D0QEZ6
type: Protein
entity reference: D0QEZ6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5658
feature: FragmentFeature1126
cellular location: GO:0031088
comment: Reactome DB_ID: 3655760
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEX7
data source: Provenance1
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: D0QEX7
name: MRP4_HUMAN
xref: UnificationXref5659
feature: FragmentFeature1127
cellular location: GO:0031088
comment: Reactome DB_ID: 3655761
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U0N4
data source: Provenance1
name: MOAT-B
name: Q9U0N4
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5660
feature: FragmentFeature1128
cellular location: GO:0031088
comment: Reactome DB_ID: 3655762
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEZ3
data source: Provenance1
name: MOAT-B
name: D0QEZ3
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5661
feature: FragmentFeature1129
cellular location: GO:0031088
comment: Reactome DB_ID: 3655763
display name: ABCC4

UnificationXref2940
type: UnificationXref
id: REACT_2983
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2983.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEV0
data source: Provenance1
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: D0QEV0
name: MRP4_HUMAN
xref: UnificationXref5656
feature: FragmentFeature1124
cellular location: GO:0031088
comment: Reactome DB_ID: 3655758
display name: ABCC4

UnificationXref2941
type: UnificationXref
id: 110680
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110680

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QF40
data source: Provenance1
name: MOAT-B
name: D0QF40
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5657
feature: FragmentFeature1125
cellular location: GO:0031088
comment: Reactome DB_ID: 3655759
display name: ABCC4

UnificationXref2942
type: UnificationXref
id: REACT_4429
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4429.2

UnificationXref524
type: UnificationXref
id: 3656521
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656521

UnificationXref523
type: UnificationXref
id: 3656520
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656520

UnificationXref526
type: UnificationXref
id: 3656523
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656523

UnificationXref525
type: UnificationXref
id: 3656522
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656522

UnificationXref520
type: UnificationXref
id: 3656517
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656517

UnificationXref522
type: UnificationXref
id: 3656519
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656519

UnificationXref521
type: UnificationXref
id: 3656518
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656518

UnificationXref516
type: UnificationXref
id: 3656513
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656513

UniProt:O96236
type: ProteinReference
xref: UnificationXref4586
organism: BioSource1

UnificationXref517
type: UnificationXref
id: 3656514
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656514

UnificationXref518
type: UnificationXref
id: 3656515
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656515

UnificationXref519
type: UnificationXref
id: 3656516
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656516

UnificationXref2933
type: UnificationXref
id: 113525
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113525

D5L5S7
type: Protein
entity reference: UniProt:D5L5S7
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5655
feature: FragmentFeature1123
cellular location: GO:0031088
comment: Reactome DB_ID: 3655757
display name: ABCC4

UnificationXref2932
type: UnificationXref
id: REACT_140293
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140293.5

UnificationXref2935
type: UnificationXref
id: 110638
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110638

UnificationXref2934
type: UnificationXref
id: REACT_3998
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3998.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QF07
data source: Provenance1
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: D0QF07
name: MRP4_HUMAN
xref: UnificationXref5652
feature: FragmentFeature1120
cellular location: GO:0031088
comment: Reactome DB_ID: 3655754
display name: ABCC4

UnificationXref2937
type: UnificationXref
id: 110732
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110732

D0QF15
type: Protein
entity reference: D0QF15
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5651
feature: FragmentFeature1119
cellular location: GO:0031088
comment: Reactome DB_ID: 3655753
display name: ABCC4

UnificationXref2936
type: UnificationXref
id: REACT_5419
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5419.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QF23
data source: Provenance1
name: MOAT-B
name: D0QF23
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5654
feature: FragmentFeature1122
cellular location: GO:0031088
comment: Reactome DB_ID: 3655756
display name: ABCC4

UnificationXref2939
type: UnificationXref
id: 110652
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110652

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QF19
data source: Provenance1
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: D0QF19
name: MRP4_HUMAN
xref: UnificationXref5653
feature: FragmentFeature1121
cellular location: GO:0031088
comment: Reactome DB_ID: 3655755
display name: ABCC4

UnificationXref2938
type: UnificationXref
id: REACT_5595
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5595.2

Q25790
type: Protein
entity reference: Q25790
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: alpha tubulin -1
xref: UnificationXref5678
feature: FragmentFeature1136
cellular location: GO:0005576
comment: Reactome DB_ID: 3656011
display name: TUBA4A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IFP3
data source: Provenance1
name: Q8IFP3
name: alpha tubulin -1
xref: UnificationXref5679
feature: FragmentFeature1137
cellular location: GO:0005576
comment: Reactome DB_ID: 3656012
display name: TUBA4A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8IC11
data source: Provenance1
name: Bromodomain and PHD finger-containing protein 3
name: Q8IC11
xref: UnificationXref5676
feature: FragmentFeature1135
cellular location: GO:0005829
comment: Reactome DB_ID: 3656009
display name: BRPF3

Homologues of TUBA4A
type: Protein
data source: Provenance1
member physical entity: Q25790
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q6ZLZ9
xref: UnificationXref5681
cellular location: GO:0005576
comment: Reactome DB_ID: 3656014
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P14223
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: P14223
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
xref: UnificationXref5670
feature: FragmentFeature1133
cellular location: GO:0005576
comment: Reactome DB_ID: 3655994
display name: ALDOA

UnificationXref2930
type: UnificationXref
id: REACT_126295
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126295.5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KQL9
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: Q7KQL9
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
xref: UnificationXref5671
feature: FragmentFeature1134
cellular location: GO:0005576
comment: Reactome DB_ID: 3655995
display name: ALDOA

UnificationXref2931
type: UnificationXref
id: 3656005
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656005

Homologues of ALDOA
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5672
cellular location: GO:0005576
comment: Reactome DB_ID: 3655996
comment: Converted from EntitySet in Reactome

UnificationXref515
type: UnificationXref
id: 3656478
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656478

http://identifiers.org/pubmed/9809442
type: PublicationXref
id: 9809442
author: Marin-Garcia, J
author: Ananthakrishnan, R
author: Goldenthal, MJ
db: Pubmed
title: Cloning and molecular analysis of the human citrate synthase gene
source: Genome 41:733-738
year: 1998

UnificationXref514
type: UnificationXref
id: 3656477
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656477

UniProt:O96232
type: ProteinReference
xref: UnificationXref1676
organism: BioSource1

UnificationXref513
type: UnificationXref
id: 3656476
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656476

UnificationXref512
type: UnificationXref
id: 3656475
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656475

UniProt:O96230
type: ProteinReference
xref: UnificationXref1666
organism: BioSource1

UnificationXref511
type: UnificationXref
id: 3656474
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656474

UnificationXref510
type: UnificationXref
id: 3656473
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656473

UniProt:Q86RA7
type: ProteinReference
xref: UnificationXref5914
organism: BioSource1

UnificationXref509
type: UnificationXref
id: 3656472
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656472

UnificationXref2929
type: UnificationXref
id: 3656004
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656004

UnificationXref507
type: UnificationXref
id: 3656470
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656470

UnificationXref508
type: UnificationXref
id: 3656471
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656471

UnificationXref505
type: UnificationXref
id: 3656468
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656468

Polymerase switching
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction312
pathway component: BiochemicalReaction313
pathway component: BiochemicalReaction314
evidence: Evidence601
xref: UnificationXref5000
xref: UnificationXref4999
pathway order: PathwayStep583
pathway order: PathwayStep582
pathway order: PathwayStep584
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref506
type: UnificationXref
id: 3656469
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656469

UnificationXref2924
type: UnificationXref
id: 482625
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=482625

UnificationXref2923
type: UnificationXref
id: REACT_4768
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4768.1

UnificationXref2922
type: UnificationXref
id: 110685
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110685

UnificationXref2921
type: UnificationXref
id: REACT_2310
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2310.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KQL9
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: Q7KQL9
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
xref: UnificationXref5668
feature: FragmentFeature1132
cellular location: GO:0031093
comment: Reactome DB_ID: 3655992
display name: ALDOA

UnificationXref2928
type: UnificationXref
id: 3656002
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656002

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P14223
data source: Provenance1
name: Lung cancer antigen NY-LU-1
name: P14223
name: Fructose-bisphosphate aldolase A
name: Muscle-type aldolase
xref: UnificationXref5667
feature: FragmentFeature1131
cellular location: GO:0031093
comment: Reactome DB_ID: 3655991
display name: ALDOA

UnificationXref2927
type: UnificationXref
id: 3656001
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656001

Homologues of ALDOA
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5669
cellular location: GO:0031093
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655993

UnificationXref2926
type: UnificationXref
id: Q8ID43
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:D5L5S3
data source: Provenance1
name: MOAT-B
name: D5L5S3
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5662
feature: FragmentFeature1130
cellular location: GO:0031088
comment: Reactome DB_ID: 3655764
display name: ABCC4

UnificationXref2925
type: UnificationXref
id: REACT_21786
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21786.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P24044
data source: Provenance1
name: CALM_HUMAN
name: Calmodulin
name: P24044
xref: UnificationXref5683
feature: FragmentFeature1140
cellular location: GO:0005576
comment: Reactome DB_ID: 3656016
display name: CALM1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8IC11
data source: Provenance1
name: Bromodomain and PHD finger-containing protein 3
name: Q8IC11
xref: UnificationXref5685
feature: FragmentFeature1141
cellular location: GO:0005576
comment: Reactome DB_ID: 3656018
display name: BRPF3

Homologues of CALU
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5697
cellular location: GO:0005788
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655257

Utilization of Ketone Bodies
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction100
evidence: Evidence209
xref: UnificationXref1795
xref: RelationshipXref178
xref: UnificationXref1796
pathway order: PathwayStep203
display name: Ketone body catabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IIR7
data source: Provenance1
name: Q8IIR7
name: Calumenin
xref: UnificationXref5690
feature: FragmentFeature1142
cellular location: GO:0005788
comment: Reactome DB_ID: 3655250
display name: CALU

UnificationXref2920
type: UnificationXref
id: 110711
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110711

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U460
data source: Provenance1
name: Q9U460
name: Calumenin
xref: UnificationXref5692
feature: FragmentFeature1143
cellular location: GO:0005788
comment: Reactome DB_ID: 3655252
display name: CALU

http://identifiers.org/pubmed/16322778
type: PublicationXref
id: 16322778
author: Kaushansky, K
db: Pubmed
title: The molecular mechanisms that control thrombopoiesis
source: J Clin Invest 115:3339-47
year: 2005

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q25793
data source: Provenance1
name: Q25793
name: Calumenin
xref: UnificationXref5694
feature: FragmentFeature1144
cellular location: GO:0005788
comment: Reactome DB_ID: 3655254
display name: CALU

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9TY81
data source: Provenance1
name: Q9TY81
name: Calumenin
xref: UnificationXref5696
feature: FragmentFeature1145
cellular location: GO:0005788
comment: Reactome DB_ID: 3655256
display name: CALU

UniProt:O96260
type: ProteinReference
xref: UnificationXref4965
organism: BioSource1

Homologues of CALU
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5702
cellular location: GO:0005576
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655262

UnificationXref500
type: UnificationXref
id: 3656463
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656463

UniProt:O97313
type: ProteinReference
xref: UnificationXref1062
organism: BioSource1

UniProt:O96265
type: ProteinReference
xref: UnificationXref4632
organism: BioSource1

UnificationXref502
type: UnificationXref
id: 3656465
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656465

UniProt:O96266
type: ProteinReference
xref: UnificationXref1901
organism: BioSource1

UnificationXref501
type: UnificationXref
id: 3656464
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656464

UnificationXref504
type: UnificationXref
id: 3656467
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656467

UnificationXref503
type: UnificationXref
id: 3656466
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656466

UniProt:O96258
type: ProteinReference
xref: UnificationXref1035
organism: BioSource1

UnificationXref2919
type: UnificationXref
id: CHEBI:18077
db: ChEBI

UnificationXref2918
type: UnificationXref
id: REACT_2857
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2857.1

Homologues of CALM1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5684
cellular location: GO:0005576
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656017

UnificationXref2915
type: UnificationXref
id: REACT_2490
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2490.1

Q6ZLZ9
type: Protein
entity reference: Q6ZLZ9
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: alpha tubulin -1
xref: UnificationXref5680
feature: FragmentFeature1138
cellular location: GO:0005576
comment: Reactome DB_ID: 3656013
display name: TUBA4A

UnificationXref2914
type: UnificationXref
id: 110672
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110672

UnificationXref2917
type: UnificationXref
id: 110660
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110660

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P62203
data source: Provenance1
name: CALM_HUMAN
name: Calmodulin
name: P62203
xref: UnificationXref5682
feature: FragmentFeature1139
cellular location: GO:0005576
comment: Reactome DB_ID: 3656015
display name: CALM1

UnificationXref2916
type: UnificationXref
id: CHEBI:16311
db: ChEBI

UnificationXref2911
type: UnificationXref
id: 482627
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=482627

UnificationXref2910
type: UnificationXref
id: REACT_100755
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100755.9

UnificationXref2913
type: UnificationXref
id: CHEBI:16497
db: ChEBI

UnificationXref2912
type: UnificationXref
id: REACT_21492
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21492.1

http://identifiers.org/pubmed/642006
type: PublicationXref
id: 642006
author: Gall, JG
author: Blackburn, EH
db: Pubmed
title: A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena
source: J Mol Biol 120:33-53
year: 1978

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I3I2
data source: Provenance1
name: F-actin-capping protein subunit alpha-1
name: Q8I3I2
name: CAZA1_HUMAN
xref: UnificationXref5715
feature: FragmentFeature1151
cellular location: GO:0005829
comment: Reactome DB_ID: 3656153
display name: CAPZA1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I3T2
data source: Provenance1
name: Q8I3T2
name: CAPZB_HUMAN
name: F-actin-capping protein subunit beta
xref: UnificationXref5717
feature: FragmentFeature1152
cellular location: GO:0005829
comment: Reactome DB_ID: 3656157
display name: CAPZB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9TY81
data source: Provenance1
name: Q9TY81
name: Calumenin
xref: UnificationXref5701
feature: FragmentFeature1149
cellular location: GO:0005576
comment: Reactome DB_ID: 3655261
display name: CALU

http://identifiers.org/pubmed/17986282
type: PublicationXref
id: 17986282
author: Uemura, M
author: Nakagawa, H
author: Nakamura, Y
author: Chung, S
author: Tamura, K
author: Honma, S
author: Okuyama, A
db: Pubmed
title: Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer
source: Cancer Sci 99:81-6
year: 2008

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P12794
data source: Provenance1
name: 78 kDa glucose-regulated protein
name: P12794
xref: UnificationXref5705
feature: FragmentFeature1150
cellular location: GO:0005576
comment: Reactome DB_ID: 3655277
display name: HSPA5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I444
data source: Provenance1
name: proSUMO1
name: SUMO1(2-101)
name: SUMO1_HUMAN
name: Small ubiquitin-related modifier 1
name: Q8I444
xref: UnificationXref5738
feature: FragmentFeature1155
cellular location: GO:0005654
comment: Reactome DB_ID: 3657070
display name: SUMO1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I444
data source: Provenance1
name: SUMO1_HUMAN
name: Small ubiquitin-related modifier 1
name: Q8I444
xref: UnificationXref5739
feature: FragmentFeature1156
cellular location: GO:0005654
comment: Reactome DB_ID: 3657064
display name: SUMO1

Q8I4X5
type: Protein
entity reference: Q8I4X5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: KIF22
name: KIF22_HUMAN
name: Kinesin-like protein KIF22
xref: UnificationXref5722
feature: FragmentFeature1153
cellular location: GO:0005829
comment: Reactome DB_ID: 3656294
display name: KID

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8I5U0
data source: Provenance1
name: Q8I5U0
name: CENP-E
xref: UnificationXref5727
feature: FragmentFeature1154
cellular location: GO:0005829
comment: Reactome DB_ID: 3656300
display name: CENPE

http://identifiers.org/pubmed/10075700
type: PublicationXref
id: 10075700
author: Cooper, DM
author: Gu, C
db: Pubmed
title: Calmodulin-binding sites on adenylyl cyclase type VIII
source: J Biol Chem 274:8012-21
year: 1999

http://identifiers.org/pubmed/18786386
type: PublicationXref
id: 18786386
author: Maywood, ES
author: O'Neill, JS
author: Hastings, MH
db: Pubmed
title: Cellular circadian pacemaking and the role of cytosolic rhythms
source: Curr Biol 18:R805-R815
year: 2008

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q25793
data source: Provenance1
name: Q25793
name: Calumenin
xref: UnificationXref5700
feature: FragmentFeature1148
cellular location: GO:0005576
comment: Reactome DB_ID: 3655260
display name: CALU

UnificationXref2909
type: UnificationXref
id: 3653053
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653053

UnificationXref2908
type: UnificationXref
id: 3653051
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653051

UnificationXref2907
type: UnificationXref
id: 3653050
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653050

6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol [ChEBI:64181]
type: SmallMoleculeReference
name: 6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol
xref: UnificationXref2340

UnificationXref2906
type: UnificationXref
id: O15770
db: UniProt

2-methoxy-6-decaprenyl-1,4-benzoquinol [ChEBI:64180]
type: SmallMoleculeReference
name: 2-methoxy-6-decaprenyl-1,4-benzoquinol
xref: UnificationXref2337

UnificationXref2905
type: UnificationXref
id: REACT_4227
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4227.1

ubiquinol-10 [ChEBI:64183]
type: SmallMoleculeReference
name: ubiquinol-10
xref: UnificationXref2350

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U460
data source: Provenance1
name: Q9U460
name: Calumenin
xref: UnificationXref5699
feature: FragmentFeature1147
cellular location: GO:0005576
comment: Reactome DB_ID: 3655259
display name: CALU

UnificationXref2904
type: UnificationXref
id: 29386
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29386

3-demethylubiquinol-10
type: SmallMoleculeReference
name: 3-demethylubiquinol-10 [ChEBI:64182]
xref: UnificationXref2347

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IIR7
data source: Provenance1
name: Q8IIR7
name: Calumenin
xref: UnificationXref5698
feature: FragmentFeature1146
cellular location: GO:0005576
comment: Reactome DB_ID: 3655258
display name: CALU

UnificationXref2903
type: UnificationXref
id: REACT_93431
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93431.9

http://identifiers.org/pubmed/11158296
type: PublicationXref
id: 11158296
author: Pelzer, W
author: Kmita, H
author: Diekert, K
author: Bedekovics, T
author: Lill, R
author: Prohl, C
author: Kispal, G
db: Pubmed
title: The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix
source: Mol Cell Biol 21:1089-97
year: 2001

UnificationXref2902
type: UnificationXref
id: 3654317
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654317

UnificationXref2901
type: UnificationXref
id: REACT_5673
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5673.1

UnificationXref2900
type: UnificationXref
id: 110644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110644

Phosphodiesterase 3A
type: Protein
entity reference: B3FEM7
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
name: B3FEM7
name: PDE3A_HUMAN
xref: UnificationXref5596
feature: FragmentFeature1089
cellular location: GO:0005829
comment: Reactome DB_ID: 3655641
display name: PDE3A

Phosphodiesterase 3A
type: Protein
entity reference: UniProt:Q8I6Z7
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8I6Z7
name: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
name: PDE3A_HUMAN
xref: UnificationXref5595
feature: FragmentFeature1088
cellular location: GO:0005829
comment: Reactome DB_ID: 3655640
display name: PDE3A

http://identifiers.org/pubmed/23222971
type: PublicationXref
id: 23222971
author: Lu, Ning
author: Yuan, Bin
author: Zhang, Zhiqiang
author: Bao, Musheng
author: Liu, Yong-Jun
author: Weng, Leiyun
db: Pubmed
title: The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA
source: Nat. Immunol.
year: 2012

Homologues of PDE2A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5593
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655638

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q2V2M6
data source: Provenance1
name: Phosphodiesterase 2A
name: Q2V2M6
name: PDE2A_HUMAN
name: cGMP-dependent 3',5'-cyclic phosphodiesterase
xref: UnificationXref5591
feature: FragmentFeature1085
cellular location: GO:0005829
comment: Reactome DB_ID: 3655636
display name: PDE2A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8I5V4
data source: Provenance1
name: Phosphodiesterase 2A
name: PDE2A_HUMAN
name: cGMP-dependent 3',5'-cyclic phosphodiesterase
name: Q8I5V4
xref: UnificationXref5592
feature: FragmentFeature1086
cellular location: GO:0005829
comment: Reactome DB_ID: 3655637
display name: PDE2A

Homologues of PDE3A
type: Protein
data source: Provenance1
member physical entity: Phosphodiesterase 3A
xref: UnificationXref5597
cellular location: GO:0005829
comment: Reactome DB_ID: 3655642
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8I5V4
data source: Provenance1
name: Phosphodiesterase 5A
name: PDE5A_HUMAN
name: Q8I5V4
name: cGMP-specific 3',5'-cyclic phosphodiesterase 5A
xref: UnificationXref5585
feature: FragmentFeature1082
cellular location: GO:0005829
comment: Reactome DB_ID: 3655630
display name: PDE5A

carbovir diphosphate [ChEBI:64172]
type: SmallMoleculeReference
name: carbovir diphosphate
xref: UnificationXref3618

Homologues of PDE9A
type: Protein
data source: Provenance1
member physical entity: PDE9A_HUMAN
xref: UnificationXref5589
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655634

PDE9A_HUMAN
type: Protein
entity reference: UniProt:Q2V2M6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q2V2M6
name: Phosphodiesterase 9A
name: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
xref: UnificationXref5587
feature: FragmentFeature1083
cellular location: GO:0005829
comment: Reactome DB_ID: 3655632
display name: PDE9A

http://identifiers.org/pubmed/17697045
type: PublicationXref
id: 17697045
author: Mikoshiba, K
db: Pubmed
title: IP3 receptor/Ca2+ channel: from discovery to new signaling concepts
source: J Neurochem 102:1426-46
year: 2007

PDE9A_HUMAN
type: Protein
entity reference: UniProt:Q8I5V4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Phosphodiesterase 9A
name: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
name: Q8I5V4
xref: UnificationXref5588
feature: FragmentFeature1084
cellular location: GO:0005829
comment: Reactome DB_ID: 3655633
display name: PDE9A

Phosphodiesterase 3A
type: Protein
entity reference: Q8IKD3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
name: Q8IKD3
name: PDE3A_HUMAN
xref: UnificationXref5594
feature: FragmentFeature1087
cellular location: GO:0005829
comment: Reactome DB_ID: 3655639
display name: PDE3A

UniProt:Q9GQW6
type: ProteinReference
xref: UnificationXref4983
organism: BioSource1

Catalysis100
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction111
control type: ACTIVATION
xref: RelationshipXref201
xref: RelationshipXref200
controller: Protein538

Sphingolipid metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 118447.7
evidence: Evidence283
xref: UnificationXref2290
xref: UnificationXref2289
xref: RelationshipXref261
pathway order: PathwayStep277
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Catalysis101
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction112
control type: ACTIVATION
xref: RelationshipXref204
xref: RelationshipXref203
controller: PCYT2 dimer (name copied from entity in Homo sapiens)

Catalysis104
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction115
control type: ACTIVATION
xref: RelationshipXref208
xref: RelationshipXref209
controller: Complex103

Catalysis105
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction116
control type: ACTIVATION
xref: RelationshipXref212
xref: RelationshipXref211
controller: Protein551

Catalysis102
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction113
control type: ACTIVATION
xref: RelationshipXref205
xref: RelationshipXref168
controller: LPIN

Catalysis103
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction114
control type: ACTIVATION
xref: RelationshipXref206
xref: RelationshipXref207
controller: Complex100

UniProt:O96271
type: ProteinReference
xref: UnificationXref4985
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O96197
data source: Provenance1
name: C-Raf
name: O96197
xref: UnificationXref5618
feature: FragmentFeature1097
cellular location: GO:0005829
comment: Reactome DB_ID: 3655834
display name: RAF1

Catalysis108
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction119
control type: ACTIVATION
xref: RelationshipXref218
xref: RelationshipXref216
controller: Complex107

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8I5V4
data source: Provenance1
name: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
name: Phosphodiesterase 11A
name: PDE11A(1-934)
name: PDE11_HUMAN
name: Q8I5V4
xref: UnificationXref5606
feature: FragmentFeature1096
cellular location: GO:0005829
comment: Reactome DB_ID: 3655647
display name: PDE11A

Catalysis109
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction120
control type: ACTIVATION
xref: RelationshipXref212
xref: RelationshipXref211
controller: Protein551

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q2V2M6
data source: Provenance1
name: Q2V2M6
name: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
name: Phosphodiesterase 11A
name: PDE11A(1-934)
name: PDE11_HUMAN
xref: UnificationXref5605
feature: FragmentFeature1095
cellular location: GO:0005829
comment: Reactome DB_ID: 3655646
display name: PDE11A

Catalysis106
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction117
control type: ACTIVATION
xref: RelationshipXref214
xref: RelationshipXref215
controller: Complex104

Catalysis107
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction118
control type: ACTIVATION
xref: RelationshipXref217
xref: RelationshipXref216
controller: Complex101

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8I5V4
data source: Provenance1
name: PDE10_HUMAN
name: Phosphodiesterase 10A
name: Q8I5V4
name: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
xref: UnificationXref5603
feature: FragmentFeature1094
cellular location: GO:0005829
comment: Reactome DB_ID: 3655644
display name: PDE10A

Homologues of PDE11A(1-934)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5607
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655648

Homologues of PDE10A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5604
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655645

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q2V2M6
data source: Provenance1
name: PDE10_HUMAN
name: Q2V2M6
name: Phosphodiesterase 10A
name: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
xref: UnificationXref5602
feature: FragmentFeature1093
cellular location: GO:0005829
comment: Reactome DB_ID: 3655643
display name: PDE10A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8I6Z7
data source: Provenance1
name: Phosphodiesterase 3B
name: Q8I6Z7
xref: UnificationXref5599
feature: FragmentFeature1091
cellular location: GO:0005829
comment: Reactome DB_ID: 3654520
display name: PDE3B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B3FEM7
data source: Provenance1
name: Phosphodiesterase 3B
name: B3FEM7
xref: UnificationXref5600
feature: FragmentFeature1092
cellular location: GO:0005829
comment: Reactome DB_ID: 3654524
display name: PDE3B

Homologues of PDE3B
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5601
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654525

http://identifiers.org/pubmed/9188485
type: PublicationXref
id: 9188485
author: Folk, JE
author: Park, MH
author: Wolff, EC
db: Pubmed
title: Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase
source: J Biol Chem 272:15865-71
year: 1997

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IKD3
data source: Provenance1
name: Phosphodiesterase 3B
name: Q8IKD3
xref: UnificationXref5598
feature: FragmentFeature1090
cellular location: GO:0005829
comment: Reactome DB_ID: 3654516
display name: PDE3B

UniProt:O96269
type: ProteinReference
xref: UnificationXref1052
organism: BioSource1

7,8-dihydro-7-hydroxy-8S-glutathionylbenzo[a]pyrene
type: SmallMoleculeReference
name: 7,8-dihydro-7-hydroxy-8S-glutathionylbenzo[a]pyrene [ChEBI:34479]
name: 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
xref: UnificationXref3560

http://identifiers.org/pubmed/12883891
type: PublicationXref
id: 12883891
author: Koepsell, H
author: Endou, H
db: Pubmed
title: The SLC22 drug transporter family
source: Pflugers Arch 447:666-76
year: 2004

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEY2
data source: Provenance1
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: D0QEY2
name: MRP4_HUMAN
xref: UnificationXref5637
feature: FragmentFeature1105
cellular location: GO:0031088
comment: Reactome DB_ID: 3655739
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEW0
data source: Provenance1
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: D0QEW0
name: MRP4_HUMAN
xref: UnificationXref5636
feature: FragmentFeature1104
cellular location: GO:0031088
comment: Reactome DB_ID: 3655738
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QF04
data source: Provenance1
name: D0QF04
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5639
feature: FragmentFeature1107
cellular location: GO:0031088
comment: Reactome DB_ID: 3655741
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QF32
data source: Provenance1
name: MOAT-B
name: D0QF32
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5638
feature: FragmentFeature1106
cellular location: GO:0031088
comment: Reactome DB_ID: 3655740
display name: ABCC4

Homologues of ABCC4
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: D5L5S7
member physical entity: D0QEZ6
member physical entity: D5L5S8
member physical entity: D0QF15
xref: UnificationXref5663
cellular location: GO:0031088
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655765

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I5C7
data source: Provenance1
name: Q8I5C7
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5630
feature: FragmentFeature1098
cellular location: GO:0031088
comment: Reactome DB_ID: 3655732
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEU4
data source: Provenance1
name: D0QEU4
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5631
feature: FragmentFeature1099
cellular location: GO:0031088
comment: Reactome DB_ID: 3655733
display name: ABCC4

http://identifiers.org/pubmed/10753883
type: PublicationXref
id: 10753883
author: Fukami, K
author: Funaki, M
author: Asano, T
author: Mochizuki, Y
author: Ijuin, T
author: Takenawa, T
db: Pubmed
title: Identification and characterization of a novel inositol polyphosphate 5-phosphatase
source: J Biol Chem 275:10870-5
year: 2000

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEU6
data source: Provenance1
name: MOAT-B
name: D0QEU6
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5632
feature: FragmentFeature1100
cellular location: GO:0031088
comment: Reactome DB_ID: 3655734
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QF37
data source: Provenance1
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: D0QF37
name: MRP4_HUMAN
xref: UnificationXref5633
feature: FragmentFeature1101
cellular location: GO:0031088
comment: Reactome DB_ID: 3655735
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEV8
data source: Provenance1
name: MOAT-B
name: D0QEV8
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5634
feature: FragmentFeature1102
cellular location: GO:0031088
comment: Reactome DB_ID: 3655736
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEU0
data source: Provenance1
name: MOAT-B
name: D0QEU0
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5635
feature: FragmentFeature1103
cellular location: GO:0031088
comment: Reactome DB_ID: 3655737
display name: ABCC4

http://identifiers.org/pubmed/8541526
type: PublicationXref
id: 8541526
author: Park, JG
author: Hunter, S
author: Schreiber, AD
author: Indik, ZK
db: Pubmed
title: The molecular dissection of Fc gamma receptor mediated phagocytosis
source: Blood 86:4389-99
year: 1995

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEU3
data source: Provenance1
name: MOAT-B
name: D0QEU3
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5646
feature: FragmentFeature1114
cellular location: GO:0031088
comment: Reactome DB_ID: 3655748
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: A7XLD3
data source: Provenance1
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: A7XLD3
name: MRP4_HUMAN
xref: UnificationXref5650
feature: FragmentFeature1118
cellular location: GO:0031088
comment: Reactome DB_ID: 3655752
display name: ABCC4

D5L5S8
type: Protein
entity reference: UniProt:D5L5S8
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5649
feature: FragmentFeature1117
cellular location: GO:0031088
comment: Reactome DB_ID: 3655751
display name: ABCC4

Quinidine
type: SmallMoleculeReference
name: Quinidine [ChEBI:8719]
xref: UnificationXref718

http://identifiers.org/pubmed/11395502
type: PublicationXref
id: 11395502
author: Dutta, A
author: Delmolino, L
author: Dhar, SK
db: Pubmed
title: Architecture of the human origin recognition complex.
source: J Biol Chem 276:29067-71
year: 2001

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: A7XLD6
data source: Provenance1
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: A7XLD6
name: MRP4_HUMAN
xref: UnificationXref5648
feature: FragmentFeature1116
cellular location: GO:0031088
comment: Reactome DB_ID: 3655750
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEX1
data source: Provenance1
name: MOAT-B
name: D0QEX1
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5647
feature: FragmentFeature1115
cellular location: GO:0031088
comment: Reactome DB_ID: 3655749
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEV4
data source: Provenance1
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: D0QEV4
name: MRP4_HUMAN
xref: UnificationXref5642
feature: FragmentFeature1110
cellular location: GO:0031088
comment: Reactome DB_ID: 3655744
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QF22
data source: Provenance1
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: D0QF22
name: MRP4_HUMAN
xref: UnificationXref5643
feature: FragmentFeature1111
cellular location: GO:0031088
comment: Reactome DB_ID: 3655745
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QF08
data source: Provenance1
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: D0QF08
name: MRP4_HUMAN
xref: UnificationXref5640
feature: FragmentFeature1108
cellular location: GO:0031088
comment: Reactome DB_ID: 3655742
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEY8
data source: Provenance1
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: D0QEY8
name: MRP4_HUMAN
xref: UnificationXref5641
feature: FragmentFeature1109
cellular location: GO:0031088
comment: Reactome DB_ID: 3655743
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEX4
data source: Provenance1
name: MOAT-B
name: Multidrug resistance-associated protein 4
name: D0QEX4
name: MRP4_HUMAN
xref: UnificationXref5644
feature: FragmentFeature1112
cellular location: GO:0031088
comment: Reactome DB_ID: 3655746
display name: ABCC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D0QEU8
data source: Provenance1
name: MOAT-B
name: D0QEU8
name: Multidrug resistance-associated protein 4
name: MRP4_HUMAN
xref: UnificationXref5645
feature: FragmentFeature1113
cellular location: GO:0031088
comment: Reactome DB_ID: 3655747
display name: ABCC4

Catalysis130
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction141
control type: ACTIVATION
xref: RelationshipXref257
xref: RelationshipXref256
controller: Complex110

Nonsense Mediated Decay Independent of the Exon Junction Complex
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction43
evidence: Evidence123
xref: UnificationXref1236
xref: UnificationXref1235
pathway order: PathwayStep119
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Catalysis139
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction150
control type: ACTIVATION
xref: RelationshipXref279
xref: RelationshipXref280
controller: Complex117

Catalysis134
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction145
control type: ACTIVATION
xref: RelationshipXref266
xref: RelationshipXref267
controller: Protein588

http://identifiers.org/pubmed/11226282
type: PublicationXref
id: 11226282
author: Watanabe, D
author: Matsushita, M
author: Hashimoto, S
author: Baba, Y
author: Kurosaki, T
author: Kishimoto, T
author: Tsukada, S
db: Pubmed
title: BLNK mediates Syk-dependent Btk activation
source: Proc Natl Acad Sci U S A 98:2582-6
year: 2001

Catalysis133
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction144
control type: ACTIVATION
xref: RelationshipXref265
xref: RelationshipXref264
controller: Protein587

http://identifiers.org/pubmed/19443651
type: PublicationXref
id: 19443651
author: Wang, Jianghai
author: Fukui, Lisa
author: Lee, Brian
author: Cai, Sheng
author: Chen, Yuan
author: Hu, Weidong
db: Pubmed
title: Conformational transition associated with E1-E2 interaction in small ubiquitin-like modifications
source: J. Biol. Chem. 284:20340-8
year: 2009

Catalysis132
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction143
control type: ACTIVATION
xref: RelationshipXref262
xref: RelationshipXref263
controller: Complex113

Catalysis131
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction142
control type: ACTIVATION
xref: RelationshipXref259
xref: RelationshipXref258
controller: Protein582

Catalysis138
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction149
control type: ACTIVATION
xref: RelationshipXref275
xref: RelationshipXref274
controller: Complex116

Catalysis137
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction148
control type: ACTIVATION
xref: RelationshipXref273
xref: RelationshipXref44
controller: Complex115

Catalysis136
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction147
control type: ACTIVATION
xref: RelationshipXref271
xref: RelationshipXref270
controller: Protein588

Catalysis135
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction146
control type: ACTIVATION
xref: RelationshipXref269
xref: RelationshipXref268
controller: Protein589

Catalysis140
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction151
control type: ACTIVATION
xref: RelationshipXref284
xref: RelationshipXref283
controller: Complex119

Catalysis141
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction152
control type: ACTIVATION
xref: RelationshipXref286
xref: RelationshipXref287
controller: Complex120

UnificationXref593
type: UnificationXref
id: 189246
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189246

http://identifiers.org/pubmed/6105839
type: PublicationXref
id: 6105839
author: Jones, ME
db: Pubmed
title: Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis.
source: Annu Rev Biochem 49:253-79
year: 1980

UnificationXref592
type: UnificationXref
id: REACT_2878
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2878.2

http://identifiers.org/pubmed/16738315
type: PublicationXref
id: 16738315
author: Lee, Hsiang-Ying
author: Gill, Grace
author: Catic, Andre
author: Di Bacco, A
author: Ouyang, Jian
author: Ploegh, Hidde
db: Pubmed
title: The SUMO-specific protease SENP5 is required for cell division
source: Mol. Cell. Biol. 26:4489-98
year: 2006

UnificationXref595
type: UnificationXref
id: 188995
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=188995

UnificationXref594
type: UnificationXref
id: REACT_9838
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9838.3

http://identifiers.org/pubmed/16169847
type: PublicationXref
id: 16169847
author: Treadwell, L
author: Warrington, JA
author: Wolfe, CL
author: Norcum, MT
db: Pubmed
title: A three-dimensional working model of the multienzyme complex of aminoacyl-tRNA synthetases based on electron microscopic placements of tRNA and proteins
source: J Biol Chem 280:38870-8
year: 2005

UnificationXref591
type: UnificationXref
id: 70113
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70113

UnificationXref590
type: UnificationXref
id: CHEBI:17925
db: ChEBI

Catalysis143
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction154
control type: ACTIVATION
xref: RelationshipXref290
xref: RelationshipXref291
controller: Complex122

Catalysis142
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction153
control type: ACTIVATION
xref: RelationshipXref289
xref: RelationshipXref288
controller: Complex121

Catalysis145
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction156
control type: ACTIVATION
xref: RelationshipXref295
xref: RelationshipXref296
controller: Protein612

Catalysis144
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction155
control type: ACTIVATION
xref: RelationshipXref292
xref: RelationshipXref293
controller: Complex128

UnificationXref597
type: UnificationXref
id: 70115
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70115

Catalysis147
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction158
control type: ACTIVATION
xref: RelationshipXref301
xref: RelationshipXref300
controller: Protein616

UnificationXref596
type: UnificationXref
id: REACT_9840
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9840.2

Catalysis146
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction157
control type: ACTIVATION
xref: RelationshipXref299
xref: RelationshipXref298
controller: Complex129

UnificationXref599
type: UnificationXref
id: 189219
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189219

Catalysis149
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction160
control type: ACTIVATION
xref: RelationshipXref305
xref: RelationshipXref306
controller: Protein625

UnificationXref598
type: UnificationXref
id: REACT_4078
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4078.3

Catalysis148
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction159
control type: ACTIVATION
xref: RelationshipXref303
xref: RelationshipXref302
controller: Complex130

http://identifiers.org/pubmed/15153069
type: PublicationXref
id: 15153069
author: Lake, S
author: Climent, I
author: Swiezewska, E
author: Forsgren, M
author: Attersand, A
author: Dallner, G
author: Grünler, J
db: Pubmed
title: Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ
source: Biochem J 382:519-26
year: 2004

UnificationXref580
type: UnificationXref
id: 29532
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29532

UnificationXref584
type: UnificationXref
id: 3654747
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654747

UnificationXref583
type: UnificationXref
id: 3654746
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654746

Catalysis119
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction130
control type: ACTIVATION
xref: RelationshipXref157
xref: RelationshipXref241
controller: Protein568

http://identifiers.org/pubmed/11681785
type: PublicationXref
id: 11681785
author: Hruz, PW
author: Mueckler, MM
db: Pubmed
title: Structural analysis of the GLUT1 facilitative glucose transporter (review).
source: Mol Membr Biol 18:183-93
year: 2001

UnificationXref582
type: UnificationXref
id: 3654745
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654745

Catalysis118
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction129
control type: ACTIVATION
xref: RelationshipXref161
xref: RelationshipXref157
controller: Protein518

UnificationXref581
type: UnificationXref
id: REACT_5180
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5180.3

Catalysis117
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction128
control type: ACTIVATION
xref: RelationshipXref238
xref: RelationshipXref239
controller: Protein566

UnificationXref588
type: UnificationXref
id: 29590
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29590

Catalysis116
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction127
control type: ACTIVATION
xref: RelationshipXref236
xref: RelationshipXref237
controller: Protein566

UnificationXref587
type: UnificationXref
id: CHEBI:17118
db: ChEBI

Catalysis115
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction126
control type: ACTIVATION
xref: RelationshipXref234
xref: RelationshipXref235
controller: Protein566

UnificationXref586
type: UnificationXref
id: REACT_153908
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153908.3

Catalysis114
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction125
control type: ACTIVATION
xref: RelationshipXref233
xref: RelationshipXref232
controller: Protein566

UnificationXref585
type: UnificationXref
id: 3654749
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654749

Catalysis113
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction124
control type: ACTIVATION
xref: RelationshipXref230
xref: RelationshipXref231
controller: Protein566

Catalysis112
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction123
control type: ACTIVATION
xref: RelationshipXref227
xref: RelationshipXref211
controller: Protein565

Catalysis111
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction122
control type: ACTIVATION
xref: RelationshipXref225
xref: RelationshipXref224
controller: Protein562

Catalysis110
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction121
control type: ACTIVATION
xref: RelationshipXref221
xref: RelationshipXref222
controller: Complex108

UnificationXref589
type: UnificationXref
id: REACT_3779
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3779.3

http://identifiers.org/pubmed/17336609
type: PublicationXref
id: 17336609
author: Kambayashi, Taku
author: Koretzky, Gary A
db: Pubmed
title: Proximal signaling events in Fc epsilon RI-mediated mast cell activation
source: J. Allergy Clin. Immunol. 119:544-52; quiz 553-4
year: 2007

http://identifiers.org/pubmed/17266529
type: PublicationXref
id: 17266529
author: Hyde, JE
db: Pubmed
title: Targeting purine and pyrimidine metabolism in human apicomplexan parasites
source: Curr Drug Targets 8:31-47
year: 2007

UnificationXref571
type: UnificationXref
id: 3655687
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655687

Catalysis129
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction140
control type: ACTIVATION
xref: RelationshipXref254
xref: RelationshipXref255
controller: Protein578

UnificationXref570
type: UnificationXref
id: 3655685
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655685

Catalysis128
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction139
control type: ACTIVATION
xref: RelationshipXref250
xref: RelationshipXref251
controller: PhysicalEntity45

UnificationXref573
type: UnificationXref
id: 3657437
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657437

UnificationXref572
type: UnificationXref
id: REACT_85878
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85878.9

UnificationXref575
type: UnificationXref
id: 3657438
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657438

Catalysis125
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction136
control type: ACTIVATION
xref: RelationshipXref248
xref: RelationshipXref247
controller: Complex109

UnificationXref574
type: UnificationXref
id: REACT_90775
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90775.9

Catalysis124
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction135
control type: ACTIVATION
xref: RelationshipXref245
xref: RelationshipXref246
controller: Protein569

UnificationXref577
type: UnificationXref
id: CHEBI:15824
db: ChEBI

Catalysis127
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction138
control type: ACTIVATION
xref: RelationshipXref250
xref: RelationshipXref251
controller: PhysicalEntity45

UnificationXref576
type: UnificationXref
id: REACT_96078
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96078.9

Catalysis126
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction137
control type: ACTIVATION
xref: RelationshipXref250
xref: RelationshipXref251
controller: PhysicalEntity45

UnificationXref579
type: UnificationXref
id: REACT_9760
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9760.2

Catalysis121
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction132
control type: ACTIVATION
xref: RelationshipXref161
xref: RelationshipXref157
controller: Protein518

UnificationXref578
type: UnificationXref
id: 189049
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189049

Catalysis120
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction131
control type: ACTIVATION
xref: RelationshipXref159
xref: RelationshipXref157
controller: Protein516

Catalysis123
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction134
control type: ACTIVATION
xref: RelationshipXref159
xref: RelationshipXref157
controller: Protein516

Catalysis122
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction133
control type: ACTIVATION
xref: RelationshipXref157
xref: RelationshipXref241
controller: Protein568

http://identifiers.org/pubmed/12700044
type: PublicationXref
id: 12700044
author: Maness, PF
author: Thelen, K
author: Panicker, AK
author: Buhusi, M
db: Pubmed
title: Cellular signalling mechanisms of neural cell adhesion molecules
source: Front Biosci 8:d900-11
year: 2003

SENP1/2/5
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5743
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3657076

UniProt:Q9GR05
type: ProteinReference
xref: UnificationXref4935
organism: BioSource1

Catalysis170
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction181
control type: ACTIVATION
xref: RelationshipXref344
xref: RelationshipXref343
controller: Complex151

Catalysis174
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction185
control type: ACTIVATION
xref: RelationshipXref347
xref: RelationshipXref345
controller: Complex153

Catalysis173
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction184
control type: ACTIVATION
xref: RelationshipXref347
xref: RelationshipXref345
controller: Complex153

Catalysis172
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction183
control type: ACTIVATION
xref: RelationshipXref345
xref: RelationshipXref346
controller: Complex152

Catalysis171
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction182
control type: ACTIVATION
xref: RelationshipXref345
xref: RelationshipXref346
controller: Complex152

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I583
data source: Provenance1
name: Q8I583
name: SENP2_HUMAN
name: Sentrin-specific protease 2 ecNumber3.4.22.68/ecNumber
xref: UnificationXref5742
feature: FragmentFeature1158
cellular location: GO:0005654
comment: Reactome DB_ID: 3657075
display name: SENP2

UnificationXref569
type: UnificationXref
id: 3655684
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655684

Catalysis177
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction188
control type: ACTIVATION
xref: RelationshipXref353
xref: RelationshipXref354
controller: Complex154

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I583
data source: Provenance1
name: Q8I583
name: Sentrin-specific protease 1 ecNumber3.4.22.68/ecNumber
name: SENP1_HUMAN
xref: UnificationXref5741
feature: FragmentFeature1157
cellular location: GO:0005654
comment: Reactome DB_ID: 3657074
display name: SENP1

Catalysis178
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction189
control type: ACTIVATION
xref: RelationshipXref356
xref: RelationshipXref357
controller: PhysicalEntity47

UniProt:O96200
type: ProteinReference
xref: UnificationXref755
organism: BioSource1

UnificationXref567
type: UnificationXref
id: 3655682
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655682

Catalysis175
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction186
control type: ACTIVATION
xref: RelationshipXref350
xref: RelationshipXref349
controller: Complex154

UnificationXref568
type: UnificationXref
id: 3655683
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655683

Catalysis176
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction187
control type: ACTIVATION
xref: RelationshipXref351
xref: RelationshipXref352
controller: Complex154

UnificationXref565
type: UnificationXref
id: 3655680
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655680

UniProt:Q9GR09
type: ProteinReference
xref: UnificationXref4975
organism: BioSource1

UnificationXref566
type: UnificationXref
id: 3655681
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655681

UniProt:O97330
type: ProteinReference
xref: UnificationXref1656
organism: BioSource1

UniProt:Q9GR06
type: ProteinReference
xref: UnificationXref4928
organism: BioSource1

UnificationXref563
type: UnificationXref
id: 3655678
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655678

Catalysis179
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction190
control type: ACTIVATION
xref: RelationshipXref359
xref: RelationshipXref358
controller: Complex155

UniProt:Q9GR07
type: ProteinReference
xref: UnificationXref4963
organism: BioSource1

UnificationXref564
type: UnificationXref
id: Q8IDS7
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I301
data source: Provenance1
name: Q8I301
name: SUMO-conjugating enzyme UBC9
name: UBC9_HUMAN
name: UBE2I (UBC9)
xref: UnificationXref5775
feature: FragmentFeature1166
cellular location: GO:0005654
comment: Reactome DB_ID: 3657088
display name: UBE2I

UnificationXref561
type: UnificationXref
id: REACT_3923
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3923.2

SUMO1-C173-UBA2
type: Protein
entity reference: Q8I553
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SAE2_HUMAN
name: SUMO-activating enzyme subunit 2
name: SUMO1 S-glycyl-cys173 UBA2
xref: UnificationXref5762
feature: FragmentFeature1165
feature: ModificationFeature71
cellular location: GO:0005654
comment: Reactome DB_ID: 3657066
display name: Q8I553

UnificationXref562
type: UnificationXref
id: Q7YUD6
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IHS2
data source: Provenance1
name: Q8IHS2
name: SUMO-activating enzyme subunit 1
name: SAE1_HUMAN
xref: UnificationXref5759
feature: FragmentFeature1164
cellular location: GO:0005654
comment: Reactome DB_ID: 3657055
display name: SAE1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I553
data source: Provenance1
name: Q8I553
name: SAE2_HUMAN
name: SUMO-activating enzyme subunit 2
xref: UnificationXref5757
feature: FragmentFeature1163
cellular location: GO:0005654
comment: Reactome DB_ID: 3657059
display name: UBA2

UnificationXref560
type: UnificationXref
id: 83910
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83910

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I444
data source: Provenance1
name: Small ubiquitin-related modifier 3
name: SUMO3_HUMAN
name: Q8I444
xref: UnificationXref5751
feature: FragmentFeature1162
cellular location: GO:0005654
comment: Reactome DB_ID: 3657083
display name: SUMO3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I444
data source: Provenance1
name: Small ubiquitin-related modifier 3
name: proSUMO3
name: SUMO3_HUMAN
name: Q8I444
name: SUMO3(1-103)
xref: UnificationXref5750
feature: FragmentFeature1161
cellular location: GO:0005654
comment: Reactome DB_ID: 3657082
display name: SUMO3

http://identifiers.org/pubmed/22112783
type: PublicationXref
id: 22112783
author: Amin, Kawa
db: Pubmed
title: The role of mast cells in allergic inflammation
source: Respir Med 106:9-14
year: 2012

Small ubiquitin-related modifier 2
type: Protein
entity reference: Q8I444
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SUMO2_HUMAN
name: Q8I444
xref: UnificationXref5747
feature: FragmentFeature1160
cellular location: GO:0005654
comment: Reactome DB_ID: 3657080
display name: SUMO2

Small ubiquitin-related modifier 2
type: Protein
entity reference: Q8I444
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: proSUMO2
name: SUMO2_HUMAN
name: SUMO2(1-95)
name: Q8I444
xref: UnificationXref5746
feature: FragmentFeature1159
cellular location: GO:0005654
comment: Reactome DB_ID: 3657079
display name: SUMO2

UniProt:O97319
type: ProteinReference
xref: UnificationXref4009
organism: BioSource1

Catalysis181
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction192
control type: ACTIVATION
xref: RelationshipXref365
xref: RelationshipXref364
controller: Complex158

Catalysis180
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction191
control type: ACTIVATION
xref: RelationshipXref361
xref: RelationshipXref362
controller: Complex157

UniProt:P61076
type: ProteinReference
xref: UnificationXref1817
organism: BioSource1

Catalysis183
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction194
control type: ACTIVATION
xref: RelationshipXref369
xref: RelationshipXref368
controller: Complex159

UnificationXref549
type: UnificationXref
id: 3656546
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656546

Catalysis182
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction193
control type: ACTIVATION
xref: RelationshipXref367
xref: RelationshipXref366
controller: Note: the coordinates are copied over from Homo sapiens.

UniProt:P61074
type: ProteinReference
xref: UnificationXref4714
organism: BioSource1

Catalysis185
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction196
control type: ACTIVATION
xref: RelationshipXref373
xref: RelationshipXref371
controller: Pantothenate kinase 1;3;4

Catalysis184
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction195
control type: ACTIVATION
xref: RelationshipXref371
xref: RelationshipXref372
controller: Note: the coordinates are copied over from Homo sapiens.

UnificationXref556
type: UnificationXref
id: 74113
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74113

Catalysis186
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction197
control type: ACTIVATION
xref: RelationshipXref374
xref: RelationshipXref375
controller: Complex160

UnificationXref557
type: UnificationXref
id: REACT_4155
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4155.2

Catalysis187
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction198
control type: ACTIVATION
xref: RelationshipXref377
xref: RelationshipXref376
controller: Complex161

UniProt:O97321
type: ProteinReference
xref: UnificationXref4291
organism: BioSource1

UnificationXref558
type: UnificationXref
id: 109277
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109277

Catalysis188
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction199
control type: ACTIVATION
xref: RelationshipXref380
xref: RelationshipXref381
controller: Note: the coordinates are copied over from Homo sapiens.

http://identifiers.org/pubmed/16756494
type: PublicationXref
id: 16756494
author: Waterham, HR
author: Wanders, RJ
db: Pubmed
title: Biochemistry of mammalian peroxisomes revisited
source: Annu Rev Biochem 75:295-332
year: 2006

UnificationXref559
type: UnificationXref
id: REACT_5727
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5727.2

Catalysis189
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction200
control type: ACTIVATION
xref: RelationshipXref383
xref: RelationshipXref384
controller: Complex162

UnificationXref552
type: UnificationXref
id: REACT_128558
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128558.5

UnificationXref553
type: UnificationXref
id: 3657421
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657421

UnificationXref554
type: UnificationXref
id: REACT_114890
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114890.8

UnificationXref555
type: UnificationXref
id: CHEBI:29101
db: ChEBI

UnificationXref550
type: UnificationXref
id: 3656547
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656547

UnificationXref551
type: UnificationXref
id: 3656549
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656549

Catalysis152
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction163
control type: ACTIVATION
xref: RelationshipXref313
xref: RelationshipXref314
controller: Complex140

Catalysis151
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction162
control type: ACTIVATION
xref: RelationshipXref310
xref: RelationshipXref309
controller: Complex139

UnificationXref539
type: UnificationXref
id: 3656536
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656536

Catalysis150
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction161
control type: ACTIVATION
xref: RelationshipXref307
xref: RelationshipXref308
controller: Complex135

UnificationXref538
type: UnificationXref
id: 3656535
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656535

UniProt:O96220
type: ProteinReference
xref: UnificationXref4077
organism: BioSource1

UnificationXref543
type: UnificationXref
id: 3656540
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656540

Catalysis159
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction170
control type: ACTIVATION
xref: RelationshipXref327
xref: RelationshipXref328
controller: Complex144

UnificationXref544
type: UnificationXref
id: 3656541
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656541

UnificationXref541
type: UnificationXref
id: 3656538
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656538

Catalysis157
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction168
control type: ACTIVATION
xref: RelationshipXref323
xref: RelationshipXref324
controller: Complex142

UnificationXref542
type: UnificationXref
id: 3656539
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656539

Catalysis158
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction169
control type: ACTIVATION
xref: RelationshipXref325
xref: RelationshipXref326
controller: Complex143

PublicationXref812
type: PublicationXref
id: 0079130356
author: Phang, JM
author: Hu, CA
author: Valle, D
db: ISBN
title: Disorders of proline and hydroxyproline metabolism
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 1821-1838
year: 2001

UnificationXref547
type: UnificationXref
id: 3656544
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656544

Catalysis155
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction166
control type: ACTIVATION
xref: RelationshipXref320
xref: RelationshipXref319
controller: Complex141

UnificationXref548
type: UnificationXref
id: 3656545
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656545

Catalysis156
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction167
control type: ACTIVATION
xref: RelationshipXref321
xref: RelationshipXref322
controller: Complex142

http://identifiers.org/pubmed/19442142
type: PublicationXref
id: 19442142
author: Volpi, N
author: Schiller, J
author: Soltés, L
author: Stern, R
db: Pubmed
title: Role, metabolism, chemical modifications and applications of hyaluronan
source: Curr Med Chem 16:1718-45
year: 2009

UnificationXref545
type: UnificationXref
id: 3656542
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656542

Catalysis153
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction164
control type: ACTIVATION
xref: RelationshipXref316
xref: RelationshipXref315
controller: Complex140

UniProt:O96221
type: ProteinReference
xref: UnificationXref4347
organism: BioSource1

UnificationXref546
type: UnificationXref
id: 3656543
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656543

Catalysis154
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction165
control type: ACTIVATION
xref: RelationshipXref317
xref: RelationshipXref318
controller: Complex140

PublicationXref816
type: PublicationXref
id: 0079130356
author: Shih, VE
author: Chuang, DT
db: ISBN
title: Maple syrup urine disease (branched-chain ketoaciduria)
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 1971-2005
year: 2001

UnificationXref540
type: UnificationXref
id: 3656537
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656537

http://identifiers.org/pubmed/10448521
type: PublicationXref
id: 10448521
author: Seetharam, B
db: Pubmed
title: Receptor-mediated endocytosis of cobalamin (vitamin B12)
source: Annu. Rev. Nutr. 19:173-95
year: 1999

UniProt:O96203
type: ProteinReference
xref: UnificationXref1194
organism: BioSource1

UnificationXref528
type: UnificationXref
id: 3656525
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656525

Catalysis161
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction172
control type: ACTIVATION
xref: RelationshipXref332
xref: RelationshipXref331
controller: Protein675

UnificationXref527
type: UnificationXref
id: 3656524
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656524

Catalysis160
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction171
control type: ACTIVATION
xref: RelationshipXref332
xref: RelationshipXref331
controller: Protein675

http://identifiers.org/pubmed/9335335
type: PublicationXref
id: 9335335
author: Bell, SP
author: Aparicio, OM
author: Weinstein, DM
db: Pubmed
title: Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase.
source: Cell 91:59-69
year: 1997

Catalysis163
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction174
control type: ACTIVATION
xref: RelationshipXref334
xref: RelationshipXref333
controller: Protein676

UnificationXref529
type: UnificationXref
id: 3656526
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656526

Catalysis162
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction173
control type: ACTIVATION
xref: RelationshipXref334
xref: RelationshipXref333
controller: Protein676

cyclic dinucleotide di-GMP
type: SmallMoleculeReference
name: cGpGp
name: c-(GpGp)
name: 3',5'-cyclic di-GMP
name: bis-(3'-5')-cyclic dimeric guanosine monophosphate
name: Guanosine 3',5'-cyclic monophosphate
name: c-di-GMP [ChEBI:49537]
name: guanylyl-(3'->5')-3'-guanylic acid, cyclic 3'->5'''-nucleotide
name: cyclic-bis(3',5')diguanylic acid
name: bis(3',5')-cyclic diguanylic acid
name: c-di-GMP
name: cyclic di-GMP
name: cyclic di-3',5'-guanylic acid
name: cyclic diguanylic acid
name: cyclic-bis(3'->5') dimeric GMP
xref: UnificationXref5873

Porphyrin
type: SmallMoleculeReference
name: Porphyrin [ChEBI:8337]
xref: UnificationXref452

UnificationXref530
type: UnificationXref
id: 3656527
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656527

Catalysis168
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction179
control type: ACTIVATION
xref: RelationshipXref339
xref: RelationshipXref340
controller: Complex148

UnificationXref531
type: UnificationXref
id: 3656528
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656528

Catalysis169
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction180
control type: ACTIVATION
xref: RelationshipXref342
xref: RelationshipXref341
controller: Protein689

UnificationXref532
type: UnificationXref
id: 3656529
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656529

UnificationXref533
type: UnificationXref
id: 3656530
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656530

http://identifiers.org/pubmed/4340992
type: PublicationXref
id: 4340992
author: Fielding, PE
author: Shore, VG
author: Fielding, CJ
db: Pubmed
title: Lecithin: cholesterol acyltransferase: effects of substrate composition upon enzyme activity
source: Biochim Biophys Acta 270:513-8
year: 1972

UnificationXref534
type: UnificationXref
id: 3656531
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656531

Catalysis164
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction175
control type: ACTIVATION
xref: RelationshipXref335
xref: RelationshipXref333
controller: Complex145

UnificationXref535
type: UnificationXref
id: 3656532
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656532

Catalysis165
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction176
control type: ACTIVATION
xref: RelationshipXref335
xref: RelationshipXref333
controller: Complex145

UnificationXref536
type: UnificationXref
id: 3656533
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656533

Catalysis166
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction177
control type: ACTIVATION
xref: RelationshipXref336
xref: RelationshipXref337
controller: Complex146

PublicationXref808
type: PublicationXref
id: 0079130356
author: Simell, O
author: Valle, D
db: ISBN
title: The hyperornithinemias
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 1857-1895
year: 2001

UnificationXref537
type: UnificationXref
id: 3656534
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656534

Catalysis167
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction178
control type: ACTIVATION
xref: RelationshipXref336
xref: RelationshipXref338
controller: Complex147

http://identifiers.org/pubmed/16738331
type: PublicationXref
id: 16738331
author: Itahana, Yoko
author: Yeh, Edward T H
author: Zhang, Yanping
db: Pubmed
title: Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2
source: Mol. Cell. Biol. 26:4675-89
year: 2006

http://identifiers.org/pubmed/17531985
type: PublicationXref
id: 17531985
author: Wittkopp, N
author: Rehwinkel, J
author: Kashima, I
author: Behm-Ansmant, I
author: Izaurralde, E
author: Saulière, J
db: Pubmed
title: mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons
source: FEBS Lett 581:2845-53
year: 2007

http://identifiers.org/pubmed/10970868
type: PublicationXref
id: 10970868
author: Bell, SP
author: Klemm, RD
author: Lee, DG
author: Makhov, AM
db: Pubmed
title: Regulation of origin recognition complex conformation and ATPase activity: differential effects of single-stranded and double-stranded DNA binding.
source: EMBO J 19:4774-82
year: 2000

http://identifiers.org/pubmed/15519848
type: PublicationXref
id: 15519848
author: Reissmann, S
author: Meyer, AS
author: Frydman, J
author: Spiess, C
db: Pubmed
title: Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets
source: Trends Cell Biol 14:598-604
year: 2004

Homologous recombination repair of replication-independent double-strand breaks
type: Pathway
data source: Provenance1
pathway component: Resolution of D-loop structures
pathway component: REACT 76960.9
evidence: Evidence683
xref: UnificationXref5284
xref: UnificationXref5285
pathway order: PathwayStep660
pathway order: PathwayStep663
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/12482854
type: PublicationXref
id: 12482854
author: Horton, JD
author: Moon, YA
db: Pubmed
title: Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade
source: J Biol Chem 278:7335-43
year: 2003

Coproporphyrinogen I
type: SmallMoleculeReference
name: Coproporphyrinogen I [ChEBI:3879]
xref: UnificationXref3458

http://identifiers.org/pubmed/9712840
type: PublicationXref
id: 9712840
author: Kikuchi, Y
author: Mizutani, M
author: Katada, T
author: Imai, M
author: Hoshino, S
author: Hanaoka, F
author: Ui, M
db: Pubmed
title: Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1.
source: J Biol Chem 273:22254-9
year: 1998

http://identifiers.org/pubmed/15534001
type: PublicationXref
id: 15534001
author: Allison, JG
author: Williams, CC
author: Beckman, BS
author: Jones, FE
author: Vidal, GA
author: Burow, ME
author: Marrero, L
db: Pubmed
title: The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
source: J Cell Biol 167:469-78
year: 2004

http://identifiers.org/pubmed/15944408
type: PublicationXref
id: 15944408
author: Waku, K
author: Suzuki, H
author: Kamata, R
author: Yamashita, A
author: Sugiura, T
author: Nakanishi, H
author: Kawagishi, N
db: Pubmed
title: Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)
source: J Biochem 137:557-67
year: 2005

PublicationXref725
type: PublicationXref
id: 0079130356
author: Webster, DR
author: Becroft, DM
author: van Kuilenberg, AB
author: van Gennip, AH
db: ISBN
title: Hereditary orotic aciduria and other disorders of pyrimidine metabolism
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 2663-2704
year: 2001

http://identifiers.org/pubmed/16539657
type: PublicationXref
id: 16539657
author: Kakiuchi, C
author: Hayashi, A
author: Ishiwata, M
author: Kato, T
db: Pubmed
title: XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells
source: J Neurochem 97:545-55
year: 2006

http://identifiers.org/pubmed/10834843
type: PublicationXref
id: 10834843
author: Tercero, JA
author: Labib, K
author: Diffley, JF
db: Pubmed
title: Uninterrupted MCM2-7 function required for DNA replication fork progression.
source: Science 288:1643-7
year: 2000

http://identifiers.org/pubmed/11896061
type: PublicationXref
id: 11896061
author: Hang, Jun
author: Dasso, Mary
db: Pubmed
title: Association of the human SUMO-1 protease SENP2 with the nuclear pore
source: J. Biol. Chem. 277:19961-6
year: 2002

PKA-mediated phosphorylation of CREB
type: Pathway
data source: Provenance1
pathway component: PKA activation
evidence: Evidence9
xref: UnificationXref180
xref: UnificationXref181
pathway order: PathwayStep8
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/15489917
type: PublicationXref
id: 15489917
author: Gauld, SB
author: Cambier, JC
db: Pubmed
title: Src-family kinases in B-cell development and signaling
source: Oncogene 23:8001-6
year: 2004

http://identifiers.org/pubmed/8257433
type: PublicationXref
id: 8257433
author: Hopkinson, DA
author: Edwards, YH
author: Whitehouse, DB
author: Ives, JH
author: Hollyoake, M
author: Putt, W
db: Pubmed
title: Phosphoglucomutase 1: a gene with two promoters and a duplicated first exon
source: Biochem J 296:417-22
year: 1993

PublicationXref750
type: PublicationXref
id: 0121227022
author: Parks, Jr, RE
author: Agarwal, RP
db: ISBN
title: Nucleoside diphosphokinases
source: The Enzymes, 3rd ed (Book): 307-333
year: 1973

PublicationXref754
type: PublicationXref
id: 0121227022
author: Anderson, EP
db: ISBN
title: Nucleoside and nucleotide kinases
source: The Enzymes, 3rd ed (Book): 49-96
year: 1973

PublicationXref756
type: PublicationXref
id: 0121227022
author: Noda, L
db: ISBN
title: Adenylate kinase
source: The Enzymes, 3rd ed (Book): 279-305
year: 1973

SHC1 events in ERBB4 signaling
type: Pathway
data source: Provenance1
pathway component: REACT 157443.3
evidence: Evidence827
xref: UnificationXref6025
xref: UnificationXref6024
pathway order: PathwayStep16
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Cytosolic sensors of pathogen-associated DNA
type: Pathway
data source: Provenance1
pathway component: REACT 166349.1
evidence: Evidence783
xref: UnificationXref5892
xref: UnificationXref5893
xref: RelationshipXref639
pathway order: PathwayStep757
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/18327257
type: PublicationXref
id: 18327257
author: Gray, NK
author: Hayward, C
author: Marinaki, A
author: Hastie, ND
author: Fairbanks, LD
author: Gorgoni, B
author: Skaric-Juric, T
author: Knott, SA
author: Shu, X
author: Pericic, M
author: Ralston, SH
author: Aringer, M
author: Barac-Lauc, L
author: Klaric, IM
author: Rudan, P
author: Riches, PL
author: Wilson, JF
author: Smolej-Narancic, N
author: Wright, AF
author: Kimber, CH
author: Palmer, CN
author: Rudan, I
author: Kolcic, I
author: Morgan, J
author: Biloglav, Z
author: Morris, AD
author: Hohenstein, P
author: Richardson, WA
author: Tenesa, A
author: Wild, SH
author: McKeigue, PM
author: Vitart, V
author: Donnelly, LA
author: Janicijevic, B
author: Zgaga, L
author: Campbell, H
author: Graessler, J
author: Floyd, J
author: Campbell, S
author: Polasek, O
db: Pubmed
title: SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
source: Nat Genet 40:437-42
year: 2008

http://identifiers.org/pubmed/12474143
type: PublicationXref
id: 12474143
author: Carlson, Christopher G
author: Hoffbuhr, Kristen C
author: Kennaway, Nancy G
author: Glerum, D Moira
author: Antonicka, Hana
author: Leary, Scot C
author: Shoubridge, EA
author: Mattman, Andre
db: Pubmed
title: Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy
source: Am. J. Hum. Genet. 72:101-14
year: 2003

http://identifiers.org/pubmed/8619816
type: PublicationXref
id: 8619816
author: Kondo, M
author: Itakura, M
author: Takahashi, Y
author: Moritani, M
author: Yoshimoto, K
author: Yamaoka, T
author: Fujimura, H
author: Ii, S
author: Iwahana, H
db: Pubmed
title: Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis
source: Biochem Biophys Res Commun 219:249-255
year: 1996

http://identifiers.org/pubmed/7909354
type: PublicationXref
id: 7909354
author: Melki, R
author: Cowan, NJ
db: Pubmed
title: Facilitated folding of actins and tubulins occurs via a nucleotide-dependent interaction between cytoplasmic chaperonin and distinctive folding intermediates
source: Mol Cell Biol 14:2895-904
year: 1994

http://identifiers.org/pubmed/9697839
type: PublicationXref
id: 9697839
author: Turck, CW
author: Kurosaki, T
author: Chan, AC
author: Fu, C
db: Pubmed
title: BLNK: a central linker protein in B cell activation
source: Immunity 9:93-103
year: 1998

Synthesis of PC
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction119
pathway component: BiochemicalReaction113
pathway component: BiochemicalReaction118
pathway component: BiochemicalReaction117
evidence: Evidence243
xref: RelationshipXref219
xref: UnificationXref2033
xref: UnificationXref2034
pathway order: PathwayStep236
pathway order: PathwayStep235
pathway order: PathwayStep229
pathway order: PathwayStep237
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2889
type: UnificationXref
id: 3654309
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654309

UnificationXref2888
type: UnificationXref
id: 3654308
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654308

UnificationXref2895
type: UnificationXref
id: 3654313
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654313

UnificationXref2896
type: UnificationXref
id: REACT_155920
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155920.3

UnificationXref2897
type: UnificationXref
id: 3654314
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654314

UnificationXref2898
type: UnificationXref
id: 3654315
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654315

UnificationXref2891
type: UnificationXref
id: Q8IL94
db: UniProt

UnificationXref2892
type: UnificationXref
id: 3654299
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654299

UnificationXref2893
type: UnificationXref
id: 3654300
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654300

secretory granule membrane
type: CellularLocationVocabulary
xref: UnificationXref703

UnificationXref2894
type: UnificationXref
id: 3654311
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654311

http://identifiers.org/pubmed/9450929
type: PublicationXref
id: 9450929
author: Buratowski, S
author: Hartzog, GA
author: Hirose, S
author: Sugimoto, S
author: Yamaguchi, Y
author: Winston, F
author: Ferdous, A
author: Imai, T
author: Takagi, T
author: Wada, T
author: Handa, H
author: Yano, K
db: Pubmed
title: DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.
source: Genes Dev 12:343-56
year: 1998

UnificationXref2890
type: UnificationXref
id: 3654310
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654310

Golgi-associated vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref4521

UnificationXref2899
type: UnificationXref
id: CHEBI:16284
db: ChEBI

3-decaprenyl-4-hydroxybenzoic acid
type: SmallMoleculeReference
name: 3-decaprenyl-4-hydroxybenzoic acid [ChEBI:64136]
xref: UnificationXref2312

http://identifiers.org/pubmed/16978839
type: PublicationXref
id: 16978839
author: Mei, Y
author: Zhou, M
author: Liu, X
author: Li, Z
db: Pubmed
title: Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners
source: Cell Signal 19:466-71
year: 2007

phagocytic vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref8

synaptic vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref694

http://identifiers.org/pubmed/12369887
type: PublicationXref
id: 12369887
author: Danielson, PB
db: Pubmed
title: The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans
source: Curr Drug Metab 3:561-97
year: 2002

UnificationXref2867
type: UnificationXref
id: 3654287
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654287

UnificationXref2866
type: UnificationXref
id: Q7KXR4
db: UniProt

UnificationXref2869
type: UnificationXref
id: 499930
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=499930

UnificationXref2868
type: UnificationXref
id: 3654288
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654288

http://identifiers.org/pubmed/10692433
type: PublicationXref
id: 10692433
author: Kijima, S
author: Fujita, M
author: Arata, Y
author: Ohtani, K
author: Kato, JY
db: Pubmed
title: Cdk2-dependent and -independent pathways in E2F-mediated S phase induction
source: J Biol Chem 275:6337-45
year: 2000

UnificationXref2870
type: UnificationXref
id: REACT_22084
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22084.1

Metabolism of lipids and lipoproteins
type: Pathway
data source: Provenance1
pathway component: Peroxisomal lipid metabolism
pathway component: REACT 34689.10
pathway component: REACT 97355.9
pathway component: REACT 79244.9
pathway component: Sphingolipid metabolism
pathway component: REACT 147148.5
pathway component: REACT 139882.5
pathway component: REACT 90141.9
pathway component: REACT 162640.2
pathway component: REACT 92234.9
evidence: Evidence290
xref: UnificationXref2357
xref: UnificationXref2358
pathway order: PathwayStep273
pathway order: PathwayStep278
pathway order: PathwayStep215
pathway order: PathwayStep218
pathway order: PathwayStep284
pathway order: PathwayStep264
pathway order: PathwayStep211
pathway order: PathwayStep255
pathway order: PathwayStep183
pathway order: PathwayStep221
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2871
type: UnificationXref
id: MOD:00798
db: MOD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q2V2M6
data source: Provenance1
name: Q2V2M6
name: Phosphodiesterase 5A
name: PDE5A_HUMAN
name: cGMP-specific 3',5'-cyclic phosphodiesterase 5A
xref: UnificationXref5583
feature: FragmentFeature1081
cellular location: GO:0005829
comment: Reactome DB_ID: 3655628
display name: PDE5A

UnificationXref2872
type: UnificationXref
id: 3654291
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654291

UnificationXref2873
type: UnificationXref
id: 3654294
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654294

UnificationXref2874
type: UnificationXref
id: 3654295
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654295

http://identifiers.org/pubmed/8723348
type: PublicationXref
id: 8723348
author: Jefferson, AB
author: Pot, DA
author: Deuter-Reinhard, M
author: Masiarz, FR
author: Cousens, LS
author: Williams, LT
author: Chin, SM
author: Norris, FA
author: Kavanaugh, WM
author: Majerus, PW
db: Pubmed
title: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
source: Curr Biol 6:438-45
year: 1996

UnificationXref2875
type: UnificationXref
id: CHEBI:16174
db: ChEBI

http://identifiers.org/pubmed/3932573
type: PublicationXref
id: 3932573
author: Kuhl, W
author: Beutler, E
db: Pubmed
title: Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism
source: J Lab Clin Med 106:573-7
year: 1985

UnificationXref2876
type: UnificationXref
id: 110090
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110090

UniProt:Q95Z60
type: ProteinReference
xref: UnificationXref3540
organism: BioSource1

http://identifiers.org/pubmed/1894595
type: PublicationXref
id: 1894595
author: Burbaum, JJ
author: Schimmel, P
db: Pubmed
title: Structural relationships and the classification of aminoacyl-tRNA synthetases
source: J Biol Chem 266:16965-8
year: 1991

http://identifiers.org/pubmed/17139329
type: PublicationXref
id: 17139329
author: Rosen, ED
author: MacDougald, OA
db: Pubmed
title: Adipocyte differentiation from the inside out
source: Nat Rev Mol Cell Biol 7:885-96
year: 2006

UnificationXref2879
type: UnificationXref
id: REACT_21937
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21937.1

UnificationXref2878
type: UnificationXref
id: 499933
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=499933

UnificationXref2877
type: UnificationXref
id: REACT_4457
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4457.2

UnificationXref2882
type: UnificationXref
id: REACT_5725
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5725.2

carbovir monophosphate [ChEBI:64116]
type: SmallMoleculeReference
name: carbovir monophosphate
xref: UnificationXref3615

UnificationXref2883
type: UnificationXref
id: Q8IM38
db: UniProt

UnificationXref2880
type: UnificationXref
id: CHEBI:29034
db: ChEBI

UnificationXref2881
type: UnificationXref
id: 111736
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111736

UnificationXref2886
type: UnificationXref
id: 3654306
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654306

UnificationXref2887
type: UnificationXref
id: Q9U428
db: UniProt

UnificationXref2884
type: UnificationXref
id: 3654304
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654304

http://identifiers.org/pubmed/11815463
type: PublicationXref
id: 11815463
author: Sharp, GW
author: Liu, YJ
author: Gunawardana, S
author: Straub, SG
author: Mulvaney-Musa, J
author: Cheng, H
author: Schermerhorn, T
author: Yajima, H
author: Daniel, S
author: Bratanova-Tochkova, TK
db: Pubmed
title: Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion
source: Diabetes 51:S83-90
year: 2002

UnificationXref2885
type: UnificationXref
id: Q9U423
db: UniProt

UnificationXref2848
type: UnificationXref
id: 3653710
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653710

UnificationXref2849
type: UnificationXref
id: Q9TX46
db: UniProt

UnificationXref2844
type: UnificationXref
id: CHEBI:15713
db: ChEBI

UnificationXref2845
type: UnificationXref
id: 29494
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29494

UnificationXref2846
type: UnificationXref
id: REACT_3409
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3409.1

UnificationXref2847
type: UnificationXref
id: Q8ILZ3
db: UniProt

Transport to the Golgi and subsequent modification
type: Pathway
data source: Provenance1
pathway component: REACT 77471.9
evidence: Evidence532
xref: UnificationXref4390
xref: UnificationXref4389
pathway order: PathwayStep518
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2852
type: UnificationXref
id: 3653714
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653714

UnificationXref2851
type: UnificationXref
id: Q27725
db: UniProt

UnificationXref2854
type: UnificationXref
id: 3653716
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653716

UnificationXref2853
type: UnificationXref
id: 3653715
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653715

UnificationXref2850
type: UnificationXref
id: 3653712
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653712

UnificationXref2859
type: UnificationXref
id: 3656031
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656031

UnificationXref2857
type: UnificationXref
id: 3656029
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656029

UnificationXref2858
type: UnificationXref
id: 3656030
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656030

UnificationXref2855
type: UnificationXref
id: 3653718
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653718

http://identifiers.org/pubmed/8167409
type: PublicationXref
id: 8167409
author: McMahon, Jill A
author: Smolich, Beverly D
author: McMahon, Andrew P
author: Papkoff, Jackie
db: Pubmed
title: Wnt family proteins are secreted and associated with the cell surface
source: Mol. Biol. Cell 4:1267-75
year: 1993

UnificationXref2856
type: UnificationXref
id: REACT_77819
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77819.9

http://identifiers.org/pubmed/3143362
type: PublicationXref
id: 3143362
author: Sakuraba, H
author: Nagao, Y
author: Suzuki, Y
author: Tsuji, A
author: Oshima, A
db: Pubmed
title: Cloning, sequencing, and expression of cDNA for human beta-galactosidase
source: Biochem. Biophys. Res. Commun. 157:238-44
year: 1988

UnificationXref2865
type: UnificationXref
id: 3654285
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654285

UnificationXref2864
type: UnificationXref
id: Q9NLB2
db: UniProt

UnificationXref2863
type: UnificationXref
id: REACT_108024
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108024.9

UnificationXref2862
type: UnificationXref
id: 3656035
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656035

UnificationXref2861
type: UnificationXref
id: 3656033
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656033

UnificationXref2860
type: UnificationXref
id: 3656032
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656032

http://identifiers.org/pubmed/9110970
type: PublicationXref
id: 9110970
author: Lingner, J
author: Shevchenko, A
author: Hughes, TR
author: Lundblad, V
author: Mann, M
author: Cech, TR
db: Pubmed
title: Reverse transcriptase motifs in the catalytic subunit of telomerase
source: Science 276:561-7
year: 1997

