and mammalian mutant cells arrested at this stage of the GPI synthetic process (Fabre et al. 2005; Kang et al. 2005).

Evidence1371
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8861954
comment: In the eighth reaction of GPI synthesis, a third mannose residue is added, catalyzed by PIG-B (Takahashi et al. 1996).

Evidence1391
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10704531
xref: http://identifiers.org/pubmed/14973782
xref: http://identifiers.org/pubmed/14709599
xref: http://identifiers.org/pubmed/14973778
comment: A mannose is added to the N-glycan precursor via a beta-1,4 linkage. The reaction is catalyzed by ALG1 (Takahashi T et al, 2000). Defects in ALG1 lead to congenital disorder of glycosylation type 1K (CDG1K) (Schwarz M et al, 2004; Kranz C et al, 2004; Grubenmann CE et al, 2004).

Evidence1390
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16100110
comment: A second N-acetylglucosamine is added to the N-glycan precursor via a beta-1,4 linkage. This reaction is catalyzed by the ALG13:ALG14 complex, in which ALG13 functions as the catalyst and ALG14 functions as a membrane anchor which recruits ALG13 to the cytosolic face of ER (Gao XD et al, 2005).

Evidence1393
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12200473
xref: http://identifiers.org/pubmed/15840742
comment: The sixth mannose is added to the N-glycan precursor. This reaction occurs in the ER lumen and uses a different mannose donor (dolichyl phosphate D-mannose) than the previous steps. It has been proposed that ALG3, along with all the mannosyl- and glucosyl transferases in the N-glycan biosynthesis pathway that use dolichyl phosphate D-mannose or dolichyl phosphate D-glucose as donor, derive from duplications of a common ancestral enzyme (Oriol R et al, 2002). Defects in ALG3 are associated with Congenital Disorder of Glycosylation 1D (CDG1D) (Sun L et al, 2005).

Evidence1392
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12684507
comment: A second mannose is added to the N-glycan precursor via an alpha-1,3 linkage. The reaction is catalyzed by the mannosyltransferase ALG2. This is a bifunctional enzyme with both alpha 1,3- and alpha 1,6-mannosyltransferase activities. In humans, only the alpha 1,3 activity used in this reaction has been elucidated (Thiel C et al, 2003). Defects in ALG2 are the cause of CDG1I (Thiel C et al, 2003).

Evidence1395
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11983712
comment: The eighth mannose is added to the N-glycan precursor. This reaction occurs in the ER lumen and uses dolichyl phosphate D-mannose as a mannose donor. Defects in ALG12 are the cause of congenital disorder of glycosylation type 1G (CDG1G) (Chantret I et al, 2002).

UniProt:P34230
type: ProteinReference
xref: UnificationXref3609
organism: BioSource1

Evidence1394
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12030331
xref: http://identifiers.org/pubmed/15945070
xref: http://identifiers.org/pubmed/15148656
xref: http://identifiers.org/pubmed/16859551
comment: The seventh mannose is added to the N-glycan precursor. This reaction occurs in the ER lumen and uses dolichyl phosphate D-mannose as the mannose donor with ALG9 mediating the reaction. Defects in ALG9 are the cause of congenital disorder of glycosylation type 1L (CDG1L) (Frank CG et al, 2004; Weinstein M et al, 2005). For many years ALG9 has been thought to be involved in bipolar affective disorder (Baysal BE et al, 2002), but this hypothesis has been proven wrong (Baysal BE et al, 2006).

UniProt:P34237
type: ProteinReference
xref: UnificationXref2148
organism: BioSource1

http://identifiers.org/pubmed/16100110
type: PublicationXref
id: 16100110
author: Jigami, Y
author: Sato, T
author: Gao, XD
author: Tachikawa, H
author: Dean, N
db: Pubmed
title: Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation
source: J Biol Chem 280:36254-62
year: 2005

Evidence1396
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12030331
xref: http://identifiers.org/pubmed/15945070
xref: http://identifiers.org/pubmed/15148656
xref: http://identifiers.org/pubmed/16859551
comment: The last mannose is added to the N-glycan precursor. This reaction occurs in the ER lumen, uses Dolichyl phosphate D-mannose as the mannose donor, and is catalyzed by ALG9. Defects in ALG9 are the cause of congenital disorder of glycosylation type 1L (CDG1L) (Frank CG et al, 2004; Weinstein M et al, 2005). For many years ALG9 was thought to be involved in bipolar affective disorder (Baysal BE et al, 2002), but this hypothesis has been proven wrong (Baysal BE et al, 2006).

Evidence1397
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16007612
xref: http://identifiers.org/pubmed/10359825
comment: The first glucose is added to the N-glycan precursor, mediated by ALG6. Defects in ALG6 are associated with CDG-Ic disorder (Imbach T et al, 1999; Sun L et al, 2005). The donor is a dolichol-phosphate-glucose (synthesized by ALG5).

http://identifiers.org/pubmed/14567916
type: PublicationXref
id: 14567916
author: DiCorleto, PE
author: Maitra, RK
author: Fox, PL
author: Sampath, P
author: Seshadri, V
author: Mazumder, B
db: Pubmed
title: Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control
source: Cell 115:187-98
year: 2003

Evidence1398
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15235028
xref: PublicationXref2763
comment: The second glucose (supplied from the donor dolichol-phosphate-glucose) is added to the N-glycan precursor, mediated by ALG8 (Schollen E et al, 2004). Defects in ALG8 are the cause of congenital disorder of glycosylation type 1H (CDG1H) (Schollen E et al, 2004; Sun L et al, 2005).

Evidence1399
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20301507
comment: N-linked glycosylation commences with the 14-step synthesis of a dolichol lipid-linked oligosaccharide (LLO) consisting of 14 sugars (2 core GlcNAcs, 9 mannoses and 3 terminal GlcNAcs). This pathway is highly conserved in eukaryotes, and a closely related pathway is found in many eubacteria and Archaea. Mutations in the genes associated with N-glycan precursor synthesis lead to a diverse group of disorders collectively known as Congenital Disorders of Glycosylation (type I and II) (Sparks et al, 1993). The phenotypes of these disorders reflect the important role that N-glycosylation has during development, controlling the folding and the properties of proteins in the secretory pathway, and proteins that mediate cell-to-cell interactions or timing of development.

http://identifiers.org/pubmed/15692562
type: PublicationXref
id: 15692562
author: Sagata, N
db: Pubmed
title: The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs
source: EMBO J 24:1057-67
year: 2005

http://identifiers.org/pubmed/11136719
type: PublicationXref
id: 11136719
author: Kimura, Keiji
author: Cuvier, Olivier
author: Hirano, T
db: Pubmed
title: Chromosome condensation by a human condensin complex in Xenopus egg extracts
source: J. Biol. Chem. 276:5417-20
year: 2001

http://identifiers.org/pubmed/16100120
type: PublicationXref
id: 16100120
author: Lahiri, S
author: Futerman, AH
db: Pubmed
title: LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor
source: J Biol Chem 280:33735-8
year: 2005

http://identifiers.org/pubmed/8887675
type: PublicationXref
id: 8887675
author: Chudzik, DM
author: Hall, BD
author: Bobkova, EV
author: Shaaban, SA
db: Pubmed
title: In vitro analysis of elongation and termination by mutant RNA polymerases with altered termination behavior.
source: Mol Cell Biol 16:6468-76
year: 1996

UniProt:Q12494
type: ProteinReference
xref: UnificationXref3096
organism: BioSource1

http://identifiers.org/pubmed/18690016
type: PublicationXref
id: 18690016
author: Schnetkamp, PP
author: Altimimi, HF
db: Pubmed
title: Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles
source: Channels (Austin) 1:62-9
year: 2007

UniProt:P16370
type: ProteinReference
xref: UnificationXref2315
organism: BioSource1

http://identifiers.org/pubmed/10940339
type: PublicationXref
id: 10940339
author: Laurell, H
author: Holm, C
author: Osterlund, T
author: Contreras, JA
db: Pubmed
title: Molecular mechanisms regulating hormone-sensitive lipase and lipolysis
source: Annu Rev Nutr 20:365-93
year: 2000

UnificationXref8100
type: UnificationXref
id: 1454919
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1454919

http://identifiers.org/pubmed/12562770
type: PublicationXref
id: 12562770
author: Kukar, T
author: Lian, W
author: Wu, D
author: Gu, Y
author: Govindasamy, L
author: McKenna, R
author: Agbandje-McKenna, M
db: Pubmed
title: Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer.
source: J Biol Chem 278:13159-65
year: 2003

http://identifiers.org/pubmed/9153422
type: PublicationXref
id: 9153422
author: Batelier, G
author: Soulié, S
author: Melki, R
author: Williams RC, Jr
db: Pubmed
title: Cytoplasmic chaperonin containing TCP-1: structural and functional characterization
source: Biochemistry 36:5817-26
year: 1997

UnificationXref8110
type: UnificationXref
id: REACT_127834
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127834.5

UnificationXref8111
type: UnificationXref
id: 3673457
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673457

UnificationXref8104
type: UnificationXref
id: 3672092
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672092

UnificationXref8103
type: UnificationXref
id: 3672091
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672091

UnificationXref8102
type: UnificationXref
id: 3672090
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672090

UnificationXref8101
type: UnificationXref
id: REACT_111412
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111412.1

UnificationXref8108
type: UnificationXref
id: 3672096
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672096

UnificationXref8107
type: UnificationXref
id: 3672095
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672095

UnificationXref8106
type: UnificationXref
id: 3672094
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672094

UnificationXref8105
type: UnificationXref
id: 3672093
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672093

UnificationXref8109
type: UnificationXref
id: 3672098
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672098

http://identifiers.org/pubmed/9632701
type: PublicationXref
id: 9632701
author: Rassow, J
author: Kübrich, M
author: Voos, W
author: Pfanner, N
author: Honlinger, Angelika
db: Pubmed
title: The import route of ADP/ATP carrier into mitochondria separates from the general import pathway of cleavable preproteins at the trans side of the outer membrane
source: J Biol Chem 273:16374-81
year: 1998

UnificationXref8120
type: UnificationXref
id: REACT_20087
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20087.2

UnificationXref8121
type: UnificationXref
id: Q04121
db: UniProt

UnificationXref8122
type: UnificationXref
id: 3670696
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670696

UnificationXref8117
type: UnificationXref
id: 83910
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83910

UnificationXref8116
type: UnificationXref
id: CHEBI:29101
db: ChEBI

UnificationXref8119
type: UnificationXref
id: 425971
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425971

UnificationXref8118
type: UnificationXref
id: REACT_3923
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3923.2

UnificationXref8113
type: UnificationXref
id: GO:0031905
db: GENE ONTOLOGY

UnificationXref8112
type: UnificationXref
id: REACT_97867
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97867.9

UnificationXref8115
type: UnificationXref
id: REACT_19509
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19509.1

UnificationXref8114
type: UnificationXref
id: 425978
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425978

http://identifiers.org/pubmed/9914500
type: PublicationXref
id: 9914500
author: di Padova, F
author: Freuler, F
author: Heilker, R
author: Eder, J
author: Pulfer, R
db: Pubmed
title: All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex
source: Eur J Biochem 259:253-61
year: 1999

UnificationXref8132
type: UnificationXref
id: REACT_92820
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92820.9

UnificationXref8133
type: UnificationXref
id: GO:0031906
db: GENE ONTOLOGY

UnificationXref8130
type: UnificationXref
id: 3670699
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670699

UnificationXref8131
type: UnificationXref
id: 3670701
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670701

UnificationXref8129
type: UnificationXref
id: REACT_19769
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19769.2

UnificationXref8128
type: UnificationXref
id: 425958
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425958

UnificationXref8127
type: UnificationXref
id: REACT_19508
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19508.1

UnificationXref8126
type: UnificationXref
id: 425969
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425969

UnificationXref8125
type: UnificationXref
id: GO:0005796
db: GENE ONTOLOGY

UnificationXref8124
type: UnificationXref
id: REACT_91466
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91466.9

UnificationXref8123
type: UnificationXref
id: 3670698
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670698

PublicationXref1391
type: PublicationXref
id: 0079130356
author: Horwich, AL
author: Brusilow, SW
db: ISBN
title: Urea cycle enzymes
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 1909-1963
year: 2001

cobalamin(III)
type: SmallMoleculeReference
name: cob(III)alamin [ChEBI:28911]
name: alpha-(5,6-dimethylbenzimidazolyl)cobamide
name: Cobalamin (III)
name: cobalamin(1+)
name: cob(III)alamin
name: Cbl
xref: UnificationXref5592

http://identifiers.org/pubmed/10987144
type: PublicationXref
id: 10987144
author: Kwon, OS
author: Choi, SY
author: Moon, BJ
author: Lee, HS
db: Pubmed
title: Human pyridoxal kinase: overexpression and properties of the recombinant enzyme
source: Mol Cells 10:452-9
year: 2000

1-acyl-sn-glycero-3-phospho-D-myo-inositol
type: SmallMoleculeReference
name: 1-Acyl-sn-glycero-3-phosphoinositol
name: 1-acyl-sn-glycero-3-phospho-D-myo-inositol [ChEBI:28914]
xref: UnificationXref4205

http://identifiers.org/pubmed/10092594
type: PublicationXref
id: 10092594
author: Jones, JM
author: Gould, SJ
author: Geraghty, MT
author: Nau, K
author: Erdmann, R
db: Pubmed
title: Identification of peroxisomal acyl-CoA thioesterases in yeast and humans
source: J Biol Chem 274:9216-23
year: 1999

http://identifiers.org/pubmed/17335080
type: PublicationXref
id: 17335080
author: Li, HY
author: Zhou, XF
db: Pubmed
title: Roles of glial p75NTR in axonal regeneration
source: J Neurosci Res 85:1601-5
year: 2007

UniProt:Q12446
type: ProteinReference
xref: UnificationXref9275
organism: BioSource1

http://identifiers.org/pubmed/8672512
type: PublicationXref
id: 8672512
author: Horiuchi, S
author: Sano, H
author: Yoshida, M
author: Jinnouchi, Y
author: Higashi, T
author: Ikeda, K
author: Araki, T
author: Ueda, S
db: Pubmed
title: N (epsilon)-(carboxymethyl)lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of the Maillard reaction
source: Biochemistry 35:8075-83
year: 1996

http://identifiers.org/pubmed/19085840
type: PublicationXref
id: 19085840
author: Merezhinskaya, N
author: Fishbein, WN
db: Pubmed
title: Monocarboxylate transporters: past, present, and future
source: Histol Histopathol 24:243-64
year: 2009

http://identifiers.org/pubmed/20576942
type: PublicationXref
id: 20576942
author: Kühl, Michael
author: Rao, Tata Purushothama
db: Pubmed
title: An updated overview on Wnt signaling pathways: a prelude for more
source: Circ. Res. 106:1798-806
year: 2010

2-acyl-sn-glycero-3-phosphoethanolamine [ChEBI:28936]
type: SmallMoleculeReference
name: 2-acyl-sn-glycero-3-phosphoethanolamine
xref: UnificationXref4105

NH4+
type: SmallMoleculeReference
name: NH4+ [ChEBI:28938]
xref: UnificationXref512

UniProt:Q12434
type: ProteinReference
xref: UnificationXref8676
organism: BioSource1

PublicationXref1361
type: PublicationXref
id: 0079130356
author: Thony, B
author: Blau, N
author: Cotton, RG
author: Hyland, K
db: ISBN
title: Disorders of tetrahydrobiopterin and related biogenic amines
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 1725-1776
year: 2001

PublicationXref1362
type: PublicationXref
id: 0079130356
author: Tanguay, RM
author: Mitchell, GA
author: Grompe, M
author: Lambert, M
db: ISBN
title: Hypertyrosinemia
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 1777-1805
year: 2001

PublicationXref1360
type: PublicationXref
id: 0079130356
author: Goodman, SI
author: Frerman, FE
db: ISBN
title: Organic acidemias due to defects in lysine oxidation: 2-ketoadipic acidemia and glutaric acidemia
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 2195-2204
year: 2001

http://identifiers.org/pubmed/10749848
type: PublicationXref
id: 10749848
author: Steinberg, SJ
author: Cuebas, DA
author: Kim, DG
author: Mihalik, SJ
author: Watkins, PA
db: Pubmed
title: The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase
source: J Biol Chem 275:15605-8
year: 2000

PublicationXref1353
type: PublicationXref
id: 0079130356
author: Shih, VE
author: Chuang, DT
db: ISBN
title: Maple syrup urine disease (branched-chain ketoaciduria)
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 1971-2005
year: 2001

PublicationXref1354
type: PublicationXref
id: 0079130356
author: Williams, JC
author: Sweetman, L
db: ISBN
title: Branched chain organic acidurias
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 2125-2163
year: 2001

Asparagine N-linked glycosylation
type: Pathway
data source: Provenance1
pathway component: REACT 127272.5
pathway component: REACT 104983.9
pathway component: REACT 105433.9
evidence: Evidence1410
xref: UnificationXref9763
xref: RelationshipXref1175
xref: UnificationXref9762
pathway order: PathwayStep1405
pathway order: PathwayStep1414
pathway order: PathwayStep1415
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:Q12462
type: ProteinReference
xref: UnificationXref3487
organism: BioSource1

UniProt:Q12469
type: ProteinReference
xref: UnificationXref6917
organism: BioSource1

http://identifiers.org/pubmed/16380219
type: PublicationXref
id: 16380219
author: Dean, NM
author: Koo, S
author: Kang, X
author: Kim, Y
author: White, N
author: Marcusson, EG
author: Perera, RJ
db: Pubmed
title: Identification of novel PPARgamma target genes in primary human adipocytes
source: Gene 369:90-9
year: 2006

PublicationXref1358
type: PublicationXref
id: 0079130356
author: Cox, RP
db: ISBN
title: Errors of lysine metabolism
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 1965-1970
year: 2001

PublicationXref1342
type: PublicationXref
id: 0079130356
author: Phang, JM
author: Hu, CA
author: Valle, D
db: ISBN
title: Disorders of proline and hydroxyproline metabolism
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 1821-1838
year: 2001

UniProt:Q12450
type: ProteinReference
xref: UnificationXref9196
organism: BioSource1

UniProt:Q12452
type: ProteinReference
xref: UnificationXref3779
organism: BioSource1

UniProt:Q12483
type: ProteinReference
xref: UnificationXref1882
organism: BioSource1

UniProt:Q12482
type: ProteinReference
xref: UnificationXref2750
organism: BioSource1

UniProt:Q12480
type: ProteinReference
xref: UnificationXref4977
organism: BioSource1

UniProt:Q12488
type: ProteinReference
xref: UnificationXref1177
organism: BioSource1

M/G1 Transition
type: Pathway
data source: Provenance1
pathway component: DNA Replication Pre-Initiation
evidence: Evidence44
xref: UnificationXref313
xref: UnificationXref312
pathway order: PathwayStep39
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

PublicationXref1337
type: PublicationXref
id: 0079130356
author: Simell, O
author: Valle, D
db: ISBN
title: The hyperornithinemias
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 1857-1895
year: 2001

http://identifiers.org/pubmed/11175906
type: PublicationXref
id: 11175906
author: Burden, A
author: Wu, CK
author: Wang, BC
author: Dailey, HA
author: Rose, JP
author: Sellers, VM
db: Pubmed
title: The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis.
source: Nat Struct Biol 8:156-60
year: 2001

http://identifiers.org/pubmed/12671646
type: PublicationXref
id: 12671646
author: Chao, MV
db: Pubmed
title: Neurotrophins and their receptors: a convergence point for many signalling pathways
source: Nat Rev Neurosci 4:299-309
year: 2003

http://identifiers.org/pubmed/18760361
type: PublicationXref
id: 18760361
author: Maness, PF
author: Schmid, RS
db: Pubmed
title: L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth
source: Curr Opin Neurobiol 18:245-50
year: 2008

SequenceSite1929
type: SequenceSite
position status: EQUAL
sequence position: 664

SequenceSite1928
type: SequenceSite
position status: EQUAL
sequence position: 44

NUDT(1)
type: Complex
data source: Provenance1
member physical entity: NUDT3:Mg2+ (name copied from entity in Homo sapiens)
member physical entity: NUDT10:Mg2+/Mn2+ (name copied from entity in Homo sapiens)
member physical entity: NUDT4:Mg2+/Mn2+ (name copied from entity in Homo sapiens)
xref: UnificationXref3168
cellular location: GO:0005829
display name: DIPP
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3672636

NUDT3:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry819
component stoichiometry: Stoichiometry818
component: SmallMolecule110
component: Protein903
xref: UnificationXref3165
cellular location: GO:0005829
comment: Reactome DB_ID: 3672631

UnificationXref8870
type: UnificationXref
id: Q04049
db: UniProt

UniProt:P39997
type: ProteinReference
xref: UnificationXref4660
organism: BioSource1

IMPA2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry827
component: IMPA2:Mg2+ (name copied from entity in Homo sapiens)
xref: UnificationXref3224
cellular location: GO:0005829
comment: Reactome DB_ID: 3672610

IMPA2:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry826
component stoichiometry: Stoichiometry825
component: SmallMolecule110
component: Protein908
xref: UnificationXref3223
cellular location: GO:0005829
comment: Reactome DB_ID: 3672609

UniProt:P39993
type: ProteinReference
xref: UnificationXref1851
organism: BioSource1

ISYNA1:NAD+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry829
component stoichiometry: Stoichiometry828
component: Protein911
component: SmallMolecule159
xref: UnificationXref3241
cellular location: GO:0005829
comment: Reactome DB_ID: 3672647

UniProt:P39994
type: ProteinReference
xref: UnificationXref3535
organism: BioSource1

NPC1L1:ezetimibe complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry830
component stoichiometry: Stoichiometry831
component: Protein912
component: SmallMolecule209
xref: UnificationXref3271
cellular location: GO:0005886
comment: Reactome DB_ID: 3670165

NUDT10:Mg2+/Mn2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry820
component stoichiometry: Stoichiometry821
component: Protein904
component: SmallMolecule186
xref: UnificationXref3167
cellular location: GO:0005829
comment: Reactome DB_ID: 3672635

IMPA1/2
type: Complex
data source: Provenance1
member physical entity: IMPA1 dimer (name copied from entity in Homo sapiens)
member physical entity: IMPA2 dimer (name copied from entity in Homo sapiens)
xref: UnificationXref3225
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3672611

IMPA1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry824
component: IMPA1:Mg2+ (name copied from entity in Homo sapiens)
xref: UnificationXref3219
cellular location: GO:0005829
comment: Reactome DB_ID: 3672605

UniProt:P39990
type: ProteinReference
xref: UnificationXref2492
organism: BioSource1

IMPA1:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry823
component stoichiometry: Stoichiometry822
component: SmallMolecule110
component: Protein905
xref: UnificationXref3218
cellular location: GO:0005829
comment: Reactome DB_ID: 3672604

UnificationXref8868
type: UnificationXref
id: 3673299
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673299

UnificationXref8869
type: UnificationXref
id: REACT_106453
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106453.9

NUDT4:Mg2+/Mn2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry817
component stoichiometry: Stoichiometry816
component: SmallMolecule186
component: Protein902
xref: UnificationXref3151
cellular location: GO:0005829
comment: Reactome DB_ID: 3672633

http://identifiers.org/pubmed/15189140
type: PublicationXref
id: 15189140
author: de Lange, T
author: Smogorzewska, A
db: Pubmed
title: Regulation of telomerase by telomeric proteins
source: Annu Rev Biochem 73:177-208
year: 2004

http://identifiers.org/pubmed/8682198
type: PublicationXref
id: 8682198
author: Hagerhall, C
author: Hederstedt, L
db: Pubmed
title: A structural model for the membrane-integral domain of succinate: quinone
source: FEBS Lett 389:25-31
year: 1996

UnificationXref8862
type: UnificationXref
id: 3668474
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668474

SequenceSite1920
type: SequenceSite
position status: EQUAL
sequence position: 29

UnificationXref8863
type: UnificationXref
id: REACT_90511
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90511.9

SequenceSite1921
type: SequenceSite
position status: EQUAL
sequence position: 280

UnificationXref8860
type: UnificationXref
id: REACT_3020
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3020.2

SequenceSite1922
type: SequenceSite
position status: EQUAL
sequence position: 30

UnificationXref8861
type: UnificationXref
id: 3668472
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668472

SequenceSite1923
type: SequenceSite
position status: EQUAL
sequence position: 169

UnificationXref8866
type: UnificationXref
id: 3668476
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668476

SequenceSite1924
type: SequenceSite
position status: EQUAL
sequence position: 30

UnificationXref8867
type: UnificationXref
id: REACT_84407
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_84407.9

SequenceSite1925
type: SequenceSite
position status: EQUAL
sequence position: 169

UnificationXref8864
type: UnificationXref
id: 110310
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110310

SequenceSite1926
type: SequenceSite
position status: EQUAL
sequence position: 44

UnificationXref8865
type: UnificationXref
id: REACT_3182
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3182.2

SequenceSite1927
type: SequenceSite
position status: EQUAL
sequence position: 664

((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin-2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry806
component stoichiometry: Stoichiometry805
component: Protein868
component: SmallMolecule155
xref: UnificationXref2936
cellular location: GO:0005829
comment: Reactome DB_ID: 3666607

UniProt:P38759
type: ProteinReference
xref: UnificationXref8737
organism: BioSource1

SequenceSite1939
type: SequenceSite
position status: EQUAL
sequence position: 617

UniProt:P38754
type: ProteinReference
xref: UnificationXref1529
organism: BioSource1

phosphoribosyl pyrophosphate synthetase 1 holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry815
component: Protein888
xref: UnificationXref3061
cellular location: GO:0005829
comment: Reactome DB_ID: 3667534

phosphoribosyl pyrophosphate synthetase holoenzyme
type: Complex
data source: Provenance1
member physical entity: phosphoribosyl pyrophosphate synthetase 1 holoenzyme (name copied from entity in Homo sapiens)
xref: UnificationXref3066
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3667535

PGD dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry813
component: Protein880
xref: UnificationXref3007
cellular location: GO:0005829
comment: Reactome DB_ID: 3666513

http://identifiers.org/pubmed/9536209
type: PublicationXref
id: 9536209
author: Clarke, D
author: Cunningham, SK
author: Fearon, U
author: McKenna, TJ
db: Pubmed
title: A critical review of the origin and control of adrenal androgens
source: Baillieres Clin Obstet Gynaecol 11:229-48
year: 1997

RPE dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry814
component: Protein883
xref: UnificationXref3015
cellular location: GO:0005829
comment: Reactome DB_ID: 3666520

G6PD dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry809
component stoichiometry: Stoichiometry810
component: SmallMolecule7
component: Protein874
xref: UnificationXref2978
cellular location: GO:0005829
comment: Reactome DB_ID: 3666062

G6PD tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry811
component stoichiometry: Stoichiometry812
component: SmallMolecule7
component: Protein874
xref: UnificationXref2979
cellular location: GO:0005829
comment: Reactome DB_ID: 3666063

GALE dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry808
component stoichiometry: Stoichiometry807
component: SmallMolecule159
component: Protein873
xref: UnificationXref2968
cellular location: GO:0005829
comment: Reactome DB_ID: 3666055

G6PD dimer and tetramer
type: Complex
data source: Provenance1
member physical entity: G6PD tetramer (name copied from entity in Homo sapiens)
member physical entity: G6PD dimer (name copied from entity in Homo sapiens)
xref: UnificationXref2980
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3666064

UnificationXref8857
type: UnificationXref
id: 3668471
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668471

UnificationXref8858
type: UnificationXref
id: REACT_108063
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108063.9

UnificationXref8859
type: UnificationXref
id: 110284
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110284

SequenceSite1930
type: SequenceSite
position status: EQUAL
sequence position: 45

((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin-1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry804
component stoichiometry: Stoichiometry803
component: SmallMolecule155
component: Protein865
xref: UnificationXref2932
cellular location: GO:0005829
comment: Reactome DB_ID: 3666601

((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin dimer
type: Complex
data source: Provenance1
member physical entity: ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin-1 dimer (name copied from entity in Homo sapiens)
member physical entity: ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin-2 dimer (name copied from entity in Homo sapiens)
xref: UnificationXref2937
cellular location: GO:0005829
comment: Reactome DB_ID: 3666608
comment: Converted from EntitySet in Reactome

SequenceSite1933
type: SequenceSite
position status: EQUAL
sequence position: 521

UnificationXref8850
type: UnificationXref
id: 3673294
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673294

SequenceSite1934
type: SequenceSite
position status: EQUAL
sequence position: 14

UnificationXref8851
type: UnificationXref
id: REACT_83441
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83441.9

SequenceSite1931
type: SequenceSite
position status: EQUAL
sequence position: 510

UnificationXref8852
type: UnificationXref
id: 109939
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109939

SequenceSite1932
type: SequenceSite
position status: EQUAL
sequence position: 14

UnificationXref8853
type: UnificationXref
id: REACT_2765
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2765.1

SequenceSite1937
type: SequenceSite
position status: EQUAL
sequence position: 255

UnificationXref8854
type: UnificationXref
id: P12689
db: UniProt

SequenceSite1938
type: SequenceSite
position status: EQUAL
sequence position: 34

UnificationXref8855
type: UnificationXref
id: 3668469
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668469

SequenceSite1935
type: SequenceSite
position status: EQUAL
sequence position: 521

UnificationXref8856
type: UnificationXref
id: 3668470
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668470

SequenceSite1936
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref8892
type: UnificationXref
id: MOD:00239
db: MOD

UnificationXref8891
type: UnificationXref
id: REACT_4587
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4587.1

UnificationXref8890
type: UnificationXref
id: 109735
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109735

UniProt:P39976
type: ProteinReference
xref: UnificationXref4935
organism: BioSource1

HSD17B4 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry854
component: Protein948
xref: UnificationXref3563
cellular location: GO:0005782
comment: Reactome DB_ID: 3669333

ABCD1 homodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry855
component: Protein951
xref: UnificationXref3611
cellular location: GO:0005778
comment: Reactome DB_ID: 3670519

HMGCR dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry859
component: Protein938
xref: UnificationXref3647
cellular location: GO:0005789
comment: Reactome DB_ID: 3669264

MVK dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry860
component: Protein953
xref: UnificationXref3655
cellular location: GO:0005829
comment: Reactome DB_ID: 3669277

MVD dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry861
component: Protein954
xref: UnificationXref3666
cellular location: GO:0005829
comment: Reactome DB_ID: 3669299

IDI1 or 2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry862
component stoichiometry: Stoichiometry863
component: SmallMolecule110
component: Protein955
xref: UnificationXref3674
cellular location: GO:0005829
comment: Reactome DB_ID: 3669284

http://identifiers.org/pubmed/8562305
type: PublicationXref
id: 8562305
author: Degerman, E
author: Belfrage, P
author: Manganiello, VC
author: Taira, M
db: Pubmed
title: Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family)
source: Cell Signal 7:445-55
year: 1995

prenyltransferase
type: Complex
data source: Provenance1
member physical entity: holo-GGPS1 hexamer (name copied from entity in Homo sapiens)
member physical entity: holo-FDPS dimer (name copied from entity in Homo sapiens)
xref: UnificationXref3688
cellular location: GO:0005829
comment: Reactome DB_ID: 3669247
comment: Converted from EntitySet in Reactome

holo-FDPS dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry866
component: FDPS:3Mg++ (name copied from entity in Homo sapiens)
xref: UnificationXref3683
cellular location: GO:0005829
comment: Reactome DB_ID: 3669240

FDPS:3Mg++ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry865
component stoichiometry: Stoichiometry864
component: SmallMolecule110
component: Protein956
xref: UnificationXref3682
cellular location: GO:0005829
comment: Reactome DB_ID: 3669239

holo-GGPS1 hexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry869
component: GGPS1:3Mg++ (name copied from entity in Homo sapiens)
xref: UnificationXref3687
cellular location: GO:0005829
comment: Reactome DB_ID: 3669246

http://identifiers.org/pubmed/15189156
type: PublicationXref
id: 15189156
author: Lorsch, JR
author: Kapp, LD
db: Pubmed
title: The molecular mechanics of eukaryotic translation
source: Annu Rev Biochem 73:657-704
year: 2004

UniProt:P38720
type: ProteinReference
xref: UnificationXref3002
organism: BioSource1

SequenceSite1940
type: SequenceSite
position status: EQUAL
sequence position: 12

SequenceSite1941
type: SequenceSite
position status: EQUAL
sequence position: 517

UnificationXref8888
type: UnificationXref
id: P26188
db: UniProt

SequenceSite1946
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref8889
type: UnificationXref
id: 3667746
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667746

SequenceSite1947
type: SequenceSite
position status: EQUAL
sequence position: 484

UnificationXref8886
type: UnificationXref
id: 3673301
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673301

SequenceSite1948
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8887
type: UnificationXref
id: REACT_32474
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32474.10

SequenceSite1949
type: SequenceSite
position status: EQUAL
sequence position: 592

UnificationXref8884
type: UnificationXref
id: 3673300
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673300

SequenceSite1942
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref8885
type: UnificationXref
id: REACT_100450
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100450.9

SequenceSite1943
type: SequenceSite
position status: EQUAL
sequence position: 1010

UnificationXref8882
type: UnificationXref
id: 3673302
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673302

SequenceSite1944
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8883
type: UnificationXref
id: REACT_79222
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79222.9

SequenceSite1945
type: SequenceSite
position status: EQUAL
sequence position: 1338

UniProt:P39988
type: ProteinReference
xref: UnificationXref5559
organism: BioSource1

UnificationXref8881
type: UnificationXref
id: REACT_83674
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83674.9

UnificationXref8880
type: UnificationXref
id: 3668487
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668487

Btn-ACACA:2Mn2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry834
component stoichiometry: Stoichiometry835
component: Protein916
component: SmallMolecule155
xref: UnificationXref3409
cellular location: GO:0005829
comment: Reactome DB_ID: 3668135

ACAT1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry837
component: Protein932
xref: UnificationXref3421
cellular location: GO:0005759
comment: Reactome DB_ID: 3666355

ABCG5:ABCG8 heterodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry833
component stoichiometry: Stoichiometry832
component: Protein913
component: Protein914
xref: UnificationXref3281
cellular location: GO:0005886
comment: Reactome DB_ID: 3670173

NF-Y (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry843
component stoichiometry: Stoichiometry842
component stoichiometry: Stoichiometry844
component: Protein937
component: Protein935
component: Protein936
xref: UnificationXref3462
cellular location: GO:0005654
comment: Reactome DB_ID: 3672275

SREBP1A/1C/2:NF-Y:HMGCS1 gene (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry847
component stoichiometry: Stoichiometry849
component stoichiometry: Stoichiometry848
component: NF-Y (name copied from entity in Homo sapiens)
component: SREBP1A/1C/2 Dimer (name copied from entity in Homo sapiens)
component: PhysicalEntity100
xref: UnificationXref3479
cellular location: GO:0005654
comment: Reactome DB_ID: 3672298

SREBP1A/2:NF-Y:HMGCR gene (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry840
component stoichiometry: Stoichiometry845
component stoichiometry: Stoichiometry841
component: NF-Y (name copied from entity in Homo sapiens)
component: PhysicalEntity98
component: SREBP1A/2 Dimer (name copied from entity in Homo sapiens)
xref: UnificationXref3463
cellular location: GO:0005654
comment: Reactome DB_ID: 3672282

SREBP1A/2 Dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry839
component: PhysicalEntity97
xref: UnificationXref3454
cellular location: GO:0005654
comment: Reactome DB_ID: 3672281

HACL1 holoenzyme monomer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry851
component stoichiometry: Stoichiometry850
component stoichiometry: Stoichiometry852
component: SmallMolecule249
component: Protein947
component: SmallMolecule250
xref: UnificationXref3539
cellular location: GO:0005782
comment: Reactome DB_ID: 3670534

SREBP1A/1C/2 Dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry846
component: PhysicalEntity99
xref: UnificationXref3477
cellular location: GO:0005654
comment: Reactome DB_ID: 3672262

HACL1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry853
component: HACL1 holoenzyme monomer (name copied from entity in Homo sapiens)
xref: UnificationXref3540
cellular location: GO:0005782
comment: Reactome DB_ID: 3670535

SequenceSite1951
type: SequenceSite
position status: EQUAL
sequence position: 592

SequenceSite1952
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1950
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8879
type: UnificationXref
id: REACT_105070
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105070.9

UnificationXref8875
type: UnificationXref
id: 110289
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110289

SequenceSite1959
type: SequenceSite
position status: EQUAL
sequence position: 514

UnificationXref8876
type: UnificationXref
id: REACT_5776
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5776.2

UnificationXref8877
type: UnificationXref
id: 3668483
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668483

SequenceSite1957
type: SequenceSite
position status: EQUAL
sequence position: 514

UnificationXref8878
type: UnificationXref
id: 3668485
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668485

SequenceSite1958
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref8871
type: UnificationXref
id: 3668480
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668480

SequenceSite1955
type: SequenceSite
position status: EQUAL
sequence position: 514

UnificationXref8872
type: UnificationXref
id: 3668481
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668481

SequenceSite1956
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref8873
type: UnificationXref
id: 3668482
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668482

SequenceSite1953
type: SequenceSite
position status: EQUAL
sequence position: 514

UnificationXref8874
type: UnificationXref
id: REACT_78847
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78847.9

SequenceSite1954
type: SequenceSite
position status: EQUAL
sequence position: 2

oligo((1,4)-alpha-glucosyl) glycogenin dimer
type: Complex
data source: Provenance1
member physical entity: oligo((1,4)-alpha-glucosyl) glycogenin 1 dimer (name copied from entity in Homo sapiens)
member physical entity: oligo((1,4)-alpha-glucosyl) glycogenin 2 dimer (name copied from entity in Homo sapiens)
xref: UnificationXref2840
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3666042

