UniProt:P65880
type: ProteinReference
xref: UnificationXref1948
organism: BioSource1

http://identifiers.org/pubmed/7923357
type: PublicationXref
id: 7923357
author: Mahtani, MM
author: Weaver, A
author: Clines, G
author: Trivedi, B
author: Daly, M
author: de la Chapelle, A
author: Kusumi, K
author: Reeve-Daly, MP
author: Hamilton, BA
author: Hästbacka, J
db: Pubmed
title: The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping
source: Cell 78:1073-87
year: 1994

http://identifiers.org/pubmed/10075700
type: PublicationXref
id: 10075700
author: Cooper, DM
author: Gu, C
db: Pubmed
title: Calmodulin-binding sites on adenylyl cyclase type VIII
source: J Biol Chem 274:8012-21
year: 1999

http://identifiers.org/pubmed/17970225
type: PublicationXref
id: 17970225
author: Muse WB, 3rd
author: Carroll, KS
author: Bhave, DP
db: Pubmed
title: Drug targets in mycobacterial sulfur metabolism
source: Infect Disord Drug Targets 7:140-58
year: 2007

6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol [ChEBI:64181]
type: SmallMoleculeReference
name: 6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol
xref: UnificationXref1727

2-methoxy-6-decaprenyl-1,4-benzoquinol [ChEBI:64180]
type: SmallMoleculeReference
name: 2-methoxy-6-decaprenyl-1,4-benzoquinol
xref: UnificationXref1721

http://identifiers.org/pubmed/18216330
type: PublicationXref
id: 18216330
author: Peters, SB
author: Daley, WP
author: Larsen, M
db: Pubmed
title: Extracellular matrix dynamics in development and regenerative medicine
source: J Cell Sci 121:255-64
year: 2008

http://identifiers.org/pubmed/11158296
type: PublicationXref
id: 11158296
author: Pelzer, W
author: Kmita, H
author: Diekert, K
author: Bedekovics, T
author: Lill, R
author: Prohl, C
author: Kispal, G
db: Pubmed
title: The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix
source: Mol Cell Biol 21:1089-97
year: 2001

UniProt:P65829
type: ProteinReference
xref: UnificationXref1847
organism: BioSource1

carbovir triphosphate
type: SmallMoleculeReference
name: carbovir triphosphate [ChEBI:64174]
xref: UnificationXref3421

carbovir diphosphate [ChEBI:64172]
type: SmallMoleculeReference
name: carbovir diphosphate
xref: UnificationXref3418

http://identifiers.org/pubmed/17697045
type: PublicationXref
id: 17697045
author: Mikoshiba, K
db: Pubmed
title: IP3 receptor/Ca2+ channel: from discovery to new signaling concepts
source: J Neurochem 102:1426-46
year: 2007

http://identifiers.org/pubmed/22101841
type: PublicationXref
id: 22101841
author: Puri, RV
author: Tyagi, AK
author: Khera, A
author: Reddy, PV
db: Pubmed
title: Iron storage proteins are essential for the survival and pathogenesis of Mycobacterium tuberculosis in THP-1 macrophages and the guinea pig model of infection
source: J Bacteriol 194:567-75
year: 2012

Cytochrome P450 - arranged by substrate type
type: Pathway
data source: Provenance1
pathway component: REACT 114508.8
pathway component: REACT 80420.9
pathway component: REACT 132547.5
evidence: Evidence450
xref: UnificationXref3194
xref: UnificationXref3193
pathway order: PathwayStep447
pathway order: PathwayStep443
pathway order: PathwayStep442
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/7356336
type: PublicationXref
id: 7356336
author: Logue, EA
author: Fall, RR
author: Hector, ML
author: Cochran, BC
db: Pubmed
title: Subcellular localization of 3-methylcrotonyl-coenzyme A carboxylase in bovine kidney
source: Arch Biochem Biophys 199:28-36
year: 1980

17-Demethoxy-17-allylamino geldanamycin
type: SmallMoleculeReference
name: 17AAG
name: tanespimycin [ChEBI:64153]
name: 17-N-allylamino-17-demethoxygeldanamycin
name: 17-allylaminogeldanamycin
name: 17-(Allylamino)geldanamycin
name: 17-(Allylamino)-17-demethoxygeldanamycin
name: 17-AAG
name: 17-demethoxy-17-(2-propenylamino)geldanamycin
name: tanespimycin
xref: UnificationXref3488

http://identifiers.org/pubmed/1371749
type: PublicationXref
id: 1371749
author: Saxty, BA
author: Groot, PH
author: Kmetz, PJ
author: Near, JC
author: Hughes, SA
author: Franklin, M
author: Wells, TN
author: Gloger, IS
author: Elshourbagy, NA
db: Pubmed
title: Cloning and expression of a human ATP-citrate lyase cDNA
source: Eur J Biochem 204:491-9
year: 1992

Siroheme
type: SmallMoleculeReference
name: Siroheme [ChEBI:9166]
xref: UnificationXref5226

http://identifiers.org/pubmed/9771708
type: PublicationXref
id: 9771708
author: Ahmad, W
author: Swank, RT
author: Krakow, D
author: King, LM
author: Cohn, DH
author: Abbas, H
author: Ahmad, M
author: Rusiniak, ME
author: Superti-Furga, A
author: Cantor, RM
author: ul Haque, MF
author: Haque, S
db: Pubmed
title: Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse
source: Nat Genet 20:157-62
year: 1998

8,9-EpETrE [ChEBI:34490]
type: SmallMoleculeReference
name: 8,9-EpETrE
xref: UnificationXref1620

http://identifiers.org/pubmed/6105839
type: PublicationXref
id: 6105839
author: Jones, ME
db: Pubmed
title: Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis.
source: Annu Rev Biochem 49:253-79
year: 1980

http://identifiers.org/pubmed/16169847
type: PublicationXref
id: 16169847
author: Treadwell, L
author: Warrington, JA
author: Wolfe, CL
author: Norcum, MT
db: Pubmed
title: A three-dimensional working model of the multienzyme complex of aminoacyl-tRNA synthetases based on electron microscopic placements of tRNA and proteins
source: J Biol Chem 280:38870-8
year: 2005

http://identifiers.org/pubmed/19957260
type: PublicationXref
id: 19957260
author: Lambert, DM
author: Ferrer, JL
author: Bauvois, C
author: Wouters, J
author: Borel, F
author: Labar, G
db: Pubmed
title: Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling
source: Chembiochem 11:218-27
year: 2010

Neuronal System
type: Pathway
data source: Provenance1
pathway component: REACT 102443.9
evidence: Evidence551
xref: RelationshipXref530
xref: UnificationXref3690
xref: UnificationXref3691
pathway order: PathwayStep543
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/19693541
type: PublicationXref
id: 19693541
author: Gordon, MK
author: Hahn, RA
db: Pubmed
title: Collagens
source: Cell Tissue Res 339:247-57
year: 2010

2-Deoxy-D-ribose 1-phosphate
type: SmallMoleculeReference
name: 2-Deoxy-D-ribose 1-phosphate [ChEBI:28542]
xref: UnificationXref2004

http://identifiers.org/pubmed/17266529
type: PublicationXref
id: 17266529
author: Hyde, JE
db: Pubmed
title: Targeting purine and pyrimidine metabolism in human apicomplexan parasites
source: Curr Drug Targets 8:31-47
year: 2007

5,6-EpETrE [ChEBI:34450]
type: SmallMoleculeReference
name: 5,6-EpETrE
xref: UnificationXref1617

http://identifiers.org/pubmed/9889013
type: PublicationXref
id: 9889013
author: Galindo, A
author: Cederbaum, SD
author: Sweetman, L
author: Roe, DS
author: Mardach, R
db: Pubmed
title: Isolated isobutyryl-CoA dehydrogenase deficiency: an unrecognized defect in human valine metabolism.
source: Mol Genet Metab 65:264-71
year: 1999

Metabolism of carbohydrates
type: Pathway
data source: Provenance1
pathway component: REACT 134911.5
pathway component: REACT 88984.9
pathway component: REACT 155148.3
pathway component: REACT 99558.9
pathway component: Galactose catabolism
evidence: Evidence87
xref: UnificationXref504
xref: RelationshipXref72
xref: UnificationXref505
pathway order: PathwayStep64
pathway order: PathwayStep84
pathway order: PathwayStep68
pathway order: PathwayStep77
pathway order: PathwayStep74
display name: Carbohydrate metabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/23083115
type: PublicationXref
id: 23083115
author: Rothman, Edward D
author: Banaszak Holl, Mark M
author: Goldstein, Elizabeth L
author: Fang, Ming
author: Welch, Kathleen B
author: Turner, A Simon
author: Orr, Bradford G
author: Les, Clifford M
author: Fisher, Gary J
db: Pubmed
title: Type I Collagen D-Spacing in Fibril Bundles of Dermis, Tendon, and Bone: Bridging between Nano- and Micro-Level Tissue Hierarchy
source: ACS Nano
year: 2012

MPS I - Hurler syndrome
type: Pathway
data source: Provenance1
pathway component: REACT 134911.5
evidence: Evidence503
xref: UnificationXref3521
xref: UnificationXref3520
pathway order: PathwayStep84
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Transport and synthesis of PAPS
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction38
evidence: Evidence81
xref: UnificationXref474
xref: UnificationXref473
xref: RelationshipXref67
pathway order: PathwayStep78
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Synthesis of DNA
type: Pathway
data source: Provenance1
pathway component: REACT 85176.9
evidence: Evidence10
xref: UnificationXref37
xref: UnificationXref36
pathway order: PathwayStep9
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

3-Oxodecanoyl-CoA [ChEBI:28528]
type: SmallMoleculeReference
name: 3-Oxodecanoyl-CoA
xref: UnificationXref869

Phase 1 - Functionalization of compounds
type: Pathway
data source: Provenance1
pathway component: REACT 108053.9
pathway component: Cytochrome P450 - arranged by substrate type
pathway component: REACT 107215.9
evidence: Evidence459
xref: UnificationXref3243
xref: RelationshipXref484
xref: UnificationXref3244
pathway order: PathwayStep448
pathway order: PathwayStep456
pathway order: PathwayStep453
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

ChEBI:28533 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestanoyl-CoA
type: SmallMoleculeReference
name: 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestanoyl-CoA
xref: UnificationXref1345

http://identifiers.org/pubmed/16756494
type: PublicationXref
id: 16756494
author: Waterham, HR
author: Wanders, RJ
db: Pubmed
title: Biochemistry of mammalian peroxisomes revisited
source: Annu Rev Biochem 75:295-332
year: 2006

http://identifiers.org/pubmed/10479480
type: PublicationXref
id: 10479480
author: McGuinness, MC
author: Steinberg, SJ
author: Wang, SJ
author: Watkins, PA
db: Pubmed
title: Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein
source: Mol Genet Metab 68:32-42
year: 1999

http://identifiers.org/pubmed/20876572
type: PublicationXref
id: 20876572
author: Froese, D Sean
author: Ugochukwu, Emelie
author: Gileadi, Carina
author: Wu, Xuchu
author: Krysztofinska, Ewelina
author: Kochan, Grazyna
author: Yue, Wyatt W
author: Oppermann, U
author: Gravel, RA
author: Muniz, João R C
db: Pubmed
title: Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation
source: J. Biol. Chem. 285:38204-13
year: 2010

http://identifiers.org/pubmed/10448521
type: PublicationXref
id: 10448521
author: Seetharam, B
db: Pubmed
title: Receptor-mediated endocytosis of cobalamin (vitamin B12)
source: Annu. Rev. Nutr. 19:173-95
year: 1999

Metabolism of water-soluble vitamins and cofactors
type: Pathway
data source: Provenance1
pathway component: REACT 84027.9
pathway component: Biotin transport and metabolism
pathway component: Vitamin B5 (pantothenate) metabolism
pathway component: REACT 86332.9
pathway component: REACT 166969.1
pathway component: REACT 146491.5
pathway component: REACT 132489.5
evidence: Evidence370
xref: UnificationXref2618
xref: UnificationXref2619
xref: RelationshipXref371
pathway order: PathwayStep364
pathway order: PathwayStep347
pathway order: PathwayStep340
pathway order: PathwayStep345
pathway order: PathwayStep367
pathway order: PathwayStep353
pathway order: PathwayStep337
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/7564244
type: PublicationXref
id: 7564244
author: Mooyer, P
author: Wanders, RJ
db: Pubmed
title: D-2-hydroxyglutaric acidaemia: identification of a new enzyme, D-2-hydroxyglutarate dehydrogenase, localized in mitochondria
source: J Inherit Metab Dis 18:194-6
year: 1995

D-Fructose 2,6-bisphosphate [ChEBI:28602]
type: SmallMoleculeReference
name: D-Fructose 2,6-bisphosphate
xref: UnificationXref197

http://identifiers.org/pubmed/12482854
type: PublicationXref
id: 12482854
author: Horton, JD
author: Moon, YA
db: Pubmed
title: Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade
source: J Biol Chem 278:7335-43
year: 2003

Coproporphyrinogen I
type: SmallMoleculeReference
name: Coproporphyrinogen I [ChEBI:3879]
xref: UnificationXref3079

http://identifiers.org/pubmed/16539657
type: PublicationXref
id: 16539657
author: Kakiuchi, C
author: Hayashi, A
author: Ishiwata, M
author: Kato, T
db: Pubmed
title: XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells
source: J Neurochem 97:545-55
year: 2006

http://identifiers.org/pubmed/4016087
type: PublicationXref
id: 4016087
author: Roth, JA
author: Pearce, LB
db: Pubmed
title: Human brain monoamine oxidase type B: mechanism of deamination as probed by steady-state methods
source: Biochemistry 24:1821-6
year: 1985

Clearance of serotonin
type: Pathway
data source: Provenance1
name: Serotonin clearance from the synaptic cleft
pathway component: REACT 103922.9
evidence: Evidence543
xref: UnificationXref3670
xref: UnificationXref3671
pathway order: PathwayStep535
display name: Clearance of seratonin
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/19300440
type: PublicationXref
id: 19300440
author: Kim, YG
author: Park, BJ
author: Lee, S
author: Kwon, OS
author: Kim, KJ
author: Lee, SJ
author: Park, SY
db: Pubmed
title: Redox-switch modulation of human SSADH by dynamic catalytic loop
source: EMBO J 28:959-68
year: 2009

http://identifiers.org/pubmed/8257433
type: PublicationXref
id: 8257433
author: Hopkinson, DA
author: Edwards, YH
author: Whitehouse, DB
author: Ives, JH
author: Hollyoake, M
author: Putt, W
db: Pubmed
title: Phosphoglucomutase 1: a gene with two promoters and a duplicated first exon
source: Biochem J 296:417-22
year: 1993

http://identifiers.org/pubmed/10832746
type: PublicationXref
id: 10832746
author: Jakobs, C
author: Kiss, D
author: Linck, L
author: Gibson, KM
author: Pohowalla, P
author: Hogema, B
author: Rinaldo, P
author: Sweetman, L
author: Burlingame, TG
author: Roe, DS
author: Sacks, M
author: Millington, D
author: Vockley, J
author: Schutgens, RB
author: Steiner, RD
db: Pubmed
title: 2-Methylbutyryl-coenzyme A dehydrogenase deficiency: a new inborn error of L-isoleucine metabolism.
source: Pediatr Res 47:830-3
year: 2000

http://identifiers.org/pubmed/8186247
type: PublicationXref
id: 8186247
author: Ofman, R
author: Wanders, RJ
db: Pubmed
title: Purification of peroxisomal acyl-CoA: dihydroxyacetonephosphate acyltransferase from human placenta
source: Biochim Biophys Acta 1206:27-34
year: 1994

http://identifiers.org/pubmed/7317031
type: PublicationXref
id: 7317031
author: Orford, C R
author: Scott, J E
db: Pubmed
title: Dermatan sulphate-rich proteoglycan associates with rat tail-tendon collagen at the d band in the gap region
source: Biochem. J. 197:213-6
year: 1981

http://identifiers.org/pubmed/8619816
type: PublicationXref
id: 8619816
author: Kondo, M
author: Itakura, M
author: Takahashi, Y
author: Moritani, M
author: Yoshimoto, K
author: Yamaoka, T
author: Fujimura, H
author: Ii, S
author: Iwahana, H
db: Pubmed
title: Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis
source: Biochem Biophys Res Commun 219:249-255
year: 1996

http://identifiers.org/pubmed/16491085
type: PublicationXref
id: 16491085
author: Willemsen, MA
author: Jakobs, C
author: Weschke, B
author: Mills, PB
author: Omran, H
author: Plecko, B
author: Tacke, U
author: Clayton, PT
author: Baxter, P
author: Uhlenberg, B
author: Baumgartner, M
author: Struys, E
db: Pubmed
title: Mutations in antiquitin in individuals with pyridoxine-dependent seizures
source: Nat Med 12:307-9
year: 2006

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction141
evidence: Evidence247
xref: UnificationXref1654
xref: UnificationXref1653
xref: RelationshipXref219
pathway order: PathwayStep244
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/12519779
type: PublicationXref
id: 12519779
author: Ciufo, LF
author: Morgan, A
author: Evans, GJ
author: Barclay, JW
author: Burgoyne, RD
author: Fisher, RJ
author: Craig, TJ
db: Pubmed
title: Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis
source: J Biol Chem 278:10538-45
year: 2003

Signaling by PDGF
type: Pathway
data source: Provenance1
pathway component: REACT 112345.8
evidence: Evidence707
xref: UnificationXref4952
xref: UnificationXref4951
pathway order: PathwayStep725
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/12369887
type: PublicationXref
id: 12369887
author: Danielson, PB
db: Pubmed
title: The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans
source: Curr Drug Metab 3:561-97
year: 2002

http://identifiers.org/pubmed/10692433
type: PublicationXref
id: 10692433
author: Kijima, S
author: Fujita, M
author: Arata, Y
author: Ohtani, K
author: Kato, JY
db: Pubmed
title: Cdk2-dependent and -independent pathways in E2F-mediated S phase induction
source: J Biol Chem 275:6337-45
year: 2000

http://identifiers.org/pubmed/3932573
type: PublicationXref
id: 3932573
author: Kuhl, W
author: Beutler, E
db: Pubmed
title: Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism
source: J Lab Clin Med 106:573-7
year: 1985

http://identifiers.org/pubmed/16436075
type: PublicationXref
id: 16436075
author: Yamazaki, M
author: Wada, M
author: Nakamori, S
author: Awano, N
author: Takagi, H
author: Haitani, Y
db: Pubmed
title: Functional analysis of L-serine O-acetyltransferase from Corynebacterium glutamicum
source: FEMS Microbiol Lett 255:156-63
year: 2006

http://identifiers.org/pubmed/1894595
type: PublicationXref
id: 1894595
author: Burbaum, JJ
author: Schimmel, P
db: Pubmed
title: Structural relationships and the classification of aminoacyl-tRNA synthetases
source: J Biol Chem 266:16965-8
year: 1991

http://identifiers.org/pubmed/17139329
type: PublicationXref
id: 17139329
author: Rosen, ED
author: MacDougald, OA
db: Pubmed
title: Adipocyte differentiation from the inside out
source: Nat Rev Mol Cell Biol 7:885-96
year: 2006

carbovir monophosphate [ChEBI:64116]
type: SmallMoleculeReference
name: carbovir monophosphate
xref: UnificationXref3413

transport vesicle membrane
type: CellularLocationVocabulary
xref: UnificationXref613

http://identifiers.org/pubmed/10692424
type: PublicationXref
id: 10692424
author: van den Bosch, H
author: Fraaije, MW
author: Hilkes, YH
author: de Vet, EC
db: Pubmed
title: Alkyl-dihydroxyacetonephosphate synthase. Presence and role of flavin adenine dinucleotide
source: J Biol Chem 275:6276-83
year: 2000

abacavir monophosphate [ChEBI:64112]
type: SmallMoleculeReference
name: abacavir monophosphate
xref: UnificationXref3407

http://identifiers.org/pubmed/21173190
type: PublicationXref
id: 21173190
author: Agarwal, AK
author: Prasad, SS
author: Garg, A
db: Pubmed
title: Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria
source: J Lipid Res 52:451-62
year: 2011

http://identifiers.org/pubmed/19737009
type: PublicationXref
id: 19737009
author: Monteiro, G
author: Manta, B
author: Alvarez, B
author: Radi, R
author: Netto, LE
author: Botti, H
author: Hugo, M
author: Trujillo, M
author: Turell, L
db: Pubmed
title: Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics
source: Biochemistry 48:9416-26
year: 2009

http://identifiers.org/pubmed/8167409
type: PublicationXref
id: 8167409
author: McMahon, Jill A
author: Smolich, Beverly D
author: McMahon, Andrew P
author: Papkoff, Jackie
db: Pubmed
title: Wnt family proteins are secreted and associated with the cell surface
source: Mol. Biol. Cell 4:1267-75
year: 1993

http://identifiers.org/pubmed/3143362
type: PublicationXref
id: 3143362
author: Sakuraba, H
author: Nagao, Y
author: Suzuki, Y
author: Tsuji, A
author: Oshima, A
db: Pubmed
title: Cloning, sequencing, and expression of cDNA for human beta-galactosidase
source: Biochem. Biophys. Res. Commun. 157:238-44
year: 1988

http://identifiers.org/pubmed/17638697
type: PublicationXref
id: 17638697
author: Av-Gay, Y
author: Johnson, T
author: Miller, CC
author: Rawat, M
db: Pubmed
title: Innate protection of Mycobacterium smegmatis against the antimicrobial activity of nitric oxide is provided by mycothiol
source: Antimicrob Agents Chemother 51:3364-6
year: 2007

http://identifiers.org/pubmed/8411712
type: PublicationXref
id: 8411712
author: Kamijo, K
author: Osumi, T
author: Hashimoto, T
db: Pubmed
title: PMP70, the 70-kDa peroxisomal membrane protein: a member of the ATP-binding cassette transporters
source: Nippon Rinsho 51:2343-52
year: 1993

http://identifiers.org/pubmed/17478680
type: PublicationXref
id: 17478680
author: McMahon, HT
author: Kozlov, MM
author: Martens, S
db: Pubmed
title: How synaptotagmin promotes membrane fusion
source: Science 316:1205-8
year: 2007

http://identifiers.org/pubmed/9630604
type: PublicationXref
id: 9630604
author: Li, X
author: Hiratsuka, M
author: Suzuki, Y
author: Sakamoto, O
author: Narisawa, K
author: Aoki, Y
db: Pubmed
title: Identification of holocarboxylase synthetase (HCS) proteins in human placenta
source: Biochim. Biophys. Acta 1385:165-71
year: 1998

http://identifiers.org/pubmed/11805834
type: PublicationXref
id: 11805834
author: Olson, EN
author: Ouchi, T
author: Yanagisawa, H
author: Starcher, BC
author: Yanagisawa, M
author: Davis, EC
author: Richardson, JA
db: Pubmed
title: Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo
source: Nature 415:168-71
year: 2002

http://identifiers.org/pubmed/11805835
type: PublicationXref
id: 11805835
author: Dalton, Nancy
author: Nakamura, Tomoyuki
author: Iwanaga, Yoshitaka
author: Lozano, Pilar Ruiz
author: Honjo, T
author: Ross Jr, John
author: Kobuke, Kazuhiro
author: Takada, Y
author: Tashiro, Kei
author: Cheng, Ching-Feng
author: Ikeda, Yasuhiro
author: Minamisawa, Susumu
author: Hinek, Aleksander
author: Chien, Kenneth R
db: Pubmed
title: Fibulin-5/DANCE is essential for elastogenesis in vivo
source: Nature 415:171-5
year: 2002

http://identifiers.org/pubmed/16884737
type: PublicationXref
id: 16884737
author: Terwilliger, TC
author: Park, MS
author: Holton, JM
author: Pédelacq, JD
author: Kim, SI
author: Hung, LW
author: Rho, BS
author: Vigil, D
db: Pubmed
title: Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis
source: J Mol Biol 361:850-63
year: 2006

http://identifiers.org/pubmed/8428977
type: PublicationXref
id: 8428977
author: Sergeant, A
author: van der Rest, M
author: Gruffat, H
author: Mazzorana, M
db: Pubmed
title: Mechanisms of collagen trimer formation. Construction and expression of a recombinant minigene in HeLa cells reveals a direct effect of prolyl hydroxylation on chain assembly of type XII collagen
source: J. Biol. Chem. 268:3029-32
year: 1993

http://identifiers.org/pubmed/1908722
type: PublicationXref
id: 1908722
author: Poncz, M
author: Manning, DR
author: Brass, LF
author: Gagnon, AW
author: Gewirtz, A
author: Catani, L
db: Pubmed
title: Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes
source: Blood 78:1247-53
year: 1991

Glutathione synthesis and recycling
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction262
pathway component: BiochemicalReaction290
pathway component: BiochemicalReaction289
evidence: Evidence473
xref: RelationshipXref497
xref: UnificationXref3375
xref: UnificationXref3374
pathway order: PathwayStep469
pathway order: PathwayStep421
pathway order: PathwayStep468
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/18240029
type: PublicationXref
id: 18240029
author: Luttrell, LM
db: Pubmed
title: Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors
source: Mol Biotechnol 39:239-64
year: 2008

http://identifiers.org/pubmed/18155917
type: PublicationXref
id: 18155917
author: Paus, R
author: Zmijewski, MA
author: Slominski, A
author: Tobin, DJ
author: Wortsman, J
db: Pubmed
title: Melatonin in the skin: synthesis, metabolism and functions
source: Trends Endocrinol Metab 19:17-24
year: 2008

http://identifiers.org/pubmed/1466761
type: PublicationXref
id: 1466761
author: Notbohm, H
author: Yang, C
author: Mosler, S
author: Bodo, M
author: Lehmann, H
author: Bätge, B
author: Müller, PK
db: Pubmed
title: Comparative study on the thermostability of collagen I of skin and bone: influence of posttranslational hydroxylation of prolyl and lysyl residues
source: J Protein Chem 11:635-43
year: 1992

http://identifiers.org/pubmed/6300847
type: PublicationXref
id: 6300847
author: Filpula, D
author: Johnson, GG
author: Esty, AC
author: Jolly, DJ
author: Okayama, H
author: Bohlen, P
author: Berg, P
author: Hunkapillar, T
author: Friedmann, T
author: Shively, JE
db: Pubmed
title: Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase
source: Proc Natl Acad Sci U S A 80:477-81
year: 1983

(2S)-pristanoyl-CoA [ChEBI:64039]
type: SmallMoleculeReference
name: (2S)-2,6,10,14-tetramethylpentadecanoyl-CoA
name: (2S)-pristanoyl-coenzyme A
name: (2S)-2,6,10,14-tetramethylpentadecanoyl-coenzyme A
name: (2S)-pristanoyl-CoA
xref: UnificationXref1132

http://identifiers.org/pubmed/12573255
type: PublicationXref
id: 12573255
author: Hegele, RA
author: Cao, H
author: Mok, A
db: Pubmed
title: Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase
source: Genomics 81:1-5
year: 2003

http://identifiers.org/pubmed/19344236
type: PublicationXref
id: 19344236
author: Shoulders, MD
author: Raines, RT
db: Pubmed
title: Collagen structure and stability
source: Annu Rev Biochem 78:929-58
year: 2009

ROS
type: SmallMoleculeReference
name: Reactive oxygen species
name: Reactive oxygen species [ChEBI:26523]
xref: UnificationXref4616

Sphingolipid metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 118525.7
pathway component: REACT 137715.5
evidence: Evidence254
xref: RelationshipXref227
xref: UnificationXref1696
xref: UnificationXref1695
pathway order: PathwayStep251
pathway order: PathwayStep249
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/6311078
type: PublicationXref
id: 6311078
author: Hammarström, Sven
db: Pubmed
title: Leukotrienes
source: Annu Rev Biochem 52:355-77
year: 1983

http://identifiers.org/pubmed/22527994
type: PublicationXref
id: 22527994
author: Monaga, Madelyn
author: Campos, Derbis
db: Pubmed
title: Mucopolysaccharidosis type I: current knowledge on its pathophysiological mechanisms
source: Metab Brain Dis 27:121-9
year: 2012

http://identifiers.org/pubmed/12126930
type: PublicationXref
id: 12126930
author: Jakobs, C
author: Patel, A
author: Geraghty, MT
author: Thomas, GH
author: Schor, DS
author: Salomons, GS
author: Goh, DL
db: Pubmed
title: Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).
source: Mol Genet Metab 76:172-80
year: 2002

http://identifiers.org/pubmed/21245903
type: PublicationXref
id: 21245903
author: Kufer, TA
author: Sansonetti, PJ
db: Pubmed
title: NLR functions beyond pathogen recognition
source: Nat Immunol 12:121-8
year: 2011

UniProt:P65902
type: ProteinReference
xref: UnificationXref1896
organism: BioSource1

Coenzyme A biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction201
evidence: Evidence338
xref: UnificationXref2397
xref: RelationshipXref332
xref: UnificationXref2398
pathway order: PathwayStep335
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:P65908
type: ProteinReference
xref: UnificationXref2106
organism: BioSource1

Biotin transport and metabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction208
evidence: Evidence349
xref: UnificationXref2468
xref: UnificationXref2467
xref: RelationshipXref344
pathway order: PathwayStep346
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/18288277
type: PublicationXref
id: 18288277
author: Kersten, S
db: Pubmed
title: Peroxisome proliferator activated receptors and lipoprotein metabolism
source: PPAR Res 2008:132960
year: 2008

THF-polyglutamate
type: SmallMoleculeReference
name: Tetrahydrofolyl-[Glu](n)
name: Tetrahydrofolyl-[Glu](n) [ChEBI:9484]
name: Tetrahydrofolyl-[Glu](n+1)
xref: UnificationXref2508

http://identifiers.org/pubmed/17132626
type: PublicationXref
id: 17132626
author: Forman, HJ
author: Persechini, PM
author: Ojcius, DM
author: Ventura, AL
author: Rinna, A
author: Cruz, CM
db: Pubmed
title: ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages
source: J Biol Chem 282:2871-9
year: 2007

(S)-3-Hydroxyoctanoyl-CoA
type: SmallMoleculeReference
name: (S)-Hydroxyoctanoyl-CoA [ChEBI:28632]
name: (S)-Hydroxyoctanoyl-CoA
xref: UnificationXref884

Transport of fatty acids
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction379
evidence: Evidence679
xref: RelationshipXref617
xref: UnificationXref4500
xref: UnificationXref4499
pathway order: PathwayStep664
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/8163052
type: PublicationXref
id: 8163052
author: Gomis, R
author: Malaisse, WJ
author: Sener, A
author: Fernandez-Alvarez, J
author: Conget, I
author: Rasschaert, J
db: Pubmed
title: Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients
source: Diabetologia 37:177-81
year: 1994

http://identifiers.org/pubmed/19261352
type: PublicationXref
id: 19261352
author: de Chastellier, C
db: Pubmed
title: The many niches and strategies used by pathogenic mycobacteria for survival within host macrophages
source: Immunobiology 214:526-42
year: 2009

http://identifiers.org/pubmed/2844531
type: PublicationXref
id: 2844531
author: Siebold, B
author: Kühn, K
author: Deutzmann, R
db: Pubmed
title: The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagen
source: Eur J Biochem 176:617-24
year: 1988

http://identifiers.org/pubmed/1867713
type: PublicationXref
id: 1867713
author: Prockop, DJ
author: Engel, J
db: Pubmed
title: The zipper-like folding of collagen triple helices and the effects of mutations that disrupt the zipper
source: Annu Rev Biophys Biophys Chem 20:137-52
year: 1991

Biosynthesis of A2E, implicated in retinal degradation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction297
evidence: Evidence516
xref: UnificationXref3558
xref: UnificationXref3557
pathway order: PathwayStep510
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/14990995
type: PublicationXref
id: 14990995
author: Yoshida, K
author: Inoue, I
db: Pubmed
title: Regulation of Geminin and Cdt1 expression by E2F transcription factors
source: Oncogene 23:3802-12
year: 2004

3-Methyl-2-oxopentanoate
type: SmallMoleculeReference
name: 2-Oxo-3-methylvalerate
name: 3-Methyl-2-oxopentanoate [ChEBI:28654]
xref: UnificationXref2675

http://identifiers.org/pubmed/6434529
type: PublicationXref
id: 6434529
author: Chuang, DT
author: Cox, RP
author: Markovitz, PJ
db: Pubmed
title: Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.
source: J Biol Chem 259:11643-6
year: 1984

Chenodeoxycholoyl-CoA [ChEBI:28701]
type: SmallMoleculeReference
name: Chenodeoxycholoyl-CoA
xref: UnificationXref1348

http://identifiers.org/pubmed/8946167
type: PublicationXref
id: 8946167
author: Blanch, L
author: Anson, D S
author: Hopwood, J J
author: Scott, H S
author: Guo, X H
author: Karageorgos, L E
author: Weber, B
db: Pubmed
title: Structure and sequence of the human sulphamidase gene
source: DNA Res. 3:269-71
year: 1996

trans-Hex-2-enoyl-CoA [ChEBI:28706]
type: SmallMoleculeReference
name: trans-Hex-2-enoyl-CoA
xref: UnificationXref899

http://identifiers.org/pubmed/15158675
type: PublicationXref
id: 15158675
author: Abraham, EC
author: Carroll, JD
author: Edavana, VK
author: Pastuszak, I
author: Thampi, P
author: Elbein, AD
db: Pubmed
title: Cloning and expression of the trehalose-phosphate phosphatase of Mycobacterium tuberculosis: comparison to the enzyme from Mycobacterium smegmatis
source: Arch Biochem Biophys 426:250-7
year: 2004

http://identifiers.org/pubmed/11826276
type: PublicationXref
id: 11826276
author: Bennett, MJ
author: Rinaldo, P
author: Matern, D
db: Pubmed
title: Fatty acid oxidation disorders.
source: Annu Rev Physiol 64:477-502
year: 2002

http://identifiers.org/pubmed/9490415
type: PublicationXref
id: 9490415
author: Phillips, JH
author: Lanier, LL
author: Leong, C
author: Wu, J
author: Corliss, BC
db: Pubmed
title: Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
source: Nature 391:703-7
year: 1998

ChEBI:28726 3-oxotetradecanoyl-CoA
type: SmallMoleculeReference
name: 3-oxotetradecanoyl-CoA
name: 3-Oxotetradecanoyl-CoA
xref: UnificationXref821

http://identifiers.org/pubmed/10843999
type: PublicationXref
id: 10843999
author: Hannah, VC
author: Luong, A
author: Goldstein, JL
db: Pubmed
title: Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins.
source: J Biol Chem 275:26458-66
year: 2000

UnificationXref5020
type: UnificationXref
id: P67017
db: UniProt

UnificationXref5021
type: UnificationXref
id: 879269
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879269

UnificationXref5022
type: UnificationXref
id: REACT_27929
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27929.1

UnificationXref5023
type: UnificationXref
id: 879241
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879241

UnificationXref5025
type: UnificationXref
id: 879319
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879319

UnificationXref5024
type: UnificationXref
id: REACT_27345
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27345.1

UnificationXref5027
type: UnificationXref
id: O53831
db: UniProt

UnificationXref5026
type: UnificationXref
id: REACT_27279
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27279.1

UnificationXref5029
type: UnificationXref
id: REACT_27640
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27640.1

UnificationXref5028
type: UnificationXref
id: 879286
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879286

http://identifiers.org/pubmed/11742412
type: PublicationXref
id: 11742412
author: Saltiel, AR
author: Kahn, CR
db: Pubmed
title: Insulin signalling and the regulation of glucose and lipid metabolism
source: Nature 414:799-806
year: 2001

UnificationXref5030
type: UnificationXref
id: 879248
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879248

UnificationXref5033
type: UnificationXref
id: 879253
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879253

UnificationXref5034
type: UnificationXref
id: REACT_27769
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27769.1

UnificationXref5031
type: UnificationXref
id: REACT_27291
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27291.1

UnificationXref5032
type: UnificationXref
id: O53430
db: UniProt

UnificationXref5038
type: UnificationXref
id: REACT_27208
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27208.1

UnificationXref5037
type: UnificationXref
id: 879327
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879327

http://identifiers.org/pubmed/18660845
type: PublicationXref
id: 18660845
author: Zhao, FQ
author: Keating, AF
db: Pubmed
title: Functional properties and genomics of glucose transporters
source: Curr Genomics 8:113-28
year: 2007

UnificationXref5036
type: UnificationXref
id: REACT_27869
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27869.1

UnificationXref5035
type: UnificationXref
id: 879260
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879260

UDP-D-galactopyranose
type: SmallMolecule
entity reference: UDP-D-galactose [ChEBI:18307]
data source: Provenance1
name: UDPgalactose
name: UDP-D-galactose
xref: UnificationXref113
xref: UnificationXref114
cellular location: GO:0005796
comment: Reactome DB_ID: 735682
display name: UDP-Gal

UnificationXref5039
type: UnificationXref
id: 879299
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879299

UDP--N-acetylgalactosamine
type: SmallMolecule
entity reference: CHEBI:16650
data source: Provenance1
xref: UnificationXref107
xref: UnificationXref108
cellular location: GO:0005796
comment: Reactome DB_ID: 735700
display name: UDP-GalNAc

UDP
type: SmallMolecule
entity reference: CHEBI:17659
data source: Provenance1
xref: UnificationXref99
xref: UnificationXref98
cellular location: GO:0005796
comment: Reactome DB_ID: 205687

UDP-N-acetylglucosamine
type: SmallMolecule
entity reference: UDP-N-acetyl-D-glucosamine
data source: Provenance1
name: UDP-N-acetyl-D-glucosamine
xref: UnificationXref96
xref: UnificationXref95
cellular location: GO:0005796
comment: Reactome DB_ID: 914003
display name: UDP-GlcNAc

D-Mannose 6-phosphate
type: SmallMolecule
entity reference: CHEBI:17369
data source: Provenance1
xref: UnificationXref77
xref: UnificationXref76
cellular location: GO:0005829
comment: Reactome DB_ID: 532562
display name: Man6P

D-glucosamine 6-phosphate
type: SmallMolecule
entity reference: CHEBI:15873
data source: Provenance1
xref: UnificationXref65
xref: UnificationXref66
cellular location: GO:0005829
comment: Reactome DB_ID: 449701
display name: GlcN6P

L-Glutaminic acid
type: SmallMolecule
entity reference: CHEBI:16015
data source: Provenance1
name: L-Glutamic acid
name: L-Glutamate
xref: UnificationXref63
xref: UnificationXref62
cellular location: GO:0005829
comment: Reactome DB_ID: 29404
display name: L-Glu

D-Fructose 6-phosphoric acid
type: SmallMolecule
entity reference: CHEBI:15946
data source: Provenance1
name: D-Fructose 6-phosphate
name: Neuberg ester
xref: UnificationXref59
xref: UnificationXref60
cellular location: GO:0005829
comment: Reactome DB_ID: 29512
display name: Fru(6)P

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine
data source: Provenance1
name: L-2-Aminoglutaramic acid
xref: UnificationXref56
xref: UnificationXref57
cellular location: GO:0005829
comment: Reactome DB_ID: 29472
display name: L-Gln

http://identifiers.org/pubmed/18644377
type: PublicationXref
id: 18644377
author: Stultz, CM
author: Nerenberg, PS
db: Pubmed
title: Differential unfolding of alpha1 and alpha2 chains in type I collagen and collagenolysis
source: J Mol Biol 382:246-56
year: 2008

UnificationXref5000
type: UnificationXref
id: REACT_27622
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27622.1

UnificationXref5001
type: UnificationXref
id: P64707
db: UniProt

UnificationXref5007
type: UnificationXref
id: 879332
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879332

UnificationXref5006
type: UnificationXref
id: CHEBI:52442
db: ChEBI

UnificationXref5009
type: UnificationXref
id: P95189
db: UniProt

UnificationXref5008
type: UnificationXref
id: REACT_27562
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27562.1

UnificationXref5003
type: UnificationXref
id: REACT_27575
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27575.1

UnificationXref5002
type: UnificationXref
id: 879291
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879291

UnificationXref5005
type: UnificationXref
id: REACT_27245
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27245.1

UnificationXref5004
type: UnificationXref
id: 879298
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879298

http://identifiers.org/pubmed/12082143
type: PublicationXref
id: 12082143
author: Sherratt, MJ
author: Shuttleworth, CA
author: Kielty, CM
db: Pubmed
title: Elastic fibres
source: J Cell Sci 115:2817-28
year: 2002

http://identifiers.org/pubmed/15274622
type: PublicationXref
id: 15274622
author: Kim, JJ
author: Wang, M
author: Fu, Z
author: Paschke, R
author: Frerman, FE
author: Rao, KS
db: Pubmed
title: Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions
source: Biochemistry 43:9674-84
year: 2004

UnificationXref5011
type: UnificationXref
id: REACT_27548
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27548.1

UnificationXref5012
type: UnificationXref
id: 879274
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879274

UnificationXref5010
type: UnificationXref
id: 879317
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879317

Glycogen breakdown (glycogenolysis)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction27
pathway component: BiochemicalReaction25
pathway component: BiochemicalReaction23
pathway component: BiochemicalReaction26
pathway component: BiochemicalReaction24
evidence: Evidence65
xref: RelationshipXref43
xref: UnificationXref357
xref: UnificationXref356
pathway order: PathwayStep59
pathway order: PathwayStep62
pathway order: PathwayStep60
pathway order: PathwayStep58
pathway order: PathwayStep61
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref5019
type: UnificationXref
id: REACT_27547
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27547.2

UnificationXref5018
type: UnificationXref
id: 879313
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879313

UnificationXref5017
type: UnificationXref
id: CHEBI:52285
db: ChEBI

UnificationXref5016
type: UnificationXref
id: REACT_27804
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27804.2

UnificationXref5015
type: UnificationXref
id: 879264
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879264

http://identifiers.org/pubmed/6434534
type: PublicationXref
id: 6434534
author: Gracy, RW
author: Yuan, PM
author: Lu, HS
db: Pubmed
title: Primary structure of human triosephosphate isomerase
source: J Biol Chem 259:11958-68
year: 1984

UnificationXref5014
type: UnificationXref
id: CHEBI:52283
db: ChEBI

UnificationXref5013
type: UnificationXref
id: REACT_27149
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27149.1

http://identifiers.org/pubmed/15274629
type: PublicationXref
id: 15274629
author: Takeuchi, N
author: Heck, A
author: Spencer, AC
author: Watanabe, K
author: Spremulli, LL
db: Pubmed
title: Characterization of the human mitochondrial methionyl-tRNA synthetase
source: Biochemistry 43:9743-54
year: 2004

http://identifiers.org/pubmed/7354069
type: PublicationXref
id: 7354069
author: Anderson, PM
author: Desnick, RJ
db: Pubmed
title: Purification and properties of uroporphyrinogen I synthase from human erythrocytes. Identification of stable enzyme-substrate intermediates.
source: J Biol Chem 255:1993-9
year: 1980

UnificationXref5068
type: UnificationXref
id: REACT_27332
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27332.1

UnificationXref5069
type: UnificationXref
id: 879237
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879237

UnificationXref5063
type: UnificationXref
id: CHEBI:59632
db: ChEBI

UnificationXref5062
type: UnificationXref
id: REACT_27143
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27143.1

UnificationXref5061
type: UnificationXref
id: 879273
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879273

UnificationXref5060
type: UnificationXref
id: REACT_27473
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27473.1

UnificationXref5067
type: UnificationXref
id: 879279
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879279

http://identifiers.org/pubmed/10229653
type: PublicationXref
id: 10229653
author: Wallace, JC
author: Jitrapakdee, S
db: Pubmed
title: Structure, function and regulation of pyruvate carboxylase
source: Biochem J 340:1-16
year: 1999

UnificationXref5066
type: UnificationXref
id: CHEBI:59634
db: ChEBI

UnificationXref5065
type: UnificationXref
id: REACT_27320
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27320.2

UnificationXref5064
type: UnificationXref
id: 879267
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879267

Mycothiol metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 27281.1
pathway component: REACT 27216.1
pathway component: REACT 27144.1
pathway component: BiochemicalReaction432
pathway component: BiochemicalReaction431
xref: UnificationXref5094
xref: RelationshipXref696
xref: UnificationXref5095
xref: http://identifiers.org/pubmed/18772286
xref: http://identifiers.org/pubmed/17286835
pathway order: PathwayStep758
pathway order: PathwayStep750
pathway order: PathwayStep752
pathway order: PathwayStep757
pathway order: PathwayStep759
comment: Authored: Stephan, R, 2010-06-07
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: Mycothiol (MSH), a conjugate of glucosamine, cysteine and inositol, is the Actinobacteria equivalent of glutathione. It serves as a pool for both the unstable cysteine and reduction equivalents. Mycothiol takes part in enzymatic reactions including detoxification of electrophilic compounds, inactivation of reactive oxygen and nitrogen species, reductions, and isomerizations. M. smegmatis mutants devoid of MSH are sensitive to oxidative and nitrosative stress, and antibiotics. In M. tuberculosis, however, mycothiol synthesis is essential, no null mutants are known. Results from MshD mutants, which have about 1 per cent of MSH, show the importance of mycothiol in environments where antimicrobial factors, including reactive oxygen and reactive nitrogen intermediates, are formed, such as within macrophages (Newton et al, 2008; Rawat and Av-Gay, 2007)
organism: BioSource1

acetic acid, ion(1-)
type: SmallMoleculeReference
name: ethanoate
name: acetate
name: ACETATE ION
name: Ethanoat
name: CH3-COO(-)
name: Azetat
name: MeCO2 anion
name: acetate [ChEBI:30089]
xref: UnificationXref1522

UnificationXref5079
type: UnificationXref
id: REACT_27190
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27190.1

http://identifiers.org/pubmed/7354072
type: PublicationXref
id: 7354072
author: Bodlaender, P
author: Shemin, D
author: Bevan, DR
db: Pubmed
title: Mechanism of porphobilinogen synthase. Requirement of Zn2+ for enzyme activity.
source: J Biol Chem 255:2030-5
year: 1980

http://identifiers.org/pubmed/3082888
type: PublicationXref
id: 3082888
author: Glanville, RW
author: Bentz, H
author: Keene, DR
author: Morris, NP
author: Burgeson, RE
db: Pubmed
title: The tissue form of type VII collagen is an antiparallel dimer
source: J Biol Chem 261:5638-44
year: 1986

UnificationXref5072
type: UnificationXref
id: REACT_27304
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27304.1

UnificationXref5071
type: UnificationXref
id: 879311
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879311

UnificationXref5074
type: UnificationXref
id: REACT_27709
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27709.2

UnificationXref5073
type: UnificationXref
id: 879250
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879250

UnificationXref5076
type: UnificationXref
id: 879271
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879271

UnificationXref5075
type: UnificationXref
id: CHEBI:15735
db: ChEBI

UnificationXref5078
type: UnificationXref
id: 879245
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879245

UnificationXref5077
type: UnificationXref
id: REACT_27628
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27628.2

http://identifiers.org/pubmed/16183910
type: PublicationXref
id: 16183910
author: Wettschureck, N
author: Offermanns, S
db: Pubmed
title: Mammalian G proteins and their cell type specific functions
source: Physiol Rev 85:1159-204
year: 2005

UnificationXref5070
type: UnificationXref
id: REACT_27450
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27450.1

UnificationXref5048
type: UnificationXref
id: CHEBI:44348
db: ChEBI

UnificationXref5049
type: UnificationXref
id: 879288
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879288

http://identifiers.org/pubmed/10681399
type: PublicationXref
id: 10681399
author: Harris, RC
author: Capdevila, JH
author: Falck, JR
db: Pubmed
title: Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase
source: J Lipid Res 41:163-81
year: 2000

UnificationXref5046
type: UnificationXref
id: 879294
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879294

http://identifiers.org/pubmed/17850181
type: PublicationXref
id: 17850181
author: Mayr, G
author: Kerscher, T
author: Esparza-Gordillo, J
author: Gruber, C
author: Marenholz, I
author: Worm, M
author: Schulz, H
author: Rohde, K
author: Lee, YA
author: Söderhäll, C
author: Rüschendorf, F
author: Albrecht, M
author: Hubner, N
author: Wahn, U
db: Pubmed
title: Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis
source: PLoS Biol 5:e242
year: 2007

UnificationXref5047
type: UnificationXref
id: REACT_27752
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27752.2

UnificationXref5045
type: UnificationXref
id: CHEBI:27632
db: ChEBI

UnificationXref5044
type: UnificationXref
id: REACT_27144
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27144.1

UnificationXref5043
type: UnificationXref
id: 879325
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879325

UnificationXref5042
type: UnificationXref
id: REACT_27249
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27249.1

UnificationXref5041
type: UnificationXref
id: 879281
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879281

UnificationXref5040
type: UnificationXref
id: REACT_27216
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27216.1

UnificationXref5057
type: UnificationXref
id: 879244
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879244

UnificationXref5058
type: UnificationXref
id: REACT_27525
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27525.2

UnificationXref5059
type: UnificationXref
id: 879246
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879246

UnificationXref5054
type: UnificationXref
id: 879283
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879283

UnificationXref5053
type: UnificationXref
id: CHEBI:59629
db: ChEBI

UnificationXref5056
type: UnificationXref
id: CHEBI:59630
db: ChEBI

UnificationXref5055
type: UnificationXref
id: REACT_27604
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27604.1

http://identifiers.org/pubmed/15576367
type: PublicationXref
id: 15576367
author: Keating, L
author: Wooff, EE
author: Parish, T
author: Wheeler, PR
author: Coldham, NG
author: Hewinson, RG
author: Gordon, SV
db: Pubmed
title: Functional demonstration of reverse transsulfuration in the Mycobacterium tuberculosis complex reveals that methionine is the preferred sulfur source for pathogenic Mycobacteria
source: J Biol Chem 280:8069-78
year: 2005

UnificationXref5050
type: UnificationXref
id: REACT_27385
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27385.2

UnificationXref5052
type: UnificationXref
id: REACT_27656
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27656.1

UnificationXref5051
type: UnificationXref
id: 879233
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879233

http://identifiers.org/pubmed/22001560
type: PublicationXref
id: 22001560
author: Boudko, SP
author: Bächinger, HP
author: Engel, J
db: Pubmed
title: The crucial role of trimerization domains in collagen folding
source: Int J Biochem Cell Biol
year: 2011

UnificationXref5080
type: UnificationXref
id: 879293
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879293

UnificationXref5081
type: UnificationXref
id: REACT_27193
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27193.1

http://identifiers.org/pubmed/12473104
type: PublicationXref
id: 12473104
author: Carroll, JD
author: Pan, YT
author: Elbein, AD
db: Pubmed
title: Trehalose-phosphate synthase of Mycobacterium tuberculosis. Cloning, expression and properties of the recombinant enzyme
source: Eur J Biochem 269:6091-100
year: 2002

UnificationXref5088
type: UnificationXref
id: REACT_27231
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27231.1

UnificationXref5089
type: UnificationXref
id: O07927
db: UniProt

UnificationXref5086
type: UnificationXref
id: REACT_27785
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27785.2

UnificationXref5087
type: UnificationXref
id: 879266
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879266

UnificationXref5084
type: UnificationXref
id: CHEBI:10545
db: ChEBI

UnificationXref5085
type: UnificationXref
id: 879326
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879326

UnificationXref5082
type: UnificationXref
id: 879235
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879235

UnificationXref5083
type: UnificationXref
id: REACT_27281
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27281.1

D-threo-Isocitric acid
type: SmallMoleculeReference
name: (1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylate [ChEBI:151]
name: Isocitric acid
name: (1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylate
xref: UnificationXref1216

UnificationXref5090
type: UnificationXref
id: 879285
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879285

UnificationXref5091
type: UnificationXref
id: REACT_27374
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27374.1

UnificationXref5092
type: UnificationXref
id: 879322
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879322

Synthesis of IP2, IP, and Ins in the cytosol
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction43
pathway component: BiochemicalReaction42
pathway component: BiochemicalReaction41
evidence: Evidence91
xref: RelationshipXref79
xref: UnificationXref533
xref: UnificationXref532
pathway order: PathwayStep87
pathway order: PathwayStep88
pathway order: PathwayStep86
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref5097
type: UnificationXref
id: 868701
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=868701

UnificationXref5098
type: UnificationXref
id: REACT_27652
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27652.1

UnificationXref5099
type: UnificationXref
id: O06353
db: UniProt

UnificationXref5093
type: UnificationXref
id: REACT_27243
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27243.1

UnificationXref5094
type: UnificationXref
id: 870331
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=870331

UnificationXref5095
type: UnificationXref
id: REACT_27191
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27191.1

UnificationXref5096
type: UnificationXref
id: CHEBI:18283
db: ChEBI

UnificationXref2867
type: UnificationXref
id: 4233677
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233677

UnificationXref2868
type: UnificationXref
id: REACT_92799
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92799.9

UnificationXref2865
type: UnificationXref
id: 4233674
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233674

UnificationXref2866
type: UnificationXref
id: 4233675
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233675

RelationshipXref219
type: RelationshipXref
id: GO:0019373
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref217
type: RelationshipXref
id: GO:0004301
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2869
type: UnificationXref
id: 4236066
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236066

RelationshipXref218
type: RelationshipXref
id: 4235812
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235812

RelationshipXref215
type: RelationshipXref
id: 4234849
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234849

RelationshipXref216
type: RelationshipXref
id: GO:0006691
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2860
type: UnificationXref
id: REACT_102882
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102882.9

RelationshipXref213
type: RelationshipXref
id: GO:0019371
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref214
type: RelationshipXref
id: GO:0042626
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref211
type: RelationshipXref
id: GO:0008116
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2863
type: UnificationXref
id: REACT_2911
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2911.2

RelationshipXref212
type: RelationshipXref
id: 4234174
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234174

UnificationXref2864
type: UnificationXref
id: P0A4Z0
db: UniProt

UnificationXref2861
type: UnificationXref
id: CHEBI:16467
db: ChEBI

RelationshipXref210
type: RelationshipXref
id: GO:0033559
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2862
type: UnificationXref
id: 29468
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29468

Activation of Chaperone Genes by ATF6-alpha
type: Pathway
data source: Provenance1
pathway component: TemplateReaction2
evidence: Evidence31
xref: UnificationXref126
xref: UnificationXref127
pathway order: PathwayStep29
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2854
type: UnificationXref
id: 34575
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=34575

UnificationXref2855
type: UnificationXref
id: REACT_5577
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5577.1

UnificationXref2856
type: UnificationXref
id: P63642
db: UniProt

UnificationXref2857
type: UnificationXref
id: 4233680
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233680

http://identifiers.org/pubmed/18772396
type: PublicationXref
id: 18772396
author: Zhang, X
author: Shinjo, SM
author: Rasheed, BA
author: Lin, JC
author: Carter, H
author: Jones, S
author: Keir, S
author: Parmigiani, G
author: Yan, H
author: McLendon, R
author: Olivi, A
author: Nikolsky, Y
author: Diaz Jr, LA
author: Tekleab, H
author: Vogelstein, B
author: Kinzler, KW
author: Velculescu, VE
author: Papadopoulos, N
author: Mankoo, P
author: Marie, SK
author: Parsons, DW
author: Busam, DA
author: Riggins, GJ
author: Bigner, DD
author: Karchin, R
author: Hartigan, J
author: Angenendt, P
author: Leary, RJ
author: Smith, DR
author: Strausberg, RL
author: Gallia, GL
author: Siu, IM
author: Nikolskaya, T
db: Pubmed
title: An integrated genomic analysis of human glioblastoma multiforme
source: Science 321:1807-12
year: 2008

RelationshipXref228
type: RelationshipXref
id: GO:0097269
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2858
type: UnificationXref
id: 4233681
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233681

RelationshipXref229
type: RelationshipXref
id: 4235833
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235833

UnificationXref2859
type: UnificationXref
id: 4233683
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233683

RelationshipXref224
type: RelationshipXref
id: GO:0017040
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref225
type: RelationshipXref
id: 4235557
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235557

RelationshipXref226
type: RelationshipXref
id: GO:0006687
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref227
type: RelationshipXref
id: GO:0006665
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref220
type: RelationshipXref
id: GO:0019369
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2850
type: UnificationXref
id: REACT_30784
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30784.10

RelationshipXref221
type: RelationshipXref
id: GO:0008117
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2851
type: UnificationXref
id: 29968
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29968

RelationshipXref222
type: RelationshipXref
id: 4235115
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235115

UnificationXref2852
type: UnificationXref
id: REACT_3861
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3861.3

RelationshipXref223
type: RelationshipXref
id: GO:0030148
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2853
type: UnificationXref
id: CHEBI:15682
db: ChEBI

http://identifiers.org/pubmed/15845384
type: PublicationXref
id: 15845384
author: Ohira, RH
author: Dipple, KM
author: McCabe, ER
author: Zhang, YH
db: Pubmed
title: Human and murine glycerol kinase: influence of exon 18 alternative splicing on function
source: Biochem Biophys Res Commun 331:239-46
year: 2005

Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction49
evidence: Evidence103
xref: UnificationXref639
xref: RelationshipXref92
xref: UnificationXref638
pathway order: PathwayStep100
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref230
type: RelationshipXref
id: GO:0043430
db: GENE ONTOLOGY
relationship type: MI:0355

G alpha (s) signalling events
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction418
evidence: Evidence711
xref: UnificationXref4959
xref: UnificationXref4960
pathway order: PathwayStep729
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref239
type: RelationshipXref
id: 4235149
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235149

Propionyl-CoA catabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction86
pathway component: BiochemicalReaction85
evidence: Evidence154
xref: RelationshipXref130
xref: UnificationXref1005
xref: UnificationXref1004
pathway order: PathwayStep151
pathway order: PathwayStep150
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2889
type: UnificationXref
id: 4235425
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235425

UnificationXref2887
type: UnificationXref
id: O06401
db: UniProt

http://identifiers.org/pubmed/18388293
type: PublicationXref
id: 18388293
author: Kumar, R
author: An, S
author: Benkovic, SJ
author: Sheets, ED
db: Pubmed
title: Reversible compartmentalization of de novo purine biosynthetic complexes in living cells
source: Science 320:103-6
year: 2008

UnificationXref2888
type: UnificationXref
id: 4235424
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235424

RelationshipXref233
type: RelationshipXref
id: GO:0031325
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2885
type: UnificationXref
id: 1237165
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1237165

RelationshipXref234
type: RelationshipXref
id: GO:0006112
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2886
type: UnificationXref
id: REACT_76320
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_76320.1

RelationshipXref231
type: RelationshipXref
id: 4235819
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235819

UnificationXref2883
type: UnificationXref
id: REACT_14918
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14918.2

RelationshipXref232
type: RelationshipXref
id: GO:0006744
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2884
type: UnificationXref
id: CHEBI:58533
db: ChEBI

RelationshipXref237
type: RelationshipXref
id: GO:0050999
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2881
type: UnificationXref
id: CHEBI:17509
db: ChEBI

RelationshipXref238
type: RelationshipXref
id: GO:0046209
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2882
type: UnificationXref
id: 353106
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=353106

RelationshipXref235
type: RelationshipXref
id: GO:0003934
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref236
type: RelationshipXref
id: 4235506
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235506

UnificationXref2880
type: UnificationXref
id: REACT_159699
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159699.3

RelationshipXref241
type: RelationshipXref
id: 4235145
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235145

RelationshipXref240
type: RelationshipXref
id: GO:0008746
db: GENE ONTOLOGY
relationship type: MI:0355

Fibroblast Growth Factor Receptor (FGFR) signaling
type: Pathway
data source: Provenance1
pathway component: Downstream signaling of activated FGFR
evidence: Evidence501
xref: RelationshipXref510
xref: UnificationXref3516
xref: UnificationXref3517
pathway order: PathwayStep495
display name: Signaling by FGFR
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/16839620
type: PublicationXref
id: 16839620
author: Kushner, JP
author: Phillips, JD
author: Ajioka, RS
db: Pubmed
title: Biosynthesis of heme in mammals
source: Biochim Biophys Acta 1763:723-36
year: 2006

UnificationXref2876
type: UnificationXref
id: REACT_4362
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4362.2

UnificationXref2877
type: UnificationXref
id: 4233839
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233839

UnificationXref2878
type: UnificationXref
id: REACT_156734
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156734.3

UnificationXref2879
type: UnificationXref
id: 4236083
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236083

http://identifiers.org/pubmed/15901732
type: PublicationXref
id: 15901732
author: Krämer, R
author: Strelkov, S
author: Meniche, X
author: Wolf, A
author: Morbach, S
author: Schomburg, D
author: Daffé, M
author: Tropis, M
author: Chami, M
author: Gebhardt, H
db: Pubmed
title: The crucial role of trehalose and structurally related oligosaccharides in the biosynthesis and transfer of mycolic acids in Corynebacterineae
source: J Biol Chem 280:26573-85
year: 2005

RelationshipXref242
type: RelationshipXref
id: GO:0004333
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2872
type: UnificationXref
id: 31503
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31503

RelationshipXref243
type: RelationshipXref
id: 4233795
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233795

UnificationXref2873
type: UnificationXref
id: REACT_5613
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5613.1

RelationshipXref244
type: RelationshipXref
id: GO:0006099
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2874
type: UnificationXref
id: CHEBI:18020
db: ChEBI

RelationshipXref245
type: RelationshipXref
id: GO:0051990
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2875
type: UnificationXref
id: 31311
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31311

RelationshipXref246
type: RelationshipXref
id: 4235244
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235244

http://identifiers.org/pubmed/11481433
type: PublicationXref
id: 11481433
author: St John, G
author: Tempst, P
author: Ruan, J
author: Erdjument-Bromage, H
author: Brot, N
author: Weissbach, H
author: Nathan, C
db: Pubmed
title: Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates
source: Proc Natl Acad Sci U S A 98:9901-6
year: 2001

RelationshipXref247
type: RelationshipXref
id: GO:0006103
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref248
type: RelationshipXref
id: GO:0044237
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2870
type: UnificationXref
id: REACT_82995
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82995.9

RelationshipXref249
type: RelationshipXref
id: GO:0009055
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2871
type: UnificationXref
id: CHEBI:15786
db: ChEBI

Stoichiometry10
type: Stoichiometry
physical entity: Protein25
stoichiometric coefficient: 1.0

Stoichiometry19
type: Stoichiometry
physical entity: Mn(III)
stoichiometric coefficient: 1.0

Stoichiometry14
type: Stoichiometry
physical entity: Mg++
stoichiometric coefficient: 1.0

Stoichiometry13
type: Stoichiometry
physical entity: Protein27
stoichiometric coefficient: 1.0

Stoichiometry12
type: Stoichiometry
physical entity: Protein26
stoichiometric coefficient: 2.0

Stoichiometry11
type: Stoichiometry
physical entity: Protein24
stoichiometric coefficient: 3.0

Stoichiometry18
type: Stoichiometry
physical entity: Coenzyme R
stoichiometric coefficient: 4.0

Stoichiometry17
type: Stoichiometry
physical entity: Protein29
stoichiometric coefficient: 4.0

Stoichiometry16
type: Stoichiometry
physical entity: Mg++
stoichiometric coefficient: 1.0

Stoichiometry15
type: Stoichiometry
physical entity: Protein28
stoichiometric coefficient: 2.0

Stoichiometry20
type: Stoichiometry
physical entity: Protein30
stoichiometric coefficient: 2.0

Stoichiometry21
type: Stoichiometry
physical entity: Mg++
stoichiometric coefficient: 1.0

UnificationXref2891
type: UnificationXref
id: REACT_141400
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141400.5

UnificationXref2890
type: UnificationXref
id: 4235427
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235427

UnificationXref2893
type: UnificationXref
id: REACT_128074
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128074.5

UnificationXref2892
type: UnificationXref
id: 4236320
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236320

UnificationXref2895
type: UnificationXref
id: REACT_80079
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80079.9

UnificationXref2894
type: UnificationXref
id: 4236321
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236321

UnificationXref2897
type: UnificationXref
id: 209793
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=209793

inferred from electronic annotation
type: EvidenceCodeVocabulary
xref: UnificationXref13

UnificationXref2896
type: UnificationXref
id: CHEBI:17697
db: ChEBI

Stoichiometry23
type: Stoichiometry
physical entity: Mg++
stoichiometric coefficient: 1.0

UnificationXref2899
type: UnificationXref
id: 71285
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71285

Stoichiometry22
type: Stoichiometry
physical entity: Protein33
stoichiometric coefficient: 1.0

UnificationXref2898
type: UnificationXref
id: REACT_16027
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16027.3

Stoichiometry25
type: Stoichiometry
physical entity: 5'-Adenylic acid
stoichiometric coefficient: 2.0

Stoichiometry24
type: Stoichiometry
physical entity: Protein34
stoichiometric coefficient: 1.0

Stoichiometry27
type: Stoichiometry
physical entity: 5'-Adenylic acid
stoichiometric coefficient: 2.0

Stoichiometry26
type: Stoichiometry
physical entity: Protein35
stoichiometric coefficient: 2.0

Stoichiometry29
type: Stoichiometry
physical entity: 5'-Adenylic acid
stoichiometric coefficient: 2.0

Stoichiometry28
type: Stoichiometry
physical entity: Protein35
stoichiometric coefficient: 2.0

Stoichiometry31
type: Stoichiometry
physical entity: Protein36
stoichiometric coefficient: 2.0

'Ac-CoA [mitochondrial matrix]' positively regulates 'Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate'
type: Control
data source: Provenance1
xref: UnificationXref270
controlled: BiochemicalReaction14
control type: ACTIVATION
controller: Acetyl coenzyme A

'ATP [cytosol]' negatively regulates 'PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex'
type: Control
data source: Provenance1
xref: UnificationXref351
controlled: BiochemicalReaction25
control type: INHIBITION
controller: Adenosine 5'-triphosphate

Stoichiometry32
type: Stoichiometry
physical entity: 5'-Adenylic acid
stoichiometric coefficient: 2.0

'D-Fructose 2,6-bisphosphate [cytosol]' positively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Provenance1
xref: UnificationXref196
controlled: BiochemicalReaction10
control type: ACTIVATION
controller: D-Fructose 2,6-bisphosphate

Stoichiometry30
type: Stoichiometry
physical entity: 5'-Adenylic acid
stoichiometric coefficient: 2.0

'ADP [cytosol]' positively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Provenance1
xref: UnificationXref200
controlled: BiochemicalReaction10
control type: ACTIVATION
controller: Adenosine 5'-diphosphate

'ATP [cytosol]' negatively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Provenance1
xref: UnificationXref191
controlled: BiochemicalReaction10
control type: INHIBITION
controller: Adenosine 5'-triphosphate

'AMP [cytosol]' positively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Provenance1
xref: UnificationXref192
controlled: BiochemicalReaction10
control type: ACTIVATION
controller: 5'-Adenylic acid

Cell redox homeostasis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction406
pathway component: BiochemicalReaction404
pathway component: BiochemicalReaction408
pathway component: BiochemicalReaction407
pathway component: BiochemicalReaction409
pathway component: BiochemicalReaction405
pathway component: BiochemicalReaction403
xref: RelationshipXref668
xref: http://identifiers.org/pubmed/21270886
xref: UnificationXref4867
xref: UnificationXref4868
xref: http://identifiers.org/pubmed/17012768
pathway order: PathwayStep711
pathway order: PathwayStep705
pathway order: PathwayStep708
pathway order: PathwayStep709
pathway order: PathwayStep707
pathway order: PathwayStep710
pathway order: PathwayStep706
comment: The most important response of Mtb to oxidative stress is provided by catalase and peroxiredoxins, both of which get their reducing equivalents through a network of disulfide proteins and, finally, from NAD(P)H. Multiple redundancies make choosing a good drug target difficult (Koul et al. 2011). Optimum efficacy can only be expected from inhibitors of the most upstream components of the redox cascades, i.e. the NAD(P)H-dependent reductases TrxB and Lpd (Jaeger & Flohe 2006).
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Authored: Stephan, R, 2011-01-10
organism: BioSource1

'CIT [cytosol]' negatively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Provenance1
xref: UnificationXref187
controlled: BiochemicalReaction10
control type: INHIBITION
controller: Citrate

'G6P [cytosol]' negatively regulates 'PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex'
type: Control
data source: Provenance1
xref: UnificationXref352
controlled: BiochemicalReaction25
control type: INHIBITION
controller: alpha-D-Glucose 6-phosphate

'BH4 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
type: Control
data source: Provenance1
xref: UnificationXref1760
controlled: BiochemicalReaction147
control type: INHIBITION
controller: SmallMolecule306

Stoichiometry39
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 4.0

trans,cis-Lauro-2,6-dienoyl-CoA
type: SmallMoleculeReference
name: trans,cis-Lauro-2,6-dienoyl-CoA [ChEBI:28387]
xref: UnificationXref944

Stoichiometry38
type: Stoichiometry
physical entity: Protein40
stoichiometric coefficient: 2.0

Stoichiometry37
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 2.0

Stoichiometry36
type: Stoichiometry
physical entity: Protein39
stoichiometric coefficient: 2.0

Stoichiometry35
type: Stoichiometry
physical entity: DPN
stoichiometric coefficient: 2.0

Stoichiometry34
type: Stoichiometry
physical entity: 5'-Adenylic acid
stoichiometric coefficient: 2.0

Stoichiometry33
type: Stoichiometry
physical entity: Protein36
stoichiometric coefficient: 2.0

Stoichiometry40
type: Stoichiometry
physical entity: Protein40
stoichiometric coefficient: 4.0

Stoichiometry41
type: Stoichiometry
physical entity: Protein44
stoichiometric coefficient: 2.0

Stoichiometry42
type: Stoichiometry
physical entity: Protein45
stoichiometric coefficient: 2.0

Stoichiometry43
type: Stoichiometry
physical entity: Protein46
stoichiometric coefficient: 2.0

PKA activation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction295
evidence: Evidence489
xref: UnificationXref3472
xref: UnificationXref3473
xref: RelationshipXref507
pathway order: PathwayStep483
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref201
type: RelationshipXref
id: GO:0008374
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref200
type: RelationshipXref
id: GO:0006656
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref203
type: RelationshipXref
id: GO:0035965
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref202
type: RelationshipXref
id: 4235534
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235534

RelationshipXref205
type: RelationshipXref
id: GO:0006644
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref204
type: RelationshipXref
id: GO:0046474
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref207
type: RelationshipXref
id: 4235768
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235768

Stoichiometry49
type: Stoichiometry
physical entity: sulfate
stoichiometric coefficient: 2.0

RelationshipXref206
type: RelationshipXref
id: GO:0005324
db: GENE ONTOLOGY
relationship type: MI:0355

Stoichiometry48
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

RelationshipXref209
type: RelationshipXref
id: GO:0043651
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref208
type: RelationshipXref
id: GO:0036109
db: GENE ONTOLOGY
relationship type: MI:0359

Stoichiometry45
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 2.0

Stoichiometry44
type: Stoichiometry
physical entity: H+
stoichiometric coefficient: 2.0

Stoichiometry47
type: Stoichiometry
physical entity: sulfate
stoichiometric coefficient: 2.0

Stoichiometry46
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Stoichiometry55
type: Stoichiometry
physical entity: Complex33
stoichiometric coefficient: 2.0

Stoichiometry56
type: Stoichiometry
physical entity: Protein53
stoichiometric coefficient: 1.0

Stoichiometry57
type: Stoichiometry
physical entity: bile salts and acids
stoichiometric coefficient: 2.0

Stoichiometry58
type: Stoichiometry
physical entity: Complex35
stoichiometric coefficient: 2.0

Stoichiometry59
type: Stoichiometry
physical entity: Protein56
stoichiometric coefficient: 1.0

Stoichiometry50
type: Stoichiometry
physical entity: Mg++
stoichiometric coefficient: 1.0

Stoichiometry52
type: Stoichiometry
physical entity: Complex31
stoichiometric coefficient: 2.0

Stoichiometry51
type: Stoichiometry
physical entity: Protein51
stoichiometric coefficient: 1.0

Stoichiometry54
type: Stoichiometry
physical entity: Protein52
stoichiometric coefficient: 1.0

Stoichiometry53
type: Stoichiometry
physical entity: Mg++
stoichiometric coefficient: 1.0

Stoichiometry68
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 14.0

Stoichiometry69
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 6.0

Stoichiometry66
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 14.0

Stoichiometry67
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 14.0

http://identifiers.org/pubmed/6307276
type: PublicationXref
id: 6307276
author: Odermatt, E
author: Furthmayr, H
author: Wiedemann, H
author: Timpl, R
author: Engel, J
db: Pubmed
title: Electron-microscopical approach to a structural model of intima collagen
source: Biochem J 211:303-11
year: 1983

http://identifiers.org/pubmed/12033919
type: PublicationXref
id: 12033919
author: Sareen, D
author: Steffek, M
author: Newton, GL
author: Fahey, RC
db: Pubmed
title: ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases
source: Biochemistry 41:6885-90
year: 2002

http://identifiers.org/pubmed/19416660
type: PublicationXref
id: 19416660
author: Ren, M
author: Xu, Y
author: Malhotra, A
author: Schlame, M
db: Pubmed
title: Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species
source: Biochim Biophys Acta 1791:314-20
year: 2009

Stoichiometry61
type: Stoichiometry
physical entity: Protein58
stoichiometric coefficient: 2.0

Stoichiometry60
type: Stoichiometry
physical entity: Protein57
stoichiometric coefficient: 1.0

Stoichiometry65
type: Stoichiometry
physical entity: Malonyl coenzyme A
stoichiometric coefficient: 7.0

Stoichiometry64
type: Stoichiometry
physical entity: Protein61
stoichiometric coefficient: 2.0

Stoichiometry63
type: Stoichiometry
physical entity: Protein61
stoichiometric coefficient: 2.0

Stoichiometry62
type: Stoichiometry
physical entity: Protein60
stoichiometric coefficient: 4.0

Stoichiometry77
type: Stoichiometry
physical entity: Protein96
stoichiometric coefficient: 4.0

Stoichiometry78
type: Stoichiometry
physical entity: Protein97
stoichiometric coefficient: 4.0

Stoichiometry79
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 3.0

Amino acid transport across the plasma membrane
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction299
pathway component: BiochemicalReaction301
pathway component: BiochemicalReaction300
pathway component: BiochemicalReaction302
evidence: Evidence526
xref: RelationshipXref518
xref: UnificationXref3610
xref: UnificationXref3609
pathway order: PathwayStep519
pathway order: PathwayStep516
pathway order: PathwayStep518
pathway order: PathwayStep517
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Androgen biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction129
evidence: Evidence222
xref: UnificationXref1488
xref: RelationshipXref191
xref: UnificationXref1487
pathway order: PathwayStep219
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/15381398
type: PublicationXref
id: 15381398
author: Jaffe, EK
db: Pubmed
title: The porphobilinogen synthase catalyzed reaction mechanism
source: Bioorg Chem 32:316-25
year: 2004

Stoichiometry74
type: Stoichiometry
physical entity: Protein93
stoichiometric coefficient: 2.0

Stoichiometry73
type: Stoichiometry
physical entity: Protein92
stoichiometric coefficient: 2.0

Stoichiometry76
type: Stoichiometry
physical entity: Protein95
stoichiometric coefficient: 6.0

Stoichiometry75
type: Stoichiometry
physical entity: Protein94
stoichiometric coefficient: 4.0

Stoichiometry70
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 7.0

Stoichiometry72
type: Stoichiometry
physical entity: Protein18
stoichiometric coefficient: 4.0

Stoichiometry71
type: Stoichiometry
physical entity: SmallMolecule99
stoichiometric coefficient: 8.0

Stoichiometry88
type: Stoichiometry
physical entity: Protein99
stoichiometric coefficient: 4.0

Stoichiometry89
type: Stoichiometry
physical entity: Note: the coordinates are copied over from Homo sapiens.
stoichiometric coefficient: 2.0

http://identifiers.org/pubmed/14578398
type: PublicationXref
id: 14578398
author: Yue, BY
author: Ueda, J
db: Pubmed
title: Distribution of myocilin and extracellular matrix components in the corneoscleral meshwork of human eyes
source: Invest Ophthalmol Vis Sci 44:4772-9
year: 2003

Stoichiometry87
type: Stoichiometry
physical entity: Protein98
stoichiometric coefficient: 2.0

Stoichiometry86
type: Stoichiometry
physical entity: FADH2
stoichiometric coefficient: 3.0

Stoichiometry85
type: Stoichiometry
physical entity: Acetyl coenzyme A
stoichiometric coefficient: 3.0

Stoichiometry84
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 3.0

Stoichiometry83
type: Stoichiometry
physical entity: H+
stoichiometric coefficient: 3.0

Stoichiometry82
type: Stoichiometry
physical entity: DPN
stoichiometric coefficient: 3.0

Stoichiometry81
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 3.0

Stoichiometry80
type: Stoichiometry
physical entity: Flavin adenine dinucleotide
stoichiometric coefficient: 3.0

(S)-Hydroxydecanoyl-CoA
type: SmallMoleculeReference
name: (S)-3-Hydroxydecanoyl-CoA
name: (S)-Hydroxydecanoyl-CoA [ChEBI:28325]
xref: UnificationXref864

Stoichiometry99
type: Stoichiometry
physical entity: Homologues of OXCT1
stoichiometric coefficient: 2.0

Stoichiometry91
type: Stoichiometry
physical entity: Complex49
stoichiometric coefficient: 1.0

Stoichiometry92
type: Stoichiometry
physical entity: Note: the coordinates are copied over from Homo sapiens.
stoichiometric coefficient: 2.0

Stoichiometry93
type: Stoichiometry
physical entity: Complex50
stoichiometric coefficient: 1.0

Stoichiometry94
type: Stoichiometry
physical entity: Complex50
stoichiometric coefficient: 1.0

Stoichiometry95
type: Stoichiometry
physical entity: Note: the coordinates are copied over from Homo sapiens.
stoichiometric coefficient: 2.0

Stoichiometry96
type: Stoichiometry
physical entity: Complex52
stoichiometric coefficient: 1.0

Stoichiometry97
type: Stoichiometry
physical entity: Acetyl coenzyme A
stoichiometric coefficient: 2.0

Stoichiometry98
type: Stoichiometry
physical entity: Note: the coordinates are copied over from Homo sapiens.
stoichiometric coefficient: 4.0

http://identifiers.org/pubmed/7923172
type: PublicationXref
id: 7923172
author: Momparler, RL
author: Laliberte, J
db: Pubmed
title: Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA
source: Cancer Res 54:5401-7
year: 1994

Stoichiometry90
type: Stoichiometry
physical entity: adenosylcobalamin
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/20435355
type: PublicationXref
id: 20435355
author: Palczewski, Krzysztof
db: Pubmed
title: Retinoids for treatment of retinal diseases
source: Trends Pharmacol. Sci. 31:284-95
year: 2010

Activation of NMDA receptor upon glutamate binding and postsynaptic events
type: Pathway
data source: Provenance1
pathway component: REACT 130032.5
evidence: Evidence548
xref: UnificationXref3684
xref: UnificationXref3685
pathway order: PathwayStep540
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Branched-chain amino acid catabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction240
pathway component: BiochemicalReaction239
pathway component: BiochemicalReaction231
pathway component: BiochemicalReaction237
pathway component: BiochemicalReaction236
pathway component: BiochemicalReaction234
pathway component: BiochemicalReaction241
pathway component: BiochemicalReaction238
pathway component: BiochemicalReaction243
pathway component: BiochemicalReaction242
pathway component: BiochemicalReaction235
pathway component: BiochemicalReaction232
pathway component: BiochemicalReaction233
evidence: Evidence393
xref: UnificationXref2783
xref: UnificationXref2782
xref: RelationshipXref400
pathway order: PathwayStep385
pathway order: PathwayStep383
pathway order: PathwayStep388
pathway order: PathwayStep387
pathway order: PathwayStep382
pathway order: PathwayStep384
pathway order: PathwayStep390
pathway order: PathwayStep386
pathway order: PathwayStep379
pathway order: PathwayStep380
pathway order: PathwayStep389
pathway order: PathwayStep381
pathway order: PathwayStep378
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/20807551
type: PublicationXref
id: 20807551
author: Noël, Jacques
author: Diochot, Sylvie
author: Baron, Anne
author: Deval, Emmanuel
author: Gasull, Xavier
author: Salinas, Miguel
author: Lingueglia, Eric
db: Pubmed
title: Acid-sensing ion channels (ASICs): pharmacology and implication in pain
source: Pharmacol. Ther. 128:549-58
year: 2010

http://identifiers.org/pubmed/19261456
type: PublicationXref
id: 19261456
author: Procko, E
author: Gaudet, R
db: Pubmed
title: Antigen processing and presentation: TAPping into ABC transporters
source: Curr Opin Immunol 21:84-91
year: 2009

http://identifiers.org/pubmed/14091597
type: PublicationXref
id: 14091597
author: Lamy, M
author: MARIE, J
author: MAROTEAUX, P
author: Leveque, B
db: Pubmed
title: [A NEW DYSOSTOSIS WITH URINARY ELIMINATION OF CHONDROITIN SULFATE B]
source: Presse Med 71:1849-52
year: 1963

UnificationXref179
type: UnificationXref
id: 4233615
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233615

UnificationXref180
type: UnificationXref
id: 4233616
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233616

UnificationXref181
type: UnificationXref
id: 4233617
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233617

UnificationXref186
type: UnificationXref
id: REACT_109655
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_109655.9

UnificationXref187
type: UnificationXref
id: 4233627
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233627

UnificationXref188
type: UnificationXref
id: CHEBI:30769
db: ChEBI

UnificationXref189
type: UnificationXref
id: 76190
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76190

UnificationXref182
type: UnificationXref
id: 4233618
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233618

UnificationXref183
type: UnificationXref
id: 4233619
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233619

UnificationXref184
type: UnificationXref
id: 4233620
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233620

UnificationXref185
type: UnificationXref
id: 4233622
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233622

UnificationXref191
type: UnificationXref
id: 4233626
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233626

UnificationXref192
type: UnificationXref
id: 4233623
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233623

UnificationXref190
type: UnificationXref
id: REACT_2769
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2769.2

UnificationXref199
type: UnificationXref
id: REACT_2510
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2510.1

UnificationXref197
type: UnificationXref
id: CHEBI:28602
db: ChEBI

UnificationXref198
type: UnificationXref
id: 30533
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30533

UnificationXref195
type: UnificationXref
id: REACT_2677
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2677.2

UnificationXref196
type: UnificationXref
id: 4233625
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233625

http://identifiers.org/pubmed/4358634
type: PublicationXref
id: 4358634
author: Roth, DG
author: Deuel, TF
author: Shelton, E
db: Pubmed
title: Purification and properties of phosphoribosyl pyrophosphate synthetase from rat liver
source: J Biol Chem 249:291-296
year: 1974

http://identifiers.org/pubmed/18215067
type: PublicationXref
id: 18215067
author: Holmes, RP
author: Murray, MS
author: Lowther, WT
db: Pubmed
title: Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design
source: Biochemistry 47:2439-49
year: 2008

