plasma membrane
type: CellularLocationVocabulary
xref: UnificationXref26

ISUPREL (TN)
type: SmallMoleculeReference
name: Isoproterenol
name: Isoproterenol [ChEBI:6046]
xref: UnificationXref243

(5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
type: SmallMoleculeReference
name: Prostaglandin D2
name: (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate [ChEBI:246]
xref: UnificationXref52

Prostaglandin F2a
type: SmallMoleculeReference
name: Prostaglandin F2alpha
name: Enzaprost
name: Prostin F 2 alpha
name: Prostaglandin F2
name: (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate
name: PGF2a
name: Prostarmon F
name: Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-,(5Z,9a,11a,13E,15S)-
name: Prostaglandin F2alpha [ChEBI:8516]
name: U 14583
name: 9a,11a-PGF2
name: Dinoprost
name: Protamodin
name: 5-Heptenoic acid, 7-[3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-
name: Panacelan
name: Cyclosin
name: (+)-Prostaglandin F2a
name: Enzaprost F
name: 7-[3, 5-dihydroxy-2-(3-hydroxy-1-octenyl) cyclopentyl]-5-heptenoic acid
name: Amoglandin
xref: UnificationXref58

Prostaglandin E2 [ChEBI:8512]
type: SmallMoleculeReference
name: (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate
name: Prostaglandin E2
name: (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate
xref: UnificationXref55

http://identifiers.org/pubmed/10549853
type: PublicationXref
id: 10549853
author: Kunimoto, M
author: Imai, H
author: Arai, M
author: Chiba, N
author: Nakagawa, Y
author: Oshima, G
author: Narashima, K
db: Pubmed
title: Cellular glutathione peroxidase as a predominant scavenger of hydroperoxyeicosatetraenoic acids in rabbit alveolar macrophages
source: Biol Pharm Bull 22:1047-51
year: 1999

(5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate [ChEBI:249]
type: SmallMoleculeReference
name: (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
xref: UnificationXref63

UnificationXref318
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Catalysis5
type: Catalysis
data source: Reactome
controlled: ANPEP Hydrolyzes Angiotensin III to Yield Angiotensin IV
control type: ACTIVATION
xref: RelationshipXref10
xref: RelationshipXref9
controller: AMPN_RABIT

UnificationXref319
type: UnificationXref
id: 29372
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372

Catalysis6
type: Catalysis
data source: Reactome
controlled: Autophosphorylation of PAK-2p34
control type: ACTIVATION
xref: RelationshipXref3
xref: RelationshipXref11
controller: PAK-2p34

Catalysis3
type: Catalysis
data source: Reactome
controlled: PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD
control type: ACTIVATION
xref: RelationshipXref5
xref: RelationshipXref6
controller: HPGD dimer

Catalysis4
type: Catalysis
data source: Reactome
controlled: Ubiquitination of PAK-2p34
control type: ACTIVATION
xref: RelationshipXref8
xref: RelationshipXref7
controller: Ubiquitin ligase

UnificationXref314
type: UnificationXref
id: 159625
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159625

Catalysis9
type: Catalysis
data source: Reactome
controlled: Digestion of trehalose to yield glucose
control type: ACTIVATION
xref: RelationshipXref16
xref: RelationshipXref17
controller: trehalase

UnificationXref315
type: UnificationXref
id: REACT_3552
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3552.1

UnificationXref316
type: UnificationXref
id: 159890
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159890

Catalysis7
type: Catalysis
data source: Reactome
controlled: reEF1A complexes with GTP
control type: ACTIVATION
xref: RelationshipXref13
xref: RelationshipXref12
controller: reEF1A

UnificationXref317
type: UnificationXref
id: REACT_5893
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5893.1

Catalysis8
type: Catalysis
data source: Reactome
controlled: Cleavage of PAK-2 at 212
control type: ACTIVATION
xref: RelationshipXref14
xref: RelationshipXref15
controller: active caspase-3

UnificationXref310
type: UnificationXref
id: REACT_13445
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13445.1

UnificationXref311
type: UnificationXref
id: CHEBI:17552
db: ChEBI

UnificationXref312
type: UnificationXref
id: 29420
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29420

UnificationXref313
type: UnificationXref
id: REACT_4014
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4014.1

Catalysis2
type: Catalysis
data source: Reactome
controlled: Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197
control type: ACTIVATION
xref: RelationshipXref3
xref: RelationshipXref4
controller: PAK-2

Catalysis1
type: Catalysis
data source: Reactome
controlled: 5S-HpETE is reduced to 5S-HETE by GPX1
control type: ACTIVATION
xref: RelationshipXref1
xref: RelationshipXref2
controller: glutathione peroxidase tetramer

UnificationXref309
type: UnificationXref
id: 213303
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213303

UnificationXref307
type: UnificationXref
id: 213298
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213298

UnificationXref308
type: UnificationXref
id: REACT_13912
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13912.1

UnificationXref305
type: UnificationXref
id: 213299
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213299

UnificationXref306
type: UnificationXref
id: REACT_14677
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14677.1

UnificationXref303
type: UnificationXref
id: 213296
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213296

http://identifiers.org/pubmed/10075701
type: PublicationXref
id: 10075701
author: Traugh, JA
author: Huang, Z
author: Tuazon, PT
author: Gatti, A
db: Pubmed
title: Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation
source: J Biol Chem 274:8022-8
year: 1999

UnificationXref304
type: UnificationXref
id: REACT_14320
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14320.1

UnificationXref301
type: UnificationXref
id: REACT_9495
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9495.2

UnificationXref302
type: UnificationXref
id: Q5U814
db: UniProt

UnificationXref300
type: UnificationXref
id: 189019
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189019

ChEBI:29265 Asn-tRNA(Asn)
type: SmallMoleculeReference
name: Asn-tRNA(Asn)
xref: UnificationXref163

alpha-D-Glucose [ChEBI:17925]
type: SmallMoleculeReference
name: alpha-D-Glucose
xref: UnificationXref293

TREA
type: ProteinReference
name: UniProt:P19813 TREH
name: TREH
xref: UnificationXref296
comment: FUNCTION Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.CATALYTIC ACTIVITY Alpha,alpha-trehalose + H(2)O = beta-D-glucose + alpha-D-glucose.SUBUNIT Homodimer; disulfide-linked.TISSUE SPECIFICITY Small intestine, kidney, and lesser in liver.SIMILARITY Belongs to the glycosyl hydrolase 37 family.
organism: Oryctolagus cuniculus

UniProt:P18762 Adrb2
type: ProteinReference
name: Adrb2r
name: Adrb2
xref: UnificationXref247
comment: FUNCTION Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.PTM Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.SIMILARITY Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
organism: Mus musculus

Guanosine 5'-diphosphate
type: SmallMoleculeReference
name: GDP
name: Guanosine diphosphate
name: GDP [ChEBI:17552]
xref: UnificationXref311

alpha,alpha-Trehalose
type: SmallMoleculeReference
name: alpha,alpha-Trehalose [ChEBI:10202]
name: Trehalose
name: alpha,alpha'-Trehalose
xref: UnificationXref290

http://identifiers.org/pubmed/3954355
type: PublicationXref
id: 3954355
author: Bergholte, JM
author: Okita, RT
db: Pubmed
title: Isolation and properties of lung 15-hydroxyprostaglandin dehydrogenase from pregnant rabbits
source: Arch Biochem Biophys 245:308-15
year: 1986

Guanosine 5'-triphosphate
type: SmallMoleculeReference
name: GTP
name: GTP [ChEBI:15996]
xref: UnificationXref147

cytosol
type: CellularLocationVocabulary
xref: UnificationXref1

Same Catalyst Activity
type: RelationshipTypeVocabulary

UniProt:G1TBB5
type: ProteinReference
name: HPGD
xref: UnificationXref80
comment: SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
organism: Oryctolagus cuniculus

http://identifiers.org/pubmed/8736705
type: PublicationXref
id: 8736705
author: Basi, NS
author: Okuya, S
author: Rebois, RV
db: Pubmed
title: GTP binding to Gs does not promote subunit dissociation
source: Cell Signal 8:209-15
year: 1996

UnificationXref272
type: UnificationXref
id: REACT_24455
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24455.1

UnificationXref271
type: UnificationXref
id: 421958
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421958

UnificationXref270
type: UnificationXref
id: REACT_24420
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24420.1

Stoichiometry21
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein subunit gamma-2
stoichiometric coefficient: 1.0

Stoichiometry22
type: Stoichiometry
physical entity: G-protein beta:gamma complex
stoichiometric coefficient: 1.0

SequenceSite29
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry20
type: Stoichiometry
physical entity: G-protein beta subunit
stoichiometric coefficient: 1.0

SequenceSite28
type: SequenceSite
position status: EQUAL
sequence position: 228

Stoichiometry25
type: Stoichiometry
physical entity: Caspase-3 (large subunit)
stoichiometric coefficient: 1.0

Stoichiometry26
type: Stoichiometry
physical entity: alpha-D-glucose
stoichiometric coefficient: 2.0

Stoichiometry23
type: Stoichiometry
physical entity: Heterotrimeric G-protein Gs (active)
stoichiometric coefficient: 1.0

Stoichiometry24
type: Stoichiometry
physical entity: Caspase-3 (small subunit)
stoichiometric coefficient: 1.0

Stoichiometry19
type: Stoichiometry
physical entity: G alpha (s):GTP
stoichiometric coefficient: 1.0

SequenceSite22
type: SequenceSite
position status: EQUAL
sequence position: 76

UnificationXref132
type: UnificationXref
id: GO:0005576
db: GENE ONTOLOGY

Stoichiometry18
type: Stoichiometry
physical entity: G(s) alpha subunit
stoichiometric coefficient: 1.0

SequenceSite23
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref133
type: UnificationXref
id: P01019
db: UniProt

Stoichiometry17
type: Stoichiometry
physical entity: Guanosine 5'-triphosphate
stoichiometric coefficient: 1.0

SequenceSite20
type: SequenceSite
position status: EQUAL
sequence position: 76

UnificationXref130
type: UnificationXref
id: 212920
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=212920

Stoichiometry16
type: Stoichiometry
physical entity: ADRB2_MOUSE
stoichiometric coefficient: 1.0

SequenceSite21
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref131
type: UnificationXref
id: REACT_13487
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13487.2

SequenceSite26
type: SequenceSite
position status: EQUAL
sequence position: 152

UnificationXref136
type: UnificationXref
id: 2022355
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2022355

SequenceSite27
type: SequenceSite
position status: EQUAL
sequence position: 153

UnificationXref137
type: UnificationXref
id: REACT_148235
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148235.2

SequenceSite24
type: SequenceSite
position status: EQUAL
sequence position: 76

UnificationXref134
type: UnificationXref
id: 2022354
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2022354

SequenceSite25
type: SequenceSite
position status: EQUAL
sequence position: 77

UnificationXref135
type: UnificationXref
id: REACT_148101
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148101.2

UnificationXref279
type: UnificationXref
id: P42574
db: UniProt

UnificationXref277
type: UnificationXref
id: 213022
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213022

UnificationXref138
type: UnificationXref
id: P15541
db: UniProt

UnificationXref278
type: UnificationXref
id: REACT_14198
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14198.1

UnificationXref139
type: UnificationXref
id: 2022347
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2022347

UnificationXref275
type: UnificationXref
id: 421961
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421961

UnificationXref276
type: UnificationXref
id: REACT_24008
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24008.2

UnificationXref273
type: UnificationXref
id: 421959
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421959

UniProt:Q5U814 Small GTP binding protein CDC42
type: ProteinReference
name: Small GTP binding protein CDC42
xref: UnificationXref302
comment: SIMILARITY Belongs to the small GTPase superfamily. Rho family.
organism: Oryctolagus cuniculus

UnificationXref274
type: UnificationXref
id: REACT_24441
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24441.1

UnificationXref261
type: UnificationXref
id: REACT_24463
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24463.1

gamma-L-Glutamyl-L-cysteinyl-glycine
type: SmallMolecule
entity reference: gamma-L-Glutamyl-L-cysteinyl-glycine
data source: Reactome
name: 5-L-Glutamyl-L-cysteinylglycine
name: N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine
name: Reduced glutathione
name: Glutathione
xref: UnificationXref7
xref: UnificationXref6
cellular location: cytosol
comment: Reactome DB_ID: 29450
display name: GSH

UnificationXref260
type: UnificationXref
id: 421955
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421955