UnificationXref2822
type: UnificationXref
id: 3653604
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653604

UnificationXref2823
type: UnificationXref
id: 3653606
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653606

UnificationXref2824
type: UnificationXref
id: REACT_103412
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103412.9

UnificationXref2825
type: UnificationXref
id: 3654008
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654008

UnificationXref2826
type: UnificationXref
id: REACT_34334
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34334.10

UnificationXref2827
type: UnificationXref
id: 499997
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=499997

UnificationXref2828
type: UnificationXref
id: REACT_21666
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21666.1

UnificationXref2829
type: UnificationXref
id: CHEBI:28850
db: ChEBI

UnificationXref2830
type: UnificationXref
id: 110093
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110093

UnificationXref2832
type: UnificationXref
id: CHEBI:18075
db: ChEBI

UnificationXref2831
type: UnificationXref
id: REACT_5210
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5210.2

UnificationXref2835
type: UnificationXref
id: 499999
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=499999

UnificationXref2836
type: UnificationXref
id: REACT_21449
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21449.1

UnificationXref2833
type: UnificationXref
id: 110095
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110095

UnificationXref2834
type: UnificationXref
id: REACT_2972
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2972.2

UnificationXref2839
type: UnificationXref
id: 3653704
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653704

http://identifiers.org/pubmed/17008356
type: PublicationXref
id: 17008356
author: Monroy, N
author: Kretz, C
author: Mandel, JL
author: Payrastre, B
author: Dondaine, N
author: Tronchère, H
author: Zanoteli, E
author: Rohde, HM
author: Tosch, V
author: Laporte, J
db: Pubmed
title: A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy
source: Hum Mol Genet 15:3098-106
year: 2006

UnificationXref2837
type: UnificationXref
id: Q8I4S1
db: UniProt

UnificationXref2838
type: UnificationXref
id: 3653703
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653703

http://identifiers.org/pubmed/8325892
type: PublicationXref
id: 8325892
author: Froguel, P
author: Velho, G
author: Stoffel, M
author: Vionnet, N
author: Cohen, D
author: Takeda, J
author: St. Charles, R
author: Bell, GI
author: Vaxillaire, M
author: Pilkis, SJ
author: Weber, IT
author: Gidh-Jain, M
author: Shimada, F
author: Nishi, S
author: Harrison, RW
author: Makino, H
author: Xu, LZ
db: Pubmed
title: Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants.
source: J Biol Chem 268:15200-4
year: 1993

http://identifiers.org/pubmed/19855401
type: PublicationXref
id: 19855401
author: Wilkinson, RJ
author: Boshoff, HI
author: Young, D
author: Dartois, V
author: Ehrt, S
author: Flynn, J
author: Barry CE, 3rd
author: Schnappinger, D
author: Dick, T
db: Pubmed
title: The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
source: Nat Rev Microbiol 7:845-55
year: 2009

http://identifiers.org/pubmed/22649417
type: PublicationXref
id: 22649417
author: Siddle, Kenneth
db: Pubmed
title: Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances
source: Front Endocrinol (Lausanne) 3:34
year: 2012

http://identifiers.org/pubmed/15632136
type: PublicationXref
id: 15632136
author: Kinoshita, T
author: Ashida, H
author: Shishioh, N
author: Hong, Y
author: Maeda, Y
author: Ohishi, K
db: Pubmed
title: GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol
source: J Biol Chem 280:9728-34
year: 2005

UnificationXref2843
type: UnificationXref
id: REACT_79157
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79157.9

UnificationXref2842
type: UnificationXref
id: 3654009
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654009

5-PP-InsP5
type: SmallMoleculeReference
name: 5-PP-InsP5 [ChEBI:2119]
name: 5-Diphosphoinositol pentakisphosphate
xref: UnificationXref1518

UnificationXref2841
type: UnificationXref
id: REACT_103892
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103892.9

UnificationXref2840
type: UnificationXref
id: 3653706
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653706

UnificationXref621
type: UnificationXref
id: REACT_155454
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155454.3

UnificationXref620
type: UnificationXref
id: 3655912
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655912

UniProt:P24044
type: ProteinReference
xref: UnificationXref123
organism: BioSource1

UnificationXref623
type: UnificationXref
id: REACT_157940
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157940.3

UniProt:O96145
type: ProteinReference
xref: UnificationXref2343
organism: BioSource1

UnificationXref622
type: UnificationXref
id: 3655913
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655913

UnificationXref625
type: UnificationXref
id: 30537
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30537

UnificationXref624
type: UnificationXref
id: CHEBI:17665
db: ChEBI

Homologues of OGG1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5124
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654198

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6SCL5
data source: Provenance1
name: N-glycosylase/DNA lyase
name: N-glycosylase/DNA lyase (Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase))
name: AP lyase
name: Q6SCL5
name: DNA-(apurinic or apyrimidinic site) lyase
name: 8-oxoguanine DNA glycosylase
xref: UnificationXref5121
feature: FragmentFeature1043
cellular location: GO:0005654
comment: Reactome DB_ID: 3654195
display name: OGG1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I2Y2
data source: Provenance1
name: Q8I2Y2
name: N-glycosylase/DNA lyase
name: N-glycosylase/DNA lyase (Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase))
name: AP lyase
name: DNA-(apurinic or apyrimidinic site) lyase
name: 8-oxoguanine DNA glycosylase
xref: UnificationXref5123
feature: FragmentFeature1044
cellular location: GO:0005654
comment: Reactome DB_ID: 3654197
display name: OGG1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C6KSY9
data source: Provenance1
name: C6KSY9
name: Endonuclease III-like protein 1 (EC 4.2.99.18)
name: hNTH1
name: Endonuclease III-like protein 1
xref: UnificationXref5171
feature: FragmentFeature1045
cellular location: GO:0005654
comment: Reactome DB_ID: 3654177
display name: NTHL1

O97240
type: Protein
entity reference: UniProt:O97240
data source: Provenance1
xref: UnificationXref5215
cellular location: GO:0005654
comment: Reactome DB_ID: 3654239

http://identifiers.org/pubmed/7306699
type: PublicationXref
id: 7306699
author: Plow, EF
db: Pubmed
title: The presence and release of alpha 2-antiplasmin from human platelets
source: Blood 58:1069-74
year: 1981

Homologues of FEN1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5243
cellular location: GO:0005654
comment: Reactome DB_ID: 3654254
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7K734
data source: Provenance1
name: Q7K734
name: Maturation factor 1
name: FEN1
name: Flap endonuclease-1
xref: UnificationXref5240
feature: FragmentFeature1046
cellular location: GO:0005654
comment: Reactome DB_ID: 3654251
display name: MF1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IJR8
data source: Provenance1
name: Q8IJR8
name: FCP1P protein
xref: UnificationXref5080
feature: FragmentFeature1040
cellular location: GO:0005654
comment: Reactome DB_ID: 3654365
display name: CTDP1

phospho-p-SUPT5H
type: Protein
entity reference: C6KSV4
data source: Provenance1
xref: UnificationXref5073
feature: FragmentFeature1039
feature: ModificationFeature65
cellular location: GO:0005654
comment: Reactome DB_ID: 3654374

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8II68
data source: Provenance1
name: Q8II68
name: MYH glycosylase
xref: UnificationXref5114
feature: FragmentFeature1042
cellular location: GO:0005654
comment: Reactome DB_ID: 3654206
display name: MUTYH

3-alkyladenine DNA glycosylase
type: Protein
entity reference: Q8IKG6
data source: Provenance1
name: ADPG
name: Note: the coordinates are copied over from Homo sapiens.
name: DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-methyladenine DNA glycosidase) (ADPG) (3-alkyladenine DNA glycosylase) (N-methylpurine- DNA glycosirase)
name: 3-methyladenine DNA glycosidase
name: MPG glycosylase
name: N-methylpurine- DNA glycosirase
name: DNA-3-methyladenine glycosylase
name: Q8IKG6
xref: UnificationXref5097
feature: FragmentFeature1041
cellular location: GO:0005654
comment: Reactome DB_ID: 3654212
display name: MPG

UnificationXref615
type: UnificationXref
id: 3655915
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655915

UnificationXref616
type: UnificationXref
id: REACT_156029
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156029.3

UnificationXref617
type: UnificationXref
id: 139836
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=139836

UnificationXref618
type: UnificationXref
id: REACT_2541
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2541.1

UnificationXref619
type: UnificationXref
id: 3655911
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655911

UnificationXref610
type: UnificationXref
id: 3652826
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652826

UniProt:O96130
type: ProteinReference
xref: UnificationXref2300
organism: BioSource1

UnificationXref614
type: UnificationXref
id: REACT_155313
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155313.3

UniProt:O96136
type: ProteinReference
xref: UnificationXref5292
organism: BioSource1

UnificationXref613
type: UnificationXref
id: 3652834
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652834

UnificationXref612
type: UnificationXref
id: 3652832
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652832

UnificationXref611
type: UnificationXref
id: 3652827
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652827

O96136
type: Protein
entity reference: UniProt:O96136
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ERCC1, DNA excision repair protein
name: DNA excision repair protein ERCC-1
xref: UnificationXref5293
feature: FragmentFeature1051
cellular location: GO:0005654
comment: Reactome DB_ID: 3654148
display name: ERCC1

http://identifiers.org/pubmed/1939222
type: PublicationXref
id: 1939222
author: Cox, TM
author: Gardner, LC
author: Smith, SJ
db: Pubmed
title: Biosynthesis of delta-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in man
source: J Biol Chem 266:22010-8
year: 1991

Homologues of p-S2,S5-POLR2A
type: Protein
data source: Provenance1
member physical entity: phospho-p-S2,S5-POLR2A
xref: UnificationXref5316
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654165

http://identifiers.org/pubmed/12655297
type: PublicationXref
id: 12655297
author: Janicke, RU
author: Schulze-Osthoff, K
author: Fischer, U
db: Pubmed
title: Many cuts to ruin: a comprehensive update of caspase substrates
source: Cell Death Differ 10:76-100
year: 2003

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IIS8
data source: Provenance1
name: HsRAD51
name: Q8IIS8
name: DNA repair protein RAD51 homolog 1
name: DNA repair protein RAD51 homolog 1 (hRAD51) (HsRAD51)
name: hRAD51
xref: UnificationXref5263
feature: FragmentFeature1049
cellular location: GO:0005654
comment: Reactome DB_ID: 3654122
display name: RAD51

Q8ID22
type: Protein
entity reference: UniProt:Q8ID22
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: XPF protein
name: DNA excision repair protein ERCC-4
name: DNA-repair protein complementing XP-F cell
name: DNA-repair protein complementing XP-F cell (Xeroderma pigmentosum group F complementing protein) (DNA excision repair protein ERCC-4)
name: Xeroderma pigmentosum group F complementing protein
xref: UnificationXref5291
feature: FragmentFeature1050
cellular location: GO:0005654
comment: Reactome DB_ID: 3654152
display name: ERCC4

phospho-p-S2,S5-POLR2A
type: Protein
entity reference: C6F0B0
data source: Provenance1
xref: UnificationXref5313
feature: ModificationFeature57
feature: FragmentFeature1054
feature: ModificationFeature68
cellular location: GO:0005654
comment: Reactome DB_ID: 3654160

phospho-p-S2,S5-POLR2A
type: Protein
entity reference: C6F0A4
data source: Provenance1
xref: UnificationXref5314
feature: ModificationFeature69
feature: ModificationFeature58
feature: FragmentFeature1055
cellular location: GO:0005654
comment: Reactome DB_ID: 3654162

phospho-p-S2,S5-POLR2A
type: Protein
entity reference: C6F0A3
data source: Provenance1
xref: UnificationXref5311
feature: FragmentFeature1052
feature: ModificationFeature66
feature: ModificationFeature55
cellular location: GO:0005654
comment: Reactome DB_ID: 3654156

phospho-p-S2,S5-POLR2A
type: Protein
entity reference: O77375
data source: Provenance1
xref: UnificationXref5312
feature: FragmentFeature1053
feature: ModificationFeature56
feature: ModificationFeature67
cellular location: GO:0005654
comment: Reactome DB_ID: 3654158

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I9U4
data source: Provenance1
name: HsRAD51
name: Q8I9U4
name: DNA repair protein RAD51 homolog 1
name: DNA repair protein RAD51 homolog 1 (hRAD51) (HsRAD51)
name: hRAD51
xref: UnificationXref5261
feature: FragmentFeature1048
cellular location: GO:0005654
comment: Reactome DB_ID: 3654120
display name: RAD51

Homologues of RAD51
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5264
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654123

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q9GZ01
data source: Provenance1
name: Maturation factor 1
name: Q9GZ01
name: FEN1
name: Flap endonuclease-1
xref: UnificationXref5242
feature: FragmentFeature1047
cellular location: GO:0005654
comment: Reactome DB_ID: 3654253
display name: MF1

UnificationXref606
type: UnificationXref
id: 3652818
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652818

UnificationXref607
type: UnificationXref
id: 3652819
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652819

UnificationXref604
type: UnificationXref
id: 3652815
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652815

UnificationXref605
type: UnificationXref
id: 3652817
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652817

UnificationXref608
type: UnificationXref
id: 3652824
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652824

UnificationXref609
type: UnificationXref
id: 3652825
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652825

UnificationXref645
type: UnificationXref
id: 428819
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428819

UnificationXref644
type: UnificationXref
id: REACT_158627
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158627.3

UnificationXref647
type: UnificationXref
id: 428802
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428802

http://identifiers.org/pubmed/1908722
type: PublicationXref
id: 1908722
author: Poncz, M
author: Manning, DR
author: Brass, LF
author: Gagnon, AW
author: Gewirtz, A
author: Catani, L
db: Pubmed
title: Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes
source: Blood 78:1247-53
year: 1991

UnificationXref646
type: UnificationXref
id: REACT_19505
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19505.1

UnificationXref641
type: UnificationXref
id: REACT_94923
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94923.9

UnificationXref640
type: UnificationXref
id: 3657181
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657181

UnificationXref643
type: UnificationXref
id: 3655726
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655726

UnificationXref642
type: UnificationXref
id: 3655724
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655724

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I512
data source: Provenance1
name: Replication factor C 40 kDa subunit
name: RFC40
name: A1 40 kDa subunit
name: Q8I512
name: RF-C 40 kDa subunit
name: Activator 1 40 kDa subunit
xref: UnificationXref4969
feature: FragmentFeature1028
cellular location: GO:0005654
comment: Reactome DB_ID: 3652742
display name: RFC2

http://identifiers.org/pubmed/10753735
type: PublicationXref
id: 10753735
author: Leroux, MR
author: Hartl, FU
db: Pubmed
title: Protein folding: versatility of the cytosolic chaperonin TRiC/CCT
source: Curr Biol 10:R260-4
year: 2000

Q8WSL8
type: Protein
entity reference: Q8WSL8
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Replication factor C 40 kDa subunit
name: RFC40
name: A1 40 kDa subunit
name: RF-C 40 kDa subunit
name: Activator 1 40 kDa subunit
xref: UnificationXref4971
feature: FragmentFeature1029
cellular location: GO:0005654
comment: Reactome DB_ID: 3652744
display name: RFC2

Homologues of RFC5
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q8IKK4
xref: UnificationXref4977
cellular location: GO:0005654
comment: Reactome DB_ID: 3652724
comment: Converted from EntitySet in Reactome

http://identifiers.org/pubmed/18240029
type: PublicationXref
id: 18240029
author: Luttrell, LM
db: Pubmed
title: Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors
source: Mol Biotechnol 39:239-64
year: 2008

Q8IKK4
type: Protein
entity reference: Q8IKK4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Replication factor C subunit 5
name: Activator 1 36 kDa subunit
name: A1 36 kDa subunit
name: RF-C 36 kDa subunit
name: RFC36
name: Activator 1 36 kDa subunit (Replication factor C 36 kDa subunit) (A1 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)
name: Replication factor C 36 kDa subunit
xref: UnificationXref4974
feature: FragmentFeature1030
cellular location: GO:0005654
comment: Reactome DB_ID: 3652721
display name: RFC5

Homologues of RFC2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q8WSL8
xref: UnificationXref4972
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652745

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O96260
data source: Provenance1
name: O96260
name: RF-C 37 kDa subunit
name: A1 37 kDa subunit
name: RFC37
name: Replication factor C 37 kDa subunit
name: Activator 1 37 kDa subunit
xref: UnificationXref4966
feature: FragmentFeature1027
cellular location: GO:0005654
comment: Reactome DB_ID: 3652730
display name: RFC4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q9GR07
data source: Provenance1
name: Q9GR07
name: RF-C 37 kDa subunit
name: A1 37 kDa subunit
name: RFC37
name: Replication factor C 37 kDa subunit
name: Activator 1 37 kDa subunit
xref: UnificationXref4964
feature: FragmentFeature1026
cellular location: GO:0005654
comment: Reactome DB_ID: 3652728
display name: RFC4

http://identifiers.org/pubmed/8325954
type: PublicationXref
id: 8325954
author: Ciaraldi, TP
author: Hueckstaedt, TP
author: Wilkinson, W
author: Olefsky, JM
author: Garvey, WT
author: Pilch, PF
db: Pubmed
title: Insulin-responsive human adipocytes express two glucose transporter isoforms and target them to different vesicles
source: J Clin Endocrinol Metab 77:286-9
year: 1993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8I5T4
data source: Provenance1
name: CDC46 homolog
name: Q8I5T4
name: P1-CDC46
name: DNA replication licensing factor MCM5
name: Mcm5
xref: UnificationXref4943
feature: FragmentFeature1024
cellular location: GO:0005654
comment: Reactome DB_ID: 3652696
display name: MCM5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8WSL5
data source: Provenance1
name: CDC46 homolog
name: Q8WSL5
name: P1-CDC46
name: DNA replication licensing factor MCM5
name: Mcm5
xref: UnificationXref4941
feature: FragmentFeature1023
cellular location: GO:0005654
comment: Reactome DB_ID: 3652694
display name: MCM5

Homologues of RFC4
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4967
cellular location: GO:0005654
comment: Reactome DB_ID: 3652731
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8I5T7
data source: Provenance1
name: Q8I5T7
name: DNA helicase MCM8
name: MCM8_HUMAN
xref: UnificationXref4958
feature: FragmentFeature1025
cellular location: GO:0005654
comment: Reactome DB_ID: 3654668
display name: MCM8

UnificationXref637
type: UnificationXref
id: REACT_100137
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100137.9

UnificationXref638
type: UnificationXref
id: 3657180
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657180

UnificationXref639
type: UnificationXref
id: REACT_79607
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79607.9

http://identifiers.org/pubmed/14739288
type: PublicationXref
id: 14739288
author: Dowd, LO
author: Augustin, R
author: Phay, JE
author: Moley, JF
author: Moley, KH
author: Carayannopoulos, MO
db: Pubmed
title: Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking
source: J Biol Chem 279:16229-36
year: 2004

http://identifiers.org/pubmed/16321791
type: PublicationXref
id: 16321791
author: Joseph, JW
author: MacDonald, PE
author: Rorsman, P
db: Pubmed
title: Glucose-sensing mechanisms in pancreatic beta-cells
source: Philos Trans R Soc Lond B Biol Sci 360:2211-25
year: 2005

UnificationXref636
type: UnificationXref
id: 3657361
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657361

UnificationXref635
type: UnificationXref
id: REACT_118209
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118209.7

UnificationXref634
type: UnificationXref
id: 3654674
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654674

UnificationXref633
type: UnificationXref
id: 3654673
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654673

UnificationXref632
type: UnificationXref
id: GO:0005654
db: GENE ONTOLOGY

UnificationXref631
type: UnificationXref
id: REACT_34118
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34118.10

UnificationXref630
type: UnificationXref
id: 3652843
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652843

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8WQK1
data source: Provenance1
name: DNA ligase I
name: Polydeoxyribonucleotide synthase (ATP)
name: Q8WQK1
xref: UnificationXref5010
feature: FragmentFeature1037
cellular location: GO:0005654
comment: Reactome DB_ID: 3652777
display name: LIG1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IJA5
data source: Provenance1
name: SPT4H1 protein
name: Transcription initiation protein SPT4 homolog 1
name: SUPT4H1
xref: UnificationXref5071
feature: FragmentFeature1038
cellular location: GO:0005654
comment: Reactome DB_ID: 3654369
display name: Q8IJA5

Homologues of LIG1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5011
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652778

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IES4
data source: Provenance1
name: DNA ligase I
name: Polydeoxyribonucleotide synthase (ATP)
name: Q8IES4
xref: UnificationXref5008
feature: FragmentFeature1036
cellular location: GO:0005654
comment: Reactome DB_ID: 3652775
display name: LIG1

Q9GQW6
type: Protein
entity reference: UniProt:Q9GQW6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DNA-binding protein PO-GA
name: Activator 1 140 kDa subunit
name: RFC140
name: RF-C 140 kDa subunit
name: Activator 1 large subunit
name: A1 140 kDa subunit
name: Replication factor C large subunit
xref: UnificationXref4984
feature: FragmentFeature1034
cellular location: GO:0005654
comment: Reactome DB_ID: 3652749
display name: RFC1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O96271
data source: Provenance1
name: DNA-binding protein PO-GA
name: Activator 1 140 kDa subunit
name: RFC140
name: O96271
name: RF-C 140 kDa subunit
name: Activator 1 large subunit
name: A1 140 kDa subunit
name: Replication factor C large subunit
xref: UnificationXref4986
feature: FragmentFeature1035
cellular location: GO:0005654
comment: Reactome DB_ID: 3652751
display name: RFC1

Homologues of RFC1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q9GQW6
xref: UnificationXref4987
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652752

RF-C 38 kDa subunit
type: Protein
entity reference: Q8IIQ1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Replication factor C subunit 3
name: Replication factor C 38 kDa subunit
name: Q8IIQ1
name: A1 38 kDa subunit
name: RFC38
name: Activator 1 38 kDa subunit
xref: UnificationXref4981
feature: FragmentFeature1033
cellular location: GO:0005654
comment: Reactome DB_ID: 3652737
display name: RFC3

RF-C 38 kDa subunit
type: Protein
entity reference: Q9NFF6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q9NFF6
name: Replication factor C subunit 3
name: Replication factor C 38 kDa subunit
name: A1 38 kDa subunit
name: RFC38
name: Activator 1 38 kDa subunit
xref: UnificationXref4979
feature: FragmentFeature1032
cellular location: GO:0005654
comment: Reactome DB_ID: 3652735
display name: RFC3

Homologues of RFC3
type: Protein
data source: Provenance1
member physical entity: RF-C 38 kDa subunit
xref: UnificationXref4982
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652738

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q9GR09
data source: Provenance1
name: Replication factor C subunit 5
name: Activator 1 36 kDa subunit
name: A1 36 kDa subunit
name: RF-C 36 kDa subunit
name: RFC36
name: Activator 1 36 kDa subunit (Replication factor C 36 kDa subunit) (A1 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)
name: Q9GR09
name: Replication factor C 36 kDa subunit
xref: UnificationXref4976
feature: FragmentFeature1031
cellular location: GO:0005654
comment: Reactome DB_ID: 3652723
display name: RFC5

http://identifiers.org/pubmed/6300847
type: PublicationXref
id: 6300847
author: Filpula, D
author: Johnson, GG
author: Esty, AC
author: Jolly, DJ
author: Okayama, H
author: Bohlen, P
author: Berg, P
author: Hunkapillar, T
author: Friedmann, T
author: Shively, JE
db: Pubmed
title: Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase
source: Proc Natl Acad Sci U S A 80:477-81
year: 1983

UnificationXref628
type: UnificationXref
id: 3652840
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652840

UnificationXref629
type: UnificationXref
id: 3652841
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652841

UnificationXref626
type: UnificationXref
id: REACT_3817
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3817.2

UnificationXref627
type: UnificationXref
id: 3652839
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652839

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q26029
data source: Provenance1
name: ubiquitin (UBC 9)
name: UBC(609-684)
xref: UnificationXref4911
feature: FragmentFeature1012
cellular location: GO:0005829
comment: Reactome DB_ID: 3652521
display name: Q26029

UniProt:O96183
type: ProteinReference
xref: UnificationXref3862
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: ubiquitin (UBC 9)
name: UBC(609-684)
xref: UnificationXref4913
feature: FragmentFeature1014
cellular location: GO:0005829
comment: Reactome DB_ID: 3652523
display name: Q7KQK2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: ubiquitin (UBC 9)
name: UBC(609-684)
xref: UnificationXref4912
feature: FragmentFeature1013
cellular location: GO:0005829
comment: Reactome DB_ID: 3652522
display name: Q9U5M1

UniProt:O96184
type: ProteinReference
xref: UnificationXref1184
organism: BioSource1

http://identifiers.org/pubmed/12573255
type: PublicationXref
id: 12573255
author: Hegele, RA
author: Cao, H
author: Mok, A
db: Pubmed
title: Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase
source: Genomics 81:1-5
year: 2003

http://identifiers.org/pubmed/8246982
type: PublicationXref
id: 8246982
author: Wagner, BJ
author: Brewer, G
author: DeHaven, K
author: Schaefer, AW
author: Long, L
author: Crater, D
author: Ehrenman, K
author: Zhang, W
author: DeMaria, CT
db: Pubmed
title: Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1
source: Mol Cell Biol 13:7652-65
year: 1993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q26029
data source: Provenance1
name: ubiquitin (UBC 7)
name: UBC(457-532)
xref: UnificationXref4903
feature: FragmentFeature1006
cellular location: GO:0005829
comment: Reactome DB_ID: 3652513
display name: Q26029

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: ubiquitin (UBC 7)
name: UBC(457-532)
xref: UnificationXref4904
feature: FragmentFeature1007
cellular location: GO:0005829
comment: Reactome DB_ID: 3652514
display name: Q9U5M1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: ubiquitin (UBC 7)
name: UBC(457-532)
xref: UnificationXref4905
feature: FragmentFeature1008
cellular location: GO:0005829
comment: Reactome DB_ID: 3652515
display name: Q7KQK2

Homologues of UBC(533-608)
type: Protein
data source: Provenance1
member physical entity: ubiquitin (UBC 8)
xref: UnificationXref4910
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652520

ubiquitin (UBC 8)
type: Protein
entity reference: Q26029
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBC(533-608)
xref: UnificationXref4907
feature: FragmentFeature1009
cellular location: GO:0005829
comment: Reactome DB_ID: 3652517
display name: Q26029

ubiquitin (UBC 8)
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBC(533-608)
xref: UnificationXref4908
feature: FragmentFeature1010
cellular location: GO:0005829
comment: Reactome DB_ID: 3652518
display name: Q9U5M1

ubiquitin (UBC 8)
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBC(533-608)
xref: UnificationXref4909
feature: FragmentFeature1011
cellular location: GO:0005829
comment: Reactome DB_ID: 3652519
display name: Q7KQK2

Homologues of UBC(609-684)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4914
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652524

Homologues of MCM5
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4944
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652697

Q8I3J5
type: Protein
entity reference: Q8I3J5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P1-MCM3
name: DNA polymerase alpha holoenzyme-associated protein P1
name: RLF beta subunit
name: P102 protein
name: DNA replication licensing factor MCM3
name: Mcm3
xref: UnificationXref4939
feature: FragmentFeature1022
cellular location: GO:0005654
comment: Reactome DB_ID: 3652683
display name: MCM3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q9GR05
data source: Provenance1
name: Nuclear protein BM28
name: DNA replication licensing factor MCM2
name: Q9GR05
name: Mcm2
xref: UnificationXref4936
feature: FragmentFeature1021
cellular location: GO:0005654
comment: Reactome DB_ID: 3652711
display name: MCM2

Q8ILR7
type: Protein
entity reference: Q8ILR7
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Nuclear protein BM28
name: DNA replication licensing factor MCM2
name: Mcm2
xref: UnificationXref4934
feature: FragmentFeature1020
cellular location: GO:0005654
comment: Reactome DB_ID: 3652709
display name: MCM2

UniProt:O96176
type: ProteinReference
xref: UnificationXref1990
organism: BioSource1

http://identifiers.org/pubmed/8428933
type: PublicationXref
id: 8428933
author: Doroshow, JH
author: Esworthy, RS
author: Chu, FF
db: Pubmed
title: Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI
source: J Biol Chem 268:2571-6
year: 1993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8IC16
data source: Provenance1
name: Mcm7
name: P1.1-MCM3
name: DNA replication licensing factor MCM7
name: Q8IC16
name: CDC47 homolog
xref: UnificationXref4927
feature: FragmentFeature1017
cellular location: GO:0005654
comment: Reactome DB_ID: 3652705
display name: MCM7

Homologues of MCM4(1-863)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4932
cellular location: GO:0005654
comment: Reactome DB_ID: 3652690
comment: Converted from EntitySet in Reactome

Q8I615
type: Protein
entity reference: Q8I615
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Origin recognition complex subunit 1
name: Replication control protein 1
name: Orc1
xref: UnificationXref4916
feature: FragmentFeature1015
cellular location: GO:0005829
comment: Reactome DB_ID: 3652526
display name: ORC1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8IDF0
data source: Provenance1
name: DNA replication licensing factor MCM6
name: P105MCM
name: Q8IDF0
name: Mcm6
xref: UnificationXref4925
feature: FragmentFeature1016
cellular location: GO:0005654
comment: Reactome DB_ID: 3652701
display name: MCM6

Homologues of MCM2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q8ILR7
xref: UnificationXref4937
cellular location: GO:0005654
comment: Reactome DB_ID: 3652712
comment: Converted from EntitySet in Reactome

Apoptosis
type: Pathway
data source: Provenance1
pathway component: REACT 79211.9
pathway component: REACT 90988.9
evidence: Evidence442
xref: UnificationXref3737
xref: RelationshipXref461
xref: UnificationXref3736
pathway order: PathwayStep432
pathway order: PathwayStep430
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q9GR06
data source: Provenance1
name: MCM4(1-863)
name: P1-CDC21
name: DNA replication licensing factor MCM4
name: Q9GR06
name: CDC21 homolog
xref: UnificationXref4929
feature: FragmentFeature1018
cellular location: GO:0005654
comment: Reactome DB_ID: 3652687
display name: Mcm4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IEE5
data source: Provenance1
name: Q8IEE5
name: MCM4(1-863)
name: P1-CDC21
name: DNA replication licensing factor MCM4
name: CDC21 homolog
xref: UnificationXref4931
feature: FragmentFeature1019
cellular location: GO:0005654
comment: Reactome DB_ID: 3652689
display name: Mcm4

UnificationXref600
type: UnificationXref
id: REACT_9596
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9596.3

UnificationXref601
type: UnificationXref
id: 3652823
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652823

UnificationXref602
type: UnificationXref
id: 3654751
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654751

UnificationXref603
type: UnificationXref
id: REACT_157806
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157806.3

Glycogen synthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction57
evidence: Evidence146
xref: RelationshipXref103
xref: UnificationXref1357
xref: UnificationXref1356
pathway order: PathwayStep140
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:O96150
type: ProteinReference
xref: UnificationXref4582
organism: BioSource1

Homologues of UBC(457-532)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4906
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652516

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: ubiquitin (UBC 6)
name: UBC(381-456)
xref: UnificationXref4901
feature: FragmentFeature1005
cellular location: GO:0005829
comment: Reactome DB_ID: 3652511
display name: Q7KQK2

UniProt:O96153
type: ProteinReference
xref: UnificationXref904
organism: BioSource1

Resolution of AP sites via the single-nucleotide replacement pathway
type: Pathway
data source: Provenance1
pathway component: REACT 154362.3
evidence: Evidence668
xref: UnificationXref5234
xref: UnificationXref5235
pathway order: PathwayStep648
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/17560368
type: PublicationXref
id: 17560368
author: Peters, L
author: Meister, G
db: Pubmed
title: Argonaute proteins: mediators of RNA silencing
source: Mol Cell 26:611-23
year: 2007

Membrane Trafficking
type: Pathway
data source: Provenance1
pathway component: REACT 88478.9
pathway component: Translocation of GLUT4 to the Plasma Membrane
pathway component: REACT 77471.9
evidence: Evidence567
xref: RelationshipXref534
xref: UnificationXref4554
xref: UnificationXref4555
pathway order: PathwayStep552
pathway order: PathwayStep550
pathway order: PathwayStep518
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/1944596
type: PublicationXref
id: 1944596
author: Russell, DW
author: Andersson, S
author: Berman, DM
author: Jenkins, EP
db: Pubmed
title: Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism
source: Nature 354:159-61
year: 1991

http://identifiers.org/pubmed/22527994
type: PublicationXref
id: 22527994
author: Monaga, Madelyn
author: Campos, Derbis
db: Pubmed
title: Mucopolysaccharidosis type I: current knowledge on its pathophysiological mechanisms
source: Metab Brain Dis 27:121-9
year: 2012

http://identifiers.org/pubmed/12126930
type: PublicationXref
id: 12126930
author: Jakobs, C
author: Patel, A
author: Geraghty, MT
author: Thomas, GH
author: Schor, DS
author: Salomons, GS
author: Goh, DL
db: Pubmed
title: Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).
source: Mol Genet Metab 76:172-80
year: 2002

UnificationXref696
type: UnificationXref
id: 3655822
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655822

UnificationXref695
type: UnificationXref
id: 3655821
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655821

UnificationXref698
type: UnificationXref
id: 3655825
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655825

UnificationXref697
type: UnificationXref
id: 3655823
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655823

UnificationXref699
type: UnificationXref
id: REACT_108684
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108684.9

UnificationXref690
type: UnificationXref
id: REACT_80309
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80309.9

UnificationXref692
type: UnificationXref
id: 437093
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=437093

UnificationXref691
type: UnificationXref
id: GO:0008021
db: GENE ONTOLOGY

UnificationXref694
type: UnificationXref
id: GO:0030672
db: GENE ONTOLOGY

UnificationXref693
type: UnificationXref
id: REACT_21130
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21130.2

UniProt:O97248
type: ProteinReference
xref: UnificationXref1033
organism: BioSource1

UniProt:O97249
type: ProteinReference
xref: UnificationXref1077
organism: BioSource1

UniProt:O97250
type: ProteinReference
xref: UnificationXref1170
organism: BioSource1

http://identifiers.org/pubmed/12627223
type: PublicationXref
id: 12627223
author: Miyano, M
author: Irikura, Daisuke
author: Matsumura, H
author: Kumasaka, T
author: Kai, Y
author: Uodome, N
author: Urade, Y
author: Yamamoto, M
author: Inoue, T
author: Kinugasa, S
author: Okazaki, N
db: Pubmed
title: Mechanism of metal activation of human hematopoietic prostaglandin D synthase
source: Nat Struct Biol 10:291-6
year: 2003

long-chain fatty acid anion
type: SmallMoleculeReference
name: long-chain fatty acid anion [ChEBI:57560]
xref: UnificationXref1896

UniProt:O97247
type: ProteinReference
xref: UnificationXref4085
organism: BioSource1

UniProt:O97245
type: ProteinReference
xref: UnificationXref1809
organism: BioSource1

http://identifiers.org/pubmed/8431482
type: PublicationXref
id: 8431482
author: Ahmad, H
author: Singhal, S S
author: Awasthi, Y C
author: Saxena, M
db: Pubmed
title: Characterization of two novel subunits of the alpha-class glutathione S-transferases of human liver
source: Biochim. Biophys. Acta 1161:333-6
year: 1993

UniProt:O97240
type: ProteinReference
xref: UnificationXref5214
organism: BioSource1

http://identifiers.org/pubmed/18288277
type: PublicationXref
id: 18288277
author: Kersten, S
db: Pubmed
title: Peroxisome proliferator activated receptors and lipoprotein metabolism
source: PPAR Res 2008:132960
year: 2008

http://identifiers.org/pubmed/20110263
type: PublicationXref
id: 20110263
author: Kersten, S
author: de Groot, PJ
author: de Vries, SC
author: Muller, M
author: Degenhardt, T
author: Carlberg, C
author: Vaisanen, S
author: Heinaniemi, M
author: van der Meer, DL
db: Pubmed
title: Profiling of promoter occupancy by PPAR{alpha} in human hepatoma cells via ChIP-chip analysis
source: Nucleic Acids Res
year: 2010

UniProt:O97227
type: ProteinReference
xref: UnificationXref3262
organism: BioSource1

UnificationXref659
type: UnificationXref
id: REACT_19454
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19454.1

Gastrin-CREB signalling pathway via PKC and MAPK
type: Pathway
data source: Provenance1
pathway component: REACT 157443.3
evidence: Evidence841
xref: UnificationXref6057
xref: UnificationXref6056
pathway order: PathwayStep16
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Homologues of PRKG2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5574
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655621

KGP1A_HUMAN
type: Protein
entity reference: Q8MMZ4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: cGKIalpha
name: PRKG1-1
name: cGMP-dependent protein kinase 1, alpha isozyme
name: Q8MMZ4
name: PKG alpha
name: PRKG1 isoform 1
xref: UnificationXref5570
feature: FragmentFeature1078
cellular location: GO:0005829
comment: Reactome DB_ID: 3655617
display name: PRKG1

KGP1A_HUMAN
type: Protein
entity reference: UniProt:Q8I719
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: cGKIalpha
name: PRKG1-1
name: Q8I719
name: cGMP-dependent protein kinase 1, alpha isozyme
name: PKG alpha
name: PRKG1 isoform 1
xref: UnificationXref5568
feature: FragmentFeature1077
cellular location: GO:0005829
comment: Reactome DB_ID: 3655615
display name: PRKG1

Homologues of PRKG1-1
type: Protein
data source: Provenance1
member physical entity: KGP1A_HUMAN
xref: UnificationXref5571
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655618

UnificationXref660
type: UnificationXref
id: 30034
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30034

Homologues of PDE5A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5586
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655631

UnificationXref661
type: UnificationXref
id: REACT_3681
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3681.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8MMZ4
data source: Provenance1
name: Q8MMZ4
name: cGMP-dependent protein kinase 2
name: KGP2_HUMAN
xref: UnificationXref5573
feature: FragmentFeature1080
cellular location: GO:0005829
comment: Reactome DB_ID: 3655620
display name: PRKG2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8I719
data source: Provenance1
name: Q8I719
name: cGMP-dependent protein kinase 2
name: KGP2_HUMAN
xref: UnificationXref5572
feature: FragmentFeature1079
cellular location: GO:0005829
comment: Reactome DB_ID: 3655619
display name: PRKG2

UnificationXref664
type: UnificationXref
id: 3655727
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655727

UnificationXref665
type: UnificationXref
id: 3655728
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655728

UniProt:O97231
type: ProteinReference
xref: UnificationXref1147
organism: BioSource1

UnificationXref662
type: UnificationXref
id: 429148
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429148

UnificationXref663
type: UnificationXref
id: REACT_19915
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19915.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q5KTV3
data source: Provenance1
name: Valyl-tRNA synthetase 2
name: Q5KTV3
xref: UnificationXref5549
feature: FragmentFeature1076
cellular location: GO:0005759
comment: Reactome DB_ID: 3655373
display name: VARS2

UnificationXref668
type: UnificationXref
id: REACT_156910
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156910.3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IKL5
data source: Provenance1
name: Valyl-tRNA synthetase 2
name: Q8IKL5
xref: UnificationXref5548
feature: FragmentFeature1075
cellular location: GO:0005759
comment: Reactome DB_ID: 3655372
display name: VARS2

UnificationXref669
type: UnificationXref
id: 3657372
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657372

Homologues of VARS2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5550
cellular location: GO:0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655374

UnificationXref666
type: UnificationXref
id: 3655729
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655729

THF-polyglutamate
type: SmallMoleculeReference
name: Tetrahydrofolyl-[Glu](n)
name: Tetrahydrofolyl-[Glu](n) [ChEBI:9484]
name: Tetrahydrofolyl-[Glu](n+1)
xref: UnificationXref3149

UnificationXref667
type: UnificationXref
id: 3655731
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655731

UnificationXref649
type: UnificationXref
id: 3655718
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655718

UnificationXref648
type: UnificationXref
id: REACT_20174
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20174.1

UnificationXref650
type: UnificationXref
id: 3655719
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655719

UnificationXref651
type: UnificationXref
id: 3655720
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655720

UnificationXref652
type: UnificationXref
id: 3655721
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655721

UnificationXref653
type: UnificationXref
id: 3655723
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655723

http://identifiers.org/pubmed/15877282
type: PublicationXref
id: 15877282
author: Eshhar, S
author: Elpeleg, O
author: Saada, A
author: Miller, C
author: Bondi-Rubinstein, G
author: Pagnamenta, A
author: Rahman, S
author: Bitner-Glindzicz, M
author: Hershkovitz, E
db: Pubmed
title: Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion
source: Am J Hum Genet 76:1081-6
year: 2005

UnificationXref654
type: UnificationXref
id: REACT_153796
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153796.3

UnificationXref655
type: UnificationXref
id: CHEBI:17775
db: ChEBI

UnificationXref656
type: UnificationXref
id: 429056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429056

http://identifiers.org/pubmed/11909533
type: PublicationXref
id: 11909533
author: Ho, MW
author: Vogel, G
author: Shears, Stephen B
author: Chung, SK
author: Carew, MA
author: Kwon, YU
author: Riley, AM
author: Hua, L
author: Yang, X
author: Adelt, S
author: Potter, BV
author: Zhang, T
db: Pubmed
title: Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase
source: Curr Biol 12:477-82
year: 2002

UniProt:O97222
type: ProteinReference
xref: UnificationXref5880
organism: BioSource1

UnificationXref657
type: UnificationXref
id: REACT_19945
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19945.1

UniProt:O97223
type: ProteinReference
xref: UnificationXref3663
organism: BioSource1

UnificationXref658
type: UnificationXref
id: 429078
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429078

http://identifiers.org/pubmed/20192774
type: PublicationXref
id: 20192774
author: Leventis, PA
author: Grinstein, S
db: Pubmed
title: The distribution and function of phosphatidylserine in cellular membranes
source: Annu Rev Biophys 39:407-27
year: 2010

phospho-p-S2,S5-POLR2A
type: Protein
entity reference: C6F0A2
data source: Provenance1
xref: UnificationXref5315
feature: ModificationFeature70
feature: ModificationFeature59
feature: FragmentFeature1056
cellular location: GO:0005654
comment: Reactome DB_ID: 3654164

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IJP3
data source: Provenance1
name: Q8IJP3
name: Cysteinyl-tRNA synthetase
xref: UnificationXref5349
feature: FragmentFeature1057
cellular location: GO:0005829
comment: Reactome DB_ID: 3655305
display name: CARS

O96198
type: Protein
entity reference: UniProt:O96198
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Asparaginyl-tRNA synthetase 2
xref: UnificationXref5425
feature: FragmentFeature1065
cellular location: GO:0005759
comment: Reactome DB_ID: 3655401
display name: NARS2

UnificationXref682
type: UnificationXref
id: REACT_20925
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20925.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q5KTV3
data source: Provenance1
name: Q5KTV3
name: Valyl-tRNA synthetase
xref: UnificationXref5411
feature: FragmentFeature1064
cellular location: GO:0005829
comment: Reactome DB_ID: 3655342
display name: VARS

UnificationXref683
type: UnificationXref
id: GO:0010008
db: GENE ONTOLOGY

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IKL5
data source: Provenance1
name: Valyl-tRNA synthetase
name: Q8IKL5
xref: UnificationXref5409
feature: FragmentFeature1063
cellular location: GO:0005829
comment: Reactome DB_ID: 3655340
display name: VARS

UnificationXref680
type: UnificationXref
id: GO:0031904
db: GENE ONTOLOGY

Homologues of VARS
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref5412
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655343

UnificationXref681
type: UnificationXref
id: 435350
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=435350

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IL48
data source: Provenance1
name: Tyrosyl-tRNA synthetase
name: Q8IL48
xref: UnificationXref5398
feature: FragmentFeature1062
cellular location: GO:0005829
comment: Reactome DB_ID: 3655319
display name: YARS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IDW3
data source: Provenance1
name: WARS(2-471)
name: Tryptophanyl-tRNA synthetase
name: Q8IDW3
xref: UnificationXref5387
feature: FragmentFeature1061
cellular location: GO:0005829
comment: Reactome DB_ID: 3655312
display name: WARS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IIA4
data source: Provenance1
name: Q8IIA4
name: Threonyl-tRNA synthetase
xref: UnificationXref5376
feature: FragmentFeature1060
cellular location: GO:0005829
comment: Reactome DB_ID: 3655333
display name: TARS

Q8IBS3
type: Protein
entity reference: UniProt:Q8IBS3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Seryl-tRNA synthetase
name: SARS(2-514)
xref: UnificationXref5365
feature: FragmentFeature1059
cellular location: GO:0005829
comment: Reactome DB_ID: 3655326
display name: SARS

Q8ILP6
type: Protein
entity reference: Q8ILP6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Glycyl-tRNA synthetase
name: GARS(55-739)
xref: UnificationXref5357
feature: FragmentFeature1058
cellular location: GO:0005829
comment: Reactome DB_ID: 3655349
display name: GARS

http://identifiers.org/pubmed/8163052
type: PublicationXref
id: 8163052
author: Gomis, R
author: Malaisse, WJ
author: Sener, A
author: Fernandez-Alvarez, J
author: Conget, I
author: Rasschaert, J
db: Pubmed
title: Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients
source: Diabetologia 37:177-81
year: 1994

UnificationXref688
type: UnificationXref
id: 3655818
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655818

UnificationXref689
type: UnificationXref
id: 3655820
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655820

http://identifiers.org/pubmed/15080793
type: PublicationXref
id: 15080793
author: Wenk, MR
author: Uhlén, P
author: Lee, E
author: De Camilli, P
author: Ehrlich, BE
author: Degray, B
author: Johenning, FW
db: Pubmed
title: InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1
source: Biochem J 382:687-94
year: 2004

UnificationXref686
type: UnificationXref
id: Q8IBU1
db: UniProt

UnificationXref687
type: UnificationXref
id: 3655817
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655817

UnificationXref684
type: UnificationXref
id: Q9NFG4
db: UniProt

UnificationXref685
type: UnificationXref
id: 3655815
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655815

http://identifiers.org/pubmed/15105273
type: PublicationXref
id: 15105273
author: Westaway, SK
author: Johnson, MA
author: Parker, SM
author: Hayflick, SJ
author: Gitschier, J
author: Ching, KH
author: Kuo, YM
db: Pubmed
title: Mitochondrial localization of human PANK2 and hypotheses of secondary iron accumulation in pantothenate kinase-associated neurodegeneration
source: Ann N Y Acad Sci 1012:282-98
year: 2004

Cleavage of the damaged pyrimidine
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction339
pathway component: BiochemicalReaction341
pathway component: BiochemicalReaction342
pathway component: BiochemicalReaction340
evidence: Evidence658
xref: UnificationXref5209
xref: UnificationXref5208
xref: RelationshipXref565
pathway order: PathwayStep636
pathway order: PathwayStep637
pathway order: PathwayStep638
pathway order: PathwayStep635
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8IDD3
data source: Provenance1
name: Q8IDD3
name: Glutamyl-tRNA synthetase 2
xref: UnificationXref5434
feature: FragmentFeature1066
cellular location: GO:0005759
comment: Reactome DB_ID: 3655389
display name: EARS2

Q8IIA4
type: Protein
entity reference: Q8IIA4
data source: Provenance1
xref: UnificationXref5519
cellular location: GO:0005759
comment: Reactome DB_ID: 3655383

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I5P7
data source: Provenance1
name: Seryl-tRNA synthetase 2
name: Q8I5P7
xref: UnificationXref5509
feature: FragmentFeature1072
cellular location: GO:0005759
comment: Reactome DB_ID: 3655414
display name: SARS2

UnificationXref670
type: UnificationXref
id: REACT_159522
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159522.3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IIJ2
data source: Provenance1
name: Q8IIJ2
name: Tyrosyl-tRNA synthetase 2
xref: UnificationXref5538
feature: FragmentFeature1074
cellular location: GO:0005759
comment: Reactome DB_ID: 3655362
display name: YARS2

UnificationXref671
type: UnificationXref
id: 3657373
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657373

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I4R7
data source: Provenance1
name: Tryptophanyl-tRNA synthetase 2
name: Q8I4R7
xref: UnificationXref5528
feature: FragmentFeature1073
cellular location: GO:0005759
comment: Reactome DB_ID: 3655395
display name: WARS2

UnificationXref672
type: UnificationXref
id: REACT_115194
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115194.8

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IDJ8
data source: Provenance1
name: Lysyl-tRNA synthetase
name: Q8IDJ8
xref: UnificationXref5477
feature: FragmentFeature1069
cellular location: GO:0005759
comment: Reactome DB_ID: 3655407
display name: KARS

Q8IBB3
type: Protein
entity reference: UniProt:Q8IBB3
data source: Provenance1
xref: UnificationXref5465
cellular location: GO:0005759
comment: Reactome DB_ID: 3655380

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I2Q5
data source: Provenance1
name: Q8I2Q5
name: Prolyl-tRNA synthetase 2
xref: UnificationXref5499
feature: FragmentFeature1071
cellular location: GO:0005759
comment: Reactome DB_ID: 3655369
display name: PARS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8I716
data source: Provenance1
name: Methionyl-tRNA synthetase 2
name: Q8I716
xref: UnificationXref5490
feature: FragmentFeature1070
cellular location: GO:0005759
comment: Reactome DB_ID: 3655356
display name: MARS2

UnificationXref677
type: UnificationXref
id: 3655809
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655809

UnificationXref678
type: UnificationXref
id: 3655811
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655811

http://identifiers.org/pubmed/14990995
type: PublicationXref
id: 14990995
author: Yoshida, K
author: Inoue, I
db: Pubmed
title: Regulation of Geminin and Cdt1 expression by E2F transcription factors
source: Oncogene 23:3802-12
year: 2004

3-Methyl-2-oxopentanoate
type: SmallMoleculeReference
name: 2-Oxo-3-methylvalerate
name: 3-Methyl-2-oxopentanoate [ChEBI:28654]
xref: UnificationXref3243

Q8ILP6
type: Protein
entity reference: Q8ILP6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Glycyl-tRNA synthetase
xref: UnificationXref5452
feature: FragmentFeature1068
cellular location: GO:0005759
comment: Reactome DB_ID: 3655418
display name: GARS

UnificationXref679
type: UnificationXref
id: REACT_86040
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86040.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IE10
data source: Provenance1
name: Q8IE10
name: Glutaminyl-tRNA synthetase
xref: UnificationXref5445
feature: FragmentFeature1067
cellular location: GO:0005759
comment: Reactome DB_ID: 3655425
display name: QARS

UnificationXref673
type: UnificationXref
id: 435347
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=435347

UnificationXref674
type: UnificationXref
id: REACT_21053
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21053.2

UnificationXref675
type: UnificationXref
id: 351626
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=351626

UnificationXref676
type: UnificationXref
id: REACT_13894
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13894.1

PublicationXref600
type: PublicationXref
id: 1-893997-17-0
author: Chapkin, RS
author: Fan, YY
author: Ramos, KS
db: ISBN
title: Antiatherogenic Potential of gamma Linolenic Acid
source: gamma-linolenic acid (Book): 169
year: 2001

Glycogen breakdown (glycogenolysis)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction58
evidence: Evidence148
xref: UnificationXref1361
xref: UnificationXref1360
xref: RelationshipXref104
pathway order: PathwayStep142
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/6434529
type: PublicationXref
id: 6434529
author: Chuang, DT
author: Cox, RP
author: Markovitz, PJ
db: Pubmed
title: Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.
source: J Biol Chem 259:11643-6
year: 1984

http://identifiers.org/pubmed/19165215
type: PublicationXref
id: 19165215
author: Siomi, MC
author: Kim, VN
author: Han, J
db: Pubmed
title: Biogenesis of small RNAs in animals
source: Nat Rev Mol Cell Biol 10:126-39
year: 2009

RAF activation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction6
evidence: Evidence15
xref: UnificationXref202
xref: UnificationXref201
pathway order: PathwayStep14
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

PublicationXref611
type: PublicationXref
id: 978-0-444-53219-0
author: Smith, William L
author: Murphy, RC
db: ISBN
title: The eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase pathways
source: Biochemistry of Lipids, Lipoproteins and Membranes, 5th Edition (Book): 331-362
year: 2008

http://identifiers.org/pubmed/8946167
type: PublicationXref
id: 8946167
author: Blanch, L
author: Anson, D S
author: Hopwood, J J
author: Scott, H S
author: Guo, X H
author: Karageorgos, L E
author: Weber, B
db: Pubmed
title: Structure and sequence of the human sulphamidase gene
source: DNA Res. 3:269-71
year: 1996

SHC-related events
type: Pathway
data source: Provenance1
pathway component: REACT 157514.3
evidence: Evidence800
xref: UnificationXref5971
xref: UnificationXref5970
pathway order: PathwayStep773
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/8228618
type: PublicationXref
id: 8228618
author: Brown, EJ
author: Lefkowith, JB
author: Bromley, FA
author: Lennartz, MR
db: Pubmed
title: Immunoglobulin G-mediated phagocytosis activates a calcium-independent, phosphatidylethanolamine-specific phospholipase
source: J Leukoc Biol 54:389-98
year: 1993

http://identifiers.org/pubmed/10748114
type: PublicationXref
id: 10748114
author: You, Z
author: Kitagawa, M
author: Komamura-Kohno, Y
author: Ishimi, Y
author: Omori, A
db: Pubmed
title: Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2.
source: J Biol Chem 275:16235-41
year: 2000

http://identifiers.org/pubmed/15720390
type: PublicationXref
id: 15720390
author: Fabre, AL
author: Orlean, P
author: Taron, CH
db: Pubmed
title: Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly
source: FEBS J 272:1160-8
year: 2005

http://identifiers.org/pubmed/1104615
type: PublicationXref
id: 1104615
author: Adams, SL
author: Anderson, WF
author: Safer, B
author: Merrick, WC
db: Pubmed
title: Binding of MET-TRNAf and GTP to homogeneous initiation factor MP.
source: J Biol Chem 250:9076-82
year: 1976

http://identifiers.org/pubmed/9490415
type: PublicationXref
id: 9490415
author: Phillips, JH
author: Lanier, LL
author: Leong, C
author: Wu, J
author: Corliss, BC
db: Pubmed
title: Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
source: Nature 391:703-7
year: 1998

http://identifiers.org/pubmed/8755247
type: PublicationXref
id: 8755247
author: Migliaccio, E
author: Bonfini, L
author: Pelicci, PG
author: Pelicci, G
author: Lanfrancone, L
db: Pubmed
title: Not all Shc's roads lead to Ras
source: Trends Biochem Sci 21:257-61
year: 1996

UniProt:Q5KTV3
type: ProteinReference
xref: UnificationXref5410
organism: BioSource1

http://identifiers.org/pubmed/11742412
type: PublicationXref
id: 11742412
author: Saltiel, AR
author: Kahn, CR
db: Pubmed
title: Insulin signalling and the regulation of glucose and lipid metabolism
source: Nature 414:799-806
year: 2001

Acyl chain remodelling of PE
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction116
evidence: Evidence239
xref: RelationshipXref213
xref: UnificationXref1995
xref: UnificationXref1994
pathway order: PathwayStep233
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/18660845
type: PublicationXref
id: 18660845
author: Zhao, FQ
author: Keating, AF
db: Pubmed
title: Functional properties and genomics of glucose transporters
source: Curr Genomics 8:113-28
year: 2007

UniProt:O97282
type: ProteinReference
xref: UnificationXref4079
organism: BioSource1

http://identifiers.org/pubmed/12669019
type: PublicationXref
id: 12669019
author: Desjardins, M
db: Pubmed
title: ER-mediated phagocytosis: a new membrane for new functions
source: Nat Rev Immunol 3:280-91
year: 2003

PublicationXref636
type: PublicationXref
id: 9780849387326
author: Clarke, CF
author: Jonassen, T
db: ISBN
title: Genetic Analysis of Coenzyme Q Biosynthesis
source: Coenzyme Q: Molecular Mechanisms in Health and Disease (Book): 185-208
year: 2000

UniProt:O97295
type: ProteinReference
xref: UnificationXref1764
organism: BioSource1

http://identifiers.org/pubmed/6434534
type: PublicationXref
id: 6434534
author: Gracy, RW
author: Yuan, PM
author: Lu, HS
db: Pubmed
title: Primary structure of human triosephosphate isomerase
source: J Biol Chem 259:11958-68
year: 1984

http://identifiers.org/pubmed/15274629
type: PublicationXref
id: 15274629
author: Takeuchi, N
author: Heck, A
author: Spencer, AC
author: Watanabe, K
author: Spremulli, LL
db: Pubmed
title: Characterization of the human mitochondrial methionyl-tRNA synthetase
source: Biochemistry 43:9743-54
year: 2004

http://identifiers.org/pubmed/7354069
type: PublicationXref
id: 7354069
author: Anderson, PM
author: Desnick, RJ
db: Pubmed
title: Purification and properties of uroporphyrinogen I synthase from human erythrocytes. Identification of stable enzyme-substrate intermediates.
source: J Biol Chem 255:1993-9
year: 1980

UnificationXref2988
type: UnificationXref
id: REACT_152050
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152050.1

UnificationXref2987
type: UnificationXref
id: 2509835
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2509835

UnificationXref2989
type: UnificationXref
id: CHEBI:28806
db: ChEBI

UnificationXref2990
type: UnificationXref
id: 109330
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109330

UnificationXref2991
type: UnificationXref
id: REACT_2753
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2753.2

UnificationXref2992
type: UnificationXref
id: 3657026
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657026

UnificationXref2993
type: UnificationXref
id: REACT_159734
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159734.3

UnificationXref2994
type: UnificationXref
id: 3657027
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657027

UnificationXref2995
type: UnificationXref
id: CHEBI:10049
db: ChEBI

http://identifiers.org/pubmed/17331073
type: PublicationXref
id: 17331073
author: Wei, Y
author: Hornemann, T
author: von Eckardstein, A
db: Pubmed
title: Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?
source: Biochem J 405:157-64
year: 2007

UnificationXref2996
type: UnificationXref
id: 2509848
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2509848

UnificationXref2997
type: UnificationXref
id: REACT_150529
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150529.1

UnificationXref2999
type: UnificationXref
id: REACT_154602
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154602.3

UnificationXref2998
type: UnificationXref
id: 3657023
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657023

http://identifiers.org/pubmed/7354072
type: PublicationXref
id: 7354072
author: Bodlaender, P
author: Shemin, D
author: Bevan, DR
db: Pubmed
title: Mechanism of porphobilinogen synthase. Requirement of Zn2+ for enzyme activity.
source: J Biol Chem 255:2030-5
year: 1980

http://identifiers.org/pubmed/16183910
type: PublicationXref
id: 16183910
author: Wettschureck, N
author: Offermanns, S
db: Pubmed
title: Mammalian G proteins and their cell type specific functions
source: Physiol Rev 85:1159-204
year: 2005

G alpha (i) signalling events
type: Pathway
data source: Provenance1
pathway component: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
evidence: Evidence832
xref: UnificationXref6035
xref: UnificationXref6034
pathway order: PathwayStep803
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:O96196
type: ProteinReference
xref: UnificationXref4298
organism: BioSource1

UniProt:O96197
type: ProteinReference
xref: UnificationXref195
organism: BioSource1

UniProt:O96198
type: ProteinReference
xref: UnificationXref5424
organism: BioSource1

DAP12 signaling
type: Pathway
data source: Provenance1
pathway component: REACT 112227.8
pathway component: REACT 157443.3
evidence: Evidence787
xref: UnificationXref5906
xref: UnificationXref5907
pathway order: PathwayStep12
pathway order: PathwayStep16
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/20051984
type: PublicationXref
id: 20051984
author: Schimenti, JC
author: Handel, MA
db: Pubmed
title: Genetics of mammalian meiosis: regulation, dynamics and impact on fertility
source: Nat Rev Genet 11:124-36
year: 2010

http://identifiers.org/pubmed/14508490
type: PublicationXref
id: 14508490
author: Sacks, D
author: Goyette, G
author: Desjardins, M
author: Princiotta, MF
author: Brunet, S
author: Bertholet, S
author: Houde, M
author: Laplante, A
author: Thibault, P
author: Gagnon, E
db: Pubmed
title: Phagosomes are competent organelles for antigen cross-presentation
source: Nature 425:402-6
year: 2003

UnificationXref2943
type: UnificationXref
id: 110668
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110668

UnificationXref2944
type: UnificationXref
id: REACT_3368
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3368.2

UnificationXref2945
type: UnificationXref
id: 110720
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110720

UnificationXref2946
type: UnificationXref
id: REACT_3541
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3541.2

UnificationXref2947
type: UnificationXref
id: 110693
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110693

UnificationXref2948
type: UnificationXref
id: REACT_4471
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4471.2

UnificationXref2949
type: UnificationXref
id: 482803
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=482803

UnificationXref2951
type: UnificationXref
id: 113573
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113573

UnificationXref2950
type: UnificationXref
id: REACT_21808
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21808.1

UnificationXref2953
type: UnificationXref
id: 110577
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110577

UnificationXref2952
type: UnificationXref
id: REACT_4430
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4430.1

UnificationXref2956
type: UnificationXref
id: REACT_4564
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4564.1

UnificationXref2957
type: UnificationXref
id: 110653
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110653

UnificationXref2954
type: UnificationXref
id: REACT_4926
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4926.1

UnificationXref2955
type: UnificationXref
id: 110731
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110731

http://identifiers.org/pubmed/14508489
type: PublicationXref
id: 14508489
author: Kleijmeer, M
author: Saveanu, L
author: Amigorena, S
author: Van Endert, P
author: Davoust, J
author: Guermonprez, P
db: Pubmed
title: ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells
source: Nature 425:397-402
year: 2003

UnificationXref2958
type: UnificationXref
id: REACT_3618
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3618.1

UnificationXref2959
type: UnificationXref
id: 110681
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110681

UnificationXref2960
type: UnificationXref
id: REACT_3210
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3210.1

UnificationXref2964
type: UnificationXref
id: REACT_5560
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5560.1

UnificationXref2963
type: UnificationXref
id: 110719
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110719

UnificationXref2962
type: UnificationXref
id: REACT_3930
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3930.1

UnificationXref2961
type: UnificationXref
id: 110669
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110669

http://identifiers.org/pubmed/15758951
type: PublicationXref
id: 15758951
author: Wang, GX
author: Poo, MM
db: Pubmed
title: Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones
source: Nature 434:898-904
year: 2005

HDL-mediated lipid transport
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction85
evidence: Evidence186
xref: UnificationXref1611
xref: RelationshipXref152
xref: UnificationXref1612
pathway order: PathwayStep180
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2969
type: UnificationXref
id: 3656021
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656021

UnificationXref2965
type: UnificationXref
id: 110694
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110694

UnificationXref2966
type: UnificationXref
id: REACT_5573
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5573.1

UnificationXref2967
type: UnificationXref
id: 482807
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=482807

UnificationXref2968
type: UnificationXref
id: REACT_21642
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21642.1

UnificationXref2973
type: UnificationXref
id: 3656025
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656025

UnificationXref2972
type: UnificationXref
id: REACT_130233
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130233.5

UnificationXref2975
type: UnificationXref
id: 3657196
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657196

UnificationXref2974
type: UnificationXref
id: REACT_142013
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142013.5

UnificationXref2971
type: UnificationXref
id: 3656024
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656024

UnificationXref2970
type: UnificationXref
id: 3656022
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656022

UniProt:P14223
type: ProteinReference
xref: UnificationXref1268
organism: BioSource1

D-threo-Isocitric acid
type: SmallMoleculeReference
name: (1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylate [ChEBI:151]
name: Isocitric acid
name: (1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylate
xref: UnificationXref1828

UnificationXref2978
type: UnificationXref
id: 2509836
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2509836

UnificationXref2979
type: UnificationXref
id: REACT_151581
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151581.1

UnificationXref2976
type: UnificationXref
id: REACT_90295
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90295.9

UnificationXref2977
type: UnificationXref
id: CHEBI:16039
db: ChEBI

UnificationXref2986
type: UnificationXref
id: CHEBI:28807
db: ChEBI

UnificationXref2985
type: UnificationXref
id: 3657021
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657021

UnificationXref2984
type: UnificationXref
id: REACT_159672
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159672.3

UnificationXref2983
type: UnificationXref
id: 3657020
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657020

UnificationXref2982
type: UnificationXref
id: 3657018
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657018

UnificationXref2981
type: UnificationXref
id: 3657017
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657017

UnificationXref2980
type: UnificationXref
id: Q8IBP3
db: UniProt

http://identifiers.org/pubmed/17307970
type: PublicationXref
id: 17307970
author: Omori, K
author: Kotera, J
db: Pubmed
title: Overview of PDEs and their regulation
source: Circ Res 100:309-27
year: 2007

http://identifiers.org/pubmed/9045610
type: PublicationXref
id: 9045610
author: Weaver, PL
author: Chuang, RY
author: Chang, TH
author: Liu, Z
db: Pubmed
title: Requirement of the DEAD-Box protein ded1p for messenger RNA translation.
source: Science 275:1468-71
year: 1997

http://identifiers.org/pubmed/16510870
type: PublicationXref
id: 16510870
author: Hannon, GJ
author: Parker, R
author: Liu, J
author: Valencia-Sanchez, MA
db: Pubmed
title: Control of translation and mRNA degradation by miRNAs and siRNAs
source: Genes Dev 20:515-24
year: 2006

Synthesis of 12-eicosatetraenoic acid derivatives
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction139
pathway component: BiochemicalReaction138
evidence: Evidence277
xref: UnificationXref2251
xref: RelationshipXref252
xref: UnificationXref2250
pathway order: PathwayStep271
pathway order: PathwayStep270
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Insulin receptor signalling cascade
type: Pathway
data source: Provenance1
pathway component: SHC-related events
pathway component: IRS-related events
evidence: Evidence807
xref: UnificationXref5985
xref: UnificationXref5984
pathway order: PathwayStep774
pathway order: PathwayStep780
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/18772396
type: PublicationXref
id: 18772396
author: Zhang, X
author: Shinjo, SM
author: Rasheed, BA
author: Lin, JC
author: Carter, H
author: Jones, S
author: Keir, S
author: Parmigiani, G
author: Yan, H
author: McLendon, R
author: Olivi, A
author: Nikolsky, Y
author: Diaz Jr, LA
author: Tekleab, H
author: Vogelstein, B
author: Kinzler, KW
author: Velculescu, VE
author: Papadopoulos, N
author: Mankoo, P
author: Marie, SK
author: Parsons, DW
author: Busam, DA
author: Riggins, GJ
author: Bigner, DD
author: Karchin, R
author: Hartigan, J
author: Angenendt, P
author: Leary, RJ
author: Smith, DR
author: Strausberg, RL
author: Gallia, GL
author: Siu, IM
author: Nikolskaya, T
db: Pubmed
title: An integrated genomic analysis of human glioblastoma multiforme
source: Science 321:1807-12
year: 2008

http://identifiers.org/pubmed/17035995
type: PublicationXref
id: 17035995
author: De Camilli, P
author: Di Paolo, G
db: Pubmed
title: Phosphoinositides in cell regulation and membrane dynamics
source: Nature 443:651-7
year: 2006

http://identifiers.org/pubmed/15845384
type: PublicationXref
id: 15845384
author: Ohira, RH
author: Dipple, KM
author: McCabe, ER
author: Zhang, YH
db: Pubmed
title: Human and murine glycerol kinase: influence of exon 18 alternative splicing on function
source: Biochem Biophys Res Commun 331:239-46
year: 2005

IRS-related events
type: Pathway
data source: Provenance1
pathway component: REACT 157786.3
evidence: Evidence806
xref: UnificationXref5983
xref: UnificationXref5982
pathway order: PathwayStep779
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10899997
type: PublicationXref
id: 10899997
author: Bobik, E
author: Das, T
author: Mukerji, P
author: Thurmond, JM
author: Parker-Barnes, JM
author: Chaung, LT
author: Leonard, AE
author: Huang, YS
db: Pubmed
title: Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids
source: Proc Natl Acad Sci U S A 97:8284-9
year: 2000

http://identifiers.org/pubmed/10930435
type: PublicationXref
id: 10930435
author: Toole, BP
db: Pubmed
title: Hyaluronan is not just a goo!
source: J Clin Invest 106:335-6
year: 2000

http://identifiers.org/pubmed/16839620
type: PublicationXref
id: 16839620
author: Kushner, JP
author: Phillips, JD
author: Ajioka, RS
db: Pubmed
title: Biosynthesis of heme in mammals
source: Biochim Biophys Acta 1763:723-36
year: 2006

ChREBP activates metabolic gene expression
type: Pathway
data source: Provenance1
pathway component: TemplateReaction7
evidence: Evidence295
xref: RelationshipXref277
xref: UnificationXref2385
xref: UnificationXref2384
pathway order: PathwayStep289
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/21106529
type: PublicationXref
id: 21106529
author: Oakley, Aaron J
author: Casarotto, Marco G
author: Brock, Joseph
author: Board, PG
author: Zhou, Huina
db: Pubmed
title: Novel folding and stability defects cause a deficiency of human glutathione transferase omega 1
source: J. Biol. Chem. 286:4271-9
year: 2011

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9BHN0
data source: Provenance1
name: DNA polymerase alpha catalytic subunit
name: Q9BHN0
name: POLA1
xref: UnificationXref4730
feature: FragmentFeature923
cellular location: GO:0005654
comment: Reactome DB_ID: 3652404
display name: p180

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U0H1
data source: Provenance1
name: DNA polymerase alpha catalytic subunit
name: POLA1
name: Q9U0H1
xref: UnificationXref4728
feature: FragmentFeature922
cellular location: GO:0005654
comment: Reactome DB_ID: 3652402
display name: p180

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q53IG8
data source: Provenance1
name: DNA polymerase alpha catalytic subunit
name: POLA1
name: Q53IG8
xref: UnificationXref4726
feature: FragmentFeature921
cellular location: GO:0005654
comment: Reactome DB_ID: 3652400
display name: p180

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q5PZ25
data source: Provenance1
name: TYMS
name: TSase
name: Q5PZ25
name: Thymidylate synthase
xref: UnificationXref4737
feature: FragmentFeature928
cellular location: GO:0005654
comment: Reactome DB_ID: 3656050
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:C3S7P8
data source: Provenance1
name: TYMS
name: TSase
name: C3S7P8
name: Thymidylate synthase
xref: UnificationXref4736
feature: FragmentFeature927
cellular location: GO:0005654
comment: Reactome DB_ID: 3656049
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9GNC7
data source: Provenance1
name: TYMS
name: Q9GNC7
name: TSase
name: Thymidylate synthase
xref: UnificationXref4738
feature: FragmentFeature929
cellular location: GO:0005654
comment: Reactome DB_ID: 3656051
display name: TS

Homologues of TYMS
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q9GNB0
member physical entity: D9N170
member physical entity: D3KYV6
member physical entity: D0QXK2
xref: UnificationXref4763
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656076

http://identifiers.org/pubmed/18583706
type: PublicationXref
id: 18583706
author: Bakovic, M
author: Zhu, L
author: Johnson, C
db: Pubmed
title: Stimulation of the human CTP:phosphoethanolamine cytidylyltransferase gene by early growth response protein 1
source: J Lipid Res 49:2197-211
year: 2008

http://identifiers.org/pubmed/3356695
type: PublicationXref
id: 3356695
author: Panniers, R
author: Rowlands, AG
author: Henshaw, EC
db: Pubmed
title: The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2.
source: J Biol Chem 263:5526-33
year: 1988

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q53IH0
data source: Provenance1
name: DNA polymerase alpha catalytic subunit
name: Q53IH0
name: POLA1
xref: UnificationXref4732
feature: FragmentFeature924
cellular location: GO:0005654
comment: Reactome DB_ID: 3652406
display name: p180

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: A7UD81
data source: Provenance1
name: TYMS
name: A7UD81
name: TSase
name: Thymidylate synthase
xref: UnificationXref4735
feature: FragmentFeature926
cellular location: GO:0005654
comment: Reactome DB_ID: 3656048
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9GNB4
data source: Provenance1
name: TYMS
name: TSase
name: Q9GNB4
name: Thymidylate synthase
xref: UnificationXref4734
feature: FragmentFeature925
cellular location: GO:0005654
comment: Reactome DB_ID: 3656047
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: A3KCU6
data source: Provenance1
name: TYMS
name: TSase
name: A3KCU6
name: Thymidylate synthase
xref: UnificationXref4739
feature: FragmentFeature930
cellular location: GO:0005654
comment: Reactome DB_ID: 3656052
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:D0QXK4
data source: Provenance1
name: TYMS
name: TSase
name: D0QXK4
name: Thymidylate synthase
xref: UnificationXref4740
feature: FragmentFeature931
cellular location: GO:0005654
comment: Reactome DB_ID: 3656053
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: A7UD79
data source: Provenance1
name: TYMS
name: TSase
name: A7UD79
name: Thymidylate synthase
xref: UnificationXref4741
feature: FragmentFeature932
cellular location: GO:0005654
comment: Reactome DB_ID: 3656054
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q9GTX1
data source: Provenance1
name: TYMS
name: TSase
name: Q9GTX1
name: Thymidylate synthase
xref: UnificationXref4742
feature: FragmentFeature933
cellular location: GO:0005654
comment: Reactome DB_ID: 3656055
display name: TS

UnificationXref5012
type: UnificationXref
id: 3652780
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652780

UniProt:Q8MU52
type: ProteinReference
xref: UnificationXref2204
organism: BioSource1

UnificationXref5013
type: UnificationXref
id: REACT_34036
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34036.10

UnificationXref5010
type: UnificationXref
id: 3652777
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652777

UnificationXref5011
type: UnificationXref
id: 3652778
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652778

UnificationXref5016
type: UnificationXref
id: 3657172
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657172

UnificationXref5017
type: UnificationXref
id: REACT_107877
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107877.9

UnificationXref5014
type: UnificationXref
id: 3657173
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657173

UnificationXref5015
type: UnificationXref
id: REACT_30555
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30555.10

UnificationXref5018
type: UnificationXref
id: 3657171
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657171

UnificationXref5019
type: UnificationXref
id: REACT_76948
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_76948.9

http://identifiers.org/pubmed/12323090
type: PublicationXref
id: 12323090
author: Burdge, GC
author: Wootton, SA
db: Pubmed
title: Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women
source: Br J Nutr 88:411-20
year: 2002

http://identifiers.org/pubmed/2069720
type: PublicationXref
id: 2069720
author: Myöhänen, S
author: Kauppinen, L
author: Jänne, J
author: Wahlfors, J
author: Alhonen, L
db: Pubmed
title: Human spermidine synthase gene: structure and chromosomal localization
source: DNA Cell Biol 10:467-74
year: 1991

D0QXK2
type: Protein
entity reference: UniProt:D0QXK2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: TYMS
name: TSase
name: Thymidylate synthase
xref: UnificationXref4748
feature: FragmentFeature939
cellular location: GO:0005654
comment: Reactome DB_ID: 3656061
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q5PZ13
data source: Provenance1
name: TYMS
name: TSase
name: Q5PZ13
name: Thymidylate synthase
xref: UnificationXref4747
feature: FragmentFeature938
cellular location: GO:0005654
comment: Reactome DB_ID: 3656060
display name: TS

Q9GNB0
type: Protein
entity reference: Q9GNB0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: TYMS
name: TSase
name: Thymidylate synthase
xref: UnificationXref4746
feature: FragmentFeature937
cellular location: GO:0005654
comment: Reactome DB_ID: 3656059
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B3TLD5
data source: Provenance1
name: TYMS
name: TSase
name: B3TLD5
name: Thymidylate synthase
xref: UnificationXref4745
feature: FragmentFeature936
cellular location: GO:0005654
comment: Reactome DB_ID: 3656058
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I1R6
data source: Provenance1
name: TYMS
name: TSase
name: Q8I1R6
name: Thymidylate synthase
xref: UnificationXref4744
feature: FragmentFeature935
cellular location: GO:0005654
comment: Reactome DB_ID: 3656057
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q5PZ17
data source: Provenance1
name: TYMS
name: TSase
name: Q5PZ17
name: Thymidylate synthase
xref: UnificationXref4743
feature: FragmentFeature934
cellular location: GO:0005654
comment: Reactome DB_ID: 3656056
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q5PZ08
data source: Provenance1
name: TYMS
name: TSase
name: Q5PZ08
name: Thymidylate synthase
xref: UnificationXref4752
feature: FragmentFeature943
cellular location: GO:0005654
comment: Reactome DB_ID: 3656065
display name: TS

D9N170
type: Protein
entity reference: D9N170
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: TYMS
name: TSase
name: Thymidylate synthase
xref: UnificationXref4753
feature: FragmentFeature944
cellular location: GO:0005654
comment: Reactome DB_ID: 3656066
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:D0QXK7
data source: Provenance1
name: TYMS
name: TSase
name: D0QXK7
name: Thymidylate synthase
xref: UnificationXref4750
feature: FragmentFeature941
cellular location: GO:0005654
comment: Reactome DB_ID: 3656063
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D3W853
data source: Provenance1
name: TYMS
name: D3W853
name: TSase
name: Thymidylate synthase
xref: UnificationXref4751
feature: FragmentFeature942
cellular location: GO:0005654
comment: Reactome DB_ID: 3656064
display name: TS

UnificationXref5000
type: UnificationXref
id: REACT_31686
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31686.10

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:D0QXK5
data source: Provenance1
name: TYMS
name: TSase
name: D0QXK5
name: Thymidylate synthase
xref: UnificationXref4749
feature: FragmentFeature940
cellular location: GO:0005654
comment: Reactome DB_ID: 3656062
display name: TS

UnificationXref5001
type: UnificationXref
id: 3657170
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657170

UnificationXref5002
type: UnificationXref
id: REACT_31129
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31129.10

UnificationXref5003
type: UnificationXref
id: 68452
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=68452

UnificationXref5004
type: UnificationXref
id: REACT_4386
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4386.1

UnificationXref5005
type: UnificationXref
id: 69172
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69172

UnificationXref5006
type: UnificationXref
id: REACT_4394
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4394.1

UnificationXref5007
type: UnificationXref
id: Q8IES4
db: UniProt

Biological oxidations
type: Pathway
data source: Provenance1
pathway component: Phase II conjugation
pathway component: REACT 140397.5
evidence: Evidence419
xref: UnificationXref3592
xref: RelationshipXref444
xref: UnificationXref3591
pathway order: PathwayStep413
pathway order: PathwayStep408
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref5008
type: UnificationXref
id: 3652775
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652775

UnificationXref5009
type: UnificationXref
id: Q8WQK1
db: UniProt

http://identifiers.org/pubmed/12323085
type: PublicationXref
id: 12323085
author: Burdge, GC
author: Wootton, SA
author: Jones, AE
db: Pubmed
title: Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men*
source: Br J Nutr 88:355-63
year: 2002