GYG2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry765
component stoichiometry: Stoichiometry764
component: Protein821
component: SmallMolecule155
xref: UnificationXref2829
cellular location: GO:0005829
comment: Reactome DB_ID: 3666028

oligo((1,4)-alpha-glucosyl) glycogenin 2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry769
component stoichiometry: Stoichiometry768
component: Protein827
component: SmallMolecule155
xref: UnificationXref2839
cellular location: GO:0005829
comment: Reactome DB_ID: 3666041

oligo((1,4)-alpha-glucosyl) glycogenin 1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry766
component stoichiometry: Stoichiometry767
component: SmallMolecule155
component: Protein824
xref: UnificationXref2835
cellular location: GO:0005829
comment: Reactome DB_ID: 3666035

UnificationXref1598
type: UnificationXref
id: P20459
db: UniProt

UnificationXref1597
type: UnificationXref
id: 3667103
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667103

GYG1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry762
component stoichiometry: Stoichiometry763
component: SmallMolecule155
component: Protein818
xref: UnificationXref2825
cellular location: GO:0005829
comment: Reactome DB_ID: 3666024

glycogenin 1 dimer, glycogenin 2 dimer
type: Complex
data source: Provenance1
member physical entity: GYG2 dimer (name copied from entity in Homo sapiens)
member physical entity: GYG1 dimer (name copied from entity in Homo sapiens)
name: glycogenin dimer
xref: UnificationXref2830
cellular location: GO:0005829
display name: GYG1, GYG2
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3666029

UnificationXref1599
type: UnificationXref
id: 3667099
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667099

UnificationXref1594
type: UnificationXref
id: P32481
db: UniProt

UnificationXref1593
type: UnificationXref
id: REACT_2875
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2875.1

UniProt:P39958
type: ProteinReference
xref: UnificationXref8673
organism: BioSource1

UnificationXref1596
type: UnificationXref
id: P09064
db: UniProt

UnificationXref1595
type: UnificationXref
id: 3667107
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667107

UnificationXref1590
type: UnificationXref
id: 72393
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72393

UniProt:P39954
type: ProteinReference
xref: UnificationXref6222
organism: BioSource1

UnificationXref1592
type: UnificationXref
id: 29438
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438

UnificationXref1591
type: UnificationXref
id: REACT_4829
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4829.1

UnificationXref8823
type: UnificationXref
id: REACT_4879
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4879.1

UnificationXref8822
type: UnificationXref
id: 110225
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110225

UnificationXref8821
type: UnificationXref
id: REACT_104266
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104266.9

UnificationXref8820
type: UnificationXref
id: 3668449
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668449

UnificationXref8827
type: UnificationXref
id: 30140
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30140

8xUGP2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry760
component: Protein815
xref: UnificationXref2815
cellular location: GO:0005829
comment: Reactome DB_ID: 3666012

UnificationXref8826
type: UnificationXref
id: CHEBI:15901
db: ChEBI

UnificationXref8825
type: UnificationXref
id: REACT_87055
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87055.9

UnificationXref8824
type: UnificationXref
id: 3668450
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668450

FBP2 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry755
component stoichiometry: Stoichiometry754
component: SmallMolecule110
component: Protein810
xref: UnificationXref2781
cellular location: GO:0005829
comment: Reactome DB_ID: 3666169

phosphoglucomutase
type: Complex
data source: Provenance1
member physical entity: PGM2:Mg++ (name copied from entity in Homo sapiens)
member physical entity: PGM1:Mg++ (name copied from entity in Homo sapiens)
xref: UnificationXref2802
cellular location: GO:0005829
display name: PGM1, PGM2
comment: Reactome DB_ID: 3666000
comment: Converted from EntitySet in Reactome

PI3K events in ERBB2 signaling
type: Pathway
data source: Provenance1
pathway component: REACT 149929.4
evidence: Evidence1160
xref: UnificationXref8601
xref: UnificationXref8600
pathway order: PathwayStep205
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8829
type: UnificationXref
id: 3668451
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668451

PGM1:Mg++ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry756
component stoichiometry: Stoichiometry757
component: SmallMolecule110
component: Protein811
xref: UnificationXref2798
cellular location: GO:0005829
comment: Reactome DB_ID: 3665994

UnificationXref8828
type: UnificationXref
id: REACT_3731
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3731.1

PGM2:Mg++ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry758
component stoichiometry: Stoichiometry759
component: Protein814
component: SmallMolecule110
xref: UnificationXref2801
cellular location: GO:0005829
comment: Reactome DB_ID: 3665999

FBP1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry752
component stoichiometry: Stoichiometry753
component: SmallMolecule110
component: Protein809
xref: UnificationXref2779
cellular location: GO:0005829
comment: Reactome DB_ID: 3666167

fructose-1,6-bisphosphatase isoforms
type: Complex
data source: Provenance1
member physical entity: FBP1 tetramer (name copied from entity in Homo sapiens)
member physical entity: FBP2 tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref2782
cellular location: GO:0005829
display name: FBP tetramer
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3666170

http://identifiers.org/pubmed/20060739
type: PublicationXref
id: 20060739
author: Sheftel, Alex
author: Stehling, Oliver
author: Lill, R
db: Pubmed
title: Iron-sulfur proteins in health and disease
source: Trends Endocrinol. Metab. 21:302-14
year: 2010

UniProt:P38795
type: ProteinReference
xref: UnificationXref5677
organism: BioSource1

GOT1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry751
component stoichiometry: Stoichiometry750
component: SmallMolecule47
component: Protein807
xref: UnificationXref2760
cellular location: GO:0005829
comment: Reactome DB_ID: 3666282

pyruvate carboxylase holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry747
component stoichiometry: Stoichiometry749
component stoichiometry: Stoichiometry748
component: SmallMolecule143
component: Protein800
component: SmallMolecule144
xref: UnificationXref2733
cellular location: GO:0005759
comment: Reactome DB_ID: 3666215

pyruvate kinase complex, liver and RBC (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry745
component stoichiometry: Stoichiometry746
component stoichiometry: Stoichiometry744
component: SmallMolecule110
component: Protein797
component: SmallMolecule139
xref: UnificationXref2705
cellular location: GO:0005829
comment: Reactome DB_ID: 3666696

UnificationXref1589
type: UnificationXref
id: 3668676
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668676

UnificationXref1588
type: UnificationXref
id: 3667128
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667128

Purine ribonucleoside monophosphate biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction402
pathway component: BiochemicalReaction408
pathway component: BiochemicalReaction407
pathway component: BiochemicalReaction400
pathway component: BiochemicalReaction406
pathway component: BiochemicalReaction403
pathway component: BiochemicalReaction398
pathway component: BiochemicalReaction409
pathway component: BiochemicalReaction404
pathway component: BiochemicalReaction396
pathway component: BiochemicalReaction399
pathway component: BiochemicalReaction397
pathway component: BiochemicalReaction401
pathway component: BiochemicalReaction405
evidence: Evidence642
xref: UnificationXref5123
xref: RelationshipXref576
xref: UnificationXref5124
pathway order: PathwayStep642
pathway order: PathwayStep641
pathway order: PathwayStep643
pathway order: PathwayStep636
pathway order: PathwayStep640
pathway order: PathwayStep632
pathway order: PathwayStep637
pathway order: PathwayStep633
pathway order: PathwayStep634
pathway order: PathwayStep631
pathway order: PathwayStep630
pathway order: PathwayStep639
pathway order: PathwayStep638
pathway order: PathwayStep635
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:P38791
type: ProteinReference
xref: UnificationXref9401
organism: BioSource1

UnificationXref1587
type: UnificationXref
id: 3668675
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668675

UnificationXref1586
type: UnificationXref
id: 3668674
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668674

UnificationXref1585
type: UnificationXref
id: 3668672
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668672

UnificationXref1584
type: UnificationXref
id: REACT_106653
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106653.9

UnificationXref1583
type: UnificationXref
id: 3668682
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668682

UnificationXref1582
type: UnificationXref
id: 3668681
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668681

UniProt:P39965
type: ProteinReference
xref: UnificationXref7486
organism: BioSource1

UnificationXref1581
type: UnificationXref
id: 3667478
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667478

UnificationXref1580
type: UnificationXref
id: 3667447
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667447

UniProt:P38798
type: ProteinReference
xref: UnificationXref7596
organism: BioSource1

UnificationXref8810
type: UnificationXref
id: 110176
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110176

UnificationXref8812
type: UnificationXref
id: 3668441
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668441

UnificationXref8811
type: UnificationXref
id: REACT_3196
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3196.1

UnificationXref8814
type: UnificationXref
id: REACT_83237
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83237.9

UnificationXref8813
type: UnificationXref
id: 3668442
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668442

UnificationXref8816
type: UnificationXref
id: REACT_81890
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81890.9

pyruvate kinase tetramer
type: Complex
data source: Provenance1
member physical entity: pyruvate kinase M1 complex (name copied from entity in Homo sapiens)
member physical entity: pyruvate kinase complex, liver and RBC (name copied from entity in Homo sapiens)
xref: UnificationXref2706
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3666697

UnificationXref8815
type: UnificationXref
id: 3673291
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673291

pyruvate kinase M1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry743
component stoichiometry: Stoichiometry742
component stoichiometry: Stoichiometry741
component: SmallMolecule110
component: Protein794
component: SmallMolecule139
xref: UnificationXref2701
cellular location: GO:0005829
comment: Reactome DB_ID: 3666692

UnificationXref8818
type: UnificationXref
id: 110223
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110223

phosphoglycerate kinase 1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry738
component stoichiometry: Stoichiometry737
component: SmallMolecule110
component: Protein787
xref: UnificationXref2670
cellular location: GO:0005829
comment: Reactome DB_ID: 3666179

UnificationXref8817
type: UnificationXref
id: 3668447
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668447

enolase 1 dimer, (alpha) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry739
component stoichiometry: Stoichiometry740
component: SmallMolecule110
component: Protein788
xref: UnificationXref2690
cellular location: GO:0005829
comment: Reactome DB_ID: 3666203

phosphofructokinase, PL3 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry735
component stoichiometry: Stoichiometry734
component: Protein783
component: Protein780
xref: UnificationXref2634
cellular location: GO:0005829
comment: Reactome DB_ID: 3666146

UnificationXref8819
type: UnificationXref
id: REACT_3342
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3342.1

triosephosphate isomerase dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry736
component: Protein786
xref: UnificationXref2659
cellular location: GO:0005829
comment: Reactome DB_ID: 3666127

PGYM b dimer:AMP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry795
component stoichiometry: Stoichiometry794
component: SmallMolecule131
component: Protein856
xref: UnificationXref2906
cellular location: GO:0005829
comment: Reactome DB_ID: 3666581

PGYM dimer, b form (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry793
component: Protein856
xref: UnificationXref2905
cellular location: GO:0005829
comment: Reactome DB_ID: 3666588

active PYGM and PYGB dimers
type: Complex
data source: Provenance1
member physical entity: PGYM b dimer:AMP (name copied from entity in Homo sapiens)
member physical entity: PGYM dimer a form (name copied from entity in Homo sapiens)
xref: UnificationXref2917
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3666585

limit dextrin-glycogenin-1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry797
component stoichiometry: Stoichiometry798
component: Protein857
component: SmallMolecule155
xref: UnificationXref2914
cellular location: GO:0005829
comment: Reactome DB_ID: 3666575

limit dextrin-glycogenin-2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry801
component stoichiometry: Stoichiometry800
component: SmallMolecule155
component: Protein861
xref: UnificationXref2923
cellular location: GO:0005829
comment: Reactome DB_ID: 3666594

PGYM dimer a form (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry799
component: Protein860
xref: UnificationXref2916
cellular location: GO:0005829
comment: Reactome DB_ID: 3666584

UniProt:P38764
type: ProteinReference
xref: UnificationXref1119
organism: BioSource1

limit dextrin-glycogenin dimer
type: Complex
data source: Provenance1
member physical entity: limit dextrin-glycogenin-2 dimer (name copied from entity in Homo sapiens)
member physical entity: limit dextrin-glycogenin-1 dimer (name copied from entity in Homo sapiens)
xref: UnificationXref2928
cellular location: GO:0005829
comment: Reactome DB_ID: 3666595
comment: Converted from EntitySet in Reactome

PGYL dimer a form (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry802
component: Protein864
xref: UnificationXref2925
cellular location: GO:0005829
comment: Reactome DB_ID: 3666653

TFIIIA
type: ProteinReference
name: UniProt:P39933 PZF1
name: TFC2
name: PZF1
name: P9677.9
name: YPR186C
xref: UnificationXref7004
comment: FUNCTION Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's.MISCELLANEOUS Present with 1380 molecules/cell in log phase SD medium.SIMILARITY Contains 9 C2H2-type zinc fingers.
organism: BioSource1

UniProt:P38767
type: ProteinReference
xref: UnificationXref361
organism: BioSource1

UniProt:P39938
type: ProteinReference
xref: UnificationXref1644
organism: BioSource1

SequenceSite1906
type: SequenceSite
position status: EQUAL
sequence position: 366

SequenceSite1907
type: SequenceSite
position status: EQUAL
sequence position: 35

SequenceSite1908
type: SequenceSite
position status: EQUAL
sequence position: 385

SequenceSite1909
type: SequenceSite
position status: EQUAL
sequence position: 40

UnificationXref8845
type: UnificationXref
id: REACT_98821
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98821.9

SequenceSite1903
type: SequenceSite
position status: EQUAL
sequence position: 28

UnificationXref8844
type: UnificationXref
id: 3673303
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673303

SequenceSite1902
type: SequenceSite
position status: EQUAL
sequence position: 647

UnificationXref8843
type: UnificationXref
id: REACT_105109
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105109.9

SequenceSite1905
type: SequenceSite
position status: EQUAL
sequence position: 28

UniProt:P39929
type: ProteinReference
xref: UnificationXref1893
organism: BioSource1

UnificationXref8842
type: UnificationXref
id: 3668497
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668497

SequenceSite1904
type: SequenceSite
position status: EQUAL
sequence position: 780

UnificationXref8841
type: UnificationXref
id: 3668496
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668496

UnificationXref8840
type: UnificationXref
id: 3668495
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668495

SequenceSite1901
type: SequenceSite
position status: EQUAL
sequence position: 87

SequenceSite1900
type: SequenceSite
position status: EQUAL
sequence position: 259

glycogen-glycogenin-2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry785
component stoichiometry: Stoichiometry786
component: Protein851
component: SmallMolecule155
xref: UnificationXref2888
cellular location: GO:0005829
comment: Reactome DB_ID: 3666659

PGYB dimer b form (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry788
component: Protein855
xref: UnificationXref2898
cellular location: GO:0005829
comment: Reactome DB_ID: 3671227

http://identifiers.org/pubmed/11435397
type: PublicationXref
id: 11435397
author: Allikmets, R
author: Dean, M
author: Rzhetsky, A
db: Pubmed
title: The human ATP-binding cassette (ABC) transporter superfamily
source: Genome Res 11:1156-66
year: 2001

PGYB b dimer:AMP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry790
component stoichiometry: Stoichiometry789
component: SmallMolecule131
component: Protein855
xref: UnificationXref2899
cellular location: GO:0005829
comment: Reactome DB_ID: 3671236

UnificationXref8849
type: UnificationXref
id: REACT_82921
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82921.9

UnificationXref8848
type: UnificationXref
id: 3673305
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673305

UnificationXref8847
type: UnificationXref
id: REACT_93137
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93137.9

UnificationXref8846
type: UnificationXref
id: 3673304
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673304

phosphorylated GYS tetramers
type: Complex
data source: Provenance1
member physical entity: GYS2 tetramer, b form (name copied from entity in Homo sapiens)
member physical entity: GYS1 tetramer, b form (name copied from entity in Homo sapiens)
name: glycogen synthase tetramers, D form
name: GYS1 tetramer, GYS2 tetramer, D forms
xref: UnificationXref2876
cellular location: GO:0005829
display name: GYS tetramers D form
comment: Reactome DB_ID: 3666644
comment: Converted from EntitySet in Reactome

GYS2 tetramer, a form (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry778
component: Protein839
xref: UnificationXref2864
cellular location: GO:0005829
comment: Reactome DB_ID: 3666671

GYS1 tetramer, a form (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry777
component: Protein836
xref: UnificationXref2860
cellular location: GO:0005829
comment: Reactome DB_ID: 3666667

glycogen-glycogenin-1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry783
component stoichiometry: Stoichiometry784
component: SmallMolecule155
component: Protein848
xref: UnificationXref2884
cellular location: GO:0005829
comment: Reactome DB_ID: 3666569

glycogen-glycogenin dimer
type: Complex
data source: Provenance1
member physical entity: glycogen-glycogenin-2 dimer (name copied from entity in Homo sapiens)
member physical entity: glycogen-glycogenin-1 dimer (name copied from entity in Homo sapiens)
xref: UnificationXref2889
cellular location: GO:0005829
comment: Reactome DB_ID: 3666675
comment: Converted from EntitySet in Reactome

GYS2 tetramer, b form (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry782
component: Protein845
xref: UnificationXref2875
cellular location: GO:0005829
comment: Reactome DB_ID: 3666643

GYS1 tetramer, b form (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry781
component: Protein842
xref: UnificationXref2871
cellular location: GO:0005829
comment: Reactome DB_ID: 3666639

SequenceSite1919
type: SequenceSite
position status: EQUAL
sequence position: 333

http://identifiers.org/pubmed/183599
type: PublicationXref
id: 183599
author: Hers, HG
db: Pubmed
title: The control of glycogen metabolism in the liver
source: Annu Rev Biochem 45:167-89
year: 1976

SequenceSite1917
type: SequenceSite
position status: EQUAL
sequence position: 463

SequenceSite1918
type: SequenceSite
position status: EQUAL
sequence position: 28

UniProt:P39939
type: ProteinReference
xref: UnificationXref1642
organism: BioSource1

UnificationXref8832
type: UnificationXref
id: REACT_87883
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87883.9

SequenceSite1916
type: SequenceSite
position status: EQUAL
sequence position: 53

UnificationXref8831
type: UnificationXref
id: 3668452
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668452

SequenceSite1915
type: SequenceSite
position status: EQUAL
sequence position: 1023

UnificationXref8834
type: UnificationXref
id: REACT_85151
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85151.9

SequenceSite1914
type: SequenceSite
position status: EQUAL
sequence position: 41

UnificationXref8833
type: UnificationXref
id: 3673295
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673295

SequenceSite1913
type: SequenceSite
position status: EQUAL
sequence position: 453

SequenceSite1912
type: SequenceSite
position status: EQUAL
sequence position: 68

http://identifiers.org/pubmed/12838422
type: PublicationXref
id: 12838422
author: Young, JD
author: Yao, SY
author: Baldwin, SA
author: Beal, PR
author: King, AE
author: Cass, CE
db: Pubmed
title: The equilibrative nucleoside transporter family, SLC29
source: Pflugers Archpreprint
year: 2003

SequenceSite1911
type: SequenceSite
position status: EQUAL
sequence position: 110

UnificationXref8830
type: UnificationXref
id: REACT_78298
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78298.9

SequenceSite1910
type: SequenceSite
position status: EQUAL
sequence position: 393

poly((1,4)-alpha-glucosyl) glycogenin-2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry774
component stoichiometry: Stoichiometry775
component: SmallMolecule155
component: Protein833
xref: UnificationXref2853
cellular location: GO:0005829
comment: Reactome DB_ID: 3666626

http://identifiers.org/pubmed/12440953
type: PublicationXref
id: 12440953
author: Kruys, V
author: Huez, G
author: Gueydan, C
author: Zhang, T
db: Pubmed
title: AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors
source: Biochem Soc Trans 30:952-8
year: 2002

UnificationXref8839
type: UnificationXref
id: P26793
db: UniProt

glycogen synthase tetramers, I form
type: Complex
data source: Provenance1
member physical entity: GYS1 tetramer, a form (name copied from entity in Homo sapiens)
member physical entity: GYS2 tetramer, a form (name copied from entity in Homo sapiens)
name: GYS1 tetramer, GYS2 tetramer I forms
xref: UnificationXref2865
cellular location: GO:0005829
display name: GYS tetramers I form
comment: Reactome DB_ID: 3666672
comment: Converted from EntitySet in Reactome

poly((1,4)-alpha-glucosyl) glycogenin dimer
type: Complex
data source: Provenance1
member physical entity: poly((1,4)-alpha-glucosyl) glycogenin-1 dimer (name copied from entity in Homo sapiens)
member physical entity: poly((1,4)-alpha-glucosyl) glycogenin-2 dimer (name copied from entity in Homo sapiens)
xref: UnificationXref2854
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3666627

poly((1,4)-alpha-glucosyl) glycogenin-1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry772
component stoichiometry: Stoichiometry773
component: SmallMolecule155
component: Protein830
xref: UnificationXref2849
cellular location: GO:0005829
comment: Reactome DB_ID: 3666620

UnificationXref8836
type: UnificationXref
id: REACT_94342
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94342.9

UnificationXref8835
type: UnificationXref
id: 3673292
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673292

UnificationXref8838
type: UnificationXref
id: REACT_93909
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93909.9

UnificationXref8837
type: UnificationXref
id: 3673293
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673293

UDP-D-galactose [ChEBI:18307]
type: SmallMoleculeReference
name: UDP-D-galactopyranose
name: UDPgalactose
name: UDP-D-galactose
xref: UnificationXref2957

UnificationXref1551
type: UnificationXref
id: 3667429
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667429

UnificationXref1552
type: UnificationXref
id: P10664
db: UniProt

UnificationXref1550
type: UnificationXref
id: P26321
db: UniProt

Deamido-NAD+
type: SmallMoleculeReference
name: Deamino-NAD+
name: Deamino-NAD+ [ChEBI:4340]
xref: UnificationXref5648

phosphatidyl-L-serine
type: SmallMoleculeReference
name: phosphatidyl-L-serines
name: phosphatidyl-L-serine [ChEBI:18303]
xref: UnificationXref7895

UnificationXref1559
type: UnificationXref
id: P0CX41
db: UniProt

UnificationXref1557
type: UnificationXref
id: P0CX42
db: UniProt

UnificationXref1558
type: UnificationXref
id: 3667291
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667291

UnificationXref1555
type: UnificationXref
id: 3667413
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667413

UnificationXref1556
type: UnificationXref
id: 3667414
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667414

http://identifiers.org/pubmed/10744726
type: PublicationXref
id: 10744726
author: Corfas, G
author: Buxbaum, JD
author: Rio, C
author: Peschon, JJ
db: Pubmed
title: Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4
source: J Biol Chem 275:10379-87
year: 2000

UnificationXref1553
type: UnificationXref
id: 3667409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667409

UnificationXref1554
type: UnificationXref
id: P49626
db: UniProt

1-(5'-Phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole
type: SmallMoleculeReference
name: 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide
name: SAICAR
name: 5'-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole
name: 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole [ChEBI:18319]
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
name: 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
xref: UnificationXref5055

UnificationXref1540
type: UnificationXref
id: P26784
db: UniProt

UnificationXref1541
type: UnificationXref
id: 3667208
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667208

NGF signalling via TRKA from the plasma membrane
type: Pathway
data source: Provenance1
pathway component: REACT 83574.9
pathway component: REACT 90182.9
pathway component: REACT 110304.9
evidence: Evidence1153
xref: UnificationXref8587
xref: UnificationXref8586
pathway order: PathwayStep1157
pathway order: PathwayStep1156
pathway order: PathwayStep1159
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1546
type: UnificationXref
id: 3667235
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667235

UnificationXref1547
type: UnificationXref
id: P05740
db: UniProt

UnificationXref1548
type: UnificationXref
id: 3667239
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667239

UnificationXref1549
type: UnificationXref
id: 3667240
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667240

UnificationXref1542
type: UnificationXref
id: P26785
db: UniProt

UnificationXref1543
type: UnificationXref
id: 3667212
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667212

UnificationXref1544
type: UnificationXref
id: 3667213
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667213

UnificationXref1545
type: UnificationXref
id: P46990
db: UniProt

UniProt:Q05521
type: ProteinReference
xref: UnificationXref9306
organism: BioSource1

http://identifiers.org/pubmed/14624363
type: PublicationXref
id: 14624363
author: Bruford, EA
author: Hediger, MA
author: Rolfs, A
author: Romero, MF
author: Takanaga, H
author: Peng, JB
db: Pubmed
title: The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction
source: Pflugers Arch 447:465-8
year: 2004

UnificationXref1570
type: UnificationXref
id: 3667425
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667425

UnificationXref1573
type: UnificationXref
id: P40212
db: UniProt

UnificationXref1574
type: UnificationXref
id: 3667203
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667203

UnificationXref1571
type: UnificationXref
id: Q12690
db: UniProt

UnificationXref1572
type: UnificationXref
id: 3667199
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667199

UnificationXref1577
type: UnificationXref
id: 3667442
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667442

UnificationXref1578
type: UnificationXref
id: P05737
db: UniProt

UnificationXref1575
type: UnificationXref
id: 3667204
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667204

UnificationXref1576
type: UnificationXref
id: Q12213
db: UniProt

UnificationXref1579
type: UnificationXref
id: 3667446
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667446

UniProt:Q05533
type: ProteinReference
xref: UnificationXref3213
organism: BioSource1

UnificationXref1560
type: UnificationXref
id: 3667293
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667293

UnificationXref1561
type: UnificationXref
id: 3667294
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667294

Pyridoxamine phosphate [ChEBI:8670]
type: SmallMoleculeReference
name: Pyridoxamine 5-phosphate
name: Pyridoxamine phosphate
name: Pyridoxamine 5'-phosphate
xref: UnificationXref5568

UnificationXref1562
type: UnificationXref
id: P14120
db: UniProt

UniProt:P16451
type: ProteinReference
xref: UnificationXref4850
organism: BioSource1

UnificationXref1563
type: UnificationXref
id: 3667346
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667346

UnificationXref1564
type: UnificationXref
id: P04650
db: UniProt

UnificationXref1565
type: UnificationXref
id: 3667405
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667405

UnificationXref1566
type: UnificationXref
id: P0CX28
db: UniProt

UnificationXref1567
type: UnificationXref
id: 3667422
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667422

UnificationXref1568
type: UnificationXref
id: P0CX27
db: UniProt

UnificationXref1569
type: UnificationXref
id: 3667424
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667424

SequenceSite1967
type: SequenceSite
position status: EQUAL
sequence position: 456

UniProt:Q05506
type: ProteinReference
xref: UnificationXref7369
organism: BioSource1

SequenceSite1966
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1965
type: SequenceSite
position status: EQUAL
sequence position: 457

SequenceSite1964
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1969
type: SequenceSite
position status: EQUAL
sequence position: 362

SequenceSite1968
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/19644473
type: PublicationXref
id: 19644473
author: Zhao, Jean J
author: Roberts, Thomas M
author: Liu, Pixu
author: Cheng, Hailing
db: Pubmed
title: Targeting the phosphoinositide 3-kinase pathway in cancer
source: Nat Rev Drug Discov 8:627-44
year: 2009

UnificationXref1519
type: UnificationXref
id: 3667246
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667246

SequenceSite1963
type: SequenceSite
position status: EQUAL
sequence position: 693

SequenceSite1962
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref1517
type: UnificationXref
id: 3667341
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667341

SequenceSite1961
type: SequenceSite
position status: EQUAL
sequence position: 514

UnificationXref1518
type: UnificationXref
id: P0CX49
db: UniProt

SequenceSite1960
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref1516
type: UnificationXref
id: 3667177
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667177

UnificationXref1515
type: UnificationXref
id: 3667332
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667332

UnificationXref1514
type: UnificationXref
id: P02406
db: UniProt

UnificationXref1513
type: UnificationXref
id: 3667415
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667415

N,N'-Diacetylchitobiosyldiphosphodolichol [ChEBI:7069]
type: SmallMoleculeReference
name: N,N'-Diacetylchitobiosyldiphosphodolichol
name: Chitobiosyldiphosphodolichol
xref: UnificationXref9589

UnificationXref1512
type: UnificationXref
id: 3667231
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667231

UnificationXref1511
type: UnificationXref
id: 3667230
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667230

UnificationXref1510
type: UnificationXref
id: P05748
db: UniProt

5-phosphoribosylglycinamide [ChEBI:18349]
type: SmallMoleculeReference
name: Glycinamide ribonucleotide
name: GAR
name: 5-phosphoribosylglycinamide
name: N1-(5-Phospho-D-ribosyl)glycinamide
xref: UnificationXref5025

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
type: SmallMoleculeReference
name: ChEBI:18348 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
name: PIP2
xref: UnificationXref2092

UnificationXref8896
type: UnificationXref
id: 3667750
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667750

Evidence4
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20674646
xref: http://identifiers.org/pubmed/21102611
xref: http://identifiers.org/pubmed/12192048
xref: http://identifiers.org/pubmed/11896061
xref: http://identifiers.org/pubmed/14563852
xref: http://identifiers.org/pubmed/16253240
xref: http://identifiers.org/pubmed/19923268
xref: http://identifiers.org/pubmed/16738315
xref: http://identifiers.org/pubmed/20462400
xref: http://identifiers.org/pubmed/16738331
xref: http://identifiers.org/pubmed/17591783
xref: http://identifiers.org/pubmed/16608850
comment: SUMO1, 2, and 3 are initially expressed as propeptides containing extra residues at the C-terminus. (SUMO1 has 4 residues, SUMO2 has 2 residues, and SUMO3 has 11 residues,) SENP1, 2, and 5 are endoproteases that process the precursors to produce the mature peptides (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun et al. 2010, Gareau and Lima 2010). SENP1 processes SUMO1 with greater efficiency than SUMO2 or SUMO3. SENP2 and SENP5 process SUMO2 with greater efficiency than SUMO1 or SUMO3 (Gong and Yeh 2006, Mikolajczyk et al. 2007). SENP1 shuttles between the cytosol and nuceoplasm and is predominantly nuclear (Bailey and O'hare 2004, Kim et al. 2005). SENP2 also shuttles (Itahana et al. 2006) and is mainly located on nucleoplasmic filaments of the nuclear pore complex (Hang and Dasso 2002, Zhang et al. 2002). SENP5 is located mostly in the nucleolus (Di Bacco et al. 2006, Gong and Yeh 2006).

SequenceSite1976
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8895
type: UnificationXref
id: REACT_4869
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4869.1

Evidence3
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12192048
xref: http://identifiers.org/pubmed/11896061
xref: http://identifiers.org/pubmed/14563852
xref: http://identifiers.org/pubmed/15487983
xref: http://identifiers.org/pubmed/16253240
xref: http://identifiers.org/pubmed/16738315
xref: http://identifiers.org/pubmed/16738331
xref: http://identifiers.org/pubmed/17591783
xref: http://identifiers.org/pubmed/16608850
comment: The SUMO3 precursor has 11 extra residues at the C-terminus which can be removed endoproteolytically by SENP1, SENP2, or SENP5 (Zheng and Au, 2005, Gong and Yeh 2006, Mikolajczyk et al. 2007). The order of processing activity is: SENP1 greater than SENP2 greater than SENP5 (Mikolajczyk et al. 2007). Overall, processing of SUMO3 is the lowest of any SUMO (Mikolajczyk et al. 2007). SENP1 and SENP2 shuttle between the nucleus and cytosol and are predominantly nuclear (Bailey and O'Hare 2004, Kim et al. 2005, Zhang et al. 2002, Hang and Dasso 2002, Itahana et al. 2006). SENP5 is located in the nucleolus (Di Bacco et al. 2006, Gong and Yeh 2006).

SequenceSite1975
type: SequenceSite
position status: EQUAL
sequence position: 879

UnificationXref8894
type: UnificationXref
id: 109736
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109736

Evidence2
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12192048
xref: http://identifiers.org/pubmed/11896061
xref: http://identifiers.org/pubmed/14563852
xref: http://identifiers.org/pubmed/15487983
xref: http://identifiers.org/pubmed/16253240
xref: http://identifiers.org/pubmed/16738315
xref: http://identifiers.org/pubmed/16738331
xref: http://identifiers.org/pubmed/17591783
xref: http://identifiers.org/pubmed/16608850
comment: The SUMO2 precursor has 2 extra residues at the C-terminus which can be removed endoproteolytically by SENP1, SENP2, or SENP5 (Zheng and Au, 2005, Gong and Yeh 2006, Mikolajczyk et al. 2007). The order of processing activity is: SENP1 greater than SENP2 greater than SENP5 (Mikolajczyk et al. 2007). SENP2 and SENP5 have highest activity on SUMO2, however the processing activity of SENP1 is higher overall (Mikolajczyk et al. 2007). SENP1 and SENP2 shuttle between the nucleus and cytosol and are predominantly nuclear (Bailey and O'Hare 2004, Kim et al. 2005, Zhang et al. 2002, Hang and Dasso 2002, Itahana et al. 2006). SENP5 is located in the nucleolus (Di Bacco et al. 2006, Gong and Yeh 2006).

SequenceSite1978
type: SequenceSite
position status: EQUAL
sequence position: 1

Disinhibition of SNARE formation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction670
pathway component: BiochemicalReaction669
evidence: Evidence1015
xref: UnificationXref7923
xref: UnificationXref7924
pathway order: PathwayStep1026
pathway order: PathwayStep1025
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8893
type: UnificationXref
id: 3667748
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667748

Evidence1
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12192048
xref: http://identifiers.org/pubmed/11896061
xref: http://identifiers.org/pubmed/14563852
xref: http://identifiers.org/pubmed/15487983
xref: http://identifiers.org/pubmed/16253240
xref: http://identifiers.org/pubmed/16738331
xref: http://identifiers.org/pubmed/17591783
comment: The SUMO1 precursor has 4 extra residues at the C-terminus which can be removed endoproteolytically by either SENP1, SENP2, or SENP5 (Zheng and Au, 2005, Mikolajczyk et al. 2007). The order of processing activity is: SENP1 greater than SENP2 greater than SENP5 (Mikolajczyk et al. 2007). Both SENP1 and SENP2 shuttle between the nucleus and cytoplasmic and both are predominantly nucleoplasmic (Bailey and O'Hare 2004, Kim et al. 2005, Zhang et al. 2002, Hang and Dasso 2002, Itahana et al. 2006).

SequenceSite1977
type: SequenceSite
position status: EQUAL
sequence position: 879

Evidence8
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20674646
xref: http://identifiers.org/pubmed/21102611
xref: http://identifiers.org/pubmed/20164921
xref: http://identifiers.org/pubmed/19923268
comment: The UBA2:SAE1 complex catalyzes the formation of a thioester linkage between the C-terminal glycine of the mature SUMO and a cysteine residue (cysteine-173) in UBA2 (SAE2) (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun et al. 2010, Gareau and Lima 2010). During the process the C-terminal glycine residue of SUMO is reacted with ATP to yield pyrophosphate and a transient intermediate, SUMO adenylate. The SUMO adenylate then reacts with the thiol group of the cysteine residue of UBA2 (Olsen et al. 2010).

UnificationXref8899
type: UnificationXref
id: REACT_29531
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29531.10

Evidence7
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11451954
xref: http://identifiers.org/pubmed/19107418
comment: The UBA2:SAE1 complex catalyzes the formation of a thioester bond between SUMO3 and cysteine-173 of UBA2 (Tatham et al. 2001, Werner et al. 2009). ATP reacts with the C-terminal glycine residue of SUMO3 to yield pyrophosphate and a transient intermediate, SUMO3 adenylate, which then reacts with the thiol group of the cysteine residue on UBA2.

SequenceSite1979
type: SequenceSite
position status: EQUAL
sequence position: 767

UnificationXref8898
type: UnificationXref
id: 3673151
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673151

Evidence6
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11451954
xref: http://identifiers.org/pubmed/19107418
comment: The UBA2:SAE1 complex catalyzes the formation of a thioester bond between SUMO2 and cysteine-173 of UBA2 (Tatham et al. 2001, Werner et al. 2009). ATP reacts with the C-terminal glycine residue of SUMO2 to yield pyrophosphate and a transient intermediate, SUMO2 adenylate, which then reacts with the thiol group of the cysteine residue on UBA2.

UnificationXref8897
type: UnificationXref
id: REACT_89238
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89238.9

Evidence5
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20164921
xref: http://identifiers.org/pubmed/19107418
xref: http://identifiers.org/pubmed/9920803
xref: http://identifiers.org/pubmed/20501649
xref: http://identifiers.org/pubmed/10187858
comment: The UBA2:SAE1 complex catalyzes the formation of a thioester bond between SUMO1 and cysteine-173 of UBA2 (Desterro et al. 1999, Okuma et al. 1999, Werner et al. 2009, Olsen et al. 2010, Wang and Chen 2010). ATP reacts with the C-terminal glycine residue of SUMO1 to yield pyrophosphate and a transient intermediate, SUMO1 adenylate, which then reacts with the thiol group of the cysteine residue on UBA2.

http://identifiers.org/pubmed/19234479
type: PublicationXref
id: 19234479
author: Johnson, E
author: Lewinson, O
author: Rees, DC
db: Pubmed
title: ABC transporters: the power to change
source: Nat Rev Mol Cell Biol 10:218-27
year: 2009

SequenceSite1970
type: SequenceSite
position status: EQUAL
sequence position: 1

Evidence9
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11451954
xref: http://identifiers.org/pubmed/19107418
comment: SUMO3 is transferred from cysteine-173 of UBA2 to cysteine-93 of UBC9 (UBE2I) in a transthiolation reaction (Tatham et al. 2001, Werner et al. 2009).