UnificationXref193
type: UnificationXref
id: CHEBI:16027
db: ChEBI

UnificationXref194
type: UnificationXref
id: 76577
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76577

http://identifiers.org/pubmed/21479626
type: PublicationXref
id: 21479626
author: Sass, JO
db: Pubmed
title: Inborn errors of ketogenesis and ketone body utilization
source: J Inherit Metab Dis
year: 2011

UnificationXref158
type: UnificationXref
id: REACT_140554
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140554.5

UnificationXref157
type: UnificationXref
id: 4236293
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236293

UnificationXref159
type: UnificationXref
id: CHEBI:17665
db: ChEBI

Glycolysis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction12
pathway component: BiochemicalReaction11
pathway component: BiochemicalReaction13
pathway component: BiochemicalReaction9
pathway component: BiochemicalReaction10
evidence: Evidence48
xref: UnificationXref240
xref: RelationshipXref31
xref: UnificationXref241
pathway order: PathwayStep43
pathway order: PathwayStep45
pathway order: PathwayStep44
pathway order: PathwayStep42
pathway order: PathwayStep41
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref160
type: UnificationXref
id: 30537
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30537

UnificationXref161
type: UnificationXref
id: REACT_3817
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3817.2

UnificationXref162
type: UnificationXref
id: P64192
db: UniProt

UnificationXref163
type: UnificationXref
id: 4233630
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233630

UnificationXref164
type: UnificationXref
id: 4233631
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233631

UnificationXref165
type: UnificationXref
id: 4233633
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233633

UnificationXref166
type: UnificationXref
id: REACT_78538
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78538.9

UnificationXref167
type: UnificationXref
id: CHEBI:15422
db: ChEBI

UnificationXref169
type: UnificationXref
id: REACT_2812
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2812.1

UnificationXref168
type: UnificationXref
id: 113592
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592

http://identifiers.org/pubmed/16865347
type: PublicationXref
id: 16865347
author: Gundelfinger, ED
author: Schoch, S
db: Pubmed
title: Molecular organization of the presynaptic active zone
source: Cell Tissue Res 326:379-91
year: 2006

http://identifiers.org/pubmed/16816140
type: PublicationXref
id: 16816140
author: Westlake, C
author: Cole, SP
author: Deeley, RG
db: Pubmed
title: Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
source: Physiol Rev 86:849-99
year: 2006

UnificationXref170
type: UnificationXref
id: CHEBI:16761
db: ChEBI

http://identifiers.org/pubmed/13679574
type: PublicationXref
id: 13679574
author: Bouvier, M
author: Rousseau, G
author: Angers, S
author: Charest, PG
author: Kohout, T
author: Azzi, M
author: Piñeyro, G
db: Pubmed
title: Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
source: Proc Natl Acad Sci U S A 100:11406-11
year: 2003

UnificationXref173
type: UnificationXref
id: CHEBI:16905
db: ChEBI

UnificationXref174
type: UnificationXref
id: 30014
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30014

UnificationXref171
type: UnificationXref
id: 29370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370

UnificationXref172
type: UnificationXref
id: REACT_2741
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2741.1

UnificationXref177
type: UnificationXref
id: 4233613
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233613

UnificationXref178
type: UnificationXref
id: 4233614
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233614

UnificationXref175
type: UnificationXref
id: REACT_3740
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3740.1

UnificationXref176
type: UnificationXref
id: P65690
db: UniProt

UnificationXref139
type: UnificationXref
id: 4235610
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235610

UnificationXref135
type: UnificationXref
id: 4235605
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235605

UnificationXref136
type: UnificationXref
id: P63966
db: UniProt

UnificationXref137
type: UnificationXref
id: 4235608
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235608

UnificationXref138
type: UnificationXref
id: 4235609
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235609

UnificationXref143
type: UnificationXref
id: 4236340
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236340

UnificationXref142
type: UnificationXref
id: REACT_160044
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160044.3

UnificationXref145
type: UnificationXref
id: 4236341
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236341

UnificationXref144
type: UnificationXref
id: REACT_140190
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140190.5

http://identifiers.org/pubmed/14559994
type: PublicationXref
id: 14559994
author: Iwakoshi, NN
author: Lee, AH
author: Glimcher, LH
db: Pubmed
title: XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
source: Mol Cell Biol 23:7448-59
year: 2003

UnificationXref141
type: UnificationXref
id: 4235611
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235611

UnificationXref140
type: UnificationXref
id: REACT_130552
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130552.5

http://identifiers.org/pubmed/13538944
type: PublicationXref
id: 13538944
author: Tsuboi, KK
author: Hudson, PB
author: Estrada, J
db: Pubmed
title: Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties.
source: J Biol Chem 231:19-29
year: 1958

http://identifiers.org/pubmed/18096503
type: PublicationXref
id: 18096503
author: Blankman, JL
author: Cravatt, BF
author: Simon, GM
db: Pubmed
title: A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
source: Chem Biol 14:1347-56
year: 2007

UnificationXref148
type: UnificationXref
id: 4233686
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233686

UnificationXref149
type: UnificationXref
id: 4235612
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235612

UnificationXref146
type: UnificationXref
id: REACT_135689
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135689.5

UnificationXref147
type: UnificationXref
id: P64247
db: UniProt

UnificationXref156
type: UnificationXref
id: REACT_138769
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138769.5

UnificationXref155
type: UnificationXref
id: 4236342
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236342

UnificationXref154
type: UnificationXref
id: REACT_140924
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140924.5

UnificationXref153
type: UnificationXref
id: 4236344
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236344

UnificationXref152
type: UnificationXref
id: REACT_147418
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147418.5

UnificationXref151
type: UnificationXref
id: 4236343
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236343

UnificationXref150
type: UnificationXref
id: REACT_140577
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140577.5

http://identifiers.org/pubmed/3091600
type: PublicationXref
id: 3091600
author: Schettino, MI
author: Gragnaniello, V
author: Cartenì-Farina, M
author: Della Ragione, F
author: Zappia, V
db: Pubmed
title: Purification and characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase from human placenta
source: J Biol Chem 261:12324-9
year: 1986

UnificationXref113
type: UnificationXref
id: 735682
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=735682

UnificationXref114
type: UnificationXref
id: REACT_23172
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23172.2

UnificationXref115
type: UnificationXref
id: 4235273
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235273

UnificationXref116
type: UnificationXref
id: 4235274
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235274

UnificationXref117
type: UnificationXref
id: REACT_126005
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126005.5

UnificationXref118
type: UnificationXref
id: 4236311
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236311

UnificationXref119
type: UnificationXref
id: REACT_143888
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143888.5

Elastic fibre formation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction332
evidence: Evidence592
xref: UnificationXref4100
xref: UnificationXref4099
pathway order: PathwayStep579
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref121
type: UnificationXref
id: REACT_131781
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131781.5

UnificationXref120
type: UnificationXref
id: 4236292
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236292

UnificationXref123
type: UnificationXref
id: 4235613
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235613

UnificationXref122
type: UnificationXref
id: P64411
db: UniProt

UnificationXref126
type: UnificationXref
id: 4236345
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236345

UnificationXref127
type: UnificationXref
id: REACT_130778
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130778.5

UnificationXref124
type: UnificationXref
id: 4235614
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235614

UnificationXref125
type: UnificationXref
id: REACT_135442
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135442.5

UnificationXref128
type: UnificationXref
id: 4236346
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236346

UnificationXref129
type: UnificationXref
id: REACT_127376
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127376.5

UnificationXref130
type: UnificationXref
id: P63429
db: UniProt

http://identifiers.org/pubmed/18243674
type: PublicationXref
id: 18243674
author: Purcell, AW
author: Elliott, T
db: Pubmed
title: Molecular machinations of the MHC-I peptide loading complex
source: Curr Opin Immunol 20:75-81
year: 2008

UnificationXref134
type: UnificationXref
id: P0A548
db: UniProt

UnificationXref133
type: UnificationXref
id: REACT_134586
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134586.5

UnificationXref132
type: UnificationXref
id: 4235602
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235602

UnificationXref131
type: UnificationXref
id: 4234204
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234204

ChEBI:26125 phytosterols
type: SmallMoleculeReference
name: phytosterols
xref: UnificationXref596

RelationshipXref189
type: RelationshipXref
id: GO:0050327
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref100
type: UnificationXref
id: 4235270
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235270

UnificationXref101
type: UnificationXref
id: 4235271
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235271

RelationshipXref187
type: RelationshipXref
id: GO:0015721
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref188
type: RelationshipXref
id: GO:0008206
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref182
type: RelationshipXref
id: 4234622
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234622

RelationshipXref181
type: RelationshipXref
id: GO:0015432
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref180
type: RelationshipXref
id: 4234631
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234631

RelationshipXref186
type: RelationshipXref
id: 4234564
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234564

http://identifiers.org/pubmed/12005437
type: PublicationXref
id: 12005437
author: Stoker, NG
author: Murray-Rust, J
author: McDonald, NQ
author: McAlister, MS
author: Movahedzadeh, F
author: Norman, RA
db: Pubmed
title: Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis
source: Structure 10:393-402
year: 2002

RelationshipXref185
type: RelationshipXref
id: 4234586
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234586

RelationshipXref184
type: RelationshipXref
id: GO:0008396
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref183
type: RelationshipXref
id: GO:0006699
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2902
type: UnificationXref
id: 209934
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=209934

UnificationXref2903
type: UnificationXref
id: REACT_16026
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16026.2

UnificationXref2904
type: UnificationXref
id: O53764
db: UniProt

http://identifiers.org/pubmed/16314626
type: PublicationXref
id: 16314626
author: Forastiere, AA
author: Goldwasser, MA
author: Eastern Cooperative Oncology, Group
author: Burtness, B
author: Mattar, B
author: Flood, W
db: Pubmed
title: Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study
source: J Clin Oncol 23:8646-54
year: 2005

UnificationXref2905
type: UnificationXref
id: 4234795
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234795

UnificationXref2900
type: UnificationXref
id: REACT_5336
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5336.2

UniProt:P95276
type: ProteinReference
xref: UnificationXref1647
organism: BioSource1

UnificationXref2901
type: UnificationXref
id: CHEBI:16796
db: ChEBI

RelationshipXref176
type: RelationshipXref
id: GO:0004467
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref177
type: RelationshipXref
id: 4234638
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234638

UnificationXref110
type: UnificationXref
id: 4235286
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235286

RelationshipXref178
type: RelationshipXref
id: 4234465
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234465

UnificationXref111
type: UnificationXref
id: REACT_134404
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134404.5

RelationshipXref179
type: RelationshipXref
id: GO:0016289
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref112
type: UnificationXref
id: CHEBI:18307
db: ChEBI

Citric acid cycle (TCA cycle)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction150
pathway component: BiochemicalReaction149
pathway component: BiochemicalReaction148
pathway component: BiochemicalReaction151
evidence: Evidence272
xref: UnificationXref1803
xref: UnificationXref1804
xref: RelationshipXref244
pathway order: PathwayStep267
pathway order: PathwayStep268
pathway order: PathwayStep266
pathway order: PathwayStep269
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref107
type: UnificationXref
id: 735700
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=735700

UnificationXref106
type: UnificationXref
id: CHEBI:16650
db: ChEBI

RelationshipXref171
type: RelationshipXref
id: GO:0006695
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref109
type: UnificationXref
id: 4235285
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235285

RelationshipXref170
type: RelationshipXref
id: 4234658
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234658

UnificationXref108
type: UnificationXref
id: REACT_23253
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23253.1

RelationshipXref173
type: RelationshipXref
id: 4234568
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234568

UnificationXref103
type: UnificationXref
id: 4235276
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235276

RelationshipXref172
type: RelationshipXref
id: GO:0008123
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref102
type: UnificationXref
id: REACT_132873
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132873.5

RelationshipXref175
type: RelationshipXref
id: 4234583
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234583

UnificationXref105
type: UnificationXref
id: REACT_126646
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126646.5

RelationshipXref174
type: RelationshipXref
id: GO:0033778
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref104
type: UnificationXref
id: 4235277
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235277

UnificationXref2911
type: UnificationXref
id: REACT_29991
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29991.10

UnificationXref2912
type: UnificationXref
id: 113535
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113535

UnificationXref2910
type: UnificationXref
id: 4236218
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236218

UnificationXref2915
type: UnificationXref
id: REACT_10649
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10649.2

UnificationXref2916
type: UnificationXref
id: 113575
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113575

UnificationXref2913
type: UnificationXref
id: REACT_5022
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5022.2

UnificationXref2914
type: UnificationXref
id: 193446
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193446

xenobiotic compounds
type: SmallMoleculeReference
name: xenobiotic [ChEBI:35703]
name: xenobiotic
xref: UnificationXref4366

UnificationXref2909
type: UnificationXref
id: REACT_77232
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77232.9

UnificationXref2908
type: UnificationXref
id: 4236217
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236217

UnificationXref2907
type: UnificationXref
id: REACT_100679
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100679.9

UnificationXref2906
type: UnificationXref
id: 4234797
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234797

Vitamin B5 (pantothenate) metabolism
type: Pathway
data source: Provenance1
pathway component: Coenzyme A biosynthesis
evidence: Evidence339
xref: UnificationXref2400
xref: UnificationXref2399
xref: RelationshipXref333
pathway order: PathwayStep336
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2920
type: UnificationXref
id: CHEBI:16891
db: ChEBI

UnificationXref2921
type: UnificationXref
id: 389678
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389678

UnificationXref2922
type: UnificationXref
id: REACT_17634
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17634.1

UnificationXref2923
type: UnificationXref
id: O07727
db: UniProt

UnificationXref2924
type: UnificationXref
id: 4235003
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235003

UnificationXref2925
type: UnificationXref
id: 4235004
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235004

UnificationXref2926
type: UnificationXref
id: 4235005
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235005

EGFR interacts with phospholipase C-gamma
type: Pathway
data source: Provenance1
pathway component: REACT 114367.8
evidence: Evidence494
xref: RelationshipXref508
xref: UnificationXref3482
xref: UnificationXref3483
pathway order: PathwayStep488
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2927
type: UnificationXref
id: 4235007
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235007

http://identifiers.org/pubmed/14725767
type: PublicationXref
id: 14725767
author: Bate, M
author: Luke, RW
author: McAlister, MS
author: Ernill, RJ
author: Norman, RA
author: Paterson, DS
author: Barry, ST
author: Colls, JG
author: Tucker, JA
author: Breed, J
author: McCall, EJ
author: Minshull, CA
author: Timms, D
author: Pauptit, RA
author: McMiken, HH
db: Pubmed
title: Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor
source: Structure 12:75-84
year: 2004

UnificationXref97
type: UnificationXref
id: CHEBI:17659
db: ChEBI

UnificationXref96
type: UnificationXref
id: REACT_26828
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26828.2

UnificationXref99
type: UnificationXref
id: REACT_26764
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26764.1

UnificationXref98
type: UnificationXref
id: 205687
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=205687

RelationshipXref198
type: RelationshipXref
id: GO:0003990
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref199
type: RelationshipXref
id: 4234863
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234863

RelationshipXref195
type: RelationshipXref
id: GO:0006654
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref194
type: RelationshipXref
id: 4235531
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235531

RelationshipXref197
type: RelationshipXref
id: GO:0036155
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref90
type: UnificationXref
id: O53538
db: UniProt

RelationshipXref196
type: RelationshipXref
id: 4235525
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235525

UnificationXref91
type: UnificationXref
id: MOD:00163
db: MOD

RelationshipXref191
type: RelationshipXref
id: GO:0006702
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref92
type: UnificationXref
id: 4235268
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235268

RelationshipXref190
type: RelationshipXref
id: 4234614
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234614

UnificationXref93
type: UnificationXref
id: GO:0005796
db: GENE ONTOLOGY

RelationshipXref193
type: RelationshipXref
id: 4235536
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235536

UnificationXref94
type: UnificationXref
id: CHEBI:16264
db: ChEBI

RelationshipXref192
type: RelationshipXref
id: GO:0008202
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref95
type: UnificationXref
id: 914003
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=914003

UnificationXref2918
type: UnificationXref
id: 389843
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389843

UnificationXref2917
type: UnificationXref
id: REACT_2530
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2530.1

UnificationXref2919
type: UnificationXref
id: REACT_17198
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17198.1

RelationshipXref146
type: RelationshipXref
id: 4234999
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234999

UnificationXref2930
type: UnificationXref
id: 389822
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389822

RelationshipXref145
type: RelationshipXref
id: GO:0070251
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref144
type: RelationshipXref
id: 4234995
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234995

UnificationXref89
type: UnificationXref
id: REACT_142830
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142830.5

RelationshipXref143
type: RelationshipXref
id: GO:0016830
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref87
type: UnificationXref
id: REACT_147490
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147490.5

RelationshipXref149
type: RelationshipXref
id: 4234577
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234577

UnificationXref88
type: UnificationXref
id: 4236291
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236291

RelationshipXref148
type: RelationshipXref
id: GO:0008111
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref85
type: UnificationXref
id: REACT_145382
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145382.5

RelationshipXref147
type: RelationshipXref
id: GO:0001561
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref86
type: UnificationXref
id: 4236290
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236290

UnificationXref2938
type: UnificationXref
id: 4235014
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235014

http://identifiers.org/pubmed/17956727
type: PublicationXref
id: 17956727
author: Tseng, YH
author: Kahn, CR
author: Gesta, S
db: Pubmed
title: Developmental origin of fat: tracking obesity to its source
source: Cell 131:242-56
year: 2007

UnificationXref2937
type: UnificationXref
id: 4235013
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235013

UnificationXref2936
type: UnificationXref
id: P95143
db: UniProt

UnificationXref2935
type: UnificationXref
id: 4235010
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235010

UnificationXref2934
type: UnificationXref
id: P95040
db: UniProt

UnificationXref2933
type: UnificationXref
id: REACT_17855
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17855.2

UnificationXref2932
type: UnificationXref
id: 389864
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389864

UnificationXref2931
type: UnificationXref
id: REACT_17366
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17366.1

UnificationXref2928
type: UnificationXref
id: REACT_115360
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115360.8

UnificationXref2929
type: UnificationXref
id: CHEBI:17497
db: ChEBI

UnificationXref84
type: UnificationXref
id: 4236289
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236289

http://identifiers.org/pubmed/224930
type: PublicationXref
id: 224930
author: Inoue, K
author: Yamasawa, K
author: Nishimukai, H
db: Pubmed
title: Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes.
source: Biochim Biophys Acta 569:117-23
year: 1979

UnificationXref83
type: UnificationXref
id: REACT_130281
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130281.5

UnificationXref82
type: UnificationXref
id: 4236297
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236297

UnificationXref81
type: UnificationXref
id: REACT_146486
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146486.5

RelationshipXref141
type: RelationshipXref
id: GO:0050197
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref80
type: UnificationXref
id: 4235209
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235209

http://identifiers.org/pubmed/18436705
type: PublicationXref
id: 18436705
author: Scheuner, D
author: Kaufman, RJ
db: Pubmed
title: The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes
source: Endocr Rev 29:317-33
year: 2008

RelationshipXref142
type: RelationshipXref
id: 4234997
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234997

RelationshipXref140
type: RelationshipXref
id: GO:0044255
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref78
type: UnificationXref
id: O05898
db: UniProt

RelationshipXref133
type: RelationshipXref
id: GO:0046951
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref79
type: UnificationXref
id: 4235207
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235207

RelationshipXref132
type: RelationshipXref
id: 4233761
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233761

RelationshipXref135
type: RelationshipXref
id: 4234014
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234014

UnificationXref2941
type: UnificationXref
id: 4235018
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235018

RelationshipXref134
type: RelationshipXref
id: GO:0008260
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2940
type: UnificationXref
id: 4235016
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235016

http://identifiers.org/pubmed/22108505
type: PublicationXref
id: 22108505
author: Basler, Konrad
author: Herr, Patrick
db: Pubmed
title: Porcupine-mediated lipidation is required for Wnt recognition by Wls
source: Dev. Biol. 361:392-402
year: 2012

UnificationXref74
type: UnificationXref
id: REACT_153666
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153666.3

RelationshipXref137
type: RelationshipXref
id: GO:0046950
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref75
type: UnificationXref
id: CHEBI:17369
db: ChEBI

RelationshipXref136
type: RelationshipXref
id: GO:0046952
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref139
type: RelationshipXref
id: 4234520
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234520

UnificationXref76
type: UnificationXref
id: 532562
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=532562

RelationshipXref138
type: RelationshipXref
id: GO:0004368
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref77
type: UnificationXref
id: REACT_22559
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22559.2

UnificationXref2947
type: UnificationXref
id: REACT_113242
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113242.8

cysE
type: ProteinReference
name: UniProt:P95231 cysE
name: Rv2335
xref: UnificationXref5239
comment: CATALYTIC ACTIVITY Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.PATHWAY Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.DISRUPTION PHENOTYPE Strains lacking this gene are shown to be attenuated in a mouse tuberculosis model.MISCELLANEOUS Was identified as a high-confidence drug target.SIMILARITY Belongs to the transferase hexapeptide repeat family.
organism: BioSource1

UnificationXref2946
type: UnificationXref
id: 4235020
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235020

UnificationXref2949
type: UnificationXref
id: REACT_115484
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115484.8

UnificationXref2948
type: UnificationXref
id: 4236243
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236243

UnificationXref2943
type: UnificationXref
id: CHEBI:16995
db: ChEBI

UnificationXref2942
type: UnificationXref
id: REACT_112171
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112171.8

UnificationXref2945
type: UnificationXref
id: REACT_18181
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18181.2

http://identifiers.org/pubmed/18757502
type: PublicationXref
id: 18757502
author: Kulik, W
author: Visser, WF
author: Boek, M
author: van Cruchten, A
author: van Roermund, CW
author: Waterham, HR
author: IJlst, L
author: Wanders, RJ
db: Pubmed
title: The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters
source: FASEB J 22:4201-8
year: 2008

UnificationXref2944
type: UnificationXref
id: 389819
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389819

UnificationXref2939
type: UnificationXref
id: 4235015
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235015

http://identifiers.org/pubmed/9296496
type: PublicationXref
id: 9296496
author: Simon, MI
author: Hu, YH
author: Toombs, CF
author: Offermanns, S
db: Pubmed
title: Defective platelet activation in G alpha(q)-deficient mice
source: Nature 389:183-6
year: 1997

UnificationXref71
type: UnificationXref
id: 4235137
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235137

UnificationXref70
type: UnificationXref
id: 4235135
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235135

UnificationXref73
type: UnificationXref
id: 4236288
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236288

UnificationXref72
type: UnificationXref
id: REACT_159674
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159674.3

RelationshipXref130
type: RelationshipXref
id: GO:0019626
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref131
type: RelationshipXref
id: GO:0003985
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref65
type: UnificationXref
id: 449701
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=449701

UnificationXref66
type: UnificationXref
id: REACT_22935
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22935.2

Antigen processing: Ubiquitination & Proteasome degradation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction384
evidence: Evidence690
xref: RelationshipXref626
xref: UnificationXref4560
xref: UnificationXref4559
pathway order: PathwayStep674
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref63
type: UnificationXref
id: REACT_4309
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4309.3

RelationshipXref169
type: RelationshipXref
id: GO:0050614
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref64
type: UnificationXref
id: CHEBI:15873
db: ChEBI

RelationshipXref168
type: RelationshipXref
id: 4234653
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234653

UnificationXref69
type: UnificationXref
id: 4235134
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235134

UnificationXref2952
type: UnificationXref
id: REACT_2842
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2842.2

RelationshipXref167
type: RelationshipXref
id: GO:0008398
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2951
type: UnificationXref
id: 29804
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29804

RelationshipXref166
type: RelationshipXref
id: 4234560
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234560

UnificationXref67
type: UnificationXref
id: P0A588
db: UniProt

UnificationXref2950
type: UnificationXref
id: CHEBI:29103
db: ChEBI

RelationshipXref165
type: RelationshipXref
id: GO:0004452
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref68
type: UnificationXref
id: 4235133
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235133

UnificationXref2956
type: UnificationXref
id: 4234496
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234496

UnificationXref2955
type: UnificationXref
id: 4234495
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234495

UnificationXref2954
type: UnificationXref
id: 4234494
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234494

UnificationXref2953
type: UnificationXref
id: P77899
db: UniProt

UnificationXref2959
type: UnificationXref
id: 4234497
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234497

UnificationXref2958
type: UnificationXref
id: 4234500
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234500

UnificationXref2957
type: UnificationXref
id: P96871
db: UniProt

RelationshipXref163
type: RelationshipXref
id: 4234987
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234987

http://identifiers.org/pubmed/15845354
type: PublicationXref
id: 15845354
author: Okino, N
author: Tani, M
author: Nakagawa, T
author: Hwang, YH
author: Ito, M
db: Pubmed
title: Subcellular localization of human neutral ceramidase expressed in HEK293 cells
source: Biochem Biophys Res Commun 331:37-42
year: 2005

RelationshipXref164
type: RelationshipXref
id: GO:0006740
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref161
type: RelationshipXref
id: GO:0008611
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref162
type: RelationshipXref
id: GO:0004450
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref62
type: UnificationXref
id: 29404
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29404

RelationshipXref160
type: RelationshipXref
id: 4235027
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235027

UnificationXref61
type: UnificationXref
id: CHEBI:16015
db: ChEBI

UnificationXref60
type: UnificationXref
id: REACT_2663
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2663.2

RelationshipXref159
type: RelationshipXref
id: GO:0008609
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref52
type: UnificationXref
id: 4236334
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236334

RelationshipXref158
type: RelationshipXref
id: 4234150
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234150

UnificationXref53
type: UnificationXref
id: REACT_146399
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146399.5

UnificationXref54
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

http://identifiers.org/pubmed/22983114
type: PublicationXref
id: 22983114
author: Boutros, Michael
author: Bartscherer, Kerstin
author: Chaudhary, Varun
author: Gross, Julia Christina
db: Pubmed
title: Active Wnt proteins are secreted on exosomes
source: Nat. Cell Biol. 14:1036-45
year: 2012

UnificationXref55
type: UnificationXref
id: CHEBI:18050
db: ChEBI

RelationshipXref155
type: RelationshipXref
id: GO:0005325
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref56
type: UnificationXref
id: 29472
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29472

UnificationXref2961
type: UnificationXref
id: 4234502
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234502

RelationshipXref154
type: RelationshipXref
id: GO:0033540
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref57
type: UnificationXref
id: REACT_2473
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2473.2

UnificationXref2960
type: UnificationXref
id: 4234501
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234501

RelationshipXref157
type: RelationshipXref
id: GO:0016287
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref58
type: UnificationXref
id: CHEBI:15946
db: ChEBI

UnificationXref2963
type: UnificationXref
id: REACT_77766
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77766.9

RelationshipXref156
type: RelationshipXref
id: 4235025
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235025

UnificationXref59
type: UnificationXref
id: 29512
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29512

UnificationXref2962
type: UnificationXref
id: 4234504
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234504

UnificationXref2965
type: UnificationXref
id: 174369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174369

UnificationXref2964
type: UnificationXref
id: CHEBI:17230
db: ChEBI

UnificationXref2967
type: UnificationXref
id: CHEBI:17482
db: ChEBI

UnificationXref2966
type: UnificationXref
id: REACT_7731
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7731.2

UnificationXref2969
type: UnificationXref
id: REACT_116259
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116259.1

UnificationXref2968
type: UnificationXref
id: 1614518
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614518

UniProt:P95208
type: ProteinReference
xref: UnificationXref2800
organism: BioSource1

RelationshipXref150
type: RelationshipXref
id: GO:0050632
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref151
type: RelationshipXref
id: 4234591
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234591

RelationshipXref152
type: RelationshipXref
id: GO:0003986
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref153
type: RelationshipXref
id: 4235023
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235023

UnificationXref51
type: UnificationXref
id: REACT_136675
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136675.5

UnificationXref50
type: UnificationXref
id: 4236333
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236333

http://identifiers.org/pubmed/12800216
type: PublicationXref
id: 12800216
author: Zhang, M
author: Zhu, F
db: Pubmed
title: DNA polymerase zeta: new insight into eukaryotic mutagenesis and mammalian embryonic development.
source: World J Gastroenterol 9:1165-9
year: 2003

http://identifiers.org/pubmed/20153287
type: PublicationXref
id: 20153287
author: Wallace, J C
author: Bailey, L M
author: Polyak, S W
db: Pubmed
title: Holocarboxylase synthetase: correlation of protein localisation with biological function
source: Arch. Biochem. Biophys. 496:45-52
year: 2010

http://identifiers.org/pubmed/3624221
type: PublicationXref
id: 3624221
author: Mechanic, GL
author: Yamauchi, M
author: Hashimoto, F
author: London, RE
author: Guenat, C
db: Pubmed
title: Structure and formation of a stable histidine-based trifunctional cross-link in skin collagen
source: J Biol Chem 262:11428-34
year: 1987

Base Excision Repair
type: Pathway
data source: Provenance1
pathway component: REACT 81409.9
evidence: Evidence620
xref: UnificationXref4215
xref: RelationshipXref575
xref: UnificationXref4216
pathway order: PathwayStep606
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11851336
type: PublicationXref
id: 11851336
author: Swain, A
author: Dunten, P
author: Crowther, R
author: Kammlott, U
author: Wertheimer, SJ
author: Michel, H
author: Weber, D
author: Ramsey, GB
author: Levin, W
author: Belunis, C
author: Hollfelder, K
db: Pubmed
title: Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site
source: J Mol Biol 316:257-264
year: 2002

UnificationXref15
type: UnificationXref
id: REACT_134831
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134831.5

RelationshipXref112
type: RelationshipXref
id: 4234200
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234200

UnificationXref14
type: UnificationXref
id: 4236298
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236298

RelationshipXref113
type: RelationshipXref
id: GO:0050633
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref13
type: UnificationXref
id: ECO:0000203
db: EVIDENCE CODE

RelationshipXref110
type: RelationshipXref
id: 4234198
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234198

UnificationXref12
type: UnificationXref
id: REACT_126802
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126802.5

RelationshipXref111
type: RelationshipXref
id: GO:0003857
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref11
type: UnificationXref
id: 4235214
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235214

RelationshipXref116
type: RelationshipXref
id: 4234186
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234186

UnificationXref10
type: UnificationXref
id: 4235213
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235213

RelationshipXref117
type: RelationshipXref
id: 4234180
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234180

RelationshipXref114
type: RelationshipXref
id: 4234195
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234195

RelationshipXref115
type: RelationshipXref
id: GO:0006635
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref118
type: RelationshipXref
id: 4234226
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234226

RelationshipXref119
type: RelationshipXref
id: 4234215
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234215

UnificationXref19
type: UnificationXref
id: 4236299
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236299

UnificationXref18
type: UnificationXref
id: REACT_139138
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139138.5

UnificationXref17
type: UnificationXref
id: 4236301
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236301

UnificationXref16
type: UnificationXref
id: MI:0359
db: MI

RelationshipXref120
type: RelationshipXref
id: GO:0004165
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref24
type: UnificationXref
id: 4229744
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229744

RelationshipXref121
type: RelationshipXref
id: 4234235
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234235

UnificationXref2993
type: UnificationXref
id: REACT_76013
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_76013.2

UnificationXref23
type: UnificationXref
id: 4229743
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229743

RelationshipXref122
type: RelationshipXref
id: GO:0016651
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2994
type: UnificationXref
id: O53227
db: UniProt

UnificationXref26
type: UnificationXref
id: 4233557
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233557

RelationshipXref123
type: RelationshipXref
id: 4234248
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234248

UnificationXref2995
type: UnificationXref
id: 4235430
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235430

UnificationXref25
type: UnificationXref
id: P95096
db: UniProt

RelationshipXref124
type: RelationshipXref
id: GO:0016860
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2996
type: UnificationXref
id: 4235431
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235431

UnificationXref20
type: UnificationXref
id: REACT_141681
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141681.5

RelationshipXref125
type: RelationshipXref
id: 4234251
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234251

RelationshipXref126
type: RelationshipXref
id: GO:0004493
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2990
type: UnificationXref
id: REACT_126207
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126207.5

UnificationXref22
type: UnificationXref
id: REACT_126788
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126788.5

RelationshipXref127
type: RelationshipXref
id: 4233813
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233813

UnificationXref2991
type: UnificationXref
id: CHEBI:4047
db: ChEBI

UnificationXref21
type: UnificationXref
id: 4236300
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236300

RelationshipXref128
type: RelationshipXref
id: GO:0004494
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2992
type: UnificationXref
id: 1247904
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1247904

RelationshipXref129
type: RelationshipXref
id: 4233808
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233808

ChEBI:28477 7alpha,12alpha-dihydroxycholest-4-en-3-one
type: SmallMoleculeReference
name: 7alpha,12alpha-dihydroxycholest-4-en-3-one
xref: UnificationXref1290

UnificationXref28
type: UnificationXref
id: 4233559
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233559

UnificationXref2997
type: UnificationXref
id: 4235433
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235433

UnificationXref27
type: UnificationXref
id: MI:0355
db: MI

UnificationXref2998
type: UnificationXref
id: REACT_128025
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128025.5

Processive synthesis on the lagging strand
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1
evidence: Evidence7
xref: UnificationXref30
xref: UnificationXref31
pathway order: PathwayStep6
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2999
type: UnificationXref
id: CHEBI:16136
db: ChEBI

UnificationXref29
type: UnificationXref
id: REACT_109434
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_109434.9

formamidopyrimidine
type: SmallMoleculeReference
name: 5-formamidopyrimidine
name: ChEBI:35877 5-formamidopyrimidine
xref: UnificationXref4204

UnificationXref33
type: UnificationXref
id: REACT_94714
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94714.9

UnificationXref2980
type: UnificationXref
id: REACT_7424
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7424.3

UnificationXref32
type: UnificationXref
id: 4236050
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236050

UnificationXref2981
type: UnificationXref
id: CHEBI:30831
db: ChEBI

UnificationXref31
type: UnificationXref
id: REACT_77324
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77324.9

UnificationXref30
type: UnificationXref
id: 4236049
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236049

http://identifiers.org/pubmed/19783045
type: PublicationXref
id: 19783045
author: Kongsuphol, Patthara
author: Kunzelmann, Karl
author: Schreiber, Rainer
author: Warth, R
author: Tian, Yuemin
author: Ousingsawat, Jiraporn
author: Aldehni, Fadi
db: Pubmed
title: Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions
source: Cell Calcium 46:233-41
year: 2009

UnificationXref37
type: UnificationXref
id: REACT_98399
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98399.9

UnificationXref2984
type: UnificationXref
id: P66875
db: UniProt

UnificationXref36
type: UnificationXref
id: 4236052
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236052

UnificationXref2985
type: UnificationXref
id: 4235573
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235573

UnificationXref35
type: UnificationXref
id: REACT_85176
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85176.9

UnificationXref2982
type: UnificationXref
id: 936714
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936714

UnificationXref34
type: UnificationXref
id: 4236051
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236051

UnificationXref2983
type: UnificationXref
id: REACT_27614
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27614.3

UnificationXref2988
type: UnificationXref
id: REACT_141843
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141843.5

UnificationXref2989
type: UnificationXref
id: 4236335
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236335

UnificationXref39
type: UnificationXref
id: REACT_32013
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32013.10

UnificationXref2986
type: UnificationXref
id: 4235574
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235574

http://identifiers.org/pubmed/3893466
type: PublicationXref
id: 3893466
author: Jornvall, H
db: Pubmed
title: Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes
source: Alcohol 2:61-6
year: 1985

UnificationXref38
type: UnificationXref
id: 4236053
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236053

UnificationXref2987
type: UnificationXref
id: 4235579
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235579

http://identifiers.org/pubmed/21238944
type: PublicationXref
id: 21238944
author: Rath, P
author: Shi, S
author: Ehrt, S
author: Venugopal, A
author: Schnappinger, D
author: Bryk, R
author: Rhee, K
author: Nathan, C
db: Pubmed
title: Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes
source: Cell Host Microbe 9:21-31
year: 2011

UnificationXref40
type: UnificationXref
id: 4236054
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236054

UnificationXref42
type: UnificationXref
id: 4236055
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236055

RelationshipXref103
type: RelationshipXref
id: 4234163
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234163

Decanoyl-CoA
type: SmallMoleculeReference
name: Decanoyl-CoA [ChEBI:28493]
xref: UnificationXref849

UnificationXref41
type: UnificationXref
id: REACT_98208
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98208.9

RelationshipXref104
type: RelationshipXref
id: GO:0003841
db: GENE ONTOLOGY
relationship type: MI:0355

Diphosphatidylglycerol
type: SmallMoleculeReference
name: cardiolipin
name: cardiolipin [ChEBI:28494]
name: cardiolipins
name: 1',3'-Bis(1,2-diacyl-sn-glycero-3-phospho)-sn-glycerol
xref: UnificationXref1541

UnificationXref44
type: UnificationXref
id: P95060
db: UniProt

RelationshipXref105
type: RelationshipXref
id: 4234157
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234157

UnificationXref43
type: UnificationXref
id: REACT_118154
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118154.7

RelationshipXref106
type: RelationshipXref
id: GO:0019432
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2970
type: UnificationXref
id: CHEBI:17627
db: ChEBI

UnificationXref46
type: UnificationXref
id: 4235561
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235561

UnificationXref2971
type: UnificationXref
id: 71185
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71185

UnificationXref45
type: UnificationXref
id: 4235562
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235562

RelationshipXref100
type: RelationshipXref
id: GO:0004370
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2972
type: UnificationXref
id: REACT_2784
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2784.3

UnificationXref48
type: UnificationXref
id: 4235564
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235564

RelationshipXref101
type: RelationshipXref
id: 4234168
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234168

UnificationXref2973
type: UnificationXref
id: Q7D8W0
db: UniProt

http://identifiers.org/pubmed/8662720
type: PublicationXref
id: 8662720
author: Korenberg, J
author: Garrow, TA
author: Qi, H
author: Choi, YJ
author: Shane, B
author: Chen, L
db: Pubmed
title: Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
source: J Biol Chem 271:13077-87
year: 1996

UnificationXref47
type: UnificationXref
id: 4235563
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235563

RelationshipXref102
type: RelationshipXref
id: GO:0004366
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2974
type: UnificationXref
id: 4235568
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235568

UnificationXref2975
type: UnificationXref
id: 4235569
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235569

UnificationXref49
type: UnificationXref
id: REACT_141825
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141825.5

UnificationXref2976
type: UnificationXref
id: 4235571
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235571

UnificationXref2977
type: UnificationXref
id: REACT_135563
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135563.5

UnificationXref2978
type: UnificationXref
id: CHEBI:17561
db: ChEBI

RelationshipXref107
type: RelationshipXref
id: GO:0003995
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2979
type: UnificationXref
id: 111707
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111707

RelationshipXref108
type: RelationshipXref
id: 4234206
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234206

RelationshipXref109
type: RelationshipXref
id: GO:0004300
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/14500886
type: PublicationXref
id: 14500886
author: Green, S
author: Warrington, JA
author: Davis, S
author: Wolfe, CL
author: Norcum, MT
db: Pubmed
title: Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII
source: Protein Sci 12:2282-90
year: 2003

http://identifiers.org/pubmed/10049780
type: PublicationXref
id: 10049780
author: Sukhatme, VP
author: Segal, M
author: Ramchandran, R
author: Volk, R
author: Waterman, MJ
author: Lu, H
author: Dhanabal, M
author: Knebelmann, B
db: Pubmed
title: Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin
source: Biochem Biophys Res Commun 255:735-9
year: 1999

http://identifiers.org/pubmed/19945617
type: PublicationXref
id: 19945617
author: Kern, Johannes S
author: Has, Cristina
db: Pubmed
title: Collagen XVII
source: Dermatol Clin 28:61-6
year: 2010

http://identifiers.org/pubmed/16435184
type: PublicationXref
id: 16435184
author: Ten Brink, HJ
author: Jakobs, C
author: Gibson, KM
author: Verhoeven, NM
author: Struys, EA
author: Wickenhagen, WV
db: Pubmed
title: Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias
source: J Inherit Metab Dis 28:921-30
year: 2005

http://identifiers.org/pubmed/11604561
type: PublicationXref
id: 11604561
author: Cattaneo, M
author: Ruggeri, ZM
author: Savage, B
db: Pubmed
title: Mechanisms of platelet aggregation
source: Curr Opin Hematol 8:270-6
year: 2001

Homologous recombination repair of replication-independent double-strand breaks
type: Pathway
data source: Provenance1
pathway component: Resolution of D-loop structures
evidence: Evidence645
xref: UnificationXref4309
xref: UnificationXref4308
pathway order: PathwayStep631
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/12397064
type: PublicationXref
id: 12397064
author: Ren, Y
author: Schulz, H
db: Pubmed
title: Metabolic functions of the two pathways of oleate beta-oxidation double bond metabolism during the beta-oxidation of oleic acid in rat heart mitochondria
source: J Biol Chem 278:111-6
year: 2003

http://identifiers.org/pubmed/16746585
type: PublicationXref
id: 16746585
author: Salvin, E
author: Johnson, WA
author: Krebs, HA
db: Pubmed
title: The formation of citric and alpha-ketoglutaric acids in the mammalian body
source: Biochem J 32:113-117
year: 1938

http://identifiers.org/pubmed/19489725
type: PublicationXref
id: 19489725
author: Joazeiro, CA
author: Deshaies, RJ
db: Pubmed
title: RING domain E3 ubiquitin ligases
source: Annu Rev Biochem 78:399-434
year: 2009

http://identifiers.org/pubmed/8896562
type: PublicationXref
id: 8896562
author: Saarialho-Kere, U
author: Haila, S
author: Kere, J
author: de la Chapelle, A
author: Socha, J
author: Karjalainen-Lindsberg, ML
author: Airola, K
author: Höglund, P
author: Tomaszewski, L
author: Holmberg, C
db: Pubmed
title: Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea
source: Nat Genet 14:316-9
year: 1996

http://identifiers.org/pubmed/8618861
type: PublicationXref
id: 8618861
author: Nevins, JR
author: DeGregori, J
author: Ohtani, K
db: Pubmed
title: Regulation of the cyclin E gene by transcription factor E2F1
source: Proc Natl Acad Sci U S A 92:12146-50
year: 1995

http://identifiers.org/pubmed/11481338
type: PublicationXref
id: 11481338
author: Bobik, TA
author: Rasche, ME
db: Pubmed
title: Identification of the human methylmalonyl-CoA racemase gene based on the analysis of prokaryotic gene arrangements. Implications for decoding the human genome.
source: J Biol Chem 276:37194-8
year: 2001

http://identifiers.org/pubmed/19945621
type: PublicationXref
id: 19945621
author: Uitto, J
author: Chung, HJ
db: Pubmed
title: Type VII collagen: the anchoring fibril protein at fault in dystrophic epidermolysis bullosa
source: Dermatol Clin 28:93-105
year: 2010

http://identifiers.org/pubmed/9461603
type: PublicationXref
id: 9461603
author: Aguado, B
author: Campbell, RD
db: Pubmed
title: Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex
source: J Biol Chem 273:4096-105
year: 1998

http://identifiers.org/pubmed/11051212
type: PublicationXref
id: 11051212
author: Szkopinska, A
db: Pubmed
title: Ubiquinone. Biosynthesis of quinone ring and its isoprenoid side chain. Intracellular localization
source: Acta Biochim Pol 47:469-80
year: 2000

http://identifiers.org/pubmed/18043707
type: PublicationXref
id: 18043707
author: Hamm, HE
author: Oldham, WM
db: Pubmed
title: Heterotrimeric G protein activation by G-protein-coupled receptors
source: Nat Rev Mol Cell Biol 9:60-71
year: 2008

MPS IIIA - Sanfilippo syndrome A
type: Pathway
data source: Provenance1
pathway component: REACT 134911.5
evidence: Evidence505
xref: UnificationXref3525
xref: UnificationXref3524
pathway order: PathwayStep84
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Transport of inorganic cations/anions and amino acids/oligopeptides
type: Pathway
data source: Provenance1
pathway component: REACT 97870.9
pathway component: REACT 80676.9
pathway component: Amino acid transport across the plasma membrane
pathway component: REACT 112147.8
evidence: Evidence672
xref: UnificationXref4456
xref: RelationshipXref610
xref: UnificationXref4455
pathway order: PathwayStep520
pathway order: PathwayStep657
pathway order: PathwayStep655
pathway order: PathwayStep652
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/8617764
type: PublicationXref
id: 8617764
author: Cheresh, DA
author: Ramirez, F
author: Broekelmann, T
author: Mecham, RP
author: Rosenbloom, J
author: Sakamoto, H
db: Pubmed
title: Cell-type specific recognition of RGD- and non-RGD-containing cell binding domains in fibrillin-1
source: J Biol Chem 271:4916-22
year: 1996

http://identifiers.org/pubmed/5940
type: PublicationXref
id: 5940
author: Povey, S
author: Wilson, Jr, DE
author: Harris, H
db: Pubmed
title: Adenylate kinases in man: evidence for a third locus
source: Ann Hum Genet 39:305-313
year: 1976

3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA
type: SmallMoleculeReference
name: ChEBI:27379 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA
xref: UnificationXref1337

Glyoxylate metabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction256
pathway component: BiochemicalReaction258
pathway component: BiochemicalReaction257
evidence: Evidence418
xref: UnificationXref2948
xref: UnificationXref2949
xref: RelationshipXref435
pathway order: PathwayStep415
pathway order: PathwayStep413
pathway order: PathwayStep414
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/5666113
type: PublicationXref
id: 5666113
author: Luzzatto, L
author: Afolayan, A
db: Pubmed
title: Enzymic properties of different types of human erythrocyte glucose-6-phosphate dehydrogenase, with characterization of two new genetic variants
source: J Clin Invest 47:1833-42
year: 1968

http://identifiers.org/pubmed/17186029
type: PublicationXref
id: 17186029
author: Mariathasan, S
author: Monack, DM
db: Pubmed
title: Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
source: Nat Rev Immunol 7:31-40
year: 2007

http://identifiers.org/pubmed/13934211
type: PublicationXref
id: 13934211
author: Sasakawa, T
author: Mazumder, R
author: Ochoa, S
author: Kaziro, Y
db: Pubmed
title: Metabolism of propionic acid in animal tissues. IX. Methylmalonyl coenzyme A racemase
source: J Biol Chem 237:3065-8
year: 1962

http://identifiers.org/pubmed/8380692
type: PublicationXref
id: 8380692
author: Itakura, M
author: Kudo, E
author: Yoshimoto, K
author: Mizusawa, N
author: Holmes, EW
author: Ii, S
author: Oka, J
author: Iwahana, H
db: Pubmed
title: Molecular cloning of human amidophosphoribosyltransferase
source: Biochem Biophys Res Commun 190:192-200
year: 1993

Proline catabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction248
evidence: Evidence401
xref: RelationshipXref411
xref: UnificationXref2828
xref: UnificationXref2827
pathway order: PathwayStep398
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11331907
type: PublicationXref
id: 11331907
author: Irvine, RF
author: Schell, MJ
db: Pubmed
title: Back in the water: the return of the inositol phosphates
source: Nat Rev Mol Cell Biol 2:327-38
year: 2001

(24S)-24-hydroxycholesterol
type: SmallMoleculeReference
name: ChEBI:34310 (24S)-24-hydroxycholesterol
xref: UnificationXref1377

http://identifiers.org/pubmed/17558559
type: PublicationXref
id: 17558559
author: Ghosh, D
db: Pubmed
title: Human sulfatases: a structural perspective to catalysis
source: Cell Mol Life Sci 64:2013-22
year: 2007

Assembly of collagen fibrils and other multimeric structures
type: Pathway
data source: Provenance1
pathway component: Anchoring fibril formation
evidence: Evidence589
xref: UnificationXref4087
xref: UnificationXref4088
pathway order: PathwayStep576
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/21554866
type: PublicationXref
id: 21554866
author: Cox, Brian J
author: Biechele, Steffen
author: Rossant, Janet
db: Pubmed
title: Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos
source: Dev. Biol. 355:275-85
year: 2011

http://identifiers.org/pubmed/3609327
type: PublicationXref
id: 3609327
author: Apon, S
author: Walsh, KA
author: Eyre, DR
author: Wu, JJ
author: Ericsson, LH
db: Pubmed
title: Collagen type IX: evidence for covalent linkages to type II collagen in cartilage
source: FEBS Lett 220:337-41
year: 1987

Arachidonate production from DAG
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction312
evidence: Evidence557
xref: UnificationXref3731
xref: UnificationXref3732
pathway order: PathwayStep548
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

alvespimycin [ChEBI:65324]
type: SmallMoleculeReference
name: alvespimycin
xref: UnificationXref3491

http://identifiers.org/pubmed/16174769
type: PublicationXref
id: 16174769
author: Chen, Y
author: Pfeifer, GP
author: Jin, SG
author: O'Connor, TR
author: Cai, S
author: Lee, DH
db: Pubmed
title: Repair of methylation damage in DNA and RNA by mammalian AlkB homologues
source: J Biol Chem 280:39448-59
year: 2005

http://identifiers.org/pubmed/17698287
type: PublicationXref
id: 17698287
author: Grabowska, AM
author: Watson, SA
db: Pubmed
title: Role of gastrin peptides in carcinogenesis
source: Cancer Lett 257:1-15
year: 2007

http://identifiers.org/pubmed/8089153
type: PublicationXref
id: 8089153
author: Hirst, M
author: Lou, L
author: Nakamura, J
author: Haliday, E
db: Pubmed
title: Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA
source: J Biol Chem 269:23830-23837
year: 1994

http://identifiers.org/pubmed/14729598
type: PublicationXref
id: 14729598
author: Zhou, B
author: Shao, J
author: Zhu, L
author: Yen, Y
author: Qiu, W
author: Xi, B
author: Yuan, YC
db: Pubmed
title: In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase
source: Cancer Res 64:1-6
year: 2004

http://identifiers.org/pubmed/16405877
type: PublicationXref
id: 16405877
author: Visse, R
author: Murphy, G
author: Nagase, H
db: Pubmed
title: Structure and function of matrix metalloproteinases and TIMPs
source: Cardiovasc Res 69:562-73
year: 2006

Pyruvate
type: SmallMoleculeReference
name: Pyruvic acid
name: Pyroracemic acid
name: 2-Oxopropanoate
name: 2-Oxopropanoic acid
name: Pyruvate [ChEBI:32816]
xref: UnificationXref248

http://identifiers.org/pubmed/16807922
type: PublicationXref
id: 16807922
author: Hu, WS
author: Lee, MM
author: Hossler, P
author: Goh, LT
db: Pubmed
title: GlycoVis: visualizing glycan distribution in the protein N-glycosylation pathway in mammalian cells
source: Biotechnol Bioeng 95:946-60
year: 2006

http://identifiers.org/pubmed/19261609
type: PublicationXref
id: 19261609
author: Vitvitsky, V
author: Singh, S
author: Banerjee, R
author: Zhu, W
author: Chiku, T
author: Padovani, D
db: Pubmed
title: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia
source: J Biol Chem 284:11601-12
year: 2009

http://identifiers.org/pubmed/8428657
type: PublicationXref
id: 8428657
author: Yang, DC
author: Donovan, D
author: Vogeli, G
author: Vilalta, A
author: Wood, L
db: Pubmed
title: Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase
source: Gene 123:181-6
year: 1993

http://identifiers.org/pubmed/16024644
type: PublicationXref
id: 16024644
author: Shimamura, T
author: Shapiro, GI
author: Engelman, JA
author: Lowell, AM
db: Pubmed
title: Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
source: Cancer Res 65:6401-8
year: 2005

http://identifiers.org/pubmed/171650
type: PublicationXref
id: 171650
author: Harper, E
author: Byers, PH
author: Click, EM
author: Bornstein, P
db: Pubmed
title: Interchain disulfide bonds in procollagen are located in a large nontriple-helical COOH-terminal domain
source: Proc Natl Acad Sci U S A 72:3009-13
year: 1975

Purine catabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction175
pathway component: BiochemicalReaction176
evidence: Evidence305
xref: UnificationXref2069
xref: RelationshipXref287
xref: UnificationXref2070
pathway order: PathwayStep302
pathway order: PathwayStep301
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/16751282
type: PublicationXref
id: 16751282
author: Irving, TC
author: Orgel, JP
author: Miller, A
author: Wess, TJ
db: Pubmed
title: Microfibrillar structure of type I collagen in situ
source: Proc Natl Acad Sci U S A 103:9001-5
year: 2006

ChEBI:27403 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
type: SmallMoleculeReference
name: 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
xref: UnificationXref1402

(S)-3-Hydroxyhexadecanoyl-CoA [ChEBI:27402]
type: SmallMoleculeReference
name: (S)-3-Hydroxyhexadecanoyl-CoA
xref: UnificationXref778

http://identifiers.org/pubmed/10503886
type: PublicationXref
id: 10503886
author: Yoshinari, K
author: Fujita, K
author: Nagata, K
author: Shiraga, T
author: Yamazoe, Y
author: Iwasaki, K
db: Pubmed
title: Sulfotransferase catalyzing sulfation of heterocyclic amines
source: Cancer Lett 143:103-7
year: 1999

Mtb iron assimilation by chelation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction413
pathway component: BiochemicalReaction412
pathway component: BiochemicalReaction415
pathway component: BiochemicalReaction416
pathway component: BiochemicalReaction414
pathway component: BiochemicalReaction417
pathway component: BiochemicalReaction411
pathway component: BiochemicalReaction410
xref: RelationshipXref677
xref: http://identifiers.org/pubmed/17804665
xref: UnificationXref4939
xref: UnificationXref4940
pathway order: PathwayStep717
pathway order: PathwayStep720
pathway order: PathwayStep715
pathway order: PathwayStep719
pathway order: PathwayStep716
pathway order: PathwayStep718
pathway order: PathwayStep714
pathway order: PathwayStep713
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Uptake of iron in Mtb, especially when the bacterium is in the host, strongly depends on siderophores. Humans, through secretion of lactoferrin, maintain an iron concentration of 10^(-18) M within macrophages, and the bacterium has evolved the siderophores mycobactin T and exomycobactin T (formerly exochelin) to cope with this shortage. While nonpolar mycobactin T stays in the cell wall and only moves around in liquid droplets, polar exochelin is abundantly secreted. As it can bind iron with higher affinity than lactoferrin, it frequently scavenges iron ions from this molecule (Miethke & Marahiel 2007).
comment: Authored: Stephan, R, 2011-01-10
organism: BioSource1

3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
type: SmallMoleculeReference
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA [ChEBI:1701]
xref: UnificationXref1422

G alpha (i) signalling events
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction418
evidence: Evidence712
xref: UnificationXref4962
xref: UnificationXref4961
pathway order: PathwayStep729
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/18767960
type: PublicationXref
id: 18767960
author: Antonellis, A
author: Green, ED
db: Pubmed
title: The role of aminoacyl-tRNA synthetases in genetic diseases
source: Annu Rev Genomics Hum Genet 9:87-107
year: 2008

http://identifiers.org/pubmed/21511966
type: PublicationXref
id: 21511966
author: Beech, Cameron M
author: Shah, Nidhi P
author: Tanner, Stephan M
author: Sturm, Amy C
db: Pubmed
title: Investigation of the ABC transporter MRP1 in selected patients with presumed defects in vitamin B12 absorption
source: Blood 117:4397-8
year: 2011

http://identifiers.org/pubmed/2995985
type: PublicationXref
id: 2995985
author: Evans, DR
author: Kelly, RE
author: Pastra-Landis, SC
author: Lee, L
db: Pubmed
title: Oligomeric structure of the multifunctional protein CAD that initiates pyrimidine biosynthesis in mammalian cells
source: Proc Natl Acad Sci USA 82:6802-6806
year: 1985

http://identifiers.org/pubmed/18201392
type: PublicationXref
id: 18201392
author: Clarke, LA
db: Pubmed
title: The mucopolysaccharidoses: a success of molecular medicine
source: Expert Rev Mol Med 10:e1
year: 2008

http://identifiers.org/pubmed/12626396
type: PublicationXref
id: 12626396
author: Pastuszak, I
author: Pan, YT
author: Elbein, AD
author: Carroll, D
db: Pubmed
title: New insights on trehalose: a multifunctional molecule
source: Glycobiology 13:17R-27R
year: 2003

http://identifiers.org/pubmed/9438378
type: PublicationXref
id: 9438378
author: Shuttleworth, CA
db: Pubmed
title: Type VIII collagen
source: Int J Biochem Cell Biol 29:1145-8
year: 1997

http://identifiers.org/pubmed/1335363
type: PublicationXref
id: 1335363
author: Birnbaumer, L
db: Pubmed
title: Receptor-to-effector signaling through G proteins: roles for beta gamma dimers as well as alpha subunits
source: Cell 71:1069-72
year: 1992

http://identifiers.org/pubmed/1590793
type: PublicationXref
id: 1590793
author: Waltenberger, J
author: Usuki, K
author: Heldin, CH
author: Pierce, G
author: Thomason, A
author: Miyazono, K
author: Saras, J
db: Pubmed
title: Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.
source: Biochem Biophys Res Commun 184:1311-6
year: 1992

Stoichiometry9
type: Stoichiometry
physical entity: Protein24
stoichiometric coefficient: 2.0

Stoichiometry8
type: Stoichiometry
physical entity: Protein25
stoichiometric coefficient: 2.0

Stoichiometry1
type: Stoichiometry
physical entity: SUMF2_HUMAN
stoichiometric coefficient: 1.0

Stoichiometry3
type: Stoichiometry
physical entity: Protein23
stoichiometric coefficient: 2.0

http://identifiers.org/pubmed/8200987
type: PublicationXref
id: 8200987
author: Rabier, D
author: Poggi-Bach, J
author: Rötig, A
author: Munnich, A
author: Landrieu, P
author: Doonan, S
author: Letouzé, P
author: Rustin, P
author: Chretien, D
author: Bourgeron, T
db: Pubmed
title: Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency
source: J Clin Invest 93:2514-2518
year: 1994

Stoichiometry2
type: Stoichiometry
physical entity: Note: the coordinates are copied over from Homo sapiens.
stoichiometric coefficient: 1.0

Stoichiometry5
type: Stoichiometry
physical entity: Protein25
stoichiometric coefficient: 4.0

Stoichiometry4
type: Stoichiometry
physical entity: Protein24
stoichiometric coefficient: 4.0

Stoichiometry7
type: Stoichiometry
physical entity: Protein24
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/8114698
type: PublicationXref
id: 8114698
author: Nevins, JR
author: Ohtani, K
db: Pubmed
title: Functional properties of a Drosophila homolog of the E2F1 gene
source: Mol Cell Biol 14:1603-12
year: 1994

Stoichiometry6
type: Stoichiometry
physical entity: Protein25
stoichiometric coefficient: 3.0

http://identifiers.org/pubmed/1559981
type: PublicationXref
id: 1559981
author: Dupret, JM
author: Grant, DM
db: Pubmed
title: Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2.
source: J Biol Chem 267:7381-5
year: 1992

SequenceSite9
type: SequenceSite
position status: EQUAL
sequence position: 26

SequenceSite7
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite8
type: SequenceSite
position status: EQUAL
sequence position: 919

SequenceSite5
type: SequenceSite
position status: EQUAL
sequence position: 2

Rv1876
type: ProteinReference
name: UniProt:P63697
name: MTCY180.42c
name: bfr
name: bfrA
name: MT1925
xref: UnificationXref4921
comment: FUNCTION: May perform analogous functions in iron detoxification and storage to that of animal ferritins (By similarity).
organism: BioSource1

SequenceSite6
type: SequenceSite
position status: EQUAL
sequence position: 313

UniProt:P66926
type: ProteinReference
xref: UnificationXref1011
organism: BioSource1

SequenceSite2
type: SequenceSite
position status: EQUAL
sequence position: 389

SequenceSite1
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite4
type: SequenceSite
position status: EQUAL
sequence position: 389

SequenceSite3
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/1431593
type: PublicationXref
id: 1431593
author: Coates, PM
author: Tanaka, K
db: Pubmed
title: Molecular basis of mitochondrial fatty acid oxidation defects.
source: J Lipid Res 33:1099-110
year: 1992

http://identifiers.org/pubmed/15581364
type: PublicationXref
id: 15581364
author: Zhai, H
author: McLafferty, FW
author: Brand, LA
author: Begley, TP
author: Strauss, E
db: Pubmed
title: Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent
source: Biochemistry 43:15520-33
year: 2004

UniProt:P72007
type: ProteinReference
xref: UnificationXref1064
organism: BioSource1

PLC beta mediated events
type: Pathway
data source: Provenance1
pathway component: REACT 33160.10
evidence: Evidence717
xref: UnificationXref4971
xref: UnificationXref4972
pathway order: PathwayStep735
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10037775
type: PublicationXref
id: 10037775
author: Hu, CA
author: Valle, D
author: Obie, C
author: Lin, WW
db: Pubmed
title: Molecular enzymology of mammalian Delta1-pyrroline-5-carboxylate synthase. Alternative splice donor utilization generates isoforms with different sensitivity to ornithine inhibition
source: J Biol Chem 274:6754-62
year: 1999

UniProt:P72002
type: ProteinReference
xref: UnificationXref1250
organism: BioSource1

http://identifiers.org/pubmed/10522552
type: PublicationXref
id: 10522552
author: Ponka, P
db: Pubmed
title: Cell biology of heme
source: Am J Med Sci 318:241-56
year: 1999

http://identifiers.org/pubmed/16116451
type: PublicationXref
id: 16116451
author: Szabó, SI
author: Makara, JK
author: Fegley, D
author: Freund, TF
author: Tontini, A
author: Duranti, A
author: Mor, M
author: Astarita, G
author: Piomelli, D
author: Rivara, S
author: Tarzia, G
author: Kathuria, S
db: Pubmed
title: Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
source: Nat Neurosci 8:1139-41
year: 2005

UniProt:O53161
type: ProteinReference
xref: UnificationXref2211
organism: BioSource1

UniProt:P63650
type: ProteinReference
xref: UnificationXref1026
organism: BioSource1

UnificationXref1606
type: UnificationXref
id: CHEBI:16978
db: ChEBI

UnificationXref1607
type: UnificationXref
id: 266066
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266066

UnificationXref1604
type: UnificationXref
id: 4236119
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236119

UnificationXref1605
type: UnificationXref
id: REACT_153503
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153503.3

UnificationXref1602
type: UnificationXref
id: 4234175
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234175

UniProt:P63648
type: ProteinReference
xref: UnificationXref1024
organism: BioSource1

UnificationXref1603
type: UnificationXref
id: REACT_112323
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112323.8

UnificationXref1600
type: UnificationXref
id: 4234172
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234172

UnificationXref1601
type: UnificationXref
id: 4234173
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234173

UniProt:O53174
type: ProteinReference
xref: UnificationXref2511
organism: BioSource1

UnificationXref1609
type: UnificationXref
id: 266013
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266013

UnificationXref1608
type: UnificationXref
id: REACT_15706
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15706.2

UnificationXref1615
type: UnificationXref
id: 4236224
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236224

UnificationXref1616
type: UnificationXref
id: REACT_153813
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153813.3

UnificationXref1617
type: UnificationXref
id: CHEBI:34450
db: ChEBI

UnificationXref1618
type: UnificationXref
id: 2142739
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142739

UnificationXref1611
type: UnificationXref
id: O06138
db: UniProt

UnificationXref1612
type: UnificationXref
id: 4234848
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234848

UnificationXref1613
type: UnificationXref
id: 4234850
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234850

UnificationXref1614
type: UnificationXref
id: REACT_140716
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140716.5

UnificationXref1610
type: UnificationXref
id: REACT_17252
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17252.2

MTCY09F9.32c
type: ProteinReference
name: tpx
name: MT1982
name: UniProt:P66952 tpx
name: Rv1932
xref: UnificationXref4687
comment: SIMILARITY Belongs to the AhpC/TSA family. Tpx subfamily.SIMILARITY Contains 1 thioredoxin domain.
organism: BioSource1

UnificationXref1619
type: UnificationXref
id: REACT_150802
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150802.1

http://identifiers.org/pubmed/16104727
type: PublicationXref
id: 16104727
author: Zhai, H
author: Baumgart, S
author: McLafferty, FW
author: Burns, KE
author: Dorrestein, PC
author: Begley, TP
db: Pubmed
title: Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis
source: J Am Chem Soc 127:11602-3
year: 2005

UnificationXref1624
type: UnificationXref
id: 2142835
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142835

RelationshipXref407
type: RelationshipXref
id: 4233826
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233826

UnificationXref1625
type: UnificationXref
id: REACT_151653
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151653.1

RelationshipXref406
type: RelationshipXref
id: GO:0004838
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1622
type: UnificationXref
id: REACT_152366
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152366.1

RelationshipXref405
type: RelationshipXref
id: GO:0006554
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1623
type: UnificationXref
id: CHEBI:34130
db: ChEBI

RelationshipXref404
type: RelationshipXref
id: 4233819
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233819

UnificationXref1628
type: UnificationXref
id: REACT_150932
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150932.1

2'-deoxyinosine
type: SmallMoleculeReference
name: deoxyinosine
name: 2'-deoxyinosine [ChEBI:28997]
xref: UnificationXref1977

UnificationXref1629
type: UnificationXref
id: 2161818
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161818

UnificationXref1626
type: UnificationXref
id: CHEBI:34157
db: ChEBI

RelationshipXref409
type: RelationshipXref
id: GO:0003842
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1627
type: UnificationXref
id: 2142792
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142792

RelationshipXref408
type: RelationshipXref
id: GO:0006559
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1620
type: UnificationXref
id: CHEBI:34490
db: ChEBI

RelationshipXref403
type: RelationshipXref
id: GO:0004361
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1621
type: UnificationXref
id: 2142662
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142662

RelationshipXref402
type: RelationshipXref
id: 4233789
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233789

RelationshipXref401
type: RelationshipXref
id: GO:0004043
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref400
type: RelationshipXref
id: GO:0009083
db: GENE ONTOLOGY
relationship type: MI:0359

UniProt:P63642
type: ProteinReference
xref: UnificationXref2856
organism: BioSource1

UniProt:P66940
type: ProteinReference
xref: UnificationXref207
organism: BioSource1

http://identifiers.org/pubmed/7706277
type: PublicationXref
id: 7706277
author: Lou, L
author: Nakamura, J
db: Pubmed
title: Biochemical characterization of human GMP synthetase
source: J Biol Chem 270:7347-7353
year: 1995

UnificationXref1633
type: UnificationXref
id: REACT_151976
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151976.1

UnificationXref1634
type: UnificationXref
id: CHEBI:63970
db: ChEBI

UnificationXref1635
type: UnificationXref
id: 2142765
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142765

UnificationXref1636
type: UnificationXref
id: REACT_150593
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150593.1

UnificationXref1637
type: UnificationXref
id: CHEBI:63969
db: ChEBI

UnificationXref1638
type: UnificationXref
id: 2142779
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142779

UnificationXref1639
type: UnificationXref
id: REACT_151638
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151638.1

MPS IV - Morquio syndrome B
type: Pathway
data source: Provenance1
pathway component: REACT 134911.5
evidence: Evidence510
xref: UnificationXref3535
xref: UnificationXref3534
pathway order: PathwayStep84
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/13575436
type: PublicationXref
id: 13575436
author: Robbins, PW
author: Lipmann, F
db: Pubmed
title: Separation of the two enzymatic phases in active sulfate synthesis
source: J Biol Chem 233:681-5
year: 1958

UnificationXref1630
type: UnificationXref
id: REACT_150812
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150812.1

UnificationXref1631
type: UnificationXref
id: CHEBI:63974
db: ChEBI

UnificationXref1632
type: UnificationXref
id: 2142682
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142682

RelationshipXref422
type: RelationshipXref
id: GO:0017061
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref423
type: RelationshipXref
id: 4235426
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235426

RelationshipXref424
type: RelationshipXref
id: GO:0019509
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref425
type: RelationshipXref
id: GO:0006595
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref420
type: RelationshipXref
id: GO:0000050
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref421
type: RelationshipXref
id: GO:0045329
db: GENE ONTOLOGY
relationship type: MI:0359

Taurochenodeoxycholate [ChEBI:9407]
type: SmallMoleculeReference
name: Taurochenodeoxycholate
xref: UnificationXref567

RelationshipXref426
type: RelationshipXref
id: GO:0008172
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref427
type: RelationshipXref
id: 4234796
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234796

RelationshipXref428
type: RelationshipXref
id: GO:0046219
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref429
type: RelationshipXref
id: GO:0003884
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/10958673
type: PublicationXref
id: 10958673
author: Yoshida, H
author: Haze, K
author: Yura, T
author: Yanagi, H
author: Mori, K
author: Okada, T
author: Negishi, M
db: Pubmed
title: ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
source: Mol Cell Biol 20:6755-67
year: 2000

RelationshipXref413
type: RelationshipXref
id: 4233662
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233662

RelationshipXref414
type: RelationshipXref
id: GO:0004585
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref411
type: RelationshipXref
id: GO:0006562
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref412
type: RelationshipXref
id: GO:0004087
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref410
type: RelationshipXref
id: 4233707
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233707

http://identifiers.org/pubmed/19935646
type: PublicationXref
id: 19935646
author: Jang, HG
author: Dang, L
author: Keenan, MC
author: Vander Heiden, MG
author: Bennett, BD
author: Rabinowitz, JD
author: Driggers, EM
author: Gross, S
author: Ward, PS
author: Fantin, VR
author: Thompson, CB
author: Cantley, LC
author: Marks, KM
author: White, DW
author: Bittinger, MA
author: Prins, RM
author: Su, SM
author: Yen, KE
author: Liau, LM
author: Jin, S
db: Pubmed
title: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
source: Nature 462:739-44
year: 2009

MTCY159.16
type: ProteinReference
name: MT2615
name: Rv2540c
name: aroF
name: aroC
name: UniProt:P63611 aroC
xref: UnificationXref5370
comment: CATALYTIC ACTIVITY 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.PATHWAY Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.MISCELLANEOUS Was identified as a high-confidence drug target.SIMILARITY Belongs to the chorismate synthase family.
organism: BioSource1

RelationshipXref419
type: RelationshipXref
id: 4233676
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233676

RelationshipXref417
type: RelationshipXref
id: 4233682
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233682

RelationshipXref418
type: RelationshipXref
id: GO:0004056
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref415
type: RelationshipXref
id: 4233670
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233670

RelationshipXref416
type: RelationshipXref
id: GO:0004055
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref440
type: RelationshipXref
id: GO:0004123
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref441
type: RelationshipXref
id: 4235578
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235578

RelationshipXref442
type: RelationshipXref
id: GO:0019346
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref443
type: RelationshipXref
id: GO:0004180
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref444
type: RelationshipXref
id: 4235432
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235432

RelationshipXref445
type: RelationshipXref
id: GO:0047982
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref446
type: RelationshipXref
id: 4235589
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235589

RelationshipXref447
type: RelationshipXref
id: GO:0080146
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref448
type: RelationshipXref
id: 4235580
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235580

RelationshipXref449
type: RelationshipXref
id: GO:0016846
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref431
type: RelationshipXref
id: GO:0008891
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref432
type: RelationshipXref
id: 4235017
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235017

RelationshipXref430
type: RelationshipXref
id: 4235006
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235006

RelationshipXref435
type: RelationshipXref
id: GO:0046487
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/19935667
type: PublicationXref
id: 19935667
author: Hall, RA
author: Ritter, SL
db: Pubmed
title: Fine-tuning of GPCR activity by receptor-interacting proteins
source: Nat Rev Mol Cell Biol 10:819-30
year: 2009

RelationshipXref436
type: RelationshipXref
id: GO:0004478
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref433
type: RelationshipXref
id: GO:0047969
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref434
type: RelationshipXref
id: 4235019
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235019

Utilization of Ketone Bodies
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction88
pathway component: BiochemicalReaction89
evidence: Evidence160
xref: RelationshipXref136
xref: UnificationXref1035
xref: UnificationXref1034
pathway order: PathwayStep157
pathway order: PathwayStep156
display name: Ketone body catabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref439
type: RelationshipXref
id: 4235570
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235570

RelationshipXref437
type: RelationshipXref
id: 4234503
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234503

RelationshipXref438
type: RelationshipXref
id: GO:0004122
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/11988738
type: PublicationXref
id: 11988738
author: Lukas, J
author: Jackson, PK
author: Reimann, JD
author: Sorensen, CS
author: Hsu, JY
db: Pubmed
title: E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
source: Nat Cell Biol 4:358-66
year: 2002

http://identifiers.org/pubmed/12626323
type: PublicationXref
id: 12626323
author: Jiang, G
author: Zhang, BB
db: Pubmed
title: Glucagon and regulation of glucose metabolism
source: Am J Physiol Endocrinol Metab 284:E671-8
year: 2003

http://identifiers.org/pubmed/19172412
type: PublicationXref
id: 19172412
author: Wu, Y
author: Jakobs, C
author: Gibson, KM
author: Pearl, PL
author: Pettiford, JM
author: Knerr, I
author: Theodore, WH
author: Forester, K
author: Carter Snead O, 3rd
author: Cortez, MA
db: Pubmed
title: Succinic semialdehyde dehydrogenase deficiency: lessons from mice and men
source: J Inherit Metab Dis 32:343-52
year: 2009

Purine salvage
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction174
pathway component: BiochemicalReaction168
pathway component: BiochemicalReaction169
pathway component: BiochemicalReaction173
pathway component: BiochemicalReaction171
pathway component: BiochemicalReaction172
pathway component: BiochemicalReaction170
evidence: Evidence302
xref: UnificationXref2064
xref: RelationshipXref286
xref: UnificationXref2063
pathway order: PathwayStep298
pathway order: PathwayStep293
pathway order: PathwayStep296
pathway order: PathwayStep295
pathway order: PathwayStep297
pathway order: PathwayStep299
pathway order: PathwayStep294
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref467
type: RelationshipXref
id: GO:0008495
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/10521434
type: PublicationXref
id: 10521434
author: Gould, SJ
author: Geisbrecht, BV
db: Pubmed
title: The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase
source: J Biol Chem 274:30527-33
year: 1999

RelationshipXref466
type: RelationshipXref
id: 4234550
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234550

RelationshipXref469
type: RelationshipXref
id: GO:0006783
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref468
type: RelationshipXref
id: 4236032
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236032

RelationshipXref463
type: RelationshipXref
id: GO:0004729
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref462
type: RelationshipXref
id: 4234538
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234538

RelationshipXref465
type: RelationshipXref
id: GO:0004325
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref464
type: RelationshipXref
id: 4234532
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234532

RelationshipXref460
type: RelationshipXref
id: 4234526
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234526

RelationshipXref461
type: RelationshipXref
id: GO:0004853
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref459
type: RelationshipXref
id: GO:0004418
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref458
type: RelationshipXref
id: 4234544
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234544

RelationshipXref457
type: RelationshipXref
id: GO:0004655
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref456
type: RelationshipXref
id: GO:0034641
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref455
type: RelationshipXref
id: GO:0000096
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref454
type: RelationshipXref
id: GO:0000098
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref453
type: RelationshipXref
id: GO:0070221
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref452
type: RelationshipXref
id: 4235595
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235595

RelationshipXref451
type: RelationshipXref
id: GO:0070224
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/19006241
type: PublicationXref
id: 19006241
author: Häberle, J
author: Höhne, W
author: Engel, K
db: Pubmed
title: Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene
source: Hum Mutat 30:300-7
year: 2009

Reversal of Alkylation Damage By DNA Dioxygenases
type: Pathway
data source: Provenance1
pathway component: REACT 80455.9
pathway component: REACT 77089.9
evidence: Evidence640
xref: UnificationXref4296
xref: RelationshipXref583
xref: UnificationXref4297
pathway order: PathwayStep622
pathway order: PathwayStep626
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref450
type: RelationshipXref
id: 4235575
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235575

(S)-3-Hydroxytetradecanoyl-CoA
type: SmallMoleculeReference
name: (S)-3-Hydroxytetradecanoyl-CoA [ChEBI:27466]
xref: UnificationXref816

RelationshipXref485
type: RelationshipXref
id: GO:0003979
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref484
type: RelationshipXref
id: GO:0006805
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref487
type: RelationshipXref
id: GO:0006065
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref486
type: RelationshipXref
id: 4234490
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234490

RelationshipXref489
type: RelationshipXref
id: GO:0050427
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref488
type: RelationshipXref
id: GO:0052695
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref480
type: RelationshipXref
id: GO:0003987
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref481
type: RelationshipXref
id: 4235139
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235139

RelationshipXref482
type: RelationshipXref
id: 4233874
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233874

RelationshipXref483
type: RelationshipXref
id: GO:0006069
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/15155722
type: PublicationXref
id: 15155722
author: Spagnolo, L
author: D'Orazio, M
author: Törö, I
author: Rotilio, G
author: Pedersen, JZ
author: Carugo, O
author: O'Neill, P
author: Djinovic-Carugo, K
author: Battistoni, A
db: Pubmed
title: Unique features of the sodC-encoded superoxide dismutase from Mycobacterium tuberculosis, a fully functional copper-containing enzyme lacking zinc in the active site
source: J Biol Chem 279:33447-55
year: 2004

ChEBI:27458 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
type: SmallMoleculeReference
name: 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
xref: UnificationXref1397

RelationshipXref476
type: RelationshipXref
id: 4234818
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234818

S-(glycyl)-L-cysteine (Gly)
type: SequenceModificationVocabulary
xref: UnificationXref5270

RelationshipXref475
type: RelationshipXref
id: 4234827
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234827

RelationshipXref474
type: RelationshipXref
id: 4234837
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234837

RelationshipXref473
type: RelationshipXref
id: GO:0008401
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/11242102
type: PublicationXref
id: 11242102
author: Khanna, KK
db: Pubmed
title: DNA double-strand breaks: signaling, repair and the cancer connection.
source: Nat Genet 27:247-54
year: 2001

RelationshipXref479
type: RelationshipXref
id: 4234439
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234439

RelationshipXref478
type: RelationshipXref
id: 4234444
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234444

RelationshipXref477
type: RelationshipXref
id: GO:0008131
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref471
type: RelationshipXref
id: GO:0016125
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref472
type: RelationshipXref
id: GO:0006690
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref470
type: RelationshipXref
id: GO:0006778
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/16909208
type: PublicationXref
id: 16909208
author: Kagan, HM
author: Lucero, HA
db: Pubmed
title: Lysyl oxidase: an oxidative enzyme and effector of cell function
source: Cell Mol Life Sci 63:2304-16
year: 2006

UnificationXref309
type: UnificationXref
id: 372364
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=372364

UnificationXref308
type: UnificationXref
id: REACT_3998
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3998.1

UnificationXref305
type: UnificationXref
id: 113573
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113573

UnificationXref304
type: UnificationXref
id: REACT_103234
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103234.9

UnificationXref307
type: UnificationXref
id: 113525
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113525

UnificationXref306
type: UnificationXref
id: REACT_4430
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4430.1

UnificationXref301
type: UnificationXref
id: P65686
db: UniProt

RelationshipXref371
type: RelationshipXref
id: GO:0006767
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref300
type: UnificationXref
id: REACT_4014
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4014.1

RelationshipXref370
type: RelationshipXref
id: GO:0032324
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref303
type: UnificationXref
id: 4233564
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233564

RelationshipXref373
type: RelationshipXref
id: GO:0004587
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref302
type: UnificationXref
id: 4233562
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233562

RelationshipXref372
type: RelationshipXref
id: GO:0006766
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref374
type: RelationshipXref
id: 4233700
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233700

RelationshipXref375
type: RelationshipXref
id: GO:0017084
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref376
type: RelationshipXref
id: 4235184
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235184

UnificationXref310
type: UnificationXref
id: REACT_14919
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14919.2

RelationshipXref377
type: RelationshipXref
id: GO:0004066
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref378
type: RelationshipXref
id: 4233688
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233688

RelationshipXref379
type: RelationshipXref
id: GO:0004617
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/2960695
type: PublicationXref
id: 2960695
author: Danon, MJ
author: Harker, D
author: Spear, D
author: DiMauro, S
author: Vora, S
db: Pubmed
title: Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII.
source: J Clin Invest 80:1479-85
year: 1987

http://identifiers.org/pubmed/7284378
type: PublicationXref
id: 7284378
author: Desgranges, C
author: Rabaud, M
author: Razaka, G
author: Bricaud, H
db: Pubmed
title: Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase
source: Biochim Biophys Acta 654:211-8
year: 1981

http://identifiers.org/pubmed/1689758
type: PublicationXref
id: 1689758
author: Dahlbäck, K
author: Ljungquist, A
author: Löfberg, H
author: Engvall, E
author: Sakai, LY
author: Dahlbäck, B
db: Pubmed
title: Fibrillin immunoreactive fibers constitute a unique network in the human dermis: immunohistochemical comparison of the distributions of fibrillin, vitronectin, amyloid P component, and orcein stainable structures in normal skin and elastosis
source: J Invest Dermatol 94:284-91
year: 1990

http://identifiers.org/pubmed/9564029
type: PublicationXref
id: 9564029
author: Kushner, JP
author: Phillips, JD
author: Hill, CP
author: Whitby, FG
db: Pubmed
title: Crystal structure of human uroporphyrinogen decarboxylase
source: EMBO J 17:2463-71
year: 1998

UniProt:P65487
type: ProteinReference
xref: UnificationXref987
organism: BioSource1

RelationshipXref380
type: RelationshipXref
id: 4235400
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235400

http://identifiers.org/pubmed/4218100
type: PublicationXref
id: 4218100
author: Matalon, R
author: Brandt, IK
author: Dorfman, A
author: Justice, P
author: Arbogast, B
db: Pubmed
title: Morquio's syndrome: deficiency of a chondroitin sulfate N-acetylhexosamine sulfate sulfatase
source: Biochem Biophys Res Commun 61:759-65
year: 1974

RelationshipXref384
type: RelationshipXref
id: GO:0008652
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref383
type: RelationshipXref
id: GO:0006564
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref382
type: RelationshipXref
id: 4235394
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235394

RelationshipXref381
type: RelationshipXref
id: GO:0004647
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref387
type: RelationshipXref
id: GO:0008470
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref388
type: RelationshipXref
id: 4233728
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233728

RelationshipXref385
type: RelationshipXref
id: GO:0003826
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref386
type: RelationshipXref
id: 4233722
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233722

Cholesterol biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction104
pathway component: BiochemicalReaction103
pathway component: BiochemicalReaction102
evidence: Evidence190
xref: RelationshipXref171
xref: UnificationXref1280
xref: UnificationXref1279
pathway order: PathwayStep186
pathway order: PathwayStep187
pathway order: PathwayStep185
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref389
type: RelationshipXref
id: GO:0004485
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref393
type: RelationshipXref
id: 4233767
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233767

RelationshipXref392
type: RelationshipXref
id: 4233755
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233755

RelationshipXref395
type: RelationshipXref
id: 4233772
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233772

RelationshipXref394
type: RelationshipXref
id: GO:0003860
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref391
type: RelationshipXref
id: 4233749
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233749

RelationshipXref390
type: RelationshipXref
id: 4233743
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233743

RelationshipXref396
type: RelationshipXref
id: GO:0008442
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref397
type: RelationshipXref
id: 4233778
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233778