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D3W856
data source: Provenance1
name: TYMS
name: TSase
name: D3W856
name: Thymidylate synthase
xref: UnificationXref4755
feature: FragmentFeature946
cellular location: GO:0005654
comment: Reactome DB_ID: 3656068
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9GNC9
data source: Provenance1
name: TYMS
name: TSase
name: Q9GNC9
name: Thymidylate synthase
xref: UnificationXref4754
feature: FragmentFeature945
cellular location: GO:0005654
comment: Reactome DB_ID: 3656067
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:E5F2V9
data source: Provenance1
name: TYMS
name: TSase
name: E5F2V9
name: Thymidylate synthase
xref: UnificationXref4757
feature: FragmentFeature948
cellular location: GO:0005654
comment: Reactome DB_ID: 3656070
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: D3W854
data source: Provenance1
name: TYMS
name: TSase
name: D3W854
name: Thymidylate synthase
xref: UnificationXref4756
feature: FragmentFeature947
cellular location: GO:0005654
comment: Reactome DB_ID: 3656069
display name: TS

Regulation of gene expression in beta cells
type: Pathway
data source: Provenance1
pathway component: TemplateReaction2
pathway component: TemplateReaction1
evidence: Evidence56
xref: UnificationXref392
xref: RelationshipXref29
xref: UnificationXref391
pathway order: PathwayStep53
pathway order: PathwayStep54
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:D0QXK6
data source: Provenance1
name: TYMS
name: TSase
name: D0QXK6
name: Thymidylate synthase
xref: UnificationXref4758
feature: FragmentFeature949
cellular location: GO:0005654
comment: Reactome DB_ID: 3656071
display name: TS

Gene Expression
type: Pathway
data source: Provenance1
pathway component: REACT 102312.9
pathway component: Regulatory RNA pathways
pathway component: REACT 93462.9
pathway component: REACT 105200.9
pathway component: REACT 79747.9
pathway component: REACT 137811.5
pathway component: REACT 103420.9
pathway component: REACT 132020.5
evidence: Evidence726
xref: UnificationXref5566
xref: RelationshipXref615
xref: UnificationXref5565
pathway order: PathwayStep559
pathway order: PathwayStep116
pathway order: PathwayStep476
pathway order: PathwayStep614
pathway order: PathwayStep702
pathway order: PathwayStep121
pathway order: PathwayStep108
pathway order: PathwayStep705
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

D3KYV6
type: Protein
entity reference: D3KYV6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: TYMS
name: TSase
name: Thymidylate synthase
xref: UnificationXref4759
feature: FragmentFeature950
cellular location: GO:0005654
comment: Reactome DB_ID: 3656072
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9GNB5
data source: Provenance1
name: TYMS
name: TSase
name: Q9GNB5
name: Thymidylate synthase
xref: UnificationXref4760
feature: FragmentFeature951
cellular location: GO:0005654
comment: Reactome DB_ID: 3656073
display name: TS

UniProt:Q8MTV7
type: ProteinReference
xref: UnificationXref3413
organism: BioSource1

Metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 77669.9
pathway component: REACT 115389.8
pathway component: REACT 104024.9
pathway component: Metabolism of lipids and lipoproteins
pathway component: Abacavir transport and metabolism
pathway component: REACT 145340.5
pathway component: REACT 154157.3
pathway component: REACT 96278.9
pathway component: REACT 91959.9
pathway component: REACT 154677.3
pathway component: REACT 108807.9
pathway component: REACT 100770.9
pathway component: Biological oxidations
evidence: Evidence427
xref: UnificationXref3627
xref: UnificationXref3628
xref: RelationshipXref454
pathway order: PathwayStep295
pathway order: PathwayStep414
pathway order: PathwayStep393
pathway order: PathwayStep405
pathway order: PathwayStep421
pathway order: PathwayStep345
pathway order: PathwayStep374
pathway order: PathwayStep291
pathway order: PathwayStep155
pathway order: PathwayStep179
pathway order: PathwayStep306
pathway order: PathwayStep285
pathway order: PathwayStep418
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:D0QXK8
data source: Provenance1
name: TYMS
name: TSase
name: D0QXK8
name: Thymidylate synthase
xref: UnificationXref4761
feature: FragmentFeature952
cellular location: GO:0005654
comment: Reactome DB_ID: 3656074
display name: TS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9GN27
data source: Provenance1
name: TYMS
name: TSase
name: Q9GN27
name: Thymidylate synthase
xref: UnificationXref4762
feature: FragmentFeature953
cellular location: GO:0005654
comment: Reactome DB_ID: 3656075
display name: TS

PRIM1
type: Protein
entity reference: Q7KQM1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DNA primase small subunit
name: Q7KQM1
name: DNA primase 49 kDa subunit
xref: UnificationXref4770
feature: FragmentFeature954
cellular location: GO:0005654
comment: Reactome DB_ID: 3652416
display name: p49

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IKK3
data source: Provenance1
name: Q8IKK3
name: DNA polymerase alpha 70 kDa subunit
name: DNA polymerase subunit B
name: POLA2
xref: UnificationXref4772
feature: FragmentFeature955
cellular location: GO:0005654
comment: Reactome DB_ID: 3652411
display name: p70

cGMP effects
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction379
pathway component: BiochemicalReaction380
evidence: Evidence729
xref: UnificationXref5612
xref: UnificationXref5613
pathway order: PathwayStep706
pathway order: PathwayStep707
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8ID50
data source: Provenance1
name: UBA52(1-76)
name: ubiquitin (UBA52)
xref: UnificationXref4834
feature: FragmentFeature959
cellular location: GO:0005654
comment: Reactome DB_ID: 3652442
display name: Q8ID50

phospho-p-S,T-ORC1
type: Protein
entity reference: Q8I615
data source: Provenance1
xref: UnificationXref4833
feature: ModificationFeature63
feature: FragmentFeature958
feature: ModificationFeature64
cellular location: GO:0005654
comment: Reactome DB_ID: 3652438

C6KTD8
type: Protein
entity reference: C6KTD8
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DNA polymerase II subunit A
name: DNA polymerase epsilon, catalytic subunit A
xref: UnificationXref4780
feature: FragmentFeature957
cellular location: GO:0005654
comment: Reactome DB_ID: 3652421
display name: POLE

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I579
data source: Provenance1
name: Q8I579
name: DNA polymerase II subunit B
name: DNA polymerase epsilon subunit B
xref: UnificationXref4778
feature: FragmentFeature956
cellular location: GO:0005654
comment: Reactome DB_ID: 3652425
display name: POLE2

UBC(1-76)
type: Protein
entity reference: Q26029
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ubiquitin (UBC 1)
name: Q26029
xref: UnificationXref4836
feature: FragmentFeature960
cellular location: GO:0005654
comment: Reactome DB_ID: 3652446
display name: UBC

UBC(1-76)
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ubiquitin (UBC 1)
name: Q9U5M1
xref: UnificationXref4838
feature: FragmentFeature961
cellular location: GO:0005654
comment: Reactome DB_ID: 3652448
display name: UBC

Homologues of UBC(1-76)
type: Protein
data source: Provenance1
member physical entity: UBC(1-76)
xref: UnificationXref4841
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652451

ubiquitin (UBC 2)
type: Protein
entity reference: Q26029
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBC(77-152)
xref: UnificationXref4842
feature: FragmentFeature963
cellular location: GO:0005654
comment: Reactome DB_ID: 3652452
display name: Q26029

ubiquitin (UBC 2)
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBC(77-152)
xref: UnificationXref4843
feature: FragmentFeature964
cellular location: GO:0005654
comment: Reactome DB_ID: 3652453
display name: Q9U5M1

UBC(1-76)
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ubiquitin (UBC 1)
name: Q7KQK2
xref: UnificationXref4840
feature: FragmentFeature962
cellular location: GO:0005654
comment: Reactome DB_ID: 3652450
display name: UBC

Homologues of UBC(77-152)
type: Protein
data source: Provenance1
member physical entity: ubiquitin (UBC 2)
xref: UnificationXref4845
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652455

http://identifiers.org/pubmed/17545517
type: PublicationXref
id: 17545517
author: Baines, AJ
author: Russell, GA
author: Gullick, WJ
author: Boyle, MM
author: Smart, LV
author: Morgan, BJ
author: Frost, TM
author: Hayes, NV
author: Blackburn, E
db: Pubmed
title: Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer
source: Clin Cancer Res 13:3147-55
year: 2007

UnificationXref5059
type: UnificationXref
id: REACT_77927
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77927.9

Magoh-Y14 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry235
component stoichiometry: Stoichiometry234
component: Protein443
component: Protein442
xref: UnificationXref1201
cellular location: GO:0005829
comment: Reactome DB_ID: 3656218

UnificationXref327
type: UnificationXref
id: 2466738
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2466738

UnificationXref5058
type: UnificationXref
id: 3657367
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657367

Core Exon Junction Complex (Core EJC) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry236
component stoichiometry: Stoichiometry237
component stoichiometry: Stoichiometry238
component: Magoh-Y14 complex (name copied from entity in Homo sapiens)
component: Protein444
component: PhysicalEntity37
xref: UnificationXref1210
cellular location: GO:0005829
comment: Reactome DB_ID: 3656219

UnificationXref328
type: UnificationXref
id: REACT_161305
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161305.1

Exon Junction:UPF2:UPF3 Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry233
component stoichiometry: Stoichiometry240
component stoichiometry: Stoichiometry239
component stoichiometry: Stoichiometry241
component: PhysicalEntity39
component: Core Exon Junction Complex (Core EJC) (name copied from entity in Homo sapiens)
component: PhysicalEntity36
component: PhysicalEntity38
xref: UnificationXref1213
cellular location: GO:0005829
comment: Reactome DB_ID: 3656223

UnificationXref325
type: UnificationXref
id: GO:0042622
db: GENE ONTOLOGY

UnificationXref326
type: UnificationXref
id: CHEBI:52592
db: ChEBI

UnificationXref323
type: UnificationXref
id: 3657540
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657540

UnificationXref324
type: UnificationXref
id: REACT_156004
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156004.3

UnificationXref321
type: UnificationXref
id: 3657539
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657539

UnificationXref322
type: UnificationXref
id: REACT_155907
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155907.3

UnificationXref5051
type: UnificationXref
id: 3654702
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654702

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q26029
data source: Provenance1
name: ubiquitin (UBC 5)
name: UBC(305-380)
xref: UnificationXref4854
feature: FragmentFeature972
cellular location: GO:0005654
comment: Reactome DB_ID: 3652464
display name: Q26029

UnificationXref5050
type: UnificationXref
id: 3654701
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654701

Homologues of UBC(305-380)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4857
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652467

ALDOB tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry266
component: Protein452
xref: UnificationXref1273
cellular location: GO:0005829
comment: Reactome DB_ID: 3652795

UnificationXref320
type: UnificationXref
id: REACT_157787
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157787.3

UnificationXref5053
type: UnificationXref
id: 3654703
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654703

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: ubiquitin (UBC 4)
name: UBC(229-304)
xref: UnificationXref4852
feature: FragmentFeature971
cellular location: GO:0005654
comment: Reactome DB_ID: 3652462
display name: Q7KQK2

glucose 6-phosphate isomerase dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry265
component: Protein451
xref: UnificationXref1256
cellular location: GO:0005829
comment: Reactome DB_ID: 3652859

UnificationXref5052
type: UnificationXref
id: REACT_95767
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95767.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: ubiquitin (UBC 4)
name: UBC(229-304)
xref: UnificationXref4851
feature: FragmentFeature970
cellular location: GO:0005654
comment: Reactome DB_ID: 3652461
display name: Q9U5M1

UPF1:eRF3 Complex on Translated mRNA (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry264
component stoichiometry: Stoichiometry263
component: Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction (name copied from entity in Homo sapiens)
component: Protein448
xref: UnificationXref1232
cellular location: GO:0005829
comment: Reactome DB_ID: 3656203

UnificationXref5055
type: UnificationXref
id: REACT_77906
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77906.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q26029
data source: Provenance1
name: ubiquitin (UBC 4)
name: UBC(229-304)
xref: UnificationXref4850
feature: FragmentFeature969
cellular location: GO:0005654
comment: Reactome DB_ID: 3652460
display name: Q26029

mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry257
component stoichiometry: Stoichiometry258
component stoichiometry: Stoichiometry256
component stoichiometry: Stoichiometry255
component: Cap Binding Complex (CBC) (name copied from entity in Homo sapiens)
component: PhysicalEntity43
component: Protein349
component: PhysicalEntity25
xref: UnificationXref1230
cellular location: GO:0005829
comment: Reactome DB_ID: 3656201

UnificationXref5054
type: UnificationXref
id: 3654704
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654704

Homologues of UBC(229-304)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4853
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652463

Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry259
component stoichiometry: Stoichiometry262
component stoichiometry: Stoichiometry260
component stoichiometry: Stoichiometry254
component stoichiometry: Stoichiometry261
component: GDP bound eRF3 (name copied from entity in Homo sapiens)
component: 80S ribosome (name copied from entity in Homo sapiens)
component: SmallMolecule76
component: mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction (name copied from entity in Homo sapiens)
component: Protein441
xref: UnificationXref1231
cellular location: GO:0005829
comment: Reactome DB_ID: 3656202

UnificationXref5057
type: UnificationXref
id: REACT_99801
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99801.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: UBC(153-228)
name: ubiquitin (UBC 3)
xref: UnificationXref4848
feature: FragmentFeature968
cellular location: GO:0005654
comment: Reactome DB_ID: 3652458
display name: Q7KQK2

SMG1:Phosphorylated UPF1:EJC:Translated mRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry251
component stoichiometry: Stoichiometry253
component stoichiometry: Stoichiometry252
component: Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction (name copied from entity in Homo sapiens)
component: SMG1:SMG8:SMG9 Complex (name copied from entity in Homo sapiens)
component: Protein449
xref: UnificationXref1223
cellular location: GO:0005829
comment: Reactome DB_ID: 3656242

UnificationXref5056
type: UnificationXref
id: 3657371
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657371

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: UBC(153-228)
name: ubiquitin (UBC 3)
xref: UnificationXref4847
feature: FragmentFeature967
cellular location: GO:0005654
comment: Reactome DB_ID: 3652457
display name: Q9U5M1

SMG1:SMG8:SMG9 Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry246
component stoichiometry: Stoichiometry244
component stoichiometry: Stoichiometry245
component: PhysicalEntity40
component: PhysicalEntity41
component: PhysicalEntity42
xref: UnificationXref1218
cellular location: GO:0005829
comment: Reactome DB_ID: 3656240

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q26029
data source: Provenance1
name: UBC(153-228)
name: ubiquitin (UBC 3)
xref: UnificationXref4846
feature: FragmentFeature966
cellular location: GO:0005654
comment: Reactome DB_ID: 3652456
display name: Q26029

ubiquitin (UBC 2)
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBC(77-152)
xref: UnificationXref4844
feature: FragmentFeature965
cellular location: GO:0005654
comment: Reactome DB_ID: 3652454
display name: Q7KQK2

Homologues of UBC(153-228)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4849
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652459

UnificationXref319
type: UnificationXref
id: 3657545
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657545

UnificationXref318
type: UnificationXref
id: REACT_159304
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159304.3

UnificationXref314
type: UnificationXref
id: REACT_154165
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154165.3

UnificationXref5049
type: UnificationXref
id: REACT_83118
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83118.9

UnificationXref315
type: UnificationXref
id: 3657550
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657550

UnificationXref5048
type: UnificationXref
id: 3654705
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654705

Homologues of UBC(381-456)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4861
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652471

HuR with Unknown Phosphorylation: mRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry131
component stoichiometry: Stoichiometry132
component: Protein345
component: PhysicalEntity24
xref: UnificationXref986
cellular location: GO:0005654
comment: Reactome DB_ID: 3655948

UnificationXref316
type: UnificationXref
id: REACT_146371
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146371.5

UnificationXref5047
type: UnificationXref
id: 3654700
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654700

HuR with phosphoserine221 and phosphoserine318:mRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry129
component stoichiometry: Stoichiometry130
component: PhysicalEntity23
component: Protein341
xref: UnificationXref977
cellular location: GO:0005654
comment: Reactome DB_ID: 3656038

UnificationXref317
type: UnificationXref
id: 3657542
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657542

UnificationXref310
type: UnificationXref
id: REACT_155857
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155857.3

UnificationXref311
type: UnificationXref
id: 3657548
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657548

UnificationXref312
type: UnificationXref
id: REACT_152597
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152597.3

UnificationXref313
type: UnificationXref
id: 3657543
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657543

UnificationXref5042
type: UnificationXref
id: 3654698
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654698

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: ubiquitin (UBC 7)
name: UBC(457-532)
xref: UnificationXref4863
feature: FragmentFeature979
cellular location: GO:0005654
comment: Reactome DB_ID: 3652473
display name: Q9U5M1

40S ribosomal complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry148
component stoichiometry: Stoichiometry154
component stoichiometry: Stoichiometry155
component stoichiometry: Stoichiometry159
component stoichiometry: Stoichiometry163
component stoichiometry: Stoichiometry146
component stoichiometry: Stoichiometry151
component stoichiometry: Stoichiometry145
component stoichiometry: Stoichiometry153
component stoichiometry: Stoichiometry141
component stoichiometry: Stoichiometry158
component stoichiometry: Stoichiometry150
component stoichiometry: Stoichiometry142
component stoichiometry: Stoichiometry173
component stoichiometry: Stoichiometry172
component stoichiometry: Stoichiometry168
component stoichiometry: Stoichiometry143
component stoichiometry: Stoichiometry161
component stoichiometry: Stoichiometry165
component stoichiometry: Stoichiometry147
component stoichiometry: Stoichiometry169
component stoichiometry: Stoichiometry162
component stoichiometry: Stoichiometry167
component stoichiometry: Stoichiometry152
component stoichiometry: Stoichiometry157
component stoichiometry: Stoichiometry144
component stoichiometry: Stoichiometry170
component stoichiometry: Stoichiometry171
component stoichiometry: Stoichiometry156
component stoichiometry: Stoichiometry164
component stoichiometry: Stoichiometry160
component stoichiometry: Stoichiometry166
component stoichiometry: Stoichiometry149
component: Protein369
component: PhysicalEntity29
component: Protein361
component: Protein366
component: Protein363
component: Protein374
component: Protein383
component: Protein354
component: Protein378
component: Protein357
component: Protein375
component: Protein370
component: Protein359
component: Protein362
component: Protein355
component: Protein353
component: Protein356
component: Protein385
component: Protein387
component: Protein367
component: Protein371
component: Protein379
component: Protein380
component: Protein360
component: Protein377
component: Protein364
component: PhysicalEntity28
component: Protein365
component: Protein386
component: Protein384
component: Protein358
component: Protein368
component: Protein376
xref: UnificationXref1079
cellular location: GO:0005829
comment: Reactome DB_ID: 3653283

http://identifiers.org/pubmed/19416660
type: PublicationXref
id: 19416660
author: Ren, M
author: Xu, Y
author: Malhotra, A
author: Schlame, M
db: Pubmed
title: Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species
source: Biochim Biophys Acta 1791:314-20
year: 2009

UnificationXref5041
type: UnificationXref
id: REACT_108323
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108323.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q26029
data source: Provenance1
name: ubiquitin (UBC 7)
name: UBC(457-532)
xref: UnificationXref4862
feature: FragmentFeature978
cellular location: GO:0005654
comment: Reactome DB_ID: 3652472
display name: Q26029

80S ribosome (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry227
component stoichiometry: Stoichiometry174
component: 40S ribosomal complex (name copied from entity in Homo sapiens)
component: 60S ribosomal complex (name copied from entity in Homo sapiens)
xref: UnificationXref1187
cellular location: GO:0005829
comment: Reactome DB_ID: 3653584

UnificationXref5040
type: UnificationXref
id: 3654697
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654697

Homologues of UBC(533-608)
type: Protein
data source: Provenance1
member physical entity: ubiquitin (UBC 8)
xref: UnificationXref4869
cellular location: GO:0005654
comment: Reactome DB_ID: 3652479
comment: Converted from EntitySet in Reactome

GDP bound eRF3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry229
component stoichiometry: Stoichiometry230
component: Protein440
component: SmallMolecule77
xref: UnificationXref1193
cellular location: GO:0005829
comment: Reactome DB_ID: 3654416

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: ubiquitin (UBC 7)
name: UBC(457-532)
xref: UnificationXref4864
feature: FragmentFeature980
cellular location: GO:0005654
comment: Reactome DB_ID: 3652474
display name: Q7KQK2

60S ribosomal complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry217
component stoichiometry: Stoichiometry191
component stoichiometry: Stoichiometry177
component stoichiometry: Stoichiometry208
component stoichiometry: Stoichiometry179
component stoichiometry: Stoichiometry221
component stoichiometry: Stoichiometry209
component stoichiometry: Stoichiometry203
component stoichiometry: Stoichiometry222
component stoichiometry: Stoichiometry181
component stoichiometry: Stoichiometry206
component stoichiometry: Stoichiometry193
component stoichiometry: Stoichiometry187
component stoichiometry: Stoichiometry214
component stoichiometry: Stoichiometry198
component stoichiometry: Stoichiometry195
component stoichiometry: Stoichiometry197
component stoichiometry: Stoichiometry220
component stoichiometry: Stoichiometry180
component stoichiometry: Stoichiometry210
component stoichiometry: Stoichiometry196
component stoichiometry: Stoichiometry186
component stoichiometry: Stoichiometry201
component stoichiometry: Stoichiometry182
component stoichiometry: Stoichiometry175
component stoichiometry: Stoichiometry225
component stoichiometry: Stoichiometry215
component stoichiometry: Stoichiometry212
component stoichiometry: Stoichiometry190
component stoichiometry: Stoichiometry183
component stoichiometry: Stoichiometry189
component stoichiometry: Stoichiometry211
component stoichiometry: Stoichiometry202
component stoichiometry: Stoichiometry194
component stoichiometry: Stoichiometry200
component stoichiometry: Stoichiometry213
component stoichiometry: Stoichiometry216
component stoichiometry: Stoichiometry184
component stoichiometry: Stoichiometry204
component stoichiometry: Stoichiometry226
component stoichiometry: Stoichiometry185
component stoichiometry: Stoichiometry207
component stoichiometry: Stoichiometry223
component stoichiometry: Stoichiometry218
component stoichiometry: Stoichiometry188
component stoichiometry: Stoichiometry224
component stoichiometry: Stoichiometry178
component stoichiometry: Stoichiometry192
component stoichiometry: Stoichiometry176
component stoichiometry: Stoichiometry199
component stoichiometry: Stoichiometry205
component stoichiometry: Stoichiometry219
component: Protein404
component: Protein398
component: Protein420
component: Protein421
component: Protein439
component: Protein410
component: Protein434
component: Protein430
component: Protein431
component: PhysicalEntity31
component: Protein418
component: Protein396
component: Protein428
component: Protein394
component: PhysicalEntity30
component: Protein403
component: Protein419
component: PhysicalEntity35
component: Protein411
component: Protein408
component: Protein416
component: Protein389
component: Protein432
component: PhysicalEntity32
component: Protein393
component: Protein397

UnificationXref5046
type: UnificationXref
id: REACT_99836
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99836.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: ubiquitin (UBC 6)
name: UBC(381-456)
xref: UnificationXref4859
feature: FragmentFeature976
cellular location: GO:0005654
comment: Reactome DB_ID: 3652469
display name: Q9U5M1

Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry242
component stoichiometry: Stoichiometry232
component stoichiometry: Stoichiometry140
component stoichiometry: Stoichiometry133
component stoichiometry: Stoichiometry228
component stoichiometry: Stoichiometry231
component: GDP bound eRF3 (name copied from entity in Homo sapiens)
component: 80S ribosome (name copied from entity in Homo sapiens)
component: SmallMolecule76
component: mRNA Complex with a Premature Termination Codon Preceding an Exon Junction (name copied from entity in Homo sapiens)
component: Exon Junction:UPF2:UPF3 Complex (name copied from entity in Homo sapiens)
component: Protein441
xref: UnificationXref1214
cellular location: GO:0005829
comment: Reactome DB_ID: 3656224

UnificationXref5045
type: UnificationXref
id: 3657366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657366

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q26029
data source: Provenance1
name: ubiquitin (UBC 6)
name: UBC(381-456)
xref: UnificationXref4858
feature: FragmentFeature975
cellular location: GO:0005654
comment: Reactome DB_ID: 3652468
display name: Q26029

SMG1:UPF1:EJC:Translated mRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry243
component stoichiometry: Stoichiometry248
component stoichiometry: Stoichiometry247
component: Protein448
component: Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction (name copied from entity in Homo sapiens)
component: SMG1:SMG8:SMG9 Complex (name copied from entity in Homo sapiens)
xref: UnificationXref1221
cellular location: GO:0005829
comment: Reactome DB_ID: 3656241

UnificationXref5044
type: UnificationXref
id: REACT_77925
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77925.9

Homologues of UBC(457-532)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4865
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652475

Cap Binding Complex (CBC) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry136
component stoichiometry: Stoichiometry137
component: PhysicalEntity26
component: Protein352
xref: UnificationXref1005
cellular location: GO:0005829
comment: Reactome DB_ID: 3656200

UnificationXref5043
type: UnificationXref
id: 3654699
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654699

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: ubiquitin (UBC 6)
name: UBC(381-456)
xref: UnificationXref4860
feature: FragmentFeature977
cellular location: GO:0005654
comment: Reactome DB_ID: 3652470
display name: Q7KQK2

mRNA Complex with a Premature Termination Codon Preceding an Exon Junction (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry134
component stoichiometry: Stoichiometry138
component stoichiometry: Stoichiometry135
component stoichiometry: Stoichiometry139
component: PhysicalEntity27
component: Cap Binding Complex (CBC) (name copied from entity in Homo sapiens)
component: Protein349
component: PhysicalEntity25
xref: UnificationXref1008
cellular location: GO:0005829
comment: Reactome DB_ID: 3656205

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: ubiquitin (UBC 5)
name: UBC(305-380)
xref: UnificationXref4855
feature: FragmentFeature973
cellular location: GO:0005654
comment: Reactome DB_ID: 3652465
display name: Q9U5M1

http://identifiers.org/pubmed/17597991
type: PublicationXref
id: 17597991
author: Ruggeri, ZM
db: Pubmed
title: Von Willebrand factor: looking back and looking forward
source: Thromb Haemost 98:55-62
year: 2007

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: ubiquitin (UBC 5)
name: UBC(305-380)
xref: UnificationXref4856
feature: FragmentFeature974
cellular location: GO:0005654
comment: Reactome DB_ID: 3652466
display name: Q7KQK2

UnificationXref308
type: UnificationXref
id: REACT_156349
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156349.3

UnificationXref307
type: UnificationXref
id: 3657541
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657541

UnificationXref309
type: UnificationXref
id: 3657544
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657544

G6PD tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry279
component stoichiometry: Stoichiometry280
component: SmallMolecule25
component: Protein466
xref: UnificationXref1387
cellular location: GO:0005829
comment: Reactome DB_ID: 3652808

UnificationXref301
type: UnificationXref
id: 3657547
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657547

UnificationXref302
type: UnificationXref
id: REACT_145050
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145050.5

UnificationXref300
type: UnificationXref
id: REACT_153330
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153330.3

UnificationXref5037
type: UnificationXref
id: 163085
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=163085

ubiquitin (UBC 8)
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBC(533-608)
xref: UnificationXref4868
feature: FragmentFeature983
cellular location: GO:0005654
comment: Reactome DB_ID: 3652478
display name: Q7KQK2

PLCB1:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry283
component stoichiometry: Stoichiometry284
component: SmallMolecule15
component: Protein473
xref: UnificationXref1432
cellular location: GO:0005829
comment: Reactome DB_ID: 3656840

UnificationXref305
type: UnificationXref
id: 3657549
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657549

UnificationXref5036
type: UnificationXref
id: CHEBI:15986
db: ChEBI

ubiquitin (UBC 8)
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBC(533-608)
xref: UnificationXref4867
feature: FragmentFeature982
cellular location: GO:0005654
comment: Reactome DB_ID: 3652477
display name: Q9U5M1

PLCbz
type: Complex
data source: Provenance1
member physical entity: PLCB1:Ca2+ (name copied from entity in Homo sapiens)
member physical entity: PLCB2:Ca2+ (name copied from entity in Homo sapiens)
member physical entity: PLCB4:Ca2+ (name copied from entity in Homo sapiens)
member physical entity: PLCB3:Ca2+ (name copied from entity in Homo sapiens)
member physical entity: PLCZ1:Ca2+ (name copied from entity in Homo sapiens)
xref: UnificationXref1441
cellular location: GO:0005829
comment: Reactome DB_ID: 3656846
comment: Converted from EntitySet in Reactome

UnificationXref306
type: UnificationXref
id: REACT_159876
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159876.3

UnificationXref5039
type: UnificationXref
id: 3654696
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654696

RPE dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry282
component: Protein471
xref: UnificationXref1410
cellular location: GO:0005829
comment: Reactome DB_ID: 3653023

UnificationXref303
type: UnificationXref
id: 3657546
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657546

UnificationXref5038
type: UnificationXref
id: REACT_8670
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_8670.2

PGD dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry281
component: Protein470
xref: UnificationXref1402
cellular location: GO:0005829
comment: Reactome DB_ID: 3653016

UnificationXref304
type: UnificationXref
id: REACT_131004
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131004.5

UnificationXref5033
type: UnificationXref
id: REACT_53493
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_53493.10

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: ubiquitin (UBC 9)
name: UBC(609-684)
xref: UnificationXref4872
feature: FragmentFeature986
cellular location: GO:0005654
comment: Reactome DB_ID: 3652482
display name: Q7KQK2

PLCZ1:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry291
component stoichiometry: Stoichiometry292
component: Protein477
component: SmallMolecule15
xref: UnificationXref1440
cellular location: GO:0005829
comment: Reactome DB_ID: 3656845

UnificationXref5032
type: UnificationXref
id: 3657156
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657156

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: ubiquitin (UBC 9)
name: UBC(609-684)
xref: UnificationXref4871
feature: FragmentFeature985
cellular location: GO:0005654
comment: Reactome DB_ID: 3652481
display name: Q9U5M1

PLCB4:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry289
component stoichiometry: Stoichiometry290
component: SmallMolecule15
component: Protein476
xref: UnificationXref1438
cellular location: GO:0005829
comment: Reactome DB_ID: 3656843

UnificationXref5035
type: UnificationXref
id: 3654695
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654695

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q26029
data source: Provenance1
name: ubiquitin (UBC 9)
name: UBC(609-684)
xref: UnificationXref4870
feature: FragmentFeature984
cellular location: GO:0005654
comment: Reactome DB_ID: 3652480
display name: Q26029

PLCB3:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry288
component stoichiometry: Stoichiometry287
component: Protein475
component: SmallMolecule15
xref: UnificationXref1436
cellular location: GO:0005829
comment: Reactome DB_ID: 3656842

UnificationXref5034
type: UnificationXref
id: 3654694
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654694

Homologues of UBC(609-684)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4873
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652483

PLCB2:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry285
component stoichiometry: Stoichiometry286
component: SmallMolecule15
component: Protein474
xref: UnificationXref1434
cellular location: GO:0005829
comment: Reactome DB_ID: 3656841

UBC(1-76)
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ubiquitin (UBC 1)
name: Q9U5M1
xref: UnificationXref4880
feature: FragmentFeature989
cellular location: GO:0005829
comment: Reactome DB_ID: 3652490
display name: UBC

UBC(1-76)
type: Protein
entity reference: Q26029
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ubiquitin (UBC 1)
name: Q26029
xref: UnificationXref4879
feature: FragmentFeature988
cellular location: GO:0005829
comment: Reactome DB_ID: 3652489
display name: UBC

UnificationXref5031
type: UnificationXref
id: REACT_32196
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32196.10

Homologues of UBC(1-76)
type: Protein
data source: Provenance1
member physical entity: UBC(1-76)
xref: UnificationXref4882
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652492

UnificationXref5030
type: UnificationXref
id: 3657161
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657161

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8ID50
data source: Provenance1
name: UBA52(1-76)
name: ubiquitin (UBA52)
name: Q8ID50
xref: UnificationXref4878
feature: FragmentFeature987
cellular location: GO:0005829
comment: Reactome DB_ID: 3652488
display name: UBA52

PLCdegh
type: Complex
data source: Provenance1
member physical entity: PLCE1:Ca2+ (name copied from entity in Homo sapiens)
member physical entity: PLCD3:Ca2+ (name copied from entity in Homo sapiens)
member physical entity: PLCH2:Ca2+ (name copied from entity in Homo sapiens)
member physical entity: PLCG1:Ca2+ (name copied from entity in Homo sapiens)
member physical entity: PLCD1:Ca2+ (name copied from entity in Homo sapiens)
member physical entity: PLCH1:Ca2+ (name copied from entity in Homo sapiens)
member physical entity: PLCG2:Ca2+ (name copied from entity in Homo sapiens)
xref: UnificationXref1460
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656884

http://identifiers.org/pubmed/14660560
type: PublicationXref
id: 14660560
author: Yu, Y
author: Arnold, E
author: Shen, N
author: Ding, Jianping
author: Xu, X
author: Jin, Y
author: Xu, F
author: Jia, J
author: Liu, Y
db: Pubmed
title: Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity
source: J Biol Chem 279:8378-88
year: 2004

ubiquitin (UBC 8)
type: Protein
entity reference: Q26029
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBC(533-608)
xref: UnificationXref4866
feature: FragmentFeature981
cellular location: GO:0005654
comment: Reactome DB_ID: 3652476
display name: Q26029

http://identifiers.org/pubmed/15381398
type: PublicationXref
id: 15381398
author: Jaffe, EK
db: Pubmed
title: The porphobilinogen synthase catalyzed reaction mechanism
source: Bioorg Chem 32:316-25
year: 2004

http://identifiers.org/pubmed/14660569
type: PublicationXref
id: 14660569
author: Chaussade, C
author: Mandel, JL
author: Liaubet, L
author: Payrastre, B
author: Pendaries, C
author: Tronchère, H
author: Laporte, J
author: Pirola, L
db: Pubmed
title: Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells
source: J Biol Chem 279:7304-12
year: 2004

http://identifiers.org/pubmed/7913615
type: PublicationXref
id: 7913615
author: Sheng, H
author: Warner, TD
author: Murad, F
author: Mitchell, JA
db: Pubmed
title: Effects of cyclic GMP on smooth muscle relaxation
source: Adv Pharmacol 26:171-94
year: 1994

UnificationXref5029
type: UnificationXref
id: REACT_101659
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101659.9

UnificationXref5028
type: UnificationXref
id: 3657160
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657160

UBC(1-76)
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ubiquitin (UBC 1)
name: Q7KQK2
xref: UnificationXref4881
feature: FragmentFeature990
cellular location: GO:0005829
comment: Reactome DB_ID: 3652491
display name: UBC

phosphoglycerate kinase 1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry269
component stoichiometry: Stoichiometry268
component: Protein458
component: SmallMolecule84
xref: UnificationXref1294
cellular location: GO:0005829
comment: Reactome DB_ID: 3652868

UnificationXref5027
type: UnificationXref
id: REACT_107026
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107026.9

triosephosphate isomerase dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry267
component: Protein455
xref: UnificationXref1281
cellular location: GO:0005829
comment: Reactome DB_ID: 3652852

UnificationXref5026
type: UnificationXref
id: 3657168
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657168

ubiquitin (UBC 2)
type: Protein
entity reference: Q26029
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBC(77-152)
xref: UnificationXref4883
feature: FragmentFeature991
cellular location: GO:0005829
comment: Reactome DB_ID: 3652493
display name: Q26029

phosphoglycerate mutase 1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry270
component: Protein459
xref: UnificationXref1302
cellular location: GO:0005829
comment: Reactome DB_ID: 3653037

UnificationXref5025
type: UnificationXref
id: REACT_88042
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88042.9

Homologues of UBC(77-152)
type: Protein
data source: Provenance1
member physical entity: ubiquitin (UBC 2)
xref: UnificationXref4886
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652496

phosphoglycerate mutase dimer
type: Complex
data source: Provenance1
member physical entity: phosphoglycerate mutase 2 dimer (name copied from entity in Homo sapiens)
member physical entity: phosphoglycerate mutase 1 dimer (name copied from entity in Homo sapiens)
xref: UnificationXref1305
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3653040

UnificationXref5024
type: UnificationXref
id: 3657167
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657167

ubiquitin (UBC 2)
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBC(77-152)
xref: UnificationXref4885
feature: FragmentFeature993
cellular location: GO:0005829
comment: Reactome DB_ID: 3652495
display name: Q7KQK2

enolase 1 dimer, (alpha) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry272
component stoichiometry: Stoichiometry273
component: Protein461
component: SmallMolecule84
xref: UnificationXref1316
cellular location: GO:0005829
comment: Reactome DB_ID: 3652878

UnificationXref5023
type: UnificationXref
id: REACT_78838
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78838.9

ubiquitin (UBC 2)
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UBC(77-152)
xref: UnificationXref4884
feature: FragmentFeature992
cellular location: GO:0005829
comment: Reactome DB_ID: 3652494
display name: Q9U5M1

phosphoglycerate mutase 2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry271
component: Protein460
xref: UnificationXref1304
cellular location: GO:0005829
comment: Reactome DB_ID: 3653039

UnificationXref5022
type: UnificationXref
id: 3657155
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657155

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q26029
data source: Provenance1
name: UBC(153-228)
name: ubiquitin (UBC 3)
xref: UnificationXref4887
feature: FragmentFeature994
cellular location: GO:0005829
comment: Reactome DB_ID: 3652497
display name: Q26029

PGM2:Mg++ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry275
component stoichiometry: Stoichiometry276
component: Protein465
component: SmallMolecule84
xref: UnificationXref1353
cellular location: GO:0005829
comment: Reactome DB_ID: 3652785

UnificationXref5021
type: UnificationXref
id: REACT_29294
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29294.10

Homologues of UBC(153-228)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4890
cellular location: GO:0005829
comment: Reactome DB_ID: 3652500
comment: Converted from EntitySet in Reactome

SLC25A11 homodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry274
component: Protein464
xref: UnificationXref1331
cellular location: GO:0005743
comment: Reactome DB_ID: 3654950

UnificationXref5020
type: UnificationXref
id: 3657154
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657154

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: UBC(153-228)
name: ubiquitin (UBC 3)
xref: UnificationXref4889
feature: FragmentFeature996
cellular location: GO:0005829
comment: Reactome DB_ID: 3652499
display name: Q7KQK2

G6PD dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry278
component stoichiometry: Stoichiometry277
component: SmallMolecule25
component: Protein466
xref: UnificationXref1386
cellular location: GO:0005829
comment: Reactome DB_ID: 3652807

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: UBC(153-228)
name: ubiquitin (UBC 3)
xref: UnificationXref4888
feature: FragmentFeature995
cellular location: GO:0005829
comment: Reactome DB_ID: 3652498
display name: Q9U5M1

G6PD dimer and tetramer
type: Complex
data source: Provenance1
member physical entity: G6PD dimer (name copied from entity in Homo sapiens)
member physical entity: G6PD tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref1388
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652809

Homologues of UBC(229-304)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4894
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652504

UnificationXref5094
type: UnificationXref
id: 110201
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110201

UnificationXref364
type: UnificationXref
id: 3657483
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657483

UnificationXref5095
type: UnificationXref
id: REACT_4400
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4400.1

UnificationXref363
type: UnificationXref
id: REACT_127924
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127924.5

UnificationXref5096
type: UnificationXref
id: Q8IKG6
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q26029
data source: Provenance1
name: ubiquitin (UBC 6)
name: UBC(381-456)
xref: UnificationXref4899
feature: FragmentFeature1003
cellular location: GO:0005829
comment: Reactome DB_ID: 3652509
display name: Q26029

UnificationXref362
type: UnificationXref
id: 3656171
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656171

UnificationXref5097
type: UnificationXref
id: 3654212
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654212

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: ubiquitin (UBC 6)
name: UBC(381-456)
xref: UnificationXref4900
feature: FragmentFeature1004
cellular location: GO:0005829
comment: Reactome DB_ID: 3652510
display name: Q9U5M1

UnificationXref361
type: UnificationXref
id: 3656169
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656169

UnificationXref5098
type: UnificationXref
id: 3654213
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654213

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: ubiquitin (UBC 5)
name: UBC(305-380)
xref: UnificationXref4897
feature: FragmentFeature1002
cellular location: GO:0005829
comment: Reactome DB_ID: 3652507
display name: Q7KQK2

UnificationXref360
type: UnificationXref
id: 3656168
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656168

LPIN3:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry327
component stoichiometry: Stoichiometry326
component: SmallMolecule185
component: Protein542
xref: UnificationXref1944
cellular location: GO:0005789
comment: Reactome DB_ID: 3656647

UnificationXref5099
type: UnificationXref
id: 3654214
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654214

Homologues of UBC(381-456)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4902
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652512

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q26029
data source: Provenance1
name: ubiquitin (UBC 5)
name: UBC(305-380)
xref: UnificationXref4895
feature: FragmentFeature1000
cellular location: GO:0005829
comment: Reactome DB_ID: 3652505
display name: Q26029

LPIN1:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry323
component stoichiometry: Stoichiometry322
component: SmallMolecule185
component: Protein523
xref: UnificationXref1941
cellular location: GO:0005789
comment: Reactome DB_ID: 3656644

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: ubiquitin (UBC 5)
name: UBC(305-380)
xref: UnificationXref4896
feature: FragmentFeature1001
cellular location: GO:0005829
comment: Reactome DB_ID: 3652506
display name: Q9U5M1

LPIN2:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry325
component stoichiometry: Stoichiometry324
component: SmallMolecule185
component: Protein524
xref: UnificationXref1942
cellular location: GO:0005789
comment: Reactome DB_ID: 3656645

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KQK2
data source: Provenance1
name: ubiquitin (UBC 4)
name: UBC(229-304)
xref: UnificationXref4893
feature: FragmentFeature999
cellular location: GO:0005829
comment: Reactome DB_ID: 3652503
display name: Q7KQK2

PCYT2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry321
component: Protein541
xref: UnificationXref1934
cellular location: GO:0005789
comment: Reactome DB_ID: 3656641

Homologues of UBC(305-380)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4898
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652508

LPIN
type: Complex
data source: Provenance1
member physical entity: LPIN2:Mg2+ (name copied from entity in Homo sapiens)
member physical entity: LPIN3:Mg2+ (name copied from entity in Homo sapiens)
member physical entity: LPIN1:Mg2+ (name copied from entity in Homo sapiens)
xref: UnificationXref1945
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656648

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q26029
data source: Provenance1
name: ubiquitin (UBC 4)
name: UBC(229-304)
xref: UnificationXref4891
feature: FragmentFeature997
cellular location: GO:0005829
comment: Reactome DB_ID: 3652501
display name: Q26029

holo-FDPS dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry319
component: FDPS:3Mg++ (name copied from entity in Homo sapiens)
xref: UnificationXref1870
cellular location: GO:0005829
comment: Reactome DB_ID: 3654837

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U5M1
data source: Provenance1
name: ubiquitin (UBC 4)
name: UBC(229-304)
xref: UnificationXref4892
feature: FragmentFeature998
cellular location: GO:0005829
comment: Reactome DB_ID: 3652502
display name: Q9U5M1

UnificationXref369
type: UnificationXref
id: REACT_160030
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160030.3

FDPS:3Mg++ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry317
component stoichiometry: Stoichiometry318
component: Protein534
component: SmallMolecule84
xref: UnificationXref1869
cellular location: GO:0005829
comment: Reactome DB_ID: 3654836

UnificationXref368
type: UnificationXref
id: 3657295
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657295

IDH1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry315
component: Protein532
xref: UnificationXref1842
cellular location: GO:0005782
comment: Reactome DB_ID: 3655511

UnificationXref367
type: UnificationXref
id: REACT_118260
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118260.7

IDH1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry316
component: Protein533
xref: UnificationXref1848
cellular location: GO:0005829
comment: Reactome DB_ID: 3655507

UnificationXref366
type: UnificationXref
id: 3657237
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657237

UnificationXref365
type: UnificationXref
id: REACT_162807
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_162807.2

ACAT1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry313
component: Protein528
xref: UnificationXref1788
cellular location: GO:0005759
comment: Reactome DB_ID: 3652970

Presynaptic phase of homologous DNA pairing and strand exchange
type: Pathway
data source: Provenance1
pathway component: REACT 100616.9
evidence: Evidence678
xref: UnificationXref5271
xref: UnificationXref5270
pathway order: PathwayStep658
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:Q9GSW0
type: ProteinReference
xref: UnificationXref4143
organism: BioSource1

UnificationXref5091
type: UnificationXref
id: REACT_79747
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79747.9

UnificationXref5090
type: UnificationXref
id: 3657330
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657330

UnificationXref5093
type: UnificationXref
id: REACT_89923
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89923.9

UnificationXref5092
type: UnificationXref
id: 3657331
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657331

UnificationXref5085
type: UnificationXref
id: REACT_136213
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136213.5

UnificationXref351
type: UnificationXref
id: CHEBI:18009
db: ChEBI

UnificationXref5086
type: UnificationXref
id: 3657332
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657332

UnificationXref350
type: UnificationXref
id: REACT_2991
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2991.3

UnificationXref5083
type: UnificationXref
id: 3654379
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654379

UnificationXref353
type: UnificationXref
id: REACT_4609
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4609.3

UnificationXref5084
type: UnificationXref
id: 3654380
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654380

UnificationXref352
type: UnificationXref
id: 29366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29366

UnificationXref5089
type: UnificationXref
id: REACT_146405
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146405.5

PLCH2:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry306
component stoichiometry: Stoichiometry305
component: Protein484
component: SmallMolecule100
xref: UnificationXref1459
cellular location: GO:0005886
comment: Reactome DB_ID: 3656883

ISYNA1:NAD+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry307
component stoichiometry: Stoichiometry308
component: Protein493
component: SmallMolecule129
xref: UnificationXref1588
cellular location: GO:0005829
comment: Reactome DB_ID: 3656853

UnificationXref5087
type: UnificationXref
id: REACT_126268
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126268.5

DGAT1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry309
component: Protein525
xref: UnificationXref1769
cellular location: GO:0005789
comment: Reactome DB_ID: 3654102

http://identifiers.org/pubmed/20435355
type: PublicationXref
id: 20435355
author: Palczewski, Krzysztof
db: Pubmed
title: Retinoids for treatment of retinal diseases
source: Trends Pharmacol. Sci. 31:284-95
year: 2010

UnificationXref5088
type: UnificationXref
id: 3657333
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657333

Btn-ACACA:2Mn2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry311
component stoichiometry: Stoichiometry310
component: SmallMolecule6
component: Protein495
xref: UnificationXref1774
cellular location: GO:0005829
comment: Reactome DB_ID: 3654020

PLCD3:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry297
component stoichiometry: Stoichiometry298
component: Protein480
component: SmallMolecule100
xref: UnificationXref1451
cellular location: GO:0005886
comment: Reactome DB_ID: 3656876

UnificationXref359
type: UnificationXref
id: 3656167
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656167

PLCG1:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry299
component stoichiometry: Stoichiometry300
component: Protein481
component: SmallMolecule100
xref: UnificationXref1453
cellular location: GO:0005886
comment: Reactome DB_ID: 3656877

UnificationXref358
type: UnificationXref
id: MOD:01632
db: MOD

PLCG2:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry302
component stoichiometry: Stoichiometry301
component: SmallMolecule100
component: Protein482
xref: UnificationXref1455
cellular location: GO:0005886
comment: Reactome DB_ID: 3656879

PLCH1:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry303
component stoichiometry: Stoichiometry304
component: Protein483
component: SmallMolecule100
xref: UnificationXref1457
cellular location: GO:0005886
comment: Reactome DB_ID: 3656881

UnificationXref355
type: UnificationXref
id: 880042
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=880042

http://identifiers.org/pubmed/20462400
type: PublicationXref
id: 20462400
author: Henley, Jeremy M
author: Wilkinson, Kevin A
db: Pubmed
title: Mechanisms, regulation and consequences of protein SUMOylation
source: Biochem. J. 428:133-45
year: 2010

UnificationXref354
type: UnificationXref
id: CHEBI:32796
db: ChEBI

PLCD1:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry294
component stoichiometry: Stoichiometry293
component: SmallMolecule100
component: Protein478
xref: UnificationXref1447
cellular location: GO:0005886
comment: Reactome DB_ID: 3656872

UnificationXref357
type: UnificationXref
id: Q8I6T2
db: UniProt

PLCE1:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry295
component stoichiometry: Stoichiometry296
component: Protein479
component: SmallMolecule100
xref: UnificationXref1449
cellular location: GO:0005886
comment: Reactome DB_ID: 3656874

UnificationXref356
type: UnificationXref
id: REACT_26229
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26229.2

UnificationXref5082
type: UnificationXref
id: 3654378
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654378

UnificationXref1997
type: UnificationXref
id: 1524071
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524071

UnificationXref5081
type: UnificationXref
id: 3654377
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654377

UnificationXref1998
type: UnificationXref
id: REACT_123890
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123890.1

UnificationXref5080
type: UnificationXref
id: 3654365
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654365

UnificationXref1999
type: UnificationXref
id: CHEBI:16436
db: ChEBI

UnificationXref5076
type: UnificationXref
id: REACT_135772
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135772.5

UnificationXref1992
type: UnificationXref
id: 3656585
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656585

UnificationXref5077
type: UnificationXref
id: 3657329
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657329

UnificationXref1991
type: UnificationXref
id: 3656582
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656582

UnificationXref5078
type: UnificationXref
id: REACT_77155
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77155.9

UnificationXref1990
type: UnificationXref
id: O96176
db: UniProt

UnificationXref5079
type: UnificationXref
id: Q8IJR8
db: UniProt

UnificationXref5072
type: UnificationXref
id: C6KSV4
db: UniProt

UnificationXref342
type: UnificationXref
id: REACT_162238
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_162238.2

UnificationXref1996
type: UnificationXref
id: CHEBI:36700
db: ChEBI

UnificationXref5073
type: UnificationXref
id: 3654374
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654374

UnificationXref341
type: UnificationXref
id: 3657559
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657559

UnificationXref1995
type: UnificationXref
id: REACT_130103
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130103.5

UnificationXref5074
type: UnificationXref
id: 3654375
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654375

UnificationXref340
type: UnificationXref
id: REACT_139213
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139213.5

UnificationXref1994
type: UnificationXref
id: 3657511
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657511

UnificationXref5075
type: UnificationXref
id: 3654376
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654376

UnificationXref1993
type: UnificationXref
id: REACT_141823
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141823.5

UnificationXref346
type: UnificationXref
id: 29406
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29406

UnificationXref345
type: UnificationXref
id: CHEBI:30915
db: ChEBI

UnificationXref344
type: UnificationXref
id: REACT_162532
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_162532.2

UnificationXref343
type: UnificationXref
id: 3657560
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657560

UnificationXref349
type: UnificationXref
id: 29364
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29364

UnificationXref348
type: UnificationXref
id: CHEBI:16474
db: ChEBI

http://identifiers.org/pubmed/19381358
type: PublicationXref
id: 19381358
author: Torti, FM
author: Shulaev, V
author: Mendes, P
author: Laubenbacher, R
author: Akman, S
author: Torti, SV
author: Hower, V
db: Pubmed
title: A general map of iron metabolism and tissue-specific subnetworks
source: Mol Biosyst 5:422-43
year: 2009

UnificationXref347
type: UnificationXref
id: REACT_5182
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5182.4

UnificationXref1988
type: UnificationXref
id: 1498738
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1498738

UnificationXref1989
type: UnificationXref
id: REACT_123106
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123106.1

UnificationXref5071
type: UnificationXref
id: 3654369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654369

UnificationXref1986
type: UnificationXref
id: REACT_126654
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126654.5

UnificationXref5070
type: UnificationXref
id: Q8IJA5
db: UniProt

UnificationXref1987
type: UnificationXref
id: CHEBI:29017
db: ChEBI

UnificationXref5067
type: UnificationXref
id: REACT_118290
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118290.7

UnificationXref5068
type: UnificationXref
id: 3657162
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657162

UnificationXref5065
type: UnificationXref
id: REACT_28158
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28158.10

UnificationXref1981
type: UnificationXref
id: 3656660
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656660

UnificationXref5066
type: UnificationXref
id: 3657157
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657157

UnificationXref1980
type: UnificationXref
id: 3656659
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656659

UnificationXref5063
type: UnificationXref
id: REACT_80940
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80940.9

UnificationXref1983
type: UnificationXref
id: 3656663
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656663

UnificationXref5064
type: UnificationXref
id: 3657370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657370

UnificationXref1982
type: UnificationXref
id: 3656661
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656661

UnificationXref5061
type: UnificationXref
id: REACT_77975
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77975.9

UnificationXref331
type: UnificationXref
id: REACT_160577
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160577.1

UnificationXref1985
type: UnificationXref
id: 3657514
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657514

UnificationXref5062
type: UnificationXref
id: 3657369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657369

UnificationXref330
type: UnificationXref
id: 432659
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=432659

UnificationXref1984
type: UnificationXref
id: REACT_135766
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135766.5

UnificationXref333
type: UnificationXref
id: 2466848
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2466848

Metabolism of folate and pterines
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction204
pathway component: BiochemicalReaction202
pathway component: BiochemicalReaction203
evidence: Evidence375
xref: UnificationXref3178
xref: RelationshipXref392
xref: UnificationXref3179
pathway order: PathwayStep367
pathway order: PathwayStep369
pathway order: PathwayStep368
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref332
type: UnificationXref
id: CHEBI:71980
db: ChEBI

UnificationXref335
type: UnificationXref
id: Q8IHS7
db: UniProt

UnificationXref334
type: UnificationXref
id: REACT_160703
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160703.1

UnificationXref337
type: UnificationXref
id: 3657013
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657013

UnificationXref336
type: UnificationXref
id: 3657011
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657011

UnificationXref5069
type: UnificationXref
id: REACT_99459
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99459.9

UnificationXref339
type: UnificationXref
id: 3657558
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657558

UnificationXref338
type: UnificationXref
id: REACT_163035
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_163035.2

UnificationXref329
type: UnificationXref
id: CHEBI:16337
db: ChEBI

UnificationXref5060
type: UnificationXref
id: 3657368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657368

UnificationXref1975
type: UnificationXref
id: 3656654
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656654

http://identifiers.org/pubmed/10648173
type: PublicationXref
id: 10648173
author: Menear, K
author: Baldock, D
author: Graff, P
author: Jones, CE
author: Akhlaq, M
author: Graham, B
db: Pubmed
title: Purification and characterization of human Syk produced using a baculovirus expression system
source: Protein Expr Purif 18:86-94
year: 2000

UnificationXref1976
type: UnificationXref
id: Q9GPP8
db: UniProt

http://identifiers.org/pubmed/19261456
type: PublicationXref
id: 19261456
author: Procko, E
author: Gaudet, R
db: Pubmed
title: Antigen processing and presentation: TAPping into ABC transporters
source: Curr Opin Immunol 21:84-91
year: 2009

http://identifiers.org/pubmed/14091597
type: PublicationXref
id: 14091597
author: Lamy, M
author: MARIE, J
author: MAROTEAUX, P
author: Leveque, B
db: Pubmed
title: [A NEW DYSOSTOSIS WITH URINARY ELIMINATION OF CHONDROITIN SULFATE B]
source: Presse Med 71:1849-52
year: 1963

UnificationXref1977
type: UnificationXref
id: 3656656
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656656

UnificationXref1978
type: UnificationXref
id: 3656657
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656657

UnificationXref1979
type: UnificationXref
id: 3656658
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656658

UnificationXref398
type: UnificationXref
id: 3652831
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652831

UnificationXref399
type: UnificationXref
id: 3656324
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656324

UnificationXref392
type: UnificationXref
id: REACT_97545
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97545.9

UnificationXref393
type: UnificationXref
id: 3657407
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657407

UnificationXref390
type: UnificationXref
id: REACT_158172
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158172.3

UnificationXref391
type: UnificationXref
id: 3657406
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657406

UnificationXref396
type: UnificationXref
id: 3652829
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652829

UnificationXref397
type: UnificationXref
id: 3652830
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652830

UnificationXref394
type: UnificationXref
id: REACT_80121
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80121.9

UnificationXref395
type: UnificationXref
id: 3652828
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652828

http://identifiers.org/pubmed/47244
type: PublicationXref
id: 47244
author: Cash, JD
author: Pepper, DS
author: Moore, S
db: Pubmed
title: The isolation and characterisation of a platelet-specific beta-globulin (beta-thromboglobulin) and the detection of antiurokinase and antiplasmin released from thrombin-aggregated washed human platelets
source: Biochim Biophys Acta 379:360-9
year: 1975

Inhibition of replication initiation of damaged DNA by RB1/E2F1
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction303
evidence: Evidence582
xref: UnificationXref4803
xref: UnificationXref4802
pathway order: PathwayStep565
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/21479626
type: PublicationXref
id: 21479626
author: Sass, JO
db: Pubmed
title: Inborn errors of ketogenesis and ketone body utilization
source: J Inherit Metab Dis
year: 2011

Transmembrane transport of small molecules
type: Pathway
data source: Provenance1
pathway component: Iron uptake and transport
pathway component: REACT 79086.9
pathway component: REACT 114890.8
pathway component: Ion channel transport
evidence: Evidence108
xref: UnificationXref825
xref: UnificationXref826
xref: RelationshipXref36
pathway order: PathwayStep105
pathway order: PathwayStep98
pathway order: PathwayStep63
pathway order: PathwayStep101
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref378
type: UnificationXref
id: 3657296
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657296

UnificationXref379
type: UnificationXref
id: REACT_112315
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112315.8

UnificationXref376
type: UnificationXref
id: 3657477
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657477

UnificationXref377
type: UnificationXref
id: REACT_115225
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115225.8

UnificationXref374
type: UnificationXref
id: 3657476
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657476

UnificationXref375
type: UnificationXref
id: REACT_112229
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112229.8

UnificationXref372
type: UnificationXref
id: 3656126
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656126

UnificationXref373
type: UnificationXref
id: REACT_114663
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114663.8

UnificationXref370
type: UnificationXref
id: 3656123
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656123

UnificationXref371
type: UnificationXref
id: 3656124
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656124

Activation of Chaperone Genes by XBP1(S)
type: Pathway
data source: Provenance1
pathway component: Expression of DNAJB11
pathway component: Expression of KDELR3
pathway component: Expression of SRPR (SRP Receptor subunit alpha)
pathway component: Expression of DDX11
pathway component: Expression of SRPRB (SRP Receptor subunit beta)
pathway component: Expression of TSPYL2
pathway component: Expression of KLHDC3
pathway component: Expression of Sec31A
pathway component: Expression of HYOU1
pathway component: Expression of GSK3A
pathway component: Expression of SYVN1 (HRD1)
pathway component: Expression of GFPT1
pathway component: Expression of ATP6VOD1
evidence: Evidence554
xref: UnificationXref4476
xref: UnificationXref4475
pathway order: PathwayStep534
pathway order: PathwayStep540
pathway order: PathwayStep532
pathway order: PathwayStep528
pathway order: PathwayStep539
pathway order: PathwayStep533
pathway order: PathwayStep537
pathway order: PathwayStep529
pathway order: PathwayStep531
pathway order: PathwayStep536
pathway order: PathwayStep530
pathway order: PathwayStep535
pathway order: PathwayStep538
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/2531289
type: PublicationXref
id: 2531289
author: Sugimura, A
author: Hagiya, M
author: Shimizu, S
author: Shimonishi, M
author: Seki, T
author: Tashiro, K
author: Nishizawa, T
author: Nakamura, T
db: Pubmed
title: Molecular cloning and expression of human hepatocyte growth factor
source: Nature 342:440-3
year: 1989

http://identifiers.org/pubmed/16816140
type: PublicationXref
id: 16816140
author: Westlake, C
author: Cole, SP
author: Deeley, RG
db: Pubmed
title: Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
source: Physiol Rev 86:849-99
year: 2006

UnificationXref387
type: UnificationXref
id: 3652821
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652821

UnificationXref388
type: UnificationXref
id: 3652822
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652822

UnificationXref389
type: UnificationXref
id: 3655222
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655222

http://identifiers.org/pubmed/13679574
type: PublicationXref
id: 13679574
author: Bouvier, M
author: Rousseau, G
author: Angers, S
author: Charest, PG
author: Kohout, T
author: Azzi, M
author: Piñeyro, G
db: Pubmed
title: Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
source: Proc Natl Acad Sci U S A 100:11406-11
year: 2003

UnificationXref383
type: UnificationXref
id: REACT_94998
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94998.9

UnificationXref384
type: UnificationXref
id: Q7KWJ5
db: UniProt

http://identifiers.org/pubmed/11123943
type: PublicationXref
id: 11123943
author: Klee, C B
author: Yang, S A
db: Pubmed
title: Low affinity Ca2+-binding sites of calcineurin B mediate conformational changes in calcineurin A
source: Biochemistry 39:16147-54
year: 2000

UnificationXref385
type: UnificationXref
id: 3652820
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652820

UnificationXref386
type: UnificationXref
id: O97467
db: UniProt

http://identifiers.org/pubmed/12136087
type: PublicationXref
id: 12136087
author: Schneider, RJ
author: Laroia, G
db: Pubmed
title: Alternate exon insertion controls selective ubiquitination and degradation of different AUF1 protein isoforms
source: Nucleic Acids Res 30:3052-8
year: 2002

UnificationXref380
type: UnificationXref
id: Q02155
db: UniProt

UnificationXref381
type: UnificationXref
id: 3652838
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652838

UnificationXref382
type: UnificationXref
id: 3655221
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655221

http://identifiers.org/pubmed/14988808
type: PublicationXref
id: 14988808
author: Jakobs, C
author: Huck, JH
author: Verhoeven, NM
author: van der Knaap, MS
author: Struys, EA
author: Salomons, GS
db: Pubmed
title: Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathy
source: Am J Hum Genet 74:745-51
year: 2004

http://identifiers.org/pubmed/1550217
type: PublicationXref
id: 1550217
author: Gould, GW
author: Bell, GI
author: Burant, CF
author: Davidson, NO
author: Ifkovits, CA
author: Hausman, AM
author: Buse, JB
db: Pubmed
title: Human intestinal glucose transporter expression and localization of GLUT5
source: Am J Physiol 262:C795-800
year: 1992

ChEBI:31488 dihydroceramides
type: SmallMoleculeReference
name: dihydroceramides
xref: UnificationXref2277

UniProt:Q9NDT2
type: ProteinReference
xref: UnificationXref3992
organism: BioSource1

http://identifiers.org/pubmed/14559994
type: PublicationXref
id: 14559994
author: Iwakoshi, NN
author: Lee, AH
author: Glimcher, LH
db: Pubmed
title: XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
source: Mol Cell Biol 23:7448-59
year: 2003

PublicationXref944
type: PublicationXref
author: KATZ, LC
author: McNamara, JO
author: Purves, D
author: Williams, JM
author: Fitzpatrick, D
author: LaMantia, AS
author: Augustine, DJ
title: Neuroscience 2nd Edition
source: Sinauer Associates, Inc., P.O. Box 407 23 Plumtree Road, Sunderland, MA 01375 U.S.A.
year: 2001

PublicationXref945
type: PublicationXref
author: Hershey, JW
author: Merrick, WC
title: Pathway and mechanism of initiation of protein synthesis.
source: Translational Control of Gene Expression. (Sonenberg, Hershey and Mathews, eds.)33-88
year: 2000

PublicationXref949
type: PublicationXref
author: Dever, TE
author: Nag, MK
author: Wu, S
author: Hershey, JW
author: MacMillan, S
author: Merrick, WC
author: Roy, AL
author: Kinzy, TG
author: Hileman, RE
author: Gupta, S
title: New insights into an old problem: ternary complex (Met-tRNAf.eIF.GTP) formation in animal cells.
source: Post-transcriptional control of gene expression. J.E. McCarty and M.F.Tuite (eds).521-526
year: 1990

http://identifiers.org/pubmed/13538944
type: PublicationXref
id: 13538944
author: Tsuboi, KK
author: Hudson, PB
author: Estrada, J
db: Pubmed
title: Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties.
source: J Biol Chem 231:19-29
year: 1958

MTABC3 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry43
component: Protein148
xref: UnificationXref472
cellular location: GO:0005741
comment: Reactome DB_ID: 3656416

GLUT4 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry42
component: Protein111
xref: UnificationXref398
cellular location: GO:0005886
comment: Reactome DB_ID: 3652831

GLUT2 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry46
component: Protein108
xref: UnificationXref601
cellular location: GO:0005886
comment: Reactome DB_ID: 3652823

ATP6V0C hexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry27
component: Protein31
xref: UnificationXref67
cellular location: phagocytic vesicle membrane
comment: Reactome DB_ID: 3656342

Active Calmodulin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry34
component stoichiometry: Stoichiometry33
component: Protein36
component: SmallMolecule15
xref: UnificationXref129
cellular location: GO:0005829
comment: Reactome DB_ID: 3653804

Adenylate cyclase (Mg2+ cofactor) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry36
component stoichiometry: Stoichiometry35
component: PhysicalEntity4
component: SmallMolecule19
xref: UnificationXref174
cellular location: GO:0005886
comment: Reactome DB_ID: 3654358

p-Raf1(S259,S621):14-3-3 protein beta/alpha (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry37
component stoichiometry: Stoichiometry38
component: Protein66
component: Protein69
xref: UnificationXref198
cellular location: GO:0005829
comment: Reactome DB_ID: 3654139

IDH1 R132mutant dimers
type: Complex
data source: Provenance1
member physical entity: IDH1 R132H dimer (name copied from entity in Homo sapiens)
xref: UnificationXref361
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656169

IDH1 R132H dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry39
component: Protein105
xref: UnificationXref360
cellular location: GO:0005829
comment: Reactome DB_ID: 3656168

pPLCgamma:PIP2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry41
component stoichiometry: Stoichiometry40
component: Protein106
component: SmallMolecule12
xref: UnificationXref371
cellular location: GO:0005886
comment: Reactome DB_ID: 3656124

PublicationXref956
type: PublicationXref
author: Donahue, TF
title: Genetic approaches to translation initiation in Saccharomyces cerevisiae.
source: Translational Control of Gene Expression. N. Sonenberg, J.W. Hershey and M.B. Mathews (eds.)487-502
year: 2000

http://identifiers.org/pubmed/14530973
type: PublicationXref
id: 14530973
author: Mackenzie, B
author: Hediger, MA
db: Pubmed
title: SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1
source: Pflugers Arch 447:571-9
year: 2004

AUF1 Dimer (isoform p37 or p40)
type: Complex
data source: Provenance1
member physical entity: Phosphorylated AUF1 p40 Dimer (name copied from entity in Homo sapiens)
member physical entity: AUF1 p37 Dimer (name copied from entity in Homo sapiens)
xref: UnificationXref856
cellular location: GO:0005829
comment: Reactome DB_ID: 3655922
comment: Converted from EntitySet in Reactome

http://identifiers.org/pubmed/18174896
type: PublicationXref
id: 18174896
author: Meisinger, C
author: Wagner, R
author: Sickmann, A
author: Pfanner, N
author: Bolender, N
db: Pubmed
title: Multiple pathways for sorting mitochondrial precursor proteins
source: EMBO Rep 9:42-9
year: 2008

Deadenylated mRNA:Lsm1-7 Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry72
component stoichiometry: Stoichiometry71
component: Lsm1-7 Complex (name copied from entity in Homo sapiens)
component: PhysicalEntity12
xref: UnificationXref844
cellular location: GO:0005829
comment: Reactome DB_ID: 3655797

ATP6V0C hexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry57
component: Protein262
xref: UnificationXref772
cellular location: GO:0010008
comment: Reactome DB_ID: 3653834

Lsm1-7 Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry63
component stoichiometry: Stoichiometry65
component stoichiometry: Stoichiometry67
component stoichiometry: Stoichiometry66
component stoichiometry: Stoichiometry64
component stoichiometry: Stoichiometry69
component stoichiometry: Stoichiometry68
component stoichiometry: Stoichiometry70
component: Protein285
component: Protein283
component: Protein284
component: Protein286
component: PhysicalEntity14
component: Protein287
component: Protein288
component: PhysicalEntity13
xref: UnificationXref843
cellular location: GO:0005829
comment: Reactome DB_ID: 3655795

V-ATPase (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry61
component stoichiometry: Stoichiometry62
component: Complex2
component: ATP6V0 (name copied from entity in Homo sapiens)
xref: UnificationXref790
cellular location: GO:0010008
comment: Reactome DB_ID: 3653885

ATP6V0 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry60
component stoichiometry: Stoichiometry59
component stoichiometry: Stoichiometry58
component stoichiometry: Stoichiometry55
component stoichiometry: Stoichiometry56
component: Protein265
component: PhysicalEntity10
component: PhysicalEntity11
component: Protein261
component: ATP6V0C hexamer (name copied from entity in Homo sapiens)
xref: UnificationXref789
cellular location: GO:0010008
comment: Reactome DB_ID: 3653842

GLUT3 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry48
component: Protein235
xref: UnificationXref611
cellular location: GO:0005886
comment: Reactome DB_ID: 3652827

GLUT1:ATP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry51
component stoichiometry: Stoichiometry50
component: GLUT1 tetramer (name copied from entity in Homo sapiens)
component: SmallMolecule46
xref: UnificationXref619
cellular location: GO:0005886
comment: Reactome DB_ID: 3655911

GLUT1, GLUT2, GLUT3, GLUT4
type: Complex
data source: Provenance1
member physical entity: GLUT2 tetramer (name copied from entity in Homo sapiens)
member physical entity: GLUT3 tetramer (name copied from entity in Homo sapiens)
member physical entity: GLUT4 tetramer (name copied from entity in Homo sapiens)
member physical entity: GLUT1 tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref612
cellular location: GO:0005886
display name: GLUT tetramers
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652832

GLUT1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry47
component: Protein232
xref: UnificationXref607
cellular location: GO:0005886
comment: Reactome DB_ID: 3652819

HuR with phosphoserine221 and phosphoserine158:mRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry127
component stoichiometry: Stoichiometry128
component: Protein337
component: PhysicalEntity22
xref: UnificationXref968
cellular location: GO:0005654
comment: Reactome DB_ID: 3656036

Phosphorylated AUF1 p40 Tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry77
component: Protein290
xref: UnificationXref860
cellular location: GO:0005829
comment: Reactome DB_ID: 3655924

http://identifiers.org/pubmed/18243674
type: PublicationXref
id: 18243674
author: Purcell, AW
author: Elliott, T
db: Pubmed
title: Molecular machinations of the MHC-I peptide loading complex
source: Curr Opin Immunol 20:75-81
year: 2008

http://identifiers.org/pubmed/9331217
type: PublicationXref
id: 9331217
author: Cooper, JA
author: Hart, MC
author: Korshunova, YO
db: Pubmed
title: Vertebrates have conserved capping protein alpha isoforms with specific expression patterns
source: Cell Motil Cytoskeleton 38:120-32
year: 1997

Ubiquitinated AUF1 Tetramer: Destabilized mRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry80
component stoichiometry: Stoichiometry82
component: PhysicalEntity15
component: Ubiquitinated AUF1 Tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref870
cellular location: GO:0005829
comment: Reactome DB_ID: 3655933

Ubiquitinated AUF1 Tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry81
component: Protein291
xref: UnificationXref869
cellular location: GO:0005829
comment: Reactome DB_ID: 3655932

26S proteasome (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry101
component stoichiometry: Stoichiometry125
component stoichiometry: Stoichiometry87
component stoichiometry: Stoichiometry104
component stoichiometry: Stoichiometry92
component stoichiometry: Stoichiometry112
component stoichiometry: Stoichiometry122
component stoichiometry: Stoichiometry119
component stoichiometry: Stoichiometry114
component stoichiometry: Stoichiometry106
component stoichiometry: Stoichiometry93
component stoichiometry: Stoichiometry105
component stoichiometry: Stoichiometry83
component stoichiometry: Stoichiometry102
component stoichiometry: Stoichiometry117
component stoichiometry: Stoichiometry109
component stoichiometry: Stoichiometry89
component stoichiometry: Stoichiometry86
component stoichiometry: Stoichiometry120
component stoichiometry: Stoichiometry91
component stoichiometry: Stoichiometry98
component stoichiometry: Stoichiometry96
component stoichiometry: Stoichiometry110
component stoichiometry: Stoichiometry123
component stoichiometry: Stoichiometry121
component stoichiometry: Stoichiometry126
component stoichiometry: Stoichiometry99
component stoichiometry: Stoichiometry90
component stoichiometry: Stoichiometry111
component stoichiometry: Stoichiometry84
component stoichiometry: Stoichiometry113
component stoichiometry: Stoichiometry118
component stoichiometry: Stoichiometry94
component stoichiometry: Stoichiometry115
component stoichiometry: Stoichiometry108
component stoichiometry: Stoichiometry116
component stoichiometry: Stoichiometry88
component stoichiometry: Stoichiometry107
component stoichiometry: Stoichiometry97
component stoichiometry: Stoichiometry103
component stoichiometry: Stoichiometry124
component stoichiometry: Stoichiometry85
component stoichiometry: Stoichiometry100
component stoichiometry: Stoichiometry95
component: Protein323
component: Protein299
component: Protein333
component: PhysicalEntity19
component: Protein308
component: Protein296
component: Protein310
component: Protein311
component: PhysicalEntity17
component: Protein309
component: Protein312
component: Protein320
component: PhysicalEntity20
component: Protein319
component: PhysicalEntity21
component: Protein318
component: Protein313
component: Protein317
component: Protein305
component: Protein294
component: Protein329
component: Protein326
component: Protein321
component: Protein306
component: Protein336
component: Protein307
component: Protein325
component: Protein315
component: Protein324
component: Protein303
component: Protein298
component: Protein316
component: Protein334
component: Protein322

Phosphorylated AUF1 p40 Dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry74
component: Protein290
xref: UnificationXref855
cellular location: GO:0005829
comment: Reactome DB_ID: 3655921

AUF1 Tetramer: Destabilized mRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry78
component stoichiometry: Stoichiometry79
component: PhysicalEntity15
component: AUF1 Tetramer (isoform p37 or p40)
xref: UnificationXref862
cellular location: GO:0005829
comment: Reactome DB_ID: 3655926

AUF1 Tetramer (isoform p37 or p40)
type: Complex
data source: Provenance1
member physical entity: AUF1 p37 Tetramer (name copied from entity in Homo sapiens)
member physical entity: Phosphorylated AUF1 p40 Tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref861
cellular location: GO:0005829
comment: Reactome DB_ID: 3655925
comment: Converted from EntitySet in Reactome

AUF1 p37 Tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry76
component: Protein289
xref: UnificationXref859
cellular location: GO:0005829
comment: Reactome DB_ID: 3655923

AUF1 p37 Dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry73
component: Protein289
xref: UnificationXref853
cellular location: GO:0005829
comment: Reactome DB_ID: 3655917

PublicationXref977
type: PublicationXref
author: Nyborg, J
author: Merrick, WC
title: The Protein Biosynthesis Elongation Cycle
source: Translational Control of Gene Expression89-127
year: 2000

http://identifiers.org/pubmed/15665109
type: PublicationXref
id: 15665109
author: Dirago, L
author: Mifsud, S
author: Hyland, C
author: Alexander, WS
author: Hilton, DJ
author: Carpinelli, MR
author: Nicola, NA
author: Metcalf, D
db: Pubmed
title: Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene
source: Blood 105:3480-7
year: 2005

Neuronal System
type: Pathway
data source: Provenance1
pathway component: Transmission across Chemical Synapses
evidence: Evidence452
xref: UnificationXref3764
xref: RelationshipXref466
xref: UnificationXref3765
pathway order: PathwayStep439
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Transmission across Chemical Synapses
type: Pathway
data source: Provenance1
pathway component: REACT 158898.3
evidence: Evidence451
xref: RelationshipXref466
xref: UnificationXref3762
xref: UnificationXref3763
pathway order: PathwayStep438
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/17956727
type: PublicationXref
id: 17956727
author: Tseng, YH
author: Kahn, CR
author: Gesta, S
db: Pubmed
title: Developmental origin of fat: tracking obesity to its source
source: Cell 131:242-56
year: 2007

RelationshipXref9
type: RelationshipXref
id: 3654596
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654596

http://identifiers.org/pubmed/224930
type: PublicationXref
id: 224930
author: Inoue, K
author: Yamasawa, K
author: Nishimukai, H
db: Pubmed
title: Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes.
source: Biochim Biophys Acta 569:117-23
year: 1979

http://identifiers.org/pubmed/18436705
type: PublicationXref
id: 18436705
author: Scheuner, D
author: Kaufman, RJ
db: Pubmed
title: The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes
source: Endocr Rev 29:317-33
year: 2008

http://identifiers.org/pubmed/22108505
type: PublicationXref
id: 22108505
author: Basler, Konrad
author: Herr, Patrick
db: Pubmed
title: Porcupine-mediated lipidation is required for Wnt recognition by Wls
source: Dev. Biol. 361:392-402
year: 2012

Proteolytic Processing of SUMO
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction392
pathway component: BiochemicalReaction390
pathway component: BiochemicalReaction391
evidence: Evidence752
xref: UnificationXref5754
xref: UnificationXref5755
pathway order: PathwayStep729
pathway order: PathwayStep728
pathway order: PathwayStep727
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref6074
type: UnificationXref
id: 3657281
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657281

UnificationXref6073
type: UnificationXref
id: REACT_154131
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154131.3

UnificationXref6076
type: UnificationXref
id: 3657226
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657226

UnificationXref6075
type: UnificationXref
id: REACT_154051
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154051.3

UnificationXref6078
type: UnificationXref
id: 3657247
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657247

UnificationXref6077
type: UnificationXref
id: REACT_113586
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113586.8

UnificationXref6079
type: UnificationXref
id: REACT_133907
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133907.5

http://identifiers.org/pubmed/10825291
type: PublicationXref
id: 10825291
author: Pepperkok, R
author: Paccaud, JP
author: Stephens, DJ
author: Lin-Marq, N
author: Pagano, A
db: Pubmed
title: COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites
source: J Cell Sci 113:2177-85
year: 2000

UnificationXref6070
type: UnificationXref
id: 3657285
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657285

UnificationXref6071
type: UnificationXref
id: REACT_155390
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155390.3

UnificationXref6072
type: UnificationXref
id: 3657280
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657280

http://identifiers.org/pubmed/22983114
type: PublicationXref
id: 22983114
author: Boutros, Michael
author: Bartscherer, Kerstin
author: Chaudhary, Varun
author: Gross, Julia Christina
db: Pubmed
title: Active Wnt proteins are secreted on exosomes
source: Nat. Cell Biol. 14:1036-45
year: 2012

http://identifiers.org/pubmed/6693436
type: PublicationXref
id: 6693436
author: Hu, SZ
author: Wang, TS
author: Korn, D
db: Pubmed
title: DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha.
source: J Biol Chem 259:1854-65
year: 1984

UnificationXref6082
type: UnificationXref
id: 3657158
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657158