(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
type: SmallMolecule
entity reference: 5-HPETE
data source: Reactome
xref: UnificationXref4
xref: UnificationXref3
cellular location: cytosol
comment: Reactome DB_ID: 266010
display name: 5S-HpETE

Stoichiometry30
type: Stoichiometry
physical entity: CDC42-GTP
stoichiometric coefficient: 1.0

DPN
type: SmallMolecule
entity reference: NAD
data source: Reactome
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref51
xref: UnificationXref50
cellular location: cytosol
comment: Reactome DB_ID: 29360
display name: NAD

SequenceSite18
type: SequenceSite
position status: EQUAL
sequence position: 524

Stoichiometry31
type: Stoichiometry
physical entity: reEF1A
stoichiometric coefficient: 1.0

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: ADP [ChEBI:16761]
data source: Reactome
xref: UnificationXref46
xref: UnificationXref45
cellular location: cytosol
comment: Reactome DB_ID: 29370
display name: ADP

SequenceSite17
type: SequenceSite
position status: EQUAL
sequence position: 213

Stoichiometry32
type: Stoichiometry
physical entity: Guanosine 5'-diphosphate
stoichiometric coefficient: 1.0

Stoichiometry33
type: Stoichiometry
physical entity: 80S:Met-tRNAi:mRNA
stoichiometric coefficient: 1.0

PGD2/E2/F2a
type: SmallMolecule
data source: Reactome
member physical entity: Prostaglandin E2
member physical entity: Prostaglandin F2alpha
member physical entity: Prostaglandin D2
xref: UnificationXref62
xref: UnificationXref61
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2161661

SequenceSite19
type: SequenceSite
position status: EQUAL
sequence position: 1

Stoichiometry34
type: Stoichiometry
physical entity: Aminoacyl-tRNA
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
entity reference: H2O
data source: Reactome
xref: UnificationXref12
xref: UnificationXref13
cellular location: cytosol
comment: Reactome DB_ID: 29356
display name: H2O

glutathione disulfide
type: SmallMolecule
entity reference: Glutathione disulfide
data source: Reactome
name: oxidized glutathione
xref: UnificationXref9
xref: UnificationXref10
cellular location: cytosol
comment: Reactome DB_ID: 111745
display name: GSSG

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: Adenosine 5'-triphosphate
data source: Reactome
xref: UnificationXref39
xref: UnificationXref40
cellular location: cytosol
comment: Reactome DB_ID: 113592
display name: ATP

5S-HETE
type: SmallMolecule
entity reference: 5-HETE
data source: Reactome
xref: UnificationXref15
xref: UnificationXref16
cellular location: cytosol
comment: Reactome DB_ID: 2142733

Stoichiometry28
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

Stoichiometry27
type: Stoichiometry
physical entity: Guanosine 5'-triphosphate
stoichiometric coefficient: 1.0

SequenceSite10
type: SequenceSite
position status: EQUAL
sequence position: 20

UnificationXref120
type: UnificationXref
id: REACT_24411
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24411.2

SequenceSite11
type: SequenceSite
position status: EQUAL
sequence position: 55

UnificationXref121
type: UnificationXref
id: 939165
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939165

Stoichiometry29
type: Stoichiometry
physical entity: partially auto-phosphorylated PAK-2 (inactive)
stoichiometric coefficient: 1.0

SequenceSite12
type: SequenceSite
position status: EQUAL
sequence position: 192

UnificationXref122
type: UnificationXref
id: REACT_24885
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24885.2

SequenceSite13
type: SequenceSite
position status: EQUAL
sequence position: 197

UnificationXref123
type: UnificationXref
id: 113595
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113595

SERPINA8
type: ProteinReference
name: AGT
name: UniProt:P01019 AGT
xref: UnificationXref133
comment: FUNCTION Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.FUNCTION Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.FUNCTION Angiotensin-3: stimulates aldosterone release.SUBUNIT During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.TISSUE SPECIFICITY Expressed by the liver and secreted in plasma.PTM Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.PTM In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).PTM The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.DISEASE Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal wi…
organism: Homo sapiens

SequenceSite14
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref124
type: UnificationXref
id: REACT_3316
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3316.3

SequenceSite15
type: SequenceSite
position status: EQUAL
sequence position: 524

UnificationXref125
type: UnificationXref
id: MOD:01148
db: MOD

SequenceSite16
type: SequenceSite
position status: EQUAL
sequence position: 402

UnificationXref126
type: UnificationXref
id: 3095872
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3095872

UnificationXref266
type: UnificationXref
id: REACT_24483
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24483.1

UnificationXref127
type: UnificationXref
id: REACT_161061
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161061.1

UnificationXref267
type: UnificationXref
id: 421948
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421948

UnificationXref128
type: UnificationXref
id: 69593
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69593

UnificationXref268
type: UnificationXref
id: REACT_24592
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24592.1

UnificationXref129
type: UnificationXref
id: REACT_4282
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4282.1

UnificationXref269
type: UnificationXref
id: 421950
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421950

UnificationXref262
type: UnificationXref
id: Q6PNB6
db: UniProt

UnificationXref263
type: UnificationXref
id: 421942
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421942

UnificationXref264
type: UnificationXref
id: REACT_24447
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24447.1

UnificationXref265
type: UnificationXref
id: 421945
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421945

UnificationXref250
type: UnificationXref
id: 113572
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113572

UnificationXref151
type: UnificationXref
id: 159543
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159543

UnificationXref150
type: UnificationXref
id: P68105
db: UniProt

UniProt:P19941 GHR
type: ProteinReference
name: GHR
xref: UnificationXref27
comment: FUNCTION The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.SUBUNIT On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain (By similarity). Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation (By similarity). Interacts with ADAM17.DOMAIN The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.DOMAIN The box 1 motif is required for JAK interaction and/or activation.DOMAIN The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).DOMAIN The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.PTM The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. Shedding is inhibited by growth hormone (GH) binding to the receptor probably due to a conformational change in GHR rendering the receptor inaccessible to ADAM17.PTM On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization.SIMILARITY Belongs to the type I cytokine receptor family. Type 1 subfamily.SIMILARITY Contains 1 fibronectin type-III domain.
organism: Oryctolagus cuniculus

UnificationXref158
type: UnificationXref
id: 379700
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379700

UnificationXref159
type: UnificationXref
id: REACT_17687
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17687.1

UnificationXref259
type: UnificationXref
id: REACT_24740
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24740.1

UnificationXref156
type: UnificationXref
id: REACT_145
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145.3

UnificationXref157
type: UnificationXref
id: CHEBI:17732
db: ChEBI

UnificationXref154
type: UnificationXref
id: REACT_4917
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4917.1

UnificationXref155
type: UnificationXref
id: 159534
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159534

UnificationXref152
type: UnificationXref
id: REACT_4440
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4440.1

UnificationXref153
type: UnificationXref
id: 159530
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159530

UnificationXref253
type: UnificationXref
id: 421934
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421934

UnificationXref254
type: UnificationXref
id: REACT_24345
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24345.1

UnificationXref251
type: UnificationXref
id: REACT_3646
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3646.1

UnificationXref252
type: UnificationXref
id: Q6X973
db: UniProt

UnificationXref257
type: UnificationXref
id: REACT_24600
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24600.1

UnificationXref258
type: UnificationXref
id: 421937
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421937

H+ [ChEBI:15378]
type: SmallMoleculeReference
name: H+
xref: UnificationXref77

UnificationXref255
type: UnificationXref
id: 2003375B
db: PRF

H2O
type: SmallMoleculeReference
name: Water
name: H2O [ChEBI:15377]
xref: UnificationXref11

UnificationXref256
type: UnificationXref
id: 421933
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421933

nucleoplasm
type: CellularLocationVocabulary
xref: UnificationXref238

G alpha (s):GTP
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry17
component stoichiometry: Stoichiometry18
component: G(s) alpha subunit
component: Guanosine 5'-triphosphate
xref: UnificationXref260
xref: UnificationXref261
cellular location: plasma membrane
comment: Reactome DB_ID: 421955

ADP [ChEBI:16761]
type: SmallMoleculeReference
name: ADP
name: Adenosine 5'-diphosphate
xref: UnificationXref44

Heterotrimeric G-protein Gs (active)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry22
component stoichiometry: Stoichiometry19
component: G-protein beta:gamma complex
component: G alpha (s):GTP
xref: UnificationXref271
xref: UnificationXref272
cellular location: plasma membrane
comment: Reactome DB_ID: 421958

Isoprotenerol:beta-2 adrenergic receptor:G-protein G(s) (active)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry23
component stoichiometry: Stoichiometry15
component stoichiometry: Stoichiometry16
component: Heterotrimeric G-protein Gs (active)
component: Isoprotenerol
component: ADRB2_MOUSE
xref: UnificationXref274
xref: UnificationXref273
cellular location: plasma membrane
comment: Reactome DB_ID: 421959

80S:mRNA:amino acyl-tRNA:mRNA:reEF1A:GTP
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry13
component stoichiometry: Stoichiometry14
component: reEF1A:GTP:Aminoacyl-tRNA complex
component: 80S:Met-tRNAi:mRNA
xref: UnificationXref232
xref: UnificationXref233
cellular location: cytosol
comment: Reactome DB_ID: 159883

Stoichiometry12
type: Stoichiometry
physical entity: 80S ribosome
stoichiometric coefficient: 1.0

80S:Met-tRNAi:mRNA
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry12
component stoichiometry: Stoichiometry10
component stoichiometry: Stoichiometry11
component: 80S ribosome
component: fMet-tRNA
component: messenger RNA
xref: UnificationXref231
xref: UnificationXref230
cellular location: cytosol
comment: Reactome DB_ID: 159893

Stoichiometry13
type: Stoichiometry
physical entity: 80S:Met-tRNAi:mRNA
stoichiometric coefficient: 1.0

reEF1A:GTP:Aminoacyl-tRNA complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry9
component stoichiometry: Stoichiometry8
component: reEF1A:GTP
component: Aminoacyl-tRNA
xref: UnificationXref220
xref: UnificationXref219
cellular location: cytosol
comment: Reactome DB_ID: 159538

Stoichiometry14
type: Stoichiometry
physical entity: reEF1A:GTP:Aminoacyl-tRNA complex
stoichiometric coefficient: 1.0

reEF1A:GTP
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry6
component stoichiometry: Stoichiometry7
component: Guanosine 5'-triphosphate
component: reEF1A
xref: UnificationXref153
xref: UnificationXref154
cellular location: cytosol
comment: Reactome DB_ID: 159530

UnificationXref140
type: UnificationXref
id: REACT_148322
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148322.1

Stoichiometry15
type: Stoichiometry
physical entity: Isoprotenerol
stoichiometric coefficient: 1.0

HPGD dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry5
component: G1TBB5_RABIT
xref: UnificationXref83
xref: UnificationXref84
cellular location: cytosol
comment: Reactome DB_ID: 2142782

glutathione peroxidase tetramer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry2
component: GPX1_RABIT
xref: UnificationXref21
xref: UnificationXref22
cellular location: cytosol
display name: GPX1 tetramer
comment: Reactome DB_ID: 2142680

Stoichiometry10
type: Stoichiometry
physical entity: fMet-tRNA
stoichiometric coefficient: 1.0

Stoichiometry11
type: Stoichiometry
physical entity: messenger RNA
stoichiometric coefficient: 1.0

UnificationXref248
type: UnificationXref
id: 421951
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421951

UnificationXref145
type: UnificationXref
id: 211638
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211638

UnificationXref249
type: UnificationXref
id: REACT_24288
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24288.1

UnificationXref146
type: UnificationXref
id: REACT_13817
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13817.1

UnificationXref147
type: UnificationXref
id: CHEBI:15996
db: ChEBI

UnificationXref148
type: UnificationXref
id: 29438
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438

UnificationXref141
type: UnificationXref
id: 2022369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2022369

UnificationXref142
type: UnificationXref
id: REACT_147750
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147750.2

UnificationXref143
type: UnificationXref
id: 211637
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211637

UnificationXref144
type: UnificationXref
id: REACT_14043
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14043.1

UnificationXref240
type: UnificationXref
id: REACT_14500
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14500.1

UnificationXref241
type: UnificationXref
id: 266151
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266151

UnificationXref242
type: UnificationXref
id: REACT_13654
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13654.1

UnificationXref243
type: UnificationXref
id: CHEBI:4495
db: ChEBI

UnificationXref244
type: UnificationXref
id: 421954
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=421954

UnificationXref149
type: UnificationXref
id: REACT_2875
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2875.1