UnificationXref1506
type: UnificationXref
id: 3667386
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667386

SequenceSite1972
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1507
type: UnificationXref
id: 3667387
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667387

SequenceSite1971
type: SequenceSite
position status: EQUAL
sequence position: 780

UnificationXref1508
type: UnificationXref
id: P54780
db: UniProt

SequenceSite1974
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1509
type: UnificationXref
id: 3667226
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667226

SequenceSite1973
type: SequenceSite
position status: EQUAL
sequence position: 780

UnificationXref1503
type: UnificationXref
id: O14455
db: UniProt

UnificationXref1502
type: UnificationXref
id: 3667378
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667378

PCYT2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry906
component: Protein978
xref: UnificationXref4062
cellular location: GO:0005789
comment: Reactome DB_ID: 3672208

UnificationXref1505
type: UnificationXref
id: P05745
db: UniProt

UnificationXref1504
type: UnificationXref
id: 3667382
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667382

SREBP1A/1C/2:NF-Y:TM7SF2 gene (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry902
component stoichiometry: Stoichiometry901
component stoichiometry: Stoichiometry900
component: NF-Y (name copied from entity in Homo sapiens)
component: SREBP1A/1C/2 Dimer (name copied from entity in Homo sapiens)
component: PhysicalEntity104
xref: UnificationXref3826
cellular location: GO:0005654
comment: Reactome DB_ID: 3672286

SREBP1A/2:SQLE gene (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry899
component stoichiometry: Stoichiometry897
component stoichiometry: Stoichiometry898
component: NF-Y (name copied from entity in Homo sapiens)
component: SREBP1A/2 Dimer (name copied from entity in Homo sapiens)
component: PhysicalEntity103
xref: UnificationXref3821
cellular location: GO:0005654
comment: Reactome DB_ID: 3672294

UnificationXref1501
type: UnificationXref
id: 3667377
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667377

MGLL dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry905
component: Protein977
xref: UnificationXref4047
cellular location: GO:0005789
comment: Reactome DB_ID: 3672118

UnificationXref1500
type: UnificationXref
id: P41056
db: UniProt

CH25H (Fe2+ cofactor) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry904
component stoichiometry: Stoichiometry903
component: SmallMolecule339
component: Protein973
xref: UnificationXref4003
cellular location: GO:0005789
comment: Reactome DB_ID: 3669313

SQLE:FAD (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry874
component stoichiometry: Stoichiometry873
component: Protein959
component: SmallMolecule285
xref: UnificationXref3719
cellular location: GO:0005789
comment: Reactome DB_ID: 3669232

FDFT (Mg2+ cofactor) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry872
component stoichiometry: Stoichiometry871
component: SmallMolecule110
component: Protein958
xref: UnificationXref3701
cellular location: GO:0005789
comment: Reactome DB_ID: 3669291

SREBP1A/2:NF-Y:SC5DL gene (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry894
component stoichiometry: Stoichiometry896
component stoichiometry: Stoichiometry895
component: NF-Y (name copied from entity in Homo sapiens)
component: SREBP1A/2 Dimer (name copied from entity in Homo sapiens)
component: PhysicalEntity102
xref: UnificationXref3816
cellular location: GO:0005654
comment: Reactome DB_ID: 3672302

UniProt:P16474
type: ProteinReference
xref: UnificationXref7943
organism: BioSource1

SREBP1A/1C/2:NF-Y:FDPS gene (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry892
component stoichiometry: Stoichiometry893
component stoichiometry: Stoichiometry891
component: NF-Y (name copied from entity in Homo sapiens)
component: PhysicalEntity101
component: SREBP1A/1C/2 Dimer (name copied from entity in Homo sapiens)
xref: UnificationXref3811
cellular location: GO:0005654
comment: Reactome DB_ID: 3672276

GGPS1:3Mg++ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry867
component stoichiometry: Stoichiometry868
component: SmallMolecule110
component: Protein957
xref: UnificationXref3686
cellular location: GO:0005829
comment: Reactome DB_ID: 3669245

http://identifiers.org/pubmed/10053006
type: PublicationXref
id: 10053006
author: Wasmuth, JJ
author: Thompson, LM
author: Tavormina, PL
author: Jabs, EW
author: Bellus, GA
author: Donoghue, DJ
author: Szabo, J
author: Webster, MK
author: Jiang, W
author: Wilcox, WR
author: Bamshad, MJ
author: Francomano, CA
author: Fraley, AE
author: McIntosh, I
db: Pubmed
title: A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene
source: Am J Hum Genet 64:722-31
year: 1999

SequenceSite1989
type: SequenceSite
position status: EQUAL
sequence position: 527

SequenceSite1988
type: SequenceSite
position status: EQUAL
sequence position: 2

PublicationXref359
type: PublicationXref
id: 16120835
author: Autexier, C
author: Marie-Egyptienne, DT
author: Moriarty, TJ
db: Pubmed
title: Regulation of 5' template usage and incorporation of noncognate nucleotides by human telomerase
source: RNA 11:1448-60
year: 2005

SequenceSite1987
type: SequenceSite
position status: EQUAL
sequence position: 454

SequenceSite1986
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1985
type: SequenceSite
position status: EQUAL
sequence position: 180

SequenceSite1984
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref1539
type: UnificationXref
id: 3667176
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667176

SequenceSite1983
type: SequenceSite
position status: EQUAL
sequence position: 180

SequenceSite1982
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1981
type: SequenceSite
position status: EQUAL
sequence position: 767

SequenceSite1980
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1534
type: UnificationXref
id: 3667255
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667255

4,4-Dimethyl-5alpha-cholesta-8,24-dien-3beta-ol
type: SmallMoleculeReference
name: 14-Demethyllanosterol
name: 14-Demethyllanosterol [ChEBI:755]
xref: UnificationXref3746

UnificationXref1533
type: UnificationXref
id: P0CX23
db: UniProt

UnificationXref1532
type: UnificationXref
id: 3667171
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667171

UnificationXref1531
type: UnificationXref
id: 3667222
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667222

UnificationXref1538
type: UnificationXref
id: P41805
db: UniProt

UnificationXref1537
type: UnificationXref
id: 3667258
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667258

UnificationXref1536
type: UnificationXref
id: 3667257
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667257

UnificationXref1535
type: UnificationXref
id: P0CX24
db: UniProt

Phosphate
type: SmallMoleculeReference
name: Orthophosphate
name: Orthophosphate [ChEBI:18367]
name: Inorganic Phosphate
xref: UnificationXref164

UnificationXref1530
type: UnificationXref
id: 3667221
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667221

http://identifiers.org/pubmed/11257506
type: PublicationXref
id: 11257506
author: Gandour, RD
author: van der Leij, FR
author: Ramsay, RR
db: Pubmed
title: Molecular enzymology of carnitine transfer and transport
source: Biochim Biophys Acta 1546:21-43
year: 2001

Arg-tRNA(Arg)
type: SmallMoleculeReference
name: ChEBI:18366 Arg-tRNA(Arg)
xref: UnificationXref7366

SequenceSite1998
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1997
type: SequenceSite
position status: EQUAL
sequence position: 480

SequenceSite1999
type: SequenceSite
position status: EQUAL
sequence position: 178

UnificationXref1528
type: UnificationXref
id: 3667217
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667217

SequenceSite1994
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1529
type: UnificationXref
id: P38754
db: UniProt

SequenceSite1993
type: SequenceSite
position status: EQUAL
sequence position: 2225

SequenceSite1996
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1995
type: SequenceSite
position status: EQUAL
sequence position: 395

SequenceSite1990
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1992
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1991
type: SequenceSite
position status: EQUAL
sequence position: 527

6-(L-erythro-1,2-Dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
type: SmallMoleculeReference
name: 7,8-dihydroneopterin 3'-triphosphate [ChEBI:18372]
name: 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin
name: 6-(L-erythro-1,2-dihydroxy-3-triphosphooxypropyl)-7,8-dihydropterin
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
name: 7,8-dihydroneopterin 3'-triphosphate
xref: UnificationXref4802

UnificationXref1521
type: UnificationXref
id: 3667248
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667248

UnificationXref1520
type: UnificationXref
id: P0CX50
db: UniProt

UnificationXref1523
type: UnificationXref
id: 3667416
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667416

UnificationXref1522
type: UnificationXref
id: 3667249
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667249

UnificationXref1525
type: UnificationXref
id: 3667359
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667359

UnificationXref1524
type: UnificationXref
id: P38061
db: UniProt

UnificationXref1527
type: UnificationXref
id: P36105
db: UniProt

http://identifiers.org/pubmed/11711427
type: PublicationXref
id: 11711427
author: Wang, X
db: Pubmed
title: The expanding role of mitochondria in apoptosis.
source: Genes Dev 15:2922-33
year: 2001

UnificationXref1526
type: UnificationXref
id: 3667333
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667333

Formylkynurenine [ChEBI:18377]
type: SmallMoleculeReference
name: Formylkynurenine
name: N-Formylkynurenine
xref: UnificationXref5982

Ammonia
type: SmallMoleculeReference
name: NH3 [ChEBI:16134]
name: NH3
xref: UnificationXref2407

Hydrogen sulfide [ChEBI:5787]
type: SmallMoleculeReference
name: H2S
name: Hydrogen-sulfide
name: Hydrogen sulfide
xref: UnificationXref6254

beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol [ChEBI:10408]
type: SmallMoleculeReference
name: Man-beta1->4GlcNAc-beta1->4GlcNAc-PP-Dol
name: beta-1,4-D-Mannosylchitobiosyldiphosphodolichol
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol
xref: UnificationXref9596

http://identifiers.org/pubmed/9278442
type: PublicationXref
id: 9278442
author: Shiba, K
author: Musier-Forsyth, K
author: Stello, T
author: Noda, T
author: Motegi, H
author: Schimmel, P
db: Pubmed
title: Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant
source: J Biol Chem 272:22809-16
year: 1997

http://identifiers.org/pubmed/9278445
type: PublicationXref
id: 9278445
author: Hall, BD
author: Bobkova, EV
db: Pubmed
title: Substrate specificity of the RNase activity of yeast RNA polymerase III.
source: J Biol Chem 272:22832-9
year: 1997

http://identifiers.org/pubmed/14699511
type: PublicationXref
id: 14699511
author: Meier, PJ
author: Kullak-Ublick, GA
author: Stieger, B
db: Pubmed
title: Enterohepatic bile salt transporters in normal physiology and liver disease
source: Gastroenterology 126:322-42
year: 2004

http://identifiers.org/pubmed/8806705
type: PublicationXref
id: 8806705
author: Poulter, CD
author: Hahn, FM
author: Chambers, AF
author: Xuan, JW
db: Pubmed
title: Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization
source: Arch Biochem Biophys 332:30-4
year: 1996

Signaling by FGFR mutants
type: Pathway
data source: Provenance1
pathway component: REACT 140609.5
evidence: Evidence220
xref: UnificationXref2181
xref: UnificationXref2182
pathway order: PathwayStep221
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/14681208
type: PublicationXref
id: 14681208
author: Qin, Y
author: Macara, IG
author: Yi, R
author: Cullen, BR
db: Pubmed
title: Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
source: Genes Dev 17:3011-6
year: 2003

myo-Inositol 4-phosphate [ChEBI:10602]
type: SmallMoleculeReference
name: Inositol 4-phosphate
name: 1D-myo-Inositol 4-phosphate
name: D-myo-Inositol 4-phosphate
name: myo-Inositol 4-phosphate
name: 1D-myo-Inositol 4-monophosphate
xref: UnificationXref3207

Vitamin B1
type: SmallMoleculeReference
name: Antiberiberi factor
name: Thiamine
name: Thiamin [ChEBI:9530]
name: Thiamin
name: Aneurin
xref: UnificationXref5484

5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide
type: SmallMoleculeReference
name: ChEBI:18381 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide
xref: UnificationXref5069

http://identifiers.org/pubmed/7543319
type: PublicationXref
id: 7543319
author: Hameister, H
author: Poustka, A
author: Bachner, D
author: Korn, B
author: Sedlacek, Z
db: Pubmed
title: Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport
source: Hum Mol Genet 4:701-8
year: 1995

http://identifiers.org/pubmed/16650285
type: PublicationXref
id: 16650285
author: Gorelick, DA
author: Agre, P
author: Tsunenari, T
author: Nielsen, S
author: Praetorius, J
db: Pubmed
title: Aquaporin-11: a channel protein lacking apparent transport function expressed in brain
source: BMC Biochem 7:14
year: 2006

UniProt:Q07729
type: ProteinReference
xref: UnificationXref5216
organism: BioSource1

ChEBI:16152 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphates
type: SmallMoleculeReference
name: ChEBI:16152 ChEBI:16152 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphates
xref: UnificationXref9075

http://identifiers.org/pubmed/8752212
type: PublicationXref
id: 8752212
author: Hubbard, SR
author: Schlessinger, J
author: Mohammadi, M
db: Pubmed
title: Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism
source: Cell 86:577-87
year: 1996

Inhibition of HSL
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction586
evidence: Evidence884
xref: UnificationXref6968
xref: UnificationXref6969
pathway order: PathwayStep889
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/8855281
type: PublicationXref
id: 8855281
author: Lu, M
author: Verdijk, MA
author: Smith, BL
author: Agre, P
author: Jung, JS
author: Lee, MD
author: Deen, PM
author: Rijss, JP
author: Merkx, G
db: Pubmed
title: The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain
source: Proc Natl Acad Sci U S A 93:10908-12
year: 1996

2'-deoxyadenosine 5'-diphosphate
type: SmallMoleculeReference
name: 2'-deoxyadenosine 5'-diphosphate [ChEBI:16174]
name: dADP
xref: UnificationXref5344

7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one [ChEBI:2288]
type: SmallMoleculeReference
name: 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one
xref: UnificationXref3837

Evidence1434
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16539657
comment: The SRPR gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

Evidence1433
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16539657
comment: The PPP2R5B gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

Evidence1436
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18664523
comment: The SYVN1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

Evidence1435
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16539657
comment: The SRPRB gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

Evidence1430
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16539657
comment: The GOSR2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

7alpha-Hydroxy-5beta-cholestan-3-one
type: SmallMoleculeReference
name: 7alpha-Hydroxy-5beta-cholestan-3-one [ChEBI:2290]
xref: UnificationXref3846

Evidence1432
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16539657
comment: The KDELR3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

Evidence1431
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16539657
comment: The HYOU1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

Evidence1438
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16539657
comment: The WIPI1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

Evidence1437
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16539657
comment: The Sec31A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

Evidence1439
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16539657
comment: The YIF1A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

Evidence1446
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16987893
xref: http://identifiers.org/pubmed/18786386
xref: http://identifiers.org/pubmed/18775307
xref: http://identifiers.org/pubmed/18802415
comment: At the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 heterodimer transactivates CRY and PER genes by binding E-box elements in their promoters; the CRY and PER proteins then inhibit transactivation by BMAL1:CLOCK/NPAS2. BMAL1:CLOCK/NPAS2 activates transcription of CRY, PER, and several other genes in the morning. Levels of PER and CRY proteins rise during the day and inhibit expression of CRY, PER, and other BMAL1:CLOCK/NPAS2-activated genes in the afternoon and evening. During the night CRY and PER proteins are targeted for degradation by phosphorylation and polyubiquitination, allowing the cycle to commence again in the morning. Transcription of the BMAL1 (ARNTL) gene is controlled by ROR-alpha and REV-ERBA, both of which are targets of BMAL1:CLOCK/NPAS2 in mice and both of which compete for the same element (RORE) in the BMAL1 promoter. ROR-alpha activates transcription of BMAL1; REV-ERBA represses transcription of BMAL1. This mutual control forms a secondary, reinforcing loop of the circadian clock. REV-ERBA shows strong circadian rhythmicity and confers circadian expression on BMAL1. BMAL1 can form heterodimers with either CLOCK or NPAS2, which act redundantly but show different tissue specificity. The BMAL1:CLOCK and BMAL1:NPAS2 heterodimers activate a set of genes that possess E-box elements (consensus CACGTG) in their promoters. This confers circadian expression on the genes. The PER genes (PER1, PER2, PER3) and CRY genes (CRY1, CRY2) are among those activated by BMAL1:CLOCK and BMAL1:NPAS2. PER and CRY mRNA accumulates during the morning and the proteins accumulate during the afternoon. PER and CRY proteins form complexes in the cytosol and these are bound by either CSNK1D or CSNK1E kinases which phosphorylate PER and CRY. The phosphorylated PER:CRY:kinase complex is translocated into the nucleus due to the nuclear localization signal of PER and CRY. Within the nucleus the PER:CRY …

Evidence1445
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9616112
xref: http://identifiers.org/pubmed/12868535
comment: As inferred from mouse, BMAL1:CLOCK and BMAL1:NPAS2 heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et al. 1998, reviewed in Munoz and Baler 2003).

Evidence1444
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18587630
comment: The NOCTURNIN gene is transcribed to yield mRNA and the mRNA is translated to yield protein. The NOCTURNIN gene shows circadian expression because the BMAL1:CLOCK heterodimer binds an E-box element in the NOCTURNIN promoter and activates transcription.

Evidence1443
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Protein metabolism comprises the pathways of translation, post-translational modification and protein folding.

Evidence1442
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16365312
xref: http://identifiers.org/pubmed/15952902
xref: http://identifiers.org/pubmed/18436705
xref: http://identifiers.org/pubmed/18048764
xref: http://identifiers.org/pubmed/18038217
comment: The Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER during times of unusually high secretion activity. Analysis of mutants with altered UPR, however, shows that the UPR is also required for normal development and function of secretory cells. One level at which the URP operates is transcriptional and translational regulation: mobilization of ATF6 and IRE1 leads to increased transcription of genes encoding chaperones, and mobilization of PERK (pancreatic eIF2alpha kinase) leads to phosphorylation of the translation initiation factor eIF2alpha and global down-regulation of protein synthesis. These three regulatory pathways are annotated here.

Evidence1441
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18436705
xref: http://identifiers.org/pubmed/18048764
xref: http://identifiers.org/pubmed/18038217
comment: IRE1-alpha is a single-pass transmembrane protein that resides in the endoplasmic reticulum (ER) membrane. The C-terminus of IRE1-alpha is located in the cytosol; the N-terminus is located in the ER lumen. In unstressed cells IRE1-alpha exists in an inactive heterodimeric complex with BiP such that BiP in the ER lumen binds the N-terminal region of IRE1-alpha. Upon accumulation of unfolded proteins in the ER, BiP binds the unfolded protein and the IRE1-alpha:BiP complex dissociates. The dissociated IRE1-alpha then forms homodimers. Initially the luminal N-terminal regions pair. This is followed by trans-autophosphorylation of IRE1-alpha at Ser724 in the cytosolic C-terminal region. The phosphorylation causes a conformational change that allows the dimer to bind ADP, causing a further conformational change to yield back-to-back pairing of the cytosolic C-terminal regions of IRE1-alpha. The fully paired IRE1-alpha homodimer has endoribonuclease activity and cleaves the mRNA encoding Xbp-1. A 26 residue polyribonucleotide is released and the 5' and 3' fragments of the original Xbp-1 mRNA are rejoined. The spliced Xbp-1 message encodes Xbp-1 (S), a potent activator of transcription. Xbp-1 (S) together with the ubiquitous transcription factor NF-Y bind the ER Stress Responsive Element (ERSE) in a number of genes encoding chaperones. Recent data suggest that the IRE1-alpha homodimer can also cleave specific subsets of mRNAs, including the insulin (INS) mRNA in pancreatic beta cells.

Evidence1440
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16461360
xref: http://identifiers.org/pubmed/17612490
xref: http://identifiers.org/pubmed/16539657
xref: http://identifiers.org/pubmed/14559994
xref: http://identifiers.org/pubmed/18664523
comment: Xbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotrimer, binds the CCAAT portion of the ERSE and together the IRE1-alpha: NF-Y complex activates transcription of a set of chaperone genes including DNAJB9, EDEM, RAMP4, p58IPK, and others. This results in an increase in protein folding activity in the ER.

CIA1
type: ProteinReference
name: YDR267C
name: UniProt:Q05583 CIA1
xref: UnificationXref6659
comment: FUNCTION Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.SUBUNIT Interacts with NAR1.MISCELLANEOUS Present with 5640 molecules/cell in log phase SD medium.SIMILARITY Belongs to the WD repeat CIA1 family.SIMILARITY Contains 7 WD repeats.
organism: BioSource1

http://identifiers.org/pubmed/15231747
type: PublicationXref
id: 15231747
author: Lehner, B
author: Sanderson, CM
db: Pubmed
title: A protein interaction framework for human mRNA degradation
source: Genome Res 14:1315-23
year: 2004

(9Z)-octadec-9-enoic acid
type: SmallMoleculeReference
name: Oleic acid
name: ChEBI:16196 Oleic acid
xref: UnificationXref8322

dGMP
type: SmallMoleculeReference
name: Deoxyguanylic acid
name: 2'-Deoxyguanosine 5'-phosphate
name: 2'-Deoxyguanosine 5'-monophosphate
name: dGMP [ChEBI:16192]
name: Deoxyguanosine monophosphate
xref: UnificationXref5378

http://identifiers.org/pubmed/5441548
type: PublicationXref
id: 5441548
author: Salen, G
author: Grundy, SM
author: Ahrens EH, Jr
db: Pubmed
title: Metabolism of beta-sitosterol in man
source: J Clin Invest 49:952-67
year: 1970

Urea [ChEBI:16199]
type: SmallMoleculeReference
name: Carbamide
name: Urea
xref: UnificationXref6076

http://identifiers.org/pubmed/12030331
type: PublicationXref
id: 12030331
author: Badner, JA
author: Baysal, BE
author: Willett-Brozick, JE
author: Corona, W
author: Nimgaonkar, VL
author: Ferrell, RE
author: Detera-Wadleigh, SD
db: Pubmed
title: A mannosyltransferase gene at 11q23 is disrupted by a translocation breakpoint that co-segregates with bipolar affective disorder in a small family
source: Neurogenetics 4:43-53
year: 2002

Sulfate [ChEBI:16189]
type: SmallMoleculeReference
name: Sulfuric acid
name: Sulfate
xref: UnificationXref6273

UniProt:Q05567
type: ProteinReference
xref: UnificationXref4625
organism: BioSource1

http://identifiers.org/pubmed/18029057
type: PublicationXref
id: 18029057
author: Zimmermann, H
db: Pubmed
title: ATP and acetylcholine, equal brethren
source: Neurochem Int 52:634-48
year: 2008

http://identifiers.org/pubmed/10224048
type: PublicationXref
id: 10224048
author: Guo, S
author: York, JD
author: Lemrow, SM
author: Stolz, LE
db: Pubmed
title: SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases
source: J Biol Chem 274:12990-5
year: 1999

Evidence1408
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18303019
comment: After being synthesized in the ER membrane the 14-sugars lipid-linked oligosaccharide is co-translationally transferred to an unfolded protein, as described in the previous steps. After this point the N-glycan is progressively trimmed of the three glucoses and some of the mannoses before the protein is transported to the cis-Golgi. The role of these trimming reactions is that the N-glycan attached to an unfolded glycoprotein in the ER assume the role of 'tags' that direct the interactions of the glycoprotein with different elements that mediate its folding. The removal of the two outer glucoses leads to an N-glycan with only one glucose, which is a signal for the binding of either one of two chaperone proteins, calnexin (CNX) and calreticulin (CRT). These chaperones provide an environment where the protein can fold more easily. The interaction with these proteins is not transient and is terminated by the trimming of the last remaining glucose, after which the glycoprotein is released from CNX or CRT and directed to the ER Quality Control compartment (ERQC) if it still has folding defects, or transported to the Golgi if the folding is correct. The involvement of N-glycans in the folding quality control of proteins in the ER explains why this form of glycosylation is so important, and why defects in the enzymes involved in these reactions are frequently associated with congenital diseases. However, there are many unknown points in this process, as it is known that even proteins without N-glycosylation sites can be folded properly (Caramelo JJ and Parodi AJ, 2008).

UnificationXref8905
type: UnificationXref
id: 3668307
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668307

Evidence1409
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12717434
xref: http://identifiers.org/pubmed/3594573
xref: http://identifiers.org/pubmed/10412983
comment: At least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martínez-Menárguez et al, 1999). The other is mediated by LMAN1/MCFD2, mannose-binding lectins that recognize a glycan signal (Zhang B et al, 2003).

UnificationXref8906
type: UnificationXref
id: REACT_85198
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85198.9

UnificationXref8907
type: UnificationXref
id: P04912
db: UniProt

UnificationXref8908
type: UnificationXref
id: 3668102
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668102

Evidence1404
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12829701
comment: Removal of the second mannose on the alpha 1,3 branch (Frenzel Z et al, 2003).

UnificationXref8901
type: UnificationXref
id: 3668088
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668088

Evidence1405
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17499246
comment: Proteins with major folding defects are extracted from futile folding cycles in the calnexin chaperone system and the ER Quality Control Compartment, and are translocated back to the citosol for degradation. The N-glycan is used as a signal to distinguish proteins to be degraded, upon recognition by EDEM1, EDEM2 and EDEM3, three ER-stress-induced members of the glycosyl hydrolase 47 family (see Olivari S, Molinari M 2007 for a review) and OS9 (Mikami K, 2010; Hosokawa N, 2009).

UnificationXref8902
type: UnificationXref
id: 3668089
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668089

Evidence1406
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18003979
xref: http://identifiers.org/pubmed/19616933
xref: http://identifiers.org/pubmed/20347046
xref: http://identifiers.org/pubmed/11408579
comment: Proteins that are released from the CNX or CRT complex with folding defects accumulate in a compartment of the ER called ERQC (Kamhi-Nesher S et al 2001). Here, the enzymes UGGG1 or UGGG2 are able to recognize glycoproteins with minor folding process and re-add the glucose on the alpha,1,3 branch; this is a signal for the transport of these glycoproteins back to the ER, where they can interact again with CNX or CRT in order to achieve a correct folding. At the same time that the glycoprotein is in the ERQC, the enzyme ER mannosidase I progressively removes the mannoses in position 1A, 2A, B, C on the N-glycans; when the mannose on 1A is trimmed, UGGG1/UGGG2 is no longer able to re-add the glucose, and therefore the protein is destined for degradation. For years it has been thought that the removal of the mannose in position B of the N-glycan was the signal to direct proteins to degradation. However, this mechanism has been described better by Avezov et al (Avezov V et al, 2008) and it has been demonstrated that even glycoproteins with Man8 or Man7 glycans can be re-glucosylated and interact again with CNX or CRT. For a review on this topic, see Lederkremer GZ, 2009 and Määttänen P et al, 2010.

UnificationXref8903
type: UnificationXref
id: 3668090
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668090

Evidence1407
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18337472
xref: PublicationXref2778
comment: The unfolded protein is recognized by a chaperon protein (calnexin or calreticulin) and the folding process starts. The binding of these protein requires a mono-glucosylated glycan (Caramelo JJ and Parodi AJ, 2008), but in certain cases can occur even in the absence of glycosylation (Ireland BS et al, 2008).

UnificationXref8904
type: UnificationXref
id: REACT_142470
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142470.5

Evidence1400
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12145188
xref: http://identifiers.org/pubmed/10788335
comment: After the glycosylated precursor is attached to the protein, the outer alpha-1,2-linked glucose is removed by glucosidase I (MOGS, GCS1 in yeast). This is a mandatory step for the protein folding control and glycan extension, and defects in MOGS are associated with congenital disorder of glycosylation type IIb (CDGIIb) (De Praeter CM et al, 2000; Völker C et al, 2002).

Evidence1401
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10409699
xref: http://identifiers.org/pubmed/16431915
comment: The enzyme ER Man I can slowly trim up to four of the mannoses on the N-glycan on unfolded proteins accumulated in the ER. This step describes the removal of the mannose in the B position (Gonzalez et al, 1999: Hirao et al, 2006).

Evidence1402
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16431915
comment: The enzyme ER Man I can slowly trim up to four of the mannoses on the N-glycan on unfolded proteins accumulated in the ER. This step describes the removal of the mannose in the C position (Hirao et al, 2006).

Evidence1403
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12829701
xref: http://identifiers.org/pubmed/16431915
comment: The enzyme ER Man I can slowly trim up to four of the mannoses on the N-glycan on unfolded proteins accumulated in the ER. This step describes the removal of the mannose in the A position (Hirao et al, 2006; Frenkel et al, 2003).

UnificationXref8900
type: UnificationXref
id: 3668087
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668087

LPIN1:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry907
component stoichiometry: Stoichiometry908
component: Protein929
component: SmallMolecule353
xref: UnificationXref4069
cellular location: GO:0005789
comment: Reactome DB_ID: 3672211

UnificationXref8909
type: UnificationXref
id: P04911
db: UniProt

LPIN2:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry910
component stoichiometry: Stoichiometry909
component: Protein930
component: SmallMolecule353
xref: UnificationXref4070
cellular location: GO:0005789
comment: Reactome DB_ID: 3672212

http://identifiers.org/pubmed/8068008
type: PublicationXref
id: 8068008
author: Rödl, W
author: Rücknagel, KP
author: Werner, T
author: Bacher, A
author: Jaeger, E
author: Ziegler, I
author: Gütlich, M
db: Pubmed
title: Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme
source: Biochem J 302:215-21
year: 1994

LPIN
type: Complex
data source: Provenance1
member physical entity: LPIN2:Mg2+ (name copied from entity in Homo sapiens)
member physical entity: LPIN3:Mg2+ (name copied from entity in Homo sapiens)
member physical entity: LPIN1:Mg2+ (name copied from entity in Homo sapiens)
xref: UnificationXref4073
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3672215

Evidence1417
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17998403
xref: http://identifiers.org/pubmed/20214493
xref: http://identifiers.org/pubmed/17996737
xref: http://identifiers.org/pubmed/20100523
xref: http://identifiers.org/pubmed/19767391
xref: http://identifiers.org/pubmed/19720617
xref: http://identifiers.org/pubmed/17696772
xref: http://identifiers.org/pubmed/19453276
xref: http://identifiers.org/pubmed/18174896
comment: A human mitochondrion contains about 1500 proteins, more than 99% of which are encoded in the nucleus, synthesized in the cytosol and imported into the mitochondrion. Proteins are targeted to four locations (outer membrane, intermembrane space, inner membrane, and matrix) and must be sorted accordingly (reviewed in Kutik et al. 2007, Milenkovic et al. 2007, Bolender et al. 2008, Endo and Yamano 2009). Newly synthesized proteins are transported from the cytosol across the outer membrane by the TOMM40:TOMM70 complex. Proteins that contain presequences first interact with the TOMM20 subunit of the complex while proteins that contain internal targeting elements first interact with the TOMM70 subunit. After initial interaction the protein is conducted across the outer membrane by TOMM40 subunits. In yeast some proteins such as Aco1, Atp1, Cit1, Idh1, and Atp2 have both presequences that interact with TOM20 and mature regions that interact with TOM70 (Yamamoto et al. 2009). After passage across the outer membrane, proteins may be targeted to the outer membrane via the SAMM50 complex, to the inner membrane via the TIMM22 or TIMM23 complexes (reviewed in van der Laan et al. 2010), to the matrix via the TIMM23 complex (reviewed in van der Laan et al. 2010), or proteins may fold and remain in the intermembrane space (reviewed in Stojanovski et al. 2008, Deponte and Hell 2009, Sideris and Tokatlidis 2010). Presequences on matrix and inner membrane proteins cause interaction with TIMM23 complexes; internal targeting sequences cause outer membrane proteins to interact with the SAMM50 complex and inner membrane proteins to interact with the TIMM22 complex. While in the intermembrane space hydrophobic proteins are chaperoned by the TIMM8:TIMM13 complex and/or the TIMM9:TIMM10:FXC1 complex.

UnificationXref8914
type: UnificationXref
id: 3668112
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668112

CDIPT:Mg2+/Mn2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry920
component stoichiometry: Stoichiometry921
component: Protein992
component: SmallMolecule375
xref: UnificationXref4200
cellular location: GO:0005789
comment: Reactome DB_ID: 3672167

Evidence1418
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14973138
comment: The BIP (HSPA5) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

UnificationXref8915
type: UnificationXref
id: 3668113
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668113

PCYT1B dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry919
component: Protein989
xref: UnificationXref4144
cellular location: GO:0005789
comment: Reactome DB_ID: 3672178

Evidence1415
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20301232
xref: http://identifiers.org/pubmed/17988798
comment: Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoa. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. To date, there are approximately 20 genes that express mucins. Mature mucins are composed of two distinct regions: (1) The amino- and carboxy-terminal regions are very lightly glycosylated, but rich in cysteines. The cysteine residues participate in establishing disulfide linkages within and among mucin monomers. (2) A large central region rich in serine, threonine and proline residues called the variable number of tandem repeat (VNTR) region which can become heavily O-glycosylated with hundreds of O-GalNAc glycans. N-acetyl-galactosamine (GalNAc) is the first glycan to be attached, forming the simplest mucin O-glycan. After this, several different pathways are possible generating "core" structures. Four core structures are commonly formed, several others are possible but infrequent. O-linked glycans are often capped by the addition of a sialic acid residue, terminating the addition of any more O-glycans (Brockhausen et al, 2009; Tarp and Clausen, 2008).

UnificationXref8912
type: UnificationXref
id: 3668109
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668109

Evidence1416
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: After translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the body. These modifications include the internal peptide bond cleavages that activate proenzymes, the attachment of oligosaccharide moieties to membrane-bound and secreted proteins, the attachment of lipid or glycolipid moieties that serve to anchor proteins to cellular membranes, and the vitamin K-dependent attachment of carboxyl groups to glutamate residues.

UnificationXref8913
type: UnificationXref
id: 3668111
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668111

ARF1:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry923
component stoichiometry: Stoichiometry922
component: Protein592
component: SmallMolecule395
xref: UnificationXref4311
cellular location: GO:0000139
comment: Reactome DB_ID: 3672371

UnificationXref8918
type: UnificationXref
id: REACT_143494
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143494.5

PISD:Pyruvoyl (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry913
component stoichiometry: Stoichiometry915
component stoichiometry: Stoichiometry914
component: Protein980
component: SmallMolecule356
component: Protein981
xref: UnificationXref4088
cellular location: GO:0005743
comment: Reactome DB_ID: 3672223

UnificationXref8919
type: UnificationXref
id: 3673173
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673173

LPIN3:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry911
component stoichiometry: Stoichiometry912
component: Protein979
component: SmallMolecule353
xref: UnificationXref4072
cellular location: GO:0005789
comment: Reactome DB_ID: 3672214

Hypusine synthesis from eIF5A-lysine
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction807
pathway component: BiochemicalReaction808
pathway component: BiochemicalReaction809
evidence: Evidence1365
xref: RelationshipXref1140
xref: UnificationXref9421
xref: UnificationXref9422
pathway order: PathwayStep1364
pathway order: PathwayStep1366
pathway order: PathwayStep1365
display name: Hypusinylation
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence1419
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10856300
xref: http://identifiers.org/pubmed/14973138
xref: http://identifiers.org/pubmed/10866666
xref: http://identifiers.org/pubmed/10958673
comment: The N-terminal fragment of ATF6-alpha contains a bZIP domain and binds the sequence CCACG in ER Stress Response Elements (ERSEs). ATF6-alpha binds ERSEs together with the heterotrimeric transcription factor NF-Y, which binds the sequence CCAAT in the ERSEs, and together the two factors activate transcription of ER stress-responsive genes. Evidence from overexpression and knockdowns indicates that ATF6-alpha is a potent activator but its homolog ATF6-beta is not and ATF6-beta may actually reduce expression of ER stress proteins.

UnificationXref8916
type: UnificationXref
id: REACT_140946
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140946.5

PCYT1A dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry918
component: Protein988
xref: UnificationXref4142
cellular location: GO:0005789
comment: Reactome DB_ID: 3672176

UnificationXref8917
type: UnificationXref
id: 3673182
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673182

PCYT1 dimer
type: Complex
data source: Provenance1
member physical entity: PCYT1B dimer (name copied from entity in Homo sapiens)
member physical entity: PCYT1A dimer (name copied from entity in Homo sapiens)
xref: UnificationXref4145
cellular location: GO:0005789
comment: Reactome DB_ID: 3672179
comment: Converted from EntitySet in Reactome

Evidence1410
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20301244
xref: http://identifiers.org/pubmed/20301507
xref: http://identifiers.org/pubmed/19616933
xref: http://identifiers.org/pubmed/10580125
xref: http://identifiers.org/pubmed/19647993
xref: http://identifiers.org/pubmed/16807922
comment: N-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley P et al, 2009). An early study in 1999 revealed that about 50% of the proteins in the Swiss-Prot database at the time were N-glycosylated (Apweiler R et al, 1999). It is now established that the majority of the proteins in the secretory pathway require glycosylation in order to achieve proper folding. The addition of an N-glycan to a protein can have several roles (Shental-Bechor D and Levy Y, 2009). First, glycans enhance the solubility and stability of the proteins in the ER, the golgi and on the outside of the cell membrane, where the composition of the medium is strongly hydrophilic and where proteins, that are mostly hydrophobic, have difficulty folding properly. Second, N-glycans are used as signal molecules during the folding and transport process of the protein: they have the role of labels to determine when a protein must interact with a chaperon, be transported to the golgi, or targeted for degradation in case of major folding defects. Third, and most importantly, N-glycans on completely folded proteins are involved in a wide range of processes: they help determine the specificity of membrane receptors in innate immunity or in cell-to-cell interactions, they can change the properties of hormones and secreted proteins, or of the proteins in the vesicular system inside the cell. All N-linked glycans are derived from a common 14-sugar oligosaccharide synthesized in the ER, which is attached co-translationally to a protein while this is being translated inside the reticulum. The process of the synthesis of this glycan, known as Synthesis of the N-glycan precursor or LLO, constitutes one of the most conserved pathways in eukaryotes, and has been also observed in some eubacteria. The attachment usually happens on an asparagine residue within the consensus sequence asparagine-X-threonine by an complex calle…

Evidence1413
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2787
comment: An unknown N-acetylgalactosaminyltransferase mediates the transfer of GalNAc is transferred to Tn antigens via an alpha-1,6 linkage to create Core 7 mucins (Brockhausen et al. 2009).