UnificationXref6083
type: UnificationXref
id: REACT_101407
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101407.9

UnificationXref6080
type: UnificationXref
id: 3657248
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657248

UnificationXref6081
type: UnificationXref
id: REACT_132049
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132049.5

http://identifiers.org/pubmed/17598937
type: PublicationXref
id: 17598937
author: Matijevi?, Tanja
author: Paveli?, Jasminka
author: Knezevi?, Jelena
db: Pubmed
title: Biological & physiological aspects of action of insulin-like growth factor peptide family
source: Indian J. Med. Res. 125:511-22
year: 2007

http://identifiers.org/pubmed/9839448
type: PublicationXref
id: 9839448
author: Aureli, G
author: Federici, G
author: Petruzzelli, R
author: Ricci, G
author: Pastore, A
author: Di Ilio, C
author: Lo Bello, M
db: Pubmed
title: Purification and characterization of a novel alpha-class glutathione transferase from human liver
source: Int. J. Biochem. Cell Biol. 30:1235-43
year: 1998

UnificationXref6044
type: UnificationXref
id: 3657223
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657223

UnificationXref6045
type: UnificationXref
id: REACT_114155
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114155.8

UnificationXref6046
type: UnificationXref
id: 3655040
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655040

UnificationXref6047
type: UnificationXref
id: 3655043
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655043

UnificationXref6040
type: UnificationXref
id: 3657221
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657221

UnificationXref6041
type: UnificationXref
id: REACT_112832
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112832.8

UnificationXref6042
type: UnificationXref
id: 3657222
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657222

UnificationXref6043
type: UnificationXref
id: REACT_113178
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113178.8

RelationshipXref4
type: RelationshipXref
id: GO:0051139
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref3
type: RelationshipXref
id: GO:0090383
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2
type: RelationshipXref
id: 3656351
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656351

RelationshipXref1
type: RelationshipXref
id: GO:0015078
db: GENE ONTOLOGY
relationship type: MI:0355

Signalling by NGF
type: Pathway
data source: Provenance1
name: Nerve Growth Factor (NGF) signalling
pathway component: NGF signalling via TRKA from the plasma membrane
evidence: Evidence819
xref: UnificationXref6008
xref: UnificationXref6009
xref: RelationshipXref650
pathway order: PathwayStep792
display name: Signaling by NGF
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref6048
type: UnificationXref
id: 3655044
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655044

RelationshipXref8
type: RelationshipXref
id: GO:0004435
db: GENE ONTOLOGY
relationship type: MI:0355

Recognition and association of DNA glycosylase with site containing an affected purine
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction327
pathway component: BiochemicalReaction326
pathway component: BiochemicalReaction323
pathway component: BiochemicalReaction324
pathway component: BiochemicalReaction328
pathway component: BiochemicalReaction325
evidence: Evidence640
xref: UnificationXref5133
xref: UnificationXref5134
xref: RelationshipXref559
pathway order: PathwayStep620
pathway order: PathwayStep618
pathway order: PathwayStep615
pathway order: PathwayStep617
pathway order: PathwayStep616
pathway order: PathwayStep619
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref6049
type: UnificationXref
id: 3655045
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655045

RelationshipXref7
type: RelationshipXref
id: GO:0051701
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref6
type: RelationshipXref
id: GO:0090382
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref5
type: RelationshipXref
id: 3655807
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655807

UnificationXref6035
type: UnificationXref
id: REACT_154928
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154928.3

UnificationXref6036
type: UnificationXref
id: 3657433
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657433

UnificationXref6033
type: UnificationXref
id: REACT_154523
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154523.3

UnificationXref6034
type: UnificationXref
id: 3657432
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657432

UnificationXref6031
type: UnificationXref
id: REACT_130634
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130634.5

UnificationXref6032
type: UnificationXref
id: 3657430
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657430

UnificationXref6030
type: UnificationXref
id: 3655654
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655654

UnificationXref6039
type: UnificationXref
id: REACT_87829
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87829.9

UnificationXref6037
type: UnificationXref
id: REACT_159366
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159366.3

UnificationXref6038
type: UnificationXref
id: 3657431
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657431

PublicationXref1275
type: PublicationXref
author: Marks, F
author: Raab, I
title: The second messenger system of mouse epidermis. IV. Cyclic AMP and cyclic GMP phosphodiesterase.
source: Biochim. Biophys. Acta 334:368-377
year: 1974

COPII (Coat Protein 2) Mediated Vesicle Transport
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction290
pathway component: BiochemicalReaction292
pathway component: BiochemicalReaction291
pathway component: BiochemicalReaction289
pathway component: BiochemicalReaction288
evidence: Evidence530
xref: UnificationXref4386
xref: UnificationXref4385
xref: RelationshipXref525
pathway order: PathwayStep513
pathway order: PathwayStep514
pathway order: PathwayStep516
pathway order: PathwayStep515
pathway order: PathwayStep512
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

formamidopyrimidine
type: SmallMoleculeReference
name: 5-formamidopyrimidine
name: ChEBI:35877 5-formamidopyrimidine
xref: UnificationXref5161

UnificationXref6061
type: UnificationXref
id: REACT_168981
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_168981.1

UnificationXref6060
type: UnificationXref
id: 3657400
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657400

UnificationXref6062
type: UnificationXref
id: 3657403
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657403

UnificationXref6063
type: UnificationXref
id: REACT_166229
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_166229.1

UnificationXref6064
type: UnificationXref
id: 3657401
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657401

UnificationXref6065
type: UnificationXref
id: REACT_166603
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_166603.1

UnificationXref6066
type: UnificationXref
id: 3657402
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657402

UnificationXref6067
type: UnificationXref
id: REACT_169055
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_169055.1

UnificationXref6068
type: UnificationXref
id: 3657279
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657279

UnificationXref6069
type: UnificationXref
id: REACT_157842
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157842.3

http://identifiers.org/pubmed/3965505
type: PublicationXref
id: 3965505
author: Smith, PM
author: Schmaier, AH
author: Colman, RW
db: Pubmed
title: Platelet C1- inhibitor. A secreted alpha-granule protein.
source: J Clin Invest 75:242-50
year: 1985

http://identifiers.org/pubmed/3893466
type: PublicationXref
id: 3893466
author: Jornvall, H
db: Pubmed
title: Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes
source: Alcohol 2:61-6
year: 1985

PublicationXref1289
type: PublicationXref
author: Page, C
author: Vermylen, J
author: Fuster, V
author: Gresele, P
title: Platelets in thrombotic and non-thrombotic disorders.
source: 435-437
year: 2002

http://identifiers.org/pubmed/7890667
type: PublicationXref
id: 7890667
author: Liu, SM
author: Cheng, HF
author: Wong, LP
author: King, K
author: Jiang, MJ
author: Chen, CL
author: Lomasney, JW
db: Pubmed
title: Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis
source: J Biol Chem 270:5495-505
year: 1995

UnificationXref6050
type: UnificationXref
id: 3655046
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655046

UnificationXref6053
type: UnificationXref
id: REACT_112146
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112146.8

UnificationXref6054
type: UnificationXref
id: 3657224
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657224

Diphosphatidylglycerol
type: SmallMoleculeReference
name: cardiolipin
name: cardiolipin [ChEBI:28494]
name: cardiolipins
name: 1',3'-Bis(1,2-diacyl-sn-glycero-3-phospho)-sn-glycerol
xref: UnificationXref2078

UnificationXref6051
type: UnificationXref
id: REACT_132534
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132534.5

UnificationXref6052
type: UnificationXref
id: 3657391
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657391

UnificationXref6057
type: UnificationXref
id: REACT_126597
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126597.5

UnificationXref6058
type: UnificationXref
id: 3657225
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657225

UnificationXref6055
type: UnificationXref
id: REACT_112936
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112936.8

http://identifiers.org/pubmed/8662720
type: PublicationXref
id: 8662720
author: Korenberg, J
author: Garrow, TA
author: Qi, H
author: Choi, YJ
author: Shane, B
author: Chen, L
db: Pubmed
title: Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
source: J Biol Chem 271:13077-87
year: 1996

UnificationXref6056
type: UnificationXref
id: 3657301
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657301

UnificationXref6059
type: UnificationXref
id: REACT_78708
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78708.9

http://identifiers.org/pubmed/14500886
type: PublicationXref
id: 14500886
author: Green, S
author: Warrington, JA
author: Davis, S
author: Wolfe, CL
author: Norcum, MT
db: Pubmed
title: Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII
source: Protein Sci 12:2282-90
year: 2003

E3 ubiquitin-protein ligase synoviolin
type: Protein
entity reference: Q8ILM8
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SYVN1_HUMAN
name: SYVN1(1-617)
name: Q8ILM8
xref: UnificationXref4459
feature: FragmentFeature840
cellular location: GO:0005789
comment: Reactome DB_ID: 3656711
display name: SYVN1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IKF6
data source: Provenance1
name: KLDC3_HUMAN
name: Kelch domain-containing protein 3
name: Q8IKF6
xref: UnificationXref4451
feature: FragmentFeature839
cellular location: GO:0005829
comment: Reactome DB_ID: 3656743
display name: KLHDC3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I2W3
data source: Provenance1
name: Q8I2W3
name: TSYL2_HUMAN
name: Testis-specific Y-encoded-like protein 2
xref: UnificationXref4465
feature: FragmentFeature841
cellular location: GO:0005654
comment: Reactome DB_ID: 3656684
display name: TSPYL2

http://identifiers.org/pubmed/12941691
type: PublicationXref
id: 12941691
author: Youle, RJ
author: Sharpe, JC
author: Gaume, B
author: Arnoult, D
author: Cecconi, F
author: Karbowski, M
db: Pubmed
title: Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization.
source: EMBO J 22:4385-99
year: 2003

Homologues of TSPYL2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4472
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656691

http://identifiers.org/pubmed/1702903
type: PublicationXref
id: 1702903
author: Toyoshima, K
author: Kakiuchi, T
author: Yamanashi, Y
author: Mizuguchi, J
author: Yamamoto, T
db: Pubmed
title: Association of B cell antigen receptor with protein tyrosine kinase Lyn
source: Science 251:192-4
year: 1991

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q9Y010
data source: Provenance1
name: TSYL2_HUMAN
name: Testis-specific Y-encoded-like protein 2
name: Q9Y010
xref: UnificationXref4469
feature: FragmentFeature843
cellular location: GO:0005654
comment: Reactome DB_ID: 3656688
display name: TSPYL2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O76970
data source: Provenance1
name: O76970
name: TSYL2_HUMAN
name: Testis-specific Y-encoded-like protein 2
xref: UnificationXref4467
feature: FragmentFeature842
cellular location: GO:0005654
comment: Reactome DB_ID: 3656686
display name: TSPYL2

UnificationXref6009
type: UnificationXref
id: REACT_112151
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112151.8

UnificationXref6008
type: UnificationXref
id: 3657230
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657230

UnificationXref6005
type: UnificationXref
id: REACT_114294
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114294.8

UnificationXref6004
type: UnificationXref
id: 3657228
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657228

UnificationXref6007
type: UnificationXref
id: REACT_112103
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112103.8

UnificationXref6006
type: UnificationXref
id: 3657229
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657229

UnificationXref6001
type: UnificationXref
id: REACT_153434
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153434.3

UnificationXref6000
type: UnificationXref
id: 3657289
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657289

UnificationXref6003
type: UnificationXref
id: REACT_154914
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154914.3

UnificationXref6002
type: UnificationXref
id: 3657287
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657287

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I9F4
data source: Provenance1
name: TSYL2_HUMAN
name: Q8I9F4
name: Testis-specific Y-encoded-like protein 2
xref: UnificationXref4471
feature: FragmentFeature844
cellular location: GO:0005654
comment: Reactome DB_ID: 3656690
display name: TSPYL2

Homologues of COPB2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q8I390
xref: UnificationXref4496
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654990

Q8I390
type: Protein
entity reference: Q8I390
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Coatomer beta' subunit
xref: UnificationXref4493
feature: FragmentFeature845
cellular location: GO:0005829
comment: Reactome DB_ID: 3654987
display name: COPB2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6WWJ3
data source: Provenance1
name: Q6WWJ3
name: Coatomer beta' subunit
xref: UnificationXref4495
feature: FragmentFeature846
cellular location: GO:0005829
comment: Reactome DB_ID: 3654989
display name: COPB2

Homologues of ARCN1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4501
cellular location: GO:0005829
comment: Reactome DB_ID: 3654997
comment: Converted from EntitySet in Reactome

Q8IHR6
type: Protein
entity reference: Q8IHR6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Coatomer gamma subunit
xref: UnificationXref4505
feature: FragmentFeature850
cellular location: GO:0005829
comment: Reactome DB_ID: 3655008
display name: COPG1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I1T3
data source: Provenance1
name: Coatomer zeta-1 subunit
name: Q8I1T3
xref: UnificationXref4503
feature: FragmentFeature849
cellular location: GO:0005829
comment: Reactome DB_ID: 3655012
display name: COPZ1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8MV47
data source: Provenance1
name: Coatomer delta subunit
name: Q8MV47
xref: UnificationXref4500
feature: FragmentFeature848
cellular location: GO:0005829
comment: Reactome DB_ID: 3654996
display name: ARCN1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8II16
data source: Provenance1
name: Coatomer delta subunit
name: Q8II16
xref: UnificationXref4498
feature: FragmentFeature847
cellular location: GO:0005829
comment: Reactome DB_ID: 3654994
display name: ARCN1

http://identifiers.org/pubmed/11604561
type: PublicationXref
id: 11604561
author: Cattaneo, M
author: Ruggeri, ZM
author: Savage, B
db: Pubmed
title: Mechanisms of platelet aggregation
source: Curr Opin Hematol 8:270-6
year: 2001

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C6KSR5
data source: Provenance1
name: Coatomer alpha subunit
name: C6KSR5
xref: UnificationXref4507
feature: FragmentFeature851
cellular location: GO:0005829
comment: Reactome DB_ID: 3654979
display name: COPA

UniProt:Q14RW4
type: ProteinReference
xref: UnificationXref3037
organism: BioSource1

http://identifiers.org/pubmed/16746585
type: PublicationXref
id: 16746585
author: Salvin, E
author: Johnson, WA
author: Krebs, HA
db: Pubmed
title: The formation of citric and alpha-ketoglutaric acids in the mammalian body
source: Biochem J 32:113-117
year: 1938

Homologues of COPE
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q2KNS1
xref: UnificationXref4512
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655004

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H4T1
data source: Provenance1
name: C0H4T1
name: Coatomer epsilon subunit
xref: UnificationXref4509
feature: FragmentFeature852
cellular location: GO:0005829
comment: Reactome DB_ID: 3655001
display name: COPE

Homologues of YWHAH
type: Protein
data source: Provenance1
member physical entity: 14-3-3 protein eta
xref: UnificationXref4531
cellular location: GO:0005829
comment: Reactome DB_ID: 3656421
comment: Converted from EntitySet in Reactome

14-3-3 protein eta
type: Protein
entity reference: O61132
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: O61132
name: 14-3-3 eta
name: 1433F_HUMAN
xref: UnificationXref4529
feature: FragmentFeature855
cellular location: GO:0005829
comment: Reactome DB_ID: 3656419
display name: YWHAH

http://identifiers.org/pubmed/19489725
type: PublicationXref
id: 19489725
author: Joazeiro, CA
author: Deshaies, RJ
db: Pubmed
title: RING domain E3 ubiquitin ligases
source: Annu Rev Biochem 78:399-434
year: 2009

Q2KNS1
type: Protein
entity reference: Q2KNS1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Coatomer epsilon subunit
xref: UnificationXref4511
feature: FragmentFeature853
cellular location: GO:0005829
comment: Reactome DB_ID: 3655003
display name: COPE

Q8ILG6
type: Protein
entity reference: Q8ILG6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Coatomer beta subunit
xref: UnificationXref4514
feature: FragmentFeature854
cellular location: GO:0005829
comment: Reactome DB_ID: 3654983
display name: COPB1

http://identifiers.org/pubmed/8618861
type: PublicationXref
id: 8618861
author: Nevins, JR
author: DeGregori, J
author: Ohtani, K
db: Pubmed
title: Regulation of the cyclin E gene by transcription factor E2F1
source: Proc Natl Acad Sci U S A 92:12146-50
year: 1995

Peroxisomal lipid metabolism
type: Pathway
data source: Provenance1
pathway component: NADPH regeneration
evidence: Evidence220
xref: UnificationXref1854
xref: UnificationXref1853
xref: RelationshipXref182
pathway order: PathwayStep214
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref6027
type: UnificationXref
id: REACT_154603
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154603.3

UnificationXref403
type: UnificationXref
id: 3657297
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657297

UnificationXref6026
type: UnificationXref
id: 3657304
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657304

UnificationXref402
type: UnificationXref
id: REACT_159856
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159856.3

UnificationXref6029
type: UnificationXref
id: REACT_157021
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157021.3

UnificationXref405
type: UnificationXref
id: CHEBI:17544
db: ChEBI

UnificationXref6028
type: UnificationXref
id: 3655611
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655611

UnificationXref404
type: UnificationXref
id: REACT_114377
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114377.8

UnificationXref401
type: UnificationXref
id: 3657496
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657496

UnificationXref400
type: UnificationXref
id: REACT_159440
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159440.3

UnificationXref6021
type: UnificationXref
id: REACT_118472
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118472.7

UnificationXref6020
type: UnificationXref
id: 3657241
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657241

UnificationXref6023
type: UnificationXref
id: REACT_118552
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118552.7

UnificationXref6022
type: UnificationXref
id: 3657242
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657242

UnificationXref6025
type: UnificationXref
id: REACT_159106
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159106.3

UnificationXref6024
type: UnificationXref
id: 3657303
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657303

MPS IIID - Sanfilippo syndrome D
type: Pathway
data source: Provenance1
pathway component: REACT 153330.3
evidence: Evidence35
xref: UnificationXref312
xref: UnificationXref311
pathway order: PathwayStep29
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref6018
type: UnificationXref
id: 3657306
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657306

UnificationXref6017
type: UnificationXref
id: REACT_153280
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153280.3

UnificationXref6016
type: UnificationXref
id: 3657302
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657302

UnificationXref6015
type: UnificationXref
id: REACT_158593
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158593.3

http://identifiers.org/pubmed/1756912
type: PublicationXref
id: 1756912
author: Morgan, R
author: Rees, A
author: Choi, WH
author: Moller, DE
author: O'Rahilly, S
author: Buse, JB
author: Flier, JS
db: Pubmed
title: Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects
source: Diabetes 40:1712-8
year: 1991

UnificationXref6019
type: UnificationXref
id: REACT_152977
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152977.3

UnificationXref6010
type: UnificationXref
id: 3657231
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657231

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P33948
data source: Provenance1
name: ERD23_HUMAN
name: ER lumen protein retaining receptor 3
name: P33948
xref: UnificationXref4444
feature: FragmentFeature837
cellular location: GO:0005789
comment: Reactome DB_ID: 3656723
display name: KDELR3

http://identifiers.org/pubmed/11481335
type: PublicationXref
id: 11481335
author: Lardizabal, KD
author: Cases, S
author: Tow, B
author: Zhou, P
author: Farese, RV
author: Voelker, T
author: Yen, E
author: Stone, SJ
db: Pubmed
title: Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members
source: J Biol Chem 276:38870-6
year: 2001

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q76NM1
data source: Provenance1
name: ERD23_HUMAN
name: ER lumen protein retaining receptor 3
name: Q76NM1
xref: UnificationXref4446
feature: FragmentFeature838
cellular location: GO:0005789
comment: Reactome DB_ID: 3656725
display name: KDELR3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H5H0
data source: Provenance1
name: HYOU1_HUMAN
name: C0H5H0
name: Hypoxia up-regulated protein 1
xref: UnificationXref4440
feature: FragmentFeature836
cellular location: GO:0005788
comment: Reactome DB_ID: 3656701
display name: HYOU1

Homologues of KDELR3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4447
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656726

UnificationXref6014
type: UnificationXref
id: 3657305
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657305

UnificationXref6013
type: UnificationXref
id: REACT_114156
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114156.8

UnificationXref6012
type: UnificationXref
id: 3657232
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657232

UnificationXref6011
type: UnificationXref
id: REACT_114220
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114220.8

Homologues of POLR2A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4605
cellular location: GO:0005654
comment: Reactome DB_ID: 3653132
comment: Converted from EntitySet in Reactome

NCBP 20 kDa subunit
type: Protein
entity reference: Q8I1T2
data source: Provenance1
name: 20 kDa nuclear cap binding protein
name: NCBP2
name: Note: the coordinates are copied over from Homo sapiens.
name: NCBP interacting protein 1
name: CBP20
name: Q8I1T2
name: 20 kDa nuclear cap binding protein (NCBP 20 kDa subunit) (CBP20) (NCBP interacting protein 1) (NIP1)
xref: UnificationXref4596
feature: FragmentFeature879
cellular location: GO:0005654
comment: Reactome DB_ID: 3653058
display name: NIP1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8ID59
data source: Provenance1
name: DNA-directed RNA polymerase II 23 kDa polypeptide (EC 2.7.7.6) (RPB25) (XAP4) (RPB5)
name: POLR2E
name: HsRPABC1
name: RPABC1
name: RPB5
name: RPB25
name: DNA-directed RNA polymerase II 23 kDa polypeptide
name: Q8ID59
xref: UnificationXref4589
feature: FragmentFeature878
cellular location: GO:0005654
comment: Reactome DB_ID: 3653111
display name: XAP4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O96236
data source: Provenance1
name: DNA-directed RNA polymerase II 140 kDa polypeptide
name: O96236
name: RNA polymerase II subunit 2
name: POLR2B
xref: UnificationXref4587
feature: FragmentFeature877
cellular location: GO:0005654
comment: Reactome DB_ID: 3653090
display name: RPB2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C6F0A4
data source: Provenance1
name: RNA Pol II (unphosphorylated) largest subunit
name: C6F0A4
name: DNA-directed RNA polymerase II largest subunit
name: POLR2A
xref: UnificationXref4603
feature: FragmentFeature883
cellular location: GO:0005654
comment: Reactome DB_ID: 3653130
display name: RPB1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C6F0B0
data source: Provenance1
name: RNA Pol II (unphosphorylated) largest subunit
name: C6F0B0
name: DNA-directed RNA polymerase II largest subunit
name: POLR2A
xref: UnificationXref4602
feature: FragmentFeature882
cellular location: GO:0005654
comment: Reactome DB_ID: 3653129
display name: RPB1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O77375
data source: Provenance1
name: RNA Pol II (unphosphorylated) largest subunit
name: O77375
name: DNA-directed RNA polymerase II largest subunit
name: POLR2A
xref: UnificationXref4601
feature: FragmentFeature881
cellular location: GO:0005654
comment: Reactome DB_ID: 3653128
display name: RPB1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C6F0A3
data source: Provenance1
name: RNA Pol II (unphosphorylated) largest subunit
name: C6F0A3
name: DNA-directed RNA polymerase II largest subunit
name: POLR2A
xref: UnificationXref4600
feature: FragmentFeature880
cellular location: GO:0005654
comment: Reactome DB_ID: 3653127
display name: RPB1

UnificationXref422
type: UnificationXref
id: 3655447
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655447

UnificationXref423
type: UnificationXref
id: 3655449
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655449

UnificationXref420
type: UnificationXref
id: 3655443
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655443

UnificationXref421
type: UnificationXref
id: 3655445
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655445

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IJC9
data source: Provenance1
name: POLR2G
name: DNA-directed RNA polymerase II 19 kDa polypeptide
name: Q8IJC9
xref: UnificationXref4585
feature: FragmentFeature876
cellular location: GO:0005654
comment: Reactome DB_ID: 3653098
display name: RPB7

UnificationXref426
type: UnificationXref
id: 3655455
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655455

UnificationXref427
type: UnificationXref
id: 3655457
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655457

UnificationXref424
type: UnificationXref
id: 3655451
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655451

UnificationXref425
type: UnificationXref
id: 3655453
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655453

UnificationXref419
type: UnificationXref
id: 3655441
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655441

UnificationXref418
type: UnificationXref
id: 3655439
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655439

UnificationXref417
type: UnificationXref
id: 3655437
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655437

http://identifiers.org/pubmed/11051212
type: PublicationXref
id: 11051212
author: Szkopinska, A
db: Pubmed
title: Ubiquinone. Biosynthesis of quinone ring and its isoprenoid side chain. Intracellular localization
source: Acta Biochim Pol 47:469-80
year: 2000

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O77315
data source: Provenance1
name: DNA-directed RNA polymerase II 14.4 kDa polypeptide (EC 2.7.7.6) (RPB6) (RPB14.4)
name: RPB14.4
name: DNA-directed RNA polymerase II 14.4 kDa polypeptide
name: HsRPABC2
name: POLR2F(1-127)
name: RPABC2
name: O77315
xref: UnificationXref4581
feature: FragmentFeature874
cellular location: GO:0005654
comment: Reactome DB_ID: 3653115
display name: RPB6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O96150
data source: Provenance1
name: DNA-directed RNA polymerase II 16 kDa polypeptide
name: POLR2D(2-142)
name: O96150
xref: UnificationXref4583
feature: FragmentFeature875
cellular location: GO:0005654
comment: Reactome DB_ID: 3653094
display name: RPB4

http://identifiers.org/pubmed/8617750
type: PublicationXref
id: 8617750
author: Green, JM
author: Cohen, BD
author: Fell, HP
author: Foy, L
db: Pubmed
title: HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers
source: J Biol Chem 271:4813-8
year: 1996

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IDJ7
data source: Provenance1
name: Small nuclear ribonucleoprotein E
name: snRNP E
name: RUXE_HUMAN
name: Q8IDJ7
name: Sm protein E
name: snRNP-E
name: SNRPE
name: Sm-E
xref: UnificationXref4625
feature: FragmentFeature888
cellular location: GO:0005654
comment: Reactome DB_ID: 3653896
display name: SmE

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8IB57
data source: Provenance1
name: RUXG_HUMAN
name: Sm-G
name: snRNP G
name: snRNP-G
name: Q8IB57
name: Small nuclear ribonucleoprotein G
name: Sm protein G
name: SNRPG
xref: UnificationXref4623
feature: FragmentFeature887
cellular location: GO:0005654
comment: Reactome DB_ID: 3653904
display name: SmG

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IIA8
data source: Provenance1
name: snRNP core protein D1
name: 2xMe-SNRPD1
name: Small nuclear ribonucleoprotein Sm D1
name: dimethylated Sm protein D1
name: Sm-D autoantigen
name: Q8IIA8
xref: UnificationXref4629
feature: ModificationFeature62
feature: FragmentFeature890
cellular location: GO:0005654
comment: Reactome DB_ID: 3653914
display name: Sm-D1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8ILU8
data source: Provenance1
name: snRNP-B
name: dimethylated Sm Protein B
name: SmB/SmB'
name: Sm-B/Sm-B'
name: Sm protein B/B'
name: 2xMe-SNRPB
name: Small nuclear ribonucleoprotein associated proteins B and B'
xref: UnificationXref4627
feature: FragmentFeature889
feature: ModificationFeature61
cellular location: GO:0005654
comment: Reactome DB_ID: 3653909
display name: Q8ILU8

O96265
type: Protein
entity reference: UniProt:O96265
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: snRNP core protein D2
name: SNRPD2
name: Small nuclear ribonucleoprotein Sm D2
name: SMD2_HUMAN
name: Sm protein D2
xref: UnificationXref4633
feature: FragmentFeature892
cellular location: GO:0005654
comment: Reactome DB_ID: 3653892
display name: Sm-D2

snRNP F
type: Protein
entity reference: Q8II94
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8II94
name: Sm protein F
name: RUXF_HUMAN
name: SNRPF
name: Small nuclear ribonucleoprotein F
name: Sm-F
name: snRNP-F
xref: UnificationXref4631
feature: FragmentFeature891
cellular location: GO:0005654
comment: Reactome DB_ID: 3653900
display name: SmF

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H4X1
data source: Provenance1
name: U5-40 kDa protein
name: SNRNP40
xref: UnificationXref4643
feature: FragmentFeature894
cellular location: GO:0005654
comment: Reactome DB_ID: 3653969
display name: C0H4X1

Glycolysis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction47
pathway component: BiochemicalReaction45
pathway component: BiochemicalReaction49
pathway component: BiochemicalReaction44
pathway component: BiochemicalReaction48
pathway component: BiochemicalReaction46
evidence: Evidence136
xref: UnificationXref1319
xref: RelationshipXref97
xref: UnificationXref1320
pathway order: PathwayStep129
pathway order: PathwayStep127
pathway order: PathwayStep126
pathway order: PathwayStep128
pathway order: PathwayStep125
pathway order: PathwayStep130
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I1X5
data source: Provenance1
name: Q8I1X5
name: hPrp8
xref: UnificationXref4641
feature: FragmentFeature893
cellular location: GO:0005654
comment: Reactome DB_ID: 3653997
display name: PRPF8

UnificationXref410
type: UnificationXref
id: REACT_2728
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2728.2

http://identifiers.org/pubmed/18043707
type: PublicationXref
id: 18043707
author: Hamm, HE
author: Oldham, WM
db: Pubmed
title: Heterotrimeric G protein activation by G-protein-coupled receptors
source: Nat Rev Mol Cell Biol 9:60-71
year: 2008

UnificationXref411
type: UnificationXref
id: CHEBI:16761
db: ChEBI

UnificationXref412
type: UnificationXref
id: 29370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370

UnificationXref413
type: UnificationXref
id: REACT_2741
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2741.1

UniProt:O97467
type: ProteinReference
xref: UnificationXref386
organism: BioSource1

UnificationXref414
type: UnificationXref
id: 425425
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425425

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H529
data source: Provenance1
name: snRNP core protein D3
name: 2xMe-SNRPD3
name: C0H529
name: dimethylated Sm protein D3
name: Small nuclear ribonucleoprotein Sm D3
name: SMD3_HUMAN
xref: UnificationXref4621
feature: ModificationFeature60
feature: FragmentFeature886
cellular location: GO:0005654
comment: Reactome DB_ID: 3653919
display name: Sm-D3

UnificationXref415
type: UnificationXref
id: REACT_19959
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19959.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8I6Z2
data source: Provenance1
name: MT-A70
name: Methyltransferase-like protein 3
name: Q8I6Z2
name: N6-adenosine-methyltransferase 70 kDa subunit
xref: UnificationXref4613
feature: FragmentFeature885
cellular location: GO:0005654
comment: Reactome DB_ID: 3653139
display name: METTL3

UnificationXref416
type: UnificationXref
id: 3655433
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655433

UnificationXref407
type: UnificationXref
id: REACT_4357
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4357.1

UnificationXref406
type: UnificationXref
id: 111627
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111627

UnificationXref409
type: UnificationXref
id: 29372
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372

UnificationXref408
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C6F0A2
data source: Provenance1
name: RNA Pol II (unphosphorylated) largest subunit
name: C6F0A2
name: DNA-directed RNA polymerase II largest subunit
name: POLR2A
xref: UnificationXref4604
feature: FragmentFeature884
cellular location: GO:0005654
comment: Reactome DB_ID: 3653131
display name: RPB1

phospho-p-S237-TBC1D1
type: Protein
entity reference: Q8I435
data source: Provenance1
xref: UnificationXref4548
feature: ModificationFeature54
feature: FragmentFeature863
cellular location: GO:0005829
comment: Reactome DB_ID: 3656441

UnificationXref440
type: UnificationXref
id: 3655483
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655483

C0H4V6
type: Protein
entity reference: C0H4V6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: 14-3-3 zeta
xref: UnificationXref4542
feature: FragmentFeature862
cellular location: GO:0005829
comment: Reactome DB_ID: 3655800
display name: YWHAZ

UnificationXref441
type: UnificationXref
id: 3655485
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655485

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O61132
data source: Provenance1
name: O61132
name: 14-3-3 zeta
xref: UnificationXref4541
feature: FragmentFeature861
cellular location: GO:0005829
comment: Reactome DB_ID: 3655799
display name: YWHAZ

Homologues of YWHAZ
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: C0H4V6
xref: UnificationXref4543
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655801

14-3-3 sigma
type: Protein
entity reference: C0H4V6
data source: Provenance1
name: C0H4V6
name: Note: the coordinates are copied over from Homo sapiens.
name: 1433S_HUMAN
name: 14-3-3 protein sigma
xref: UnificationXref4538
feature: FragmentFeature860
cellular location: GO:0005829
comment: Reactome DB_ID: 3656428
display name: SFN

14-3-3 sigma
type: Protein
entity reference: O61132
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: O61132
name: 1433S_HUMAN
name: 14-3-3 protein sigma
xref: UnificationXref4537
feature: FragmentFeature859
cellular location: GO:0005829
comment: Reactome DB_ID: 3656427
display name: SFN

Regulation of DNA replication
type: Pathway
data source: Provenance1
pathway component: Removal of licensing factors from origins
evidence: Evidence610
xref: UnificationXref5026
xref: UnificationXref5027
pathway order: PathwayStep593
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Homologues of SFN
type: Protein
data source: Provenance1
member physical entity: 14-3-3 sigma
xref: UnificationXref4539
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656429

UnificationXref448
type: UnificationXref
id: 3655499
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655499

UnificationXref449
type: UnificationXref
id: 3655500
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655500

UnificationXref446
type: UnificationXref
id: 3655495
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655495

UnificationXref447
type: UnificationXref
id: 3655497
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655497

UnificationXref444
type: UnificationXref
id: 3655491
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655491

UnificationXref445
type: UnificationXref
id: 3655493
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655493

UnificationXref442
type: UnificationXref
id: 3655487
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655487

UnificationXref443
type: UnificationXref
id: 3655489
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655489

http://identifiers.org/pubmed/9551553
type: PublicationXref
id: 9551553
author: McKinstry, W J
author: Rossjohn, J
author: Board, P G
author: Chelvanayagam, G
author: Parker, M W
author: Verger, D
author: Flanagan, J
author: Tan, K L
author: Oakley, A J
db: Pubmed
title: Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site
source: Structure 6:309-22
year: 1998

UnificationXref439
type: UnificationXref
id: 3655481
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655481

14-3-3 protein gamma
type: Protein
entity reference: O61132
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: O61132
name: YWHAG(1-247)
name: 14-3-3 gamma
xref: UnificationXref4533
feature: FragmentFeature857
cellular location: GO:0005829
comment: Reactome DB_ID: 3656423
display name: YWHAG

14-3-3 protein gamma
type: Protein
entity reference: C0H4V6
data source: Provenance1
name: C0H4V6
name: Note: the coordinates are copied over from Homo sapiens.
name: YWHAG(1-247)
name: 14-3-3 gamma
xref: UnificationXref4534
feature: FragmentFeature858
cellular location: GO:0005829
comment: Reactome DB_ID: 3656424
display name: YWHAG

14-3-3 protein eta
type: Protein
entity reference: C0H4V6
data source: Provenance1
name: C0H4V6
name: Note: the coordinates are copied over from Homo sapiens.
name: 14-3-3 eta
name: 1433F_HUMAN
xref: UnificationXref4530
feature: FragmentFeature856
cellular location: GO:0005829
comment: Reactome DB_ID: 3656420
display name: YWHAH

Homologues of YWHAG(1-247)
type: Protein
data source: Provenance1
member physical entity: 14-3-3 protein gamma
xref: UnificationXref4535
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656425

phospho-p-S5-POLR2A
type: Protein
entity reference: C6F0A4
data source: Provenance1
xref: UnificationXref4574
feature: FragmentFeature871
feature: ModificationFeature58
cellular location: GO:0005654
comment: Reactome DB_ID: 3653074

phospho-p-S5-POLR2A
type: Protein
entity reference: C6F0B0
data source: Provenance1
xref: UnificationXref4572
feature: FragmentFeature870
feature: ModificationFeature57
cellular location: GO:0005654
comment: Reactome DB_ID: 3653071

Q8IC08
type: Protein
entity reference: UniProt:Q8IC08
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DNA-directed RNA polymerase II 7.6 kDa polypeptide
name: HsRPABC5
name: RPABC5
name: POLR2L
name: DNA-directed RNA polymerase II 7.6 kDa polypeptide (EC 2.7.7.6) (RPB10) (RPB7.6)
name: RPB7.6
xref: UnificationXref4579
feature: FragmentFeature873
cellular location: GO:0005654
comment: Reactome DB_ID: 3653119
display name: RPB10

phospho-p-S5-POLR2A
type: Protein
entity reference: C6F0A2
data source: Provenance1
xref: UnificationXref4576
feature: ModificationFeature59
feature: FragmentFeature872
cellular location: GO:0005654
comment: Reactome DB_ID: 3653077

UnificationXref430
type: UnificationXref
id: 3655463
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655463

Homologues of p-S5-POLR2A
type: Protein
data source: Provenance1
member physical entity: phospho-p-S5-POLR2A
xref: UnificationXref4577
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3653078

http://identifiers.org/pubmed/5940
type: PublicationXref
id: 5940
author: Povey, S
author: Wilson, Jr, DE
author: Harris, H
db: Pubmed
title: Adenylate kinases in man: evidence for a third locus
source: Ann Hum Genet 39:305-313
year: 1976

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IER7
data source: Provenance1
name: DNA-directed RNA polymerase II 13.3 kDa polypeptide
name: POLR2J
name: Q8IER7
xref: UnificationXref4566
feature: FragmentFeature867
cellular location: GO:0005654
comment: Reactome DB_ID: 3653082
display name: RPB11

phospho-p-S5-POLR2A
type: Protein
entity reference: O77375
data source: Provenance1
xref: UnificationXref4570
feature: ModificationFeature56
feature: FragmentFeature869
cellular location: GO:0005654
comment: Reactome DB_ID: 3653068

phospho-p-S5-POLR2A
type: Protein
entity reference: C6F0A3
data source: Provenance1
xref: UnificationXref4568
feature: FragmentFeature868
feature: ModificationFeature55
cellular location: GO:0005654
comment: Reactome DB_ID: 3653065

UnificationXref435
type: UnificationXref
id: 3655473
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655473

UnificationXref436
type: UnificationXref
id: 3655475
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655475

UnificationXref437
type: UnificationXref
id: 3655477
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655477

UnificationXref438
type: UnificationXref
id: 3655479
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655479

UnificationXref431
type: UnificationXref
id: 3655465
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655465

UnificationXref432
type: UnificationXref
id: 3655467
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655467

UnificationXref433
type: UnificationXref
id: 3655469
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655469

UnificationXref434
type: UnificationXref
id: 3655471
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655471

http://identifiers.org/pubmed/15798894
type: PublicationXref
id: 15798894
author: Kim, CM
author: Ro, S
author: Jeon, YH
author: Heo, YS
author: Cho, JM
author: Hyun, YL
author: Lee, TG
db: Pubmed
title: Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development
source: Cell Mol Life Sci 62:1198-220
year: 2005

UnificationXref429
type: UnificationXref
id: 3655461
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655461

UnificationXref428
type: UnificationXref
id: 3655459
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655459

PublicationXref1207
type: PublicationXref
author: Thompson, L
author: Limoli, L
title: Origin, Recognition, Signaling and Repair of DNA Double-Strand Breaks in Mammalian Cells
source: Damage Surveillance and Repair (Keith Caldecott, editor)1-40
year: 2003

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I2S6
data source: Provenance1
name: RNA polymerase II subunit 3
name: RPB31
name: RPB33
name: DNA-directed RNA polymerase II 33 kDa polypeptide
name: POLR2C
name: Q8I2S6
xref: UnificationXref4560
feature: FragmentFeature864
cellular location: GO:0005654
comment: Reactome DB_ID: 3653102
display name: RPB3

RPB14.5
type: Protein
entity reference: Q8I241
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: POLR2I
name: Q8I241
name: DNA-directed RNA polymerase II 14.5 kDa polypeptide
xref: UnificationXref4562
feature: FragmentFeature865
cellular location: GO:0005654
comment: Reactome DB_ID: 3653086
display name: RPB9

POLR2H
type: Protein
entity reference: Q8I5R8
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide
name: RPABC3
name: RPB17
name: Q8I5R8
xref: UnificationXref4564
feature: FragmentFeature866
cellular location: GO:0005654
comment: Reactome DB_ID: 3653106
display name: RPB8

UnificationXref467
type: UnificationXref
id: Q25693
db: UniProt

Q8I615
type: Protein
entity reference: Q8I615
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Origin recognition complex subunit 1
name: Replication control protein 1
name: Orc1
xref: UnificationXref4709
feature: FragmentFeature913
cellular location: GO:0005654
comment: Reactome DB_ID: 3652485
display name: ORC1

UnificationXref466
type: UnificationXref
id: 3656410
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656410

UnificationXref465
type: UnificationXref
id: Q8IKZ6
db: UniProt

UnificationXref464
type: UnificationXref
id: 3656408
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656408

Q7KQJ9
type: Protein
entity reference: Q7KQJ9
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cyclin
name: Proliferating cell nuclear antigen
xref: UnificationXref4713
feature: FragmentFeature915
cellular location: GO:0005654
comment: Reactome DB_ID: 3652761
display name: PCNA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P61074
data source: Provenance1
name: Cyclin
name: P61074
name: Proliferating cell nuclear antigen
xref: UnificationXref4715
feature: FragmentFeature916
cellular location: GO:0005654
comment: Reactome DB_ID: 3652765
display name: PCNA

Homologues of PCNA
type: Protein
data source: Provenance1
member physical entity: Q7KQJ9
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4716
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652766

UnificationXref469
type: UnificationXref
id: Q25919
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8WSN0
data source: Provenance1
name: Cyclin
name: Q8WSN0
name: Proliferating cell nuclear antigen
xref: UnificationXref4711
feature: FragmentFeature914
cellular location: GO:0005654
comment: Reactome DB_ID: 3652759
display name: PCNA

UnificationXref468
type: UnificationXref
id: 3656412
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656412

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9TX75
data source: Provenance1
name: DNA polymerase alpha catalytic subunit
name: Q9TX75
name: POLA1
xref: UnificationXref4720
feature: FragmentFeature918
cellular location: GO:0005654
comment: Reactome DB_ID: 3652394
display name: p180

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q53IG9
data source: Provenance1
name: DNA polymerase alpha catalytic subunit
name: POLA1
name: Q53IG9
xref: UnificationXref4722
feature: FragmentFeature919
cellular location: GO:0005654
comment: Reactome DB_ID: 3652396
display name: p180

Homologues of POLA1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4733
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652407

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q53IG5
data source: Provenance1
name: DNA polymerase alpha catalytic subunit
name: POLA1
name: Q53IG5
xref: UnificationXref4718
feature: FragmentFeature917
cellular location: GO:0005654
comment: Reactome DB_ID: 3652392
display name: p180

UnificationXref463
type: UnificationXref
id: Q7Z1F1
db: UniProt

UnificationXref462
type: UnificationXref
id: 3656406
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656406

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q53IG7
data source: Provenance1
name: DNA polymerase alpha catalytic subunit
name: POLA1
name: Q53IG7
xref: UnificationXref4724
feature: FragmentFeature920
cellular location: GO:0005654
comment: Reactome DB_ID: 3652398
display name: p180

UnificationXref461
type: UnificationXref
id: Q7Z1F2
db: UniProt

UnificationXref460
type: UnificationXref
id: 3656404
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656404

UnificationXref454
type: UnificationXref
id: REACT_111450
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111450.1

UnificationXref453
type: UnificationXref
id: 1369066
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1369066

UnificationXref456
type: UnificationXref
id: 1369027
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1369027

UnificationXref455
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

UnificationXref458
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

UnificationXref457
type: UnificationXref
id: REACT_111818
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111818.1

UnificationXref459
type: UnificationXref
id: Q08667
db: UniProt

UnificationXref450
type: UnificationXref
id: 3655502
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655502

UnificationXref452
type: UnificationXref
id: CHEBI:8337
db: ChEBI

UnificationXref451
type: UnificationXref
id: REACT_144718
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144718.5

http://identifiers.org/pubmed/5666113
type: PublicationXref
id: 5666113
author: Luzzatto, L
author: Afolayan, A
db: Pubmed
title: Enzymic properties of different types of human erythrocyte glucose-6-phosphate dehydrogenase, with characterization of two new genetic variants
source: J Clin Invest 47:1833-42
year: 1968

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IIC4
data source: Provenance1
name: High mobility group-like nuclear protein 2 homolog 1
name: (U4/U6.U5) tri-snRNP 15.5 kDa protein
name: NHP2L1
name: tri-snRNP 15.5 kDa protein
name: NHP2-like protein 1
name: Q8IIC4
xref: UnificationXref4647
feature: FragmentFeature896
cellular location: GO:0005654
comment: Reactome DB_ID: 3653989
display name: OTK27

U5 snRNP-associated 102 kDa protein
type: Protein
entity reference: Q8IIR0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PRPU_HUMAN
name: U5-102 kDa protein
name: Q8IIR0
xref: UnificationXref4649
feature: FragmentFeature897
cellular location: GO:0005654
comment: Reactome DB_ID: 3653977
display name: PRPF6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I5A5
data source: Provenance1
name: DIM1_HUMAN
name: Q8I5A5
name: Spliceosomal U5 snRNP-specific 15 kDa protein
name: Thioredoxin-like U5 snRNP protein U5-15kD
name: DIM1 protein homolog
name: TXNL4A
xref: UnificationXref4645
feature: FragmentFeature895
cellular location: GO:0005654
comment: Reactome DB_ID: 3653965
display name: DIM1

UnificationXref489
type: UnificationXref
id: 3656452
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656452

UnificationXref488
type: UnificationXref
id: 3656451
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656451

UnificationXref487
type: UnificationXref
id: 3656450
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656450

UnificationXref486
type: UnificationXref
id: 3656449
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656449

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I3T5
data source: Provenance1
name: Splicing factor, arginine/serine-rich 1
name: Q8I3T5
name: Splicing factor, arginine/serine-rich 1 (pre-mRNA splicing factor SF2, P33 subunit) (Alternative splicing factor ASF-1)
name: Alternative splicing factor ASF-1
name: pre-mRNA splicing factor SF2, P33 subunit
name: SF2/ASF/SFRS1
xref: UnificationXref4666
feature: FragmentFeature903
cellular location: GO:0005654
comment: Reactome DB_ID: 3653932
display name: SRSF1

UnificationXref485
type: UnificationXref
id: 3656448
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656448

UnificationXref484
type: UnificationXref
id: 3656447
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656447

Homologues of SRSF1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4667
cellular location: GO:0005654
comment: Reactome DB_ID: 3653933
comment: Converted from EntitySet in Reactome

UnificationXref483
type: UnificationXref
id: 3656446
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656446

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IJI0
data source: Provenance1
name: Splicing factor, arginine/serine-rich 1
name: Q8IJI0
name: Splicing factor, arginine/serine-rich 1 (pre-mRNA splicing factor SF2, P33 subunit) (Alternative splicing factor ASF-1)
name: Alternative splicing factor ASF-1
name: pre-mRNA splicing factor SF2, P33 subunit
name: SF2/ASF/SFRS1
xref: UnificationXref4664
feature: FragmentFeature902
cellular location: GO:0005654
comment: Reactome DB_ID: 3653928
display name: SRSF1

UnificationXref482
type: UnificationXref
id: 3656445
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656445

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I0W7
data source: Provenance1
name: U5-100 kDa protein
name: Q8I0W7
xref: UnificationXref4656
feature: FragmentFeature900
cellular location: GO:0005654
comment: Reactome DB_ID: 3653973
display name: DDX23

UnificationXref481
type: UnificationXref
id: REACT_111412
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111412.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I3Q7
data source: Provenance1
name: Sm-like protein LSm2
name: U6 snRNA-associated Sm-like protein LSm2
name: Q8I3Q7
name: LSM2
name: SnRNP core SM-like protein SM-x5
name: Small nuclear ribonuclear protein D homolog
xref: UnificationXref4657
feature: FragmentFeature901
cellular location: GO:0005654
comment: Reactome DB_ID: 3653993
display name: G7b

UnificationXref480
type: UnificationXref
id: 1454919
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1454919

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IJZ9
data source: Provenance1
name: 116 kDa U5 small nuclear ribonucleoprotein component (U5 snRNP- specific protein, 116 kDa) (U5-116 kDa)
name: U5 snRNP- specific protein, 116 kDa
name: Q8IJZ9
name: U5S1_HUMAN
name: U5-116 kDa protein
name: U5-116 kDa
name: 116 kDa U5 small nuclear ribonucleoprotein component
xref: UnificationXref4652
feature: FragmentFeature898
cellular location: GO:0005654
comment: Reactome DB_ID: 3653981
display name: EFTUD2

Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence829
EC number: 4.6.1.1
xref: UnificationXref6029
xref: UnificationXref6028
left: SmallMolecule16
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule18
right: SmallMolecule17

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IFP1
data source: Provenance1
name: U5-200kDa helicase
name: U520_HUMAN
name: SNRNP200
name: U5 small nuclear ribonucleoprotein 200 kDa helicase
name: U5-200KD
name: U5 snRNP-specific 200 kDa protein
xref: UnificationXref4654
feature: FragmentFeature899
cellular location: GO:0005654
comment: Reactome DB_ID: 3653985
display name: Q8IFP1

http://identifiers.org/pubmed/11331907
type: PublicationXref
id: 11331907
author: Irvine, RF
author: Schell, MJ
db: Pubmed
title: Back in the water: the return of the inositol phosphates
source: Nat Rev Mol Cell Biol 2:327-38
year: 2001

Signalling to RAS
type: Pathway
data source: Provenance1
pathway component: REACT 157443.3
evidence: Evidence811
xref: UnificationXref5993
xref: RelationshipXref646
xref: UnificationXref5992
pathway order: PathwayStep16
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

N-linked glycosylation of WNTs
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence843
xref: UnificationXref6060
xref: UnificationXref6061
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

WNT ligands traffic to the Golgi
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence844
xref: UnificationXref6062
xref: UnificationXref6063
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

cAMP degradation by Phosphodiesterases
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence830
xref: UnificationXref6031
xref: UnificationXref6030
left: SmallMolecule11
left: SmallMolecule17
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule138

Inactive catalytic PP2B is activated by the binding of calmodulin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence838
xref: UnificationXref6050
xref: UnificationXref6051
left: Active Calmodulin (name copied from entity in Homo sapiens)
left: Complex389
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex390

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I5G8
data source: Provenance1
name: Pre-mRNA branch site protein p14
name: Hypothetical protein CGI-110 (Protein HSPC175)
name: SF3B14
name: CGI-110
name: Q8I5G8
name: HSPC175
name: p14 branch site protein
xref: UnificationXref4671
feature: FragmentFeature904
cellular location: GO:0005654
comment: Reactome DB_ID: 3653958
display name: Ht006

SAP 155
type: Protein
entity reference: O77327
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Splicing factor 3B subunit 1
name: Splicing factor 3B subunit 1 (Spliceosome associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA splicing factor SF3b 155 kDa subunit)
name: Spliceosome associated protein 155
name: Pre-mRNA splicing factor SF3b 155 kDa subunit
name: SAP155
name: O77327
name: SF3b155
xref: UnificationXref4673
feature: FragmentFeature905
cellular location: GO:0005654
comment: Reactome DB_ID: 3653937
display name: SF3B1

UnificationXref479
type: UnificationXref
id: REACT_111889
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111889.1

SAP 49
type: Protein
entity reference: Q8ILQ0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Splicing factor 3B subunit 4 (Spliceosome associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA splicing factor SF3b 49 kDa subunit)
name: Spliceosome associated protein 49
name: Q8ILQ0
name: SF3b50
name: Splicing factor 3B subunit 4
name: SAP49
name: Pre-mRNA splicing factor SF3b 49 kDa subunit
xref: UnificationXref4675
feature: FragmentFeature906
cellular location: GO:0005654
comment: Reactome DB_ID: 3653949
display name: SF3B4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H5I5
data source: Provenance1
name: SF3b5
name: Splicing factor 3B subunit 5
name: C0H5I5
name: Pre-mRNA splicing factor SF3b 10 kDa subunit
xref: UnificationXref4677
feature: FragmentFeature907
cellular location: GO:0005654
comment: Reactome DB_ID: 3653953
display name: SF3B5

UnificationXref476
type: UnificationXref
id: REACT_114417
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114417.8

UnificationXref475
type: UnificationXref
id: 3657501
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657501

UnificationXref478
type: UnificationXref
id: 1454930
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1454930

UnificationXref477
type: UnificationXref
id: CHEBI:25696
db: ChEBI

Ribonucleotide reductase small chain
type: Protein
entity reference: Q9U423
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Ribonucleoside-diphosphate reductase M2 chain
name: Q9U423
xref: UnificationXref4705
feature: FragmentFeature911
cellular location: GO:0005654
comment: Reactome DB_ID: 3656044
display name: RRM2

UnificationXref472
type: UnificationXref
id: 3656416
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656416

Ribonucleotide reductase small chain
type: Protein
entity reference: Q9U428
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Ribonucleoside-diphosphate reductase M2 chain
name: Q9U428
xref: UnificationXref4706
feature: FragmentFeature912
cellular location: GO:0005654
comment: Reactome DB_ID: 3656045
display name: RRM2

UnificationXref471
type: UnificationXref
id: 3656415
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656415

UnificationXref474
type: UnificationXref
id: REACT_98847
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98847.9

UnificationXref473
type: UnificationXref
id: 3656418
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656418

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I574
data source: Provenance1
name: Q8I574
name: SF3b130
name: SAP130
name: STAF130
name: Pre-mRNA splicing factor SF3b 130 kDa subunit
name: Splicing factor 3B subunit 3 (Spliceosome associated protein 130) (SAP 130) (SF3b130) (Pre-mRNA splicing factor SF3b 130 kDa subunit)
name: Splicing factor 3B subunit 3
name: SAP 130
name: Spliceosome associated protein 130
xref: UnificationXref4679
feature: FragmentFeature908
cellular location: GO:0005654
comment: Reactome DB_ID: 3653945
display name: SF3B3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IKL7
data source: Provenance1
name: Splicing factor 3B subunit 2
name: SAP 145
name: SAP 145/ SF3b
name: Spliceosome associated protein 145
name: Q8IKL7
name: SF3b150
name: Pre-mRNA splicing factor SF3b 145 kDa subunit
name: Splicing factor 3B subunit 2 (Spliceosome associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA splicing factor SF3b 145 kDa subunit)
xref: UnificationXref4681
feature: FragmentFeature909
cellular location: GO:0005654
comment: Reactome DB_ID: 3653941
display name: SF3B2

Homologues of RRM2
type: Protein
data source: Provenance1
member physical entity: Ribonucleotide reductase small chain
xref: UnificationXref4707
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656046

UnificationXref470
type: UnificationXref
id: 3656414
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656414

Ribonucleotide reductase small chain
type: Protein
entity reference: Q8IM38
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Ribonucleoside-diphosphate reductase M2 chain
name: Q8IM38
xref: UnificationXref4704
feature: FragmentFeature910
cellular location: GO:0005654
comment: Reactome DB_ID: 3656043
display name: RRM2

Production of AA by iPLA2 upon FCGR activation
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence784
EC number: 3
xref: UnificationXref5900
xref: UnificationXref5901
left: SmallMolecule11
left: SmallMolecule597
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule599
right: SmallMolecule598

UniProt:Q9GTX1
type: ProteinReference
xref: UnificationXref2739
organism: BioSource1

Activation of Calcineurin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence790
xref: UnificationXref5926
xref: UnificationXref5927
participant stoichiometry: Stoichiometry1094
left: SmallMolecule15
left: Active Calmodulin (name copied from entity in Homo sapiens)
left: Complex377
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex379

Translocation of CaN:CaM:NFAT to nucleus
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence791
xref: UnificationXref5952
xref: UnificationXref5953
left: Complex382
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex383

Endosome acidification
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence808
xref: UnificationXref5986
xref: UnificationXref5987
left: SmallMolecule1
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule69

Proteasomal cleavage of substrate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence772
xref: UnificationXref5839
xref: UnificationXref5838
left: PhysicalEntity162
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule583
right: PhysicalEntity160
right: PhysicalEntity123

Proteasomal clevage of exogenous antigen
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence774
xref: UnificationXref5845
xref: UnificationXref5844
left: PhysicalEntity163
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule583
right: PhysicalEntity161

AGER-1,2,3 bind AGEs
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence779
xref: UnificationXref5870
xref: UnificationXref5869
left: Protein1404
left: Complex374
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex375

DDX41 binds dsDNA or c-di-NMP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence781
xref: UnificationXref5889
xref: UnificationXref5888
left: Protein1405
left: SmallMolecule594
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex376

Proteasomal cleavage of substrate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence770
xref: UnificationXref5833
xref: UnificationXref5832
left: PhysicalEntity159
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule583
right: PhysicalEntity161
right: PhysicalEntity160
right: PhysicalEntity123

http://identifiers.org/pubmed/21554866
type: PublicationXref
id: 21554866
author: Cox, Brian J
author: Biechele, Steffen
author: Rossant, Janet
db: Pubmed
title: Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos
source: Dev. Biol. 355:275-85
year: 2011

UnificationXref495
type: UnificationXref
id: 3656458
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656458

UnificationXref496
type: UnificationXref
id: 3656459
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656459

UnificationXref493
type: UnificationXref
id: 3656456
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656456

UnificationXref494
type: UnificationXref
id: 3656457
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656457

UnificationXref491
type: UnificationXref
id: 3656454
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656454

UnificationXref492
type: UnificationXref
id: 3656455
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656455

UnificationXref490
type: UnificationXref
id: 3656453
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656453

UnificationXref499
type: UnificationXref
id: 3656462
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656462

UnificationXref497
type: UnificationXref
id: 3656460
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656460

UnificationXref498
type: UnificationXref
id: 3656461
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656461

PublicationXref898
type: PublicationXref
author: Parkinson, A
title: Casarett and Doull's Toxicology 5th Edn
source: 113-186
year: 1995

http://identifiers.org/pubmed/19359157
type: PublicationXref
id: 19359157
author: Lykke-Andersen, J
author: Rebbapragada, I
db: Pubmed
title: Execution of nonsense-mediated mRNA decay: what defines a substrate?
source: Curr Opin Cell Biol 21:394-402
year: 2009

http://identifiers.org/pubmed/17698287
type: PublicationXref
id: 17698287
author: Grabowska, AM
author: Watson, SA
db: Pubmed
title: Role of gastrin peptides in carcinogenesis
source: Cancer Lett 257:1-15
year: 2007

http://identifiers.org/pubmed/7378348
type: PublicationXref
id: 7378348
author: So, AG
author: Tan, CK
author: Downey, KM
author: Lee, MY
db: Pubmed
title: Purification of deoxyribonucleic acid polymerase delta from calf thymus: partial characterization of physical properties.
source: Biochemistry 19:2096-101
year: 1980

PublicationXref873
type: PublicationXref
author: Oesch, F
author: Arand, M
title: Toxicology
source: 83-107
year: 1999

http://identifiers.org/pubmed/8089153
type: PublicationXref
id: 8089153
author: Hirst, M
author: Lou, L
author: Nakamura, J
author: Haliday, E
db: Pubmed
title: Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA
source: J Biol Chem 269:23830-23837
year: 1994

TCR signaling
type: Pathway
data source: Provenance1
pathway component: Generation of second messenger molecules
evidence: Evidence766
xref: UnificationXref5793
xref: RelationshipXref632
xref: UnificationXref5794
pathway order: PathwayStep740
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11425315
type: PublicationXref
id: 11425315
author: Peng, H
author: Liu, Q
author: Golde, DW
author: Vera, JC
db: Pubmed
title: The predicted ATP-binding domains in the hexose transporter GLUT1 critically affect transporter activity.
source: Biochemistry 40:7874-81
year: 2001

http://identifiers.org/pubmed/22522127
type: PublicationXref
id: 22522127
author: Oakley, Aaron J
author: Brock, Joseph
author: Liu, D
author: Board, PG
author: Zhou, Huina
db: Pubmed
title: Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases
source: J. Mol. Biol. 420:190-203
year: 2012

http://identifiers.org/pubmed/14729598
type: PublicationXref
id: 14729598
author: Zhou, B
author: Shao, J
author: Zhu, L
author: Yen, Y
author: Qiu, W
author: Xi, B
author: Yuan, YC
db: Pubmed
title: In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase
source: Cancer Res 64:1-6
year: 2004

http://identifiers.org/pubmed/17635743
type: PublicationXref
id: 17635743
author: Bluteau, D
author: Debili, N
author: Chang, Y
author: Vainchenker, W
db: Pubmed
title: From hematopoietic stem cells to platelets
source: J Thromb Haemost 5:318-27
year: 2007

Pyruvate
type: SmallMoleculeReference
name: Pyruvic acid
name: Pyroracemic acid
name: 2-Oxopropanoate
name: 2-Oxopropanoic acid
name: Pyruvate [ChEBI:32816]
xref: UnificationXref2420

PublicationXref825
type: PublicationXref
id: 0079130356
author: Goodman, SI
author: Frerman, FE
db: ISBN
title: Organic acidemias due to defects in lysine oxidation: 2-ketoadipic acidemia and glutaric acidemia
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 2195-2204
year: 2001

PublicationXref823
type: PublicationXref
id: 0079130356
author: Cox, RP
db: ISBN
title: Errors of lysine metabolism
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 1965-1970
year: 2001

PublicationXref821
type: PublicationXref
id: 0079130356
author: Williams, JC
author: Sweetman, L
db: ISBN
title: Branched chain organic acidurias
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 2125-2163
year: 2001

Synthesis of DNA
type: Pathway
data source: Provenance1
pathway component: DNA strand elongation
pathway component: Switching of origins to a post-replicative state
pathway component: REACT 102345.9
evidence: Evidence607
xref: UnificationXref5020
xref: UnificationXref5021
pathway order: PathwayStep590
pathway order: PathwayStep572
pathway order: PathwayStep578
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Cori Cycle (interconversion of glucose and lactate)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction151
evidence: Evidence302
xref: RelationshipXref285
xref: UnificationXref2433
xref: UnificationXref2432
pathway order: PathwayStep296
display name: Pyruvate metabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:Q9BMP5
type: ProteinReference
xref: UnificationXref2002
organism: BioSource1

http://identifiers.org/pubmed/16807922
type: PublicationXref
id: 16807922
author: Hu, WS
author: Lee, MM
author: Hossler, P
author: Goh, LT
db: Pubmed
title: GlycoVis: visualizing glycan distribution in the protein N-glycosylation pathway in mammalian cells
source: Biotechnol Bioeng 95:946-60
year: 2006

PublicationXref834
type: PublicationXref
id: 0079130356
author: Horwich, AL
author: Brusilow, SW
db: ISBN
title: Urea cycle enzymes
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 1909-1963
year: 2001

http://identifiers.org/pubmed/10227690
type: PublicationXref
id: 10227690
author: Klepper, J
author: De Vivo, DC
author: O'Driscoll, KR
author: Fischbarg, J
author: Jarjour, IT
author: Wang, D
author: Vera, JC
db: Pubmed
title: Defective glucose transport across brain tissue barriers: a newly recognized neurological syndrome
source: Neurochem Res 24:587-94
year: 1999

http://identifiers.org/pubmed/8428657
type: PublicationXref
id: 8428657
author: Yang, DC
author: Donovan, D
author: Vogeli, G
author: Vilalta, A
author: Wood, L
db: Pubmed
title: Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase
source: Gene 123:181-6
year: 1993

Processive synthesis on the lagging strand
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction315
evidence: Evidence604
xref: UnificationXref5014
xref: UnificationXref5015
pathway order: PathwayStep587
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

ChEBI:53014 N(6)-carboxymethyl-L-lysine
type: SmallMoleculeReference
name: N(6)-carboxymethyl-L-lysine
xref: UnificationXref5854

http://identifiers.org/pubmed/17222174
type: PublicationXref
id: 17222174
author: Van Schaftingen, E
author: Linster, CL
db: Pubmed
title: Vitamin C: biosynthesis, recycling and degradation in mammals
source: FEBS J 274:1-22
year: 2007

M/G1 Transition
type: Pathway
data source: Provenance1
pathway component: DNA Replication Pre-Initiation
evidence: Evidence612
xref: UnificationXref5031
xref: UnificationXref5030
pathway order: PathwayStep595
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/12641448
type: PublicationXref
id: 12641448
author: Tatham, Michael H
author: Chen, Yuan
author: Hay, Ronald T
db: Pubmed
title: Role of two residues proximal to the active site of Ubc9 in substrate recognition by the Ubc9.SUMO-1 thiolester complex
source: Biochemistry 42:3168-79
year: 2003

Glutathione synthesis and recycling
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction230
evidence: Evidence415
xref: UnificationXref3548
xref: RelationshipXref447
xref: UnificationXref3547
pathway order: PathwayStep409
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/18767960
type: PublicationXref
id: 18767960
author: Antonellis, A
author: Green, ED
db: Pubmed
title: The role of aminoacyl-tRNA synthetases in genetic diseases
source: Annu Rev Genomics Hum Genet 9:87-107
year: 2008

http://identifiers.org/pubmed/2995985
type: PublicationXref
id: 2995985
author: Evans, DR
author: Kelly, RE
author: Pastra-Landis, SC
author: Lee, L
db: Pubmed
title: Oligomeric structure of the multifunctional protein CAD that initiates pyrimidine biosynthesis in mammalian cells
source: Proc Natl Acad Sci USA 82:6802-6806
year: 1985

UniProt:Q2V2M6
type: ProteinReference
xref: UnificationXref5582
organism: BioSource1

http://identifiers.org/pubmed/18201392
type: PublicationXref
id: 18201392
author: Clarke, LA
db: Pubmed
title: The mucopolysaccharidoses: a success of molecular medicine
source: Expert Rev Mol Med 10:e1
year: 2008

UniProt:B9ZSI8
type: ProteinReference
xref: UnificationXref4229
organism: BioSource1

6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositols
type: SmallMoleculeReference
name: 6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol [ChEBI:53059]
name: 6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol
xref: UnificationXref4210

(GlcN)1 (Ino(acyl)-P)1 (Man)2 (EtN)1 (P)1
type: SmallMoleculeReference
xref: UnificationXref4200

http://identifiers.org/pubmed/1335363
type: PublicationXref
id: 1335363
author: Birnbaumer, L
db: Pubmed
title: Receptor-to-effector signaling through G proteins: roles for beta gamma dimers as well as alpha subunits
source: Cell 71:1069-72
year: 1992

http://identifiers.org/pubmed/11706405
type: PublicationXref
id: 11706405
author: Tari, AM
author: Lopez-Berestein, G
db: Pubmed
title: GRB2: a pivotal protein in signal transduction
source: Semin Oncol 28:142-7
year: 2001

http://identifiers.org/pubmed/9305914
type: PublicationXref
id: 9305914
author: Ishimi, Y
db: Pubmed
title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
source: J Biol Chem 272:24508-13
year: 1997

http://identifiers.org/pubmed/15314182
type: PublicationXref
id: 15314182
author: Bedwell, DM
author: Salas-Marco, J
db: Pubmed
title: GTP hydrolysis by eRF3 facilitates stop codon decoding during eukaryotic translation termination
source: Mol Cell Biol 24:7769-78
year: 2004

Switching of origins to a post-replicative state
type: Pathway
data source: Provenance1
pathway component: REACT 93416.9
pathway component: BiochemicalReaction309
evidence: Evidence594
xref: UnificationXref4950
xref: UnificationXref4949
pathway order: PathwayStep577
pathway order: PathwayStep576
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/8114698
type: PublicationXref
id: 8114698
author: Nevins, JR
author: Ohtani, K
db: Pubmed
title: Functional properties of a Drosophila homolog of the E2F1 gene
source: Mol Cell Biol 14:1603-12
year: 1994

UniProt:Q9BMH1
type: ProteinReference
xref: UnificationXref2069
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O97227
data source: Provenance1
name: dihydrolipoamide branched chain transacylase E2
name: O97227
name: Lipo-DBT
xref: UnificationXref3263
feature: FragmentFeature627
feature: ModificationFeature34
cellular location: GO:0005759
comment: Reactome DB_ID: 3652962
display name: DBT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O77330
data source: Provenance1
name: Glutamine- dependent asparagine synthetase
name: TS11 cell cycle control protein
name: O77330
name: ASNS(2-561)
name: Asparagine synthetase (glutamine-hydrolyzing)
xref: UnificationXref3234
feature: FragmentFeature626
cellular location: GO:0005829
comment: Reactome DB_ID: 3652915
display name: ASNS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q27722
data source: Provenance1
name: Q27722
name: pyrroline-5-carboxylate reductase 1
name: P5C reductase
xref: UnificationXref3225
feature: FragmentFeature625
cellular location: GO:0005759
comment: Reactome DB_ID: 3652932
display name: PYCR1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8IDC6
data source: Provenance1
name: pyrroline-5-carboxylate reductase 1
name: P5C reductase
name: Q8IDC6
xref: UnificationXref3223
feature: FragmentFeature624
cellular location: GO:0005759
comment: Reactome DB_ID: 3652930
display name: PYCR1

Homologues of CPS1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3310
cellular location: GO:0005759
comment: Reactome DB_ID: 3652887
comment: Converted from EntitySet in Reactome

Signalling to p38 via RIT and RIN
type: Pathway
data source: Provenance1
pathway component: REACT 157443.3
evidence: Evidence812
xref: UnificationXref5995
xref: RelationshipXref647
xref: UnificationXref5994
pathway order: PathwayStep16
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref109
type: UnificationXref
id: REACT_12371
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_12371.4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I523
data source: Provenance1
name: HIBCH(32-386)
name: 3-hydroxyisobutyryl-coenzyme A hydrolase
xref: UnificationXref3287
feature: FragmentFeature630
cellular location: GO:0005759
comment: Reactome DB_ID: 3652976
display name: Q8I523

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I0X1
data source: Provenance1
name: Q8I0X1
name: branched chain keto acid dehydrogenase E1, beta polypeptide
xref: UnificationXref3267
feature: FragmentFeature629
cellular location: GO:0005759
comment: Reactome DB_ID: 3652945
display name: BCKDHB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IEJ6
data source: Provenance1
name: Q8IEJ6
name: branched chain keto acid dehydrogenase E1, alpha polypeptide
xref: UnificationXref3265
feature: FragmentFeature628
cellular location: GO:0005759
comment: Reactome DB_ID: 3652941
display name: BCKDHA

UnificationXref1759
type: UnificationXref
id: 75967
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=75967

UnificationXref1756
type: UnificationXref
id: 3654094
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654094

Homologues of PYCR1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3226
cellular location: GO:0005759
comment: Reactome DB_ID: 3652933
comment: Converted from EntitySet in Reactome

UnificationXref1755
type: UnificationXref
id: 3654092
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654092

UnificationXref1758
type: UnificationXref
id: CHEBI:37554
db: ChEBI

UnificationXref1757
type: UnificationXref
id: REACT_93763
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93763.9

UnificationXref1762
type: UnificationXref
id: 549167
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=549167

UnificationXref1763
type: UnificationXref
id: REACT_22886
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22886.2

UnificationXref110
type: UnificationXref
id: CHEBI:18035
db: ChEBI

UnificationXref1764
type: UnificationXref
id: O97295
db: UniProt

UnificationXref111
type: UnificationXref
id: 112275
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=112275

UnificationXref1765
type: UnificationXref
id: 3654098
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654098

http://identifiers.org/pubmed/803528
type: PublicationXref
id: 803528
author: Winchester, RJ
author: Fu, SM
author: Kunkel, HG
db: Pubmed
title: Similar idiotypic specificity for the membrane IgD and IgM of human B lymphocytes
source: J Immunol 114:250-2
year: 1975

UnificationXref1760
type: UnificationXref
id: REACT_5036
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5036.4

UnificationXref1761
type: UnificationXref
id: CHEBI:17855
db: ChEBI

UnificationXref116
type: UnificationXref
id: Q8IJR0
db: UniProt

UnificationXref117
type: UnificationXref
id: MOD:00048
db: MOD

UnificationXref118
type: UnificationXref
id: 3654595
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654595

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8IBI5
data source: Provenance1
name: Q8IBI5
name: NSF1 isoform 2
xref: UnificationXref3190
feature: FragmentFeature622
cellular location: GO:0005829
comment: Reactome DB_ID: 3656264
display name: NFS1-2

UnificationXref119
type: UnificationXref
id: 3654597
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654597

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6LFH8
data source: Provenance1
name: ornithine-oxo-acid aminotransferase
name: PXLP-OAT(26-439)
name: Q6LFH8
name: ornithine aminotransferase, mitochondrial
xref: UnificationXref3210
feature: FragmentFeature623
feature: ModificationFeature33
cellular location: GO:0005759
comment: Reactome DB_ID: 3652923
display name: OAT

UnificationXref112
type: UnificationXref
id: REACT_12312
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_12312.3

UnificationXref113
type: UnificationXref
id: CHEBI:16595
db: ChEBI

UnificationXref114
type: UnificationXref
id: 114520
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114520

UnificationXref115
type: UnificationXref
id: REACT_2897
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2897.4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O15804
data source: Provenance1
name: ornithine transcarbamylase
name: O15804
name: ornithine carbamoyltransferase, mitochondrial
xref: UnificationXref3324
feature: FragmentFeature634
cellular location: GO:0005759
comment: Reactome DB_ID: 3652897
display name: OTC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IDP8
data source: Provenance1
name: ornithine transcarbamylase
name: Q8IDP8
name: ornithine carbamoyltransferase, mitochondrial
xref: UnificationXref3322
feature: FragmentFeature633
cellular location: GO:0005759
comment: Reactome DB_ID: 3652895
display name: OTC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I384
data source: Provenance1
name: arginase 1
name: Q8I384
name: liver-type arginase
name: Arginase 1
xref: UnificationXref3338
feature: FragmentFeature635
cellular location: GO:0005829
comment: Reactome DB_ID: 3652905
display name: ARG1

Homologues of ARG1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3341
cellular location: GO:0005829
comment: Reactome DB_ID: 3652908
comment: Converted from EntitySet in Reactome

Homologues of ARG2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3351
cellular location: GO:0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655981

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8WPZ7
data source: Provenance1
name: arginase 1
name: liver-type arginase
name: Q8WPZ7
name: Arginase 1
xref: UnificationXref3340
feature: FragmentFeature636
cellular location: GO:0005829
comment: Reactome DB_ID: 3652907
display name: ARG1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8WPZ7
data source: Provenance1
name: Arginase-2, mitochondrial
name: Q8WPZ7
xref: UnificationXref3350
feature: FragmentFeature638
cellular location: GO:0005759
comment: Reactome DB_ID: 3655980
display name: ARG2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I384
data source: Provenance1
name: Q8I384
name: Arginase-2, mitochondrial
xref: UnificationXref3349
feature: FragmentFeature637
cellular location: GO:0005759
comment: Reactome DB_ID: 3655979
display name: ARG2

UnificationXref1769
type: UnificationXref
id: 3654102
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654102

Purine metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 83164.9
pathway component: REACT 103526.9
evidence: Evidence320
xref: UnificationXref2636
xref: RelationshipXref312
xref: UnificationXref2637
pathway order: PathwayStep310
pathway order: PathwayStep314
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1768
type: UnificationXref
id: 3654101
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654101

UnificationXref1767
type: UnificationXref
id: 3654100
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654100

Homologues of OTC
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3325
cellular location: GO:0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3652898

UnificationXref1766
type: UnificationXref
id: Q6F492
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q27732
data source: Provenance1
name: Q27732
name: carbamoyl-phosphate synthase (ammonia), mitochondrial
name: carbamoyl-phosphate synthetase I
name: CPSase I
xref: UnificationXref3309
feature: FragmentFeature632
cellular location: GO:0005759
comment: Reactome DB_ID: 3652886
display name: CPS1

UnificationXref121
type: UnificationXref
id: P62203
db: UniProt

UnificationXref1775
type: UnificationXref
id: 3654022
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654022

UnificationXref122
type: UnificationXref
id: 3653800
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653800

UnificationXref1776
type: UnificationXref
id: REACT_129698
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129698.5

UnificationXref1773
type: UnificationXref
id: REACT_82183
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82183.9

UnificationXref120
type: UnificationXref
id: REACT_113618
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113618.8

UnificationXref1774
type: UnificationXref
id: 3654020
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654020

UnificationXref1771
type: UnificationXref
id: REACT_28123
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28123.10

UnificationXref1772
type: UnificationXref
id: 3657270
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657270

http://identifiers.org/pubmed/21068004
type: PublicationXref
id: 21068004
author: Zechner, R
author: Sitnick, MT
author: Cai, L
author: Li, JZ
author: Kershaw, EE
author: Schoiswohl, G
author: Brenner, DS
author: Basantani, MK
author: Kumari, M
author: Gardner, NP
author: Gross, RW
author: Yang, K
db: Pubmed
title: Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome
source: J Lipid Res 52:318-29
year: 2011

UnificationXref1770
type: UnificationXref
id: 3654104
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654104

UnificationXref129
type: UnificationXref
id: 3653804
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653804

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IEN3
data source: Provenance1
name: carbamoyl-phosphate synthase (ammonia), mitochondrial
name: carbamoyl-phosphate synthetase I
name: CPSase I
name: Q8IEN3
xref: UnificationXref3308
feature: FragmentFeature631
cellular location: GO:0005759
comment: Reactome DB_ID: 3652884
display name: CPS1

UnificationXref127
type: UnificationXref
id: 74016
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74016

UnificationXref128
type: UnificationXref
id: REACT_5631
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5631.2

UnificationXref125
type: UnificationXref
id: 3653803
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653803

UnificationXref126
type: UnificationXref
id: CHEBI:29108
db: ChEBI

UnificationXref123
type: UnificationXref
id: P24044
db: UniProt

UnificationXref124
type: UnificationXref
id: 3653802
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653802

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8IAZ8
data source: Provenance1
name: Phosphopantothenoylcysteine decarboxylase
name: Q8IAZ8
name: COAC_HUMAN
xref: UnificationXref3104
feature: FragmentFeature612
cellular location: GO:0005829
comment: Reactome DB_ID: 3654878
display name: PPCDC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U0G7
data source: Provenance1
name: Q9U0G7
name: COAB
name: PPCS_HUMAN
name: Phosphopantothenate-cysteine ligase
xref: UnificationXref3095
feature: FragmentFeature611
cellular location: GO:0005829
comment: Reactome DB_ID: 3654860
display name: PPCS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IIX6
data source: Provenance1
name: COAB
name: Q8IIX6
name: PPCS_HUMAN
name: Phosphopantothenate-cysteine ligase
xref: UnificationXref3093
feature: FragmentFeature610
cellular location: GO:0005829
comment: Reactome DB_ID: 3654856
display name: PPCS

Homologues of PPCS
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3096
cellular location: GO:0005829
comment: Reactome DB_ID: 3654861
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8ILP4
data source: Provenance1
name: Pantothenate kinase 1
name: Q8ILP4
name: PANK1_HUMAN
xref: UnificationXref3082
feature: FragmentFeature609
cellular location: GO:0005829
comment: Reactome DB_ID: 3654964
display name: PANK1