UnificationXref245
type: UnificationXref
id: REACT_24559
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24559.2

UnificationXref246
type: UnificationXref
id: 10090
db: NCBI Taxonomy

endosome lumen
type: CellularLocationVocabulary
xref: UnificationXref30

UnificationXref247
type: UnificationXref
id: P18762
db: UniProt

Catalysis10
type: Catalysis
data source: Reactome
controlled: Hydrolysis of reEF1A:GTP
control type: ACTIVATION
xref: RelationshipXref18
xref: RelationshipXref19
controller: 80S ribosome

UnificationXref236
type: UnificationXref
id: 266144
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266144

UnificationXref235
type: UnificationXref
id: REACT_1353
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1353.3

UnificationXref234
type: UnificationXref
id: 159620
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159620

UnificationXref233
type: UnificationXref
id: REACT_5056
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5056.1

UnificationXref232
type: UnificationXref
id: 159883
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159883

UnificationXref231
type: UnificationXref
id: REACT_2946
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2946.1

UnificationXref230
type: UnificationXref
id: 159893
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159893

UnificationXref239
type: UnificationXref
id: 266149
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266149

UnificationXref238
type: UnificationXref
id: GO:0005654
db: GENE ONTOLOGY

UnificationXref237
type: UnificationXref
id: REACT_14232
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14232.1

extracellular region
type: CellularLocationVocabulary
xref: UnificationXref132

http://identifiers.org/pubmed/1978675
type: PublicationXref
id: 1978675
author: Benter, IF
author: Dick, L
author: Wilk, S
author: Ward, PE
db: Pubmed
title: Metabolism of vasoactive peptides by plasma and purified renal aminopeptidase M
source: Biochem Pharmacol 40:1725-32
year: 1990

EEF1A1
type: ProteinReference
name: EEF1A
name: EF1A
name: UniProt:P68105 EEF1A1
xref: UnificationXref150
comment: TISSUE SPECIFICITY Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.PTM The N-terminus is blocked.SIMILARITY Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.
organism: Oryctolagus cuniculus

UnificationXref223
type: UnificationXref
id: 72393
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72393

UnificationXref222
type: UnificationXref
id: REACT_755
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_755.3

UnificationXref320
type: UnificationXref
id: REACT_2728
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2728.2

UnificationXref225
type: UnificationXref
id: CHEBI:33699
db: ChEBI

UnificationXref224
type: UnificationXref
id: REACT_4829
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4829.1

UnificationXref322
type: UnificationXref
id: REACT_712
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_712.3

UnificationXref321
type: UnificationXref
id: 159603
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159603

UnificationXref221
type: UnificationXref
id: 159540
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159540

UnificationXref220
type: UnificationXref
id: REACT_4375
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4375.1

UniProt:P11909 GPX1
type: ProteinReference
name: GPX1
xref: UnificationXref18
comment: FUNCTION Protects the hemoglobin in erythrocytes from oxidative breakdown.CATALYTIC ACTIVITY 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.SIMILARITY Belongs to the glutathione peroxidase family.
organism: Oryctolagus cuniculus

http://identifiers.org/pubmed/17488973
type: PublicationXref
id: 17488973
author: Yang, N
author: Wang, X
author: He, K
author: Jiang, J
author: Frank, SJ
author: Thangavel, C
author: Deng, L
author: Fuchs, SY
db: Pubmed
title: Determinants of growth hormone receptor down-regulation
source: Mol Endocrinol 21:1537-51
year: 2007

UnificationXref227
type: UnificationXref
id: REACT_3563
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3563.1

UnificationXref226
type: UnificationXref
id: 162612
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=162612

UnificationXref229
type: UnificationXref
id: REACT_4521
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4521.1

UnificationXref228
type: UnificationXref
id: 159892
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159892

15-Keto-PGF2a
type: SmallMoleculeReference
name: 15-Keto-prostaglandin F2alpha
name: 15-Keto-prostaglandin F2alpha [ChEBI:760]
name: 15-Keto-prostaglandin F2a
name: 15-Keto-PGF2alpha
xref: UnificationXref69

http://identifiers.org/pubmed/6568109
type: PublicationXref
id: 6568109
author: Carvalho, JF
author: Carvalho, MD
author: Merrick, WC
db: Pubmed
title: Biological characterization of various forms of elongation factor 1 from rabbit reticulocytes
source: Arch Biochem Biophys 234:603-11
year: 1984

UnificationXref210
type: UnificationXref
id: REACT_17447
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17447.1

UnificationXref214
type: UnificationXref
id: CHEBI:29164
db: ChEBI

UnificationXref119
type: UnificationXref
id: 939239
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939239

UnificationXref213
type: UnificationXref
id: REACT_18116
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18116.1

UnificationXref118
type: UnificationXref
id: REACT_24496
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24496.2

UniProt:P62987 UBA52
type: ProteinReference
name: UBCEP2
name: UBA52
xref: UnificationXref94
comment: FUNCTION Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.FUNCTION Ribosomal protein L40 is a component of the 60S subunit of the ribosome.MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the …
organism: Homo sapiens

UnificationXref212
type: UnificationXref
id: 379785
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379785

UnificationXref117
type: UnificationXref
id: 939184
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939184

UnificationXref211
type: UnificationXref
id: CHEBI:29161
db: ChEBI

UnificationXref116
type: UnificationXref
id: REACT_24153
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24153.2

Aminoacyl-tRNA binds to the ribosome at the A-site
type: BiochemicalReaction
data source: Reactome
xref: http://identifiers.org/pubmed/6568109
xref: UnificationXref235
xref: UnificationXref234
left: reEF1A:GTP:Aminoacyl-tRNA complex
left: 80S:Met-tRNAi:mRNA
comment: At the beginning of this reaction, 1 molecule of '80S:Met-tRNAi:mRNA', and 1 molecule of 'reEF1A:GTP:Aminoacyl-tRNA complex' are present. At the end of this reaction, 1 molecule of '80S:mRNA:amino acyl-tRNA:mRNA:reEF1A:GTP' is present.
right: 80S:mRNA:amino acyl-tRNA:mRNA:reEF1A:GTP

UnificationXref218
type: UnificationXref
id: REACT_4792
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4792.1

UnificationXref115
type: UnificationXref
id: 939191
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939191

Proteolytic PAK-2p34 fragment translocates to the nucleus
type: BiochemicalReaction
data source: Reactome
xref: http://identifiers.org/pubmed/12853446
xref: UnificationXref242
xref: UnificationXref241
left: phospho-PAK-2p34 (Thr 402)
comment: Edited: Matthews, L, 2008-06-03 00:23:29
comment: The subcellular localization of PAK-2 is controlled by nuclear localization and nuclear export signal motifs (Jakobi et al.,2003). The regulatory domain contains a nuclear export signal motif that prevents the nuclear accumulation of full-length PAK-2. The activating proteolytic cleavage disrupts the nuclear export signal in PAK-2 and removes most its regulatory domain. The resulting activated PAK-2p34 fragment contains a nuclear localization signal and translocates to and is retained in the nucleus (Jakobi et al.,2003).
comment: Reviewed: Chang, E, 2008-05-21 00:05:41
comment: Edited: Matthews, L, 2008-02-03 20:50:13
comment: Authored: Jakobi, R, 2008-02-05 11:04:14
right: phospho-PAK-2p34 (Thr 402)

UnificationXref217
type: UnificationXref
id: 37001
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=37001

UnificationXref114
type: UnificationXref
id: REACT_24675
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24675.2

Dissociation of beta-2 adrenergic receptor:Gs complex
type: BiochemicalReaction
data source: Reactome
xref: http://identifiers.org/pubmed/8736705
xref: UnificationXref275
xref: http://identifiers.org/pubmed/3141418
xref: UnificationXref276
left: Isoprotenerol:beta-2 adrenergic receptor:G-protein G(s) (active)
comment: Reviewed: Kunapuli, SP, 2010-06-07
comment: Edited: Jupe, S, 2010-06-07
comment: The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
comment: Authored: Jupe, S, 2009-05-22 08:30:21
right: G-protein beta:gamma complex
right: G alpha (s):GTP
right: Isoprotenerol
right: ADRB2_MOUSE

UnificationXref216
type: UnificationXref
id: REACT_15717
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15717.1

UnificationXref113
type: UnificationXref
id: 939232
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939232

Cleavage of PAK-2 at 212
type: BiochemicalReaction
data source: Reactome
EC number: 3.4.22
xref: http://identifiers.org/pubmed/12853446
xref: http://identifiers.org/pubmed/9786869
xref: UnificationXref287
xref: UnificationXref286
left: partially auto-phosphorylated PAK-2 (inactive)
comment: Edited: Matthews, L, 2008-06-02 08:04:50
comment: Reviewed: Chang, E, 2008-05-21 00:05:41
comment: Edited: Matthews, L, 2008-02-03 20:50:13
comment: Authored: Jakobi, R, 2008-02-05 11:04:14
comment: p21-activated protein kinase (PAK-2), also known as gamma-PAK, is cleaved by caspase-3 during apoptosis and plays a role in regulating cell death. Cleavage produces two peptides; 1-212 containing most of the regulatory domain and 213-524 containing 34 amino acids of the regulatory domain as well as the catalytic domain (Walter et al., 1998). Proteolytic cleavage of PAK by caspase-3 creates the constitutively active PAK-2p34 fragment (Jakobi et al., 2003). Evidence for this reaction comes from experiments using both human and rabbit proteins.
right: Auto-phosphorylated PAK-2 (p27 regulatory fragment)
right: PAK-2p34

UnificationXref215
type: UnificationXref
id: 379790
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379790

UnificationXref112
type: UnificationXref
id: REACT_24880
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24880.2

Phosphate
type: SmallMoleculeReference
name: Orthophosphate
name: Orthophosphate [ChEBI:18367]
name: Inorganic Phosphate
xref: UnificationXref318

Digestion of trehalose to yield glucose
type: BiochemicalReaction
data source: Reactome
EC number: 3.2.1.28
xref: http://identifiers.org/pubmed/1697585
xref: UnificationXref300
xref: http://identifiers.org/pubmed/6466686
xref: http://identifiers.org/pubmed/9427547
xref: UnificationXref301
participant stoichiometry: Stoichiometry26
left: alpha,alpha-trehalose
left: water
display name: trehalose + H2O => 2 D-glucose
comment: Reviewed: Nichols, BL, 2007-01-15 21:51:24
comment: Authored: D'Eustachio, P, 2006-11-03 14:36:07
comment: Extracellular trehalose, a disaccharide, is cleaved by trehalase associated with the plasma membrane to yield two molecules of glucose. Trehalase has been purified to homogeneity from rabbit intestine and shown to be a monomer attached to the plasma membrane by a GPI anchor (Galand 1984; Ruf et al. 1990). A human cDNA encoding a closely homologous protein has been cloned and the protein product of the clone has been shown to have trehalase activity in vitro (Ishihara et al. 1997). The human enzyme has not been characterized further, and so both the posttranslational modifications of the human enzyme and its activity in vivo have been inferred from the properties of the well studied rabbit enzyme.
right: alpha-D-glucose

UnificationXref111
type: UnificationXref
id: 939192
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939192

Association of Pak2 with Cdc42-GTP
type: BiochemicalReaction
data source: Reactome
xref: UnificationXref309
xref: http://identifiers.org/pubmed/10075701
xref: UnificationXref310
xref: http://identifiers.org/pubmed/16204230
left: CDC42-GTP
left: partially auto-phosphorylated PAK-2 (inactive)
comment: Edited: Matthews, L, 2008-02-03 20:50:13
comment: Authored: Traugh, JA, Jung, JH, 2008-02-06 09:37:35
comment: Inactive PAK-2 is partially autophosphorylated at 5 serine sites in the regulatory domain (Gatti et al. 1999). PAK-2 associates with Cdc42(GTP) by binding to the p21 binding domain (PBD) of PAK-2 (Jung and Traugh, 2005).
comment: Reviewed: Jakobi, R, 2008-02-25 02:02:42
right: Inactive Pak2:Cdc42-GTP complex

UnificationXref110
type: UnificationXref
id: REACT_24765
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24765.2