RelationshipXref398
type: RelationshipXref
id: GO:0004491
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref399
type: RelationshipXref
id: 4233783
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233783

http://identifiers.org/pubmed/18403674
type: PublicationXref
id: 18403674
author: Steele, C
author: Mossman, BT
author: Dostert, C
author: Tschopp, J
author: Van Bruggen, R
author: Pétrilli, V
db: Pubmed
title: Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
source: Science 320:674-7
year: 2008

http://identifiers.org/pubmed/10529898
type: PublicationXref
id: 10529898
author: Wahli, W
author: Desvergne, B
db: Pubmed
title: Peroxisome proliferator-activated receptors: nuclear control of metabolism
source: Endocr Rev 20:649-88
year: 1999

(R)-2-hydroxyglutaric acid
type: SmallMoleculeReference
name: (R)-2-Hydroxyglutarate
name: ChEBI:32796 (R)-2-hydroxyglutaric acid
xref: UnificationXref1805

http://identifiers.org/pubmed/3208766
type: PublicationXref
id: 3208766
author: Day, IN
author: Fothergill, JE
author: McAleese, SM
author: Hinks, LJ
author: Dunbar, B
db: Pubmed
title: Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE)
source: Eur J Biochem 178:413-7
year: 1988

http://identifiers.org/pubmed/11879535
type: PublicationXref
id: 11879535
author: Eyre, D
db: Pubmed
title: Collagen of articular cartilage
source: Arthritis Res 4:30-5
year: 2002

UnificationXref348
type: UnificationXref
id: 4233861
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233861

UnificationXref349
type: UnificationXref
id: 4235157
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235157

UnificationXref344
type: UnificationXref
id: REACT_138536
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138536.5

UnificationXref345
type: UnificationXref
id: 4235163
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235163

UnificationXref346
type: UnificationXref
id: REACT_135171
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135171.5

UnificationXref347
type: UnificationXref
id: 4233860
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233860

UnificationXref352
type: UnificationXref
id: 4235161
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235161

UnificationXref351
type: UnificationXref
id: 4235160
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235160

UnificationXref354
type: UnificationXref
id: 4233604
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233604

UnificationXref353
type: UnificationXref
id: 4235158
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235158

UnificationXref350
type: UnificationXref
id: 4235159
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235159

UnificationXref339
type: UnificationXref
id: MOD:00128
db: MOD

UnificationXref337
type: UnificationXref
id: REACT_108178
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108178.9

UnificationXref338
type: UnificationXref
id: Q10639
db: UniProt

UnificationXref335
type: UnificationXref
id: REACT_104040
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104040.9

UnificationXref336
type: UnificationXref
id: 4236061
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236061

UnificationXref333
type: UnificationXref
id: 4233573
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233573

UnificationXref334
type: UnificationXref
id: 4233575
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233575

http://identifiers.org/pubmed/10925197
type: PublicationXref
id: 10925197
author: Lehmann, AR
db: Pubmed
title: Replication of UV-damaged DNA: new insights into links between DNA polymerases, mutagenesis and human disease.
source: Gene 253:1-12
year: 2000

UnificationXref343
type: UnificationXref
id: 4235164
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235164

UnificationXref342
type: UnificationXref
id: 4235162
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235162

UnificationXref341
type: UnificationXref
id: 4235153
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235153

UnificationXref340
type: UnificationXref
id: 4235152
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235152

UnificationXref322
type: UnificationXref
id: 4236057
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236057

UnificationXref323
type: UnificationXref
id: REACT_92237
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92237.9

UnificationXref324
type: UnificationXref
id: CHEBI:16077
db: ChEBI

UnificationXref325
type: UnificationXref
id: 29548
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29548

UnificationXref326
type: UnificationXref
id: REACT_5634
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5634.2

UnificationXref327
type: UnificationXref
id: P95090
db: UniProt

UnificationXref328
type: UnificationXref
id: 4233567
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233567

UnificationXref329
type: UnificationXref
id: 4233568
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233568

UniProt:P65412
type: ProteinReference
xref: UnificationXref4125
organism: BioSource1

DNA Repair
type: Pathway
data source: Provenance1
pathway component: REACT 103570.9
pathway component: REACT 88946.9
pathway component: REACT 98432.9
pathway component: Base Excision Repair
pathway component: REACT 29470.10
evidence: Evidence655
xref: UnificationXref4333
xref: RelationshipXref587
xref: UnificationXref4334
pathway order: PathwayStep607
pathway order: PathwayStep628
pathway order: PathwayStep641
pathway order: PathwayStep634
pathway order: PathwayStep617
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10958654
type: PublicationXref
id: 10958654
author: Vincent, MF
author: Marie, S
author: Van den Berghe, G
author: Race, V
db: Pubmed
title: Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency
source: Hum Mol Genet 9:2159-2165
year: 2000

UnificationXref330
type: UnificationXref
id: O53360
db: UniProt

UnificationXref332
type: UnificationXref
id: 4233572
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233572

UnificationXref331
type: UnificationXref
id: 4233571
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233571

UnificationXref313
type: UnificationXref
id: REACT_89417
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89417.9

UnificationXref314
type: UnificationXref
id: 4233647
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233647

UnificationXref311
type: UnificationXref
id: 4234865
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234865

UnificationXref312
type: UnificationXref
id: 4234867
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234867

UnificationXref317
type: UnificationXref
id: REACT_159286
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159286.3

UnificationXref318
type: UnificationXref
id: 4233635
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233635

UnificationXref315
type: UnificationXref
id: REACT_88320
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88320.9

UnificationXref316
type: UnificationXref
id: 4233641
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233641

UnificationXref319
type: UnificationXref
id: REACT_85223
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85223.9

http://identifiers.org/pubmed/19946895
type: PublicationXref
id: 19946895
author: Albers, E
db: Pubmed
title: Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine
source: IUBMB Life 61:1132-42
year: 2009

UnificationXref321
type: UnificationXref
id: REACT_30934
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30934.10

UnificationXref320
type: UnificationXref
id: 4233634
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233634

UnificationXref397
type: UnificationXref
id: P0A586
db: UniProt

UnificationXref398
type: UnificationXref
id: 4233597
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233597

UnificationXref395
type: UnificationXref
id: P0A584
db: UniProt

UnificationXref396
type: UnificationXref
id: 4233594
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233594

Stoichiometry513
type: Stoichiometry
physical entity: Complex250
stoichiometric coefficient: 6.0

UnificationXref1533
type: UnificationXref
id: 4236227
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236227

UnificationXref393
type: UnificationXref
id: 29364
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29364

Stoichiometry512
type: Stoichiometry
physical entity: SmallMolecule801
stoichiometric coefficient: 1.0

UnificationXref1532
type: UnificationXref
id: REACT_129440
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129440.5

UnificationXref394
type: UnificationXref
id: REACT_2991
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2991.3

Stoichiometry511
type: Stoichiometry
physical entity: SmallMolecule802
stoichiometric coefficient: 1.0

UnificationXref1531
type: UnificationXref
id: 4234864
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234864

UnificationXref391
type: UnificationXref
id: REACT_4982
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4982.1

Stoichiometry510
type: Stoichiometry
physical entity: Protein714
stoichiometric coefficient: 1.0

UnificationXref1530
type: UnificationXref
id: 4234862
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234862

UnificationXref392
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Stoichiometry517
type: Stoichiometry
physical entity: SmallMolecule441
stoichiometric coefficient: 1.0

Evidence723
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/22653731
xref: http://identifiers.org/pubmed/22983114
xref: http://identifiers.org/pubmed/23260141
xref: http://identifiers.org/pubmed/21768372
xref: http://identifiers.org/pubmed/19837038
xref: http://identifiers.org/pubmed/22796206
xref: http://identifiers.org/pubmed/17108000
xref: http://identifiers.org/pubmed/21725318
xref: http://identifiers.org/pubmed/23256519
xref: http://identifiers.org/pubmed/22952392
xref: http://identifiers.org/pubmed/21554866
xref: http://identifiers.org/pubmed/16678095
xref: http://identifiers.org/pubmed/16678096
xref: http://identifiers.org/pubmed/17141155
comment: 19 WNT proteins have been identified in human cells. The WNTs are members of a conserved metazoan family of secreted morphogens that activate several signaling pathways in the responding cell: the canonical (beta-catenin) WNT signaling cascade and several non-canonical pathways, including the planar cell polarity (PCP), the regulation of intracellular calcium signaling and activation of JNK kinases. WNT proteins exist in a gradient outside the secreting cell and are able to act over both short and long ranges to promote proliferation, changes in cell migration and polarity and tissue homeostasis, among others (reviewed in Saito-Diaz et al, 2012; Willert and Nusse, 2012). The WNTs are ~40kDa proteins with 23 conserved cysteine residues in the N-terminal that may form intramolecular disulphide bonds. They also contain an N-terminal signal sequence and a number of N-linked glycosylation sites (Janda et al, 2012). In addition to being glycosylated, WNTs are also lipid-modified in the endoplasmic reticulum by a WNT-specific O-acyl-transferase, Porcupine (PORCN), contributing to their characteristic hydrophobicity. PORCN-dependent palmitoylation is required for the secretion of WNT as well as its signaling activity, as either depletion of PORCN or mutation of the conserved serine acylation site results in the intracellular accumulation of WNT ligand (Takada et al, 2006; Barrott et al, 2011; Biechele et al, 2011; reviewed in Willert and Nusse, 2012). Secretion of WNT requires a number of other dedicated factors including the sorting receptor Wntless (WLS) (also knownas Evi, Sprinter, and GPR177), which binds WNT and escorts it to the cell surface (Bänziger et al, 2006; Bartscherer et al, 2006; Goodman et al, 2006). A WNT-specific retromer containing SNX3 is subsequently required for the recycling of WLS back to the Golgi (reviewed in Herr et al, 2012; Johannes and Wunder, 2011). Once at the cell surface, WNT makes extensive contacts with components of the extracellular mat…

UnificationXref1537
type: UnificationXref
id: 1498773
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1498773

Stoichiometry516
type: Stoichiometry
physical entity: Protein715
stoichiometric coefficient: 1.0

Evidence724
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19204114
xref: http://identifiers.org/pubmed/20576942
xref: http://identifiers.org/pubmed/12967557
xref: http://identifiers.org/pubmed/10858654
xref: http://identifiers.org/pubmed/16099039
xref: http://identifiers.org/pubmed/18710302
xref: http://identifiers.org/pubmed/19365405
xref: http://identifiers.org/pubmed/17143292
xref: http://identifiers.org/pubmed/23256519
xref: http://identifiers.org/pubmed/22952392
xref: http://identifiers.org/pubmed/17230199
xref: http://identifiers.org/pubmed/19530173
xref: http://identifiers.org/pubmed/19619488
comment: WNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Saito-Diaz et al, 2013; MacDonald et al, 2009). The pathway is named for the WNT ligands, a large family of secreted cysteine-rich glycoproteins. At least 19 WNT members have been identified in humans and mice with distinct expression patterns during development (reviewed in Willert and Nusse, 2012). These ligands can activate at least three different downstream signaling cascades depending on which receptors they engage. In the so-called 'canonical' WNT signaling pathway, WNT ligands bind one of the 10 human Frizzled (FZD) receptors in conjunction with the LRP5/6 co-receptors to activate a transcriptional cascade that controls processes such as cell fate, proliferation and self-renenwal of stem cells. Engagement of the FZD-LRP receptor by WNT ligand results in the stabilization and translocation of cytosolic beta-catenin to the nucleus where it is a co-activator for LEF (lymphoid enhancer-binding factor)- and TCF (T cell factor) -dependent transcription. In the absence of WNT ligand, cytosolic beta-catenin is phosphorylated by a degradation complex consisting of glycogen synthase kinase 3 (GSK3), casein kinase 1 (CK1), Axin and Adenomatous polyposis coli (APC), and subsequently ubiquitinated and degraded by the 26S proteasome (reviewed in Saito-Diaz et al, 2013; Kimmelman and Xu, 2006). In addition to the beta-catenin-dependent transcriptional response, WNT signaling can also activate distinct non-transcriptional pathways that regulate cell migration and polarity. These beta-catenin-independent 'non-canonical' pathways signal through Frizzled receptors independently of LRP5/6, or occur through the tyrosine kinase receptors ROR and RYK (reviewed in Veeman et al, 2003; James et al, 2009). Non-canonical WNT pathways are best studied in Drosophila where the planar cell polarit…

UnificationXref1536
type: UnificationXref
id: CHEBI:60430
db: ChEBI

UnificationXref390
type: UnificationXref
id: 31467
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31467

Stoichiometry515
type: Stoichiometry
physical entity: PhysicalEntity62
stoichiometric coefficient: 1.0

Evidence725
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17496910
xref: http://identifiers.org/pubmed/15450248
xref: http://identifiers.org/pubmed/19458711
xref: http://identifiers.org/pubmed/15520807
xref: http://identifiers.org/pubmed/19648010
xref: http://identifiers.org/pubmed/16939974
xref: http://identifiers.org/pubmed/18043707
xref: http://identifiers.org/pubmed/16260143
xref: http://identifiers.org/pubmed/19762341
xref: http://identifiers.org/pubmed/11742412
xref: http://identifiers.org/pubmed/19935667
xref: http://identifiers.org/pubmed/21781017
xref: http://identifiers.org/pubmed/21252999
xref: http://identifiers.org/pubmed/15863030
xref: http://identifiers.org/pubmed/19619488
xref: http://identifiers.org/pubmed/18483217
xref: http://identifiers.org/pubmed/19379690
xref: http://identifiers.org/pubmed/17084981
xref: http://identifiers.org/pubmed/19536106
xref: http://identifiers.org/pubmed/17604717
comment: Signal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such as hormones and growth factors, or reacting to other types of stimuli, such as light. Stimulation of transmembrane receptors leads to their conformational change which propagates the signal to the intracellular environment by activating downstream signaling cascades. Depending on the cellular context, this may impact cellular proliferation, differentiation, and survival. On the organism level, signal transduction regulates overall growth and behavior. Receptor tyrosine kinases (RTKs) transmit extracellular signals by phosphorylating their protein partners on conserved tyrosine residues. Some of the best studied RTKs are EGFR (reviewed in Avraham and Yarden, 2011), FGFR (reviewed in Eswarakumar et al, 2005), insulin receptor (reviewed in Saltiel and Kahn, 2001), NGF (reviewed in Reichardt, 2006), PDGF (reviewed in Andrae et al, 2008) and VEGF (reviewed in Xie et al, 2004). RTKs frequently activate downstream signaling through RAF/MAP kinases (reviewed in McKay and Morrison, 2007 and Wellbrock et al 2004), AKT (reviewed in Manning and Cantley, 2007) and PLC- gamma (reviewed in Patterson et al), which ultimately results in changes in gene expression and cellular metabolism. Receptor serine/threonine kinases of the TGF-beta family, such as TGF-beta receptors (reviewed in Kang et al. 2009) and BMP receptors (reviewed in Miyazono et al. 2009), transmit extracellular signals by phosphorylating regulatory SMAD proteins on conserved serine and threonine residues. This leads to formation of complexes of regulatory SMADs and SMAD4, which translocate to the nucleus where they act as transcription factors. WNT receptors transmit their signal through beta-catenin. In the absence of ligand, beta-catenin is constitutively degraded in a ubiquitin-dependent manner. WNT receptor stimulation…

UnificationXref1535
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Stoichiometry514
type: Stoichiometry
physical entity: SmallMolecule804
stoichiometric coefficient: 1.0

UnificationXref1534
type: UnificationXref
id: REACT_126441
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126441.5

Evidence720
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/7491953
xref: http://identifiers.org/pubmed/10413847
xref: http://identifiers.org/pubmed/17698287
comment: Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17.Gastrin gene expression is upregulated in both a number of pre-malignant conditions and in established cancer through a variety of mechanisms. Depending on the tissue where it is expressed and the level of expression, differential processing of the polypeptide product leads to the production of different biologically active peptides. In turn, acting through the classical gastrin cholecystokinin B receptor CCK-BR, its isoforms and alternative receptors, these peptides trigger signalling pathways which influence the expression of downstream genes that affect cell survival, angiogenesis and invasion (Wank 1995, de Weerth et al. 1999, Grabowska & Watson 2007)

http://identifiers.org/pubmed/10484781
type: PublicationXref
id: 10484781
author: Petris, MJ
author: Mercer, JF
db: Pubmed
title: The Menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal
source: Hum Mol Genet 8:2107-15
year: 1999

Stoichiometry519
type: Stoichiometry
physical entity: Protein718
stoichiometric coefficient: 1.0

Evidence721
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18043707
xref: http://identifiers.org/pubmed/16902930
xref: http://identifiers.org/pubmed/10202136
comment: G protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors in humans, accounting for more than 1% of the protein-coding capacity of the human genome. All known GPCRs share a common architecture of seven membrane-spanning helices connected by intra- and extracellular loops. The extracellular loops contain two highly-conserved cysteine residues that form disulphide bonds to stabilize the structure of the receptor. They recognize diverse messengers such as light, odorants, small molecules, hormones and neurotransmitters. Most GPCRs act as guanine nucleotide exchange factors; activated by ligand binding, they promote GDP-GTP exchange on associated heterotrimeric guanine nucleotide-binding (G) proteins. There are two models for GPCR-G Protein interactions: 1) ligand-GPCR binding first, then binding to G Proteins; 2) "Pre-coupling" of GPCRs and G Proteins before ligand binding (review Oldham WM and Hamm HE, 2008). These in turn activate effector enzymes or ion channels. GPCRs are involved in a range of physiological roles which include the visual sense, smell, behavioural regulation, functions of the autonomic nervous system and regulation of the immune system and inflammation. GPCRs are divided into 6 classes based on sequence homology and functional similarity; the main mammalian families are classes A/1-C/3; Class A/1 (Rhodopsin-like) Class B/2 (Secretin receptor family) Class C/3 (Metabotropic glutamate/pheromones) Class D/4 (fungal mating pheromone receptors) Class E/5 (cAMP receptors) Class F/6 (Frizzled/Smoothened) Here, those Class A/1 (Rhodopsin-like) receptors that bind peptide ligands have been annotated. The binding events mediated by other classes of receptors, as well as the downstream events triggered by receptor-ligand interactions will be annotated in future releases of Reactome.

UnificationXref1539
type: UnificationXref
id: 1524038
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524038

Stoichiometry518
type: Stoichiometry
physical entity: Protein717
stoichiometric coefficient: 2.0

Evidence722
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8167409
xref: http://identifiers.org/pubmed/12717451
xref: http://identifiers.org/pubmed/17117926
xref: http://identifiers.org/pubmed/22108505
xref: http://identifiers.org/pubmed/17397399
comment: All WNT ligands are predicted to be highly glycosylated. By similarity with WNT ligands in mouse, human WNTs are believed to undergo N-linked glycosylation at multiple asparagine residues and this glycosylation is critical for their secretion (Smolich et al, 1993; Willert et al, 2003, Komekado et al, 2006; Kurayoshi et al, 2007). The mechanism of N-linked glycosylation is not shown here. For a more detailed description, please refer to pathway "Asparagine N-linked glycosylation".

UnificationXref1538
type: UnificationXref
id: REACT_124003
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124003.1

UnificationXref389
type: UnificationXref
id: CHEBI:16938
db: ChEBI

UnificationXref388
type: UnificationXref
id: REACT_4609
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4609.3

UnificationXref384
type: UnificationXref
id: 4236062
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236062

UnificationXref385
type: UnificationXref
id: REACT_86003
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86003.9

UnificationXref386
type: UnificationXref
id: CHEBI:18009
db: ChEBI

UnificationXref387
type: UnificationXref
id: 29366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29366

periplasmic space
type: CellularLocationVocabulary
xref: UnificationXref4735

Stoichiometry500
type: Stoichiometry
physical entity: Protein710
stoichiometric coefficient: 1.0

UnificationXref1520
type: UnificationXref
id: 264638
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=264638

UnificationXref380
type: UnificationXref
id: 4233588
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233588

UnificationXref381
type: UnificationXref
id: 4233589
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233589

Stoichiometry502
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 2.0

UnificationXref1522
type: UnificationXref
id: CHEBI:30089
db: ChEBI

UnificationXref382
type: UnificationXref
id: 4233591
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233591

Stoichiometry501
type: Stoichiometry
physical entity: Complex247
stoichiometric coefficient: 2.0

UnificationXref1521
type: UnificationXref
id: REACT_15210
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15210.2

UnificationXref383
type: UnificationXref
id: REACT_158614
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158614.3

Stoichiometry504
type: Stoichiometry
physical entity: Protein713
stoichiometric coefficient: 1.0

UnificationXref1524
type: UnificationXref
id: REACT_116629
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116629.1

Stoichiometry503
type: Stoichiometry
physical entity: PhysicalEntity62
stoichiometric coefficient: 1.0

UnificationXref1523
type: UnificationXref
id: 1524044
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524044

Stoichiometry506
type: Stoichiometry
physical entity: SmallMolecule801
stoichiometric coefficient: 2.0

UnificationXref1526
type: UnificationXref
id: 4234858
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234858

Stoichiometry505
type: Stoichiometry
physical entity: Protein714
stoichiometric coefficient: 1.0

UnificationXref1525
type: UnificationXref
id: 4234857
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234857

Stoichiometry508
type: Stoichiometry
physical entity: proton
stoichiometric coefficient: 6.0

UnificationXref1528
type: UnificationXref
id: 4234860
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234860

Stoichiometry507
type: Stoichiometry
physical entity: Complex249
stoichiometric coefficient: 6.0

UnificationXref1527
type: UnificationXref
id: 4234859
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234859

Stoichiometry509
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 3.0

UnificationXref1529
type: UnificationXref
id: 4234861
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234861

Inositol phosphate metabolism
type: Pathway
data source: Provenance1
pathway component: Synthesis of IP2, IP, and Ins in the cytosol
evidence: Evidence92
xref: RelationshipXref79
xref: UnificationXref534
xref: UnificationXref535
pathway order: PathwayStep89
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref378
type: UnificationXref
id: REACT_101214
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101214.9

UnificationXref377
type: UnificationXref
id: 4233585
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233585

UnificationXref379
type: UnificationXref
id: Q7D9P4
db: UniProt

Stoichiometry535
type: Stoichiometry
physical entity: Protein730
stoichiometric coefficient: 1.0

UnificationXref1555
type: UnificationXref
id: GO:0005788
db: GENE ONTOLOGY

UnificationXref371
type: UnificationXref
id: 29410
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29410

Stoichiometry534
type: Stoichiometry
physical entity: Mg++
stoichiometric coefficient: 1.0

UnificationXref1554
type: UnificationXref
id: REACT_119727
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119727.1

UnificationXref372
type: UnificationXref
id: REACT_3006
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3006.3

Stoichiometry533
type: Stoichiometry
physical entity: Protein729
stoichiometric coefficient: 2.0

UnificationXref1553
type: UnificationXref
id: 211579
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211579

Stoichiometry532
type: Stoichiometry
physical entity: Protein728
stoichiometric coefficient: 12.0

UnificationXref1552
type: UnificationXref
id: REACT_128980
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128980.5

UnificationXref370
type: UnificationXref
id: CHEBI:18066
db: ChEBI

Stoichiometry531
type: Stoichiometry
physical entity: Complex260
stoichiometric coefficient: 5.0

UnificationXref1551
type: UnificationXref
id: 4236115
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236115

UnificationXref375
type: UnificationXref
id: Q79FY3
db: UniProt

Stoichiometry530
type: Stoichiometry
physical entity: SmallMolecule448
stoichiometric coefficient: 1.0

UnificationXref1550
type: UnificationXref
id: REACT_146549
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146549.5

UnificationXref376
type: UnificationXref
id: 4233583
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233583

UnificationXref373
type: UnificationXref
id: 29452
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29452

UnificationXref374
type: UnificationXref
id: REACT_5012
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5012.2

UnificationXref1559
type: UnificationXref
id: CHEBI:16749
db: ChEBI

UnificationXref1558
type: UnificationXref
id: REACT_123619
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123619.1

Stoichiometry537
type: Stoichiometry
physical entity: SmallMolecule438
stoichiometric coefficient: 1.0

UnificationXref1557
type: UnificationXref
id: 2046054
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046054

http://identifiers.org/pubmed/10413847
type: PublicationXref
id: 10413847
author: Bläker, M
author: de Weerth, A
author: von Schrenck, T
db: Pubmed
title: [Receptors for cholecystokinin and gastrin]
source: Z Gastroenterol 37:389-401
year: 1999

Stoichiometry536
type: Stoichiometry
physical entity: Protein732
stoichiometric coefficient: 1.0

UnificationXref1556
type: UnificationXref
id: CHEBI:63540
db: ChEBI

UnificationXref369
type: UnificationXref
id: REACT_113809
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113809.8

UnificationXref368
type: UnificationXref
id: 4233580
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233580

UnificationXref367
type: UnificationXref
id: 4233578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233578

UnificationXref366
type: UnificationXref
id: P96910
db: UniProt

Stoichiometry522
type: Stoichiometry
physical entity: Protein723
stoichiometric coefficient: 1.0

UnificationXref1542
type: UnificationXref
id: 1524072
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524072

Stoichiometry521
type: Stoichiometry
physical entity: SmallMolecule441
stoichiometric coefficient: 1.0

UnificationXref1541
type: UnificationXref
id: CHEBI:28494
db: ChEBI

Stoichiometry524
type: Stoichiometry
physical entity: SmallMolecule346
stoichiometric coefficient: 1.0

UnificationXref1544
type: UnificationXref
id: 4235533
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235533

UnificationXref360
type: UnificationXref
id: CHEBI:17118
db: ChEBI

Stoichiometry523
type: Stoichiometry
physical entity: Complex255
stoichiometric coefficient: 2.0

UnificationXref1543
type: UnificationXref
id: REACT_125475
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125475.1

UnificationXref361
type: UnificationXref
id: 29590
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29590

UnificationXref362
type: UnificationXref
id: REACT_3779
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3779.3

UnificationXref363
type: UnificationXref
id: CHEBI:17973
db: ChEBI

Stoichiometry520
type: Stoichiometry
physical entity: SmallMolecule441
stoichiometric coefficient: 1.0

UnificationXref1540
type: UnificationXref
id: REACT_123458
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123458.1

UnificationXref364
type: UnificationXref
id: 30170
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30170

UnificationXref365
type: UnificationXref
id: REACT_3933
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3933.1

Stoichiometry529
type: Stoichiometry
physical entity: Protein726
stoichiometric coefficient: 1.0

UnificationXref1549
type: UnificationXref
id: 4236114
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236114

Stoichiometry526
type: Stoichiometry
physical entity: SmallMolecule441
stoichiometric coefficient: 1.0

UnificationXref1546
type: UnificationXref
id: REACT_146775
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146775.5

Stoichiometry525
type: Stoichiometry
physical entity: Protein724
stoichiometric coefficient: 1.0

UnificationXref1545
type: UnificationXref
id: 4235535
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235535

Stoichiometry528
type: Stoichiometry
physical entity: Complex258
stoichiometric coefficient: 2.0

UnificationXref1548
type: UnificationXref
id: REACT_129955
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129955.5

Stoichiometry527
type: Stoichiometry
physical entity: Protein725
stoichiometric coefficient: 1.0

UnificationXref1547
type: UnificationXref
id: 4236331
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236331

http://identifiers.org/pubmed/6785752
type: PublicationXref
id: 6785752
author: Nelson-Rees, WA
author: Carson, DA
author: Kamatani, N
db: Pubmed
title: Selective killing of human malignant cell lines deficient in methylthioadenosine phosphorylase, a purine metabolic enzyme
source: Proc Natl Acad Sci U S A 78:1219-23
year: 1981

UnificationXref356
type: UnificationXref
id: 4236064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236064

UnificationXref355
type: UnificationXref
id: REACT_80233
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80233.9

UnificationXref358
type: UnificationXref
id: 4236058
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236058

UnificationXref357
type: UnificationXref
id: REACT_28308
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28308.10

UnificationXref359
type: UnificationXref
id: REACT_99558
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99558.9

UnificationXref1578
type: UnificationXref
id: REACT_123067
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123067.1

UnificationXref1579
type: UnificationXref
id: 4235771
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235771

UnificationXref1572
type: UnificationXref
id: 2066765
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066765

UnificationXref1573
type: UnificationXref
id: REACT_124023
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124023.1

UnificationXref1570
type: UnificationXref
id: REACT_124098
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124098.1

UnificationXref1571
type: UnificationXref
id: CHEBI:65132
db: ChEBI

UnificationXref1576
type: UnificationXref
id: CHEBI:28125
db: ChEBI

UnificationXref1577
type: UnificationXref
id: 2066763
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066763

UnificationXref1574
type: UnificationXref
id: 4235772
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235772

http://identifiers.org/pubmed/13211603
type: PublicationXref
id: 13211603
author: Joklik, WK
author: Berg, P
db: Pubmed
title: Enzymatic phosphorylation of nucleoside diphosphates
source: J Biol Chem 210:657-672
year: 1954

UnificationXref1575
type: UnificationXref
id: REACT_137688
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137688.5

UnificationXref1567
type: UnificationXref
id: REACT_146633
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146633.5

UnificationXref1568
type: UnificationXref
id: CHEBI:65131
db: ChEBI

UnificationXref1569
type: UnificationXref
id: 2066762
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066762

UnificationXref1560
type: UnificationXref
id: 426639
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426639

UnificationXref1561
type: UnificationXref
id: REACT_123561
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123561.1

UnificationXref1562
type: UnificationXref
id: 211606
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211606

UnificationXref1563
type: UnificationXref
id: REACT_23217
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23217.1

UnificationXref1564
type: UnificationXref
id: 2046047
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046047

UnificationXref1565
type: UnificationXref
id: REACT_124358
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124358.1

UnificationXref1566
type: UnificationXref
id: 4235769
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235769

http://identifiers.org/pubmed/11278511
type: PublicationXref
id: 11278511
author: Ding, WC
author: Berger, SH
author: Lebioda, L
author: Koli, S
author: Minor, W
author: Dunlap, RB
author: Phan, J
author: Steadman, DJ
db: Pubmed
title: Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
source: J Biol Chem 276:14170-7
year: 2001

http://identifiers.org/pubmed/7493035
type: PublicationXref
id: 7493035
author: Morris, CP
author: Hopwood, JJ
author: Blanch, L
author: Guo, XH
author: Sutherland, GR
author: Freeman, C
author: Baker, E
author: Orsborn, A
author: Scott, HS
db: Pubmed
title: Cloning of the sulphamidase gene and identification of mutations in Sanfilippo A syndrome
source: Nat Genet 11:465-7
year: 1995

UnificationXref1598
type: UnificationXref
id: 31593
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31593

UnificationXref1599
type: UnificationXref
id: REACT_2519
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2519.3

UnificationXref1596
type: UnificationXref
id: REACT_3060
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3060.2

UnificationXref1597
type: UnificationXref
id: CHEBI:15552
db: ChEBI

UnificationXref1594
type: UnificationXref
id: CHEBI:15554
db: ChEBI

UnificationXref1595
type: UnificationXref
id: 30138
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30138

UnificationXref1592
type: UnificationXref
id: 4236355
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236355

UnificationXref1593
type: UnificationXref
id: REACT_139965
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139965.5

UnificationXref1591
type: UnificationXref
id: REACT_127969
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127969.5

UnificationXref1590
type: UnificationXref
id: 4236356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236356

http://identifiers.org/pubmed/15788652
type: PublicationXref
id: 15788652
author: Kadler, Karl E
author: Canty, Elizabeth G
db: Pubmed
title: Procollagen trafficking, processing and fibrillogenesis
source: J. Cell. Sci. 118:1341-53
year: 2005

UnificationXref1589
type: UnificationXref
id: REACT_138965
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138965.5

UnificationXref1585
type: UnificationXref
id: REACT_123419
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123419.1

UnificationXref1586
type: UnificationXref
id: 2046055
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046055

UnificationXref1587
type: UnificationXref
id: REACT_123939
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123939.1

UnificationXref1588
type: UnificationXref
id: 4235770
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235770

UnificationXref1581
type: UnificationXref
id: 4236354
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236354

UnificationXref1582
type: UnificationXref
id: REACT_128527
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128527.5

http://identifiers.org/pubmed/10536157
type: PublicationXref
id: 10536157
author: Wu, X
author: Zhang, Y
author: Xin, H
author: Lin, W
author: Yuan, F
db: Pubmed
title: The human REV1 gene codes for a DNA template-dependent dCMP transferase.
source: Nucleic Acids Res 27:4468-75
year: 1999

UnificationXref1583
type: UnificationXref
id: CHEBI:63546
db: ChEBI

UnificationXref1584
type: UnificationXref
id: 2046050
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046050

UnificationXref399
type: UnificationXref
id: 4233598
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233598

http://identifiers.org/pubmed/18538142
type: PublicationXref
id: 18538142
author: Hunt, MC
author: Alexson, SE
db: Pubmed
title: Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism
source: Prog Lipid Res 47:405-21
year: 2008

UnificationXref1580
type: UnificationXref
id: REACT_140334
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140334.5

http://identifiers.org/pubmed/15837520
type: PublicationXref
id: 15837520
author: Wess, TJ
db: Pubmed
title: Collagen fibril form and function
source: Adv Protein Chem 70:341-74
year: 2005

http://identifiers.org/pubmed/15837523
type: PublicationXref
id: 15837523
author: Weiss, Anthony S
author: Mithieux, Suzanne M
db: Pubmed
title: Elastin
source: Adv. Protein Chem. 70:437-61
year: 2005

http://identifiers.org/pubmed/9176399
type: PublicationXref
id: 9176399
author: Hägg, PO
author: Hägg, PM
author: Autio-Harmainen, H
author: Pihlajaniemi, T
author: Peltonen, S
db: Pubmed
title: Location of type XV collagen in human tissues and its accumulation in the interstitial matrix of the fibrotic kidney
source: Am J Pathol 150:2075-86
year: 1997

http://identifiers.org/pubmed/21781017
type: PublicationXref
id: 21781017
author: Pulimeno, P
author: Stutz, J
author: Spadaro, D
author: Schneider, Y
author: Citi, S
db: Pubmed
title: Regulation of small GTPases at epithelial cell-cell junctions
source: Mol Membr Biol
year: 2011

http://identifiers.org/pubmed/13115431
type: PublicationXref
id: 13115431
author: Lieberman, I
author: Kornberg, A
db: Pubmed
title: Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase
source: Biochim Biophys Acta 12:223-234
year: 1953

http://identifiers.org/pubmed/16564093
type: PublicationXref
id: 16564093
author: Jacobsson, A
author: Jakobsson, A
author: Westerberg, R
db: Pubmed
title: Fatty acid elongases in mammals: their regulation and roles in metabolism
source: Prog Lipid Res 45:237-49
year: 2006

UnificationXref1702
type: UnificationXref
id: CHEBI:61011
db: ChEBI

UnificationXref1701
type: UnificationXref
id: REACT_161537
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161537.1

UnificationXref1700
type: UnificationXref
id: 2162256
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162256

UnificationXref1706
type: UnificationXref
id: REACT_7747
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7747.2

UnificationXref1705
type: UnificationXref
id: 159450
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159450

UnificationXref1704
type: UnificationXref
id: REACT_161199
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161199.1

UnificationXref1703
type: UnificationXref
id: 2162214
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162214

http://identifiers.org/pubmed/12514191
type: PublicationXref
id: 12514191
author: Bobik, TA
author: Park, Sanghee D
author: Kima, Peter E
author: Leal, Nicole A
db: Pubmed
title: Identification of the human and bovine ATP:Cob(I)alamin adenosyltransferase cDNAs based on complementation of a bacterial mutant
source: J. Biol. Chem. 278:9227-34
year: 2003

http://identifiers.org/pubmed/13295248
type: PublicationXref
id: 13295248
author: Stern, JR
author: Del Campillo, A
db: Pubmed
title: Enzymes of fatty acid metabolism. II. Properties of crystalline crotonase.
source: J Biol Chem 218:985-1002
year: 1956

UnificationXref1707
type: UnificationXref
id: O06428
db: UniProt

UnificationXref1708
type: UnificationXref
id: 4235829
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235829

UnificationXref1709
type: UnificationXref
id: O05572
db: UniProt

http://identifiers.org/pubmed/22952392
type: PublicationXref
id: 22952392
author: Nusse, Roel
author: Willert, Karl
db: Pubmed
title: Wnt proteins
source: Cold Spring Harb Perspect Biol 4:a007864
year: 2012

UnificationXref1711
type: UnificationXref
id: 4235831
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235831

UnificationXref1710
type: UnificationXref
id: 4235830
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235830

UnificationXref1713
type: UnificationXref
id: REACT_3508
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3508.3

UnificationXref1712
type: UnificationXref
id: 109496
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109496

UnificationXref1715
type: UnificationXref
id: 4235826
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235826

UnificationXref1714
type: UnificationXref
id: 4235823
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235823

UnificationXref1717
type: UnificationXref
id: 4235828
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235828

UnificationXref1716
type: UnificationXref
id: 4235827
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235827

http://identifiers.org/pubmed/5324173
type: PublicationXref
id: 5324173
author: Berg, P
author: Baldwin, AN
db: Pubmed
title: Transfer ribonucleic acid-induced hydrolysis of valyladenylate bound to isoleucyl ribonucleic acid synthetase
source: J Biol Chem 241:839-45
year: 1966

http://identifiers.org/pubmed/5324172
type: PublicationXref
id: 5324172
author: Berg, P
author: Baldwin, AN
db: Pubmed
title: Purification and properties of isoleucyl ribonucleic acid synthetase from Escherichia coli
source: J Biol Chem 241:831-8
year: 1966

http://identifiers.org/pubmed/1592113
type: PublicationXref
id: 1592113
author: Powell, SM
author: Dixon, JE
author: Zalkin, H
db: Pubmed
title: Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase
source: FEBS Lett 303:4-20
year: 1992

photoreceptor outer segment membrane
type: CellularLocationVocabulary
xref: UnificationXref3544

Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction68
pathway component: BiochemicalReaction69
pathway component: BiochemicalReaction70
evidence: Evidence132
xref: UnificationXref878
xref: RelationshipXref115
xref: UnificationXref877
pathway order: PathwayStep127
pathway order: PathwayStep128
pathway order: PathwayStep129
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/18400693
type: PublicationXref
id: 18400693
author: Dorwart, MR
author: Muallem, S
author: Yang, D
author: Shcheynikov, N
db: Pubmed
title: The solute carrier 26 family of proteins in epithelial ion transport
source: Physiology (Bethesda) 23:104-14
year: 2008

UnificationXref1741
type: UnificationXref
id: 4234475
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234475

UnificationXref1742
type: UnificationXref
id: REACT_131160
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131160.5

UnificationXref1740
type: UnificationXref
id: REACT_99445
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99445.9

UnificationXref1745
type: UnificationXref
id: 4234473
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234473

UnificationXref1746
type: UnificationXref
id: REACT_156982
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156982.3

MPS IX - Natowicz syndrome
type: Pathway
data source: Provenance1
pathway component: REACT 134911.5
evidence: Evidence513
xref: UnificationXref3540
xref: UnificationXref3541
pathway order: PathwayStep84
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1743
type: UnificationXref
id: 4234472
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234472

UnificationXref1744
type: UnificationXref
id: REACT_159325
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159325.3

UnificationXref1749
type: UnificationXref
id: 4236192
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236192

UnificationXref1747
type: UnificationXref
id: 4236191
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236191

UnificationXref1748
type: UnificationXref
id: REACT_31270
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31270.10

http://identifiers.org/pubmed/2462567
type: PublicationXref
id: 2462567
author: de Jong, WW
author: Stapel, SO
author: Lietman, T
author: Wistow, GJ
author: Piatigorsky, J
author: Williams, LA
author: Horwitz, J
db: Pubmed
title: Tau-crystallin/alpha-enolase: one gene encodes both an enzyme and a lens structural protein
source: J Cell Biol 107:2729-36
year: 1988

UnificationXref1750
type: UnificationXref
id: REACT_83420
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83420.9

UnificationXref1751
type: UnificationXref
id: CHEBI:18372
db: ChEBI

UnificationXref1752
type: UnificationXref
id: 1474124
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1474124

UnificationXref1753
type: UnificationXref
id: REACT_111890
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111890.1

UnificationXref1754
type: UnificationXref
id: P64207
db: UniProt

UnificationXref1755
type: UnificationXref
id: 4235503
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235503

UnificationXref1756
type: UnificationXref
id: 4235504
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235504

UnificationXref1757
type: UnificationXref
id: 4235505
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235505

UnificationXref1758
type: UnificationXref
id: 4235507
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235507

UnificationXref1759
type: UnificationXref
id: REACT_134921
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134921.5

http://identifiers.org/pubmed/12324224
type: PublicationXref
id: 12324224
author: Sprecher, H
db: Pubmed
title: The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids
source: Prostaglandins Leukot Essent Fatty Acids 67:79-83
year: 2002

http://identifiers.org/pubmed/11274208
type: PublicationXref
id: 11274208
author: Woodley, DT
author: Costa, FK
author: Tahk, SH
author: Keene, DR
author: Chen, M
db: Pubmed
title: The carboxyl terminus of type VII collagen mediates antiparallel dimer formation and constitutes a new antigenic epitope for epidermolysis Bullosa acquisita autoantibodies
source: J Biol Chem 276:21649-55
year: 2001

http://identifiers.org/pubmed/19962385
type: PublicationXref
id: 19962385
author: Michot, N
author: Mathieu, M
author: Cheuret, D
author: Rak, A
author: Augé, F
author: Hoornaert, C
author: Berne, PF
author: Vallée, F
author: Houtmann, J
author: Bertrand, T
author: Mikol, V
db: Pubmed
title: Structural basis for human monoglyceride lipase inhibition
source: J Mol Biol 396:663-73
year: 2010

UnificationXref1719
type: UnificationXref
id: 4235834
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235834

UnificationXref1718
type: UnificationXref
id: 4235832
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235832

UnificationXref1720
type: UnificationXref
id: REACT_163471
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_163471.2

UnificationXref1727
type: UnificationXref
id: CHEBI:64181
db: ChEBI

UnificationXref1728
type: UnificationXref
id: 2162204
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162204

UnificationXref1725
type: UnificationXref
id: 2162265
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162265

UnificationXref1726
type: UnificationXref
id: REACT_160998
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160998.1

http://identifiers.org/pubmed/17095732
type: PublicationXref
id: 17095732
author: Oram, JF
author: Vaughan, AM
db: Pubmed
title: ATP-Binding cassette cholesterol transporters and cardiovascular disease
source: Circ Res 99:1031-43
year: 2006

UnificationXref1723
type: UnificationXref
id: REACT_161345
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161345.1

UnificationXref1724
type: UnificationXref
id: CHEBI:15414
db: ChEBI

UnificationXref1721
type: UnificationXref
id: CHEBI:64180
db: ChEBI

UnificationXref1722
type: UnificationXref
id: 2162205
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162205

http://identifiers.org/pubmed/19021507
type: PublicationXref
id: 19021507
author: Johnson, MK
author: Chandramouli, K
author: Bandyopadhyay, S
db: Pubmed
title: Iron-sulfur cluster biosynthesis
source: Biochem Soc Trans 36:1112-9
year: 2008

lanosterol
type: SmallMolecule
entity reference: CHEBI:16521
data source: Provenance1
xref: UnificationXref1257
xref: UnificationXref1256
cellular location: GO:0005789
comment: Reactome DB_ID: 194634
display name: LNSOL

Dimethylallyl pyrophosphate
type: SmallMolecule
entity reference: CHEBI:16057
data source: Provenance1
xref: UnificationXref1249
xref: UnificationXref1248
cellular location: GO:0005829
comment: Reactome DB_ID: 191324
display name: DMAPP

UnificationXref1729
type: UnificationXref
id: REACT_161541
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161541.1

http://identifiers.org/pubmed/14602708
type: PublicationXref
id: 14602708
author: Pietka, T
author: Eyre, DR
author: Wu, JJ
author: Weis, MA
db: Pubmed
title: Covalent cross-linking of the NC1 domain of collagen type IX to collagen type II in cartilage
source: J Biol Chem 279:2568-74
year: 2004

http://identifiers.org/pubmed/9188776
type: PublicationXref
id: 9188776
author: Rider, MH
author: Veiga-da-Cunha, M
author: Gerin, I
author: Van Schaftingen, E
author: Collet, JF
db: Pubmed
title: Human L-3-phosphoserine phosphatase: sequence, expression and evidence for a phosphoenzyme intermediate
source: FEBS Lett 408:281-4
year: 1997

UnificationXref1730
type: UnificationXref
id: CHEBI:16680
db: ChEBI

UnificationXref1731
type: UnificationXref
id: 2162252
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162252

UnificationXref1736
type: UnificationXref
id: REACT_163001
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_163001.2

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Provenance1
xref: UnificationXref1223
xref: UnificationXref1224
cellular location: GO:0005782
comment: Reactome DB_ID: 193465

UnificationXref1737
type: UnificationXref
id: 4236362
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236362

Oxoglutaric acid
type: SmallMolecule
entity reference: CHEBI:30915
data source: Provenance1
name: 2-Oxoglutarate
name: alpha-Ketoglutaric acid
name: 2-Ketoglutaric acid
xref: UnificationXref1226
xref: UnificationXref1227
cellular location: GO:0005782
comment: Reactome DB_ID: 389537
display name: 2OG

UnificationXref1738
type: UnificationXref
id: REACT_161995
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161995.2

NADP+
type: SmallMolecule
entity reference: NADP+
data source: Provenance1
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref1220
xref: UnificationXref1219
cellular location: GO:0005782
comment: Reactome DB_ID: 389556
display name: TPN

UnificationXref1739
type: UnificationXref
id: 4236078
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236078

NADPH
type: SmallMolecule
entity reference: CHEBI:16474
data source: Provenance1
xref: UnificationXref1222
xref: UnificationXref1221
cellular location: GO:0005782
comment: Reactome DB_ID: 113602
display name: TPNH

UnificationXref1732
type: UnificationXref
id: REACT_161327
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161327.1

2-oxoglutarate
type: SmallMolecule
entity reference: CHEBI:30915
data source: Provenance1
name: alpha-ketoglutarate
name: Oxoglutaric acid
name: 2-Oxoglutarate
name: alpha-Ketoglutaric acid
name: 2-Ketoglutaric acid
xref: UnificationXref1238
xref: UnificationXref1237
cellular location: GO:0005829
comment: Reactome DB_ID: 29406
display name: 2OG

UnificationXref1733
type: UnificationXref
id: P0A638
db: UniProt

delta3-isopentenyl pyrophosphate
type: SmallMolecule
entity reference: CHEBI:16584
data source: Provenance1
xref: UnificationXref1245
xref: UnificationXref1246
cellular location: GO:0005829
comment: Reactome DB_ID: 191362
display name: IPPP

UnificationXref1734
type: UnificationXref
id: 4235818
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235818

Carbon dioxide
type: SmallMolecule
entity reference: CHEBI:16526
data source: Provenance1
xref: UnificationXref1228
xref: UnificationXref1229
cellular location: GO:0005782
comment: Reactome DB_ID: 389536
display name: CO2

http://identifiers.org/pubmed/16968945
type: PublicationXref
id: 16968945
author: Kontush, A
author: Chapman, MJ
db: Pubmed
title: Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis
source: Pharmacol Rev 58:342-74
year: 2006

UnificationXref1735
type: UnificationXref
id: 4235820
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235820

1-Hydroxytricarballylic acid
type: SmallMolecule
entity reference: D-threo-Isocitric acid
data source: Provenance1
name: 1-Hydroxypropane-1,2,3-tricarboxylic acid
name: D-erythro-Isocitric acid
name: D-threo-Isocitric acid
name: Isocitric acid
name: Isocitrate
name: (1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylate
xref: UnificationXref1235
xref: UnificationXref1236
cellular location: GO:0005829
comment: Reactome DB_ID: 389545
display name: ISCIT

RelationshipXref327
type: RelationshipXref
id: GO:0036222
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref328
type: RelationshipXref
id: 4236006
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236006

4-Trimethylammoniobutanal
type: SmallMoleculeReference
name: 4-Trimethylammoniobutanal [ChEBI:18020]
xref: UnificationXref2874

Hexanoyl-CoA
type: SmallMoleculeReference
name: Hexanoyl-CoA [ChEBI:27540]
xref: UnificationXref892

RelationshipXref329
type: RelationshipXref
id: GO:0055086
db: GENE ONTOLOGY
relationship type: MI:0359

Phosphoenolpyruvic acid
type: SmallMoleculeReference
name: Phosphoenolpyruvate
name: Phosphoenolpyruvate [ChEBI:18021]
name: PEP
xref: UnificationXref232

RelationshipXref320
type: RelationshipXref
id: 4235169
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235169

RelationshipXref321
type: RelationshipXref
id: 4235174
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235174

RelationshipXref322
type: RelationshipXref
id: GO:0015949
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref323
type: RelationshipXref
id: GO:0036220
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref324
type: RelationshipXref
id: 4236003
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236003

RelationshipXref325
type: RelationshipXref
id: GO:0035870
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref326
type: RelationshipXref
id: 4236009
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236009

http://identifiers.org/pubmed/20980607
type: PublicationXref
id: 20980607
author: Avila, Robin L
author: Kallio, Mika
author: Stavén, Saara
author: Tolonen, Uolevi
author: Tanila, Heikki
author: Soininen, Raija
author: Huhtala, Pirkko
author: Rasi, Karolina
author: Heape, Anthony M
author: Kirschner, Daniel
author: Pihlajaniemi, Taina
author: Sormunen, Raija
author: Muona, Anu
author: Hurskainen, Merja
db: Pubmed
title: Lack of collagen XV impairs peripheral nerve maturation and, when combined with laminin-411 deficiency, leads to basement membrane abnormalities and sensorimotor dysfunction
source: J. Neurosci. 30:14490-501
year: 2010

RelationshipXref318
type: RelationshipXref
id: 4234373
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234373

UniProt:P63715
type: ProteinReference
xref: UnificationXref3154
organism: BioSource1

RelationshipXref319
type: RelationshipXref
id: GO:0004550
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref316
type: RelationshipXref
id: 4234357
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234357

UniProt:P63717
type: ProteinReference
xref: UnificationXref3150
organism: BioSource1

RelationshipXref317
type: RelationshipXref
id: GO:0004748
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref310
type: RelationshipXref
id: GO:0043097
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref311
type: RelationshipXref
id: GO:0046135
db: GENE ONTOLOGY
relationship type: MI:0359

diacylglycerols
type: SmallMoleculeReference
name: diacylglycerols [ChEBI:18035]
xref: UnificationXref587

RelationshipXref314
type: RelationshipXref
id: 4234256
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234256

UniProt:P63719
type: ProteinReference
xref: UnificationXref3152
organism: BioSource1

RelationshipXref315
type: RelationshipXref
id: GO:0036175
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref312
type: RelationshipXref
id: GO:0006206
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref313
type: RelationshipXref
id: GO:0004017
db: GENE ONTOLOGY
relationship type: MI:0355

trans-Oct-2-enoyl-CoA [ChEBI:27537]
type: SmallMoleculeReference
name: trans-Oct-2-enoyl-CoA
xref: UnificationXref879

RelationshipXref309
type: RelationshipXref
id: 4233918
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233918

4-Aminosalicylate
type: SmallMoleculeReference
name: 4-Aminosalicylic acid
name: 4-Aminosalicylate [ChEBI:1789]
xref: UnificationXref3271

RelationshipXref305
type: RelationshipXref
id: GO:0046134
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref306
type: RelationshipXref
id: GO:0016763
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref307
type: RelationshipXref
id: 4234432
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234432

RelationshipXref308
type: RelationshipXref
id: GO:0004126
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref301
type: RelationshipXref
id: GO:0004170
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref302
type: RelationshipXref
id: 4233937
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233937

RelationshipXref303
type: RelationshipXref
id: GO:0004799
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref304
type: RelationshipXref
id: 4233912
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233912

RelationshipXref300
type: RelationshipXref
id: 4233881
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233881

1-thioglycine
type: SequenceModificationVocabulary
xref: UnificationXref2594

GABA synthesis, release, reuptake and degradation
type: Pathway
data source: Provenance1
pathway component: REACT 131502.5
evidence: Evidence533
xref: UnificationXref3641
xref: UnificationXref3640
pathway order: PathwayStep525
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

L-Glutamine
type: SmallMoleculeReference
name: L-Glutamine [ChEBI:18050]
name: L-2-Aminoglutaramic acid
xref: UnificationXref55

http://identifiers.org/pubmed/17956313
type: PublicationXref
id: 17956313
author: Herbert, TP
db: Pubmed
title: PERK in the life and death of the pancreatic beta-cell
source: Biochem Soc Trans 35:1205-7
year: 2007

phosphofructokinase, L4 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry4
component: Protein24
xref: UnificationXref178
cellular location: GO:0005622
comment: Reactome DB_ID: 4233614

phosphofructokinase tetramer
type: Complex
data source: Provenance1
member physical entity: phosphofructokinase, P2L2 complex (name copied from entity in Homo sapiens)
member physical entity: phosphofructokinase, PL3 complex (name copied from entity in Homo sapiens)
member physical entity: phosphofructokinase, L4 complex (name copied from entity in Homo sapiens)
member physical entity: phosphofructokinase, P4 complex (name copied from entity in Homo sapiens)
member physical entity: phosphofructokinase, P3L complex (name copied from entity in Homo sapiens)
xref: UnificationXref184
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4233620

phosphofructokinase, P3L complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry7
component stoichiometry: Stoichiometry6
component: Protein25
component: Protein24
xref: UnificationXref181
cellular location: GO:0005622
comment: Reactome DB_ID: 4233617

phosphofructokinase, P4 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry5
component: Protein25
xref: UnificationXref180
cellular location: GO:0005622
comment: Reactome DB_ID: 4233616

phosphofructokinase, PL3 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry11
component stoichiometry: Stoichiometry10
component: Protein25
component: Protein24
xref: UnificationXref183
cellular location: GO:0005622
comment: Reactome DB_ID: 4233619

phosphofructokinase, P2L2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry9
component stoichiometry: Stoichiometry8
component: Protein25
component: Protein24
xref: UnificationXref182
cellular location: GO:0005622
comment: Reactome DB_ID: 4233618

L-arginine removal
type: SequenceModificationVocabulary
xref: UnificationXref3565

triosephosphate isomerase dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry12
component: Protein26
xref: UnificationXref209
cellular location: GO:0005622
comment: Reactome DB_ID: 4233608

http://identifiers.org/pubmed/9693067
type: PublicationXref
id: 9693067
author: Bader, B
author: Löffler, M
author: Fries, M
author: Knecht, W
db: Pubmed
title: Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase.
source: Protein Expr Purif 13:414-22
year: 1998

SUMF1:SUMF2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2
component stoichiometry: Stoichiometry1
component: SUMF2_HUMAN
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref47
cellular location: GO:0005622
comment: Reactome DB_ID: 4235563

glucose 6-phosphate isomerase dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry3
component: Protein23
xref: UnificationXref164
cellular location: GO:0005622
comment: Reactome DB_ID: 4233631

RelationshipXref364
type: RelationshipXref
id: 4233838
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233838

RelationshipXref363
type: RelationshipXref
id: GO:0004372
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref366
type: RelationshipXref
id: GO:0070283
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref365
type: RelationshipXref
id: GO:0046655
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref368
type: RelationshipXref
id: GO:0030366
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref367
type: RelationshipXref
id: 4235345
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235345

RelationshipXref369
type: RelationshipXref
id: 4235370
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235370

UDPglucose
type: SmallMoleculeReference
name: UDP-D-glucose
name: UDPglucose [ChEBI:18066]
name: UDP-glucose
xref: UnificationXref370

RelationshipXref360
type: RelationshipXref
id: 4234781
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234781

RelationshipXref361
type: RelationshipXref
id: GO:0004486
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref362
type: RelationshipXref
id: 4234778
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234778

RelationshipXref355
type: RelationshipXref
id: GO:0004326
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref354
type: RelationshipXref
id: GO:0019674
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref353
type: RelationshipXref
id: GO:0006769
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref352
type: RelationshipXref
id: 4234674
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234674

RelationshipXref359
type: RelationshipXref
id: GO:0004477
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref358
type: RelationshipXref
id: 4234785
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234785

RelationshipXref357
type: RelationshipXref
id: GO:0004329
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref356
type: RelationshipXref
id: 4234697
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234697

http://identifiers.org/pubmed/17498549
type: PublicationXref
id: 17498549
author: Antonicelli, F
author: Bellon, G
author: Debelle, L
author: Hornebeck, W
db: Pubmed
title: Elastin-elastases and inflamm-aging
source: Curr Top Dev Biol 79:99-155
year: 2007

dTDP
type: SmallMoleculeReference
name: Deoxythymidine 5'-diphosphate
name: dTDP [ChEBI:18075]
xref: UnificationXref2287

TTP
type: SmallMoleculeReference
name: Deoxythymidine 5'-triphosphate
name: dTTP
name: Deoxythymidine triphosphate
name: dTTP [ChEBI:18077]
xref: UnificationXref2304

Metabolism of nucleotides
type: Pathway
data source: Provenance1
pathway component: Pyrimidine metabolism
pathway component: BiochemicalReaction199
pathway component: BiochemicalReaction198
pathway component: REACT 89651.9
pathway component: BiochemicalReaction200
pathway component: REACT 98747.9
evidence: Evidence336
xref: UnificationXref2383
xref: RelationshipXref329
xref: UnificationXref2382
pathway order: PathwayStep304
pathway order: PathwayStep332
pathway order: PathwayStep330
pathway order: PathwayStep319
pathway order: PathwayStep331
pathway order: PathwayStep333
display name: Nucleotide metabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref350
type: RelationshipXref
id: 4234681
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234681

RelationshipXref351
type: RelationshipXref
id: GO:0004516
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref346
type: RelationshipXref
id: 4234686
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234686

RelationshipXref345
type: RelationshipXref
id: GO:0004514
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref348
type: RelationshipXref
id: 4234692
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234692

RelationshipXref347
type: RelationshipXref
id: GO:0003952
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref342
type: RelationshipXref
id: 4236036
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236036

RelationshipXref341
type: RelationshipXref
id: GO:0015420
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref344
type: RelationshipXref
id: GO:0006768
db: GENE ONTOLOGY
relationship type: MI:0359

Recycling of bile acids and salts
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction116
pathway component: BiochemicalReaction128
evidence: Evidence219
xref: UnificationXref1472
xref: RelationshipXref187
xref: UnificationXref1473
pathway order: PathwayStep216
pathway order: PathwayStep200
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/13295225
type: PublicationXref
id: 13295225
author: Crane, FL
author: Beinert, H
db: Pubmed
title: On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. II. The electron-transferring flavoprotein.
source: J Biol Chem 218:717-31
year: 1956

RelationshipXref343
type: RelationshipXref
id: GO:0009235
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref349
type: RelationshipXref
id: GO:0003951
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref340
type: RelationshipXref
id: 4236044
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236044

RelationshipXref337
type: RelationshipXref
id: GO:0050453
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref336
type: RelationshipXref
id: GO:0042816
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref335
type: RelationshipXref
id: 4235381
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235381

RelationshipXref334
type: RelationshipXref
id: GO:0004733
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref333
type: RelationshipXref
id: GO:0015939
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref332
type: RelationshipXref
id: GO:0009108
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref331
type: RelationshipXref
id: 4234664
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234664

RelationshipXref330
type: RelationshipXref
id: GO:0004633
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref339
type: RelationshipXref
id: GO:0008817
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/18772286
type: PublicationXref
id: 18772286
author: Buchmeier, N
author: Newton, GL
author: Fahey, RC
db: Pubmed
title: Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria
source: Microbiol Mol Biol Rev 72:471-94
year: 2008

RelationshipXref338
type: RelationshipXref
id: 4236042
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236042

http://identifiers.org/pubmed/10583946
type: PublicationXref
id: 10583946
author: Wood, RD
author: Lindahl, T
db: Pubmed
title: Quality control by DNA repair
source: Science 286:1897-905
year: 1999

RelationshipXref272
type: RelationshipXref
id: GO:0004019
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref271
type: RelationshipXref
id: 4233942
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233942

RelationshipXref274
type: RelationshipXref
id: GO:0009168
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref273
type: RelationshipXref
id: 4234338
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234338

RelationshipXref270
type: RelationshipXref
id: GO:0003921
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/15207811
type: PublicationXref
id: 15207811
author: Li, H
author: Fredriksson, L
author: Eriksson, U
db: Pubmed
title: The PDGF family: four gene products form five dimeric isoforms
source: Cytokine Growth Factor Rev 15:197-204
year: 2004

RelationshipXref279
type: RelationshipXref
id: 4234038
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234038

RelationshipXref275
type: RelationshipXref
id: GO:0004000
db: GENE ONTOLOGY
relationship type: MI:0355

Sulfur compound metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 27187.1
pathway component: REACT 27155.1
xref: RelationshipXref739
xref: UnificationXref5304
xref: UnificationXref5305
xref: http://identifiers.org/pubmed/17970225
pathway order: PathwayStep784
pathway order: PathwayStep772
comment: Authored: Stephan, R, 2010-06-17
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
comment: Unique small sulfur compounds, as well as unique pathways to sulfur amino acids are known in Mycobacteria. Sulfoglycolipids and mycothiols are an important part of the hardy pathogen nature of these organisms. Their pathways make interesting targets for drug designers (Bhave et al, 2007).
organism: BioSource1

RelationshipXref276
type: RelationshipXref
id: 4234032
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234032

RelationshipXref277
type: RelationshipXref
id: 4235798
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235798

RelationshipXref278
type: RelationshipXref
id: GO:0004731
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref285
type: RelationshipXref
id: 4235202
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235202

lysophosphatidic acid
type: SmallMolecule
entity reference: CHEBI:16975
data source: Provenance1
name: 1-acyl-glycerol 3-phosphate
xref: UnificationXref734
xref: UnificationXref735
cellular location: GO:0005829
comment: Reactome DB_ID: 76112
display name: 1-acyl LPA

RelationshipXref284
type: RelationshipXref
id: GO:0003920
db: GENE ONTOLOGY
relationship type: MI:0355

lysophosphatidic acid
type: SmallMolecule
entity reference: CHEBI:16975
data source: Provenance1
name: 1-acyl-glycerol 3-phosphate
xref: UnificationXref745
xref: UnificationXref746
cellular location: GO:0005789
comment: Reactome DB_ID: 1500604
display name: 1-acyl LPA

RelationshipXref283
type: RelationshipXref
id: 4234027
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234027

acyl-CoA
type: SmallMolecule
entity reference: CHEBI:17984
data source: Provenance1
xref: UnificationXref748
xref: UnificationXref749
cellular location: GO:0005829
comment: Reactome DB_ID: 1500578

RelationshipXref282
type: RelationshipXref
id: GO:0004422
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref281
type: RelationshipXref
id: 4234021
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234021

RelationshipXref280
type: RelationshipXref
id: GO:0003999
db: GENE ONTOLOGY
relationship type: MI:0355

Acetyl coenzyme A
type: SmallMolecule
entity reference: CHEBI:15351
data source: Provenance1
name: Acetyl-CoA
xref: UnificationXref646
xref: UnificationXref645
cellular location: GO:0005829
comment: Reactome DB_ID: 76183
display name: Ac-CoA

Malonyl coenzyme A
type: SmallMolecule
entity reference: CHEBI:15531
data source: Provenance1
xref: UnificationXref699
xref: UnificationXref698
cellular location: GO:0005829
comment: Reactome DB_ID: 29508
display name: Malonyl-CoA

Palmitic acid
type: SmallMolecule
entity reference: CHEBI:15756
data source: Provenance1
name: Palmitate
xref: UnificationXref702
xref: UnificationXref703
cellular location: GO:0005769
comment: Reactome DB_ID: 76168
display name: PALM

3-oxooctadecanoyl-CoA
type: SmallMolecule
entity reference: CHEBI:50571
data source: Provenance1
xref: UnificationXref707
xref: UnificationXref708
cellular location: GO:0005829
comment: Reactome DB_ID: 548812
display name: 3-oxostearoyl-CoA

3-hydroxyoctadecanoyl-CoA
type: SmallMolecule
entity reference: CHEBI:50583
data source: Provenance1
xref: UnificationXref710
xref: UnificationXref711
cellular location: GO:0005829
comment: Reactome DB_ID: 548836

Glycerol-3-phosphate
type: SmallMolecule
entity reference: CHEBI:15978
data source: Provenance1
xref: UnificationXref725
xref: UnificationXref724
cellular location: GO:0005829
comment: Reactome DB_ID: 76114
display name: G3P

acyl-CoA
type: SmallMolecule
entity reference: CHEBI:37554
data source: Provenance1
name: fatty acyl CoA
xref: UnificationXref731
xref: UnificationXref732
cellular location: GO:0005829
comment: Reactome DB_ID: 75967
display name: FACoA

RelationshipXref288
type: RelationshipXref
id: GO:0006144
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref289
type: RelationshipXref
id: GO:0004088
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref286
type: RelationshipXref
id: GO:0043101
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref287
type: RelationshipXref
id: GO:0006195
db: GENE ONTOLOGY
relationship type: MI:0359

Signaling by EGFR in Cancer
type: Pathway
data source: Provenance1
pathway component: Epidermal Growth Factor Receptor (EGFR) signaling
pathway component: REACT 146586.5
evidence: Evidence498
xref: UnificationXref3510
xref: UnificationXref3511
pathway order: PathwayStep490
pathway order: PathwayStep492
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

5-acetamido-6-formamido-3-methyluracil
type: SmallMoleculeReference
name: ChEBI:32643 5-acetamido-6-formamido-3-methyluracil
xref: UnificationXref3303

RelationshipXref250
type: RelationshipXref
id: 4234484
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234484

RelationshipXref252
type: RelationshipXref
id: GO:0004044
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref251
type: RelationshipXref
id: GO:0022904
db: GENE ONTOLOGY
relationship type: MI:0359

Homologous Recombination Repair
type: Pathway
data source: Provenance1
pathway component: Homologous recombination repair of replication-independent double-strand breaks
evidence: Evidence646
xref: UnificationXref4310
xref: UnificationXref4311
xref: RelationshipXref588
pathway order: PathwayStep632
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref253
type: RelationshipXref
id: 4233983
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233983

RelationshipXref254
type: RelationshipXref
id: GO:0004637
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref255
type: RelationshipXref
id: 4233977
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233977

RelationshipXref256
type: RelationshipXref
id: GO:0004644
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref257
type: RelationshipXref
id: 4233975
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233975

RelationshipXref258
type: RelationshipXref
id: GO:0004642
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref259
type: RelationshipXref
id: 4233973
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233973

RelationshipXref263
type: RelationshipXref
id: 4233963
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233963

RelationshipXref262
type: RelationshipXref
id: GO:0004018
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref261
type: RelationshipXref
id: 4233968
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233968

RelationshipXref260
type: RelationshipXref
id: GO:0004641
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref266
type: RelationshipXref
id: GO:0003937
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref267
type: RelationshipXref
id: 4233955
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233955

RelationshipXref264
type: RelationshipXref
id: GO:0004643
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref265
type: RelationshipXref
id: 4233957
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233957

RelationshipXref268
type: RelationshipXref
id: GO:0003938
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref269
type: RelationshipXref
id: 4233948
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233948

UnificationXref209
type: UnificationXref
id: 4233608
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233608

UnificationXref201
type: UnificationXref
id: CHEBI:16108
db: ChEBI

UnificationXref202
type: UnificationXref
id: 75970
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=75970

UnificationXref203
type: UnificationXref
id: REACT_4977
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4977.2

UnificationXref204
type: UnificationXref
id: CHEBI:29052
db: ChEBI

UnificationXref205
type: UnificationXref
id: 29578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29578

UnificationXref206
type: UnificationXref
id: REACT_3912
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3912.2

UnificationXref207
type: UnificationXref
id: P66940
db: UniProt

UnificationXref208
type: UnificationXref
id: 4233607
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233607

http://identifiers.org/pubmed/7951672
type: PublicationXref
id: 7951672
author: Hale, DE
author: Stanley, CA
db: Pubmed
title: Genetic disorders of mitochondrial fatty acid oxidation.
source: Curr Opin Pediatr 6:476-81
year: 1994

UnificationXref211
type: UnificationXref
id: REACT_28815
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28815.10

UnificationXref210
type: UnificationXref
id: 4233610
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233610

UniProt:P65528
type: ProteinReference
xref: UnificationXref3384
organism: BioSource1

UniProt:P65526
type: ProteinReference
xref: UnificationXref4384
organism: BioSource1

UnificationXref200
type: UnificationXref
id: 4233624
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233624

Cobalt [ChEBI:3788]
type: SmallMoleculeReference
name: Cobalt
name: Co2+
xref: UnificationXref1813

UnificationXref227
type: UnificationXref
id: 30485
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30485

RelationshipXref290
type: RelationshipXref
id: 4233899
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233899

UnificationXref228
type: UnificationXref
id: REACT_3473
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3473.2

RelationshipXref291
type: RelationshipXref
id: GO:0004070
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref229
type: UnificationXref
id: CHEBI:15377
db: ChEBI

RelationshipXref292
type: RelationshipXref
id: 4233897
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233897

RelationshipXref293
type: RelationshipXref
id: GO:0004151
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref223
type: UnificationXref
id: 4233639
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233639

RelationshipXref294
type: RelationshipXref
id: 4233895
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233895

UnificationXref224
type: UnificationXref
id: 4233876
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233876

RelationshipXref295
type: RelationshipXref
id: GO:0004152
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref225
type: UnificationXref
id: REACT_158142
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158142.3

Glucuronidation
type: Pathway
data source: Provenance1
pathway component: REACT 33265.10
evidence: Evidence462
xref: UnificationXref3256
xref: UnificationXref3255
xref: RelationshipXref488
pathway order: PathwayStep459
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref296
type: RelationshipXref
id: 4233889
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233889

UnificationXref226
type: UnificationXref
id: CHEBI:17835
db: ChEBI

RelationshipXref298
type: RelationshipXref
id: 4233883
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233883

UnificationXref231
type: UnificationXref
id: REACT_3683
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3683.1

2,6-diaminohexanoic acid
type: SmallMoleculeReference
name: Lysine acid
name: L-Lysine [ChEBI:18019]
name: L-Lysine
xref: UnificationXref3353

RelationshipXref297
type: RelationshipXref
id: GO:0004588
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref230
type: UnificationXref
id: 29356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356

UnificationXref233
type: UnificationXref
id: 29492
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29492

RelationshipXref299
type: RelationshipXref
id: GO:0004590
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref232
type: UnificationXref
id: CHEBI:18021
db: ChEBI

Fumaric acid
type: SmallMoleculeReference
name: ChEBI:18012 Fumaric acid
name: Trans-butenedioic acid
xref: UnificationXref1791

Acetylbenzene
type: SmallMoleculeReference
name: Phenyl methyl ketone
name: Acetophenone [ChEBI:2403]
name: Methyl phenyl ketone
name: Acetophenone
name: 1-Phenylethanone
xref: UnificationXref5045

3-Oxohexanoyl-CoA [ChEBI:27648]
type: SmallMoleculeReference
name: 3-ketohexanoyl-CoA
name: 3-Oxohexanoyl-CoA
xref: UnificationXref912

UnificationXref218
type: UnificationXref
id: P65700
db: UniProt

UnificationXref219
type: UnificationXref
id: 4233638
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233638

UnificationXref216
type: UnificationXref
id: 29728
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29728

UnificationXref217
type: UnificationXref
id: REACT_3406
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3406.2

http://identifiers.org/pubmed/17555404
type: PublicationXref
id: 17555404
author: Alp, NJ
author: Schmidt, TS
db: Pubmed
title: Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
source: Clin Sci (Lond) 113:47-63
year: 2007

UnificationXref214
type: UnificationXref
id: REACT_3116
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3116.2

UnificationXref215
type: UnificationXref
id: CHEBI:17794
db: ChEBI

UnificationXref212
type: UnificationXref
id: CHEBI:16001
db: ChEBI

UnificationXref213
type: UnificationXref
id: 29800
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29800

UnificationXref222
type: UnificationXref
id: REACT_2525
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2525.2

UnificationXref221
type: UnificationXref
id: 29926
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29926

NADP+
type: SmallMoleculeReference
name: TPN
name: NADP+ [ChEBI:18009]
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref386

UnificationXref220
type: UnificationXref
id: CHEBI:18420
db: ChEBI

Pristanic acid
type: SmallMolecule
entity reference: CHEBI:51340
data source: Provenance1
xref: UnificationXref1123
xref: UnificationXref1124
cellular location: GO:0005782
comment: Reactome DB_ID: 389612

Mg++
type: SmallMolecule
entity reference: Mg++
data source: Provenance1
name: Magnesium
xref: UnificationXref1117
xref: UnificationXref1116
cellular location: GO:0005782
comment: Reactome DB_ID: 191328
display name: Mg2+

(2S) Pristanoyl-CoA
type: SmallMolecule
entity reference: (2S)-pristanoyl-CoA [ChEBI:64039]
data source: Provenance1
xref: UnificationXref1133
xref: UnificationXref1134
cellular location: GO:0005782
comment: Reactome DB_ID: 389893

http://identifiers.org/pubmed/9878398
type: PublicationXref
id: 9878398
author: Mirande, M
author: Siatecka, M
author: Robinson, JC
author: Berthonneau, E
author: Quevillon, S
db: Pubmed
title: Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein
source: J Mol Biol 285:183-95
year: 1999

UnificationXref1679
type: UnificationXref
id: REACT_118525
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118525.7

(2R) Pristanoyl-CoA
type: SmallMolecule
entity reference: CHEBI:51341
data source: Provenance1
xref: UnificationXref1127
xref: UnificationXref1126
cellular location: GO:0005782
comment: Reactome DB_ID: 389569

UnificationXref1678
type: UnificationXref
id: 4236279
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236279

propionyl CoA
type: SmallMolecule
entity reference: CHEBI:15539
data source: Provenance1
xref: UnificationXref1146
xref: UnificationXref1147
cellular location: GO:0005782
comment: Reactome DB_ID: 192314

UnificationXref1677
type: UnificationXref
id: REACT_81334
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81334.9

3-ketopristanoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15371
data source: Provenance1
xref: UnificationXref1143
xref: UnificationXref1144
cellular location: GO:0005782
comment: Reactome DB_ID: 389996

UnificationXref1676
type: UnificationXref
id: 4235116
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235116

UnificationXref250
type: UnificationXref
id: REACT_4060
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4060.2

http://identifiers.org/pubmed/2935202
type: PublicationXref
id: 2935202
author: Scott, J E
author: Haigh, M
db: Pubmed
title: 'Small'-proteoglycan:collagen interactions: keratan sulphate proteoglycan associates with rabbit corneal collagen fibrils at the 'a' and 'c' bands
source: Biosci. Rep. 5:765-74
year: 1985

UnificationXref1675
type: UnificationXref
id: REACT_19657
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19657.1

UnificationXref251
type: UnificationXref
id: CHEBI:30744
db: ChEBI

UnificationXref1674
type: UnificationXref
id: 428671
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428671

UnificationXref1673
type: UnificationXref
id: CHEBI:17585
db: ChEBI

UnificationXref1672
type: UnificationXref
id: REACT_19431
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19431.2

UnificationXref254
type: UnificationXref
id: 113581
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113581

http://identifiers.org/pubmed/15893380
type: PublicationXref
id: 15893380
author: Jackowski, S
author: Zhang, YM
author: Rock, CO
author: Leonardi, R
db: Pubmed
title: Coenzyme A: back in action
source: Prog Lipid Res 44:125-53
year: 2005

UnificationXref1671
type: UnificationXref
id: 428203
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428203

UnificationXref255
type: UnificationXref
id: REACT_4478
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4478.1

UnificationXref1670
type: UnificationXref
id: CHEBI:37550
db: ChEBI

UnificationXref252
type: UnificationXref
id: 113587
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113587

http://identifiers.org/pubmed/11500517
type: PublicationXref
id: 11500517
author: Su, HM
author: Moser, HW
author: Moser, AB
author: Watkins, PA
db: Pubmed
title: Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis
source: J Biol Chem 276:38115-20
year: 2001

UnificationXref253
type: UnificationXref
id: REACT_5253
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5253.2

UnificationXref248
type: UnificationXref
id: CHEBI:32816
db: ChEBI

UnificationXref247
type: UnificationXref
id: REACT_2572
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2572.1

UnificationXref246
type: UnificationXref
id: 29376
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29376

UnificationXref245
type: UnificationXref
id: CHEBI:16526
db: ChEBI

UnificationXref249
type: UnificationXref
id: 113557
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113557

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
type: Pathway
data source: Provenance1
pathway component: REACT 154109.3
evidence: Evidence698
xref: UnificationXref4626
xref: UnificationXref4625
xref: RelationshipXref630
pathway order: PathwayStep682
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

4,8,12-trimethyltridecanoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15495
data source: Provenance1
xref: UnificationXref1150
xref: UnificationXref1149
cellular location: GO:0005782
comment: Reactome DB_ID: 390002

H2O
type: SmallMolecule
entity reference: CHEBI:15377
data source: Provenance1
xref: UnificationXref1156
xref: UnificationXref1155
cellular location: GO:0005782
comment: Reactome DB_ID: 141343

Acetyl coenzyme A
type: SmallMolecule
entity reference: CHEBI:15351
data source: Provenance1
name: Acetyl-CoA
xref: UnificationXref1157
xref: UnificationXref1158
cellular location: GO:0005782
comment: Reactome DB_ID: 353123
display name: Ac-CoA

http://identifiers.org/pubmed/9083049
type: PublicationXref
id: 9083049
author: Lee, PT
author: Shepherd, JA
author: Tzagoloff, A
author: Myles, DC
author: Clarke, CF
author: Shtanko, A
author: Barkovich, RJ
db: Pubmed
title: Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis
source: J Biol Chem 272:9182-8
year: 1997

Acetate
type: SmallMolecule
entity reference: CHEBI:15366
data source: Provenance1
name: Ethanoic acid
name: Acetic acid
xref: UnificationXref1161
xref: UnificationXref1160
cellular location: GO:0005782
comment: Reactome DB_ID: 390305
display name: CH3COO-

Dihydroxyacetone phosphate
type: SmallMolecule
entity reference: Dihydroxyacetone phosphate
data source: Provenance1
name: Glycerone phosphate
xref: UnificationXref1184
xref: UnificationXref1183
cellular location: GO:0005782
comment: Reactome DB_ID: 390404
display name: DHAP

cerotyl-CoA
type: SmallMolecule
entity reference: CHEBI:52966
data source: Provenance1
name: Hexacosanoyl-CoA
xref: UnificationXref1174
xref: UnificationXref1175
cellular location: GO:0005782
comment: Reactome DB_ID: 390260
display name: C26:0 CoA

cerotyl-CoA
type: SmallMolecule
entity reference: CHEBI:52966
data source: Provenance1
name: Hexacosanoyl-CoA
xref: UnificationXref1172
xref: UnificationXref1173
cellular location: GO:0005829
comment: Reactome DB_ID: 390394
display name: C26:0 CoA

UnificationXref1667
type: UnificationXref
id: 4235114
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235114

hexadecan-1-ol
type: SmallMolecule
entity reference: Hexadecanol [ChEBI:5696]
data source: Provenance1
name: Hexadecanol
xref: UnificationXref1206
xref: UnificationXref1205
cellular location: GO:0005782
comment: Reactome DB_ID: 390440
display name: HXOL

UnificationXref1666
type: UnificationXref
id: O06249
db: UniProt

FAD
type: SmallMolecule
entity reference: FAD [ChEBI:16238]
data source: Provenance1
xref: UnificationXref1191
xref: UnificationXref1190
cellular location: GO:0005782
comment: Reactome DB_ID: 141335

UnificationXref1669
type: UnificationXref
id: REACT_29135
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29135.10

1-Palmitoyl dihydroxyacetone phosphate
type: SmallMolecule
entity reference: CHEBI:17868
data source: Provenance1
xref: UnificationXref1188
xref: UnificationXref1189
cellular location: GO:0005782
comment: Reactome DB_ID: 390419
display name: Palmitoylglycerone phosphate

UnificationXref1668
type: UnificationXref
id: 4235117
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235117

palmitoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15525
data source: Provenance1
xref: UnificationXref1186
xref: UnificationXref1185
cellular location: GO:0005782
comment: Reactome DB_ID: 390426
display name: PalmCoA

UnificationXref1663
type: UnificationXref
id: CHEBI:17600
db: ChEBI

MT3960
type: ProteinReference
name: sod
name: Rv3846
name: MTCY01A6.22c
name: UniProt:P17670 sodB
name: sodB
name: sodA
xref: UnificationXref4754
comment: FUNCTION Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.CATALYTIC ACTIVITY 2 superoxide + 2 H(+) = O(2) + H(2)O(2).COFACTOR Binds 1 iron ion per subunit.SUBUNIT Homotetramer.SIMILARITY Belongs to the iron/manganese superoxide dismutase family.CAUTION Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used.
organism: BioSource1

UnificationXref1662
type: UnificationXref
id: REACT_20211
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20211.2

UnificationXref1665
type: UnificationXref
id: REACT_20116
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20116.2

UnificationXref1664
type: UnificationXref
id: 428663
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428663

UnificationXref240
type: UnificationXref
id: 4236065
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236065

UnificationXref241
type: UnificationXref
id: REACT_31832
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31832.10

UnificationXref242
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

UnificationXref1661
type: UnificationXref
id: 428686
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428686

UnificationXref243
type: UnificationXref
id: 113593
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113593

UnificationXref1660
type: UnificationXref
id: CHEBI:17553
db: ChEBI

UnificationXref244
type: UnificationXref
id: REACT_3422
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3422.1

ChEBI:33723 [4Fe-4S](1+)
type: SmallMoleculeReference
name: [4Fe-4S](1+)
xref: UnificationXref5214

UnificationXref235
type: UnificationXref
id: P96377
db: UniProt

[4Fe-4S](2+)
type: SmallMoleculeReference
name: ChEBI:33722 [4Fe-4S](2+)
xref: UnificationXref2587

UnificationXref234
type: UnificationXref
id: REACT_5622
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5622.2

UnificationXref237
type: UnificationXref
id: 4233645
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233645

UnificationXref236
type: UnificationXref
id: 4233644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233644

UnificationXref239
type: UnificationXref
id: REACT_112925
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112925.8

UnificationXref238
type: UnificationXref
id: 4233870
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233870

http://identifiers.org/pubmed/21682741
type: PublicationXref
id: 21682741
author: Minnicozzi, M
author: Fenton, MJ
author: Sawyer, RT
db: Pubmed
title: Innate immunity in allergic disease
source: Immunol Rev 242:106-27
year: 2011

http://identifiers.org/pubmed/15520807
type: PublicationXref
id: 15520807
author: Wellbrock, C
author: Karasarides, M
author: Marais, R
db: Pubmed
title: The RAF proteins take centre stage
source: Nat Rev Mol Cell Biol 5:875-85
year: 2004