Pantothenate kinase 1;3;4
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3083
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654965
display name: PANK1/3/4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8ILP4
data source: Provenance1
name: PANK2(111-570)
name: Pantothenate kinase 2
name: Q8ILP4
name: PNK2_HUMAN
xref: UnificationXref3079
feature: FragmentFeature608
cellular location: GO:0005758
comment: Reactome DB_ID: 3654885
display name: PANK2

UnificationXref1734
type: UnificationXref
id: REACT_112844
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112844.8

UnificationXref1733
type: UnificationXref
id: 3657268
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657268

UnificationXref1736
type: UnificationXref
id: REACT_84945
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_84945.9

UnificationXref1735
type: UnificationXref
id: 3657269
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657269

UnificationXref1738
type: UnificationXref
id: 76116
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76116

UnificationXref1737
type: UnificationXref
id: CHEBI:17754
db: ChEBI

UnificationXref1739
type: UnificationXref
id: REACT_3756
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3756.1

http://identifiers.org/pubmed/15581364
type: PublicationXref
id: 15581364
author: Zhai, H
author: McLafferty, FW
author: Brand, LA
author: Begley, TP
author: Strauss, E
db: Pubmed
title: Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent
source: Biochemistry 43:15520-33
year: 2004

UnificationXref1740
type: UnificationXref
id: CHEBI:15978
db: ChEBI

UnificationXref1741
type: UnificationXref
id: 76114
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76114

UnificationXref1742
type: UnificationXref
id: REACT_4327
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4327.2

UnificationXref1743
type: UnificationXref
id: Q8IDI4
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I2X3
data source: Provenance1
name: Q8I2X3
name: PPA5_HUMAN
name: Tartrate-resistant acid phosphatase type 5
xref: UnificationXref3062
feature: FragmentFeature606
cellular location: GO:0005829
comment: Reactome DB_ID: 3654897
display name: ACP5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0MHL8
data source: Provenance1
name: C0MHL8
name: PPA5_HUMAN
name: Tartrate-resistant acid phosphatase type 5
xref: UnificationXref3064
feature: FragmentFeature607
cellular location: GO:0005829
comment: Reactome DB_ID: 3654899
display name: ACP5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IJP5
data source: Provenance1
name: Q8NFF5_HUMAN
name: Q8IJP5
name: FAD1 flavin adenine dinucleotide synthetase homolog
xref: UnificationXref3058
feature: FragmentFeature605
cellular location: GO:0005829
comment: Reactome DB_ID: 3654891
display name: FLAD1

Homologues of ACP5
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3065
cellular location: GO:0005829
comment: Reactome DB_ID: 3654900
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IE69
data source: Provenance1
name: Folylpolyglutamate synthase-1
name: Q8IE69
name: FOLC_HUMAN
xref: UnificationXref3174
feature: FragmentFeature619
cellular location: GO:0005759
comment: Reactome DB_ID: 3655033
display name: FPGS-1

Q9U738
type: Protein
entity reference: Q9U738
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Folylpolyglutamate synthase-1
name: FOLC_HUMAN
xref: UnificationXref3173
feature: FragmentFeature618
cellular location: GO:0005759
comment: Reactome DB_ID: 3655032
display name: FPGS-1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8ID54
data source: Provenance1
name: CysS-MOCS3
name: MOCS3-S-S(1-)
xref: UnificationXref3184
feature: ModificationFeature32
feature: FragmentFeature621
cellular location: GO:0005829
comment: Reactome DB_ID: 3656259
display name: Q8ID54

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8ID54
data source: Provenance1
name: MOCS3 (red.)
name: Q8ID54
xref: UnificationXref3181
feature: FragmentFeature620
cellular location: GO:0005829
comment: Reactome DB_ID: 3656256
display name: MOCS3

Q9U738
type: Protein
entity reference: Q9U738
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Folylpolyglutamate synthase-2
name: FPGS isoform 2
name: FOLC_HUMAN
xref: UnificationXref3153
feature: FragmentFeature616
cellular location: GO:0005829
comment: Reactome DB_ID: 3654929
display name: FPGS-2

Homologues of FPGS-2
type: Protein
data source: Provenance1
member physical entity: Q9U738
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3156
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654932

Homologues of FPGS-1
type: Protein
data source: Provenance1
member physical entity: Q9U738
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3175
cellular location: GO:0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655034

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IE69
data source: Provenance1
name: Folylpolyglutamate synthase-2
name: FPGS isoform 2
name: Q8IE69
name: FOLC_HUMAN
xref: UnificationXref3155
feature: FragmentFeature617
cellular location: GO:0005829
comment: Reactome DB_ID: 3654931
display name: FPGS-2

UnificationXref1747
type: UnificationXref
id: CHEBI:29089
db: ChEBI

UnificationXref1746
type: UnificationXref
id: REACT_149613
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149613.4

UnificationXref1745
type: UnificationXref
id: 3654086
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654086

UnificationXref1744
type: UnificationXref
id: 3654084
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654084

UnificationXref1749
type: UnificationXref
id: REACT_3539
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3539.3

UnificationXref1748
type: UnificationXref
id: 76108
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76108

UnificationXref1750
type: UnificationXref
id: 76103
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76103

http://identifiers.org/pubmed/10522552
type: PublicationXref
id: 10522552
author: Ponka, P
db: Pubmed
title: Cell biology of heme
source: Am J Med Sci 318:241-56
year: 1999

UnificationXref1753
type: UnificationXref
id: 3654090
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654090

UnificationXref100
type: UnificationXref
id: REACT_139946
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139946.5

UnificationXref1754
type: UnificationXref
id: 3654091
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654091

UnificationXref1751
type: UnificationXref
id: REACT_4481
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4481.3

UnificationXref1752
type: UnificationXref
id: O77317
db: UniProt

UnificationXref103
type: UnificationXref
id: CHEBI:15377
db: ChEBI

UnificationXref104
type: UnificationXref
id: 29356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356

UnificationXref101
type: UnificationXref
id: 3657447
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657447

UnificationXref102
type: UnificationXref
id: REACT_144588
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144588.5

UnificationXref107
type: UnificationXref
id: CHEBI:18348
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H5F8
data source: Provenance1
name: Probable lysosomal cobalamin transporter
name: LMBD1_HUMAN
name: C0H5F8
xref: UnificationXref3120
feature: FragmentFeature613
cellular location: GO:0005765
comment: Reactome DB_ID: 3657123
display name: LMBRD1

UnificationXref108
type: UnificationXref
id: 179856
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179856

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I2P2
data source: Provenance1
name: NADSYN1
name: NADE1_HUMAN
name: Glutamine-dependent NAD(+) synthetase
xref: UnificationXref3129
feature: FragmentFeature614
cellular location: GO:0005829
comment: Reactome DB_ID: 3654922
display name: Q8I2P2

UnificationXref105
type: UnificationXref
id: REACT_3683
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3683.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C6KTC6
data source: Provenance1
name: Nicotinate phosphoribosyltransferase
name: C6KTC6
xref: UnificationXref3140
feature: FragmentFeature615
cellular location: GO:0005829
comment: Reactome DB_ID: 3654914
display name: NAPRT1

UnificationXref106
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

UnificationXref1799
type: UnificationXref
id: CHEBI:16238
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8IBP3
data source: Provenance1
name: Q8IBP3
name: Inosine triphosphate pyrophosphatase
xref: UnificationXref2981
feature: FragmentFeature600
cellular location: GO:0005829
comment: Reactome DB_ID: 3657017
display name: ITPA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I599
data source: Provenance1
name: CYB5A (membrane-bound)
name: Q8I599
name: Cytochrome b5
xref: UnificationXref3012
feature: FragmentFeature601
cellular location: GO:0005741
comment: Reactome DB_ID: 3654959
display name: CYB5A

Homologues of TPK1
type: Protein
data source: Provenance1
member physical entity: Q14RW4
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3041
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654871

Q14RW4
type: Protein
entity reference: UniProt:Q14RW4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: TPK1_HUMAN
name: Thiamin pyrophosphokinase 1
xref: UnificationXref3038
feature: FragmentFeature602
cellular location: GO:0005829
comment: Reactome DB_ID: 3654868
display name: TPK1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H556
data source: Provenance1
name: C0H556
name: TPK1_HUMAN
name: Thiamin pyrophosphokinase 1
xref: UnificationXref3040
feature: FragmentFeature603
cellular location: GO:0005829
comment: Reactome DB_ID: 3654870
display name: TPK1

Riboflavin kinase
type: Protein
entity reference: UniProt:Q8IDB3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: RIFK_HUMAN
name: Q8IDB3
name: RFK(1-162)
xref: UnificationXref3053
feature: FragmentFeature604
cellular location: GO:0005829
comment: Reactome DB_ID: 3654907
display name: RFK

UnificationXref1777
type: UnificationXref
id: 3657267
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657267

UnificationXref1778
type: UnificationXref
id: REACT_141406
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141406.5

UnificationXref1779
type: UnificationXref
id: 113559
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113559

2'-deoxyinosine
type: SmallMoleculeReference
name: deoxyinosine
name: 2'-deoxyinosine [ChEBI:28997]
xref: UnificationXref2585

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction150
evidence: Evidence298
xref: UnificationXref2415
xref: UnificationXref2414
pathway order: PathwayStep292
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1781
type: UnificationXref
id: CHEBI:15345
db: ChEBI

UnificationXref1780
type: UnificationXref
id: REACT_3839
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3839.2

UnificationXref1783
type: UnificationXref
id: REACT_2705
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2705.2

UnificationXref1782
type: UnificationXref
id: 73871
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73871

UnificationXref1785
type: UnificationXref
id: REACT_3654
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3654.2

UnificationXref1784
type: UnificationXref
id: 29374
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29374

UnificationXref1787
type: UnificationXref
id: 3652969
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652969

UnificationXref1786
type: UnificationXref
id: Q8IKW7
db: UniProt

SequenceSite403
type: SequenceSite
position status: EQUAL
sequence position: 652

SequenceSite402
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite405
type: SequenceSite
position status: EQUAL
sequence position: 652

UnificationXref1788
type: UnificationXref
id: 3652970
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652970

SequenceSite404
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1789
type: UnificationXref
id: 3653776
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653776

SequenceSite407
type: SequenceSite
position status: EQUAL
sequence position: 501

SequenceSite406
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite409
type: SequenceSite
position status: EQUAL
sequence position: 501

SequenceSite408
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9191022
type: PublicationXref
id: 9191022
author: Hindges, R
author: Hubscher, U
db: Pubmed
title: DNA polymerase delta, an essential enzyme for DNA transactions.
source: Biol Chem 378:345-62
year: 1997

SequenceSite401
type: SequenceSite
position status: EQUAL
sequence position: 679

http://identifiers.org/pubmed/7706277
type: PublicationXref
id: 7706277
author: Lou, L
author: Nakamura, J
db: Pubmed
title: Biochemical characterization of human GMP synthetase
source: J Biol Chem 270:7347-7353
year: 1995

SequenceSite400
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1790
type: UnificationXref
id: REACT_82468
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82468.9

UnificationXref1794
type: UnificationXref
id: REACT_28462
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28462.10

UnificationXref1793
type: UnificationXref
id: 3653777
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653777

UnificationXref1792
type: UnificationXref
id: REACT_86263
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86263.9

UnificationXref1791
type: UnificationXref
id: 3657214
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657214

UnificationXref1798
type: UnificationXref
id: REACT_31341
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31341.10

UnificationXref1797
type: UnificationXref
id: 3657215
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657215

UnificationXref1796
type: UnificationXref
id: REACT_81278
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81278.9

UnificationXref1795
type: UnificationXref
id: 3657218
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657218

SequenceSite410
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite411
type: SequenceSite
position status: EQUAL
sequence position: 492

SequenceSite412
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite417
type: SequenceSite
position status: EQUAL
sequence position: 496

SequenceSite418
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite419
type: SequenceSite
position status: EQUAL
sequence position: 917

SequenceSite413
type: SequenceSite
position status: EQUAL
sequence position: 492

SequenceSite414
type: SequenceSite
position status: EQUAL
sequence position: 1

Resolution of AP sites via the multiple-nucleotide patch replacement pathway
type: Pathway
data source: Provenance1
pathway component: REACT 95848.9
evidence: Evidence673
xref: UnificationXref5252
xref: UnificationXref5253
pathway order: PathwayStep653
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite415
type: SequenceSite
position status: EQUAL
sequence position: 496

SequenceSite416
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/10958673
type: PublicationXref
id: 10958673
author: Yoshida, H
author: Haze, K
author: Yura, T
author: Yanagi, H
author: Mori, K
author: Okada, T
author: Negishi, M
db: Pubmed
title: ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
source: Mol Cell Biol 20:6755-67
year: 2000

http://identifiers.org/pubmed/19935646
type: PublicationXref
id: 19935646
author: Jang, HG
author: Dang, L
author: Keenan, MC
author: Vander Heiden, MG
author: Bennett, BD
author: Rabinowitz, JD
author: Driggers, EM
author: Gross, S
author: Ward, PS
author: Fantin, VR
author: Thompson, CB
author: Cantley, LC
author: Marks, KM
author: White, DW
author: Bittinger, MA
author: Prins, RM
author: Su, SM
author: Yen, KE
author: Liau, LM
author: Jin, S
db: Pubmed
title: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
source: Nature 462:739-44
year: 2009

SequenceSite422
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite423
type: SequenceSite
position status: EQUAL
sequence position: 465

SequenceSite420
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite421
type: SequenceSite
position status: EQUAL
sequence position: 923

SequenceSite428
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite429
type: SequenceSite
position status: EQUAL
sequence position: 540

SequenceSite426
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite427
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite424
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite425
type: SequenceSite
position status: EQUAL
sequence position: 512

http://identifiers.org/pubmed/9380723
type: PublicationXref
id: 9380723
author: Rock, KL
author: Goldberg, A
author: Akopian, T
author: Craiu, A
db: Pubmed
title: Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide
source: Proc Natl Acad Sci U S A 94:10850-5
year: 1997

SequenceSite430
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite431
type: SequenceSite
position status: EQUAL
sequence position: 540

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O97223
data source: Provenance1
name: eIF4AII
name: O97223
name: eIF4A-II
name: eukaryotic initiation factor 4A-II
name: eIF-4A-II
name: Eukaryotic initiation factor 4A-II
xref: UnificationXref3664
feature: FragmentFeature674
cellular location: GO:0005829
comment: Reactome DB_ID: 3653352
display name: EIF4A2

SequenceSite432
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IKF0
data source: Provenance1
name: eIF4AII
name: Q8IKF0
name: eIF4A-II
name: eukaryotic initiation factor 4A-II
name: eIF-4A-II
name: Eukaryotic initiation factor 4A-II
xref: UnificationXref3662
feature: FragmentFeature673
cellular location: GO:0005829
comment: Reactome DB_ID: 3653351
display name: EIF4A2

SequenceSite433
type: SequenceSite
position status: EQUAL
sequence position: 568

SequenceSite434
type: SequenceSite
position status: EQUAL
sequence position: 1

Homologues of EIF4A1(1-406)
type: Protein
data source: Provenance1
member physical entity: eIF-4A-I
xref: UnificationXref3669
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3653349

SequenceSite435
type: SequenceSite
position status: EQUAL
sequence position: 323

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C6S3D8
data source: Provenance1
name: Meiotic recombination protein SPO11
name: C6S3D8
name: SPO11_HUMAN
xref: UnificationXref3641
feature: FragmentFeature671
cellular location: GO:0005654
comment: Reactome DB_ID: 3656186
display name: SPO11

SequenceSite436
type: SequenceSite
position status: EQUAL
sequence position: 1

phospho-p-PLCG2
type: Protein
entity reference: Q8IJR0
data source: Provenance1
xref: UnificationXref3633
feature: FragmentFeature670
feature: ModificationFeature37
cellular location: GO:0005886
comment: Reactome DB_ID: 3654408

SequenceSite437
type: SequenceSite
position status: EQUAL
sequence position: 323

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q2PZH3
data source: Provenance1
name: eIF4AII
name: eIF4A-II
name: Q2PZH3
name: eukaryotic initiation factor 4A-II
name: eIF-4A-II
name: Eukaryotic initiation factor 4A-II
xref: UnificationXref3660
feature: FragmentFeature672
cellular location: GO:0005829
comment: Reactome DB_ID: 3653350
display name: EIF4A2

SequenceSite438
type: SequenceSite
position status: EQUAL
sequence position: 1

Homologues of EIF4A2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3665
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3653353

SequenceSite439
type: SequenceSite
position status: EQUAL
sequence position: 388

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8MU52
data source: Provenance1
name: Q8MU52
name: Glutathione S-transferase pi 1
xref: UnificationXref3580
feature: FragmentFeature667
cellular location: GO:0005829
comment: Reactome DB_ID: 3654719
display name: GSTP1

ADXL_HUMAN
type: Protein
entity reference: Q8I5R0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8I5R0
name: FDX1L
name: Adrenodoxin-like protein, mitochondrial
xref: UnificationXref3603
feature: FragmentFeature669
cellular location: GO:0005759
comment: Reactome DB_ID: 3657002
display name: FDX2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IHW9
data source: Provenance1
name: Ferredoxin reductase
name: Q8IHW9
name: ADRO_HUMAN
name: NADPH:adrenodoxin oxidoreductase, mitochondrial
xref: UnificationXref3594
feature: FragmentFeature668
cellular location: GO:0005759
comment: Reactome DB_ID: 3656997
display name: FDXR

http://identifiers.org/pubmed/19935667
type: PublicationXref
id: 19935667
author: Hall, RA
author: Ritter, SL
db: Pubmed
title: Fine-tuning of GPCR activity by receptor-interacting proteins
source: Nat Rev Mol Cell Biol 10:819-30
year: 2009

UniProt:Q8ID28
type: ProteinReference
xref: UnificationXref952
organism: BioSource1

http://identifiers.org/pubmed/23604073
type: PublicationXref
id: 23604073
author: Ablasser, A
author: Hopfner, KP
author: Deimling, Tobias
author: Hornung, V
author: Cavlar, Taner
db: Pubmed
title: Species-specific detection of the antiviral small-molecule compound CMA by STING
source: EMBO J. 32:1440-50
year: 2013

UniProt:Q8ID24
type: ProteinReference
xref: UnificationXref4400
organism: BioSource1

UniProt:Q8ID22
type: ProteinReference
xref: UnificationXref5290
organism: BioSource1

SequenceSite440
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite441
type: SequenceSite
position status: EQUAL
sequence position: 388

SequenceSite444
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/11988738
type: PublicationXref
id: 11988738
author: Lukas, J
author: Jackson, PK
author: Reimann, JD
author: Sorensen, CS
author: Hsu, JY
db: Pubmed
title: E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
source: Nat Cell Biol 4:358-66
year: 2002

SequenceSite445
type: SequenceSite
position status: EQUAL
sequence position: 369

SequenceSite442
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite443
type: SequenceSite
position status: EQUAL
sequence position: 369

http://identifiers.org/pubmed/12626323
type: PublicationXref
id: 12626323
author: Jiang, G
author: Zhang, BB
db: Pubmed
title: Glucagon and regulation of glucose metabolism
source: Am J Physiol Endocrinol Metab 284:E671-8
year: 2003

SequenceSite448
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite449
type: SequenceSite
position status: EQUAL
sequence position: 549

SequenceSite446
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite447
type: SequenceSite
position status: EQUAL
sequence position: 424

UniProt:Q9GVB8
type: ProteinReference
xref: UnificationXref144
organism: BioSource1

http://identifiers.org/pubmed/19330724
type: PublicationXref
id: 19330724
author: Chua, JH
author: Armugam, A
author: Jeyaseelan, K
db: Pubmed
title: MicroRNAs: biogenesis, function and applications
source: Curr Opin Mol Ther 11:189-99
year: 2009

http://identifiers.org/pubmed/17223360
type: PublicationXref
id: 17223360
author: Yamane, H
author: Kim, KW
author: Wang, M
author: Busby, J
author: Zondlo, J
db: Pubmed
title: Expression, purification, and characterization of human acetyl-CoA carboxylase 2
source: Protein Expr Purif 53:16-23
year: 2007

UniProt:Q8ID54
type: ProteinReference
xref: UnificationXref3180
organism: BioSource1

UniProt:Q8ID59
type: ProteinReference
xref: UnificationXref4588
organism: BioSource1

http://identifiers.org/pubmed/7565730
type: PublicationXref
id: 7565730
author: van Raaij, TM
author: Riese DJ, 2nd
author: Stern, DF
author: Plowman, GD
author: Andrews, GC
db: Pubmed
title: The cellular response to neuregulins is governed by complex interactions of the erbB receptor family
source: Mol Cell Biol 15:5770-6
year: 1995

UniProt:Q8ID58
type: ProteinReference
xref: UnificationXref3493
organism: BioSource1

http://identifiers.org/pubmed/7968268
type: PublicationXref
id: 7968268
author: Hatch, GM
author: Cao, SG
db: Pubmed
title: Stimulation of phosphatidylglycerolphosphate phosphatase activity by unsaturated fatty acids in rat heart
source: Lipids 29:475-80
year: 1994

http://identifiers.org/pubmed/10521434
type: PublicationXref
id: 10521434
author: Gould, SJ
author: Geisbrecht, BV
db: Pubmed
title: The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase
source: J Biol Chem 274:30527-33
year: 1999

UniProt:Q8ID50
type: ProteinReference
xref: UnificationXref1144
organism: BioSource1

http://identifiers.org/pubmed/1644792
type: PublicationXref
id: 1644792
author: Jhon, DY
author: Rhee, SG
author: Kriz, R
author: Knopf, J
author: Park, D
db: Pubmed
title: Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2
source: J Biol Chem 267:16048-55
year: 1992

Homologues of CPOX(132-454)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3480
cellular location: GO:0005758
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654768

SequenceSite458
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: A8CBI0
data source: Provenance1
name: A8CBI0
name: HEM6_HUMAN
name: Coproporphyrinogen III oxidase, mitochondrial
name: CPOX(132-454)
xref: UnificationXref3477
feature: FragmentFeature653
cellular location: GO:0005758
comment: Reactome DB_ID: 3654765
display name: CPOX

SequenceSite457
type: SequenceSite
position status: EQUAL
sequence position: 155

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IHU1
data source: Provenance1
name: HEM6_HUMAN
name: Coproporphyrinogen III oxidase, mitochondrial
name: CPOX(132-454)
name: Q8IHU1
xref: UnificationXref3479
feature: FragmentFeature654
cellular location: GO:0005758
comment: Reactome DB_ID: 3654767
display name: CPOX

Homologues of FECH
type: Protein
data source: Provenance1
member physical entity: Q8IFR0
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3495
cellular location: GO:0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654820

SequenceSite459
type: SequenceSite
position status: EQUAL
sequence position: 351

Q8IFR0
type: Protein
entity reference: Q8IFR0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Ferrochelatase
name: HEMZ_HUMAN
xref: UnificationXref3492
feature: FragmentFeature655
cellular location: GO:0005759
comment: Reactome DB_ID: 3654817
display name: FECH

SequenceSite454
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8ID58
data source: Provenance1
name: Ferrochelatase
name: Q8ID58
name: HEMZ_HUMAN
xref: UnificationXref3494
feature: FragmentFeature656
cellular location: GO:0005759
comment: Reactome DB_ID: 3654819
display name: FECH

SequenceSite453
type: SequenceSite
position status: EQUAL
sequence position: 205

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I0W6
data source: Provenance1
name: Protoheme IX farnesyltransferase, mitochondrial ecNumber2.5.1.-/ecNumber
name: COX10(?-443)
name: COX10_HUMAN
name: Q8I0W6
xref: UnificationXref3506
feature: FragmentFeature657
cellular location: GO:0005743
comment: Reactome DB_ID: 3657111
display name: COX10

SequenceSite456
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8ILB4
data source: Provenance1
name: COX15_HUMAN
name: Q8ILB4
name: Cytochrome c oxidase assembly protein COX15 homolog
xref: UnificationXref3513
feature: FragmentFeature658
cellular location: GO:0005743
comment: Reactome DB_ID: 3657117
display name: COX15

SequenceSite455
type: SequenceSite
position status: EQUAL
sequence position: 155

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C6KTB4
data source: Provenance1
name: Acetyl-coenzyme A synthetase 2-like, mitochondrial
name: C6KTB4
name: acyl-CoA synthetase short-chain family member 1
xref: UnificationXref3526
feature: FragmentFeature659
cellular location: GO:0005759
comment: Reactome DB_ID: 3655908
display name: ACSS1

SequenceSite450
type: SequenceSite
position status: EQUAL
sequence position: 1

Homologues of GSS(2-474)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3542
cellular location: GO:0005829
comment: Reactome DB_ID: 3654689
comment: Converted from EntitySet in Reactome

SequenceSite452
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite451
type: SequenceSite
position status: EQUAL
sequence position: 364

http://identifiers.org/pubmed/15326200
type: PublicationXref
id: 15326200
author: Sundareshan, S
author: Mazumdar, M
author: Misteli, T
db: Pubmed
title: Human chromokinesin KIF4A functions in chromosome condensation and segregation
source: J Cell Biol 166:613-20
year: 2004

SequenceSite470
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q8ID43
type: ProteinReference
xref: UnificationXref2926
organism: BioSource1

UniProt:Q8ID42
type: ProteinReference
xref: UnificationXref3852
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I3Y4
data source: Provenance1
name: GSS(2-474)
name: Glutathione synthase
xref: UnificationXref3539
feature: FragmentFeature660
cellular location: GO:0005829
comment: Reactome DB_ID: 3654686
display name: Q8I3Y4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q95Z60
data source: Provenance1
name: GSS(2-474)
name: Glutathione synthase
xref: UnificationXref3541
feature: FragmentFeature661
cellular location: GO:0005829
comment: Reactome DB_ID: 3654688
display name: Q95Z60

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8MU52
data source: Provenance1
name: Q8MU52
name: Glutathione S-transferase alpha 1
xref: UnificationXref3572
feature: FragmentFeature663
cellular location: GO:0005829
comment: Reactome DB_ID: 3654711
display name: GSTA1

Homologues of GSTA3(1-222)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3577
cellular location: GO:0005829
comment: Reactome DB_ID: 3654716
comment: Converted from EntitySet in Reactome

SequenceSite469
type: SequenceSite
position status: EQUAL
sequence position: 856

Homologues of GSTA1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3573
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654712

SequenceSite468
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8ILQ7
data source: Provenance1
name: Q8ILQ7
name: Glutathione S-transferase alpha 1
xref: UnificationXref3571
feature: FragmentFeature662
cellular location: GO:0005829
comment: Reactome DB_ID: 3654709
display name: GSTA1

SequenceSite467
type: SequenceSite
position status: EQUAL
sequence position: 856

Homologues of GSTP1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3581
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654720

SequenceSite466
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8ILQ7
data source: Provenance1
name: Q8ILQ7
name: Glutathione S-transferase pi 1
xref: UnificationXref3579
feature: FragmentFeature666
cellular location: GO:0005829
comment: Reactome DB_ID: 3654718
display name: GSTP1

SequenceSite465
type: SequenceSite
position status: EQUAL
sequence position: 837

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8ILQ7
data source: Provenance1
name: Q8ILQ7
name: Glutathione S-transferase alpha 3
name: GSTA3(1-222)
xref: UnificationXref3575
feature: FragmentFeature664
cellular location: GO:0005829
comment: Reactome DB_ID: 3654714
display name: GSTA3

SequenceSite464
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8MU52
data source: Provenance1
name: Q8MU52
name: Glutathione S-transferase alpha 3
name: GSTA3(1-222)
xref: UnificationXref3576
feature: FragmentFeature665
cellular location: GO:0005829
comment: Reactome DB_ID: 3654715
display name: GSTA3

SequenceSite463
type: SequenceSite
position status: EQUAL
sequence position: 837

SequenceSite462
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite461
type: SequenceSite
position status: EQUAL
sequence position: 350

SequenceSite460
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite480
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite481
type: SequenceSite
position status: EQUAL
sequence position: 1132

http://identifiers.org/pubmed/11242114
type: PublicationXref
id: 11242114
author: Brahmbhatt, SB
author: Hulme, DJ
author: Nicholson, GA
author: Dawkins, JL
author: Auer-Grumbach, M
db: Pubmed
title: Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I
source: Nat Genet 27:309-12
year: 2001

SequenceSite479
type: SequenceSite
position status: EQUAL
sequence position: 1177

Homologues of SRM
type: Protein
data source: Provenance1
member physical entity: Spermidine synthase
xref: UnificationXref3375
cellular location: GO:0005829
comment: Reactome DB_ID: 3655270
comment: Converted from EntitySet in Reactome

Spermidine synthase
type: Protein
entity reference: Q8II73
data source: Provenance1
name: Q8II73
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3372
feature: FragmentFeature639
cellular location: GO:0005829
comment: Reactome DB_ID: 3655267
display name: SRM

Spermidine synthase
type: Protein
entity reference: Q9NFS5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q9NFS5
xref: UnificationXref3374
feature: FragmentFeature640
cellular location: GO:0005829
comment: Reactome DB_ID: 3655269
display name: SRM

SequenceSite472
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q27733
data source: Provenance1
name: 5-aminolevulinate synthase, erythroid (pyridoxal phosphate cofactor)
name: Q27733
name: 5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor
name: HEM0_HUMAN
name: PXLP-ALAS2
xref: UnificationXref3394
feature: FragmentFeature643
feature: ModificationFeature35
cellular location: GO:0005759
comment: Reactome DB_ID: 3654806
display name: ALAS2

SequenceSite471
type: SequenceSite
position status: EQUAL
sequence position: 840

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I4X1
data source: Provenance1
name: 5-aminolevulinate synthase, erythroid (pyridoxal phosphate cofactor)
name: 5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor
name: Q8I4X1
name: HEM0_HUMAN
name: PXLP-ALAS2
xref: UnificationXref3395
feature: ModificationFeature36
feature: FragmentFeature644
cellular location: GO:0005759
comment: Reactome DB_ID: 3654807
display name: ALAS2

SequenceSite474
type: SequenceSite
position status: EQUAL
sequence position: 1

Homologues of ALAD
type: Protein
data source: Provenance1
member physical entity: Q8MYK5
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q8IL68
xref: UnificationXref3415
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654792

SequenceSite473
type: SequenceSite
position status: EQUAL
sequence position: 840

SequenceSite476
type: SequenceSite
position status: EQUAL
sequence position: 1

Homologues of PXLP-ALAS1
type: Protein
data source: Provenance1
member physical entity: 5-aminolevulinate synthase, non-specific (pyridoxal phosphate cofactor)
xref: UnificationXref3392
cellular location: GO:0005759
comment: Reactome DB_ID: 3654804
comment: Converted from EntitySet in Reactome

SequenceSite475
type: SequenceSite
position status: EQUAL
sequence position: 830

5-aminolevulinate synthase, non-specific (pyridoxal phosphate cofactor)
type: Protein
entity reference: Q27733
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q27733
name: PXLP-ALAS1
name: 5-aminolevulinate synthase, non-specific, mitochondrial
name: HEM1_HUMAN
xref: UnificationXref3389
feature: FragmentFeature641
feature: ModificationFeature35
cellular location: GO:0005759
comment: Reactome DB_ID: 3654800
display name: ALAS1

SequenceSite478
type: SequenceSite
position status: EQUAL
sequence position: 1

5-aminolevulinate synthase, non-specific (pyridoxal phosphate cofactor)
type: Protein
entity reference: Q8I4X1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8I4X1
name: PXLP-ALAS1
name: 5-aminolevulinate synthase, non-specific, mitochondrial
name: HEM1_HUMAN
xref: UnificationXref3391
feature: ModificationFeature36
feature: FragmentFeature642
cellular location: GO:0005759
comment: Reactome DB_ID: 3654803
display name: ALAS1

Synthesis and interconversion of nucleotide di- and triphosphates
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction178
pathway component: BiochemicalReaction180
pathway component: BiochemicalReaction172
pathway component: BiochemicalReaction175
pathway component: BiochemicalReaction185
pathway component: BiochemicalReaction177
pathway component: BiochemicalReaction176
pathway component: BiochemicalReaction174
pathway component: BiochemicalReaction182
pathway component: BiochemicalReaction171
pathway component: BiochemicalReaction181
pathway component: BiochemicalReaction183
pathway component: BiochemicalReaction184
pathway component: BiochemicalReaction173
pathway component: BiochemicalReaction179
evidence: Evidence346
xref: RelationshipXref348
xref: UnificationXref2976
xref: UnificationXref2975
pathway order: PathwayStep335
pathway order: PathwayStep329
pathway order: PathwayStep340
pathway order: PathwayStep334
pathway order: PathwayStep326
pathway order: PathwayStep337
pathway order: PathwayStep330
pathway order: PathwayStep328
pathway order: PathwayStep339
pathway order: PathwayStep327
pathway order: PathwayStep338
pathway order: PathwayStep331
pathway order: PathwayStep332
pathway order: PathwayStep333
pathway order: PathwayStep336
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite477
type: SequenceSite
position status: EQUAL
sequence position: 830

Homologues of PXLP-ALAS2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3396
cellular location: GO:0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654808

SequenceSite491
type: SequenceSite
position status: EQUAL
sequence position: 139

SequenceSite492
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite490
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/11242102
type: PublicationXref
id: 11242102
author: Khanna, KK
db: Pubmed
title: DNA double-strand breaks: signaling, repair and the cancer connection.
source: Nat Genet 27:247-54
year: 2001

Q8IL68
type: Protein
entity reference: Q8IL68
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: HEM2_HUMAN
name: Delta-aminolevulinic acid dehydratase
xref: UnificationXref3412
feature: FragmentFeature647
cellular location: GO:0005829
comment: Reactome DB_ID: 3654789
display name: ALAD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8MTV7
data source: Provenance1
name: HEM2_HUMAN
name: Delta-aminolevulinic acid dehydratase
name: Q8MTV7
xref: UnificationXref3414
feature: FragmentFeature648
cellular location: GO:0005829
comment: Reactome DB_ID: 3654791
display name: ALAD

Q8MYK5
type: Protein
entity reference: UniProt:Q8MYK5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: HEM2_HUMAN
name: Delta-aminolevulinic acid dehydratase
xref: UnificationXref3408
feature: FragmentFeature645
cellular location: GO:0005829
comment: Reactome DB_ID: 3654785
display name: ALAD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U0R8
data source: Provenance1
name: HEM2_HUMAN
name: Delta-aminolevulinic acid dehydratase
name: Q9U0R8
xref: UnificationXref3410
feature: FragmentFeature646
cellular location: GO:0005829
comment: Reactome DB_ID: 3654787
display name: ALAD

UniProt:D0QXK6
type: ProteinReference
xref: UnificationXref2771
organism: BioSource1

SequenceSite485
type: SequenceSite
position status: EQUAL
sequence position: 80

UniProt:D0QXK5
type: ProteinReference
xref: UnificationXref2753
organism: BioSource1

SequenceSite484
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:D0QXK8
type: ProteinReference
xref: UnificationXref2777
organism: BioSource1

SequenceSite483
type: SequenceSite
position status: EQUAL
sequence position: 95

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C6KSS1
data source: Provenance1
name: DCUP_HUMAN
name: Uroporphyrinogen III decarboxylase
name: C6KSS1
xref: UnificationXref3448
feature: FragmentFeature651
cellular location: GO:0005829
comment: Reactome DB_ID: 3654775
display name: UROD

UniProt:D0QXK7
type: ProteinReference
xref: UnificationXref2755
organism: BioSource1

SequenceSite482
type: SequenceSite
position status: EQUAL
sequence position: 1

A8CBI1
type: Protein
entity reference: A8CBI1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DCUP_HUMAN
name: Uroporphyrinogen III decarboxylase
xref: UnificationXref3450
feature: FragmentFeature652
cellular location: GO:0005829
comment: Reactome DB_ID: 3654777
display name: UROD

UniProt:D0QXK2
type: ProteinReference
xref: UnificationXref2751
organism: BioSource1

SequenceSite489
type: SequenceSite
position status: EQUAL
sequence position: 102

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: A8CBH8
data source: Provenance1
name: HEM3_HUMAN
name: A8CBH8
name: Porphobilinogen deaminase
xref: UnificationXref3433
feature: FragmentFeature650
cellular location: GO:0005829
comment: Reactome DB_ID: 3654757
display name: HMBS

SequenceSite488
type: SequenceSite
position status: EQUAL
sequence position: 2

Homologues of UROD
type: Protein
data source: Provenance1
member physical entity: A8CBI1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3451
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654778

UniProt:D0QXK4
type: ProteinReference
xref: UnificationXref2735
organism: BioSource1

SequenceSite487
type: SequenceSite
position status: EQUAL
sequence position: 91

Homologues of HMBS
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3434
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654758

SequenceSite486
type: SequenceSite
position status: EQUAL
sequence position: 2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8I5V3
data source: Provenance1
name: HEM3_HUMAN
name: Porphobilinogen deaminase
name: Q8I5V3
xref: UnificationXref3431
feature: FragmentFeature649
cellular location: GO:0005829
comment: Reactome DB_ID: 3654755
display name: HMBS

http://identifiers.org/pubmed/16413920
type: PublicationXref
id: 16413920
author: Nimmerjahn, F
author: Ravetch, JV
db: Pubmed
title: Fcgamma receptors: old friends and new family members
source: Immunity 24:19-28
year: 2006

http://identifiers.org/pubmed/11779870
type: PublicationXref
id: 11779870
author: Tsurumi, T
author: Fujita, M
author: Kiyono, T
author: Nakamura, H
author: Ishimi, Y
db: Pubmed
title: Nuclear organization of DNA replication initiation proteins in mammalian cells.
source: J Biol Chem 277:10354-61
year: 2002

http://identifiers.org/pubmed/12205100
type: PublicationXref
id: 12205100
author: Van Komen, S
author: Sigurdsson, S
author: Petukhova, G
author: Sung, P
db: Pubmed
title: Homologous DNA pairing by human recombination factors Rad51 and Rad54
source: J Biol Chem 277:42790-4
year: 2002

SequenceSite495
type: SequenceSite
position status: EQUAL
sequence position: 355

SequenceSite496
type: SequenceSite
position status: EQUAL
sequence position: 83

SequenceSite493
type: SequenceSite
position status: EQUAL
sequence position: 103

SequenceSite494
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/3413114
type: PublicationXref
id: 3413114
author: Cram, LS
author: Wu, JR
author: Ratliff, RL
author: Buckingham, JM
author: Moyzis, RK
author: Jones, MD
author: Meyne, J
author: Deaven, LL
author: Dani, M
db: Pubmed
title: A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
source: Proc Natl Acad Sci U S A 85:6622-6
year: 1988

http://identifiers.org/pubmed/9564029
type: PublicationXref
id: 9564029
author: Kushner, JP
author: Phillips, JD
author: Hill, CP
author: Whitby, FG
db: Pubmed
title: Crystal structure of human uroporphyrinogen decarboxylase
source: EMBO J 17:2463-71
year: 1998

SequenceSite499
type: SequenceSite
position status: EQUAL
sequence position: 355

SequenceSite497
type: SequenceSite
position status: EQUAL
sequence position: 87

SequenceSite498
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/16793762
type: PublicationXref
id: 16793762
author: Pewzner-Jung, Y
author: Ben-Dor, S
author: Futerman, AH
db: Pubmed
title: When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis
source: J Biol Chem 281:25001-5
year: 2006

http://identifiers.org/pubmed/4218100
type: PublicationXref
id: 4218100
author: Matalon, R
author: Brandt, IK
author: Dorfman, A
author: Justice, P
author: Arbogast, B
db: Pubmed
title: Morquio's syndrome: deficiency of a chondroitin sulfate N-acetylhexosamine sulfate sulfatase
source: Biochem Biophys Res Commun 61:759-65
year: 1974

http://identifiers.org/pubmed/7990965
type: PublicationXref
id: 7990965
author: Rasmussen, HH
author: Philippe, M
author: Drugeon, G
author: Celis, JE
author: Kress, M
author: Frolova, L
author: Cheperegin, S
author: Arman, I
author: Haenni, AL
author: Le, Goff X
db: Pubmed
title: A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor
source: Nature 372:701-3
year: 1994

Ketone body metabolism
type: Pathway
data source: Provenance1
pathway component: Utilization of Ketone Bodies
pathway component: REACT 86263.9
evidence: Evidence210
xref: UnificationXref1798
xref: RelationshipXref179
xref: UnificationXref1797
pathway order: PathwayStep202
pathway order: PathwayStep204
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

PublicationXref336
type: PublicationXref
id: 0121227022
author: Noltmann, EA
db: ISBN
title: Aldose-ketose isomerases
source: The Enzymes, 3rd ed (Book): 271-354
year: 1972

PublicationXref339
type: PublicationXref
id: 0121227022
author: Lardy, HA
author: Bloxham, DP
db: ISBN
title: Phosphofructokinase
source: The Enzymes, 3rd ed (Book): 239-278
year: 1973

http://identifiers.org/pubmed/10529898
type: PublicationXref
id: 10529898
author: Wahli, W
author: Desvergne, B
db: Pubmed
title: Peroxisome proliferator-activated receptors: nuclear control of metabolism
source: Endocr Rev 20:649-88
year: 1999

(R)-2-hydroxyglutaric acid
type: SmallMoleculeReference
name: (R)-2-Hydroxyglutarate
name: ChEBI:32796 (R)-2-hydroxyglutaric acid
xref: UnificationXref354

ChEBI:32797 (S)-2-Hydroxyglutarate
type: SmallMoleculeReference
name: (S)-2-Hydroxyglutarate
xref: UnificationXref2501

http://identifiers.org/pubmed/3208766
type: PublicationXref
id: 3208766
author: Day, IN
author: Fothergill, JE
author: McAleese, SM
author: Hinks, LJ
author: Dunbar, B
db: Pubmed
title: Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE)
source: Eur J Biochem 178:413-7
year: 1988

http://identifiers.org/pubmed/20930137
type: PublicationXref
id: 20930137
author: Kull, FJ
author: Endow, SA
author: Liu, H
db: Pubmed
title: Kinesins at a glance
source: J Cell Sci 123:3420-4
year: 2010

http://identifiers.org/pubmed/19540337
type: PublicationXref
id: 19540337
author: Masson, K
author: Rönnstrand, L
db: Pubmed
title: Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
source: Cell Signal 21:1717-26
year: 2009

http://identifiers.org/pubmed/9083101
type: PublicationXref
id: 9083101
author: Hosaka, K
author: Nikawa, J
author: Nakashima, A
db: Pubmed
title: Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant
source: J Biol Chem 272:9567-72
year: 1997

Removal of licensing factors from origins
type: Pathway
data source: Provenance1
pathway component: REACT 93416.9
pathway component: BiochemicalReaction309
evidence: Evidence609
xref: UnificationXref5025
xref: UnificationXref5024
pathway order: PathwayStep577
pathway order: PathwayStep576
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

PublicationXref374
type: PublicationXref
author: Gitzelmann, R
author: Steinmann, B
author: Van den Berghe, G
title: Disorders of fructose metabolism
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Scriver CR, et al., editors) 1:1489-1520
year: 2001

PublicationXref375
type: PublicationXref
author: Hers, HG
title: Triokinases
source: The Enzymes, 2nd ed (Boyer PD, Lardy H, Myrback K, editors) 6:75-83
year: 1962

PublicationXref376
type: PublicationXref
author: Tyfield, LA
author: Walter, JH
author: Holton, JB
title: Galactosemia
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Scriver CR, et al., editors) 1:1553-1587
year: 2001

UniProt:P18240
type: ProteinReference
xref: UnificationXref1254
organism: BioSource1

http://identifiers.org/pubmed/6338048
type: PublicationXref
id: 6338048
author: McLaren, KM
db: Pubmed
title: Immunohistochemical localisation of thrombospondin in human megakaryocytes and platelets
source: J Clin Pathol 36:197-9
year: 1983

Coenzyme A biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction198
pathway component: BiochemicalReaction197
pathway component: BiochemicalReaction195
pathway component: BiochemicalReaction196
evidence: Evidence364
xref: RelationshipXref378
xref: UnificationXref3109
xref: UnificationXref3108
pathway order: PathwayStep358
pathway order: PathwayStep356
pathway order: PathwayStep357
pathway order: PathwayStep355
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Vitamin B5 (pantothenate) metabolism
type: Pathway
data source: Provenance1
pathway component: Coenzyme A biosynthesis
evidence: Evidence365
xref: RelationshipXref379
xref: UnificationXref3111
xref: UnificationXref3110
pathway order: PathwayStep359
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/12151002
type: PublicationXref
id: 12151002
author: Paiement, J
author: Desjardins, M
author: Bergeron, JJ
author: Cameron, PH
author: Duclos, S
author: Chevet, E
author: Gagnon, E
author: Steele-Mortimer, O
author: Rondeau, C
db: Pubmed
title: Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages
source: Cell 110:119-31
year: 2002

http://identifiers.org/pubmed/17517897
type: PublicationXref
id: 17517897
author: Wilson, GM
author: Toth, EA
author: Willis, CD
author: Ballin, JD
author: Brewer, BY
author: Fialcowitz-White, EJ
db: Pubmed
title: Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences
source: J Biol Chem 282:20948-59
year: 2007

UnificationXref1808
type: UnificationXref
id: REACT_18250
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18250.2

RelationshipXref80
type: RelationshipXref
id: GO:0004674
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1807
type: UnificationXref
id: 188451
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=188451

RelationshipXref81
type: RelationshipXref
id: 3656243
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656243

RelationshipXref82
type: RelationshipXref
id: GO:0000184
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1809
type: UnificationXref
id: O97245
db: UniProt

RelationshipXref83
type: RelationshipXref
id: GO:0016071
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref84
type: RelationshipXref
id: GO:0016070
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref85
type: RelationshipXref
id: GO:0004347
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref86
type: RelationshipXref
id: 3652860
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652860

RelationshipXref87
type: RelationshipXref
id: GO:0004332
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1800
type: UnificationXref
id: 113596
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113596

RelationshipXref88
type: RelationshipXref
id: 3652796
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652796

RelationshipXref89
type: RelationshipXref
id: GO:0004807
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1802
type: UnificationXref
id: 188458
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=188458

UnificationXref1801
type: UnificationXref
id: REACT_5229
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5229.1

UnificationXref1804
type: UnificationXref
id: CHEBI:17877
db: ChEBI

UnificationXref1803
type: UnificationXref
id: REACT_18103
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18103.2

UnificationXref1806
type: UnificationXref
id: REACT_3082
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3082.1

UnificationXref1805
type: UnificationXref
id: 31649
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31649

UnificationXref194
type: UnificationXref
id: 3654138
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654138

UnificationXref195
type: UnificationXref
id: O96197
db: UniProt

UnificationXref192
type: UnificationXref
id: C0H4V6
db: UniProt

UnificationXref193
type: UnificationXref
id: 3654137
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654137

UnificationXref198
type: UnificationXref
id: 3654139
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654139

UnificationXref199
type: UnificationXref
id: 3654140
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654140

UnificationXref196
type: UnificationXref
id: MOD:00046
db: MOD

UnificationXref197
type: UnificationXref
id: 3654131
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654131

Regulatory RNA pathways
type: Pathway
data source: Provenance1
pathway component: REACT 92137.9
evidence: Evidence725
xref: UnificationXref5564
xref: UnificationXref5563
pathway order: PathwayStep704
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref92
type: RelationshipXref
id: 3652869
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652869

RelationshipXref93
type: RelationshipXref
id: GO:0004619
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/11347887
type: PublicationXref
id: 11347887
author: Hou, YM
author: King, MP
author: Davidson, E
author: Vitseva, O
author: Caffarella, J
db: Pubmed
title: Isolation of two cDNAs encoding functional human cytoplasmic cysteinyl-tRNA synthetase
source: Biol Chem 382:399-406
year: 2001

RelationshipXref90
type: RelationshipXref
id: 3652853
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652853

RelationshipXref91
type: RelationshipXref
id: GO:0004618
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref96
type: RelationshipXref
id: 3652879
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652879

RelationshipXref97
type: RelationshipXref
id: GO:0006096
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref94
type: RelationshipXref
id: 3653041
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653041

RelationshipXref95
type: RelationshipXref
id: GO:0004634
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref98
type: RelationshipXref
id: GO:0015367
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref99
type: RelationshipXref
id: 3654951
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654951

UnificationXref191
type: UnificationXref
id: 3654135
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654135

UniProt:Q8IDA0
type: ProteinReference
xref: UnificationXref146
organism: BioSource1

UnificationXref190
type: UnificationXref
id: O61132
db: UniProt

UnificationXref185
type: UnificationXref
id: REACT_114446
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114446.8

UnificationXref186
type: UnificationXref
id: 3657227
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657227

UnificationXref187
type: UnificationXref
id: REACT_112227
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112227.8

UnificationXref188
type: UnificationXref
id: 3657238
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657238

UnificationXref181
type: UnificationXref
id: REACT_114172
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114172.8

UnificationXref182
type: UnificationXref
id: 3657328
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657328

UnificationXref183
type: UnificationXref
id: REACT_114897
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114897.8

UnificationXref184
type: UnificationXref
id: 3657220
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657220

UnificationXref189
type: UnificationXref
id: REACT_115037
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115037.8

http://identifiers.org/pubmed/10413847
type: PublicationXref
id: 10413847
author: Bläker, M
author: de Weerth, A
author: von Schrenck, T
db: Pubmed
title: [Receptors for cholecystokinin and gastrin]
source: Z Gastroenterol 37:389-401
year: 1999

UniProt:Q8IDB0
type: ProteinReference
xref: UnificationXref1037
organism: BioSource1

UniProt:Q8IDB3
type: ProteinReference
xref: UnificationXref3052
organism: BioSource1

UnificationXref180
type: UnificationXref
id: 3657327
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657327

UniProt:Q8IDB7
type: ProteinReference
xref: UnificationXref961
organism: BioSource1

UnificationXref176
type: UnificationXref
id: 3654361
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654361

UnificationXref177
type: UnificationXref
id: REACT_154350
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154350.3

UnificationXref174
type: UnificationXref
id: 3654358
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654358

UnificationXref175
type: UnificationXref
id: 3654360
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654360

UnificationXref172
type: UnificationXref
id: 3654356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654356

UnificationXref173
type: UnificationXref
id: 3654357
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654357

UnificationXref170
type: UnificationXref
id: 3654354
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654354

UnificationXref171
type: UnificationXref
id: 3654355
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654355

UnificationXref178
type: UnificationXref
id: 3657326
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657326

UnificationXref179
type: UnificationXref
id: REACT_92884
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92884.9

http://identifiers.org/pubmed/19196647
type: PublicationXref
id: 19196647
author: McCrea, HJ
author: De Camilli, P
db: Pubmed
title: Mutations in phosphoinositide metabolizing enzymes and human disease
source: Physiology (Bethesda) 24:8-16
year: 2009

UniProt:Q8IDC6
type: ProteinReference
xref: UnificationXref3222
organism: BioSource1

UnificationXref168
type: UnificationXref
id: 3654352
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654352

UnificationXref167
type: UnificationXref
id: 3654351
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654351

UnificationXref169
type: UnificationXref
id: 3654353
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654353

UnificationXref160
type: UnificationXref
id: 3654344
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654344

UnificationXref162
type: UnificationXref
id: 3654346
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654346

UnificationXref161
type: UnificationXref
id: 3654345
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654345

UnificationXref164
type: UnificationXref
id: 3654348
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654348

UnificationXref1851
type: UnificationXref
id: 3657422
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657422

Eukaryotic Translation Initiation
type: Pathway
data source: Provenance1
pathway component: REACT 78375.9
pathway component: REACT 30653.10
evidence: Evidence469
xref: UnificationXref3826
xref: UnificationXref3827
xref: RelationshipXref470
pathway order: PathwayStep427
pathway order: PathwayStep455
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref163
type: UnificationXref
id: 3654347
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654347

UnificationXref1850
type: UnificationXref
id: REACT_115223
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115223.8

Interleukin-2 signaling
type: Pathway
data source: Provenance1
pathway component: REACT 157443.3
evidence: Evidence795
xref: UnificationXref5960
xref: UnificationXref5961
pathway order: PathwayStep16
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref166
type: UnificationXref
id: 3654350
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654350

UnificationXref1853
type: UnificationXref
id: 3657423
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657423

http://identifiers.org/pubmed/13211603
type: PublicationXref
id: 13211603
author: Joklik, WK
author: Berg, P
db: Pubmed
title: Enzymatic phosphorylation of nucleoside diphosphates
source: J Biol Chem 210:657-672
year: 1954

UnificationXref165
type: UnificationXref
id: 3654349
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654349

UnificationXref1852
type: UnificationXref
id: REACT_114218
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114218.8

UnificationXref1843
type: UnificationXref
id: 3655513
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655513

UnificationXref1844
type: UnificationXref
id: REACT_83622
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83622.9

UnificationXref1845
type: UnificationXref
id: 389545
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389545

UnificationXref1846
type: UnificationXref
id: REACT_17299
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17299.2

UnificationXref1847
type: UnificationXref
id: 3655506
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655506

UnificationXref1848
type: UnificationXref
id: 3655507
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655507

UniProt:Q8IDD3
type: ProteinReference
xref: UnificationXref5433
organism: BioSource1

UnificationXref1849
type: UnificationXref
id: 3655509
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655509

UnificationXref159
type: UnificationXref
id: 3654343
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654343

UnificationXref158
type: UnificationXref
id: 3654342
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654342

UnificationXref157
type: UnificationXref
id: 3654341
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654341

UnificationXref156
type: UnificationXref
id: 3654340
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654340

UnificationXref151
type: UnificationXref
id: 3654335
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654335

UnificationXref150
type: UnificationXref
id: 3654334
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654334

UnificationXref155
type: UnificationXref
id: 3654339
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654339

UnificationXref1842
type: UnificationXref
id: 3655511
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655511

UnificationXref154
type: UnificationXref
id: 3654338
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654338

UnificationXref1841
type: UnificationXref
id: 3655510
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655510

http://identifiers.org/pubmed/9630229
type: PublicationXref
id: 9630229
author: Vainberg, IE
author: Klein, HL
author: Vandekerckhove, J
author: Rommelaere, H
author: Cowan, NJ
author: Lewis, SA
author: Ampe, C
db: Pubmed
title: Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin
source: Cell 93:863-73
year: 1998

UnificationXref153
type: UnificationXref
id: 3654337
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654337

UnificationXref1840
type: UnificationXref
id: REACT_17799
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17799.1

UnificationXref152
type: UnificationXref
id: 3654336
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654336

UnificationXref1834
type: UnificationXref
id: REACT_5821
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5821.1

UnificationXref1835
type: UnificationXref
id: 193465
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193465

UnificationXref1832
type: UnificationXref
id: REACT_17375
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17375.1

UnificationXref1833
type: UnificationXref
id: 113602
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113602

UnificationXref1838
type: UnificationXref
id: REACT_17938
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17938.2

UnificationXref1839
type: UnificationXref
id: 389536
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389536

UnificationXref1836
type: UnificationXref
id: REACT_10257
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10257.1

UnificationXref1837
type: UnificationXref
id: 389537
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389537

UnificationXref149
type: UnificationXref
id: 3654333
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654333

http://identifiers.org/pubmed/21029861
type: PublicationXref
id: 21029861
author: Hogg, JR
author: Goff, SP
db: Pubmed
title: Upf1 senses 3'UTR length to potentiate mRNA decay
source: Cell 143:379-89
year: 2010

http://identifiers.org/pubmed/7493035
type: PublicationXref
id: 7493035
author: Morris, CP
author: Hopwood, JJ
author: Blanch, L
author: Guo, XH
author: Sutherland, GR
author: Freeman, C
author: Baker, E
author: Orsborn, A
author: Scott, HS
db: Pubmed
title: Cloning of the sulphamidase gene and identification of mutations in Sanfilippo A syndrome
source: Nat Genet 11:465-7
year: 1995

http://identifiers.org/pubmed/11278511
type: PublicationXref
id: 11278511
author: Ding, WC
author: Berger, SH
author: Lebioda, L
author: Koli, S
author: Minor, W
author: Dunlap, RB
author: Phan, J
author: Steadman, DJ
db: Pubmed
title: Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
source: J Biol Chem 276:14170-7
year: 2001

UnificationXref146
type: UnificationXref
id: Q8IDA0
db: UniProt

UnificationXref145
type: UnificationXref
id: 3654329
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654329

UnificationXref148
type: UnificationXref
id: 3654332
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654332

UnificationXref147
type: UnificationXref
id: 3654331
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654331

UnificationXref142
type: UnificationXref
id: 140344
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=140344

UnificationXref141
type: UnificationXref
id: CHEBI:18420
db: ChEBI

UnificationXref144
type: UnificationXref
id: Q9GVB8
db: UniProt

UnificationXref1831
type: UnificationXref
id: 389556
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389556

UnificationXref143
type: UnificationXref
id: REACT_2939
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2939.2

UnificationXref1830
type: UnificationXref
id: REACT_17953
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17953.2

http://identifiers.org/pubmed/59727
type: PublicationXref
id: 59727
author: Nachman, RL
author: Harpel, PC
db: Pubmed
title: Platelet alpha2-macroglobulin and alpha1-antitrypsin
source: J Biol Chem 251:4512-21
year: 1976

UnificationXref140
type: UnificationXref
id: REACT_5692
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5692.2

UniProt:Q8IDF7
type: ProteinReference
xref: UnificationXref60
organism: BioSource1

UnificationXref1825
type: UnificationXref
id: 3657216
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657216

UnificationXref1826
type: UnificationXref
id: REACT_90141
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90141.9

UnificationXref1827
type: UnificationXref
id: GO:0005782
db: GENE ONTOLOGY

http://identifiers.org/pubmed/10625641
type: PublicationXref
id: 10625641
author: Lopez-Jimenez, M
author: Ramesh, B
author: Srai, SK
author: Dedes, M
author: Williams, M
author: Leggett, A
author: Sharp, P
author: Tandy, S
db: Pubmed
title: Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells
source: J Biol Chem 275:1023-9
year: 2000

UniProt:Q8IDF6
type: ProteinReference
xref: UnificationXref2555
organism: BioSource1

UnificationXref1828
type: UnificationXref
id: CHEBI:151
db: ChEBI

UnificationXref1821
type: UnificationXref
id: 3657531
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657531

UnificationXref1822
type: UnificationXref
id: REACT_138371
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138371.5

UniProt:Q8IDF9
type: ProteinReference
xref: UnificationXref1469
organism: BioSource1

UnificationXref1823
type: UnificationXref
id: 3657532
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657532

UnificationXref1824
type: UnificationXref
id: REACT_138206
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138206.5

UniProt:Q8IDF0
type: ProteinReference
xref: UnificationXref4924
organism: BioSource1

UnificationXref1829
type: UnificationXref
id: 389548
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389548

UnificationXref139
type: UnificationXref
id: 111294
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111294

UnificationXref138
type: UnificationXref
id: CHEBI:29888
db: ChEBI

UnificationXref137
type: UnificationXref
id: REACT_3751
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3751.1

UnificationXref136
type: UnificationXref
id: 30389
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30389

UnificationXref135
type: UnificationXref
id: CHEBI:17489
db: ChEBI

UnificationXref134
type: UnificationXref
id: REACT_2812
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2812.1

UnificationXref133
type: UnificationXref
id: 113592
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592

UnificationXref1820
type: UnificationXref
id: REACT_135513
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135513.5

UnificationXref132
type: UnificationXref
id: CHEBI:15422
db: ChEBI

http://identifiers.org/pubmed/9477959
type: PublicationXref
id: 9477959
author: Gould, GW
author: De la Rue, SA
author: Porter, LM
author: Seatter, MJ
db: Pubmed
title: QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 position of D-glucose and is involved in substrate selection at the exofacial binding site.
source: Biochemistry 37:1322-6
year: 1998

UnificationXref131
type: UnificationXref
id: REACT_134138
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134138.5

UnificationXref130
type: UnificationXref
id: 3653805
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653805

http://identifiers.org/pubmed/8617223
type: PublicationXref
id: 8617223
author: Cole, TB
author: Findley, SD
author: Palmiter, RD
db: Pubmed
title: ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration
source: EMBO J 15:1784-91
year: 1996

UnificationXref1816
type: UnificationXref
id: REACT_156512
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156512.3

UnificationXref1817
type: UnificationXref
id: P61076
db: UniProt

UnificationXref1814
type: UnificationXref
id: 3656911
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656911

UnificationXref1815
type: UnificationXref
id: 3656912
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656912

UnificationXref1812
type: UnificationXref
id: REACT_102204
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102204.9

UnificationXref1813
type: UnificationXref
id: Q8I469
db: UniProt

UnificationXref1810
type: UnificationXref
id: 3654742
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654742

UnificationXref1811
type: UnificationXref
id: 3654744
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654744

http://identifiers.org/pubmed/16483568
type: PublicationXref
id: 16483568
author: Da Silva, CA
author: Frossard, N
author: Reber, L
db: Pubmed
title: Stem cell factor and its receptor c-Kit as targets for inflammatory diseases
source: Eur J Pharmacol 533:327-40
year: 2006

http://identifiers.org/pubmed/21781017
type: PublicationXref
id: 21781017
author: Pulimeno, P
author: Stutz, J
author: Spadaro, D
author: Schneider, Y
author: Citi, S
db: Pubmed
title: Regulation of small GTPases at epithelial cell-cell junctions
source: Mol Membr Biol
year: 2011

UniProt:Q8IDG2
type: ProteinReference
xref: UnificationXref902
organism: BioSource1

UniProt:Q8IDG3
type: ProteinReference
xref: UnificationXref894
organism: BioSource1

UnificationXref1818
type: UnificationXref
id: 3656906
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656906

UnificationXref1819
type: UnificationXref
id: 3656907
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656907

RelationshipXref32
type: RelationshipXref
id: GO:0015232
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1855
type: UnificationXref
id: CHEBI:16057
db: ChEBI

http://identifiers.org/pubmed/16391004
type: PublicationXref
id: 16391004
author: Osborne, HB
author: Barreau, C
author: Paillard, L
db: Pubmed
title: AU-rich elements and associated factors: are there unifying principles?
source: Nucleic Acids Res 33:7138-50
year: 2005

RelationshipXref33
type: RelationshipXref
id: 3656417
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656417

UnificationXref1854
type: UnificationXref
id: REACT_143506
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143506.5

RelationshipXref34
type: RelationshipXref
id: GO:0043225
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1857
type: UnificationXref
id: REACT_9855
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9855.2

RelationshipXref35
type: RelationshipXref
id: 3656548
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656548

UnificationXref1856
type: UnificationXref
id: 191324
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191324

RelationshipXref36
type: RelationshipXref
id: GO:0055085
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1859
type: UnificationXref
id: 191362
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191362

RelationshipXref37
type: RelationshipXref
id: GO:0015321
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1858
type: UnificationXref
id: CHEBI:16584
db: ChEBI

RelationshipXref38
type: RelationshipXref
id: 3655686
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655686

RelationshipXref39
type: RelationshipXref
id: GO:0006811
db: GENE ONTOLOGY
relationship type: MI:0359

Homologues of SRP54
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3843
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656761

UnificationXref209
type: UnificationXref
id: 3657239
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657239

http://identifiers.org/pubmed/10659855
type: PublicationXref
id: 10659855
author: Dever, TE
author: Lee, JH
author: Pestova, TV
author: Choi, SK
author: Lomakin, IB
author: Hellen, CU
db: Pubmed
title: The joining of ribosomal subunits in eukaryotes requires eIF5B.
source: Nature 403:332-5
year: 2000

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:F2X1X7
data source: Provenance1
name: F2X1X7
name: SRP19(2-144)
xref: UnificationXref3837
feature: FragmentFeature707
cellular location: GO:0005829
comment: Reactome DB_ID: 3656753
display name: SRP19

UnificationXref208
type: UnificationXref
id: REACT_156010
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156010.3

http://identifiers.org/pubmed/13115431
type: PublicationXref
id: 13115431
author: Lieberman, I
author: Kornberg, A
db: Pubmed
title: Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase
source: Biochim Biophys Acta 12:223-234
year: 1953

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I5P4
data source: Provenance1
name: SRP19(2-144)
name: Q8I5P4
xref: UnificationXref3835
feature: FragmentFeature706
cellular location: GO:0005829
comment: Reactome DB_ID: 3656751
display name: SRP19

Homologues of SRP19(2-144)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3838
cellular location: GO:0005829
comment: Reactome DB_ID: 3656754
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IJQ6
data source: Provenance1
name: eIF2B-delta
name: translation initiation factor 2B delta subunit
name: Q8IJQ6
name: eIF-2B GDP-GTP exchange factor, delta subunit
name: eIF-2B GDP-GTP exchange factor
name: Translation initiation factor eIF-2B delta subunit
xref: UnificationXref3815
feature: FragmentFeature705
cellular location: GO:0005829
comment: Reactome DB_ID: 3653380
display name: EIF2B4

http://identifiers.org/pubmed/16564093
type: PublicationXref
id: 16564093
author: Jacobsson, A
author: Jakobsson, A
author: Westerberg, R
db: Pubmed
title: Fatty acid elongases in mammals: their regulation and roles in metabolism
source: Prog Lipid Res 45:237-49
year: 2006

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I5R6
data source: Provenance1
name: eIF-2B GDP-GTP exchange factor, epsilon subunit
name: eIF2B-epsilon
name: Translation initiation factor eIF-2B epsilon subunit
name: EIF2B5(2-721)
name: eIF-2B GDP-GTP exchange factor
name: translation initiation factor 2B epsilon subunit
xref: UnificationXref3813
feature: FragmentFeature704
cellular location: GO:0005829
comment: Reactome DB_ID: 3653384
display name: Q8I5R6

http://identifiers.org/pubmed/5789664
type: PublicationXref
id: 5789664
author: Thomas, DP
author: Niewiarowski, S
db: Pubmed
title: Platelet factor 4 and adenosine diphosphate release during human platelet aggregation
source: Nature 222:1269-70
year: 1969

Translation initiation factor eIF-2B gamma subunit
type: Protein
entity reference: C0H5D7
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: eIF-2B GDP-GTP exchange factor, gamma subunit
name: eIF-2B GDP-GTP exchange factor
name: translation initiation factor 2B gamma subunit
name: eIF2B-gamma
name: C0H5D7
xref: UnificationXref3811
feature: FragmentFeature703
cellular location: GO:0005829
comment: Reactome DB_ID: 3653388
display name: EIF2B3

RelationshipXref30
type: RelationshipXref
id: GO:0017081
db: GENE ONTOLOGY
relationship type: MI:0355

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I4S8
data source: Provenance1
name: Q8I4S8
name: translation initiation factor 2B beta subunit
name: eIF-2B GDP-GTP exchange factor, beta subunit
name: eIF2B-beta
name: S20I15
name: eIF-2B GDP-GTP exchange factor
name: S20III15
name: Translation initiation factor eIF-2B beta subunit
xref: UnificationXref3808
feature: FragmentFeature702
cellular location: GO:0005829
comment: Reactome DB_ID: 3653376
display name: EIF2B2

RelationshipXref31
type: RelationshipXref
id: 3655501
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655501

UnificationXref211
type: UnificationXref
id: 3657240
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657240

UnificationXref212
type: UnificationXref
id: REACT_118181
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118181.7

UnificationXref213
type: UnificationXref
id: 3657294
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657294

UnificationXref214
type: UnificationXref
id: REACT_154903
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154903.3

translation initiation factor 5B
type: Protein
entity reference: C6KSR8
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: C6KSR8
name: eIF5B
xref: UnificationXref3794
feature: FragmentFeature701
cellular location: GO:0005829
comment: Reactome DB_ID: 3653588
display name: EIF5B

UnificationXref215
type: UnificationXref
id: 3657233
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657233

UnificationXref216
type: UnificationXref
id: REACT_114543
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114543.8

phospho-p-S318-PDE3B
type: Protein
entity reference: B3FEM7
data source: Provenance1
xref: UnificationXref3745
feature: FragmentFeature699
feature: ModificationFeature41
cellular location: GO:0005829
comment: Reactome DB_ID: 3654531

UnificationXref217
type: UnificationXref
id: 3657234
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657234

eIF5
type: Protein
entity reference: UniProt:Q8I5X8
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8I5X8
name: eukaryotic translation initiation factor 5
name: Eukaryotic translation initiation factor 5
name: eIF-5
xref: UnificationXref3788
feature: FragmentFeature700
cellular location: GO:0005829
comment: Reactome DB_ID: 3653364
display name: EIF5

UnificationXref218
type: UnificationXref
id: REACT_112661
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112661.8

RelationshipXref29
type: RelationshipXref
id: GO:0031018
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1860
type: UnificationXref
id: REACT_9725
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9725.2

UnificationXref1861
type: UnificationXref
id: CHEBI:17211
db: ChEBI

UnificationXref1862
type: UnificationXref
id: 191409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191409

UnificationXref1863
type: UnificationXref
id: REACT_9593
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9593.2

UnificationXref210
type: UnificationXref
id: REACT_114965
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114965.8

UnificationXref1864
type: UnificationXref
id: Q8II79
db: UniProt

RelationshipXref23
type: RelationshipXref
id: 3657012
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657012

UnificationXref1868
type: UnificationXref
id: 3654835
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654835

RelationshipXref24
type: RelationshipXref
id: GO:0051990
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1867
type: UnificationXref
id: 3654834
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654834

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I4W4
data source: Provenance1
name: Q8I4W4
name: SRP Receptor subunit beta
xref: UnificationXref3851
feature: FragmentFeature710
cellular location: GO:0005789
comment: Reactome DB_ID: 3656696
display name: SRPRB

RelationshipXref21
type: RelationshipXref
id: GO:0030203
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1866
type: UnificationXref
id: Q86GK8
db: UniProt

Chromosome Maintenance
type: Pathway
data source: Provenance1
pathway component: Maintenance of Telomeres
evidence: Evidence624
xref: UnificationXref5065
xref: UnificationXref5064
pathway order: PathwayStep607
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref22
type: RelationshipXref
id: GO:0070290
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1865
type: UnificationXref
id: 3654832
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654832

RelationshipXref27
type: RelationshipXref
id: 3656125
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656125

RelationshipXref28
type: RelationshipXref
id: GO:0007411
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref25
type: RelationshipXref
id: 3656170
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656170

RelationshipXref26
type: RelationshipXref
id: GO:0006103
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1869
type: UnificationXref
id: 3654836
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654836

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I2V7
data source: Provenance1
name: AGER1
name: Ost48
name: Q8I2V7
xref: UnificationXref3874
feature: FragmentFeature715
cellular location: GO:0005789
comment: Reactome DB_ID: 3656789
display name: DDOST

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IDN6
data source: Provenance1
name: Protein transport protein Sec61 subunit alpha isoform 1
name: S61A1_HUMAN
name: SEC61A1
xref: UnificationXref3867
feature: FragmentFeature714
cellular location: GO:0005789
comment: Reactome DB_ID: 3656785
display name: Q8IDN6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I3A5
data source: Provenance1
name: Q8I3A5
xref: UnificationXref3893
feature: FragmentFeature717
cellular location: GO:0005789
comment: Reactome DB_ID: 3656819
display name: SPCS3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8ILC7
data source: Provenance1
name: Q8ILC7
xref: UnificationXref3890
feature: FragmentFeature716
cellular location: GO:0005789
comment: Reactome DB_ID: 3656814
display name: SPCS1

UnificationXref219
type: UnificationXref
id: 3657235
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657235

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O96183
data source: Provenance1
name: O96183
name: SEC61 gamma
xref: UnificationXref3863
feature: FragmentFeature712
cellular location: GO:0005789
comment: Reactome DB_ID: 3656779
display name: SEC61G

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8ID42
data source: Provenance1
name: Q8ID42
name: SRP Receptor subunit alpha
xref: UnificationXref3853
feature: FragmentFeature711
cellular location: GO:0005789
comment: Reactome DB_ID: 3656732
display name: SRPR

RelationshipXref20
type: RelationshipXref
id: GO:0030212
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/22952392
type: PublicationXref
id: 22952392
author: Nusse, Roel
author: Willert, Karl
db: Pubmed
title: Wnt proteins
source: Cold Spring Harb Perspect Biol 4:a007864
year: 2012

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O60992
data source: Provenance1
name: Protein transport protein Sec61 subunit alpha isoform 1
name: S61A1_HUMAN
name: SEC61A1
xref: UnificationXref3865
feature: FragmentFeature713
cellular location: GO:0005789
comment: Reactome DB_ID: 3656783
display name: O60992

Homologues of SEC61A1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3868
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656786

UnificationXref224
type: UnificationXref
id: 2160848
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2160848

UnificationXref225
type: UnificationXref
id: REACT_124014
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124014.2

UnificationXref222
type: UnificationXref
id: REACT_136063
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136063.5

UnificationXref223
type: UnificationXref
id: GO:0005576
db: GENE ONTOLOGY

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IKX4
data source: Provenance1
name: Q8IKX4
xref: UnificationXref3840
feature: FragmentFeature708
cellular location: GO:0005829
comment: Reactome DB_ID: 3656758
display name: SRP54

UnificationXref228
type: UnificationXref
id: D0QEU4
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:F2X1X8
data source: Provenance1
name: F2X1X8
xref: UnificationXref3842
feature: FragmentFeature709
cellular location: GO:0005829
comment: Reactome DB_ID: 3656760
display name: SRP54

UnificationXref229
type: UnificationXref
id: 3656480
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656480

UnificationXref226
type: UnificationXref
id: Q8I5C7
db: UniProt

UnificationXref227
type: UnificationXref
id: 3656479
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656479

UnificationXref1870
type: UnificationXref
id: 3654837
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654837

UnificationXref1871
type: UnificationXref
id: 3654841
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654841

RelationshipXref19
type: RelationshipXref
id: GO:0030213
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref18
type: RelationshipXref
id: 3656947
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656947

UnificationXref220
type: UnificationXref
id: REACT_113367
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113367.8

UnificationXref1874
type: UnificationXref
id: 191385
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191385

UnificationXref221
type: UnificationXref
id: 3657236
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657236

UnificationXref1875
type: UnificationXref
id: REACT_9889
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9889.2

UnificationXref1872
type: UnificationXref
id: REACT_89249
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89249.9

UnificationXref1873
type: UnificationXref
id: CHEBI:17407
db: ChEBI

RelationshipXref14
type: RelationshipXref
id: GO:0000165
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref15
type: RelationshipXref
id: GO:0007173
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref16
type: RelationshipXref
id: GO:0008543
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref17
type: RelationshipXref
id: GO:0008514
db: GENE ONTOLOGY
relationship type: MI:0355

Q8IE14
type: Protein
entity reference: Q8IE14
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3897
feature: FragmentFeature719
cellular location: GO:0005789
comment: Reactome DB_ID: 3656808
display name: SEC11C

RelationshipXref10
type: RelationshipXref
id: GO:0008294
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1877
type: UnificationXref
id: REACT_87629
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87629.9

Q2V8J6
type: Protein
entity reference: Q2V8J6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3895
feature: FragmentFeature718
cellular location: GO:0005789
comment: Reactome DB_ID: 3656807
display name: SEC11C

RelationshipXref11
type: RelationshipXref
id: 3654359
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654359

UnificationXref1876
type: UnificationXref
id: 3654839
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654839

RelationshipXref12
type: RelationshipXref
id: GO:0034199
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1879
type: UnificationXref
id: REACT_34689
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34689.10

RelationshipXref13
type: RelationshipXref
id: GO:0007165
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1878
type: UnificationXref
id: 3657377
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657377

Q8IE14
type: Protein
entity reference: Q8IE14
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3902
feature: FragmentFeature722
cellular location: GO:0005789
comment: Reactome DB_ID: 3656803
display name: SEC11A

Q2V8J6
type: Protein
entity reference: Q2V8J6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3901
feature: FragmentFeature721
cellular location: GO:0005789
comment: Reactome DB_ID: 3656801
display name: SEC11A

Homologues of SEC11A
type: Protein
data source: Provenance1
member physical entity: Q8IE14
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q2V8J6
xref: UnificationXref3904
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656806

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q2V8J7
data source: Provenance1
name: Q2V8J7
xref: UnificationXref3899
feature: FragmentFeature720
cellular location: GO:0005789
comment: Reactome DB_ID: 3656809
display name: SEC11C

http://identifiers.org/pubmed/5324173
type: PublicationXref
id: 5324173
author: Berg, P
author: Baldwin, AN
db: Pubmed
title: Transfer ribonucleic acid-induced hydrolysis of valyladenylate bound to isoleucyl ribonucleic acid synthetase
source: J Biol Chem 241:839-45
year: 1966

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q9NDT2
data source: Provenance1
name: eEF2
name: Q9NDT2
xref: UnificationXref3993
feature: FragmentFeature725
cellular location: GO:0005829
comment: Reactome DB_ID: 3654503
display name: EEF2

Homologues of EEF2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3996
cellular location: GO:0005829
comment: Reactome DB_ID: 3654506
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I0P6
data source: Provenance1
name: EEF1A1
name: Q8I0P6
xref: UnificationXref3911
feature: FragmentFeature724
cellular location: GO:0005829
comment: Reactome DB_ID: 3654464
display name: eEF1A

http://identifiers.org/pubmed/5324172
type: PublicationXref
id: 5324172
author: Berg, P
author: Baldwin, AN
db: Pubmed
title: Purification and properties of isoleucyl ribonucleic acid synthetase from Escherichia coli
source: J Biol Chem 241:831-8
year: 1966

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q2V8J7
data source: Provenance1
name: Q2V8J7
xref: UnificationXref3903
feature: FragmentFeature723
cellular location: GO:0005789
comment: Reactome DB_ID: 3656805
display name: SEC11A

UnificationXref237
type: UnificationXref
id: 3656484
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656484

UnificationXref238
type: UnificationXref
id: D0QEW0
db: UniProt

Homologues of SEC11C
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q8IE14
member physical entity: Q2V8J6
xref: UnificationXref3900
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656810

UnificationXref239
type: UnificationXref
id: 3656485
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656485

UnificationXref233
type: UnificationXref
id: 3656482
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656482

UnificationXref234
type: UnificationXref
id: D0QEV8
db: UniProt

http://identifiers.org/pubmed/18802415
type: PublicationXref
id: 18802415
author: Ko, CH
author: Takahashi, JS
author: Hong, HK
author: McDearmon, EL
db: Pubmed
title: The genetics of mammalian circadian order and disorder: implications for physiology and disease
source: Nat Rev Genet 9:764-75
year: 2008

UnificationXref235
type: UnificationXref
id: 3656483
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656483

UnificationXref236
type: UnificationXref
id: D0QEU0
db: UniProt

UnificationXref1883
type: UnificationXref
id: CHEBI:16330
db: ChEBI

UnificationXref230
type: UnificationXref
id: D0QEU6
db: UniProt

UnificationXref1884
type: UnificationXref
id: 469662
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=469662

UnificationXref231
type: UnificationXref
id: 3656481
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656481

UnificationXref1885
type: UnificationXref
id: REACT_23239
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23239.2