Hydrolysis of reEF1A:GTP
type: BiochemicalReaction
data source: Reactome
EC number: 3.6.5.1
EC number: 3.6.5.3
EC number: 3.6.5.2
EC number: 3.6.5.4
xref: http://identifiers.org/pubmed/6568109
xref: UnificationXref322
xref: UnificationXref321
left: 80S:mRNA:amino acyl-tRNA:mRNA:reEF1A:GTP
comment: At the beginning of this reaction, 1 molecule of '80S:mRNA:amino acyl-tRNA:mRNA:reEF1A:GTP' is present. At the end of this reaction, 1 molecule of 'reEF1A:GDP', 1 molecule of '80S:Met-tRNAi:mRNA:aa-tRNA', and 1 molecule of 'Orthophosphate' are present. This reaction is mediated by the 'GTPase activity' of '80S ribosome'.
right: Phosphate
right: reEF1A:GDP
right: 80S:Met-tRNAi:mRNA:aa-tRNA

Arg-tRNA(Arg)
type: SmallMoleculeReference
name: ChEBI:18366 Arg-tRNA(Arg)
xref: UnificationXref160

UnificationXref219
type: UnificationXref
id: 159538
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159538

GNB5
type: ProteinReference
name: UniProt:Q6PNB6 GNB5
xref: UnificationXref262
comment: FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SIMILARITY Belongs to the WD repeat G protein beta family.SIMILARITY Contains 7 WD repeats.
organism: Oryctolagus cuniculus

UBA80
type: ProteinReference
name: UniProt:P62979 RPS27A
name: RPS27A
name: UBCEP1
xref: UnificationXref91
comment: FUNCTION Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.FUNCTION Ribosomal protein S27a is a component of the 40S subunit of the ribosome.MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the…
organism: Homo sapiens

UnificationXref109
type: UnificationXref
id: 939258
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939258

ubiquitinylated lysine
type: SequenceModificationVocabulary
xref: UnificationXref125

UnificationXref201
type: UnificationXref
id: REACT_17288
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17288.1

UnificationXref106
type: UnificationXref
id: REACT_24844
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24844.2

UnificationXref200
type: UnificationXref
id: 379746
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379746

UnificationXref105
type: UnificationXref
id: 939188
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939188

UnificationXref203
type: UnificationXref
id: 379738
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379738

UnificationXref108
type: UnificationXref
id: REACT_24312
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24312.2

UnificationXref202
type: UnificationXref
id: CHEBI:29162
db: ChEBI

UnificationXref107
type: UnificationXref
id: 939164
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939164

UnificationXref205
type: UnificationXref
id: CHEBI:29163
db: ChEBI

UnificationXref102
type: UnificationXref
id: 939230
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939230

UnificationXref204
type: UnificationXref
id: REACT_17419
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17419.1

UnificationXref101
type: UnificationXref
id: REACT_24504
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24504.2

UnificationXref207
type: UnificationXref
id: REACT_17415
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17415.1

UnificationXref104
type: UnificationXref
id: P0CG48
db: UniProt

UnificationXref206
type: UnificationXref
id: 379783
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379783

UnificationXref103
type: UnificationXref
id: REACT_24537
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24537.2

UnificationXref209
type: UnificationXref
id: 379765
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379765

UnificationXref208
type: UnificationXref
id: CHEBI:29159
db: ChEBI

UnificationXref100
type: UnificationXref
id: 939213
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939213

UnificationXref40
type: UnificationXref
id: REACT_2812
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2812.1

UnificationXref41
type: UnificationXref
id: MOD:00046
db: MOD

UnificationXref44
type: UnificationXref
id: CHEBI:16761
db: ChEBI

UnificationXref45
type: UnificationXref
id: 29370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370

UnificationXref42
type: UnificationXref
id: 213304
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213304

UnificationXref43
type: UnificationXref
id: REACT_14673
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14673.1

UnificationXref38
type: UnificationXref
id: CHEBI:15422
db: ChEBI

UnificationXref37
type: UnificationXref
id: REACT_14146
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14146.1

UnificationXref36
type: UnificationXref
id: 211648
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211648

UnificationXref35
type: UnificationXref
id: Q29502
db: UniProt

UnificationXref39
type: UnificationXref
id: 113592
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592

CASP3
type: ProteinReference
name: CPP32
name: UniProt:P42574 CASP3
xref: UnificationXref279
comment: FUNCTION Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.CATALYTIC ACTIVITY Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.ENZYME REGULATION Inhibited by isatin sulfonamides.SUBUNIT Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce.TISSUE SPECIFICITY Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.PTM Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.PTM S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.SIMILARI…
organism: Homo sapiens

UnificationXref50
type: UnificationXref
id: 29360
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29360

UnificationXref51
type: UnificationXref
id: REACT_5381
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5381.1

UnificationXref52
type: UnificationXref
id: CHEBI:15555
db: ChEBI

UnificationXref53
type: UnificationXref
id: 879629
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879629

UnificationXref54
type: UnificationXref
id: REACT_24396
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24396.2

UnificationXref55
type: UnificationXref
id: CHEBI:15551
db: ChEBI

UnificationXref56
type: UnificationXref
id: 265287
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265287

UnificationXref47
type: UnificationXref
id: 213297
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213297

UnificationXref46
type: UnificationXref
id: REACT_2741
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2741.1

UnificationXref49
type: UnificationXref
id: CHEBI:15846
db: ChEBI

UnificationXref48
type: UnificationXref
id: REACT_13581
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13581.1

Glu-tRNA(Glu)
type: SmallMoleculeReference
name: ChEBI:29157 Glu-tRNA(Glu)
xref: UnificationXref175

RelationshipXref8
type: RelationshipXref
id: 69594
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69594

ChEBI:29156 Gly-tRNA(Gly)
type: SmallMoleculeReference
name: Gly-tRNA(Gly)
xref: UnificationXref178

RelationshipXref7
type: RelationshipXref
id: GO:0004842
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

ChEBI:29159 Trp-tRNA(Trp)
type: SmallMoleculeReference
name: Trp-tRNA(Trp)
xref: UnificationXref208

RelationshipXref6
type: RelationshipXref
id: 2161572
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161572

ChEBI:29158 Asp-tRNA(Asp)
type: SmallMoleculeReference
name: Asp-tRNA(Asp)
xref: UnificationXref166

RelationshipXref5
type: RelationshipXref
id: GO:0016404
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref9
type: RelationshipXref
id: GO:0008237
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

Cys-tRNA(Cys)
type: SmallMolecule
entity reference: ChEBI:29152 Cys-tRNA(Cys)
data source: Reactome
xref: UnificationXref171
xref: UnificationXref170
cellular location: cytosol
comment: Reactome DB_ID: 379719

UnificationXref22
type: UnificationXref
id: REACT_151975
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151975.1

Gln-tRNA(Gln)
type: SmallMolecule
entity reference: ChEBI:29166 Gln-tRNA(Gln)
data source: Reactome
xref: UnificationXref173
xref: UnificationXref174
cellular location: cytosol
comment: Reactome DB_ID: 379772

UnificationXref23
type: UnificationXref
id: MI:0355
db: MI

Adenosine 5'-triphosphate
type: SmallMoleculeReference
name: ATP
name: ATP [ChEBI:15422]
xref: UnificationXref38

Asn-tRNA(Asn)
type: SmallMolecule
entity reference: ChEBI:29265 Asn-tRNA(Asn)
data source: Reactome
xref: UnificationXref165
xref: UnificationXref164
cellular location: cytosol
comment: Reactome DB_ID: 379728

UnificationXref20
type: UnificationXref
id: REACT_151039
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151039.1

Asp-tRNA(Asp)
type: SmallMolecule
entity reference: ChEBI:29158 Asp-tRNA(Asp)
data source: Reactome
xref: UnificationXref168
xref: UnificationXref167
cellular location: cytosol
comment: Reactome DB_ID: 379707

UnificationXref21
type: UnificationXref
id: 2142680
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142680

ChEBI:29153 Phe-tRNA(Phe)
type: SmallMoleculeReference
name: Phe-tRNA(Phe)
xref: UnificationXref196

Ala-tRNA(Ala)
type: SmallMolecule
entity reference: ChEBI:17732 Ala-tRNA(Ala)
data source: Reactome
xref: UnificationXref159
xref: UnificationXref158
cellular location: cytosol
comment: Reactome DB_ID: 379700

ChEBI:29152 Cys-tRNA(Cys)
type: SmallMoleculeReference
name: Cys-tRNA(Cys)
xref: UnificationXref169

Arg-tRNA(Arg)
type: SmallMolecule
entity reference: Arg-tRNA(Arg)
data source: Reactome
xref: UnificationXref162
xref: UnificationXref161
cellular location: cytosol
comment: Reactome DB_ID: 379720

His-tRNA(His)
type: SmallMoleculeReference
name: ChEBI:29155 His-tRNA(His)
xref: UnificationXref181

Pro-tRNA(Pro)
type: SmallMoleculeReference
name: ChEBI:29154 Pro-tRNA(Pro)
xref: UnificationXref199

Aminoacyl-tRNA
type: SmallMolecule
data source: Reactome
member physical entity: Thr-tRNA(Thr)
member physical entity: Trp-tRNA(Trp)
member physical entity: Gly-tRNA(Gly)
member physical entity: Leu-tRNA(Leu)
member physical entity: Cys-tRNA(Cys)
member physical entity: Arg-tRNA(Arg)
member physical entity: Ile-tRNA(Ile)
member physical entity: Glu-tRNA(Glu)
member physical entity: Met-tRNA(Met)
member physical entity: Gln-tRNA(Gln)
member physical entity: Ser-tRNA(Ser)
member physical entity: Lys-tRNA(Lys)
member physical entity: Val-tRNA(Val)
member physical entity: Asp-tRNA(Asp)
member physical entity: His-tRNA(His)
member physical entity: Tyr-tRNA(Tyr)
member physical entity: Ala-tRNA(Ala)
member physical entity: Phe-tRNA(Phe)
member physical entity: Pro-tRNA(Pro)
member physical entity: Asn-tRNA(Asn)
xref: UnificationXref218
xref: UnificationXref217
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 37001

UnificationXref19
type: UnificationXref
id: 2142684
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142684

N-seryl-glycosylphosphatidylinositolethanolamine
type: SequenceModificationVocabulary
xref: UnificationXref297

UnificationXref18
type: UnificationXref
id: P11909
db: UniProt

UnificationXref17
type: UnificationXref
id: 9986
db: NCBI Taxonomy

UnificationXref16
type: UnificationXref
id: REACT_151106
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151106.1

His-tRNA(His)
type: SmallMolecule
entity reference: His-tRNA(His)
data source: Reactome
xref: UnificationXref183
xref: UnificationXref182
cellular location: cytosol
comment: Reactome DB_ID: 379786

UnificationXref15
type: UnificationXref
id: 2142733
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142733

Gly-tRNA(Gly)
type: SmallMolecule
entity reference: ChEBI:29156 Gly-tRNA(Gly)
data source: Reactome
xref: UnificationXref179
xref: UnificationXref180
cellular location: cytosol
comment: Reactome DB_ID: 379784

UnificationXref14
type: UnificationXref
id: CHEBI:28209
db: ChEBI

Glu-tRNA(Glu)
type: SmallMolecule
entity reference: Glu-tRNA(Glu)
data source: Reactome
xref: UnificationXref177
xref: UnificationXref176
cellular location: cytosol
comment: Reactome DB_ID: 379751

UnificationXref13
type: UnificationXref
id: REACT_3683
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3683.1

Mus musculus
type: BioSource
xref: UnificationXref246

Homo sapiens
type: BioSource
xref: UnificationXref90

Oryctolagus cuniculus
type: BioSource
xref: UnificationXref17

Ser-tRNA(Ser)
type: SmallMoleculeReference
name: ChEBI:29162 Ser-tRNA(Ser)
xref: UnificationXref202

Prostaglandin F2alpha
type: SmallMolecule
entity reference: Prostaglandin F2a
data source: Reactome
xref: UnificationXref59
xref: UnificationXref60
cellular location: cytosol
comment: Reactome DB_ID: 879535
display name: PGF2a

UnificationXref31
type: UnificationXref
id: 1169266
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1169266

Tyr-tRNA(Tyr)
type: SmallMoleculeReference
name: ChEBI:29161 Tyr-tRNA(Tyr)
xref: UnificationXref211

15k-PGD2/E2/F2a
type: SmallMolecule
data source: Reactome
member physical entity: 15k-PGD2
member physical entity: 15k-PGF2a
member physical entity: 15k-PGE2
xref: UnificationXref73
xref: UnificationXref72
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2161597

UnificationXref32
type: UnificationXref
id: REACT_111331
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111331.1

Ile-tRNA(Ile)
type: SmallMoleculeReference
name: ChEBI:29160 Ile-tRNA(Ile)
xref: UnificationXref184