1-Hydroxytricarballylic acid
type: SmallMolecule
entity reference: D-threo-Isocitric acid
data source: Provenance1
name: 1-Hydroxypropane-1,2,3-tricarboxylic acid
name: D-erythro-Isocitric acid
name: D-threo-Isocitric acid
name: Isocitric acid
name: Isocitrate
name: (1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylate
xref: UnificationXref1218
xref: UnificationXref1217
cellular location: GO:0005782
comment: Reactome DB_ID: 389548
display name: ISCIT

Palmitic acid
type: SmallMolecule
entity reference: CHEBI:15756
data source: Provenance1
name: Palmitate
xref: UnificationXref1208
xref: UnificationXref1207
cellular location: GO:0005782
comment: Reactome DB_ID: 390435
display name: PALM

O-alkylglycerone phosphate
type: SmallMolecule
entity reference: CHEBI:17197
data source: Provenance1
name: O-hexadecylglycerone phosphate
name: O-hexadecyldihydroxyacetone phosphate
xref: UnificationXref1211
xref: UnificationXref1210
cellular location: GO:0005782
comment: Reactome DB_ID: 390409
display name: GO3P

UnificationXref1658
type: UnificationXref
id: 428275
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428275

(S)-2-methyl-3-oxopropanoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15466
data source: Provenance1
name: D-methylmalonyl-CoA
xref: UnificationXref979
xref: UnificationXref978
cellular location: GO:0005759
comment: Reactome DB_ID: 71019
display name: MEMA-CoA

UnificationXref1657
type: UnificationXref
id: CHEBI:16893
db: ChEBI

trans-dec-3-enoyl-CoA
type: SmallMolecule
entity reference: CHEBI:29126
data source: Provenance1
xref: UnificationXref964
xref: UnificationXref963
cellular location: GO:0005759
comment: Reactome DB_ID: 109994
display name: 3-trans-decenoyl-CoA

http://identifiers.org/pubmed/11248239
type: PublicationXref
id: 11248239
author: Gärtner, J
author: Mayerhofer, P
author: Roerig, P
author: Holzinger, A
db: Pubmed
title: Characterization and functional analysis of the nucleotide binding fold in human peroxisomal ATP binding cassette transporters
source: FEBS Lett 492:66-72
year: 2001

http://identifiers.org/pubmed/12009299
type: PublicationXref
id: 12009299
author: Wang, Z
author: Wang, Y
author: Huang, Y
author: Mao, Y
author: Xu, Y
author: Gu, X
author: Gu, S
author: Xie, Y
author: Li, Y
author: Ji, C
author: Ying, K
author: Deng, Y
db: Pubmed
title: NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties
source: Int J Biochem Cell Biol 34:1035-50
year: 2002

UnificationXref1656
type: UnificationXref
id: REACT_149329
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149329.4

adenosylcobalamin
type: SmallMolecule
entity reference: a-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme
data source: Provenance1
xref: UnificationXref990
xref: UnificationXref991
cellular location: GO:0005759
comment: Reactome DB_ID: 3159297
display name: AdoCbl

UnificationXref1655
type: UnificationXref
id: 4236118
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236118

(R)-2-methyl-3-oxopropanoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15465
data source: Provenance1
name: L-methylmalonyl-CoA
xref: UnificationXref982
xref: UnificationXref981
cellular location: GO:0005759
comment: Reactome DB_ID: 71009
display name: L-MM-CoA

UnificationXref1659
type: UnificationXref
id: REACT_19850
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19850.2

UnificationXref1650
type: UnificationXref
id: 4235811
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235811

UnificationXref276
type: UnificationXref
id: REACT_11975
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11975.2

UnificationXref277
type: UnificationXref
id: CHEBI:15846
db: ChEBI

UnificationXref274
type: UnificationXref
id: CHEBI:30797
db: ChEBI

UnificationXref275
type: UnificationXref
id: 198498
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=198498

UnificationXref1654
type: UnificationXref
id: REACT_159075
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159075.3

UnificationXref272
type: UnificationXref
id: 113559
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113559

UnificationXref1653
type: UnificationXref
id: 4236361
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236361

UnificationXref273
type: UnificationXref
id: REACT_3839
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3839.2

UnificationXref1652
type: UnificationXref
id: REACT_159390
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159390.3

UnificationXref270
type: UnificationXref
id: 4233654
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233654

UnificationXref1651
type: UnificationXref
id: 4235813
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235813

UnificationXref271
type: UnificationXref
id: CHEBI:15351
db: ChEBI

UnificationXref269
type: UnificationXref
id: REACT_81868
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81868.9

UnificationXref268
type: UnificationXref
id: 4233653
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233653

UnificationXref267
type: UnificationXref
id: 4233651
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233651

Glycerol-3-phosphate
type: SmallMolecule
entity reference: CHEBI:15978
data source: Provenance1
xref: UnificationXref1039
xref: UnificationXref1038
cellular location: GO:0005759
comment: Reactome DB_ID: 188458
display name: G3P

Dihydroxyacetone phosphate
type: SmallMolecule
entity reference: Dihydroxyacetone phosphate
data source: Provenance1
name: Glycerone phosphate
xref: UnificationXref1040
xref: UnificationXref1041
cellular location: GO:0005759
comment: Reactome DB_ID: 188451
display name: DHAP

Succinyl-CoA
type: SmallMolecule
entity reference: CHEBI:15380
data source: Provenance1
name: Succinyl coenzyme A
xref: UnificationXref998
xref: UnificationXref999
cellular location: GO:0005759
comment: Reactome DB_ID: 70958
display name: SUCC-CoA

acetoacetyl-CoA
type: SmallMolecule
entity reference: CHEBI:15345
data source: Provenance1
xref: UnificationXref1010
xref: UnificationXref1009
cellular location: GO:0005759
comment: Reactome DB_ID: 73871
display name: ACA-CoA

acetoacetate
type: SmallMolecule
entity reference: CHEBI:15344
data source: Provenance1
xref: UnificationXref1019
xref: UnificationXref1020
cellular location: GO:0005759
comment: Reactome DB_ID: 73909
display name: ACA

Norepinephrine Neurotransmitter Release Cycle
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction303
evidence: Evidence529
xref: UnificationXref3621
xref: UnificationXref3622
pathway order: PathwayStep521
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Ethylenesuccinic acid
type: SmallMolecule
entity reference: CHEBI:15741
data source: Provenance1
name: Butanedionic acid
name: Succinate
name: Succinic acid
xref: UnificationXref1022
xref: UnificationXref1023
cellular location: GO:0005759
comment: Reactome DB_ID: 113536
display name: SUCCA

UnificationXref1645
type: UnificationXref
id: O06266
db: UniProt

Pyrophosphate
type: SmallMolecule
entity reference: CHEBI:29888
data source: Provenance1
xref: UnificationXref1091
xref: UnificationXref1090
cellular location: GO:0005782
comment: Reactome DB_ID: 389593
display name: PPi

UnificationXref1644
type: UnificationXref
id: REACT_150571
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150571.1

adenosine 5'-monophosphate
type: SmallMolecule
entity reference: CHEBI:16027
data source: Provenance1
xref: UnificationXref1088
xref: UnificationXref1087
cellular location: GO:0005782
comment: Reactome DB_ID: 389620
display name: AMP

UnificationXref1647
type: UnificationXref
id: P95276
db: UniProt

phytanic acid
type: SmallMolecule
entity reference: Phytanate
data source: Provenance1
xref: UnificationXref1086
xref: UnificationXref1085
cellular location: GO:0005782
comment: Reactome DB_ID: 389596
display name: Phytanate

UnificationXref1646
type: UnificationXref
id: 4235806
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235806

CoA-SH
type: SmallMolecule
entity reference: CHEBI:15346
data source: Provenance1
xref: UnificationXref1083
xref: UnificationXref1082
cellular location: GO:0005782
comment: Reactome DB_ID: 193514

http://identifiers.org/pubmed/9251237
type: PublicationXref
id: 9251237
author: Gallagher, JT
author: Stringer, SE
db: Pubmed
title: Heparan sulphate
source: Int J Biochem Cell Biol 29:709-14
year: 1997

UnificationXref1649
type: UnificationXref
id: 4235810
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235810

ATP
type: SmallMolecule
entity reference: CHEBI:15422
data source: Provenance1
xref: UnificationXref1080
xref: UnificationXref1081
cellular location: GO:0005782
comment: Reactome DB_ID: 389573

UnificationXref1648
type: UnificationXref
id: 4235809
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235809

http://identifiers.org/pubmed/2667896
type: PublicationXref
id: 2667896
author: Hwang, PK
author: Newgard, CB
author: Fletterick, RJ
db: Pubmed
title: The family of glycogen phosphorylases: structure and function
source: Crit Rev Biochem Mol Biol 24:69-99
year: 1989

UnificationXref263
type: UnificationXref
id: REACT_3612
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3612.3

UnificationXref264
type: UnificationXref
id: CHEBI:18291
db: ChEBI

UnificationXref265
type: UnificationXref
id: 113527
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113527

UnificationXref266
type: UnificationXref
id: REACT_4600
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4600.2

http://identifiers.org/pubmed/22101253
type: PublicationXref
id: 22101253
author: Rouault, Tracey A
author: Kovtunovych, Gennadiy
author: Crooks, Daniel R
author: Shi, Yanbo
author: Ghosh, Manik
db: Pubmed
title: Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis
source: Biochim. Biophys. Acta 1823:484-92
year: 2012

UnificationXref1641
type: UnificationXref
id: 2142783
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142783

UnificationXref1640
type: UnificationXref
id: CHEBI:63966
db: ChEBI

UnificationXref260
type: UnificationXref
id: 4233650
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233650

UnificationXref1643
type: UnificationXref
id: 2161883
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161883

UnificationXref261
type: UnificationXref
id: CHEBI:15956
db: ChEBI

UnificationXref1642
type: UnificationXref
id: REACT_151386
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151386.1

UnificationXref262
type: UnificationXref
id: 29582
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29582

UnificationXref257
type: UnificationXref
id: 113548
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113548

UnificationXref256
type: UnificationXref
id: CHEBI:18367
db: ChEBI

UnificationXref259
type: UnificationXref
id: P95127
db: UniProt

UnificationXref258
type: UnificationXref
id: REACT_5781
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5781.2

Trafficking of dietary sterols
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction47
evidence: Evidence98
xref: UnificationXref611
xref: RelationshipXref87
xref: UnificationXref612
pathway order: PathwayStep95
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Thiamin diphosphate
type: SmallMolecule
entity reference: CHEBI:18290
data source: Provenance1
name: Thiamin pyrophosphate
xref: UnificationXref1113
xref: UnificationXref1112
cellular location: GO:0005782
comment: Reactome DB_ID: 389589
display name: TPP

Formyl-CoA
type: SmallMolecule
entity reference: CHEBI:15522
data source: Provenance1
xref: UnificationXref1107
xref: UnificationXref1106
cellular location: GO:0005782
comment: Reactome DB_ID: 389578
display name: FOR-CoA

http://identifiers.org/pubmed/19428801
type: PublicationXref
id: 19428801
author: Buddhala, C
author: Wu, Jer-Yuarn
author: Hsu, CC
db: Pubmed
title: A novel mechanism for GABA synthesis and packaging into synaptic vesicles
source: Neurochem Int 55:9-12
year: 2009

Pristanal
type: SmallMolecule
entity reference: CHEBI:49189
data source: Provenance1
xref: UnificationXref1110
xref: UnificationXref1109
cellular location: GO:0005782
comment: Reactome DB_ID: 389636

Phytanoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15538
data source: Provenance1
xref: UnificationXref1093
xref: UnificationXref1094
cellular location: GO:0005782
comment: Reactome DB_ID: 389615

2-Hydroxyphytanoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15475
data source: Provenance1
xref: UnificationXref1104
xref: UnificationXref1103
cellular location: GO:0005782
comment: Reactome DB_ID: 389594
display name: 3S2HPhy-CoA

UnificationXref295
type: UnificationXref
id: REACT_2875
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2875.1

UnificationXref294
type: UnificationXref
id: 29438
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438

UnificationXref293
type: UnificationXref
id: CHEBI:15996
db: ChEBI

UnificationXref292
type: UnificationXref
id: REACT_106078
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106078.9

CHEBI:71956
type: SmallMoleculeReference
name: CHEBI:71956 [ChEBI:71956]
xref: UnificationXref3500

UnificationXref299
type: UnificationXref
id: 29420
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29420

UnificationXref298
type: UnificationXref
id: CHEBI:17552
db: ChEBI

UnificationXref297
type: UnificationXref
id: REACT_2373
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2373.1

UnificationXref296
type: UnificationXref
id: 113528
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113528

UnificationXref291
type: UnificationXref
id: 4234704
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234704

UnificationXref290
type: UnificationXref
id: 4234702
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234702

Decanoyl-CoA
type: SmallMolecule
entity reference: Decanoyl-CoA
data source: Provenance1
xref: UnificationXref851
xref: UnificationXref850
cellular location: GO:0005759
comment: Reactome DB_ID: 77308
display name: DEC-CoA

trans-Dec-2-enoyl-CoA
type: SmallMolecule
entity reference: trans-Dec-2-enoyl-CoA
data source: Provenance1
xref: UnificationXref857
xref: UnificationXref858
cellular location: GO:0005759
comment: Reactome DB_ID: 77343

3-Oxodecanoyl-CoA
type: SmallMolecule
entity reference: 3-Oxodecanoyl-CoA [ChEBI:28528]
data source: Provenance1
xref: UnificationXref871
xref: UnificationXref870
cellular location: GO:0005759
comment: Reactome DB_ID: 77339

(S)-Hydroxydecanoyl-CoA
type: SmallMolecule
entity reference: (S)-Hydroxydecanoyl-CoA
data source: Provenance1
xref: UnificationXref865
xref: UnificationXref866
cellular location: GO:0005759
comment: Reactome DB_ID: 77341

trans-Oct-2-enoyl-CoA
type: SmallMolecule
entity reference: trans-Oct-2-enoyl-CoA [ChEBI:27537]
data source: Provenance1
xref: UnificationXref880
xref: UnificationXref881
cellular location: GO:0005759
comment: Reactome DB_ID: 77332

Octanoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15533
data source: Provenance1
xref: UnificationXref874
xref: UnificationXref873
cellular location: GO:0005759
comment: Reactome DB_ID: 77337

3-Oxooctanoyl-CoA
type: SmallMolecule
entity reference: CHEBI:28264
data source: Provenance1
xref: UnificationXref890
xref: UnificationXref891
cellular location: GO:0005759
comment: Reactome DB_ID: 77328

Synthesis of UDP-N-acetyl-glucosamine
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction3
evidence: Evidence18
xref: UnificationXref74
xref: UnificationXref73
xref: RelationshipXref11
pathway order: PathwayStep16
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

(S)-Hydroxyoctanoyl-CoA
type: SmallMolecule
entity reference: (S)-3-Hydroxyoctanoyl-CoA
data source: Provenance1
xref: UnificationXref885
xref: UnificationXref886
cellular location: GO:0005759
comment: Reactome DB_ID: 77330

trans-Hex-2-enoyl-CoA
type: SmallMolecule
entity reference: trans-Hex-2-enoyl-CoA [ChEBI:28706]
data source: Provenance1
xref: UnificationXref901
xref: UnificationXref900
cellular location: GO:0005759
comment: Reactome DB_ID: 77324

Hexanoyl-CoA
type: SmallMolecule
entity reference: Hexanoyl-CoA
data source: Provenance1
xref: UnificationXref893
xref: UnificationXref894
cellular location: GO:0005759
comment: Reactome DB_ID: 77326
display name: HX-CoA

UnificationXref289
type: UnificationXref
id: 4234701
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234701

UnificationXref282
type: UnificationXref
id: CHEBI:16908
db: ChEBI

UnificationXref281
type: UnificationXref
id: REACT_5376
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5376.2

UnificationXref284
type: UnificationXref
id: REACT_5115
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5115.1

UnificationXref283
type: UnificationXref
id: 73473
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73473

UnificationXref286
type: UnificationXref
id: 70106
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106

UnificationXref285
type: UnificationXref
id: CHEBI:15378
db: ChEBI

UnificationXref288
type: UnificationXref
id: P0A5J6
db: UniProt

UnificationXref287
type: UnificationXref
id: REACT_4941
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4941.2

3-Oxohexanoyl-CoA
type: SmallMolecule
entity reference: 3-Oxohexanoyl-CoA [ChEBI:27648]
data source: Provenance1
xref: UnificationXref914
xref: UnificationXref913
cellular location: GO:0005759
comment: Reactome DB_ID: 77320

Butanoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15517
data source: Provenance1
name: beta-hydroxybutyryl-CoA
xref: UnificationXref916
xref: UnificationXref917
cellular location: GO:0005759
comment: Reactome DB_ID: 77318
display name: BT-CoA

UnificationXref280
type: UnificationXref
id: 76213
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76213

http://identifiers.org/pubmed/14990571
type: PublicationXref
id: 14990571
author: Sherratt, MJ
author: Shuttleworth, CA
author: Stephan, S
author: Hodson, N
author: Kielty, CM
db: Pubmed
title: Expression and supramolecular assembly of recombinant alpha1(viii) and alpha2(viii) collagen homotrimers
source: J Biol Chem 279:21469-77
year: 2004

(S)-Hydroxyhexanoyl-CoA
type: SmallMolecule
entity reference: CHEBI:28276
data source: Provenance1
xref: UnificationXref909
xref: UnificationXref908
cellular location: GO:0005759
comment: Reactome DB_ID: 77322

cis,cis-3,6-Dodecadienoyl-CoA
type: SmallMolecule
entity reference: CHEBI:28002
data source: Provenance1
xref: UnificationXref941
xref: UnificationXref940
cellular location: GO:0005759
comment: Reactome DB_ID: 77358

linoleoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15530
data source: Provenance1
xref: UnificationXref937
xref: UnificationXref938
cellular location: GO:0005759
comment: Reactome DB_ID: 77359
display name: LIN-CoA

(S)-3-Hydroxybutanoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15453
data source: Provenance1
xref: UnificationXref928
xref: UnificationXref929
cellular location: GO:0005759
comment: Reactome DB_ID: 77251
display name: 3HB-CoA

Crotonoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15473
data source: Provenance1
xref: UnificationXref923
xref: UnificationXref924
cellular location: GO:0005759
comment: Reactome DB_ID: 77313

(2-trans,4-cis)-deca-2,4-dienoyl-CoA
type: SmallMolecule
entity reference: CHEBI:29119
data source: Provenance1
xref: UnificationXref958
xref: UnificationXref959
cellular location: GO:0005759
comment: Reactome DB_ID: 109990
display name: 2-trans-4-cis-decadienoyl-CoA

cis-dec-4-enoyl-CoA
type: SmallMolecule
entity reference: CHEBI:29140
data source: Provenance1
xref: UnificationXref954
xref: UnificationXref953
cellular location: GO:0005759
comment: Reactome DB_ID: 109986
display name: 4-cis-decenoyl-CoA

trans,cis-Lauro-2,6-dienoyl-CoA
type: SmallMolecule
entity reference: trans,cis-Lauro-2,6-dienoyl-CoA
data source: Provenance1
xref: UnificationXref945
xref: UnificationXref946
cellular location: GO:0005759
comment: Reactome DB_ID: 77360

UnificationXref278
type: UnificationXref
id: 29360
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29360

UnificationXref279
type: UnificationXref
id: REACT_5381
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5381.1

UnificationXref1693
type: UnificationXref
id: 4236332
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236332

UnificationXref1694
type: UnificationXref
id: REACT_137715
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137715.5

UnificationXref1691
type: UnificationXref
id: 4235558
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235558

UnificationXref1692
type: UnificationXref
id: REACT_146573
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146573.5

UnificationXref1697
type: UnificationXref
id: CHEBI:17407
db: ChEBI

UnificationXref1698
type: UnificationXref
id: 2162257
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162257

UnificationXref1695
type: UnificationXref
id: 4236280
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236280

UnificationXref1696
type: UnificationXref
id: REACT_32725
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32725.10

UnificationXref1699
type: UnificationXref
id: REACT_161071
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161071.1

Water
type: SmallMolecule
entity reference: CHEBI:15377
data source: Provenance1
xref: UnificationXref777
xref: UnificationXref776
cellular location: GO:0005759
comment: Reactome DB_ID: 113521
display name: H2O

trans-Hexadec-2-enoyl-CoA
type: SmallMolecule
entity reference: trans-Hexadec-2-enoyl-CoA
data source: Provenance1
xref: UnificationXref771
xref: UnificationXref772
cellular location: GO:0005759
comment: Reactome DB_ID: 77284

DPN
type: SmallMolecule
entity reference: CHEBI:15846
data source: Provenance1
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref788
xref: UnificationXref789
cellular location: GO:0005759
comment: Reactome DB_ID: 113526
display name: NAD

(S)-3-Hydroxyhexadecanoyl-CoA
type: SmallMolecule
entity reference: (S)-3-Hydroxyhexadecanoyl-CoA [ChEBI:27402]
data source: Provenance1
xref: UnificationXref780
xref: UnificationXref779
cellular location: GO:0005759
comment: Reactome DB_ID: 77300

Flavin adenine dinucleotide
type: SmallMolecule
entity reference: FAD [ChEBI:16238]
data source: Provenance1
xref: UnificationXref763
xref: UnificationXref762
cellular location: GO:0005759
comment: Reactome DB_ID: 113596
display name: FAD

Phosphatidic acid
type: SmallMolecule
entity reference: CHEBI:16337
data source: Provenance1
xref: UnificationXref752
xref: UnificationXref751
cellular location: GO:0005789
comment: Reactome DB_ID: 426755
display name: PA

FADH2
type: SmallMolecule
entity reference: CHEBI:17877
data source: Provenance1
xref: UnificationXref768
xref: UnificationXref769
cellular location: GO:0005759
comment: Reactome DB_ID: 31649

palmitoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15525
data source: Provenance1
xref: UnificationXref766
xref: UnificationXref765
cellular location: GO:0005759
comment: Reactome DB_ID: 77281
display name: PalmCoA

http://identifiers.org/pubmed/21755941
type: PublicationXref
id: 21755941
author: Sofia, MJ
author: Murakami, E
author: Bao, H
author: Furman, PA
author: Du, J
author: Mosley, RT
db: Pubmed
title: Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates
source: J Med Chem 54:5902-14
year: 2011

UnificationXref1690
type: UnificationXref
id: 4235556
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235556

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Provenance1
xref: UnificationXref793
xref: UnificationXref794
cellular location: GO:0005759
comment: Reactome DB_ID: 113529

3-Oxopalmitoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15491
data source: Provenance1
xref: UnificationXref792
xref: UnificationXref791
cellular location: GO:0005759
comment: Reactome DB_ID: 77302

UnificationXref1680
type: UnificationXref
id: CHEBI:17761
db: ChEBI

UnificationXref1681
type: UnificationXref
id: 429807
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429807

UnificationXref1682
type: UnificationXref
id: REACT_20143
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20143.2

UnificationXref1683
type: UnificationXref
id: CHEBI:33575
db: ChEBI

UnificationXref1684
type: UnificationXref
id: 1861754
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1861754

UnificationXref1685
type: UnificationXref
id: REACT_117795
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117795.1

UnificationXref1686
type: UnificationXref
id: CHEBI:16393
db: ChEBI

UnificationXref1687
type: UnificationXref
id: 1606609
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1606609

UnificationXref1688
type: UnificationXref
id: REACT_117060
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117060.2

UnificationXref1689
type: UnificationXref
id: O06769
db: UniProt

NADH
type: SmallMolecule
entity reference: CHEBI:16908
data source: Provenance1
xref: UnificationXref795
xref: UnificationXref796
cellular location: GO:0005759
comment: Reactome DB_ID: 29362

di-retinoid-pyridinium-ethanolamine
type: SmallMoleculeReference
name: di-retinoid-pyridinium-ethanolamine [ChEBI:71980]
name: A2E
xref: UnificationXref3550

(S)-3-Hydroxydodecanoyl-CoA
type: SmallMolecule
entity reference: (S)-3-Hydroxydodecanoyl-CoA [ChEBI:27668]
data source: Provenance1
xref: UnificationXref839
xref: UnificationXref840
cellular location: GO:0005759
comment: Reactome DB_ID: 77252

2-trans-Dodecenoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15471
data source: Provenance1
xref: UnificationXref834
xref: UnificationXref835
cellular location: GO:0005759
comment: Reactome DB_ID: 77255

Lauroyl-CoA
type: SmallMolecule
entity reference: CHEBI:15521
data source: Provenance1
xref: UnificationXref828
xref: UnificationXref827
cellular location: GO:0005759
comment: Reactome DB_ID: 77261
display name: LAU-CoA

3-Oxotetradecanoyl-CoA
type: SmallMolecule
entity reference: ChEBI:28726 3-oxotetradecanoyl-CoA
data source: Provenance1
xref: UnificationXref823
xref: UnificationXref822
cellular location: GO:0005759
comment: Reactome DB_ID: 77269

Ubiquinol biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction146
pathway component: BiochemicalReaction145
evidence: Evidence257
xref: UnificationXref1738
xref: RelationshipXref232
xref: UnificationXref1737
pathway order: PathwayStep254
pathway order: PathwayStep253
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

(S)-3-Hydroxytetradecanoyl-CoA
type: SmallMolecule
entity reference: (S)-3-Hydroxytetradecanoyl-CoA
data source: Provenance1
xref: UnificationXref818
xref: UnificationXref817
cellular location: GO:0005759
comment: Reactome DB_ID: 77276

trans-Tetradec-2-enoyl-CoA
type: SmallMolecule
entity reference: trans-Tetradec-2-enoyl-CoA
data source: Provenance1
xref: UnificationXref809
xref: UnificationXref810
cellular location: GO:0005759
comment: Reactome DB_ID: 77273

myristoyl-CoA
type: SmallMolecule
entity reference: CHEBI:15532
data source: Provenance1
xref: UnificationXref802
xref: UnificationXref803
cellular location: GO:0005759
comment: Reactome DB_ID: 77272
display name: MYS-CoA

Coenzyme A
type: SmallMolecule
entity reference: CHEBI:15346
data source: Provenance1
name: CoA-SH
xref: UnificationXref799
xref: UnificationXref800
cellular location: GO:0005759
comment: Reactome DB_ID: 29374
display name: CoA

3-Oxododecanoyl-CoA
type: SmallMolecule
entity reference: 3-Oxododecanoyl-CoA
data source: Provenance1
xref: UnificationXref848
xref: UnificationXref847
cellular location: GO:0005759
comment: Reactome DB_ID: 77253

UnificationXref1848
type: UnificationXref
id: 4233981
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233981

UnificationXref1849
type: UnificationXref
id: 4233982
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233982

RelationshipXref629
type: RelationshipXref
id: GO:0002474
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1846
type: UnificationXref
id: REACT_5071
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5071.2

RelationshipXref628
type: RelationshipXref
id: 4235411
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235411

UnificationXref1847
type: UnificationXref
id: P65829
db: UniProt

RelationshipXref627
type: RelationshipXref
id: GO:0004175
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1844
type: UnificationXref
id: CHEBI:17909
db: ChEBI

RelationshipXref626
type: RelationshipXref
id: GO:0000209
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1845
type: UnificationXref
id: 111284
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111284

RelationshipXref625
type: RelationshipXref
id: 4235416
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235416

UnificationXref1842
type: UnificationXref
id: 71067
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71067

RelationshipXref624
type: RelationshipXref
id: GO:0004177
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1843
type: UnificationXref
id: REACT_3428
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3428.2

RelationshipXref623
type: RelationshipXref
id: 4236019
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236019

UnificationXref1840
type: UnificationXref
id: REACT_112483
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112483.8

RelationshipXref622
type: RelationshipXref
id: GO:0034220
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1841
type: UnificationXref
id: CHEBI:18248
db: ChEBI

RelationshipXref621
type: RelationshipXref
id: 4235311
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235311

RelationshipXref620
type: RelationshipXref
id: GO:0043682
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1839
type: UnificationXref
id: 4236074
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236074

RelationshipXref618
type: RelationshipXref
id: GO:0004008
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1857
type: UnificationXref
id: 4233988
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233988

RelationshipXref617
type: RelationshipXref
id: GO:0015909
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1858
type: UnificationXref
id: 4233989
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233989

UnificationXref1859
type: UnificationXref
id: CHEBI:17345
db: ChEBI

Uroporphyrinogen I
type: SmallMoleculeReference
name: Uroporphyrinogen I [ChEBI:9904]
xref: UnificationXref3076

RelationshipXref619
type: RelationshipXref
id: 4235305
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235305

RelationshipXref614
type: RelationshipXref
id: 4235126
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235126

UnificationXref1853
type: UnificationXref
id: 4233990
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233990

RelationshipXref613
type: RelationshipXref
id: GO:0005366
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1854
type: UnificationXref
id: CHEBI:17202
db: ChEBI

RelationshipXref616
type: RelationshipXref
id: 4235239
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235239

UnificationXref1855
type: UnificationXref
id: 29602
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29602

RelationshipXref615
type: RelationshipXref
id: GO:0015245
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1856
type: UnificationXref
id: REACT_2342
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2342.1

RelationshipXref610
type: RelationshipXref
id: GO:0006811
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1850
type: UnificationXref
id: 4233984
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233984

http://identifiers.org/pubmed/19675644
type: PublicationXref
id: 19675644
author: Ribbe, MW
author: Mendel, RR
author: Schwarz, G
db: Pubmed
title: Molybdenum cofactors, enzymes and pathways
source: Nature 460:839-47
year: 2009

RelationshipXref612
type: RelationshipXref
id: 4235123
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235123

UnificationXref1851
type: UnificationXref
id: 4233987
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233987

http://identifiers.org/pubmed/19675643
type: PublicationXref
id: 19675643
author: Lill, R
db: Pubmed
title: Function and biogenesis of iron-sulphur proteins
source: Nature 460:831-8
year: 2009

RelationshipXref611
type: RelationshipXref
id: GO:0055056
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1852
type: UnificationXref
id: REACT_101205
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101205.9

http://identifiers.org/pubmed/10212249
type: PublicationXref
id: 10212249
author: Sondermann, P
author: Steegborn, C
author: Wahl, MC
author: Huber, R
author: Marinkovic, S
author: Jacob, U
author: Worbs, M
author: Clausen, T
db: Pubmed
title: Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration
source: J Biol Chem 274:12675-84
year: 1999

RelationshipXref649
type: RelationshipXref
id: 1222715
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222715

UnificationXref1866
type: UnificationXref
id: 111292
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111292

RelationshipXref648
type: RelationshipXref
id: 1222303
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222303

UnificationXref1867
type: UnificationXref
id: REACT_4144
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4144.2

RelationshipXref647
type: RelationshipXref
id: GO:0004784
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1864
type: UnificationXref
id: 4233986
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233986

RelationshipXref646
type: RelationshipXref
id: 1222636
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222636

UnificationXref1865
type: UnificationXref
id: CHEBI:17284
db: ChEBI

http://identifiers.org/pubmed/19244110
type: PublicationXref
id: 19244110
author: Vikis, HG
author: You, M
author: Lu, Y
author: Liu, Y
author: James, MA
db: Pubmed
title: RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway
source: Cancer Res 69:2108-16
year: 2009

UnificationXref1868
type: UnificationXref
id: 4233991
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233991

UnificationXref1869
type: UnificationXref
id: REACT_90579
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90579.9

RelationshipXref641
type: RelationshipXref
id: 1222305
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222305

RelationshipXref640
type: RelationshipXref
id: GO:0008113
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref645
type: RelationshipXref
id: GO:0015450
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1862
type: UnificationXref
id: 4233985
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233985

RelationshipXref644
type: RelationshipXref
id: GO:0052060
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1863
type: UnificationXref
id: REACT_95823
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95823.9

RelationshipXref643
type: RelationshipXref
id: 1222289
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222289

UnificationXref1860
type: UnificationXref
id: 113578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113578

RelationshipXref642
type: RelationshipXref
id: GO:0003840
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1861
type: UnificationXref
id: REACT_2761
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2761.1

UniProt:P63873 cysM
type: ProteinReference
name: MT1377
name: Rv1336
name: MTCY130.21
name: cysM
xref: UnificationXref5273
comment: FUNCTION Catalyzes the formation of a covalent CysO-cysteine adduct via a sulfur transfer, using the thiocarboxylated sulfur carrier protein CysO-COSH as sulfur donor and O-phospho-L-serine (OPS) as sulfur acceptor. Can also use sodium sulfide as sulfur donor in vitro, albeit with less efficiency, but not thiosulfate or thio-nitro-benzoate. O-acetylserine (OAS) is a very poor substrate in comparison with OPS. May be of particular importance for cysteine biosynthesis in the persistent phase of M.tuberculosis.CATALYTIC ACTIVITY O-phospho-L-serine + H(2)S = L-cysteine + phosphate.CATALYTIC ACTIVITY O-phospho-L-serine + [CysO]-SH = [CysO]-L-cysteine + phosphate.COFACTOR Pyridoxal phosphate.PATHWAY Amino-acid biosynthesis; L-cysteine biosynthesis.SUBUNIT Homodimer.INDUCTION Up-regulated under oxidative stress conditions.DOMAIN The five C-terminal amino acid residues are inserted into the active site cleft in the closed conformation, protect the aminoacrylate intermediate and are involved in sulfur donor selectivity.DISRUPTION PHENOTYPE Strains lacking this gene are shown to be attenuated in macrophages.SIMILARITY Belongs to the cysteine synthase/cystathionine beta-synthase family.
organism: BioSource1

RelationshipXref636
type: RelationshipXref
id: 1500775
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500775

UnificationXref1875
type: UnificationXref
id: CHEBI:18349
db: ChEBI

RelationshipXref635
type: RelationshipXref
id: 1222367
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222367

UnificationXref1876
type: UnificationXref
id: 111338
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111338

RelationshipXref638
type: RelationshipXref
id: GO:0016620
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1877
type: UnificationXref
id: REACT_5626
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5626.2

RelationshipXref637
type: RelationshipXref
id: 1222606
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222606

UnificationXref1878
type: UnificationXref
id: O53823
db: UniProt

UnificationXref1879
type: UnificationXref
id: 4233967
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233967

RelationshipXref639
type: RelationshipXref
id: 1222575
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222575

http://identifiers.org/pubmed/12807887
type: PublicationXref
id: 12807887
author: Morgan, A
author: Bernard, SE
author: Shuttleworth, CA
author: Humphries, J
author: Lomas, A
author: Bax, DV
author: Kielty, CM
author: Humphries, MJ
db: Pubmed
title: Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins
source: J Biol Chem 278:34605-16
year: 2003

RelationshipXref630
type: RelationshipXref
id: GO:0035872
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1870
type: UnificationXref
id: 4233992
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233992

RelationshipXref632
type: RelationshipXref
id: GO:0008941
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1871
type: UnificationXref
id: 4233993
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233993

RelationshipXref631
type: RelationshipXref
id: GO:0045087
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1872
type: UnificationXref
id: CHEBI:15428
db: ChEBI

RelationshipXref634
type: RelationshipXref
id: GO:0051920
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1873
type: UnificationXref
id: 29424
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29424

Chorismate via Shikimate Pathway
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction452
pathway component: BiochemicalReaction457
pathway component: BiochemicalReaction454
pathway component: BiochemicalReaction455
pathway component: BiochemicalReaction456
pathway component: BiochemicalReaction453
pathway component: BiochemicalReaction458
xref: UnificationXref5377
xref: RelationshipXref754
xref: UnificationXref5378
xref: http://identifiers.org/pubmed/15012217
pathway order: PathwayStep786
pathway order: PathwayStep792
pathway order: PathwayStep791
pathway order: PathwayStep789
pathway order: PathwayStep788
pathway order: PathwayStep787
pathway order: PathwayStep790
comment: Authored: Stephan, R, 2010-09-13
comment: The shikimate pathway leads to the biosynthesis of chorismate, which, in mycobacteria, is a precursor of aromatic amino acids, naphthoquinones, menaquinones and siderophores. The enzymes of this pathway are attractive pharmaceutical targets, as the pathway is absent from mammals, and there are no redundancies in it (Herrmann and Weaver, 1999).
comment: Edited: Jassal, B, 2011-02-16
comment: Reviewed: Warner, D, 2010-11-25
organism: BioSource1

Gap-filling DNA repair synthesis and ligation in GG-NER
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction364
evidence: Evidence649
xref: RelationshipXref590
xref: UnificationXref4320
xref: UnificationXref4319
pathway order: PathwayStep635
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref633
type: RelationshipXref
id: 1222307
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222307

UnificationXref1874
type: UnificationXref
id: REACT_5814
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5814.4

http://identifiers.org/pubmed/12887053
type: PublicationXref
id: 12887053
author: Maskos, K
author: Bode, W
db: Pubmed
title: Structural basis of the matrix metalloproteinases and their physiological inhibitors, the tissue inhibitors of metalloproteinases
source: Biol Chem 384:863-72
year: 2003

UnificationXref1805
type: UnificationXref
id: CHEBI:32796
db: ChEBI

UnificationXref1804
type: UnificationXref
id: REACT_98794
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98794.9

http://identifiers.org/pubmed/19283672
type: PublicationXref
id: 19283672
author: Mäki, Joni M
db: Pubmed
title: Lysyl oxidases in mammalian development and certain pathological conditions
source: Histol. Histopathol. 24:651-60
year: 2009

UnificationXref1803
type: UnificationXref
id: 4236072
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236072

UnificationXref1802
type: UnificationXref
id: REACT_136902
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136902.5

UnificationXref1801
type: UnificationXref
id: 4235151
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235151

UnificationXref1800
type: UnificationXref
id: REACT_90400
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90400.9

UnificationXref1814
type: UnificationXref
id: 880069
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=880069

cyclopropylamine
type: SmallMoleculeReference
name: cyclopropylamine [ChEBI:34660]
name: Aminocyclopropane
xref: UnificationXref3410

UnificationXref1813
type: UnificationXref
id: CHEBI:27638
db: ChEBI

UnificationXref1816
type: UnificationXref
id: 4235246
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235246

UnificationXref1815
type: UnificationXref
id: REACT_26586
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26586.1

UnificationXref1810
type: UnificationXref
id: 4235245
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235245

UnificationXref1812
type: UnificationXref
id: 4235247
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235247

UnificationXref1811
type: UnificationXref
id: REACT_140943
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140943.5

UnificationXref1806
type: UnificationXref
id: 879997
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879997

http://identifiers.org/pubmed/15115769
type: PublicationXref
id: 15115769
author: Shimonishi, M
author: Imai, Y
author: Hatae, T
author: Wada, M
author: Nakamura, M
author: Tanabe, T
author: Ullrich, V
author: Yokoyama, C
db: Pubmed
title: Purification and characterization of recombinant human prostacyclin synthase
source: J Biochem 135:455-63
year: 2004

UnificationXref1807
type: UnificationXref
id: REACT_25542
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25542.2

UnificationXref1808
type: UnificationXref
id: O07406
db: UniProt

UnificationXref1809
type: UnificationXref
id: 4235243
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235243

http://identifiers.org/pubmed/21494619
type: PublicationXref
id: 21494619
author: Gupta, RK
author: Tyagi, AK
author: Sauter, NK
author: Nangpal, P
author: Gupta, V
author: Khare, G
db: Pubmed
title: Ferritin structure from Mycobacterium tuberculosis: comparative study with homologues identifies extended C-terminus involved in ferroxidase activity
source: PLoS One 6:e18570
year: 2011

http://identifiers.org/pubmed/12040175
type: PublicationXref
id: 12040175
author: Iyengar, R
author: Ram, PT
author: Neves, SR
db: Pubmed
title: G protein pathways
source: Science 296:1636-9
year: 2002

RelationshipXref600
type: RelationshipXref
id: 4235070
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235070

RelationshipXref601
type: RelationshipXref
id: 4235062
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235062

5-Hydroxytryptamine
type: SmallMoleculeReference
name: 3-(2-Aminoethyl)-1H-indol-5-ol
name: Enteramine
name: 3-(2-Aminoethyl)-1H-indol-5-ol [ChEBI:28790]
name: Serotonin
xref: UnificationXref3208

RelationshipXref604
type: RelationshipXref
id: GO:0005452
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1823
type: UnificationXref
id: 4236073
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236073

RelationshipXref605
type: RelationshipXref
id: 4235109
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235109

UnificationXref1822
type: UnificationXref
id: REACT_147547
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147547.5

RelationshipXref602
type: RelationshipXref
id: 4235075
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235075

UnificationXref1821
type: UnificationXref
id: 4236307
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236307

RelationshipXref603
type: RelationshipXref
id: 4235059
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235059

UnificationXref1820
type: UnificationXref
id: 4235248
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235248

RelationshipXref608
type: RelationshipXref
id: GO:0015321
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1827
type: UnificationXref
id: O53275
db: UniProt

RelationshipXref609
type: RelationshipXref
id: 4235103
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235103

UnificationXref1826
type: UnificationXref
id: 4234481
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234481

RelationshipXref606
type: RelationshipXref
id: GO:0005254
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1825
type: UnificationXref
id: P64097
db: UniProt

RelationshipXref607
type: RelationshipXref
id: 4235090
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235090

UnificationXref1824
type: UnificationXref
id: REACT_99039
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99039.9

UnificationXref1819
type: UnificationXref
id: REACT_25934
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25934.1

UnificationXref1817
type: UnificationXref
id: CHEBI:29105
db: ChEBI

UnificationXref1818
type: UnificationXref
id: 880067
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=880067

UnificationXref1830
type: UnificationXref
id: REACT_6438
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_6438.3

UnificationXref1832
type: UnificationXref
id: 4234483
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234483

UnificationXref1831
type: UnificationXref
id: 4234482
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234482

UnificationXref1834
type: UnificationXref
id: REACT_99683
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99683.9

UnificationXref1833
type: UnificationXref
id: 4234485
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234485

UnificationXref1836
type: UnificationXref
id: REACT_93647
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93647.9

UnificationXref1835
type: UnificationXref
id: 4236193
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236193

UnificationXref1838
type: UnificationXref
id: REACT_93495
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93495.9

UnificationXref1837
type: UnificationXref
id: 4236194
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236194

UnificationXref1828
type: UnificationXref
id: 4234478
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234478

UnificationXref1829
type: UnificationXref
id: 159448
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159448

http://identifiers.org/pubmed/7350913
type: PublicationXref
id: 7350913
author: Lombardo, D
author: Guy, O
db: Pubmed
title: Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. II. Action on cholesterol esters and lipid-soluble vitamin esters.
source: Biochim Biophys Acta 611:147-55
year: 1980

http://identifiers.org/pubmed/7350912
type: PublicationXref
id: 7350912
author: Lombardo, D
author: Fauvel, J
author: Guy, O
db: Pubmed
title: Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. I. Action on carboxyl esters, glycerides and phospholipids.
source: Biochim Biophys Acta 611:136-46
year: 1980

RelationshipXref691
type: RelationshipXref
id: GO:0016810
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref500
type: UnificationXref
id: 4236339
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236339

RelationshipXref692
type: RelationshipXref
id: 879287
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879287

UnificationXref501
type: UnificationXref
id: REACT_143523
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143523.5

RelationshipXref690
type: RelationshipXref
id: 879254
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879254

UnificationXref504
type: UnificationXref
id: 4236059
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236059

UnificationXref505
type: UnificationXref
id: REACT_103806
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103806.9

UnificationXref502
type: UnificationXref
id: 4236264
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236264

UnificationXref503
type: UnificationXref
id: REACT_134911
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134911.5

UnificationXref508
type: UnificationXref
id: REACT_152225
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152225.1

UnificationXref509
type: UnificationXref
id: CHEBI:17268
db: ChEBI

UnificationXref506
type: UnificationXref
id: CHEBI:18384
db: ChEBI

UnificationXref507
type: UnificationXref
id: 1629753
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629753

http://identifiers.org/pubmed/14504269
type: PublicationXref
id: 14504269
author: Gerard, R
author: Li, WP
author: Tuma, PL
author: Yu, L
author: Cohen, JC
author: Graf, GA
author: Hobbs, HH
db: Pubmed
title: ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion
source: J Biol Chem 278:48275-82
year: 2003

RelationshipXref699
type: RelationshipXref
id: GO:0010127
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref698
type: RelationshipXref
id: 879242
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879242

RelationshipXref697
type: RelationshipXref
id: GO:0050607
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref696
type: RelationshipXref
id: GO:0010126
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref695
type: RelationshipXref
id: 879240
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879240

RelationshipXref694
type: RelationshipXref
id: GO:0016811
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref693
type: RelationshipXref
id: GO:0010125
db: GENE ONTOLOGY
relationship type: MI:0359

tRNA Aminoacylation
type: Pathway
data source: Provenance1
pathway component: REACT 86341.9
pathway component: REACT 77785.9
evidence: Evidence580
xref: UnificationXref3923
xref: RelationshipXref540
xref: UnificationXref3924
pathway order: PathwayStep556
pathway order: PathwayStep569
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/15172035
type: PublicationXref
id: 15172035
author: Kozel, BA
author: Ciliberto, CH
author: Mecham, RP
db: Pubmed
title: Deposition of tropoelastin into the extracellular matrix requires a competent elastic fiber scaffold but not live cells
source: Matrix Biol 23:23-34
year: 2004

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction109
pathway component: BiochemicalReaction108
pathway component: BiochemicalReaction107
pathway component: BiochemicalReaction116
pathway component: BiochemicalReaction115
pathway component: BiochemicalReaction112
pathway component: BiochemicalReaction106
pathway component: BiochemicalReaction110
pathway component: BiochemicalReaction113
pathway component: BiochemicalReaction105
pathway component: BiochemicalReaction114
pathway component: BiochemicalReaction111
evidence: Evidence203
xref: UnificationXref1376
xref: UnificationXref1375
xref: RelationshipXref183
pathway order: PathwayStep194
pathway order: PathwayStep199
pathway order: PathwayStep196
pathway order: PathwayStep192
pathway order: PathwayStep195
pathway order: PathwayStep197
pathway order: PathwayStep198
pathway order: PathwayStep193
pathway order: PathwayStep191
pathway order: PathwayStep200
pathway order: PathwayStep189
pathway order: PathwayStep190
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

early endosome lumen
type: CellularLocationVocabulary
xref: UnificationXref4393

late endosome lumen
type: CellularLocationVocabulary
xref: UnificationXref4410

RelationshipXref664
type: RelationshipXref
id: 1222356
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222356

RelationshipXref665
type: RelationshipXref
id: 1243097
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1243097

RelationshipXref666
type: RelationshipXref
id: GO:0016614
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref667
type: RelationshipXref
id: 1500763
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500763

RelationshipXref660
type: RelationshipXref
id: GO:0004148
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref661
type: RelationshipXref
id: 1222335
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222335

http://identifiers.org/pubmed/15591059
type: PublicationXref
id: 15591059
author: Wang, Y
author: Muallem, S
author: Shcheynikov, N
author: Kim, KH
db: Pubmed
title: SLC26A7 is a Cl- channel regulated by intracellular pH
source: J Biol Chem 280:6463-70
year: 2005

RelationshipXref662
type: RelationshipXref
id: 1222743
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222743

RelationshipXref663
type: RelationshipXref
id: GO:0004791
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref668
type: RelationshipXref
id: GO:0045454
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/16866376
type: PublicationXref
id: 16866376
author: Padovani, Dominique
author: Banerjee, Ruma
db: Pubmed
title: Assembly and protection of the radical enzyme, methylmalonyl-CoA mutase, by its chaperone
source: Biochemistry 45:9300-6
year: 2006

RelationshipXref669
type: RelationshipXref
id: GO:0015891
db: GENE ONTOLOGY
relationship type: MI:0359

G-protein mediated events
type: Pathway
data source: Provenance1
pathway component: PLC beta mediated events
evidence: Evidence718
xref: UnificationXref4973
xref: UnificationXref4974
pathway order: PathwayStep736
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Blood coagulation
type: Pathway
data source: Provenance1
pathway component: REACT 154948.3
pathway component: REACT 82964.9
evidence: Evidence560
xref: UnificationXref3737
xref: RelationshipXref535
xref: UnificationXref3738
pathway order: PathwayStep551
pathway order: PathwayStep547
display name: Hemostasis
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

MT2272
type: ProteinReference
name: MTCY190.26
name: sucB
name: dlaT
name: UniProt:P65633 dlaT
name: Rv2215
xref: UnificationXref4828
comment: FUNCTION Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).FUNCTION Together with AhpC, AhpD and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system.FUNCTION Appears to be essential for Mtb pathogenesis.CATALYTIC ACTIVITY Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.COFACTOR Binds 2 lipoyl cofactors covalently.ENZYME REGULATION Inhibited by rhodanine compounds. Some of them almost exclusively kill non-replicating mycobacteria in synergy with products of host immunity, such as nitric oxide and hypoxia, and are effective on bacteria within macrophages.SUBUNIT Forms a 24-polypeptide structural core with octahedral symmetry (By similarity). Identified in a complex with AhpC, AhpD and Lpd. Also makes part of the PDH complex, consisting of multiple copies of AceE (E1), DlaT (E2) and Lpd (E3).DISRUPTION PHENOTYPE Cells lacking this gene show severely retarded growth in vitro, and display no PDH activity. They are also more sensitive to nitrosative stress caused by NaNO(2), and to macrophage-induced killing in vitro. They also show at least 20-fold reduction in survival in a mouse tuberculosis model, and are unable to cause disease in a guinea pig model of tuberculosis infection. Disruption of dlaT leads to high up-regulation of the expression of the bkdABC operon.MISCELLANEOUS Is the only lipoylated protein in strain H37Rv grown on a standard rich medium. However, in a DlaT-deficient strain, another protein, BkdC, becomes lipoylated.SIMILARITY Belongs to the 2-oxoacid dehydrogenase family.SIMILARITY Contains 1 E3-binding domain.SIMILARITY Contains 2 lipoyl-binding domains.
organism: BioSource1

RelationshipXref655
type: RelationshipXref
id: 1222643
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222643

RelationshipXref656
type: RelationshipXref
id: GO:0052059
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref653
type: RelationshipXref
id: 1222563
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222563

RelationshipXref654
type: RelationshipXref
id: GO:0008785
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref651
type: RelationshipXref
id: 1222554
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222554

RelationshipXref652
type: RelationshipXref
id: GO:0004096
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref650
type: RelationshipXref
id: GO:0004601
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/18321209
type: PublicationXref
id: 18321209
author: Jansen, T
author: Daiber, A
author: Schulz, E
author: Wenzel, P
author: Münzel, T
db: Pubmed
title: Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension
source: Antioxid Redox Signal 10:1115-26
year: 2008

RelationshipXref659
type: RelationshipXref
id: 1222698
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222698

RelationshipXref657
type: RelationshipXref
id: GO:0015036
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref658
type: RelationshipXref
id: 1222602
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222602

http://identifiers.org/pubmed/10485994
type: PublicationXref
id: 10485994
author: Kamath, SG
author: Smith, CH
author: Way, BA
author: Furesz, TC
db: Pubmed
title: Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1
source: J Membr Biol 171:55-62
year: 1999

(S)-3-Hydroxydodecanoyl-CoA [ChEBI:27668]
type: SmallMoleculeReference
name: (S)-3-Hydroxydodecanoyl-CoA
xref: UnificationXref838

Serine biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction230
pathway component: BiochemicalReaction229
evidence: Evidence378
xref: RelationshipXref383
xref: UnificationXref2669
xref: UnificationXref2668
pathway order: PathwayStep375
pathway order: PathwayStep374
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Synthesis of GDP-mannose
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction4
evidence: Evidence20
xref: UnificationXref82
xref: RelationshipXref14
xref: UnificationXref83
pathway order: PathwayStep18
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref681
type: RelationshipXref
id: 4235029
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235029

RelationshipXref680
type: RelationshipXref
id: GO:0048011
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/12522561
type: PublicationXref
id: 12522561
author: Islam, Rafiqul
author: Storch, Stephan
author: Wittenstein, Birgit
author: Braulke, T
author: Sly, WS
author: Ullrich, K
db: Pubmed
title: Mutational analysis in longest known survivor of mucopolysaccharidosis type VII
source: Hum. Genet. 112:190-4
year: 2003

RelationshipXref682
type: RelationshipXref
id: GO:0004512
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref683
type: RelationshipXref
id: 879307
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879307

RelationshipXref684
type: RelationshipXref
id: GO:0008375
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref685
type: RelationshipXref
id: 879249
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879249

RelationshipXref686
type: RelationshipXref
id: 879329
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879329

RelationshipXref687
type: RelationshipXref
id: GO:0035446
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref688
type: RelationshipXref
id: 879310
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879310

RelationshipXref689
type: RelationshipXref
id: GO:0035447
db: GENE ONTOLOGY
relationship type: MI:0355

half cystine
type: SequenceModificationVocabulary
xref: UnificationXref2235

Signal Transduction
type: Pathway
data source: Provenance1
pathway component: Fibroblast Growth Factor Receptor (FGFR) signaling
pathway component: REACT 166191.1
pathway component: REACT 114367.8
pathway component: Epidermal Growth Factor Receptor (EGFR) signaling
pathway component: REACT 86395.9
pathway component: REACT 118459.7
pathway component: REACT 30900.10
pathway component: Signaling by PDGF
evidence: Evidence725
xref: UnificationXref4988
xref: UnificationXref4987
pathway order: PathwayStep726
pathway order: PathwayStep743
pathway order: PathwayStep740
pathway order: PathwayStep724
pathway order: PathwayStep728
pathway order: PathwayStep490
pathway order: PathwayStep496
pathway order: PathwayStep488
display name: Signaling Pathways
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref670
type: RelationshipXref
id: GO:0015343
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref673
type: RelationshipXref
id: 1222683
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222683

RelationshipXref674
type: RelationshipXref
id: GO:0004322
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref671
type: RelationshipXref
id: 1222570
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1222570

RelationshipXref672
type: RelationshipXref
id: GO:0052873
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref677
type: RelationshipXref
id: GO:0033214
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref678
type: RelationshipXref
id: GO:0052572
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref675
type: RelationshipXref
id: 1562602
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1562602

RelationshipXref676
type: RelationshipXref
id: 1562606
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1562606

RelationshipXref679
type: RelationshipXref
id: GO:0007202
db: GENE ONTOLOGY
relationship type: MI:0359

2-Methylprop-2-enoyl-CoA [ChEBI:27754]
type: SmallMoleculeReference
name: Methacrylyl-CoA
name: 2-Methylprop-2-enoyl-CoA
name: Methylacrylyl-CoA
xref: UnificationXref2750

UniProt:P65668 cysH
type: ProteinReference
name: cysH
name: MTCY253.29c
name: MT2462
name: Rv2392
xref: UnificationXref5204
comment: CATALYTIC ACTIVITY Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.PATHWAY Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.MISCELLANEOUS Was identified as a high-confidence drug target.SIMILARITY Belongs to the PAPS reductase family. CysH subfamily.
organism: BioSource1

UnificationXref594
type: UnificationXref
id: 176478
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176478

UnificationXref593
type: UnificationXref
id: REACT_129886
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129886.5

UnificationXref596
type: UnificationXref
id: CHEBI:26125
db: ChEBI

http://identifiers.org/pubmed/11780753
type: PublicationXref
id: 11780753
author: Joost, HG
author: Thorens, B
db: Pubmed
title: The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review)
source: Mol Membr Biol 18:247-56
year: 2001

UnificationXref595
type: UnificationXref
id: REACT_7756
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7756.3

UnificationXref590
type: UnificationXref
id: 4234606
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234606

UnificationXref592
type: UnificationXref
id: 4236208
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236208

UnificationXref591
type: UnificationXref
id: REACT_130662
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130662.5

MT1323
type: ProteinReference
name: UniProt:P65670 cysD
name: Rv1285
name: cysD
name: MTCY373.04
xref: UnificationXref5168
comment: CATALYTIC ACTIVITY ATP + sulfate = diphosphate + adenylyl sulfate.PATHWAY Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.SUBUNIT Heterodimer composed of CysD, the smaller subunit, and CysNC.INDUCTION Induced by sulfur limitation and oxidative stress. Repressed by the presence of cysteine.MISCELLANEOUS Was identified as a high-confidence drug target.SIMILARITY Belongs to the PAPS reductase family. CysD subfamily.
organism: BioSource1

UnificationXref586
type: UnificationXref
id: REACT_7394
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7394.2

UnificationXref587
type: UnificationXref
id: CHEBI:18035
db: ChEBI

UnificationXref588
type: UnificationXref
id: 174675
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174675

UnificationXref589
type: UnificationXref
id: REACT_7775
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7775.3

UnificationXref585
type: UnificationXref
id: 171126
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=171126

UnificationXref584
type: UnificationXref
id: CHEBI:17855
db: ChEBI

UnificationXref583
type: UnificationXref
id: REACT_129821
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129821.5

UnificationXref582
type: UnificationXref
id: 4234605
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234605

UnificationXref581
type: UnificationXref
id: REACT_9588
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9588.2

UnificationXref580
type: UnificationXref
id: 192438
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192438

UnificationXref579
type: UnificationXref
id: CHEBI:17754
db: ChEBI

UnificationXref577
type: UnificationXref
id: 192457
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192457

UnificationXref578
type: UnificationXref
id: REACT_9663
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9663.3

UnificationXref575
type: UnificationXref
id: REACT_132797
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132797.5

UnificationXref576
type: UnificationXref
id: CHEBI:17389
db: ChEBI

UniProt:P65686
type: ProteinReference
xref: UnificationXref301
organism: BioSource1

Rv2238c
type: ProteinReference
name: UniProt:P65688 Rv2238c
name: MT2298
name: MTCY427.19c
xref: UnificationXref4676
comment: CATALYTIC ACTIVITY 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.SIMILARITY Belongs to the AhpC/TSA family.SIMILARITY Contains 1 thioredoxin domain.
organism: BioSource1

UniProt:P65682
type: ProteinReference
xref: UnificationXref2410
organism: BioSource1

UnificationXref570
type: UnificationXref
id: 192483
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192483

UnificationXref572
type: UnificationXref
id: 4234600
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234600

UnificationXref571
type: UnificationXref
id: REACT_9533
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9533.2

UnificationXref574
type: UnificationXref
id: 4234603
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234603

UnificationXref573
type: UnificationXref
id: 4234601
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234601

UnificationXref564
type: UnificationXref
id: CHEBI:36274
db: ChEBI

UnificationXref565
type: UnificationXref
id: 192473
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192473

UnificationXref566
type: UnificationXref
id: REACT_9554
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9554.1

UnificationXref567
type: UnificationXref
id: CHEBI:9407
db: ChEBI

UnificationXref568
type: UnificationXref
id: 192415
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192415

UnificationXref569
type: UnificationXref
id: REACT_9794
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9794.1

UnificationXref563
type: UnificationXref
id: REACT_9736
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9736.1

UnificationXref562
type: UnificationXref
id: 192442
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192442

UnificationXref561
type: UnificationXref
id: CHEBI:16755
db: ChEBI

UnificationXref560
type: UnificationXref
id: REACT_9642
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9642.1

UnificationXref555
type: UnificationXref
id: CHEBI:17687
db: ChEBI

UnificationXref556
type: UnificationXref
id: 192464
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192464

UnificationXref553
type: UnificationXref
id: 192431
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192431

UnificationXref554
type: UnificationXref
id: REACT_9608
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9608.1

UnificationXref559
type: UnificationXref
id: 192421
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192421

UnificationXref557
type: UnificationXref
id: REACT_9858
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9858.1

UnificationXref558
type: UnificationXref
id: CHEBI:28865
db: ChEBI

UnificationXref550
type: UnificationXref
id: 4234598
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234598

UnificationXref551
type: UnificationXref
id: 4234599
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234599

UnificationXref552
type: UnificationXref
id: CHEBI:16359
db: ChEBI

UnificationXref547
type: UnificationXref
id: O53488
db: UniProt

UnificationXref546
type: UnificationXref
id: REACT_7360
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7360.2

UnificationXref549
type: UnificationXref
id: O53452
db: UniProt

UnificationXref548
type: UnificationXref
id: 4234595
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234595

UnificationXref543
type: UnificationXref
id: REACT_7844
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7844.2

UnificationXref542
type: UnificationXref
id: 174602
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174602

UnificationXref545
type: UnificationXref
id: 171149
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=171149

UnificationXref544
type: UnificationXref
id: CHEBI:16113
db: ChEBI

UnificationXref540
type: UnificationXref
id: REACT_7527
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7527.2

UnificationXref541
type: UnificationXref
id: CHEBI:15904
db: ChEBI

http://identifiers.org/pubmed/15967716
type: PublicationXref
id: 15967716
author: Martinon, F
author: Tschopp, J
db: Pubmed
title: NLRs join TLRs as innate sensors of pathogens
source: Trends Immunol 26:447-54
year: 2005

trans-Tetradec-2-enoyl-CoA
type: SmallMoleculeReference
name: trans-Tetradec-2-enoyl-CoA [ChEBI:27721]
xref: UnificationXref808

http://identifiers.org/pubmed/16788062
type: PublicationXref
id: 16788062
author: Schwer, B
author: Verdin, E
author: Andersen, JS
author: Verdin, RO
author: Bunkenborg, J
db: Pubmed
title: Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
source: Proc Natl Acad Sci U S A 103:10224-9
year: 2006

UnificationXref539
type: UnificationXref
id: 171076
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=171076

UnificationXref538
type: UnificationXref
id: CHEBI:17002
db: ChEBI

UnificationXref537
type: UnificationXref
id: REACT_3225
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3225.1

UnificationXref536
type: UnificationXref
id: 109276
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109276

UnificationXref535
type: UnificationXref
id: REACT_154046
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154046.3

UnificationXref534
type: UnificationXref
id: 4236348
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236348

UnificationXref533
type: UnificationXref
id: REACT_155155
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155155.3

UnificationXref532
type: UnificationXref
id: 4236347
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236347

UnificationXref531
type: UnificationXref
id: REACT_154429
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154429.3

http://identifiers.org/pubmed/22013531
type: PublicationXref
id: 22013531
author: Alves, S
author: Coutinho, MF
author: Lacerda, L
db: Pubmed
title: Glycosaminoglycan storage disorders: a review
source: Biochem Res Int 2012:471325
year: 2012

UnificationXref530
type: UnificationXref
id: 4235627
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235627

UnificationXref529
type: UnificationXref
id: REACT_150575
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150575.1

UnificationXref528
type: UnificationXref
id: 1629731
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1629731

http://identifiers.org/pubmed/18511936
type: PublicationXref
id: 18511936
author: Gray PJ, Jr
author: Calderwood, SK
author: Stevenson, MA
author: Prince, T
author: Cheng, J
db: Pubmed
title: Targeting the oncogene and kinome chaperone CDC37
source: Nat Rev Cancer 8:491-5
year: 2008

UnificationXref521
type: UnificationXref
id: REACT_152896
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152896.3

UnificationXref520
type: UnificationXref
id: 4235629
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235629

UnificationXref523
type: UnificationXref
id: 870330
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=870330

UnificationXref522
type: UnificationXref
id: CHEBI:18297
db: ChEBI

UnificationXref525
type: UnificationXref
id: 4235625
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235625

UnificationXref524
type: UnificationXref
id: REACT_27390
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27390.2

UniProt:P65690
type: ProteinReference
xref: UnificationXref176
organism: BioSource1

UnificationXref527
type: UnificationXref
id: CHEBI:18169
db: ChEBI

UnificationXref526
type: UnificationXref
id: REACT_157799
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157799.3

UnificationXref519
type: UnificationXref
id: 4235623
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235623

UnificationXref518
type: UnificationXref
id: 4235622
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235622

UnificationXref517
type: UnificationXref
id: 4235621
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235621

Metabolism of vitamins and cofactors
type: Pathway
data source: Provenance1
pathway component: Metabolism of water-soluble vitamins and cofactors
evidence: Evidence371
xref: UnificationXref2621
xref: RelationshipXref372
xref: UnificationXref2620
pathway order: PathwayStep368
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref512
type: UnificationXref
id: P65165
db: UniProt

UnificationXref511
type: UnificationXref
id: REACT_20018
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20018.2

UnificationXref510
type: UnificationXref
id: 426910
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426910

UnificationXref516
type: UnificationXref
id: 4235620
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235620

UnificationXref515
type: UnificationXref
id: 4235619
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235619

http://identifiers.org/pubmed/10488948
type: PublicationXref
id: 10488948
author: Barter, PJ
author: Clay, MA
author: Rye, KA
db: Pubmed
title: Remodelling of high density lipoproteins by plasma factors
source: Atherosclerosis 145:227-38
year: 1999

UnificationXref514
type: UnificationXref
id: 4235618
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235618

UnificationXref513
type: UnificationXref
id: 4235617
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235617

Pyridoxine phosphate [ChEBI:8672]
type: SmallMoleculeReference
name: Pyridoxine 5-phosphate
name: Pyridoxine phosphate
name: Pyridoxine 5'-phosphate
xref: UnificationXref2415

dITP
type: SmallMoleculeReference
name: 2'-Deoxyinosine 5'-triphosphate
name: dITP [ChEBI:10499]
name: 2'-Deoxyinosine-5'-triphosphate
xref: UnificationXref2367

2'-Deoxyinosine 5'-phosphate [ChEBI:28806]
type: SmallMoleculeReference
name: 2'-Deoxyinosine 5'-phosphate
name: dIMP
xref: UnificationXref2370

http://identifiers.org/pubmed/22653731
type: PublicationXref
id: 22653731
author: Levin, Aron M
author: Waghray, Deepa
author: Thomas, Christoph
author: Garcia, K Christopher
author: Janda, Claudia Y
db: Pubmed
title: Structural basis of Wnt recognition by Frizzled
source: Science 337:59-64
year: 2012

http://identifiers.org/pubmed/3038863
type: PublicationXref
id: 3038863
author: Jeffrey, JJ
author: Welgus, HG
author: Hibbs, MS
author: Hasty, KA
db: Pubmed
title: The collagen substrate specificity of human neutrophil collagenase
source: J Biol Chem 262:10048-52
year: 1987

NADPH regeneration
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction100
pathway component: BiochemicalReaction101
evidence: Evidence185
xref: RelationshipXref164
xref: UnificationXref1240
xref: UnificationXref1241
pathway order: PathwayStep181
pathway order: PathwayStep182
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/9218123
type: PublicationXref
id: 9218123
author: Pasternak, GW
author: Standifer, KM
db: Pubmed
title: G proteins and opioid receptor-mediated signalling
source: Cell Signal 9:237-48
year: 1997

trxA
type: ProteinReference
name: UniProt:P0A616
name: Rv3914
name: trxC
name: MTV028.05
name: MT4033
name: trx
xref: UnificationXref5194
comment: FUNCTION: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity).
organism: BioSource1

http://identifiers.org/pubmed/2066663
type: PublicationXref
id: 2066663
author: Ameis, D
author: Sternby, B
author: Schotz, MC
author: Leete, TH
author: Reue, K
author: Ronk, M
author: Borgstrom, B
author: Lee, G
author: Zambaux, J
author: Wong, H
author: Shively, JE
db: Pubmed
title: cDNA cloning of carboxyl ester lipase from human pancreas reveals a unique proline-rich repeat unit
source: J Lipid Res 32:267-76
year: 1991

PKA-mediated phosphorylation of CREB
type: Pathway
data source: Provenance1
pathway component: PKA activation
evidence: Evidence490
xref: UnificationXref3475
xref: UnificationXref3474
pathway order: PathwayStep484
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/15272052
type: PublicationXref
id: 15272052
author: Dinh, TP
author: Piomelli, D
author: Kathuria, S
db: Pubmed
title: RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol
source: Mol Pharmacol 66:1260-4
year: 2004

http://identifiers.org/pubmed/10903473
type: PublicationXref
id: 10903473
author: Sprecher, H
db: Pubmed
title: Metabolism of highly unsaturated n-3 and n-6 fatty acids
source: Biochim Biophys Acta 1486:219-31
year: 2000

MT1869
type: ProteinReference
name: MTCY1A11.22c
name: Rv1821
name: secA2
name: UniProt:P66785 secA2
xref: UnificationXref4774
comment: SIMILARITY Belongs to the SecA family.
organism: BioSource1

Urea synthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction250
pathway component: BiochemicalReaction251
pathway component: BiochemicalReaction252
pathway component: BiochemicalReaction249
evidence: Evidence406
xref: RelationshipXref420
xref: UnificationXref2870
xref: UnificationXref2869
pathway order: PathwayStep400
pathway order: PathwayStep403
pathway order: PathwayStep402
pathway order: PathwayStep401
display name: Urea cycle
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/17177598
type: PublicationXref
id: 17177598
author: DeBiasi, RM
author: Leahy, DJ
author: Paez, JG
author: Yoshimoto, K
author: O'Neill, K
author: Thomas, RK
author: Cloughesy, T
author: Greulich, H
author: Yuza, Y
author: Ziaugra, L
author: Vivanco, I
author: Levine, RL
author: Rao, PN
author: Xu, Q
author: Gabriel, S
author: Onofrio, R
author: Lee, JC
author: Glatt, KA
author: Nghiemphu, P
author: Peck, TC
author: Liau, LM
author: Huang, JHY
author: Beroukhim, R
author: King, JC
author: Linhart, DJ
author: Kawaguchi, T
author: Sellers, WR
author: Mellinghoff, IK
author: Meyerson, M
author: Feng, WL
author: Getz, G
author: Nelson, SF
author: Mischel, P
author: Sawyers, CL
author: Pieper, RO
author: Khan, H
db: Pubmed
title: Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain
source: PLoS Med 3:e485
year: 2006

UniProt:P66791 secG
type: ProteinReference
name: secG
name: MTCY493.14c
name: Rv1440
name: MT1485
xref: UnificationXref4768
comment: SIMILARITY Belongs to the SecG family.
organism: BioSource1

Gluconeogenesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction20
pathway component: BiochemicalReaction16
pathway component: BiochemicalReaction14
pathway component: BiochemicalReaction21
pathway component: BiochemicalReaction18
pathway component: BiochemicalReaction15
pathway component: BiochemicalReaction19
pathway component: BiochemicalReaction17
evidence: Evidence57
xref: RelationshipXref39
xref: UnificationXref322
xref: UnificationXref323
pathway order: PathwayStep51
pathway order: PathwayStep53
pathway order: PathwayStep47
pathway order: PathwayStep50
pathway order: PathwayStep49
pathway order: PathwayStep54
pathway order: PathwayStep48
pathway order: PathwayStep52
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

dCDP
type: SmallMoleculeReference
name: dCDP [ChEBI:28846]
name: 2'-Deoxycytidine diphosphate
name: 2'-Deoxycytidine 5'-diphosphate
xref: UnificationXref2227

http://identifiers.org/pubmed/11275267
type: PublicationXref
id: 11275267
author: Zoeller, RA
author: Nagan, N
db: Pubmed
title: Plasmalogens: biosynthesis and functions
source: Prog Lipid Res 40:199-229
year: 2001

UnificationXref1771
type: UnificationXref
id: REACT_133458
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133458.5

UnificationXref1770
type: UnificationXref
id: 4236328
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236328

UnificationXref1775
type: UnificationXref
id: REACT_5798
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5798.3

UnificationXref1774
type: UnificationXref
id: 29938
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29938

UnificationXref1773
type: UnificationXref
id: REACT_134613
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134613.5

UnificationXref1772
type: UnificationXref
id: 4236329
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236329

UnificationXref1779
type: UnificationXref
id: REACT_3871
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3871.2

UnificationXref1778
type: UnificationXref
id: 113594
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113594

UnificationXref1777
type: UnificationXref
id: REACT_5783
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5783.1

UnificationXref1776
type: UnificationXref
id: 113563
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113563

5'-Phosphoribosyl-5-aminoimidazole [ChEBI:28843]
type: SmallMoleculeReference
name: 5'-Phosphoribosyl-5-aminoimidazole
name: Aminoimidazole ribotide
name: 1-(5'-Phosphoribosyl)-5-aminoimidazole
name: 1-(5-Phospho-D-ribosyl)-5-aminoimidazole
name: AIR
xref: UnificationXref1900

http://identifiers.org/pubmed/17170135
type: PublicationXref
id: 17170135
author: Li, JL
author: Gimeno, RE
author: Li, D
author: Tobin, JF
author: Cao, J
db: Pubmed
title: Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis
source: Proc Natl Acad Sci U S A 103:19695-700
year: 2006

Epidermal Growth Factor Receptor (EGFR) signaling
type: Pathway
data source: Provenance1
pathway component: EGFR interacts with phospholipase C-gamma
evidence: Evidence495
xref: UnificationXref3485
xref: RelationshipXref509
xref: UnificationXref3484
pathway order: PathwayStep489
display name: Signaling by EGFR
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1760
type: UnificationXref
id: 4235508
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235508

UnificationXref1762
type: UnificationXref
id: 29870
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29870

UnificationXref1761
type: UnificationXref
id: CHEBI:15372
db: ChEBI

UnificationXref1764
type: UnificationXref
id: 4235509
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235509

UnificationXref1763
type: UnificationXref
id: REACT_2495
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2495.2

http://identifiers.org/pubmed/8567683
type: PublicationXref
id: 8567683
author: Beardsley, GP
author: Moroson, BA
author: Rayl, EA
db: Pubmed
title: The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
source: J Biol Chem 271:2225-2233
year: 1996

UnificationXref1766
type: UnificationXref
id: 29502
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29502

UnificationXref1765
type: UnificationXref
id: CHEBI:17295
db: ChEBI

dUDP [ChEBI:28850]
type: SmallMoleculeReference
name: 2'-Deoxyuridine 5'-diphosphate
name: dUDP
xref: UnificationXref2230

UnificationXref1768
type: UnificationXref
id: 4236327
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236327

UnificationXref1767
type: UnificationXref
id: REACT_4077
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4077.3

UnificationXref1769
type: UnificationXref
id: REACT_133722
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133722.5

UnificationXref1797
type: UnificationXref
id: 4233793
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233793

UnificationXref1796
type: UnificationXref
id: O53446
db: UniProt

UnificationXref1795
type: UnificationXref
id: REACT_4778
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4778.2

UnificationXref1794
type: UnificationXref
id: 113544
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113544

UnificationXref1793
type: UnificationXref
id: REACT_5289
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5289.2

UnificationXref1792
type: UnificationXref
id: 113588
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113588

UnificationXref1791
type: UnificationXref
id: CHEBI:18012
db: ChEBI

UnificationXref1790
type: UnificationXref
id: REACT_135388
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135388.5

http://identifiers.org/pubmed/12495737
type: PublicationXref
id: 12495737
author: Elliott, T
author: Antoniou, AN
author: Powis, SJ
db: Pubmed
title: Assembly and export of MHC class I peptide ligands
source: Curr Opin Immunol 15:75-81
year: 2003

UnificationXref1799
type: UnificationXref
id: 4233796
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233796

UnificationXref1798
type: UnificationXref
id: 4233794
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233794

UnificationXref598
type: UnificationXref
id: REACT_13916
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13916.1

UnificationXref597
type: UnificationXref
id: 265525
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265525

UnificationXref599
type: UnificationXref
id: 265784
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265784

http://identifiers.org/pubmed/3391615
type: PublicationXref
id: 3391615
author: Robertson, D A
author: Baker, E G
author: Morris, C P
author: Hopwood, J J
author: Callen, D F
db: Pubmed
title: Chromosomal localization of the gene for human glucosamine-6-sulphatase to 12q14
source: Hum. Genet. 79:175-8
year: 1988

UnificationXref1784
type: UnificationXref
id: 4235150
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235150

UnificationXref1783
type: UnificationXref
id: 4235148
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235148

UnificationXref1786
type: UnificationXref
id: P30234
db: UniProt

UnificationXref1785
type: UnificationXref
id: REACT_138431
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138431.5

UnificationXref1780
type: UnificationXref
id: 113600
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113600

UnificationXref1782
type: UnificationXref
id: 4235147
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235147

UnificationXref1781
type: UnificationXref
id: REACT_5633
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5633.1

UnificationXref1788
type: UnificationXref
id: 4235144
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235144

UnificationXref1787
type: UnificationXref
id: 4235143
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235143

UnificationXref1789
type: UnificationXref
id: 4235146
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235146

RelationshipXref520
type: RelationshipXref
id: GO:0003867
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1980
type: UnificationXref
id: 500172
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500172

UnificationXref1983
type: UnificationXref
id: 29382
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29382

RelationshipXref524
type: RelationshipXref
id: GO:0007269
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1984
type: UnificationXref
id: REACT_3820
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3820.1

RelationshipXref523
type: RelationshipXref
id: 4235258
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235258

UnificationXref1981
type: UnificationXref
id: REACT_21661
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21661.1

RelationshipXref522
type: RelationshipXref
id: GO:0004777
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1982
type: UnificationXref
id: CHEBI:16134
db: ChEBI

RelationshipXref521
type: RelationshipXref
id: 4235293
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235293

UnificationXref1987
type: UnificationXref
id: 4234033
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234033

RelationshipXref528
type: RelationshipXref
id: GO:0004016
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1988
type: UnificationXref
id: REACT_114346
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114346.8

RelationshipXref527
type: RelationshipXref
id: GO:0042136
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1985
type: UnificationXref
id: P63907
db: UniProt

RelationshipXref526
type: RelationshipXref
id: 4234891
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234891

UnificationXref1986
type: UnificationXref
id: 4234031
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234031

RelationshipXref525
type: RelationshipXref
id: GO:0008168
db: GENE ONTOLOGY
relationship type: MI:0355

UniProt:P63985
type: ProteinReference
xref: UnificationXref4218
organism: BioSource1

UnificationXref1989
type: UnificationXref
id: CHEBI:40196
db: ChEBI

UniProt:P63987
type: ProteinReference
xref: UnificationXref4220
organism: BioSource1

RelationshipXref529
type: RelationshipXref
id: 4235129
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235129

http://identifiers.org/pubmed/9536089
type: PublicationXref
id: 9536089
author: Hogenhout, EM
author: Muijsers, AO
author: Caruso, U
author: Ofman, R
author: Hettema, EH
author: Wanders, RJ
db: Pubmed
title: Acyl-CoA:dihydroxyacetonephosphate acyltransferase: cloning of the human cDNA and resolution of the molecular basis in rhizomelic chondrodysplasia punctata type 2
source: Hum Mol Genet 7:847-53
year: 1998

UnificationXref1990
type: UnificationXref
id: 2161190
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161190

UnificationXref1991
type: UnificationXref
id: REACT_124972
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124972.1

UnificationXref1992
type: UnificationXref
id: CHEBI:16830
db: ChEBI

RelationshipXref511
type: RelationshipXref
id: GO:0070290
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1993
type: UnificationXref
id: 2161177
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161177

RelationshipXref510
type: RelationshipXref
id: GO:0008543
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1994
type: UnificationXref
id: REACT_124901
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124901.1

RelationshipXref513
type: RelationshipXref
id: 4235253
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235253

UnificationXref1995
type: UnificationXref
id: 29426
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29426

RelationshipXref512
type: RelationshipXref
id: 4235970
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235970

UnificationXref1996
type: UnificationXref
id: REACT_3201
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3201.3

RelationshipXref515
type: RelationshipXref
id: 4234886
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234886

UnificationXref1997
type: UnificationXref
id: 4235796
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235796

RelationshipXref514
type: RelationshipXref
id: GO:0015171
db: GENE ONTOLOGY
relationship type: MI:0355

2'-Deoxyguanosine 5'-diphosphate
type: SmallMoleculeReference
name: dGDP [ChEBI:28862]
name: dGDP
xref: UnificationXref2224

UnificationXref1998
type: UnificationXref
id: 4235797
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235797

RelationshipXref517
type: RelationshipXref
id: 4234881
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234881

UnificationXref1999
type: UnificationXref
id: 4235799
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235799

RelationshipXref516
type: RelationshipXref
id: 4234876
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234876

RelationshipXref519
type: RelationshipXref
id: GO:0042133
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref518
type: RelationshipXref
id: GO:0006865
db: GENE ONTOLOGY
relationship type: MI:0359

Taurocholate [ChEBI:9408]
type: SmallMoleculeReference
name: Cholyltaurine
name: Taurocholic acid
name: Taurocholate
xref: UnificationXref558

UnificationXref1961
type: UnificationXref
id: 4234341
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234341

RelationshipXref502
type: RelationshipXref
id: 4235814
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235814

UnificationXref1962
type: UnificationXref
id: 4233994
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233994

RelationshipXref501
type: RelationshipXref
id: GO:0006855
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref500
type: RelationshipXref
id: 4235802
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235802

UnificationXref1960
type: UnificationXref
id: 4234343
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234343

UnificationXref1969
type: UnificationXref
id: CHEBI:17256
db: ChEBI

RelationshipXref509
type: RelationshipXref
id: GO:0007173
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1967
type: UnificationXref
id: 83909
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83909

RelationshipXref508
type: RelationshipXref
id: GO:0007165
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1968
type: UnificationXref
id: REACT_5822
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5822.2

RelationshipXref507
type: RelationshipXref
id: GO:0034199
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1965
type: UnificationXref
id: REACT_94126
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94126.9

RelationshipXref506
type: RelationshipXref
id: 4234410
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234410

UnificationXref1966
type: UnificationXref
id: CHEBI:16335
db: ChEBI

RelationshipXref505
type: RelationshipXref
id: GO:0008294
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1963
type: UnificationXref
id: REACT_101613
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101613.9

RelationshipXref504
type: RelationshipXref
id: GO:0044281
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1964
type: UnificationXref
id: 4236092
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236092

RelationshipXref503
type: RelationshipXref
id: GO:0017144
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/17125408
type: PublicationXref
id: 17125408
author: Baltes, E
author: Strolin Benedetti, M
author: Whomsley, R
db: Pubmed
title: Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics
source: Expert Opin Drug Metab Toxicol 2:895-921
year: 2006

http://identifiers.org/pubmed/3090932
type: PublicationXref
id: 3090932
author: Griffith, OW
db: Pubmed
title: Beta-amino acids: mammalian metabolism and utility as alpha-amino acid analogues
source: Annu Rev Biochem 55:855-878
year: 1986

UnificationXref1970
type: UnificationXref
id: 83925
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83925

UnificationXref1971
type: UnificationXref
id: REACT_3734
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3734.2

UnificationXref1972
type: UnificationXref
id: 500173
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500173

UnificationXref1973
type: UnificationXref
id: REACT_21870
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21870.1

http://identifiers.org/pubmed/12713736
type: PublicationXref
id: 12713736
author: Lee, A
author: Markovich, D
author: Regeer, RR
db: Pubmed
title: Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1)
source: DNA Cell Biol 22:107-17
year: 2003

UnificationXref1978
type: UnificationXref
id: 109331
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109331

UnificationXref1979
type: UnificationXref
id: REACT_4959
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4959.2

UnificationXref1974
type: UnificationXref
id: CHEBI:17596
db: ChEBI

UnificationXref1975
type: UnificationXref
id: 83927
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83927

UnificationXref1976
type: UnificationXref
id: REACT_3272
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3272.2