UnificationXref232
type: UnificationXref
id: D0QF37
db: UniProt

UnificationXref1886
type: UnificationXref
id: C6S3J5
db: UniProt

UnificationXref1880
type: UnificationXref
id: CHEBI:17347
db: ChEBI

UnificationXref1881
type: UnificationXref
id: 193057
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193057

UnificationXref1882
type: UnificationXref
id: REACT_10360
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10360.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IKW5
data source: Provenance1
name: eEF2
name: Q8IKW5
xref: UnificationXref3995
feature: FragmentFeature726
cellular location: GO:0005829
comment: Reactome DB_ID: 3654505
display name: EEF2

UnificationXref1889
type: UnificationXref
id: REACT_134854
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134854.5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I320
data source: Provenance1
name: Elongation factor 1-delta
name: EF-1-delta
name: eEF1B delta
name: Q8I320
xref: UnificationXref4006
feature: FragmentFeature727
cellular location: GO:0005829
comment: Reactome DB_ID: 3654483
display name: EEF1D

UnificationXref1888
type: UnificationXref
id: 3655990
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655990

Homologues of EEF1D
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4011
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654486

UnificationXref1887
type: UnificationXref
id: 3655988
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655988

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O97319
data source: Provenance1
name: Elongation factor 1-delta
name: O97319
name: EF-1-delta
name: eEF1B delta
xref: UnificationXref4010
feature: FragmentFeature729
cellular location: GO:0005829
comment: Reactome DB_ID: 3654485
display name: EEF1D

http://identifiers.org/pubmed/1592113
type: PublicationXref
id: 1592113
author: Powell, SM
author: Dixon, JE
author: Zalkin, H
db: Pubmed
title: Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase
source: FEBS Lett 303:4-20
year: 1992

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9NI00
data source: Provenance1
name: Q9NI00
name: Elongation factor 1-delta
name: EF-1-delta
name: eEF1B delta
xref: UnificationXref4008
feature: FragmentFeature728
cellular location: GO:0005829
comment: Reactome DB_ID: 3654484
display name: EEF1D

http://identifiers.org/pubmed/15526160
type: PublicationXref
id: 15526160
author: Rönnstrand, L
db: Pubmed
title: Signal transduction via the stem cell factor receptor/c-Kit
source: Cell Mol Life Sci 61:2535-48
year: 2004

EF-1-beta
type: Protein
entity reference: Q8I320
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: eEF1B beta
name: Elongation factor 1-beta
name: Q8I320
xref: UnificationXref4012
feature: FragmentFeature730
cellular location: GO:0005829
comment: Reactome DB_ID: 3654475
display name: EEF1B2

Homologues of EEF1B2
type: Protein
data source: Provenance1
member physical entity: EF-1-beta
xref: UnificationXref4015
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654482

EF-1-beta
type: Protein
entity reference: UniProt:O97319
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: O97319
name: eEF1B beta
name: Elongation factor 1-beta
xref: UnificationXref4014
feature: FragmentFeature732
cellular location: GO:0005829
comment: Reactome DB_ID: 3654481
display name: EEF1B2

EF-1-beta
type: Protein
entity reference: Q9NI00
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q9NI00
name: eEF1B beta
name: Elongation factor 1-beta
xref: UnificationXref4013
feature: FragmentFeature731
cellular location: GO:0005829
comment: Reactome DB_ID: 3654477
display name: EEF1B2

Elongation factor 1-gamma
type: Protein
entity reference: Q8IDV0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8IDV0
name: eEF1B gamma
name: EF-1-gamma
xref: UnificationXref4017
feature: FragmentFeature733
cellular location: GO:0005829
comment: Reactome DB_ID: 3654490
display name: EEF1G

UnificationXref248
type: UnificationXref
id: D0QEY8
db: UniProt

UnificationXref249
type: UnificationXref
id: 3656490
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656490

UnificationXref246
type: UnificationXref
id: D0QF08
db: UniProt

UnificationXref247
type: UnificationXref
id: 3656489
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656489

UnificationXref244
type: UnificationXref
id: D0QF04
db: UniProt

UnificationXref245
type: UnificationXref
id: 3656488
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656488

UnificationXref242
type: UnificationXref
id: D0QF32
db: UniProt

UnificationXref1896
type: UnificationXref
id: CHEBI:57560
db: ChEBI

UnificationXref243
type: UnificationXref
id: 3656487
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656487

UnificationXref1897
type: UnificationXref
id: 1524021
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524021

UnificationXref240
type: UnificationXref
id: D0QEY2
db: UniProt

UnificationXref1894
type: UnificationXref
id: 1500594
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500594

UnificationXref241
type: UnificationXref
id: 3656486
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656486

UnificationXref1895
type: UnificationXref
id: REACT_125604
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125604.1

UnificationXref1892
type: UnificationXref
id: 3657469
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657469

photoreceptor outer segment membrane
type: CellularLocationVocabulary
xref: UnificationXref325

UnificationXref1893
type: UnificationXref
id: REACT_97355
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97355.9

UnificationXref1890
type: UnificationXref
id: 3657468
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657468

UnificationXref1891
type: UnificationXref
id: REACT_33719
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33719.10

RelationshipXref71
type: RelationshipXref
id: GO:0033572
db: GENE ONTOLOGY
relationship type: MI:0359

UniProt:Q8IBK9
type: ProteinReference
xref: UnificationXref2333
organism: BioSource1

RelationshipXref70
type: RelationshipXref
id: 3653886
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3653886

RelationshipXref73
type: RelationshipXref
id: GO:0004012
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref72
type: RelationshipXref
id: GO:0006879
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref75
type: RelationshipXref
id: GO:0034220
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref74
type: RelationshipXref
id: 3656251
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656251

RelationshipXref77
type: RelationshipXref
id: GO:0000288
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1898
type: UnificationXref
id: REACT_125305
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125305.1

RelationshipXref76
type: RelationshipXref
id: GO:0043928
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1899
type: UnificationXref
id: 1500596
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500596

RelationshipXref79
type: RelationshipXref
id: 3652675
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652675

http://identifiers.org/pubmed/11502751
type: PublicationXref
id: 11502751
author: Nagata, E
author: Luo, HR
author: Saiardi, A
author: Snowman, AM
author: Snyder, SH
db: Pubmed
title: Identification and characterization of a novel inositol hexakisphosphate kinase
source: J Biol Chem 276:39179-85
year: 2001

http://identifiers.org/pubmed/18400693
type: PublicationXref
id: 18400693
author: Dorwart, MR
author: Muallem, S
author: Yang, D
author: Shcheynikov, N
db: Pubmed
title: The solute carrier 26 family of proteins in epithelial ion transport
source: Physiology (Bethesda) 23:104-14
year: 2008

RelationshipXref78
type: RelationshipXref
id: GO:0004175
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref60
type: RelationshipXref
id: GO:0005385
db: GENE ONTOLOGY
relationship type: MI:0355

eIF-4A-I
type: Protein
entity reference: Q8IKF0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: eukaryotic initiation factor 4A-I
name: Q8IKF0
name: Eukaryotic initiation factor 4A-I
name: eIF4A-I
name: EIF4A1(1-406)
xref: UnificationXref3667
feature: FragmentFeature676
cellular location: GO:0005829
comment: Reactome DB_ID: 3653346
display name: eIF4AI

eIF-4A-I
type: Protein
entity reference: UniProt:O97223
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: eukaryotic initiation factor 4A-I
name: O97223
name: Eukaryotic initiation factor 4A-I
name: eIF4A-I
name: EIF4A1(1-406)
xref: UnificationXref3668
feature: FragmentFeature677
cellular location: GO:0005829
comment: Reactome DB_ID: 3653348
display name: eIF4AI

UniProt:Q8IBJ9
type: ProteinReference
xref: UnificationXref1197
organism: BioSource1

translation initiation factor 2 alpha subunit
type: Protein
entity reference: UniProt:Q8IBH7
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8IBH7
name: EIF-2A
name: eIF-2-alpha
name: EIF- 2alpha
name: Eukaryotic translation initiation factor 2 subunit 1
name: eIF2-alpha
name: translation initiation factor 2, subunit 1
name: Eukaryotic translation initiation factor 2 alpha subunit
name: EIF2S1(2-315)
xref: UnificationXref3675
feature: FragmentFeature678
cellular location: GO:0005829
comment: Reactome DB_ID: 3653327
display name: EIF2S1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8ILY9
data source: Provenance1
name: Eukaryotic translation initiation factor 2 gamma subunit
name: eukaryotic translation initiation factor 2, subunit 3
name: Eukaryotic translation initiation factor 2 subunit 3
name: Q8ILY9
name: eIF-2-gamma
name: eIF2-gamma
name: eukaryotic translation initiation factor 2 gamma subunit
xref: UnificationXref3677
feature: FragmentFeature679
cellular location: GO:0005829
comment: Reactome DB_ID: 3653335
display name: EIF2S3

RelationshipXref64
type: RelationshipXref
id: GO:0015307
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/7544491
type: PublicationXref
id: 7544491
author: Yu, J
author: Allsopp, RC
author: Chiu, CP
author: Funk, WD
author: Avilion, AA
author: Feng, J
author: Chang, E
author: Adams, RR
author: Weinrich, SL
author: Wang, SS
db: Pubmed
title: The RNA component of human telomerase
source: Science 269:1236-41
year: 1995

RelationshipXref63
type: RelationshipXref
id: 3655829
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655829

RelationshipXref62
type: RelationshipXref
id: 3655824
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655824

http://identifiers.org/pubmed/2462567
type: PublicationXref
id: 2462567
author: de Jong, WW
author: Stapel, SO
author: Lietman, T
author: Wistow, GJ
author: Piatigorsky, J
author: Williams, LA
author: Horwitz, J
db: Pubmed
title: Tau-crystallin/alpha-enolase: one gene encodes both an enzyme and a lens structural protein
source: J Cell Biol 107:2729-36
year: 1988

RelationshipXref61
type: RelationshipXref
id: 3655819
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655819

eIF-4A-I
type: Protein
entity reference: Q2PZH3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: eukaryotic initiation factor 4A-I
name: Q2PZH3
name: Eukaryotic initiation factor 4A-I
name: eIF4A-I
name: EIF4A1(1-406)
xref: UnificationXref3666
feature: FragmentFeature675
cellular location: GO:0005829
comment: Reactome DB_ID: 3653344
display name: eIF4AI

RelationshipXref68
type: RelationshipXref
id: GO:0005457
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref67
type: RelationshipXref
id: 3656131
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656131

RelationshipXref66
type: RelationshipXref
id: GO:0008521
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref65
type: RelationshipXref
id: 3656116
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656116

RelationshipXref69
type: RelationshipXref
id: 3656137
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656137

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8I5Y3
data source: Provenance1
name: eIF3c
name: eukaryotic translation initiation factor 3 subunit 8
name: eIF3 p110
name: Eukaryotic translation initiation factor 3 subunit 8
name: Q8I5Y3
xref: UnificationXref3695
feature: FragmentFeature685
cellular location: GO:0005829
comment: Reactome DB_ID: 3653310
display name: EIF3C

RelationshipXref51
type: RelationshipXref
id: GO:0008645
db: GENE ONTOLOGY
relationship type: MI:0359

UniProt:Q8IBI5
type: ProteinReference
xref: UnificationXref3189
organism: BioSource1

Q8I2X0
type: Protein
entity reference: Q8I2X0
data source: Provenance1
name: eukaryotic translation initiation factor 3 subunit 5
name: Note: the coordinates are copied over from Homo sapiens.
name: eIF3 p47
name: eIF3 p47 subunit
name: eIF3f
name: Eukaryotic translation initiation factor 3 subunit 5
name: eIF-3 epsilon
name: eIF3-epsilon
xref: UnificationXref3697
feature: FragmentFeature686
cellular location: GO:0005829
comment: Reactome DB_ID: 3653296
display name: EIF3F

RelationshipXref50
type: RelationshipXref
id: GO:0015758
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/12324224
type: PublicationXref
id: 12324224
author: Sprecher, H
db: Pubmed
title: The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids
source: Prostaglandins Leukot Essent Fatty Acids 67:79-83
year: 2002

RelationshipXref53
type: RelationshipXref
id: 3655725
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655725

UniProt:Q8IBI3
type: ProteinReference
xref: UnificationXref877
organism: BioSource1

RelationshipXref52
type: RelationshipXref
id: GO:0055056
db: GENE ONTOLOGY
relationship type: MI:0355

Eukaryotic translation initiation factor 3 subunit 4
type: Protein
entity reference: UniProt:Q8IAZ3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: eIF3g
name: eukaryotic translation initiation factor 3 subunit 4
name: eIF3 p42
name: eIF3 p44
name: eIF-3 delta
name: eIF-3 RNA-binding subunit
name: eIF3-delta
name: Q8IAZ3
xref: UnificationXref3703
feature: FragmentFeature689
cellular location: GO:0005829
comment: Reactome DB_ID: 3653292
display name: EIF3G

Phagosomal maturation (early endosomal stage)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1
pathway component: BiochemicalReaction2
evidence: Evidence3
xref: RelationshipXref6
xref: UnificationXref99
xref: UnificationXref100
pathway order: PathwayStep1
pathway order: PathwayStep2
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

phospho-p-RPL13A
type: Protein
entity reference: Q8IJZ7
data source: Provenance1
xref: UnificationXref3707
feature: ModificationFeature38
feature: FragmentFeature690
cellular location: GO:0005829
comment: Reactome DB_ID: 3654445

eukaryotic translation initiation factor 3 subunit 9
type: Protein
entity reference: Q8I3T1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: eIF3b
name: eIF3 p110
name: Q8I3T1
name: eIF-3 eta
name: Eukaryotic translation initiation factor 3 subunit 9
name: eIF3 p116
name: eIF3-eta
xref: UnificationXref3699
feature: FragmentFeature687
cellular location: GO:0005829
comment: Reactome DB_ID: 3653300
display name: EIF3B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I3I5
data source: Provenance1
name: eukaryotic translation initiation factor 3 subunit 6
name: Mammary tumor-associated protein INT-6
name: Q8I3I5
name: eIF3e
name: Eukaryotic translation initiation factor 3 subunit 6
name: eIF-3 p48
name: Viral integration site protein INT-6
xref: UnificationXref3701
feature: FragmentFeature688
cellular location: GO:0005829
comment: Reactome DB_ID: 3653314
display name: EIF3E

RelationshipXref59
type: RelationshipXref
id: 3655810
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655810

RelationshipXref58
type: RelationshipXref
id: GO:0005381
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/17127307
type: PublicationXref
id: 17127307
author: Luckashenak, N
author: Clements, JL
db: Pubmed
title: Signaling mechanisms utilized by antigen receptors and integrins: common intermediates, different outcomes?
source: Front Biosci 12:419-36
year: 2007

RelationshipXref55
type: RelationshipXref
id: 3655722
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655722

RelationshipXref54
type: RelationshipXref
id: GO:0051119
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref57
type: RelationshipXref
id: 3655730
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655730

RelationshipXref56
type: RelationshipXref
id: GO:0022857
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/11533233
type: PublicationXref
id: 11533233
author: Fox, PL
author: Sonenberg, N
author: Imataka, H
author: Seshadri, V
author: Mazumder, B
db: Pubmed
title: Translational silencing of ceruloplasmin requires the essential elements of mRNA circularization: poly(A) tail, poly(A)-binding protein, and eukaryotic translation initiation factor 4G
source: Mol Cell Biol 21:6440-9
year: 2001

Q9NFE6
type: Protein
entity reference: Q9NFE6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ARG134
name: eIF-3 p25
name: PTD001
name: HSPC029
name: eukaryotic translation initiation factor 3 subunit 11
name: eIF3k
name: Eukaryotic translation initiation factor 3 subunit 11
name: Muscle specific gene M9 protein
xref: UnificationXref3690
feature: FragmentFeature683
cellular location: GO:0005829
comment: Reactome DB_ID: 3653318
display name: EIF3K

http://identifiers.org/pubmed/9741684
type: PublicationXref
id: 9741684
author: Edwards, PA
author: Shell, BK
author: Greene, JM
author: Ericsson, J
author: Carter, KC
author: Florence, C
author: Duan, DR
db: Pubmed
title: Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression
source: J Lipid Res 39:1731-9
year: 1998

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IJW4
data source: Provenance1
name: eukaryotic translation initiation factor 3 subunit 7
name: eIF3 p66
name: eIF3d
name: Eukaryotic translation initiation factor 3 subunit 7
name: eIF-3 zeta
name: eIF3-zeta
name: Q8IJW4
xref: UnificationXref3687
feature: FragmentFeature682
cellular location: GO:0005829
comment: Reactome DB_ID: 3653306
display name: EIF3D

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IHT2
data source: Provenance1
name: EIF1AX(2-144)
name: eIF-1A X isoform
name: Eukaryotic translation initiation factor 1A, X-chromosomal
name: eIF-4C
name: Q8IHT2
name: eukaryotic translation initiation factor 1A
name: eIF-1A
xref: UnificationXref3684
feature: FragmentFeature681
cellular location: GO:0005829
comment: Reactome DB_ID: 3653323
display name: eIF1A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IJT9
data source: Provenance1
name: eukaryotic translation initiation factor 2, subunit 2
name: Eukaryotic translation initiation factor 2 subunit 2
name: EIF2S2(1-333)
name: eukaryotic translation initiation factor 2 beta subunit
name: Eukaryotic translation initiation factor 2 beta subunit
name: eIF-2-beta
name: eIF2-beta
xref: UnificationXref3679
feature: FragmentFeature680
cellular location: GO:0005829
comment: Reactome DB_ID: 3653331
display name: Q8IJT9

UniProt:Q8MV47
type: ProteinReference
xref: UnificationXref4499
organism: BioSource1

eIF-3 beta
type: Protein
entity reference: UniProt:Q8IBT2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Eukaryotic translation initiation factor 3 subunit 2
name: eukaryotic translation initiation factor 3 subunit 2
name: eIF3-beta
name: TGF-beta receptor interacting protein 1
name: eIF3i
name: TRIP-1
name: eIF3 p36
name: Q8IBT2
xref: UnificationXref3692
feature: FragmentFeature684
cellular location: GO:0005829
comment: Reactome DB_ID: 3653288
display name: EIF3I

RelationshipXref42
type: RelationshipXref
id: GO:0015149
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/19021507
type: PublicationXref
id: 19021507
author: Johnson, MK
author: Chandramouli, K
author: Bandyopadhyay, S
db: Pubmed
title: Iron-sulfur cluster biosynthesis
source: Biochem Soc Trans 36:1112-9
year: 2008

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IJ32
data source: Provenance1
name: DNM1L
name: Q8IJ32
xref: UnificationXref3727
feature: FragmentFeature694
cellular location: GO:0005829
comment: Reactome DB_ID: 3655284
display name: Drp1

RelationshipXref41
type: RelationshipXref
id: 3654748
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654748

Homologues of DNM1L
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3731
cellular location: GO:0005741
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655288

RelationshipXref40
type: RelationshipXref
id: GO:0005353
db: GENE ONTOLOGY
relationship type: MI:0355

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6KF55
data source: Provenance1
name: DNM1L
name: Q6KF55
xref: UnificationXref3729
feature: FragmentFeature695
cellular location: GO:0005741
comment: Reactome DB_ID: 3655286
display name: Drp1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IJ32
data source: Provenance1
name: DNM1L
name: Q8IJ32
xref: UnificationXref3730
feature: FragmentFeature696
cellular location: GO:0005741
comment: Reactome DB_ID: 3655287
display name: Drp1

Homologues of p-S318-PDE3B
type: Protein
data source: Provenance1
member physical entity: phospho-p-S318-PDE3B
xref: UnificationXref3746
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654532

UniProt:Q8IBH7
type: ProteinReference
xref: UnificationXref3674
organism: BioSource1

phospho-p-S318-PDE3B
type: Protein
entity reference: Q8IKD3
data source: Provenance1
xref: UnificationXref3741
feature: ModificationFeature39
feature: FragmentFeature697
cellular location: GO:0005829
comment: Reactome DB_ID: 3654527

phospho-p-S318-PDE3B
type: Protein
entity reference: UniProt:Q8I6Z7
data source: Provenance1
xref: UnificationXref3743
feature: FragmentFeature698
feature: ModificationFeature40
cellular location: GO:0005829
comment: Reactome DB_ID: 3654529

RelationshipXref49
type: RelationshipXref
id: GO:0010827
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref48
type: RelationshipXref
id: 3652842
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652842

RelationshipXref47
type: RelationshipXref
id: GO:0004340
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref46
type: RelationshipXref
id: 3655914
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655914

RelationshipXref45
type: RelationshipXref
id: 3652833
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652833

RelationshipXref44
type: RelationshipXref
id: GO:0005355
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref43
type: RelationshipXref
id: 3654750
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654750

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IM53
data source: Provenance1
name: Q8IM53
name: Cytochrome c
xref: UnificationXref3717
feature: FragmentFeature692
cellular location: GO:0005829
comment: Reactome DB_ID: 3654385
display name: CYCS

UnificationXref207
type: UnificationXref
id: 3657292
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657292

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IM53
data source: Provenance1
name: Q8IM53
name: Cytochrome c
xref: UnificationXref3716
feature: FragmentFeature691
cellular location: GO:0005758
comment: Reactome DB_ID: 3654386
display name: CYCS

UnificationXref206
type: UnificationXref
id: REACT_156932
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156932.3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6KF55
data source: Provenance1
name: DNM1L
name: Q6KF55
xref: UnificationXref3725
feature: FragmentFeature693
cellular location: GO:0005829
comment: Reactome DB_ID: 3655282
display name: Drp1

UnificationXref205
type: UnificationXref
id: 3657291
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657291

Homologues of DNM1L
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3728
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655285

UnificationXref204
type: UnificationXref
id: REACT_157443
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157443.3

Phase II conjugation
type: Pathway
data source: Provenance1
pathway component: REACT 94161.9
evidence: Evidence418
xref: UnificationXref3589
xref: UnificationXref3590
xref: RelationshipXref444
pathway order: PathwayStep412
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref203
type: UnificationXref
id: 3657275
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657275

UnificationXref202
type: UnificationXref
id: REACT_152916
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152916.3

UnificationXref201
type: UnificationXref
id: 3657274
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657274

http://identifiers.org/pubmed/16968945
type: PublicationXref
id: 16968945
author: Kontush, A
author: Chapman, MJ
db: Pubmed
title: Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis
source: Pharmacol Rev 58:342-74
year: 2006

UnificationXref200
type: UnificationXref
id: REACT_159307
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159307.3

UniProt:Q8IC16
type: ProteinReference
xref: UnificationXref4926
organism: BioSource1

Phosphoenolpyruvic acid
type: SmallMoleculeReference
name: Phosphoenolpyruvate
name: Phosphoenolpyruvate [ChEBI:18021]
name: PEP
xref: UnificationXref1308

UniProt:Q8IC11
type: ProteinReference
xref: UnificationXref5675
organism: BioSource1

UniProt:Q8IBP3
type: ProteinReference
xref: UnificationXref2980
organism: BioSource1

SequenceSite314
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite315
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite316
type: SequenceSite
position status: EQUAL
sequence position: 1

Calmodulin induced events
type: Pathway
data source: Provenance1
pathway component: PKA-mediated phosphorylation of CREB
evidence: Evidence10
xref: UnificationXref183
xref: UnificationXref182
pathway order: PathwayStep9
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite317
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite318
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite319
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite310
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q8IC08
type: ProteinReference
xref: UnificationXref4578
organism: BioSource1

SequenceSite311
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite312
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite313
type: SequenceSite
position status: EQUAL
sequence position: 1325

diacylglycerols
type: SmallMoleculeReference
name: diacylglycerols [ChEBI:18035]
xref: UnificationXref110

SequenceSite327
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite328
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite325
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite326
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite329
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite320
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite323
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite324
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite321
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite322
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/20364103
type: PublicationXref
id: 20364103
author: Schoenmakers, S
author: Baarends, WM
author: Inagaki, A
db: Pubmed
title: DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis
source: Epigenetics 5:
year: 2010

UniProt:Q8IBN5
type: ProteinReference
xref: UnificationXref1066
organism: BioSource1

Stoichiometry8
type: Stoichiometry
physical entity: Protein9
stoichiometric coefficient: 1.0

Stoichiometry7
type: Stoichiometry
physical entity: Complex3
stoichiometric coefficient: 1.0

Stoichiometry9
type: Stoichiometry
physical entity: Protein12
stoichiometric coefficient: 1.0

PublicationXref266
type: PublicationXref
id: 0-87893-741-2
author: Purves, D
db: ISBN
title: Chapter 4: Channels and Transporters
source: Neuroscience (2nd ed.) (Book)
year: 2001

ChEBI:9532 thiamine(1+) diphosphate
type: SmallMoleculeReference
name: thiamine(1+) diphosphate
xref: UnificationXref3034

http://identifiers.org/pubmed/1706616
type: PublicationXref
id: 1706616
author: Ullrich, A
author: Hazan, R
author: Margolis, B
author: Zilberstein, A
author: Schlessinger, J
author: Dombalagian, M
db: Pubmed
title: Identification of autophosphorylation sites of HER2/neu
source: Cell Growth Differ 1:3-7
year: 1990

L-Glutamine
type: SmallMoleculeReference
name: L-Glutamine [ChEBI:18050]
name: L-2-Aminoglutaramic acid
xref: UnificationXref2531

http://identifiers.org/pubmed/17956313
type: PublicationXref
id: 17956313
author: Herbert, TP
db: Pubmed
title: PERK in the life and death of the pancreatic beta-cell
source: Biochem Soc Trans 35:1205-7
year: 2007

L-arginine removal
type: SequenceModificationVocabulary
xref: UnificationXref358

Stoichiometry1
type: Stoichiometry
physical entity: SmallMolecule1
stoichiometric coefficient: 3.0

SequenceSite309
type: SequenceSite
position status: EQUAL
sequence position: 1325

Stoichiometry2
type: Stoichiometry
physical entity: SmallMolecule2
stoichiometric coefficient: 3.0

SequenceSite307
type: SequenceSite
position status: EQUAL
sequence position: 1325

http://identifiers.org/pubmed/2805070
type: PublicationXref
id: 2805070
author: Morin, GB
db: Pubmed
title: The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
source: Cell 59:521-9
year: 1989

SequenceSite308
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry5
type: Stoichiometry
physical entity: Protein3
stoichiometric coefficient: 1.0

SequenceSite305
type: SequenceSite
position status: EQUAL
sequence position: 1325

http://identifiers.org/pubmed/9693067
type: PublicationXref
id: 9693067
author: Bader, B
author: Löffler, M
author: Fries, M
author: Knecht, W
db: Pubmed
title: Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase.
source: Protein Expr Purif 13:414-22
year: 1998

Stoichiometry6
type: Stoichiometry
physical entity: Protein6
stoichiometric coefficient: 3.0

SequenceSite306
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry3
type: Stoichiometry
physical entity: Protein1
stoichiometric coefficient: 1.0

SequenceSite303
type: SequenceSite
position status: EQUAL
sequence position: 1325

Stoichiometry4
type: Stoichiometry
physical entity: Protein2
stoichiometric coefficient: 1.0

SequenceSite304
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/17057362
type: PublicationXref
id: 17057362
author: Ying, SY
author: Miller, JD
author: Lin, SL
db: Pubmed
title: Intronic microRNA (miRNA)
source: J Biomed Biotechnol 2006:26818
year: 2006

SequenceSite301
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite302
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite300
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q8IBT2
type: ProteinReference
xref: UnificationXref3691
organism: BioSource1

SequenceSite360
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6ZLZ9
data source: Provenance1
name: TUBA4A unfolded
name: unfolded alpha tubulin -1
xref: UnificationXref4059
feature: FragmentFeature741
cellular location: GO:0005829
comment: Reactome DB_ID: 3655555
display name: Q6ZLZ9

SequenceSite351
type: SequenceSite
position status: EQUAL
sequence position: 1382

Homologues of TUBA1B unfolded
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4064
cellular location: GO:0005829
comment: Reactome DB_ID: 3655560
comment: Converted from EntitySet in Reactome

SequenceSite350
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite353
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite352
type: SequenceSite
position status: EQUAL
sequence position: 1

PFDN3
type: Protein
entity reference: UniProt:Q8IBR6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8IBR6
xref: UnificationXref4052
feature: FragmentFeature738
cellular location: GO:0005829
comment: Reactome DB_ID: 3655588
display name: VBP1

SequenceSite355
type: SequenceSite
position status: EQUAL
sequence position: 1382

http://identifiers.org/pubmed/20043944
type: PublicationXref
id: 20043944
author: Bankaitis, VA
author: Liu, Y
db: Pubmed
title: Phosphoinositide phosphatases in cell biology and disease
source: Prog Lipid Res 49:201-17
year: 2010

Homologues of TUBA4A unfolded
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4060
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655556

SequenceSite354
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q25790
data source: Provenance1
name: TUBA4A unfolded
name: unfolded alpha tubulin -1
xref: UnificationXref4055
feature: FragmentFeature739
cellular location: GO:0005829
comment: Reactome DB_ID: 3655549
display name: Q25790

SequenceSite357
type: SequenceSite
position status: EQUAL
sequence position: 1382

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IFP3
data source: Provenance1
name: TUBA4A unfolded
name: unfolded alpha tubulin -1
xref: UnificationXref4057
feature: FragmentFeature740
cellular location: GO:0005829
comment: Reactome DB_ID: 3655551
display name: Q8IFP3

SequenceSite356
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I3A4
data source: Provenance1
name: Q8I3A4
xref: UnificationXref4044
feature: FragmentFeature734
cellular location: GO:0005829
comment: Reactome DB_ID: 3655592
display name: PFDN4

SequenceSite359
type: SequenceSite
position status: EQUAL
sequence position: 1382

PFDN6(2-129)
type: Protein
entity reference: Q8I3Y6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8I3Y6
xref: UnificationXref4046
feature: FragmentFeature735
cellular location: GO:0005829
comment: Reactome DB_ID: 3655600
display name: PFDN6

SequenceSite358
type: SequenceSite
position status: EQUAL
sequence position: 1

Q8II82
type: Protein
entity reference: Q8II82
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PFDN5(2-154)
xref: UnificationXref4048
feature: FragmentFeature736
cellular location: GO:0005829
comment: Reactome DB_ID: 3655596
display name: PFDN5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8ILS7
data source: Provenance1
name: Q8ILS7
xref: UnificationXref4050
feature: FragmentFeature737
cellular location: GO:0005829
comment: Reactome DB_ID: 3655584
display name: PFDN2

UniProt:Q8IBS3
type: ProteinReference
xref: UnificationXref5364
organism: BioSource1

dTDP
type: SmallMoleculeReference
name: Deoxythymidine 5'-diphosphate
name: dTDP [ChEBI:18075]
xref: UnificationXref2832

TTP
type: SmallMoleculeReference
name: Deoxythymidine 5'-triphosphate
name: dTTP
name: Deoxythymidine triphosphate
name: dTTP [ChEBI:18077]
xref: UnificationXref2919

SequenceSite370
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite371
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite364
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite363
type: SequenceSite
position status: EQUAL
sequence position: 1382

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IFP3
data source: Provenance1
name: Tubulin alpha-3C/D chain
name: TUBA3C unfolded
name: Q8IFP3
name: unfolded alpha tubulin 2.2
name: TBA3C_HUMAN
xref: UnificationXref4070
feature: FragmentFeature749
cellular location: GO:0005829
comment: Reactome DB_ID: 3655566
display name: TUBA3C

SequenceSite362
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/15571818
type: PublicationXref
id: 15571818
author: Kloetzel, PM
db: Pubmed
title: The proteasome and MHC class I antigen processing
source: Biochim Biophys Acta 1695:225-33
year: 2004

SequenceSite361
type: SequenceSite
position status: EQUAL
sequence position: 1382

Homologues of TUBA3C unfolded
type: Protein
data source: Provenance1
member physical entity: Q25790
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q6ZLZ9
xref: UnificationXref4072
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655568

SequenceSite368
type: SequenceSite
position status: EQUAL
sequence position: 1

Q25790
type: Protein
entity reference: Q25790
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Tubulin alpha-3C/D chain
name: TUBA3C unfolded
name: unfolded alpha tubulin 2.2
name: TBA3C_HUMAN
xref: UnificationXref4069
feature: FragmentFeature748
cellular location: GO:0005829
comment: Reactome DB_ID: 3655565
display name: TUBA3C

SequenceSite367
type: SequenceSite
position status: EQUAL
sequence position: 1382

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IFP3
data source: Provenance1
name: unfolded alpha tubulin 6
name: TUBA1C unfolded
xref: UnificationXref4066
feature: FragmentFeature746
cellular location: GO:0005829
comment: Reactome DB_ID: 3655562
display name: Q8IFP3

SequenceSite366
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6ZLZ9
data source: Provenance1
name: unfolded alpha tubulin 6
name: TUBA1C unfolded
xref: UnificationXref4067
feature: FragmentFeature747
cellular location: GO:0005829
comment: Reactome DB_ID: 3655563
display name: Q6ZLZ9

SequenceSite365
type: SequenceSite
position status: EQUAL
sequence position: 1382

Homologues of TUBA1C unfolded
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4068
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655564

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q25790
data source: Provenance1
name: unfolded alpha tubulin 6
name: TUBA1C unfolded
xref: UnificationXref4065
feature: FragmentFeature745
cellular location: GO:0005829
comment: Reactome DB_ID: 3655561
display name: Q25790

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IFP3
data source: Provenance1
name: TUBA1B unfolded
name: unfolded alpha K tubulin -1
name: Unfolded tubulin K-alpha-1
xref: UnificationXref4062
feature: FragmentFeature743
cellular location: GO:0005829
comment: Reactome DB_ID: 3655558
display name: Q8IFP3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6ZLZ9
data source: Provenance1
name: TUBA1B unfolded
name: unfolded alpha K tubulin -1
name: Unfolded tubulin K-alpha-1
xref: UnificationXref4063
feature: FragmentFeature744
cellular location: GO:0005829
comment: Reactome DB_ID: 3655559
display name: Q6ZLZ9

SequenceSite369
type: SequenceSite
position status: EQUAL
sequence position: 1382

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q25790
data source: Provenance1
name: TUBA1B unfolded
name: unfolded alpha K tubulin -1
name: Unfolded tubulin K-alpha-1
xref: UnificationXref4061
feature: FragmentFeature742
cellular location: GO:0005829
comment: Reactome DB_ID: 3655557
display name: Q25790

http://identifiers.org/pubmed/21799019
type: PublicationXref
id: 21799019
author: Wu, Lawren C
db: Pubmed
title: Immunoglobulin E receptor signaling and asthma
source: J. Biol. Chem. 286:32891-7
year: 2011

http://identifiers.org/pubmed/11459976
type: PublicationXref
id: 11459976
author: Bell, SP
author: Klemm, RD
db: Pubmed
title: ATP bound to the origin recognition complex is important for preRC formation.
source: Proc Natl Acad Sci U S A 98:8361-7
year: 2001

http://identifiers.org/pubmed/22394562
type: PublicationXref
id: 22394562
author: Tanaka, Yasuo
author: Chen, Zhijian J
db: Pubmed
title: STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
source: Sci Signal 5:ra20
year: 2012

UniProt:Q8IBR6
type: ProteinReference
xref: UnificationXref4051
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C6KST5
data source: Provenance1
name: T-complex protein 1 subunit zeta (TCP-1-zeta)
name: C6KST5
xref: UnificationXref4088
feature: FragmentFeature756
cellular location: GO:0005829
comment: Reactome DB_ID: 3655545
display name: CCT6A

SequenceSite333
type: SequenceSite
position status: EQUAL
sequence position: 1382

Q8I5C4
type: Protein
entity reference: Q8I5C4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: T-complex protein 1 subunit gamma (TCP-1-gamma)
xref: UnificationXref4090
feature: FragmentFeature757
cellular location: GO:0005829
comment: Reactome DB_ID: 3655537
display name: CCT3

SequenceSite332
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8II43
data source: Provenance1
name: T-complex protein 1 subunit alpha (TCP-1-alpha)
name: Q8II43
xref: UnificationXref4092
feature: FragmentFeature758
cellular location: GO:0005829
comment: Reactome DB_ID: 3655517
display name: TCP1

SequenceSite335
type: SequenceSite
position status: EQUAL
sequence position: 1382

Homologues of EIF5A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4125
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655168

SequenceSite334
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite331
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite330
type: SequenceSite
position status: EQUAL
sequence position: 1

Q6ZLZ9
type: Protein
entity reference: Q6ZLZ9
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Tubulin alpha-3C/D chain
name: TUBA3C unfolded
name: unfolded alpha tubulin 2.2
name: TBA3C_HUMAN
xref: UnificationXref4071
feature: FragmentFeature750
cellular location: GO:0005829
comment: Reactome DB_ID: 3655567
display name: TUBA3C

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O96220
data source: Provenance1
name: O96220
name: T-complex protein 1 subunit theta (TCP-1-theta)
xref: UnificationXref4078
feature: FragmentFeature751
cellular location: GO:0005829
comment: Reactome DB_ID: 3655541
display name: CCT8

O97282
type: Protein
entity reference: UniProt:O97282
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: T-complex protein 1 subunit epsilon (TCP-1-epsilon)
xref: UnificationXref4080
feature: FragmentFeature752
cellular location: GO:0005829
comment: Reactome DB_ID: 3655529
display name: CCT5

SequenceSite337
type: SequenceSite
position status: EQUAL
sequence position: 1382

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O77323
data source: Provenance1
name: O77323
name: T-complex protein 1 subunit eta (TCP-1-eta)
xref: UnificationXref4082
feature: FragmentFeature753
cellular location: GO:0005829
comment: Reactome DB_ID: 3655533
display name: CCT7

SequenceSite336
type: SequenceSite
position status: EQUAL
sequence position: 1

C0H5I7
type: Protein
entity reference: C0H5I7
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: T-complex protein 1 subunit delta (TCP-1-delta)
xref: UnificationXref4084
feature: FragmentFeature754
cellular location: GO:0005829
comment: Reactome DB_ID: 3655525
display name: CCT4

SequenceSite339
type: SequenceSite
position status: EQUAL
sequence position: 1382

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O97247
data source: Provenance1
name: T-complex protein 1 subunit beta (TCP-1-beta)
name: O97247
xref: UnificationXref4086
feature: FragmentFeature755
cellular location: GO:0005829
comment: Reactome DB_ID: 3655521
display name: CCT2

SequenceSite338
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q8IBQ5
type: ProteinReference
xref: UnificationXref1025
organism: BioSource1

UniProt:Q8IBQ6
type: ProteinReference
xref: UnificationXref1110
organism: BioSource1

SequenceSite346
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite345
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite344
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite343
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite342
type: SequenceSite
position status: EQUAL
sequence position: 1

DNA Replication Pre-Initiation
type: Pathway
data source: Provenance1
pathway component: REACT 92770.9
evidence: Evidence611
xref: UnificationXref5029
xref: UnificationXref5028
pathway order: PathwayStep564
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite341
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite340
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite349
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite348
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/10583946
type: PublicationXref
id: 10583946
author: Wood, RD
author: Lindahl, T
db: Pubmed
title: Quality control by DNA repair
source: Science 286:1897-905
year: 1999

SequenceSite347
type: SequenceSite
position status: EQUAL
sequence position: 1382

http://identifiers.org/pubmed/12121577
type: PublicationXref
id: 12121577
author: Safrany, ST
author: Leslie, NR
author: McLennan, AG
db: Pubmed
title: Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases
source: BMC Biochem 3:20
year: 2002

UniProt:Q7YUD6
type: ProteinReference
xref: UnificationXref562
organism: BioSource1

http://identifiers.org/pubmed/17050193
type: PublicationXref
id: 17050193
author: Tridandapani, S
author: Butchar, JP
author: Joshi, T
db: Pubmed
title: Fcgamma receptor signaling in phagocytes
source: Int J Hematol 84:210-6
year: 2006

http://identifiers.org/pubmed/11741323
type: PublicationXref
id: 11741323
author: Minoshima, S
author: Shimizu, A
author: Kawasaki, K
author: Shimizu, N
author: Asakawa, S
author: Sasaki, T
author: Shiohama, A
author: Shintani, A
db: Pubmed
title: Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants
source: Biochem Biophys Res Commun 289:1218-24
year: 2001

http://identifiers.org/pubmed/15207811
type: PublicationXref
id: 15207811
author: Li, H
author: Fredriksson, L
author: Eriksson, U
db: Pubmed
title: The PDGF family: four gene products form five dimeric isoforms
source: Cytokine Growth Factor Rev 15:197-204
year: 2004

http://identifiers.org/pubmed/9556621
type: PublicationXref
id: 9556621
author: Riese DJ, 2nd
author: Stern, DF
author: Komurasaki, T
author: Plowman, GD
db: Pubmed
title: Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2
source: J Biol Chem 273:11288-94
year: 1998

http://identifiers.org/pubmed/11459989
type: PublicationXref
id: 11459989
author: Paulusma, C
author: Wyman, C
author: Kanaar, R
author: Ristic, D
db: Pubmed
title: The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA.
source: Proc Natl Acad Sci U S A 98:8454-60
year: 2001

http://identifiers.org/pubmed/9792662
type: PublicationXref
id: 9792662
author: Morgunov, I
author: Srere, PA
db: Pubmed
title: Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate
source: J Biol Chem 273:29540-29544
year: 1998

SequenceSite398
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite399
type: SequenceSite
position status: EQUAL
sequence position: 679

SequenceSite396
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite397
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite394
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite395
type: SequenceSite
position status: EQUAL
sequence position: 1382

Phospholipase C-mediated cascade
type: Pathway
data source: Provenance1
pathway component: REACT 112227.8
evidence: Evidence22
xref: UnificationXref216
xref: UnificationXref215
pathway order: PathwayStep12
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite383
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite384
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite385
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite386
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite387
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite388
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite389
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite391
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite390
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite393
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite392
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9417066
type: PublicationXref
id: 9417066
author: Larsson, PK
author: Kennedy, BP
author: Claesson, HE
db: Pubmed
title: Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity
source: J Biol Chem 273:207-14
year: 1998

UniProt:Q8IBU1
type: ProteinReference
xref: UnificationXref686
organism: BioSource1

SequenceSite374
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite375
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite372
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite373
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite378
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite379
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite376
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite377
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite382
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite381
type: SequenceSite
position status: EQUAL
sequence position: 1382

SequenceSite380
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q07412
type: ProteinReference
xref: UnificationXref1278
organism: BioSource1

http://identifiers.org/pubmed/15153429
type: PublicationXref
id: 15153429
author: Berezin, V
author: Bock, E
author: Kiryushko, D
db: Pubmed
title: Regulators of neurite outgrowth: role of cell adhesion molecules
source: Ann N Y Acad Sci 1014:140-54
year: 2004

PLC beta mediated events
type: Pathway
data source: Provenance1
pathway component: REACT 112832.8
evidence: Evidence836
xref: UnificationXref6043
xref: UnificationXref6042
pathway order: PathwayStep809
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/9265629
type: PublicationXref
id: 9265629
author: Triana-Alonso, FJ
author: Petrushenko, ZM
author: Ovcharenko, GV
author: El'skaya, AV
author: Palchevskii, SS
author: Nierhaus, KH
db: Pubmed
title: Three tRNA binding sites in rabbit liver ribosomes and role of the intrinsic ATPase in 80S ribosomes from higher eukaryotes
source: Biochemistry 36:10492-7
year: 1997

Acetaminophen glutathion
type: SmallMoleculeReference
name: AA-Gsh
name: AA-Glutathion
name: acetaminophen glutathione conjugate
name: Glutathione-S-acetaminophen conjugate
name: 3-(Glutathion-S-yl)acetaminophen
name: acetaminophen glutathione conjugate [ChEBI:32639]
xref: UnificationXref3563

http://identifiers.org/pubmed/11124962
type: PublicationXref
id: 11124962
author: Wilson, GM
author: Brewer, G
author: Chuang, Ky
author: Sutphen, K
db: Pubmed
title: Folding of A+U-rich RNA elements modulates AUF1 binding. Potential roles in regulation of mRNA turnover
source: J Biol Chem 276:8695-704
year: 2001

Vitamin C (ascorbate) metabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction190
pathway component: BiochemicalReaction189
evidence: Evidence353
xref: UnificationXref3030
xref: UnificationXref3029
xref: RelationshipXref360
pathway order: PathwayStep346
pathway order: PathwayStep347
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/20861159
type: PublicationXref
id: 20861159
author: Nilius, B
author: Colsoul, B
author: Gees, M
db: Pubmed
title: The role of transient receptor potential cation channels in Ca2+ signaling
source: Cold Spring Harb Perspect Biol 2:a003962
year: 2010

Fatty Acyl-CoA Biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction86
pathway component: REACT 112844.8
evidence: Evidence199
xref: RelationshipXref165
xref: UnificationXref1736
xref: UnificationXref1735
pathway order: PathwayStep184
pathway order: PathwayStep193
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

2,6-diaminohexanoic acid
type: SmallMoleculeReference
name: Lysine acid
name: L-Lysine [ChEBI:18019]
name: L-Lysine
xref: UnificationXref5468

UniProt:Q8IBY4
type: ProteinReference
xref: UnificationXref1138
organism: BioSource1

http://identifiers.org/pubmed/9265649
type: PublicationXref
id: 9265649
author: Feierbach, B
author: Stearns, T
author: Rommelaere, H
author: Tian, G
author: Cowan, NJ
author: Lewis, SA
author: Ampe, C
db: Pubmed
title: Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors
source: J Cell Biol 138:821-32
year: 1997

http://identifiers.org/pubmed/17555404
type: PublicationXref
id: 17555404
author: Alp, NJ
author: Schmidt, TS
db: Pubmed
title: Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
source: Clin Sci (Lond) 113:47-63
year: 2007

NADP+
type: SmallMoleculeReference
name: TPN
name: NADP+ [ChEBI:18009]
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref351

Urea synthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction215
pathway component: BiochemicalReaction216
pathway component: BiochemicalReaction217
pathway component: BiochemicalReaction214
evidence: Evidence395
xref: RelationshipXref418
xref: UnificationXref3358
xref: UnificationXref3357
pathway order: PathwayStep387
pathway order: PathwayStep389
pathway order: PathwayStep386
pathway order: PathwayStep388
display name: Urea cycle
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/9878398
type: PublicationXref
id: 9878398
author: Mirande, M
author: Siatecka, M
author: Robinson, JC
author: Berthonneau, E
author: Quevillon, S
db: Pubmed
title: Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein
source: J Mol Biol 285:183-95
year: 1999

http://identifiers.org/pubmed/15893380
type: PublicationXref
id: 15893380
author: Jackowski, S
author: Zhang, YM
author: Rock, CO
author: Leonardi, R
db: Pubmed
title: Coenzyme A: back in action
source: Prog Lipid Res 44:125-53
year: 2005

UnificationXref1903
type: UnificationXref
id: 3656567
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656567

UnificationXref1902
type: UnificationXref
id: 3656566
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656566

UnificationXref1905
type: UnificationXref
id: 3656573
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656573

UnificationXref1904
type: UnificationXref
id: 3656568
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656568

UnificationXref1901
type: UnificationXref
id: O96266
db: UniProt

UnificationXref1900
type: UnificationXref
id: REACT_122663
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122663.1

http://identifiers.org/pubmed/17635959
type: PublicationXref
id: 17635959
author: Blodgett, DM
author: Karim, P
author: Carruthers, A
author: De Zutter, JK
author: Levine, KB
db: Pubmed
title: Structural basis of GLUT1 inhibition by cytoplasmic ATP
source: J Gen Physiol 130:157-68
year: 2007

http://identifiers.org/pubmed/9083049
type: PublicationXref
id: 9083049
author: Lee, PT
author: Shepherd, JA
author: Tzagoloff, A
author: Myles, DC
author: Clarke, CF
author: Shtanko, A
author: Barkovich, RJ
db: Pubmed
title: Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis
source: J Biol Chem 272:9182-8
year: 1997

UnificationXref1907
type: UnificationXref
id: CHEBI:17984
db: ChEBI

UnificationXref1906
type: UnificationXref
id: REACT_155691
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155691.3

UnificationXref1909
type: UnificationXref
id: REACT_118995
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118995.1

UnificationXref1908
type: UnificationXref
id: 1500578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500578

Maintenance of Telomeres
type: Pathway
data source: Provenance1
pathway component: REACT 77975.9
evidence: Evidence623
xref: RelationshipXref556
xref: UnificationXref5063
xref: UnificationXref5062
pathway order: PathwayStep606
display name: Telomere Maintenance
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref299
type: UnificationXref
id: 3657538
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657538

UnificationXref297
type: UnificationXref
id: 3657537
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657537

UnificationXref298
type: UnificationXref
id: REACT_157426
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157426.3

UnificationXref295
type: UnificationXref
id: 3657536
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657536

UnificationXref296
type: UnificationXref
id: REACT_154638
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154638.3

UnificationXref293
type: UnificationXref
id: 3656948
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656948

UnificationXref294
type: UnificationXref
id: REACT_157685
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157685.3

http://identifiers.org/pubmed/10380910
type: PublicationXref
id: 10380910
author: Karimi, K
author: Lennartz, MR
author: Gemmill, TR
db: Pubmed
title: Protein kinase C and a calcium-independent phospholipase are required for IgG-mediated phagocytosis by Mono-Mac-6 cells
source: J Leukoc Biol 65:854-62
year: 1999

UnificationXref291
type: UnificationXref
id: 3656511
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656511

UnificationXref292
type: UnificationXref
id: 3656512
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656512

UnificationXref290
type: UnificationXref
id: D5L5S3
db: UniProt

http://identifiers.org/pubmed/21682741
type: PublicationXref
id: 21682741
author: Minnicozzi, M
author: Fenton, MJ
author: Sawyer, RT
db: Pubmed
title: Innate immunity in allergic disease
source: Immunol Rev 242:106-27
year: 2011

http://identifiers.org/pubmed/15520807
type: PublicationXref
id: 15520807
author: Wellbrock, C
author: Karasarides, M
author: Marais, R
db: Pubmed
title: The RAF proteins take centre stage
source: Nat Rev Mol Cell Biol 5:875-85
year: 2004

UnificationXref1930
type: UnificationXref
id: 1500603
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500603

UnificationXref1921
type: UnificationXref
id: 3657506
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657506

UnificationXref1920
type: UnificationXref
id: REACT_155338
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155338.3

UnificationXref1923
type: UnificationXref
id: CHEBI:17553
db: ChEBI

UnificationXref1922
type: UnificationXref
id: REACT_130519
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130519.5

UnificationXref1925
type: UnificationXref
id: REACT_20211
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20211.2

Activation of Genes by ATF4
type: Pathway
data source: Provenance1
pathway component: Expression of Asparagine Synthetase
evidence: Evidence557
xref: UnificationXref4482
xref: UnificationXref4481
pathway order: PathwayStep543
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1924
type: UnificationXref
id: 428686
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428686

UnificationXref1927
type: UnificationXref
id: 110614
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110614

UnificationXref1926
type: UnificationXref
id: CHEBI:17677
db: ChEBI

UnificationXref1929
type: UnificationXref
id: CHEBI:16732
db: ChEBI

UnificationXref1928
type: UnificationXref
id: REACT_5335
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5335.1

http://identifiers.org/pubmed/22101253
type: PublicationXref
id: 22101253
author: Rouault, Tracey A
author: Kovtunovych, Gennadiy
author: Crooks, Daniel R
author: Shi, Yanbo
author: Ghosh, Manik
db: Pubmed
title: Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis
source: Biochim. Biophys. Acta 1823:484-92
year: 2012

UnificationXref1912
type: UnificationXref
id: CHEBI:17389
db: ChEBI

UnificationXref1911
type: UnificationXref
id: REACT_142379
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142379.5

UnificationXref1910
type: UnificationXref
id: 3656586
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656586

UnificationXref1916
type: UnificationXref
id: REACT_158816
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158816.3

UnificationXref1915
type: UnificationXref
id: 3656581
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656581

UnificationXref1914
type: UnificationXref
id: REACT_124200
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124200.1

UnificationXref1913
type: UnificationXref
id: 1498728
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1498728

UnificationXref1919
type: UnificationXref
id: 3656570
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656570

UnificationXref1918
type: UnificationXref
id: REACT_155865
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155865.3

UnificationXref1917
type: UnificationXref
id: 3656571
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656571

http://identifiers.org/pubmed/1377674
type: PublicationXref
id: 1377674
author: Nairn, AC
author: Cohn, JA
author: Bertuzzi, G
author: Greengard, P
author: Picciotto, MR
db: Pubmed
title: Phosphorylation of the cystic fibrosis transmembrane conductance regulator
source: J Biol Chem 267:12742-52
year: 1992

http://identifiers.org/pubmed/11752427
type: PublicationXref
id: 11752427
author: McCarthy, DB
author: Stoops, JK
author: O'Connor, CM
author: Reed, LJ
author: Zhou, ZH
db: Pubmed
title: The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes.
source: Proc Natl Acad Sci U S A 98:14802-7
year: 2001

http://identifiers.org/pubmed/16854592
type: PublicationXref
id: 16854592
author: Wu, Y
author: Feder, JN
author: Cheng, D
author: Mintier, GA
author: Tamura, JK
author: Chu, CH
author: Harpel, MR
author: Locke, GA
author: An, Y
author: Cook, JW
author: Chen, L
db: Pubmed
title: Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes
source: Protein Expr Purif 51:11-21
year: 2007

UnificationXref263
type: UnificationXref
id: 3656497
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656497

UnificationXref1950
type: UnificationXref
id: CHEBI:17361
db: ChEBI

UnificationXref262
type: UnificationXref
id: A7XLD6
db: UniProt

NADPH regeneration
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction102
pathway component: BiochemicalReaction103
evidence: Evidence219
xref: UnificationXref1851
xref: RelationshipXref186
xref: UnificationXref1852
pathway order: PathwayStep213
pathway order: PathwayStep212
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref265
type: UnificationXref
id: 3656498
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656498

UnificationXref1952
type: UnificationXref
id: REACT_4841
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4841.2

UnificationXref264
type: UnificationXref
id: D5L5S8
db: UniProt

UnificationXref1951
type: UnificationXref
id: 109395
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109395

UnificationXref261
type: UnificationXref
id: 3656496
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656496

UnificationXref260
type: UnificationXref
id: D0QEX1
db: UniProt

UnificationXref267
type: UnificationXref
id: 3656499
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656499

http://identifiers.org/pubmed/9593753
type: PublicationXref
id: 9593753
author: Jackowski, S
author: Lykidis, A
author: Murti, KG
db: Pubmed
title: Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase
source: J Biol Chem 273:14022-9
year: 1998

UnificationXref266
type: UnificationXref
id: A7XLD3
db: UniProt

UnificationXref269
type: UnificationXref
id: 3656500
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656500

UnificationXref268
type: UnificationXref
id: D0QF15
db: UniProt

UnificationXref1946
type: UnificationXref
id: 3656650
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656650

UnificationXref1947
type: UnificationXref
id: REACT_136981
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136981.5

UnificationXref1948
type: UnificationXref
id: 1500581
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500581

UnificationXref1949
type: UnificationXref
id: REACT_124951
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124951.1

UnificationXref1942
type: UnificationXref
id: 3656645
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656645

UnificationXref1943
type: UnificationXref
id: 3656646
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656646

UnificationXref1944
type: UnificationXref
id: 3656647
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656647

UnificationXref1945
type: UnificationXref
id: 3656648
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656648

UnificationXref254
type: UnificationXref
id: D0QEX4
db: UniProt

UnificationXref1941
type: UnificationXref
id: 3656644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656644

UnificationXref253
type: UnificationXref
id: 3656492
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656492

UnificationXref1940
type: UnificationXref
id: REACT_14559
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14559.2

UnificationXref252
type: UnificationXref
id: D0QF22
db: UniProt

UnificationXref251
type: UnificationXref
id: 3656491
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656491

UnificationXref250
type: UnificationXref
id: D0QEV4
db: UniProt

UnificationXref259
type: UnificationXref
id: 3656495
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656495

UnificationXref258
type: UnificationXref
id: D0QEU3
db: UniProt

UnificationXref257
type: UnificationXref
id: 3656494
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656494

UnificationXref256
type: UnificationXref
id: D0QEU8
db: UniProt

UnificationXref255
type: UnificationXref
id: 3656493
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656493

UnificationXref1939
type: UnificationXref
id: 217314
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=217314

UnificationXref1937
type: UnificationXref
id: 426755
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426755

UnificationXref1938
type: UnificationXref
id: REACT_120138
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120138.1

UnificationXref1935
type: UnificationXref
id: 3656643
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656643

UnificationXref1936
type: UnificationXref
id: REACT_131995
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131995.5

UnificationXref1933
type: UnificationXref
id: 3656640
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656640

UnificationXref1934
type: UnificationXref
id: 3656641
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656641

UnificationXref1931
type: UnificationXref
id: REACT_124825
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124825.1

UnificationXref1932
type: UnificationXref
id: Q8IDM2
db: UniProt

UnificationXref281
type: UnificationXref
id: 3656506
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656506

UnificationXref280
type: UnificationXref
id: D0QF40
db: UniProt

UnificationXref283
type: UnificationXref
id: 3656507
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656507

UnificationXref1970
type: UnificationXref
id: REACT_2572
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2572.1

UnificationXref282
type: UnificationXref
id: D0QEZ6
db: UniProt

UnificationXref285
type: UnificationXref
id: 3656508
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656508

UnificationXref1972
type: UnificationXref
id: 1500661
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500661

UnificationXref284
type: UnificationXref
id: D0QEX7
db: UniProt

UnificationXref1971
type: UnificationXref
id: CHEBI:45360
db: ChEBI

UnificationXref287
type: UnificationXref
id: 3656509
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656509

UnificationXref1974
type: UnificationXref
id: Q8I2N0
db: UniProt

UnificationXref286
type: UnificationXref
id: Q9U0N4
db: UniProt

UnificationXref1973
type: UnificationXref
id: REACT_122049
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122049.1

UnificationXref289
type: UnificationXref
id: 3656510
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656510

UnificationXref288
type: UnificationXref
id: D0QEZ3
db: UniProt

di-mu-sulfido-diiron(2+) [ChEBI:33737]
type: SmallMoleculeReference
name: [Fe2S2](2+)
name: [2Fe-2S](2+)
name: di-mu-sulfido-diiron(2+)
name: [Fe2(mu-S)2](2+)
xref: UnificationXref3599

[Fe2S2](+)
type: SmallMoleculeReference
name: di-mu-sulfido-diiron(1+)
name: [2Fe-2S](1+)
name: di-mu-sulfido-diiron(1+) [ChEBI:33738]
name: [Fe2(mu-S)2](+)
xref: UnificationXref3605

UnificationXref1964
type: UnificationXref
id: REACT_140975
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140975.5

UnificationXref1965
type: UnificationXref
id: 1500644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500644

UnificationXref1966
type: UnificationXref
id: REACT_123472
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123472.1

UnificationXref1967
type: UnificationXref
id: 1524083
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524083

UnificationXref1968
type: UnificationXref
id: REACT_124336
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124336.1

UnificationXref1969
type: UnificationXref
id: 29376
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29376

UnificationXref272
type: UnificationXref
id: D0QF19
db: UniProt

UnificationXref271
type: UnificationXref
id: 3656501
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656501

UnificationXref270
type: UnificationXref
id: D0QF07
db: UniProt

UnificationXref276
type: UnificationXref
id: D5L5S7
db: UniProt

UnificationXref1963
type: UnificationXref
id: 3656607
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656607

UnificationXref275
type: UnificationXref
id: 3656503
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656503

UnificationXref1962
type: UnificationXref
id: 3656605
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656605

UnificationXref274
type: UnificationXref
id: D0QF23
db: UniProt

UnificationXref1961
type: UnificationXref
id: 3656604
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656604

UnificationXref273
type: UnificationXref
id: 3656502
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656502

UnificationXref1960
type: UnificationXref
id: 3656603
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656603

UnificationXref279
type: UnificationXref
id: 3656505
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656505

UnificationXref278
type: UnificationXref
id: D0QEV0
db: UniProt

di-retinoid-pyridinium-ethanolamine
type: SmallMoleculeReference
name: di-retinoid-pyridinium-ethanolamine [ChEBI:71980]
name: A2E
xref: UnificationXref332

UnificationXref277
type: UnificationXref
id: 3656504
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656504

Mucopolysaccharidoses
type: Pathway
data source: Provenance1
pathway component: REACT 157787.3
pathway component: MPS IIID - Sanfilippo syndrome D
pathway component: REACT 159304.3
pathway component: REACT 154165.3
pathway component: REACT 145050.5
pathway component: REACT 155907.3
pathway component: REACT 159876.3
pathway component: MPS IIIC - Sanfilippo syndrome C
pathway component: REACT 146371.5
pathway component: REACT 156349.3
pathway component: REACT 131004.5
evidence: Evidence41
xref: UnificationXref324
xref: UnificationXref323
pathway order: PathwayStep40
pathway order: PathwayStep39
pathway order: PathwayStep31
pathway order: PathwayStep36
pathway order: PathwayStep33
pathway order: PathwayStep30
pathway order: PathwayStep34
pathway order: PathwayStep38
pathway order: PathwayStep32
pathway order: PathwayStep37
pathway order: PathwayStep35
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1955
type: UnificationXref
id: 1500595
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500595

UnificationXref1956
type: UnificationXref
id: REACT_122641
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122641.1

UnificationXref1953
type: UnificationXref
id: C6KTB9
db: UniProt

UnificationXref1954
type: UnificationXref
id: 3656599
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656599

UnificationXref1959
type: UnificationXref
id: 3656600
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656600

UnificationXref1957
type: UnificationXref
id: 1500591
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500591

UnificationXref1958
type: UnificationXref
id: REACT_123902
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123902.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:B9ZSI8
data source: Provenance1
name: DOLK_HUMAN
name: Dolichol kinase
name: B9ZSI8
xref: UnificationXref4230
feature: FragmentFeature780
cellular location: GO:0005789
comment: Reactome DB_ID: 3655866
display name: DOLK

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IDS3
data source: Provenance1
name: phosphatidylinositol glycan, class B
name: Q8IDS3
name: PIG-B
xref: UnificationXref4216
feature: FragmentFeature779
cellular location: GO:0005789
comment: Reactome DB_ID: 3654549
display name: PIGB

Q6PV86
type: Protein
entity reference: Q6PV86
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: phosphatidylinositol glycan, class B
name: PIG-B
xref: UnificationXref4214
feature: FragmentFeature778
cellular location: GO:0005789
comment: Reactome DB_ID: 3654547
display name: PIGB

Homologues of PIGB
type: Protein
data source: Provenance1
member physical entity: Q6PV86
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4217
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3654550

UnificationXref1565
type: UnificationXref
id: REACT_151822
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151822.1

UnificationXref1564
type: UnificationXref
id: 1629740
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629740

UnificationXref1567
type: UnificationXref
id: REACT_152401
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152401.1

UnificationXref1566
type: UnificationXref
id: 1629732
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629732

UnificationXref1561
type: UnificationXref
id: REACT_152078
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152078.1

SequenceSite2410
type: SequenceSite
position status: EQUAL
sequence position: 170

UnificationXref1560
type: UnificationXref
id: 1629759
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629759

UnificationXref1563
type: UnificationXref
id: REACT_156205
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156205.3

UnificationXref1562
type: UnificationXref
id: 3656837
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656837

SequenceSite2414
type: SequenceSite
position status: EQUAL
sequence position: 521

http://identifiers.org/pubmed/15157936
type: PublicationXref
id: 15157936
author: Bertinato, J
author: L'Abbé, MR
db: Pubmed
title: Maintaining copper homeostasis: regulation of copper-trafficking proteins in response to copper deficiency or overload
source: J Nutr Biochem 15:316-22
year: 2004

SequenceSite2413
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/18614531
type: PublicationXref
id: 18614531
author: Duncan, RE
author: Ahmadian, M
author: Sarkadi-Nagy, E
author: Sul, HS
author: Jaworski, K
db: Pubmed
title: Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA)
source: J Biol Chem 283:25428-36
year: 2008

SequenceSite2412
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite2411
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2418
type: SequenceSite
position status: EQUAL
sequence position: 170

UnificationXref1557
type: UnificationXref
id: REACT_150662
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150662.1

SequenceSite2417
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref1558
type: UnificationXref
id: 3656892
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656892

SequenceSite2416
type: SequenceSite
position status: EQUAL
sequence position: 170

UnificationXref1559
type: UnificationXref
id: REACT_153761
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153761.3

SequenceSite2415
type: SequenceSite
position status: EQUAL
sequence position: 2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8IJF3
data source: Provenance1
name: Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) 1
name: Q8IJF3
xref: UnificationXref4239
feature: FragmentFeature781
cellular location: GO:0005829
comment: Reactome DB_ID: 3655900
display name: GFPT1

Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) 2
type: Protein
entity reference: Q8IJF3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: GFPT2(2-682)
name: Q8IJF3
xref: UnificationXref4240
feature: FragmentFeature782
cellular location: GO:0005829
comment: Reactome DB_ID: 3655901
display name: GFPT2

SequenceSite2419
type: SequenceSite
position status: EQUAL
sequence position: 1

GFPT1/2
type: Protein
data source: Provenance1
member physical entity: Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) 2
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4241
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655902

PMM1/2
type: Protein
data source: Provenance1
member physical entity: Q8IJM5
xref: UnificationXref4274
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655874

Q8IJM5
type: Protein
entity reference: Q8IJM5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PMM1_HUMAN
name: Phosphomannomutase 1
xref: UnificationXref4272
feature: FragmentFeature785
cellular location: GO:0005829
comment: Reactome DB_ID: 3655872
display name: PMM1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8II63
data source: Provenance1
name: Phosphoacetylglucosamine mutase
name: Q8II63
name: AGM1_HUMAN
xref: UnificationXref4251
feature: FragmentFeature783
cellular location: GO:0005829
comment: Reactome DB_ID: 3655854
display name: PGM3

Q8IDQ3
type: Protein
entity reference: Q8IDQ3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: UDP-N-acetylhexosamine pyrophosphorylase
name: UAP1_HUMAN
xref: UnificationXref4258
feature: FragmentFeature784
cellular location: GO:0005829
comment: Reactome DB_ID: 3655880
display name: UAP1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8ILP1
data source: Provenance1
name: Q8ILP1
name: Mannose-1-phosphate guanyltransferase beta
name: GMPPB_HUMAN
xref: UnificationXref4281
feature: FragmentFeature787
cellular location: GO:0005829
comment: Reactome DB_ID: 3655894
display name: GMPPB

UnificationXref1570
type: UnificationXref
id: 3657528
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657528

Q8IJM5
type: Protein
entity reference: Q8IJM5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PMM2_HUMAN
name: Phosphomannomutase 2
xref: UnificationXref4273
feature: FragmentFeature786
cellular location: GO:0005829
comment: Reactome DB_ID: 3655873
display name: PMM2

Uroporphyrinogen I
type: SmallMoleculeReference
name: Uroporphyrinogen I [ChEBI:9904]
xref: UnificationXref3455

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O97321
data source: Provenance1
name: O97321
name: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
name: GPT_HUMAN
xref: UnificationXref4292
feature: FragmentFeature788
cellular location: GO:0005789
comment: Reactome DB_ID: 3655860
display name: DPAGT1

UnificationXref1578
type: UnificationXref
id: 1629756
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629756

UnificationXref1577
type: UnificationXref
id: CHEBI:4170
db: ChEBI

http://identifiers.org/pubmed/19675644
type: PublicationXref
id: 19675644
author: Ribbe, MW
author: Mendel, RR
author: Schwarz, G
db: Pubmed
title: Molybdenum cofactors, enzymes and pathways
source: Nature 460:839-47
year: 2009

UnificationXref1576
type: UnificationXref
id: REACT_153756
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153756.3

http://identifiers.org/pubmed/19675643
type: PublicationXref
id: 19675643
author: Lill, R
db: Pubmed
title: Function and biogenesis of iron-sulphur proteins
source: Nature 460:831-8
year: 2009

UnificationXref1575
type: UnificationXref
id: 3656839
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656839

UnificationXref1574
type: UnificationXref
id: REACT_150507
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150507.1

UnificationXref1573
type: UnificationXref
id: 1629739
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629739

UnificationXref1572
type: UnificationXref
id: CHEBI:17816
db: ChEBI

UnificationXref1571
type: UnificationXref
id: REACT_158294
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158294.3

SequenceSite2401
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2400
type: SequenceSite
position status: EQUAL
sequence position: 456

SequenceSite2403
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2402
type: SequenceSite
position status: EQUAL
sequence position: 622

SequenceSite2405
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/16533814
type: PublicationXref
id: 16533814
author: Kang, KR
author: McPhie, P
author: Bell, JK
author: Park, MH
author: Wolff, EC
author: Kim, YS
db: Pubmed
title: Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected].
source: J Biol Chem 281:13217-25
year: 2006

SequenceSite2404
type: SequenceSite
position status: EQUAL
sequence position: 622

SequenceSite2407
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref1568
type: UnificationXref
id: 3656864
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656864

SequenceSite2406
type: SequenceSite
position status: EQUAL
sequence position: 622

UnificationXref1569
type: UnificationXref
id: REACT_138744
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138744.5

SequenceSite2409
type: SequenceSite
position status: EQUAL
sequence position: 2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O96196
data source: Provenance1
name: O96196
name: UDP-N-acetylglucosamine transferase subunit ALG14 homolog
name: ALG14_HUMAN
xref: UnificationXref4299
feature: FragmentFeature789
cellular location: GO:0005789
comment: Reactome DB_ID: 3655888
display name: ALG14

SequenceSite2408
type: SequenceSite
position status: EQUAL
sequence position: 170

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H5J6
data source: Provenance1
name: S24A_HUMAN
name: Protein transport protein Sec24A
name: C0H5J6
xref: UnificationXref4305
feature: FragmentFeature790
cellular location: GO:0005829
comment: Reactome DB_ID: 3655098
display name: SEC24A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H5J6
data source: Provenance1
name: S24B_HUMAN
name: Protein transport protein Sec24B
name: C0H5J6
xref: UnificationXref4306
feature: FragmentFeature791
cellular location: GO:0005829
comment: Reactome DB_ID: 3655099
display name: SEC24B

Homologues of SEC24C
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4311
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655102

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8T622
data source: Provenance1
name: S24C_HUMAN
name: Q8T622
name: Protein transport protein Sec24C
xref: UnificationXref4308
feature: FragmentFeature792
cellular location: GO:0005829
comment: Reactome DB_ID: 3655100
display name: SEC24C

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H489
data source: Provenance1
name: S24C_HUMAN
name: C0H489
name: Protein transport protein Sec24C
xref: UnificationXref4310
feature: FragmentFeature793
cellular location: GO:0005829
comment: Reactome DB_ID: 3655101
display name: SEC24C

Homologues of SEC24D
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4314
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655105

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8T622
data source: Provenance1
name: Protein transport protein Sec24D
name: Q8T622
name: S24D_HUMAN
xref: UnificationXref4312
feature: FragmentFeature794
cellular location: GO:0005829
comment: Reactome DB_ID: 3655103
display name: SEC24D

Dhp-EIF5A2(2-153)
type: Protein
entity reference: UniProt:Q8MX76
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: EIF5A2(Dhp)
name: Eukaryotic tranlation initiation factor 5A2
xref: UnificationXref4137
feature: FragmentFeature765
feature: ModificationFeature42
cellular location: GO:0005829
comment: Reactome DB_ID: 3655162
display name: Q8MX76

Homologues of Dhp-EIF5A2(2-153)
type: Protein
data source: Provenance1
member physical entity: Dhp-EIF5A2(2-153)
xref: UnificationXref4139
cellular location: GO:0005829
comment: Reactome DB_ID: 3655164
comment: Converted from EntitySet in Reactome

http://identifiers.org/pubmed/19244110
type: PublicationXref
id: 19244110
author: Vikis, HG
author: You, M
author: Lu, Y
author: Liu, Y
author: James, MA
db: Pubmed
title: RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway
source: Cancer Res 69:2108-16
year: 2009

Dhp-EIF5A
type: Protein
entity reference: Q8I603
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: EIF5A(Dhp)
name: Eukaryotic translation initiation factor 5A-1
name: IF5A1_HUMAN
xref: UnificationXref4135
feature: ModificationFeature43
feature: FragmentFeature764
cellular location: GO:0005829
comment: Reactome DB_ID: 3655160
display name: Q8I603

Dhp-EIF5A
type: Protein
entity reference: UniProt:Q8MX76
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: EIF5A(Dhp)
name: Eukaryotic translation initiation factor 5A-1
name: IF5A1_HUMAN
xref: UnificationXref4134
feature: ModificationFeature42
feature: FragmentFeature763
cellular location: GO:0005829
comment: Reactome DB_ID: 3655157
display name: Q8MX76

Homologues of Dhp-EIF5A
type: Protein
data source: Provenance1
member physical entity: Dhp-EIF5A
xref: UnificationXref4136
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655161

EIF5A2(2-153)
type: Protein
entity reference: Q8I603
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8I603
name: Eukaryotic tranlation initiation factor 5A2
xref: UnificationXref4127
feature: FragmentFeature762
cellular location: GO:0005829
comment: Reactome DB_ID: 3655170
display name: EIF5A2

UnificationXref1541
type: UnificationXref
id: REACT_152024
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152024.1

UnificationXref1540
type: UnificationXref
id: 1629755
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629755

UnificationXref1543
type: UnificationXref
id: 3656834
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656834

UnificationXref1542
type: UnificationXref
id: 3656833
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656833

UnificationXref1545
type: UnificationXref
id: 3656888
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656888

UnificationXref1544
type: UnificationXref
id: 3656835
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656835

UnificationXref1535
type: UnificationXref
id: REACT_158709
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158709.3

UnificationXref1536
type: UnificationXref
id: 3657526
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657526

UnificationXref1537
type: UnificationXref
id: REACT_155343
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155343.3

UnificationXref1538
type: UnificationXref
id: 994141
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=994141

UnificationXref1539
type: UnificationXref
id: REACT_25926
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25926.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q9GSW0
data source: Provenance1
name: Deoxyhypusine synthase monomer
name: Q9GSW0
xref: UnificationXref4144
feature: FragmentFeature768
cellular location: GO:0005829
comment: Reactome DB_ID: 3655178
display name: DHPS

Same Catalyst Activity
type: RelationshipTypeVocabulary

Homologues of Hypu-EIF5A2(2-153)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4156
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655188

Homologues of DHPS
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4145
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655179

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8ILW8
data source: Provenance1
name: Deoxyhypusine synthase monomer
name: Q8ILW8
xref: UnificationXref4142
feature: FragmentFeature767
cellular location: GO:0005829
comment: Reactome DB_ID: 3655176
display name: DHPS

Dhp-EIF5A2(2-153)
type: Protein
entity reference: Q8I603
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: EIF5A2(Dhp)
name: Eukaryotic tranlation initiation factor 5A2
xref: UnificationXref4138
feature: ModificationFeature43
feature: FragmentFeature766
cellular location: GO:0005829
comment: Reactome DB_ID: 3655163
display name: Q8I603

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I603
data source: Provenance1
name: Q8I603
name: Eukaryotic translation initiation factor 5A
name: Hypu-EIF5A
name: IF5A1_HUMAN
xref: UnificationXref4158
feature: FragmentFeature772
feature: ModificationFeature45
cellular location: GO:0005829
comment: Reactome DB_ID: 3655190
display name: Hyp50

PI Metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 28201.10
evidence: Evidence259
xref: UnificationXref2121
xref: RelationshipXref240
xref: UnificationXref2122
pathway order: PathwayStep253
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I603
data source: Provenance1
name: Hypu-EIF5A2
name: EIF5A2(Hyp50)
name: Hypu-EIF5A2(2-153)
xref: UnificationXref4155
feature: FragmentFeature770
feature: ModificationFeature45
cellular location: GO:0005829
comment: Reactome DB_ID: 3655187
display name: Q8I603

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8MX76
data source: Provenance1
name: Hypu-EIF5A2
name: EIF5A2(Hyp50)
name: Hypu-EIF5A2(2-153)
xref: UnificationXref4154
feature: ModificationFeature44
feature: FragmentFeature769
cellular location: GO:0005829
comment: Reactome DB_ID: 3655185
display name: Q8MX76

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8MX76
data source: Provenance1
name: Q8MX76
name: Eukaryotic translation initiation factor 5A
name: Hypu-EIF5A
name: IF5A1_HUMAN
xref: UnificationXref4157
feature: ModificationFeature44
feature: FragmentFeature771
cellular location: GO:0005829
comment: Reactome DB_ID: 3655189
display name: Hyp50

Homologues of Hypu-EIF5A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4159
cellular location: GO:0005829
comment: Reactome DB_ID: 3655191
comment: Converted from EntitySet in Reactome

UnificationXref1552
type: UnificationXref
id: 3656862
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656862

UnificationXref1551
type: UnificationXref
id: REACT_150686
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150686.1

http://identifiers.org/pubmed/22100452
type: PublicationXref
id: 22100452
author: Weis, David D
author: Williams, Todd D
author: Creamer, Trevor P
author: Dunker, A Keith
author: Rumi-Masante, Julie
author: Dunlap, Tori B
author: Rusinga, Farai I
author: Lester, Terrence E
db: Pubmed
title: Structural basis for activation of calcineurin by calmodulin
source: J. Mol. Biol. 415:307-17
year: 2012

UnificationXref1550
type: UnificationXref
id: 1629738
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629738

UnificationXref1556
type: UnificationXref
id: 1629765
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629765

UnificationXref1555
type: UnificationXref
id: REACT_151222
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151222.1

UnificationXref1554
type: UnificationXref
id: 1629770
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629770

UnificationXref1553
type: UnificationXref
id: REACT_157566
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157566.3

UnificationXref1548
type: UnificationXref
id: 1629736
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629736

http://identifiers.org/pubmed/16856888
type: PublicationXref
id: 16856888
author: Tomer, A
author: Deutsch, VR
db: Pubmed
title: Megakaryocyte development and platelet production
source: Br J Haematol 134:453-66
year: 2006

UnificationXref1549
type: UnificationXref
id: REACT_151437
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151437.1

UnificationXref1546
type: UnificationXref
id: REACT_153448
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153448.3

UnificationXref1547
type: UnificationXref
id: CHEBI:62926
db: ChEBI

Homologues of PIGW
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: C6KSZ4
xref: UnificationXref4191
cellular location: GO:0005789
comment: Reactome DB_ID: 3654541
comment: Converted from EntitySet in Reactome

C6KSZ4
type: Protein
entity reference: C6KSZ4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PIG-W
name: phosphatidylinositol glycan, class W
xref: UnificationXref4188
feature: FragmentFeature775
cellular location: GO:0005789
comment: Reactome DB_ID: 3654538
display name: PIGW