15k-PGD2
type: SmallMolecule
entity reference: (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate [ChEBI:249]
data source: Reactome
xref: UnificationXref65
xref: UnificationXref64
cellular location: cytosol
comment: Reactome DB_ID: 2142752

UnificationXref33
type: UnificationXref
id: 1169264
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1169264

15k-PGE2
type: SmallMolecule
entity reference: (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate
data source: Reactome
xref: UnificationXref68
xref: UnificationXref67
cellular location: cytosol
comment: Reactome DB_ID: 2142721

UnificationXref34
type: UnificationXref
id: REACT_111154
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111154.1

ChEBI:29166 Gln-tRNA(Gln)
type: SmallMoleculeReference
name: Gln-tRNA(Gln)
xref: UnificationXref172

Guanine nucleotide-binding protein Gs alpha1
type: ProteinReference
name: UniProt:Q6X973 Guanine nucleotide-binding protein Gs alpha1
xref: UnificationXref252
comment: <submittedName> <fullName>Guanine nucleotide-binding protein Gs alpha1</fullName> </submittedName>
organism: Oryctolagus cuniculus

Val-tRNA(Val)
type: SmallMoleculeReference
name: ChEBI:29164 Val-tRNA(Val)
xref: UnificationXref214

Prostaglandin D2
type: SmallMolecule
entity reference: (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
data source: Reactome
xref: UnificationXref53
xref: UnificationXref54
cellular location: cytosol
comment: Reactome DB_ID: 879629
display name: PGD2

Thr-tRNA(Thr)
type: SmallMoleculeReference
name: ChEBI:29163 Thr-tRNA(Thr)
xref: UnificationXref205

Prostaglandin E2
type: SmallMolecule
entity reference: Prostaglandin E2 [ChEBI:8512]
data source: Reactome
xref: UnificationXref56
xref: UnificationXref57
cellular location: cytosol
comment: Reactome DB_ID: 265287
display name: PGE2

UnificationXref30
type: UnificationXref
id: GO:0031904
db: GENE ONTOLOGY

UnificationXref29
type: UnificationXref
id: REACT_111364
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111364.1

ChEBI:16047 Lys-tRNA(Lys)
type: SmallMoleculeReference
name: Lys-tRNA(Lys)
xref: UnificationXref190

UnificationXref28
type: UnificationXref
id: 1169260
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1169260

NADH
type: SmallMolecule
entity reference: NADH
data source: Reactome
xref: UnificationXref75
xref: UnificationXref76
cellular location: cytosol
comment: Reactome DB_ID: 73473

UnificationXref25
type: UnificationXref
id: REACT_150379
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150379.1

15k-PGF2a
type: SmallMolecule
entity reference: 15-Keto-PGF2a
data source: Reactome
xref: UnificationXref70
xref: UnificationXref71
cellular location: cytosol
comment: Reactome DB_ID: 2142799

UnificationXref24
type: UnificationXref
id: 2161896
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161896

UnificationXref27
type: UnificationXref
id: P19941
db: UniProt

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: Guanosine 5'-triphosphate
data source: Reactome
xref: UnificationXref149
xref: UnificationXref148
cellular location: cytosol
comment: Reactome DB_ID: 29438
display name: GTP

proton
type: SmallMolecule
entity reference: H+ [ChEBI:15378]
data source: Reactome
xref: UnificationXref78
xref: UnificationXref79
cellular location: cytosol
comment: Reactome DB_ID: 70106
display name: H+

UnificationXref26
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

RelationshipXref1
type: RelationshipXref
id: GO:0004602
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref2
type: RelationshipXref
id: 2161894
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161894

RelationshipXref3
type: RelationshipXref
id: GO:0016301
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

RelationshipXref4
type: RelationshipXref
id: 213300
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213300

SequenceSite52
type: SequenceSite
position status: EQUAL
sequence position: 41

SequenceSite51
type: SequenceSite
position status: EQUAL
sequence position: 36

SequenceSite50
type: SequenceSite
position status: EQUAL
sequence position: 41

SequenceSite59
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref169
type: UnificationXref
id: CHEBI:29152
db: ChEBI

SequenceSite58
type: SequenceSite
position status: EQUAL
sequence position: 418

UnificationXref168
type: UnificationXref
id: REACT_15677
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15677.1

SequenceSite57
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref167
type: UnificationXref
id: 379707
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379707

UnificationXref166
type: UnificationXref
id: CHEBI:29158
db: ChEBI

SequenceSite56
type: SequenceSite
position status: EQUAL
sequence position: 524

UnificationXref165
type: UnificationXref
id: REACT_15840
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15840.1

SequenceSite55
type: SequenceSite
position status: EQUAL
sequence position: 213

UnificationXref164
type: UnificationXref
id: 379728
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379728

SequenceSite54
type: SequenceSite
position status: EQUAL
sequence position: 966

UnificationXref163
type: UnificationXref
id: CHEBI:29265
db: ChEBI

SequenceSite53
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref161
type: UnificationXref
id: 379720
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379720

UnificationXref162
type: UnificationXref
id: REACT_15727
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15727.1

UnificationXref160
type: UnificationXref
id: CHEBI:18366
db: ChEBI

SequenceSite61
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite60
type: SequenceSite
position status: EQUAL
sequence position: 353

SequenceSite63
type: SequenceSite
position status: EQUAL
sequence position: 176

SequenceSite62
type: SequenceSite
position status: EQUAL
sequence position: 212

UnificationXref10
type: UnificationXref
id: REACT_3495
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3495.2

UnificationXref12
type: UnificationXref
id: 29356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356

UnificationXref11
type: UnificationXref
id: CHEBI:15377
db: ChEBI

SequenceSite69
type: SequenceSite
position status: EQUAL
sequence position: 555

UnificationXref179
type: UnificationXref
id: 379784
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379784

http://identifiers.org/pubmed/3141418
type: PublicationXref
id: 3141418
author: RansnÃ¤s, LA
author: Insel, PA
db: Pubmed
title: Subunit dissociation is the mechanism for hormonal activation of the Gs protein in native membranes
source: J Biol Chem 263:17239-42
year: 1988

5-HETE
type: SmallMoleculeReference
name: 5-Hydroxyeicosatetraenoate
name: 5-Hydroxyeicosatetraenoate [ChEBI:2068]
xref: UnificationXref14

SequenceSite68
type: SequenceSite
position status: EQUAL
sequence position: 20

UnificationXref178
type: UnificationXref
id: CHEBI:29156
db: ChEBI

SequenceSite65
type: SequenceSite
position status: EQUAL
sequence position: 29

UnificationXref175
type: UnificationXref
id: CHEBI:29157
db: ChEBI

SequenceSite64
type: SequenceSite
position status: EQUAL
sequence position: 277

UnificationXref174
type: UnificationXref
id: REACT_15566
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15566.1

SequenceSite67
type: SequenceSite
position status: EQUAL
sequence position: 555

UnificationXref177
type: UnificationXref
id: REACT_16052
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16052.1

SequenceSite66
type: SequenceSite
position status: EQUAL
sequence position: 175

UnificationXref176
type: UnificationXref
id: 379751
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379751

UnificationXref170
type: UnificationXref
id: 379719
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379719

UnificationXref171
type: UnificationXref
id: REACT_15780
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15780.1

UnificationXref172
type: UnificationXref
id: CHEBI:29166
db: ChEBI

UnificationXref173
type: UnificationXref
id: 379772
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379772

ANPEP
type: ProteinReference
name: UniProt:P15541 ANPEP
xref: UnificationXref138
comment: CATALYTIC ACTIVITY Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.SIMILARITY Belongs to the peptidase M1 family.
organism: Oryctolagus cuniculus

guanine nucleotide-binding protein Gs alpha2
type: ProteinReference
name: PRF:2003375B guanine nucleotide-binding protein Gs alpha2
xref: UnificationXref255
organism: Oryctolagus cuniculus

UnificationXref289
type: UnificationXref
id: REACT_3225
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3225.1

UnificationXref288
type: UnificationXref
id: 109276
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109276

UnificationXref287
type: UnificationXref
id: REACT_13466
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13466.1

SequenceSite30
type: SequenceSite
position status: EQUAL
sequence position: 76

UnificationXref286
type: UnificationXref
id: 211643
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211643

UnificationXref285
type: UnificationXref
id: REACT_2467
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2467.2

UnificationXref284
type: UnificationXref
id: 141647
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=141647

UnificationXref188
type: UnificationXref
id: 379757
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379757

SequenceSite34
type: SequenceSite
position status: EQUAL
sequence position: 228

UnificationXref187
type: UnificationXref
id: CHEBI:16624
db: ChEBI

SequenceSite33
type: SequenceSite
position status: EQUAL
sequence position: 153

UnificationXref186
type: UnificationXref
id: REACT_17273
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17273.1

SequenceSite32
type: SequenceSite
position status: EQUAL
sequence position: 152

UnificationXref185
type: UnificationXref
id: 379787
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379787

SequenceSite31
type: SequenceSite
position status: EQUAL
sequence position: 77

SequenceSite38
type: SequenceSite
position status: EQUAL
sequence position: 380

SequenceSite37
type: SequenceSite
position status: EQUAL
sequence position: 305

SequenceSite36
type: SequenceSite
position status: EQUAL
sequence position: 304

UnificationXref189
type: UnificationXref
id: REACT_17915
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17915.1

SequenceSite35
type: SequenceSite
position status: EQUAL
sequence position: 229

UnificationXref180
type: UnificationXref
id: REACT_18164
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18164.1

SequenceSite39
type: SequenceSite
position status: EQUAL
sequence position: 381

UnificationXref183
type: UnificationXref
id: REACT_17784
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17784.1

UnificationXref184
type: UnificationXref
id: CHEBI:29160
db: ChEBI

UnificationXref181
type: UnificationXref
id: CHEBI:29155
db: ChEBI

UnificationXref182
type: UnificationXref
id: 379786
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379786

UnificationXref282
type: UnificationXref
id: 141644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=141644

UnificationXref283
type: UnificationXref
id: REACT_4142
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4142.2

UnificationXref280
type: UnificationXref
id: 141646
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=141646

UnificationXref281
type: UnificationXref
id: REACT_3557
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3557.2

http://identifiers.org/pubmed/12853446
type: PublicationXref
id: 12853446
author: McCarthy, CC
author: Stringer, DK
author: Koeppel, MA
author: Jakobi, R
db: Pubmed
title: Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation
source: J Biol Chem 278:38675-85
year: 2003

http://identifiers.org/pubmed/19754430
type: PublicationXref
id: 19754430
author: Komander, David
db: Pubmed
title: The emerging complexity of protein ubiquitination
source: Biochem. Soc. Trans. 37:937-53
year: 2009

UnificationXref299
type: UnificationXref
id: REACT_9589
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9589.1

gamma-L-Glutamyl-L-cysteinyl-glycine
type: SmallMoleculeReference
name: 5-L-Glutamyl-L-cysteinylglycine
name: N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine
name: Reduced glutathione
name: Glutathione
name: GSH
name: Glutathione [ChEBI:16856]
xref: UnificationXref5

O-phospho-L-threonine
type: SequenceModificationVocabulary
xref: UnificationXref87

UnificationXref296
type: UnificationXref
id: P19813
db: UniProt

O-phospho-L-serine
type: SequenceModificationVocabulary
xref: UnificationXref41

UnificationXref295
type: UnificationXref
id: REACT_4078
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4078.3

UnificationXref298
type: UnificationXref
id: 189113
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189113

SequenceSite41
type: SequenceSite
position status: EQUAL
sequence position: 457

UnificationXref297
type: UnificationXref
id: MOD:00171
db: MOD

SequenceSite40
type: SequenceSite
position status: EQUAL
sequence position: 456

UnificationXref197
type: UnificationXref
id: 379792
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379792

SequenceSite43
type: SequenceSite
position status: EQUAL
sequence position: 533

UnificationXref196
type: UnificationXref
id: CHEBI:29153
db: ChEBI

SequenceSite42
type: SequenceSite
position status: EQUAL
sequence position: 532

UnificationXref199
type: UnificationXref
id: CHEBI:29154
db: ChEBI

SequenceSite45
type: SequenceSite
position status: EQUAL
sequence position: 609

UnificationXref198
type: UnificationXref
id: REACT_15573
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15573.1

SequenceSite44
type: SequenceSite
position status: EQUAL
sequence position: 608

SequenceSite47
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite46
type: SequenceSite
position status: EQUAL
sequence position: 684