UnificationXref1977
type: UnificationXref
id: CHEBI:28997
db: ChEBI

http://identifiers.org/pubmed/9473669
type: PublicationXref
id: 9473669
author: Fukuoka, SI
author: Nyaruhucha, CM
author: Shibata, K
db: Pubmed
title: Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase
source: Biochim Biophys Acta 1395:192-201
year: 1998

http://identifiers.org/pubmed/10970791
type: PublicationXref
id: 10970791
author: Bocianski, A
author: Joost, HG
author: Doege, H
author: Schürmann, A
db: Pubmed
title: Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes
source: Biochem J 350:771-6
year: 2000

UnificationXref1944
type: UnificationXref
id: REACT_4653
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4653.3

UnificationXref1943
type: UnificationXref
id: 29448
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29448

UnificationXref1942
type: UnificationXref
id: CHEBI:17053
db: ChEBI

UnificationXref1941
type: UnificationXref
id: REACT_109470
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_109470.9

UnificationXref1948
type: UnificationXref
id: P65880
db: UniProt

UnificationXref1947
type: UnificationXref
id: REACT_5442
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5442.2

UnificationXref1946
type: UnificationXref
id: 35141
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=35141

UnificationXref1945
type: UnificationXref
id: CHEBI:15919
db: ChEBI

http://identifiers.org/pubmed/2844759
type: PublicationXref
id: 2844759
author: Verma, AK
author: Strehler, EE
author: Filoteo, AG
author: Vogel, G
author: Penniston, JT
author: Stanford, DR
author: Wieben, ED
author: Fischer, R
author: Heim, R
author: Mathews, S
db: Pubmed
title: Complete primary structure of a human plasma membrane Ca2+ pump
source: J Biol Chem 263:14152-9
year: 1988

UnificationXref1940
type: UnificationXref
id: 4233943
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233943

http://identifiers.org/pubmed/1976634
type: PublicationXref
id: 1976634
author: Hurwitz, J
author: Lee, SH
author: Kwong, AD
db: Pubmed
title: The in vitro replication of DNA containing the SV40 origin.
source: J Biol Chem 265:18043-6
year: 1990

UnificationXref1938
type: UnificationXref
id: P0A5A1
db: UniProt

UnificationXref1939
type: UnificationXref
id: 4233941
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233941

UnificationXref1953
type: UnificationXref
id: 4234335
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234335

UnificationXref1952
type: UnificationXref
id: 4234334
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234334

UnificationXref1955
type: UnificationXref
id: 4234337
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234337

UnificationXref1954
type: UnificationXref
id: 4234336
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234336

UnificationXref1957
type: UnificationXref
id: REACT_92014
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92014.9

UnificationXref1956
type: UnificationXref
id: 4234339
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234339

UnificationXref1959
type: UnificationXref
id: 4234340
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234340

UnificationXref1958
type: UnificationXref
id: 4234342
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234342

UnificationXref1951
type: UnificationXref
id: 4234333
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234333

UnificationXref1950
type: UnificationXref
id: 4234332
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234332

UnificationXref1949
type: UnificationXref
id: 4234331
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234331

Cytosolic sulfonation of small molecules
type: Pathway
data source: Provenance1
pathway component: Transport and synthesis of PAPS
evidence: Evidence463
xref: UnificationXref3258
xref: UnificationXref3257
xref: RelationshipXref489
pathway order: PathwayStep79
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1926
type: UnificationXref
id: REACT_82475
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82475.9

UnificationXref1925
type: UnificationXref
id: 4233958
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233958

UnificationXref1924
type: UnificationXref
id: 4233954
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233954

UnificationXref1923
type: UnificationXref
id: 4233953
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233953

UnificationXref1922
type: UnificationXref
id: P67541
db: UniProt

UnificationXref1921
type: UnificationXref
id: REACT_4103
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4103.2

UnificationXref1920
type: UnificationXref
id: 111427
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111427

http://identifiers.org/pubmed/19244215
type: PublicationXref
id: 19244215
author: Buczynski, MW
author: Dumlao, DS
author: Dennis, EA
db: Pubmed
title: Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology
source: J Lipid Res 50:1015-38
year: 2009

http://identifiers.org/pubmed/15837620
type: PublicationXref
id: 15837620
author: Li, S
author: Schmitz, KR
author: Ferguson, KM
author: Kussie, P
author: Wiltzius, JJW
author: Jeffrey, PD
db: Pubmed
title: Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
source: Cancer Cell 7:301-11
year: 2005

http://identifiers.org/pubmed/12648452
type: PublicationXref
id: 12648452
author: Buttgereit, F
author: Qian, SB
author: Finzi, D
author: Princiotta, MF
author: Yewdell, JW
author: Gibbs, J
author: Bennink, JR
author: Schuchmann, S
db: Pubmed
title: Quantitating protein synthesis, degradation, and endogenous antigen processing
source: Immunity 18:343-54
year: 2003

http://identifiers.org/pubmed/17371050
type: PublicationXref
id: 17371050
author: Kondo, N
author: Fukao, T
author: Haapalainen, AM
author: Wierenga, RK
author: Meriläinen, G
author: Pirilä, PL
db: Pubmed
title: Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function
source: Biochemistry 46:4305-21
year: 2007

UnificationXref1918
type: UnificationXref
id: REACT_95334
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95334.9

UnificationXref1919
type: UnificationXref
id: CHEBI:18381
db: ChEBI

UnificationXref1916
type: UnificationXref
id: 4233962
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233962

UnificationXref1917
type: UnificationXref
id: 4233964
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233964

UnificationXref1935
type: UnificationXref
id: 4233949
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233949

UnificationXref1934
type: UnificationXref
id: 4233947
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233947

UnificationXref1937
type: UnificationXref
id: 4233950
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233950

UnificationXref1936
type: UnificationXref
id: REACT_77612
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77612.9

UnificationXref1931
type: UnificationXref
id: REACT_3823
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3823.2

UnificationXref1930
type: UnificationXref
id: 111584
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111584

UnificationXref1933
type: UnificationXref
id: 4233946
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233946

UnificationXref1932
type: UnificationXref
id: P65167
db: UniProt

http://identifiers.org/pubmed/1860888
type: PublicationXref
id: 1860888
author: Cummings, CE
author: Kwan, AP
author: Chapman, JA
author: Grant, ME
db: Pubmed
title: Macromolecular organization of chicken type X collagen in vitro
source: J Cell Biol 114:597-604
year: 1991

http://identifiers.org/pubmed/12176987
type: PublicationXref
id: 12176987
author: Tanabe, K
author: Tanaka, AR
author: Ueda, K
author: Morita, M
author: Kurisu, M
author: Matsuo, M
author: Kasiwayama, Y
author: Kioka, N
author: Imanaka, T
author: Amachi, T
db: Pubmed
title: ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1)
source: J Biol Chem 277:40142-7
year: 2002

http://identifiers.org/pubmed/11698644
type: PublicationXref
id: 11698644
author: Kabashima, T
author: Uyeda, K
author: Kawaguchi, T
author: Takenoshita, M
db: Pubmed
title: Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein
source: Proc Natl Acad Sci U S A 98:13710-5
year: 2001

UnificationXref1927
type: UnificationXref
id: 4233956
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233956

UnificationXref1928
type: UnificationXref
id: REACT_100264
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100264.9

UnificationXref1929
type: UnificationXref
id: CHEBI:15652
db: ChEBI

UniProt:P65700
type: ProteinReference
xref: UnificationXref218
organism: BioSource1

http://identifiers.org/pubmed/14551214
type: PublicationXref
id: 14551214
author: Blanck, TJ
author: Xu, Y
author: Kelley, RI
author: Schlame, M
db: Pubmed
title: Remodeling of cardiolipin by phospholipid transacylation
source: J Biol Chem 278:51380-5
year: 2003

http://identifiers.org/pubmed/13416257
type: PublicationXref
id: 13416257
author: Robinson, WG
author: Coon, MJ
db: Pubmed
title: Purification and properties of beta-hydroxyisobutyric dehydrogenase
source: J Biol Chem 225:511-521
year: 1957

UniProt:P63907
type: ProteinReference
xref: UnificationXref1985
organism: BioSource1

UnificationXref1900
type: UnificationXref
id: CHEBI:28843
db: ChEBI

UnificationXref1901
type: UnificationXref
id: 111370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111370

UnificationXref1902
type: UnificationXref
id: REACT_4927
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4927.2

UnificationXref1903
type: UnificationXref
id: 4233969
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233969

UnificationXref1904
type: UnificationXref
id: REACT_88385
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88385.9

UnificationXref1908
type: UnificationXref
id: CHEBI:37154
db: ChEBI

UnificationXref1907
type: UnificationXref
id: REACT_3661
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3661.2

UnificationXref1906
type: UnificationXref
id: 111399
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111399

UnificationXref1905
type: UnificationXref
id: CHEBI:18319
db: ChEBI

UnificationXref1909
type: UnificationXref
id: 29586
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29586

RelationshipXref592
type: RelationshipXref
id: GO:0006289
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref593
type: RelationshipXref
id: 4234981
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234981

RelationshipXref590
type: RelationshipXref
id: GO:0006297
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref591
type: RelationshipXref
id: GO:0006283
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref597
type: RelationshipXref
id: 4235499
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235499

RelationshipXref596
type: RelationshipXref
id: 4235486
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235486

RelationshipXref595
type: RelationshipXref
id: GO:0043225
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref594
type: RelationshipXref
id: 4235490
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235490

RelationshipXref599
type: RelationshipXref
id: GO:0015385
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref598
type: RelationshipXref
id: GO:0055085
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1910
type: UnificationXref
id: REACT_5412
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5412.3

UnificationXref1911
type: UnificationXref
id: CHEBI:18406
db: ChEBI

UnificationXref1914
type: UnificationXref
id: P71832
db: UniProt

UnificationXref1915
type: UnificationXref
id: 4233961
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233961

UnificationXref1912
type: UnificationXref
id: 111409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111409

UnificationXref1913
type: UnificationXref
id: REACT_2302
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2302.2

RelationshipXref580
type: RelationshipXref
id: 4234323
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234323

RelationshipXref581
type: RelationshipXref
id: GO:0003908
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref582
type: RelationshipXref
id: 4234003
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234003

Respiratory electron transport
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction153
evidence: Evidence277
xref: UnificationXref1835
xref: RelationshipXref251
xref: UnificationXref1836
pathway order: PathwayStep274
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref588
type: RelationshipXref
id: GO:0000724
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref587
type: RelationshipXref
id: GO:0006281
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref589
type: RelationshipXref
id: GO:0006302
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref584
type: RelationshipXref
id: GO:0003684
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref583
type: RelationshipXref
id: GO:0006307
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref586
type: RelationshipXref
id: 4234423
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234423

RelationshipXref585
type: RelationshipXref
id: 4234417
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234417

UniProt:P65712
type: ProteinReference
xref: UnificationXref4442
organism: BioSource1

RelationshipXref570
type: RelationshipXref
id: 4234294
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234294

RelationshipXref571
type: RelationshipXref
id: GO:0045008
db: GENE ONTOLOGY
relationship type: MI:0359

F420-6 (ox.) [ChEBI:1130536]
type: SmallMoleculeReference
name: F420-6 (ox.)
xref: UnificationXref4641

http://identifiers.org/pubmed/11470505
type: PublicationXref
id: 11470505
author: Langin, D
author: Reue, K
author: Xia, YR
author: Holm, C
author: Karlsson, M
author: Tornqvist, H
author: Lusis, AJ
db: Pubmed
title: Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene
source: Gene 272:11-8
year: 2001

RelationshipXref579
type: RelationshipXref
id: 4234321
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234321

RelationshipXref578
type: RelationshipXref
id: 4234312
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234312

RelationshipXref577
type: RelationshipXref
id: 4234309
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234309

RelationshipXref576
type: RelationshipXref
id: GO:0003887
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref575
type: RelationshipXref
id: GO:0006284
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref574
type: RelationshipXref
id: GO:0006285
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref573
type: RelationshipXref
id: 4234271
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234271

RelationshipXref572
type: RelationshipXref
id: GO:0000703
db: GENE ONTOLOGY
relationship type: MI:0355

UniProt:P63935
type: ProteinReference
xref: UnificationXref2771
organism: BioSource1

Fatty Acyl-CoA Biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction51
pathway component: Conversion of palmitic acid to very long chain fatty acyl-CoAs
pathway component: BiochemicalReaction52
pathway component: BiochemicalReaction50
evidence: Evidence110
xref: UnificationXref721
xref: UnificationXref722
xref: RelationshipXref99
pathway order: PathwayStep104
pathway order: PathwayStep103
pathway order: PathwayStep107
pathway order: PathwayStep105
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref560
type: RelationshipXref
id: GO:0004831
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref569
type: RelationshipXref
id: 4234291
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234291

UniProt:P96871
type: ProteinReference
xref: UnificationXref2957
organism: BioSource1

UniProt:P65734
type: ProteinReference
xref: UnificationXref738
organism: BioSource1

RelationshipXref561
type: RelationshipXref
id: 4234915
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234915

RelationshipXref562
type: RelationshipXref
id: 4234923
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234923

RelationshipXref563
type: RelationshipXref
id: GO:0010467
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref564
type: RelationshipXref
id: GO:0030574
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref565
type: RelationshipXref
id: GO:0022617
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref566
type: RelationshipXref
id: GO:0030198
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref567
type: RelationshipXref
id: GO:0045007
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref568
type: RelationshipXref
id: GO:0019104
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref558
type: RelationshipXref
id: GO:0004830
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref559
type: RelationshipXref
id: 4234943
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234943

RelationshipXref552
type: RelationshipXref
id: GO:0004826
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref553
type: RelationshipXref
id: 4234933
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234933

RelationshipXref550
type: RelationshipXref
id: GO:0004825
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref551
type: RelationshipXref
id: 4234909
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234909

RelationshipXref556
type: RelationshipXref
id: GO:0004828
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref557
type: RelationshipXref
id: 4234965
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234965

Pyrimidine metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 109316.9
pathway component: REACT 100843.9
pathway component: REACT 79754.9
evidence: Evidence321
xref: RelationshipXref312
xref: UnificationXref2201
xref: UnificationXref2202
pathway order: PathwayStep313
pathway order: PathwayStep316
pathway order: PathwayStep318
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref554
type: RelationshipXref
id: GO:0004827
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref555
type: RelationshipXref
id: 4234920
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234920

http://identifiers.org/pubmed/17891149
type: PublicationXref
id: 17891149
author: Fasshauer, D
author: Riedel, D
author: Jahn, R
author: Radhakrishnan, A
author: Stein, A
db: Pubmed
title: Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids
source: Nat Struct Mol Biol 14:904-11
year: 2007

UniProt:P65760
type: ProteinReference
xref: UnificationXref423
organism: BioSource1

UniProt:P63966
type: ProteinReference
xref: UnificationXref136
organism: BioSource1

RelationshipXref547
type: RelationshipXref
id: 4234928
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234928

RelationshipXref548
type: RelationshipXref
id: GO:0004824
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref549
type: RelationshipXref
id: 4234959
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234959

RelationshipXref543
type: RelationshipXref
id: GO:0004818
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref544
type: RelationshipXref
id: 4234938
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234938

RelationshipXref545
type: RelationshipXref
id: 4234969
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234969

RelationshipXref546
type: RelationshipXref
id: GO:0004823
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref540
type: RelationshipXref
id: GO:0006418
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref541
type: RelationshipXref
id: GO:0004815
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref542
type: RelationshipXref
id: 4234949
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234949

http://identifiers.org/pubmed/19647993
type: PublicationXref
id: 19647993
author: Shental-Bechor, D
author: Levy, Y
db: Pubmed
title: Folding of glycoproteins: toward understanding the biophysics of the glycosylation code
source: Curr Opin Struct Biol 19:524-33
year: 2009

http://identifiers.org/pubmed/19501527
type: PublicationXref
id: 19501527
author: Cassel, SL
author: Sutterwala, FS
author: Joly, S
db: Pubmed
title: The NLRP3 inflammasome: a sensor of immune danger signals
source: Semin Immunol 21:194-8
year: 2009

RelationshipXref538
type: RelationshipXref
id: GO:0004832
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref539
type: RelationshipXref
id: 4234898
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234898

RelationshipXref536
type: RelationshipXref
id: GO:0004820
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref537
type: RelationshipXref
id: 4234904
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234904

RelationshipXref534
type: RelationshipXref
id: GO:0030168
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref535
type: RelationshipXref
id: GO:0007596
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref532
type: RelationshipXref
id: 4235054
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235054

RelationshipXref533
type: RelationshipXref
id: 4235078
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235078

RelationshipXref530
type: RelationshipXref
id: GO:0007268
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref531
type: RelationshipXref
id: GO:0005388
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref451
type: UnificationXref
id: 4234328
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234328

UnificationXref450
type: UnificationXref
id: 4234327
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234327

UnificationXref453
type: UnificationXref
id: 4233905
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233905

UnificationXref452
type: UnificationXref
id: REACT_159369
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159369.3

http://identifiers.org/pubmed/10745013
type: PublicationXref
id: 10745013
author: Gover, S
author: Lam, VM
author: Au, SW
author: Adams, MJ
db: Pubmed
title: Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP(+) molecule and provides insights into enzyme deficiency
source: Structure 8:293-303
year: 2000

http://identifiers.org/pubmed/8207089
type: PublicationXref
id: 8207089
author: Trueb, B
author: Koch, M
author: Odermatt, BF
author: Chiquet, M
author: Wälchli, C
db: Pubmed
title: Tissue-specific expression of the fibril-associated collagens XII and XIV
source: J Cell Sci 107:669-81
year: 1994

UnificationXref443
type: UnificationXref
id: REACT_2628
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2628.2

UnificationXref444
type: UnificationXref
id: P65232
db: UniProt

UnificationXref445
type: UnificationXref
id: 4233903
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233903

UnificationXref446
type: UnificationXref
id: 4233904
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233904

UnificationXref447
type: UnificationXref
id: 4234326
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234326

UnificationXref448
type: UnificationXref
id: 29372
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372

UnificationXref449
type: UnificationXref
id: REACT_2728
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2728.2

UnificationXref442
type: UnificationXref
id: 73566
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73566

UnificationXref441
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Downstream signaling of activated FGFR
type: Pathway
data source: Provenance1
pathway component: REACT 113517.8
evidence: Evidence500
xref: UnificationXref3515
xref: UnificationXref3514
pathway order: PathwayStep494
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref440
type: UnificationXref
id: REACT_3275
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3275.2

UniProt:P65788
type: ProteinReference
xref: UnificationXref2638
organism: BioSource1

3-Oxododecanoyl-CoA
type: SmallMoleculeReference
name: 3-Oxododecanoyl-CoA [ChEBI:27868]
xref: UnificationXref846

UnificationXref434
type: UnificationXref
id: REACT_4214
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4214.2

UnificationXref435
type: UnificationXref
id: CHEBI:16284
db: ChEBI

UnificationXref432
type: UnificationXref
id: CHEBI:17797
db: ChEBI

UnificationXref433
type: UnificationXref
id: 73578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73578

UnificationXref438
type: UnificationXref
id: CHEBI:17713
db: ChEBI

UnificationXref439
type: UnificationXref
id: 109386
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109386

UnificationXref436
type: UnificationXref
id: 110644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110644

UnificationXref437
type: UnificationXref
id: REACT_5673
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5673.1

UnificationXref473
type: UnificationXref
id: 4236262
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236262

UnificationXref472
type: UnificationXref
id: REACT_32751
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32751.10

UnificationXref475
type: UnificationXref
id: GO:0043202
db: GENE ONTOLOGY

UnificationXref474
type: UnificationXref
id: REACT_165871
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_165871.1

UnificationXref471
type: UnificationXref
id: 4235086
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235086

UnificationXref470
type: UnificationXref
id: 4235084
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235084

http://identifiers.org/pubmed/18690016
type: PublicationXref
id: 18690016
author: Schnetkamp, PP
author: Altimimi, HF
db: Pubmed
title: Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles
source: Channels (Austin) 1:62-9
year: 2007

http://identifiers.org/pubmed/12473340
type: PublicationXref
id: 12473340
author: Dyson, NJ
author: Stevaux, O
db: Pubmed
title: A revised picture of the E2F transcriptional network and RB function.
source: Curr Opin Cell Biol 14:684-91
year: 2002

UnificationXref469
type: UnificationXref
id: 4235083
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235083

UnificationXref465
type: UnificationXref
id: REACT_7206
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7206.3

UnificationXref466
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

UnificationXref467
type: UnificationXref
id: P71997
db: UniProt

UnificationXref468
type: UnificationXref
id: 4235082
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235082

UnificationXref464
type: UnificationXref
id: 174375
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174375

UnificationXref463
type: UnificationXref
id: REACT_19653
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19653.2

UnificationXref462
type: UnificationXref
id: 427648
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=427648

UnificationXref461
type: UnificationXref
id: CHEBI:16189
db: ChEBI

UnificationXref460
type: UnificationXref
id: REACT_13894
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13894.1

Pb
type: SmallMoleculeReference
name: ChEBI:6397 Pb2+
name: Lead
name: Pb2+
xref: UnificationXref3040

UnificationXref458
type: UnificationXref
id: GO:0005576
db: GENE ONTOLOGY

UnificationXref459
type: UnificationXref
id: 351626
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=351626

UnificationXref456
type: UnificationXref
id: 4236090
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236090

UnificationXref457
type: UnificationXref
id: REACT_155148
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155148.3

UnificationXref454
type: UnificationXref
id: 4233907
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233907

http://identifiers.org/pubmed/15265857
type: PublicationXref
id: 15265857
author: Lombardo, D
author: Aubert-Jousset, E
author: Sbarra, V
db: Pubmed
title: Site-directed mutagenesis of the distal basic cluster of pancreatic bile salt-dependent lipase
source: J Biol Chem 279:39697-704
year: 2004

http://identifiers.org/pubmed/19136672
type: PublicationXref
id: 19136672
author: Soslowsky, Louis J
author: Klement, John F
author: Koch, Manuel
author: Birk, David E
author: Beason, David P
author: Veit, Guido
author: Zhang, Guiyun
author: Meng, Xianmin
author: Ansorge, Heather L
author: Sun, Mei
db: Pubmed
title: Type XIV Collagen Regulates Fibrillogenesis: PREMATURE COLLAGEN FIBRIL GROWTH AND TISSUE DYSFUNCTION IN NULL MICE
source: J. Biol. Chem. 284:8427-38
year: 2009

UnificationXref455
type: UnificationXref
id: REACT_159064
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159064.3

Lagging Strand Synthesis
type: Pathway
data source: Provenance1
pathway component: Processive synthesis on the lagging strand
evidence: Evidence8
xref: UnificationXref33
xref: UnificationXref32
pathway order: PathwayStep7
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10940339
type: PublicationXref
id: 10940339
author: Laurell, H
author: Holm, C
author: Osterlund, T
author: Contreras, JA
db: Pubmed
title: Molecular mechanisms regulating hormone-sensitive lipase and lipolysis
source: Annu Rev Nutr 20:365-93
year: 2000

UnificationXref400
type: UnificationXref
id: 4233599
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233599

UnificationXref402
type: UnificationXref
id: 4233601
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233601

UnificationXref401
type: UnificationXref
id: 4233600
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233600

UnificationXref404
type: UnificationXref
id: REACT_29982
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29982.10

UnificationXref403
type: UnificationXref
id: 4233603
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233603

UnificationXref406
type: UnificationXref
id: 29996
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29996

http://identifiers.org/pubmed/10647174
type: PublicationXref
id: 10647174
author: Barker, PD
author: Ferguson, SJ
db: Pubmed
title: Still a puzzle: why is haem covalently attached in c-type cytochromes?
source: Structure Fold Des 7:R281-90
year: 1999

UnificationXref405
type: UnificationXref
id: CHEBI:16863
db: ChEBI

UnificationXref408
type: UnificationXref
id: P63338
db: UniProt

UnificationXref407
type: UnificationXref
id: REACT_2623
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2623.2

http://identifiers.org/pubmed/17916383
type: PublicationXref
id: 17916383
author: Turunen, M
author: Swiezewska, E
author: Chojnacki, T
author: Dallner, G
author: Tekle, M
db: Pubmed
title: Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells
source: J Biochem Biophys Methods 70:909-17
year: 2008

UnificationXref409
type: UnificationXref
id: 4233842
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233842

http://identifiers.org/pubmed/22921888
type: PublicationXref
id: 22921888
author: Davis, Margaret R
author: Summers, Kim M
db: Pubmed
title: Structure and function of the mammalian fibrillin gene family: Implications for human connective tissue diseases
source: Mol. Genet. Metab.
year: 2012

http://identifiers.org/pubmed/11500374
type: PublicationXref
id: 11500374
author: Ibberson, M
author: Horisberger, JD
author: Thorens, B
author: Uldry, M
author: Riederer, BM
author: Chatton, JY
db: Pubmed
title: Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain
source: EMBO J 20:4467-77
year: 2001

UniProt:P96907
type: ProteinReference
xref: UnificationXref947
organism: BioSource1

RelationshipXref495
type: RelationshipXref
id: GO:0003839
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref496
type: RelationshipXref
id: 4235438
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235438

UnificationXref430
type: UnificationXref
id: 4236063
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236063

RelationshipXref497
type: RelationshipXref
id: GO:0006750
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref431
type: UnificationXref
id: REACT_88984
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88984.9

RelationshipXref498
type: RelationshipXref
id: GO:1901687
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref499
type: RelationshipXref
id: GO:0008559
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref426
type: UnificationXref
id: 4233856
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233856

UnificationXref425
type: UnificationXref
id: 4233854
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233854

UnificationXref428
type: UnificationXref
id: 4234773
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234773

RelationshipXref490
type: RelationshipXref
id: GO:0004060
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref427
type: UnificationXref
id: REACT_88833
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88833.9

UnificationXref422
type: UnificationXref
id: REACT_3046
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3046.2

RelationshipXref492
type: RelationshipXref
id: GO:0016206
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref421
type: UnificationXref
id: 29790
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29790

RelationshipXref491
type: RelationshipXref
id: 4234505
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234505

O5-galactosyl-L-hydroxylysine
type: SequenceModificationVocabulary
xref: UnificationXref3932

UnificationXref424
type: UnificationXref
id: 4233853
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233853

RelationshipXref494
type: RelationshipXref
id: GO:0032259
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref423
type: UnificationXref
id: P65760
db: UniProt

RelationshipXref493
type: RelationshipXref
id: 4234511
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234511

UniProt:P96910
type: ProteinReference
xref: UnificationXref366
organism: BioSource1

UnificationXref429
type: UnificationXref
id: REACT_80876
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80876.9

UnificationXref420
type: UnificationXref
id: CHEBI:16332
db: ChEBI

http://identifiers.org/pubmed/12730128
type: PublicationXref
id: 12730128
author: Visse, R
author: Nagase, H
db: Pubmed
title: Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry
source: Circ Res 92:827-39
year: 2003

UnificationXref417
type: UnificationXref
id: 4233848
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233848

UnificationXref416
type: UnificationXref
id: 4233847
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233847

UnificationXref415
type: UnificationXref
id: Q79FJ2
db: UniProt

UnificationXref414
type: UnificationXref
id: REACT_3483
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3483.2

UnificationXref413
type: UnificationXref
id: 29732
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29732

UnificationXref412
type: UnificationXref
id: CHEBI:17363
db: ChEBI

UnificationXref411
type: UnificationXref
id: REACT_89152
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89152.9

UnificationXref410
type: UnificationXref
id: 4233844
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233844

UnificationXref419
type: UnificationXref
id: REACT_104383
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104383.9

Integration of energy metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 31270.10
evidence: Evidence263
xref: RelationshipXref234
xref: UnificationXref1749
xref: UnificationXref1750
pathway order: PathwayStep260
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref418
type: UnificationXref
id: 4233850
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233850

UniProt:P57689
type: ProteinReference
xref: UnificationXref2081
organism: BioSource1

http://identifiers.org/pubmed/7902568
type: PublicationXref
id: 7902568
author: Hopkinson, DA
author: March, RE
author: Whitehouse, DB
author: Edwards, YH
author: Ives, JH
author: Lovegrove, JU
author: Hollyoake, M
author: Putt, W
db: Pubmed
title: The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination
source: Proc Natl Acad Sci U S A 90:10730-3
year: 1993

http://identifiers.org/pubmed/9177788
type: PublicationXref
id: 9177788
author: Reiter, L T
author: Lupski, J R
author: Murakami, T
db: Pubmed
title: Genomic structure and expression of the human heme A:farnesyltransferase (COX10) gene
source: Genomics 42:161-4
year: 1997

cobalamin(III)
type: SmallMoleculeReference
name: cob(III)alamin [ChEBI:28911]
name: alpha-(5,6-dimethylbenzimidazolyl)cobamide
name: Cobalamin (III)
name: cobalamin(1+)
name: cob(III)alamin
name: Cbl
xref: UnificationXref2440

Degradation of collagen
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction333
evidence: Evidence594
xref: UnificationXref4119
xref: RelationshipXref564
xref: UnificationXref4118
pathway order: PathwayStep581
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/18434308
type: PublicationXref
id: 18434308
author: Moreland, NJ
author: Baker, EN
author: Bashiri, G
author: Squire, CJ
db: Pubmed
title: Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding
source: J Biol Chem 283:17531-41
year: 2008

http://identifiers.org/pubmed/10092594
type: PublicationXref
id: 10092594
author: Jones, JM
author: Gould, SJ
author: Geraghty, MT
author: Nau, K
author: Erdmann, R
db: Pubmed
title: Identification of peroxisomal acyl-CoA thioesterases in yeast and humans
source: J Biol Chem 274:9216-23
year: 1999

http://identifiers.org/pubmed/20185591
type: PublicationXref
id: 20185591
author: Green, Ralph
db: Pubmed
title: Ins and outs of cellular cobalamin transport
source: Blood 115:1476-7
year: 2010

http://identifiers.org/pubmed/11060359
type: PublicationXref
id: 11060359
author: Ferdinandusse, S
author: Denis, S
author: Waterham, HR
author: IJlst, L
author: Wanders, RJ
author: Dacremont, G
db: Pubmed
title: Subcellular localization and physiological role of alpha-methylacyl-CoA racemase
source: J Lipid Res 41:1890-6
year: 2000

http://identifiers.org/pubmed/12471035
type: PublicationXref
id: 12471035
author: Parolin, DA
author: Kelly, JF
author: Lavictoire, SJ
author: Lorimer, IA
author: Klimowicz, AC
db: Pubmed
title: Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII
source: J Biol Chem 278:5292-9
year: 2003

http://identifiers.org/pubmed/20576942
type: PublicationXref
id: 20576942
author: Kühl, Michael
author: Rao, Tata Purushothama
db: Pubmed
title: An updated overview on Wnt signaling pathways: a prelude for more
source: Circ. Res. 106:1798-806
year: 2010

trans-Hexadec-2-enoyl-CoA
type: SmallMoleculeReference
name: trans-2-Hexadecenoyl-CoA
name: trans-Hexadec-2-enoyl-CoA [ChEBI:28935]
xref: UnificationXref770

http://identifiers.org/pubmed/11060344
type: PublicationXref
id: 11060344
author: De Nys, K
author: Van Veldhoven, PP
author: Fransen, M
author: Mannaerts, GP
author: Amery, L
db: Pubmed
title: Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans
source: J Lipid Res 41:1752-9
year: 2000

NH4+
type: SmallMoleculeReference
name: NH4+ [ChEBI:28938]
xref: UnificationXref2047

http://identifiers.org/pubmed/8617364
type: PublicationXref
id: 8617364
author: Sakai, L Y
author: Pfaff, M
author: Timpl, R
author: Reinhardt, D P
db: Pubmed
title: Cell adhesion and integrin binding to recombinant human fibrillin-1
source: FEBS Lett. 384:247-50
year: 1996

http://identifiers.org/pubmed/10749848
type: PublicationXref
id: 10749848
author: Steinberg, SJ
author: Cuebas, DA
author: Kim, DG
author: Mihalik, SJ
author: Watkins, PA
db: Pubmed
title: The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase
source: J Biol Chem 275:15605-8
year: 2000

UnificationXref489
type: UnificationXref
id: REACT_135504
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135504.5

UnificationXref488
type: UnificationXref
id: 4235601
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235601

UnificationXref487
type: UnificationXref
id: 4235599
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235599

http://identifiers.org/pubmed/16380219
type: PublicationXref
id: 16380219
author: Dean, NM
author: Koo, S
author: Kang, X
author: Kim, Y
author: White, N
author: Marcusson, EG
author: Perera, RJ
db: Pubmed
title: Identification of novel PPARgamma target genes in primary human adipocytes
source: Gene 369:90-9
year: 2006

UnificationXref492
type: UnificationXref
id: REACT_125104
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125104.1

UnificationXref493
type: UnificationXref
id: CHEBI:63811
db: ChEBI

UnificationXref490
type: UnificationXref
id: CHEBI:63810
db: ChEBI

UnificationXref491
type: UnificationXref
id: 2090070
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2090070

UnificationXref496
type: UnificationXref
id: 4235773
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235773

UnificationXref497
type: UnificationXref
id: REACT_137970
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137970.5

UnificationXref494
type: UnificationXref
id: 2090045
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2090045

UnificationXref495
type: UnificationXref
id: REACT_123208
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123208.1

UnificationXref477
type: UnificationXref
id: 2090072
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2090072

UnificationXref476
type: UnificationXref
id: CHEBI:63805
db: ChEBI

UnificationXref479
type: UnificationXref
id: 1605715
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1605715

UnificationXref478
type: UnificationXref
id: REACT_121472
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121472.1

Rv1079
type: ProteinReference
name: metB
name: MTV017.32
name: UniProt:P66875
name: MT1110
xref: UnificationXref2984
comment: CATALYTIC ACTIVITY: O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate.
organism: BioSource1

UnificationXref480
type: UnificationXref
id: REACT_117033
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117033.1

UnificationXref481
type: UnificationXref
id: CHEBI:63806
db: ChEBI

UnificationXref482
type: UnificationXref
id: 2090040
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2090040

UnificationXref483
type: UnificationXref
id: REACT_125281
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125281.1

UnificationXref484
type: UnificationXref
id: 1606845
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1606845

UnificationXref485
type: UnificationXref
id: REACT_116559
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116559.2

UnificationXref486
type: UnificationXref
id: Q6MX51
db: UniProt

http://identifiers.org/pubmed/12438653
type: PublicationXref
id: 12438653
author: Rosenblatt, DS
author: Wilson, Aaron
author: Leclerc, Daniel
author: Doré, Carole
author: Wu, Xuchu
author: Hudson, Thomas
author: Dobson, C Melissa
author: Gravel, RA
author: Wai, Timothy
db: Pubmed
title: Identification of the gene responsible for the cblA complementation group of vitamin B12-responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements
source: Proc. Natl. Acad. Sci. U.S.A. 99:15554-9
year: 2002

UnificationXref1899
type: UnificationXref
id: REACT_139904
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139904.5

UnificationXref1898
type: UnificationXref
id: 4233974
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233974

UnificationXref1897
type: UnificationXref
id: 4233972
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233972

UnificationXref1892
type: UnificationXref
id: REACT_95189
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95189.9

UnificationXref1891
type: UnificationXref
id: 4233976
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233976

UnificationXref1890
type: UnificationXref
id: REACT_3964
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3964.3

UnificationXref1896
type: UnificationXref
id: P65902
db: UniProt

UnificationXref1895
type: UnificationXref
id: REACT_2513
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2513.2

http://identifiers.org/pubmed/11175906
type: PublicationXref
id: 11175906
author: Burden, A
author: Wu, CK
author: Wang, BC
author: Dailey, HA
author: Rose, JP
author: Sellers, VM
db: Pubmed
title: The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis.
source: Nat Struct Biol 8:156-60
year: 2001

UnificationXref1894
type: UnificationXref
id: 111369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111369

UnificationXref1893
type: UnificationXref
id: CHEBI:18413
db: ChEBI

2,4-Dinitro-1-chlorobenzene
type: SmallMoleculeReference
name: 1-chloro-2,4-dinitrobenzene [ChEBI:34718]
name: DNCB
name: 1-Chloro-2,4-dinitrobenzol
name: 1-chloro-2,4-dinitrobenzene
name: Dncb
name: 6-Chloro-1,3-dinitrobenzene
name: Dinitrochlorobenzene
name: 1,3-Dinitro-4-chlorobenzene
name: Chlorodinitrobenzene
name: 2,4-Dinitrophenyl chloride
name: Cdnb
name: 4-Chloro-1,3-dinitrobenzene
name: 2,4-Dinitrochlorobenzene
xref: UnificationXref3647

UnificationXref499
type: UnificationXref
id: REACT_140112
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140112.5

http://identifiers.org/pubmed/5046811
type: PublicationXref
id: 5046811
author: Kishida, Y
author: Prockop, DJ
author: Kivirikko, KI
author: Sakakibara, S
db: Pubmed
title: Hydroxylation of (X-Pro-Gly)n by protocollagen proline hydroxylase. Effect of chain length, helical conformation and amino acid sequence in the substrate
source: Biochim Biophys Acta 271:347-56
year: 1972

http://identifiers.org/pubmed/9278091
type: PublicationXref
id: 9278091
author: Hildebrandt, JD
db: Pubmed
title: Role of subunit diversity in signaling by heterotrimeric G proteins
source: Biochem Pharmacol 54:325-39
year: 1997

UnificationXref498
type: UnificationXref
id: 4236338
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236338

http://identifiers.org/pubmed/10745006
type: PublicationXref
id: 10745006
author: Chuang, JL
author: Turley, S
author: Chuang, DT
author: Aevarsson, A
author: Wynn, RM
author: Hol, WG
db: Pubmed
title: Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease.
source: Structure Fold Des 8:277-91
year: 2000

UnificationXref1887
type: UnificationXref
id: REACT_3395
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3395.2

UnificationXref1886
type: UnificationXref
id: 111354
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111354

UnificationXref1889
type: UnificationXref
id: 111355
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111355

UnificationXref1888
type: UnificationXref
id: CHEBI:15635
db: ChEBI

http://identifiers.org/pubmed/8307007
type: PublicationXref
id: 8307007
author: Proudfoot, AE
author: Wells, TN
author: Turcatti, G
author: Smith, DJ
author: Payton, MA
db: Pubmed
title: Purification, cDNA cloning and heterologous expression of human phosphomannose isomerase
source: Eur J Biochem 219:415-23
year: 1994

http://identifiers.org/pubmed/10959839
type: PublicationXref
id: 10959839
author: Tomkinson, AE
author: McKenna, AE
author: Matsumoto, Y
author: Motycka, TA
author: Levin, DS
db: Pubmed
title: Interaction between PCNA and DNA ligase I is critical for joining of Okazaki fragments and long-patch base-excision repair.
source: Curr Biol 10:919-22
year: 2000

UnificationXref1881
type: UnificationXref
id: REACT_99517
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99517.9

http://identifiers.org/pubmed/15588825
type: PublicationXref
id: 15588825
author: Kadler, KE
author: Holmes, DF
db: Pubmed
title: The precision of lateral size control in the assembly of corneal collagen fibrils
source: J Mol Biol 345:773-84
year: 2005

UnificationXref1880
type: UnificationXref
id: 4233978
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233978

UnificationXref1883
type: UnificationXref
id: 419151
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=419151

UnificationXref1882
type: UnificationXref
id: CHEBI:15637
db: ChEBI

UnificationXref1885
type: UnificationXref
id: CHEBI:18272
db: ChEBI

UnificationXref1884
type: UnificationXref
id: REACT_18590
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18590.3

O06401
type: Protein
entity reference: O06401
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2888
feature: FragmentFeature248
cellular location: GO:0005622
comment: Reactome DB_ID: 4235424
display name: MTAP

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P57689
data source: Provenance1
name: P57689
name: carbamoyl-phosphate synthase (ammonia), mitochondrial
name: carbamoyl-phosphate synthetase I
name: CPSase I
xref: UnificationXref2834
feature: FragmentFeature244
cellular location: GO:0005622
comment: Reactome DB_ID: 4233660
display name: CPS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A5M8
data source: Provenance1
name: P0A5M8
name: ornithine transcarbamylase
name: ornithine carbamoyltransferase, mitochondrial
xref: UnificationXref2847
feature: FragmentFeature245
cellular location: GO:0005622
comment: Reactome DB_ID: 4233668
display name: OTC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P63642
data source: Provenance1
name: argininosuccinic acid synthetase
name: Citrulline--aspartate ligase
name: P63642
name: citrulline-aspartate ligase
name: argininosuccinate synthase
xref: UnificationXref2857
feature: FragmentFeature246
cellular location: GO:0005622
comment: Reactome DB_ID: 4233680
display name: ASS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A4Z0
data source: Provenance1
name: P0A4Z0
name: arginosuccinase
name: argininosuccinate lyase
xref: UnificationXref2865
feature: FragmentFeature247
cellular location: GO:0005622
comment: Reactome DB_ID: 4233674
display name: ASL

ATTY_HUMAN
type: Protein
entity reference: P63498
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Tyrosine aminotransferase
name: L-tyrosine:2-oxoglutarate aminotransferase
name: tyrosine aminotransferase
name: P63498
name: PXLP-TAT
xref: UnificationXref2814
feature: ModificationFeature46
feature: FragmentFeature241
cellular location: GO:0005622
comment: Reactome DB_ID: 4233824
display name: TAT

PUT2_HUMAN
type: Protein
entity reference: O50443
data source: Provenance1
name: P5C dehydrogenase monomer
name: Note: the coordinates are copied over from Homo sapiens.
name: delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
name: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor
name: P5C dehydrogenase
name: ALDH4A1
xref: UnificationXref2823
feature: FragmentFeature242
cellular location: GO:0005622
comment: Reactome DB_ID: 4233705
display name: O50443

Homologues of CPS1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P71811
xref: UnificationXref2835
cellular location: GO:0005622
comment: Reactome DB_ID: 4233661
comment: Converted from EntitySet in Reactome

P71811
type: Protein
entity reference: P71811
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: carbamoyl-phosphate synthase (ammonia), mitochondrial
name: carbamoyl-phosphate synthetase I
name: CPSase I
xref: UnificationXref2833
feature: FragmentFeature243
cellular location: GO:0005622
comment: Reactome DB_ID: 4233657
display name: CPS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P95208
data source: Provenance1
name: glutaryl-CoA dehydrogenase
name: Glutaryl-CoA dehydrogenase, mitochondrial
name: P95208
xref: UnificationXref2801
feature: FragmentFeature240
cellular location: GO:0005622
comment: Reactome DB_ID: 4233817
display name: GCDH

eNOS activation and regulation
type: Pathway
data source: Provenance1
pathway component: REACT 133722.5
evidence: Evidence266
xref: UnificationXref1770
xref: RelationshipXref237
xref: UnificationXref1771
pathway order: PathwayStep263
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/9802883
type: PublicationXref
id: 9802883
author: Davis, DL
author: Russell, DW
author: Thompson, HR
author: Lathe, R
author: Sokol, RJ
author: Setchell, KD
author: O'Connell, NC
author: Lund, EG
author: Weslie Tyson, R
author: Schwarz, M
db: Pubmed
title: Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease
source: J Clin Invest 102:1690-703
year: 1998

http://identifiers.org/pubmed/9536209
type: PublicationXref
id: 9536209
author: Clarke, D
author: Cunningham, SK
author: Fearon, U
author: McKenna, TJ
db: Pubmed
title: A critical review of the origin and control of adrenal androgens
source: Baillieres Clin Obstet Gynaecol 11:229-48
year: 1997

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53816
data source: Provenance1
name: methylmalonate semialdehyde dehydrogenase, monomer
name: ALDH6A1
name: Methylmalonate-semialdehyde dehydrogenase (acylating) (EC 1.2.1.27) (MMSDH)
name: O53816
xref: UnificationXref2779
feature: FragmentFeature238
cellular location: GO:0005622
comment: Reactome DB_ID: 4233782
display name: MMSDH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7D5R7
data source: Provenance1
name: ALDH7A1
name: Alpha-aminoadipic semialdehyde dehydrogenase
name: antiquitin
xref: UnificationXref2791
feature: FragmentFeature239
cellular location: GO:0005622
comment: Reactome DB_ID: 4233787
display name: Q7D5R7

http://identifiers.org/pubmed/15994327
type: PublicationXref
id: 15994327
author: Oram, JF
author: Vaughan, AM
db: Pubmed
title: ABCG1 redistributes cellular cholesterol to domains removable by high density lipoproteins but not by lipid-depleted lipoproteins
source: J Biol Chem 280:30150-30157
year: 2005

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53419
data source: Provenance1
name: HIBCH(32-386)
name: 3-hydroxyisobutyryl-coenzyme A hydrolase
xref: UnificationXref2765
feature: FragmentFeature236
cellular location: GO:0005622
comment: Reactome DB_ID: 4233771
display name: O53419

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P63935
data source: Provenance1
name: 3-hydroxyisobutyrate dehydrogenase, monomer
name: P63935
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor
name: D3HI_HUMAN
xref: UnificationXref2772
feature: FragmentFeature237
cellular location: GO:0005622
comment: Reactome DB_ID: 4233776
display name: HIBADH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O06544
data source: Provenance1
name: HSD17B10
name: 2-methyl-3-hydroxybutyryl-CoA dehydrogenase
name: 3-hydroxyacyl-CoA dehydrogenase type II
name: Endoplasmic reticulum-associated amyloid beta-peptide binding protein
name: O06544
name: endoplasmic reticulum-associated amyloid beta-peptide binding protein
xref: UnificationXref2740
feature: FragmentFeature234
cellular location: GO:0005622
comment: Reactome DB_ID: 4233753
display name: HADH2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53815
data source: Provenance1
name: ARC42
name: O53815
name: acyl-CoA dehydrogenase family member 8
name: Acyl-CoA dehydrogenase family member 8, mitochondrial precursor
name: Activator- recruited cofactor 42 kDa component
name: isobutyryl-CoA dehydrogenase
name: ACAD8(24-415)
xref: UnificationXref2754
feature: FragmentFeature235
cellular location: GO:0005622
comment: Reactome DB_ID: 4233765
display name: ACAD8

IVD_HUMAN
type: Protein
entity reference: O33331
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: O33331
name: isovaleryl-CoA dehydrogenase, apoenzyme
name: Isovaleryl-CoA dehydrogenase, mitochondrial precursor
xref: UnificationXref2713
feature: FragmentFeature232
cellular location: GO:0005622
comment: Reactome DB_ID: 4233726
display name: IVD

2-MEBCAD
type: Protein
entity reference: O06164
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: acyl-CoA dehydrogenase, short/branched chain specific
name: ACADSB
name: ACADSB(52-432)
name: O06164
name: Acyl-CoA dehydrogenase, short/branched chain specific, mitochondrial precursor
name: 2-methylbutyryl-CoA dehydrogenase
name: 2-methyl branched chain acyl-CoA dehydrogenase
name: 2-methylbutyryl-coenzyme A dehydrogenase
name: Acyl-CoA dehydrogenase, short/branched chain specific, mitochondrial precursor (EC 1.3.99.-) (SBCAD) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase)
xref: UnificationXref2729
feature: FragmentFeature233
cellular location: GO:0005622
comment: Reactome DB_ID: 4233747
display name: SBCAD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O06160
data source: Provenance1
name: O06160
name: branched chain keto acid dehydrogenase E1, beta polypeptide
xref: UnificationXref2697
feature: FragmentFeature230
cellular location: GO:0005622
comment: Reactome DB_ID: 4233714
display name: BCKDHB

Glycine cleavage system L protein
type: Protein
entity reference: P66004
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P66004
name: Dihydrolipoamide dehydrogenase, mitochondrial
xref: UnificationXref2703
feature: FragmentFeature231
cellular location: GO:0005622
comment: Reactome DB_ID: 4233717
display name: DLD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P71890
data source: Provenance1
name: ornithine-oxo-acid aminotransferase
name: PXLP-OAT(26-439)
name: P71890
name: ornithine aminotransferase, mitochondrial
xref: UnificationXref2629
feature: FragmentFeature223
feature: ModificationFeature44
cellular location: GO:0005622
comment: Reactome DB_ID: 4233693
display name: OAT

http://identifiers.org/pubmed/17088555
type: PublicationXref
id: 17088555
author: Kadler, Karl E
author: Holmes, David F
db: Pubmed
title: The 10+4 microfibril structure of thin cartilage fibrils
source: Proc. Natl. Acad. Sci. U.S.A. 103:17249-54
year: 2006

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P71891
data source: Provenance1
name: ornithine-oxo-acid aminotransferase
name: PXLP-OAT(26-439)
name: P71891
name: ornithine aminotransferase, mitochondrial
xref: UnificationXref2631
feature: ModificationFeature45
feature: FragmentFeature224
cellular location: GO:0005622
comment: Reactome DB_ID: 4233697
display name: OAT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P65788
data source: Provenance1
name: ALDH18A1-1
name: ALDH18A1 long
name: P5CS long
name: Delta-1-pyrroline-5-carboxylate synthetase long
name: ALDH18A1 isoform 1
xref: UnificationXref2639
feature: FragmentFeature225
cellular location: GO:0005622
comment: Reactome DB_ID: 4235179
display name: P65788

ALDH18A1-2
type: Protein
entity reference: UniProt:P65788
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ALDH18A1 short
name: Delta-1-pyrroline-5-carboxylate synthetase short
name: P5CS short
name: ALDH18A1 isoform 2
xref: UnificationXref2641
feature: FragmentFeature226
cellular location: GO:0005622
comment: Reactome DB_ID: 4235181
display name: P65788

D-3-phosphoglycerate dehydrogenase
type: Protein
entity reference: P0A544
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P0A544
name: PHGHD
name: SERA_HUMAN
xref: UnificationXref2656
feature: FragmentFeature227
cellular location: GO:0005622
comment: Reactome DB_ID: 4235398
display name: PHGDH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53289
data source: Provenance1
name: O53289
xref: UnificationXref2664
feature: FragmentFeature228
cellular location: GO:0005622
comment: Reactome DB_ID: 4235392
display name: PSPH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O06161
data source: Provenance1
name: branched chain keto acid dehydrogenase E1, alpha polypeptide
name: O06161
xref: UnificationXref2695
feature: FragmentFeature229
cellular location: GO:0005622
comment: Reactome DB_ID: 4233711
display name: BCKDHA

PublicationXref209
type: PublicationXref
id: 0079130356
author: Rosenblatt, DS
author: Fenton, WA
author: Gravel, RA
db: ISBN
title: Disorders of propionate and methylmalonate metabolism
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 2165-2193
year: 2001

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O05795
data source: Provenance1
name: O05795
name: MOCS2A
xref: UnificationXref2610
feature: FragmentFeature221
cellular location: GO:0005622
comment: Reactome DB_ID: 4235352
display name: MOCS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53878
data source: Provenance1
name: O53878
name: MOCS2A
xref: UnificationXref2611
feature: FragmentFeature222
cellular location: GO:0005622
comment: Reactome DB_ID: 4235355
display name: MOCS2

Homologues of PXLP-OAT(26-439)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2632
cellular location: GO:0005622
comment: Reactome DB_ID: 4233698
comment: Converted from EntitySet in Reactome

PublicationXref224
type: PublicationXref
id: 0716720094
author: Stryer, L
db: ISBN
title: 21: Oxidative Phosphorylation
source: Biochemistry, 4th ed (Book): 548-549
year: 1995

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O05786
data source: Provenance1
name: O05786
name: MOCS1-1
xref: UnificationXref2585
feature: FragmentFeature213
cellular location: GO:0005622
comment: Reactome DB_ID: 4235342
display name: MOCS1B

http://identifiers.org/pubmed/11980911
type: PublicationXref
id: 11980911
author: Steinberg, SJ
author: Heinzer, AK
author: Park, J
author: Cuebas, DA
author: Kim, DG
author: Smith, KD
author: Mihalik, SJ
author: Watkins, PA
author: Wanders, RJ
author: Dacremont, G
author: Pei, Z
db: Pubmed
title: Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling
source: J Biol Chem 277:24771-9
year: 2002

Homologues of MOCS2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2604
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4235367

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6MWY3
data source: Provenance1
name: MOCS2(1-188)
name: Q6MWY3
name: MOCS2B
xref: UnificationXref2601
feature: FragmentFeature217
cellular location: GO:0005622
comment: Reactome DB_ID: 4235364
display name: MOCS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O05795
data source: Provenance1
name: SOG-MOCS2
name: MOCS2A-CO-S(1-)
xref: UnificationXref2597
feature: ModificationFeature42
feature: FragmentFeature215
cellular location: GO:0005622
comment: Reactome DB_ID: 4235360
display name: O05795

Anchoring fibril formation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction331
pathway component: BiochemicalReaction330
evidence: Evidence588
xref: UnificationXref4085
xref: UnificationXref4086
pathway order: PathwayStep574
pathway order: PathwayStep575
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53878
data source: Provenance1
name: SOG-MOCS2
name: MOCS2A-CO-S(1-)
xref: UnificationXref2599
feature: FragmentFeature216
feature: ModificationFeature43
cellular location: GO:0005622
comment: Reactome DB_ID: 4235362
display name: O53878

Homologues of MOCS2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2612
cellular location: GO:0005622
comment: Reactome DB_ID: 4235356
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6MWY3
data source: Provenance1
name: Q6MWY3
name: MOCS2A
xref: UnificationXref2609
feature: FragmentFeature220
cellular location: GO:0005622
comment: Reactome DB_ID: 4235349
display name: MOCS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O05795
data source: Provenance1
name: MOCS2(1-188)
name: O05795
name: MOCS2B
xref: UnificationXref2602
feature: FragmentFeature218
cellular location: GO:0005622
comment: Reactome DB_ID: 4235365
display name: MOCS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53878
data source: Provenance1
name: MOCS2(1-188)
name: O53878
name: MOCS2B
xref: UnificationXref2603
feature: FragmentFeature219
cellular location: GO:0005622
comment: Reactome DB_ID: 4235366
display name: MOCS2

http://identifiers.org/pubmed/11279194
type: PublicationXref
id: 11279194
author: Orlowski, J
author: Numata, M
db: Pubmed
title: Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network
source: J Biol Chem 276:17387-94
year: 2001

Homologues of SOG-MOCS2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2600
cellular location: GO:0005622
comment: Reactome DB_ID: 4235363
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6MWY3
data source: Provenance1
name: SOG-MOCS2
name: MOCS2A-CO-S(1-)
xref: UnificationXref2595
feature: ModificationFeature41
feature: FragmentFeature214
cellular location: GO:0005622
comment: Reactome DB_ID: 4235358
display name: Q6MWY3

Evidence312
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18184586
xref: http://identifiers.org/pubmed/8631878
xref: http://identifiers.org/pubmed/6893554
xref: http://identifiers.org/pubmed/9042911
comment: The decarboxylation of orotidine 5'-monophosphate (OMP) to form uridine 5'-monophosphate (UMP) is catalyzed by the orotidine 5'-phosphate decarboxylase activity of the bifunctional "uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine 5'-decarboxylase)" protein. While purified human protein has not been characterized in detail, the close similarity of the human gene to that encoding the well-studied hamster protein, and the demonstration that mutations in the human gene are associated with failure to convert orotate to UMP in vivo, provide convincing evidence that the human uridine monophosphate synthetase protein indeed catalyzes these two reactions (McClard et al. 1980; Suchi et al. 1997). The active form of the human protein is a dimer (Yablonski et al. 1996; Wittmann et al. 2008).

Evidence313
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8631816
xref: http://identifiers.org/pubmed/8805593
comment: Deoxyuridine triphosphatase (DUT) catalyzes the hydrolysis of dUTP to form dUMP and pyrophosphate. Two isoforms of DUT are expressed, generated by alternative splicing. The major one, annotated here, is localized to the nucleoplasm (Ladner et al. 1996). The enzyme is a homotrimer (Mol et al. 1996). In the cell, this reaction depletes the supply of dUTP, preventing its incorporation into DNA, while generating dUMP, the immediate precursor of thymidine nucleotides.

http://identifiers.org/pubmed/11606068
type: PublicationXref
id: 11606068
author: Lorkowski, S
author: Rust, S
author: Engel, T
author: Berger, G
author: Assmann, G
author: Cullen, P
author: Lueken, A
author: Schlüter, B
db: Pubmed
title: The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages
source: Biochem Biophys Res Commun 288:483-8
year: 2001

Evidence314
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11278511
xref: http://identifiers.org/pubmed/2656695
comment: Cytosolic thymidylate synthase catalyzes the reaction of dUMP and N5,N10-methylene tetrahydrofolate to form TMP and dihydrofolate (Davisson et al. 1989). The enzyme is a homodimer (Phan et al. 2001).

Evidence315
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref461
xref: http://identifiers.org/pubmed/6105839
comment: The pyrimidine orotate (orotic acid) is synthesized in a sequence of four reactions, deriving its atoms from glutamine, bicarbonate, and aspartate. A single multifunctional cytosolic enzyme catalyzes the first three of these reactions, while the last one is catalyzed by an enzyme associated with the inner mitochondrial membrane. In two further reactions, catalyzed by a bifunctional cytosolic enzyme, orotate reacts with 1-phosphoribosyl 5-pyrophosphate (PRPP) to yield orotidine 5'-monophosphate, which is decarboxylated to yield uridine 5'-monophosphate (UMP). While several individual reactions in this pathway are reversible, other irreversible reactions drive the pathway in the direction of UMP biosynthesis in the normal cell. All reactions are thus annotated here only in the forward direction. This pathway has been most extensively analyzed at the genetic and biochemical level in hamster cell lines. All three enzymes have also been purified from human sources, however, and the key features of these reactions have been confirmed from studies of this human material (Jones 1980; Webster et al. 2001). All other pyrimidines are synthesized from UMP. The reactions annotaed here, catalyzed by dCMP deaminase and dUTP diphosphatase yield dUMP, which in turn is converted to TMP by thymidylate synthase.

UnificationXref1109
type: UnificationXref
id: 389636
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389636

UnificationXref1108
type: UnificationXref
id: CHEBI:49189
db: ChEBI

Evidence316
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/14725767
xref: http://identifiers.org/pubmed/7284378
xref: http://identifiers.org/pubmed/1590793
comment: Cytosolic thymidine phosphorylase (TYMP) catalyzes the reversible reactions of thymine or uracil with 2-deoxy-D-ribose 1-phosphate to form thymidine or deoxyuridine and orthiophosphate. The active form of the enzyme is a homodimer (Desgranges et al. 1981; Norman et al. 2004; Usuki et al. 1992).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q10641
data source: Provenance1
name: Nicotinate phosphoribosyltransferase
name: Q10641
xref: UnificationXref2498
feature: FragmentFeature205
cellular location: GO:0005622
comment: Reactome DB_ID: 4234671
display name: NAPRT1

UnificationXref1107
type: UnificationXref
id: REACT_17536
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17536.2

Evidence317
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15689149
xref: http://identifiers.org/pubmed/7923172
comment: Cytosolic cytidine deaminase catalyzes the hydrolysis of cytidine or dexoycytidine to form uridine or deoxyuridine and ammonia (Laliberte and Momparler 1994). The active form of the enzyme is a tetramer (Chung et al. 2005).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O53174
data source: Provenance1
name: Folylpolyglutamate synthase-2
name: FPGS isoform 2
name: O53174
name: FOLC_HUMAN
xref: UnificationXref2512
feature: FragmentFeature206
cellular location: GO:0005622
comment: Reactome DB_ID: 4234696
display name: FPGS-2

http://identifiers.org/pubmed/18073209
type: PublicationXref
id: 18073209
author: Barnes, Aileen M
author: McBride, Daniel J
author: Makareeva, Elena
author: Leikin, Sergey
author: Cabral, Wayne A
author: Mertz, Edward L
author: Marini, Joan C
author: Kuznetsova, Natalia V
author: DeRidder, Angela M
author: Sutter, Mary B
db: Pubmed
title: Structural heterogeneity of type I collagen triple helix and its role in osteogenesis imperfecta
source: J. Biol. Chem. 283:4787-98
year: 2008

UnificationXref1106
type: UnificationXref
id: 389578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389578

Evidence318
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref461
comment: In pyrimidine salvage reactions, nucleosides and free bases generated by DNA and RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathways of pyrimidine biosynthesis (interconversion).

UnificationXref1105
type: UnificationXref
id: CHEBI:15522
db: ChEBI

Evidence319
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/14725767
xref: http://identifiers.org/pubmed/7284378
xref: http://identifiers.org/pubmed/1590793
comment: Cytosolic thymidine phosphorylase (TYMP) catalyzes the reversible reactions of thymidine or deoxyuridine with orthophosphate to form thymine or uracil and 2-deoxy-D-ribose 1-phosphate. The active form of the enzyme is a homodimer (Desgranges et al. 1981; Norman et al. 2004; Usuki et al. 1992).

UnificationXref1104
type: UnificationXref
id: REACT_17914
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17914.2

UnificationXref1103
type: UnificationXref
id: 389594
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389594

UnificationXref1102
type: UnificationXref
id: CHEBI:15475
db: ChEBI

UnificationXref1101
type: UnificationXref
id: REACT_92899
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92899.9

UnificationXref1100
type: UnificationXref
id: 4234998
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234998

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O50385
data source: Provenance1
name: O50385
xref: UnificationXref2535
feature: FragmentFeature207
cellular location: GO:0005622
comment: Reactome DB_ID: 4234776
display name: MTHFD1

MOCS1-5
type: Protein
entity reference: O05786
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: O05786
xref: UnificationXref2582
feature: FragmentFeature211
cellular location: GO:0005622
comment: Reactome DB_ID: 4235339
display name: MOCS1A

MOCS1-5
type: Protein
entity reference: P65384
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P65384
xref: UnificationXref2580
feature: FragmentFeature210
cellular location: GO:0005622
comment: Reactome DB_ID: 4235336
display name: MOCS1A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P65384
data source: Provenance1
name: MOCS1-1
name: P65384
xref: UnificationXref2584
feature: FragmentFeature212
cellular location: GO:0005622
comment: Reactome DB_ID: 4235341
display name: MOCS1B

Homologues of MOCS1-1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2586
cellular location: GO:0005622
comment: Reactome DB_ID: 4235343
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53441
data source: Provenance1
name: serine hydroxymethyltransferase
name: PXLP-SHMT1(1-483)
name: O53441
name: glycine hydroxymethyltransferase
name: Serine methylase
xref: UnificationXref2553
feature: ModificationFeature39
feature: FragmentFeature208
cellular location: GO:0005622
comment: Reactome DB_ID: 4233831
display name: SHMT1

Homologues of PXLP-SHMT1(1-483)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2556
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4233836

Evidence311
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18184586
xref: http://identifiers.org/pubmed/8631878
xref: http://identifiers.org/pubmed/6893554
xref: http://identifiers.org/pubmed/9042911
comment: The synthesis of orotidine 5'-monophosphate (OMP) from orotate and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) is catalyzed by the orotate phosphoribosyltransferase activity of the bifunctional "uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine 5'-decarboxylase)" protein. The reaction itself is freely reversible, but is pulled in the forward direction in vivo by the irreversible hydrolysis of pyrophosphate. While purified human protein has not been characterized in detail, the close similarity of the human gene to that encoding the well-studied hamster protein, and the demonstration that mutations in the human gene are associated with failure to convert orotate to UMP in vivo, provide convincing evidence that the human uridine monophosphate synthetase protein indeed catalyzes these two reactions (McClard et al. 1980; Suchi et al. 1997). The active form of the human protein is a dimer (Yablonski et al. 1996; Wittmann et al. 2008).

Homologues of MOCS1A
type: Protein
data source: Provenance1
member physical entity: MOCS1-5
xref: UnificationXref2583
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4235340

Evidence310
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9693067
xref: http://identifiers.org/pubmed/6105839
xref: http://identifiers.org/pubmed/10889450
xref: http://identifiers.org/pubmed/13115431
xref: http://identifiers.org/pubmed/165196
comment: Dihydroorotate dehydrogenase catalyzes the oxidation of dihydroorotate to orotate (orotic acid). The enzyme is located in the inner mitochondrial membrane oriented so that cytosolic dihydroorotate molecules have access to it, and orotate is released into the cytosol. The reducing equivalents generated by the reaction are transferred by ubiquinone (Coenzyme Q) to the electron transport chain within the inner mitochondrial membrane. There is no evidence for the involvement of NAD+ as an acceptor of reducing equivalents in this reaction in mammalian cells (Jones 1980). In contrast, the reaction catalyzed by the enzyme isolated from the anaerobic bacterium Clostridium oroticum requires NAD+ as a cofactor but also proceeds strongly in the direction of dihydroorotate synthesis consistent with the greater electronegativity of NAD+ (Lieberman and Kornberg 1953). Early studies of purified rat liver enzyme by Forman and Kennedy suggested the presence of flavin mononucleotide and iron-sulfur complexes as cofactors. More recent work by Bader, Beuneu, and their colleagues with recombinant human protein expressed in insect cells has confirmed the presence of flavin mononucleotide, at a stoichiometry of one molecule per molecule of apoenzyme but suggests that iron-sulfur complexes, if indeed they are involved in the oxidation and electron transport process, are not an integral part of the dihydroorotate dehydrogenase holoenzyme.

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53615
data source: Provenance1
name: serine hydroxymethyltransferase
name: PXLP-SHMT1(1-483)
name: O53615
name: glycine hydroxymethyltransferase
name: Serine methylase
xref: UnificationXref2555
feature: ModificationFeature40
feature: FragmentFeature209
cellular location: GO:0005622
comment: Reactome DB_ID: 4233835
display name: SHMT1

Evidence303
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6771276
xref: http://identifiers.org/pubmed/2104852
xref: http://identifiers.org/pubmed/3029074
comment: Cytosolic nucleoside phosphorylase (NP) trimer catalyzes the reversible reaction of guanosine or deoxyguanosine with orthophosphate to form guanine and ribose 1-phosphate or deoxyribose 1-phosphate (Ealick et al. 1990; Wiginton et al. 1980). While NP is active with either nuckeotide in vitro, levels of deoxyguanosine are normally low in vivo, limiting the extent of this reaction. NP deficiency in vivo is associated with defects in purine nucleotide salvage and leads to immunodeficiency (Williams et al. 1987).

Evidence304
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6771276
xref: http://identifiers.org/pubmed/2104852
xref: http://identifiers.org/pubmed/3029074
comment: Cytosolic nucleoside phosphorylase (NP) trimer catalyzes the reversible reaction of inosine or deoxyinosine with orthophosphate to form hypoxanthine and ribose 1-phosphate or deoxyribose 1-phosphate (Ealick et al. 1990; Wiginton et al. 1980). While NP is active with either nuckeotide in vitro, levels of deoxyinosine are normally low in vivo, limiting the extent of this reaction. NP deficiency in vivo is associated with defects in purine nucleotide salvage and leads to immunodeficiency (Williams et al. 1987).

http://identifiers.org/pubmed/20060739
type: PublicationXref
id: 20060739
author: Sheftel, Alex
author: Stehling, Oliver
author: Lill, R
db: Pubmed
title: Iron-sulfur proteins in health and disease
source: Trends Endocrinol. Metab. 21:302-14
year: 2010

Evidence301
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12009299
xref: http://identifiers.org/pubmed/16359702
xref: http://identifiers.org/pubmed/218932
comment: Cytosolic GMP reductase (GMPR) catalyzes the reaction of GMP and NADPH + H+ to yield IMP and NADP+ + NH4+ (Spector et al. 1979; Deng et al. 2002). Two GMPR proteins have been identified, GMPR and GMPR2. Both proteins form homotetramers (GMPR - unpublished crstallographic data PDB 2BLE; GMPR2 - Li et al. 2006).

Evidence302
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/4620886
comment: Nucleosides and free bases generated by DNA and RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathway of purine biosynthesis. Nucleosides and free bases generated by DNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathway of purine biosynthesis. Nucleosides and free bases generated by RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathways of purine biosynthesis. Under normal conditions, DNA turnover is limited and deoxyribonucleotide salvage operates at a correspondingly low level (Watts 1974).

Evidence307
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8619816
xref: http://identifiers.org/pubmed/4684686
comment: The synthesis of carbamoyl phosphate from glutamine, bicarbonate, and ATP is catalyzed by the carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity of cytosolic trifunctional CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) protein (Ito and Uchino 1973; Iwahana et al. 1996). The purified human protein is active in several different oligomerization states, as is its Syrian hamster homologue. The most abundant form of the latter is a hexamer, and the active human protein is annotated as a hexamer by inference (Ito and Uchino 1973; Lee et al. 1985).

UnificationXref1117
type: UnificationXref
id: REACT_17719
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17719.2

Homologues of Btn-MCCC1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2458
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4233741

Evidence308
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8619816
xref: http://identifiers.org/pubmed/4684686
xref: http://identifiers.org/pubmed/2995985
comment: The synthesis of N-carbamoyl L-aspartate from carbamoyl phosphate and L-aspartate is catalyzed by the aspartate carbamoyltansferase activity of cytosolic trifunctional CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) protein (Ito and Uchino 1973; Iwahana et al. 1996). The purified human protein is active in several different oligomerization states as is its Syrian hamster homologue. The most abundant form of the latter is a hexamer, and the active human protein is annotated as a hexamer by inference (Ito and Uchino 1973; Lee et al. 1985).

UnificationXref1116
type: UnificationXref
id: 191328
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191328

Evidence305
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/4620886
comment: The purine bases guanine and hypoxanthine (derived from adenine by events in the purine salvage pathways) are converted to xanthine and then to uric acid, which is excreted from the body (Watts 1974). The end-point of this pathway in humans and hominoid primates is unusual. Most other mammals metabolize uric acid further to yield more soluble end products, and much speculation has centered on possible roles for high uric acid levels in normal human physiology.

UnificationXref1119
type: UnificationXref
id: 4234994
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234994

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P64803
data source: Provenance1
name: P64803
name: MMAB_HUMAN
name: MMAB
xref: UnificationXref2429
feature: FragmentFeature196
cellular location: GO:0005622
comment: Reactome DB_ID: 4236040
display name: Cob

Evidence306
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/4620886
comment: The events of human purine metabolism are conveniently, if somewhat arbitrarily, grouped into four pathways: de novo synthesis of inosine 5'-monophosphate (IMP), the biosynthesis of other purine ribo- and deoxyribonucleotides, purine salvage reactions, and purine catabolism (Watts 1974). De novo synthesis of inosine 5'-monophosphate (IMP). The purine ribonucleotide IMP is assembled on 5-phospho-alpha-D-ribose 1-diphosphate (PRPP). Purine biosynthesis [interconversion]. Purine ribo- and deoxyribonucleotide di- and triphosphates are synthesized, both from IMP and from guanosine and adenosine ribo- and deoxyribonucleotide monophosphates generated in salvage reactions. Purine salvage reactions. Purine nucleosides and free bases generated by DNA and RNA breakdown are converted to nucleotide monophosphates. Purine catabolism. The purine bases guanine and hypoxanthine are degraded to uric acid, which is excreted from the body.

UnificationXref1118
type: UnificationXref
id: 4234993
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P95127
data source: Provenance1
name: Pyruvic carboxylase
name: Pyruvate carboxylase, mitochondrial precursor
name: pyruvate carboxylase
name: P95127
xref: UnificationXref2450
feature: FragmentFeature197
feature: ModificationFeature36
cellular location: GO:0005622
comment: Reactome DB_ID: 4236027
display name: Btn-PC

CHEBI:63546
type: SmallMoleculeReference
name: CHEBI:63546 [ChEBI:63546]
xref: UnificationXref1583

UnificationXref1113
type: UnificationXref
id: REACT_17089
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17089.2

PublicationXref203
type: PublicationXref
id: 0079130356
author: Ding, J
author: Roe, CR
db: ISBN
title: Mitochondrial fatty acid oxidation disorders
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 2297-2326
year: 2001

UnificationXref1112
type: UnificationXref
id: 389589
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389589

Evidence309
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8619816
comment: The synthesis of dihydroorotate from N-carbamoyl L-aspartate is catalyzed by the dihydroorotase activity of cytosolic trifunctional CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) protein. This activity has not been directly demonstrated in experimental studies of the purified human protein, but has been inferred from the behavior of the purified hamster protein and the high degree of sequence similarity between the cloned hamster and human genes (Iwahana et al. 1996). Also on the basis of this similarity, the active human protein is annotated as a hexamer (Lee et al. 1985).

UnificationXref1115
type: UnificationXref
id: 4234992
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234992

UnificationXref1114
type: UnificationXref
id: O53639
db: UniProt

CHEBI:63540
type: SmallMoleculeReference
name: CHEBI:63540 [ChEBI:63540]
xref: UnificationXref1556

UnificationXref1111
type: UnificationXref
id: CHEBI:18290
db: ChEBI

http://identifiers.org/pubmed/3944130
type: PublicationXref
id: 3944130
author: Forte-McRobbie, CM
author: Pietruszko, R
db: Pubmed
title: Purification and characterization of human liver "high Km" aldehyde dehydrogenase and its identification as glutamic gamma-semialdehyde dehydrogenase.
source: J Biol Chem 261:2154-63
year: 1986

UnificationXref1110
type: UnificationXref
id: REACT_17891
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17891.1

O53770
type: Protein
entity reference: O53770
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Nicotinate phosphoribosyltransferase
xref: UnificationXref2496
feature: FragmentFeature204
cellular location: GO:0005622
comment: Reactome DB_ID: 4234668
display name: NAPRT1

Homologues of NAPRT1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: O53770
xref: UnificationXref2499
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234672

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A5S6
data source: Provenance1
name: Putative inorganic polyphosphate/ATP-NAD kinase
name: PPNK_HUMAN
name: P0A5S6
xref: UnificationXref2488
feature: FragmentFeature203
cellular location: GO:0005622
comment: Reactome DB_ID: 4234679
display name: NADK

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A5L6
data source: Provenance1
name: NADSYN1
name: NADE1_HUMAN
name: Glutamine-dependent NAD(+) synthetase
xref: UnificationXref2483
feature: FragmentFeature202
cellular location: GO:0005622
comment: Reactome DB_ID: 4234690
display name: P0A5L6

Evidence300
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6300847
comment: Cytosolic hypoxanthine-guanine phosphoribosyltransferase (HPRT1) tetramer catalyzes the reactions of guanine or hypoxanthine with PRPP to form GMP ir IMP and pyrophosphate (Holden and Kelley 1978; Jolly et al. 1983).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O06594
data source: Provenance1
name: Nicotinate-nucleotide pyrophosphorylase (carboxylating)
name: O06594
xref: UnificationXref2476
feature: FragmentFeature201
cellular location: GO:0005622
comment: Reactome DB_ID: 4234685
display name: QPRT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O06165
data source: Provenance1
name: methylcrotonyl-CoA carboxylase beta chain
name: O06165
xref: UnificationXref2460
feature: FragmentFeature200
cellular location: GO:0005622
comment: Reactome DB_ID: 4233732
display name: MCCC2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A508
data source: Provenance1
name: Btn-MCCC1
name: methylcrotonyl-CoA carboxylase alpha chain
xref: UnificationXref2457
feature: ModificationFeature38
feature: FragmentFeature199
cellular location: GO:0005622
comment: Reactome DB_ID: 4233740
display name: P0A508

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P71538
data source: Provenance1
name: Btn-MCCC1
name: methylcrotonyl-CoA carboxylase alpha chain
xref: UnificationXref2455
feature: ModificationFeature37
feature: FragmentFeature198
cellular location: GO:0005622
comment: Reactome DB_ID: 4233736
display name: P71538

Homologues of 2xHC-TXN
type: Protein
data source: Provenance1
member physical entity: SASP
xref: UnificationXref2273
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234367

SASP
type: Protein
entity reference: Q7D8E1
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: Q7D8E1
name: ATL-derived factor
name: thioredoxin, oxidized
name: 2xHC-TXN
name: Surface associated sulphydryl protein
xref: UnificationXref2271
feature: ModificationFeature32
feature: ModificationFeature33
feature: FragmentFeature187
cellular location: GO:0005622
comment: Reactome DB_ID: 4234363
display name: ADF

SASP
type: Protein
entity reference: UniProt:O53161
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: O53161
name: ATL-derived factor
name: thioredoxin, oxidized
name: 2xHC-TXN
name: Surface associated sulphydryl protein
xref: UnificationXref2272
feature: ModificationFeature34
feature: ModificationFeature35
feature: FragmentFeature188
cellular location: GO:0005622
comment: Reactome DB_ID: 4234366
display name: ADF

Homologues of RRM2B
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2278
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234370

UnificationXref2298
type: UnificationXref
id: CHEBI:16497
db: ChEBI

UnificationXref2299
type: UnificationXref
id: 110672
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110672

UnificationXref2296
type: UnificationXref
id: 29494
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29494

UnificationXref2297
type: UnificationXref
id: REACT_3409
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3409.1

UnificationXref2295
type: UnificationXref
id: CHEBI:15713
db: ChEBI

UnificationXref2294
type: UnificationXref
id: REACT_5335
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5335.1

UnificationXref2293
type: UnificationXref
id: 110614
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110614

UnificationXref2292
type: UnificationXref
id: CHEBI:17677
db: ChEBI

UnificationXref2291
type: UnificationXref
id: REACT_21492
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21492.1

UnificationXref2290
type: UnificationXref
id: 482627
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=482627

MT2963
type: ProteinReference
name: UniProt:P65049 Rv2895c
name: Rv2895c
name: MTCY274.26c
xref: UnificationXref4907
comment: SIMILARITY Contains 1 FAD-binding FR-type domain.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q10840
data source: Provenance1
name: Q10840
name: ribonucleotide reductase M2B (TP53 inducible)
xref: UnificationXref2276
feature: FragmentFeature189
cellular location: GO:0005622
comment: Reactome DB_ID: 4234368
display name: RRM2B

http://identifiers.org/pubmed/11435397
type: PublicationXref
id: 11435397
author: Allikmets, R
author: Dean, M
author: Rzhetsky, A
db: Pubmed
title: The human ATP-binding cassette (ABC) transporter superfamily
source: Genome Res 11:1156-66
year: 2001

non-metastatic cells 1, protein (NM23A) expressed in
type: Protein
entity reference: P84284
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Tumor metastatic process-associated protein
name: Nucleoside diphosphate kinase A
name: nm23-H1
name: Metastasis inhibition factor nm23
name: NDP kinase A
name: P84284
name: NME1(2-152)
xref: UnificationXref2312
feature: FragmentFeature191
cellular location: GO:0005622
comment: Reactome DB_ID: 4235167
display name: NDK A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q50549
data source: Provenance1
name: Q50549
name: ribonucleotide reductase M2B (TP53 inducible)
xref: UnificationXref2277
feature: FragmentFeature190
cellular location: GO:0005622
comment: Reactome DB_ID: 4234369
display name: RRM2B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P64307
data source: Provenance1
name: P64307
name: Inosine triphosphate pyrophosphatase
xref: UnificationXref2362
feature: FragmentFeature193
cellular location: GO:0005622
comment: Reactome DB_ID: 4236001
display name: ITPA

Nucleoside diphosphate kinase, mitochondrial
type: Protein
entity reference: P84284
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: nm23-H4
name: non-metastatic cells 4, protein expressed in
name: NDP kinase, mitochondrial
name: P84284
xref: UnificationXref2350
feature: FragmentFeature192
cellular location: GO:0005622
comment: Reactome DB_ID: 4235172
display name: NME4

PNPO(1-216)
type: Protein
entity reference: UniProt:P65682
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P65682
name: Pyridoxine-5'-phosphate oxidase
xref: UnificationXref2411
feature: FragmentFeature195
cellular location: GO:0005622
comment: Reactome DB_ID: 4235379
display name: PNPO

http://identifiers.org/pubmed/16098809
type: PublicationXref
id: 16098809
author: Simmonds, HA
author: Zameitat, E
author: Fairbanks, LD
author: Marinaki, AM
author: Loffler, M
db: Pubmed
title: Pyrimidine pathways in health and disease
source: Trends Mol Med 11:430-7
year: 2005

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P67733
data source: Provenance1
name: Phosphopantothenoylcysteine decarboxylase
name: COAC_HUMAN
name: P67733
xref: UnificationXref2393
feature: FragmentFeature194
cellular location: GO:0005622
comment: Reactome DB_ID: 4234662
display name: PPCDC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53367
data source: Provenance1
name: O53367
name: Cytidine deaminase
name: Cytidine aminohydrolase
xref: UnificationXref2191
feature: FragmentFeature180
cellular location: GO:0005622
comment: Reactome DB_ID: 4233916
display name: CDA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P69440
data source: Provenance1
name: Adenylate kinase isoenzyme 2, mitochondrial
name: adenylate kinase 2
name: P69440
name: ATP-AMP transphosphorylase
name: Adenylate kinase isoenzyme 2, mitochondrial (EC 2.7.4.3) (ATP-AMP transphosphorylase)
xref: UnificationXref2204
feature: FragmentFeature181
cellular location: GO:0005622
comment: Reactome DB_ID: 4234255
display name: AK2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A552
data source: Provenance1
name: deoxyuridine triphosphatase isoform 2
name: P0A552
name: dUTP pyrophosphatase
xref: UnificationXref2139
feature: FragmentFeature178
cellular location: GO:0005622
comment: Reactome DB_ID: 4233935
display name: DUT-2

Thymidine phosphorylase precursor
type: Protein
entity reference: O53366
data source: Provenance1
name: Thymidine phosphorylase precursor (EC 2.4.2.4) (TdRPase) (TP) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (Gliostatin)
name: Note: the coordinates are copied over from Homo sapiens.
name: endothelial cell growth factor 1 (platelet-derived)
name: TYMP
name: PD-ECGF
name: TdRPase
name: thymidine phosphorylase
name: Gliostatin
name: O53366
name: Platelet-derived endothelial cell growth factor
xref: UnificationXref2173
feature: FragmentFeature179
cellular location: GO:0005622
comment: Reactome DB_ID: 4234430
display name: TP

Conversion of palmitic acid to very long chain fatty acyl-CoAs
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction53
evidence: Evidence109
xref: UnificationXref720
xref: UnificationXref719
xref: RelationshipXref99
pathway order: PathwayStep106
display name: Synthesis of very long-chain fatty acyl-CoAs
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/18799456
type: PublicationXref
id: 18799456
author: Singh, M
author: Oehlmann, W
author: Schnell, R
author: Agren, D
author: Schneider, G
db: Pubmed
title: Cysteine synthase (CysM) of Mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: evidence for an alternative cysteine biosynthesis pathway in mycobacteria
source: J Biol Chem 283:31567-74
year: 2008

Homologues of TXN
type: Protein
data source: Provenance1
member physical entity: SASP
xref: UnificationXref2213
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4233932

http://identifiers.org/pubmed/183599
type: PublicationXref
id: 183599
author: Hers, HG
db: Pubmed
title: The control of glycogen metabolism in the liver
source: Annu Rev Biochem 45:167-89
year: 1976

SASP
type: Protein
entity reference: UniProt:O53161
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: O53161
name: ATL-derived factor
name: ADF
name: Surface associated sulphydryl protein
xref: UnificationXref2212
feature: FragmentFeature183
cellular location: GO:0005622
comment: Reactome DB_ID: 4233931
display name: TXN

SASP
type: Protein
entity reference: Q7D8E1
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: Q7D8E1
name: ATL-derived factor
name: ADF
name: Surface associated sulphydryl protein
xref: UnificationXref2210
feature: FragmentFeature182
cellular location: GO:0005622
comment: Reactome DB_ID: 4233930
display name: TXN

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A5W8
data source: Provenance1
name: P0A5W8
name: Ribonucleoside-diphosphate reductase M1 chain (EC 1.17.4.1) (Ribonucleotide reductase large chain)
name: Ribonucleoside-diphosphate reductase M1 chain
name: ribonucleotide reductase M1 polypeptide
name: Ribonucleotide reductase large chain
xref: UnificationXref2240
feature: FragmentFeature186
cellular location: GO:0005622
comment: Reactome DB_ID: 4234346
display name: RRM1

SASP
type: Protein
entity reference: UniProt:O53161
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: Thioredoxin, oxidized
name: O53161
name: ATL-derived factor
name: 2xHC-TXN
name: Surface associated sulphydryl protein
xref: UnificationXref2237
feature: ModificationFeature31
feature: ModificationFeature30
feature: FragmentFeature185
cellular location: GO:0005622
comment: Reactome DB_ID: 4233928
display name: ADF

SASP
type: Protein
entity reference: Q7D8E1
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: Thioredoxin, oxidized
name: Q7D8E1
name: ATL-derived factor
name: 2xHC-TXN
name: Surface associated sulphydryl protein
xref: UnificationXref2236
feature: FragmentFeature184
feature: ModificationFeature29
feature: ModificationFeature28
cellular location: GO:0005622
comment: Reactome DB_ID: 4233923
display name: ADF

Homologues of 2xHC-TXN
type: Protein
data source: Provenance1
member physical entity: SASP
xref: UnificationXref2238
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4233929

UnificationXref759
type: UnificationXref
id: 4236110
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236110

Evidence350
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9473669
comment: The enzyme, nicotinate nucleotide pyrophosphorylase, is specific for quinolinate. Its activity is strictly dependent on Mg2+ ions being present. A phosphoribosyl group is transferred to quinolinate to form nicotinate D-ribonucleotide. This reaction represents another rate-limiting step of the pathway from tryptophan to NAD+.