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6A0I5
data source: Provenance1
name: PIG-W
name: phosphatidylinositol glycan, class W
name: Q6A0I5
xref: UnificationXref4190
feature: FragmentFeature776
cellular location: GO:0005789
comment: Reactome DB_ID: 3654540
display name: PIGW

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I4V9
data source: Provenance1
name: GPI mannosyltransferase II
name: Q8I4V9
name: phosphatidylinositol glycan, class V
name: PIG-V
xref: UnificationXref4207
feature: FragmentFeature777
cellular location: GO:0005789
comment: Reactome DB_ID: 3654562
display name: PIGV

Q8I701
type: Protein
entity reference: UniProt:Q8I701
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Deoxyhypusine hydroxylase apoenzyme
name: DOHH apoenzyme
xref: UnificationXref4162
feature: FragmentFeature773
cellular location: GO:0005829
comment: Reactome DB_ID: 3655196
display name: DOHH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C6KT83
data source: Provenance1
name: PIG-L
name: phosphatidylinositol glycan, class L
name: C6KT83
name: N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
xref: UnificationXref4179
feature: FragmentFeature774
cellular location: GO:0005789
comment: Reactome DB_ID: 3654556
display name: PIGL

UnificationXref1520
type: UnificationXref
id: REACT_151792
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151792.1

UnificationXref1521
type: UnificationXref
id: 3656868
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656868

UnificationXref1522
type: UnificationXref
id: REACT_154704
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154704.3

UnificationXref1523
type: UnificationXref
id: CHEBI:62985
db: ChEBI

Homologues of SEC31A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4366
cellular location: GO:0012507
comment: Reactome DB_ID: 3655126
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I1S0
data source: Provenance1
name: SAR1B GTP-binding protein
name: SARA2
name: Q8I1S0
xref: UnificationXref4362
feature: FragmentFeature815
cellular location: GO:0012507
comment: Reactome DB_ID: 3655141
display name: SAR1B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U8B7
data source: Provenance1
name: SAR1B GTP-binding protein
name: SARA2
name: Q9U8B7
xref: UnificationXref4361
feature: FragmentFeature814
cellular location: GO:0012507
comment: Reactome DB_ID: 3655140
display name: SAR1B

Homologues of SAR1B
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4363
cellular location: GO:0012507
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655142

http://identifiers.org/pubmed/17380317
type: PublicationXref
id: 17380317
author: Hussain, K
author: Richardson, CC
author: Christie, MR
author: Jones, PM
author: Löbner, K
author: Clark, A
author: Persaud, S
author: Boehm, A
db: Pubmed
title: Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development
source: Diabetologia 50:1000-5
year: 2007

SC13_HUMAN
type: Protein
entity reference: Q8I5B3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8I5B3
name: SEC13-related protein
name: SEC13L1
xref: UnificationXref4367
feature: FragmentFeature818
cellular location: GO:0012507
comment: Reactome DB_ID: 3655127
display name: SEC13

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O96221
data source: Provenance1
name: Protein transport protein Sec31A
name: SC31A_HUMAN
name: O96221
xref: UnificationXref4365
feature: FragmentFeature817
cellular location: GO:0012507
comment: Reactome DB_ID: 3655125
display name: SEC31A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q689C9
data source: Provenance1
name: Protein transport protein Sec31A
name: Q689C9
name: SC31A_HUMAN
xref: UnificationXref4364
feature: FragmentFeature816
cellular location: GO:0012507
comment: Reactome DB_ID: 3655124
display name: SEC31A

UnificationXref1518
type: UnificationXref
id: CHEBI:30164
db: ChEBI

UnificationXref1517
type: UnificationXref
id: REACT_150776
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150776.1

UnificationXref1519
type: UnificationXref
id: 2023940
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023940

SC13_HUMAN
type: Protein
entity reference: Q8I5B3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8I5B3
name: SEC13-related protein
name: SEC13L1
xref: UnificationXref4355
feature: FragmentFeature813
cellular location: GO:0005789
comment: Reactome DB_ID: 3655121
display name: SEC13

UnificationXref1514
type: UnificationXref
id: REACT_152740
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152740.3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O96221
data source: Provenance1
name: Protein transport protein Sec31A
name: SC31A_HUMAN
name: O96221
xref: UnificationXref4353
feature: FragmentFeature812
cellular location: GO:0005789
comment: Reactome DB_ID: 3655116
display name: SEC31A

UnificationXref1513
type: UnificationXref
id: 3656896
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656896

http://identifiers.org/pubmed/19010255
type: PublicationXref
id: 19010255
author: Neu-Yilik, G
author: Kulozik, AE
db: Pubmed
title: NMD: multitasking between mRNA surveillance and modulation of gene expression
source: Adv Genet 62:185-243
year: 2008

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q689C9
data source: Provenance1
name: Protein transport protein Sec31A
name: Q689C9
name: SC31A_HUMAN
xref: UnificationXref4352
feature: FragmentFeature811
cellular location: GO:0005789
comment: Reactome DB_ID: 3655114
display name: SEC31A

UnificationXref1516
type: UnificationXref
id: 2023929
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023929

UnificationXref1515
type: UnificationXref
id: CHEBI:17401
db: ChEBI

UnificationXref1533
type: UnificationXref
id: REACT_151603
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151603.1

UnificationXref1534
type: UnificationXref
id: 3656832
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656832

http://identifiers.org/pubmed/592399
type: PublicationXref
id: 592399
author: Schreier, MH
author: Trachsel, H
author: Staehelin, T
author: Erni, B
db: Pubmed
title: Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors.
source: J Mol Biol 116:755-67
year: 1978

UnificationXref1531
type: UnificationXref
id: CHEBI:62923
db: ChEBI

UnificationXref1532
type: UnificationXref
id: 2023931
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023931

http://identifiers.org/pubmed/592398
type: PublicationXref
id: 592398
author: Schreier, MH
author: Staehelin, T
author: Erni, B
db: Pubmed
title: Initiation of mammalian protein synthesis. I. Purification and characterization of seven initiation factors.
source: J Mol Biol 116:727-53
year: 1978

UnificationXref1530
type: UnificationXref
id: REACT_151781
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151781.1

Homologues of SEC24D
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4376
cellular location: GO:0012507
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655136

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H489
data source: Provenance1
name: S24C_HUMAN
name: C0H489
name: Protein transport protein Sec24C
xref: UnificationXref4372
feature: FragmentFeature822
cellular location: GO:0012507
comment: Reactome DB_ID: 3655132
display name: SEC24C

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H489
data source: Provenance1
name: Protein transport protein Sec24D
name: C0H489
name: S24D_HUMAN
xref: UnificationXref4375
feature: FragmentFeature824
cellular location: GO:0012507
comment: Reactome DB_ID: 3655135
display name: SEC24D

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8T622
data source: Provenance1
name: Protein transport protein Sec24D
name: Q8T622
name: S24D_HUMAN
xref: UnificationXref4374
feature: FragmentFeature823
cellular location: GO:0012507
comment: Reactome DB_ID: 3655134
display name: SEC24D

Homologues of SLC25A6
type: Protein
data source: Provenance1
member physical entity: adenine nucleotide translocator 3
xref: UnificationXref4398
cellular location: GO:0005758
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3656375

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8IB60
data source: Provenance1
name: Protein transport protein Sec23A
name: Q8IB60
name: S23A_HUMAN
xref: UnificationXref4378
feature: FragmentFeature825
cellular location: GO:0012507
comment: Reactome DB_ID: 3655138
display name: SEC23A

UnificationXref1529
type: UnificationXref
id: 2023932
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023932

UnificationXref1528
type: UnificationXref
id: CHEBI:62919
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H5J6
data source: Provenance1
name: S24B_HUMAN
name: Protein transport protein Sec24B
name: C0H5J6
xref: UnificationXref4370
feature: FragmentFeature820
cellular location: GO:0012507
comment: Reactome DB_ID: 3655130
display name: SEC24B

UnificationXref1527
type: UnificationXref
id: REACT_154873
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154873.3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H5J6
data source: Provenance1
name: S24A_HUMAN
name: Protein transport protein Sec24A
name: C0H5J6
xref: UnificationXref4369
feature: FragmentFeature819
cellular location: GO:0012507
comment: Reactome DB_ID: 3655129
display name: SEC24A

UnificationXref1526
type: UnificationXref
id: 3656890
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656890

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8T622
data source: Provenance1
name: S24C_HUMAN
name: Q8T622
name: Protein transport protein Sec24C
xref: UnificationXref4371
feature: FragmentFeature821
cellular location: GO:0012507
comment: Reactome DB_ID: 3655131
display name: SEC24C

UnificationXref1525
type: UnificationXref
id: REACT_151655
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151655.1

Homologues of SEC24C
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4373
cellular location: GO:0012507
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655133

UnificationXref1524
type: UnificationXref
id: 2023941
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023941

http://identifiers.org/pubmed/12040175
type: PublicationXref
id: 12040175
author: Iyengar, R
author: Ram, PT
author: Neves, SR
db: Pubmed
title: G protein pathways
source: Science 296:1636-9
year: 2002

UnificationXref1500
type: UnificationXref
id: 3656860
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656860

UnificationXref1501
type: UnificationXref
id: REACT_157300
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157300.3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H489
data source: Provenance1
name: Protein transport protein Sec24D
name: C0H489
name: S24D_HUMAN
xref: UnificationXref4313
feature: FragmentFeature795
cellular location: GO:0005829
comment: Reactome DB_ID: 3655104
display name: SEC24D

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8IB60
data source: Provenance1
name: Protein transport protein Sec23A
name: Q8IB60
name: S23A_HUMAN
xref: UnificationXref4317
feature: FragmentFeature796
cellular location: GO:0005829
comment: Reactome DB_ID: 3655107
display name: SEC23A

Homologues of SEC24D
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4332
cellular location: GO:0005789
comment: Reactome DB_ID: 3655086
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H489
data source: Provenance1
name: S24C_HUMAN
name: C0H489
name: Protein transport protein Sec24C
xref: UnificationXref4328
feature: FragmentFeature802
cellular location: GO:0005789
comment: Reactome DB_ID: 3655082
display name: SEC24C

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8T622
data source: Provenance1
name: S24C_HUMAN
name: Q8T622
name: Protein transport protein Sec24C
xref: UnificationXref4327
feature: FragmentFeature801
cellular location: GO:0005789
comment: Reactome DB_ID: 3655080
display name: SEC24C

Homologues of SEC24C
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4329
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655083

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H5J6
data source: Provenance1
name: S24B_HUMAN
name: Protein transport protein Sec24B
name: C0H5J6
xref: UnificationXref4326
feature: FragmentFeature800
cellular location: GO:0005789
comment: Reactome DB_ID: 3655076
display name: SEC24B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H5J6
data source: Provenance1
name: S24A_HUMAN
name: Protein transport protein Sec24A
name: C0H5J6
xref: UnificationXref4325
feature: FragmentFeature799
cellular location: GO:0005789
comment: Reactome DB_ID: 3655075
display name: SEC24A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I1S0
data source: Provenance1
name: SAR1B GTP-binding protein
name: SARA2
name: Q8I1S0
xref: UnificationXref4322
feature: FragmentFeature798
cellular location: GO:0005789
comment: Reactome DB_ID: 3655069
display name: SAR1B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U8B7
data source: Provenance1
name: SAR1B GTP-binding protein
name: SARA2
name: Q9U8B7
xref: UnificationXref4320
feature: FragmentFeature797
cellular location: GO:0005789
comment: Reactome DB_ID: 3655067
display name: SAR1B

Homologues of SAR1B
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4323
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655070

SequenceSite2421
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2420
type: SequenceSite
position status: EQUAL
sequence position: 521

UnificationXref1511
type: UnificationXref
id: 2023948
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023948

UnificationXref1512
type: UnificationXref
id: REACT_151435
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151435.1

G alpha (s) signalling events
type: Pathway
data source: Provenance1
pathway component: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
pathway component: cAMP degradation by Phosphodiesterases
evidence: Evidence831
xref: UnificationXref6033
xref: UnificationXref6032
pathway order: PathwayStep803
pathway order: PathwayStep804
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1510
type: UnificationXref
id: CHEBI:62931
db: ChEBI

UniProt:C3S7P8
type: ProteinReference
xref: UnificationXref2727
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8T622
data source: Provenance1
name: Protein transport protein Sec24D
name: Q8T622
name: S24D_HUMAN
xref: UnificationXref4330
feature: FragmentFeature803
cellular location: GO:0005789
comment: Reactome DB_ID: 3655084
display name: SEC24D

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O96221
data source: Provenance1
name: Protein transport protein Sec31A
name: SC31A_HUMAN
name: O96221
xref: UnificationXref4348
feature: FragmentFeature809
cellular location: GO:0005829
comment: Reactome DB_ID: 3655147
display name: SEC31A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q689C9
data source: Provenance1
name: Protein transport protein Sec31A
name: Q689C9
name: SC31A_HUMAN
xref: UnificationXref4346
feature: FragmentFeature808
cellular location: GO:0005829
comment: Reactome DB_ID: 3655146
display name: SEC31A

Homologues of SEC31A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4354
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655117

SC13_HUMAN
type: Protein
entity reference: Q8I5B3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8I5B3
name: SEC13-related protein
xref: UnificationXref4351
feature: FragmentFeature810
cellular location: GO:0005829
comment: Reactome DB_ID: 3655149
display name: SEC13

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q9U8B7
data source: Provenance1
name: SAR1B GTP-binding protein
name: SARA2
name: Q9U8B7
xref: UnificationXref4339
feature: FragmentFeature806
cellular location: GO:0005829
comment: Reactome DB_ID: 3655094
display name: SAR1B

Homologues of SAR1B
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4341
cellular location: GO:0005829
comment: Reactome DB_ID: 3655096
comment: Converted from EntitySet in Reactome

Homologues of SEC31A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4349
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655148

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I1S0
data source: Provenance1
name: SAR1B GTP-binding protein
name: SARA2
name: Q8I1S0
xref: UnificationXref4340
feature: FragmentFeature807
cellular location: GO:0005829
comment: Reactome DB_ID: 3655095
display name: SAR1B

SequenceSite2426
type: SequenceSite
position status: EQUAL
sequence position: 149

UnificationXref1505
type: UnificationXref
id: 3656828
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656828

SequenceSite2427
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1504
type: UnificationXref
id: REACT_151186
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151186.1

SequenceSite2428
type: SequenceSite
position status: EQUAL
sequence position: 512

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8IB60
data source: Provenance1
name: Protein transport protein Sec23A
name: Q8IB60
name: S23A_HUMAN
xref: UnificationXref4334
feature: FragmentFeature805
cellular location: GO:0005789
comment: Reactome DB_ID: 3655091
display name: SEC23A

UnificationXref1503
type: UnificationXref
id: 2023922
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2023922

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C0H489
data source: Provenance1
name: Protein transport protein Sec24D
name: C0H489
name: S24D_HUMAN
xref: UnificationXref4331
feature: FragmentFeature804
cellular location: GO:0005789
comment: Reactome DB_ID: 3655085
display name: SEC24D

UnificationXref1502
type: UnificationXref
id: CHEBI:62928
db: ChEBI

SequenceSite2422
type: SequenceSite
position status: EQUAL
sequence position: 524

UnificationXref1509
type: UnificationXref
id: REACT_156785
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156785.3

SequenceSite2423
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref1508
type: UnificationXref
id: 3656857
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656857

SequenceSite2424
type: SequenceSite
position status: EQUAL
sequence position: 149

UnificationXref1507
type: UnificationXref
id: 3656830
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656830

SequenceSite2425
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref1506
type: UnificationXref
id: 3656829
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656829

SequenceSite219
type: SequenceSite
position status: EQUAL
sequence position: 1480

http://identifiers.org/pubmed/8083230
type: PublicationXref
id: 8083230
author: Strifler, BA
author: Manetta, JV
author: Sharp, JD
author: Kovacevic, S
author: Pickard, RT
author: Miller, JR
author: Chiou, XG
author: Varshavsky, AD
author: Brems, DN
author: Roberts, EF
db: Pubmed
title: Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2
source: J Biol Chem 269:23250-4
year: 1994

http://identifiers.org/pubmed/20192804
type: PublicationXref
id: 20192804
author: Batista, FD
author: Harwood, NE
db: Pubmed
title: Early events in B cell activation
source: Annu Rev Immunol 28:185-210
year: 2010

SequenceSite216
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite215
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite218
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite217
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite212
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite211
type: SequenceSite
position status: EQUAL
sequence position: 1480

'ATP [cytosol]' is required for 'Ribosomal scanning '
type: Control
data source: Provenance1
xref: UnificationXref3786
controlled: BiochemicalReaction247
control type: ACTIVATION
controller: SmallMolecule16

SequenceSite214
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite213
type: SequenceSite
position status: EQUAL
sequence position: 1480

http://identifiers.org/pubmed/7000367
type: PublicationXref
id: 7000367
author: Kozak, M
db: Pubmed
title: Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes.
source: Cell 22:7-8
year: 1981

http://identifiers.org/pubmed/11912132
type: PublicationXref
id: 11912132
author: Lam, W
author: Jiang, Z
author: Cheng, YC
author: Dutschman, GE
author: Liou, JY
db: Pubmed
title: Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.
source: Cancer Res 62:1624-31
year: 2002

SequenceSite210
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/2332429
type: PublicationXref
id: 2332429
author: Vance, JE
db: Pubmed
title: Phospholipid synthesis in a membrane fraction associated with mitochondria
source: J Biol Chem 265:7248-56
year: 1990

http://identifiers.org/pubmed/16682955
type: PublicationXref
id: 16682955
author: Hays, S
author: Westbrook, L
author: Qu, Z
author: Kern, FG
author: Thottassery, JV
author: Rentz, SS
author: Manuvakhova, M
db: Pubmed
title: Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells
source: Oncogene 25:6003-14
year: 2006

'Pb2+ [mitochondrial matrix]' negatively regulates 'FECH binds Fe2+ to PRIN9 to form heme'
type: Control
data source: Provenance1
xref: UnificationXref3499
controlled: BiochemicalReaction226
control type: INHIBITION
controller: SmallMolecule455

'heme [mitochondrial matrix]' negatively regulates 'ALAS condenses SUCC-CoA and Gly to form dALA'
type: Control
data source: Provenance1
xref: UnificationXref3401
controlled: BiochemicalReaction219
control type: INHIBITION
controller: SmallMolecule438

'GTP [cytosol]' is required for 'Met-tRNAi binds to eIF2:GTP to form the ternary complex'
type: Control
data source: Provenance1
xref: UnificationXref3774
controlled: BiochemicalReaction245
control type: ACTIVATION
controller: SmallMolecule268

'GSH [cytosol]' negatively regulates 'gamma-glutamylcysteine combines with glycine to form glutathione'
type: Control
data source: Provenance1
xref: UnificationXref3546
controlled: BiochemicalReaction230
control type: INHIBITION
controller: SmallMolecule238

SequenceSite229
type: SequenceSite
position status: EQUAL
sequence position: 1480

'Mg2+ [cytosol]' is required for 'ITPA hydrolyses XTP to XMP'
type: Control
data source: Provenance1
xref: UnificationXref3000
controlled: BiochemicalReaction188
control type: ACTIVATION
controller: SmallMolecule84

SequenceSite228
type: SequenceSite
position status: EQUAL
sequence position: 1

'Mg2+ [cytosol]' is required for 'ITPA hydrolyses dITP to dIMP'
type: Control
data source: Provenance1
xref: UnificationXref2994
controlled: BiochemicalReaction187
control type: ACTIVATION
controller: SmallMolecule84

SequenceSite227
type: SequenceSite
position status: EQUAL
sequence position: 1480

'NAcGlu [mitochondrial matrix]' positively regulates '2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]'
type: Control
data source: Provenance1
xref: UnificationXref3317
controlled: BiochemicalReaction214
control type: ACTIVATION
controller: SmallMolecule424

SequenceSite226
type: SequenceSite
position status: EQUAL
sequence position: 1

'Mg2+ [cytosol]' is required for 'A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN)'
type: Control
data source: Provenance1
xref: UnificationXref3144
controlled: BiochemicalReaction201
control type: ACTIVATION
controller: SmallMolecule84

SequenceSite225
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite224
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite223
type: SequenceSite
position status: EQUAL
sequence position: 1480

'Mg2+ [cytosol]' is required for 'ITPA hydrolyses ITP to IMP'
type: Control
data source: Provenance1
xref: UnificationXref2985
controlled: BiochemicalReaction186
control type: ACTIVATION
controller: SmallMolecule84

SequenceSite222
type: SequenceSite
position status: EQUAL
sequence position: 1

'dATP [cytosol]' negatively regulates 'NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O'
type: Control
data source: Provenance1
xref: UnificationXref2898
controlled: BiochemicalReaction179
control type: INHIBITION
controller: SmallMolecule344

http://identifiers.org/pubmed/10412983
type: PublicationXref
id: 10412983
author: Slot, JW
author: Klumperman, J
author: Martínez-Menárguez, JA
author: Geuze, HJ
db: Pubmed
title: Vesicular tubular clusters between the ER and Golgi mediate concentration of soluble secretory proteins by exclusion from COPI-coated vesicles
source: Cell 98:81-90
year: 1999

SequenceSite221
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite220
type: SequenceSite
position status: EQUAL
sequence position: 1

adenine nucleotide translocator 3
type: Protein
entity reference: Q25692
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenine nucleotide translocator 3
name: ADP/ATP translocase 3 monomer
name: SLC25A6
name: Q25692
name: ADP/ATP translocase 3
name: ADP,ATP carrier protein, liver isoform T2
xref: UnificationXref4396
feature: FragmentFeature827
cellular location: GO:0005758
comment: Reactome DB_ID: 3656373
display name: ANT 3

SequenceSite238
type: SequenceSite
position status: EQUAL
sequence position: 1

adenine nucleotide translocator 3
type: Protein
entity reference: Q8IJ34
data source: Provenance1
name: Q8IJ34
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenine nucleotide translocator 3
name: ADP/ATP translocase 3 monomer
name: SLC25A6
name: ADP/ATP translocase 3
name: ADP,ATP carrier protein, liver isoform T2
xref: UnificationXref4397
feature: FragmentFeature828
cellular location: GO:0005758
comment: Reactome DB_ID: 3656374
display name: ANT 3

SequenceSite237
type: SequenceSite
position status: EQUAL
sequence position: 1480

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8ID24
data source: Provenance1
name: TIM9_HUMAN
name: Q8ID24
name: TIMM9 (disulfide-bonded)
name: 4xHC-TIMM9(2-89)
name: Mitochondrial import inner membrane translocase subunit Tim9
xref: UnificationXref4401
feature: FragmentFeature829
feature: ModificationFeature46
feature: ModificationFeature48
feature: ModificationFeature49
feature: ModificationFeature47
cellular location: GO:0005743
comment: Reactome DB_ID: 3656370
display name: TIMM9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8I5W2
data source: Provenance1
name: Q8I5W2
name: TIMM10 (disulfide-bonded)
name: TIM10_HUMAN
name: Mitochondrial import inner membrane translocase subunit Tim10
name: 4xHC-TIMM10
xref: UnificationXref4403
feature: FragmentFeature830
feature: ModificationFeature53
feature: ModificationFeature52
feature: ModificationFeature51
feature: ModificationFeature50
cellular location: GO:0005743
comment: Reactome DB_ID: 3656362
display name: TIMM10

SequenceSite239
type: SequenceSite
position status: EQUAL
sequence position: 1480

adenine nucleotide translocator 3
type: Protein
entity reference: Q26006
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenine nucleotide translocator 3
name: ADP/ATP translocase 3 monomer
name: SLC25A6
name: Q26006
name: ADP/ATP translocase 3
name: ADP,ATP carrier protein, liver isoform T2
xref: UnificationXref4395
feature: FragmentFeature826
cellular location: GO:0005758
comment: Reactome DB_ID: 3656372
display name: ANT 3

O77344
type: Protein
entity reference: O77344
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Glycogen synthase kinase-3 alpha
name: KG3A_HUMAN
name: GSK3A(1-483)
xref: UnificationXref4436
feature: FragmentFeature835
cellular location: GO:0005829
comment: Reactome DB_ID: 3654938
display name: GSK3A

SequenceSite230
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite232
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite231
type: SequenceSite
position status: EQUAL
sequence position: 1480

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P12794
data source: Provenance1
name: 78 kDa glucose-regulated protein
name: GRP78
name: HSPA5
name: P12794
xref: UnificationXref4412
feature: FragmentFeature831
cellular location: GO:0005789
comment: Reactome DB_ID: 3655276
display name: BiP

SequenceSite234
type: SequenceSite
position status: EQUAL
sequence position: 1

Endoplasmin
type: Protein
entity reference: Q8I0V4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ENPL_HUMAN
name: HSP90B1
xref: UnificationXref4416
feature: FragmentFeature832
cellular location: GO:0005788
comment: Reactome DB_ID: 3656738
display name: Q8I0V4

SequenceSite233
type: SequenceSite
position status: EQUAL
sequence position: 1480

Q8IE72
type: Protein
entity reference: Q8IE72
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDX11_HUMAN
name: Probable ATP-dependent RNA helicase DDX11
xref: UnificationXref4426
feature: FragmentFeature833
cellular location: GO:0005654
comment: Reactome DB_ID: 3656717
display name: DDX11

SequenceSite236
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: C6KTC7
data source: Provenance1
name: C6KTC7
name: DNAJB11
name: ERdj3
xref: UnificationXref4430
feature: FragmentFeature834
cellular location: GO:0005788
comment: Reactome DB_ID: 3656706
display name: HEDJ

SequenceSite235
type: SequenceSite
position status: EQUAL
sequence position: 1480

UniProt:Q8IB37
type: ProteinReference
xref: UnificationXref2067
organism: BioSource1

UniProt:Q8IAR6
type: ProteinReference
xref: UnificationXref883
organism: BioSource1

UniProt:Q8IAR3
type: ProteinReference
xref: UnificationXref879
organism: BioSource1

Linoleic acid (LA) metabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction134
pathway component: BiochemicalReaction132
pathway component: BiochemicalReaction133
evidence: Evidence268
xref: RelationshipXref243
xref: UnificationXref2183
xref: UnificationXref2182
pathway order: PathwayStep260
pathway order: PathwayStep262
pathway order: PathwayStep261
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite249
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite248
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite243
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite242
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite241
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite240
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite247
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite246
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite245
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite244
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/18395510
type: PublicationXref
id: 18395510
author: Bigotti, MG
author: Clarke, AR
db: Pubmed
title: Chaperonins: The hunt for the Group II mechanism
source: Arch Biochem Biophys 474:331-9
year: 2008

UniProt:Q8IAQ8
type: ProteinReference
xref: UnificationXref38
organism: BioSource1

DNA strand elongation
type: Pathway
data source: Provenance1
pathway component: REACT 31129.10
pathway component: REACT 107877.9
pathway component: REACT 89865.9
evidence: Evidence606
xref: UnificationXref5018
xref: RelationshipXref551
xref: UnificationXref5019
pathway order: PathwayStep581
pathway order: PathwayStep589
pathway order: PathwayStep586
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite250
type: SequenceSite
position status: EQUAL
sequence position: 1

late endosome membrane
type: CellularLocationVocabulary
xref: UnificationXref94

endosome lumen
type: CellularLocationVocabulary
xref: UnificationXref680

http://identifiers.org/pubmed/8163536
type: PublicationXref
id: 8163536
author: Sidorenko, SP
author: Chandran, KA
author: Clark, EA
author: Disteche, CM
author: Edelhoff, S
author: Law, CL
author: Weiss, A
author: Chan, AC
author: Draves, KE
db: Pubmed
title: Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex
source: J Biol Chem 269:12310-9
year: 1994

http://identifiers.org/pubmed/18321209
type: PublicationXref
id: 18321209
author: Jansen, T
author: Daiber, A
author: Schulz, E
author: Wenzel, P
author: Münzel, T
db: Pubmed
title: Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension
source: Antioxid Redox Signal 10:1115-26
year: 2008

UniProt:Q8IAM8
type: ProteinReference
xref: UnificationXref5917
organism: BioSource1

http://identifiers.org/pubmed/6568109
type: PublicationXref
id: 6568109
author: Carvalho, JF
author: Carvalho, MD
author: Merrick, WC
db: Pubmed
title: Biological characterization of various forms of elongation factor 1 from rabbit reticulocytes
source: Arch Biochem Biophys 234:603-11
year: 1984

UnificationXref1579
type: UnificationXref
id: REACT_152414
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152414.1

http://identifiers.org/pubmed/12488490
type: PublicationXref
id: 12488490
author: García-García, E
author: Rosales, C
db: Pubmed
title: Signal transduction during Fc receptor-mediated phagocytosis
source: J Leukoc Biol 72:1092-108
year: 2002

http://identifiers.org/pubmed/12522561
type: PublicationXref
id: 12522561
author: Islam, Rafiqul
author: Storch, Stephan
author: Wittenstein, Birgit
author: Braulke, T
author: Sly, WS
author: Ullrich, K
db: Pubmed
title: Mutational analysis in longest known survivor of mucopolysaccharidosis type VII
source: Hum. Genet. 112:190-4
year: 2003

UnificationXref1584
type: UnificationXref
id: 3656852
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656852

UnificationXref1585
type: UnificationXref
id: CHEBI:15846
db: ChEBI

UnificationXref1582
type: UnificationXref
id: REACT_150575
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150575.1

UnificationXref1583
type: UnificationXref
id: Q8I3Y8
db: UniProt

UnificationXref1588
type: UnificationXref
id: 3656853
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656853

MPS IIIC - Sanfilippo syndrome C
type: Pathway
data source: Provenance1
pathway component: REACT 153330.3
evidence: Evidence34
xref: UnificationXref310
xref: UnificationXref309
pathway order: PathwayStep29
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1589
type: UnificationXref
id: 3656855
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656855

UnificationXref1586
type: UnificationXref
id: 29360
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29360

UnificationXref1587
type: UnificationXref
id: REACT_5381
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5381.1

half cystine
type: SequenceModificationVocabulary
xref: UnificationXref2871

UnificationXref1580
type: UnificationXref
id: CHEBI:18169
db: ChEBI

UnificationXref1581
type: UnificationXref
id: 1629731
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629731

http://identifiers.org/pubmed/8722040
type: PublicationXref
id: 8722040
author: Pape, T
author: Fricke, R
author: Wintermeyer, W
author: Rodnina, MV
db: Pubmed
title: Elongation factor Tu, a GTPase triggered by codon recognition on the ribosome: mechanism and GTP consumption
source: Biochem Cell Biol 73:1221-7
year: 1995

SequenceSite202
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite203
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite200
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite201
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite206
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite207
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite204
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite205
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite208
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite209
type: SequenceSite
position status: EQUAL
sequence position: 1480

UnificationXref1593
type: UnificationXref
id: 3657527
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657527

UnificationXref1594
type: UnificationXref
id: REACT_154677
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154677.3

UnificationXref1595
type: UnificationXref
id: CHEBI:16113
db: ChEBI

UnificationXref1596
type: UnificationXref
id: 171149
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=171149

UnificationXref1597
type: UnificationXref
id: REACT_7360
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7360.2

UnificationXref1598
type: UnificationXref
id: CHEBI:16110
db: ChEBI

UnificationXref1599
type: UnificationXref
id: 194276
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194276

Abacavir transport and metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 143619.5
evidence: Evidence426
xref: UnificationXref3626
xref: UnificationXref3625
pathway order: PathwayStep420
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1590
type: UnificationXref
id: REACT_154728
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154728.3

UnificationXref1591
type: UnificationXref
id: 3657529
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657529

UnificationXref1592
type: UnificationXref
id: REACT_153494
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153494.3

http://identifiers.org/pubmed/11780755
type: PublicationXref
id: 11780755
author: Thorens, B
db: Pubmed
title: GLUT2 in pancreatic and extra-pancreatic gluco-detection (review)
source: Mol Membr Biol 18:265-73
year: 2001

http://identifiers.org/pubmed/11780753
type: PublicationXref
id: 11780753
author: Joost, HG
author: Thorens, B
db: Pubmed
title: The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review)
source: Mol Membr Biol 18:247-56
year: 2001

UniProt:Q8IAW2
type: ProteinReference
xref: UnificationXref5804
organism: BioSource1

http://identifiers.org/pubmed/20171863
type: PublicationXref
id: 20171863
author: Savina, A
author: Amigorena, S
db: Pubmed
title: Intracellular mechanisms of antigen cross presentation in dendritic cells
source: Curr Opin Immunol 22:109-17
year: 2010

UniProt:Q8IAX6
type: ProteinReference
xref: UnificationXref1102
organism: BioSource1

UniProt:Q8IAX5
type: ProteinReference
xref: UnificationXref1009
organism: BioSource1

SequenceSite298
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite297
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite296
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite295
type: SequenceSite
position status: EQUAL
sequence position: 1325

FRS2-mediated cascade
type: Pathway
data source: Provenance1
pathway component: REACT 157443.3
evidence: Evidence21
xref: UnificationXref214
xref: UnificationXref213
pathway order: PathwayStep16
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite299
type: SequenceSite
position status: EQUAL
sequence position: 1325

UniProt:Q8IAZ8
type: ProteinReference
xref: UnificationXref3103
organism: BioSource1

UniProt:Q8IAZ3
type: ProteinReference
xref: UnificationXref3702
organism: BioSource1

Iron uptake and transport
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction26
pathway component: REACT 140389.5
evidence: Evidence103
xref: UnificationXref795
xref: UnificationXref796
xref: RelationshipXref72
pathway order: PathwayStep83
pathway order: PathwayStep100
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite270
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite272
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite271
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite262
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite263
type: SequenceSite
position status: EQUAL
sequence position: 842

SequenceSite264
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite265
type: SequenceSite
position status: EQUAL
sequence position: 842

SequenceSite266
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite267
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite268
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite269
type: SequenceSite
position status: EQUAL
sequence position: 1325

http://identifiers.org/pubmed/16319917
type: PublicationXref
id: 16319917
author: Newman, SC
author: Radomski, MW
author: Jurasz, P
author: Lara, N
author: Le Mellédo, JM
author: Baker, G
author: Archer, SL
author: Chrapko, W
db: Pubmed
title: Alteration of decreased plasma NO metabolites and platelet NO synthase activity by paroxetine in depressed patients
source: Neuropsychopharmacology 31:1286-93
year: 2006

UniProt:Q8IB51
type: ProteinReference
xref: UnificationXref1125
organism: BioSource1

PublicationXref546
type: PublicationXref
id: 978-0-444-53219-0
author: Vance, DE
author: Vance, JE
db: ISBN
title: Phospholipid biosynthesis in eukaryotes
source: Biochemistry of Lipids, Lipoproteins and Membranes, 5th Edition (Book): 213-244
year: 2008

SequenceSite261
type: SequenceSite
position status: EQUAL
sequence position: 842

SequenceSite260
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q8IB57
type: ProteinReference
xref: UnificationXref4622
organism: BioSource1

SequenceSite253
type: SequenceSite
position status: EQUAL
sequence position: 1480

http://identifiers.org/pubmed/16788062
type: PublicationXref
id: 16788062
author: Schwer, B
author: Verdin, E
author: Andersen, JS
author: Verdin, RO
author: Bunkenborg, J
db: Pubmed
title: Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
source: Proc Natl Acad Sci U S A 103:10224-9
year: 2006

SequenceSite254
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite251
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite252
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9587671
type: PublicationXref
id: 9587671
author: Schwimmer, C
author: Le Saux, A
author: Vignais, PV
author: Trezeguet, V
author: Fiore, C
author: Lauquin, GJ
author: Roux, P
author: Brandolin, G
author: Noel, F
author: Dianoux, AC
db: Pubmed
title: The mitochondrial ADP/ATP carrier: structural, physiological and
source: Biochimie 80:137-50
year: 1998

SequenceSite257
type: SequenceSite
position status: EQUAL
sequence position: 842

SequenceSite258
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite255
type: SequenceSite
position status: EQUAL
sequence position: 842

SequenceSite256
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/12881475
type: PublicationXref
id: 12881475
author: Koesling, D
author: Friebe, A
db: Pubmed
title: Regulation of nitric oxide-sensitive guanylyl cyclase
source: Circ Res 93:96-105
year: 2003

SequenceSite259
type: SequenceSite
position status: EQUAL
sequence position: 842

UniProt:Q8IB60
type: ProteinReference
xref: UnificationXref4316
organism: BioSource1

http://identifiers.org/pubmed/22013531
type: PublicationXref
id: 22013531
author: Alves, S
author: Coutinho, MF
author: Lacerda, L
db: Pubmed
title: Glycosaminoglycan storage disorders: a review
source: Biochem Res Int 2012:471325
year: 2012

SequenceSite292
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite291
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite294
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite293
type: SequenceSite
position status: EQUAL
sequence position: 1325

http://identifiers.org/pubmed/11435118
type: PublicationXref
id: 11435118
author: Timm, DE
author: Harris, RA
author: Dorocke, JA
author: Baker, LJ
db: Pubmed
title: The crystal structure of yeast thiamin pyrophosphokinase
source: Structure 9:539-46
year: 2001

SequenceSite290
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite288
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite289
type: SequenceSite
position status: EQUAL
sequence position: 1325

Lipoprotein metabolism
type: Pathway
data source: Provenance1
pathway component: HDL-mediated lipid transport
evidence: Evidence187
xref: UnificationXref1614
xref: RelationshipXref152
xref: UnificationXref1613
pathway order: PathwayStep181
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite284
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite285
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite286
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite287
type: SequenceSite
position status: EQUAL
sequence position: 1325

UniProt:Q8IB73
type: ProteinReference
xref: UnificationXref1329
organism: BioSource1

http://identifiers.org/pubmed/10783391
type: PublicationXref
id: 10783391
author: Gabel, CA
author: Schulte, GK
author: Hoth, LR
author: Chelvanayagam, G
author: Chrunyk, BA
author: Geoghegan, KF
author: Coggan, M
author: Easteal, S
author: Kamath, AV
author: Board, PG
author: Jermiin, LS
author: Pandit, J
author: Rosner, MH
author: Perregaux, DE
author: Danley, DE
author: Griffor, MC
db: Pubmed
title: Identification, characterization, and crystal structure of the Omega class glutathione transferases
source: J Biol Chem 275:24798-806
year: 2000

http://identifiers.org/pubmed/16543383
type: PublicationXref
id: 16543383
author: Pollard, JW
author: Pollack, SE
author: Cohen, PE
db: Pubmed
title: Genetic analysis of chromosome pairing, recombination, and cell cycle control during first meiotic prophase in mammals
source: Endocr Rev 27:398-426
year: 2006

SequenceSite283
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite282
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite281
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite280
type: SequenceSite
position status: EQUAL
sequence position: 1

Heme biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction225
pathway component: BiochemicalReaction227
pathway component: BiochemicalReaction220
pathway component: BiochemicalReaction226
pathway component: BiochemicalReaction224
pathway component: BiochemicalReaction222
pathway component: BiochemicalReaction228
pathway component: BiochemicalReaction223
pathway component: BiochemicalReaction221
pathway component: BiochemicalReaction219
evidence: Evidence409
xref: UnificationXref3517
xref: UnificationXref3516
xref: RelationshipXref439
pathway order: PathwayStep395
pathway order: PathwayStep396
pathway order: PathwayStep401
pathway order: PathwayStep402
pathway order: PathwayStep398
pathway order: PathwayStep397
pathway order: PathwayStep399
pathway order: PathwayStep400
pathway order: PathwayStep394
pathway order: PathwayStep403
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite279
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite277
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite278
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite275
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite276
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite273
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite274
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/10488948
type: PublicationXref
id: 10488948
author: Barter, PJ
author: Clay, MA
author: Rye, KA
db: Pubmed
title: Remodelling of high density lipoproteins by plasma factors
source: Atherosclerosis 145:227-38
year: 1999

Translocation of GLUT4 to the Plasma Membrane
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction296
evidence: Evidence566
xref: UnificationXref4553
xref: UnificationXref4552
pathway order: PathwayStep551
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1601
type: UnificationXref
id: CHEBI:17504
db: ChEBI

UnificationXref1602
type: UnificationXref
id: 194236
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194236

UnificationXref1603
type: UnificationXref
id: REACT_14615
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14615.2

UnificationXref1604
type: UnificationXref
id: CHEBI:17002
db: ChEBI

UnificationXref1605
type: UnificationXref
id: 171076
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=171076

UnificationXref1606
type: UnificationXref
id: REACT_7527
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7527.2

UnificationXref1607
type: UnificationXref
id: C6KTC8
db: UniProt

UnificationXref1608
type: UnificationXref
id: 3655235
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655235

UnificationXref1609
type: UnificationXref
id: 3655237
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655237

http://identifiers.org/pubmed/11498013
type: PublicationXref
id: 11498013
author: Sorkin, A
db: Pubmed
title: Internalization of the epidermal growth factor receptor: role in signalling
source: Biochem Soc Trans 29:480-4
year: 2001

dITP
type: SmallMoleculeReference
name: 2'-Deoxyinosine 5'-triphosphate
name: dITP [ChEBI:10499]
name: 2'-Deoxyinosine-5'-triphosphate
xref: UnificationXref2986

2'-Deoxyinosine 5'-phosphate [ChEBI:28806]
type: SmallMoleculeReference
name: 2'-Deoxyinosine 5'-phosphate
name: dIMP
xref: UnificationXref2989

http://identifiers.org/pubmed/9878253
type: PublicationXref
id: 9878253
author: Ianna, P
author: Zeviani, M
author: Carrozzo, R
author: Fernandez, P
author: Petruzzella, V
author: Tiranti, V
db: Pubmed
title: Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain
source: Genomics 54:494-504
year: 1998

http://identifiers.org/pubmed/22653731
type: PublicationXref
id: 22653731
author: Levin, Aron M
author: Waghray, Deepa
author: Thomas, Christoph
author: Garcia, K Christopher
author: Janda, Claudia Y
db: Pubmed
title: Structural basis of Wnt recognition by Frizzled
source: Science 337:59-64
year: 2012

http://identifiers.org/pubmed/9218123
type: PublicationXref
id: 9218123
author: Pasternak, GW
author: Standifer, KM
db: Pubmed
title: G proteins and opioid receptor-mediated signalling
source: Cell Signal 9:237-48
year: 1997

UnificationXref1611
type: UnificationXref
id: 3657408
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657408

UnificationXref1610
type: UnificationXref
id: REACT_30501
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30501.10

UnificationXref1600
type: UnificationXref
id: REACT_14183
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14183.1

http://identifiers.org/pubmed/10903473
type: PublicationXref
id: 10903473
author: Sprecher, H
db: Pubmed
title: Metabolism of highly unsaturated n-3 and n-6 fatty acids
source: Biochim Biophys Acta 1486:219-31
year: 2000

UniProt:Q8IBB3
type: ProteinReference
xref: UnificationXref5464
organism: BioSource1

http://identifiers.org/pubmed/18802471
type: PublicationXref
id: 18802471
author: Jefferies, WA
author: Seipp, RP
author: Basha, G
author: Omilusik, KD
author: Lizée, G
author: Reinicke, AT
db: Pubmed
title: MHC class I endosomal and lysosomal trafficking coincides with exogenous antigen loading in dendritic cells
source: PLoS One 3:e3247
year: 2008

PublicationXref536
type: PublicationXref
author: Marmer, WN
author: Piazza, GJ
title: Conversion of Phosphatidylcholine to Phosphatidylglycerol with Phospholipase D and glycerol
source: J. Amer. Oil Chem. Soc. 84:6465-651
year: 2007

http://identifiers.org/pubmed/18653779
type: PublicationXref
id: 18653779
author: Sandahl, MA
author: Miraglia, L
author: Hunter, D
author: Earp HS, 3rd
author: Muraoka-Cook, RS
db: Pubmed
title: Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation
source: Mol Endocrinol 22:2307-21
year: 2008

EIF5A2(2-153)
type: Protein
entity reference: UniProt:Q8MX76
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q8MX76
name: Eukaryotic tranlation initiation factor 5A2
xref: UnificationXref4126
feature: FragmentFeature761
cellular location: GO:0005829
comment: Reactome DB_ID: 3655169
display name: EIF5A2

Homologues of EIF5A2(2-153)
type: Protein
data source: Provenance1
member physical entity: EIF5A2(2-153)
xref: UnificationXref4128
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3655171

dCDP
type: SmallMoleculeReference
name: dCDP [ChEBI:28846]
name: 2'-Deoxycytidine diphosphate
name: 2'-Deoxycytidine 5'-diphosphate
xref: UnificationXref2810

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I603
data source: Provenance1
name: Eukaryotic translation initiation factor 5A-1
name: Dhp50
name: Q8I603
name: IF5A1_HUMAN
xref: UnificationXref4124
feature: FragmentFeature760
cellular location: GO:0005829
comment: Reactome DB_ID: 3655167
display name: EIF5A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8MX76
data source: Provenance1
name: Q8MX76
name: Eukaryotic translation initiation factor 5A-1
name: Dhp50
name: IF5A1_HUMAN
xref: UnificationXref4122
feature: FragmentFeature759
cellular location: GO:0005829
comment: Reactome DB_ID: 3655166
display name: EIF5A

UniProt:Q968W4
type: ProteinReference
xref: UnificationXref2472
organism: BioSource1

Signalling to ERKs
type: Pathway
data source: Provenance1
pathway component: REACT 153434.3
pathway component: Signalling to p38 via RIT and RIN
pathway component: Signalling to RAS
evidence: Evidence816
xref: UnificationXref6003
xref: UnificationXref6002
pathway order: PathwayStep786
pathway order: PathwayStep785
pathway order: PathwayStep789
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/17463226
type: PublicationXref
id: 17463226
author: Puggioni, EM
author: Cesareni, G
author: Gulino, A
author: Santangelo, L
author: Belleudi, F
author: Palumbo, C
author: Frati, L
author: Marrocco, J
author: Omerovic, J
author: Torrisi, MR
author: Di Marcotullio, L
author: Alimandi, M
author: Dall'Armi, C
db: Pubmed
title: The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation
source: FASEB J 21:2849-62
year: 2007

http://identifiers.org/pubmed/10092647
type: PublicationXref
id: 10092647
author: Wang, X
author: Nowatzke, W
author: Ramanadham, S
author: Ma, Z
author: Turk, J
db: Pubmed
title: Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1
source: J Biol Chem 274:9607-16
year: 1999

http://identifiers.org/pubmed/14627435
type: PublicationXref
id: 14627435
author: Agius, L
author: Brocklehurst, KJ
author: Davies, RA
db: Pubmed
title: Differences in regulatory properties between human and rat glucokinase regulatory protein
source: Biochem J 378:693-7
year: 2004

dUDP [ChEBI:28850]
type: SmallMoleculeReference
name: 2'-Deoxyuridine 5'-diphosphate
name: dUDP
xref: UnificationXref2829

http://identifiers.org/pubmed/14671330
type: PublicationXref
id: 14671330
author: McRee, DE
author: Ribas de Pouplana, L
author: Otero, FJ
author: Yang, XL
author: Schimmel, P
author: Skene, RJ
db: Pubmed
title: Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
source: Proc Natl Acad Sci U S A 100:15376-80
year: 2003

http://identifiers.org/pubmed/12495737
type: PublicationXref
id: 12495737
author: Elliott, T
author: Antoniou, AN
author: Powis, SJ
db: Pubmed
title: Assembly and export of MHC class I peptide ligands
source: Curr Opin Immunol 15:75-81
year: 2003

http://identifiers.org/pubmed/3391615
type: PublicationXref
id: 3391615
author: Robertson, D A
author: Baker, E G
author: Morris, C P
author: Hopwood, J J
author: Callen, D F
db: Pubmed
title: Chromosomal localization of the gene for human glucosamine-6-sulphatase to 12q14
source: Hum. Genet. 79:175-8
year: 1988

http://identifiers.org/pubmed/17478478
type: PublicationXref
id: 17478478
author: Ozbal, CC
author: Lamarr, WA
author: Gedrich, RW
author: Landro, JA
author: Lumb, KJ
author: Toth, JG
author: Osterman, DG
author: Forbes, CD
author: Rocks, S
author: Pendleton, JA
db: Pubmed
title: High-throughput mass spectrometry screening for inhibitors of phosphatidylserine decarboxylase
source: J Biomol Screen 12:628-34
year: 2007

UnificationXref1660
type: UnificationXref
id: Q8IK56
db: UniProt

UnificationXref1662
type: UnificationXref
id: Q8I535
db: UniProt

UnificationXref1661
type: UnificationXref
id: 3654048
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654048

http://identifiers.org/pubmed/17132865
type: PublicationXref
id: 17132865
author: Hirabayashi, Y
author: Horibata, Y
db: Pubmed
title: Identification and characterization of human ethanolaminephosphotransferase1
source: J Lipid Res 48:503-8
year: 2007

UnificationXref1664
type: UnificationXref
id: C0H5N0
db: UniProt

UnificationXref1663
type: UnificationXref
id: 3654052
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654052

UnificationXref1666
type: UnificationXref
id: O96230
db: UniProt

UnificationXref1665
type: UnificationXref
id: 3654056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654056

http://identifiers.org/pubmed/9208814
type: PublicationXref
id: 9208814
author: Anwar, R
author: Gilbey, SG
author: Markham, AF
author: New, JP
db: Pubmed
title: Male pseudohermaphroditism resulting from a novel mutation in the human steroid 5 alpha-reductase type 2 gene (SRD5A2)
source: Mol Pathol 50:51-2
year: 1997

http://identifiers.org/pubmed/14702636
type: PublicationXref
id: 14702636
author: Lyden, D
author: Liao, F
author: Hackett, NR
author: Witte, L
author: Heissig, B
author: Crystal, RG
author: Shido, K
author: Dias, S
author: Hattori, K
author: de Sauvage, F
author: Hartman, TE
author: Jin, DK
author: Eaton, D
author: Hicklin, DJ
author: Bohlen, P
author: Rafii, S
author: Avecilla, ST
author: Tejada, R
author: Zhang, F
db: Pubmed
title: Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
source: Nat Med 10:64-71
year: 2004

UnificationXref1656
type: UnificationXref
id: O97330
db: UniProt

UnificationXref1657
type: UnificationXref
id: 3654042
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654042

UnificationXref1658
type: UnificationXref
id: Q9U8K3
db: UniProt

UnificationXref1659
type: UnificationXref
id: 3654044
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654044

UnificationXref1673
type: UnificationXref
id: 3654068
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654068

UnificationXref1672
type: UnificationXref
id: Q02602
db: UniProt

UnificationXref1671
type: UnificationXref
id: 3654066
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654066

UnificationXref1670
type: UnificationXref
id: Q25708
db: UniProt

UnificationXref1677
type: UnificationXref
id: 3654076
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654076

UnificationXref1676
type: UnificationXref
id: O96232
db: UniProt

UnificationXref1675
type: UnificationXref
id: 3654072
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654072

UnificationXref1674
type: UnificationXref
id: Q8I638
db: UniProt

2'-Deoxyguanosine 5'-diphosphate
type: SmallMoleculeReference
name: dGDP [ChEBI:28862]
name: dGDP
xref: UnificationXref2794

UnificationXref1669
type: UnificationXref
id: 3654064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654064

UnificationXref1667
type: UnificationXref
id: 3654060
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654060

UnificationXref1668
type: UnificationXref
id: Q8I6Z1
db: UniProt

UnificationXref1686
type: UnificationXref
id: 548819
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=548819

UnificationXref1685
type: UnificationXref
id: CHEBI:15514
db: ChEBI

http://identifiers.org/pubmed/19923268
type: PublicationXref
id: 19923268
author: Wang, Yonggang
author: Dasso, Mary
db: Pubmed
title: SUMOylation and deSUMOylation at a glance
source: J. Cell. Sci. 122:4249-52
year: 2009

UnificationXref1688
type: UnificationXref
id: 3656103
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656103

UnificationXref1687
type: UnificationXref
id: REACT_22603
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22603.1

UnificationXref1682
type: UnificationXref
id: CHEBI:15843
db: ChEBI

UnificationXref1681
type: UnificationXref
id: REACT_113433
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113433.8

UnificationXref1684
type: UnificationXref
id: REACT_15656
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15656.2

UnificationXref1683
type: UnificationXref
id: 29768
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29768

UnificationXref1680
type: UnificationXref
id: 3654080
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654080

http://identifiers.org/pubmed/17125408
type: PublicationXref
id: 17125408
author: Baltes, E
author: Strolin Benedetti, M
author: Whomsley, R
db: Pubmed
title: Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics
source: Expert Opin Drug Metab Toxicol 2:895-921
year: 2006

UnificationXref1678
type: UnificationXref
id: 3654077
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654077

UnificationXref1679
type: UnificationXref
id: 3654078
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654078

UnificationXref1699
type: UnificationXref
id: CHEBI:52974
db: ChEBI

UnificationXref1698
type: UnificationXref
id: 3656087
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656087

UnificationXref1697
type: UnificationXref
id: 3656085
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656085

UnificationXref1696
type: UnificationXref
id: REACT_128661
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128661.5

UnificationXref1695
type: UnificationXref
id: 3656090
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656090

UnificationXref1694
type: UnificationXref
id: 3656088
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656088

UnificationXref1693
type: UnificationXref
id: C6KSQ7
db: UniProt

UnificationXref1692
type: UnificationXref
id: REACT_22457
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22457.1

UnificationXref1691
type: UnificationXref
id: 548812
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=548812

UnificationXref1690
type: UnificationXref
id: CHEBI:50571
db: ChEBI

UniProt:Q8MX76
type: ProteinReference
xref: UnificationXref4121
organism: BioSource1

http://identifiers.org/pubmed/641056
type: PublicationXref
id: 641056
author: Hershey, JW
author: Benne, R
db: Pubmed
title: The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.
source: J Biol Chem 253:3078-87
year: 1978

http://identifiers.org/pubmed/10970790
type: PublicationXref
id: 10970790
author: Chuang, LT
author: Bobik, EG
author: Das, T
author: Mukerji, P
author: Parker-Barnes, JM
author: Thurmond, JM
author: Leonard, AE
author: Dorado, J
author: Kroeger, PE
author: Huang, YS
db: Pubmed
title: Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids
source: Biochem J 350:765-70
year: 2000

UnificationXref1689
type: UnificationXref
id: REACT_81943
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81943.9

SequenceSite2311
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2310
type: SequenceSite
position status: EQUAL
sequence position: 1325

UnificationXref1620
type: UnificationXref
id: Q8IKE1
db: UniProt

UnificationXref1621
type: UnificationXref
id: MOD:00126
db: MOD

UnificationXref1622
type: UnificationXref
id: 3654015
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654015

SequenceSite2318
type: SequenceSite
position status: EQUAL
sequence position: 1325

UnificationXref1613
type: UnificationXref
id: 3657409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657409

SequenceSite2319
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref1612
type: UnificationXref
id: REACT_96211
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96211.9

http://identifiers.org/pubmed/3355497
type: PublicationXref
id: 3355497
author: Fothergill-Gilmore, LA
author: Dunbar, B
db: Pubmed
title: The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase
source: Biochem J 249:779-88
year: 1988

SequenceSite2316
type: SequenceSite
position status: EQUAL
sequence position: 1325

UnificationXref1615
type: UnificationXref
id: 3657410
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3657410

SequenceSite2317
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1614
type: UnificationXref
id: REACT_88824
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88824.9

SequenceSite2314
type: SequenceSite
position status: EQUAL
sequence position: 1325

UnificationXref1617
type: UnificationXref
id: CHEBI:15531
db: ChEBI

SequenceSite2315
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1616
type: UnificationXref
id: REACT_79244
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79244.9

SequenceSite2312
type: SequenceSite
position status: EQUAL
sequence position: 1325

UnificationXref1619
type: UnificationXref
id: REACT_3059
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3059.1

SequenceSite2313
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1618
type: UnificationXref
id: 29508
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29508

http://identifiers.org/pubmed/1976634
type: PublicationXref
id: 1976634
author: Hurwitz, J
author: Lee, SH
author: Kwong, AD
db: Pubmed
title: The in vitro replication of DNA containing the SV40 origin.
source: J Biol Chem 265:18043-6
year: 1990

http://identifiers.org/pubmed/17591783
type: PublicationXref
id: 17591783
author: Cao, John T
author: Salvesen, Guy S
author: Drag, M
author: Békés, Miklós
author: Mikolajczyk, Jowita
author: Ronai, Ze'ev
db: Pubmed
title: Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs
source: J. Biol. Chem. 282:26217-24
year: 2007

http://identifiers.org/pubmed/19926846
type: PublicationXref
id: 19926846
author: Saitoh, T
author: Hayashi, Takuya
author: Matsunaga, Kohichi
author: Lee, Hanna
author: Satoh, T
author: Akira, S
author: Takeuchi, O
author: Noda, Takeshi
author: Ishii, Ken
author: Fujita, Naonobu
author: Kageyama, Shun
author: Takahara, Keigo
author: Omori, Hiroko
author: Kawai, T
author: Yamamoto, Naoki
author: Yoshimori, Tamotsu
db: Pubmed
title: Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
source: Proc. Natl. Acad. Sci. U.S.A. 106:20842-6
year: 2009

SequenceSite2300
type: SequenceSite
position status: EQUAL
sequence position: 1325

UnificationXref1632
type: UnificationXref
id: CHEBI:15346
db: ChEBI

UnificationXref1633
type: UnificationXref
id: 76194
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76194

UnificationXref1630
type: UnificationXref
id: 76190
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76190

UnificationXref1631
type: UnificationXref
id: REACT_2769
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2769.2

SequenceSite2305
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1626
type: UnificationXref
id: 3655029
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655029

SequenceSite2306
type: SequenceSite
position status: EQUAL
sequence position: 1325

UnificationXref1625
type: UnificationXref
id: 3654019
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654019

SequenceSite2307
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1624
type: UnificationXref
id: 3654018
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654018

SequenceSite2308
type: SequenceSite
position status: EQUAL
sequence position: 1325

UnificationXref1623
type: UnificationXref
id: Q9U752
db: UniProt

SequenceSite2301
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2302
type: SequenceSite
position status: EQUAL
sequence position: 1325

UnificationXref1629
type: UnificationXref
id: CHEBI:30769
db: ChEBI

SequenceSite2303
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1628
type: UnificationXref
id: 3655030
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3655030

SequenceSite2304
type: SequenceSite
position status: EQUAL
sequence position: 1325

UnificationXref1627
type: UnificationXref
id: REACT_131212
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131212.5

SequenceSite2309
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1641
type: UnificationXref
id: REACT_2677
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2677.2

UnificationXref1642
type: UnificationXref
id: CHEBI:15525
db: ChEBI

UnificationXref1643
type: UnificationXref
id: 200993
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=200993

UnificationXref1644
type: UnificationXref
id: REACT_11391
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11391.2

SequenceSite2333
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2332
type: SequenceSite
position status: EQUAL
sequence position: 448

SequenceSite2331
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/19244215
type: PublicationXref
id: 19244215
author: Buczynski, MW
author: Dumlao, DS
author: Dennis, EA
db: Pubmed
title: Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology
source: J Lipid Res 50:1015-38
year: 2009

SequenceSite2330
type: SequenceSite
position status: EQUAL
sequence position: 448

UnificationXref1640
type: UnificationXref
id: 76577
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76577

SequenceSite2336
type: SequenceSite
position status: EQUAL
sequence position: 149

UnificationXref1639
type: UnificationXref
id: CHEBI:16027
db: ChEBI

SequenceSite2337
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref1638
type: UnificationXref
id: REACT_3374
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3374.3

SequenceSite2334
type: SequenceSite
position status: EQUAL
sequence position: 448

SequenceSite2335
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref1635
type: UnificationXref
id: GO:0005769
db: GENE ONTOLOGY

http://identifiers.org/pubmed/12648452
type: PublicationXref
id: 12648452
author: Buttgereit, F
author: Qian, SB
author: Finzi, D
author: Princiotta, MF
author: Yewdell, JW
author: Gibbs, J
author: Bennink, JR
author: Schuchmann, S
db: Pubmed
title: Quantitating protein synthesis, degradation, and endogenous antigen processing
source: Immunity 18:343-54
year: 2003

UnificationXref1634
type: UnificationXref
id: REACT_2732
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2732.2

SequenceSite2338
type: SequenceSite
position status: EQUAL
sequence position: 149

UnificationXref1637
type: UnificationXref
id: 76168
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76168

SequenceSite2339
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1636
type: UnificationXref
id: CHEBI:15756
db: ChEBI

http://identifiers.org/pubmed/17371050
type: PublicationXref
id: 17371050
author: Kondo, N
author: Fukao, T
author: Haapalainen, AM
author: Wierenga, RK
author: Meriläinen, G
author: Pirilä, PL
db: Pubmed
title: Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function
source: Biochemistry 46:4305-21
year: 2007

UnificationXref1654
type: UnificationXref
id: Q9U5A6
db: UniProt

UnificationXref1655
type: UnificationXref
id: 3654038
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654038

UnificationXref1652
type: UnificationXref
id: Q7KQL7
db: UniProt

UnificationXref1653
type: UnificationXref
id: 3654036
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654036

SequenceSite2320
type: SequenceSite
position status: EQUAL
sequence position: 364

UnificationXref1650
type: UnificationXref
id: Q8I0V8
db: UniProt

http://identifiers.org/pubmed/17379924
type: PublicationXref
id: 17379924
author: Kinoshita, T
author: Onoduka, J
author: Mori, M
author: Homma, KJ
author: Yamashita, A
author: Itabe, H
author: Makita, M
author: Yamaguchi, S
author: Fujimoto, Y
author: Takano, T
author: Higashi, Y
db: Pubmed
title: Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7
source: J Lipid Res 48:1280-92
year: 2007

UnificationXref1651
type: UnificationXref
id: 3654034
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654034

SequenceSite2322
type: SequenceSite
position status: EQUAL
sequence position: 364

SequenceSite2321
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2323
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2324
type: SequenceSite
position status: EQUAL
sequence position: 364

SequenceSite2325
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2326
type: SequenceSite
position status: EQUAL
sequence position: 364

UnificationXref1649
type: UnificationXref
id: 3654030
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654030

SequenceSite2327
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1648
type: UnificationXref
id: Q9TY41
db: UniProt

SequenceSite2328
type: SequenceSite
position status: EQUAL
sequence position: 1205

UnificationXref1647
type: UnificationXref
id: 3654026
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3654026

SequenceSite2329
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1646
type: UnificationXref
id: Q8I0X2
db: UniProt

UnificationXref1645
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

http://identifiers.org/pubmed/11698644
type: PublicationXref
id: 11698644
author: Kabashima, T
author: Uyeda, K
author: Kawaguchi, T
author: Takenoshita, M
db: Pubmed
title: Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein
source: Proc Natl Acad Sci U S A 98:13710-5
year: 2001

SequenceSite111
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite110
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite113
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/14551214
type: PublicationXref
id: 14551214
author: Blanck, TJ
author: Xu, Y
author: Kelley, RI
author: Schlame, M
db: Pubmed
title: Remodeling of cardiolipin by phospholipid transacylation
source: J Biol Chem 278:51380-5
year: 2003

SequenceSite112
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite115
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite114
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite117
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite116
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite119
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite118
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite2357
type: SequenceSite
position status: EQUAL
sequence position: 19

Ion channel transport
type: Pathway
data source: Provenance1
pathway component: REACT 153390.3
evidence: Evidence107
xref: RelationshipXref75
xref: UnificationXref824
xref: UnificationXref823
pathway order: PathwayStep104
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite2356
type: SequenceSite
position status: EQUAL
sequence position: 315

SequenceSite2359
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2358
type: SequenceSite
position status: EQUAL
sequence position: 654

SequenceSite2352
type: SequenceSite
position status: EQUAL
sequence position: 315

PKA activation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction5
evidence: Evidence8
xref: RelationshipXref12
xref: UnificationXref179
xref: UnificationXref178
pathway order: PathwayStep7
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite2353
type: SequenceSite
position status: EQUAL
sequence position: 20

SequenceSite2354
type: SequenceSite
position status: EQUAL
sequence position: 315

SequenceSite2355
type: SequenceSite
position status: EQUAL
sequence position: 20

SequenceSite2350
type: SequenceSite
position status: EQUAL
sequence position: 315

SequenceSite2351
type: SequenceSite
position status: EQUAL
sequence position: 20

L-deoxyhypusine
type: SequenceModificationVocabulary
xref: UnificationXref4133

http://identifiers.org/pubmed/17656326
type: PublicationXref
id: 17656326
author: Ardehali, H
author: Burke, MA
db: Pubmed
title: Mitochondrial ATP-binding cassette proteins
source: Transl Res 150:73-80
year: 2007

SequenceSite122
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite121
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite120
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite126
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite125
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite124
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite123
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite129
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite128
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite2349
type: SequenceSite
position status: EQUAL
sequence position: 20

SequenceSite127
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2348
type: SequenceSite
position status: EQUAL
sequence position: 315

SequenceSite2347
type: SequenceSite
position status: EQUAL
sequence position: 20

SequenceSite2346
type: SequenceSite
position status: EQUAL
sequence position: 315

SequenceSite2345
type: SequenceSite
position status: EQUAL
sequence position: 20

SequenceSite2343
type: SequenceSite
position status: EQUAL
sequence position: 20

SequenceSite2344
type: SequenceSite
position status: EQUAL
sequence position: 315

SequenceSite2341
type: SequenceSite
position status: EQUAL
sequence position: 20

SequenceSite2342
type: SequenceSite
position status: EQUAL
sequence position: 315

SequenceSite2340
type: SequenceSite
position status: EQUAL
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SequenceSite2379
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2378
type: SequenceSite
position status: EQUAL
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SequenceSite2370
type: SequenceSite
position status: EQUAL
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SequenceSite2371
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2372
type: SequenceSite
position status: EQUAL
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SequenceSite2373
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2374
type: SequenceSite
position status: EQUAL
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SequenceSite2375
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2376
type: SequenceSite
position status: EQUAL
sequence position: 95

SequenceSite2377
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite104
type: SequenceSite
position status: EQUAL
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SequenceSite103
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite102
type: SequenceSite
position status: EQUAL
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SequenceSite101
type: SequenceSite
position status: EQUAL
sequence position: 259

SequenceSite100
type: SequenceSite
position status: EQUAL
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SequenceSite2369
type: SequenceSite
position status: EQUAL
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SequenceSite2368
type: SequenceSite
position status: EQUAL
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SequenceSite2367
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite109
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite108
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite107
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite106
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite105
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2361
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2362
type: SequenceSite
position status: EQUAL
sequence position: 277

SequenceSite2360
type: SequenceSite
position status: EQUAL
sequence position: 286

SequenceSite2365
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2366
type: SequenceSite
position status: EQUAL
sequence position: 2698

SequenceSite2363
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2364
type: SequenceSite
position status: EQUAL
sequence position: 665

http://identifiers.org/pubmed/12807903
type: PublicationXref
id: 12807903
author: Nagai, M
author: Sudol, M
author: Navin, NE
author: Komuro, A
db: Pubmed
title: WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
source: J Biol Chem 278:33334-41
year: 2003

Formation of a pool of free 40S subunits
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction243
evidence: Evidence454
xref: UnificationXref3769
xref: UnificationXref3768
pathway order: PathwayStep440
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite2391
type: SequenceSite
position status: EQUAL
sequence position: 158

SequenceSite2390
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2397
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2396
type: SequenceSite
position status: EQUAL
sequence position: 1290

SequenceSite2399
type: SequenceSite
position status: EQUAL
sequence position: 43

SequenceSite2398
type: SequenceSite
position status: EQUAL
sequence position: 152

SequenceSite2393
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2392
type: SequenceSite
position status: EQUAL
sequence position: 93

SequenceSite2395
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2394
type: SequenceSite
position status: EQUAL
sequence position: 158

SequenceSite2389
type: SequenceSite
position status: EQUAL
sequence position: 640

SequenceSite2380
type: SequenceSite
position status: EQUAL
sequence position: 103

http://identifiers.org/pubmed/8331657
type: PublicationXref
id: 8331657
author: Huber, R
author: Reinemer, P
author: Cowan, S W
author: Board, P G
author: Gilliland, G L
author: Armstrong, R N
author: Dirr, H W
author: Ji, X
author: Sinning, I
author: Kleywegt, G J
db: Pubmed
title: Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes
source: J. Mol. Biol. 232:192-212
year: 1993

SequenceSite2388
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2387
type: SequenceSite
position status: EQUAL
sequence position: 173

SequenceSite2386
type: SequenceSite
position status: EQUAL
sequence position: 346

SequenceSite2385
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2384
type: SequenceSite
position status: EQUAL
sequence position: 640

SequenceSite2383
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2382
type: SequenceSite
position status: EQUAL
sequence position: 92

SequenceSite2381
type: SequenceSite
position status: EQUAL
sequence position: 1

Processing and Activation of SUMO
type: Pathway
data source: Provenance1
pathway component: REACT 168507.1
pathway component: Proteolytic Processing of SUMO
pathway component: REACT 168682.1
evidence: Evidence761
xref: RelationshipXref630
xref: UnificationXref5782
xref: UnificationXref5781
pathway order: PathwayStep730
pathway order: PathwayStep736
pathway order: PathwayStep734
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/12876557
type: PublicationXref
id: 12876557
author: Schneider, H
author: Rudd, CE
db: Pubmed
title: Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling
source: Nat Rev Immunol 3:544-56
year: 2003

http://identifiers.org/pubmed/19647993
type: PublicationXref
id: 19647993
author: Shental-Bechor, D
author: Levy, Y
db: Pubmed
title: Folding of glycoproteins: toward understanding the biophysics of the glycosylation code
source: Curr Opin Struct Biol 19:524-33
year: 2009

Cobalamin (Cbl, vitamin B12) transport and metabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction199
evidence: Evidence367
xref: UnificationXref3123
xref: RelationshipXref382
xref: UnificationXref3124
pathway order: PathwayStep361
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/8535439
type: PublicationXref
id: 8535439
author: Tolan, DR
db: Pubmed
title: Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene
source: Hum Mutat 6:210-8
year: 1995

Synthesis of glycosylphosphatidylinositol (GPI)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction278
pathway component: BiochemicalReaction277
pathway component: BiochemicalReaction279
pathway component: BiochemicalReaction276
evidence: Evidence510
xref: UnificationXref4220
xref: UnificationXref4221
xref: RelationshipXref501
pathway order: PathwayStep493
pathway order: PathwayStep496
pathway order: PathwayStep495
pathway order: PathwayStep494
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10745013
type: PublicationXref
id: 10745013
author: Gover, S
author: Lam, VM
author: Au, SW
author: Adams, MJ
db: Pubmed
title: Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP(+) molecule and provides insights into enzyme deficiency
source: Structure 8:293-303
year: 2000

http://identifiers.org/pubmed/16100110
type: PublicationXref
id: 16100110
author: Jigami, Y
author: Sato, T
author: Gao, XD
author: Tachikawa, H
author: Dean, N
db: Pubmed
title: Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation
source: J Biol Chem 280:36254-62
year: 2005

Gap-filling DNA repair synthesis and ligation in TC-NER
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction357
evidence: Evidence695
xref: UnificationXref5334
xref: UnificationXref5333
pathway order: PathwayStep675
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/14567916
type: PublicationXref
id: 14567916
author: DiCorleto, PE
author: Maitra, RK
author: Fox, PL
author: Sampath, P
author: Seshadri, V
author: Mazumder, B
db: Pubmed
title: Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control
source: Cell 115:187-98
year: 2003

SequenceSite199
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite198
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/16100120
type: PublicationXref
id: 16100120
author: Lahiri, S
author: Futerman, AH
db: Pubmed
title: LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor
source: J Biol Chem 280:33735-8
year: 2005

SequenceSite197
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite196
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/4335615
type: PublicationXref
id: 4335615
author: Fielding, PE
author: Shore, VG
author: Fielding, CJ
db: Pubmed
title: A protein cofactor of lecithin:cholesterol acyltransferase
source: Biochem Biophys Res Commun 46:1493-8
year: 1972

UniProt:Q9GZ01
type: ProteinReference
xref: UnificationXref5241
organism: BioSource1

SequenceSite190
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite191
type: SequenceSite
position status: EQUAL
sequence position: 1480

SequenceSite192
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite193
type: SequenceSite
position status: EQUAL
sequence position: 1480

http://identifiers.org/pubmed/18690016
type: PublicationXref
id: 18690016
author: Schnetkamp, PP
author: Altimimi, HF
db: Pubmed
title: Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles
source: Channels (Austin) 1:62-9
year: 2007

SequenceSite194
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite195
type: SequenceSite
position status: EQUAL
sequence position: 1480

http://identifiers.org/pubmed/12473340
type: PublicationXref
id: 12473340
author: Dyson, NJ
author: Stevaux, O
db: Pubmed
title: A revised picture of the E2F transcriptional network and RB function.
source: Curr Opin Cell Biol 14:684-91
year: 2002

SequenceSite186
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite185
type: SequenceSite
position status: EQUAL
sequence position: 509

UniProt:E5F2V9
type: ProteinReference
xref: UnificationXref2769
organism: BioSource1

SequenceSite188
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite187
type: SequenceSite
position status: EQUAL
sequence position: 509

SequenceSite189
type: SequenceSite
position status: EQUAL
sequence position: 1480

PublicationXref466
type: PublicationXref
id: 0716720094
author: Stryer, L
db: ISBN
title: 21: Oxidative Phosphorylation
source: Biochemistry, 4th ed (Book): 548-549
year: 1995

SequenceSite180
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite183
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite184
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite181
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite182
type: SequenceSite
position status: EQUAL
sequence position: 1

Pb
type: SmallMoleculeReference
name: ChEBI:6397 Pb2+
name: Lead
name: Pb2+
xref: UnificationXref3404

SequenceSite177
type: SequenceSite
position status: EQUAL
sequence position: 1290

Resolution of D-loop structures
type: Pathway
data source: Provenance1
pathway component: REACT 99627.9
evidence: Evidence682
xref: UnificationXref5283
xref: UnificationXref5282
pathway order: PathwayStep662
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite176
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite175
type: SequenceSite
position status: EQUAL
sequence position: 414

SequenceSite174
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite179
type: SequenceSite
position status: EQUAL
sequence position: 465

SequenceSite178
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite171
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite170
type: SequenceSite
position status: EQUAL
sequence position: 1437

http://identifiers.org/pubmed/1904318
type: PublicationXref
id: 1904318
author: Knopf, JL
author: Milona, N
author: Sultzman, LA
author: Lin, AY
author: Ramesha, CS
author: Lin, LL
author: Kriz, RW
author: Clark, JD
db: Pubmed
title: A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP
source: Cell 65:1043-51
year: 1991

SequenceSite173
type: SequenceSite
position status: EQUAL
sequence position: 132

SequenceSite172
type: SequenceSite
position status: EQUAL
sequence position: 393

SequenceSite167
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite168
type: SequenceSite
position status: EQUAL
sequence position: 1437

http://identifiers.org/pubmed/17916383
type: PublicationXref
id: 17916383
author: Turunen, M
author: Swiezewska, E
author: Chojnacki, T
author: Dallner, G
author: Tekle, M
db: Pubmed
title: Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells
source: J Biochem Biophys Methods 70:909-17
year: 2008

SequenceSite169
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9153422
type: PublicationXref
id: 9153422
author: Batelier, G
author: Soulié, S
author: Melki, R
author: Williams RC, Jr
db: Pubmed
title: Cytoplasmic chaperonin containing TCP-1: structural and functional characterization
source: Biochemistry 36:5817-26
year: 1997

SequenceSite163
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite164
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite165
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite166
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite162
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite161
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite160
type: SequenceSite
position status: EQUAL
sequence position: 1437

http://identifiers.org/pubmed/8514871
type: PublicationXref
id: 8514871
author: Stead, RH
author: Hayward, CP
author: Warkentin, TE
author: Podor, TJ
author: Horsewood, P
author: Kelton, JG
author: Bainton, DF
author: Smith, JW
db: Pubmed
title: Multimerin is found in the alpha-granules of resting platelets and is synthesized by a megakaryocytic cell line
source: J Clin Invest 91:2630-9
year: 1993

http://identifiers.org/pubmed/5411545
type: PublicationXref
id: 5411545
author: Coniglio, JG
author: Bridges, RB
db: Pubmed
title: The biosynthesis of delta-9,12,15,18-tetracosatetraenoic and of delta-6,9,12,15,18-tetracosapentaenoic acids by rat testes
source: J Biol Chem 245:46-9
year: 1970

SequenceSite158
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite159
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite156
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite157
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite154
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite155
type: SequenceSite
position status: EQUAL
sequence position: 1

Protein folding
type: Pathway
data source: Provenance1
pathway component: Chaperonin-mediated protein folding
evidence: Evidence500
xref: UnificationXref4120
xref: RelationshipXref487
xref: UnificationXref4119
pathway order: PathwayStep486
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite152
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite153
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite151
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite150
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite149
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite141
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite142
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite143
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/14521909
type: PublicationXref
id: 14521909
author: Torii, H
author: Michibata, H
author: Chiba, H
author: Imai, Y
author: Seishima, M
author: Wakimoto, K
author: Okubo, K
author: Mitsui, H
author: Kawasaki, S
db: Pubmed
title: A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice
source: Biochem Biophys Res Commun 310:296-302
year: 2003

SequenceSite144
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite145
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite146
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite147
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite148
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite140
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite138
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite139
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite132
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite133
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite130
type: SequenceSite
position status: EQUAL
sequence position: 1437

http://identifiers.org/pubmed/1918382
type: PublicationXref
id: 1918382
author: Verma, US
author: Kusari, J
author: Olefsky, JM
author: Buse, JB
author: Henry, RR
db: Pubmed
title: Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus
source: J Clin Invest 88:1323-30
year: 1991

SequenceSite131
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite136
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite137
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite134
type: SequenceSite
position status: EQUAL
sequence position: 1437

SequenceSite135
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1708
type: UnificationXref
id: CHEBI:63821
db: ChEBI

UnificationXref1709
type: UnificationXref
id: 548816
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=548816

Metabolism of RNA
type: Pathway
data source: Provenance1
pathway component: REACT 31547.10
evidence: Evidence126
xref: UnificationXref1241
xref: UnificationXref1242
xref: RelationshipXref84
pathway order: PathwayStep122
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1704
type: UnificationXref
id: REACT_22855
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22855.1

UnificationXref1705
type: UnificationXref
id: 3656094
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656094

UnificationXref1706
type: UnificationXref
id: 3656096
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656096

http://identifiers.org/pubmed/7902568
type: PublicationXref
id: 7902568
author: Hopkinson, DA
author: March, RE
author: Whitehouse, DB
author: Edwards, YH
author: Ives, JH
author: Lovegrove, JU
author: Hollyoake, M
author: Putt, W
db: Pubmed
title: The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination
source: Proc Natl Acad Sci U S A 90:10730-3
year: 1993