SequenceSite49
type: SequenceSite
position status: EQUAL
sequence position: 35

SequenceSite48
type: SequenceSite
position status: EQUAL
sequence position: 524

UnificationXref190
type: UnificationXref
id: CHEBI:16047
db: ChEBI

UnificationXref191
type: UnificationXref
id: 379736
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379736

UnificationXref192
type: UnificationXref
id: REACT_15620
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15620.1

UnificationXref193
type: UnificationXref
id: CHEBI:16635
db: ChEBI

UnificationXref194
type: UnificationXref
id: 379794
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379794

UnificationXref195
type: UnificationXref
id: REACT_18004
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18004.1

UnificationXref291
type: UnificationXref
id: 189078
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189078

UnificationXref292
type: UnificationXref
id: REACT_9619
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9619.1

UnificationXref293
type: UnificationXref
id: CHEBI:17925
db: ChEBI

UnificationXref294
type: UnificationXref
id: 70115
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70115

UnificationXref290
type: UnificationXref
id: CHEBI:16551
db: ChEBI

phospho-PAK-2p34 (Thr 402)
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref240
xref: UnificationXref239
feature: ModificationFeature6
cellular location: nucleoplasm
comment: Reactome DB_ID: 266149

ADRB2_MOUSE
type: Protein
entity reference: UniProt:P18762 Adrb2
data source: Reactome
name: Beta-2 adrenergic receptor
xref: UnificationXref248
xref: UnificationXref249
feature: FragmentFeature26
cellular location: plasma membrane
comment: Reactome DB_ID: 421951
display name: Adrb2

CDC42-GTP
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry28
component stoichiometry: Stoichiometry27
component: Guanosine 5'-triphosphate
component: Cdc42
xref: UnificationXref305
xref: UnificationXref306
cellular location: cytosol
comment: Reactome DB_ID: 213299

active caspase-3
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry25
component stoichiometry: Stoichiometry24
component: Caspase-3 (small subunit)
component: Caspase-3 (large subunit)
xref: UnificationXref285
xref: UnificationXref284
cellular location: cytosol
comment: Reactome DB_ID: 141647

G-protein beta:gamma complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry21
component stoichiometry: Stoichiometry20
component: G-protein beta subunit
component: Guanine nucleotide-binding protein subunit gamma-2
xref: UnificationXref269
xref: UnificationXref270
cellular location: plasma membrane
comment: Reactome DB_ID: 421950

ChEBI:17732 Ala-tRNA(Ala)
type: SmallMoleculeReference
name: Ala-tRNA(Ala)
xref: UnificationXref157

80S:Met-tRNAi:mRNA:aa-tRNA
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry33
component stoichiometry: Stoichiometry34
component: 80S:Met-tRNAi:mRNA
component: Aminoacyl-tRNA
xref: UnificationXref316
xref: UnificationXref317
cellular location: cytosol
comment: Reactome DB_ID: 159890

UnificationXref9
type: UnificationXref
id: 111745
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111745

UnificationXref8
type: UnificationXref
id: CHEBI:17858
db: ChEBI

ChEBI:16635 Met-tRNA(Met)
type: SmallMoleculeReference
name: Met-tRNA(Met)
xref: UnificationXref193

Inactive Pak2:Cdc42-GTP complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry30
component stoichiometry: Stoichiometry29
component: CDC42-GTP
component: partially auto-phosphorylated PAK-2 (inactive)
xref: UnificationXref307
xref: UnificationXref308
cellular location: cytosol
comment: Reactome DB_ID: 213298

UnificationXref7
type: UnificationXref
id: REACT_3050
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3050.2

reEF1A:GDP
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry32
component stoichiometry: Stoichiometry31
component: reEF1A
component: Guanosine 5'-diphosphate
xref: UnificationXref315
xref: UnificationXref314
cellular location: cytosol
comment: Reactome DB_ID: 159625

phospho-PAK-2p34 (Thr 402)
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref237
xref: UnificationXref236
feature: ModificationFeature6
cellular location: cytosol
comment: Reactome DB_ID: 266144

UnificationXref6
type: UnificationXref
id: 29450
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29450

reEF1A
type: Protein
entity reference: EEF1A1
data source: Reactome
xref: UnificationXref152
xref: UnificationXref151
cellular location: cytosol
comment: Reactome DB_ID: 159543

UnificationXref5
type: UnificationXref
id: CHEBI:16856
db: ChEBI

UnificationXref4
type: UnificationXref
id: REACT_15596
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15596.2

PAK-2p34
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref144
xref: UnificationXref143
feature: FragmentFeature25
cellular location: cytosol
comment: Reactome DB_ID: 211637

UnificationXref3
type: UnificationXref
id: 266010
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266010

AMPN_RABIT
type: Protein
entity reference: ANPEP
data source: Reactome
xref: UnificationXref140
xref: UnificationXref139
feature: FragmentFeature24
cellular location: plasma membrane
comment: Reactome DB_ID: 2022347
display name: ANPEP

UnificationXref2
type: UnificationXref
id: CHEBI:15632
db: ChEBI

Angiotensin-(3-8)
type: Protein
entity reference: SERPINA8
data source: Reactome
name: ANGT_HUMAN
name: ANG3-8
name: Angiotensin IV
name: AGT(36-41)
xref: UnificationXref136
xref: UnificationXref137
feature: FragmentFeature23
cellular location: extracellular region
comment: Reactome DB_ID: 2022355
display name: AGT

UnificationXref1
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

ANG2-8
type: Protein
entity reference: SERPINA8
data source: Reactome
name: AGT(35-41)
name: ANGT_HUMAN
name: Angiotensin-(2-8)
name: Angiotensin III
xref: UnificationXref135
xref: UnificationXref134
feature: FragmentFeature22
cellular location: extracellular region
comment: Reactome DB_ID: 2022354
display name: AGT

K48polyUb-phospho-PAK-2p34(Thr 402)
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref127
xref: UnificationXref126
feature: ModificationFeature6
feature: FragmentFeature21
feature: ModificationFeature7
cellular location: cytosol
comment: Reactome DB_ID: 3095872

ubiquitin (UBC 9)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref122
xref: UnificationXref121
feature: FragmentFeature20
cellular location: cytosol
comment: Reactome DB_ID: 939165
display name: UBC(609-684)

ubiquitin (UBC 8)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref120
xref: UnificationXref119
feature: FragmentFeature19
cellular location: cytosol
comment: Reactome DB_ID: 939239
display name: UBC(533-608)

trehalase
type: Protein
entity reference: TREA
data source: Reactome
xref: UnificationXref298
xref: UnificationXref299
feature: ModificationFeature8
feature: FragmentFeature31
cellular location: plasma membrane
comment: Reactome DB_ID: 189113

Cdc42
type: Protein
entity reference: UniProt:Q5U814 Small GTP binding protein CDC42
data source: Reactome
xref: UnificationXref304
xref: UnificationXref303
cellular location: cytosol
comment: Reactome DB_ID: 213296

http://identifiers.org/pubmed/6466686
type: PublicationXref
id: 6466686
author: Galand, G
db: Pubmed
title: Purification and characterization of kidney and intestinal brush-border membrane trehalases from the rabbit
source: Biochim Biophys Acta 789:10-9
year: 1984

UBC
type: ProteinReference
name: UniProt:P0CG48 UBC
xref: UnificationXref104
comment: FUNCTION Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.SIMILARITY Belongs to the ubiquitin family.SIMILARITY Contains 9 ubiquitin-like domains.
organism: Homo sapiens

UniProt:P0CG47 UBB
type: ProteinReference
name: UBB
xref: UnificationXref97
comment: FUNCTION Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS The mRNA encoding variant UBB(+1) is produced by an unknown mechanism involving the deletion of a GT dinucleotide in the close proximity of a GAGAG motif (PubMed:9422699). This variant mRNA is found in normal brain, but the encoded protein accumulates only in brain …
organism: Homo sapiens

Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197
type: BiochemicalReaction
data source: Reactome
xref: http://identifiers.org/pubmed/10075701
xref: UnificationXref48
xref: http://identifiers.org/pubmed/16204230
xref: UnificationXref47
participant stoichiometry: Stoichiometry3
participant stoichiometry: Stoichiometry4
left: PAK-2
left: Adenosine 5'-triphosphate
comment: Edited: Matthews, L, 2008-05-28 22:54:51
comment: Reviewed: Chang, E, 2008-05-21 00:05:41
comment: Edited: Matthews, L, 2008-02-08 00:29:01
comment: Authored: Jakobi, R, 2008-02-05 11:04:14
comment: Inactive PAK-2 can be partially autophosphorylated in the regulatory region without being activated (Gatti et al. 1999).
right: Adenosine 5'-diphosphate
right: partially auto-phosphorylated PAK-2 (inactive)

PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD
type: BiochemicalReaction
data source: Reactome
EC number: 1.1.1.141
xref: UnificationXref85
xref: UnificationXref86
xref: http://identifiers.org/pubmed/3954355
left: DPN
left: PGD2/E2/F2a
comment: Authored: Williams, MG, 2012-02-24
comment: Edited: Williams, MG, 2012-02-24
comment: Reviewed: Rush, MG, 2012-11-10
comment: In rabbits, 15-hydroxyprostaglandin dehydrogenase (HPGD) oxidises prostaglandins D2 (PGD2), E2 (PGE2), and F2alpha (PGF2a) to 15-keto-prostaglandin D2 (15k-PGD2), E2 (15k-PGE2), and F2alpha (15k-PGF2a) respectively (Bergholte & Okita 1986).
right: NADH
right: proton
right: 15k-PGD2/E2/F2a

5S-HpETE is reduced to 5S-HETE by GPX1
type: BiochemicalReaction
data source: Reactome
EC number: 1.11.1.9
xref: UnificationXref25
xref: UnificationXref24
xref: http://identifiers.org/pubmed/10549853
participant stoichiometry: Stoichiometry1
left: gamma-L-Glutamyl-L-cysteinyl-glycine
left: (S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
comment: Authored: Williams, MG, 2012-02-24
comment: Edited: Williams, MG, 2012-02-24
comment: Reviewed: Rush, MG, 2012-11-10
comment: The cytosol of rabbit lung alveolar macrophages contains a high amount of glutathione peroxidase 1 (GPX1), which reduces 5-hydroperoxyeicosatetraenoic acid (5-HPETE) to 5-hydroxyeicosatetraenoic acid (5-HETE) in the presence of glutathione (GSH) (Chiba et al. 1999). Current literature suggests that 5-HETE itself does not appear to play a significant role in biological signalling. However, it can be further oxidised by a 5-hydroxy-eicosatetraenoic acid dehydrogenase (5-HEDH) to form the bioactive 5-oxo-eicosatetraenoic acid (5-oxoETE) aka 5-KETE.
right: glutathione disulfide
right: 5S-HETE
right: Water

Ghr internalization
type: BiochemicalReaction
data source: Reactome
xref: http://identifiers.org/pubmed/17488973
xref: UnificationXref33
xref: UnificationXref34
left: Growth hormone receptor
comment: Reviewed: Herington, AC, 2011-06-13
comment: Cell surface levels of GHR are the primary determinant of GH responsiveness. This is modulated partly by endocytosis and lysosomal degradation. This downregulation is strongly inhibited by the association of JAK2 with the receptor, and by GH if JAK2 is prevented from signaling, but markedly enhanced by GH if JAK2 is kinase active. GH down-regulation also requires GHR tyrosine phosphorylation (Deng et al. 2007) and is believed to be mediated by GHR ubiquitination and proteasomal degradation.
comment: Reviewed: Waters, MJ, 2011-06-23
comment: Authored: Jupe, S, 2010-10-14
comment: Edited: Jupe, S, 2011-06-10

ChEBI:16624 Leu-tRNA(Leu)
type: SmallMoleculeReference
name: Leu-tRNA(Leu)
xref: UnificationXref187