UnificationXref8910
type: UnificationXref
id: 3668106
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668106

http://identifiers.org/pubmed/15761154
type: PublicationXref
id: 15761154
author: Pack, M
author: Chang, H
author: Delamarre, L
author: Trombetta, ES
author: Mellman, I
db: Pubmed
title: Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate
source: Science 307:1630-4
year: 2005

Evidence1414
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2787
comment: An unknown galactosyltransferase mediates the transfer of galactose is transferred to Tn antigens via an alpha-1,3 linkage to create Core 8 mucins (Brockhausen et al. 2009).

UnificationXref8911
type: UnificationXref
id: 3668107
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668107

Evidence1411
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2787
comment: An unknown N-acetylglucosaminyltransferase mediates the transfer of GlcNAc to Tn antigens via an alpha-1,3 linkage to create Core 5 mucins (Brockhausen et al. 2009).

Evidence1412
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2787
comment: An unknown N-acetylglucosaminyltransferase mediates the transfer of GlcNAc to Tn antigens via an beta-1,6 linkage to create Core 6 mucins (Brockhausen et al. 2009).

http://identifiers.org/pubmed/18048764
type: PublicationXref
id: 18048764
author: Eizirik, DL
author: Cnop, M
author: Cardozo, AK
db: Pubmed
title: The role for endoplasmic reticulum stress in diabetes mellitus
source: Endocr Rev 29:42-61
year: 2008

ARF1/3:GTP:PI4KB (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry924
component stoichiometry: Stoichiometry925
component: Note: the coordinates are copied over from Homo sapiens.
component: ARF1:GTP (name copied from entity in Homo sapiens)
xref: UnificationXref4313
cellular location: GO:0000139
comment: Reactome DB_ID: 3672372

PIK3C3:Mn2+:PIK3R4:Mn2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry928
component stoichiometry: Stoichiometry931
component: PIK3C3:Mn2+ (name copied from entity in Homo sapiens)
component: PIK3R4:Mn2+ (name copied from entity in Homo sapiens)
xref: UnificationXref4330
cellular location: GO:0005829
comment: Reactome DB_ID: 3672385

PIK3R4:Mn2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry927
component stoichiometry: Stoichiometry926
component: SmallMolecule155
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4326
cellular location: GO:0005829
comment: Reactome DB_ID: 3672384

PIK3C3:Mn2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry930
component stoichiometry: Stoichiometry929
component: SmallMolecule155
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4329
cellular location: GO:0005829
comment: Reactome DB_ID: 3672383

Evidence1426
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16539657
comment: The DDX11 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

UnificationXref8923
type: UnificationXref
id: 3668097
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668097

Evidence1427
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10827079
comment: The DNAJB11 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

UnificationXref8924
type: UnificationXref
id: REACT_100315
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100315.9

TCR signaling
type: Pathway
data source: Provenance1
pathway component: REACT 30739.10
evidence: Evidence1286
xref: UnificationXref9095
xref: UnificationXref9096
xref: RelationshipXref1101
pathway order: PathwayStep1289
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence1428
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16461360
comment: The EDEM gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

UnificationXref8925
type: UnificationXref
id: 3673177
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673177

GGT1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry944
component stoichiometry: Stoichiometry943
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4553
cellular location: GO:0005886
comment: Reactome DB_ID: 3670181

Evidence1429
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16539657
comment: The GFPT1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

UnificationXref8926
type: UnificationXref
id: REACT_98075
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98075.9

GGT1/5 dimer
type: Complex
data source: Provenance1
member physical entity: GGT1 dimer (name copied from entity in Homo sapiens)
member physical entity: GGT5 dimer (name copied from entity in Homo sapiens)
xref: UnificationXref4557
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3670185

UnificationXref8927
type: UnificationXref
id: 3673178
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673178

LTA4H:Zn2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry942
component stoichiometry: Stoichiometry941
component: Note: the coordinates are copied over from Homo sapiens.
component: SmallMolecule430
xref: UnificationXref4530
cellular location: GO:0005829
comment: Reactome DB_ID: 3670203

UnificationXref8928
type: UnificationXref
id: REACT_28281
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28281.10

PIKFYVE:VAC14:FIG4 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry939
component stoichiometry: Stoichiometry938
component stoichiometry: Stoichiometry940
component: Q06708
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4422
cellular location: late endosome membrane
comment: Reactome DB_ID: 3672364

http://identifiers.org/pubmed/16543958
type: PublicationXref
id: 16543958
author: Hirsch, E
author: Rommel, C
author: Barberis, L
author: Montrucchio, G
author: Lembo, G
author: Costa, C
db: Pubmed
title: Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing
source: Thromb Haemost 95:29-35
year: 2006

UnificationXref8929
type: UnificationXref
id: 3673179
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673179

PIKFYVE:VAC14:FIG4 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry937
component stoichiometry: Stoichiometry936
component stoichiometry: Stoichiometry935
component: Note: the coordinates are copied over from Homo sapiens.
component: Q06708
xref: UnificationXref4399
cellular location: early endosome membrane
comment: Reactome DB_ID: 3672419

PIKFYVE:VAC14:FIG4 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry933
component stoichiometry: Stoichiometry934
component stoichiometry: Stoichiometry932
component: Note: the coordinates are copied over from Homo sapiens.
component: Q06708
xref: UnificationXref4344
cellular location: GO:0000139
comment: Reactome DB_ID: 3672380

Evidence1420
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18436705
xref: http://identifiers.org/pubmed/18048764
xref: http://identifiers.org/pubmed/18038217
comment: ATF6-alpha is a transmembrane protein that normally resides in the Endoplasmic Reticulum (ER) membrane. Here its luminal C-terminal domain is associated with BiP, shielding 2 Golgi-targeting regions and thus keeping ATF6-alpha in the ER. Upon interaction of BiP with unfolded proteins in the ER, ATF6-alpha dissociates and transits to the Golgi where it is cleaved by the S1P and S2P proteases that reside in the Golgi, releasing the N-terminal domain of ATF6-alpha into the cytosol. After transiting to the nucleus, the N-terminal domain acts as a transcription factor to activate genes encoding chaperones.

Evidence1421
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16365312
xref: http://identifiers.org/pubmed/10835430
xref: http://identifiers.org/pubmed/16973740
xref: http://identifiers.org/pubmed/11897784
xref: http://identifiers.org/pubmed/11069889
xref: http://identifiers.org/pubmed/18191223
comment: The dissociation of the IRE1-alpha:BiP heterodimer liberates IRE1-alpha, which forms homodimers. Dimer formation is initiated by interaction between the N-terminal, luminal domains.

Evidence1422
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9637683
xref: http://identifiers.org/pubmed/16973740
xref: http://identifiers.org/pubmed/11069889
comment: Dimerization of the N-terminal luminal regions of IRE1-alpha brings the cytosolic C-terminal regions in proximity. The C-terminal region possesses kinase activity and the homodimer trans-autophosphorylates. From homology with Saccharomyces IRE1-alpha the phosphorylation of human IRE1-alpha is believed to be at Ser724.

Evidence1423
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16539657
comment: The ATP6VOD1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

UnificationXref8920
type: UnificationXref
id: REACT_102349
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102349.9

Evidence1424
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16539657
comment: The CTDSP2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

UnificationXref8921
type: UnificationXref
id: 3668095
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668095

Evidence1425
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16539657
comment: The CXXC1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

UnificationXref8922
type: UnificationXref
id: 3668096
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668096

SPTLC1:SPTLC3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry949
component stoichiometry: Stoichiometry950
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4576
cellular location: GO:0005789
comment: Reactome DB_ID: 3670730

Active N-SMase:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry951
component stoichiometry: Stoichiometry952
component: Note: the coordinates are copied over from Homo sapiens.
component: SmallMolecule448
xref: UnificationXref4657
cellular location: GO:0005886
comment: Reactome DB_ID: 3669357

serine palymitoyltransferase
type: Complex
data source: Provenance1
member physical entity: SPTLC1:SPTLC3 (name copied from entity in Homo sapiens)
member physical entity: SPTLC1:SPTLC2 (name copied from entity in Homo sapiens)
xref: UnificationXref4577
cellular location: GO:0005789
display name: SPTLC 2 or 3 complexes
comment: Reactome DB_ID: 3670731
comment: Converted from EntitySet in Reactome

SPTLC1:SPTLC2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry947
component stoichiometry: Stoichiometry948
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4574
cellular location: GO:0005789
comment: Reactome DB_ID: 3670727

GGT5 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry946
component stoichiometry: Stoichiometry945
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4556
cellular location: GO:0005886
comment: Reactome DB_ID: 3670184

UniProt:P38829 YHR122W
type: ProteinReference
name: YHR122W
xref: UnificationXref6651
comment: FUNCTION May play a role in chromosome segregation through establishment of sister chromatid cohesion.MISCELLANEOUS Present with 1800 molecules/cell in log phase SD medium.SIMILARITY Belongs to the MIP18 family.
organism: BioSource1

http://identifiers.org/pubmed/9748295
type: PublicationXref
id: 9748295
author: Brown, MS
author: Guryev, O
author: Goldstein, JL
author: Pai, JT
db: Pubmed
title: Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins
source: J Biol Chem 273:26138-48
year: 1998

http://identifiers.org/pubmed/12480933
type: PublicationXref
id: 12480933
author: Indiani, C
author: Davey, MJ
author: O'Donnell, M
db: Pubmed
title: Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture
source: J Biol Chem 278:4491-9
year: 2003

http://identifiers.org/pubmed/9706223
type: PublicationXref
id: 9706223
author: Kerner, J
author: Hoppel, C
db: Pubmed
title: Genetic disorders of carnitine metabolism and their nutritional management.
source: Annu Rev Nutr 18:179-206
year: 1998

monomethylated residue
type: SequenceModificationVocabulary
xref: UnificationXref2439

UniProt:P38822
type: ProteinReference
xref: UnificationXref8654
organism: BioSource1

UniProt:P38820
type: ProteinReference
xref: UnificationXref5755
organism: BioSource1

UniProt:P38810
type: ProteinReference
xref: UnificationXref1777
organism: BioSource1

cholest-5-en-3beta-ol
type: SmallMoleculeReference
name: cholesterol
name: cholesterol [ChEBI:16113]
xref: UnificationXref3250

Phosphatidyl-N-trimethylethanolamine
type: SmallMoleculeReference
name: Choline phosphatide
name: 1,2-diacyl-sn-glycero-3-phosphocholine
name: Phosphatidylcholine
name: Lecithin
name: lecithins
name: L-alpha-phosphatidylcholine
name: 1,2-diacyl-sn-glycero-3-phosphocholines
name: PC
name: (3-sn-phosphatidyl)choline
name: 1,2-diacyl-sn-glycero-3-phosphocholine [ChEBI:16110]
xref: UnificationXref4030

Dihydroxyacetone phosphate
type: SmallMoleculeReference
name: Glycerone phosphate
name: Dihydroxyacetone phosphate [ChEBI:16108]
xref: UnificationXref2651

Capping complex (GpppN..) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry613
component stoichiometry: Stoichiometry611
component stoichiometry: Stoichiometry612
component: CE:Pol II CTD:Spt5 complex (name copied from entity in Homo sapiens)
component: PhysicalEntity74
component: PhysicalEntity69
xref: UnificationXref2361
cellular location: GO:0005654
comment: Reactome DB_ID: 3668258

Capping complex (with freed 5'- GMP) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry616
component stoichiometry: Stoichiometry614
component stoichiometry: Stoichiometry615
component: PhysicalEntity75
component: CE:Pol II CTD:Spt5 complex (name copied from entity in Homo sapiens)
component: PhysicalEntity69
xref: UnificationXref2366
cellular location: GO:0005654
comment: Reactome DB_ID: 3668261

RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry617
component stoichiometry: Stoichiometry618
component: RNA polymerase II (phosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: PhysicalEntity76
xref: UnificationXref2371
cellular location: GO:0005654
comment: Reactome DB_ID: 3666810

Cap Binding Complex (CBC) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry619
component stoichiometry: Stoichiometry620
component: Protein258
component: Protein257
xref: UnificationXref2372
cellular location: GO:0005654
comment: Reactome DB_ID: 3666756

capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry622
component stoichiometry: Stoichiometry621
component: RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA (name copied from entity in Homo sapiens)
component: Cap Binding Complex (CBC) (name copied from entity in Homo sapiens)
xref: UnificationXref2373
cellular location: GO:0005654
comment: Reactome DB_ID: 3666811

RNA Pol II with phosphorylated CTD: CE complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry623
component stoichiometry: Stoichiometry624
component stoichiometry: Stoichiometry626
component stoichiometry: Stoichiometry625
component: TFIIH (name copied from entity in Homo sapiens)
component: RNA polymerase II (phosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: PhysicalEntity71
component: PhysicalEntity72
xref: UnificationXref2378
cellular location: GO:0005654
comment: Reactome DB_ID: 3668232

ADAR1 homodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry628
component: Protein722
xref: UnificationXref2387
cellular location: GO:0005654
comment: Reactome DB_ID: 3668080

UnificationXref8771
type: UnificationXref
id: 3668460
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668460

UnificationXref8770
type: UnificationXref
id: 3668459
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668459

UniProt:P38604
type: ProteinReference
xref: UnificationXref3725
organism: BioSource1

http://identifiers.org/pubmed/17475546
type: PublicationXref
id: 17475546
author: Heikkinen, S
author: Argmann, CA
author: Auwerx, J
db: Pubmed
title: PPARgamma in human and mouse physiology
source: Biochim Biophys Acta 1771:999-1013
year: 2007

Capping complex (hydrolyzed) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry604
component stoichiometry: Stoichiometry605
component stoichiometry: Stoichiometry603
component: CE:Pol II CTD:Spt5 complex (name copied from entity in Homo sapiens)
component: PhysicalEntity73
component: PhysicalEntity69
xref: UnificationXref2347
cellular location: GO:0005654
comment: Reactome DB_ID: 3668251

Capping complex (intermediate) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry609
component stoichiometry: Stoichiometry606
component stoichiometry: Stoichiometry610
component: Covalent CE:GMP intermediate complex (name copied from entity in Homo sapiens)
component: PhysicalEntity73
component: PhysicalEntity69
xref: UnificationXref2354
cellular location: GO:0005654
comment: Reactome DB_ID: 3668255

Covalent CE:GMP intermediate complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry607
component stoichiometry: Stoichiometry608
component: CE:Pol II CTD:Spt5 complex (name copied from entity in Homo sapiens)
component: SmallMolecule114
xref: UnificationXref2353
cellular location: GO:0005654
comment: Reactome DB_ID: 3668254

UnificationXref8767
type: UnificationXref
id: REACT_81078
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81078.9

UnificationXref8768
type: UnificationXref
id: 110182
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110182

UnificationXref8765
type: UnificationXref
id: 3668457
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668457

UnificationXref8766
type: UnificationXref
id: 3668458
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668458

UnificationXref8763
type: UnificationXref
id: P53397
db: UniProt

UnificationXref8764
type: UnificationXref
id: 3668456
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668456

UnificationXref8761
type: UnificationXref
id: 110184
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110184

UnificationXref8762
type: UnificationXref
id: REACT_2574
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2574.1

UnificationXref8769
type: UnificationXref
id: REACT_2338
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2338.1

CE:Pol II CTD:Spt5 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry595
component stoichiometry: Stoichiometry597
component stoichiometry: Stoichiometry596
component stoichiometry: Stoichiometry578
component stoichiometry: Stoichiometry599
component stoichiometry: Stoichiometry598
component: TFIIH (name copied from entity in Homo sapiens)
component: RNA polymerase II (phosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: PhysicalEntity71
component: PhysicalEntity72
component: Protein720
component: Protein721
xref: UnificationXref2339
cellular location: GO:0005654
comment: Reactome DB_ID: 3668247

TFIIH (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry573
component stoichiometry: Stoichiometry572
component stoichiometry: Stoichiometry576
component stoichiometry: Stoichiometry574
component stoichiometry: Stoichiometry571
component stoichiometry: Stoichiometry577
component stoichiometry: Stoichiometry575
component: Complex79
component: Protein705
component: Protein702
component: Protein701
component: Protein704
component: Protein706
component: Protein703
xref: UnificationXref2301
cellular location: GO:0005654
comment: Reactome DB_ID: 3667650

PPA1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry568
component: Protein695
xref: UnificationXref2265
cellular location: GO:0005829
comment: Reactome DB_ID: 3666743

PPA2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry570
component: Protein698
xref: UnificationXref2277
cellular location: GO:0005759
comment: Reactome DB_ID: 3671154

TFIIF (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry593
component stoichiometry: Stoichiometry592
component: Protein719
component: Protein718
xref: UnificationXref2330
cellular location: GO:0005654
comment: Reactome DB_ID: 3666808

Capping complex (initial) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry601
component stoichiometry: Stoichiometry600
component stoichiometry: Stoichiometry602
component: CE:Pol II CTD:Spt5 complex (name copied from entity in Homo sapiens)
component: PhysicalEntity68
component: PhysicalEntity69
xref: UnificationXref2340
cellular location: GO:0005654
comment: Reactome DB_ID: 3668249

RNA polymerase II (phosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry591
component stoichiometry: Stoichiometry594
component: RNA Polymerase II holoenzyme complex (phosphorylated) (name copied from entity in Homo sapiens)
component: TFIIF (name copied from entity in Homo sapiens)
xref: UnificationXref2331
cellular location: GO:0005654
comment: Reactome DB_ID: 3666809

RNA Polymerase II holoenzyme complex (phosphorylated) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry588
component stoichiometry: Stoichiometry582
component stoichiometry: Stoichiometry581
component stoichiometry: Stoichiometry587
component stoichiometry: Stoichiometry580
component stoichiometry: Stoichiometry586
component stoichiometry: Stoichiometry584
component stoichiometry: Stoichiometry590
component stoichiometry: Stoichiometry589
component stoichiometry: Stoichiometry583
component stoichiometry: Stoichiometry579
component stoichiometry: Stoichiometry585
component: Protein717
component: Protein712
component: Protein714
component: Protein709
component: Protein707
component: Protein716
component: Protein710
component: Protein711
component: Protein708
component: Protein713
component: Protein715
component: PhysicalEntity70
xref: UnificationXref2325
cellular location: GO:0005654
comment: Reactome DB_ID: 3666799

http://identifiers.org/pubmed/12914699
type: PublicationXref
id: 12914699
author: Kettenberger, H
author: Armache, KJ
author: Cramer, P
db: Pubmed
title: Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage.
source: Cell 114:347-57
year: 2003

UnificationXref8760
type: UnificationXref
id: REACT_115204
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115204.8

http://identifiers.org/pubmed/12914698
type: PublicationXref
id: 12914698
author: Wriggers, W
author: Chlenov, M
author: Opalka, N
author: Darst, SA
author: Chacon, P
author: Rice, WJ
db: Pubmed
title: Structure and function of the transcription elongation factor GreB bound to bacterial RNA polymerase.
source: Cell 114:335-45
year: 2003

FGFR1 fusion mutant dimers:TKIs (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry564
component stoichiometry: Stoichiometry565
component: FGFR1 fusion mutant dimers
component: SmallMolecule93
xref: UnificationXref2174
cellular location: GO:0005829
comment: Reactome DB_ID: 3672575

Formation of tubulin folding intermediates by CCT/TriC
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction805
evidence: Evidence1356
xref: RelationshipXref1133
xref: UnificationXref9365
xref: UnificationXref9366
pathway order: PathwayStep1357
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

CCBL1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry566
component: Protein690
xref: UnificationXref2200
cellular location: GO:0005829
comment: Reactome DB_ID: 3671486

UnificationXref8754
type: UnificationXref
id: REACT_154569
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154569.3

UnificationXref8755
type: UnificationXref
id: 3673218
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673218

UnificationXref8756
type: UnificationXref
id: REACT_153507
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153507.3

Glucuronidation
type: Pathway
data source: Provenance1
pathway component: REACT 34051.10
evidence: Evidence838
xref: UnificationXref6449
xref: UnificationXref6450
xref: RelationshipXref844
pathway order: PathwayStep839
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8757
type: UnificationXref
id: 3673219
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673219

UnificationXref8750
type: UnificationXref
id: REACT_166391
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_166391.1

UnificationXref8751
type: UnificationXref
id: 3673225
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673225

UnificationXref8752
type: UnificationXref
id: REACT_145300
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145300.5

UnificationXref8753
type: UnificationXref
id: 3673217
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673217

CUX1-p-FGFR1 fusion mutant dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry562
component: Protein689
xref: UnificationXref2156
cellular location: GO:0005829
comment: Reactome DB_ID: 3672580

UnificationXref8758
type: UnificationXref
id: REACT_145541
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145541.5

UnificationXref8759
type: UnificationXref
id: 3673166
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673166

p-ERK dimer
type: Complex
data source: Provenance1
member physical entity: phospho-ERK-1 dimer (name copied from entity in Homo sapiens)
member physical entity: phospho-ERK-2 dimer (name copied from entity in Homo sapiens)
xref: UnificationXref2143
cellular location: GO:0005829
comment: Reactome DB_ID: 3672031
comment: Converted from EntitySet in Reactome

FGFR1 fusion mutant dimers
type: Complex
data source: Provenance1
member physical entity: CUX1-FGFR1 fusion mutant dimer (name copied from entity in Homo sapiens)
xref: UnificationXref2152
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3672573

UniProt:P38620
type: ProteinReference
xref: UnificationXref3056
organism: BioSource1

CUX1-FGFR1 fusion mutant dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry559
component: Protein688
xref: UnificationXref2151
cellular location: GO:0005829
comment: Reactome DB_ID: 3672572

p-FGFR1 fusion mutant dimers
type: Complex
data source: Provenance1
member physical entity: CUX1-p-FGFR1 fusion mutant dimer (name copied from entity in Homo sapiens)
xref: UnificationXref2157
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3672581

PDPK1:PIP3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry550
component stoichiometry: Stoichiometry549
component: SmallMolecule85
component: Protein680
xref: UnificationXref2089
cellular location: GO:0005886
comment: Reactome DB_ID: 3672794

PDPK1:PIP2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry551
component stoichiometry: Stoichiometry552
component: SmallMolecule86
component: Protein680
xref: UnificationXref2095
cellular location: GO:0005886
comment: Reactome DB_ID: 3672790

HSP90 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry553
component: Protein684
xref: UnificationXref2109
cellular location: GO:0005829
comment: Reactome DB_ID: 3671946

HSP90:Benzoquinoid ansamycins (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry555
component stoichiometry: Stoichiometry556
component: SmallMolecule87
component: HSP90 (name copied from entity in Homo sapiens)
xref: UnificationXref2127
cellular location: GO:0005829
comment: Reactome DB_ID: 3671947

UniProt:P38627
type: ProteinReference
xref: UnificationXref5413
organism: BioSource1

UniProt:P38628
type: ProteinReference
xref: UnificationXref9532
organism: BioSource1

UniProt:P38629
type: ProteinReference
xref: UnificationXref1189
organism: BioSource1

phospho-ERK-2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry548
component: Protein673
xref: UnificationXref2064
cellular location: GO:0005654
comment: Reactome DB_ID: 3668379

UniProt:P38624
type: ProteinReference
xref: UnificationXref1100
organism: BioSource1

UniProt:P38625
type: ProteinReference
xref: UnificationXref5100
organism: BioSource1

UnificationXref8741
type: UnificationXref
id: 3673045
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673045

UnificationXref8742
type: UnificationXref
id: 3673051
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673051

UnificationXref8740
type: UnificationXref
id: 3673036
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673036

UnificationXref8745
type: UnificationXref
id: 3673054
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673054

UnificationXref8746
type: UnificationXref
id: REACT_167289
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_167289.1

UnificationXref8743
type: UnificationXref
id: 3673052
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673052

UnificationXref8744
type: UnificationXref
id: 3673053
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673053

UnificationXref8749
type: UnificationXref
id: 3673440
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673440

UnificationXref8747
type: UnificationXref
id: 3673439
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673439

UnificationXref8748
type: UnificationXref
id: REACT_165989
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_165989.1

phospho-ERK-2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry547
component: Protein670
xref: UnificationXref2058
cellular location: GO:0005829
comment: Reactome DB_ID: 3668369

phospho-ERK-1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry545
component: Protein667
xref: UnificationXref2050
cellular location: GO:0005654
comment: Reactome DB_ID: 3668374

cAMP:PKA regulatory subunit (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry542
component stoichiometry: Stoichiometry541
component: Protein657
component: SmallMolecule84
xref: UnificationXref2018
cellular location: GO:0005829
comment: Reactome DB_ID: 3668557

phospho-ERK-1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry544
component: Protein664
xref: UnificationXref2044
cellular location: GO:0005829
comment: Reactome DB_ID: 3668360

ATP6V1B trimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry532
component: Protein644
xref: UnificationXref1981
cellular location: GO:0005829
comment: Reactome DB_ID: 3667938

UniProt:P38630
type: ProteinReference
xref: UnificationXref1197
organism: BioSource1

PKA tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry539
component stoichiometry: Stoichiometry538
component: Protein657
component: Protein653
xref: UnificationXref2017
cellular location: GO:0005829
comment: Reactome DB_ID: 3668556

ATP6V1A trimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry524
component: Protein634
xref: UnificationXref1961
cellular location: GO:0005829
comment: Reactome DB_ID: 3667931

ATP6V1G dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry526
component: Protein635
xref: UnificationXref1966
cellular location: GO:0005829
comment: Reactome DB_ID: 3667965

ATP6V0E (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry519
component stoichiometry: Stoichiometry520
component: PhysicalEntity65
component: PhysicalEntity66
xref: UnificationXref1953
cellular location: GO:0030670
comment: Reactome DB_ID: 3671970

ATP6V1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry528
component stoichiometry: Stoichiometry533
component stoichiometry: Stoichiometry531
component stoichiometry: Stoichiometry527
component stoichiometry: Stoichiometry523
component stoichiometry: Stoichiometry529
component stoichiometry: Stoichiometry530
component stoichiometry: Stoichiometry525
component: ATP6V1G dimer (name copied from entity in Homo sapiens)
component: Protein639
component: Protein638
component: Protein641
component: ATP6V1A trimer (name copied from entity in Homo sapiens)
component: Protein640
component: ATP6V1B trimer (name copied from entity in Homo sapiens)
component: Protein631
xref: UnificationXref1982
cellular location: GO:0005829
comment: Reactome DB_ID: 3667970

UnificationXref8730
type: UnificationXref
id: 3673441
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673441

UnificationXref8731
type: UnificationXref
id: REACT_167112
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_167112.1

UnificationXref8732
type: UnificationXref
id: Q08826
db: UniProt

UnificationXref8733
type: UnificationXref
id: 3673050
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673050

http://identifiers.org/pubmed/12450384
type: PublicationXref
id: 12450384
author: Zhang, Y
author: Desharnais, J
author: Beardsley, GP
author: Wilson, IA
author: Greasley, SE
author: Boger, DL
db: Pubmed
title: Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR
source: Biochemistry 41:14206-14215
year: 2002

UnificationXref8734
type: UnificationXref
id: 3673046
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673046

UnificationXref8735
type: UnificationXref
id: P34110
db: UniProt

UnificationXref8736
type: UnificationXref
id: 3673044
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673044

UnificationXref8737
type: UnificationXref
id: P38759
db: UniProt

UnificationXref8738
type: UnificationXref
id: 3673040
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673040

http://identifiers.org/pubmed/2780561
type: PublicationXref
id: 2780561
author: Moyzis, RK
author: Ratliff, RL
author: Meyne, J
db: Pubmed
title: Conservation of the human telomere sequence (TTAGGG)n among vertebrates
source: Proc Natl Acad Sci U S A 86:7049-53
year: 1989

UnificationXref8739
type: UnificationXref
id: P40335
db: UniProt

ATP6V0C hexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry516
component: Protein629
xref: UnificationXref1948
cellular location: GO:0030670
comment: Reactome DB_ID: 3671964

ATP6V0A (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry512
component stoichiometry: Stoichiometry511
component stoichiometry: Stoichiometry513
component stoichiometry: Stoichiometry514
component: Protein623
component: Protein626
component: Protein620
component: Protein617
xref: UnificationXref1945
cellular location: GO:0030670
comment: Reactome DB_ID: 3671961

ATP6V0D (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry509
component stoichiometry: Stoichiometry508
component: Protein616
component: Protein615
xref: UnificationXref1930
cellular location: GO:0030670
comment: Reactome DB_ID: 3671967

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-oate
type: SmallMoleculeReference
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate [ChEBI:1698]
xref: UnificationXref3863

Pyridoxal 5'-phosphate
type: SmallMoleculeReference
name: Pyridoxal 5-phosphate
name: Pyridoxal phosphate
name: Pyridoxal phosphate [ChEBI:18405]
xref: UnificationXref444

ESCRT-II (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry492
component stoichiometry: Stoichiometry491
component stoichiometry: Stoichiometry493
component: Protein602
component: Protein603
component: Protein604
xref: UnificationXref1884
cellular location: GO:0005829
comment: Reactome DB_ID: 3671638

ESCRT-III/Cargo Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry501
component stoichiometry: Stoichiometry500
component: ESCRT-III (name copied from entity in Homo sapiens)
component: Ubiquinated and PIP3 Endosmal Membrane Bound Cargo (name copied from entity in Homo sapiens)
xref: UnificationXref1899
cellular location: GO:0010008
comment: Reactome DB_ID: 3671625

ESCRT-III (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry498
component stoichiometry: Stoichiometry497
component stoichiometry: Stoichiometry495
component stoichiometry: Stoichiometry496
component stoichiometry: Stoichiometry499
component: Protein607
component: Protein608
component: PhysicalEntity64
component: Protein605
component: Protein606
xref: UnificationXref1898
cellular location: GO:0005829
comment: Reactome DB_ID: 3671622

RAB8A/10/13/14:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry504
component stoichiometry: Stoichiometry505
component: Protein612
component: SmallMolecule80
xref: UnificationXref1914
cellular location: GO:0030659
comment: Reactome DB_ID: 3672077

RAB8A/10/13/14:GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry503
component stoichiometry: Stoichiometry502
component: Protein612
component: SmallMolecule81
xref: UnificationXref1913
cellular location: GO:0030659
comment: Reactome DB_ID: 3672078

ATP6V0 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry518
component stoichiometry: Stoichiometry521
component stoichiometry: Stoichiometry517
component stoichiometry: Stoichiometry515
component stoichiometry: Stoichiometry510
component: ATP6V0E (name copied from entity in Homo sapiens)
component: ATP6V0D (name copied from entity in Homo sapiens)
component: Protein630
component: ATP6V0A (name copied from entity in Homo sapiens)
component: ATP6V0C hexamer (name copied from entity in Homo sapiens)
xref: UnificationXref1954
cellular location: GO:0030670
comment: Reactome DB_ID: 3671971

http://identifiers.org/pubmed/12766759
type: PublicationXref
id: 12766759
author: Inohara, N
author: Nunez, G
db: Pubmed
title: NODs: intracellular proteins involved in inflammation and apoptosis
source: Nat Rev Immunol 3:371-82
year: 2003

V-ATPase (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry534
component stoichiometry: Stoichiometry522
component: ATP6V1 (name copied from entity in Homo sapiens)
component: ATP6V0 (name copied from entity in Homo sapiens)
xref: UnificationXref1983
cellular location: GO:0030670
comment: Reactome DB_ID: 3671972

Arf1-GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry485
component stoichiometry: Stoichiometry484
component: Protein592
component: SmallMolecule77
xref: UnificationXref1850
cellular location: GO:0000139
comment: Reactome DB_ID: 3669695

http://identifiers.org/pubmed/10441588
type: PublicationXref
id: 10441588
author: Li, TK
author: Chen, CC
author: Wang, MF
author: Chen, YC
author: Chang, YC
author: Yin, SJ
author: Lu, RB
db: Pubmed
title: Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.
source: Am J Hum Genet 65:795-807
year: 1999

Arf1-GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry486
component stoichiometry: Stoichiometry487
component: Protein598
component: SmallMolecule78
xref: UnificationXref1865
cellular location: GO:0005829
comment: Reactome DB_ID: 3670212

ESCRT-II/Cargo Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry494
component stoichiometry: Stoichiometry490
component: Ubiquinated and PIP3 Endosmal Membrane Bound Cargo (name copied from entity in Homo sapiens)
component: ESCRT-II (name copied from entity in Homo sapiens)
xref: UnificationXref1885
cellular location: GO:0010008
comment: Reactome DB_ID: 3671639

UnificationXref8729
type: UnificationXref
id: REACT_166790
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_166790.1

Ubiquinated and PIP3 Endosmal Membrane Bound Cargo (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry488
component stoichiometry: Stoichiometry489
component: SmallMolecule79
component: Protein601
xref: UnificationXref1877
cellular location: GO:0010008
comment: Reactome DB_ID: 3671624

UnificationXref8728
type: UnificationXref
id: 3673438
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673438

UnificationXref8727
type: UnificationXref
id: REACT_133429
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133429.5

UnificationXref8726
type: UnificationXref
id: 3673254
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673254

UnificationXref8725
type: UnificationXref
id: REACT_130868
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130868.5

UnificationXref8724
type: UnificationXref
id: 3673253
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673253

UnificationXref8723
type: UnificationXref
id: REACT_127474
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127474.5

UnificationXref8722
type: UnificationXref
id: 3673489
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673489

UnificationXref8721
type: UnificationXref
id: REACT_106868
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106868.9

UnificationXref8720
type: UnificationXref
id: 3673312
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673312

5'-Phosphoribosyl-5-amino-4-imidazolecarboxamide
type: SmallMoleculeReference
name: 5-Phosphoribosyl-4-carbamoyl-5-aminoimidazole
name: 5-Aminoimidazole-4-carboxamide ribotide
name: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide [ChEBI:18406]
name: 5'-Phospho-ribosyl-5-amino-4-imidazole carboxamide
name: 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
name: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
name: AICAR
name: 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide
xref: UnificationXref5061

5'-Phosphoribosylformylglycinamidine
type: SmallMoleculeReference
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
name: 1-(5'-Phosphoribosyl)-N-formylglycinamidine
name: 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
name: 5'-Phosphoribosylformylglycinamidine [ChEBI:18413]
name: 5'-Phosphoribosyl-N-formylglycinamidine
xref: UnificationXref5043

Sec13p:Sec31p Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry471
component stoichiometry: Stoichiometry472
component: Protein579
component: Protein578
xref: UnificationXref1814
cellular location: GO:0005789
comment: Reactome DB_ID: 3669935

Sar1b:GTP:Sec23p:Sec24p:Sec13p:Sec31p Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry473
component stoichiometry: Stoichiometry474
component: Sar1b:GTP:Sec23p:Sec24p (name copied from entity in Homo sapiens)
component: Sec13p:Sec31p Complex (name copied from entity in Homo sapiens)
xref: UnificationXref1815
cellular location: GO:0005789
comment: Reactome DB_ID: 3669936

Arf1-GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry482
component stoichiometry: Stoichiometry483
component: Protein592
component: SmallMolecule78
xref: UnificationXref1849
cellular location: GO:0000139
comment: Reactome DB_ID: 3669696

Sec13p:Sec31p Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry480
component stoichiometry: Stoichiometry479
component: Protein590
component: Protein591
xref: UnificationXref1833
cellular location: GO:0012507
comment: Reactome DB_ID: 3669939

Sec23p:Sec24p Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry476
component stoichiometry: Stoichiometry477
component: PhysicalEntity63
component: Protein589
xref: UnificationXref1830
cellular location: GO:0012507
comment: Reactome DB_ID: 3669950

Sar1b:Sec23p:Sec24p:Sec13p:Sec31p Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry481
component stoichiometry: Stoichiometry478
component stoichiometry: Stoichiometry475
component: Protein580
component: Sec23p:Sec24p Complex (name copied from entity in Homo sapiens)
component: Sec13p:Sec31p Complex (name copied from entity in Homo sapiens)
xref: UnificationXref1834
cellular location: GO:0012507
comment: Reactome DB_ID: 3669952

http://identifiers.org/pubmed/15809071
type: PublicationXref
id: 15809071
author: Ishibashi, K
author: Uchida, S
author: Ko, SB
author: Sasaki, S
author: Kuwahara, M
author: Rai, T
author: Itoh, T
db: Pubmed
title: Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells
source: Biochem Biophys Res Commun 330:832-8
year: 2005

UnificationXref8719
type: UnificationXref
id: REACT_82878
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82878.9

Sar1b:GTP:Sec23p:Sec24p (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry468
component stoichiometry: Stoichiometry467
component: Sec23p:Sec24p Complex (name copied from entity in Homo sapiens)
component: Sar1b:GTP Complex (name copied from entity in Homo sapiens)
xref: UnificationXref1798
cellular location: GO:0005789
comment: Reactome DB_ID: 3669911

UnificationXref8718
type: UnificationXref
id: 3673322
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673322

Sec23p:Sec24p Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry466
component stoichiometry: Stoichiometry465
component: Protein566
component: PhysicalEntity62
xref: UnificationXref1797
cellular location: GO:0005789
comment: Reactome DB_ID: 3669910

Sec23p:Sec24p Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry462
component stoichiometry: Stoichiometry461
component: PhysicalEntity61
component: Protein564
xref: UnificationXref1783
cellular location: GO:0005829
comment: Reactome DB_ID: 3669924

Sar1b:GTP Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry464
component stoichiometry: Stoichiometry463
component: SmallMolecule77
component: Protein565
xref: UnificationXref1786
cellular location: GO:0005789
comment: Reactome DB_ID: 3669887