Evidence351
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12547821
comment: NAD synthase catalyzes the final step in the biosynthesis of NAD+, both in the de novo synthesis and in the salvage pathways. The enzyme makes use of glutamine as an amide donor in the reaction. NAD synthase exists as a homohexamer in the cytosol. There are two forms of NAD synthase in humans, NADsyn1 and NADsyn2. The major difference between the two forms is that NADsyn1 appears to be glutamine-dependent whereas NADsyn2 is strictly ammonia-dependent.

UnificationXref4299
type: UnificationXref
id: REACT_88946
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88946.9

UnificationXref4298
type: UnificationXref
id: 4236094
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236094

Evidence354
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/14704851
comment: Nicotinamide levels are modulated by the action of three enzymes involved in nicotinamide salvaging. They are nicotinamide deaminase, nicotinamide phosphoribosyltransferase and nicotinate phosphoribosyltransferase. These enzymes are poorly characterized in humans, depsite their importance in nicotinamide utilization.

Evidence355
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/14704851
comment: Nicotinate (niacin) and nicotinamide are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). When NAD+ and NADP+ are interchanged in a reaction with their reduced forms, NADH and NADPH respectively, they are important cofactors in several hundred redox reactions. Nicotinate is synthesized from 2-amino-3-carboxymuconate semialdehyde, an intermediate in the catabolism of the essential amino acid tryptophan.

Evidence352
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11594753
comment: NAD+ kinase catalyzes the transfer of a phosphate group from ATP to NAD+, forming NADP+. This is the only way to generate NADP+ in all living organisms. The enzyme requires a divalent metal to be effective. Zn2+ is the best metal for this purpose.

Evidence353
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17604275
xref: http://identifiers.org/pubmed/13563527
xref: http://identifiers.org/pubmed/4349867
comment: Cytosolic nicotinate phosphoribosyltransferase (NaPRT) catalyzes the Mg++-dependent reaction of nicotinate and phosphoribosyl pyrophosphate to form nicotinate mononucleotide (NaMN, nicotinate D-ribonucleotide) and pyrophosphate. The active form of the enzyme is a homodimer (Preiss and Handler 1958; Niedel and Dietrich 1973; Hara et al. 2007).

UnificationXref751
type: UnificationXref
id: 426755
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426755

http://identifiers.org/pubmed/11519011
type: PublicationXref
id: 11519011
author: FitzPatrick, DR
author: Hennekam, RC
author: Kelley, RI
author: Andersson, HC
author: Waterham, HR
author: Romeijn, GJ
author: Koster, J
author: Vreken, P
db: Pubmed
title: Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis
source: Am J Hum Genet 69:685-94
year: 2001

UnificationXref752
type: UnificationXref
id: REACT_120138
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120138.1

UDP-D-galactose [ChEBI:18307]
type: SmallMoleculeReference
name: UDP-D-galactopyranose
name: UDPgalactose
name: UDP-D-galactose
xref: UnificationXref112

UnificationXref1140
type: UnificationXref
id: 4235021
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235021

UnificationXref753
type: UnificationXref
id: O53208
db: UniProt

UnificationXref754
type: UnificationXref
id: 4234154
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234154

http://identifiers.org/pubmed/3955067
type: PublicationXref
id: 3955067
author: Fredrikson, G
author: Tornqvist, H
author: Belfrage, P
db: Pubmed
title: Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol
source: Biochim Biophys Acta 876:288-93
year: 1986

UnificationXref755
type: UnificationXref
id: 4234155
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234155

UnificationXref756
type: UnificationXref
id: 4234156
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234156

UnificationXref757
type: UnificationXref
id: 4234158
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234158

UnificationXref758
type: UnificationXref
id: REACT_154164
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154164.3

UnificationXref1145
type: UnificationXref
id: CHEBI:15539
db: ChEBI

UnificationXref1146
type: UnificationXref
id: 192314
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192314

UnificationXref1147
type: UnificationXref
id: REACT_10735
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10735.1

DAP12 signaling
type: Pathway
data source: Provenance1
pathway component: REACT 114367.8
evidence: Evidence699
xref: UnificationXref4627
xref: UnificationXref4628
pathway order: PathwayStep488
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1148
type: UnificationXref
id: CHEBI:15495
db: ChEBI

UnificationXref1141
type: UnificationXref
id: REACT_89909
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89909.9

UnificationXref1142
type: UnificationXref
id: CHEBI:15371
db: ChEBI

Deamido-NAD+
type: SmallMoleculeReference
name: Deamino-NAD+
name: Deamino-NAD+ [ChEBI:4340]
xref: UnificationXref2479

UnificationXref1143
type: UnificationXref
id: 389996
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389996

UnificationXref761
type: UnificationXref
id: CHEBI:16238
db: ChEBI

UnificationXref1144
type: UnificationXref
id: REACT_18106
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18106.1

UnificationXref760
type: UnificationXref
id: REACT_30474
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30474.10

UnificationXref4292
type: UnificationXref
id: 4234426
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234426

Evidence359
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3871768
xref: http://identifiers.org/pubmed/3053686
comment: The formate-tetrahydrofolate ligase activity of the trifunctional MTHFD1 enzyme catalyzes the reaction of THF polyglutamate, formate, and ATP to form 10-formylTHF polyglutamate, ADP, and orthophosphate. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

UnificationXref4293
type: UnificationXref
id: 4234427
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234427

Evidence358
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8662720
xref: http://identifiers.org/pubmed/1409616
comment: Mitochondrial folylpolyglutamate synthase catalyzes the reaction of THF-glutamate(n), L-glutamate, and ATP to form THF-glutamate(n+1), ADP, and orthophosphate. (The first glutamate residue is attached to the glutamate moiety of THF itself; for convenience the process is annotated here as if it proceeded in a single concerted step.) The extent of conjugation is variable, but the commonest mitochondrial form of THF has six added glutamate residues. Although its properties as a donor of one-carbon units are not affected by glutamate addition, THF that lacks added glutamate residues cannot be retained in the mitochondrial matrix so this reaction is needed for normal THF function under physiological conditions. The mitochondrial and cytosolic forms of folylpolyglutamate synthase are encoded by the same gene - alternative splicing generates mRNA with or without an initial exon encoding a mitochondrial targeting sequence (Garrow et al. 1992; Chen et al. 1996).

Synthesis of bile acids and bile salts via 27-hydroxycholesterol
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction126
pathway component: BiochemicalReaction125
evidence: Evidence215
xref: UnificationXref1447
xref: UnificationXref1446
xref: RelationshipXref183
pathway order: PathwayStep212
pathway order: PathwayStep211
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref4290
type: UnificationXref
id: 4234424
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234424

Evidence357
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8662720
xref: http://identifiers.org/pubmed/1409616
comment: Cytosolic folylpolyglutamate synthase catalyzes the reaction of 5-methylTHF-glutamate(n), L-glutamate, and ATP to form 5-methylTHF-glutamate(n+1), ADP, and orthophosphate. (The first glutamate residue is attached to the glutamate moiety of 5-methylTHF itself; for convenience the process is annotated here as if it proceeded in a single concerted step.) The extent of conjugation is variable, but the commonest cytosolic form of 5-methylTHF has five added glutamate residues. Although its properties as a donor of one-carbon units are not affected by glutamate addition, 5-methylTHF that lacks added glutamate residues cannot be retained in the cytosol so this reaction is needed for normal 5-methylTHF function under physiological conditions (Garrow et al. 1992; Chen et al. 1996).

UnificationXref4291
type: UnificationXref
id: 4234425
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234425

Evidence356
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8662720
xref: http://identifiers.org/pubmed/1409616
comment: Cytosolic folylpolyglutamate synthase catalyzes the reaction of THF-glutamate(n), L-glutamate, and ATP to form THF-glutamate(n+1), ADP, and orthophosphate. (The first glutamate residue is attached to the glutamate moiety of THF itself; for convenience the process is annotated here as if it proceeded in a single concerted step.) The extent of conjugation is variable, but the commonest cytosolic form of THF has five added glutamate residues. Although its properties as a donor of one-carbon units are not affected by glutamate addition, THF that lacks added glutamate residues cannot be retained in the cytosol so this reaction is needed for normal THF function under physiological conditions (Garrow et al. 1992; Chen et al. 1996).

UnificationXref4296
type: UnificationXref
id: 4236175
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236175

UnificationXref1149
type: UnificationXref
id: 390002
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390002

UnificationXref4297
type: UnificationXref
id: REACT_30664
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30664.10

UnificationXref4294
type: UnificationXref
id: 4236176
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236176

UnificationXref4295
type: UnificationXref
id: REACT_77089
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77089.9

Evidence340
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15182361
comment: Pyridoxine-5'-phosphate oxidase (PNPO) is able to oxidize pyridoxamine phosphate (PXAP) to pyridoxal 5'-phosphate (PXLP) (Kang et al. 2004).

Evidence341
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15182361
comment: Pyridoxine-5'-phosphate oxidase (PNPO) is able to oxidize pyridoxine phosphate (PDXP) to pyridoxal 5'-phosphate (PXLP) (Kang et al. 2004).

Evidence342
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10024608
comment: Animals cannot synthesize pyridoxal 5'-phosphate (PLP) which is a ligand in aminotransferases and other enzymes. PLP's accessible derivatives pyridoxine, pyridoxal, and pyridoxamine are traditionally called vitamins B6. They are taken up nutritionally from bacteria and plants, but also created from PLP in the body. The pathways used to recycle PLP from these three compounds can therefore be called vitamin B6 activation as well as PLP salvage. Because of the close similarity of the molecules, only two enzymes are needed for the task (McCormick & Chen, 1999).

Evidence343
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18251506
xref: http://identifiers.org/pubmed/12514191
xref: http://identifiers.org/pubmed/12438653
comment: Mitochondrial cob(I)yrinic acid a,c-diamide adenosyltransferase (MMAB) is a dual purpose enzyme involved in the reduction and adenosylation of cobalamin. In the first step, MMAB reduces cob(II)alamin (B12r) to cob(I)alamin (B12s) (Fan & Bobik 2008, Leal et al. 2003). Defects in MMAB cause methylmalonic aciduria type cblB (MMAB aka methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type; MIM:251110). Affected individuals have methylmalonic aciduria and metabolic ketoacidosis, despite a functional methylmalonyl-CoA mutase. In severe cases, newborns are lethargic, prone to vomiting and fail to thrive (Dobson et al. 2002).

Evidence344
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18251506
xref: http://identifiers.org/pubmed/12514191
xref: http://identifiers.org/pubmed/12438653
comment: Mitochondrial cob(I)yrinic acid a,c-diamide adenosyltransferase (MMAB) is a dual purpose enzyme involved in the reduction and adenosylation of cobalamin. In the second step, MMAB transfers an adenosyl group from ATP to cob(I)alamin (B12s) to form adenosylcabalamin (AdoCbl) (Fan & Bobik 2008, Leal et al. 2003). Defects in MMAB cause methylmalonic aciduria type cblB (MMAB aka methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type; MIM:251110). Affected individuals have methylmalonic aciduria and metabolic ketoacidosis, despite a functional methylmalonyl-CoA mutase. In severe cases, newborns are lethargic, prone to vomiting and fail to thrive (Dobson et al. 2002).

UnificationXref1151
type: UnificationXref
id: O33332
db: UniProt

UnificationXref764
type: UnificationXref
id: CHEBI:15525
db: ChEBI

1-(5'-Phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole
type: SmallMoleculeReference
name: 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide
name: SAICAR
name: 5'-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole
name: 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole [ChEBI:18319]
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
name: 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
xref: UnificationXref1905

UnificationXref1150
type: UnificationXref
id: REACT_18090
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18090.1

UnificationXref765
type: UnificationXref
id: 77281
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77281

UnificationXref762
type: UnificationXref
id: 113596
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113596

UnificationXref763
type: UnificationXref
id: REACT_5229
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5229.1

http://identifiers.org/pubmed/8576151
type: PublicationXref
id: 8576151
author: Smith, B
author: Knight, G
author: Knäuper, V
author: Murphy, G
author: López-Otin, C
db: Pubmed
title: Biochemical characterization of human collagenase-3
source: J Biol Chem 271:1544-50
year: 1996

UnificationXref768
type: UnificationXref
id: 31649
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31649

UnificationXref769
type: UnificationXref
id: REACT_3082
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3082.1

UnificationXref766
type: UnificationXref
id: REACT_5080
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5080.2

UnificationXref767
type: UnificationXref
id: CHEBI:17877
db: ChEBI

UnificationXref1158
type: UnificationXref
id: REACT_17437
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17437.2

UnificationXref1159
type: UnificationXref
id: CHEBI:15366
db: ChEBI

UnificationXref1156
type: UnificationXref
id: REACT_3341
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3341.1

UnificationXref1157
type: UnificationXref
id: 353123
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=353123

UnificationXref1154
type: UnificationXref
id: REACT_95403
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95403.9

UnificationXref772
type: UnificationXref
id: REACT_4177
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4177.1

UnificationXref1155
type: UnificationXref
id: 141343
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=141343

UnificationXref771
type: UnificationXref
id: 77284
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77284

UnificationXref1152
type: UnificationXref
id: 4234590
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234590

UnificationXref770
type: UnificationXref
id: CHEBI:28935
db: ChEBI

UnificationXref1153
type: UnificationXref
id: 4235022
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235022

Evidence346
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/21511966
comment: Multidrug resistance-associated protein 1 (ABCC1, MRP1) can specifically mediate the ATP-dependant export of free cobalamin (Cbl aka vitamin B12) from small intestine cells to the portal vein (Shah et al. 2011).

Evidence345
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16281286
xref: http://identifiers.org/pubmed/2567699
xref: http://identifiers.org/pubmed/12438653
xref: http://identifiers.org/pubmed/15523652
comment: Methylmalonyl-CoA mutase (MUT aka MCM) (Jansen et al. 1989) utilises adenosylcobalamin (AdoCbl) as a cofactor and transfers an adenosyl group from AdoCbl to methymalonyl-CoA to form succinyl-CoA, a precursor for the citric acid cycle. MUT has a homodimeric structure and is located in the mitochondrial matrix. Defects in MUT cause methylmalonic aciduria type mut (MMAM; MIM:251000), an often fatal disorder of organic acid metabolism (Worgan et al. 2006). Methylmalonic aciduria type A protein (MMAA) (Dobson et al. 2002) is thought to act as a chaperone to MUT and is suggested to play a dual role with regards to MUT protection and reactivation. Defects in MMAA cause methylmalonic aciduria type cblA (MMAA aka methylmalonic aciduria type A or vitamin B12-responsive methylmalonicaciduria of cblA complementation type; MIM:251100). Affected individuals accumulate methylmalonic acid in the blood and urine and are prone to potentially life threatening acidotic crises in infancy or early childhood (Dobson et al. 2002, Lerner-Ellis et al. 2004).

Evidence348
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/22123817
xref: http://identifiers.org/pubmed/9630604
xref: http://identifiers.org/pubmed/20153287
comment: Once biotinylated, three halocarboxylases (hCBXs) are localised to the mitochondrial matrix. The mechanism of transfer is still unclear. Pyruvate carboxylase (PC) is required for gluconeogenesis, lipogenesis, neurotransmitter synthesis and insulin secretion; Methylcrotonyl-CoA carboxylase (MCC) is required for amino acid metabolism; propionyl-CoA carboxylase (PCC) is required for odd-chain fatty acid oxidation (Ingaramo & Beckett 2012, Hiratsuka et al. 1998, Bailey et al. 2010).

Evidence347
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/21312325
xref: http://identifiers.org/pubmed/20185591
xref: http://identifiers.org/pubmed/19832808
xref: http://identifiers.org/pubmed/10448521
comment: Vitamin B12 (cobalamin, Cbl) is a water-soluble vitamin with a key role in blood formation and normal functioning of the brain and nervous system. Cbl consists of a planar corrin ring coordinating with a cobalt atom through four nitrogen atoms. A 5,6-dimethylbenzamidizole base coordinates with the cobalt atom in the lower axial position while a number of different species can coordinate with the cobalt atom in the upper axial position. It is the cobalt-corrin ring complex that gives all Cbls a deep red colour. Only bacteria and archaea are able to synthesize Cbl thus humans need a dietary intake to prevent deficiency (Green 2010, Quadros 2010, Watkins & Rosenblatt 2011). A common semi-synthetic form of the vitamin, cyanocobalamin (CNCbl, where a cyanide group is in the upper axial position), is produced from bacterial hydroxocobalamin and used in many pharmaceuticals, supplements and as a food additive. In mammalian cells, Cbl or CNCbl is converted to two active coenzyme derivatives; methylcobalamin (MetCbl) and adenosylcobalamin (AdoCbl). MetCbl is required for activity of the cytoplasmic enzyme methionine synthase, which converts homocysteine to methionine. AdoCbl is required for activity of the mitochondrial enzyme methylmalonyl CoA mutase, which converts L-methylmalonyl-CoA to succinyl-CoA (Seetharam 1999). This pathway outlines the intake, transport and metabolism of Cbl and is assumed to be equally applicable to CNCbl.

Evidence349
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19319844
comment: Biotin (Btn) is an essential cofactor in a variety of carboxylation reactions (Zempleni et al. 2009). Humans cannot synthesize Btn but it is abundant in the human diet and can be taken up from the intestinal lumen by the SLC5A6 transporter. Its uptake, intracellular translocation, covalent conjugation to apoenzymes, and salvage are described here.

Evidence332
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/177353
xref: http://identifiers.org/pubmed/5940
xref: http://identifiers.org/pubmed/11008000
xref: PublicationXref490
xref: PublicationXref488
comment: An array of kinases catalyze the reversible phosphorylation of nucleotide monophosphates to form nucleotide diphosphates and triphosphates. Nucleoside monophosphate kinases catalyze the reversible phosphorylation of nucleoside and deoxynucleoside 5'-monophosphates to form the corresponding nucleoside 5'-diphosphates. Most appear to have restricted specificities for nucleoside monophosphates, and to use ATP preferentially (Van Rompay et al. 2000; Anderson 1973; Noda 1973). The total number of human enzymes that catalyze these reactions in vivo is not clear. In six cases, a well-defined biochemical activity has been associated with a purified protein, and these are annotated here. However, additional nucleoside monophosphate kinase-like human proteins have been identified in molecular cloning studies whose enzymatic activities are unknown, and several distinctive nucleoside monophosphate kinase activities detected in cell extracts, e.g., a GTP-requiring adenylate kinase activity (Wilson et al. 1976) and one or more guanylate kinase activities (Jamil et al. 1975) have not been unambiguously associated with specific human proteins. The nucleoside monophosphates against which each of the six well-characterized enzymes is active is shown in the table (Van Rompay et al. 2000). All six efficiently use ATP as a phosphate donor, but have some activity with other nucleoside triphosphates as well in vitro. The high concentrations of ATP relative to other nucleoside triphosphates in vivo makes it the likely major phosphate donor in these reactions under most conditions. All of these phosphorylation reactions are freely reversible in vitro when carried out with purified enzymes and substrates, having equilibrium constants near 1. In vivo, high ratios of ATP to ADP are likely to favor the forward direction of these reactions, i.e., the conversion of (d)NMP and ATP to (d)NDP and ADP. At the same time, the reversibility of the reactions and the overlapping substrate specificities of…

Evidence333
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11278832
xref: http://identifiers.org/pubmed/20081199
comment: Cytosolic ITPA dimer catalyzes the reaction of ITP and water to form IMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of ITP is thought to prevent its incorporation into mRNA, which would lead to aberrant protein synthesis (Lin et al. 2001; Abolhassani et al. 2010).

Evidence330
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9488696
xref: http://identifiers.org/pubmed/10799505
xref: http://identifiers.org/pubmed/18635542
comment: Nucleoside diphosphate kinase NME4 associated with the inner mitochondrial membrane (Tokarska-Schlattner et al. 2008) catalyzes the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates with ATP to form the corresponding nucleoside 5'-triphosphates and ADP. The active form of the enzyme is a hexamer of NME4 polypeptides whose amino-terminal 33 residues, a mitochondrial translocation signal, have been removed (Milon et al. 2000). The substrate specificity of NME4 has not been examined in detail but is inferred to be broad like that of the homologous NME1, 2, and 3 kinases (Schaertl et al. 1998).

Evidence331
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9488696
xref: http://identifiers.org/pubmed/10799505
xref: http://identifiers.org/pubmed/18635542
comment: Nucleoside diphosphate kinase NME4 associated with the inner mitochondrial membrane (Tokarska-Schlattner et al. 2008) catalyzes the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates with ADP to form the corresponding nucleoside 5'-diphosphates and ATP. The active form of the enzyme is a hexamer of NME4 polypeptides whose amino-terminal 33 residues, a mitochondrial translocation signal, have been removed (Milon et al. 2000). The substrate specificity of NME4 has not been examined in detail, but is inferred to be broad like that of the homologous NME1, 2, and 3 kinases (Schaertl et al. 1998).

UnificationXref4279
type: UnificationXref
id: 4234420
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234420

UnificationXref4278
type: UnificationXref
id: 4230385
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230385

UnificationXref4277
type: UnificationXref
id: REACT_29673
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29673.10

UnificationXref4276
type: UnificationXref
id: 4234419
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234419

UnificationXref777
type: UnificationXref
id: REACT_3290
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3290.1

UnificationXref3384
type: UnificationXref
id: P65528
db: UniProt

UnificationXref778
type: UnificationXref
id: CHEBI:27402
db: ChEBI

UnificationXref3383
type: UnificationXref
id: 4235959
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235959

UnificationXref779
type: UnificationXref
id: 77300
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77300

UnificationXref3382
type: UnificationXref
id: O05783
db: UniProt

UnificationXref3381
type: UnificationXref
id: REACT_89902
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89902.9

UnificationXref773
type: UnificationXref
id: 4234205
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234205

UnificationXref3380
type: UnificationXref
id: 4236086
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236086

UnificationXref774
type: UnificationXref
id: 4234207
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234207

UnificationXref775
type: UnificationXref
id: REACT_137799
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137799.5

http://identifiers.org/pubmed/14624363
type: PublicationXref
id: 14624363
author: Bruford, EA
author: Hediger, MA
author: Rolfs, A
author: Romero, MF
author: Takanaga, H
author: Peng, JB
db: Pubmed
title: The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction
source: Pflugers Arch 447:465-8
year: 2004

UnificationXref776
type: UnificationXref
id: 113521
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113521

UnificationXref781
type: UnificationXref
id: O53872
db: UniProt

UnificationXref1120
type: UnificationXref
id: 4234996
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234996

UnificationXref780
type: UnificationXref
id: REACT_2413
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2413.1

http://identifiers.org/pubmed/1703300
type: PublicationXref
id: 1703300
author: Strauss JF, 3rd
author: Kallen, CB
author: Billheimer, JT
author: Yamamoto, R
author: Rennert, H
author: Babalola, GO
db: Pubmed
title: Cloning and expression of a cDNA encoding human sterol carrier protein 2
source: Proc Natl Acad Sci U S A 88:463-7
year: 1991

UnificationXref1121
type: UnificationXref
id: REACT_88741
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88741.9

UnificationXref783
type: UnificationXref
id: O86361
db: UniProt

UnificationXref3389
type: UnificationXref
id: 4235966
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235966

UnificationXref1122
type: UnificationXref
id: CHEBI:51340
db: ChEBI

UnificationXref782
type: UnificationXref
id: 4234190
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234190

UnificationXref1123
type: UnificationXref
id: 389612
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389612

UnificationXref3387
type: UnificationXref
id: 4235965
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235965

UnificationXref1124
type: UnificationXref
id: REACT_17113
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17113.1

UnificationXref3388
type: UnificationXref
id: 4235964
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235964

UnificationXref1125
type: UnificationXref
id: CHEBI:51341
db: ChEBI

UnificationXref3385
type: UnificationXref
id: 4235962
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235962

UnificationXref1126
type: UnificationXref
id: 389569
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389569

UnificationXref3386
type: UnificationXref
id: 4235963
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235963

UnificationXref4274
type: UnificationXref
id: 4234416
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234416

UnificationXref1127
type: UnificationXref
id: REACT_17235
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17235.1

UnificationXref4275
type: UnificationXref
id: 4234418
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234418

UnificationXref1128
type: UnificationXref
id: 4235000
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235000

UnificationXref4272
type: UnificationXref
id: 4230384
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230384

UnificationXref1129
type: UnificationXref
id: REACT_33059
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33059.10

Evidence339
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2981478
xref: http://identifiers.org/pubmed/12815048
comment: Panthothenate (vitamin B5) is the precursor of coenzyme A (Robishaw and Neely 1985) and is the prosthetic group of acyl carrier protein (ACP) (Joshi et al. 2003). Its name is derived from the Greek pantothen meaning "from everywhere" and small quantities of pantothenic acid are found in nearly every foodstuff.

UnificationXref4273
type: UnificationXref
id: Q8VK98
db: UniProt

Evidence338
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11158296
xref: http://identifiers.org/pubmed/11923312
xref: http://identifiers.org/pubmed/13032008
xref: http://identifiers.org/pubmed/2981478
xref: http://identifiers.org/pubmed/15893380
comment: Coenzyme A (CoA) is a ubiquitous cofactor that functions as an acyl group carrier in diverse processes including fatty acid metabolism and the TCA cycle (Lipmann 1953). It is synthesized from the vitamin pantothenate in a sequence of five reactions (Daugherty et al. 2002; Leonardi et al. 2005; Robishaw and Neely 1985). These reactions all occur in the cytosol or the mitochondrial intermembrane space (Leonardi et al. 2005). A recently described transport protein appears to mediate the uptake of Coenzyme A into the mitochondrial matrix (Prohl et al. 2001).

UnificationXref4270
type: UnificationXref
id: 159939
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159939

Evidence337
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11923312
xref: http://identifiers.org/pubmed/15581364
comment: The decarboxylation of phosphopantothenoylcysteine (PPC) to 4'-phosphopantetheine (PPANT) is carried out by phosphopantothenoylcysteine decarboxylase (PPCDC). PPCDC is cytosolic and exists as a homotrimer, binding one FMN cofactor per subunit. While a second isoform has been inferred from large-scale sequnceing studies, it lacks the protein's FMN-binding domain and would thus appear to be nonfunctional if it is expressed.

UnificationXref4271
type: UnificationXref
id: REACT_4598
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4598.2

Evidence336
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8283301
xref: http://identifiers.org/pubmed/20494131
xref: http://identifiers.org/pubmed/17266529
comment: Nucleotides and their derivatives are used for short-term energy storage (ATP, GTP), for intra- and extra-cellular signaling (cAMP; adenosine), as enzyme cofactors (NAD, FAD), and for the synthesis of DNA and RNA. Most dietary nucleotides are consumed by gut flora; the human body's own supply of these molecules is synthesized de novo. Additional metabolic pathways allow the interconversion of nucleotides, the salvage and reutilization of nucleotides released by degradation of DNA and RNA, and the catabolism of excess nucleotides (Rudolph 1994). These pathways are regulated to control the total size of the intracellular nucleotide pool, to balance the relative amounts of individual nucleotides, and to couple the synthesis of deoxyribonucleotides to the onset of DNA replication (S phase of the cell cycle). These pathways are also of major clinical interest as they are the means by which nucleotide analogues used as anti-viral and anti-tumor drugs are taken up by cells, activated, and catabolized (Weilin and Nordlund 2010). As well, differences in nuclotide metabolic pathways between humans and aplicomplexan parasites like Plasmodium have been exploited to design drugs to attack the latter (Hyde 2007). The movement of nucleotides and purine and pyrimidine bases across lipid bilayer membranes, mediated by SLC transporters, is annotated as part of the module "transmembrane transport of small molecules".

Evidence335
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11278832
xref: http://identifiers.org/pubmed/20081199
comment: Cytosolic ITPA dimer catalyzes the reaction of XTP and water to form XMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of XTP is thought to prevent its incorporation into mRNA, which would lead to aberrant protein synthesis (Lin et al. 2001; Abolhassani et al. 2010).

Evidence334
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11278832
xref: http://identifiers.org/pubmed/20081199
comment: Cytosolic ITPA dimer catalyzes the reaction of dITP and water to form dIMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of dITP is thought to prevent its incorporation into DNA, which would be mutagenic (Lin et al. 2001; Abolhassani et al. 2010).

Evidence320
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10989446
xref: PublicationXref461
xref: http://identifiers.org/pubmed/3090932
comment: In parallel sequences of three reactions each, thymine is converted to beta-aminoisobutyrate and uracil is converted to beta-alanine. Both of these molecules are excreted in human urine and appear to be normal end products of pyrimidine catabolism (Griffith 1986; Webster et al. 2001). Mitochondrial AGXT2, however, can also catalyze the transamination of both molecules with pyruvate, yielding 2-oxoacids that can be metabolized further by reactions of branched-chain amino acid and short-chain fatty acid catabolism (Tamaki et al. 2000). The importance of these reactions in normal human pyrimidine catabolism has not been well worked out.

Evidence321
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16098809
comment: The events of human pyrimidine metabolism are conveniently, if somewhat arbitrarily, grouped into four pathways: de novo synthesis of the pyrimidine ring and its conversion to uridine 5'-monophosphate (UMP), the biosynthesis of other pyrimidine ribo- and deoxyribonucleotides, pyrimidine salvage reactions, and pyrimidine catabolism (Loffler et al. 2005). De novo synthesis of the pyrimidine ring and its conversion to UMP. The pyrimidine base orotate is synthesized from glutamine, bicarbonate, and aspartate. Orotate reacts with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) and is then decarboxylated to form the pyrimidine nucleotide UMP. Pyrimidine biosynthesis [interconversion]. Pyrimidine ribo- and deoxyribonucleotide di- and triphosphates are synthesized, both from UMP and from pyrimidine ribonucleotide monophosphates generated in salvage reactions. Pyrimidine salvage reactions. Pyrimidine nucleosides and free bases generated by DNA and RNA breakdown are converted to nucleotide monophosphates. Pyrimidine catabolism. The pyrimidine bases thymine and uracil are degraded to beta-aminoisobutyrate and beta-alanine, respectively, which are excreted from the body.

Evidence322
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6182143
xref: http://identifiers.org/pubmed/5484814
comment: Mitochondrial adenylate kinase 2 (AK2) catalyzes the reaction of AMP and ATP to form two molecules of ADP (Hamade et al. 1982). Localization of AK2 specifically to the mitochondrial intermembrane space is inferred from studies of the homologous rat enzyme (Criss 1970).

UnificationXref4288
type: UnificationXref
id: REACT_80455
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80455.9

UnificationXref4287
type: UnificationXref
id: 4236174
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236174

UnificationXref4289
type: UnificationXref
id: 4234422
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234422

UnificationXref3393
type: UnificationXref
id: 4236368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236368

UnificationXref3392
type: UnificationXref
id: REACT_159305
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159305.3

UnificationXref788
type: UnificationXref
id: 113526
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113526

UnificationXref3395
type: UnificationXref
id: CHEBI:421707
db: ChEBI

UnificationXref789
type: UnificationXref
id: REACT_4970
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4970.1

UnificationXref3394
type: UnificationXref
id: REACT_153476
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153476.3

UnificationXref786
type: UnificationXref
id: 4234208
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234208

UnificationXref787
type: UnificationXref
id: REACT_91036
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91036.9

UnificationXref784
type: UnificationXref
id: 4234193
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234193

UnificationXref3391
type: UnificationXref
id: 4236367
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236367

UnificationXref785
type: UnificationXref
id: 4234194
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234194

UnificationXref3390
type: UnificationXref
id: REACT_158510
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158510.3

UnificationXref1132
type: UnificationXref
id: CHEBI:64039
db: ChEBI

UnificationXref794
type: UnificationXref
id: REACT_5847
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5847.1

UnificationXref1133
type: UnificationXref
id: 389893
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389893

UnificationXref793
type: UnificationXref
id: 113529
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113529

UnificationXref1130
type: UnificationXref
id: 4236242
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236242

UnificationXref792
type: UnificationXref
id: REACT_3202
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3202.1

UnificationXref1131
type: UnificationXref
id: REACT_92361
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92361.9

UnificationXref791
type: UnificationXref
id: 77302
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77302

UnificationXref1136
type: UnificationXref
id: 4234572
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234572

UnificationXref790
type: UnificationXref
id: CHEBI:15491
db: ChEBI

UnificationXref3396
type: UnificationXref
id: 2161185
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161185

UnificationXref1137
type: UnificationXref
id: O06543
db: UniProt

UnificationXref3397
type: UnificationXref
id: REACT_121916
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121916.1

Pyridoxamine phosphate [ChEBI:8670]
type: SmallMoleculeReference
name: Pyridoxamine 5-phosphate
name: Pyridoxamine phosphate
name: Pyridoxamine 5'-phosphate
xref: UnificationXref2401

UnificationXref1134
type: UnificationXref
id: REACT_17371
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17371.1

UnificationXref3398
type: UnificationXref
id: 2161525
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161525

UnificationXref1135
type: UnificationXref
id: O53867
db: UniProt

UnificationXref3399
type: UnificationXref
id: REACT_121861
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121861.1

UnificationXref4283
type: UnificationXref
id: 113681
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113681

Evidence328
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11277919
xref: http://identifiers.org/pubmed/12972261
xref: http://identifiers.org/pubmed/9488696
xref: http://identifiers.org/pubmed/1851158
xref: http://identifiers.org/pubmed/13211603
xref: PublicationXref483
comment: Cytosolic nucleoside diphosphate kinases catalyze the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates with ATP to form the corresponding nucleoside 5'-triphosphates and ADP. These kinases are ubiquitously expressed enzymes with broad substrate specificities (Berg and Joklik 1954; Parks and Agarwal 1973). Three human cytosolic nucleoside diphosphate kinase proteins, NME1, 2, and 3, have been characterized biochemically (Gilles et al. 1991; Schaertl et al. 1998; Erent et al. 2001; Chen et al. 2003). All are catalytically active as hexamers: homohexamers of NME1, 2, and 3 have been described, as have heterohexamers containing all possible combinations of NME1 and 2 (Gilles et al. 1991; Erent et al. 2001). While cytosolic nucleoside diphosphate kinases can efficiently use several nucleotide triphosphates as a phosphate donor, the high concentrations of ATP relative to other nucleoside triphosphates in vivo makes it the likely major phosphate donor in these reactions and only reactions with ATP as the phosphate donor are annotated. All of these phosphorylation reactions are freely reversible in vitro (Parks and Agarwal 1973; Schaertl et al. 1998), but the high ratio of ATP to ADP concentrations in the cytosol should favor the conversion of (d)NDP and ATP to (d)NTP and ADP.

UnificationXref4284
type: UnificationXref
id: REACT_5329
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5329.2

Evidence327
type: Evidence
evidence code: inferred from electronic annotation
comment: In this reaction, 1 molecule of 'Thioredoxin' is translocated from cytosol to nucleoplasm. This movement of the molecule occurs through the 'nuclear pore'.

UnificationXref4285
type: UnificationXref
id: 4234421
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234421

UnificationXref1138
type: UnificationXref
id: 4234575
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234575

http://identifiers.org/pubmed/10202136
type: PublicationXref
id: 10202136
author: Bockaert, J
author: Pin, JP
db: Pubmed
title: Molecular tinkering of G protein-coupled receptors: an evolutionary success
source: EMBO J 18:1723-9
year: 1999

UnificationXref4286
type: UnificationXref
id: REACT_93739
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93739.9

UnificationXref1139
type: UnificationXref
id: 4234576
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234576

Evidence329
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11277919
xref: http://identifiers.org/pubmed/12972261
xref: http://identifiers.org/pubmed/9488696
xref: http://identifiers.org/pubmed/1851158
xref: http://identifiers.org/pubmed/13211603
xref: PublicationXref483
comment: Cytosolic nucleoside diphosphate kinases catalyze the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates with ADP to form the corresponding nucleoside 5'-diphosphates and ATP. These kinases are ubiquitously expressed enzymes with broad substrate specificities (Berg and Joklik 1954; Parks and Agarwal 1973). Three human cytosolic nucleoside diphosphate kinase proteins, NME1, 2, and 3, have been characterized biochemically (Gilles et al. 1991; Schaertl et al. 1998; Erent et al. 2001; Chen et al. 2003). All are catalytically active as hexamers: homohexamers of NME1, 2, and 3 have been described, as have heterohexamers containing all possible combinations of NME1 and 2 (Gilles et al. 1991; Erent et al. 2001). While the high ratio of ATP to ADP concentrations in the cytosol normally favors the conversion of (d)NDP and ATP to (d)NTP and ADP, the reversibility of the reactions and the overlapping substrate specificities of the enzymes suggest that this group of reverse reactions can buffer the intracellular nucleotide pool and regulate the relative concentrations of individual nucleoside di- and tri-phosphates in the pool.

Evidence324
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9677297
xref: http://identifiers.org/pubmed/2668278
xref: http://identifiers.org/pubmed/10884394
xref: http://identifiers.org/pubmed/16373698
xref: http://identifiers.org/pubmed/11796141
xref: http://identifiers.org/pubmed/14729598
comment: Cytosolic ribonucleotide reductase catalyzes the reduction of adenine, guanine, cytidine, and uridine ribonucleoside 5'-diphosphates to form the corresponding deoxyribonucleoside 5'-diphosphates, coupled to the oxidation of thioredoxin (Holmgren 1989; Eklund et al. 2001). Ribonucleotide reductase is a tetramer of two large and two small subunits (Shao et al. 2004; Zhou et al. 2005). The overall activity of the enzyme is regulated allosterically: ATP binding is stimulatory while dATP binding is inhibitory (Reichard et al. 2000). The reducing equivalents needed for ribonucleotide reductase activity can be provided by either of two small proteins, glutaredoxin and thioredoxin (Holmgren 1989; Sun et al. 1998). Both are re-reduced with NADPH as the donor of reducing equivalents, and so are active in catalytic amounts. The relative contributions of glutaredoxin and thioredoxin in vivo are unknown.

UnificationXref4280
type: UnificationXref
id: REACT_89685
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89685.9

Evidence323
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6182143
xref: http://identifiers.org/pubmed/5484814
comment: Mitochondrial adenylate kinase 2 (AK2) catalyzes the reaction of two molecules of ADP to form AMP and ATP (Hamade et al. 1982). Localization of AK2 specifically to the mitochondrial intermembrane space is inferred from studies of the homologous rat enzyme (Criss 1970).

UnificationXref4281
type: UnificationXref
id: 4230386
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230386

Evidence326
type: Evidence
evidence code: inferred from electronic annotation
comment: In this reaction, 1 molecule of 'thioredoxin, oxidized' is translocated from nucleoplasm to cytosol. This movement of the molecule occurs through the 'nuclear pore'.

UnificationXref4282
type: UnificationXref
id: CHEBI:15343
db: ChEBI

Evidence325
type: Evidence
evidence code: inferred from electronic annotation
comment: Deoxyribonucleotides needed for DNA repair are synthesized de novo by the reduction of ribonucleoside 5'-diphosphates. This reaction is catalyzed by a nuclear form of ribonucleotide reductase active throughout the cell cycle. The reducing equivalents needed for these reactions can be provided directly by thioredoxin.

UnificationXref1181
type: UnificationXref
id: 4236245
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236245

UnificationXref796
type: UnificationXref
id: REACT_2390
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2390.1

UnificationXref1182
type: UnificationXref
id: REACT_85187
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85187.9

UnificationXref795
type: UnificationXref
id: 29362
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29362

UnificationXref1183
type: UnificationXref
id: 390404
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390404

UnificationXref798
type: UnificationXref
id: REACT_29078
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29078.10

UnificationXref1184
type: UnificationXref
id: REACT_17976
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17976.2

UnificationXref797
type: UnificationXref
id: 4234209
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234209

Evidence391
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/13416257
comment: Mitochondrial 3-hydroxyisobutyrate dehydrogenase (HIBADH) catalyzes the reversible reaction of methylmalonyl semialdehyde and NADH + H+ to form beta-hydroxyisobutyrate and NAD+. The biochemical properties of human HIBADH are inferred from those of its better-studied porcine homologue (Robinson and Coon 1957). Unpublished crystallographic studies (PDB 2GF2) have shown the active enzyme to be a tetramer of HIBADH polypeptides whose aminoterminal 40 residues, a mitochondrial targeting sequence, have been removed.

UnificationXref799
type: UnificationXref
id: 29374
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29374

Evidence390
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/13416257
comment: Mitochondrial 3-hydroxyisobutyrate dehydrogenase (HIBADH) catalyzes the reversible reaction of beta-hydroxyisobutyrate and NAD+ to form methylmalonyl semialdehyde and NADH + H+. The biochemical properties of human HIBADH are inferred from those of its better-studied porcine homologue (Robinson and Coon 1957). Unpublished crystallographic studies (PDB 2GF2) have shown the active enzyme to be a tetramer of HIBADH polypeptides whose aminoterminal 40 residues, a mitochondrial targeting sequence, have been removed.

UnificationXref1180
type: UnificationXref
id: REACT_113055
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113055.8

UnificationXref4256
type: UnificationXref
id: MOD:00239
db: MOD

Evidence395
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15274622
xref: http://identifiers.org/pubmed/18775954
comment: Mitochondrial glutaryl-CoA dehydrogenase (GCDH) catalyzes the reaction of glutaryl-CoA and FAD to form crotonyl-CoA, FADH2, and CO2. The active enzyme is a tetramer of GCDH polypeptides lacking a 44-residue aminoterminal mitochondrial targeting sequence. Mutations in GCDH cause glutaric aciduria type 1 in vivo (Fu et al. 2004; Keyser et al. 2008).

UnificationXref4257
type: UnificationXref
id: 4234002
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234002

Evidence394
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19885858
xref: http://identifiers.org/pubmed/16491085
comment: Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) catalyzes the reaction of alpha-aminoadipic semialdehyde and NAD+ to form alpha-aminoadipate and NADH + H+ (Mills et al. 2006). Unpublished crystallographic data (PDB 2J6L) indicate that the enzyme is a homodimer. Recent immunofluorescence studies of both endogenous and GFP-tagged ALDH7A1 proteins in cultured human embryonic kidney cells indicate that the protein is present in both mitochondria and the cytosol (Wong et al. 2010).

UnificationXref4254
type: UnificationXref
id: 4234000
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234000

Evidence393
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref547
xref: PublicationXref569
comment: The branched-chain amino acids, leucine, isoleucine, and valine, are all essential amino acids (i.e., ones required in the diet). They are major constituents of muscle protein. The breakdown of these amino acids starts with two common steps catalyzed by enzymes that act on all three amino acids: reversible transamination by branched-chain amino acid aminotransferase, and irreversible oxidative decarboxylation by the branched-chain ketoacid dehydrogenase complex. Isovaleryl-CoA is produced from leucine by these two reactions, alpha-methylbutyryl-CoA from isoleucine, and isobutyryl-CoA from valine. These acyl-CoA's undergo dehydrogenation, catalyzed by three different but related enzymes, and the breakdown pathways then diverge. Leucine is ultimately converted to acetyl-CoA and acetoacetate; isoleucine to acetyl-CoA and succinyl-CoA; and valine to succinyl-CoA. Under fasting conditions, substantial amounts of all three amino acids are generated by protein breakdown. In muscle, the final products of leucine, isoleucine, and valine catabolism can be fully oxidized via the citric acid cycle; in liver they can be directed toward the synthesis of ketone bodies (acetoacetate and acetyl-CoA) and glucose (succinyl-CoA) (Chuang & Shih 2001, Sweetman & Williams 2001).

UnificationXref4255
type: UnificationXref
id: 4230218
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230218

Evidence392
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/1527093
xref: http://identifiers.org/pubmed/10947204
comment: Mitochondrial methylmalonate semialdehyde dehydrogenase (ALDH6A1) catalyzes the reaction of methylmalonate semialdehyde, NAD+, and CoA to form propionyl-CoA, CO2, and NADH + H+. A human ALDH6A1 gene has been cloned. Its sequence is closely homologous to that of the better-characterized rat enzyme (Kedishvili et al. 1992) and a missense mutation in a normally well-conserved codon has been found in the allele of the gene from a patient with a defect in methylmalonic semialdehyde dehydrogenase activity (Chambliss et al. 2000).

Evidence399
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref578
xref: PublicationXref579
comment: The first reaction in this pathway converts phenylalanine to tyrosine, coupled to the conversion of tetrahydrobiopterin to 4a-hydroxytetrahydrobiopterin, catalyzed by phenylalanine hydroxylase. (Deficiencies in this enzyme are responsible for the commonest form of phenylketonuria (PKU) in humans.) This reaction functions both as the first step in the pathway by which the body disposes of excess phenylalanine, and as a source of the amino acid tyrosine. The next two reactions are responsible for the regeneration of tetrahydrobiopterin from 4a-hydroxytetrahydrobiopterin. The following five reactions convert tyrosine to fumarate, an intermediate in the citric acid cycle, and acetoacetate, a ketone body.

Evidence398
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref578
comment: Cytosolic tyrosine aminotransferase (TAT) catalyzes the reversible reaction of 3-(4-hydroxyphenyl)pyruvate and glutamate to form tyrosine and alpha-keto (2-oxo) glutarate (Mitchell et al. 2001). The enzymatic activity of the protein encoded by the cloned human TAT cDNA is inferred from the biochemical properties of its rat homologue. Unpublished crystallographic studies (PDB 3DYD) have shown TAT to be a homodimer with a pyridoxal phosphate moity attached to lysine-280 in each monomer.

UnificationXref4258
type: UnificationXref
id: 4234004
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234004

Evidence397
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref578
comment: Cytosolic tyrosine aminotransferase (TAT) catalyzes the reversible reaction of tyrosine and alpha-keto (2-oxo) glutarate to form 3-(4-hydroxyphenyl)pyruvate and glutamate (Mitchell et al. 2001). The enzymatic activity of the protein encoded by the cloned human TAT cDNA is inferred from the biochemical properties of its rat homologue. Unpublished crystallographic studies (PDB 3DYD) have shown TAT to be a homodimer with a pyridoxal phosphate moity attached to lysine-280 in each monomer.

UnificationXref4259
type: UnificationXref
id: REACT_29167
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29167.10

Evidence396
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref575
xref: http://identifiers.org/pubmed/12126930
xref: http://identifiers.org/pubmed/6434529
xref: PublicationXref577
comment: In humans, most catabolism of L-lysine normally proceeds via a sequence of seven reactions which feeds into the pathway for fatty acid catabolism. In the first two reactions, catalyzed by a single enzyme complex, lysine is combined with alpha-ketoglutarate to form saccharopine, which in turn is cleaved and oxidized to yield glutamate and alpha-ketoadipic semialdehyde. The latter molecule is further oxidized to alpha-ketoadipate. Alpha-ketoadipate is oxidatively decarboxylated by the alpha-ketoglutarate dehydrogenase complex (the same enzyme complex responsible for the conversion of alpha-ketoglutarate to succinyl-CoA in the citric acid cycle), yielding glutaryl-CoA. Glutaryl-CoA is converted to crotonyl-CoA, crotonyl-CoA is converted to beta-hydroxybutyryl-CoA, and beta-hydroxybutyryl-CoA is converted to acetoacetyl-CoA. The products of lysine catabolism are thus exclusively ketogenic; i.e., under starvation conditions they can be used for the synthesis of ketone bodies, beta-hydroxybutyrate and acetoacetate, but not for the net synthesis of glucose (Cox 2001; Goodman and Freeman 2001).

UnificationXref4253
type: UnificationXref
id: P0A696
db: UniProt

UnificationXref4252
type: UnificationXref
id: 4230214
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230214

UnificationXref4251
type: UnificationXref
id: REACT_29470
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29470.10

UnificationXref4250
type: UnificationXref
id: 4236142
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236142

UnificationXref1189
type: UnificationXref
id: REACT_17592
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17592.1

5-phosphoribosylglycinamide [ChEBI:18349]
type: SmallMoleculeReference
name: Glycinamide ribonucleotide
name: GAR
name: 5-phosphoribosylglycinamide
name: N1-(5-Phospho-D-ribosyl)glycinamide
xref: UnificationXref1875

UnificationXref1186
type: UnificationXref
id: REACT_18126
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18126.2

UnificationXref1185
type: UnificationXref
id: 390426
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390426

UnificationXref1188
type: UnificationXref
id: 390419
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390419

UnificationXref1187
type: UnificationXref
id: CHEBI:17868
db: ChEBI

UnificationXref1194
type: UnificationXref
id: O05784
db: UniProt

UnificationXref1195
type: UnificationXref
id: 4234146
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234146

UnificationXref1192
type: UnificationXref
id: O53525
db: UniProt

UnificationXref1193
type: UnificationXref
id: 4234143
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234143

UnificationXref1190
type: UnificationXref
id: 141335
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=141335

UnificationXref1191
type: UnificationXref
id: REACT_5013
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5013.1

Evidence380
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/7918575
xref: PublicationXref547
xref: http://identifiers.org/pubmed/15946682
xref: http://identifiers.org/pubmed/10745006
xref: http://identifiers.org/pubmed/11839747
xref: http://identifiers.org/pubmed/2188967
comment: The mitochondrial nranched-chain alpha-ketoacid dehydrogenase (BKCD) complex catalyzes the reactions of alpha-ketoisocaproate, alpha-keto beta-methylvalerate, or aalpha-ketoisovalerate with CoA and NAD+ to form isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA, respectively, and CO2 and NADH (Chuang and Shih 2001). While bovine and microbial BCKD complexes have been characterized most extensively (Reed and Hackert 1990), structural studies of individual components and subcomplexes of human BKCD have confirmed their structures and roles in the overall oxidative carboxylation process, and have related these features to the disruptive effects of mutations on branched-chain amino acid metabolism in vivo: E1a and E1b components - AEvarsson et al. 2000; E2 - Chang et al. 2002; E3- Brautigam et al. 2005. In addition, structural studies have confirmed the lipoylation of lysine residue 44 in E2 protein (Chang et al. 2002) and the loss of an aminoterminal mitochondrial transport sequence from mature E3 protein (Bruatigam et al. 2005). Loss of mitochondrial transport sequences from proteins E1a, E1b, and E2 has been domstrated by sequence analysis (Wynn et al. 1999).

http://identifiers.org/pubmed/19234479
type: PublicationXref
id: 19234479
author: Johnson, E
author: Lewinson, O
author: Rees, DC
db: Pubmed
title: ABC transporters: the power to change
source: Nat Rev Mol Cell Biol 10:218-27
year: 2009

UnificationXref4265
type: UnificationXref
id: 159942
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159942

Evidence382
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11181649
xref: http://identifiers.org/pubmed/11406611
xref: http://identifiers.org/pubmed/7356336
xref: http://identifiers.org/pubmed/16023992
comment: Methylcrotonyl CoA carboxylase (MCCA) catalyzes the reversible reaction of beta-methylcrotonyl-CoA, ATP, and CO2 to form beta-methylglutaconyl-CoA, ADP, orthophosphate, and H2O. Active MCCA is composed of two polypeptides, MCCA1 and MCCA2 (Baumgartner et al. 2001; Holzinger et al. 2001). The enzyme has been purified from fibroblast mitochondria. By analogy to the more thoroughly studied bovine homologue, MCCA is thought to be a hexamer of six MCCA1:MCCA2 dimers, and the MCCA1 polypeptide is thought to have a biotin moiety covalently bound to lysine residue 681. Localization of the complex to the mitochondrial inner membrane is inferred from studies of the bovine homologue (Hector et al. 1980). Mitochondrial import of MCCA1 and 2 is associated with removal of aminoterminal mitochondrial targeting sequences (Stadler et al. 2005).

UnificationXref4266
type: UnificationXref
id: REACT_3041
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3041.1

Evidence381
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3597357
xref: http://identifiers.org/pubmed/9214289
xref: http://identifiers.org/pubmed/6928646
comment: Mitochondrial isovaleryl dehydrogenase (IVD) catalyzes the reaction of isovaleryl-CoA and FAD to form beta-methylcrotonyl-CoA and FADH2 (Finocchiaro et al. 1978; Rhead and Tanaka 1980). Crystallographic studies demonstrated the existene of a tetramer of IVD polypeptides lacking an aminoterminal mitochondrial targeting sequence (Tiffany et al. 1997).

UnificationXref4267
type: UnificationXref
id: CHEBI:16842
db: ChEBI

Evidence384
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11013134
xref: http://identifiers.org/pubmed/10832746
comment: Mitochondrial 2-methyl branched chain acyl-CoA dehydrogenase (ACADSB) catalyzes the reaction of alpha-methylbutyryl-CoA and FAD to form 'tiglyl-CoA and FADH2 (Andresen et al. 2000; Gibson et al. 2000). Unpublished crystallographic data (PDB 2JIF) indicate that the enzyme is a tetramer of ACADSB polypeptides whose aminoterminal 51 residues, a mitochondrial targeting sequence, have been removed.

UnificationXref4268
type: UnificationXref
id: 29478
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29478

Evidence383
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11181649
xref: http://identifiers.org/pubmed/11406611
comment: Methylcrotonyl CoA carboxylase (MCCA) catalyzes the reversible reaction of beta-methylglutaconyl-CoA, ADP, orthophosphate, and H2O to form beta-methylcrotonyl-CoA, ATP, and CO2. Active MCCA is composed of two polypeptides, MCCA1 and MCCA2 (Baumgartner et al. 2001; Holzinger et al. 2001). The enzyme has been purified from fibroblast mitochondria. By analogy to the more thoroughly studied bovine homologue, MCCA is thought to be a hexamer of six MCCA1:MCCA2 dimers, and the MCCA1 polypeptides are thought to have biotin moieties covalently bound to a lysine residue at position 681 in the polypeptide chain. Mitochondrial import of MCCA1 and 2 is associated with removal of aminoterminal mitochondrial targeting sequences but the exact lengths of these sequences have not been determined.

UnificationXref4269
type: UnificationXref
id: REACT_4272
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4272.3

Evidence386
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12696021
xref: http://identifiers.org/pubmed/15342248
comment: Mitochondrial 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10; HADH2) catalyzes the reversible reaction of alpha-methylacetoacetyl-CoA and NADH + H+ to form alpha-methyl-beta-hydroxybutyryl-CoA and NAD+ (Ofman et al. 2003). Crystallographic data indicate that the enzyme is a homotetramer (Kissinger et al. 2004).

Evidence385
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12696021
xref: http://identifiers.org/pubmed/15342248
comment: Mitochondrial 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10; HADH2) catalyzes the reversible reaction of alpha-methyl-beta-hydroxybutyryl-CoA and NAD+ to form alpha-methylacetoacetyl-CoA and NADH + H+ (Ofman et al. 2003). Crystallographic data indicate that the enzyme is a homotetramer (Kissinger et al. 2004).

http://identifiers.org/pubmed/6788990
type: PublicationXref
id: 6788990
author: Kamijo, K
author: Kobayashi, S
author: Oguchi, K
author: Uesato, T
db: Pubmed
title: Studies on beta-phenylethylamine deamination by human placental monoamine oxidase
source: Jpn J Pharmacol 31:7-14
year: 1981

Evidence388
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9889013
xref: http://identifiers.org/pubmed/14752098
xref: http://identifiers.org/pubmed/12359132
comment: Mitochondrial isobutyryl-CoA dehydrogenase (ACAD8) catalyzes the reaction of isobutyryl-CoA and FAD to form methacrylyl-CoA and FADH2 (Roe et al. 1999; Nguyen et al. 2002). Crystallographic studies have shown the active enzyme to be a tetramer of ACAD8 polypeptides whose aminoterminal 23 residues, a mitochondrial targeting sequence, have been removed (Bataille et al. 2004).

Evidence387
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17371050
comment: Mitochondrial acetyl-CoA acetyltransferase (ACAT1) catalyzes the reaction of alpha-methyl-acetoacetyl-CoA and CoA to form propionyl-CoA and acetyl-CoA. Structural studies have shown the active enzyme to be a tetramer of ACAT1 polypeptides whose aminoterminal 34 residues, a mitochondrial targeting sequence, have been removed (Haapalainen et al. 2007).

Evidence389
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8824301
comment: Mitochondrial 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) catalyzes the hydrolysis of beta-hydroxyisobutyryl-CoA to form beta-hydroxyisobutyrate (3-hydroxy-2-methylpropanoate) and CoA (Hawes et al. 1996).

UnificationXref4260
type: UnificationXref
id: 113671
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113671

UnificationXref4262
type: UnificationXref
id: 113685
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113685

UnificationXref4261
type: UnificationXref
id: REACT_4221
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4221.2

UnificationXref4264
type: UnificationXref
id: 4230383
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230383

UnificationXref4263
type: UnificationXref
id: REACT_4226
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4226.2

Norepinephrine
type: SmallMoleculeReference
name: Arterenol
name: LEVOPHED (TN)
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol [ChEBI:1]
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol
name: L-Noradrenaline
name: Noradrenaline
xref: UnificationXref3613

UnificationXref1199
type: UnificationXref
id: 4234139
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234139

UnificationXref1198
type: UnificationXref
id: 4234136
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234136

UnificationXref1197
type: UnificationXref
id: 4234148
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234148

UnificationXref1196
type: UnificationXref
id: 4234147
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234147

UnificationXref1160
type: UnificationXref
id: 390305
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390305

UnificationXref1161
type: UnificationXref
id: REACT_17568
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17568.2

UnificationXref1162
type: UnificationXref
id: O06135
db: UniProt

trans-Dec-2-enoyl-CoA
type: SmallMoleculeReference
name: trans-Dec-2-enoyl-CoA [ChEBI:10723]
xref: UnificationXref856

UnificationXref4238
type: UnificationXref
id: 4234317
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234317

Evidence377
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9188776
comment: Dephosphorylation of O-phospho-L-serine to L-serine proceeds through a phospho-enzyme intermediate of the catalysing phosphatase PSP (Collet et al. 1997).

UnificationXref4239
type: UnificationXref
id: 4234318
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234318

Evidence376
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19235232
comment: Serine biosynthesis starts from 3-phosphoglycerate, a glycolysis intermediate. Its dehydrogenation is catalysed by tetrameric phosphoglycerate dehydrogenase PHGDH. (Tabatabaie et al. 2009).

UnificationXref4236
type: UnificationXref
id: 4234315
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234315

Evidence375
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2564390
comment: Cytosolic asparagine synthase (ASNS) catalyzes the reaction of aspartate, glutamine, and ATP to form asparagine, glutamate, AMP, and pyrophosphate. Studies of the recombinant protein expressed in E. coli suggest that the active form of the enzyme is a dimer (Van Heeke and Schuster 1989).

Gap-filling DNA repair synthesis and ligation in TC-NER
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction365
evidence: Evidence652
xref: UnificationXref4327
xref: UnificationXref4328
pathway order: PathwayStep638
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref4237
type: UnificationXref
id: 4234316
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234316

Evidence374
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10037775
comment: Delta-1-pyrroline-5-carboxylate synthetase associated with the inner mitochondrial membrane catalyzes the two-step reaction that converts glutamate, ATP, and NADPH + H+ to L-glutamate gamma-semialdehyde, NADP+, ADP, and orthophosphate. Two P5CS isoforms have been identified; both are active when expressed in enzyme-deficient cells in culture (Hu et al. 1999). Unpublished crystallographic data (PDB 2H5G) indicate that the enzyme is a dimer.

UnificationXref4234
type: UnificationXref
id: REACT_89350
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89350.9

Evidence373
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref537
xref: http://identifiers.org/pubmed/1737786
comment: Mitochondrial ornithine aminotransferase (OAT) catalyzes the reversible reaction of glutamate semialdehyde and glutamate to form ornithine and alpha-ketoglutarate (Ohura et al. 1982). The active enzyme is a hexamer (Shen et al. 1998). Inherited OAT deficiency leads to ornithine accumulation in vivo and gyrate atrophy of the choroid and retina (Brody et al. 1992; Vallee and Simell 2001).

UnificationXref4235
type: UnificationXref
id: 4234314
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234314

Evidence372
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6819292
xref: PublicationXref537
xref: http://identifiers.org/pubmed/1737786
xref: http://identifiers.org/pubmed/9514741
comment: Mitochondrial ornithine aminotransferase (OAT) catalyzes the reversible reaction of ornithine and alpha-ketoglutarate to form glutamate semialdehyde and glutamate (Ohura et al. 1982). The active enzyme is a hexamer (Shen et al. 1998). Inherited OAT deficiency leads to ornithine accumulation in vivo and gyrate atrophy of the choroid and retina (Brody et al. 1992; Valle and Simell 2001).

UnificationXref4232
type: UnificationXref
id: REACT_79568
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79568.9

Evidence371
type: Evidence
evidence code: inferred from electronic annotation
comment: Vitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only in limited amounts by human cells. Vitamins are classified according to their solubility, either fat-soluble or water-soluble. The physiological processes dependent on vitamin-requiring reactions include many aspects of intermediary metabolism, vision, bone formation, and blood coagulation, and vitamin deficiencies are associated with a correspondingly diverse and severe group of diseases. The metabolism of water-soluble vitamins and of vitamin D are annotated in Reactome.

UnificationXref4233
type: UnificationXref
id: 4236140
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236140

Evidence370
type: Evidence
evidence code: inferred from electronic annotation
comment: Vitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only in limited amounts by human cells. Vitamins are classified according to their solubility, either fat-soluble or water-soluble. The physiological processes dependent on vitamin-requiring reactions include many aspects of intermediary metabolism, vision, bone formation, and blood coagulation, and vitamin deficiencies are associated with a correspondingly diverse and severe group of diseases. Water-soluble vitamins include ascorbate (vitamin C) and the members of the B group: thiamin (vitamin B1), riboflavin (B2), niacin (B3), pantothenate (B5), pyridoxine (B6), biotin (B7), folate (B9), and cobalamin (B12). Metabolic processes annotated here include the synthesis of thiamin pyrophosphate (TPP) from thiamin (B1), the synthesis of FMN and FAD from riboflavin (B2), the synthesis of nicotinic acid (niacin - B3) from tryptophan, the synthesis of Coenzyme A from pantothenate (B5), and features of the metabolism of folate (B9).

UnificationXref4231
type: UnificationXref
id: 4234313
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234313

UnificationXref4230
type: UnificationXref
id: 4234311
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234311

Evidence378
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15021249
comment: L-Serine is needed in human brain in large amounts as precursor to important biomolecules such as nucleotides, phospholipids and the neurotransmitters glycine and D-serine. The pathway for its synthesis starts with 3-phosphoglycerate and it later needs glutamate as an amination agent. Deficiencies in the participating enzymes lead to severe neurological symptoms that are treatable with serine if treatment starts early (de Koning & Klomp 2004).

Evidence379
type: Evidence
evidence code: inferred from electronic annotation
comment: These reactions mediate the synthesis of aspartate, asparagine, glutamate, and glutamine from ammonia and intermediates of glycolysis, and allow the utilization of the carbon atoms from these four amino acids for glucose synthesis under fasting conditions. These reactions also provide a means to collect nitrogen, both as ammonia and as amino groups, and direct it towards urea synthesis. Transamination, the conversion of an amino acid to the corresponding alpha-keto acid coupled to the conversion of a molecule of alpha-ketoglutarate to glutamate, is the first step in the catabolism of most amino acids. Transamination reactions are freely reversible so they also provide a means to balance concentrations of various amino acids and alpha-keto (2-oxo) acids in the cytosol.

UnificationXref1164
type: UnificationXref
id: O06209
db: UniProt

UnificationXref1163
type: UnificationXref
id: 4234626
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234626

UnificationXref1166
type: UnificationXref
id: 4234630
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234630

UnificationXref1165
type: UnificationXref
id: 4234629
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234629

Phosphate
type: SmallMoleculeReference
name: Orthophosphate
name: Orthophosphate [ChEBI:18367]
name: Inorganic Phosphate
xref: UnificationXref256

UnificationXref1168
type: UnificationXref
id: REACT_83459
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83459.9

UnificationXref1167
type: UnificationXref
id: 4235024
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235024

http://identifiers.org/pubmed/8120105
type: PublicationXref
id: 8120105
author: Apfelroth, S D
author: Zhang, H
author: Ramirez, F
author: Hu, W
author: Mecham, R P
author: Bonadio, J
author: Davis, E C
author: Sanguineti, C
db: Pubmed
title: Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices
source: J. Cell Biol. 124:855-63
year: 1994

UnificationXref1169
type: UnificationXref
id: 4236244
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236244

UnificationXref1172
type: UnificationXref
id: 390394
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390394

UnificationXref1173
type: UnificationXref
id: REACT_17364
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17364.2

UnificationXref1170
type: UnificationXref
id: REACT_85716
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85716.9

UnificationXref1171
type: UnificationXref
id: CHEBI:52966
db: ChEBI

UnificationXref4247
type: UnificationXref
id: REACT_34246
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34246.10

Evidence364
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3871768
xref: http://identifiers.org/pubmed/3053686
comment: The methylenetetrahydrofolate dehydrogenase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 5,10-methyleneTHF polyglutamate and NADP+ to form 5,10-methenylTHF polyglutamate, NADPH, and H+. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

UnificationXref4248
type: UnificationXref
id: 4236141
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236141

Evidence363
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9753690
comment: Cytosolic serine hydroxymethyltransferase catalyzes the reversible reaction of 5,10-methyleneTHF polyglutamate and glycine to form tetrahydrofolate polyglutamate (THF polyglutamate) and serine. The active form of the enzyme is a tetramer (Renwick et al. 1998).

UnificationXref4249
type: UnificationXref
id: REACT_107349
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107349.9

Evidence366
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10466189
xref: http://identifiers.org/pubmed/11001804
comment: Folates are essential cofactors that provide one-carbon moieties in various states of reduction for biosynthetic reactions. Processes annotated here include transport reactions by which folates are taken up by cells and moved intracellularly, folate conjugation with glutamate (required for folate retention within a cell), and some of the key reactions in the generation of reduced folates and one-carbon derivatives of folate.

Evidence365
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3871768
xref: http://identifiers.org/pubmed/3053686
comment: The methenyltetrahydrofolate cyclohydrolase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 5,10-methenylTHF polyglutamate and H2O to form 10-formylTHF polyglutamate. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

UnificationXref4243
type: UnificationXref
id: REACT_81807
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81807.9

Evidence360
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3871768
xref: http://identifiers.org/pubmed/3053686
comment: The methenyltetrahydrofolate cyclohydrolase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 10-formylTHF polyglutamate to form 5,10-methenylTHF polyglutamate and H2O. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

UnificationXref4244
type: UnificationXref
id: 4234324
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234324

UnificationXref4245
type: UnificationXref
id: REACT_80499
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80499.9

Evidence362
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9753690
comment: Cytosolic serine hydroxymethyltransferase catalyzes the reversible reaction of tetrahydrofolate polyglutamate (THF polyglutamate) and serine to form 5,10-methyleneTHF polyglutamate and glycine. The active form of the enzyme is a tetramer (Renwick et al. 1998). In the body, this reaction is a major source of 5,10-methyleneTHF, which in turn is a critical precursor in the synthesis of dTMP.

UnificationXref4246
type: UnificationXref
id: 4236143
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236143

Evidence361
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3871768
xref: http://identifiers.org/pubmed/3053686
comment: The methylenetetrahydrofolate dehydrogenase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 5,10-methenylTHF polyglutamate, NADPH, and H+ to form 5,10-methyleneTHF polyglutamate and NADP+. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

6-(L-erythro-1,2-Dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
type: SmallMoleculeReference
name: 7,8-dihydroneopterin 3'-triphosphate [ChEBI:18372]
name: 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin
name: 6-(L-erythro-1,2-dihydroxy-3-triphosphooxypropyl)-7,8-dihydropterin
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
name: 7,8-dihydroneopterin 3'-triphosphate
xref: UnificationXref1751

UnificationXref4240
type: UnificationXref
id: 4234319
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234319

UnificationXref4242
type: UnificationXref
id: 4234322
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234322

UnificationXref4241
type: UnificationXref
id: 4234320
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234320

Evidence367
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15180982
xref: http://identifiers.org/pubmed/11891227
comment: GTP cyclizes in a reaction involving radicals of S-adenosylmethionine, catalyzed by the iron-sulfur cluster dimeric MOCS1. The intermediate result is called precursor Z (Hanzelmann et al, 2002; Hanzelmann et al, 2004).

Evidence368
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12732628
xref: http://identifiers.org/pubmed/12571226
comment: After the MOCS2A dimer is loaded with two sulfur atoms, their sequential deposition on the precursor Z molecule, with ring cleavage, is catalyzed by the MOCS2B half of the MOCS2 tetramer (Leimkuhler et al, 2003; Wuebbens & Rajagopalan, 2002).

Evidence369
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19675644
xref: http://identifiers.org/pubmed/16261263
comment: Molybdenum cofactor (MoCo) is needed by three enzymes in humans: sulfite oxidase, xanthine oxidase and aldehyde oxidase. The pathway of its synthesis is so conserved that plants and bacteria can readily use human enzymes. Bacteria, however, diverge after the first three steps from this path and their final MoCo differs from that of the eukaryotes. Plants and animals have also developed a refinement of their MoCo which is needed for the function of their xanthine and aldehyde oxidases. This means, in humans we find sulfurated instead of desulfurated molybdenum cofactor on these two enzymes (Schwarz 2005; Schwarz, Mendel, Ribbe 2009).