Autophosphorylation of PAK-2p34
type: BiochemicalReaction
data source: Reactome
xref: UnificationXref145
xref: http://identifiers.org/pubmed/9786869
xref: UnificationXref146
left: Adenosine 5'-triphosphate
left: PAK-2p34
comment: Edited: Matthews, L, 2008-05-23 07:02:49
comment: Edited: Matthews, L, 2008-02-06 20:56:00
comment: Reviewed: Chang, E, 2008-05-21 00:05:41
comment: Authored: Jakobi, R, 2008-02-05 11:04:14
comment: Activation of PAK-2p34 coincides with autophosphorylation of Thr 402 in the the catalytic domain (Walter et al., 1998).
right: Adenosine 5'-diphosphate
right: phospho-PAK-2p34(Thr 402)

reEF1A complexes with GTP
type: BiochemicalReaction
data source: Reactome
xref: UnificationXref155
xref: http://identifiers.org/pubmed/6568109
xref: UnificationXref156
left: Guanosine 5'-triphosphate
left: reEF1A
comment: At the beginning of this reaction, 1 molecule of 'GTP', and 1 molecule of 'reEF1A' are present. At the end of this reaction, 1 molecule of 'reEF1A:GTP' is present. This reaction is mediated by the 'guanyl nucleotide binding activity' of 'reEF1A'.
right: reEF1A:GTP

Ubiquitination of PAK-2p34
type: BiochemicalReaction
data source: Reactome
EC number: 6.3.2.19
xref: http://identifiers.org/pubmed/12853446
xref: UnificationXref131
xref: UnificationXref130
xref: http://identifiers.org/pubmed/19754430
left: ubiquitin
left: phospho-PAK-2p34(Thr 402)
comment: PAK-2p34 is ubiquitinated prior to degradation (Jakobi et al., 2003). Here, ubiquitination of PAK-2p34 is described as occurring in the cytosol. However, to date it is not known whether this occurs in the nucleus or in the cytoplasm. Evidence for this reaction comes from experiments using both human and rabbit proteins. The polyubiquitin synthesized in the reaction is inferred to contain lysine-48 (K48) linkages because the modified protein is targeted to the proteasome (Komander 2009).
comment: Edited: Matthews, L, 2008-05-23 07:17:49
comment: Reviewed: Chang, E, 2008-05-21 00:05:41
comment: Edited: Matthews, L, 2008-02-03 20:50:13
comment: Authored: Jakobi, R, 2008-02-05 11:04:14
right: K48polyUb-phospho-PAK-2p34(Thr 402)

ANPEP Hydrolyzes Angiotensin III to Yield Angiotensin IV
type: BiochemicalReaction
data source: Reactome
xref: http://identifiers.org/pubmed/1978675
xref: UnificationXref142
xref: UnificationXref141
left: ANG2-8
comment: ANPEP from rabbit renal membranes hydrolyzes angiotensin III to yield angiotensin IV.
comment: Authored: May, B, 2011-11-29
comment: Edited: May, B, 2011-11-29
comment: Reviewed: Joseph, J, 2012-08-06
right: Angiotensin-(3-8)

Auto-phosphorylated PAK-2 (p27 regulatory fragment)
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref278
xref: UnificationXref277
feature: ModificationFeature2
feature: ModificationFeature5
feature: ModificationFeature1
feature: ModificationFeature4
feature: FragmentFeature28
feature: ModificationFeature3
cellular location: cytosol
comment: Reactome DB_ID: 213022

GBB5_RABIT
type: Protein
entity reference: GNB5
data source: Reactome
name: Guanine nucleotide-binding protein subunit beta-5
xref: UnificationXref264
xref: UnificationXref263
feature: FragmentFeature27
cellular location: plasma membrane
comment: Reactome DB_ID: 421942
display name: GNB5

Caspase-3 (large subunit)
type: Protein
entity reference: CASP3
data source: Reactome
name: CASP3(29-175)
xref: UnificationXref282
xref: UnificationXref283
feature: FragmentFeature30
cellular location: cytosol
comment: Reactome DB_ID: 141644
display name: CASP3

reEF1A:GTP:Aminoacyl-tRNA ternary complex formation
type: BiochemicalReaction
data source: Reactome
xref: UnificationXref222
xref: http://identifiers.org/pubmed/6568109
xref: UnificationXref221
left: reEF1A:GTP
left: Aminoacyl-tRNA
comment: At the beginning of this reaction, 1 molecule of 'Aminoacyl-tRNA', and 1 molecule of 'reEF1A:GTP' are present. At the end of this reaction, 1 molecule of 'reEF1A:GTP:Aminoacyl-tRNA complex' is present.
right: reEF1A:GTP:Aminoacyl-tRNA complex

Caspase-3 (small subunit)
type: Protein
entity reference: CASP3
data source: Reactome
xref: UnificationXref280
xref: UnificationXref281
feature: FragmentFeature29
cellular location: cytosol
comment: Reactome DB_ID: 141646
display name: CASP3(176-277)

Q6X973_RABIT
type: Protein
entity reference: Guanine nucleotide-binding protein Gs alpha1
data source: Reactome
xref: UnificationXref253
xref: UnificationXref254
cellular location: plasma membrane
comment: Reactome DB_ID: 421934
display name: G(s) alpha 1

G(s) alpha subunit
type: Protein
data source: Reactome
member physical entity: Q6X973_RABIT
member physical entity: G(s) alpha 2
xref: UnificationXref259
xref: UnificationXref258
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 421937

G-protein beta subunit
type: Protein
data source: Reactome
member physical entity: GBB5_RABIT
xref: UnificationXref266
xref: UnificationXref265
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 421945

G(s) alpha 2
type: Protein
entity reference: guanine nucleotide-binding protein Gs alpha2
data source: Reactome
xref: UnificationXref256
xref: UnificationXref257
cellular location: plasma membrane
comment: Reactome DB_ID: 421933

Guanine nucleotide-binding protein subunit gamma-2
type: PhysicalEntity
data source: Reactome
xref: UnificationXref268
xref: UnificationXref267
cellular location: plasma membrane
comment: Reactome DB_ID: 421948

http://identifiers.org/pubmed/9786869
type: PublicationXref
id: 9786869
author: Traugh, JA
author: Huang, Z
author: Walter, BN
author: Tuazon, PT
author: Litwack, G
author: Alnemri, ES
author: Jakobi, R
db: Pubmed
title: Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity
source: J Biol Chem 273:28733-9
year: 1998

Reactome
type: Provenance
comment: http://www.reactome.org

fMet-tRNA
type: PhysicalEntity
data source: Reactome
name: methionyl initiator tRNA
name: Met-tRNAf
xref: UnificationXref224
xref: UnificationXref223
cellular location: cytosol
display name: Met-tRNAi
comment: Reactome DB_ID: 72393

80S ribosome
type: PhysicalEntity
data source: Reactome
xref: UnificationXref228
xref: UnificationXref229
cellular location: cytosol
comment: Reactome DB_ID: 159892

Ubiquitin ligase
type: PhysicalEntity
data source: Reactome
xref: UnificationXref129
xref: UnificationXref128
cellular location: cytosol
comment: Reactome DB_ID: 69593

messenger RNA [ChEBI:33699]
type: SmallMoleculeReference
name: messenger RNA
name: template RNA
name: mRNA
xref: UnificationXref225

http://identifiers.org/pubmed/1697585
type: PublicationXref
id: 1697585
author: Wacker, H
author: Galand, G
author: Mantei, N
author: Ruf, J
author: von Kieckebusch, A
author: James, P
author: Maffia, M
author: Seiler, P
author: Semenza, G
db: Pubmed
title: Rabbit small intestinal trehalase. Purification, cDNA cloning, expression, and verification of glycosylphosphatidylinositol anchoring.
source: J Biol Chem 265:15034-9
year: 1990

ubiquitin (UBC 7)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref118
xref: UnificationXref117
feature: FragmentFeature18
cellular location: cytosol
comment: Reactome DB_ID: 939184
display name: UBC(457-532)

http://identifiers.org/pubmed/9427547
type: PublicationXref
id: 9427547
author: Taketani, S
author: Tokunaga, R
author: Kino, M
author: Kobayashi, Y
author: Ishihara, R
author: Sasai-Takedatsu, M
db: Pubmed
title: Molecular cloning, sequencing and expression of cDNA encoding human trehalase
source: Gene 202:69-74
year: 1997

ubiquitin (UBC 6)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref116
xref: UnificationXref115
feature: FragmentFeature17
cellular location: cytosol
comment: Reactome DB_ID: 939191
display name: UBC(381-456)

ubiquitin (UBC 5)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref114
xref: UnificationXref113
feature: FragmentFeature16
cellular location: cytosol
comment: Reactome DB_ID: 939232
display name: UBC(305-380)

UBB(1-76)
type: Protein
entity reference: UniProt:P0CG47 UBB
data source: Reactome
name: ubiquitin (UBB 1)
xref: UnificationXref99
xref: UnificationXref98
feature: FragmentFeature9
cellular location: cytosol
comment: Reactome DB_ID: 939214
display name: UBB

UBA52(1-76)
type: Protein
entity reference: UniProt:P62987 UBA52
data source: Reactome
name: ubiquitin (UBA52)
xref: UnificationXref95
xref: UnificationXref96
feature: FragmentFeature8
cellular location: cytosol
comment: Reactome DB_ID: 939203
display name: UBA52

ubiquitin (UBB 3)
type: Protein
entity reference: UniProt:P0CG47 UBB
data source: Reactome
xref: UnificationXref103
xref: UnificationXref102
feature: FragmentFeature11
cellular location: cytosol
comment: Reactome DB_ID: 939230
display name: UBB(153-228)

ubiquitin (UBB 2)
type: Protein
entity reference: UniProt:P0CG47 UBB
data source: Reactome
xref: UnificationXref101
xref: UnificationXref100
feature: FragmentFeature10
cellular location: cytosol
comment: Reactome DB_ID: 939213
display name: UBB(77-152)

ubiquitin (UBC 2)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref108
xref: UnificationXref107
feature: FragmentFeature13
cellular location: cytosol
comment: Reactome DB_ID: 939164
display name: UBC(77-152)

UBC(1-76)
type: Protein
entity reference: UBC
data source: Reactome
name: ubiquitin (UBC 1)
xref: UnificationXref105
xref: UnificationXref106
feature: FragmentFeature12
cellular location: cytosol
comment: Reactome DB_ID: 939188
display name: UBC

ubiquitin (UBC 4)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref112
xref: UnificationXref111
feature: FragmentFeature15
cellular location: cytosol
comment: Reactome DB_ID: 939192
display name: UBC(229-304)

ubiquitin (UBC 3)
type: Protein
entity reference: UBC
data source: Reactome
xref: UnificationXref110
xref: UnificationXref109
feature: FragmentFeature14
cellular location: cytosol
comment: Reactome DB_ID: 939258
display name: UBC(153-228)

RPS27A(1-76)
type: Protein
entity reference: UBA80
data source: Reactome
name: ubiquitin (RPS27A)
xref: UnificationXref93
xref: UnificationXref92
feature: FragmentFeature7
cellular location: cytosol
comment: Reactome DB_ID: 939205
display name: RPS27A

PAK2
type: ProteinReference
name: UniProt:Q29502 PAK2
xref: UnificationXref35
comment: CATALYTIC ACTIVITY ATP + a protein = ADP + a phosphoprotein.SIMILARITY Contains 1 CRIB domain.SIMILARITY Contains 1 protein kinase domain.
organism: Oryctolagus cuniculus

UnificationXref79
type: UnificationXref
id: REACT_4941
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4941.2

partially auto-phosphorylated PAK-2 (inactive)
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref43
xref: UnificationXref42
feature: ModificationFeature2
feature: ModificationFeature5
feature: ModificationFeature1
feature: ModificationFeature4
feature: FragmentFeature5
feature: ModificationFeature3
cellular location: cytosol
comment: Reactome DB_ID: 213304

G1TBB5_RABIT
type: Protein
entity reference: UniProt:G1TBB5
data source: Reactome
xref: UnificationXref82
xref: UnificationXref81
cellular location: cytosol
comment: Reactome DB_ID: 2142728
display name: HPGD

phospho-PAK-2p34(Thr 402)
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref89
xref: UnificationXref88
feature: ModificationFeature6
feature: FragmentFeature6
cellular location: cytosol
comment: Reactome DB_ID: 211641

ubiquitin
type: Protein
data source: Reactome
member physical entity: ubiquitin (UBC 4)
member physical entity: UBC(1-76)
member physical entity: ubiquitin (UBC 7)
member physical entity: UBA52(1-76)
member physical entity: ubiquitin (UBC 5)
member physical entity: ubiquitin (UBC 6)
member physical entity: ubiquitin (UBC 8)
member physical entity: ubiquitin (UBB 2)
member physical entity: RPS27A(1-76)
member physical entity: ubiquitin (UBC 2)
member physical entity: ubiquitin (UBC 9)
member physical entity: ubiquitin (UBB 3)
member physical entity: ubiquitin (UBC 3)
member physical entity: UBB(1-76)
xref: UnificationXref124
xref: UnificationXref123
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 113595
display name: Ub