UnificationXref8715
type: UnificationXref
id: REACT_31869
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31869.10

UnificationXref8714
type: UnificationXref
id: 3673310
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673310

UnificationXref8717
type: UnificationXref
id: REACT_103798
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103798.9

Sar1b:GDP Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry469
component stoichiometry: Stoichiometry470
component: Protein575
component: SmallMolecule78
xref: UnificationXref1805
cellular location: GO:0005829
comment: Reactome DB_ID: 3669913

UnificationXref8716
type: UnificationXref
id: 3673311
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673311

UnificationXref8711
type: UnificationXref
id: REACT_128839
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128839.5

UnificationXref8710
type: UnificationXref
id: 3673431
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673431

UnificationXref8713
type: UnificationXref
id: REACT_91506
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91506.9

UnificationXref8712
type: UnificationXref
id: 3673309
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673309

eIF4F (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry456
component stoichiometry: Stoichiometry455
component stoichiometry: Stoichiometry454
component: eIF4A subunits complex (name copied from entity in Homo sapiens)
component: PhysicalEntity59
component: Protein555
xref: UnificationXref1759
cellular location: GO:0005829
comment: Reactome DB_ID: 3667126

40S ribosomal complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry419
component stoichiometry: Stoichiometry432
component stoichiometry: Stoichiometry448
component stoichiometry: Stoichiometry422
component stoichiometry: Stoichiometry423
component stoichiometry: Stoichiometry426
component stoichiometry: Stoichiometry421
component stoichiometry: Stoichiometry436
component stoichiometry: Stoichiometry441
component stoichiometry: Stoichiometry443
component stoichiometry: Stoichiometry425
component stoichiometry: Stoichiometry430
component stoichiometry: Stoichiometry429
component stoichiometry: Stoichiometry440
component stoichiometry: Stoichiometry420
component stoichiometry: Stoichiometry416
component stoichiometry: Stoichiometry417
component stoichiometry: Stoichiometry431
component stoichiometry: Stoichiometry433
component stoichiometry: Stoichiometry434
component stoichiometry: Stoichiometry418
component stoichiometry: Stoichiometry439
component stoichiometry: Stoichiometry445
component stoichiometry: Stoichiometry427
component stoichiometry: Stoichiometry435
component stoichiometry: Stoichiometry438
component stoichiometry: Stoichiometry444
component stoichiometry: Stoichiometry424
component stoichiometry: Stoichiometry428
component stoichiometry: Stoichiometry446
component stoichiometry: Stoichiometry442
component stoichiometry: Stoichiometry437
component stoichiometry: Stoichiometry447
component: PhysicalEntity57
component: Protein503
component: Protein487
component: Protein539
component: Protein530
component: Protein520
component: Protein536
component: Protein540
component: Protein526
component: Protein493
component: Protein486
component: Protein480
component: PhysicalEntity55
component: Protein516
component: Protein517
component: Protein523
component: Protein500
component: Protein541
component: Protein544
component: Protein512
component: Protein550
component: Protein506
component: Protein494
component: Protein490
component: Protein533
component: Protein483
component: Protein513
component: Protein547
component: Protein497
component: PhysicalEntity56
component: Protein509
component: Protein527
component: Protein479
xref: UnificationXref1749
cellular location: GO:0005829
comment: Reactome DB_ID: 3667067

phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry459
component stoichiometry: Stoichiometry460
component: Complex95
component: Protein468
xref: UnificationXref1762
cellular location: GO:0005829
comment: Reactome DB_ID: 3668679

eIF4A subunits complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry452
component stoichiometry: Stoichiometry453
component: Protein554
component: Protein553
xref: UnificationXref1755
cellular location: GO:0005829
comment: Reactome DB_ID: 3667120

eIF3 subunits complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry414
component stoichiometry: Stoichiometry410
component stoichiometry: Stoichiometry406
component stoichiometry: Stoichiometry408
component stoichiometry: Stoichiometry412
component stoichiometry: Stoichiometry404
component stoichiometry: Stoichiometry413
component stoichiometry: Stoichiometry411
component stoichiometry: Stoichiometry409
component stoichiometry: Stoichiometry407
component stoichiometry: Stoichiometry405
component: PhysicalEntity49
component: PhysicalEntity53
component: PhysicalEntity54
component: Protein477
component: PhysicalEntity52
component: Protein476
component: Protein474
component: PhysicalEntity50
component: Protein478
component: Protein475
component: PhysicalEntity51
xref: UnificationXref1620
cellular location: GO:0005829
comment: Reactome DB_ID: 3667094

UnificationXref8706
type: UnificationXref
id: 3673429
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673429

http://identifiers.org/pubmed/17996737
type: PublicationXref
id: 17996737
author: Chacinska, A
author: Guiard, B
author: Milenkovic, D
author: Stojanovski, D
author: Müller, JM
author: Pfanner, N
db: Pubmed
title: The MIA system for protein import into the mitochondrial intermembrane space
source: Biochim Biophys Acta 1783:610-7
year: 2008

UnificationXref8705
type: UnificationXref
id: REACT_108631
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108631.9

UnificationXref8704
type: UnificationXref
id: 3673494
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673494

UnificationXref8703
type: UnificationXref
id: REACT_95084
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95084.9

UnificationXref8709
type: UnificationXref
id: REACT_105270
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105270.9

UnificationXref8708
type: UnificationXref
id: 3673430
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673430

UnificationXref8707
type: UnificationXref
id: REACT_135936
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135936.5

UnificationXref8702
type: UnificationXref
id: 3670668
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670668

UnificationXref8701
type: UnificationXref
id: 3670661
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670661

UnificationXref8700
type: UnificationXref
id: 3670660
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670660

http://identifiers.org/pubmed/15710388
type: PublicationXref
id: 15710388
author: Meller, N
author: Nishikimi, A
author: Schwartz, MA
author: Maruyama, M
author: Isobe, K
author: Uekawa, N
db: Pubmed
title: Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes
source: FEBS Lett 579:1039-46
year: 2005

http://identifiers.org/pubmed/18721752
type: PublicationXref
id: 18721752
author: Lane, WS
author: Kaushansky, A
author: MacBeath, G
author: Rush, J
author: Budnik, BA
author: Gordus, A
db: Pubmed
title: System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties
source: Chem Biol 15:808-17
year: 2008

http://identifiers.org/pubmed/20494131
type: PublicationXref
id: 20494131
author: Welin, M
author: Nordlund, P
db: Pubmed
title: Understanding specificity in metabolic pathways--structural biology of human nucleotide metabolism
source: Biochem Biophys Res Commun 396:157-63
year: 2010

http://identifiers.org/pubmed/8682206
type: PublicationXref
id: 8682206
author: Authier, F
author: Bergeron, JJ
author: Posner, BI
db: Pubmed
title: Endosomal proteolysis of internalized proteins.
source: FEBS Lett 389:55-60
year: 1996

UnificationXref1698
type: UnificationXref
id: 3666840
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666840

UnificationXref1699
type: UnificationXref
id: P46784
db: UniProt

UnificationXref1696
type: UnificationXref
id: 3666854
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666854

UnificationXref1697
type: UnificationXref
id: Q08745
db: UniProt

UniProt:P38687
type: ProteinReference
xref: UnificationXref7769
organism: BioSource1

http://identifiers.org/pubmed/17567461
type: PublicationXref
id: 17567461
author: Lemasters, JJ
db: Pubmed
title: Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism
source: J Gastroenterol Hepatol 22:S31-7
year: 2007

UnificationXref1690
type: UnificationXref
id: 3666902
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666902

UnificationXref1691
type: UnificationXref
id: 3666903
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666903

UniProt:P38688
type: ProteinReference
xref: UnificationXref7774
organism: BioSource1

UniProt:P38689
type: ProteinReference
xref: UnificationXref3058
organism: BioSource1

UnificationXref1694
type: UnificationXref
id: P0CX47
db: UniProt

UnificationXref1695
type: UnificationXref
id: 3666853
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666853

UnificationXref1692
type: UnificationXref
id: P0CX48
db: UniProt

UnificationXref1693
type: UnificationXref
id: 3666851
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666851

UnificationXref1685
type: UnificationXref
id: 3666985
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666985

UnificationXref1686
type: UnificationXref
id: 3666967
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666967

UnificationXref1687
type: UnificationXref
id: P07281
db: UniProt

UnificationXref1688
type: UnificationXref
id: 3666898
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666898

UnificationXref1689
type: UnificationXref
id: P07280
db: UniProt

UniProt:P38697
type: ProteinReference
xref: UnificationXref5093
organism: BioSource1

UniProt:P32190
type: ProteinReference
xref: UnificationXref3363
organism: BioSource1

Facilitative Na+-independent glucose transporters
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction134
pathway component: BiochemicalReaction692
pathway component: REACT 159142.3
evidence: Evidence1067
xref: UnificationXref8174
xref: UnificationXref8175
pathway order: PathwayStep1071
pathway order: PathwayStep1074
pathway order: PathwayStep266
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:P32191
type: ProteinReference
xref: UnificationXref3449
organism: BioSource1

UnificationXref1680
type: UnificationXref
id: 3666908
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666908

UnificationXref1681
type: UnificationXref
id: P41058
db: UniProt

UnificationXref1682
type: UnificationXref
id: 3666980
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666980

UnificationXref1683
type: UnificationXref
id: P41057
db: UniProt

http://identifiers.org/pubmed/3594573
type: PublicationXref
id: 3594573
author: Rothman, JE
author: Gleason, ML
author: Serafini, TA
author: Wieland, FT
db: Pubmed
title: The rate of bulk flow from the endoplasmic reticulum to the cell surface
source: Cell 50:289-300
year: 1987

UnificationXref1684
type: UnificationXref
id: 3666984
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666984

UnificationXref1678
type: UnificationXref
id: 3667065
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667065

UnificationXref1679
type: UnificationXref
id: P25443
db: UniProt

UnificationXref1676
type: UnificationXref
id: P46654
db: UniProt

UnificationXref1677
type: UnificationXref
id: 3667064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667064

UnificationXref1674
type: UnificationXref
id: P32905
db: UniProt

UnificationXref1675
type: UnificationXref
id: 3667060
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667060

UnificationXref1672
type: UnificationXref
id: 3666938
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666938

UnificationXref1673
type: UnificationXref
id: 3666939
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666939

http://identifiers.org/pubmed/19531029
type: PublicationXref
id: 19531029
author: Kawamukai, Makoto
db: Pubmed
title: Biosynthesis and bioproduction of coenzyme Q10 by yeasts and other organisms
source: Biotechnol. Appl. Biochem. 53:217-26
year: 2009

UnificationXref1670
type: UnificationXref
id: 3666936
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666936

Mg++
type: SmallMoleculeReference
name: Magnesium [ChEBI:18420]
name: Mg2+
name: Magnesium
xref: UnificationXref2269

UnificationXref1671
type: UnificationXref
id: P0CX31
db: UniProt

http://identifiers.org/pubmed/15102545
type: PublicationXref
id: 15102545
author: Lewis, DF
db: Pubmed
title: 57 varieties: the human cytochromes P450
source: Pharmacogenomics 5:305-18
year: 2004

UniProt:Q02554
type: ProteinReference
xref: UnificationXref2454
organism: BioSource1

Synthesis of PIPs at the plasma membrane
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction337
pathway component: BiochemicalReaction335
pathway component: BiochemicalReaction334
pathway component: BiochemicalReaction333
pathway component: BiochemicalReaction336
pathway component: BiochemicalReaction332
evidence: Evidence538
xref: UnificationXref4389
xref: RelationshipXref405
xref: UnificationXref4390
pathway order: PathwayStep535
pathway order: PathwayStep533
pathway order: PathwayStep530
pathway order: PathwayStep531
pathway order: PathwayStep532
pathway order: PathwayStep534
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Regulation of Water Balance by Renal Aquaporins
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction94
pathway component: BiochemicalReaction715
evidence: Evidence1099
xref: UnificationXref8374
xref: UnificationXref8373
xref: RelationshipXref1033
pathway order: PathwayStep185
pathway order: PathwayStep1106
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1667
type: UnificationXref
id: 3667015
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667015

UnificationXref1668
type: UnificationXref
id: 3667016
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667016

UnificationXref1669
type: UnificationXref
id: P0CX32
db: UniProt

UnificationXref1663
type: UnificationXref
id: 3666885
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666885

UnificationXref1664
type: UnificationXref
id: P0CX35
db: UniProt

UnificationXref1665
type: UnificationXref
id: 3667013
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667013

UnificationXref1666
type: UnificationXref
id: P0CX36
db: UniProt

UnificationXref1660
type: UnificationXref
id: 3666880
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666880

UnificationXref1661
type: UnificationXref
id: P14127
db: UniProt

http://identifiers.org/pubmed/16141215
type: PublicationXref
id: 16141215
author: Hutson, SM
author: Conway, ME
author: Goto, M
author: Islam, MM
author: Miyahara, I
author: Hirotsu, K
author: Yennawar, NH
db: Pubmed
title: Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin
source: J Biol Chem 280:37246-56
year: 2005

UnificationXref1662
type: UnificationXref
id: 3666884
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666884

MLCL
type: SmallMoleculeReference
name: lysoDPG
name: Monolysocardiolipin
name: monolyso cardiolipin [ChEBI:60430]
name: monolysoDPG
name: monolyso cardiolipin
xref: UnificationXref4261

http://identifiers.org/pubmed/3539386
type: PublicationXref
id: 3539386
author: Wood, T
db: Pubmed
title: Physiological functions of the pentose phosphate pathway
source: Cell Biochem Funct 4:241-7
year: 1986

Folding of actin by CCT/TriC
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction806
evidence: Evidence1358
xref: UnificationXref9374
xref: RelationshipXref1134
xref: UnificationXref9373
pathway order: PathwayStep1359
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10798271
type: PublicationXref
id: 10798271
author: Heindl, B
author: Zahler, S
author: Kupatt, C
author: Becker, BF
db: Pubmed
title: Endothelial function and hemostasis
source: Z Kardiol 89:160-7
year: 2000

UnificationXref1651
type: UnificationXref
id: P0CX29
db: UniProt

UnificationXref1650
type: UnificationXref
id: 3666927
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666927

UnificationXref1655
type: UnificationXref
id: 3667051
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667051

UnificationXref1654
type: UnificationXref
id: O13516
db: UniProt

UnificationXref1653
type: UnificationXref
id: 3666930
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666930

UnificationXref1652
type: UnificationXref
id: 3666929
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666929

UnificationXref1659
type: UnificationXref
id: P02407
db: UniProt

UnificationXref1658
type: UnificationXref
id: 3667056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667056

UnificationXref1657
type: UnificationXref
id: 3667055
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667055

UnificationXref1656
type: UnificationXref
id: P05755
db: UniProt

UnificationXref1649
type: UnificationXref
id: P0CX30
db: UniProt

Cell Cycle
type: Pathway
data source: Provenance1
pathway component: REACT 90690.9
pathway component: REACT 108233.9
pathway component: REACT 102445.9
evidence: Evidence155
xref: UnificationXref1403
xref: UnificationXref1402
pathway order: PathwayStep141
pathway order: PathwayStep159
pathway order: PathwayStep83
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8799
type: UnificationXref
id: 3668439
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668439

UnificationXref8798
type: UnificationXref
id: REACT_2927
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2927.1

UnificationXref8797
type: UnificationXref
id: 110178
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110178

UnificationXref8796
type: UnificationXref
id: 3668438
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668438

UnificationXref8795
type: UnificationXref
id: 3668437
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668437

UnificationXref8794
type: UnificationXref
id: Q08214
db: UniProt

post exon ligation complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry718
component stoichiometry: Stoichiometry717
component stoichiometry: Stoichiometry715
component stoichiometry: Stoichiometry713
component stoichiometry: Stoichiometry714
component stoichiometry: Stoichiometry716
component: PhysicalEntity94
component: PhysicalEntity89
component: PhysicalEntity81
component: PhysicalEntity82
component: PhysicalEntity87
component: capped, methylated pre-mRNA:CBC Complex (name copied from entity in Homo sapiens)
xref: UnificationXref2506
cellular location: GO:0005654
comment: Reactome DB_ID: 3668074

ATAC C Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry708
component stoichiometry: Stoichiometry706
component stoichiometry: Stoichiometry712
component stoichiometry: Stoichiometry705
component stoichiometry: Stoichiometry707
component stoichiometry: Stoichiometry709
component stoichiometry: Stoichiometry711
component stoichiometry: Stoichiometry704
component stoichiometry: Stoichiometry710
component: U5 snRNP (name copied from entity in Homo sapiens)
component: U11 snRNP (name copied from entity in Homo sapiens)
component: U6 ATAC snRNP (name copied from entity in Homo sapiens)
component: PhysicalEntity89
component: U12 snRNP (name copied from entity in Homo sapiens)
component: PhysicalEntity81
component: PhysicalEntity82
component: PhysicalEntity87
component: capped, methylated pre-mRNA:CBC Complex (name copied from entity in Homo sapiens)
xref: UnificationXref2499
cellular location: GO:0005654
comment: Reactome DB_ID: 3668070

GLUT1, GLUT2, GLUT3, GLUT4
type: Complex
data source: Provenance1
member physical entity: GLUT4 tetramer (name copied from entity in Homo sapiens)
member physical entity: GLUT2 tetramer (name copied from entity in Homo sapiens)
member physical entity: GLUT1 tetramer (name copied from entity in Homo sapiens)
member physical entity: GLUT3 tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref2561
cellular location: GO:0005886
display name: GLUT tetramers
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3666089

GLUT2 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry719
component: Protein747
xref: UnificationXref2546
cellular location: GO:0005886
comment: Reactome DB_ID: 3666080

GLUT3 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry721
component: Protein753
xref: UnificationXref2556
cellular location: GO:0005886
comment: Reactome DB_ID: 3666084

UnificationXref1640
type: UnificationXref
id: 3667037
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667037

GLUT1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry720
component: Protein750
xref: UnificationXref2552
cellular location: GO:0005886
comment: Reactome DB_ID: 3666076

GLUT1:ATP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry724
component stoichiometry: Stoichiometry725
component: GLUT1 tetramer (name copied from entity in Homo sapiens)
component: SmallMolecule126
xref: UnificationXref2568
cellular location: GO:0005886
comment: Reactome DB_ID: 3671158

UnificationXref1642
type: UnificationXref
id: P39939
db: UniProt

http://identifiers.org/pubmed/10851172
type: PublicationXref
id: 10851172
author: Miller, FD
author: Kaplan, DR
db: Pubmed
title: Neurotrophin signal transduction in the nervous system
source: Curr Opin Neurobiol 10:381-91
year: 2000

GLUT4 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry722
component: Protein756
xref: UnificationXref2560
cellular location: GO:0005886
comment: Reactome DB_ID: 3666088

UnificationXref1641
type: UnificationXref
id: 3667038
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667038

phosphofructokinase tetramer
type: Complex
data source: Provenance1
member physical entity: phosphofructokinase, P2L2 complex (name copied from entity in Homo sapiens)
member physical entity: phosphofructokinase, P3L complex (name copied from entity in Homo sapiens)
member physical entity: phosphofructokinase, P4 complex (name copied from entity in Homo sapiens)
member physical entity: phosphofructokinase, PL3 complex (name copied from entity in Homo sapiens)
member physical entity: phosphofructokinase, L4 complex (name copied from entity in Homo sapiens)
xref: UnificationXref2635
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3666147

UnificationXref1644
type: UnificationXref
id: P39938
db: UniProt

glucose 6-phosphate isomerase dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry727
component: Protein779
xref: UnificationXref2616
cellular location: GO:0005829
comment: Reactome DB_ID: 3666159

UnificationXref1643
type: UnificationXref
id: 3666952
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666952

UnificationXref1646
type: UnificationXref
id: 3666957
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666957

UnificationXref1645
type: UnificationXref
id: 3666956
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666956

UnificationXref1648
type: UnificationXref
id: 3666862
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666862

UnificationXref1647
type: UnificationXref
id: P05756
db: UniProt

UnificationXref1638
type: UnificationXref
id: 3667033
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667033

UnificationXref1639
type: UnificationXref
id: P26786
db: UniProt

UnificationXref8784
type: UnificationXref
id: 110228
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110228

http://identifiers.org/pubmed/15509595
type: PublicationXref
id: 15509595
author: Elsässer, Hans-Peter
author: Mühlenhoff, Ulrich
author: Stehling, Oliver
author: Lill, R
author: Brückel, Bernd
db: Pubmed
title: Iron-sulfur protein maturation in human cells: evidence for a function of frataxin
source: Hum. Mol. Genet. 13:3007-15
year: 2004

UnificationXref8783
type: UnificationXref
id: CHEBI:35877
db: ChEBI

UnificationXref8786
type: UnificationXref
id: 3668464
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668464

UnificationXref8785
type: UnificationXref
id: REACT_4993
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4993.2

UnificationXref8788
type: UnificationXref
id: 3673298
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673298

UnificationXref8787
type: UnificationXref
id: REACT_88552
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88552.9

UnificationXref8789
type: UnificationXref
id: REACT_34478
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34478.10

U4 ATAC:U5:U6 ATAC Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry689
component stoichiometry: Stoichiometry701
component: U5 snRNP (name copied from entity in Homo sapiens)
component: U4 ATAC snRNP:U6 ATAC snRNP (name copied from entity in Homo sapiens)
xref: UnificationXref2495
cellular location: GO:0005654
comment: Reactome DB_ID: 3668068

U11 snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry678
component stoichiometry: Stoichiometry679
component: PhysicalEntity88
component: snRNP Sm core complex (name copied from entity in Homo sapiens)
xref: UnificationXref2466
cellular location: GO:0005654
comment: Reactome DB_ID: 3668007

SF3B (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry668
component stoichiometry: Stoichiometry672
component stoichiometry: Stoichiometry670
component stoichiometry: Stoichiometry671
component stoichiometry: Stoichiometry669
component: PhysicalEntity83
component: PhysicalEntity84
component: Protein733
component: Protein734
component: Protein735
xref: UnificationXref2458
cellular location: GO:0005654
comment: Reactome DB_ID: 3668026

snRNP Sm core complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry662
component stoichiometry: Stoichiometry665
component stoichiometry: Stoichiometry664
component stoichiometry: Stoichiometry663
component stoichiometry: Stoichiometry661
component stoichiometry: Stoichiometry660
component stoichiometry: Stoichiometry666
component: Protein727
component: Protein726
component: Protein731
component: Protein729
component: Protein728
component: Protein732
component: Protein730
xref: UnificationXref2449
cellular location: GO:0005654
comment: Reactome DB_ID: 3668006

UnificationXref8790
type: UnificationXref
id: 3673297
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673297

U12 snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry667
component stoichiometry: Stoichiometry675
component stoichiometry: Stoichiometry673
component stoichiometry: Stoichiometry674
component: PhysicalEntity86
component: PhysicalEntity85
component: SF3B (name copied from entity in Homo sapiens)
component: snRNP Sm core complex (name copied from entity in Homo sapiens)
xref: UnificationXref2462
cellular location: GO:0005654
comment: Reactome DB_ID: 3668028

UnificationXref8791
type: UnificationXref
id: REACT_108230
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108230.9

UnificationXref8792
type: UnificationXref
id: P31378
db: UniProt

UnificationXref8793
type: UnificationXref
id: 3668433
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668433

http://identifiers.org/pubmed/18678926
type: PublicationXref
id: 18678926
author: Rajnarayanan, RV
author: Cohly, HH
author: Isokpehi, R
db: Pubmed
title: Compartmentalization of aquaporins in the human intestine
source: Int J Environ Res Public Health 5:115-9
year: 2008

UnificationXref1637
type: UnificationXref
id: P48164
db: UniProt

UnificationXref1636
type: UnificationXref
id: 3666904
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666904

UnificationXref1635
type: UnificationXref
id: 3667020
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667020

ATAC B Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry702
component stoichiometry: Stoichiometry703
component: ATAC A Complex (name copied from entity in Homo sapiens)
component: U4 ATAC:U5:U6 ATAC Complex (name copied from entity in Homo sapiens)
xref: UnificationXref2496
cellular location: GO:0005654
comment: Reactome DB_ID: 3668069

UnificationXref1634
type: UnificationXref
id: P26783
db: UniProt

U5 snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry698
component stoichiometry: Stoichiometry690
component stoichiometry: Stoichiometry694
component stoichiometry: Stoichiometry691
component stoichiometry: Stoichiometry696
component stoichiometry: Stoichiometry693
component stoichiometry: Stoichiometry697
component stoichiometry: Stoichiometry699
component stoichiometry: Stoichiometry700
component stoichiometry: Stoichiometry695
component stoichiometry: Stoichiometry692
component: Protein742
component: Protein736
component: Protein738
component: Protein741
component: Protein739
component: Protein737
component: Protein743
component: PhysicalEntity93
component: Protein740
component: PhysicalEntity92
component: snRNP Sm core complex (name copied from entity in Homo sapiens)
xref: UnificationXref2494
cellular location: GO:0005654
comment: Reactome DB_ID: 3668064

UnificationXref1633
type: UnificationXref
id: 3666976
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666976

U4 ATAC snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry686
component stoichiometry: Stoichiometry687
component: PhysicalEntity91
component: snRNP Sm core complex (name copied from entity in Homo sapiens)
xref: UnificationXref2474
cellular location: GO:0005654
comment: Reactome DB_ID: 3668065

UnificationXref1632
type: UnificationXref
id: 3666975
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666975

U6 ATAC snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry684
component stoichiometry: Stoichiometry683
component: PhysicalEntity90
component: snRNP Sm core complex (name copied from entity in Homo sapiens)
xref: UnificationXref2471
cellular location: GO:0005654
comment: Reactome DB_ID: 3668066

UnificationXref1631
type: UnificationXref
id: Q3E7X9
db: UniProt

U4 ATAC snRNP:U6 ATAC snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry685
component stoichiometry: Stoichiometry688
component: U4 ATAC snRNP (name copied from entity in Homo sapiens)
component: U6 ATAC snRNP (name copied from entity in Homo sapiens)
xref: UnificationXref2475
cellular location: GO:0005654
comment: Reactome DB_ID: 3668067

UnificationXref1630
type: UnificationXref
id: 3666971
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666971

UnificationXref1627
type: UnificationXref
id: 3667007
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667007

UnificationXref1628
type: UnificationXref
id: 3666863
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666863

UnificationXref1629
type: UnificationXref
id: P0C0X0
db: UniProt

UnificationXref8775
type: UnificationXref
id: CHEBI:44605
db: ChEBI

UniProt:Q02516
type: ProteinReference
xref: UnificationXref3458
organism: BioSource1

UnificationXref8774
type: UnificationXref
id: REACT_141027
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141027.5

UnificationXref8773
type: UnificationXref
id: 3673296
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673296

UnificationXref8772
type: UnificationXref
id: REACT_90676
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90676.9

UnificationXref8779
type: UnificationXref
id: REACT_2655
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2655.1

UnificationXref8778
type: UnificationXref
id: 110187
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110187

UnificationXref8777
type: UnificationXref
id: REACT_4681
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4681.2

UnificationXref8776
type: UnificationXref
id: 110242
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110242

ADAR2 homodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry632
component: Protein723
xref: UnificationXref2396
cellular location: GO:0005654
comment: Reactome DB_ID: 3668291

Editosome (ADAR1) complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry630
component stoichiometry: Stoichiometry629
component: PhysicalEntity77
component: ADAR1 homodimer (name copied from entity in Homo sapiens)
xref: UnificationXref2392
cellular location: GO:0005654
comment: Reactome DB_ID: 3668081

A to I edited RNA:Editosome (ADAR1) complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry636
component stoichiometry: Stoichiometry635
component: PhysicalEntity78
component: ADAR1 homodimer (name copied from entity in Homo sapiens)
xref: UnificationXref2406
cellular location: GO:0005654
comment: Reactome DB_ID: 3668294

Editosome (ADAR2) complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry634
component stoichiometry: Stoichiometry633
component: PhysicalEntity77
component: ADAR2 homodimer (name copied from entity in Homo sapiens)
xref: UnificationXref2398
cellular location: GO:0005654
comment: Reactome DB_ID: 3668292

UnificationXref8781
type: UnificationXref
id: 3668463
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668463

G-protein mediated events
type: Pathway
data source: Provenance1
pathway component: REACT 31869.10
evidence: Evidence1182
xref: UnificationXref8717
xref: UnificationXref8716
pathway order: PathwayStep1188
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8782
type: UnificationXref
id: REACT_28730
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28730.10

UnificationXref8780
type: UnificationXref
id: 3668461
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668461

ATAC A Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry680
component stoichiometry: Stoichiometry677
component stoichiometry: Stoichiometry682
component stoichiometry: Stoichiometry659
component stoichiometry: Stoichiometry676
component stoichiometry: Stoichiometry658
component stoichiometry: Stoichiometry681
component: U11 snRNP (name copied from entity in Homo sapiens)
component: PhysicalEntity89
component: U12 snRNP (name copied from entity in Homo sapiens)
component: PhysicalEntity81
component: PhysicalEntity82
component: PhysicalEntity87
component: capped, methylated pre-mRNA:CBC Complex (name copied from entity in Homo sapiens)
xref: UnificationXref2468
cellular location: GO:0005654
comment: Reactome DB_ID: 3668029

UnificationXref1624
type: UnificationXref
id: 3667002
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667002

mRNA (N6-adenosine)-methyltransferase (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry656
component stoichiometry: Stoichiometry657
component: PhysicalEntity80
component: Protein725
xref: UnificationXref2429
cellular location: GO:0005654
comment: Reactome DB_ID: 3666821

UnificationXref1623
type: UnificationXref
id: P33442
db: UniProt

UnificationXref1626
type: UnificationXref
id: 3667006
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667006

UnificationXref1625
type: UnificationXref
id: P23248
db: UniProt

capped, methylated pre-mRNA:CBC Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry654
component stoichiometry: Stoichiometry653
component stoichiometry: Stoichiometry655
component: PhysicalEntity79
component: RNA Polymerase II (unphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: Cap Binding Complex (CBC) (name copied from entity in Homo sapiens)
xref: UnificationXref2425
cellular location: GO:0005654
comment: Reactome DB_ID: 3666815

UnificationXref1620
type: UnificationXref
id: 3667094
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667094

A to I edited RNA:Editosome (ADAR2) complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry638
component stoichiometry: Stoichiometry637
component: PhysicalEntity78
component: ADAR2 homodimer (name copied from entity in Homo sapiens)
xref: UnificationXref2412
cellular location: GO:0005654
comment: Reactome DB_ID: 3668297

RNA Polymerase II holoenzyme complex (unphosphorylated) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry650
component stoichiometry: Stoichiometry649
component stoichiometry: Stoichiometry641
component stoichiometry: Stoichiometry643
component stoichiometry: Stoichiometry640
component stoichiometry: Stoichiometry648
component stoichiometry: Stoichiometry642
component stoichiometry: Stoichiometry639
component stoichiometry: Stoichiometry644
component stoichiometry: Stoichiometry645
component stoichiometry: Stoichiometry647
component stoichiometry: Stoichiometry646
component: Protein712
component: Protein714
component: Protein709
component: Protein707
component: Protein716
component: Protein710
component: Protein711
component: Protein708
component: Protein713
component: Protein715
component: PhysicalEntity70
component: Protein724
xref: UnificationXref2421
cellular location: GO:0005654
comment: Reactome DB_ID: 3666813

UnificationXref1622
type: UnificationXref
id: 3666989
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666989

RNA Polymerase II (unphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry652
component stoichiometry: Stoichiometry651
component: TFIIF (name copied from entity in Homo sapiens)
component: RNA Polymerase II holoenzyme complex (unphosphorylated) (name copied from entity in Homo sapiens)
xref: UnificationXref2422
cellular location: GO:0005654
comment: Reactome DB_ID: 3666814

UnificationXref1621
type: UnificationXref
id: P05750
db: UniProt

UnificationXref1603
type: UnificationXref
id: 3667095
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667095

UnificationXref1604
type: UnificationXref
id: 3667092
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667092

UnificationXref1601
type: UnificationXref
id: 3667109
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667109

UnificationXref1602
type: UnificationXref
id: 3667110
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667110

UnificationXref1600
type: UnificationXref
id: 3667108
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667108

http://identifiers.org/pubmed/9089413
type: PublicationXref
id: 9089413
author: Miyazawa, S
author: Souri, M
author: Jiang, LL
author: Hashimoto, T
db: Pubmed
title: Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein
source: J Biochem 121:364-9
year: 1997

http://identifiers.org/pubmed/10518211
type: PublicationXref
id: 10518211
author: Tartaglia, LA
author: Patel, S
author: Lodish, HF
author: Watson, N
author: Gimeno, RE
author: Ge, P
author: Kotler, M
author: Raimondi, A
author: Hirsch, DJ
author: Stahl, A
author: Punreddy, S
db: Pubmed
title: Identification of the major intestinal fatty acid transport protein
source: Mol Cell 4:299-308
year: 1999

UnificationXref1609
type: UnificationXref
id: 3667093
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667093

UnificationXref1608
type: UnificationXref
id: 3667085
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667085

UnificationXref1607
type: UnificationXref
id: 3667071
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667071

UnificationXref1606
type: UnificationXref
id: Q05775
db: UniProt

UnificationXref1605
type: UnificationXref
id: 3667086
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667086

UnificationXref1612
type: UnificationXref
id: Q04067
db: UniProt

phosphorylated residue
type: SequenceModificationVocabulary
xref: UnificationXref1141

UnificationXref1613
type: UnificationXref
id: 3667079
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667079

UnificationXref1614
type: UnificationXref
id: P40217
db: UniProt

UnificationXref1615
type: UnificationXref
id: 3667075
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667075

UnificationXref1610
type: UnificationXref
id: P06103
db: UniProt

UnificationXref1611
type: UnificationXref
id: 3667084
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667084

http://identifiers.org/pubmed/12853463
type: PublicationXref
id: 12853463
author: Nagai, K
author: Menichelli, E
author: Kuglstatter, A
author: Isel, C
author: Oubridge, C
author: Jovine, L
db: Pubmed
title: Structure, function and evolution of the signal recognition particle
source: EMBO J 22:3479-85
year: 2003

UniProt:P28817
type: ProteinReference
xref: UnificationXref5920
organism: BioSource1

http://identifiers.org/pubmed/12686127
type: PublicationXref
id: 12686127
author: Hillary, RA
author: Pegg, AE
db: Pubmed
title: Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide
source: Biochim Biophys Acta 1647:161-6
year: 2003

Succinic semialdehyde
type: SmallMoleculeReference
name: Succinate semialdehyde
name: ChEBI:16265 Succinate semialdehyde
xref: UnificationXref454

UDP-N-acetyl-D-glucosamine
type: SmallMoleculeReference
name: UDP-N-acetyl-D-glucosamine [ChEBI:16264]
xref: UnificationXref8313

Platelet homeostasis
type: Pathway
data source: Provenance1
pathway component: Nitric oxide stimulates guanylate cyclase
evidence: Evidence1002
xref: UnificationXref7843
xref: UnificationXref7842
pathway order: PathwayStep1013
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1617
type: UnificationXref
id: 3667091
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667091

UnificationXref1616
type: UnificationXref
id: P32497
db: UniProt

UnificationXref1619
type: UnificationXref
id: 3667080
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667080

UnificationXref1618
type: UnificationXref
id: 3667087
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667087

UnificationXref5984
type: UnificationXref
id: REACT_2619
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2619.2

UnificationXref5985
type: UnificationXref
id: 71185
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71185

UnificationXref5982
type: UnificationXref
id: CHEBI:18377
db: ChEBI

UnificationXref5983
type: UnificationXref
id: 33179
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=33179

UnificationXref5980
type: UnificationXref
id: 29500
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29500

UnificationXref5981
type: UnificationXref
id: REACT_3188
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3188.2

UnificationXref5988
type: UnificationXref
id: 3669660
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669660

UnificationXref5989
type: UnificationXref
id: 3669661
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669661

UnificationXref5986
type: UnificationXref
id: REACT_2784
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2784.3

UnificationXref5987
type: UnificationXref
id: P47125
db: UniProt

UnificationXref5993
type: UnificationXref
id: 3671478
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671478

UnificationXref5994
type: UnificationXref
id: 3671480
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671480

UnificationXref5995
type: UnificationXref
id: REACT_108462
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108462.9

UnificationXref5996
type: UnificationXref
id: 3671508
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671508

H2O2
type: SmallMoleculeReference
name: Hydrogen peroxide
name: H2O2 [ChEBI:16240]
xref: UnificationXref5221

PublicationXref1907
type: PublicationXref
author: Greene, E
author: Henikoff, S
title: Kinesin home page
url: http://www.cellbio.duke.edu/kinesin/

UnificationXref5990
type: UnificationXref
id: 3669663
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669663

UnificationXref5991
type: UnificationXref
id: REACT_143242
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143242.5

http://identifiers.org/pubmed/7917292
type: PublicationXref
id: 7917292
author: Furness, J
author: Doherty, P
author: Walsh, FS
author: Williams, EJ
db: Pubmed
title: Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin
source: Neuron 13:583-94
year: 1994

UnificationXref5992
type: UnificationXref
id: 3671477
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671477

4-Trimethylammoniobutanoate
type: SmallMoleculeReference
name: 4-Trimethylammoniobutanoate [ChEBI:16244]
xref: UnificationXref6092