UnificationXref1177
type: UnificationXref
id: 4234973
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234973

UnificationXref1176
type: UnificationXref
id: Q50614
db: UniProt

UnificationXref1175
type: UnificationXref
id: REACT_17913
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17913.2

UnificationXref1174
type: UnificationXref
id: 390260
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390260

UnificationXref1179
type: UnificationXref
id: 4235026
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235026

UnificationXref1178
type: UnificationXref
id: 4234974
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234974

UnificationXref2202
type: UnificationXref
id: REACT_32174
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32174.10

UnificationXref3336
type: UnificationXref
id: 4235440
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235440

UnificationXref2201
type: UnificationXref
id: 4236088
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236088

UnificationXref3337
type: UnificationXref
id: REACT_137525
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137525.5

UnificationXref2204
type: UnificationXref
id: 4234255
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234255

UnificationXref3334
type: UnificationXref
id: 4235436
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235436

Ammonia
type: SmallMoleculeReference
name: NH3 [ChEBI:16134]
name: NH3
xref: UnificationXref1982

UnificationXref2203
type: UnificationXref
id: P69440
db: UniProt

UnificationXref3335
type: UnificationXref
id: 4235437
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235437

UnificationXref3332
type: UnificationXref
id: REACT_75968
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_75968.2

Hydrogen sulfide [ChEBI:5787]
type: SmallMoleculeReference
name: H2S
name: Hydrogen-sulfide
name: Hydrogen sulfide
xref: UnificationXref2999

UnificationXref3333
type: UnificationXref
id: O53356
db: UniProt

UnificationXref2200
type: UnificationXref
id: REACT_100843
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100843.9

UnificationXref3330
type: UnificationXref
id: CHEBI:18183
db: ChEBI

UnificationXref3331
type: UnificationXref
id: 1247942
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1247942

2-Phenylethylamine [ChEBI:18397]
type: SmallMoleculeReference
name: 2-Phenylethylamine
xref: UnificationXref3218

UnificationXref4220
type: UnificationXref
id: P63987
db: UniProt

UnificationXref2209
type: UnificationXref
id: Q7D8E1
db: UniProt

http://identifiers.org/pubmed/9278442
type: PublicationXref
id: 9278442
author: Shiba, K
author: Musier-Forsyth, K
author: Stello, T
author: Noda, T
author: Motegi, H
author: Schimmel, P
db: Pubmed
title: Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant
source: J Biol Chem 272:22809-16
year: 1997

UnificationXref2206
type: UnificationXref
id: REACT_153437
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153437.3

UnificationXref2205
type: UnificationXref
id: 4234258
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234258

UnificationXref2208
type: UnificationXref
id: REACT_154529
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154529.3

UnificationXref3338
type: UnificationXref
id: CHEBI:24190
db: ChEBI

UnificationXref2207
type: UnificationXref
id: 4234257
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234257

UnificationXref3339
type: UnificationXref
id: 1247943
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1247943

http://identifiers.org/pubmed/14699511
type: PublicationXref
id: 14699511
author: Meier, PJ
author: Kullak-Ublick, GA
author: Stieger, B
db: Pubmed
title: Enterohepatic bile salt transporters in normal physiology and liver disease
source: Gastroenterology 126:322-42
year: 2004

UnificationXref4228
type: UnificationXref
id: 4234310
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234310

UnificationXref4227
type: UnificationXref
id: 4234308
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234308

http://identifiers.org/pubmed/8806705
type: PublicationXref
id: 8806705
author: Poulter, CD
author: Hahn, FM
author: Chambers, AF
author: Xuan, JW
db: Pubmed
title: Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization
source: Arch Biochem Biophys 332:30-4
year: 1996

UnificationXref4226
type: UnificationXref
id: 4234307
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234307

UnificationXref4225
type: UnificationXref
id: REACT_100641
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100641.9

UnificationXref4224
type: UnificationXref
id: 4234306
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234306

UnificationXref4223
type: UnificationXref
id: 4234305
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234305

UnificationXref4222
type: UnificationXref
id: 4234304
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234304

UnificationXref4221
type: UnificationXref
id: 4234303
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234303

http://identifiers.org/pubmed/3722183
type: PublicationXref
id: 3722183
author: Fessler, JH
author: Doege, KJ
db: Pubmed
title: Folding of carboxyl domain and assembly of procollagen I
source: J Biol Chem 261:8924-35
year: 1986

UniProt:O65933
type: ProteinReference
xref: UnificationXref671
organism: BioSource1

UniProt:O65934
type: ProteinReference
xref: UnificationXref618
organism: BioSource1

UnificationXref4229
type: UnificationXref
id: REACT_87801
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87801.9

UnificationXref3323
type: UnificationXref
id: 4234512
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234512

UnificationXref3324
type: UnificationXref
id: REACT_101180
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101180.9

UnificationXref3325
type: UnificationXref
id: 4236197
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236197

UnificationXref3326
type: UnificationXref
id: REACT_93357
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93357.9

UnificationXref3320
type: UnificationXref
id: REACT_7059
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7059.1

UnificationXref3321
type: UnificationXref
id: O33202
db: UniProt

Hexadecanol [ChEBI:5696]
type: SmallMoleculeReference
name: 16-Hexadecanol
name: 1-Hexadecanol
name: Palmityl alcohol
name: Cetyl alcohol
name: Hexadecanol
xref: UnificationXref1204

UnificationXref3322
type: UnificationXref
id: 4234510
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234510

myo-Inositol 4-phosphate [ChEBI:10602]
type: SmallMoleculeReference
name: Inositol 4-phosphate
name: 1D-myo-Inositol 4-phosphate
name: D-myo-Inositol 4-phosphate
name: myo-Inositol 4-phosphate
name: 1D-myo-Inositol 4-monophosphate
xref: UnificationXref506

UnificationXref3327
type: UnificationXref
id: CHEBI:17515
db: ChEBI

UnificationXref3328
type: UnificationXref
id: 174393
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174393

http://identifiers.org/pubmed/14763976
type: PublicationXref
id: 14763976
author: Russell, DG
author: Smith, DA
author: McAlister, MS
author: Kendall, SL
author: Bancroft, GJ
author: Norman, RA
author: Dinadayala, P
author: Rison, SC
author: Daffé, M
author: Stoker, NG
author: Murray-Rust, J
author: McDonald, NQ
author: Movahedzadeh, F
author: Av-Gay, Y
db: Pubmed
title: The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence
source: Mol Microbiol 51:1003-14
year: 2004

UnificationXref3329
type: UnificationXref
id: REACT_7046
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7046.2

5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide
type: SmallMoleculeReference
name: ChEBI:18381 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide
xref: UnificationXref1919

UnificationXref4215
type: UnificationXref
id: 4236135
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236135

UnificationXref4214
type: UnificationXref
id: REACT_81409
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81409.9

UnificationXref4217
type: UnificationXref
id: 4230307
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230307

UnificationXref4216
type: UnificationXref
id: REACT_77714
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77714.9

UnificationXref4211
type: UnificationXref
id: 4236133
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236133

UnificationXref4210
type: UnificationXref
id: REACT_108611
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108611.9

UnificationXref4213
type: UnificationXref
id: 4236134
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236134

UnificationXref4212
type: UnificationXref
id: REACT_28306
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28306.10

UnificationXref4219
type: UnificationXref
id: 4234300
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234300

UnificationXref4218
type: UnificationXref
id: P63985
db: UniProt

UnificationXref3310
type: UnificationXref
id: REACT_7422
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7422.1

(-)-3-dehydroquinate
type: SmallMoleculeReference
name: 3-dehydroquinate
name: 5-Dehydroquinate
name: 3-dehydroquinate [ChEBI:32364]
xref: UnificationXref5321

UnificationXref3311
type: UnificationXref
id: 4234507
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234507

UnificationXref3314
type: UnificationXref
id: REACT_83877
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83877.9

UnificationXref3315
type: UnificationXref
id: CHEBI:36062
db: ChEBI

UnificationXref3312
type: UnificationXref
id: REACT_29504
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29504.10

UnificationXref3313
type: UnificationXref
id: 4236185
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236185

UnificationXref3318
type: UnificationXref
id: CHEBI:63797
db: ChEBI

UnificationXref3319
type: UnificationXref
id: 175978
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=175978

UnificationXref3316
type: UnificationXref
id: 175977
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=175977

UnificationXref3317
type: UnificationXref
id: REACT_7596
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7596.1

UnificationXref4202
type: UnificationXref
id: 4234274
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234274

UnificationXref704
type: UnificationXref
id: 4234133
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234133

UnificationXref4201
type: UnificationXref
id: REACT_3731
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3731.1

UnificationXref705
type: UnificationXref
id: REACT_152723
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152723.3

UnificationXref4200
type: UnificationXref
id: 30140
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30140

UnificationXref706
type: UnificationXref
id: CHEBI:50571
db: ChEBI

UnificationXref707
type: UnificationXref
id: 548812
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=548812

UnificationXref4206
type: UnificationXref
id: REACT_4993
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4993.2

UnificationXref708
type: UnificationXref
id: REACT_22457
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22457.1

UnificationXref4205
type: UnificationXref
id: 110228
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110228

UnificationXref709
type: UnificationXref
id: CHEBI:50583
db: ChEBI

http://identifiers.org/pubmed/8752212
type: PublicationXref
id: 8752212
author: Hubbard, SR
author: Schlessinger, J
author: Mohammadi, M
db: Pubmed
title: Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism
source: Cell 86:577-87
year: 1996

UnificationXref4204
type: UnificationXref
id: CHEBI:35877
db: ChEBI

UnificationXref4203
type: UnificationXref
id: REACT_108860
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108860.9

UnificationXref4209
type: UnificationXref
id: 4236136
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236136

UnificationXref4208
type: UnificationXref
id: REACT_87494
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87494.9

UnificationXref4207
type: UnificationXref
id: 4234275
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234275

UnificationXref700
type: UnificationXref
id: GO:0005769
db: GENE ONTOLOGY

UnificationXref701
type: UnificationXref
id: CHEBI:15756
db: ChEBI

UnificationXref702
type: UnificationXref
id: 76168
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76168

UnificationXref703
type: UnificationXref
id: REACT_3374
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3374.3

UnificationXref3300
type: UnificationXref
id: REACT_7505
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7505.2

UnificationXref3301
type: UnificationXref
id: 174971
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174971

UnificationXref3302
type: UnificationXref
id: REACT_7193
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7193.1

UnificationXref3303
type: UnificationXref
id: CHEBI:32643
db: ChEBI

UnificationXref3304
type: UnificationXref
id: 158676
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158676

UnificationXref3305
type: UnificationXref
id: REACT_7479
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7479.3

UnificationXref3306
type: UnificationXref
id: CHEBI:7207
db: ChEBI

UnificationXref3307
type: UnificationXref
id: 159318
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159318

UnificationXref3308
type: UnificationXref
id: REACT_7849
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7849.2

UnificationXref3309
type: UnificationXref
id: 174958
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174958

http://identifiers.org/pubmed/15956068
type: PublicationXref
id: 15956068
author: Danpure, CJ
db: Pubmed
title: Primary hyperoxaluria: from gene defects to designer drugs?
source: Nephrol Dial Transplant 20:1525-9
year: 2005

2'-deoxyadenosine 5'-diphosphate
type: SmallMoleculeReference
name: 2'-deoxyadenosine 5'-diphosphate [ChEBI:16174]
name: dADP
xref: UnificationXref2221

UnificationXref3379
type: UnificationXref
id: REACT_87382
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87382.9

UnificationXref3378
type: UnificationXref
id: 4236186
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236186

UnificationXref3377
type: UnificationXref
id: REACT_136523
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136523.5

UnificationXref3376
type: UnificationXref
id: 4236323
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236323

UnificationXref3375
type: UnificationXref
id: REACT_136481
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136481.5

UnificationXref3374
type: UnificationXref
id: 4236322
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236322

UnificationXref723
type: UnificationXref
id: CHEBI:15978
db: ChEBI

UnificationXref3372
type: UnificationXref
id: 4235439
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235439

UnificationXref722
type: UnificationXref
id: REACT_77990
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77990.9

UnificationXref3373
type: UnificationXref
id: REACT_142823
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142823.5

UnificationXref725
type: UnificationXref
id: REACT_4327
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4327.2

UnificationXref3370
type: UnificationXref
id: 1247913
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1247913

UnificationXref724
type: UnificationXref
id: 76114
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76114

UnificationXref3371
type: UnificationXref
id: REACT_76051
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_76051.1

UnificationXref721
type: UnificationXref
id: 4236109
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236109

UnificationXref720
type: UnificationXref
id: REACT_113523
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113523.8

UnificationXref727
type: UnificationXref
id: 4234167
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234167

UnificationXref726
type: UnificationXref
id: O69664
db: UniProt

UnificationXref729
type: UnificationXref
id: REACT_148939
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148939.4

UnificationXref728
type: UnificationXref
id: 4234169
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234169

UnificationXref3368
type: UnificationXref
id: 400144
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=400144

UnificationXref3367
type: UnificationXref
id: REACT_2965
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2965.2

UnificationXref3369
type: UnificationXref
id: REACT_20059
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20059.1

UnificationXref3364
type: UnificationXref
id: REACT_3188
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3188.2

UnificationXref3363
type: UnificationXref
id: 29500
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29500

UnificationXref3366
type: UnificationXref
id: 29702
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29702

UnificationXref3365
type: UnificationXref
id: CHEBI:16414
db: ChEBI

UnificationXref714
type: UnificationXref
id: O06172
db: UniProt

UnificationXref713
type: UnificationXref
id: 4235215
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235215

UnificationXref3360
type: UnificationXref
id: 351990
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=351990

UnificationXref712
type: UnificationXref
id: Q10782
db: UniProt

UnificationXref3361
type: UnificationXref
id: REACT_14295
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14295.2

UnificationXref711
type: UnificationXref
id: REACT_22804
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22804.1

UnificationXref3362
type: UnificationXref
id: CHEBI:16828
db: ChEBI

UnificationXref710
type: UnificationXref
id: 548836
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=548836

UnificationXref719
type: UnificationXref
id: 4236302
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236302

UnificationXref718
type: UnificationXref
id: REACT_132910
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132910.5

UnificationXref717
type: UnificationXref
id: 4235219
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235219

UnificationXref716
type: UnificationXref
id: 4235217
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235217

UnificationXref715
type: UnificationXref
id: 4235216
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235216

(9Z)-octadec-9-enoic acid
type: SmallMoleculeReference
name: Oleic acid
name: ChEBI:16196 Oleic acid
xref: UnificationXref4479

UnificationXref3355
type: UnificationXref
id: REACT_14674
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14674.2

UnificationXref3354
type: UnificationXref
id: 351979
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=351979

UnificationXref3353
type: UnificationXref
id: CHEBI:18019
db: ChEBI

http://identifiers.org/pubmed/5441548
type: PublicationXref
id: 5441548
author: Salen, G
author: Grundy, SM
author: Ahrens EH, Jr
db: Pubmed
title: Metabolism of beta-sitosterol in man
source: J Clin Invest 49:952-67
year: 1970

UnificationXref3352
type: UnificationXref
id: REACT_3962
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3962.2

UnificationXref3359
type: UnificationXref
id: CHEBI:16857
db: ChEBI

UnificationXref3358
type: UnificationXref
id: REACT_2613
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2613.2

http://identifiers.org/pubmed/17011499
type: PublicationXref
id: 17011499
author: Farmer, SR
db: Pubmed
title: Transcriptional control of adipocyte formation
source: Cell Metab 4:263-73
year: 2006

UnificationXref3357
type: UnificationXref
id: 113538
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113538

UnificationXref750
type: UnificationXref
id: CHEBI:16337
db: ChEBI

UnificationXref3356
type: UnificationXref
id: CHEBI:17203
db: ChEBI

UnificationXref741
type: UnificationXref
id: 4234162
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234162

UnificationXref740
type: UnificationXref
id: 4234161
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234161

UnificationXref743
type: UnificationXref
id: REACT_113073
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113073.8

UnificationXref742
type: UnificationXref
id: 4234164
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234164

UnificationXref745
type: UnificationXref
id: 1500604
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500604

UnificationXref3350
type: UnificationXref
id: CHEBI:15603
db: ChEBI

UnificationXref744
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

UnificationXref3351
type: UnificationXref
id: 29588
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29588

UnificationXref747
type: UnificationXref
id: CHEBI:17984
db: ChEBI

UnificationXref746
type: UnificationXref
id: REACT_119202
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119202.1

UnificationXref749
type: UnificationXref
id: REACT_118995
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118995.1

UnificationXref748
type: UnificationXref
id: 1500578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500578

UnificationXref3349
type: UnificationXref
id: REACT_3974
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3974.2

UnificationXref3342
type: UnificationXref
id: 29432
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29432

UnificationXref3341
type: UnificationXref
id: CHEBI:16977
db: ChEBI

UnificationXref3344
type: UnificationXref
id: CHEBI:15971
db: ChEBI

UnificationXref3343
type: UnificationXref
id: REACT_3437
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3437.2

Sulfate [ChEBI:16189]
type: SmallMoleculeReference
name: Sulfuric acid
name: Sulfate
xref: UnificationXref461

UnificationXref3346
type: UnificationXref
id: REACT_3169
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3169.2

UnificationXref3345
type: UnificationXref
id: 29612
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29612

UnificationXref3348
type: UnificationXref
id: 30102
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30102

UnificationXref3347
type: UnificationXref
id: CHEBI:17191
db: ChEBI

UnificationXref732
type: UnificationXref
id: REACT_5036
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5036.4

UnificationXref731
type: UnificationXref
id: 75967
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=75967

UnificationXref730
type: UnificationXref
id: CHEBI:37554
db: ChEBI

http://identifiers.org/pubmed/12124775
type: PublicationXref
id: 12124775
author: Nugent, Matthew A
author: Chu, Chia L
author: Buczek-Thomas, Jo Ann
author: Stone, Phillip J
author: Rich, Celeste B
author: Foster, Judith A
db: Pubmed
title: Heparan sulfate depletion within pulmonary fibroblasts: implications for elastogenesis and repair
source: J. Cell. Physiol. 192:294-303
year: 2002

UnificationXref736
type: UnificationXref
id: O53207
db: UniProt

UnificationXref735
type: UnificationXref
id: REACT_4701
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4701.3

UnificationXref734
type: UnificationXref
id: 76112
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76112

UnificationXref733
type: UnificationXref
id: CHEBI:16975
db: ChEBI

UnificationXref3340
type: UnificationXref
id: REACT_76393
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_76393.1

http://identifiers.org/pubmed/15167709
type: PublicationXref
id: 15167709
author: Blanchard, RL
author: Buck, J
author: Freimuth, RR
author: Coughtrie, MW
author: Weinshilboum, RM
db: Pubmed
title: A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily
source: Pharmacogenetics 14:199-211
year: 2004

http://identifiers.org/pubmed/15257288
type: PublicationXref
id: 15257288
author: Lauer-Fields, JL
author: Chung, L
author: Visse, R
author: Fields, GB
author: Yoshida, N
author: Dinakarpandian, D
author: Nagase, H
db: Pubmed
title: Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis
source: EMBO J 23:3020-30
year: 2004

UnificationXref739
type: UnificationXref
id: 4234160
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234160

UnificationXref738
type: UnificationXref
id: P65734
db: UniProt

UnificationXref737
type: UnificationXref
id: 4234159
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234159

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P63719
data source: Provenance1
name: CP26_HUMAN
name: CYP26A1
name: Cytochrome P450 26
xref: UnificationXref3153
feature: FragmentFeature267
cellular location: GO:0005622
comment: Reactome DB_ID: 4234830
display name: P63719

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P63715
data source: Provenance1
name: CP26_HUMAN
name: CYP26A1
name: Cytochrome P450 26
xref: UnificationXref3155
feature: FragmentFeature268
cellular location: GO:0005622
comment: Reactome DB_ID: 4234831
display name: P63715

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P95099
data source: Provenance1
name: CP26_HUMAN
name: CYP26A1
name: Cytochrome P450 26
xref: UnificationXref3157
feature: FragmentFeature269
cellular location: GO:0005622
comment: Reactome DB_ID: 4234832
display name: P95099

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O08447
data source: Provenance1
name: CP26_HUMAN
name: CYP26A1
name: Cytochrome P450 26
xref: UnificationXref3159
feature: FragmentFeature270
cellular location: GO:0005622
comment: Reactome DB_ID: 4234833
display name: O08447

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O69653
data source: Provenance1
name: CP26_HUMAN
name: CYP26A1
name: Cytochrome P450 26
xref: UnificationXref3161
feature: FragmentFeature271
cellular location: GO:0005622
comment: Reactome DB_ID: 4234834
display name: O69653

UnificationXref2283
type: UnificationXref
id: 4234376
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234376

UnificationXref2284
type: UnificationXref
id: REACT_155156
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155156.3

UnificationXref2281
type: UnificationXref
id: 4234374
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234374

UnificationXref2282
type: UnificationXref
id: REACT_159228
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159228.3

UnificationXref2280
type: UnificationXref
id: 4234372
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234372

UnificationXref2289
type: UnificationXref
id: REACT_2972
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2972.2

UnificationXref2288
type: UnificationXref
id: 110095
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110095

UnificationXref2287
type: UnificationXref
id: CHEBI:18075
db: ChEBI

UnificationXref2286
type: UnificationXref
id: REACT_154304
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154304.3

UnificationXref2285
type: UnificationXref
id: 4234375
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234375

Protoporphyrinogen oxidase
type: Protein
entity reference: P0A5A7
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P0A5A7
name: PPOX_HUMAN
xref: UnificationXref3096
feature: FragmentFeature263
cellular location: GO:0005622
comment: Reactome DB_ID: 4234530
display name: PPOX

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53231
data source: Provenance1
name: O53231
name: DCUP_HUMAN
name: Uroporphyrinogen III decarboxylase
xref: UnificationXref3072
feature: FragmentFeature262
cellular location: GO:0005622
comment: Reactome DB_ID: 4234536
display name: UROD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O06809
data source: Provenance1
name: Protoheme IX farnesyltransferase, mitochondrial ecNumber2.5.1.-/ecNumber
name: COX10(?-443)
name: COX10_HUMAN
name: O06809
xref: UnificationXref3121
feature: FragmentFeature265
cellular location: GO:0005622
comment: Reactome DB_ID: 4236031
display name: COX10

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A576
data source: Provenance1
name: Ferrochelatase
name: P0A576
name: HEMZ_HUMAN
xref: UnificationXref3109
feature: FragmentFeature264
cellular location: GO:0005622
comment: Reactome DB_ID: 4234548
display name: FECH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P63717
data source: Provenance1
name: CP26_HUMAN
name: CYP26A1
name: Cytochrome P450 26
xref: UnificationXref3151
feature: FragmentFeature266
cellular location: GO:0005622
comment: Reactome DB_ID: 4234829
display name: P63717

Homologues of CYP26A1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3162
cellular location: GO:0005622
comment: Reactome DB_ID: 4234835
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P95099
data source: Provenance1
name: Cytochrome P450 26B1
name: CYP26B1
name: C26A_HUMAN
xref: UnificationXref3170
feature: FragmentFeature276
cellular location: GO:0005622
comment: Reactome DB_ID: 4234824
display name: P95099

http://identifiers.org/pubmed/16498449
type: PublicationXref
id: 16498449
author: Hoffman, HM
author: Kastner, DL
author: Ting, JP
db: Pubmed
title: CATERPILLERs, pyrin and hereditary immunological disorders
source: Nat Rev Immunol 6:183-95
year: 2006

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O08447
data source: Provenance1
name: Cytochrome P450 26B1
name: CYP26B1
name: C26A_HUMAN
xref: UnificationXref3171
feature: FragmentFeature277
cellular location: GO:0005622
comment: Reactome DB_ID: 4234825
display name: O08447

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P63717
data source: Provenance1
name: CP26C_HUMAN
name: CYP26C1
name: Cytochrome P450 26C1
xref: UnificationXref3182
feature: FragmentFeature279
cellular location: GO:0005622
comment: Reactome DB_ID: 4234803
display name: P63717

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P63719
data source: Provenance1
name: CP26C_HUMAN
name: CYP26C1
name: Cytochrome P450 26C1
xref: UnificationXref3183
feature: FragmentFeature280
cellular location: GO:0005622
comment: Reactome DB_ID: 4234806
display name: P63719

Homologues of CYP26C1
type: Protein
data source: Provenance1
member physical entity: Protein338
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Protein337
member physical entity: Protein336
xref: UnificationXref3187
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234816

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O69653
data source: Provenance1
name: CP26C_HUMAN
name: CYP26C1
name: Cytochrome P450 26C1
xref: UnificationXref3181
feature: FragmentFeature278
cellular location: GO:0005622
comment: Reactome DB_ID: 4234800
display name: O69653

UnificationXref2270
type: UnificationXref
id: REACT_21608
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21608.1

UnificationXref2271
type: UnificationXref
id: 4234363
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234363

UnificationXref2272
type: UnificationXref
id: 4234366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234366

UnificationXref2273
type: UnificationXref
id: 4234367
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234367

UnificationXref2279
type: UnificationXref
id: 4234371
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234371

UnificationXref2278
type: UnificationXref
id: 4234370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234370

UnificationXref2275
type: UnificationXref
id: REACT_4986
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4986.2

UnificationXref2274
type: UnificationXref
id: 111793
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111793

UnificationXref2277
type: UnificationXref
id: 4234369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234369

UnificationXref2276
type: UnificationXref
id: 4234368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234368

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P63719
data source: Provenance1
name: Cytochrome P450 26B1
name: CYP26B1
name: C26A_HUMAN
xref: UnificationXref3168
feature: FragmentFeature274
cellular location: GO:0005622
comment: Reactome DB_ID: 4234822
display name: P63719

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P63717
data source: Provenance1
name: Cytochrome P450 26B1
name: CYP26B1
name: C26A_HUMAN
xref: UnificationXref3167
feature: FragmentFeature273
cellular location: GO:0005622
comment: Reactome DB_ID: 4234821
display name: P63717

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O69653
data source: Provenance1
name: Cytochrome P450 26B1
name: CYP26B1
name: C26A_HUMAN
xref: UnificationXref3166
feature: FragmentFeature272
cellular location: GO:0005622
comment: Reactome DB_ID: 4234820
display name: O69653

Homologues of CYP26B1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3172
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234826

http://identifiers.org/pubmed/8068008
type: PublicationXref
id: 8068008
author: Rödl, W
author: Rücknagel, KP
author: Werner, T
author: Bacher, A
author: Jaeger, E
author: Ziegler, I
author: Gütlich, M
db: Pubmed
title: Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme
source: Biochem J 302:215-21
year: 1994

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P63715
data source: Provenance1
name: Cytochrome P450 26B1
name: CYP26B1
name: C26A_HUMAN
xref: UnificationXref3169
feature: FragmentFeature275
cellular location: GO:0005622
comment: Reactome DB_ID: 4234823
display name: P63715

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53764
data source: Provenance1
name: ASMT_HUMAN
name: Hydroxyindole O-methyltransferase
name: O53764
name: Acetylserotonin O-methyltransferase ecNumber2.1.1.4/ecNumber
xref: UnificationXref2905
feature: FragmentFeature249
cellular location: GO:0005622
comment: Reactome DB_ID: 4234795
display name: ASMT

O07727
type: Protein
entity reference: O07727
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: D-amino-acid oxidase
xref: UnificationXref2924
feature: FragmentFeature250
cellular location: GO:0005622
comment: Reactome DB_ID: 4235003
display name: DAO

http://identifiers.org/pubmed/10801319
type: PublicationXref
id: 10801319
author: Holden, HM
author: Thoden, JB
author: Wohlers, TM
author: Fridovich-Keil, JL
db: Pubmed
title: Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase
source: Biochemistry 39:5691-701
year: 2000

Homologues of HAO1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P95040
xref: UnificationXref2938
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4235014

http://identifiers.org/pubmed/8943353
type: PublicationXref
id: 8943353
author: Nevins, JR
author: Herendeen, DR
author: DeGregori, J
author: Leone, G
author: Ohtani, K
author: Kelly, TJ
db: Pubmed
title: Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor
source: Mol Cell Biol 16:6977-84
year: 1996

UnificationXref2261
type: UnificationXref
id: 111783
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111783

UnificationXref2262
type: UnificationXref
id: REACT_4262
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4262.2

UnificationXref2260
type: UnificationXref
id: REACT_21992
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21992.1

UnificationXref2266
type: UnificationXref
id: REACT_4892
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4892.2

UnificationXref2265
type: UnificationXref
id: 111784
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111784

UnificationXref2264
type: UnificationXref
id: REACT_5414
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5414.2

UnificationXref2263
type: UnificationXref
id: 111785
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111785

UnificationXref2269
type: UnificationXref
id: 499939
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=499939

UnificationXref2268
type: UnificationXref
id: REACT_5731
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5731.2

UnificationXref2267
type: UnificationXref
id: 111786
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111786

http://identifiers.org/pubmed/18048764
type: PublicationXref
id: 18048764
author: Eizirik, DL
author: Cnop, M
author: Cardozo, AK
db: Pubmed
title: The role for endoplasmic reticulum stress in diabetes mellitus
source: Endocr Rev 29:42-61
year: 2008

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O33357
data source: Provenance1
name: O33357
name: HEM2_HUMAN
name: Delta-aminolevulinic acid dehydratase
xref: UnificationXref3038
feature: FragmentFeature260
cellular location: GO:0005622
comment: Reactome DB_ID: 4234542
display name: ALAD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P64336
data source: Provenance1
name: HEM3_HUMAN
name: Porphobilinogen deaminase
name: P64336
xref: UnificationXref3058
feature: FragmentFeature261
cellular location: GO:0005622
comment: Reactome DB_ID: 4234524
display name: HMBS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O07255
data source: Provenance1
name: 2xHC-SQRDL(1-450)
name: SQR(ox.)
xref: UnificationXref3021
feature: ModificationFeature49
feature: ModificationFeature48
feature: FragmentFeature258
cellular location: GO:0005622
comment: Reactome DB_ID: 4235593
display name: O07255

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O07255
data source: Provenance1
name: CysS-SQRDL(1-450)
name: SQR-S-SH
xref: UnificationXref3023
feature: FragmentFeature259
feature: ModificationFeature50
cellular location: GO:0005622
comment: Reactome DB_ID: 4235586
display name: O07255

http://identifiers.org/pubmed/16543958
type: PublicationXref
id: 16543958
author: Hirsch, E
author: Rommel, C
author: Barberis, L
author: Montrucchio, G
author: Lembo, G
author: Costa, C
db: Pubmed
title: Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing
source: Thromb Haemost 95:29-35
year: 2006

UnificationXref2250
type: UnificationXref
id: 4234360
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234360

UnificationXref2251
type: UnificationXref
id: 113582
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113582

UnificationXref2253
type: UnificationXref
id: 111349
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111349

UnificationXref2252
type: UnificationXref
id: REACT_3850
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3850.1

UnificationXref2255
type: UnificationXref
id: 111809
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111809

UnificationXref2254
type: UnificationXref
id: REACT_4307
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4307.1

UnificationXref2257
type: UnificationXref
id: 111814
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111814

UnificationXref2256
type: UnificationXref
id: REACT_3101
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3101.2

UnificationXref2259
type: UnificationXref
id: 499944
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=499944

UnificationXref2258
type: UnificationXref
id: REACT_5432
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5432.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53227
data source: Provenance1
name: CNDP2_HUMAN
name: O53227
name: Cytosolic non-specific dipeptidase
xref: UnificationXref2995
feature: FragmentFeature257
cellular location: GO:0005622
comment: Reactome DB_ID: 4235430
display name: CNDP2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Rv1079
data source: Provenance1
name: Cystathionine gamma-lyase
name: P66875
xref: UnificationXref2985
feature: FragmentFeature256
cellular location: GO:0005622
comment: Reactome DB_ID: 4235573
display name: CTH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7D8W0
data source: Provenance1
name: Q7D8W0
name: PXLP-CBS(2-550)
name: Cystathionine beta-synthase
xref: UnificationXref2974
feature: FragmentFeature255
feature: ModificationFeature47
cellular location: GO:0005622
comment: Reactome DB_ID: 4235568
display name: CBS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P96871
data source: Provenance1
name: P96871
name: MAT2B isoform-1
xref: UnificationXref2958
feature: FragmentFeature254
cellular location: GO:0005622
comment: Reactome DB_ID: 4234500
display name: MAT2B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P77899
data source: Provenance1
name: MAT I/III
name: P77899
xref: UnificationXref2954
feature: FragmentFeature253
cellular location: GO:0005622
comment: Reactome DB_ID: 4234494
display name: MAT1A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P95143
data source: Provenance1
name: HAOX1
name: Hydroxyacid oxidase 1
name: P95143
xref: UnificationXref2937
feature: FragmentFeature252
cellular location: GO:0005622
comment: Reactome DB_ID: 4235013
display name: HAO1

P95040
type: Protein
entity reference: P95040
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: HAOX1
name: Hydroxyacid oxidase 1
xref: UnificationXref2935
feature: FragmentFeature251
cellular location: GO:0005622
comment: Reactome DB_ID: 4235010
display name: HAO1

UnificationXref2240
type: UnificationXref
id: 4234346
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234346

http://identifiers.org/pubmed/20023662
type: PublicationXref
id: 20023662
author: Choi, I
author: Thorens, B
author: Zhou, R
author: Tschopp, J
author: Tardivel, A
db: Pubmed
title: Thioredoxin-interacting protein links oxidative stress to inflammasome activation
source: Nat Immunol 11:136-40
year: 2010

UnificationXref2249
type: UnificationXref
id: 4234359
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234359

UnificationXref2247
type: UnificationXref
id: 4234358
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234358

UnificationXref2248
type: UnificationXref
id: REACT_159655
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159655.3

UnificationXref2245
type: UnificationXref
id: 4234355
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234355

UnificationXref2246
type: UnificationXref
id: 4234356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234356

UnificationXref2243
type: UnificationXref
id: 111736
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111736

UnificationXref2244
type: UnificationXref
id: REACT_5725
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5725.2

UnificationXref2241
type: UnificationXref
id: 4234347
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234347

UnificationXref2242
type: UnificationXref
id: CHEBI:29034
db: ChEBI

http://identifiers.org/pubmed/9706223
type: PublicationXref
id: 9706223
author: Kerner, J
author: Hoppel, C
db: Pubmed
title: Genetic disorders of carnitine metabolism and their nutritional management.
source: Annu Rev Nutr 18:179-206
year: 1998

http://identifiers.org/pubmed/17644602
type: PublicationXref
id: 17644602
author: Hsu, T
author: Jacobs WR, Jr
author: Leyh, TS
author: Harrison, JS
author: Pinto, R
db: Pubmed
title: Sulfite reduction in mycobacteria
source: J Bacteriol 189:6714-22
year: 2007

UnificationXref2238
type: UnificationXref
id: 4233929
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233929

UnificationXref2239
type: UnificationXref
id: P0A5W8
db: UniProt

UnificationXref2234
type: UnificationXref
id: REACT_21937
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21937.1

UnificationXref2235
type: UnificationXref
id: MOD:00798
db: MOD

UnificationXref2236
type: UnificationXref
id: 4233923
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233923

UnificationXref2237
type: UnificationXref
id: 4233928
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233928

UnificationXref2230
type: UnificationXref
id: CHEBI:28850
db: ChEBI

http://identifiers.org/pubmed/16476485
type: PublicationXref
id: 16476485
author: Wahli, W
author: Gelman, L
author: Feige, JN
author: Desvergne, B
author: Michalik, L
db: Pubmed
title: From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
source: Prog Lipid Res 45:120-59
year: 2006

UnificationXref2231
type: UnificationXref
id: 110093
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110093

UnificationXref2232
type: UnificationXref
id: REACT_5210
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5210.2

Sulfide oxidation to sulfate
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction267
evidence: Evidence429
xref: UnificationXref3030
xref: UnificationXref3029
xref: RelationshipXref453
pathway order: PathwayStep426
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2233
type: UnificationXref
id: 499933
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=499933

Shikimate
type: SmallMoleculeReference
name: Shikimic acid
name: Shikimate [ChEBI:9133]
name: 3,4,5-Trihydroxy-1-cyclohexenecarboxylic acid
xref: UnificationXref5339

UnificationXref2229
type: UnificationXref
id: REACT_4046
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4046.2

UnificationXref2227
type: UnificationXref
id: CHEBI:28846
db: ChEBI

UnificationXref2228
type: UnificationXref
id: 110091
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110091

UnificationXref2221
type: UnificationXref
id: CHEBI:16174
db: ChEBI

UnificationXref2222
type: UnificationXref
id: 110090
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110090

UnificationXref2220
type: UnificationXref
id: REACT_22084
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22084.1

UnificationXref2225
type: UnificationXref
id: 110092
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110092

cholest-5-en-3beta-ol
type: SmallMoleculeReference
name: cholesterol
name: cholesterol [ChEBI:16113]
xref: UnificationXref544

UnificationXref2226
type: UnificationXref
id: REACT_4501
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4501.2

UnificationXref2223
type: UnificationXref
id: REACT_4457
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4457.2

UnificationXref2224
type: UnificationXref
id: CHEBI:28862
db: ChEBI

Dihydroxyacetone phosphate
type: SmallMoleculeReference
name: Glycerone phosphate
name: Dihydroxyacetone phosphate [ChEBI:16108]
xref: UnificationXref201

http://identifiers.org/pubmed/1748670
type: PublicationXref
id: 1748670
author: Gozes, Y
author: Grosfeld, H
author: Velan, B
author: Leitner, M
author: Lazar, A
author: Kronman, C
author: Marcus, D
author: Flashner, Y
author: Shafferman, A
author: Cohen, S
db: Pubmed
title: The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant
source: J Biol Chem 266:23977-84
year: 1991

UnificationXref2216
type: UnificationXref
id: REACT_2815
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2815.2

UnificationXref2217
type: UnificationXref
id: 110096
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110096

UnificationXref2218
type: UnificationXref
id: REACT_2602
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2602.2

UnificationXref2219
type: UnificationXref
id: 499930
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=499930

UnificationXref2210
type: UnificationXref
id: 4233930
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233930

UnificationXref2211
type: UnificationXref
id: O53161
db: UniProt

UnificationXref2212
type: UnificationXref
id: 4233931
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233931

UnificationXref2213
type: UnificationXref
id: 4233932
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233932

UnificationXref2214
type: UnificationXref
id: CHEBI:17239
db: ChEBI

UnificationXref2215
type: UnificationXref
id: 110094
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110094

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O33185
data source: Provenance1
name: S27A5_HUMAN
name: VLCS-H2
name: Bile acyl-CoA synthetase
name: O33185
name: SLC27A5
xref: UnificationXref1315
feature: FragmentFeature126
cellular location: GO:0005622
comment: Reactome DB_ID: 4234454
display name: BACS

http://identifiers.org/pubmed/17804665
type: PublicationXref
id: 17804665
author: Miethke, M
author: Marahiel, MA
db: Pubmed
title: Siderophore-based iron acquisition and pathogen control
source: Microbiol Mol Biol Rev 71:413-51
year: 2007

http://identifiers.org/pubmed/17475546
type: PublicationXref
id: 17475546
author: Heikkinen, S
author: Argmann, CA
author: Auwerx, J
db: Pubmed
title: PPARgamma in human and mouse physiology
source: Biochim Biophys Acta 1771:999-1013
year: 2007

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P72007
data source: Provenance1
name: S27A5_HUMAN
name: VLCS-H2
name: Bile acyl-CoA synthetase
name: P72007
name: SLC27A5
xref: UnificationXref1316
feature: FragmentFeature127
cellular location: GO:0005622
comment: Reactome DB_ID: 4234457
display name: BACS

O05307
type: Protein
entity reference: O05307
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: S27A5_HUMAN
name: VLCS-H2
name: Bile acyl-CoA synthetase
name: SLC27A5
xref: UnificationXref1317
feature: FragmentFeature128
cellular location: GO:0005622
comment: Reactome DB_ID: 4234460
display name: BACS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53551
data source: Provenance1
name: S27A5_HUMAN
name: O53551
name: VLCS-H2
name: Bile acyl-CoA synthetase
name: SLC27A5
xref: UnificationXref1318
feature: FragmentFeature129
cellular location: GO:0005622
comment: Reactome DB_ID: 4234463
display name: BACS

Homologues of ABCB11
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1372
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234621

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P63393
data source: Provenance1
name: P63393
name: ATP-binding cassette sub-family B member 11
name: Bile salt export pump
xref: UnificationXref1370
feature: FragmentFeature130
cellular location: GO:0005886
comment: Reactome DB_ID: 4234617
display name: ABCB11

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A4W4
data source: Provenance1
name: P0A4W4
name: ATP-binding cassette sub-family B member 11
name: Bile salt export pump
xref: UnificationXref1371
feature: FragmentFeature131
cellular location: GO:0005886
comment: Reactome DB_ID: 4234620
display name: ABCB11

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A512
data source: Provenance1
name: CYP39A1
name: C39A_HUMAN
name: Cytochrome P450 39A1
xref: UnificationXref1383
feature: FragmentFeature132
cellular location: GO:0005622
comment: Reactome DB_ID: 4234585
display name: P0A512

Cytochrome P450 (CYP7B1 based)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1436
cellular location: GO:0005622
comment: Reactome DB_ID: 4234563
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A512
data source: Provenance1
name: P0A512
name: Cytochrome P450 7B1
name: CP7B_HUMAN
xref: UnificationXref1435
feature: FragmentFeature133
cellular location: GO:0005622
comment: Reactome DB_ID: 4234562
display name: CYP7B1

Homologues of HSD17B3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1484
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234613

O53207
type: Protein
entity reference: O53207
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Acyl- CoA:dihydroxyacetonephosphateacyltransferase
name: Glycerone-phosphate O-acyltransferase
name: DHAP-AT
name: DAP-AT
name: Dihydroxyacetone phosphate acyltransferase
xref: UnificationXref1198
feature: FragmentFeature119
cellular location: GO:0005622
comment: Reactome DB_ID: 4234136
display name: GNPAT

Homologues of GNPAT
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: O53207
xref: UnificationXref1200
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234140

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P65734
data source: Provenance1
name: Acyl- CoA:dihydroxyacetonephosphateacyltransferase
name: Glycerone-phosphate O-acyltransferase
name: P65734
name: DHAP-AT
name: DAP-AT
name: Dihydroxyacetone phosphate acyltransferase
xref: UnificationXref1199
feature: FragmentFeature120
cellular location: GO:0005622
comment: Reactome DB_ID: 4234139
display name: GNPAT

lanosterol 14alpha-demethylase
type: Protein
entity reference: P0A512
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: CYP51A1
xref: UnificationXref1267
feature: FragmentFeature123
cellular location: GO:0005622
comment: Reactome DB_ID: 4234652
display name: P0A512

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O69686
data source: Provenance1
name: O69686
xref: UnificationXref1276
feature: FragmentFeature124
cellular location: GO:0005622
comment: Reactome DB_ID: 4234657
display name: DHCR24

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P65097
data source: Provenance1
name: P65097
name: Isocitrate dehydrogenase (NADP) cytoplasmic
name: PICD
xref: UnificationXref1231
feature: FragmentFeature121
cellular location: GO:0005622
comment: Reactome DB_ID: 4234985
display name: IDH1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P72002
data source: Provenance1
name: IDI1_HUMAN
name: Isopentenyl-diphosphate delta-isomerase 1
name: P72002
xref: UnificationXref1251
feature: FragmentFeature122
cellular location: GO:0005622
comment: Reactome DB_ID: 4234558
display name: IDI1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A512
data source: Provenance1
name: P0A512
name: CYP8B1(1-501)
name: CP8B_HUMAN
name: Cytochrome P450 8B1
xref: UnificationXref1293
feature: FragmentFeature125
cellular location: GO:0005622
comment: Reactome DB_ID: 4234581
display name: CYP8B1

Same Catalyst Activity
type: RelationshipTypeVocabulary

Homologues of SLC27A5
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: O05307
xref: UnificationXref1319
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234464

Cytochrome P450 (CYP7A1 based)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1284
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234567

Cytochrome P450 (CYP8B1 based)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1294
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234582

PublicationXref113
type: PublicationXref
author: Tyfield, LA
author: Walter, JH
author: Holton, JB
title: Galactosemia
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Scriver CR, et al., editors) 1:1553-1587
year: 2001

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O06138
data source: Provenance1
name: Multidrug resistance-associated protein 1
name: O06138
xref: UnificationXref1612
feature: FragmentFeature141
cellular location: GO:0005886
comment: Reactome DB_ID: 4234848
display name: ABCC1

Homologues of EPHX2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1649
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4235810

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O06266
data source: Provenance1
name: Epoxide hydrolase 2
name: HYES_HUMAN
name: O06266
xref: UnificationXref1646
feature: FragmentFeature142
cellular location: GO:0005622
comment: Reactome DB_ID: 4235806
display name: EPHX2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P95276
data source: Provenance1
name: Epoxide hydrolase 2
name: P95276
name: HYES_HUMAN
xref: UnificationXref1648
feature: FragmentFeature143
cellular location: GO:0005622
comment: Reactome DB_ID: 4235809
display name: EPHX2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O05572
data source: Provenance1
name: Decaprenyl-diphosphate synthase subunit 2 ecNumber2.5.1.91/ecNumber
name: O05572
name: DLP1_HUMAN
xref: UnificationXref1710
feature: FragmentFeature147
cellular location: GO:0005622
comment: Reactome DB_ID: 4235830
display name: PDSS2

Homologues of PDSS1
type: Protein
data source: Provenance1
member physical entity: O06428
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1716
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4235827

http://identifiers.org/pubmed/16969069
type: PublicationXref
id: 16969069
author: Tang, CK
author: Yu, H
author: Han, W
author: Foulke, JG
author: Zhang, T
db: Pubmed
title: Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII
source: Cancer Biol Ther 5:1361-8
year: 2006

http://identifiers.org/pubmed/15703182
type: PublicationXref
id: 15703182
author: Mischenko, VV
author: McAlister, MS
author: Harris, R
author: Driscoll, PC
author: Murphy, HN
author: Robertson, BD
author: Stewart, GR
author: Young, DB
author: Apt, AS
db: Pubmed
title: The OtsAB pathway is essential for trehalose biosynthesis in Mycobacterium tuberculosis
source: J Biol Chem 280:14524-9
year: 2005

O06249
type: Protein
entity reference: O06249
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PXLP-SGPL1
name: sphingosine-1-phosphate lyase 1
xref: UnificationXref1667
feature: FragmentFeature144
feature: ModificationFeature27
cellular location: GO:0005622
comment: Reactome DB_ID: 4235114
display name: SGPL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O06769
data source: Provenance1
name: ASAH2(1-780)
name: Neutral ceramidase
name: ASAH2_HUMAN
name: O06769
xref: UnificationXref1690
feature: FragmentFeature145
cellular location: GO:0005886
comment: Reactome DB_ID: 4235556
display name: ASAH2

Homologues of PDSS2
type: Protein
data source: Provenance1
member physical entity: O06428
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1711
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4235831

O06428
type: Protein
entity reference: O06428
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Decaprenyl-diphosphate synthase subunit 2 ecNumber2.5.1.91/ecNumber
name: DLP1_HUMAN
xref: UnificationXref1708
feature: FragmentFeature146
cellular location: GO:0005622
comment: Reactome DB_ID: 4235829
display name: PDSS2

UniProt:P02788 LTF
type: ProteinReference
name: LTF
name: LF
xref: UnificationXref4890
comment: FUNCTION Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.FUNCTION Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration.FUNCTION Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.FUNCTION The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.FUNCTION Isoform DeltaLf: transcription factor with antiproliferative properties and inducing cell cycle arrest. Binds to DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.CATALYTIC ACTIVITY Preferential at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin.SUBUNIT Monomer. Found in a complex with LTF, CLU, EPPIN and SEMG1.PTM Isoform DeltaLf: Ubiquitinated at Lys-379 and Lys-391.SIMILARITY Belongs to the transferrin family.SIMILARITY Contains 2 transferrin-like domains.
organism: BioSource2

UniProt:P65170
type: ProteinReference
xref: UnificationXref2050
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O06172
data source: Provenance1
name: Estradiol 17beta-dehydrogenase
name: HSD17B3
xref: UnificationXref1483
feature: FragmentFeature135
cellular location: GO:0005622
comment: Reactome DB_ID: 4234612
display name: O06172

Homologues of GPAT2
type: Protein
data source: Provenance1
member physical entity: glycerol-3-phosphate acyltransferase 2, mitochondrial
member physical entity: O53207
xref: UnificationXref1500
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4235529

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q10782
data source: Provenance1
name: Estradiol 17beta-dehydrogenase
name: HSD17B3
xref: UnificationXref1482
feature: FragmentFeature134
cellular location: GO:0005622
comment: Reactome DB_ID: 4234609
display name: Q10782

http://identifiers.org/pubmed/12450384
type: PublicationXref
id: 12450384
author: Zhang, Y
author: Desharnais, J
author: Beardsley, GP
author: Wilson, IA
author: Greasley, SE
author: Boger, DL
db: Pubmed
title: Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR
source: Biochemistry 41:14206-14215
year: 2002

UniProt:P65172
type: ProteinReference
xref: UnificationXref2052
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A512
data source: Provenance1
name: Prostacyclin synthase
name: P0A512
name: Cytochrome P450 8A1
name: Prostaglandin I2 synthase
xref: UnificationXref1600
feature: FragmentFeature140
cellular location: GO:0005622
comment: Reactome DB_ID: 4234172
display name: PTGIS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53452
data source: Provenance1
name: Acetylcholinesterase
name: O53452
xref: UnificationXref1526
feature: FragmentFeature139
cellular location: GO:0005886
comment: Reactome DB_ID: 4234858
display name: ACHE

Cytochrome P450 (CYP8A1 based)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1601
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234173

Homologues of ACHE
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1527
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234859

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53488
data source: Provenance1
name: O53488
name: Acetylcholinesterase
xref: UnificationXref1525
feature: FragmentFeature138
cellular location: GO:0005886
comment: Reactome DB_ID: 4234857
display name: ACHE

O53207
type: Protein
entity reference: O53207
data source: Provenance1
name: glycerol-3-phosphate acyltransferase 2, mitochondrial
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1498
feature: FragmentFeature136
cellular location: GO:0005622
comment: Reactome DB_ID: 4235527
display name: GPAT2

glycerol-3-phosphate acyltransferase 2, mitochondrial
type: Protein
entity reference: UniProt:P65734
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P65734
xref: UnificationXref1499
feature: FragmentFeature137
cellular location: GO:0005622
comment: Reactome DB_ID: 4235528
display name: GPAT2

UniProt:P96291
type: ProteinReference
xref: UnificationXref689
organism: BioSource1

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-oate
type: SmallMoleculeReference
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate [ChEBI:1698]
xref: UnificationXref1297

Pyridoxal 5'-phosphate
type: SmallMoleculeReference
name: Pyridoxal 5-phosphate
name: Pyridoxal phosphate
name: Pyridoxal phosphate [ChEBI:18405]
xref: UnificationXref2407

UnificationXref1203
type: UnificationXref
id: REACT_114425
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114425.8

Evidence419
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9175157
xref: http://identifiers.org/pubmed/12163696
comment: S-adenosylmethionine (SAM) is an essential metabolite in all cells. SAM is a precursor in the synthesis of polyamines. Methionine adenosyltransferase (MAT; EC 2.5.1.6) catalyzes the only known SAM biosynthetic reaction from methionine and ATP. In mammalian tissues, three different forms of MAT (MAT I, MAT III and MAT II) have been identified that are the product of two different genes (MAT1A and MAT2A). A third gene MAT2B has been identified and is known to be a part of MAT II heterotetramer complex.

UnificationXref1202
type: UnificationXref
id: 4234151
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234151

UnificationXref1201
type: UnificationXref
id: 4234149
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234149

UnificationXref1200
type: UnificationXref
id: 4234140
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234140

UnificationXref1207
type: UnificationXref
id: 390435
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390435

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P66926
data source: Provenance1
name: Acetyl-CoA acetyltransferase, mitochondrial
name: P66926
name: acetyl-CoA acetyltransferase
name: Acetoacetyl-CoA thiolase
name: ACAT1(35-427)
xref: UnificationXref1012
feature: FragmentFeature94
cellular location: GO:0005622
comment: Reactome DB_ID: 4233759
display name: ACAT1

Evidence415
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17088322
xref: http://identifiers.org/pubmed/16616139
comment: Peroxisomal D-amino-acid oxidase catalyzes the reaction of glycine, water, and O2 to form glyoxylate, H2O2, and NH4+. The active form of the enzyme is a homodimer and has FAD as a cofactor (Kawazoe et al. 2006; Molla et al. 2006).

UnificationXref1206
type: UnificationXref
id: REACT_18226
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18226.2

Homologues of OXCT1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1028
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234012

Evidence416
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10978532
xref: http://identifiers.org/pubmed/10777549
xref: http://identifiers.org/pubmed/18215067
xref: http://identifiers.org/pubmed/17669354
comment: Peroxisomal hydroxyacid oxidase 1 catalyzes the reaction of glycolate and O2 to form glyoxylate and H2O2. The active form of the enzyme is associated with FMN and is a tetramer (Jones et al. 2000; Murray et al. 2008; Vignaud et al. 2007; Williams et al. 2000).

UnificationXref1205
type: UnificationXref
id: 390440
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390440

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P63648
data source: Provenance1
name: Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial precursor
name: Succinyl CoA:3-oxoacid CoA-transferase
name: 3-oxoacid CoA-transferase monomer
name: P63648
xref: UnificationXref1025
feature: FragmentFeature95
cellular location: GO:0005622
comment: Reactome DB_ID: 4234008
display name: OXCT1

Evidence417
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10978532
xref: http://identifiers.org/pubmed/10777549
xref: http://identifiers.org/pubmed/18215067
xref: http://identifiers.org/pubmed/17669354
comment: Peroxisomal hydroxyacid oxidase 1 catalyzes the reaction of glyoxylate to form oxalate. The active form of the enzyme is associated with FMN and is a tetramer (Jones et al. 2000; Murray et al. 2008; Vignaud et al. 2007; Williams et al. 2000).

UnificationXref1204
type: UnificationXref
id: CHEBI:16125
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P63650
data source: Provenance1
name: P63650
name: Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial precursor
name: Succinyl CoA:3-oxoacid CoA-transferase
name: 3-oxoacid CoA-transferase monomer
xref: UnificationXref1027
feature: FragmentFeature96
cellular location: GO:0005622
comment: Reactome DB_ID: 4234011
display name: OXCT1

Evidence418
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15956068
comment: Glyoxylate is generated in the course of glycine and hydroxyproline catabolism and can be converted to oxalate. In humans, this process takes place in the liver. Defects in two enzymes of glyoxylate metabolism, alanine:glyoxylate aminotransferase (AGXT) and glycerate dehydrogenase/glyoxylate reductase (GRHPR), are associated with pathogenic overproduction of oxalate (Danpure 2005). The reactions that interconvert glycine, glycolate, and glyoxylate and convert glyoxylate to oxalate have been characterized in molecular detail in humans. A reaction sequence for the conversion of hydroxyproline to glyoxylate has been inferred from studies of partially purified extracts of rat and bovine liver but the enzymes involved in the corresponding human reactions have not been identified.

Homologues of GPD2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1046
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234519

Evidence411
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15784477
xref: http://identifiers.org/pubmed/12686127
xref: http://identifiers.org/pubmed/11564948
comment: Polyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that arginine can be metabolised according to the same pathway leading to agmatine formation. Polyamines are essential for the growth, the maintenance and the function of normal cells. The complexity of their metabolism and the fact that polyamines homeostasis is tightly regulated support the idea that polyamines are essential to cell survival. Multiple abnormalities in the control of polyamines metabolism might be implicated in several pathological processes (Moinard et al., 2005). Legend for the following figure:

Evidence412
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/7989373
comment: Hydroxyindole-O-methyltransferase (HIOMT) catalyzes the last step in the synthesis of melatonin. Melatonin is synthesized and released by the pineal gland and is thought to control circadian rhythms. HIOMT has 3 isoforms and utilizes S-adenosyl-L-methionine (SAM) as the methyl donor in the conversion of N-acetyl-5HT to melatonin.

UnificationXref1209
type: UnificationXref
id: CHEBI:17197
db: ChEBI

Evidence413
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16942634
xref: http://identifiers.org/pubmed/18155917
comment: Serotonin (5-HT) is a hormone and neurotransmitter used for regulatory purposes in animal CNS. In the human brain, serotonin is involved in many physiological functions such as sleep, pain, mood and is the precursor to melatonin, a hormone produced in the pineal gland.

http://identifiers.org/pubmed/12766759
type: PublicationXref
id: 12766759
author: Inohara, N
author: Nunez, G
db: Pubmed
title: NODs: intracellular proteins involved in inflammation and apoptosis
source: Nat Rev Immunol 3:371-82
year: 2003

UnificationXref1208
type: UnificationXref
id: REACT_17312
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17312.2

Evidence414
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10691773
xref: http://identifiers.org/pubmed/3297964
xref: http://identifiers.org/pubmed/16942634
comment: Catecholamines and thyroxine are synthesized from tyrosine, and serotonin and melatonin from tryptophan.

http://identifiers.org/pubmed/10441588
type: PublicationXref
id: 10441588
author: Li, TK
author: Chen, CC
author: Wang, MF
author: Chen, YC
author: Chang, YC
author: Yin, SJ
author: Lu, RB
db: Pubmed
title: Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.
source: Am J Hum Genet 65:795-807
year: 1999

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P64184
data source: Provenance1
name: P64184
xref: UnificationXref1045
feature: FragmentFeature98
cellular location: GO:0005622
comment: Reactome DB_ID: 4234518
display name: GPD2

Evidence410
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18625006
xref: http://identifiers.org/pubmed/19946895
comment: Methionine salvage is a sequential pathway of six reactions that create methionine from 5'-methylthioadenosine (MTA) which is a byproduct of polyamine biosynthesis in nearly all organisms. The process happens completely in the cytosol. It is important in humans for recycling of sulphur that has to be assimilated using energy. (Pirkov et al, 2008; Albers, 2009)

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P64182
data source: Provenance1
name: P64182
xref: UnificationXref1043
feature: FragmentFeature97
cellular location: GO:0005622
comment: Reactome DB_ID: 4234515
display name: GPD2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P63393
data source: Provenance1
name: P63393
name: MDR3_HUMAN
name: Multidrug resistance protein 3
xref: UnificationXref1050
feature: FragmentFeature99
cellular location: GO:0005886
comment: Reactome DB_ID: 4235639
display name: ABCB4

UniProt:P65165
type: ProteinReference
xref: UnificationXref512
organism: BioSource1

Homologues of ABCB4
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1053
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4235641

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A512
data source: Provenance1
name: CP7A_HUMAN
name: P0A512
name: Cytochrome P450 7A1
xref: UnificationXref1059
feature: FragmentFeature101
cellular location: GO:0005622
comment: Reactome DB_ID: 4234566
display name: CYP7A1

UniProt:P65167
type: ProteinReference
xref: UnificationXref1932
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A4W4
data source: Provenance1
name: MDR3_HUMAN
name: P0A4W4
name: Multidrug resistance protein 3
xref: UnificationXref1052
feature: FragmentFeature100
cellular location: GO:0005886
comment: Reactome DB_ID: 4235640
display name: ABCB4

Acetylation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction285
pathway component: BiochemicalReaction286
pathway component: BiochemicalReaction287
evidence: Evidence468
xref: UnificationXref3313
xref: UnificationXref3314
pathway order: PathwayStep463
pathway order: PathwayStep462
pathway order: PathwayStep464
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

MT2189
type: ProteinReference
name: MTCY270.37
name: Rv2131c
name: cysQ
name: UniProt:P65163 cysQ
xref: UnificationXref5183
comment: FUNCTION Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I-1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F-6-P)) and AMP in vitro, but this might has no significance in vivo. Glucose-1-phosphate (G-1-P), p-nitrophenyl phosphate (pNPP), and beta-glycerol phosphate (beta-GP) are also good substrates, compared to I-1-P. With much lower efficiency, can also hydrolyze inositol 2-phosphate (I-2-P) and glucose-6-phosphate (G-6-P) in vitro, but not fructose-6-phosphate (F-6-P) and trehalose-6-phosphate (T-6-P).CATALYTIC ACTIVITY Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.CATALYTIC ACTIVITY D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.CATALYTIC ACTIVITY Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.COFACTOR Magnesium. Mn(2+) can substitute for Mg(2+) for PAP phosphatase and IMPase activities, but is less efficient (50%-60% of the activity observed with Mg(2+)).ENZYME REGULATION PAP phosphatase and IMPase activities are inhibited by Li(+). To a lesser extent, PAP hydrolysis is also inhibited by Na(+) and K(+), with IC50 values of 150 and 250 mM, respectively, so much higher than IC50 with Li(+) (0.5 mM). Exhibits about 50% residual IMPase activity at 5 mM Li(+) and about 10% at 30 mM Li(+). Na(+) and K(+) have no significant effect on IMPase activity between 0 and 200 mM.PATHWAY Sulfur metabolism; sulfate assimilation.SUBUNIT Homodimer.INDUCTION When comparing gene expression levels of the four IMPase family genes in exponential cultures of M.tuberculosis, the level of cysQ is the highest, almost equal to sig…
organism: BioSource1

5'-Phosphoribosyl-5-amino-4-imidazolecarboxamide
type: SmallMoleculeReference
name: 5-Phosphoribosyl-4-carbamoyl-5-aminoimidazole
name: 5-Aminoimidazole-4-carboxamide ribotide
name: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide [ChEBI:18406]
name: 5'-Phospho-ribosyl-5-amino-4-imidazole carboxamide
name: 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
name: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
name: AICAR
name: 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide
xref: UnificationXref1911

a-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme
type: SmallMoleculeReference
name: Calomide
name: (5,6-dimethylbenzimidazolyl)cobamide coenzyme
name: 5'-Deoxy-5'-adenosyl vitamin B12
name: 5,6-Dimethylbenzimidazolyl-Co-5'-deoxy-5'-adenosylcobamide
name: Cobamide coenzyme [ChEBI:18408]
name: Funacomide
name: Coenzyme B12
name: Vitamin B12 coenzyme
name: Adenosylcobalamin
name: Cobalamin coenzyme
name: Deoxyadenosylcobalamin
name: Dibencozide
name: 5'-Deoxy-5'-adenosyl-5,6-dimethylbenzimidazolylcobamide
name: (5'-Deoxy-5'-adenosyl)cobamide coenzyme
name: DMBC coenzyme
name: 5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide
name: Cobamide coenzyme
name: Cobamamide
name: 5'-Deoxy-5'-adenosylcobalamin
xref: UnificationXref989

http://identifiers.org/pubmed/18515354
type: PublicationXref
id: 18515354
author: Coggan, M
author: Liu, D
author: Yamada, T
author: Board, PG
author: Clark, AG
author: Oakley, AJ
db: Pubmed
title: The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle
source: J Biol Chem 283:22031-42
year: 2008

5'-Phosphoribosylformylglycinamidine
type: SmallMoleculeReference
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
name: 1-(5'-Phosphoribosyl)-N-formylglycinamidine
name: 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
name: 5'-Phosphoribosylformylglycinamidine [ChEBI:18413]
name: 5'-Phosphoribosyl-N-formylglycinamidine
xref: UnificationXref1893

UnificationXref1210
type: UnificationXref
id: 390409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390409

UnificationXref1212
type: UnificationXref
id: 4235028
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235028

UnificationXref1211
type: UnificationXref
id: REACT_17713
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17713.2

UnificationXref1214
type: UnificationXref
id: 4236111
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236111

Evidence408
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9706223
comment: Carnitine is synthesized in four steps from trimethyllysine (generated in turn by the S-adenosyl-methionine-mediated methylation of lysine residues in proteins, followed by protein hydrolysis). The enzymes that catalyze the first three steps of carnitine synthesis, converting trimethyllysine to gamma-butyrobetaine, are widely distributed in human tissues. The enzyme that catalyzes the last reaction, converting gamma-butyrobetaine to carnitine, is found only in liver and kidney cells, and at very low levels in brain tissues. Other tissues that require carnitine, such as muscle, are dependent on transport systems that mediate its export from the liver and uptake by other tissues (Kerner and Hoppel 1998).

UnificationXref1213
type: UnificationXref
id: REACT_115040
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115040.8

Evidence409
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3091600
xref: http://identifiers.org/pubmed/22464254
xref: http://identifiers.org/pubmed/6785752
comment: MTA phosphorylase catalyzes the cleavage of adenine from S-methylthioadenosine (MTA) and subsequent phosphorylation of the product, yielding 5'-methylthio ribose-1-phosphate (Kamatani et al. 1981). The active form of the enzyme is a homotrimer (Della Ragione et al. 1985). Mutations in the gene are associated with a rare bone dysplasia and cancer syndrome, DMS-MFH (Camacho-Vanegas et al. 2012).

UnificationXref1216
type: UnificationXref
id: CHEBI:151
db: ChEBI

Evidence406
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref592
comment: The urea cycle yields urea, the major form in which excess nitrogen is excreted from the human body, and the amino acid arginine (Brusilow and Horwich 2001). It consists of four reactions: that of ornithine and carbamoyl phosphate to form citrulline, of citrulline and aspartate to form argininosuccinate, the cleavage of argininosuccinate to yield fumarate and arginine, and the cleavage of arginine to yield urea and re-form ornithine. The carbamoyl phosphate consumed in this cycle is synthesized in the mitochondria from bicarbonate and ammonia, and this synthesis in turn is dependent on the presence of N-acetylglutamate, which allosterically activates carbamoyl synthetase I enzyme. The synthesis of N-acetylglutamate is stimulated by high levels of arginine. Increased levels of free amino acids, indicated by elevated arginine levels, thus stimulate urea synthesis. Two enzymes catalyze the hydrolysis of arginine to yield ornithine and urea. Cytosolic ARG1 is the canonical urea cycle enzyme. Mitochondrial ARG2 likewise catalyzes urea production from arginine and may have a substantial sparing effect in patients lacking ARG1 enzyme, so its reaction is annotated here although the role of ARG2 under normal physiological conditions remains unclear.

UnificationXref1215
type: UnificationXref
id: REACT_112332
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112332.8

Evidence407
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/627563
comment: Cytosolic serine hydroxymethyltransferase tetramer (SHMT1) catalyzes the reaction of 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine to form glycine and 4-trimethylammoniobutanal (Hulse et al. 1978).

UnificationXref1218
type: UnificationXref
id: REACT_17953
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17953.2

Evidence404
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19006241
xref: http://identifiers.org/pubmed/518841
xref: http://identifiers.org/pubmed/18323623
comment: Cytosolic argininosuccinate synthase catalyzes the reaction of aspartate, citrulline, and ATP to form argininosuccinate, AMP, and pyrophosphate. The function of the human enzyme in vivo is inferred from the hypercitrullinemia observed in patients with defective forms of the enzyme (e.g., Engel et al. 2009). The enzyme is active as a homotetramer (OâBrien 1980; Karlberg et al. 2008).

UnificationXref1217
type: UnificationXref
id: 389548
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389548

Evidence405
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9256435
xref: http://identifiers.org/pubmed/2263616
comment: Cytosolic argininosuccinate lyase (ASL) catalyzes the reversible reaction of argininosuccinate to form fumarate and arginine. The enzyme is a homotetramer (Turner et al. 1997). The function of the human enzyme in vivo is inferred from the defective argininosuccinate lyase enzyme activity observed in patients with mutant forms of the ASL gene (e.g., Walker et al. 1990).

Evidence402
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6249820
comment: At the beginning of this reaction, 1 molecule of 'NH4+', 1 molecule of 'HCO3-', and 1 molecule of 'ATP' are present. At the end of this reaction, 1 molecule of 'Carbamoyl phosphate', 1 molecule of 'ADP', and 1 molecule of 'Orthophosphate' are present. This reaction takes place in the 'mitochondrial matrix' and is mediated by the 'carbamoyl-phosphate synthase (ammonia) activity' of 'carbamoyl-phosphate synthetase I dimer'.

UnificationXref1219
type: UnificationXref
id: 389556
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389556

Evidence403
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11237854
xref: http://identifiers.org/pubmed/6372096
comment: Mitochondrial ornithine transcarbamoylase (OTC) catalyzes the reaction of ornithine and carbamoyl phosphate to form citrulline (Horwich et al. 1984). The enzyme is a homotrimer (Shi et al. 2001).

UniProt:P96284
type: ProteinReference
xref: UnificationXref657
organism: BioSource1

Evidence400
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9700195
xref: http://identifiers.org/pubmed/8621661
xref: http://identifiers.org/pubmed/3944130
comment: Mitochondrial delta-1-pyrroline-5-carboxylate dehydrogenase (ALDH4A1) catalyzes the reaction of L-glutamate gamma-semialdehyde and NAD+ to form glutamate and NADH + H+ (Hu et al. 1996). The enzyme is a dimer (Forte-McRobbie and Pietruszko 1986). ALDH4A1 mutations cause type II hyperprolinemia in vivo (Geraghty et al. 1998).

UniProt:P96285
type: ProteinReference
xref: UnificationXref683
organism: BioSource1

Evidence401
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref583
comment: Proline is catabolized in two steps to yield L-glutamate gamma-semialdehyde, which can react further with glutamate to yield ornithine and alpha-ketoglutarate (annotated as a reaction of amino acid synthesis and interconversion) or with NAD+ to yield glutamate and NADH + H+ (Phang et al. 2001).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O05919
data source: Provenance1
name: 2,4- dienoyl-CoA reductase (NADPH)
name: 2,4-dienoyl-CoA reductase, mitochondrial precursor
name: O05919
name: 4-enoyl-CoA reductase (NADPH)
xref: UnificationXref966
feature: FragmentFeature89
cellular location: GO:0005622
comment: Reactome DB_ID: 4234242
display name: DECR1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P63577
data source: Provenance1
name: MMAA_HUMAN
name: Methylmalonic aciduria type A protein, mitochondrial ecNumber3.6.-.-/ecNumber
name: P63577
xref: UnificationXref994
feature: FragmentFeature93
cellular location: GO:0005622
comment: Reactome DB_ID: 4233799
display name: MMAA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P65487
data source: Provenance1
name: MCM
name: Methylmalonyl-CoA mutase, mitochondrial precursor
name: P65487
name: methylmalonyl-CoA mutase, apoprotein
name: MUTA_HUMAN
xref: UnificationXref988
feature: FragmentFeature92
cellular location: GO:0005622
comment: Reactome DB_ID: 4233803
display name: MUT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8VK36
data source: Provenance1
name: Q8VK36
name: methylmalonyl-CoA epimerase
name: methylmalonyl-CoA racemase
xref: UnificationXref984
feature: FragmentFeature91
cellular location: GO:0005622
comment: Reactome DB_ID: 4233812
display name: MCEE

P71871
type: Protein
entity reference: P71871
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: 2,4- dienoyl-CoA reductase (NADPH)
name: 2,4-dienoyl-CoA reductase, mitochondrial precursor
name: 4-enoyl-CoA reductase (NADPH)
xref: UnificationXref968
feature: FragmentFeature90
cellular location: GO:0005622
comment: Reactome DB_ID: 4234245
display name: DECR1

UnificationXref1225
type: UnificationXref
id: CHEBI:30915
db: ChEBI

UnificationXref1224
type: UnificationXref
id: REACT_10257
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10257.1

http://identifiers.org/pubmed/19247306
type: PublicationXref
id: 19247306
author: Beenken, A
author: Mohammadi, M
db: Pubmed
title: The FGF family: biology, pathophysiology and therapy
source: Nat Rev Drug Discov 8:235-53
year: 2009

UnificationXref1223
type: UnificationXref
id: 193465
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193465

UnificationXref1222
type: UnificationXref
id: REACT_5821
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5821.1

UnificationXref1221
type: UnificationXref
id: 113602
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113602

UnificationXref1220
type: UnificationXref
id: REACT_17375
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17375.1

UniProt:P96271
type: ProteinReference
xref: UnificationXref3694
organism: BioSource1

Evidence433
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11032836
comment: Lead binds to ALAD enzyme displacing half the zinc ions essential for its catalytic activity and inactivating it. Lead is a major environmental toxin and this enzyme is one of its principal molecular targets (Jaffe et al. 2001).

Evidence434
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11032841
xref: http://identifiers.org/pubmed/10706561
xref: http://identifiers.org/pubmed/11032836
xref: http://identifiers.org/pubmed/7354072
xref: http://identifiers.org/pubmed/15381398
comment: 5-Aminolevulinic acid dehydratase (ALAD aka porphobilinogen synthase, PBGS), catalyzes the asymmetric condensation of two molecules of ALA to form porphobilinogen (PBG). The substrate that becomes the acetyl side chain-containing half of PBG is called A-side ALA; the half that becomes the propionyl side chains and the pyrrole nitrogen is called P-ALA (Jaffe 2004). PBG is the first pyrrole formed, the precursor to all tetrapyrrole pigments such as heme and chlorophyll. There are at least eight bonds that are made or broken during this reaction. The active form of the ALAD enzyme is an octamer complexed with eight Zn2+ ions, four that are strongly bound and four that are weakly bound. The four weakly bound ones are dispensible for enzyme activity in vitro (Bevan et al. 1980; Mitchell et al. 2001). Deficiencies of ALAD enzyme in vivo are associated with 5-aminolevulinate dehydratase-deficient porphyria (e.g., Akagi et al. 2000).

Evidence435
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/7354069
xref: http://identifiers.org/pubmed/12773194
comment: Cytosolic porphobilinogen deaminase catalyzes the polymerization of four molecules of porphobilinogen (PBG) to generate hydroxymethylbilane (HMB), an unstable tetrapyrrole. This reaction is the first step in the formation of the tetrapyrrole macrocycle. Two isoforms of porphobilinogen deaminase are generated by alternative splicing, one expresssed in erythroid tissues and one ubiquitously expressed in the body. Deficiencies of both forms of PBG deaminase are associated with acute intermittent porphyria.

Evidence436
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9564029
xref: http://identifiers.org/pubmed/8644733
xref: http://identifiers.org/pubmed/6822570
comment: Cytosolic uroporphyrinogen decarboxylase (UROD) catalyzes the sequntial removal of four carboxylic groups from the acetic acid side chains of uroporphyrinogen III (URO3) to form coproporphyrinogen III (COPRO3) (de Verneuil et al. 1983). Human UROD is a dimer (Whitby et al. 1998). Heterogenous and homogenous deficiencies of UROD are associated with porphyria cutanea tarda and hepatoerythropoietic porphyria respectively in vivo (Moran-Jiminez et al. 1996).

UnificationXref1229
type: UnificationXref
id: REACT_17799
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17799.1

Homologues of AMACR(1-382)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1139
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234576

Evidence437
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9564029
xref: http://identifiers.org/pubmed/8644733
xref: http://identifiers.org/pubmed/6822570
comment: Cytosolic uroporphyrinogen decarboxylase (UROD) catalyzes the sequential removal of four carboxylic groups from the acetic acid side chains of uroporphyrinogen I (URO1) to form coproporphyrinogen I (COPRO1). UROD catalyzes this reaction less efficiently than the decarboxylation of uroporphyrinogen III (de Verneuil et al. 1983).

UnificationXref1228
type: UnificationXref
id: 389536
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389536

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53867
data source: Provenance1
name: Alpha-methylacyl-CoA racemase
name: AMACR(1-382)
name: O53867
xref: UnificationXref1136
feature: FragmentFeature111
cellular location: GO:0005622
comment: Reactome DB_ID: 4234572
display name: AMACR

Evidence438
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8771201
comment: Six electrons are oxidized in protophorphyrinogen IX (PPGEN9) to form the planar macrocycle protoporphyrin IX (PRIN9). This reaction is performed by the enzyme protoporphyrinogen oxidase (PPO). PPO functions as a homodimer containing one non-covalently-bound FAD. The protein resides on the outer surface of the inner mitochondrial membrane. PPO deficiency is associated with variegate porphyria in vivo.

UnificationXref1227
type: UnificationXref
id: REACT_17938
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17938.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O06543
data source: Provenance1
name: O06543
name: Alpha-methylacyl-CoA racemase
name: AMACR(1-382)
xref: UnificationXref1138
feature: FragmentFeature112
cellular location: GO:0005622
comment: Reactome DB_ID: 4234575
display name: AMACR

Evidence439
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11175906
xref: http://identifiers.org/pubmed/3327432
comment: Ferrochelatase (FECH) catalyzes the insertion of ferrous iron into protoporphyrin IX (PRIN9) to form heme. FECH is localized on the matrix surface of the inner mitochondrial membrane and this reaction takes place within the mitochondrial matrix. The enzyme functions as a homodimer with each monomer containing a nitric oxide-sensitive 2Fe-2S cluster. Enzyme deficiency is associated with erythropoietic protoporphyria in vivo, and inhibition of ferrochelatase activity is a clinically important consequence of lead poisoning (Piomelli et al. 1987).

UnificationXref1226
type: UnificationXref
id: 389537
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389537

Homologues of AGPS
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1196
cellular location: GO:0005622
comment: Reactome DB_ID: 4234147
comment: Converted from EntitySet in Reactome

Q50614
type: Protein
entity reference: Q50614
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ABCD1
xref: UnificationXref1177
feature: FragmentFeature116
cellular location: GO:0005622
comment: Reactome DB_ID: 4234973
display name: ALDP

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O05784
data source: Provenance1
name: Alkyldihydroxyacetonephosphate synthase, peroxisomal precursor
name: O05784
name: Alkyl-DHAP synthase
name: Alkylglycerone phosphate synthase
name: Alkyldihydroxyacetonephosphate synthase precursor
xref: UnificationXref1195
feature: FragmentFeature118
cellular location: GO:0005622
comment: Reactome DB_ID: 4234146
display name: AGPS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53525
data source: Provenance1
name: O53525
name: Alkyldihydroxyacetonephosphate synthase, peroxisomal precursor
name: Alkyl-DHAP synthase
name: Alkylglycerone phosphate synthase
name: Alkyldihydroxyacetonephosphate synthase precursor
xref: UnificationXref1193
feature: FragmentFeature117
cellular location: GO:0005622
comment: Reactome DB_ID: 4234143
display name: AGPS

Homologues of ACOT8
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1166
cellular location: GO:0005622
comment: Reactome DB_ID: 4234630
comment: Converted from EntitySet in Reactome

Evidence430
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/20162368
comment: While in humans excess methionine is converted to homocysteine, homocysteine and its transsulfuration product cysteine can be degraded to several end products, two of which, taurine and hydrogen sulfide, have uses in other biological processes (Stipanuk & Ueki 2011).

http://identifiers.org/pubmed/20494107
type: PublicationXref
id: 20494107
author: Schnell, R
author: Schneider, G
db: Pubmed
title: Structural enzymology of sulphur metabolism in Mycobacterium tuberculosis
source: Biochem Biophys Res Commun 396:33-8
year: 2010

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O33332
data source: Provenance1
name: Sterol carrier protein 2 isoform 1
name: SCP2-1
name: O33332
xref: UnificationXref1152
feature: FragmentFeature113
cellular location: GO:0005622
comment: Reactome DB_ID: 4234590
display name: SCPx

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O06209
data source: Provenance1
name: Acyl-coenzyme A thioesterase 8
name: O06209
xref: UnificationXref1165
feature: FragmentFeature115
cellular location: GO:0005622
comment: Reactome DB_ID: 4234629
display name: ACOT8

Evidence432
type: Evidence
evidence code: inferred from electronic annotation
comment: This group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amino acids that are not essential components of the human diet; and 4) the synthesis of related nitrogen-containing molecules including carnitine and creatine. Transport of these molecuels across lipid bilayer membranes is annotated separately as part of the module on "transmembrane transport of small molecules".

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O06135
data source: Provenance1
name: O06135
name: Acyl-coenzyme A thioesterase 8
xref: UnificationXref1163
feature: FragmentFeature114
cellular location: GO:0005622
comment: Reactome DB_ID: 4234626
display name: ACOT8

Evidence431
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16702333
comment: The main sulfur amino acids are methionine, cysteine, homocysteine and taurine. Of these, the first two are proteinogenic. This group of reactions contains all processes that 1) break down sulfur amino acids, 2) interconvert between them, and 3) synthesize them from solved sulfide which comes from sulfate assimilation and reduction. Only plants and microorganisms employ all processes. Humans cannot de novo synthesize any sulfur amino acid, nor convert cysteine to methionine (Brosnan & Brosnan, 2006).

UnificationXref1234
type: UnificationXref
id: REACT_104821
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104821.9

UnificationXref1233
type: UnificationXref
id: 4234989
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234989

UnificationXref1236
type: UnificationXref
id: REACT_17299
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17299.2

UnificationXref1235
type: UnificationXref
id: 389545
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389545

UnificationXref1230
type: UnificationXref
id: P65097
db: UniProt

UnificationXref1232
type: UnificationXref
id: 4234986
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234986

UnificationXref1231
type: UnificationXref
id: 4234985
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234985

Evidence424
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10212249
xref: http://identifiers.org/pubmed/19261609
comment: Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

Evidence425
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10212249
xref: http://identifiers.org/pubmed/19261609
comment: alpha,beta-elimination activity of cystathionine-gamma-lyase (CTH) replaces the sulfur in cysteine with oxygen from water, resulting in serine and toxic hydrogen sulfide, which is further oxidized in mitochondria (Chiku et al. 2009, Steegborn et al. 1999).

http://identifiers.org/pubmed/10949035
type: PublicationXref
id: 10949035
author: Pandit, J
author: Mansour, MN
author: Schulte, GK
author: Rath, VL
author: Wasilko, DJ
author: LeMotte, PK
author: Danley, DE
author: Fennell, KF
author: Hynes, TR
author: Ammirati, M
db: Pubmed
title: Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core
source: Mol Cell 6:139-48
year: 2000

Evidence422
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15497768
xref: http://identifiers.org/pubmed/20817827
comment: Transsulfuration is the interconversion of homocysteine and cysteine, and it fully takes place in bacteria and some plants and fungi. Animals however have only one direction of this bidirectional path, the synthesis of cysteine from homocysteine via cystathionine. Because excess cysteine is degraded to hydrogen sulfide, which is now known as a neuromodulator and smooth muscle relaxant, this pathway is also the main source of its production, which takes place in the cytosol, as well as in extracellular space (Dominy & Stipanuk 2004, Bearden et al. 2010).

Evidence423
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12473676
comment: A cytosolic, non-specific peptidase can hydrolyze cysteinylglycine to release cysteine and glycine (Tuefel et al, 2003).

UnificationXref1238
type: UnificationXref
id: REACT_5182
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5182.4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P72007
data source: Provenance1
name: SLC27A1
name: S27A1_HUMAN
name: Long-chain fatty acid transport protein 1
name: P72007
xref: UnificationXref1065
feature: FragmentFeature103
cellular location: GO:0005886
comment: Reactome DB_ID: 4235224
display name: FATP1

Evidence428
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18494801
xref: http://identifiers.org/pubmed/12832624
comment: When SQR is in the oxidized state, it can bind hydrogen sulfide as persulfide to one of its own cysteine residue, the electrons being transferred to ubiquinone. After that the additional sulfur is dioxygenated by another enzyme (ETHE1). The activity of human SQR was deduced from the orthologue in Arenicola marina (Theissen et al. 2003, Hildebrandt & Grieshaber 2008).

UnificationXref1237
type: UnificationXref
id: 29406
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29406

O05307
type: Protein
entity reference: O05307
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SLC27A1
name: S27A1_HUMAN
name: Long-chain fatty acid transport protein 1
xref: UnificationXref1067
feature: FragmentFeature104
cellular location: GO:0005886
comment: Reactome DB_ID: 4235225
display name: FATP1

Evidence429
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/20162368
comment: While the human body is very economical with sulfur amino acids (SAA), superfluous SAA are degraded via cysteine to toxic hydrogen sulfide which must be dealt with. The pathway to oxidize this gas is localized to mitochondria and is highly conserved, pointing back to a time when life was immersed in sulfide-rich waters. The pathway for sulfide oxidation consists of five reactions, one of which, the sulfur transfer from thiosulfate to glutathione, is still to be characterized fully. A mutation in one enzyme has been identified that is associated with ethylmalonyl encephalopathy and where tissue sulfide is elevated (Stipanuk & Ueki 2011).

Homologues of SLC27A1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: O05307
xref: UnificationXref1070
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4235227

Evidence426
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10212249
xref: http://identifiers.org/pubmed/19261609
comment: Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

UnificationXref1239
type: UnificationXref
id: 4234988
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234988

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O33185
data source: Provenance1
name: SLC27A1
name: S27A1_HUMAN
name: Long-chain fatty acid transport protein 1
name: O33185
xref: UnificationXref1063
feature: FragmentFeature102
cellular location: GO:0005886
comment: Reactome DB_ID: 4235223
display name: FATP1

Evidence427
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10212249
xref: http://identifiers.org/pubmed/19261609
comment: Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

2-hydroxyphytanoyl-CoA lyase
type: Protein
entity reference: O53639
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: O53639
name: 2-hydroxyacyl-CoA lyase 1
xref: UnificationXref1115
feature: FragmentFeature110
cellular location: GO:0005622
comment: Reactome DB_ID: 4234992
display name: HACL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53551
data source: Provenance1
name: O53551
name: Very long-chain acyl-CoA synthetase
name: SLC27A2
xref: UnificationXref1098
feature: FragmentFeature109
cellular location: GO:0005622
comment: Reactome DB_ID: 4234636
display name: VLCS

O05307
type: Protein
entity reference: O05307
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Very long-chain acyl-CoA synthetase
name: SLC27A2
xref: UnificationXref1097
feature: FragmentFeature108
cellular location: GO:0005622
comment: Reactome DB_ID: 4234635
display name: VLCS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P72007
data source: Provenance1
name: Very long-chain acyl-CoA synthetase
name: P72007
name: SLC27A2
xref: UnificationXref1096
feature: FragmentFeature107
cellular location: GO:0005622
comment: Reactome DB_ID: 4234634
display name: VLCS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:O33185
data source: Provenance1
name: O33185
name: Very long-chain acyl-CoA synthetase
name: SLC27A2
xref: UnificationXref1095
feature: FragmentFeature106
cellular location: GO:0005622
comment: Reactome DB_ID: 4234633
display name: VLCS

Evidence421
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10212249
xref: http://identifiers.org/pubmed/19261609
comment: Cystathionine is cleaved to cysteine, oxobutanoate, and ammonia by the alpha,gamma-elimination activity of cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999).

Homologues of SLC27A2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: O05307
xref: UnificationXref1099
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234637

Evidence420
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11524006
comment: The first step of homocysteine conversion to cysteine is catalyzed by cystathionine beta-lyase, which adds a serine molecule to the substrate. The enzyme is a tetramer with two heme molecules as cofactor (Janosik et al. 2001).

HDL-mediated lipid transport
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction48
evidence: Evidence100
xref: RelationshipXref90
xref: UnificationXref624
xref: UnificationXref623
pathway order: PathwayStep97
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53551
data source: Provenance1
name: SLC27A1
name: O53551
name: S27A1_HUMAN
name: Long-chain fatty acid transport protein 1
xref: UnificationXref1069
feature: FragmentFeature105
cellular location: GO:0005886
comment: Reactome DB_ID: 4235226
display name: FATP1

UnificationXref656
type: UnificationXref
id: 4234057
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234057

UnificationXref657
type: UnificationXref
id: P96284
db: UniProt

UnificationXref658
type: UnificationXref
id: 4234061
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234061

UnificationXref659
type: UnificationXref
id: Q10978
db: UniProt

UnificationXref652
type: UnificationXref
id: P96203
db: UniProt

UnificationXref653
type: UnificationXref
id: MOD:00159
db: MOD

UnificationXref654
type: UnificationXref
id: 4234053
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234053

UnificationXref655
type: UnificationXref
id: P94996
db: UniProt

Evidence453
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6788990
comment: At the beginning of this reaction, 1 molecule of 'Oxygen', 1 molecule of 'H2O', and 1 molecule of '2-Phenylethylamine' are present. At the end of this reaction, 1 molecule of 'NH3', 1 molecule of 'H2O2', and 1 molecule of 'Phenylacetaldehyde' are present. This reaction takes place in the 'mitochondrial outer membrane' and is mediated by the 'amine oxidase activity' of 'MAOB-FAD complex'.

Evidence454
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9443166
xref: http://identifiers.org/pubmed/11468017
comment: Human monoamine oxidases (MAOs) are flavin-containing enzymes that are present on the outer mitochondrial membrane and act on primary, secondary and tertiary amines. In contrast to the P450s which have a large number of isozymes, MAOs number only two isozymes, MAO-A and MAO-B. These gene products share over 70% sequence identity, are approximately 59KDa in size and have overlapping substrates (for example dopamine, tryamine and tryptamine) but each form also has distinct substrate specificities. MAO-A (primary type in fibroblasts) preferentially oxidises serotonin (5-Hydroxytryptamine) whereas MAO-B (primary type in platelets) prefers phenylethylamine. MAOs are of particular clinical interest because of the use of MAO inhibitors (MAOI) as antidepressants or in the treatment of neurodegenerative diseases.

Evidence451
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/4016087
comment: Monoamine oxidases (MAO-A/B), present in the outer mitochondrial membrane, catalyze the oxidation of biogenic amines, releasing hydrogen peroxide (H2O2). H2O2 produced during the oxidative deamination of these amines appears to be involved in the progress of neurodegenerative disorders such as Parkinson disease, presumably via oxidative damage to the mitochondrial membrane.

Evidence452
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6408492
comment: At the beginning of this reaction, 1 molecule of 'Oxygen', 1 molecule of 'H2O', and 1 molecule of '5-Hydroxytryptamine' are present. At the end of this reaction, 1 molecule of 'NH3', 1 molecule of '5-Hydroxyindoleacetaldehyde', and 1 molecule of 'H2O2' are present. This reaction takes place in the 'mitochondrial outer membrane' and is mediated by the 'amine oxidase activity' of 'MAOA-FAD complex'.

UnificationXref4399
type: UnificationXref
id: 4235063
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235063

Evidence450
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16584116
xref: http://identifiers.org/pubmed/15128046
xref: http://identifiers.org/pubmed/15102545
xref: http://identifiers.org/pubmed/12369887
comment: The P450 isozyme system is the major phase 1 biotransforming system in man, accounting for more than 90% of drug biotransformations. This system has huge catalytic versatility and a broad substrate specificity, acting upon xenobiotica and endogenous compounds. It is also called the mixed-function oxidase system, the P450 monooxygenases and the heme-thiolate protein system. All P450 enzymes are a group of heme-containing isozymes which are located on the membrane of the smooth endoplasmic reticulum. They can be found in all tissues of the human body but are most concentrated in the liver. The name "cytochrome P450" (CYP) is derived from the spectral absorbance maximum at 450nm when carbon monoxide binds to CYP in its reduced (ferrous, Fe2+) state. The basic reaction catalyzed by CYP is mono-oxygenation, that is the transfer of one oxygen atom from molecular oxygen to a substrate. The other oxygen atom is reduced to water during the reaction with the equivalents coming from the cofactor NADPH. The basic reaction is; RH (substrate) + O2 + NADPH + H+ = ROH (product) + H2O + NADP+ The end results of this reaction can be (N-)hydroxylation, epoxidation, heteroatom (N-, S-) oxygenation, heteroatom (N-, S-, O-) dealkylation, ester cleavage, isomerization, dehydrogenation, replacement by oxygen or even reduction under anaerobic conditions. The metabolites produced from these reactions can either be mere intermediates which have relatively little reactivity towards cellular sysytems and are readily conjugated, or, they can be disruptive to cellular systems. Indeed, inert compounds need to be prepared for conjugation and thus the formation of potentially reactive metabolites is in most cases unavoidable. There are 57 human CYPs (in 18 families and 42 subfamilies), mostly concentrated in the endoplasmic reticulum of liver cells although many tissues have them to some extent (Nelson DR et al, 2004). CYPs are grouped into 14 families according to their sequence similarity. General…

UnificationXref4398
type: UnificationXref
id: 4235061
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235061

UnificationXref4397
type: UnificationXref
id: REACT_20087
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20087.2

http://identifiers.org/pubmed/20494131
type: PublicationXref
id: 20494131
author: Welin, M
author: Nordlund, P
db: Pubmed
title: Understanding specificity in metabolic pathways--structural biology of human nucleotide metabolism
source: Biochem Biophys Res Commun 396:157-63
year: 2010

UnificationXref4395
type: UnificationXref
id: REACT_19509
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19509.1

UnificationXref1248
type: UnificationXref
id: 191324
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191324

UnificationXref4396
type: UnificationXref
id: 425971
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425971

UnificationXref1249
type: UnificationXref
id: REACT_9855
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9855.2

UnificationXref4393
type: UnificationXref
id: GO:0031905
db: GENE ONTOLOGY

UnificationXref4394
type: UnificationXref
id: 425978
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425978

Evidence459
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16584116
xref: http://identifiers.org/pubmed/17125408
xref: http://identifiers.org/pubmed/12369887
xref: PublicationXref668
comment: Phase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conjugating species with which to react with. Many xenobiotics are lipophilic and almost chemically inert (e.g. PAHs) so would not necessarily undergo a phase 2 reaction. Making them more chemically reactive would facilitate their excretion but also increases their chance of reacting with cellular macromolecules (e.g. proteins, DNA). There is a fine balance between producing a more reactive metabolite and conjugation reactions. There are two groups of enzymes in phase 1 - oxidoreductases and hydrolases. Oxidoreductases introduce an oxygen atom into or remove electrons from their substrates. The major oxidoreductase enzyme system is called the P450 monooxygenases. Other systems include flavin-containing monooxygenases (FMO), cyclooxygenases (COX) and monoamine oxidases (MAO). Hydrolases hydrolyse esters, amides, epoxides and glucuronides.

UnificationXref4391
type: UnificationXref
id: 4235071
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235071

Evidence458
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17567461
xref: http://identifiers.org/pubmed/9982
xref: http://identifiers.org/pubmed/2729894
xref: http://identifiers.org/pubmed/3893466
xref: http://identifiers.org/pubmed/10441588
xref: http://identifiers.org/pubmed/18110463
xref: http://identifiers.org/pubmed/224930
comment: Ethanol and related alcohols can be ingested as part of the diet and are formed by microorganisms in the intestinal tract. Ethanol oxidation to acetate occurs primarily in liver cells in a multistep process first described by Racker (1949). First, in the cytosol, ethanol is oxidized to acetaldehyde, with the formation of NADH. Second, in the mitochondrion, acetaldehyde is oxidized to acetate with the formation of NADH. Finally, acetate in the mitochondrion can be condensed with coenzyme A to form acetyl CoA. Polymorphisms in the enzymes catalyzing the first two steps are associated with variation in the efficiency of alcohol catabolism in human populations (Chen et al. 1999; Lange et al. 1976; Jornvall 1985). The molecular mechanism by which cytosolic acetaldehyde enters the mitochondrial matrix is not known (Lemasters 2007). Cytosolic enzymes capable of oxidizing acetaldehyde to acetate have also been identified and characterized in vitro (Inoue et al. 1979) so a purely cytosolic pathway for ethanol oxidation to acetate and conversion to acetyl-CoA can be annotated. The role of this pathway in vivo is unclear, though limited attempts to correlate deficiencies in the cytosolic enzyme with alcohol intolerance have yielded suggestive data (Yoshida et al. 1989). Additional peroxisomal and microsomal pathways for the oxidation of ethanol to acetaldehyde have been described; their physiological significance is unclear and they are not annotated here.