GPX1_RABIT
type: Protein
entity reference: UniProt:P11909 GPX1
data source: Reactome
xref: UnificationXref20
xref: UnificationXref19
feature: FragmentFeature1
cellular location: cytosol
comment: Reactome DB_ID: 2142684
display name: GPX1

Growth hormone receptor
type: Protein
entity reference: UniProt:P19941 GHR
data source: Reactome
xref: UnificationXref29
xref: UnificationXref28
feature: FragmentFeature2
cellular location: plasma membrane
comment: Reactome DB_ID: 1169260
display name: GHR

Growth hormone receptor
type: Protein
entity reference: UniProt:P19941 GHR
data source: Reactome
xref: UnificationXref31
xref: UnificationXref32
feature: FragmentFeature3
cellular location: endosome lumen
comment: Reactome DB_ID: 1169266
display name: GHR

PAK-2
type: Protein
entity reference: PAK2
data source: Reactome
xref: UnificationXref36
xref: UnificationXref37
feature: FragmentFeature4
cellular location: cytosol
comment: Reactome DB_ID: 211648

Isoprotenerol
type: SmallMolecule
entity reference: ISUPREL (TN)
data source: Reactome
xref: UnificationXref244
xref: UnificationXref245
cellular location: extracellular region
comment: Reactome DB_ID: 421954
display name: ISPOL

UnificationXref83
type: UnificationXref
id: 2142782
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142782

messenger RNA
type: SmallMolecule
entity reference: messenger RNA [ChEBI:33699]
data source: Reactome
xref: UnificationXref227
xref: UnificationXref226
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 162612
display name: mRNA

UnificationXref82
type: UnificationXref
id: REACT_152148
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152148.1

water
type: SmallMolecule
entity reference: H2O
data source: Reactome
xref: UnificationXref289
xref: UnificationXref288
cellular location: extracellular region
comment: Reactome DB_ID: 109276
display name: H2O

UnificationXref85
type: UnificationXref
id: 2161568
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161568

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: Guanosine 5'-triphosphate
data source: Reactome
xref: UnificationXref250
xref: UnificationXref251
cellular location: plasma membrane
comment: Reactome DB_ID: 113572
display name: GTP

UnificationXref84
type: UnificationXref
id: REACT_152255
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152255.1

alpha-D-glucose
type: SmallMolecule
entity reference: alpha-D-Glucose [ChEBI:17925]
data source: Reactome
xref: UnificationXref294
xref: UnificationXref295
cellular location: extracellular region
comment: Reactome DB_ID: 70115
display name: Glc

UnificationXref87
type: UnificationXref
id: MOD:00047
db: MOD

alpha,alpha-trehalose
type: SmallMolecule
entity reference: alpha,alpha-Trehalose
data source: Reactome
xref: UnificationXref292
xref: UnificationXref291
cellular location: extracellular region
comment: Reactome DB_ID: 189078

UnificationXref86
type: UnificationXref
id: REACT_150263
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150263.1

Phosphate
type: SmallMolecule
entity reference: Phosphate
data source: Reactome
name: Orthophosphate
name: Inorganic Phosphate
xref: UnificationXref319
xref: UnificationXref320
cellular location: cytosol
comment: Reactome DB_ID: 29372
display name: Pi

UnificationXref89
type: UnificationXref
id: REACT_14018
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14018.1

Guanosine 5'-diphosphate
type: SmallMolecule
entity reference: Guanosine 5'-diphosphate
data source: Reactome
name: Guanosine diphosphate
xref: UnificationXref313
xref: UnificationXref312
cellular location: cytosol
comment: Reactome DB_ID: 29420
display name: GDP

UnificationXref88
type: UnificationXref
id: 211641
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211641

5-HPETE
type: SmallMoleculeReference
name: 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
name: 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate [ChEBI:2061]
name: (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
xref: UnificationXref2

Val-tRNA(Val)
type: SmallMolecule
entity reference: Val-tRNA(Val)
data source: Reactome
xref: UnificationXref216
xref: UnificationXref215
cellular location: cytosol
comment: Reactome DB_ID: 379790

UnificationXref81
type: UnificationXref
id: 2142728
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142728

UnificationXref80
type: UnificationXref
id: G1TBB5
db: UniProt

gene ontology term for cellular function
type: RelationshipTypeVocabulary
xref: UnificationXref23

Trp-tRNA(Trp)
type: SmallMolecule
entity reference: ChEBI:29159 Trp-tRNA(Trp)
data source: Reactome
xref: UnificationXref210
xref: UnificationXref209
cellular location: cytosol
comment: Reactome DB_ID: 379765

Tyr-tRNA(Tyr)
type: SmallMolecule
entity reference: Tyr-tRNA(Tyr)
data source: Reactome
xref: UnificationXref213
xref: UnificationXref212
cellular location: cytosol
comment: Reactome DB_ID: 379785

(5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate
type: SmallMoleculeReference
name: (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate [ChEBI:247]
xref: UnificationXref66

Met-tRNA(Met)
type: SmallMolecule
entity reference: ChEBI:16635 Met-tRNA(Met)
data source: Reactome
xref: UnificationXref195
xref: UnificationXref194
cellular location: cytosol
comment: Reactome DB_ID: 379794

UnificationXref96
type: UnificationXref
id: REACT_24649
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24649.2

Lys-tRNA(Lys)
type: SmallMolecule
entity reference: ChEBI:16047 Lys-tRNA(Lys)
data source: Reactome
xref: UnificationXref192
xref: UnificationXref191
cellular location: cytosol
comment: Reactome DB_ID: 379736

UnificationXref95
type: UnificationXref
id: 939203
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939203

Leu-tRNA(Leu)
type: SmallMolecule
entity reference: ChEBI:16624 Leu-tRNA(Leu)
data source: Reactome
xref: UnificationXref188
xref: UnificationXref189
cellular location: cytosol
comment: Reactome DB_ID: 379757

UnificationXref94
type: UnificationXref
id: P62987
db: UniProt

Ile-tRNA(Ile)
type: SmallMolecule
entity reference: Ile-tRNA(Ile)
data source: Reactome
xref: UnificationXref185
xref: UnificationXref186
cellular location: cytosol
comment: Reactome DB_ID: 379787

UnificationXref93
type: UnificationXref
id: REACT_24666
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24666.2

Thr-tRNA(Thr)
type: SmallMolecule
entity reference: Thr-tRNA(Thr)
data source: Reactome
xref: UnificationXref206
xref: UnificationXref207
cellular location: cytosol
comment: Reactome DB_ID: 379783

Stoichiometry1
type: Stoichiometry
physical entity: gamma-L-Glutamyl-L-cysteinyl-glycine
stoichiometric coefficient: 2.0

Ser-tRNA(Ser)
type: SmallMolecule
entity reference: Ser-tRNA(Ser)
data source: Reactome
xref: UnificationXref203
xref: UnificationXref204
cellular location: cytosol
comment: Reactome DB_ID: 379738

Stoichiometry2
type: Stoichiometry
physical entity: GPX1_RABIT
stoichiometric coefficient: 4.0

UnificationXref99
type: UnificationXref
id: REACT_24747
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24747.2

Pro-tRNA(Pro)
type: SmallMolecule
entity reference: Pro-tRNA(Pro)
data source: Reactome
xref: UnificationXref201
xref: UnificationXref200
cellular location: cytosol
comment: Reactome DB_ID: 379746

UnificationXref98
type: UnificationXref
id: 939214
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939214

Phe-tRNA(Phe)
type: SmallMolecule
entity reference: ChEBI:29153 Phe-tRNA(Phe)
data source: Reactome
xref: UnificationXref198
xref: UnificationXref197
cellular location: cytosol
comment: Reactome DB_ID: 379792

UnificationXref97
type: UnificationXref
id: P0CG47
db: UniProt

Stoichiometry5
type: Stoichiometry
physical entity: G1TBB5_RABIT
stoichiometric coefficient: 2.0

NAD
type: SmallMoleculeReference
name: NAD+ [ChEBI:15846]
name: DPN
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref49

Stoichiometry6
type: Stoichiometry
physical entity: Guanosine 5'-triphosphate
stoichiometric coefficient: 1.0

Stoichiometry3
type: Stoichiometry
physical entity: Adenosine 5'-triphosphate
stoichiometric coefficient: 5.0

Stoichiometry4
type: Stoichiometry
physical entity: Adenosine 5'-diphosphate
stoichiometric coefficient: 5.0

Stoichiometry9
type: Stoichiometry
physical entity: reEF1A:GTP
stoichiometric coefficient: 1.0

UnificationXref92
type: UnificationXref
id: 939205
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939205

UnificationXref91
type: UnificationXref
id: P62979
db: UniProt

Stoichiometry7
type: Stoichiometry
physical entity: reEF1A
stoichiometric coefficient: 1.0

UnificationXref90
type: UnificationXref
id: 9606
db: NCBI Taxonomy

Stoichiometry8
type: Stoichiometry
physical entity: Aminoacyl-tRNA
stoichiometric coefficient: 1.0

UnificationXref57
type: UnificationXref
id: REACT_15804
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15804.2

UnificationXref58
type: UnificationXref
id: CHEBI:15553
db: ChEBI

UnificationXref59
type: UnificationXref
id: 879535
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879535

RelationshipXref16
type: RelationshipXref
id: GO:0004555
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref65
type: UnificationXref
id: REACT_151260
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151260.1

RelationshipXref17
type: RelationshipXref
id: 189088
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189088

UnificationXref64
type: UnificationXref
id: 2142752
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142752

SequenceSite1
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref14
type: RelationshipXref
id: GO:0004197
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref67
type: UnificationXref
id: 2142721
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142721

http://identifiers.org/pubmed/16204230
type: PublicationXref
id: 16204230
author: Traugh, JA
author: Jung, JH
db: Pubmed
title: Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141
source: J Biol Chem 280:40025-31
year: 2005

RelationshipXref15
type: RelationshipXref
id: 114327
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114327

UnificationXref66
type: UnificationXref
id: CHEBI:15547
db: ChEBI

Glutathione disulfide
type: SmallMoleculeReference
name: Oxidized glutathione [ChEBI:17858]
name: GSSG
name: Oxidized glutathione
xref: UnificationXref8

UnificationXref61
type: UnificationXref
id: 2161661
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161661

UnificationXref60
type: UnificationXref
id: REACT_24606
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24606.2

NADH
type: SmallMoleculeReference
name: NADH [ChEBI:16908]
xref: UnificationXref74

RelationshipXref18
type: RelationshipXref
id: GO:0003924
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref63
type: UnificationXref
id: CHEBI:15557
db: ChEBI

RelationshipXref19
type: RelationshipXref
id: 159886
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159886

UnificationXref62
type: UnificationXref
id: REACT_150622
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150622.1

SequenceSite8
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite9
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite6
type: SequenceSite
position status: EQUAL
sequence position: 638

SequenceSite7
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref12
type: RelationshipXref
id: GO:0019001
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

SequenceSite4
type: SequenceSite
position status: EQUAL
sequence position: 638

RelationshipXref13
type: RelationshipXref
id: 159586
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159586

SequenceSite5
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite2
type: SequenceSite
position status: EQUAL
sequence position: 200

RelationshipXref10
type: RelationshipXref
id: 2022392
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2022392

SequenceSite3
type: SequenceSite
position status: EQUAL
sequence position: 19

RelationshipXref11
type: RelationshipXref
id: 211759
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211759

UnificationXref68
type: UnificationXref
id: REACT_151184
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151184.1

UnificationXref69
type: UnificationXref
id: CHEBI:28442
db: ChEBI

UnificationXref78
type: UnificationXref
id: 70106
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106

UnificationXref77
type: UnificationXref
id: CHEBI:15378
db: ChEBI

UnificationXref76
type: UnificationXref
id: REACT_5115
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5115.1

UnificationXref75
type: UnificationXref
id: 73473
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73473

UnificationXref74
type: UnificationXref
id: CHEBI:16908
db: ChEBI

UnificationXref73
type: UnificationXref
id: REACT_151444
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151444.1

UnificationXref72
type: UnificationXref
id: 2161597
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161597

UnificationXref71
type: UnificationXref
id: REACT_152334
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152334.1

UnificationXref70
type: UnificationXref
id: 2142799
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142799