YNL037C
type: ProteinReference
name: IDH1
name: UniProt:P28834 IDH1
name: N2690
xref: UnificationXref555
comment: FUNCTION Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.CATALYTIC ACTIVITY Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.ENZYME REGULATION Allosterically regulated by several compounds including AMP, NAD(+), and citrate.SUBUNIT Octamer of two non-identical subunits IDH1 and IDH2.MISCELLANEOUS Present with 10500 molecules/cell in log phase SD medium.SIMILARITY Belongs to the isocitrate and isopropylmalate dehydrogenases family.
organism: BioSource1

UnificationXref5997
type: UnificationXref
id: 3671509
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671509

http://identifiers.org/pubmed/16319170
type: PublicationXref
id: 16319170
author: Kiss, T
author: Jady, BE
author: Bertrand, E
author: Richard, P
db: Pubmed
title: Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres
source: Mol Biol Cell 17:944-54
year: 2006

UnificationXref5998
type: UnificationXref
id: 3671511
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671511

UnificationXref5999
type: UnificationXref
id: REACT_145698
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145698.5

UnificationXref5967
type: UnificationXref
id: REACT_139011
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139011.5

UnificationXref5966
type: UnificationXref
id: 3673540
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673540

UnificationXref5965
type: UnificationXref
id: REACT_135899
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135899.5

UnificationXref5964
type: UnificationXref
id: 3671488
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671488

UnificationXref5969
type: UnificationXref
id: 3666312
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666312

UnificationXref5968
type: UnificationXref
id: P09368
db: UniProt

http://identifiers.org/pubmed/11788603
type: PublicationXref
id: 11788603
author: Zhou, T
author: Tomchick, DR
author: Zhang, H
author: Marquez, VE
author: Osterman, AL
author: Binns, DD
author: Grishin, NV
author: Kurnasov, OV
db: Pubmed
title: Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
source: J Biol Chem 277:13148-54
year: 2002

UnificationXref5963
type: UnificationXref
id: REACT_25923
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25923.1

UnificationXref5962
type: UnificationXref
id: 893599
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=893599

UnificationXref5961
type: UnificationXref
id: CHEBI:29750
db: ChEBI

UnificationXref5960
type: UnificationXref
id: REACT_90594
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90594.9

UniProt:P32263
type: ProteinReference
xref: UnificationXref5821
organism: BioSource1

UnificationXref5976
type: UnificationXref
id: REACT_91287
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91287.9

PublicationXref1922
type: PublicationXref
author: Marder, V
author: George, J
author: Colman, R
author: Goldhaber, S
author: Clowes, A
title: Hemostasis and Thrombosis: Basic Principles and Clinical Practice
year: 2005

UnificationXref5975
type: UnificationXref
id: 3666321
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666321

PublicationXref1923
type: PublicationXref
author: Machin, S
author: Allford, S
title: Haemostasis
source: Surgery (Oxford) 22:200a - 200d
year: 2004

UnificationXref5978
type: UnificationXref
id: REACT_102504
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102504.9

UnificationXref5977
type: UnificationXref
id: 3673111
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673111

UnificationXref5979
type: UnificationXref
id: CHEBI:16828
db: ChEBI

http://identifiers.org/pubmed/17331979
type: PublicationXref
id: 17331979
author: Napoli, E
author: Cortopassi, G
author: Shan, Y
db: Pubmed
title: Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones
source: Hum Mol Genet 16:929-41
year: 2007

UnificationXref5970
type: UnificationXref
id: 3666314
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666314

UnificationXref5972
type: UnificationXref
id: P07275
db: UniProt

UnificationXref5971
type: UnificationXref
id: REACT_135816
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135816.5

UnificationXref5974
type: UnificationXref
id: 3666319
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666319

UnificationXref5973
type: UnificationXref
id: 3666318
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666318

http://identifiers.org/pubmed/8946909
type: PublicationXref
id: 8946909
author: Reinberg, D
author: Lagrange, T
author: Orphanides, G
db: Pubmed
title: The general transcription factors of RNA polymerase II.
source: Genes Dev 10:2657-83
year: 1997

UniProt:P22768
type: ProteinReference
xref: UnificationXref6064
organism: BioSource1

UnificationXref5949
type: UnificationXref
id: Q03028
db: UniProt

UnificationXref5948
type: UnificationXref
id: 3670294
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670294

UnificationXref5947
type: UnificationXref
id: Q99297
db: UniProt

UnificationXref5946
type: UnificationXref
id: REACT_2814
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2814.1

Glycolysis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction142
pathway component: BiochemicalReaction144
pathway component: BiochemicalReaction141
pathway component: BiochemicalReaction146
pathway component: BiochemicalReaction143
pathway component: BiochemicalReaction145
evidence: Evidence284
xref: RelationshipXref176
xref: UnificationXref2714
xref: UnificationXref2713
pathway order: PathwayStep281
pathway order: PathwayStep278
pathway order: PathwayStep279
pathway order: PathwayStep277
pathway order: PathwayStep280
pathway order: PathwayStep276
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref5945
type: UnificationXref
id: 70951
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70951

UnificationXref5944
type: UnificationXref
id: REACT_5045
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5045.1

UnificationXref5943
type: UnificationXref
id: 113577
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113577

UnificationXref5942
type: UnificationXref
id: CHEBI:15753
db: ChEBI

http://identifiers.org/pubmed/12118249
type: PublicationXref
id: 12118249
author: Kato, RM
author: Guo, B
author: Leitges, M
author: Kawakami, T
author: Humphries, LA
author: Patrone, L
author: Wall, R
author: Sommer, K
author: Kang, S
author: Kawakami, Y
author: Teitell, M
author: Su, TT
author: Chae, K
author: Rawlings, DJ
db: Pubmed
title: PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling
source: Nat Immunol 3:780-6
year: 2002

UnificationXref5941
type: UnificationXref
id: REACT_105621
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105621.9

ChEBI:16290 5alpha-cholesta-7,24-dien-3beta-ol
type: SmallMoleculeReference
name: 5alpha-cholesta-7,24-dien-3beta-ol
xref: UnificationXref3798

UnificationXref5940
type: UnificationXref
id: 3666372
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666372

http://identifiers.org/pubmed/18195088
type: PublicationXref
id: 18195088
author: Broer, Stefan
db: Pubmed
title: Amino acid transport across mammalian intestinal and renal epithelia
source: Physiol Rev 88:249-86
year: 2008

http://identifiers.org/pubmed/12853446
type: PublicationXref
id: 12853446
author: McCarthy, CC
author: Stringer, DK
author: Koeppel, MA
author: Jakobi, R
db: Pubmed
title: Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation
source: J Biol Chem 278:38675-85
year: 2003

http://identifiers.org/pubmed/18195086
type: PublicationXref
id: 18195086
author: Ashmore, J
db: Pubmed
title: Cochlear outer hair cell motility
source: Physiol Rev 88:173-210
year: 2008

http://identifiers.org/pubmed/7228857
type: PublicationXref
id: 7228857
author: Gaylor, JL
author: Grinstead, GF
author: Fukushima, H
db: Pubmed
title: Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase.
source: J Biol Chem 256:4822-6
year: 1981

UnificationXref5958
type: UnificationXref
id: REACT_89552
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89552.9

UnificationXref5957
type: UnificationXref
id: 3666456
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666456

UnificationXref5959
type: UnificationXref
id: 3673114
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673114

UnificationXref5954
type: UnificationXref
id: CHEBI:15524
db: ChEBI

UnificationXref5953
type: UnificationXref
id: REACT_88961
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88961.9

UnificationXref5956
type: UnificationXref
id: REACT_2558
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2558.2

UnificationXref5955
type: UnificationXref
id: 70955
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70955

UnificationXref5950
type: UnificationXref
id: 3670298
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670298

UniProt:P32288
type: ProteinReference
xref: UnificationXref518
organism: BioSource1

UnificationXref5952
type: UnificationXref
id: 3670301
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670301

UnificationXref5951
type: UnificationXref
id: 3670299
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670299

2'-deoxyadenosine 5'-triphosphate
type: SmallMoleculeReference
name: Deoxyadenosine 5'-triphosphate
name: dATP [ChEBI:16284]
name: dATP
name: Deoxyadenosine triphosphate
xref: UnificationXref1039

Phytanate
type: SmallMoleculeReference
name: Phytanate [ChEBI:8189]
name: Phytanic acid
xref: UnificationXref3512

http://identifiers.org/pubmed/2188967
type: PublicationXref
id: 2188967
author: Hackert, ML
author: Reed, LJ
db: Pubmed
title: Structure-function relationships in dihydrolipoamide acyltransferases.
source: J Biol Chem 265:8971-4
year: 1990

UniProt:Q07800
type: ProteinReference
xref: UnificationXref9831
organism: BioSource1

http://identifiers.org/pubmed/20457929
type: PublicationXref
id: 20457929
author: Walker, SS
author: Hasson, SA
author: Dabir, DV
author: Damoiseaux, R
author: Koehler, CM
author: Glavin, JD
db: Pubmed
title: Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation
source: Proc Natl Acad Sci U S A 107:9578-83
year: 2010

http://identifiers.org/pubmed/11001937
type: PublicationXref
id: 11001937
author: Francis, P
author: Berry, V
author: Wyatt, MK
author: Agre, P
author: Yasui, M
author: Bhattacharya, SS
author: Wistow, G
author: Moore, A
author: Chung, JJ
db: Pubmed
title: Functional impairment of lens aquaporin in two families with dominantly inherited cataracts
source: Hum Mol Genet 9:2329-34
year: 2000

http://identifiers.org/pubmed/15337521
type: PublicationXref
id: 15337521
author: Moens, U
author: Johannessen, M
author: Delghandi, MP
db: Pubmed
title: What turns CREB on?
source: Cell Signal 16:1211-27
year: 2004

UnificationXref5929
type: UnificationXref
id: CHEBI:16927
db: ChEBI

UnificationXref5928
type: UnificationXref
id: REACT_3737
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3737.2

http://identifiers.org/pubmed/12207013
type: PublicationXref
id: 12207013
author: Ma, Sheng
author: Jang, Young-Joo
author: Terada, Yasuhiko
author: Erikson, Raymond L
db: Pubmed
title: Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase
source: J. Biol. Chem. 277:44115-20
year: 2002

http://identifiers.org/pubmed/12145188
type: PublicationXref
id: 12145188
author: Hardt, B
author: Völker, C
author: Van Coster, RN
author: Breuer, W
author: Bause, E
author: De Praeter, CM
author: Kalz-Füller, B
db: Pubmed
title: Processing of N-linked carbohydrate chains in a patient with glucosidase I deficiency (CDG type IIb)
source: Glycobiology 12:473-83
year: 2002

UnificationXref5920
type: UnificationXref
id: P28817
db: UniProt

UnificationXref5921
type: UnificationXref
id: 3666361
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666361

UnificationXref5922
type: UnificationXref
id: 3666363
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666363

UnificationXref5923
type: UnificationXref
id: REACT_29772
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29772.10

UnificationXref5924
type: UnificationXref
id: 3673113
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673113

UnificationXref5925
type: UnificationXref
id: REACT_104316
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104316.9

UnificationXref5926
type: UnificationXref
id: CHEBI:18019
db: ChEBI

UnificationXref5927
type: UnificationXref
id: 29444
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29444

UnificationXref5939
type: UnificationXref
id: REACT_4347
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4347.2

http://identifiers.org/pubmed/17242360
type: PublicationXref
id: 17242360
author: Jackowski, S
author: Zhang, YM
author: Rock, CO
author: Leonardi, R
db: Pubmed
title: Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine
source: Proc Natl Acad Sci U S A 104:1494-9
year: 2007

UnificationXref8800
type: UnificationXref
id: 3668440
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668440

UnificationXref8801
type: UnificationXref
id: REACT_83953
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83953.9

UnificationXref8802
type: UnificationXref
id: 110180
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110180

UniProt:P30283
type: ProteinReference
xref: UnificationXref105
organism: BioSource1

UnificationXref8803
type: UnificationXref
id: REACT_5125
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5125.1

UnificationXref8804
type: UnificationXref
id: 3668443
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668443

UnificationXref8805
type: UnificationXref
id: 3668444
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668444

UnificationXref8806
type: UnificationXref
id: REACT_95247
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95247.9

UnificationXref8807
type: UnificationXref
id: 3668445
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668445

UnificationXref8808
type: UnificationXref
id: 3668446
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668446

UnificationXref8809
type: UnificationXref
id: REACT_86077
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86077.9

phosphofructokinase, P3L complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry731
component stoichiometry: Stoichiometry730
component: Protein783
component: Protein780
xref: UnificationXref2632
cellular location: GO:0005829
comment: Reactome DB_ID: 3666144

phosphofructokinase, P2L2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry733
component stoichiometry: Stoichiometry732
component: Protein783
component: Protein780
xref: UnificationXref2633
cellular location: GO:0005829
comment: Reactome DB_ID: 3666145

phosphofructokinase, L4 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry728
component: Protein780
xref: UnificationXref2627
cellular location: GO:0005829
comment: Reactome DB_ID: 3666139

phosphofructokinase, P4 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry729
component: Protein783
xref: UnificationXref2631
cellular location: GO:0005829
comment: Reactome DB_ID: 3666143

UnificationXref5930
type: UnificationXref
id: 30176
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30176

UnificationXref5933
type: UnificationXref
id: 3666367
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666367

UnificationXref5934
type: UnificationXref
id: 3666368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666368

UnificationXref5931
type: UnificationXref
id: REACT_3229
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3229.3

UnificationXref5932
type: UnificationXref
id: P38999
db: UniProt

UnificationXref5937
type: UnificationXref
id: CHEBI:17917
db: ChEBI

UnificationXref5938
type: UnificationXref
id: 113556
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113556

UnificationXref5935
type: UnificationXref
id: 3666370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666370

UnificationXref5936
type: UnificationXref
id: REACT_157283
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157283.3

UnificationXref5907
type: UnificationXref
id: CHEBI:15476
db: ChEBI

UnificationXref5906
type: UnificationXref
id: REACT_138778
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138778.5

UnificationXref5909
type: UnificationXref
id: REACT_2559
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2559.1

UnificationXref5908
type: UnificationXref
id: 70836
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70836

G alpha (s) signalling events
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction736
evidence: Evidence1173
xref: UnificationXref8696
xref: UnificationXref8695
pathway order: PathwayStep1179
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref5902
type: UnificationXref
id: 3666348
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666348

UnificationXref5903
type: UnificationXref
id: 3666350
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666350

UnificationXref5904
type: UnificationXref
id: REACT_97898
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97898.9

http://identifiers.org/pubmed/21102611
type: PublicationXref
id: 21102611
author: Gareau, Jaclyn R
author: Lima, Christopher D
db: Pubmed
title: The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition
source: Nat. Rev. Mol. Cell Biol. 11:861-71
year: 2010

UnificationXref5905
type: UnificationXref
id: 3671307
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671307

UnificationXref5900
type: UnificationXref
id: 3666346
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666346

UnificationXref5901
type: UnificationXref
id: 3666347
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666347

http://identifiers.org/pubmed/19513348
type: PublicationXref
id: 19513348
author: Szczepanowska, J
db: Pubmed
title: Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements
source: Acta Biochim Pol 56:225-34
year: 2009

UnificationXref5919
type: UnificationXref
id: REACT_22670
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22670.2

UnificationXref5918
type: UnificationXref
id: 573404
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=573404

UniProt:P02829
type: ProteinReference
xref: UnificationXref2106
organism: BioSource1

UnificationXref5917
type: UnificationXref
id: CHEBI:11805
db: ChEBI

UnificationXref5915
type: UnificationXref
id: 71847
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71847

UnificationXref5916
type: UnificationXref
id: REACT_2654
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2654.2

UnificationXref5913
type: UnificationXref
id: REACT_139577
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139577.5

UnificationXref5914
type: UnificationXref
id: CHEBI:28259
db: ChEBI

UnificationXref5911
type: UnificationXref
id: REACT_4883
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4883.1

UnificationXref5912
type: UnificationXref
id: 3666357
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666357

UnificationXref5910
type: UnificationXref
id: 70843
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70843

Pentose phosphate pathway (hexose monophosphate shunt)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction181
pathway component: BiochemicalReaction183
pathway component: BiochemicalReaction182
pathway component: BiochemicalReaction180
pathway component: BiochemicalReaction176
pathway component: BiochemicalReaction184
pathway component: BiochemicalReaction178
pathway component: BiochemicalReaction177
pathway component: BiochemicalReaction179
evidence: Evidence328
xref: UnificationXref3045
xref: RelationshipXref228
xref: UnificationXref3044
pathway order: PathwayStep320
pathway order: PathwayStep319
pathway order: PathwayStep318
pathway order: PathwayStep321
pathway order: PathwayStep322
pathway order: PathwayStep325
pathway order: PathwayStep323
pathway order: PathwayStep317
pathway order: PathwayStep324
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/14556004
type: PublicationXref
id: 14556004
author: Sato, S
author: Takeda, K
author: Takeuchi, O
author: Hoshino, K
author: Kaisho, T
author: Uematsu, S
author: Hemmi, H
author: Yamamoto, M
db: Pubmed
title: TRAM is specifically involved in the Toll-like receptor 4-mediated
source: Nat Immunol 4:1144-50
year: 2003

http://identifiers.org/pubmed/15945070
type: PublicationXref
id: 15945070
author: Neupert, C
author: Clarke, JT
author: Frank, CG
author: Hennet, T
author: Weinstein, M
author: Poplawski, N
author: Schollen, E
author: Seargeant, L
author: Aebi, M
author: Matthijs, G
author: Griffiths, A
author: Grubenmann, CE
db: Pubmed
title: CDG-IL: an infant with a novel mutation in the ALG9 gene and additional phenotypic features
source: Am J Med Genet A 136:194-7
year: 2005

http://identifiers.org/pubmed/11111075
type: PublicationXref
id: 11111075
author: Houten, SM
author: Waterham, HR
db: Pubmed
title: Biochemical and genetic aspects of mevalonate kinase and its deficiency
source: Biochim Biophys Acta 1529:19-32
year: 2000

FAD [ChEBI:16238]
type: SmallMoleculeReference
name: FAD
name: Flavin adenine dinucleotide
xref: UnificationXref3439

guanine
type: SmallMoleculeReference
name: guanine [ChEBI:16235]
name: 2-amino-6-hydroxypurine
xref: UnificationXref5165

Activation of Chaperone Genes by ATF6-alpha
type: Pathway
data source: Provenance1
pathway component: TemplateReaction14
evidence: Evidence1419
xref: UnificationXref9807
xref: UnificationXref9806
pathway order: PathwayStep1424
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:P38707
type: ProteinReference
xref: UnificationXref7269
organism: BioSource1

UniProt:P38709
type: ProteinReference
xref: UnificationXref2810
organism: BioSource1

http://identifiers.org/pubmed/10567352
type: PublicationXref
id: 10567352
author: Painter, GF
author: Cooke, FT
author: Holmes, AB
author: McEwen, RK
author: Ohya, Y
author: Shisheva, A
author: Michell, RH
author: Parker, PJ
author: Dove, SK
db: Pubmed
title: Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases
source: J Biol Chem 274:33905-12
year: 1999

UniProt:P38711
type: ProteinReference
xref: UnificationXref1739
organism: BioSource1

UniProt:P38710
type: ProteinReference
xref: UnificationXref3215
organism: BioSource1

UniProt:P38715
type: ProteinReference
xref: UnificationXref77
organism: BioSource1

http://identifiers.org/pubmed/3053703
type: PublicationXref
id: 3053703
author: Meister, A
db: Pubmed
title: Glutathione metabolism and its selective modification
source: J Biol Chem 263:17205-8
year: 1988

UniProt:P38714
type: ProteinReference
xref: UnificationXref7371
organism: BioSource1

dolichyl phosphate [ChEBI:16214]
type: SmallMoleculeReference
name: Dolichyl monophosphate
name: dolichyl phosphate
name: Dolichol phosphate
name: dolichol monophosphate
xref: UnificationXref9468

http://identifiers.org/pubmed/12034743
type: PublicationXref
id: 12034743
author: Lees-Miller, S
author: Beamish, H
author: Chen, P
author: Lavin, MF
author: Purdie, D
author: Kondo, N
author: Kaneko, H
author: Gueven, N
author: Kedar, P
author: Peng, C
author: Fukao, T
author: Beresten, S
author: Ellis, N
db: Pubmed
title: Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM.
source: J Biol Chem 277:30515-23
year: 2002

UniProt:P38702
type: ProteinReference
xref: UnificationXref5546
organism: BioSource1

UniProt:P38701
type: ProteinReference
xref: UnificationXref1725
organism: BioSource1

UniProt:P38705
type: ProteinReference
xref: UnificationXref7496
organism: BioSource1

UniProt:P38703
type: ProteinReference
xref: UnificationXref4588
organism: BioSource1

http://identifiers.org/pubmed/18195019
type: PublicationXref
id: 18195019
author: Bonacci, TM
author: Li, S
author: Kowala, M
author: Konrad, RJ
author: Moller, DE
author: Bredt, DS
author: Cao, G
author: Zhao, Y
author: Bensch, WR
author: Chen, YQ
db: Pubmed
title: Identification and characterization of a major liver lysophosphatidylcholine acyltransferase
source: J Biol Chem 283:8258-65
year: 2008

http://identifiers.org/pubmed/8969170
type: PublicationXref
id: 8969170
author: Gorski, JL
author: Xu, Y
author: Santos, MF
author: Fischer, DJ
author: Pasteris, NG
author: Tigyi, G
author: Zheng, Y
db: Pubmed
title: The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor
source: J Biol Chem 271:33169-72
year: 1996

UniProt:P16622
type: ProteinReference
xref: UnificationXref6386
organism: BioSource1

http://identifiers.org/pubmed/16906134
type: PublicationXref
id: 16906134
author: Lee, JW
author: Ackerman, SL
author: Beebe, K
author: Longo-Guess, CM
author: Davisson, MT
author: Jang, J
author: Schimmel, P
author: Cook, SA
author: Nangle, LA
author: Sundberg, JP
db: Pubmed
title: Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration
source: Nature 443:50-5
year: 2006

Conversion of palmitic acid to very long chain fatty acyl-CoAs
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction216
pathway component: BiochemicalReaction217
pathway component: BiochemicalReaction215
evidence: Evidence372
xref: RelationshipXref282
xref: UnificationXref3356
xref: UnificationXref3357
pathway order: PathwayStep369
pathway order: PathwayStep368
pathway order: PathwayStep367
display name: Synthesis of very long-chain fatty acyl-CoAs
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8603
type: UnificationXref
id: REACT_118101
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118101.7

UnificationXref8602
type: UnificationXref
id: 3673317
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673317

UnificationXref8601
type: UnificationXref
id: REACT_100030
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100030.9

UnificationXref8600
type: UnificationXref
id: 3673628
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673628

http://identifiers.org/pubmed/16906145
type: PublicationXref
id: 16906145
author: Tanaka, TU
author: Helenius, J
author: Tanaka, K
author: Hyman, AA
author: Howard, J
author: Varga, V
db: Pubmed
title: Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner
source: Nat Cell Biol 8:957-62
year: 2006

http://identifiers.org/pubmed/3053686
type: PublicationXref
id: 3053686
author: Rozen, R
author: MacKenzie, RE
author: Bell, AW
author: Hum, DW
db: Pubmed
title: Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.
source: J Biol Chem 263:15946-50
year: 1988

UnificationXref8609
type: UnificationXref
id: REACT_149938
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149938.4

UnificationXref8608
type: UnificationXref
id: 3673627
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673627

UnificationXref8607
type: UnificationXref
id: REACT_144369
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144369.5

UnificationXref8606
type: UnificationXref
id: 3673257
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673257

UnificationXref8605
type: UnificationXref
id: REACT_118528
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118528.7

UnificationXref8604
type: UnificationXref
id: 3673256
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673256

http://identifiers.org/pubmed/19336658
type: PublicationXref
id: 19336658
author: Reue, K
author: Takeuchi, K
db: Pubmed
title: Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
source: Am J Physiol Endocrinol Metab 296:E1195-209
year: 2009

http://identifiers.org/pubmed/21310273
type: PublicationXref
id: 21310273
author: Müller, JS
author: Straub, V
author: Schoser, B
author: Abicht, A
author: Hübner, A
author: Krause, S
author: Rodolico, C
author: Mallebrera, CJ
author: Strom, TM
author: Vilchez, JJ
author: Nascimento, A
author: Herrmann, R
author: Colomer, J
author: Bozorgmehr, B
author: Lochmüller, H
author: von der Hagen, M
author: Oldfors, A
author: Guergueltcheva, V
author: Urtizberea, A
author: Voit, T
author: Sieb, JP
author: Nafissi, S
author: Najmabadi, H
author: Palace, J
author: Maxwell, S
author: Diepolder, I
author: Schlotter, B
author: Muelas, N
author: Kariminejad, A
author: Dusl, M
author: Beeson, D
author: Nilipour, Y
author: Lindbergh, C
author: Steinlein, OK
author: Bushby, K
author: Senderek, J
author: Laval, SH
author: Kirschner, J
author: Cossins, J
db: Pubmed
title: Hexosamine biosynthetic pathway mutations cause neuromuscular transmission defect
source: Am J Hum Genet 88:162-72
year: 2011

http://identifiers.org/pubmed/16125054
type: PublicationXref
id: 16125054
author: Moens, U
author: Johannessen, M
author: Delghandi, MP
db: Pubmed
title: The cAMP signalling pathway activates CREB through PKA, p38 and MSK1 in NIH 3T3 cells
source: Cell Signal 17:1343-51
year: 2005

http://identifiers.org/pubmed/12890864
type: PublicationXref
id: 12890864
author: Mochizuki, Y
author: Majerus, PW
db: Pubmed
title: Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9
source: Proc Natl Acad Sci U S A 100:9768-73
year: 2003

Insulin receptor recycling
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction727
evidence: Evidence1133
xref: UnificationXref8525
xref: UnificationXref8524
pathway order: PathwayStep1139
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/7508385
type: PublicationXref
id: 7508385
author: Sjoblom, P
author: Setoguchi, Y
author: Kondo, KH
author: Eggertsen, G
author: Bjorkhem, I
author: Kai, MH
author: Okuda, K
author: Setoguchi, T
db: Pubmed
title: Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme
source: Eur J Biochem 219:357-63
year: 1994

http://identifiers.org/pubmed/19720617
type: PublicationXref
id: 19720617
author: Deponte, M
author: Hell, K
db: Pubmed
title: Disulphide bond formation in the intermembrane space of mitochondria
source: J Biochem 146:599-608
year: 2009

UnificationXref8628
type: UnificationXref
id: 3669481
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669481

UnificationXref8629
type: UnificationXref
id: 3669482
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669482

UnificationXref8626
type: UnificationXref
id: 3669479
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669479

UnificationXref8627
type: UnificationXref
id: 3669480
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669480

UnificationXref8620
type: UnificationXref
id: 3669467
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669467

UnificationXref8621
type: UnificationXref
id: 3669473
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669473

UnificationXref8624
type: UnificationXref
id: 3669476
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669476

UnificationXref8625
type: UnificationXref
id: 3669478
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669478

UnificationXref8622
type: UnificationXref
id: 3669474
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669474

UnificationXref8623
type: UnificationXref
id: 3669475
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669475

UniProt:P38989
type: ProteinReference
xref: UnificationXref129
organism: BioSource1

UnificationXref8615
type: UnificationXref
id: 3669436
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669436

UniProt:Q12102
type: ProteinReference
xref: UnificationXref933
organism: BioSource1

UnificationXref8616
type: UnificationXref
id: P39722
db: UniProt

UnificationXref8617
type: UnificationXref
id: 3669440
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669440

UnificationXref8618
type: UnificationXref
id: 3669441
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669441

UnificationXref8619
type: UnificationXref
id: 3669442
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669442

UniProt:Q12109
type: ProteinReference
xref: UnificationXref7339
organism: BioSource1

Synthesis of PIPs at the early endosome membrane
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction339
pathway component: BiochemicalReaction338
pathway component: BiochemicalReaction341
pathway component: BiochemicalReaction340
evidence: Evidence543
xref: RelationshipXref405
xref: UnificationXref4412
xref: UnificationXref4413
pathway order: PathwayStep538
pathway order: PathwayStep537
pathway order: PathwayStep540
pathway order: PathwayStep539
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8610
type: UnificationXref
id: 3673258
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673258

UnificationXref8611
type: UnificationXref
id: REACT_118333
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118333.7

UnificationXref8612
type: UnificationXref
id: 3669430
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669430

UnificationXref8613
type: UnificationXref
id: 3669431
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669431

UnificationXref8614
type: UnificationXref
id: 3669432
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669432

UniProt:P38999
type: ProteinReference
xref: UnificationXref5932
organism: BioSource1

http://identifiers.org/pubmed/218813
type: PublicationXref
id: 218813
author: Tomasselli, AG
author: Noda, LH
db: Pubmed
title: Mitochondrial GTP-AMP phosphotransferase. 2. Kinetic and equilibrium dialysis studies
source: Eur J Biochem 93:263-7
year: 1979

http://identifiers.org/pubmed/7649538
type: PublicationXref
id: 7649538
author: Sansaricq, C
author: Jakobs, C
author: Qureshi, IA
author: Snyderman, SE
author: Matsuda, I
author: Lambert, M
author: Smit, LM
author: Shapira, SK
author: Uchino, T
db: Pubmed
title: Molecular basis of phenotypic variation in patients with argininemia
source: Hum Genet 96:255-60
year: 1995

UniProt:P38992
type: ProteinReference
xref: UnificationXref3998
organism: BioSource1

http://identifiers.org/pubmed/16102047
type: PublicationXref
id: 16102047
author: Coughlin, SR
db: Pubmed
title: Protease-activated receptors in hemostasis, thrombosis and vascular biology
source: J Thromb Haemost 3:1800-14
year: 2005

UnificationXref8648
type: UnificationXref
id: 3669501
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669501

UnificationXref8649
type: UnificationXref
id: 3669502
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669502

UnificationXref8646
type: UnificationXref
id: 3669499
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669499

SequenceSite1704
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8647
type: UnificationXref
id: 3669500
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669500

SequenceSite1705
type: SequenceSite
position status: EQUAL
sequence position: 299

UnificationXref8644
type: UnificationXref
id: 3669497
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669497

SequenceSite1706
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8645
type: UnificationXref
id: 3669498
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669498

SequenceSite1707
type: SequenceSite
position status: EQUAL
sequence position: 326

UnificationXref8642
type: UnificationXref
id: 3669495
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669495

SequenceSite1700
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8643
type: UnificationXref
id: 3669496
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669496

SequenceSite1701
type: SequenceSite
position status: EQUAL
sequence position: 373

UnificationXref8640
type: UnificationXref
id: 3669493
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669493

SequenceSite1702
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8641
type: UnificationXref
id: 3669494
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669494

SequenceSite1703
type: SequenceSite
position status: EQUAL
sequence position: 341

UnificationXref8650
type: UnificationXref
id: 3669504
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669504

SequenceSite1709
type: SequenceSite
position status: EQUAL
sequence position: 323

UniProt:P38968
type: ProteinReference
xref: UnificationXref1810
organism: BioSource1

SequenceSite1708
type: SequenceSite
position status: EQUAL
sequence position: 1

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
type: Pathway
data source: Provenance1
pathway component: REACT 107815.9
pathway component: REACT 157927.3
evidence: Evidence897
xref: UnificationXref7120
xref: UnificationXref7121
pathway order: PathwayStep893
pathway order: PathwayStep908
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite1710
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8637
type: UnificationXref
id: 3669490
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669490

UnificationXref8638
type: UnificationXref
id: 3669491
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669491

UnificationXref8639
type: UnificationXref
id: 3669492
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669492

UnificationXref8633
type: UnificationXref
id: 3669486
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669486

SequenceSite1717
type: SequenceSite
position status: EQUAL
sequence position: 1074

UnificationXref8634
type: UnificationXref
id: 3669487
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669487

SequenceSite1718
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q12123
type: ProteinReference
xref: UnificationXref7550
organism: BioSource1

UnificationXref8635
type: UnificationXref
id: 3669488
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669488

SequenceSite1715
type: SequenceSite
position status: EQUAL
sequence position: 272

UnificationXref8636
type: UnificationXref
id: 3669489
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669489

SequenceSite1716
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1713
type: SequenceSite
position status: EQUAL
sequence position: 690

UnificationXref8630
type: UnificationXref
id: 3669483
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669483

SequenceSite1714
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8631
type: UnificationXref
id: 3669484
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669484

SequenceSite1711
type: SequenceSite
position status: EQUAL
sequence position: 620

UnificationXref8632
type: UnificationXref
id: 3669485
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669485

SequenceSite1712
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1719
type: SequenceSite
position status: EQUAL
sequence position: 933

http://identifiers.org/pubmed/16102042
type: PublicationXref
id: 16102042
author: Pearce, AC
author: Auger, JM
author: McCarty, OJ
author: Watson, SP
db: Pubmed
title: GPVI and integrin alphaIIb beta3 signaling in platelets
source: J Thromb Haemost 3:1752-62
year: 2005

http://identifiers.org/pubmed/15033637
type: PublicationXref
id: 15033637
author: Yao, S
author: Manolescu, A
author: Chen, XZ
author: Young, JD
author: Li, Q
author: Cheeseman, CI
author: Slugoski, M
author: Ritzel, M
db: Pubmed
title: Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine
source: Am J Physiol Gastrointest Liver Physiol 287:G236-42
year: 2004

UniProt:P38972
type: ProteinReference
xref: UnificationXref5046
organism: BioSource1

http://identifiers.org/pubmed/11252894
type: PublicationXref
id: 11252894
author: Kirchhausen, T
db: Pubmed
title: Three ways to make a vesicle
source: Nat Rev Mol Cell Biol 1:187-98
year: 2000

UnificationXref1758
type: UnificationXref
id: 3667125
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667125

UnificationXref1757
type: UnificationXref
id: 3667124
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667124

UnificationXref1756
type: UnificationXref
id: P07260
db: UniProt

UnificationXref1755
type: UnificationXref
id: 3667120
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667120

UnificationXref1754
type: UnificationXref
id: 3667118
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667118

UnificationXref1753
type: UnificationXref
id: 3667119
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667119

UnificationXref1752
type: UnificationXref
id: P10081
db: UniProt

UnificationXref1751
type: UnificationXref
id: 3667127
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667127

UnificationXref1750
type: UnificationXref
id: 3667111
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667111

UnificationXref8670
type: UnificationXref
id: 3669531
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669531

UnificationXref8671
type: UnificationXref
id: 3669533
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669533

UnificationXref8672
type: UnificationXref
id: REACT_79350
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79350.9

UnificationXref8663
type: UnificationXref
id: 3669524
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669524

SequenceSite1725
type: SequenceSite
position status: EQUAL
sequence position: 851

UnificationXref8662
type: UnificationXref
id: 3669523
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669523

SequenceSite1724
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8665
type: UnificationXref
id: 3669526
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669526

SequenceSite1723
type: SequenceSite
position status: EQUAL
sequence position: 389

UnificationXref8664
type: UnificationXref
id: 3669525
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669525

SequenceSite1722
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8667
type: UnificationXref
id: 3669528
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669528

SequenceSite1729
type: SequenceSite
position status: EQUAL
sequence position: 409

UnificationXref8666
type: UnificationXref
id: 3669527
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669527

SequenceSite1728
type: SequenceSite
position status: EQUAL
sequence position: 378

UnificationXref8669
type: UnificationXref
id: 3669530
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669530

SequenceSite1727
type: SequenceSite
position status: EQUAL
sequence position: 377

UnificationXref8668
type: UnificationXref
id: 3669529
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669529

SequenceSite1726
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1721
type: SequenceSite
position status: EQUAL
sequence position: 303

SequenceSite1720
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1759
type: UnificationXref
id: 3667126
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667126

http://identifiers.org/pubmed/16243729
type: PublicationXref
id: 16243729
author: Chen, C
author: Yu, L
author: Ye, GM
author: Guo, JH
author: Huang, S
author: Wan, B
author: Han, DD
db: Pubmed
title: Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7
source: DNA Seq 16:386-90
year: 2005

UnificationXref1745
type: UnificationXref
id: 3667044
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667044

UnificationXref1744
type: UnificationXref
id: P0CX40
db: UniProt

UnificationXref1747
type: UnificationXref
id: 3667046
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667046

UnificationXref1746
type: UnificationXref
id: P0CX39
db: UniProt

http://identifiers.org/pubmed/12676795
type: PublicationXref
id: 12676795
author: Reichardt, LF
author: Huang, EJ
db: Pubmed
title: Trk receptors: roles in neuronal signal transduction
source: Annu Rev Biochem 72:609-42
year: 2003

UnificationXref1741
type: UnificationXref
id: P35997
db: UniProt

UnificationXref1740
type: UnificationXref
id: 3666961
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666961

UnificationXref1743
type: UnificationXref
id: 3666966
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666966

http://identifiers.org/pubmed/12676794
type: PublicationXref
id: 12676794
author: Shilatifard, A
author: Conaway, JW
author: Conaway, RC
db: Pubmed
title: The RNA polymerase II elongation complex.
source: Annu Rev Biochem 72:693-715
year: 2003

UnificationXref1742
type: UnificationXref
id: 3666965
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666965

UnificationXref8660
type: UnificationXref
id: 3669521
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669521

UnificationXref8661
type: UnificationXref
id: 3669522
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669522

UnificationXref8654
type: UnificationXref
id: P38822
db: UniProt

SequenceSite1734
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8653
type: UnificationXref
id: 3669508
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669508

SequenceSite1733
type: SequenceSite
position status: EQUAL
sequence position: 520

UnificationXref8652
type: UnificationXref
id: P32873
db: UniProt

SequenceSite1736
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8651
type: UnificationXref
id: REACT_30773
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30773.10

SequenceSite1735
type: SequenceSite
position status: EQUAL
sequence position: 487

UnificationXref8658
type: UnificationXref
id: P38339
db: UniProt

SequenceSite1738
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref8657
type: UnificationXref
id: 3669516
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669516