UnificationXref1707
type: UnificationXref
id: REACT_132382
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132382.5

UnificationXref1700
type: UnificationXref
id: 548808
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=548808

UnificationXref1701
type: UnificationXref
id: REACT_23048
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23048.1

UnificationXref1702
type: UnificationXref
id: CHEBI:52977
db: ChEBI

UnificationXref1703
type: UnificationXref
id: 548797
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=548797

UnificationXref1710
type: UnificationXref
id: REACT_22500
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22500.1

UniProt:O97071
type: ProteinReference
xref: UnificationXref2399
organism: BioSource1

http://identifiers.org/pubmed/9177788
type: PublicationXref
id: 9177788
author: Reiter, L T
author: Lupski, J R
author: Murakami, T
db: Pubmed
title: Genomic structure and expression of the human heme A:farnesyltransferase (COX10) gene
source: Genomics 42:161-4
year: 1997

cobalamin(III)
type: SmallMoleculeReference
name: cob(III)alamin [ChEBI:28911]
name: alpha-(5,6-dimethylbenzimidazolyl)cobamide
name: Cobalamin (III)
name: cobalamin(1+)
name: cob(III)alamin
name: Cbl
xref: UnificationXref3113

UniProt:Q9Y010
type: ProteinReference
xref: UnificationXref4468
organism: BioSource1

G1/S-Specific Transcription
type: Pathway
data source: Provenance1
pathway component: Activation of E2F target genes at G1/S
evidence: Evidence577
xref: UnificationXref4767
xref: RelationshipXref539
xref: UnificationXref4768
pathway order: PathwayStep560
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/16154905
type: PublicationXref
id: 16154905
author: Manolescu, A
author: Joost, HG
author: Zahn, C
author: Schmidt, S
author: Cheeseman, CI
author: Scheepers, A
author: Bell, A
author: Schürmann, A
db: Pubmed
title: Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue
source: Mol Membr Biol 22:339-51
year: 2005

http://identifiers.org/pubmed/20185591
type: PublicationXref
id: 20185591
author: Green, Ralph
db: Pubmed
title: Ins and outs of cellular cobalamin transport
source: Blood 115:1476-7
year: 2010

UnificationXref1722
type: UnificationXref
id: REACT_128919
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128919.5

http://identifiers.org/pubmed/8672512
type: PublicationXref
id: 8672512
author: Horiuchi, S
author: Sano, H
author: Yoshida, M
author: Jinnouchi, Y
author: Higashi, T
author: Ikeda, K
author: Araki, T
author: Ueda, S
db: Pubmed
title: N (epsilon)-(carboxymethyl)lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of the Maillard reaction
source: Biochemistry 35:8075-83
year: 1996

UnificationXref1723
type: UnificationXref
id: CHEBI:50570
db: ChEBI

UnificationXref1724
type: UnificationXref
id: 548809
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=548809

UnificationXref1725
type: UnificationXref
id: REACT_22862
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22862.1

UnificationXref1726
type: UnificationXref
id: CHEBI:15541
db: ChEBI

UnificationXref1727
type: UnificationXref
id: 428139
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428139

UnificationXref1728
type: UnificationXref
id: REACT_20205
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20205.3

UnificationXref1729
type: UnificationXref
id: Q8II05
db: UniProt

UnificationXref1730
type: UnificationXref
id: 3656100
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656100

UnificationXref1732
type: UnificationXref
id: REACT_147128
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147128.5

UnificationXref1731
type: UnificationXref
id: 3656102
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656102

http://identifiers.org/pubmed/20576942
type: PublicationXref
id: 20576942
author: Kühl, Michael
author: Rao, Tata Purushothama
db: Pubmed
title: An updated overview on Wnt signaling pathways: a prelude for more
source: Circ. Res. 106:1798-806
year: 2010

Latent infection of Homo sapiens with Mycobacterium tuberculosis
type: Pathway
data source: Provenance1
pathway component: Phagosomal maturation (early endosomal stage)
evidence: Evidence4
xref: UnificationXref101
xref: UnificationXref102
xref: RelationshipXref7
pathway order: PathwayStep3
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1719
type: UnificationXref
id: REACT_22766
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22766.1

NH4+
type: SmallMoleculeReference
name: NH4+ [ChEBI:28938]
xref: UnificationXref2600

UnificationXref1713
type: UnificationXref
id: REACT_131648
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131648.5

UnificationXref1714
type: UnificationXref
id: CHEBI:15527
db: ChEBI

UnificationXref1711
type: UnificationXref
id: 3656082
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656082

UnificationXref1712
type: UnificationXref
id: 3656084
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656084

UnificationXref1717
type: UnificationXref
id: CHEBI:52328
db: ChEBI

UnificationXref1718
type: UnificationXref
id: 548829
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=548829

UnificationXref1715
type: UnificationXref
id: 548794
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=548794

UnificationXref1716
type: UnificationXref
id: REACT_22685
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22685.1

UnificationXref1721
type: UnificationXref
id: 3656093
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656093

UnificationXref1720
type: UnificationXref
id: 3656091
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3656091

http://identifiers.org/pubmed/16380219
type: PublicationXref
id: 16380219
author: Dean, NM
author: Koo, S
author: Kang, X
author: Kim, Y
author: White, N
author: Marcusson, EG
author: Perera, RJ
db: Pubmed
title: Identification of novel PPARgamma target genes in primary human adipocytes
source: Gene 369:90-9
year: 2006

http://identifiers.org/pubmed/10867024
type: PublicationXref
id: 10867024
author: Carraway KL, 3rd
author: Lai, C
author: Diamonti, AJ
author: Cantley, LC
author: Riese DJ, 2nd
author: Sweeney, C
db: Pubmed
title: Ligand discrimination in signaling through an ErbB4 receptor homodimer
source: J Biol Chem 275:19803-7
year: 2000

http://identifiers.org/pubmed/11175906
type: PublicationXref
id: 11175906
author: Burden, A
author: Wu, CK
author: Wang, BC
author: Dailey, HA
author: Rose, JP
author: Sellers, VM
db: Pubmed
title: The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis.
source: Nat Struct Biol 8:156-60
year: 2001

2,4-Dinitro-1-chlorobenzene
type: SmallMoleculeReference
name: 1-chloro-2,4-dinitrobenzene [ChEBI:34718]
name: DNCB
name: 1-Chloro-2,4-dinitrobenzol
name: 1-chloro-2,4-dinitrobenzene
name: Dncb
name: 6-Chloro-1,3-dinitrobenzene
name: Dinitrochlorobenzene
name: 1,3-Dinitro-4-chlorobenzene
name: Chlorodinitrobenzene
name: 2,4-Dinitrophenyl chloride
name: Cdnb
name: 4-Chloro-1,3-dinitrobenzene
name: 2,4-Dinitrochlorobenzene
xref: UnificationXref3555

http://identifiers.org/pubmed/9278091
type: PublicationXref
id: 9278091
author: Hildebrandt, JD
db: Pubmed
title: Role of subunit diversity in signaling by heterotrimeric G proteins
source: Biochem Pharmacol 54:325-39
year: 1997

http://identifiers.org/pubmed/10745006
type: PublicationXref
id: 10745006
author: Chuang, JL
author: Turley, S
author: Chuang, DT
author: Aevarsson, A
author: Wynn, RM
author: Hol, WG
db: Pubmed
title: Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease.
source: Structure Fold Des 8:277-91
year: 2000

http://identifiers.org/pubmed/10959839
type: PublicationXref
id: 10959839
author: Tomkinson, AE
author: McKenna, AE
author: Matsumoto, Y
author: Motycka, TA
author: Levin, DS
db: Pubmed
title: Interaction between PCNA and DNA ligase I is critical for joining of Okazaki fragments and long-patch base-excision repair.
source: Curr Biol 10:919-22
year: 2000

http://identifiers.org/pubmed/15845646
type: PublicationXref
id: 15845646
author: Desjardins, M
author: Bergeron, JJ
author: Gagnon, E
db: Pubmed
title: ER-mediated phagocytosis: myth or reality?
source: J Leukoc Biol 77:843-5
year: 2005

http://identifiers.org/pubmed/18760361
type: PublicationXref
id: 18760361
author: Maness, PF
author: Schmid, RS
db: Pubmed
title: L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth
source: Curr Opin Neurobiol 18:245-50
year: 2008

Adaptive Immune System
type: Pathway
data source: Provenance1
pathway component: TCR signaling
pathway component: REACT 132793.5
pathway component: REACT 147351.5
evidence: Evidence778
xref: UnificationXref5852
xref: UnificationXref5853
pathway order: PathwayStep741
pathway order: PathwayStep752
pathway order: PathwayStep743
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/15189140
type: PublicationXref
id: 15189140
author: de Lange, T
author: Smogorzewska, A
db: Pubmed
title: Regulation of telomerase by telomeric proteins
source: Annu Rev Biochem 73:177-208
year: 2004

http://identifiers.org/pubmed/9536209
type: PublicationXref
id: 9536209
author: Clarke, D
author: Cunningham, SK
author: Fearon, U
author: McKenna, TJ
db: Pubmed
title: A critical review of the origin and control of adrenal androgens
source: Baillieres Clin Obstet Gynaecol 11:229-48
year: 1997

http://identifiers.org/pubmed/8562305
type: PublicationXref
id: 8562305
author: Degerman, E
author: Belfrage, P
author: Manganiello, VC
author: Taira, M
db: Pubmed
title: Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family)
source: Cell Signal 7:445-55
year: 1995

http://identifiers.org/pubmed/15189156
type: PublicationXref
id: 15189156
author: Lorsch, JR
author: Kapp, LD
db: Pubmed
title: The molecular mechanics of eukaryotic translation
source: Annu Rev Biochem 73:657-704
year: 2004

http://identifiers.org/pubmed/15711010
type: PublicationXref
id: 15711010
author: Rémigy, H
author: Zaric, B
author: Engel, A
author: Winkler, FK
author: Ballmer-Hofer, K
author: Kambach, C
author: Chami, M
db: Pubmed
title: Reconstitution of two recombinant LSm protein complexes reveals aspects of their architecture, assembly, and function
source: J Biol Chem 280:16066-75
year: 2005

CHEBI:63539 [ChEBI:63539]
type: SmallMoleculeReference
name: CHEBI:63539
xref: UnificationXref2146

SequenceSite919
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite918
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite917
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite916
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite914
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite915
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite912
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite913
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite910
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite911
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/20417083
type: PublicationXref
id: 20417083
author: Bogan, JS
author: Kandror, KV
db: Pubmed
title: Biogenesis and regulation of insulin-responsive vesicles containing GLUT4
source: Curr Opin Cell Biol 22:506-12
year: 2010

http://identifiers.org/pubmed/20060739
type: PublicationXref
id: 20060739
author: Sheftel, Alex
author: Stehling, Oliver
author: Lill, R
db: Pubmed
title: Iron-sulfur proteins in health and disease
source: Trends Endocrinol. Metab. 21:302-14
year: 2010

CHEBI:63548 [ChEBI:63548]
type: SmallMoleculeReference
name: CHEBI:63548
xref: UnificationXref2177

CHEBI:63545 [ChEBI:63545]
type: SmallMoleculeReference
name: CHEBI:63545
xref: UnificationXref2130

CHEBI:63544
type: SmallMoleculeReference
name: CHEBI:63544 [ChEBI:63544]
xref: UnificationXref2172

CHEBI:63543
type: SmallMoleculeReference
name: CHEBI:63543 [ChEBI:63543]
xref: UnificationXref2155

CHEBI:63542 [ChEBI:63542]
type: SmallMoleculeReference
name: CHEBI:63542
xref: UnificationXref2133

SequenceSite928
type: SequenceSite
position status: EQUAL
sequence position: 299

CHEBI:63541
type: SmallMoleculeReference
name: CHEBI:63541 [ChEBI:63541]
xref: UnificationXref2149

SequenceSite927
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite929
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite923
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite924
type: SequenceSite
position status: EQUAL
sequence position: 296

SequenceSite925
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite926
type: SequenceSite
position status: EQUAL
sequence position: 314

SequenceSite920
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite921
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite922
type: SequenceSite
position status: EQUAL
sequence position: 279

SUMOylation
type: Pathway
data source: Provenance1
pathway component: Processing and Activation of SUMO
evidence: Evidence762
xref: RelationshipXref630
xref: UnificationXref5784
xref: UnificationXref5783
pathway order: PathwayStep737
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11435397
type: PublicationXref
id: 11435397
author: Allikmets, R
author: Dean, M
author: Rzhetsky, A
db: Pubmed
title: The human ATP-binding cassette (ABC) transporter superfamily
source: Genome Res 11:1156-66
year: 2001

http://identifiers.org/pubmed/16098809
type: PublicationXref
id: 16098809
author: Simmonds, HA
author: Zameitat, E
author: Fairbanks, LD
author: Marinaki, AM
author: Loffler, M
db: Pubmed
title: Pyrimidine pathways in health and disease
source: Trends Mol Med 11:430-7
year: 2005

SequenceSite906
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite905
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite908
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite907
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/183599
type: PublicationXref
id: 183599
author: Hers, HG
db: Pubmed
title: The control of glycogen metabolism in the liver
source: Annu Rev Biochem 45:167-89
year: 1976

SequenceSite909
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite900
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite901
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite902
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite903
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite904
type: SequenceSite
position status: EQUAL
sequence position: 711

http://identifiers.org/pubmed/12440953
type: PublicationXref
id: 12440953
author: Kruys, V
author: Huez, G
author: Gueydan, C
author: Zhang, T
db: Pubmed
title: AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors
source: Biochem Soc Trans 30:952-8
year: 2002

Hypusine synthesis from eIF5A-lysine
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction274
pathway component: BiochemicalReaction275
pathway component: BiochemicalReaction273
evidence: Evidence504
xref: UnificationXref4166
xref: RelationshipXref492
xref: UnificationXref4167
pathway order: PathwayStep490
pathway order: PathwayStep489
pathway order: PathwayStep488
display name: Hypusinylation
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

PublicationXref99
type: PublicationXref
id: 1416029990
author: Rapini, RP
author: Bolognia, JL
author: Jorizzo, JL
db: ISBN
title: Dermatology: 2-Volume Set
source: Dermatology: 2-Volume Set (Book)
year: 2007

Deamido-NAD+
type: SmallMoleculeReference
name: Deamino-NAD+
name: Deamino-NAD+ [ChEBI:4340]
xref: UnificationXref3125

ChEBI:18303 phosphatidyl-L-serine
type: SmallMoleculeReference
name: phosphatidyl-L-serine
xref: UnificationXref801

http://identifiers.org/pubmed/10744726
type: PublicationXref
id: 10744726
author: Corfas, G
author: Buxbaum, JD
author: Rio, C
author: Peschon, JJ
db: Pubmed
title: Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4
source: J Biol Chem 275:10379-87
year: 2000

http://identifiers.org/pubmed/10601273
type: PublicationXref
id: 10601273
author: Grippo, JF
author: Shiota, C
author: Coffey, J
author: Magnuson, MA
author: Grimsby, J
db: Pubmed
title: Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase
source: J Biol Chem 274:37125-30
year: 1999

PublicationXref92
type: PublicationXref
id: 0079130356
author: Suzuki, Y
author: Oshima, A
author: Nanba, E
db: ISBN
title: Beta-galactosidase deficiency (beta-galactosidosis): GM1 gangliosidosis and Morquio B disease
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 3775-3809
year: 2001

http://identifiers.org/pubmed/16213220
type: PublicationXref
id: 16213220
author: van der Wel, N
author: Peters, PJ
author: Houben, D
author: Shaw, J
author: Grinstein, S
author: de Chastellier, C
author: Paroutis, P
author: Harrison, RE
author: Moore, HP
author: Pypaert, M
author: Jiang, A
author: Trombetta, S
author: Chow, A
author: Terebiznik, M
author: Touret, N
author: Yip, C
author: Mellman, I
db: Pubmed
title: Quantitative and dynamic assessment of the contribution of the ER to phagosome formation
source: Cell 123:157-70
year: 2005

http://identifiers.org/pubmed/14624363
type: PublicationXref
id: 14624363
author: Bruford, EA
author: Hediger, MA
author: Rolfs, A
author: Romero, MF
author: Takanaga, H
author: Peng, JB
db: Pubmed
title: The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction
source: Pflugers Arch 447:465-8
year: 2004

Amino acid synthesis and interconversion (transamination)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction207
pathway component: BiochemicalReaction206
pathway component: BiochemicalReaction208
pathway component: BiochemicalReaction209
evidence: Evidence384
xref: UnificationXref3238
xref: RelationshipXref404
xref: UnificationXref3239
pathway order: PathwayStep375
pathway order: PathwayStep376
pathway order: PathwayStep377
pathway order: PathwayStep378
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10202136
type: PublicationXref
id: 10202136
author: Bockaert, J
author: Pin, JP
db: Pubmed
title: Molecular tinkering of G protein-coupled receptors: an evolutionary success
source: EMBO J 18:1723-9
year: 1999

WNT ligand biogenesis and trafficking
type: Pathway
data source: Provenance1
pathway component: N-linked glycosylation of WNTs
pathway component: WNT ligands traffic to the Golgi
evidence: Evidence845
xref: UnificationXref6065
xref: UnificationXref6064
pathway order: PathwayStep817
pathway order: PathwayStep818
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

N,N'-Diacetylchitobiosyldiphosphodolichol [ChEBI:7069]
type: SmallMoleculeReference
name: N,N'-Diacetylchitobiosyldiphosphodolichol
name: Chitobiosyldiphosphodolichol
xref: UnificationXref4295

SequenceSite2191
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2190
type: SequenceSite
position status: EQUAL
sequence position: 523

SequenceSite2193
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2192
type: SequenceSite
position status: EQUAL
sequence position: 775

SequenceSite2195
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2194
type: SequenceSite
position status: EQUAL
sequence position: 739

SequenceSite2197
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite2196
type: SequenceSite
position status: EQUAL
sequence position: 597

SequenceSite2199
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite2198
type: SequenceSite
position status: EQUAL
sequence position: 593

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
type: SmallMoleculeReference
name: ChEBI:18348 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
name: PIP2
xref: UnificationXref107

http://identifiers.org/pubmed/11015619
type: PublicationXref
id: 11015619
author: Rusnak, F
author: Mertz, P
db: Pubmed
title: Calcineurin: form and function
source: Physiol. Rev. 80:1483-521
year: 2000

http://identifiers.org/pubmed/19234479
type: PublicationXref
id: 19234479
author: Johnson, E
author: Lewinson, O
author: Rees, DC
db: Pubmed
title: ABC transporters: the power to change
source: Nat Rev Mol Cell Biol 10:218-27
year: 2009

http://identifiers.org/pubmed/9793760
type: PublicationXref
id: 9793760
author: Hamel, FG
author: Duckworth, WC
author: Bennett, RG
db: Pubmed
title: Insulin degradation: progress and potential.
source: Endocr Rev 19:608-24
year: 1998

8,11,14-Eicosatrienoyl-CoA
type: SmallMoleculeReference
name: 8,11,14-Icosatrienoyl-CoA
name: 8,11,14-Eicosatrienoyl-CoA [ChEBI:2300]
xref: UnificationXref2165

SequenceSite2182
type: SequenceSite
position status: EQUAL
sequence position: 528

SequenceSite2181
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2180
type: SequenceSite
position status: EQUAL
sequence position: 471

SequenceSite2186
type: SequenceSite
position status: EQUAL
sequence position: 1264

SequenceSite2185
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2184
type: SequenceSite
position status: EQUAL
sequence position: 1264

SequenceSite2183
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2189
type: SequenceSite
position status: EQUAL
sequence position: 42

SequenceSite2188
type: SequenceSite
position status: EQUAL
sequence position: 477

SequenceSite2187
type: SequenceSite
position status: EQUAL
sequence position: 15

Vitamin B1 (thiamin) metabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction191
evidence: Evidence355
xref: RelationshipXref363
xref: UnificationXref3045
xref: UnificationXref3046
pathway order: PathwayStep349
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Phosphate
type: SmallMoleculeReference
name: Orthophosphate
name: Orthophosphate [ChEBI:18367]
name: Inorganic Phosphate
xref: UnificationXref408

http://identifiers.org/pubmed/11257506
type: PublicationXref
id: 11257506
author: Gandour, RD
author: van der Leij, FR
author: Ramsay, RR
db: Pubmed
title: Molecular enzymology of carnitine transfer and transport
source: Biochim Biophys Acta 1546:21-43
year: 2001

Arg-tRNA(Arg)
type: SmallMoleculeReference
name: ChEBI:18366 Arg-tRNA(Arg)
xref: UnificationXref3918

6-(L-erythro-1,2-Dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
type: SmallMoleculeReference
name: 7,8-dihydroneopterin 3'-triphosphate [ChEBI:18372]
name: 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin
name: 6-(L-erythro-1,2-dihydroxy-3-triphosphooxypropyl)-7,8-dihydropterin
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
name: 7,8-dihydroneopterin 3'-triphosphate
xref: UnificationXref2394

http://identifiers.org/pubmed/11711427
type: PublicationXref
id: 11711427
author: Wang, X
db: Pubmed
title: The expanding role of mitochondria in apoptosis.
source: Genes Dev 15:2922-33
year: 2001

SequenceSite2264
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite2265
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2266
type: SequenceSite
position status: EQUAL
sequence position: 1325

Ammonia
type: SmallMoleculeReference
name: NH3 [ChEBI:16134]
name: NH3
xref: UnificationXref2590

SequenceSite2267
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2260
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite2261
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2262
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite2263
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1011
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1010
type: SequenceSite
position status: EQUAL
sequence position: 199

SequenceSite1013
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9278442
type: PublicationXref
id: 9278442
author: Shiba, K
author: Musier-Forsyth, K
author: Stello, T
author: Noda, T
author: Motegi, H
author: Schimmel, P
db: Pubmed
title: Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant
source: J Biol Chem 272:22809-16
year: 1997

SequenceSite1012
type: SequenceSite
position status: EQUAL
sequence position: 199

SequenceSite1018
type: SequenceSite
position status: EQUAL
sequence position: 332

SequenceSite1019
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1014
type: SequenceSite
position status: EQUAL
sequence position: 197

SequenceSite1015
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1016
type: SequenceSite
position status: EQUAL
sequence position: 197

SequenceSite1017
type: SequenceSite
position status: EQUAL
sequence position: 26

SequenceSite2269
type: SequenceSite
position status: EQUAL
sequence position: 1

Insulin receptor mediated signaling
type: Pathway
data source: Provenance1
pathway component: REACT 109486.9
pathway component: Insulin receptor signalling cascade
evidence: Evidence810
xref: RelationshipXref645
xref: UnificationXref5991
xref: UnificationXref5990
pathway order: PathwayStep781
pathway order: PathwayStep783
display name: Signaling by Insulin receptor
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite2268
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite2277
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2278
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite2275
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2276
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite2273
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2274
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite2271
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2272
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite1024
type: SequenceSite
position status: EQUAL
sequence position: 371

SequenceSite2270
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite1023
type: SequenceSite
position status: EQUAL
sequence position: 562

SequenceSite1022
type: SequenceSite
position status: EQUAL
sequence position: 1

Vitamin B1
type: SmallMoleculeReference
name: Antiberiberi factor
name: Thiamine
name: Thiamin [ChEBI:9530]
name: Thiamin
name: Aneurin
xref: UnificationXref3031

SequenceSite1021
type: SequenceSite
position status: EQUAL
sequence position: 379

SequenceSite1020
type: SequenceSite
position status: EQUAL
sequence position: 473

SequenceSite1029
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/12211029
type: PublicationXref
id: 12211029
author: Adman, Elinor T
author: Ibarra, Catherine
author: Atkins, William M
author: Stenkamp, Ronald E
author: Le Trong, Isolde
db: Pubmed
title: 1.3-A resolution structure of human glutathione S-transferase with S-hexyl glutathione bound reveals possible extended ligandin binding site
source: Proteins 48:618-27
year: 2002

SequenceSite1027
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1028
type: SequenceSite
position status: EQUAL
sequence position: 350

SequenceSite1025
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1026
type: SequenceSite
position status: EQUAL
sequence position: 552

http://identifiers.org/pubmed/8861954
type: PublicationXref
id: 8861954
author: Takeda, J
author: Kinoshita, T
author: Nakamura, N
author: Endo, Y
author: Maeda, Y
author: Inoue, N
author: Fujita, T
author: Ohishi, K
author: Takahashi, M
db: Pubmed
title: PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor
source: EMBO J 15:4254-61
year: 1996

SequenceSite2279
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2282
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite2283
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2284
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite2285
type: SequenceSite
position status: EQUAL
sequence position: 1

D-myo-Inositol 1,3,4,6-tetrakisphosphate
type: SmallMoleculeReference
name: Inositol 1,3,4,6-tetrakisphosphate
name: 1D-myo-Inositol 1,3,4,6-tetrakisphosphate [ChEBI:809]
name: 1D-myo-Inositol 1,3,4,6-tetrakisphosphate
xref: UnificationXref1492

SequenceSite2286
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite2287
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2288
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite2289
type: SequenceSite
position status: EQUAL
sequence position: 1

DNA Repair
type: Pathway
data source: Provenance1
pathway component: REACT 79999.9
pathway component: REACT 107274.9
pathway component: REACT 110113.9
evidence: Evidence699
xref: UnificationXref5344
xref: RelationshipXref579
xref: UnificationXref5343
pathway order: PathwayStep656
pathway order: PathwayStep679
pathway order: PathwayStep666
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite1031
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1030
type: SequenceSite
position status: EQUAL
sequence position: 350

SequenceSite1033
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1032
type: SequenceSite
position status: EQUAL
sequence position: 415

SequenceSite2280
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite1035
type: SequenceSite
position status: EQUAL
sequence position: 35

SequenceSite2281
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1034
type: SequenceSite
position status: EQUAL
sequence position: 399

SequenceSite1036
type: SequenceSite
position status: EQUAL
sequence position: 371

SequenceSite1037
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1038
type: SequenceSite
position status: EQUAL
sequence position: 369

SequenceSite1039
type: SequenceSite
position status: EQUAL
sequence position: 50

http://identifiers.org/pubmed/8752212
type: PublicationXref
id: 8752212
author: Hubbard, SR
author: Schlessinger, J
author: Mohammadi, M
db: Pubmed
title: Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism
source: Cell 86:577-87
year: 1996

UniProt:Q8I6U7
type: ProteinReference
xref: UnificationXref2439
organism: BioSource1

SequenceSite2295
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2296
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite2293
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2294
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite2299
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2297
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2298
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite1042
type: SequenceSite
position status: EQUAL
sequence position: 298

SequenceSite1041
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1040
type: SequenceSite
position status: EQUAL
sequence position: 327

SequenceSite2291
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1046
type: SequenceSite
position status: EQUAL
sequence position: 298

http://identifiers.org/pubmed/10336645
type: PublicationXref
id: 10336645
author: Kennedy, BP
author: Larsson Forsell, PK
author: Claesson, HE
db: Pubmed
title: The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene
source: Eur J Biochem 262:575-85
year: 1999

SequenceSite2292
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite1045
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1044
type: SequenceSite
position status: EQUAL
sequence position: 298

SequenceSite2290
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite1043
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite896
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite1049
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite895
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite894
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite1047
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite893
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1048
type: SequenceSite
position status: EQUAL
sequence position: 2458

SequenceSite892
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite891
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite890
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite899
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite898
type: SequenceSite
position status: EQUAL
sequence position: 711

SequenceSite897
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1054
type: SequenceSite
position status: EQUAL
sequence position: 250

SequenceSite1055
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1056
type: SequenceSite
position status: EQUAL
sequence position: 109

SequenceSite1057
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1050
type: SequenceSite
position status: EQUAL
sequence position: 2458

SequenceSite1051
type: SequenceSite
position status: EQUAL
sequence position: 1

2'-deoxyadenosine 5'-diphosphate
type: SmallMoleculeReference
name: 2'-deoxyadenosine 5'-diphosphate [ChEBI:16174]
name: dADP
xref: UnificationXref2875

SequenceSite1052
type: SequenceSite
position status: EQUAL
sequence position: 250

SequenceSite1053
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2221
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2220
type: SequenceSite
position status: EQUAL
sequence position: 875

SequenceSite2223
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2222
type: SequenceSite
position status: EQUAL
sequence position: 875

SequenceSite2228
type: SequenceSite
position status: EQUAL
sequence position: 941

SequenceSite2229
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2224
type: SequenceSite
position status: EQUAL
sequence position: 593

SequenceSite2225
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2226
type: SequenceSite
position status: EQUAL
sequence position: 593

SequenceSite2227
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1059
type: SequenceSite
position status: EQUAL
sequence position: 28

SequenceSite1058
type: SequenceSite
position status: EQUAL
sequence position: 127

SequenceSite1067
type: SequenceSite
position status: EQUAL
sequence position: 36

SequenceSite1068
type: SequenceSite
position status: EQUAL
sequence position: 509

SequenceSite1065
type: SequenceSite
position status: EQUAL
sequence position: 36

SequenceSite1066
type: SequenceSite
position status: EQUAL
sequence position: 509

SequenceSite1063
type: SequenceSite
position status: EQUAL
sequence position: 41

SequenceSite1064
type: SequenceSite
position status: EQUAL
sequence position: 1023

SequenceSite1061
type: SequenceSite
position status: EQUAL
sequence position: 44

SequenceSite1062
type: SequenceSite
position status: EQUAL
sequence position: 1086

SequenceSite2234
type: SequenceSite
position status: EQUAL
sequence position: 1141

SequenceSite2233
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1060
type: SequenceSite
position status: EQUAL
sequence position: 466

SequenceSite2232
type: SequenceSite
position status: EQUAL
sequence position: 1141

SequenceSite2231
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2230
type: SequenceSite
position status: EQUAL
sequence position: 941

SequenceSite2239
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2237
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2238
type: SequenceSite
position status: EQUAL
sequence position: 1112

SequenceSite2235
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2236
type: SequenceSite
position status: EQUAL
sequence position: 1141

http://identifiers.org/pubmed/8943342
type: PublicationXref
id: 8943342
author: Pestova, TV
author: Shatsky, IN
author: Hellen, CU
db: Pubmed
title: Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes.
source: Mol Cell Biol 16:6870-8
year: 1997

Transcription-coupled NER (TC-NER)
type: Pathway
data source: Provenance1
pathway component: REACT 105420.9
pathway component: BiochemicalReaction358
pathway component: Gap-filling DNA repair synthesis and ligation in TC-NER
evidence: Evidence697
xref: UnificationXref5339
xref: RelationshipXref577
xref: UnificationXref5340
pathway order: PathwayStep674
pathway order: PathwayStep676
pathway order: PathwayStep677
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/15231747
type: PublicationXref
id: 15231747
author: Lehner, B
author: Sanderson, CM
db: Pubmed
title: A protein interaction framework for human mRNA degradation
source: Genome Res 14:1315-23
year: 2004

SequenceSite1069
type: SequenceSite
position status: EQUAL
sequence position: 36

SequenceSite1072
type: SequenceSite
position status: EQUAL
sequence position: 68

SequenceSite1073
type: SequenceSite
position status: EQUAL
sequence position: 453

SequenceSite1074
type: SequenceSite
position status: EQUAL
sequence position: 53

SequenceSite1075
type: SequenceSite
position status: EQUAL
sequence position: 463

SequenceSite1076
type: SequenceSite
position status: EQUAL
sequence position: 28

SequenceSite1077
type: SequenceSite
position status: EQUAL
sequence position: 333

dGMP
type: SmallMoleculeReference
name: Deoxyguanylic acid
name: 2'-Deoxyguanosine 5'-phosphate
name: 2'-Deoxyguanosine 5'-monophosphate
name: dGMP [ChEBI:16192]
name: Deoxyguanosine monophosphate
xref: UnificationXref2789

SequenceSite1078
type: SequenceSite
position status: EQUAL
sequence position: 52

SequenceSite1079
type: SequenceSite
position status: EQUAL
sequence position: 463

SequenceSite2241
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2240
type: SequenceSite
position status: EQUAL
sequence position: 1112

SequenceSite2243
type: SequenceSite
position status: EQUAL
sequence position: 1

Urea [ChEBI:16199]
type: SmallMoleculeReference
name: Carbamide
name: Urea
xref: UnificationXref3334

SequenceSite2242
type: SequenceSite
position status: EQUAL
sequence position: 1112

http://identifiers.org/pubmed/17011499
type: PublicationXref
id: 17011499
author: Farmer, SR
db: Pubmed
title: Transcriptional control of adipocyte formation
source: Cell Metab 4:263-73
year: 2006

SequenceSite2245
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1070
type: SequenceSite
position status: EQUAL
sequence position: 509

SequenceSite2244
type: SequenceSite
position status: EQUAL
sequence position: 779

SequenceSite1071
type: SequenceSite
position status: EQUAL
sequence position: 110

SequenceSite2246
type: SequenceSite
position status: EQUAL
sequence position: 779

SequenceSite2247
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2248
type: SequenceSite
position status: EQUAL
sequence position: 934

SequenceSite2249
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1085
type: SequenceSite
position status: EQUAL
sequence position: 693

SequenceSite1086
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1083
type: SequenceSite
position status: EQUAL
sequence position: 514

SequenceSite1084
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/15257295
type: PublicationXref
id: 15257295
author: Gorospe, M
author: Lal, A
author: Martindale, JL
author: Yang, X
author: Kawai, T
author: Mazan-Mamczarz, K
db: Pubmed
title: Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs
source: EMBO J 23:3092-102
year: 2004

SequenceSite1089
type: SequenceSite
position status: EQUAL
sequence position: 457

SequenceSite1087
type: SequenceSite
position status: EQUAL
sequence position: 693

SequenceSite1088
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2252
type: SequenceSite
position status: EQUAL
sequence position: 648

SequenceSite2251
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2250
type: SequenceSite
position status: EQUAL
sequence position: 934

SequenceSite2256
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite1081
type: SequenceSite
position status: EQUAL
sequence position: 514

SequenceSite2255
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1082
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2254
type: SequenceSite
position status: EQUAL
sequence position: 1325

SequenceSite2253
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1080
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2259
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2257
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q8I6Z7
type: ProteinReference
xref: UnificationXref3742
organism: BioSource1

SequenceSite2258
type: SequenceSite
position status: EQUAL
sequence position: 1325

UniProt:Q8I6Z2
type: ProteinReference
xref: UnificationXref4612
organism: BioSource1

UniProt:Q8I6Z1
type: ProteinReference
xref: UnificationXref1668
organism: BioSource1

SequenceSite841
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite840
type: SequenceSite
position status: EQUAL
sequence position: 228

http://identifiers.org/pubmed/15234968
type: PublicationXref
id: 15234968
author: Tews, KN
author: Milavetz, BI
author: Lambeth, DO
author: Frohlich, D
author: Adkins, S
db: Pubmed
title: Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues
source: J Biol Chem 279:36621-4
year: 2004

SequenceSite845
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite844
type: SequenceSite
position status: EQUAL
sequence position: 1216

SequenceSite843
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q8I701
type: ProteinReference
xref: UnificationXref4161
organism: BioSource1

SequenceSite842
type: SequenceSite
position status: EQUAL
sequence position: 237

SequenceSite849
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite848
type: SequenceSite
position status: EQUAL
sequence position: 1234

SequenceSite847
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite846
type: SequenceSite
position status: EQUAL
sequence position: 1185

http://identifiers.org/pubmed/10224048
type: PublicationXref
id: 10224048
author: Guo, S
author: York, JD
author: Lemrow, SM
author: Stolz, LE
db: Pubmed
title: SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases
source: J Biol Chem 274:12990-5
year: 1999

SequenceSite830
type: SequenceSite
position status: EQUAL
sequence position: 612

SequenceSite832
type: SequenceSite
position status: EQUAL
sequence position: 515

SequenceSite831
type: SequenceSite
position status: EQUAL
sequence position: 2

UniProt:Q8I713
type: ProteinReference
xref: UnificationXref1104
organism: BioSource1

SequenceSite834
type: SequenceSite
position status: EQUAL
sequence position: 515

SequenceSite833
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite836
type: SequenceSite
position status: EQUAL
sequence position: 515

SequenceSite835
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite838
type: SequenceSite
position status: EQUAL
sequence position: 483

SequenceSite837
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite839
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q8I719
type: ProteinReference
xref: UnificationXref5567
organism: BioSource1

UniProt:Q8I716
type: ProteinReference
xref: UnificationXref5489
organism: BioSource1

http://identifiers.org/pubmed/11022047
type: PublicationXref
id: 11022047
author: Mak, EC
author: Ding, Jianping
author: Hamm, HE
author: Lopez, I
author: Lomasney, JW
db: Pubmed
title: A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway
source: J Biol Chem 276:2758-65
year: 2001

http://identifiers.org/pubmed/11022048
type: PublicationXref
id: 11022048
author: Shibatohge, M
author: Kataoka, T
author: Wu, D
author: Hu, CD
author: Masago, M
author: Song, C
author: Satoh, T
author: Kariyai, K
author: Yamawaki-Kataoka, Y
db: Pubmed
title: Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras
source: J Biol Chem 276:2752-7
year: 2001

http://identifiers.org/pubmed/8068008
type: PublicationXref
id: 8068008
author: Rödl, W
author: Rücknagel, KP
author: Werner, T
author: Bacher, A
author: Jaeger, E
author: Ziegler, I
author: Gütlich, M
db: Pubmed
title: Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme
source: Biochem J 302:215-21
year: 1994

Meiotic Recombination
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction236
evidence: Evidence431
xref: UnificationXref3648
xref: UnificationXref3649
pathway order: PathwayStep423
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/17392515
type: PublicationXref
id: 17392515
author: Doller, A
author: Müller, R
author: Eberhardt, W
author: Huwiler, A
author: Radeke, HH
author: Pfeilschifter, J
db: Pubmed
title: Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2
source: Mol Biol Cell 18:2137-48
year: 2007

http://identifiers.org/pubmed/8943353
type: PublicationXref
id: 8943353
author: Nevins, JR
author: Herendeen, DR
author: DeGregori, J
author: Leone, G
author: Ohtani, K
author: Kelly, TJ
db: Pubmed
title: Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor
source: Mol Cell Biol 16:6977-84
year: 1996

SequenceSite2205
type: SequenceSite
position status: EQUAL
sequence position: 17

Expression of KDELR3
type: TemplateReaction
data source: Provenance1
evidence: Evidence547
product: Homologues of KDELR3
xref: UnificationXref4448
xref: UnificationXref4449
participant: Homologues of KDELR3
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

SequenceSite827
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2204
type: SequenceSite
position status: EQUAL
sequence position: 360

Expression of KLHDC3
type: TemplateReaction
data source: Provenance1
evidence: Evidence548
product: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4453
xref: UnificationXref4452
participant: Note: the coordinates are copied over from Homo sapiens.
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

SequenceSite826
type: SequenceSite
position status: EQUAL
sequence position: 434

http://identifiers.org/pubmed/7935795
type: PublicationXref
id: 7935795
author: Fantl, WJ
author: Martin, JA
author: Williams, LT
author: Kikuchi, A
author: MacNicol, AM
author: Gross, RW
author: Muslin, AJ
db: Pubmed
title: Activation of Raf-1 by 14-3-3 proteins
source: Nature 371:612-4
year: 1994

SequenceSite2203
type: SequenceSite
position status: EQUAL
sequence position: 19

Expression of GSK3A
type: TemplateReaction
data source: Provenance1
evidence: Evidence545
product: O77344
xref: UnificationXref4437
xref: UnificationXref4438
participant: O77344
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

SequenceSite825
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2202
type: SequenceSite
position status: EQUAL
sequence position: 518

Expression of HYOU1
type: TemplateReaction
data source: Provenance1
evidence: Evidence546
product: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4442
xref: UnificationXref4441
participant: Note: the coordinates are copied over from Homo sapiens.
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

SequenceSite824
type: SequenceSite
position status: EQUAL
sequence position: 434

SequenceSite2209
type: SequenceSite
position status: EQUAL
sequence position: 27

Expression of DNAJB11
type: TemplateReaction
data source: Provenance1
evidence: Evidence543
product: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4431
xref: UnificationXref4432
participant: Note: the coordinates are copied over from Homo sapiens.
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

SequenceSite823
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/15761154
type: PublicationXref
id: 15761154
author: Pack, M
author: Chang, H
author: Delamarre, L
author: Trombetta, ES
author: Mellman, I
db: Pubmed
title: Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate
source: Science 307:1630-4
year: 2005

SequenceSite2208
type: SequenceSite
position status: EQUAL
sequence position: 1063

Expression of GFPT1
type: TemplateReaction
data source: Provenance1
evidence: Evidence544
product: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4433
xref: UnificationXref4434
participant: Note: the coordinates are copied over from Homo sapiens.
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

SequenceSite822
type: SequenceSite
position status: EQUAL
sequence position: 253

SequenceSite2207
type: SequenceSite
position status: EQUAL
sequence position: 27

Expression of ATP6VOD1
type: TemplateReaction
data source: Provenance1
evidence: Evidence541
product: Protein266
xref: UnificationXref4423
xref: UnificationXref4424
participant: Protein266
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

SequenceSite821
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2206
type: SequenceSite
position status: EQUAL
sequence position: 477

Expression of DDX11
type: TemplateReaction
data source: Provenance1
evidence: Evidence542
product: Q8IE72
xref: UnificationXref4427
xref: UnificationXref4428
participant: Q8IE72
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

SequenceSite820
type: SequenceSite
position status: EQUAL
sequence position: 254

SequenceSite2200
type: SequenceSite
position status: EQUAL
sequence position: 475

SequenceSite2201
type: SequenceSite
position status: EQUAL
sequence position: 35

Expression of SRPRB (SRP Receptor subunit beta)
type: TemplateReaction
data source: Provenance1
evidence: Evidence550
product: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4457
xref: UnificationXref4456
participant: Note: the coordinates are copied over from Homo sapiens.
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

SequenceSite828
type: SequenceSite
position status: EQUAL
sequence position: 314

Expression of SRPR (SRP Receptor subunit alpha)
type: TemplateReaction
data source: Provenance1
evidence: Evidence549
product: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4454
xref: UnificationXref4455
participant: Note: the coordinates are copied over from Homo sapiens.
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

SequenceSite829
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/18048764
type: PublicationXref
id: 18048764
author: Eizirik, DL
author: Cnop, M
author: Cardozo, AK
db: Pubmed
title: The role for endoplasmic reticulum stress in diabetes mellitus
source: Endocr Rev 29:42-61
year: 2008

Expression of SYVN1 (HRD1)
type: TemplateReaction
data source: Provenance1
evidence: Evidence551
product: E3 ubiquitin-protein ligase synoviolin
xref: UnificationXref4461
xref: UnificationXref4460
participant: E3 ubiquitin-protein ligase synoviolin
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

http://identifiers.org/pubmed/16543958
type: PublicationXref
id: 16543958
author: Hirsch, E
author: Rommel, C
author: Barberis, L
author: Montrucchio, G
author: Lembo, G
author: Costa, C
db: Pubmed
title: Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing
source: Thromb Haemost 95:29-35
year: 2006

SequenceSite2214
type: SequenceSite
position status: EQUAL
sequence position: 671

Pol II mediated transcription of microRNA genes
type: TemplateReaction
data source: Provenance1
evidence: Evidence723
product: PhysicalEntity150
xref: UnificationXref5560
xref: UnificationXref5559
participant: PhysicalEntity150
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

SequenceSite814
type: SequenceSite
position status: EQUAL
sequence position: 286

SequenceSite2213
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite813
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2216
type: SequenceSite
position status: EQUAL
sequence position: 762

SequenceSite816
type: SequenceSite
position status: EQUAL
sequence position: 286

SequenceSite2215
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite815
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2218
type: SequenceSite
position status: EQUAL
sequence position: 762

Expression of Sec31A
type: TemplateReaction
data source: Provenance1
evidence: Evidence552
product: Homologues of SEC31A
xref: UnificationXref4462
xref: UnificationXref4463
participant: Homologues of SEC31A
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

SequenceSite810
type: SequenceSite
position status: EQUAL
sequence position: 364

SequenceSite2217
type: SequenceSite
position status: EQUAL
sequence position: 1

Expression of TSPYL2
type: TemplateReaction
data source: Provenance1
evidence: Evidence553
product: Homologues of TSPYL2
xref: UnificationXref4474
xref: UnificationXref4473
participant: Homologues of TSPYL2
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

Expression of Asparagine Synthetase
type: TemplateReaction
data source: Provenance1
evidence: Evidence556
product: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref4479
xref: UnificationXref4480
participant: Note: the coordinates are copied over from Homo sapiens.
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

SequenceSite812
type: SequenceSite
position status: EQUAL
sequence position: 364

SequenceSite2219
type: SequenceSite
position status: EQUAL
sequence position: 1

Activation of E2F target genes at G1/S
type: TemplateReaction
data source: Provenance1
evidence: Evidence576
product: PhysicalEntity116
xref: UnificationXref4765
xref: UnificationXref4766
participant: PhysicalEntity116
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

SequenceSite811
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite817
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2210
type: SequenceSite
position status: EQUAL
sequence position: 1063

SequenceSite818
type: SequenceSite
position status: EQUAL
sequence position: 417

http://identifiers.org/pubmed/16914727
type: PublicationXref
id: 16914727
author: Caskey, LS
author: Cowan, KH
author: Sandahl, MA
author: Sgagias, MK
author: Sartor, CI
author: Earp HS, 3rd
author: Strunk, KE
author: Husted, C
author: McCall, W
author: Hunter, DM
author: Muraoka-Cook, RS
author: Rearick WA, Jr
db: Pubmed
title: Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1
source: Mol Cell Biol 26:6412-24
year: 2006

SequenceSite2211
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite819
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2212
type: SequenceSite
position status: EQUAL
sequence position: 671

SequenceSite888
type: SequenceSite
position status: EQUAL
sequence position: 2346

SequenceSite889
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q8I6S5
type: ProteinReference
xref: UnificationXref2464
organism: BioSource1

SequenceSite886
type: SequenceSite
position status: EQUAL
sequence position: 786

SequenceSite887
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite880
type: SequenceSite
position status: EQUAL
sequence position: 558

UniProt:F2X1X7
type: ProteinReference
xref: UnificationXref3836
organism: BioSource1

SequenceSite881
type: SequenceSite
position status: EQUAL
sequence position: 25

UniProt:Q7Z1F2
type: ProteinReference
xref: UnificationXref461
organism: BioSource1

SequenceSite884
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite885
type: SequenceSite
position status: EQUAL
sequence position: 2346

UniProt:F2X1X8
type: ProteinReference
xref: UnificationXref3841
organism: BioSource1

SequenceSite882
type: SequenceSite
position status: EQUAL
sequence position: 440

SequenceSite883
type: SequenceSite
position status: EQUAL
sequence position: 786

SequenceSite875
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite876
type: SequenceSite
position status: EQUAL
sequence position: 441

SequenceSite877
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite878
type: SequenceSite
position status: EQUAL
sequence position: 410

UniProt:Q8I6T2
type: ProteinReference
xref: UnificationXref357
organism: BioSource1

SequenceSite879
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q8I6T3
type: ProteinReference
xref: UnificationXref906
organism: BioSource1

http://identifiers.org/pubmed/12588972
type: PublicationXref
id: 12588972
author: Fox, PL
author: Sampath, P
author: Seshadri, V
author: Mazumder, B
db: Pubmed
title: Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region
source: Mol Cell Biol 23:1509-19
year: 2003

SequenceSite870
type: SequenceSite
position status: EQUAL
sequence position: 416

SequenceSite871
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite872
type: SequenceSite
position status: EQUAL
sequence position: 441

SequenceSite873
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite874
type: SequenceSite
position status: EQUAL
sequence position: 426

monomethylated residue
type: SequenceModificationVocabulary
xref: UnificationXref4620

http://identifiers.org/pubmed/16476485
type: PublicationXref
id: 16476485
author: Wahli, W
author: Gelman, L
author: Feige, JN
author: Desvergne, B
author: Michalik, L
db: Pubmed
title: From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
source: Prog Lipid Res 45:120-59
year: 2006

SequenceSite868
type: SequenceSite
position status: EQUAL
sequence position: 1573

SequenceSite869
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite866
type: SequenceSite
position status: EQUAL
sequence position: 1416

GRB2 events in EGFR signaling
type: Pathway
data source: Provenance1
pathway component: REACT 157443.3
evidence: Evidence17
xref: UnificationXref206
xref: UnificationXref205
pathway order: PathwayStep16
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite867
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite864
type: SequenceSite
position status: EQUAL
sequence position: 1693

SequenceSite865
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite862
type: SequenceSite
position status: EQUAL
sequence position: 1265

SequenceSite863
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite860
type: SequenceSite
position status: EQUAL
sequence position: 1290

SequenceSite861
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/14627618
type: PublicationXref
id: 14627618
author: Webb, RC
db: Pubmed
title: Smooth muscle contraction and relaxation
source: Adv Physiol Educ 27:201-6
year: 2003

cholest-5-en-3beta-ol
type: SmallMoleculeReference
name: cholesterol
name: cholesterol [ChEBI:16113]
xref: UnificationXref1595

Phosphatidyl-N-trimethylethanolamine
type: SmallMoleculeReference
name: Choline phosphatide
name: 1,2-diacyl-sn-glycero-3-phosphocholine
name: Phosphatidylcholine
name: Lecithin
name: lecithins
name: L-alpha-phosphatidylcholine
name: 1,2-diacyl-sn-glycero-3-phosphocholines
name: PC
name: (3-sn-phosphatidyl)choline
name: 1,2-diacyl-sn-glycero-3-phosphocholine [ChEBI:16110]
xref: UnificationXref1598

SequenceSite857
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite858
type: SequenceSite
position status: EQUAL
sequence position: 789

SequenceSite859
type: SequenceSite
position status: EQUAL
sequence position: 2

Dihydroxyacetone phosphate
type: SmallMoleculeReference
name: Glycerone phosphate
name: Dihydroxyacetone phosphate [ChEBI:16108]
xref: UnificationXref1262

SequenceSite853
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite854
type: SequenceSite
position status: EQUAL
sequence position: 756

SequenceSite855
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite856
type: SequenceSite
position status: EQUAL
sequence position: 2302

SequenceSite1004
type: SequenceSite
position status: EQUAL
sequence position: 1496

SequenceSite850
type: SequenceSite
position status: EQUAL
sequence position: 1175

SequenceSite1003
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite851
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1006
type: SequenceSite
position status: EQUAL
sequence position: 160

SequenceSite852
type: SequenceSite
position status: EQUAL
sequence position: 608

SequenceSite1005
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1008
type: SequenceSite
position status: EQUAL
sequence position: 160

SequenceSite1007
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1009
type: SequenceSite
position status: EQUAL
sequence position: 2

UniProt:Q7Z1F1
type: ProteinReference
xref: UnificationXref463
organism: BioSource1

SequenceSite1000
type: SequenceSite
position status: EQUAL
sequence position: 556

SequenceSite1001
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1002
type: SequenceSite
position status: EQUAL
sequence position: 806

http://identifiers.org/pubmed/8424766
type: PublicationXref
id: 8424766
author: Walker, TR
author: Watson, SP
db: Pubmed
title: Synergy between Ca2+ and protein kinase C is the major factor in determining the level of secretion from human platelets
source: Biochem J 289:277-82
year: 1993

http://identifiers.org/pubmed/17475546
type: PublicationXref
id: 17475546
author: Heikkinen, S
author: Argmann, CA
author: Auwerx, J
db: Pubmed
title: PPARgamma in human and mouse physiology
source: Biochim Biophys Acta 1771:999-1013
year: 2007

Zinc efflux and compartmentalization by the SLC30 family
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction27
pathway component: BiochemicalReaction29
pathway component: BiochemicalReaction28
evidence: Evidence89
xref: UnificationXref709
xref: UnificationXref710
pathway order: PathwayStep84
pathway order: PathwayStep86
pathway order: PathwayStep85
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/16828287
type: PublicationXref
id: 16828287
author: Robinson, FL
author: Dixon, JE
db: Pubmed
title: Myotubularin phosphatases: policing 3-phosphoinositides
source: Trends Cell Biol 16:403-12
year: 2006

http://identifiers.org/pubmed/6696436
type: PublicationXref
id: 6696436
author: Freemont, PS
author: Fothergill, LA
author: Dunbar, B
db: Pubmed
title: Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments
source: Arch Biochem Biophys 228:342-52
year: 1984

http://identifiers.org/pubmed/7593639
type: PublicationXref
id: 7593639
author: Huypens, P
author: Heimberg, H
author: Bouwens, L
author: Quartier, E
author: Schuit, F
author: Pipeleers, D
author: De Vos, A
db: Pubmed
title: Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression
source: J Clin Invest 96:2489-95
year: 1995

Generation of second messenger molecules
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction397
pathway component: BiochemicalReaction398
evidence: Evidence765
xref: UnificationXref5792
xref: UnificationXref5791
pathway order: PathwayStep739
pathway order: PathwayStep738
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/6975347
type: PublicationXref
id: 6975347
author: Robb, RJ
author: Smith, KA
author: Munck, A
db: Pubmed
title: T cell growth factor receptors. Quantitation, specificity, and biological relevance
source: J Exp Med 154:1455-74
year: 1981

Synthesis of PE
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction112
pathway component: BiochemicalReaction114
pathway component: BiochemicalReaction113
pathway component: BiochemicalReaction115
evidence: Evidence237
xref: UnificationXref1986
xref: UnificationXref1985
xref: RelationshipXref210
pathway order: PathwayStep228
pathway order: PathwayStep231
pathway order: PathwayStep230
pathway order: PathwayStep229
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/2780561
type: PublicationXref
id: 2780561
author: Moyzis, RK
author: Ratliff, RL
author: Meyne, J
db: Pubmed
title: Conservation of the human telomere sequence (TTAGGG)n among vertebrates
source: Proc Natl Acad Sci U S A 86:7049-53
year: 1989

Pyridoxal 5'-phosphate
type: SmallMoleculeReference
name: Pyridoxal 5-phosphate
name: Pyridoxal phosphate
name: Pyridoxal phosphate [ChEBI:18405]
xref: UnificationXref3191

http://identifiers.org/pubmed/10441588
type: PublicationXref
id: 10441588
author: Li, TK
author: Chen, CC
author: Wang, MF
author: Chen, YC
author: Chang, YC
author: Yin, SJ
author: Lu, RB
db: Pubmed
title: Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.
source: Am J Hum Genet 65:795-807
year: 1999

http://identifiers.org/pubmed/15548604
type: PublicationXref
id: 15548604
author: Scholler, C
author: Veiga-da-Cunha, M
author: Marquardt, T
author: Rzem, R
author: Van Schaftingen, E
author: Goffette, S
author: Noel, G
author: Vikkula, M
author: Nassogne, MC
author: Tabarki, B
db: Pubmed
title: A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduria
source: Proc Natl Acad Sci U S A 101:16849-54
year: 2004

Galactose catabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction58
evidence: Evidence152
xref: RelationshipXref107
xref: UnificationXref1375
xref: UnificationXref1374
pathway order: PathwayStep142
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Organic cation transport
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction30
evidence: Evidence93
xref: UnificationXref733
xref: UnificationXref734
pathway order: PathwayStep90
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/19247306
type: PublicationXref
id: 19247306
author: Beenken, A
author: Mohammadi, M
db: Pubmed
title: The FGF family: biology, pathophysiology and therapy
source: Nat Rev Drug Discov 8:235-53
year: 2009

http://identifiers.org/pubmed/17996737
type: PublicationXref
id: 17996737
author: Chacinska, A
author: Guiard, B
author: Milenkovic, D
author: Stojanovski, D
author: Müller, JM
author: Pfanner, N
db: Pubmed
title: The MIA system for protein import into the mitochondrial intermembrane space
source: Biochim Biophys Acta 1783:610-7
year: 2008

SequenceSite807
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite806
type: SequenceSite
position status: EQUAL
sequence position: 431

SequenceSite809
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite808
type: SequenceSite
position status: EQUAL
sequence position: 558

http://identifiers.org/pubmed/15660128
type: PublicationXref
id: 15660128
author: Lois, Luisa Maria
author: Lima, Christopher D
db: Pubmed
title: Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1
source: EMBO J. 24:439-51
year: 2005

SequenceSite802
type: SequenceSite
position status: EQUAL
sequence position: 1107

SequenceSite803
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/18721752
type: PublicationXref
id: 18721752
author: Lane, WS
author: Kaushansky, A
author: MacBeath, G
author: Rush, J
author: Budnik, BA
author: Gordus, A
db: Pubmed
title: System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties
source: Chem Biol 15:808-17
year: 2008

SequenceSite804
type: SequenceSite
position status: EQUAL
sequence position: 1129

SequenceSite805
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite800
type: SequenceSite
position status: EQUAL
sequence position: 1129

SequenceSite801
type: SequenceSite
position status: EQUAL
sequence position: 1089

http://identifiers.org/pubmed/18471901
type: PublicationXref
id: 18471901
author: Voets, T
author: Nilius, B
author: Talavera, K
db: Pubmed
title: Neuronal TRP channels: thermometers, pathfinders and life-savers
source: Trends Neurosci 31:287-95
year: 2008

Smooth Muscle Contraction
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction4
evidence: Evidence852
xref: RelationshipXref654
xref: UnificationXref6079
xref: UnificationXref6078
pathway order: PathwayStep6
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/20494131
type: PublicationXref
id: 20494131
author: Welin, M
author: Nordlund, P
db: Pubmed
title: Understanding specificity in metabolic pathways--structural biology of human nucleotide metabolism
source: Biochem Biophys Res Commun 396:157-63
year: 2010

http://identifiers.org/pubmed/8682206
type: PublicationXref
id: 8682206
author: Authier, F
author: Bergeron, JJ
author: Posner, BI
db: Pubmed
title: Endosomal proteolysis of internalized proteins.
source: FEBS Lett 389:55-60
year: 1996

UniProt:P27362
type: ProteinReference
xref: UnificationXref1292
organism: BioSource1

http://identifiers.org/pubmed/17567461
type: PublicationXref
id: 17567461
author: Lemasters, JJ
db: Pubmed
title: Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism
source: J Gastroenterol Hepatol 22:S31-7
year: 2007

NGF signalling via TRKA from the plasma membrane
type: Pathway
data source: Provenance1
pathway component: Signalling to ERKs
pathway component: REACT 114294.8
evidence: Evidence818
xref: UnificationXref6007
xref: UnificationXref6006
pathway order: PathwayStep790
pathway order: PathwayStep791
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/12765839
type: PublicationXref
id: 12765839
author: Stork, PJ
db: Pubmed
title: Does Rap1 deserve a bad Rap?
source: Trends Biochem Sci 28:267-75
year: 2003

http://identifiers.org/pubmed/3594573
type: PublicationXref
id: 3594573
author: Rothman, JE
author: Gleason, ML
author: Serafini, TA
author: Wieland, FT
db: Pubmed
title: The rate of bulk flow from the endoplasmic reticulum to the cell surface
source: Cell 50:289-300
year: 1987

http://identifiers.org/pubmed/19531029
type: PublicationXref
id: 19531029
author: Kawamukai, Makoto
db: Pubmed
title: Biosynthesis and bioproduction of coenzyme Q10 by yeasts and other organisms
source: Biotechnol. Appl. Biochem. 53:217-26
year: 2009

Mg++
type: SmallMoleculeReference
name: Magnesium [ChEBI:18420]
name: Mg2+
name: Magnesium
xref: UnificationXref141

SequenceSite1097
type: SequenceSite
position status: EQUAL
sequence position: 363

SequenceSite1096
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SequenceSite1095
type: SequenceSite
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SequenceSite1094
type: SequenceSite
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SequenceSite1099
type: SequenceSite
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sequence position: 363

SequenceSite1098
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1093
type: SequenceSite
position status: EQUAL
sequence position: 456

MLCL
type: SmallMoleculeReference
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name: Monolysocardiolipin
name: monolyso cardiolipin [ChEBI:60430]
name: monolysoDPG
name: monolyso cardiolipin
xref: UnificationXref2081

SequenceSite1092
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1091
type: SequenceSite
position status: EQUAL
sequence position: 457

SequenceSite1090
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q8MYK5
type: ProteinReference
xref: UnificationXref3407
organism: BioSource1

SequenceSite2099
type: SequenceSite
position status: EQUAL
sequence position: 734

http://identifiers.org/pubmed/10798271
type: PublicationXref
id: 10798271
author: Heindl, B
author: Zahler, S
author: Kupatt, C
author: Becker, BF
db: Pubmed
title: Endothelial function and hemostasis
source: Z Kardiol 89:160-7
year: 2000

SequenceSite2096
type: SequenceSite
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sequence position: 2

SequenceSite2095
type: SequenceSite
position status: EQUAL
sequence position: 904

SequenceSite2098
type: SequenceSite
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SequenceSite2097
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SequenceSite2092
type: SequenceSite
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SequenceSite2091
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SequenceSite2094
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SequenceSite2093
type: SequenceSite
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sequence position: 904

SequenceSite2090
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Chaperonin-mediated protein folding
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xref: RelationshipXref485
xref: UnificationXref4118
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comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite2089
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sequence position: 863

SequenceSite2088
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sequence position: 1

SequenceSite2087
type: SequenceSite
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SequenceSite2086
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SequenceSite2085
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SequenceSite2084
type: SequenceSite
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SequenceSite2083
type: SequenceSite
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http://identifiers.org/pubmed/10851172
type: PublicationXref
id: 10851172
author: Miller, FD
author: Kaplan, DR
db: Pubmed
title: Neurotrophin signal transduction in the nervous system
source: Curr Opin Neurobiol 10:381-91
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SequenceSite2082
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SequenceSite2081
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SequenceSite2080
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SequenceSite2074
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SequenceSite2073
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SequenceSite2076
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SequenceSite2075
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SequenceSite2078
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SequenceSite2077
type: SequenceSite
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SequenceSite2079
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SequenceSite2070
type: SequenceSite
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SequenceSite2072
type: SequenceSite
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SequenceSite2071
type: SequenceSite
position status: EQUAL
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SequenceSite2065
type: SequenceSite
position status: EQUAL
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SequenceSite2064
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SequenceSite2063
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SequenceSite2062
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SequenceSite2069
type: SequenceSite
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SequenceSite2068
type: SequenceSite
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SequenceSite2067
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SequenceSite2066
type: SequenceSite
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http://identifiers.org/pubmed/9054505
type: PublicationXref
id: 9054505
author: Makarov, VL
author: Hirose, Y
author: Langmore, JP
db: Pubmed
title: Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
source: Cell 88:657-66
year: 1997

SequenceSite2061
type: SequenceSite
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SequenceSite2060
type: SequenceSite
position status: EQUAL
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SequenceSite1150
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SequenceSite1152
type: SequenceSite
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SequenceSite1151
type: SequenceSite
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SequenceSite1154
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SequenceSite1153
type: SequenceSite
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SequenceSite1156
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SequenceSite2160
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SequenceSite1155
type: SequenceSite
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SequenceSite2161
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SequenceSite2162
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SequenceSite2163
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SequenceSite2164
type: SequenceSite
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SequenceSite2165
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SequenceSite2166
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SequenceSite2167
type: SequenceSite
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SequenceSite2168
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SequenceSite2169
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SequenceSite788
type: SequenceSite
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http://identifiers.org/pubmed/21755468
type: PublicationXref
id: 21755468
author: Ketting, RF
db: Pubmed
title: microRNA Biogenesis and Function : An overview
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SequenceSite787
type: SequenceSite
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SequenceSite789
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SequenceSite784
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SequenceSite1157
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SequenceSite783
type: SequenceSite
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SequenceSite1158
type: SequenceSite
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SequenceSite786
type: SequenceSite
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SequenceSite1159
type: SequenceSite
position status: EQUAL
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SequenceSite785
type: SequenceSite
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SequenceSite780
type: SequenceSite
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SequenceSite782
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SequenceSite781
type: SequenceSite
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SequenceSite1163
type: SequenceSite
position status: EQUAL
sequence position: 313

phosphorylated residue
type: SequenceModificationVocabulary
xref: UnificationXref3632

SequenceSite1162
type: SequenceSite
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http://identifiers.org/pubmed/7717389
type: PublicationXref
id: 7717389
author: Cox, TM
author: Ali, M
db: Pubmed
title: Diverse mutations in the aldolase B gene that underlie the prevalence of hereditary fructose intolerance
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SequenceSite1161
type: SequenceSite
position status: EQUAL
sequence position: 313

SequenceSite1160
type: SequenceSite
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SequenceSite2170
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SequenceSite1167
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SequenceSite2171
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SequenceSite1166
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SequenceSite1165
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http://identifiers.org/pubmed/12095677
type: PublicationXref
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author: Jackowski, S
author: Zhang, YM
author: Rock, CO
author: Karim, MA
db: Pubmed
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SequenceSite1164
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SequenceSite2174
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http://identifiers.org/pubmed/12853463
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author: Menichelli, E
author: Kuglstatter, A
author: Isel, C
author: Oubridge, C
author: Jovine, L
db: Pubmed
title: Structure, function and evolution of the signal recognition particle
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http://identifiers.org/pubmed/7689884
type: PublicationXref
id: 7689884
author: Kurl, RN
author: Verma, M
db: Pubmed
title: Human lung enolase: cloning and sequencing of cDNA and its inducibility with dexamethasone
source: Biochem Mol Biol Int 30:293-303
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SequenceSite2175
type: SequenceSite
position status: EQUAL
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SequenceSite2172
type: SequenceSite
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SequenceSite2173
type: SequenceSite
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SequenceSite2178
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SequenceSite2179
type: SequenceSite
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http://identifiers.org/pubmed/12686127
type: PublicationXref
id: 12686127
author: Hillary, RA
author: Pegg, AE
db: Pubmed
title: Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide
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SequenceSite2176
type: SequenceSite
position status: EQUAL
sequence position: 514

UDP-N-acetyl-D-glucosamine
type: SmallMoleculeReference
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xref: UnificationXref4254

SequenceSite2177
type: SequenceSite
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sequence position: 1

UniProt:Q8I5T4
type: ProteinReference
xref: UnificationXref4942
organism: BioSource1

UniProt:Q8I5T2
type: ProteinReference
xref: UnificationXref2226
organism: BioSource1

SequenceSite779
type: SequenceSite
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sequence position: 2

SequenceSite778
type: SequenceSite
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sequence position: 145

http://identifiers.org/pubmed/2684966
type: PublicationXref
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author: Kaji, A
author: Ichikawa, S
db: Pubmed
title: Molecular cloning and expression of ribosome releasing factor
source: J Biol Chem 264:20054-9
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SequenceSite777
type: SequenceSite
position status: EQUAL
sequence position: 2

UniProt:Q8I5T7
type: ProteinReference
xref: UnificationXref4957
organism: BioSource1

SequenceSite776
type: SequenceSite
position status: EQUAL
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SequenceSite775
type: SequenceSite
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sequence position: 2

SequenceSite774
type: SequenceSite
position status: EQUAL
sequence position: 214

SequenceSite773
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SequenceSite1168
type: SequenceSite
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SequenceSite772
type: SequenceSite
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SequenceSite1169
type: SequenceSite
position status: EQUAL
sequence position: 313

SequenceSite771
type: SequenceSite
position status: EQUAL
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SequenceSite770
type: SequenceSite
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sequence position: 248

SequenceSite1132
type: SequenceSite
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SequenceSite1131
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sequence position: 313

SequenceSite1134
type: SequenceSite
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SequenceSite1133
type: SequenceSite
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sequence position: 313

SequenceSite1130
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SequenceSite2143
type: SequenceSite
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SequenceSite2144
type: SequenceSite
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SequenceSite2145
type: SequenceSite
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SequenceSite2146
type: SequenceSite
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SequenceSite2140
type: SequenceSite
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SequenceSite2141
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SequenceSite2142
type: SequenceSite
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SequenceSite2148
type: SequenceSite
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sequence position: 1

SequenceSite2147
type: SequenceSite
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sequence position: 380

SequenceSite2149
type: SequenceSite
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SequenceSite1139
type: SequenceSite
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UniProt:Q8I5U0
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SequenceSite1135
type: SequenceSite
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sequence position: 313

SequenceSite1136
type: SequenceSite
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SequenceSite1137
type: SequenceSite
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SequenceSite1138
type: SequenceSite
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SequenceSite1145
type: SequenceSite
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sequence position: 313

SequenceSite1144
type: SequenceSite
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SequenceSite1143
type: SequenceSite
position status: EQUAL
sequence position: 313

SequenceSite1142
type: SequenceSite
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SequenceSite1141
type: SequenceSite
position status: EQUAL
sequence position: 313

H2O2
type: SmallMoleculeReference
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name: H2O2 [ChEBI:16240]
xref: UnificationXref3473

SequenceSite1140
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/7917292
type: PublicationXref
id: 7917292
author: Furness, J
author: Doherty, P
author: Walsh, FS
author: Williams, EJ
db: Pubmed
title: Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin
source: Neuron 13:583-94
year: 1994

SequenceSite2156
type: SequenceSite
position status: EQUAL
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SequenceSite2157
type: SequenceSite
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sequence position: 1

SequenceSite2154
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2155
type: SequenceSite
position status: EQUAL
sequence position: 297

SequenceSite2152
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2153
type: SequenceSite
position status: EQUAL
sequence position: 916

SequenceSite2150
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2151
type: SequenceSite
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sequence position: 339

Synthesis of IP2, IP, and Ins in the cytosol
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data source: Provenance1
pathway component: BiochemicalReaction84
pathway component: BiochemicalReaction83
evidence: Evidence183
xref: UnificationXref1592
xref: RelationshipXref122
xref: UnificationXref1591
pathway order: PathwayStep176
pathway order: PathwayStep177
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite799
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite798
type: SequenceSite
position status: EQUAL
sequence position: 411

UniProt:Q8I5V6
type: ProteinReference
xref: UnificationXref841
organism: BioSource1

UniProt:Q02602
type: ProteinReference
xref: UnificationXref1672
organism: BioSource1

UniProt:Q8I5V4
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xref: UnificationXref5584
organism: BioSource1

SequenceSite2159
type: SequenceSite
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sequence position: 2

SequenceSite2158
type: SequenceSite
position status: EQUAL
sequence position: 1970

SequenceSite793
type: SequenceSite
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UniProt:Q8I5V3
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organism: BioSource1

SequenceSite792
type: SequenceSite
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sequence position: 174

SequenceSite791
type: SequenceSite
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SequenceSite790
type: SequenceSite
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SequenceSite797
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SequenceSite1148
type: SequenceSite
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SequenceSite796
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sequence position: 411

SequenceSite1149
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position status: EQUAL
sequence position: 313

SequenceSite795
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SequenceSite1146
type: SequenceSite
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SequenceSite794
type: SequenceSite
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SequenceSite1147
type: SequenceSite
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sequence position: 313

SequenceSite2120
type: SequenceSite
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SequenceSite2122
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sequence position: 1

SequenceSite2121
type: SequenceSite
position status: EQUAL
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SequenceSite1190
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SequenceSite2124
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1191
type: SequenceSite
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sequence position: 591

http://identifiers.org/pubmed/11562789
type: PublicationXref
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author: Burnham, CE
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db: Pubmed
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SequenceSite2123
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position status: EQUAL
sequence position: 1148

SequenceSite1192
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sequence position: 1

SequenceSite1193
type: SequenceSite
position status: EQUAL
sequence position: 591

SequenceSite1194
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SequenceSite1195
type: SequenceSite
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sequence position: 591

SequenceSite1196
type: SequenceSite
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sequence position: 1

SequenceSite1197
type: SequenceSite
position status: EQUAL
sequence position: 586

SequenceSite1198
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1199
type: SequenceSite
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sequence position: 586

http://identifiers.org/pubmed/11313909
type: PublicationXref
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author: Wong, YH
author: Ho, MK
db: Pubmed
title: G(z) signaling: emerging divergence from G(i) signaling
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UniProt:Q8I5W2
type: ProteinReference
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SequenceSite2125
type: SequenceSite
position status: EQUAL
sequence position: 919

SequenceSite2126
type: SequenceSite
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SequenceSite2127
type: SequenceSite
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sequence position: 919

SequenceSite2128
type: SequenceSite
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SequenceSite2129
type: SequenceSite
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sequence position: 117

SequenceSite2131
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sequence position: 1087

SequenceSite2130
type: SequenceSite
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sequence position: 1

SequenceSite2135
type: SequenceSite
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sequence position: 298

SequenceSite2134
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sequence position: 1

SequenceSite2133
type: SequenceSite
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sequence position: 961

SequenceSite2132
type: SequenceSite
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sequence position: 1

UniProt:D5L5S7
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xref: UnificationXref276
organism: BioSource1

SequenceSite2138
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sequence position: 1

UniProt:Q8I5X8
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xref: UnificationXref3787
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SequenceSite2139
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Unfolded Protein Response
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xref: UnificationXref4486
xref: RelationshipXref530
xref: UnificationXref4485
pathway order: PathwayStep545
pathway order: PathwayStep542
pathway order: PathwayStep527
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite2136
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sequence position: 1

UniProt:D5L5S8
type: ProteinReference
xref: UnificationXref264
organism: BioSource1

SequenceSite2137
type: SequenceSite
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sequence position: 546

UniProt:D5L5S3
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SequenceSite2100
type: SequenceSite
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sequence position: 1

SequenceSite2102
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2101
type: SequenceSite
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sequence position: 734

SequenceSite1170
type: SequenceSite
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SequenceSite1175
type: SequenceSite
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sequence position: 313

SequenceSite1176
type: SequenceSite
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sequence position: 2

SequenceSite1177
type: SequenceSite
position status: EQUAL
sequence position: 313

SequenceSite1178
type: SequenceSite
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SequenceSite1171
type: SequenceSite
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sequence position: 313

SequenceSite1172
type: SequenceSite
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sequence position: 2

SequenceSite1173
type: SequenceSite
position status: EQUAL
sequence position: 313

SequenceSite1174
type: SequenceSite
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sequence position: 2

http://identifiers.org/pubmed/20385007
type: PublicationXref
id: 20385007
author: Turbeville, Sean
author: Harmatz, Paul
author: Nicely, Helen
author: Valayannopoulos, Vassili
db: Pubmed
title: Mucopolysaccharidosis VI
source: Orphanet J Rare Dis 5:5
year: 2010

UniProt:Q8I5Y3
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SequenceSite1179
type: SequenceSite
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sequence position: 313

SequenceSite2107
type: SequenceSite
position status: EQUAL
sequence position: 363

SequenceSite2108
type: SequenceSite
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sequence position: 1

SequenceSite2109
type: SequenceSite
position status: EQUAL
sequence position: 354

Activation of Chaperones by ATF6-alpha
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xref: RelationshipXref529
xref: UnificationXref4421
xref: UnificationXref4422
pathway order: PathwayStep526
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite2103
type: SequenceSite
position status: EQUAL
sequence position: 840

SequenceSite2104
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2105
type: SequenceSite
position status: EQUAL
sequence position: 363

http://identifiers.org/pubmed/18195086
type: PublicationXref
id: 18195086
author: Ashmore, J
db: Pubmed
title: Cochlear outer hair cell motility
source: Physiol Rev 88:173-210
year: 2008

SequenceSite2106
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2113
type: SequenceSite
position status: EQUAL
sequence position: 340

SequenceSite1180
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2112
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1181
type: SequenceSite
position status: EQUAL
sequence position: 313

SequenceSite2111
type: SequenceSite
position status: EQUAL
sequence position: 354

SequenceSite2110
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1188
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1189
type: SequenceSite
position status: EQUAL
sequence position: 212

SequenceSite1186
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite1187
type: SequenceSite
position status: EQUAL
sequence position: 196

2'-deoxyadenosine 5'-triphosphate
type: SmallMoleculeReference
name: Deoxyadenosine 5'-triphosphate
name: dATP [ChEBI:16284]
name: dATP
name: Deoxyadenosine triphosphate
xref: UnificationXref2899

SequenceSite1184
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1185
type: SequenceSite
position status: EQUAL
sequence position: 197

SequenceSite1182
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite1183
type: SequenceSite
position status: EQUAL
sequence position: 313

http://identifiers.org/pubmed/2188967
type: PublicationXref
id: 2188967
author: Hackert, ML
author: Reed, LJ
db: Pubmed
title: Structure-function relationships in dihydrolipoamide acyltransferases.
source: J Biol Chem 265:8971-4
year: 1990

EGFR interacts with phospholipase C-gamma
type: Pathway
data source: Provenance1
pathway component: REACT 112227.8
evidence: Evidence13
xref: UnificationXref189
xref: UnificationXref188
xref: RelationshipXref13
pathway order: PathwayStep12
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite2118
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2119
type: SequenceSite
position status: EQUAL
sequence position: 356

http://identifiers.org/pubmed/15337521
type: PublicationXref
id: 15337521
author: Moens, U
author: Johannessen, M
author: Delghandi, MP
db: Pubmed
title: What turns CREB on?
source: Cell Signal 16:1211-27
year: 2004

SequenceSite2116
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2117
type: SequenceSite
position status: EQUAL
sequence position: 356

Glycerophospholipid biosynthesis
type: Pathway
data source: Provenance1
pathway component: REACT 130519.5
pathway component: Acyl chain remodelling of PE
pathway component: REACT 129350.5
pathway component: REACT 132026.5
pathway component: REACT 131855.5
pathway component: REACT 131961.5
pathway component: Synthesis of PC
pathway component: Synthesis of PE
evidence: Evidence252
xref: UnificationXref2092
xref: RelationshipXref229
xref: UnificationXref2091
pathway order: PathwayStep242
pathway order: PathwayStep238
pathway order: PathwayStep232
pathway order: PathwayStep234
pathway order: PathwayStep244
pathway order: PathwayStep246
pathway order: PathwayStep227
pathway order: PathwayStep240
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite2114
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2115
type: SequenceSite
position status: EQUAL
sequence position: 340

SequenceSite706
type: SequenceSite
position status: EQUAL
sequence position: 211

SequenceSite705
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite704
type: SequenceSite
position status: EQUAL
sequence position: 217

SequenceSite703
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/15479732
type: PublicationXref
id: 15479732
author: Malmberg, RL
author: Christie, KR
author: Goldstein, LS
author: Saxton, WM
author: Dawe, RK
author: Okada, Y
author: Scholey, JM
author: Wordeman, L
author: Cleveland, DW
author: Goodson, HV
author: Miki, H
author: Dawson, SC
author: Hirokawa, N
author: McIntosh, JR
author: Mitchison, TJ
author: Vale, RD
author: Schliwa, M
author: Reddy, AS
author: Endow, SA
author: Lawrence, CJ
author: Walczak, CE
author: Howard, J
db: Pubmed
title: A standardized kinesin nomenclature
source: J Cell Biol 167:19-22
year: 2004

SequenceSite702
type: SequenceSite
position status: EQUAL
sequence position: 196