SequenceSite1737
type: SequenceSite
position status: EQUAL
sequence position: 672

UnificationXref8656
type: UnificationXref
id: P35688
db: UniProt

UnificationXref8655
type: UnificationXref
id: 3669512
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669512

SequenceSite1739
type: SequenceSite
position status: EQUAL
sequence position: 199

UnificationXref8659
type: UnificationXref
id: 3669520
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669520

UnificationXref1748
type: UnificationXref
id: 3667047
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667047

SequenceSite1730
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1749
type: UnificationXref
id: 3667067
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667067

SequenceSite1732
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1731
type: SequenceSite
position status: EQUAL
sequence position: 495

UnificationXref1776
type: UnificationXref
id: 3669919
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669919

UnificationXref1775
type: UnificationXref
id: 3669918
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669918

UnificationXref1774
type: UnificationXref
id: 3669917
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669917

UnificationXref1773
type: UnificationXref
id: 3669916
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669916

UnificationXref1779
type: UnificationXref
id: 3669921
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669921

UnificationXref1778
type: UnificationXref
id: 3669920
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669920

UnificationXref1777
type: UnificationXref
id: P38810
db: UniProt

UnificationXref8691
type: UnificationXref
id: 3673406
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673406

UnificationXref8692
type: UnificationXref
id: REACT_85042
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85042.9

UnificationXref8693
type: UnificationXref
id: 3670667
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670667

UnificationXref8694
type: UnificationXref
id: REACT_130639
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130639.5

UnificationXref1772
type: UnificationXref
id: 3669915
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669915

UnificationXref1771
type: UnificationXref
id: P40482
db: UniProt

UnificationXref1770
type: UnificationXref
id: 3669914
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669914

UnificationXref8690
type: UnificationXref
id: REACT_88823
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88823.9

UnificationXref8689
type: UnificationXref
id: 3673405
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673405

UnificationXref8688
type: UnificationXref
id: REACT_29798
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29798.10

SequenceSite1749
type: SequenceSite
position status: EQUAL
sequence position: 556

SequenceSite1748
type: SequenceSite
position status: EQUAL
sequence position: 29

UnificationXref8685
type: UnificationXref
id: 3669466
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669466

SequenceSite1747
type: SequenceSite
position status: EQUAL
sequence position: 472

UnificationXref8684
type: UnificationXref
id: 3669465
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669465

SequenceSite1746
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8687
type: UnificationXref
id: 3669534
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669534

SequenceSite1745
type: SequenceSite
position status: EQUAL
sequence position: 213

UnificationXref8686
type: UnificationXref
id: REACT_28721
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28721.10

SequenceSite1744
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1743
type: SequenceSite
position status: EQUAL
sequence position: 369

SequenceSite1742
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1741
type: SequenceSite
position status: EQUAL
sequence position: 367

SequenceSite1740
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/6788766
type: PublicationXref
id: 6788766
author: Sagawa, N
author: Johnston, JM
author: Okazaki, T
author: Bleasdale, JE
author: MacDonald, PC
author: Okita, JR
db: Pubmed
title: Diacylglycerol metabolism and arachidonic acid release in human fetal membranes and decidua vera
source: J Biol Chem 256:7316-21
year: 1981

http://identifiers.org/pubmed/7118399
type: PublicationXref
id: 7118399
author: Lee, HH
author: Lo, KY
author: Pai, SH
author: Pan, F
db: Pubmed
title: Purification and subunit structure studies of human placental threonyl-tRNA synthetase
source: Int J Pept Protein Res 19:300-9
year: 1982

UnificationXref1763
type: UnificationXref
id: 3668680
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668680

UnificationXref1762
type: UnificationXref
id: 3668679
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668679

Choline phosphate [ChEBI:3667]
type: SmallMoleculeReference
name: Choline phosphate
name: O-Phosphocholine
name: Phosphorylcholine
name: Phosphocholine
xref: UnificationXref4650

UnificationXref1765
type: UnificationXref
id: 3673341
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673341

UnificationXref1764
type: UnificationXref
id: REACT_159970
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159970.3

UnificationXref1767
type: UnificationXref
id: 3673342
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673342

UnificationXref1766
type: UnificationXref
id: REACT_79537
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79537.9

UnificationXref1769
type: UnificationXref
id: P53953
db: UniProt

UnificationXref1768
type: UnificationXref
id: REACT_45663
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_45663.10

UnificationXref8682
type: UnificationXref
id: 3669463
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669463

UnificationXref8683
type: UnificationXref
id: 3669464
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669464

http://identifiers.org/pubmed/16747180
type: PublicationXref
id: 16747180
author: Eggleston, LV
author: Krebs, HA
db: Pubmed
title: The oxidation of pyruvate in pigeon breast muscle
source: Biochem J 34:442-459
year: 1940

UnificationXref8680
type: UnificationXref
id: 3669454
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669454

UnificationXref8681
type: UnificationXref
id: 3669455
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669455

http://identifiers.org/pubmed/15021249
type: PublicationXref
id: 15021249
author: de Koning, TJ
author: Klomp, LW
db: Pubmed
title: Serine-deficiency syndromes
source: Curr Opin Neurol 17:197-204
year: 2004

UnificationXref1761
type: UnificationXref
id: 3668678
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668678

UnificationXref1760
type: UnificationXref
id: 3668677
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668677

UnificationXref8679
type: UnificationXref
id: 3669453
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669453

SequenceSite1759
type: SequenceSite
position status: EQUAL
sequence position: 587

UnificationXref8678
type: UnificationXref
id: 3669452
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669452

UnificationXref8677
type: UnificationXref
id: 3669451
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669451

UnificationXref8676
type: UnificationXref
id: Q12434
db: UniProt

SequenceSite1756
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8675
type: UnificationXref
id: 3669447
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669447

SequenceSite1755
type: SequenceSite
position status: EQUAL
sequence position: 2044

UnificationXref8674
type: UnificationXref
id: 3669446
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669446

SequenceSite1758
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8673
type: UnificationXref
id: P39958
db: UniProt

SequenceSite1757
type: SequenceSite
position status: EQUAL
sequence position: 481

SequenceSite1752
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1751
type: SequenceSite
position status: EQUAL
sequence position: 301

SequenceSite1754
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1753
type: SequenceSite
position status: EQUAL
sequence position: 292

SequenceSite1750
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:P16661
type: ProteinReference
xref: UnificationXref9599
organism: BioSource1

UnificationXref3218
type: UnificationXref
id: 3672604
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672604

UnificationXref1793
type: UnificationXref
id: 3669899
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669899

UnificationXref3219
type: UnificationXref
id: 3672605
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672605

UnificationXref1794
type: UnificationXref
id: 3669903
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669903

UnificationXref1791
type: UnificationXref
id: 3669897
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669897

http://identifiers.org/pubmed/16141327
type: PublicationXref
id: 16141327
author: Centeno, F
author: Mora, A
author: Christianson, DW
author: Ochoa, AC
author: Rodriguez, PC
author: Sabio, G
author: Di Costanzo, L
db: Pubmed
title: Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response
source: Proc Natl Acad Sci U S A 102:13058-63
year: 2005

UnificationXref1792
type: UnificationXref
id: 3669898
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669898

UnificationXref3214
type: UnificationXref
id: 3672598
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672598

UnificationXref3215
type: UnificationXref
id: P38710
db: UniProt

UnificationXref1790
type: UnificationXref
id: 3669896
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669896

UnificationXref3216
type: UnificationXref
id: 3672602
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672602

UnificationXref3217
type: UnificationXref
id: 3672603
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672603

UnificationXref3210
type: UnificationXref
id: CHEBI:17268
db: ChEBI

UnificationXref3211
type: UnificationXref
id: 426910
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426910

UnificationXref3212
type: UnificationXref
id: REACT_20018
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20018.2

UnificationXref1799
type: UnificationXref
id: 3669954
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669954

UnificationXref3213
type: UnificationXref
id: Q05533
db: UniProt

UnificationXref1797
type: UnificationXref
id: 3669910
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669910

UnificationXref1798
type: UnificationXref
id: 3669911
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669911

UnificationXref1795
type: UnificationXref
id: 3669904
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669904

UnificationXref1796
type: UnificationXref
id: 3669905
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669905

SequenceSite1760
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1761
type: SequenceSite
position status: EQUAL
sequence position: 479

SequenceSite1764
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1765
type: SequenceSite
position status: EQUAL
sequence position: 816

SequenceSite1762
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1763
type: SequenceSite
position status: EQUAL
sequence position: 816

SequenceSite1768
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/10024882
type: PublicationXref
id: 10024882
author: Tirode, F
author: Coin, F
author: Egly, JM
author: Busso, D
db: Pubmed
title: Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7
source: Mol Cell 3:87-95
year: 1999

SequenceSite1769
type: SequenceSite
position status: EQUAL
sequence position: 1358

SequenceSite1766
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1767
type: SequenceSite
position status: EQUAL
sequence position: 587

UniProt:Q05788
type: ProteinReference
xref: UnificationXref5176
organism: BioSource1

Signaling by Wnt
type: Pathway
data source: Provenance1
pathway component: REACT 165989.1
evidence: Evidence1192
xref: UnificationXref8750
xref: UnificationXref8749
pathway order: PathwayStep1198
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3209
type: UnificationXref
id: REACT_152225
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152225.1

UnificationXref1780
type: UnificationXref
id: 3669922
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669922

UnificationXref1781
type: UnificationXref
id: P15303
db: UniProt

UnificationXref3207
type: UnificationXref
id: CHEBI:18384
db: ChEBI

UnificationXref1782
type: UnificationXref
id: 3669923
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669923

UnificationXref3208
type: UnificationXref
id: 1629753
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629753

UnificationXref1783
type: UnificationXref
id: 3669924
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669924

UnificationXref3205
type: UnificationXref
id: 3672642
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672642

TAH18
type: ProteinReference
name: UniProt:Q12181 TAH18
name: YP9499.06
name: YPR048W
xref: UnificationXref6606
comment: FUNCTION Probable oxidoreductase which may be involved in DNA replication.SIMILARITY In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.SIMILARITY Contains 1 FAD-binding FR-type domain.SIMILARITY Contains 1 flavodoxin-like domain.
organism: BioSource1

UnificationXref3206
type: UnificationXref
id: REACT_152558
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152558.3

UnificationXref3203
type: UnificationXref
id: 1629739
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629739

UnificationXref3204
type: UnificationXref
id: REACT_150507
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150507.1

UnificationXref3201
type: UnificationXref
id: REACT_2897
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2897.4

UnificationXref1788
type: UnificationXref
id: 3669891
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669891

UnificationXref3202
type: UnificationXref
id: CHEBI:17816
db: ChEBI

UnificationXref1789
type: UnificationXref
id: 3669895
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669895

http://identifiers.org/pubmed/15971998
type: PublicationXref
id: 15971998
author: Sano, H
author: Sano, E
author: Lane, WS
author: Mîinea, CP
author: Lienhard, GE
author: Fukuda, M
author: Kane, S
author: Peränen, J
db: Pubmed
title: AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain
source: Biochem J 391:87-93
year: 2005

UnificationXref3200
type: UnificationXref
id: 114520
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114520

UnificationXref1784
type: UnificationXref
id: P20606
db: UniProt

UnificationXref1785
type: UnificationXref
id: 3669886
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669886

UnificationXref1786
type: UnificationXref
id: 3669887
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669887

UnificationXref1787
type: UnificationXref
id: 3669909
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669909

SequenceSite1770
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1771
type: SequenceSite
position status: EQUAL
sequence position: 887

SequenceSite1772
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1773
type: SequenceSite
position status: EQUAL
sequence position: 2098

SequenceSite1774
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1775
type: SequenceSite
position status: EQUAL
sequence position: 907

SequenceSite1776
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8697
type: UnificationXref
id: 3673496
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673496

SequenceSite1777
type: SequenceSite
position status: EQUAL
sequence position: 782

UniProt:Q12184
type: ProteinReference
xref: UnificationXref6561
organism: BioSource1

UnificationXref8698
type: UnificationXref
id: REACT_99474
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99474.9

SequenceSite1778
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8695
type: UnificationXref
id: 3673493
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673493

SequenceSite1779
type: SequenceSite
position status: EQUAL
sequence position: 644

UnificationXref8696
type: UnificationXref
id: REACT_114304
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114304.8

UniProt:Q12189
type: ProteinReference
xref: UnificationXref3038
organism: BioSource1

UnificationXref8699
type: UnificationXref
id: 3670659
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670659

UnificationXref3236
type: UnificationXref
id: CHEBI:18169
db: ChEBI

UnificationXref3237
type: UnificationXref
id: 1629731
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629731

UnificationXref3238
type: UnificationXref
id: REACT_150575
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150575.1

UnificationXref3239
type: UnificationXref
id: P11986
db: UniProt

http://identifiers.org/pubmed/18678864
type: PublicationXref
id: 18678864
author: Esaki, M
author: Kuroyanagi-Hasegawa, M
author: Yokota, M
author: Endo, T
author: Yamano, K
db: Pubmed
title: Step-size analyses of the mitochondrial Hsp70 import motor reveal the Brownian ratchet in operation
source: J Biol Chem 283:27325-32
year: 2008

SequenceSite1790
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref3230
type: UnificationXref
id: REACT_27390
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27390.2

UnificationXref3231
type: UnificationXref
id: 3672613
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672613

UnificationXref3232
type: UnificationXref
id: REACT_152700
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152700.3

UnificationXref3233
type: UnificationXref
id: CHEBI:4170
db: ChEBI

UnificationXref3234
type: UnificationXref
id: 1629756
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629756

UnificationXref3235
type: UnificationXref
id: REACT_152414
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152414.1

SequenceSite1786
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1787
type: SequenceSite
position status: EQUAL
sequence position: 621

SequenceSite1784
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1785
type: SequenceSite
position status: EQUAL
sequence position: 1496

SequenceSite1782
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1783
type: SequenceSite
position status: EQUAL
sequence position: 1496

SequenceSite1780
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1781
type: SequenceSite
position status: EQUAL
sequence position: 1496

http://identifiers.org/pubmed/15075209
type: PublicationXref
id: 15075209
author: Kahlenberg, JM
author: Dubyak, GR
db: Pubmed
title: Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release
source: Am J Physiol Cell Physiol 286:C1100-8
year: 2004

SequenceSite1788
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1789
type: SequenceSite
position status: EQUAL
sequence position: 907

UnificationXref3227
type: UnificationXref
id: REACT_159005
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159005.3

UnificationXref3228
type: UnificationXref
id: CHEBI:18297
db: ChEBI

UnificationXref3225
type: UnificationXref
id: 3672611
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672611

UnificationXref3226
type: UnificationXref
id: 3672663
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672663

UnificationXref3229
type: UnificationXref
id: 870330
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=870330

UnificationXref3220
type: UnificationXref
id: 3672606
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672606

UnificationXref3223
type: UnificationXref
id: 3672609
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672609

UnificationXref3224
type: UnificationXref
id: 3672610
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672610

UnificationXref3221
type: UnificationXref
id: 3672607
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672607

UnificationXref3222
type: UnificationXref
id: 3672608
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672608

SequenceSite1795
type: SequenceSite
position status: EQUAL
sequence position: 782

SequenceSite1796
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1797
type: SequenceSite
position status: EQUAL
sequence position: 2098

SequenceSite1798
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q05775
type: ProteinReference
xref: UnificationXref1606
organism: BioSource1

SequenceSite1791
type: SequenceSite
position status: EQUAL
sequence position: 782

SequenceSite1792
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1793
type: SequenceSite
position status: EQUAL
sequence position: 2098

SequenceSite1794
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1799
type: SequenceSite
position status: EQUAL
sequence position: 907

UniProt:Q07938
type: ProteinReference
xref: UnificationXref6141
organism: BioSource1

SequenceSite1699
type: SequenceSite
position status: EQUAL
sequence position: 293

SequenceSite1698
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/16624818
type: PublicationXref
id: 16624818
author: Gulmezian, M
author: Marbois, B
author: Gin, P
author: Clarke, CF
author: Jonassen, T
author: Tran, UC
db: Pubmed
title: Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis
source: J Biol Chem 281:16401-9
year: 2006

SequenceSite1697
type: SequenceSite
position status: EQUAL
sequence position: 418

SequenceSite1696
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1695
type: SequenceSite
position status: EQUAL
sequence position: 615

SequenceSite1694
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1693
type: SequenceSite
position status: EQUAL
sequence position: 503

SequenceSite1692
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/16777603
type: PublicationXref
id: 16777603
author: Cole, PA
author: Shen, K
author: Zhang, X
author: Gureasko, J
author: Kuriyan, J
db: Pubmed
title: An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
source: Cell 125:1137-49
year: 2006

UnificationXref3121
type: UnificationXref
id: 2023932
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023932

UnificationXref3120
type: UnificationXref
id: CHEBI:62919
db: ChEBI

UnificationXref3123
type: UnificationXref
id: CHEBI:62923
db: ChEBI

UnificationXref3122
type: UnificationXref
id: REACT_151781
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151781.1

UnificationXref3125
type: UnificationXref
id: REACT_151603
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151603.1

UnificationXref3124
type: UnificationXref
id: 2023931
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023931

UnificationXref3127
type: UnificationXref
id: REACT_156766
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156766.3

UnificationXref3126
type: UnificationXref
id: 3672621
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672621

UnificationXref3129
type: UnificationXref
id: REACT_155187
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155187.3

UnificationXref3128
type: UnificationXref
id: 3673615
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673615

PublicationXref1835
type: PublicationXref
author: Page, C
author: Vermylen, J
author: Fuster, V
author: Gresele, P
title: Platelets in thrombotic and non-thrombotic disorders.
source: 435-437
year: 2002

http://identifiers.org/pubmed/8035818
type: PublicationXref
id: 8035818
author: Yoo, CJ
author: Wolin, SL
db: Pubmed
title: La proteins from Drosophila melanogaster and Saccharomyces cerevisiae: a yeast homolog of the La autoantigen is dispensable for growth.
source: Mol Cell Biol 14:5412-24
year: 1994

SequenceSite1689
type: SequenceSite
position status: EQUAL
sequence position: 574

SequenceSite1686
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1685
type: SequenceSite
position status: EQUAL
sequence position: 300

SequenceSite1688
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1687
type: SequenceSite
position status: EQUAL
sequence position: 417

http://identifiers.org/pubmed/11772397
type: PublicationXref
id: 11772397
author: Shaw, Stephen
author: Graham, Caroline
author: Fisher, Robert J
author: Liu, Yin
author: Li, Aiqun
db: Pubmed
title: Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction
source: Biochem. J. 361:255-65
year: 2002

SequenceSite1682
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1681
type: SequenceSite
position status: EQUAL
sequence position: 227

SequenceSite1684
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1683
type: SequenceSite
position status: EQUAL
sequence position: 419

UnificationXref3132
type: UnificationXref
id: 1629755
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629755

UnificationXref3131
type: UnificationXref
id: REACT_25926
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25926.2

UnificationXref3130
type: UnificationXref
id: 994141
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=994141

SequenceSite1690
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1691
type: SequenceSite
position status: EQUAL
sequence position: 732

UnificationXref3136
type: UnificationXref
id: 3672624
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672624

UnificationXref3135
type: UnificationXref
id: 3672623
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672623

UnificationXref3134
type: UnificationXref
id: 3672622
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672622

UnificationXref3133
type: UnificationXref
id: REACT_152024
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152024.1

UnificationXref3139
type: UnificationXref
id: CHEBI:62926
db: ChEBI

UnificationXref3138
type: UnificationXref
id: REACT_128457
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128457.5

PublicationXref1821
type: PublicationXref
author: Marks, F
author: Raab, I
title: The second messenger system of mouse epidermis. IV. Cyclic AMP and cyclic GMP phosphodiesterase.
source: Biochim. Biophys. Acta 334:368-377
year: 1974

UnificationXref3137
type: UnificationXref
id: 3672667
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672667

YLR008C
type: ProteinReference
name: UniProt:Q07914 PAM18
name: PAM18
name: TIM14
xref: UnificationXref799
comment: FUNCTION Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1).SUBUNIT Homodimer and heterodimer with PAM16/TIM16. Homodimerization may not be relevant in vivo, while heterodimerization is essential for activity regulation of mtHSP70. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18/TIM14. Interacts directly with mtHsp70. Interacts directly with TIM17 subunit of the TIM23 complex.DOMAIN The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16.SIMILARITY Belongs to the TIM14 family.SIMILARITY Contains 1 J domain.
organism: BioSource1

UnificationXref3150
type: UnificationXref
id: 3672632
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672632

UnificationXref3145
type: UnificationXref
id: 2023943
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023943

UnificationXref3144
type: UnificationXref
id: REACT_152125
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152125.1

UnificationXref3147
type: UnificationXref
id: 1500648
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500648

UnificationXref3146
type: UnificationXref
id: REACT_150700
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150700.1

UnificationXref3141
type: UnificationXref
id: REACT_151437
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151437.1

UnificationXref3140
type: UnificationXref
id: 1629736
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629736

PublicationXref1815
type: PublicationXref
author: Nyborg, J
author: Merrick, WC
title: The Protein Biosynthesis Elongation Cycle
source: Translational Control of Gene Expression89-127
year: 2000

UnificationXref3143
type: UnificationXref
id: 1629747
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629747

UnificationXref3142
type: UnificationXref
id: CHEBI:62927
db: ChEBI

UnificationXref3149
type: UnificationXref
id: Q99321
db: UniProt

UnificationXref3148
type: UnificationXref
id: REACT_151505
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151505.1

UnificationXref3160
type: UnificationXref
id: 1629765
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629765

UnificationXref3161
type: UnificationXref
id: REACT_150662
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150662.1

UnificationXref3158
type: UnificationXref
id: 1629770
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629770

UnificationXref3157
type: UnificationXref
id: REACT_155930
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155930.3

UnificationXref3156
type: UnificationXref
id: 3672653
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672653

UnificationXref3155
type: UnificationXref
id: REACT_150686
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150686.1

UnificationXref3154
type: UnificationXref
id: 1629738
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629738

UnificationXref3153
type: UnificationXref
id: REACT_156945
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156945.3

UnificationXref3152
type: UnificationXref
id: 3672640
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672640

UnificationXref3151
type: UnificationXref
id: 3672633
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672633

PublicationXref1801
type: PublicationXref
author: Donahue, TF
title: Genetic approaches to translation initiation in Saccharomyces cerevisiae.
source: Translational Control of Gene Expression. N. Sonenberg, J.W. Hershey and M.B. Mathews (eds.)487-502
year: 2000

UnificationXref3159
type: UnificationXref
id: REACT_151222
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151222.1

UnificationXref1707
type: UnificationXref
id: P0CX51
db: UniProt

UnificationXref1706
type: UnificationXref
id: 3666873
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666873

UnificationXref1705
type: UnificationXref
id: P0CX52
db: UniProt

UnificationXref1704
type: UnificationXref
id: 3666858
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666858

UnificationXref3170
type: UnificationXref
id: REACT_157150
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157150.3

UnificationXref3172
type: UnificationXref
id: REACT_151822
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151822.1

UnificationXref1709
type: UnificationXref
id: 3666876
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666876

UnificationXref3171
type: UnificationXref
id: 1629740
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629740

UnificationXref1708
type: UnificationXref
id: 3666875
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666875

http://identifiers.org/pubmed/3061785
type: PublicationXref
id: 3061785
author: Duckworth, WC
db: Pubmed
title: Insulin degradation: mechanisms, products, and significance.
source: Endocr Rev 9:319-45
year: 1989

UnificationXref3162
type: UnificationXref
id: 3672671
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672671

UnificationXref3163
type: UnificationXref
id: REACT_159392
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159392.3

UnificationXref3164
type: UnificationXref
id: 3672630
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672630

http://identifiers.org/pubmed/11564948
type: PublicationXref
id: 11564948
author: Sánchez-Jiménez, F
author: Urdiales, JL
author: Medina, MA
db: Pubmed
title: Polyamine metabolism revisited
source: Eur J Gastroenterol Hepatol 13:1015-9
year: 2001

UniProt:P32377
type: ProteinReference
xref: UnificationXref3664
organism: BioSource1

UnificationXref3165
type: UnificationXref
id: 3672631
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672631

N3419
type: ProteinReference
name: COQ2
name: YNR041C
name: UniProt:P32378 COQ2
xref: UnificationXref814
comment: CATALYTIC ACTIVITY A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.PATHWAY Cofactor biosynthesis; ubiquinone biosynthesis.SIMILARITY Belongs to the UbiA prenyltransferase family.
organism: BioSource1

UnificationXref3166
type: UnificationXref
id: 3672634
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672634

UnificationXref1702
type: UnificationXref
id: 3667066
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667066

UniProt:P32379
type: ProteinReference
xref: UnificationXref1081
organism: BioSource1

UnificationXref3167
type: UnificationXref
id: 3672635
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672635

UnificationXref1703
type: UnificationXref
id: P48589
db: UniProt

UnificationXref3168
type: UnificationXref
id: 3672636
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672636

UnificationXref1700
type: UnificationXref
id: 3666844
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666844

UnificationXref3169
type: UnificationXref
id: 3672657
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672657

UnificationXref1701
type: UnificationXref
id: 3666845
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666845

UnificationXref1716
type: UnificationXref
id: 3666916
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666916

UnificationXref1715
type: UnificationXref
id: Q3E754
db: UniProt

UnificationXref1718
type: UnificationXref
id: 3666920
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666920

UnificationXref1717
type: UnificationXref
id: P0C0V8
db: UniProt

UnificationXref3183
type: UnificationXref
id: REACT_154155
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154155.3

UnificationXref3182
type: UnificationXref
id: 3672626
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672626

UnificationXref1719
type: UnificationXref
id: 3666921
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666921

UnificationXref3181
type: UnificationXref
id: REACT_152078
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152078.1

UnificationXref3180
type: UnificationXref
id: 1629759
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629759

http://identifiers.org/pubmed/16872679
type: PublicationXref
id: 16872679
author: Pikuleva, IA
db: Pubmed
title: Cytochrome P450s and cholesterol homeostasis
source: Pharmacol Ther 112:761-73
year: 2006

UniProt:Q02724
type: ProteinReference
xref: UnificationXref6
organism: BioSource1

YHR079C
type: ProteinReference
name: IRE1
name: UniProt:P32361 IRE1
name: ERN1
xref: UnificationXref9810
comment: FUNCTION Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices HAC1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes.CATALYTIC ACTIVITY ATP + a protein = ADP + a phosphoprotein.COFACTOR Magnesium.ENZYME REGULATION The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.SUBUNIT Homodimer; in response to the accumulation of unfolded proteins.PTM Autophosphorylated mainly on serine residues.MISCELLANEOUS Present with 259 molecules/cell in log phase SD medium.SIMILARITY Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.SIMILARITY Contains 1 KEN domain.SIMILARITY Contains 1 protein kinase domain.
organism: BioSource1

http://identifiers.org/pubmed/2981478
type: PublicationXref
id: 2981478
author: Neely, JR
author: Robishaw, JD
db: Pubmed
title: Coenzyme A metabolism
source: Am J Physiol 248:E1-9
year: 1985

UnificationXref3175
type: UnificationXref
id: REACT_151197
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151197.1

UniProt:P32366
type: ProteinReference
xref: UnificationXref1927
organism: BioSource1

UnificationXref3176
type: UnificationXref
id: 2023974
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023974

UnificationXref3173
type: UnificationXref
id: CHEBI:62922
db: ChEBI

UniProt:P32364
type: ProteinReference
xref: UnificationXref7989
organism: BioSource1

UnificationXref3174
type: UnificationXref
id: 1629761
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629761

UnificationXref1710
type: UnificationXref
id: Q3E792
db: UniProt

UnificationXref3179
type: UnificationXref
id: REACT_159616
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159616.3

UnificationXref1711
type: UnificationXref
id: 3666943
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666943

UnificationXref1712
type: UnificationXref
id: P0C0T4
db: UniProt

YBR123C
type: ProteinReference
name: YBR0919
name: TFC1
name: UniProt:P32367 TFC1
xref: UnificationXref7001
comment: FUNCTION TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Participates in the interconnection of tauA with tauB via its contacts with TFC3 and TFC6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability.SUBUNIT Component of the TFIIIC complex composed of TFC1, TFC3, TFC4, TFC6, TFC7 and TFC8. The subunits are organized in two globular domains, tauA and tauB, connected by a proteolysis-sensitive and flexible linker. Interacts with TFC3, TFC4 and TFC6.MISCELLANEOUS Present with 15800 molecules/cell in log phase SD medium.SIMILARITY Belongs to the TFIIIC subunit 5 family.
organism: BioSource1

UnificationXref3177
type: UnificationXref
id: REACT_152042
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152042.1

UnificationXref1713
type: UnificationXref
id: 3666947
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666947

UniProt:P32368
type: ProteinReference
xref: UnificationXref4293
organism: BioSource1

UnificationXref3178
type: UnificationXref
id: 3672691
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672691

UnificationXref1714
type: UnificationXref
id: 3666948
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666948

UnificationXref3192
type: UnificationXref
id: REACT_159044
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159044.3

UnificationXref3191
type: UnificationXref
id: 3672638
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672638

UnificationXref3194
type: UnificationXref
id: REACT_146247
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146247.5

UnificationXref3193
type: UnificationXref
id: 3672655
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672655

UnificationXref1729
type: UnificationXref
id: P0CX55
db: UniProt

P9677.11
type: ProteinReference
name: RPC82
name: YPR190C
name: RPC3
name: UniProt:P32349 RPC82
xref: UnificationXref7027
comment: FUNCTION DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.SUBUNIT Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.MISCELLANEOUS Present with 2520 molecules/cell in log phase SD medium.SIMILARITY Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
organism: BioSource1

UnificationXref1728
type: UnificationXref
id: 3666867
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666867

UnificationXref3190
type: UnificationXref
id: REACT_151108
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151108.1

UnificationXref1727
type: UnificationXref
id: Q01855
db: UniProt

UnificationXref1726
type: UnificationXref
id: 3666912
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666912

UnificationXref3188
type: UnificationXref
id: REACT_151204
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151204.1

UnificationXref1724
type: UnificationXref
id: 3666998
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666998

UnificationXref3189
type: UnificationXref
id: 2023968
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023968

UnificationXref1725
type: UnificationXref
id: P38701
db: UniProt

UnificationXref1722
type: UnificationXref
id: P0CX34
db: UniProt

UnificationXref1723
type: UnificationXref
id: 3666997
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666997

UnificationXref3184
type: UnificationXref
id: 1629732
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629732

UnificationXref1720
type: UnificationXref
id: P0CX33
db: UniProt

UniProt:P32353
type: ProteinReference
xref: UnificationXref3804
organism: BioSource1

UnificationXref3185
type: UnificationXref
id: REACT_152401
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152401.1

UnificationXref1721
type: UnificationXref
id: 3666995
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666995

UniProt:P32354
type: ProteinReference
xref: UnificationXref245
organism: BioSource1

UnificationXref3186
type: UnificationXref
id: CHEBI:62924
db: ChEBI

UnificationXref3187
type: UnificationXref
id: 1629766
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629766

UnificationXref1738
type: UnificationXref
id: 3667029
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667029

UnificationXref1737
type: UnificationXref
id: 3667028
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667028

UnificationXref1739
type: UnificationXref
id: P38711
db: UniProt

UniProt:Q07949
type: ProteinReference
xref: UnificationXref9829
organism: BioSource1

1D-myo-Inositol 3-phosphate [ChEBI:814]
type: SmallMoleculeReference
name: 1D-myo-Inositol 3-phosphate
name: Inositol 3-monophosphate
name: D-myo-Inositol 3-monophosphate
name: Inositol 3-phosphate
name: D-myo-Inositol 3-phosphate
name: myo-Inositol 3-monophosphate
name: myo-Inositol 3-phosphate
name: 1D-myo-Inositol 3-monophosphate
xref: UnificationXref3236

http://identifiers.org/pubmed/16176984
type: PublicationXref
id: 16176984
author: Flachsova, E
author: Lee, DS
author: Bodnarova, M
author: Raman, CS
author: Martasek, P
author: Demeler, B
db: Pubmed
title: Structural basis of hereditary coproporphyria
source: Proc Natl Acad Sci U S A 102:14232-7
year: 2005

UniProt:P32347
type: ProteinReference
xref: UnificationXref6341
organism: BioSource1

UnificationXref1733
type: UnificationXref
id: 3666894
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666894

UnificationXref1734
type: UnificationXref
id: P0CX38
db: UniProt

UnificationXref3199
type: UnificationXref
id: CHEBI:16595
db: ChEBI

UnificationXref1735
type: UnificationXref
id: 3667026
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667026

UnificationXref1736
type: UnificationXref
id: P0CX37
db: UniProt

UnificationXref3197
type: UnificationXref
id: 3673616
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673616

UnificationXref3198
type: UnificationXref
id: REACT_153757
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153757.3

UnificationXref1730
type: UnificationXref
id: 3666891
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666891

UnificationXref3195
type: UnificationXref
id: 3672692
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672692

UnificationXref1731
type: UnificationXref
id: P0CX56
db: UniProt

UnificationXref3196
type: UnificationXref
id: REACT_153040
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153040.3

UnificationXref1732
type: UnificationXref
id: 3666893
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666893

7alpha,26-dihydroxy-5beta-cholestan-3-one [ChEBI:48778]
type: SmallMoleculeReference
name: 7alpha,26-dihydroxy-5beta-cholestan-3-one
name: 5beta-cholestan-7alpha,27-diol-3-one
name: 5beta-cholestan-7alpha,26-diol-3-one
xref: UnificationXref3979

UniProt:P32327
type: ProteinReference
xref: UnificationXref2722
organism: BioSource1

UniProt:P32324
type: ProteinReference
xref: UnificationXref7813
organism: BioSource1

http://identifiers.org/pubmed/11057895
type: PublicationXref
id: 11057895
author: Schlessinger, J
db: Pubmed
title: Cell signaling by receptor tyrosine kinases
source: Cell 103:211-25
year: 2000

http://identifiers.org/pubmed/19933148
type: PublicationXref
id: 19933148
author: Espenshade, PJ
author: Osborne, TF
db: Pubmed
title: Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been
source: Genes Dev 23:2578-91
year: 2009

http://identifiers.org/pubmed/17010132
type: PublicationXref
id: 17010132
author: Koek, W
author: Strong, R
author: Ran, Q
author: Fernández, E
author: Gerhardt, GA
author: France, CP
db: Pubmed
title: Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout mice
source: Alcohol Clin Exp Res 30:1650-8
year: 2006

Class I MHC mediated antigen processing & presentation
type: Pathway
data source: Provenance1
pathway component: REACT 141384.5
pathway component: REACT 140987.5
evidence: Evidence1305
xref: RelationshipXref1110
xref: UnificationXref9169
xref: UnificationXref9170
pathway order: PathwayStep1303
pathway order: PathwayStep1308
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/3098894
type: PublicationXref
id: 3098894
author: Wang, HM
author: Kato, K
author: Smith, KA
author: Teshigawara, K
db: Pubmed
title: Interleukin 2 high-affinity receptor expression requires two distinct binding proteins
source: J Exp Med 165:223-38
year: 1987

PublicationXref1874
type: PublicationXref
author: Choe, J
author: Park, H
author: Bochkarev, A
author: Sundstrom, M
author: Edwards, AM
author: Arrowsmith, CH
author: Atanassova, A
title: AK3L1 - Human Adenylate Kinase 3-Like 1
url: http://www.thesgc.org/structures/structure_description/1ZD8/

http://identifiers.org/pubmed/3399500
type: PublicationXref
id: 3399500
author: Seino, S
author: Bell, GI
author: Byers, MG
author: Shows, TB
author: Imura, H
author: Eddy, RL
author: Fukushima, Y
author: Seino, Y
author: Fukumoto, H
db: Pubmed
title: Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein
source: Proc Natl Acad Sci U S A 85:5434-8
year: 1988

RNA Polymerase III Chain Elongation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction589
evidence: Evidence894
xref: UnificationXref7115
xref: UnificationXref7114
xref: RelationshipXref891
pathway order: PathwayStep895
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/16704971
type: PublicationXref
id: 16704971
author: Harayama, T
author: Hishikawa, D
author: Suwabe, A
author: Ogasawara, R
author: Shimizu, T
author: Taguchi, R
author: Nakanishi, H
author: Shindou, H
db: Pubmed
title: Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production
source: J Biol Chem 281:20140-7
year: 2006

http://identifiers.org/pubmed/8987985
type: PublicationXref
id: 8987985
author: Gould, GW
author: Arbuckle, MI
author: Porter, LM
author: Kane, S
author: Seatter, MJ
db: Pubmed
title: Structure-function analysis of liver-type (GLUT2) and brain-type (GLUT3) glucose transporters: expression of chimeric transporters in Xenopus oocytes suggests an important role for putative transmembrane helix 7 in determining substrate selectivity
source: Biochemistry 35:16519-27
year: 1996

http://identifiers.org/pubmed/16987893
type: PublicationXref
id: 16987893
author: Takahashi, JS
author: Ko, CH
db: Pubmed
title: Molecular components of the mammalian circadian clock
source: Hum Mol Genet 15:R271-7
year: 2006

http://identifiers.org/pubmed/18589439
type: PublicationXref
id: 18589439
author: Perry, JJ
author: Widmer, H
author: Kuhn, P
author: Weckbecker, G
author: Ramage, P
author: Bokoch, GM
author: Hura, GL
author: Streiff, M
author: Zhang, H
author: Tainer, JA
author: Mathews, II
author: Chrencik, JE
author: Foster, SA
author: Brooun, A
db: Pubmed
title: Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1
source: J Mol Biol 380:828-43
year: 2008

http://identifiers.org/pubmed/11598127
type: PublicationXref
id: 11598127
author: Bembenek, J
author: Yu, H
db: Pubmed
title: Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a
source: J Biol Chem 276:48237-42
year: 2001

http://identifiers.org/pubmed/16908340
type: PublicationXref
id: 16908340
author: Nevo, Y
author: Nelson, N
db: Pubmed
title: The NRAMP family of metal-ion transporters
source: Biochim Biophys Acta 1763:609-20
year: 2006

PublicationXref1853
type: PublicationXref
author: Krauss, G
title: Biochemistry of signal transduction and regulation
source: 259
year: 2003

UniProt:P26188
type: ProteinReference
xref: UnificationXref8888
organism: BioSource1

http://identifiers.org/pubmed/15474001
type: PublicationXref
id: 15474001
author: Woscholski, R
author: Mitchell, CA
author: Nussbaum, R
author: Wise, HM
author: Schmid, AC
db: Pubmed
title: Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation
source: FEBS Lett 576:9-13
year: 2004

PublicationXref1846
type: PublicationXref
author: Dekker, L
title: Protein Kinase C
year: 2004

http://identifiers.org/pubmed/17553782
type: PublicationXref
id: 17553782
author: Chacinska, A
author: Guiard, B
author: Milenkovic, D
author: Schulze-Specking, A
author: Gabriel, K
author: Pfanner, N
db: Pubmed
title: Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria: site-specific recognition of cysteine residues by the intermembrane space receptor Mia40
source: J Biol Chem 282:22472-80
year: 2007

http://identifiers.org/pubmed/18781350
type: PublicationXref
id: 18781350
author: Zou, J
author: Wang, L
author: Chen, Q
author: Kazachkov, M
db: Pubmed
title: Substrate preferences of a lysophosphatidylcholine acyltransferase highlight its role in phospholipid remodeling
source: Lipids 43:895-902
year: 2008

UniProt:P38886
type: ProteinReference
xref: UnificationXref1114
organism: BioSource1

UniProt:P38888
type: ProteinReference
xref: UnificationXref9750
organism: BioSource1

http://identifiers.org/pubmed/9102399
type: PublicationXref
id: 9102399
author: Degerman, E
author: Manganiello, VC
author: Belfrage, P
db: Pubmed
title: Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)
source: J Biol Chem 272:6823-6
year: 1997

http://identifiers.org/pubmed/3057511
type: PublicationXref
id: 3057511
author: Vance, DE
author: Ridgway, ND
db: Pubmed
title: The methylation of phosphatidylethanolamine
source: Prog Lipid Res 27:61-79
year: 1988

UniProt:P38891
type: ProteinReference
xref: UnificationXref5873
organism: BioSource1

http://identifiers.org/pubmed/11027599
type: PublicationXref
id: 11027599
author: Amiry-Moghaddam, M
author: Frøkiaer, J
author: Kwon, T
author: Nielsen, S
author: Vajda, Z
author: Elkjaer, M
author: Nejsum, LN
author: Jensen, UB
db: Pubmed
title: Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain
source: Biochem Biophys Res Commun 276:1118-28
year: 2000

UnificationXref8525
type: UnificationXref
id: REACT_94604
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94604.9

SequenceSite1825
type: SequenceSite
position status: EQUAL
sequence position: 552

UnificationXref8526
type: UnificationXref
id: 3673165
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673165

SequenceSite1826
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8523
type: UnificationXref
id: REACT_141861
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141861.5

SequenceSite1827
type: SequenceSite
position status: EQUAL
sequence position: 380

UnificationXref8524
type: UnificationXref
id: 3673164
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673164

SequenceSite1828
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8521
type: UnificationXref
id: REACT_134837
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134837.5

SequenceSite1821
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8522
type: UnificationXref
id: 3667973
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3667973

SequenceSite1822
type: SequenceSite
position status: EQUAL
sequence position: 562

SequenceSite1823
type: SequenceSite
position status: EQUAL
sequence position: 371

UnificationXref8520
type: UnificationXref
id: 3673216
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673216

SequenceSite1824
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/17651088
type: PublicationXref
id: 17651088
author: Wandinger-Ness, A
author: Cao, C
author: Backer, JM
author: Stein, MP
author: Laporte, J
db: Pubmed
title: Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes
source: Traffic 8:1052-67
year: 2007

SequenceSite1820
type: SequenceSite
position status: EQUAL
sequence position: 379

UnificationXref8529
type: UnificationXref
id: REACT_156217
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156217.3

UnificationXref8527
type: UnificationXref
id: REACT_33791
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33791.10

UnificationXref8528
type: UnificationXref
id: 3669352
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669352

SequenceSite1829
type: SequenceSite
position status: EQUAL
sequence position: 380

UnificationXref8512
type: UnificationXref
id: 3673213
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673213

SequenceSite1838
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/18694939
type: PublicationXref
id: 18694939
author: Siniossoglou, S
author: Rochford, JJ
author: Carman, GM
author: Grimsey, N
author: Han, GS
author: O'Hara, L
db: Pubmed
title: Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2
source: J Biol Chem 283:29166-74
year: 2008

UnificationXref8513
type: UnificationXref
id: REACT_101713
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101713.9

SequenceSite1839
type: SequenceSite
position status: EQUAL
sequence position: 392

UnificationXref8514
type: UnificationXref
id: 3673226
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673226

SequenceSite1836
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q12001
type: ProteinReference
xref: UnificationXref9669
organism: BioSource1

UnificationXref8515
type: UnificationXref
id: REACT_126124
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126124.5

SequenceSite1837
type: SequenceSite
position status: EQUAL
sequence position: 394

SequenceSite1834
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1835
type: SequenceSite
position status: EQUAL
sequence position: 394

UnificationXref8510
type: UnificationXref
id: 3673212
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673212

SequenceSite1832
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8511
type: UnificationXref
id: REACT_85750
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85750.9

SequenceSite1833
type: SequenceSite
position status: EQUAL
sequence position: 383

SequenceSite1830
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1831
type: SequenceSite
position status: EQUAL
sequence position: 383

UniProt:Q12004
type: ProteinReference
xref: UnificationXref2291
organism: BioSource1

UnificationXref8516
type: UnificationXref
id: 3673214
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673214

UnificationXref8517
type: UnificationXref
id: REACT_146727
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146727.5

UnificationXref8518
type: UnificationXref
id: 3673215
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673215

UnificationXref8519
type: UnificationXref
id: REACT_97171
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97171.9

Fibroblast Growth Factor Receptor (FGFR) signaling
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction103
pathway component: Downstream signaling of activated FGFR
evidence: Evidence214
xref: UnificationXref2147
xref: RelationshipXref120
xref: UnificationXref2146
pathway order: PathwayStep214
pathway order: PathwayStep215
display name: Signaling by FGFR
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

DNA2
type: ProteinReference
name: UniProt:P38859 DNA2
name: YHR164C
xref: UnificationXref6646
comment: FUNCTION Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is atypical: it cannot load onto its tracking strand internally and has an absolute free 5'-end requirement. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.CATALYTIC ACTIVITY ATP + H(2)O = ADP + phosphate.COFACTOR Binds 1 4Fe-4S cluster.PTM Phosphorylated at Ser-17 and Ser-237 by CDK1 in response to DNA damage, leading to promote recruitment to double-strand break (DSB) sites and DNA resection.SIMILARITY Belongs to the DNA2/NAM7 helicase family.
organism: BioSource1

UniProt:P38857
type: ProteinReference
xref: UnificationXref4831
organism: BioSource1

UniProt:P38858
type: ProteinReference
xref: UnificationXref2988
organism: BioSource1

UnificationXref8500
type: UnificationXref
id: 3673366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673366

SequenceSite1800
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1801
type: SequenceSite
position status: EQUAL
sequence position: 660

SequenceSite1802
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8503
type: UnificationXref
id: REACT_103699
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103699.9

SequenceSite1803
type: SequenceSite
position status: EQUAL
sequence position: 160

UnificationXref8504
type: UnificationXref
id: CHEBI:16618
db: ChEBI

SequenceSite1804
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref8501
type: UnificationXref
id: REACT_103104
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103104.9

SequenceSite1805
type: SequenceSite
position status: EQUAL
sequence position: 611

UnificationXref8502
type: UnificationXref
id: 3673349
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673349

SequenceSite1806
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8507
type: UnificationXref
id: 3668342
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668342

UnificationXref8508
type: UnificationXref
id: 3668343
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3668343

UnificationXref8505
type: UnificationXref
id: 38117
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=38117

UnificationXref8506
type: UnificationXref
id: REACT_5133
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5133.3

UnificationXref8509
type: UnificationXref
id: REACT_146255
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146255.5

Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction700
pathway component: BiochemicalReaction702
pathway component: BiochemicalReaction704
pathway component: BiochemicalReaction703
pathway component: BiochemicalReaction701
pathway component: BiochemicalReaction699
evidence: Evidence1082
xref: UnificationXref8294
xref: UnificationXref8293
pathway order: PathwayStep1086
pathway order: PathwayStep1087
pathway order: PathwayStep1085
pathway order: PathwayStep1089
pathway order: PathwayStep1088
pathway order: PathwayStep1084
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite1808
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1807
type: SequenceSite
position status: EQUAL
sequence position: 1531

COPII (Coat Protein 2) Mediated Vesicle Transport
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction84
pathway component: BiochemicalReaction86
pathway component: BiochemicalReaction83
pathway component: BiochemicalReaction85
pathway component: BiochemicalReaction82
evidence: Evidence165
xref: UnificationXref1840
xref: RelationshipXref96
xref: UnificationXref1839
pathway order: PathwayStep163
pathway order: PathwayStep165
pathway order: PathwayStep167
pathway order: PathwayStep166
pathway order: PathwayStep164
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite1809
type: SequenceSite
position status: EQUAL
sequence position: 1531

UniProt:P38865
type: ProteinReference
xref: UnificationXref8207
organism: BioSource1

SequenceSite1812
type: SequenceSite
position status: EQUAL
sequence position: 381

SequenceSite1813
type: SequenceSite
position status: EQUAL
sequence position: 569

SequenceSite1810
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1811
type: SequenceSite
position status: EQUAL
sequence position: 380

SequenceSite1816
type: SequenceSite
position status: EQUAL
sequence position: 388

SequenceSite1817
type: SequenceSite
position status: EQUAL
sequence position: 586

Bile acid and bile salt metabolism
type: Pathway
data source: Provenance1
pathway component: Synthesis of bile acids and bile salts
pathway component: REACT 113858.8
evidence: Evidence474
xref: UnificationXref4027
xref: RelationshipXref372
xref: UnificationXref4026
pathway order: PathwayStep471
pathway order: PathwayStep469
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite1814
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1815
type: SequenceSite
position status: EQUAL
sequence position: 387

http://identifiers.org/pubmed/8104191
type: PublicationXref
id: 8104191
author: Vainberg, IE
author: Chow, RL
author: Melki, R
author: Cowan, NJ
db: Pubmed
title: Chaperonin-mediated folding of vertebrate actin-related protein and gamma-tubulin
source: J Cell Biol 122:1301-10
year: 1993

http://identifiers.org/pubmed/11084340
type: PublicationXref
id: 11084340
author: Spaargaren, C
author: Malecz, N
author: Chuang, Y
author: Symons, M
author: McCabe, PC
author: Qiu, R
db: Pubmed
title: Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis
source: Curr Biol 10:1383-6
year: 2000

UniProt:P38873
type: ProteinReference
xref: UnificationXref8470
organism: BioSource1

SequenceSite1819
type: SequenceSite
position status: EQUAL
sequence position: 473

SequenceSite1818
type: SequenceSite
position status: EQUAL
sequence position: 1

GRB2 events in EGFR signaling
type: Pathway
data source: Provenance1
pathway component: REACT 107261.9
evidence: Evidence199
xref: UnificationXref2072
xref: UnificationXref2073
pathway order: PathwayStep200
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8570
type: UnificationXref
id: REACT_161753
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161753.2

UnificationXref8571
type: UnificationXref
id: 3673231
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673231

iron (ferrous)
type: SmallMoleculeReference
name: iron (ferrous) [ChEBI:18248]
name: Fe2+
name: Fe(II)
name: Fe++
xref: UnificationXref4000

UnificationXref8572
type: UnificationXref
id: REACT_100846
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100846.9

UnificationXref8573
type: UnificationXref
id: 3673233
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673233

UnificationXref1893
type: UnificationXref
id: P39929
db: UniProt

UnificationXref1892
type: UnificationXref
id: 3671620
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671620

UnificationXref1891
type: UnificationXref
id: Q04272
db: UniProt

UnificationXref1890
type: UnificationXref
id: 3671609
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671609

UnificationXref1897
type: UnificationXref
id: 3671616
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671616

UnificationXref1896
type: UnificationXref
id: 3671615
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671615

UnificationXref1895
type: UnificationXref
id: 3671614
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671614

UnificationXref1894
type: UnificationXref
id: 3671613
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671613

http://identifiers.org/pubmed/9382095
type: PublicationXref
id: 9382095
author: Jin, BY
author: Taketo, A
author: Shigematsu, Y
author: Nakai, A
author: Koga, J-i
author: Yamamoto, Y
author: Mizunuma, H
author: Inuzuka, M
author: Sudo, M
author: Kaji, S
author: Fujisawa, K
author: Kikawa, Y
author: Hata, I
author: Mayumi, M
db: Pubmed
title: Identification of genetic mutations in Japanese patients with fructose-1,6-bisphosphatase deficiency
source: Am J Hum Genet 61:852-861
year: 1997

UnificationXref1899
type: UnificationXref
id: 3671625
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671625

UnificationXref1898
type: UnificationXref
id: 3671622
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671622

SequenceSite1864
type: SequenceSite
position status: EQUAL
sequence position: 371

SequenceSite1863
type: SequenceSite
position status: EQUAL
sequence position: 35

SequenceSite1862
type: SequenceSite
position status: EQUAL
sequence position: 458

SequenceSite1861
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite1860
type: SequenceSite
position status: EQUAL
sequence position: 458

http://identifiers.org/pubmed/9538690
type: PublicationXref
id: 9538690
author: Wilkes, D
author: Malcolm, S
author: Burke, D
author: Blundell, TL
db: Pubmed
title: Fibroblast growth factor receptors: lessons from the genes
source: Trends Biochem Sci 23:59-62
year: 1998

UnificationXref8568
type: UnificationXref
id: REACT_137601
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137601.5

UnificationXref8567
type: UnificationXref
id: 3673227
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673227

UnificationXref8569
type: UnificationXref
id: 3673241
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673241

SequenceSite1869
type: SequenceSite
position status: EQUAL
sequence position: 20

UnificationXref8564
type: UnificationXref
id: REACT_155795
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155795.3

SequenceSite1868
type: SequenceSite
position status: EQUAL
sequence position: 369

UnificationXref8563
type: UnificationXref
id: 3673402
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673402

SequenceSite1867
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q12030
type: ProteinReference
xref: UnificationXref7151
organism: BioSource1

UnificationXref8566
type: UnificationXref
id: REACT_98121
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98121.9

SequenceSite1866
type: SequenceSite
position status: EQUAL
sequence position: 479

UnificationXref8565
type: UnificationXref
id: 3673397
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673397

SequenceSite1865
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8561
type: UnificationXref
id: 3673401
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673401

UnificationXref8562
type: UnificationXref
id: REACT_157548
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157548.3

UnificationXref8560
type: UnificationXref
id: REACT_156364
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156364.3

UnificationXref1880
type: UnificationXref
id: Q06696
db: UniProt

UnificationXref1882
type: UnificationXref
id: Q12483
db: UniProt

UnificationXref1881
type: UnificationXref
id: 3671637
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671637

UnificationXref1884
type: UnificationXref
id: 3671638
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671638

http://identifiers.org/pubmed/15175331
type: PublicationXref
id: 15175331
author: Holden, HM
author: Thoden, JB
author: Watson, AL
author: Ross, KL
author: Schulz, JM
author: Sanders, R
author: Fridovich-Keil, JL
db: Pubmed
title: Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase
source: J Biol Chem 279:32796-803
year: 2004

Zymosterol [ChEBI:10131]
type: SmallMoleculeReference
name: Zymosterol
name: delta8,24-Cholestadien-3beta-ol
xref: UnificationXref3793

UnificationXref1883
type: UnificationXref
id: 3671629
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671629

http://identifiers.org/pubmed/15949434
type: PublicationXref
id: 15949434
author: Hoyt, MA
author: Owens, TJ
db: Pubmed
title: The D box asserts itself
source: Mol Cell 18:611-2
year: 2005

UnificationXref1886
type: UnificationXref
id: 3671621
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671621

UnificationXref1885
type: UnificationXref
id: 3671639
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671639

UnificationXref1888
type: UnificationXref
id: 3671605
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671605

UnificationXref1887
type: UnificationXref
id: P36108
db: UniProt

UnificationXref1889
type: UnificationXref
id: P36095
db: UniProt

SequenceSite1873
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1872
type: SequenceSite
position status: EQUAL
sequence position: 233

SequenceSite1875
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1874
type: SequenceSite
position status: EQUAL
sequence position: 672

http://identifiers.org/pubmed/14718169
type: PublicationXref
id: 14718169
author: Roe, SM
author: Meyer, P
author: Ali, MM
author: Piper, PW
author: Prodromou, C
author: Vaughan, CK
author: Pearl, LH
author: Panaretou, B
db: Pubmed
title: The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
source: Cell 116:87-98
year: 2004

SequenceSite1871
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1870
type: SequenceSite
position status: EQUAL
sequence position: 307

UnificationXref8559
type: UnificationXref
id: 3669393
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669393

UnificationXref8558
type: UnificationXref
id: 3669391
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669391

UnificationXref8557
type: UnificationXref
id: 3669390
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669390

UnificationXref8556
type: UnificationXref
id: P53046
db: UniProt

UnificationXref8555
type: UnificationXref
id: 3669386
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669386

SequenceSite1877
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8554
type: UnificationXref
id: P51862
db: UniProt

SequenceSite1876
type: SequenceSite
position status: EQUAL
sequence position: 672

UnificationXref8553
type: UnificationXref
id: 3669382
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669382

SequenceSite1879
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8552
type: UnificationXref
id: REACT_3646
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3646.1

SequenceSite1878
type: SequenceSite
position status: EQUAL
sequence position: 2458

UnificationXref1871
type: UnificationXref
id: REACT_156591
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156591.3

UnificationXref1870
type: UnificationXref
id: 3673461
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673461

Inositol 1,3,4-trisphosphate
type: SmallMoleculeReference
name: D-myo-Inositol 1,3,4-trisphosphate
name: 1D-myo-Inositol 1,3,4-trisphosphate [ChEBI:810]
name: 1D-myo-Inositol 1,3,4-trisphosphate
xref: UnificationXref3076

UnificationXref8550
type: UnificationXref
id: 3669381
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669381

UnificationXref8551
type: UnificationXref
id: 113572
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113572

http://identifiers.org/pubmed/22078883
type: PublicationXref
id: 22078883
author: Barresi, S
author: Barton, GM
author: Marek, LR
author: Ostuni, R
author: Granucci, Francesca
author: Barbalat, R
author: Kagan, JC
author: Zanoni, Ivan
db: Pubmed
title: CD14 controls the LPS-induced endocytosis of Toll-like receptor 4
source: Cell 147:868-80
year: 2011

UnificationXref1879
type: UnificationXref
id: 3671633
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671633

UnificationXref1878
type: UnificationXref
id: P47142
db: UniProt

UnificationXref1877
type: UnificationXref
id: 3671624
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671624

UnificationXref1876
type: UnificationXref
id: REACT_27417
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27417.2

UnificationXref1875
type: UnificationXref
id: 917716
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=917716

http://identifiers.org/pubmed/9895304
type: PublicationXref
id: 9895304
author: Gray, A
author: Alessi, DR
author: Cohen, P
author: Walker, KS
author: Currie, RA
author: Casamayor, A
author: Deak, M
author: Downes, CP
author: Lucocq, J
db: Pubmed
title: Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
source: Biochem J 337:575-83
year: 1999

UnificationXref1874
type: UnificationXref
id: CHEBI:16618
db: ChEBI

UnificationXref1873
type: UnificationXref
id: 3671623
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3671623

UnificationXref1872
type: UnificationXref
id: GO:0010008
db: GENE ONTOLOGY

UnificationXref8549
type: UnificationXref
id: 3669380
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669380

SequenceSite1842
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1841
type: SequenceSite
position status: EQUAL
sequence position: 392

SequenceSite1840
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8542
type: UnificationXref
id: REACT_90380
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90380.9

SequenceSite1846
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8541
type: UnificationXref
id: 3669359
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669359

SequenceSite1845
type: SequenceSite
position status: EQUAL
sequence position: 384

UnificationXref8544
type: UnificationXref
id: REACT_94832
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94832.9

SequenceSite1844
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8543
type: UnificationXref
id: 3673398
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673398

SequenceSite1843
type: SequenceSite
position status: EQUAL
sequence position: 384

UnificationXref8546
type: UnificationXref
id: REACT_4514
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4514.1

UnificationXref8545
type: UnificationXref
id: 114549
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114549

SequenceSite1849
type: SequenceSite
position status: EQUAL
sequence position: 441

UnificationXref8548
type: UnificationXref
id: 3669379
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669379

SequenceSite1848
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8547
type: UnificationXref
id: 3669375
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669375

SequenceSite1847
type: SequenceSite
position status: EQUAL
sequence position: 441

UnificationXref1860
type: UnificationXref
id: 3673422
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673422

UnificationXref8540
type: UnificationXref
id: REACT_14065
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14065.2

UnificationXref1866
type: UnificationXref
id: 3670213
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670213

UnificationXref1865
type: UnificationXref
id: 3670212
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670212

UnificationXref1868
type: UnificationXref
id: 3673460
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673460

UnificationXref1867
type: UnificationXref
id: REACT_159209
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159209.3

UnificationXref1862
type: UnificationXref
id: 3670209
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670209

UnificationXref1861
type: UnificationXref
id: REACT_153926
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153926.3

UnificationXref1864
type: UnificationXref
id: 3670211
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670211

UnificationXref1863
type: UnificationXref
id: 3670210
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3670210

UnificationXref8539
type: UnificationXref
id: 194358
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194358

UnificationXref8538
type: UnificationXref
id: REACT_14441
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14441.2

http://identifiers.org/pubmed/12947415
type: PublicationXref
id: 12947415
author: Mühlenhoff, Ulrich
author: Lill, R
author: Gerber, Jana
db: Pubmed
title: An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1
source: EMBO Rep. 4:906-11
year: 2003

UnificationXref1869
type: UnificationXref
id: REACT_158211
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158211.3

SequenceSite1851
type: SequenceSite
position status: EQUAL
sequence position: 399

SequenceSite1850
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/12587671
type: PublicationXref
id: 12587671
author: Ditlevsen, DK
author: Berezin, V
author: Bock, E
author: Povlsen, GK
db: Pubmed
title: Intracellular signaling by the neural cell adhesion molecule
source: Neurochem Res 28:127-41
year: 2003

SequenceSite1853
type: SequenceSite
position status: EQUAL
sequence position: 399

SequenceSite1852
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8533
type: UnificationXref
id: REACT_157353
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157353.3

SequenceSite1855
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8532
type: UnificationXref
id: 3673396
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673396

SequenceSite1854
type: SequenceSite
position status: EQUAL
sequence position: 353

UnificationXref8531
type: UnificationXref
id: REACT_157329
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157329.3

SequenceSite1857
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8530
type: UnificationXref
id: 3673395
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673395

SequenceSite1856
type: SequenceSite
position status: EQUAL
sequence position: 568

UnificationXref8537
type: UnificationXref
id: 194377
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194377

SequenceSite1859
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref8536
type: UnificationXref
id: CHEBI:52639
db: ChEBI

SequenceSite1858
type: SequenceSite
position status: EQUAL
sequence position: 423

UniProt:Q12021
type: ProteinReference
xref: UnificationXref9032
organism: BioSource1

UniProt:Q02753
type: ProteinReference
xref: UnificationXref1406
organism: BioSource1

UnificationXref8535
type: UnificationXref
id: REACT_13988
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13988.2

UnificationXref8534
type: UnificationXref
id: 194351
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194351

MRN complex relocalizes to nuclear foci
type: Pathway
data source: Provenance1
pathway component: REACT 98075.9
evidence: Evidence1241
xref: UnificationXref8928
xref: UnificationXref8927
pathway order: PathwayStep1246
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3110
type: UnificationXref
id: CHEBI:30164
db: ChEBI

UnificationXref3111
type: UnificationXref
id: 2023940
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023940

UnificationXref3112
type: UnificationXref
id: REACT_151792
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151792.1

UnificationXref3113
type: UnificationXref
id: 3672659
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672659

UnificationXref3114
type: UnificationXref
id: REACT_153723
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153723.3

UnificationXref3115
type: UnificationXref
id: CHEBI:62985
db: ChEBI

UnificationXref3116
type: UnificationXref
id: 2023941
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023941

UnificationXref3117
type: UnificationXref
id: REACT_151655
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151655.1

UnificationXref3118
type: UnificationXref
id: 3672669
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672669

UnificationXref3119
type: UnificationXref
id: REACT_158812
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158812.3

http://identifiers.org/pubmed/10438470
type: PublicationXref
id: 10438470
author: Iizuka, M
author: Stillman, B
db: Pubmed
title: Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein.
source: J Biol Chem 274:23027-34
year: 1999

UniProt:Q12074
type: ProteinReference
xref: UnificationXref6134
organism: BioSource1

UnificationXref3102
type: UnificationXref
id: CHEBI:62931
db: ChEBI

UnificationXref3103
type: UnificationXref
id: 2023948
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023948

UnificationXref3100
type: UnificationXref
id: 3672651
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672651

UnificationXref3101
type: UnificationXref
id: REACT_154417
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154417.3

UnificationXref3106
type: UnificationXref
id: REACT_155494
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155494.3

UnificationXref3107
type: UnificationXref
id: CHEBI:17401
db: ChEBI

http://identifiers.org/pubmed/11564765
type: PublicationXref
id: 11564765
author: Klinman, DM
author: Ishii, KJ
author: Gursel, I
author: Takeshita, F
author: Gursel, M
author: Leifer, CA
author: Takeshita, S
db: Pubmed
title: Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells
source: J Immunol 167:3555-8
year: 2001

UnificationXref3104
type: UnificationXref
id: REACT_151435
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151435.1

UnificationXref3105
type: UnificationXref
id: 3672673
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3672673

UnificationXref3108
type: UnificationXref
id: 2023929
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023929

UnificationXref3109
type: UnificationXref
id: REACT_150776
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150776.1

YPL063W
type: ProteinReference
name: UniProt:Q02776 TIM50
name: TIM50
xref: UnificationXref809
comment: FUNCTION Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex. Does not act as a structural subunit of the TIM23 complex but plays a dynamic role in protein import. Has no phosphatase activity.SUBUNIT Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts directly with TIM23. Interacts with preproteins in transit.DOMAIN The mitochondrial intermembrane region is required for generation but not stabilization of the TIM23 complex.DOMAIN The FCP1 homology domain does not contain the canonical D-x-D-x-[TV] active site, suggesting that it probably does not display phosphatase activity.MISCELLANEOUS Present with 2400 molecules/cell in log phase SD medium.SIMILARITY Belongs to the TIM50 family.SIMILARITY Contains 1 FCP1 homology domain.
organism: BioSource1

UnificationXref8598
type: UnificationXref
id: 3673260
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673260

UnificationXref8599
type: UnificationXref
id: REACT_118186
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118186.7

UnificationXref8596
type: UnificationXref
id: 3673255
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673255

UnificationXref8597
type: UnificationXref
id: REACT_137738
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137738.5

UDP-D-xylose
type: SmallMoleculeReference
name: UDP-D-xylose [ChEBI:9813]
name: UDPxylose
name: UDP-alpha-D-xylose
xref: UnificationXref8304

UnificationXref8591
type: UnificationXref
id: REACT_161727
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161727.2

UnificationXref8590
type: UnificationXref
id: 3673239
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673239

UnificationXref8593
type: UnificationXref
id: REACT_82479
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82479.9

Clearance of serotonin
type: Pathway
data source: Provenance1
name: Serotonin clearance from the synaptic cleft
pathway component: REACT 152666.3
evidence: Evidence59
xref: UnificationXref506
xref: UnificationXref507
pathway order: PathwayStep52
display name: Clearance of seratonin
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8592
type: UnificationXref
id: 3673240
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673240

UnificationXref8595
type: UnificationXref
id: REACT_115134
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115134.8

UnificationXref8594
type: UnificationXref
id: 3673259
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673259

UniProt:Q12051
type: ProteinReference
xref: UnificationXref3684
organism: BioSource1

UnificationXref8585
type: UnificationXref
id: REACT_83574
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83574.9

SequenceSite1889
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref8586
type: UnificationXref
id: 3673229
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673229

UnificationXref8587
type: UnificationXref
id: REACT_83040
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83040.9

SequenceSite1887
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8588
type: UnificationXref
id: 3673230
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673230

SequenceSite1888
type: SequenceSite
position status: EQUAL
sequence position: 127

UnificationXref8589
type: UnificationXref
id: REACT_90598
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90598.9

UniProt:Q12056
type: ProteinReference
xref: UnificationXref6540
organism: BioSource1

SequenceSite1881
type: SequenceSite
position status: EQUAL
sequence position: 1

Methionine salvage pathway
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction526
pathway component: BiochemicalReaction530
pathway component: BiochemicalReaction531
pathway component: BiochemicalReaction529
pathway component: BiochemicalReaction527
pathway component: BiochemicalReaction528
pathway component: BiochemicalReaction525
evidence: Evidence797
xref: UnificationXref6188
xref: RelationshipXref783
xref: UnificationXref6189
pathway order: PathwayStep794
pathway order: PathwayStep797
pathway order: PathwayStep795
pathway order: PathwayStep793
pathway order: PathwayStep796
pathway order: PathwayStep798
pathway order: PathwayStep792
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite1882
type: SequenceSite
position status: EQUAL
sequence position: 250

http://identifiers.org/pubmed/3871768
type: PublicationXref
id: 3871768
author: Villar, E
author: Schuster, B
author: Schirch, V
author: Peterson, D
db: Pubmed
title: C1-Tetrahydrofolate synthase from rabbit liver. Structural and kinetic properties of the enzyme and its two domains.
source: J Biol Chem 260:2245-52
year: 1985

SequenceSite1880
type: SequenceSite
position status: EQUAL
sequence position: 2458

SequenceSite1885
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1886
type: SequenceSite
position status: EQUAL
sequence position: 127

SequenceSite1883
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/10518023
type: PublicationXref
id: 10518023
author: Collard, F
author: Veiga-da-Cunha, M
author: Gerin, I
author: Van Schaftingen, E
author: Collet, JF
db: Pubmed
title: Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1)
source: FEBS Lett 459:223-6
year: 1999

SequenceSite1884
type: SequenceSite
position status: EQUAL
sequence position: 187

Dolichol [ChEBI:4686]
type: SmallMoleculeReference
name: Dolichol
xref: UnificationXref9486

http://identifiers.org/pubmed/17352659
type: PublicationXref
id: 17352659
author: Imam, JS
author: Chang, YF
author: Wilkinson, MF
db: Pubmed
title: The nonsense-mediated decay RNA surveillance pathway
source: Annu Rev Biochem 76:51-74
year: 2007

UnificationXref8580
type: UnificationXref
id: REACT_110304
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_110304.9

Immune System signaling
type: Pathway
data source: Provenance1
name: Signaling in Immune system
pathway component: REACT 145247.5
pathway component: REACT 146705.5
pathway component: REACT 100341.9
evidence: Evidence1353
xref: UnificationXref9339
xref: UnificationXref9340
pathway order: PathwayStep1356
pathway order: PathwayStep1353
pathway order: PathwayStep1310
display name: Immune System
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref8584
type: UnificationXref
id: 3673428
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673428

UnificationXref8583
type: UnificationXref
id: REACT_85879
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85879.9

UnificationXref8582
type: UnificationXref
id: 3669846
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669846

UnificationXref8581
type: UnificationXref
id: 3669845
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669845

UnificationXref8576
type: UnificationXref
id: REACT_97271
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97271.9

SequenceSite1898
type: SequenceSite
position status: EQUAL
sequence position: 501

UnificationXref8577
type: UnificationXref
id: 3673228
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673228

SequenceSite1899
type: SequenceSite
position status: EQUAL
sequence position: 132

UnificationXref8574
type: UnificationXref
id: REACT_84327
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_84327.9

UnificationXref8575
type: UnificationXref
id: 3673232
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673232

UnificationXref8578
type: UnificationXref
id: REACT_90182
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90182.9

UnificationXref8579
type: UnificationXref
id: 3673314
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3673314

SequenceSite1890
type: SequenceSite
position status: EQUAL
sequence position: 109

SequenceSite1891
type: SequenceSite
position status: EQUAL
sequence position: 36

http://identifiers.org/pubmed/7851425
type: PublicationXref
id: 7851425
author: Barra, D
author: Simmaco, M
author: John, RA
author: Bossa, F
author: De Biase, D
db: Pubmed
title: Primary structure and tissue distribution of human 4-aminobutyrate aminotransferase
source: Eur J Biochem 227:476-80
year: 1995

SequenceSite1892
type: SequenceSite
position status: EQUAL
sequence position: 509

SequenceSite1893
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite1894
type: SequenceSite
position status: EQUAL
sequence position: 390

SequenceSite1895
type: SequenceSite
position status: EQUAL
sequence position: 31

SequenceSite1896
type: SequenceSite
position status: EQUAL
sequence position: 359

SequenceSite1897
type: SequenceSite
position status: EQUAL
sequence position: 54

UnificationXref1809
type: UnificationXref
id: 3669956
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669956

UnificationXref1807
type: UnificationXref
id: REACT_97284
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97284.9

UnificationXref1808
type: UnificationXref
id: Q04491
db: UniProt

UnificationXref1805
type: UnificationXref
id: 3669913
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669913

UnificationXref1806
type: UnificationXref
id: 3669926
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669926

UnificationXref1803
type: UnificationXref
id: 29420
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29420

UnificationXref1804
type: UnificationXref
id: REACT_4014
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4014.1

Cori ester
type: SmallMoleculeReference
name: alpha-D-Glucose 1-phosphate
name: D-Glucose 1-phosphate [ChEBI:16077]
name: D-Glucose alpha-1-phosphate
name: D-Glucose 1-phosphate
xref: UnificationXref2790

UnificationXref3028
type: UnificationXref
id: P53228
db: UniProt

UnificationXref3027
type: UnificationXref
id: 3666532
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666532

UnificationXref3029
type: UnificationXref
id: 3666536
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666536

UnificationXref3024
type: UnificationXref
id: 29878
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29878

UnificationXref1802
type: UnificationXref
id: CHEBI:17552
db: ChEBI

UnificationXref3023
type: UnificationXref
id: CHEBI:16897
db: ChEBI

UnificationXref1801
type: UnificationXref
id: 3669912
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669912

UnificationXref3026
type: UnificationXref
id: P15019
db: UniProt

UnificationXref1800
type: UnificationXref
id: REACT_71100
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_71100.10

UnificationXref3025
type: UnificationXref
id: REACT_2886
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2886.2

http://identifiers.org/pubmed/20206686
type: PublicationXref
id: 20206686
author: Bradshaw, JM
db: Pubmed
title: The Src, Syk, and Tec family kinases: distinct types of molecular switches
source: Cell Signal 22:1175-84
year: 2010

UnificationXref3020
type: UnificationXref
id: CHEBI:15721
db: ChEBI

http://identifiers.org/pubmed/1429593
type: PublicationXref
id: 1429593
author: Mahnke-Zizelman, DK
author: Bausch-Jurken, MT
author: Sabina, RL
author: Morisaki, T
db: Pubmed
title: Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA
source: J Biol Chem 267:22407-13
year: 1992

UnificationXref3022
type: UnificationXref
id: REACT_5523
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5523.1

UnificationXref3021
type: UnificationXref
id: 29882
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29882

UnificationXref1818
type: UnificationXref
id: GO:0012507
db: GENE ONTOLOGY

UnificationXref3040
type: UnificationXref
id: 3666528
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666528

UnificationXref1819
type: UnificationXref
id: 3669951
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669951

UnificationXref1814
type: UnificationXref
id: 3669935
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669935

UnificationXref1815
type: UnificationXref
id: 3669936
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669936

UnificationXref1816
type: UnificationXref
id: 3669959
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669959

UnificationXref1817
type: UnificationXref
id: REACT_100217
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100217.9

http://identifiers.org/pubmed/17041586
type: PublicationXref
id: 17041586
author: Coadwell, J
author: Welch, H
author: Suire, S
author: Chilvers, ER
author: Guillou, H
author: Davidson, K
author: Condliffe, AM
author: Stephens, L
author: Hawkins, PT
author: Ferguson, GJ
author: Turner, M
author: Ellson, CD
db: Pubmed
title: Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils
source: Nat Cell Biol 8:1303-9
year: 2006

UnificationXref3039
type: UnificationXref
id: 3666526
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3666526

ChEBI:60125 N-epsilon-(1-(1-carboxy)ethyl)lysine
type: SmallMoleculeReference
name: N-epsilon-(1-(1-carboxy)ethyl)lysine
xref: UnificationXref9257

UnificationXref3038
type: UnificationXref
id: Q12189
db: UniProt

UnificationXref3037
type: UnificationXref
id: REACT_4214
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4214.2

UnificationXref1811
type: UnificationXref
id: 3669955
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669955

UnificationXref3036
type: UnificationXref
id: 73578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73578

UnificationXref1810
type: UnificationXref
id: P38968
db: UniProt

UnificationXref3035
type: UnificationXref
id: CHEBI:17797
db: ChEBI

UnificationXref1813
type: UnificationXref
id: 3669934
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3669934

UnificationXref3034
type: UnificationXref
id: REACT_105812
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105812.9