UnificationXref4392
type: UnificationXref
id: REACT_100724
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100724.9

Evidence457
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10843999
comment: Cytosolic ACSS2 (acetyl-coenzyme A synthetase) catalyzes the reaction of acetate, coenzyme A, and ATP to form acetyl-CoA, AMP, and pyrophosphate (Luong et al. 2000).

http://identifiers.org/pubmed/17567461
type: PublicationXref
id: 17567461
author: Lemasters, JJ
db: Pubmed
title: Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism
source: J Gastroenterol Hepatol 22:S31-7
year: 2007

Evidence456
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16788062
comment: ACSS1 (acyl-CoA synthetase short-chain family member 1) in the mitochondrial matrix catalyzes the reaction of acetate, coenzyme A, and ATP to form acetyl-CoA, AMP, and pyrophosphate (Schwer et al. 2006).

UnificationXref4390
type: UnificationXref
id: 4235069
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235069

Evidence455
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9443166
xref: http://identifiers.org/pubmed/11468017
xref: http://identifiers.org/pubmed/6206782
comment: Human amine oxidases (AO) catalyze the oxidative deamination of biogenic amines (neurotransmitters such as serotonin, noradrenaline, the hormone adrenaline and polyamines such as the spermines) and xenobiotic amines (exogenous dietary tyramine and phenylethylamine). The basic reaction is the oxidative cleavage of the alpha-H to form an imine product with the concomitant reduction of a FAD cofactor. The imine product then hydrolyses to an aldehyde and ammonia (or amine for secondary and tertiary amine substrates). Reduced FAD is reoxidized to form hydrogen peroxide to complete the catalytic cycle. The reaction can be summarized as RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2 The resultant hydrogen peroxide is the source of the most toxic free radical, the hydroxyl radical (.OH). This free radical is produced in the Fenton reaction with the use of ferrous (Fe2+) iron.

UnificationXref1240
type: UnificationXref
id: 4236241
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236241

UnificationXref660
type: UnificationXref
id: 4234065
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234065

UnificationXref1241
type: UnificationXref
id: REACT_103795
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103795.9

UnificationXref1242
type: UnificationXref
id: 4236112
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236112

UnificationXref662
type: UnificationXref
id: 4234069
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234069

UnificationXref1243
type: UnificationXref
id: REACT_84404
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_84404.9

UnificationXref661
type: UnificationXref
id: O06586
db: UniProt

UnificationXref1244
type: UnificationXref
id: CHEBI:16584
db: ChEBI

http://identifiers.org/pubmed/8694764
type: PublicationXref
id: 8694764
author: Bulleid, NJ
author: Wilson, R
author: Lees, JF
db: Pubmed
title: Type-III procollagen assembly in semi-intact cells: chain association, nucleation and triple-helix folding do not require formation of inter-chain disulphide bonds but triple-helix nucleation does require hydroxylation
source: Biochem J 317:195-202
year: 1996

UnificationXref1245
type: UnificationXref
id: 191362
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191362

UnificationXref1246
type: UnificationXref
id: REACT_9725
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9725.2

UnificationXref1247
type: UnificationXref
id: CHEBI:16057
db: ChEBI

UnificationXref669
type: UnificationXref
id: O53490
db: UniProt

UnificationXref667
type: UnificationXref
id: O53901
db: UniProt

UnificationXref668
type: UnificationXref
id: 4234081
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234081

UnificationXref1250
type: UnificationXref
id: P72002
db: UniProt

UnificationXref665
type: UnificationXref
id: P71718
db: UniProt

UnificationXref666
type: UnificationXref
id: 4234077
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234077

UnificationXref663
type: UnificationXref
id: Q10977
db: UniProt

UnificationXref664
type: UnificationXref
id: 4234073
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234073

Evidence440
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8078902
xref: http://identifiers.org/pubmed/9177788
comment: Heme O and heme A are specifically synthesised for the heme-copper respiratory oxidases. Mitochondrial protoheme IX farnesyltransferase (COX10) mediates the transformation of protoheme IX (heme) and farnesyl diphosphate (FAPP) to heme O (Glerum & Tzagoloff 1994). COX10 is highly expressed in muscle, heart and brain (Murakami et al. 1997).

Evidence441
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16839620
xref: http://identifiers.org/pubmed/10522552
comment: Eight enzymes are involved in heme biosynthesis, four each in the mitochondria and the cytosol. The process starts in the mitochondria with the condensation of succinyl CoA (from the TCA cycle) and glycine to form 5-aminolevulinate (ALA). The next four steps take place in the cytosol. Two molecules of ALA are condensed to form the monopyrrole porphobilinogen (PBG). The next two steps convert four molecules of PBG into the cyclic tetrapyrrole uroporphyringen III, which is then decarboxylated into coproporphyrinogen III. The last three steps occur in the mitochondria and involve modifications to the tetrapyrrole side chains and finally, insertion of iron. In addition to these synthetic steps, a spontaneous cytosolic reaction allows the formation of uroporphyringen I which is then enzymatically decarboxylated to coproporphyrinogen I, which cannot be metabolized further in humans. Also, lead can inactivate ALAD, the enzyme that catalyzes PBG synthesis, and ferrochelatase, the enzyme that catalyzes heme synthesis. The porphyrias are disorders that arise from defects in the enzymes of heme biosynthesis. Defective pathway enzymes after ALA synthase result in accumulated substrates which can cause either skin problems, neurological complications, or both due to their toxicity in higher concentrations. They are broadly classified as hepatic porphyrias or erythropoietic porphyrias, based on the site of the overproduction of the substrate. Each defect is described together with the reaction it affects.

Evidence442
type: Evidence
evidence code: inferred from electronic annotation
comment: Porphyrins are heterocyclic macrocycles, consisting of four pyrrole subunits (tetrapyrrole) linked by four methine (=CH-) bridges. The extensive conjugated porphyrin macrocycle is chromatic and the name itself, porphyrin, is derived from the Greek word for purple. The aromatic character of porphyrins can be seen by NMR spectroscopy. Porphyrins readily combine with metals by coordinating them in the central cavity. Iron (heme) and magnesium (chlorophyll) are two well known examples although zinc, copper, nickel and cobalt form other known metal-containing phorphyrins. A porphyrin which has no metal in the cavity is called a free base. Some iron-containing porphyrins are called hemes (heme-containing proteins or hemoproteins) and these are found extensively in nature ie. hemoglobin. Hemoglobin is quantitatively the most important hemoprotein. The hemoglobin iron is the transfer site of oxygen and carries it in the blood all round the body for cell respiration. Other examples are cytochromes present in mitochondria and endoplasmic reticulum which takes part in electron transfer events, catalase and peroxidase whic protect the body against the oxidant hydrogen peroxide and tryptophan oxygenase which is present in intermediary metabolism. Hemoproteins are synthesized in all mammalian cells and the major sites are erythropoietic tissue and the liver. The processes by which heme is synthesized, transported, and metabolized are a critical part of human iron metabolism (Severance and Hamze 2009); here the core processes of heme biosynthesis and catabolism have been annotated.

Evidence443
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10051404
comment: Cytochrome P450 8B1 (CYP8B1, sterol 12-alpha- hydroxylase) has a broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids. It is also involved in bile acid synthesis and is responsible for the balance between the formation of cholic acid and chenodeoxycholic acid.

Evidence449
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16584116
xref: http://identifiers.org/pubmed/15102545
comment: A number of CYPs can act upon vitamins.

Evidence448
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/14532297
comment: Endogenous retinoic acids (RA) which play a role in gene regulation exist as either cis or trans isomers. While CYP26C1 can also hydroxylate the trans form, it is unique in hydroxylating the 9-cis isomer of RA.

UnificationXref1259
type: UnificationXref
id: 29368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29368

Evidence445
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16584116
xref: http://identifiers.org/pubmed/15102545
xref: http://identifiers.org/pubmed/7922394
comment: Arachidonic acid is metabolized via three major enzymatic pathways: cyclooxygenase, lipoxygenase, and cytochrome P450. The cytochrome P450 pathway metabolites are oxygenated metabolites of arachidonic acid.

Evidence444
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16584116
xref: http://identifiers.org/pubmed/15102545
xref: http://identifiers.org/pubmed/16872679
comment: A number of CYPs take part in cholesterol biosynthesis and elimination, thus playing an important role in maintaining cholesterol homeostasis. Under normal physiological conditions, cholesterol intake (diet or synthesized de novo from acetyl CoA) equals cholesterol elimination (degraded to bile salts, secreted in bile and used in steroid hormone synthesis). These processes are under tight regulatory control and any disruption leads to increased cholesterol levels resulting in cardiovacular disease. The CYPs involved in cholesterol homeostasis could serve as potential targets for cholesterol-lowering drugs.

Evidence447
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10823918
comment: CYP26B1 can also deactivate all-trans-retinoic acid by 4-hydroxylation. High expression levels in the cerebellum and pons of human brain suggests a protective role of specific tissues against retinoid damage.

http://identifiers.org/pubmed/11524006
type: PublicationXref
id: 11524006
author: Gaustadnes, M
author: Janosík, M
author: Kery, V
author: Maclean, KN
author: Kraus, JP
db: Pubmed
title: Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region
source: Biochemistry 40:10625-33
year: 2001

Evidence446
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9716180
comment: Retinoic acid (RA) is a biologically active analogue of vitamin A (retinol). RA plays an important role in regulating cell growth and differentiation.CYP26A1 is involved in the metabolic breakdown of RA by 4-hydroxylation. CYP26A1-mediated 4-hydroxylation is specific for all-trans-RA but not for the isomers 13-cis-RA and 9-cis-RA.

UnificationXref1253
type: UnificationXref
id: 4234561
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234561

UnificationXref673
type: UnificationXref
id: P96204
db: UniProt

UnificationXref1254
type: UnificationXref
id: REACT_83548
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83548.9

UnificationXref672
type: UnificationXref
id: 4234089
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234089

UnificationXref1251
type: UnificationXref
id: 4234558
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234558

UnificationXref671
type: UnificationXref
id: O65933
db: UniProt

UnificationXref1252
type: UnificationXref
id: 4234559
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234559

UnificationXref670
type: UnificationXref
id: 4234085
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234085

UnificationXref1257
type: UnificationXref
id: REACT_10504
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10504.2

UnificationXref1258
type: UnificationXref
id: CHEBI:15379
db: ChEBI

UnificationXref1255
type: UnificationXref
id: CHEBI:16521
db: ChEBI

UnificationXref1256
type: UnificationXref
id: 194634
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194634

UnificationXref630
type: UnificationXref
id: 30495
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30495

UnificationXref631
type: UnificationXref
id: REACT_4160
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4160.2

UnificationXref1261
type: UnificationXref
id: CHEBI:30751
db: ChEBI

UnificationXref632
type: UnificationXref
id: 76116
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76116

UnificationXref1260
type: UnificationXref
id: REACT_5251
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5251.2

UnificationXref633
type: UnificationXref
id: REACT_3756
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3756.1

UnificationXref634
type: UnificationXref
id: O07427
db: UniProt

UnificationXref635
type: UnificationXref
id: 4234469
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234469

UnificationXref636
type: UnificationXref
id: 4234471
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234471

http://identifiers.org/pubmed/9395452
type: PublicationXref
id: 9395452
author: Cass, AE
author: Brown, KA
author: Nagy, JM
db: Pubmed
title: Purification and characterization of recombinant catalase-peroxidase, which confers isoniazid sensitivity in Mycobacterium tuberculosis
source: J Biol Chem 272:31265-71
year: 1997

UnificationXref637
type: UnificationXref
id: REACT_107190
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107190.9

UnificationXref638
type: UnificationXref
id: 4236189
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236189

Evidence471
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18515354
xref: http://identifiers.org/pubmed/17932939
comment: Gamma-glutamylcyclotransferase (GGCT) homodimer (Bae et al, 2008) catalyzes the formation of 5-oxoproline from gamma-glutamylcysteine and thus, may play a role in glutathione homeostasis (Oakley et al, 2008).

UnificationXref639
type: UnificationXref
id: REACT_80264
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80264.9

Evidence472
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18515354
xref: http://identifiers.org/pubmed/17932939
comment: Gamma-glutamylcyclotransferase (GGCT) homodimer (Bae et al, 2008) can catalyzes the formation of 5-oxoproline from gamma-glutamyl-amino acid products and thus can play a role in glutathione homeostasis (Oakley et al, 2008).

Evidence470
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref674
xref: http://identifiers.org/pubmed/10898761
xref: http://identifiers.org/pubmed/15130560
xref: http://identifiers.org/pubmed/10331075
comment: Methylation is a common but minor pathway of Phase II conjugation compared to glucuronidation or sulfonation. The cofactor used in methylation conjugation is S-adenosylmethionine (SAM). SAM is the second most widely used enzyme substrate after ATP and is involved in a wide range of important biological processes. SAM is sythesized from methionine's reaction with ATP, catalyzed by methionine adenosyltransferase (MAT). There are two genes, MAT1A and MAT2A, which encode for two homologous MAT catalytic subunits, 1 and 2. During conjugation with nucleophilic substrates, the methyl group attached to the sulfonium ion of SAM is transferred to the substrate forming the conjugate. SAM, having lost the methyl moiety, is converted to S-adenosylhomocysteine (SAH). SAH can be hydrolyzed to form adenosine and homocysteine. Homocysteine can either be converted to glutathione or methylated to form methionine, thus forming the starting point for SAM synthesis and completing the cycle. Fuctional groups attacked are phenols, catechols, aliphatic and aromatic amines and sulfhydryl-containing groups. The enzymes that catalyze the transfer of the methyl group to these functional groups are the methyltransferases (MT). MTs are small, cytosolic, monomeric enzymes that utilize SAM as a methyl donor. There are many MTs but the best studied ones are named on the basis of their prototypical substrates: COMT (catechol O-methyltransferase), TPMT (thiopurine methyltransferase), TMT (thiol methyltransferase), HNMT (histamine N-methyltransferase) and NNMT (nicotinamide N-methyltransferase). An example of each enzyme mentioned is given. In each case, a typical substrate for the enzyme is shown.

Evidence475
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref674
xref: http://identifiers.org/pubmed/11805192
comment: Phase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involved are a set of transferases which perform the transfer of the cofactor group to the substrate. The resultant conjugation results in greatly increasing the excretory potential of compounds. Although most conjugations result in pharmacological inactivation or detoxification, some can result in bioactivation. Most of the phase II enzymes are located in the cytosol except UDP-glucuronosyltransferases (UGT), which are microsomal. Phase II reactions are typically much faster than phase I reactions therefore the rate-limiting step for biotransformation of a compound is usually the phase I reaction. Phase II metabolism can deal with all the products of phase I metabolism, be they reactive (Type I substrate) or unreactive/poorly active (Type II substrate) compounds. With the exception of glutathione, the conjugating species needs to be made chemically reactive after synthesis. The availability of the cofactor in the synthesis may be a rate-limiting factor in some phase II pathways as it may prevent the formation of enough conjugating species to deal with the substrate or it's metabolite. As many substrates and/or their metabolites are chemically reactive, their continued presence may lead to toxicity.

Evidence476
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref668
comment: All organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ingestion but inhalation and transdermal routes are also common. The very nature of many chemicals that make them suitable for uptake by these routes, in other words their lipophilicty (favours fat solubility) is also the main reason organisms have developed mechanisms that convert them to hydrophilic (favours water solubility) compounds which are readily excreted via bile and urine. Otherwise, lipophilic chemicals would accumulate in the body and overwhelm defense mechanisms. This process is called biotransformation and is catalyzed by enzymes mainly in the liver of higher organisms but a number of other organs have considerable ability to process xenobiotica such as kidneys, gut and lungs. As well as xenobiotics, many endogenous compounds are commonly eliminated by this process. This mechanism is of ancient origin and a major factor for its development in animals is plants. Most animals are plant eaters and thus are subject to a huge variety of chemical compounds which plants produce to stop themselves being eaten. This complex set of enzymes have several features which make them ideal for biotransformation; (1) metabolites of the parent chemical are usually made more water soluble so it favours rapid excretion via bile and urine (2) the enzymes possess broad and overlapping specificity to be able to deal with newly exposed chemicals (3) metabolites of the parent generally don't have adverse biological effects. In the real world however, all these criteria have exceptions. Many chemicals are transformed into reactive metabolites. In pharmacology, the metabolites of some parent drugs exert the desired pharmacological effect but in the case of polycyclic aromatic hydrocarbons (PAHs), which can undergo epoxidation, it results in the formation of an electrophile which can …

PLCG1 events in ERBB2 signaling
type: Pathway
data source: Provenance1
pathway component: REACT 114367.8
evidence: Evidence708
xref: UnificationXref4953
xref: UnificationXref4954
pathway order: PathwayStep488
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence473
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3053703
comment: The combination of glutamate, cysteine and ATP is required to form glutathione. The steps involved in the synthesis and recycling of glutathione are outlined (Meister, 1988).

Evidence474
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref674
comment: Glutathione S-Transferases (GSTs; EC 2.5.1.18) are another major set of phase II conjugation enzymes. They can be found in the cytosol as well as being microsomal membrane-bound. Cytosolic GSTs are encoded by at least 5 gene families (alpha, mu, pi, theta and zeta GST) whereas membrane-bound enzymes are encoded by single genes. Soluble GSTs are homo- or hetero-dimeric enzymes (approximately 25KDa subunits) which can act on a wide range of endogenous and exogenous electrophiles. GSTs mediate conjugation using glutathione (GSH), a tripeptide synthesized from its precursor amino acids gamma-glutamate, cysteine and glycine. A generalized reaction is RX + GSH -> HX + GSR Glutathione conjugates are excreted in bile and converted to cysteine and mercapturic acid conjugates in the intestine and kidneys. GSH is the major, low molecular weight, non-protein thiol synthesized de novo in mammalian cells. As well as taking part in conjugation reactions, GSH also has antioxidant ability and can metabolize endogenous and exogenous compounds. The nucleophilic GSH attacks the electrophilic substrate forming a thioether bond between the cysteine residue of GSH and the electrophile. The result is generally a less reactive and more water-soluble conjugate that can be easily excreted. In some cases, GSTs can activate compounds to reactive species such as certain haloalkanes and haloalkenes. Substrates for GSTs include epoxides, alkenes and compounds with electrophilic carbon, sulfur or nitrogen centres. There are two types of conjugation reaction with glutathione: displacement reactions where glutathione displaces an electron-withdrawing group and addition reactions where glutathione is added to activated double bond structures or strained ring systems.

Evidence479
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/20522547
xref: http://identifiers.org/pubmed/20873749
xref: http://identifiers.org/pubmed/22382365
xref: http://identifiers.org/pubmed/22609301
xref: http://identifiers.org/pubmed/20060739
xref: http://identifiers.org/pubmed/19675643
xref: http://identifiers.org/pubmed/19021507
comment: Iron-sulfur (Fe-S) proteins are localized in the cytosol, nucleus, and mitochondria of mammalian cells (reviewed in Stemmler et al. 2010, Rouault 2012, Bandyopadhyay et al. 2008, Lill 2009, Lill et al. 2012). Fe-S protein biogenesis in the mitochondrial matrix involves the iron-sulfur cluster (ISC) assembly machinery. Ferrous iron is transported across the inner mitochondrial membrane into the mitochondrial matrix by Mitoferrin-1 and Mitoferrin-2. (Mitoferrin-1 is enriched in erythroid cells while Mitoferrin-2 is ubiquitous.) Frataxin binds ferrous iron in the mitochondrial matrix. The cysteine desulfurase NFS1 in a subcomplex with ISD11 provides the sulfur by converting cyteine into alanine and forming a persulfide which is used for cluster formation on ISCU, the scaffold protein. Interaction between NFS1 and ISD11 is necessary for desulfurase activity. Frataxin binds to a complex containing NFS1, ISD11, and ISCU and is proposed to function as an iron donor to ISCU or as an allosteric switch that activates sulfur transfer and Fe-S cluster assembly (Tsai and Barondeau 2010). Cluster formation also involves the electron transfer chain ferredoxin reductase and ferredoxin. ISCU initially forms clusters containing 2 iron atoms and 2 sulfur atoms ([2Fe-2S] clusters). They are released by the function of HSP70-HSC20 chaperones and the monothiol glutaredoxin GLRX5 and used for assembly of [2Fe-2S] proteins. Assembly of larger clusters such as [4Fe-4S] clusters may involve the function of ISCA1, ISCA2, and IBA57. The clusters are transferred to apo-enzymes such as the respiratory complexes, aconitase, and lipoate synthase through dedicated targeting factors such as IND1, NFU1, and BOLA3.

PublicationXref192
type: PublicationXref
author: Agarwal, AK
title: Lysophospholipid acyltransferases: 1-acylglycerol-3-phosphate O-acyltransferases (AGPATs) From discovery to disease
source: Curr Op Lipidology
year: 2012

Evidence478
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/22101253
xref: http://identifiers.org/pubmed/20547883
xref: http://identifiers.org/pubmed/7050653
xref: http://identifiers.org/pubmed/10899784
comment: NADPH, ferredoxin reductase (FDXR, Adrenodoxin reductase), and ferredoxins (FDX1, FDX1L) comprise a short electron transport chain that provides electrons for biosynthesis of iron-sulfur clusters and steroid hormones (Sheftel et al. 2010, Shi et al. 2012, reviewed in Grinberg et al. 2000, Lambeth et al. 1982).

Evidence477
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/1567230
comment: Two electrons and one proton are transferred from NADPH to the FAD moiety of ferredoxin reductase. A proton from the medium is also taken up by ferredoxin reductase.

UnificationXref1266
type: UnificationXref
id: REACT_10253
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10253.1

UnificationXref1267
type: UnificationXref
id: 4234652
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234652

http://identifiers.org/pubmed/19531029
type: PublicationXref
id: 19531029
author: Kawamukai, Makoto
db: Pubmed
title: Biosynthesis and bioproduction of coenzyme Q10 by yeasts and other organisms
source: Biotechnol. Appl. Biochem. 53:217-26
year: 2009

O2.-
type: SmallMoleculeReference
name: O2-
name: O2.- [ChEBI:7710]
name: Superoxide anion
xref: UnificationXref4784

UnificationXref1268
type: UnificationXref
id: 4234654
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234654

Mg++
type: SmallMoleculeReference
name: Magnesium [ChEBI:18420]
name: Mg2+
name: Magnesium
xref: UnificationXref220

UnificationXref1269
type: UnificationXref
id: REACT_87749
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87749.9

UnificationXref1262
type: UnificationXref
id: 29460
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29460

UnificationXref1263
type: UnificationXref
id: REACT_4966
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4966.2

UnificationXref1264
type: UnificationXref
id: CHEBI:17813
db: ChEBI

UnificationXref640
type: UnificationXref
id: 4236190
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236190

UnificationXref1265
type: UnificationXref
id: 194644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194644

UnificationXref1272
type: UnificationXref
id: REACT_10980
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10980.2

UnificationXref643
type: UnificationXref
id: 76194
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76194

'NAcGlu [mitochondrial matrix]' positively regulates 'carbamoyl-phosphate synthase (ammonia) activity of Homologues of CPS1 [intracellular]'
type: Modulation
data source: Provenance1
xref: UnificationXref2836
controlled: Catalysis239
control type: ACTIVATION
controller: SmallMolecule502

'Fe2+ [nucleoplasm]' is required for 'damaged DNA binding activity of ALKBH2 [intracellular]'
type: Modulation
data source: Provenance1
xref: UnificationXref4275
controlled: Catalysis326
control type: ACTIVATION
controller: SmallMolecule406

UnificationXref1271
type: UnificationXref
id: 196420
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=196420

UnificationXref644
type: UnificationXref
id: REACT_2732
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2732.2

UnificationXref1270
type: UnificationXref
id: CHEBI:17737
db: ChEBI

'Pi [cytosol]' is required for 'ribose phosphate diphosphokinase activity of phosphoribosyl pyrophosphate synthetase 1 holoenzyme (name copied from entity in Homo sapiens) [intracellular]'
type: Modulation
data source: Provenance1
xref: UnificationXref447
controlled: Catalysis27
control type: ACTIVATION
controller: Phosphate

UnificationXref641
type: UnificationXref
id: REACT_94607
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94607.9

'Mg2+ [cytosol]' is required for 'ribose phosphate diphosphokinase activity of phosphoribosyl pyrophosphate synthetase 1 holoenzyme (name copied from entity in Homo sapiens) [intracellular]'
type: Modulation
data source: Provenance1
xref: UnificationXref450
controlled: Catalysis27
control type: ACTIVATION
controller: Mg++

UnificationXref642
type: UnificationXref
id: CHEBI:15346
db: ChEBI

http://identifiers.org/pubmed/15102545
type: PublicationXref
id: 15102545
author: Lewis, DF
db: Pubmed
title: 57 varieties: the human cytochromes P450
source: Pharmacogenomics 5:305-18
year: 2004

'Fe2+ [nucleoplasm]' is required for 'damaged DNA binding activity of ALKBH3 [intracellular]'
type: Modulation
data source: Provenance1
xref: UnificationXref4290
controlled: Catalysis329
control type: ACTIVATION
controller: SmallMolecule406

UnificationXref647
type: UnificationXref
id: P71558
db: UniProt

'Fe2+ [nucleoplasm]' is required for 'damaged DNA binding activity of ALKBH3 [intracellular]'
type: Modulation
data source: Provenance1
xref: UnificationXref4290
controlled: Catalysis330
control type: ACTIVATION
controller: SmallMolecule406

UnificationXref648
type: UnificationXref
id: 4234046
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234046

'Fe2+ [nucleoplasm]' is required for 'damaged DNA binding activity of ALKBH2 [intracellular]'
type: Modulation
data source: Provenance1
xref: UnificationXref4275
controlled: Catalysis327
control type: ACTIVATION
controller: SmallMolecule406

UnificationXref645
type: UnificationXref
id: 76183
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76183

'Fe2+ [nucleoplasm]' is required for 'damaged DNA binding activity of ALKBH2 [intracellular]'
type: Modulation
data source: Provenance1
xref: UnificationXref4275
controlled: Catalysis328
control type: ACTIVATION
controller: SmallMolecule406

UnificationXref646
type: UnificationXref
id: REACT_2630
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2630.2

UnificationXref649
type: UnificationXref
id: 4234047
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234047

Evidence460
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15044486
comment: UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid. The cytosolic enzyme is active as a hexamer and performs two successive oxidations to convert the 6'-hydroxyl of UDP-glucose to a carboxylate with concurrent reduction of 2 mol of NAD+ to NADH.

Evidence461
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17482904
comment: Glucose 1-phosphate and UTP are the precursors to UDP-glucuronate formation. After oxidation of the resultant complex, UDP-glucuronate is transported to the ER lumen.

Evidence462
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref674
xref: http://identifiers.org/pubmed/10836148
xref: http://identifiers.org/pubmed/14977861
comment: Glucuronidation conjugation utilizes UDP-glucuronosyltransferases (UGTs; EC 2.4.1.17) to catalyze a wide range of diverse endogenous and xenobiotic compounds. Glucuronidation is the major pathway in phase II metabolism and accounts for approximately 35% of drug conjugation. UGTs are microsomal membrane-bound and catalyze the transfer of a glucuronate group of uridine diphosphoglucuronate (UDPGA, a co-substrate) to the functional group of specific substrates. UDPGA is synthesized from glucose-1-phosphate (G1P). G1P is required for glycolysis and is present in high concentrations in the cell, making it is unlikely to be a limiting factor in UDPGA synthesis. UDP is added to G1P to form UDP-glucose which is then dehydrogenated to form UDPGA. The basic reaction is UDP-Glucuronate + acceptor -> UDP + acceptor-beta-D-glucuronide The effect of this conjugation is to confer polarity to the substrate which can then be easily excreted in urine or bile. Functional groups acted on include hydroxyl, carboxylate, amino and sulfate groups. There are 2 families of UGTs, UGT1 and UGT2 which are further sub-divided into 3 subfamilies, UGT1A, UGT2A and UGT2B. There are more than 26 different isozymes in humans, of which 18 are functional proteins. They are composed of 527-530 residues and have a molecular weight of 50-57KDa. The UGT1 family comprises of 9 proteins (UGT1A1, 1A3-1A10) but only 5 have been isolated in humans. Example substrates which are glucuronidated are acetaminophen by UGT1A6 and bilirubin by UGT1A1. Members of the UGT2 subfamily are each encoded by their own genes, in contrast to UGT1As which are encoded at the UGT1 locus. Example substrates are morphine conjugation by UGT2B7 and androgenic steroid conjugation by UGT2B17. Xenobiotics conjugated with glucuronic acid can be substrates for beta-glucuronidase, an enzyme common in gut microflora. This enzyme can release the parent or phase I metabolite which can be reabsorbed. It can then either re-exert it's original eff…

Evidence463
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref674
xref: http://identifiers.org/pubmed/9034160
xref: http://identifiers.org/pubmed/12372849
xref: http://identifiers.org/pubmed/16322073
xref: http://identifiers.org/pubmed/15167709
xref: http://identifiers.org/pubmed/10503886
xref: http://identifiers.org/pubmed/11154739
comment: Two groups of sulfotransferease (SULT) enzymes catalyze the transfer of a sulfate group from 3-phosphoadenosine 5-phosphosulfate (PAPS) to a hydroxyl group on an acceptor molecule, yielding a sulfonated acceptor and 3-phosphoadenosine 5-phosphate (PAP). One is localized to the Golgi apparatus and mediates the sulfonation of proteoglycans. The second, annotated here, is cytosolic and mediates the sulfonation of a diverse array of small molecules, increasing their solubilities in water and modifying their physiological functions. There are probably thirteen or more human cytosolic SULT enzymes; eleven of these have been purified and characterized enzymatically, and are annotated here (Blanchard et al. 2004; Gamage et al. 2005). These enzymes appear to be active as dimers. Their substrate specificities are typically broad, and not related in an obvious way to their structures; indeed, apparently orthologous human and rodent SULT enzymes can have different substrate specificities (Glatt 2000), and none has been exhaustively characterized. The substrates listed in the table and annotated here are a sample of the known ones, chosen to indicate the range of activity of these enzymes and to capture some of their known physiologically important targets. Absence of a small molecule - enzyme pair from the table, however, may only mean that it has not yet been studied.

Evidence464
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/1559981
comment: N-acetylation occurs in two sequential steps via a ping-pong Bi-Bi mechanism. In the first step, the acetyl group from acetyl-CoA is transferred to a conserved cysteine residue (position 68) in the active site of NAT, with consequent release of coenzyme-A. In the second step, the acetyl group is transferred to the acceptor substrate and the enzyme returns to its initial state.

Evidence465
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/1559981
comment: N-acetylation occurs in two sequential steps via a ping-pong Bi-Bi mechanism. In the first step, the acetyl group from acetyl-CoA is transferred to a conserved cysteine residue (position 68) in the active site of NAT, with consequent release of coenzyme-A. In the second step, the acetyl group is transferred to the acceptor substrate and the enzyme returns to its initial state.

Evidence467
type: Evidence
evidence code: inferred from electronic annotation
comment: Typical NAT 2 substrates were chosen as examples. They are paraxanthine, isoniazid and N-hydroxy 4-aminobiphenyl.

Evidence466
type: Evidence
evidence code: inferred from electronic annotation
comment: Typical NAT 1 substrates were chosen as examples. They are sulfanilamide, 4-aminosalicylate, 4-aminobenzoate and N-hydroxy 4-aminobiphenyl.

Evidence469
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8968737
comment: Dihydroxybenzoate is a typical substrate for Catechol O-methyltransferase

Evidence468
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref674
xref: http://identifiers.org/pubmed/1559981
xref: http://identifiers.org/pubmed/2340091
xref: http://identifiers.org/pubmed/12052143
comment: N-acetyltransferases (NATs; EC 2.3.1.5) utilize acetyl Co-A in acetylation conjugation reactions. This is the preferred route of conjugating aromatic amines (R-NH2, converted to aromatic amides R-NH-COCH3) and hydrazines (R-NH-NH2, converted to R-NH-NH-COCH3). Aliphatic amines are not substrates for NAT. The basic reaction is Acetyl-CoA + an arylamine = CoA + an N- acetylarylamine NATs are cytosolic and in humans, 2 isoforms are expressed, NAT1 and NAT2. A third isoform, NATP, is a pseudogene and is not expressed. The NAT2 gene contains mutations that decrease NAT2 activity. This mutations was first seen as slow acetylation compared to the normal, fast acetylation of the antituberculosis drug isoniazid. Incidence of the slow acetylator phenotype is high in Middle Eastern populations (70%), average (50%) in Europeans, Americans and Australians and low in Asians (<25% in Chinese, Japanese and Koreans). N-acetylation and methylation pathways differ from other conjugation pathways in that they mask an amine with a nonionizable group so that the conjugates are less water soluble than the parent compound. However, certain N-acetlylations facilitate urinary excretion. N-acetylation occurs in two sequential steps via a ping-pong Bi-Bi mechanism. In the first step, the acetyl group from acetyl-CoA is transferred to a cysteine residue in NAT, with consequent release of coenzyme-A. In the second step, the acetyl group is released from the acetylated NAT to the substrate, subsequently regenerating the enzyme.

carboxymycobactin [ChEBI:62579]
type: SmallMoleculeReference
name: carboxymycobactin
xref: UnificationXref4869

UnificationXref1279
type: UnificationXref
id: 4236201
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236201

ChEBI:18431 7alpha,26-dihydroxycholesterol
type: SmallMoleculeReference
name: 7alpha,26-dihydroxycholesterol
xref: UnificationXref1432

UnificationXref1277
type: UnificationXref
id: 4234659
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234659

'Fe2+ [nucleoplasm]' is required for 'damaged DNA binding activity of ALKBH3 [intracellular]'
type: Modulation
data source: Provenance1
xref: UnificationXref4290
controlled: Catalysis331
control type: ACTIVATION
controller: SmallMolecule406

UnificationXref1278
type: UnificationXref
id: REACT_90195
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90195.9

UnificationXref1275
type: UnificationXref
id: O69686
db: UniProt

UnificationXref651
type: UnificationXref
id: REACT_145202
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145202.5

MLCL
type: SmallMoleculeReference
name: lysoDPG
name: Monolysocardiolipin
name: monolyso cardiolipin [ChEBI:60430]
name: monolysoDPG
name: monolyso cardiolipin
xref: UnificationXref1536

UnificationXref1276
type: UnificationXref
id: 4234657
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234657

UnificationXref650
type: UnificationXref
id: 4234049
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234049

Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
type: Pathway
data source: Provenance1
pathway component: REACT 134355.5
pathway component: REACT 97448.9
evidence: Evidence677
xref: UnificationXref4478
xref: UnificationXref4477
pathway order: PathwayStep662
pathway order: PathwayStep660
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1273
type: UnificationXref
id: 193384
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193384

UnificationXref1274
type: UnificationXref
id: REACT_11015
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11015.1

UnificationXref4359
type: UnificationXref
id: 4235481
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235481

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P63907
data source: Provenance1
name: P63907
name: Adenosine aminohydrolase
name: Adenosine deaminase
xref: UnificationXref1986
feature: FragmentFeature166
cellular location: GO:0005622
comment: Reactome DB_ID: 4234031
display name: ADA

Evidence498
type: Evidence
evidence code: inferred from electronic annotation
comment: The pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR cancer mutants with the wild-type EGFR protein. Red lines emphasize cancer related events and physical entities, while wild-type entities and events are shaded. Please refer to "Signaling by constitutively active EGFR" and "Signaling by EGFR" for detailed pathway summations.

IMP--aspartate ligase 2
type: Protein
entity reference: UniProt:P65880
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenylosuccinate synthetase (EC 6.3.4.4) (IMP--aspartate ligase) (AdSS) (AMPSase)
name: ADSS(2-456)
name: AMPSase 2
name: Adenylosuccinate synthetase 2
name: adenylosuccinate synthetase
name: P65880
xref: UnificationXref1952
feature: FragmentFeature165
cellular location: GO:0005622
comment: Reactome DB_ID: 4234334
display name: AdSS 2

Evidence497
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16777603
xref: http://identifiers.org/pubmed/20033049
xref: http://identifiers.org/pubmed/19560417
xref: http://identifiers.org/pubmed/17177598
xref: http://identifiers.org/pubmed/11087732
xref: http://identifiers.org/pubmed/18511936
xref: http://identifiers.org/pubmed/14718169
xref: http://identifiers.org/pubmed/17646646
xref: http://identifiers.org/pubmed/16849543
xref: http://identifiers.org/pubmed/17349580
xref: http://identifiers.org/pubmed/16969069
xref: http://identifiers.org/pubmed/15837620
xref: http://identifiers.org/pubmed/15284455
xref: http://identifiers.org/pubmed/12471035
xref: http://identifiers.org/pubmed/15269313
xref: http://identifiers.org/pubmed/17085664
xref: http://identifiers.org/pubmed/16187797
xref: http://identifiers.org/pubmed/16314626
xref: http://identifiers.org/pubmed/16024644
xref: http://identifiers.org/pubmed/15118073
xref: http://identifiers.org/pubmed/17699773
comment: Signaling by EGFR is frequently activated in cancer through either genomic amplification of the EGFR locus, resulting in over-expression of the wild-type protein, or through activating mutations in the coding sequence of the EGFR gene, resulting in expression of a constitutively active mutant protein. Epidermal growth factor receptor kinase domain mutants are present in ~16% of non-small-cell lung cancers (NSCLCs), but are also found in other cancer types, such as breast cancer, colorectal cancer, ovarian cancer and thyroid cancer. EGFR kinase domain mutants harbor activating mutations in exons 18-21 which code for the kinase domain (amino acids 712-979) . Small deletions, insertions or substitutions of amino acids within the kinase domain lock EGFR in its active conformation in which the enzyme can dimerize and undergo autophosphorylation spontaneously, without ligand binding (although ligand binding ability is preserved), and activate downstream signaling pathways that promote cell survival (Greulich et al. 2005, Zhang et al. 2006, Yun et al. 2007, Red Brewer et al. 2009). In glioblastoma, the most prevalent EGFR mutation, present in ~25% of tumors, is the deletion of the ligand binding domain of EGFR, accompanied with amplification of the mutated allele, which results in over-expression of the mutant protein known as EGFRvIII. EGFRvIII mutant is not able to bind a ligand, but dimerizes and autophosphorylates spontaneously and is therefore constitutively active (Fernandes et al. 2001). Point mutations in the extracellular domain of EGFR are also frequently found in glioblastoma. Similar to kinase domain mutations, point mutations in the extracellular domain result in constitutively active EGFR proteins that signal in the absence of ligands, but ligand binding ability and responsiveness are preserved (Lee et al. 2006). Both EGFR kinase domain mutants and EGFRvIII mutant need to maintain association with the chaperone heat shock protein 90 (HSP90) for proper functio…

UnificationXref4357
type: UnificationXref
id: REACT_111412
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111412.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P65880
data source: Provenance1
name: IMP--aspartate ligase 1
name: AMPSase 1
name: Adenylosuccinate synthetase isozyme 1
name: AdSS 1
name: adenylosuccinate synthetase 1
name: P65880
name: adenylosuccinate synthetase like 1
xref: UnificationXref1949
feature: FragmentFeature164
cellular location: GO:0005622
comment: Reactome DB_ID: 4234331
display name: ADSSL1

Evidence496
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9108479
comment: Benzoquinoid ansamycins (geldanamycin, herbimycin, and geldanamycin derivatives 17-AAG, 17-DMAG and IPI-504) are antitumor antibiotics that inactivate HSP90 by binding to its substrate-binding pocket.

UnificationXref4358
type: UnificationXref
id: 4235480
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235480

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A5A1
data source: Provenance1
name: guanine monophosphate synthetase
name: Glutamine amidotransferase
name: P0A5A1
name: GMP synthetase
name: GMP synthase (glutamine-hydrolyzing)
xref: UnificationXref1939
feature: FragmentFeature163
cellular location: GO:0005622
comment: Reactome DB_ID: 4233941
display name: GMPS

Evidence495
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15142631
xref: http://identifiers.org/pubmed/10404636
xref: http://identifiers.org/pubmed/21252999
xref: http://identifiers.org/pubmed/12297041
xref: http://identifiers.org/pubmed/10459005
comment: The epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational change that unmasks the dimerization interface in the extracellular domain of EGFR, leading to receptor homo- or heterodimerization at the cell surface. Dimerization of the extracellular regions of EGFR triggers additional conformational change of the cytoplasmic EGFR regions, enabling the kinase domains of two EGFR molecules to achieve the catalytically active conformation. Ligand activated EGFR dimers trans-autophosphorylate on tyrosine residues in the cytoplasmic tail of the receptor. Phosphorylated tyrosines serve as binding sites for the recruitment of signal transducers and activators of intracellular substrates, which then stimulate intracellular signal transduction cascades that are involved in regulating cellular proliferation, differentiation, and survival. Recruitment of complexes containing GRB2 and SOS1 to phosphorylated EGFR dimers either directly, through phosphotyrosine residues that serve as GRB2 docking sites, or indirectly, through SHC1 recruitment, promotes GDP to GTP exchange on RAS, resulting in the activation of RAF/MAP kinase cascade. Binding of complexes of GRB2 and GAB1 to phosphorylated EGFR dimers leads to formation of the active PI3K complex, conversion of PIP2 into PIP3, and activation of AKT signaling. Phospholipase C-gamma1 (PLCG1) can also be recruited directly, through EGFR phosphotyrosine residues that serve as PLCG1 docking sites, which leads to PLCG1 phosphorylation by EGFR and activation of DAG and IP3 signaling. EGFR signaling is downregulated by the action of ubiquitin ligase CBL. CBL binds directly to the phosphorylated EGFR dimer through the phosphotyrosine Y1045 in the C-tail of EGFR, and after CBL is phosphorylated by EGFR, it becomes active and ubiquitinates phosphorylated EGFR dimers, targeting them for degradation. For a recent r…

UnificationXref4355
type: UnificationXref
id: REACT_111889
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111889.1

Evidence494
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/1501243
comment: Activated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1, i.e. PLCG1) which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 is instrumental in the release of calcium from intracellular stores and DAG is involved in protein kinase C activation.

UnificationXref4356
type: UnificationXref
id: 1454919
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1454919

Evidence493
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16260143
comment: This pathway describes the generation of DAG and IP3 by the PLCgamma-mediated hydrolysis of PIP2 and the subsequent downstream signaling events.

UnificationXref4353
type: UnificationXref
id: CHEBI:25696
db: ChEBI

Evidence492
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10884684
comment: Calmodulin (CaM) is a small acidic protein that contains four EF-hand motifs, each of which can bind a calcium ion, therefore it can bind up to four calcium ions. The protein has two approximately symmetrical domains, separated by a flexible hinge region. Calmodulin is the prototypical example of the EâF-hand family of Ca2+-sensing proteins. Changes in intracellular Ca2+ concentration regulate calmodulin in three distinct ways. First, by directing its subcellular distribution. Second, by promoting association with different target proteins. Third, by directing a variety of conformational states in calmodulin that result in target-specific activation. Calmodulin binds and activates several effector protein (e.g. the CaM-dependent adenylyl cyclases, phosphodiesterases, protein kinases and the protein phosphatase calcineurin).

UnificationXref4354
type: UnificationXref
id: 1454930
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1454930

Evidence491
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15381755
comment: One important physiological role for Calmodulin is the regulation of adenylylcyclases. Four of the nine known adenylylcyclases are calcium sensitive, in particular type 8 (AC8).

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
type: Protein
entity reference: O53823
data source: Provenance1
name: GAR transformylase
name: Trifunctional purine biosynthetic protein adenosine-3 (Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase))
name: O53823
name: Trifunctional purine biosynthetic protein adenosine-3
name: GARS
name: AIRS
name: 5'-phosphoribosylglycinamide transformylase
name: Phosphoribosylamine--glycine ligase
name: Glycinamide ribonucleotide synthetase
name: Note: the coordinates are copied over from Homo sapiens.
name: AIR synthase
name: Phosphoribosylformylglycinamidine cyclo-ligase
name: Phosphoribosylglycinamide formyltransferase
name: Phosphoribosyl-aminoimidazole synthetase
name: GART(2-1010)
name: Phosphoribosylglycinamide synthetase
xref: UnificationXref1879
feature: FragmentFeature158
cellular location: GO:0005622
comment: Reactome DB_ID: 4233967
display name: GART

Evidence490
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16125054
xref: http://identifiers.org/pubmed/15337521
comment: Cyclic adenosine 3',5'-monophosphate (cAMP) induces gene transcription through activation of cAMP-dependent protein kinase (PKA), and subsequent phosphorylation of the transcription factor cAMP response element-binding protein, CREB, at serine-133.

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P65829
data source: Provenance1
name: P65829
name: GPAT
name: Glutamine phosphoribosylpyrophosphate amidotransferase
name: Amidophosphoribosyltransferase precursor (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (GPAT)
name: ATASE
name: Amidophosphoribosyltransferase precursor
name: phosphoribosyl pyrophosphate amidotransferase
name: glutamine phosphoribosylpyrophosphate amidotransferase
name: amidophosphoribosyltransferase
xref: UnificationXref1848
feature: FragmentFeature157
cellular location: GO:0005622
comment: Reactome DB_ID: 4233981
display name: PPAT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P65167
data source: Provenance1
name: IMP (inosine monophosphate) dehydrogenase 1
name: Inosine-5'-monophosphate dehydrogenase 1 (EC 1.1.1.205) (IMP dehydrogenase 1) (IMPDH-I) (IMPD 1)
name: IMP dehydrogenase 1
name: IMPDH-I
name: Inosine-5'-monophosphate dehydrogenase 1
name: IMPD 1
name: P65167
xref: UnificationXref1933
feature: FragmentFeature162
cellular location: GO:0005622
comment: Reactome DB_ID: 4233946
display name: IMPDH1

UnificationXref1280
type: UnificationXref
id: REACT_95230
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95230.9

UnificationXref697
type: UnificationXref
id: CHEBI:15531
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P67541
data source: Provenance1
name: Inosinicase
name: Bifunctional purine biosynthesis protein PURH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP synthetase) (ATIC))
name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
name: P67541
name: IMP cyclohydrolase
name: Bifunctional purine biosynthesis protein PURH
name: IMP synthetase
name: AICAR transformylase
name: Phosphoribosylaminoimidazolecarboxamide formyltransferase
xref: UnificationXref1923
feature: FragmentFeature161
cellular location: GO:0005622
comment: Reactome DB_ID: 4233953
display name: ATIC

UnificationXref1281
type: UnificationXref
id: CHEBI:17500
db: ChEBI

UnificationXref696
type: UnificationXref
id: REACT_158112
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158112.3

ASASE
type: Protein
entity reference: P71832
data source: Provenance1
name: Adenylosuccinase
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenylosuccinate lyase
name: ADSL
name: P71832
xref: UnificationXref1915
feature: FragmentFeature160
cellular location: GO:0005622
comment: Reactome DB_ID: 4233961
display name: ASL

UnificationXref1282
type: UnificationXref
id: 192114
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192114

UnificationXref699
type: UnificationXref
id: REACT_3059
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3059.1

FGAM synthase
type: Protein
entity reference: UniProt:P65902
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: FGAMS
name: Formylglycinamide ribotide synthetase
name: Phosphoribosylformylglycinamidine synthase
name: Formylglycinamide ribotide amidotransferase
name: P65902
name: FGARAT
xref: UnificationXref1897
feature: FragmentFeature159
cellular location: GO:0005622
comment: Reactome DB_ID: 4233972
display name: PFAS

UnificationXref1283
type: UnificationXref
id: REACT_10339
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10339.1

UnificationXref698
type: UnificationXref
id: 29508
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29508

UnificationXref1285
type: UnificationXref
id: 4234569
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234569

UnificationXref1284
type: UnificationXref
id: 4234567
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234567

UnificationXref1287
type: UnificationXref
id: CHEBI:17899
db: ChEBI

http://identifiers.org/pubmed/10798271
type: PublicationXref
id: 10798271
author: Heindl, B
author: Zahler, S
author: Kupatt, C
author: Becker, BF
db: Pubmed
title: Endothelial function and hemostasis
source: Z Kardiol 89:160-7
year: 2000

UnificationXref1286
type: UnificationXref
id: REACT_112443
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112443.8

UnificationXref1289
type: UnificationXref
id: REACT_10931
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10931.1

UnificationXref1288
type: UnificationXref
id: 192136
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192136

UnificationXref4352
type: UnificationXref
id: REACT_115283
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115283.8

UnificationXref4351
type: UnificationXref
id: 4236221
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236221

UnificationXref4350
type: UnificationXref
id: REACT_155116
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155116.3

Evidence499
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/1656221
xref: http://identifiers.org/pubmed/15863030
xref: http://identifiers.org/pubmed/10579907
comment: Phospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 domain) of PLC-gamma and of other signaling molecules (such as GTPase-activating protein and phosphatidylinositol 3-kinase-associated p85) direct their binding toward autophosphorylated tyrosine residues of the FGFR. Recruitment of PLC-gamma results in its phosphorylation and activation by the receptor. Activated PLC-gamma hydrolyzes phosphatidyl inositol[4,5] P2 to form the second messengers diacylglycerol (DAG) and Ins [1,4,5]P3, which stimulate calcium release and activation of calcium/calmodulin dependent kinases.

UnificationXref4368
type: UnificationXref
id: REACT_111643
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111643.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O53446
data source: Provenance1
name: O53446
name: Fumarase
name: fumarate hydratase
name: Fumarate hydratase, mitochondrial
xref: UnificationXref1797
feature: FragmentFeature154
cellular location: GO:0005622
comment: Reactome DB_ID: 4233793
display name: FH

Evidence485
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18479171
comment: Abacavir is a nucleoside analogue reverse transcriptase inhibitor with antiretroviral activity, widely used in combination with other drugs to treat HIV-1 infection (Yuen et al. 2008). Its uptake across the plasma membrane is mediated by organic cation transporters SLC22A1, 2, and 3; the transport proteins ABCB1 and ABCG2 mediate its efflux. Abacavir itself is a prodrug. Activation requires phosphorylation by a cytosolic adenosine phosphotransferase and deamination by ADAL deaminase to yield carbovir monophosphate. Cytosolic nucleotide kinases convert carbovir monophosphate to carbovir triphosphate, the active HIV reverse transcriptase inhibitor. Abacavir can be glucuronidated or oxidized to a 5'-carboxylate; these are the major forms in which it is excreted from the body.

UnificationXref4369
type: UnificationXref
id: 1467459
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1467459

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P30234
data source: Provenance1
name: NAD
name: nicotinamide nucleotide transhydrogenase
name: P30234
xref: UnificationXref1787
feature: FragmentFeature153
cellular location: GO:0005622
comment: Reactome DB_ID: 4235143
display name: NNT

Evidence484
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18479171
comment: Abacavir activation proceeds steps of phosphorylation, deamination to yield carbovir monophosphate, and phosphorylation of the latter compound to yield the triphosphate. In addition, abacavir can be conjugated with glucuronide or oxidized to its 5'-carboxylate derivative, the two major forms in which it is excreted from the body (Yuen et al. 2008).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P64097
data source: Provenance1
name: Electron Transfer Flavoprotein beta subunit
name: P64097
name: ETF-beta
xref: UnificationXref1826
feature: FragmentFeature156
cellular location: GO:0005622
comment: Reactome DB_ID: 4234481
display name: ETFB

Evidence487
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11257218
xref: http://identifiers.org/pubmed/1536007
xref: http://identifiers.org/pubmed/1579437
xref: http://identifiers.org/pubmed/8223461
xref: http://identifiers.org/pubmed/12045100
xref: http://identifiers.org/pubmed/10966477
comment: Studies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyces cerevisiae (budding yeast), is well understood, and has served as a model for studies of DNA replication initiation in multicellular eukaryotes, including humans. In general terms, the first step of initiation is the binding of the replication initiator to the origin of replication. The replicative helicase is then assembled onto the origin, usually by a helicase assembly factor. Either shortly before or shortly after helicase assembly, some local unwinding of the origin of replication occurs in a region rich in adenine and thymine bases (often termed a DNA unwinding element, DUE). The unwound region provides the substrate for primer synthesis and initiation of DNA replication. The best-defined eukaryotic origins are those of S. cerevisiae, which have well-conserved sequence elements for initiator binding, DNA unwinding and binding of accessory proteins. In multicellular eukaryotes, unlike S. cerevisiae, these loci appear not to be defined by the presence of a DNA sequence motif. Indeed, choice of replication origins in a multicellular eukaryote may vary with developmental stage and tissue type. In cell-free models of metazoan DNA replication, such as the one provided by Xenopus egg extracts, there are only limited DNA sequence specificity requirements for replication initiation (Kelly & Brown 2000; Bell & Dutta 2002; Marahrens & Stillman 1992; Cimbora & Groudine 2001; Mahbubani et al 1992, Hyrien & Mechali 1993).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O07406
data source: Provenance1
name: O07406
name: D-2-hydroxyglutarate dehydrogenase
xref: UnificationXref1809
feature: FragmentFeature155
cellular location: GO:0005622
comment: Reactome DB_ID: 4235243
display name: D2HGDH

Evidence486
type: Evidence
evidence code: inferred from electronic annotation
comment: Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether they involve carbohydrate-derived or lipid-derived molecules, and within each group it is useful to distinguish processes that mediate the breakdown and oxidation of these molecules to yield energy from ones that mediate their synthesis and storage as internal energy reserves. Synthetic reactions are conveniently grouped by the chemical nature of the end products, such as nucleotides, amino acids and related molecules, and porphyrins. Detoxification reactions (biological oxidations) are likewise conveniently classified by the chemical nature of the toxin. At the same time, all of these processes are tightly integrated. Intermediates in reactions of energy generation are starting materials for biosyntheses of amino acids and other compounds, broad-specificity oxidoreductase enzymes can be involved in both detoxification reactions and biosyntheses, and hormone-mediated signaling processes function to coordinate the operation of energy-generating and energy-storing reactions and to couple these to other biosynthetic processes.

UnificationXref4364
type: UnificationXref
id: 4235487
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235487

Evidence481
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17437964
xref: http://identifiers.org/pubmed/20103563
xref: http://identifiers.org/pubmed/17709369
comment: Cytosolic levels of abacavir are determined by the balance of its facilitated diffusion into the cell mediated by organic cation transporters SLC22A1, 2, and 3, and its ATP-dependent efflux from cells mediated by ABCG2 and ABCB1 (Klaasen and Aleksunes 2010; Pan et al. 2007; Shaik et al. 2007).

UnificationXref4365
type: UnificationXref
id: REACT_141956
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141956.5

O53275
type: Protein
entity reference: O53275
data source: Provenance1
xref: UnificationXref1828
cellular location: GO:0005622
comment: Reactome DB_ID: 4234478

Evidence480
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17709369
comment: The ABCB1 transporter associated with the plasma membrane mediates the ATP-dependent efflux of a variety of xenobiotic molecules. Its ability to transport abacavir is inferred from studies of the corresponding mouse protein (Shaik et al. 2007).

UnificationXref4366
type: UnificationXref
id: CHEBI:35703
db: ChEBI

Evidence483
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/1383219
comment: Cytosolic PCK1 (phosphoenolpyruvate carboxykinase 1) catalyzes the reaction of carbovir diphosphate and ATP to form carbovir triphosphate and ADP. The activity of human PCK1 and relative inactivity of human nucleoside diphosphate kinase are inferred from the properties of the purified rat and bovine enzymes in vitro (Miller et al. 1992).

UnificationXref4367
type: UnificationXref
id: 1131652
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1131652

Evidence482
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/21755941
comment: Cytosolic ADAL (Adenosine DeAminase-Like) catalyzes the reaction of abacavir monophosphate and water to form carbovir monophosphate and cyclopropylamine. The active form of the enzyme is a protein monomer complexed with a zinc ion (Murakami et al. 2011).

UnificationXref1290
type: UnificationXref
id: CHEBI:28477
db: ChEBI

G alpha (z) signalling events
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction418
evidence: Evidence713
xref: UnificationXref4964
xref: UnificationXref4963
pathway order: PathwayStep729
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

O06428
type: Protein
entity reference: O06428
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Decaprenyl-diphosphate synthase subunit 1 ecNumber2.5.1.91/ecNumber
name: DPS1_HUMAN
xref: UnificationXref1714
feature: FragmentFeature148
cellular location: GO:0005622
comment: Reactome DB_ID: 4235823
display name: PDSS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A638
data source: Provenance1
name: P0A638
name: COQ5_HUMAN
name: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial ecNumber2.1.1.201/ecNumber
xref: UnificationXref1734
feature: FragmentFeature150
cellular location: GO:0005622
comment: Reactome DB_ID: 4235818
display name: COQ5

UnificationXref1293
type: UnificationXref
id: 4234581
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234581

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O05572
data source: Provenance1
name: O05572
name: Decaprenyl-diphosphate synthase subunit 1 ecNumber2.5.1.91/ecNumber
name: DPS1_HUMAN
xref: UnificationXref1715
feature: FragmentFeature149
cellular location: GO:0005622
comment: Reactome DB_ID: 4235826
display name: PDSS1

UnificationXref1294
type: UnificationXref
id: 4234582
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234582

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P65097
data source: Provenance1
name: P65097
name: Isocitrate dehydrogenase 2 (NADP), mitochondrial
xref: UnificationXref1782
feature: FragmentFeature152
cellular location: GO:0005622
comment: Reactome DB_ID: 4235147
display name: IDH2

UnificationXref1291
type: UnificationXref
id: 192195
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192195

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P64207
data source: Provenance1
name: P64207
name: GTP cyclohydrolase 1
name: GCH1_HUMAN
xref: UnificationXref1755
feature: FragmentFeature151
cellular location: GO:0005622
comment: Reactome DB_ID: 4235503
display name: GCH1

UnificationXref1292
type: UnificationXref
id: REACT_10471
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10471.1

UnificationXref1298
type: UnificationXref
id: 192013
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192013

UnificationXref1297
type: UnificationXref
id: CHEBI:18402
db: ChEBI

UnificationXref1296
type: UnificationXref
id: REACT_115001
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115001.8

UnificationXref1295
type: UnificationXref
id: 4234584
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234584

UnificationXref1299
type: UnificationXref
id: REACT_10608
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10608.1

UnificationXref4361
type: UnificationXref
id: 4235483
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235483

http://identifiers.org/pubmed/10851172
type: PublicationXref
id: 10851172
author: Miller, FD
author: Kaplan, DR
db: Pubmed
title: Neurotrophin signal transduction in the nervous system
source: Curr Opin Neurobiol 10:381-91
year: 2000

UnificationXref4360
type: UnificationXref
id: 4235482
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235482

UnificationXref4363
type: UnificationXref
id: 4235485
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235485

UnificationXref4362
type: UnificationXref
id: 4235484
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235484

Evidence488
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16613843
xref: http://identifiers.org/pubmed/10075700
comment: Adenylate cyclase is responsive to calcium and calmodulin and produces cAMP. One important physiological role for Calmodulin is the regulation of adenylylcyclases. Four of the ten known adenylylcyclases are calcium sensitive, in particular type 8 (AC8).

Evidence489
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2165385
comment: A number of inactive tetrameric PKA holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. When cAMP binds to two specific binding sites on the regulatory subunits, these undergo a conformational change that causes the dissociation of a dimer of regulatory subunits bound to four cAMP from two monomeric, catalytically active PKA subunits.

UniProt:O33185
type: ProteinReference
xref: UnificationXref1062
organism: BioSource1

UnificationXref4377
type: UnificationXref
id: 4236222
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236222

http://identifiers.org/pubmed/10989446
type: PublicationXref
id: 10989446
author: Tamaki, N
author: Sakata, SF
author: Matsuda, K
db: Pubmed
title: Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver
source: Methods Enzymol 324:376-89
year: 2000

UnificationXref4378
type: UnificationXref
id: REACT_115378
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115378.8

UnificationXref4375
type: UnificationXref
id: 4235500
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235500

UnificationXref4376
type: UnificationXref
id: REACT_158506
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158506.3

UnificationXref4379
type: UnificationXref
id: CHEBI:29101
db: ChEBI

http://identifiers.org/pubmed/9512886
type: PublicationXref
id: 9512886
author: Ramshaw, JA
author: White, J
author: Birk, DE
author: Werkmeister, JA
db: Pubmed
title: Organization of fibrillar collagen in the human and bovine cornea: collagen types V and III
source: Connect Tissue Res 36:165-74
year: 1997

UnificationXref675
type: UnificationXref
id: O86335
db: UniProt

UnificationXref674
type: UnificationXref
id: 4234093
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234093

UnificationXref677
type: UnificationXref
id: O53579
db: UniProt

UnificationXref676
type: UnificationXref
id: 4234097
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234097

UnificationXref679
type: UnificationXref
id: O07798
db: UniProt

UnificationXref678
type: UnificationXref
id: 4234101
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234101

UnificationXref680
type: UnificationXref
id: 4234105
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234105

UnificationXref681
type: UnificationXref
id: O06585
db: UniProt

UnificationXref682
type: UnificationXref
id: 4234109
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234109

UnificationXref683
type: UnificationXref
id: P96285
db: UniProt

UnificationXref684
type: UnificationXref
id: 4234113
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234113

UnificationXref4370
type: UnificationXref
id: REACT_111877
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111877.1

UnificationXref4374
type: UnificationXref
id: 4235498
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235498

UnificationXref4373
type: UnificationXref
id: 4235497
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235497

UnificationXref4372
type: UnificationXref
id: 4235496
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235496

UnificationXref4371
type: UnificationXref
id: 4235495
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235495

UnificationXref4386
type: UnificationXref
id: 4235065
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235065

UnificationXref4387
type: UnificationXref
id: 4235066
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235066

UnificationXref4388
type: UnificationXref
id: 4235067
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235067

UnificationXref4389
type: UnificationXref
id: 4235068
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235068

UnificationXref688
type: UnificationXref
id: 4234121
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234121

UnificationXref687
type: UnificationXref
id: P96202
db: UniProt

UnificationXref686
type: UnificationXref
id: 4234117
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234117

UnificationXref685
type: UnificationXref
id: O50437
db: UniProt

UnificationXref689
type: UnificationXref
id: P96291
db: UniProt

UnificationXref690
type: UnificationXref
id: 4234125
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234125

UnificationXref691
type: UnificationXref
id: O50436
db: UniProt

UnificationXref694
type: UnificationXref
id: 4234131
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234131

UnificationXref695
type: UnificationXref
id: 4234474
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234474

UnificationXref692
type: UnificationXref
id: 4234129
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234129

UnificationXref693
type: UnificationXref
id: 4234130
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234130

UnificationXref4381
type: UnificationXref
id: REACT_4155
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4155.2

UnificationXref4380
type: UnificationXref
id: 74113
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74113

UnificationXref4383
type: UnificationXref
id: REACT_3923
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3923.2

Lipid digestion, mobilization, and transport
type: Pathway
data source: Provenance1
pathway component: Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
pathway component: Trafficking of dietary sterols
pathway component: REACT 159822.3
pathway component: REACT 129886.5
evidence: Evidence104
xref: UnificationXref641
xref: UnificationXref640
pathway order: PathwayStep94
pathway order: PathwayStep96
pathway order: PathwayStep99
pathway order: PathwayStep101
display name: Lipid and lipoprotein metabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref4382
type: UnificationXref
id: 83910
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83910

UnificationXref4385
type: UnificationXref
id: 4235064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235064

UnificationXref4384
type: UnificationXref
id: P65526
db: UniProt

UnificationXref2305
type: UnificationXref
id: 110711
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110711

UnificationXref3439
type: UnificationXref
id: P0A4Y0
db: UniProt

UnificationXref2304
type: UnificationXref
id: CHEBI:18077
db: ChEBI

UnificationXref2307
type: UnificationXref
id: 110685
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110685

UnificationXref3437
type: UnificationXref
id: 140344
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=140344

UnificationXref2306
type: UnificationXref
id: REACT_2310
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2310.1

UnificationXref3438
type: UnificationXref
id: REACT_2939
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2939.2

UnificationXref2309
type: UnificationXref
id: 482625
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=482625

UnificationXref2308
type: UnificationXref
id: REACT_4768
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4768.1

UnificationXref3431
type: UnificationXref
id: REACT_108166
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108166.9

UnificationXref3432
type: UnificationXref
id: 4236056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236056

UnificationXref3430
type: UnificationXref
id: 4236060
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236060

UnificationXref2301
type: UnificationXref
id: CHEBI:16311
db: ChEBI

UnificationXref3435
type: UnificationXref
id: 30389
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30389

UnificationXref2300
type: UnificationXref
id: REACT_2490
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2490.1

UnificationXref3436
type: UnificationXref
id: REACT_3751
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3751.1

UnificationXref2303
type: UnificationXref
id: REACT_2857
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2857.1

UnificationXref3433
type: UnificationXref
id: REACT_110608
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_110608.9

http://identifiers.org/pubmed/15096040
type: PublicationXref
id: 15096040
author: Christianson, DW
author: Gomez, GA
author: Hammock, BD
author: Morisseau, C
db: Pubmed
title: Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis
source: Biochemistry 43:4716-23
year: 2004

UnificationXref2302
type: UnificationXref
id: 110660
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110660

UnificationXref3434
type: UnificationXref
id: CHEBI:17489
db: ChEBI

UnificationXref4329
type: UnificationXref
id: 4236130
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236130

UnificationXref4328
type: UnificationXref
id: REACT_32896
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32896.10

http://identifiers.org/pubmed/10518211
type: PublicationXref
id: 10518211
author: Tartaglia, LA
author: Patel, S
author: Lodish, HF
author: Watson, N
author: Gimeno, RE
author: Ge, P
author: Kotler, M
author: Raimondi, A
author: Hirsch, DJ
author: Stahl, A
author: Punreddy, S
db: Pubmed
title: Identification of the major intestinal fatty acid transport protein
source: Mol Cell 4:299-308
year: 1999

UnificationXref4323
type: UnificationXref
id: 4230308
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230308

UnificationXref4322
type: UnificationXref
id: REACT_90867
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90867.9

UnificationXref4321
type: UnificationXref
id: 4236102
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236102

UnificationXref4320
type: UnificationXref
id: REACT_85790
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85790.9

UnificationXref4327
type: UnificationXref
id: 4236129
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236129

UnificationXref4326
type: UnificationXref
id: REACT_95309
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95309.9

UnificationXref4325
type: UnificationXref
id: 4234250
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234250

UnificationXref4324
type: UnificationXref
id: 4230309
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230309

alpha-D-Glucose 6-phosphate
type: SmallMolecule
entity reference: CHEBI:17665
data source: Provenance1
xref: UnificationXref161
xref: UnificationXref160
cellular location: GO:0005829
comment: Reactome DB_ID: 30537
display name: G6P

Citrate
type: SmallMolecule
entity reference: CHEBI:30769
data source: Provenance1
xref: UnificationXref190
xref: UnificationXref189
cellular location: GO:0005829
comment: Reactome DB_ID: 76190
display name: CIT

UnificationXref3426
type: UnificationXref
id: 4236357
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236357

D-Fructose 1,6-bisphosphate
type: SmallMolecule
entity reference: CHEBI:16905
data source: Provenance1
xref: UnificationXref175
xref: UnificationXref174
cellular location: GO:0005829
comment: Reactome DB_ID: 30014

UnificationXref3427
type: UnificationXref
id: REACT_133275
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133275.5

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:16761
data source: Provenance1
xref: UnificationXref172
xref: UnificationXref171
cellular location: GO:0005829
comment: Reactome DB_ID: 29370
display name: ADP

UnificationXref3428
type: UnificationXref
id: 4236358
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236358

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15422
data source: Provenance1
xref: UnificationXref169
xref: UnificationXref168
cellular location: GO:0005829
comment: Reactome DB_ID: 113592
display name: ATP

UnificationXref3429
type: UnificationXref
id: REACT_138515
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138515.5

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
entity reference: CHEBI:29052
data source: Provenance1
name: (2R)-2-Hydroxy-3-(phosphonooxy)-propanal
xref: UnificationXref206
xref: UnificationXref205
cellular location: GO:0005829
comment: Reactome DB_ID: 29578
display name: GA3P

Dihydroxyacetone phosphate
type: SmallMolecule
entity reference: Dihydroxyacetone phosphate
data source: Provenance1
name: Glycerone phosphate
xref: UnificationXref203
xref: UnificationXref202
cellular location: GO:0005829
comment: Reactome DB_ID: 75970
display name: DHAP

D-Fructose 2,6-bisphosphate
type: SmallMolecule
entity reference: D-Fructose 2,6-bisphosphate [ChEBI:28602]
data source: Provenance1
xref: UnificationXref198
xref: UnificationXref199
cellular location: GO:0005829
comment: Reactome DB_ID: 30533

5'-Adenylic acid
type: SmallMolecule
entity reference: CHEBI:16027
data source: Provenance1
name: Adenylate
name: Adenosine 5'-phosphate
name: 5'-AMP
name: 5'-Adenosine monophosphate
name: adenosine 5'-monophosphate
name: Adenylic acid
xref: UnificationXref194
xref: UnificationXref195
cellular location: GO:0005829
comment: Reactome DB_ID: 76577
display name: AMP

http://identifiers.org/pubmed/7689884
type: PublicationXref
id: 7689884
author: Kurl, RN
author: Verma, M
db: Pubmed
title: Human lung enolase: cloning and sequencing of cDNA and its inducibility with dexamethasone
source: Biochem Mol Biol Int 30:293-303
year: 1993

UnificationXref3420
type: UnificationXref
id: REACT_123917
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123917.1

(R)-2-Hydroxy-3-(phosphonooxy)-1-monoanhydridewith phosphoric propanoic acid
type: SmallMolecule
entity reference: CHEBI:16001
data source: Provenance1
name: 3-Phospho-D-glyceroyl phosphate
xref: UnificationXref213
xref: UnificationXref214
cellular location: GO:0005829
comment: Reactome DB_ID: 29800
display name: 1,3-Bisphospho-D-glycerate

UnificationXref3421
type: UnificationXref
id: CHEBI:64174
db: ChEBI

UnificationXref3422
type: UnificationXref
id: 2162091
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162091

UnificationXref3423
type: UnificationXref
id: REACT_123712
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123712.1

Succinic semialdehyde
type: SmallMoleculeReference
name: Succinate semialdehyde
name: ChEBI:16265 Succinate semialdehyde
xref: UnificationXref3626

http://identifiers.org/pubmed/12686127
type: PublicationXref
id: 12686127
author: Hillary, RA
author: Pegg, AE
db: Pubmed
title: Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide
source: Biochim Biophys Acta 1647:161-6
year: 2003

UnificationXref3424
type: UnificationXref
id: 4235815
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235815

UDP-N-acetyl-D-glucosamine
type: SmallMoleculeReference
name: UDP-N-acetyl-D-glucosamine [ChEBI:16264]
xref: UnificationXref94

UnificationXref3425
type: UnificationXref
id: REACT_126829
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126829.5

UnificationXref4318
type: UnificationXref
id: REACT_95407
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95407.9

UnificationXref4317
type: UnificationXref
id: 4234042
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234042

UnificationXref4319
type: UnificationXref
id: 4236101
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236101

UnificationXref4310
type: UnificationXref
id: 4236107
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236107

UnificationXref4312
type: UnificationXref
id: 4236108
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236108

UnificationXref4311
type: UnificationXref
id: REACT_87979
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87979.9

UnificationXref4314
type: UnificationXref
id: 4230241
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230241

3-Phospho-D-glycerate
type: SmallMolecule
entity reference: CHEBI:17794
data source: Provenance1
name: D-Glycerate 3-phosphate
xref: UnificationXref216
xref: UnificationXref217
cellular location: GO:0005829
comment: Reactome DB_ID: 29728
display name: 3PG

UnificationXref4313
type: UnificationXref
id: REACT_103570
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103570.9

Mg++
type: SmallMolecule
entity reference: Mg++
data source: Provenance1
name: Magnesium
xref: UnificationXref222
xref: UnificationXref221
cellular location: GO:0005829
comment: Reactome DB_ID: 29926
display name: Mg2+

UnificationXref4316
type: UnificationXref
id: 4234041
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234041

UnificationXref4315
type: UnificationXref
id: 4230240
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230240

UnificationXref4340
type: UnificationXref
id: 4234976
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234976

Pyruvate
type: SmallMolecule
entity reference: Pyruvate
data source: Provenance1
name: Pyruvic acid
name: Pyroracemic acid
name: 2-Oxopropanoate
name: 2-Oxopropanoic acid
xref: UnificationXref250
xref: UnificationXref249
cellular location: GO:0005759
comment: Reactome DB_ID: 113557
display name: PYR

UnificationXref4341
type: UnificationXref
id: 4234977
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234977

Carbon dioxide
type: SmallMolecule
entity reference: CHEBI:16526
data source: Provenance1
xref: UnificationXref247
xref: UnificationXref246
cellular location: GO:0005759
comment: Reactome DB_ID: 29376
display name: CO2

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:16761
data source: Provenance1
xref: UnificationXref255
xref: UnificationXref254
cellular location: GO:0005759
comment: Reactome DB_ID: 113581
display name: ADP

Oxalacetic acid
type: SmallMolecule
entity reference: CHEBI:30744
data source: Provenance1
name: Oxosuccinic acid
name: 2-oxobutanedioic acid
name: Oxaloacetic acid
name: Oxaloacetate
xref: UnificationXref253
xref: UnificationXref252
cellular location: GO:0005759
comment: Reactome DB_ID: 113587
display name: OA

Water
type: SmallMolecule
entity reference: CHEBI:15377
data source: Provenance1
xref: UnificationXref230
xref: UnificationXref231
cellular location: GO:0005829
comment: Reactome DB_ID: 29356
display name: H2O

UnificationXref2327
type: UnificationXref
id: REACT_3368
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3368.2

D-Glycerate 2-phosphate
type: SmallMolecule
entity reference: CHEBI:17835
data source: Provenance1
name: 2-Phospho-D-glycerate
xref: UnificationXref228
xref: UnificationXref227
cellular location: GO:0005829
comment: Reactome DB_ID: 30485
display name: 2PG

UnificationXref2326
type: UnificationXref
id: 110668
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110668

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15422
data source: Provenance1
xref: UnificationXref243
xref: UnificationXref244
cellular location: GO:0005759
comment: Reactome DB_ID: 113593
display name: ATP

UnificationXref2329
type: UnificationXref
id: REACT_3541
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3541.2

UnificationXref3459
type: UnificationXref
id: 4234399
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234399

Phosphoenolpyruvic acid
type: SmallMolecule
entity reference: Phosphoenolpyruvic acid
data source: Provenance1
name: Phosphoenolpyruvate
xref: UnificationXref234
xref: UnificationXref233
cellular location: GO:0005829
comment: Reactome DB_ID: 29492
display name: PEP

UnificationXref2328
type: UnificationXref
id: 110720
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110720

UnificationXref2323
type: UnificationXref
id: REACT_2983
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2983.2

UnificationXref3457
type: UnificationXref
id: 4234397
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234397

UnificationXref2322
type: UnificationXref
id: 110652
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110652

UnificationXref3458
type: UnificationXref
id: 4234398
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234398

2-Methyl-3-oxopropanoate [ChEBI:16256]
type: SmallMoleculeReference
name: 3-Oxo-2-methylpropanoate
name: Methylmalonate semialdehyde
name: 2-Methyl-3-oxopropanoate
xref: UnificationXref2768

UnificationXref2325
type: UnificationXref
id: REACT_4429
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4429.2

UnificationXref3455
type: UnificationXref
id: 4234395
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234395

UnificationXref2324
type: UnificationXref
id: 110680
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110680

UnificationXref3456
type: UnificationXref
id: 4234396
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234396

UnificationXref3453
type: UnificationXref
id: 4234393
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234393

UnificationXref3454
type: UnificationXref
id: 4234394
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234394

UnificationXref2321
type: UnificationXref
id: REACT_5595
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5595.2

UnificationXref3451
type: UnificationXref
id: 4234391
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234391

UnificationXref2320
type: UnificationXref
id: 110732
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110732

UnificationXref3452
type: UnificationXref
id: 4234392
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234392

UnificationXref3450
type: UnificationXref
id: 4234390
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234390

UniProt:P30234
type: ProteinReference
xref: UnificationXref1786
organism: BioSource1

UnificationXref4349
type: UnificationXref
id: 4235491
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235491

UnificationXref4348
type: UnificationXref
id: 4235489
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235489

Phosphate
type: SmallMolecule
entity reference: Phosphate
data source: Provenance1
name: Orthophosphate
xref: UnificationXref257
xref: UnificationXref258
cellular location: GO:0005759
comment: Reactome DB_ID: 113548
display name: Pi

UnificationXref4347
type: UnificationXref
id: 4235488
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235488

Coenzyme R
type: SmallMolecule
entity reference: CHEBI:15956
data source: Provenance1
name: D-Biotin
name: Biotin
name: Vitamin H
xref: UnificationXref263
xref: UnificationXref262
cellular location: GO:0005759
comment: Reactome DB_ID: 29582
display name: Btn

UnificationXref4346
type: UnificationXref
id: REACT_113806
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113806.8

Mn(III)
type: SmallMolecule
entity reference: CHEBI:18291
data source: Provenance1
name: Mn(II)
name: Manganese
xref: UnificationXref266
xref: UnificationXref265
cellular location: GO:0005759
comment: Reactome DB_ID: 113527
display name: Mn2+

UnificationXref4345
type: UnificationXref
id: 4234982
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234982

Metabolism of amino acids and derivatives
type: Pathway
data source: Provenance1
pathway component: REACT 108346.9
pathway component: Glyoxylate metabolism
pathway component: Urea synthesis
pathway component: REACT 159699.3
pathway component: Proline catabolism
pathway component: REACT 29991.10
pathway component: REACT 29834.10
pathway component: REACT 92648.9
pathway component: REACT 118227.7
pathway component: REACT 80079.9
pathway component: Branched-chain amino acid catabolism
evidence: Evidence432
xref: UnificationXref3036
xref: UnificationXref3035
xref: RelationshipXref456
pathway order: PathwayStep397
pathway order: PathwayStep409
pathway order: PathwayStep406
pathway order: PathwayStep412
pathway order: PathwayStep429
pathway order: PathwayStep399
pathway order: PathwayStep416
pathway order: PathwayStep404
pathway order: PathwayStep377
pathway order: PathwayStep391
pathway order: PathwayStep394
display name: Amino acid and derivative metabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref4344
type: UnificationXref
id: 4234980
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234980

UnificationXref4343
type: UnificationXref
id: 4234979
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234979

UnificationXref4342
type: UnificationXref
id: 4234978
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234978

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15996
data source: Provenance1
xref: UnificationXref294
xref: UnificationXref295
cellular location: GO:0005829
comment: Reactome DB_ID: 29438
display name: GTP

proton
type: SmallMolecule
entity reference: CHEBI:15378
data source: Provenance1
xref: UnificationXref286
xref: UnificationXref287
cellular location: GO:0005829
comment: Reactome DB_ID: 70106
display name: H+

UnificationXref4330
type: UnificationXref
id: REACT_108373
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108373.9

NADH
type: SmallMolecule
entity reference: CHEBI:16908
data source: Provenance1
xref: UnificationXref283
xref: UnificationXref284
cellular location: GO:0005829
comment: Reactome DB_ID: 73473

UnificationXref2319
type: UnificationXref
id: REACT_5419
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5419.2

Oxalacetic acid
type: SmallMolecule
entity reference: CHEBI:30744
data source: Provenance1
name: Oxosuccinic acid
name: 2-oxobutanedioic acid
name: Oxaloacetic acid
name: Oxaloacetate
xref: UnificationXref281
xref: UnificationXref280
cellular location: GO:0005829
comment: Reactome DB_ID: 76213
display name: OA

UnificationXref2318
type: UnificationXref
id: 110638
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110638

UnificationXref3448
type: UnificationXref
id: 4234388
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234388

H2O2
type: SmallMoleculeReference
name: Hydrogen peroxide
name: H2O2 [ChEBI:16240]
xref: UnificationXref2404

DPN
type: SmallMolecule
entity reference: CHEBI:15846
data source: Provenance1
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref278
xref: UnificationXref279
cellular location: GO:0005829
comment: Reactome DB_ID: 29360
display name: NAD

UnificationXref2317
type: UnificationXref
id: REACT_144680
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144680.5

UnificationXref3449
type: UnificationXref
id: 4234389
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234389

L-Apple acid
type: SmallMolecule
entity reference: CHEBI:30797
data source: Provenance1
name: (S)-Malate
name: L-Malate
name: L-2-Hydroxybutanedioic acid
name: L-Malic acid
xref: UnificationXref275
xref: UnificationXref276
cellular location: GO:0005829
comment: Reactome DB_ID: 198498
display name: MAL

UnificationXref2316
type: UnificationXref
id: 4235171
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235171

http://identifiers.org/pubmed/7917292
type: PublicationXref
id: 7917292
author: Furness, J
author: Doherty, P
author: Walsh, FS
author: Williams, EJ
db: Pubmed
title: Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin
source: Neuron 13:583-94
year: 1994

Acetyl coenzyme A
type: SmallMolecule
entity reference: CHEBI:15351
data source: Provenance1
name: Acetyl-CoA
xref: UnificationXref273
xref: UnificationXref272
cellular location: GO:0005759
comment: Reactome DB_ID: 113559
display name: Ac-CoA

UnificationXref2315
type: UnificationXref
id: REACT_147686
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147686.5

UnificationXref2314
type: UnificationXref
id: 4235170
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235170

UnificationXref3444
type: UnificationXref
id: 4234384
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234384

UnificationXref2313
type: UnificationXref
id: 4235168
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235168

UnificationXref3445
type: UnificationXref
id: 4234385
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234385

UnificationXref2312
type: UnificationXref
id: 4235167
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235167

UnificationXref3446
type: UnificationXref
id: 4234386
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234386

UnificationXref2311
type: UnificationXref
id: P84284
db: UniProt

UnificationXref3447
type: UnificationXref
id: 4234387
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234387

UnificationXref2310
type: UnificationXref
id: REACT_21786
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21786.1

UnificationXref3440
type: UnificationXref
id: 4234379
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234379

UnificationXref3441
type: UnificationXref
id: P71914
db: UniProt

The activation of arylsulfatases
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction2
evidence: Evidence15
xref: UnificationXref51
xref: UnificationXref50
pathway order: PathwayStep13
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3442
type: UnificationXref
id: 4234382
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234382

UnificationXref3443
type: UnificationXref
id: 4234383
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234383

UnificationXref4339
type: UnificationXref
id: 4234975
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234975

UnificationXref4336
type: UnificationXref
id: REACT_16095
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16095.2

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15996
data source: Provenance1
xref: UnificationXref306
xref: UnificationXref305
cellular location: GO:0005759
comment: Reactome DB_ID: 113573
display name: GTP

UnificationXref4335
type: UnificationXref
id: 382577
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=382577

Guanosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:17552
data source: Provenance1
name: Guanosine diphosphate
xref: UnificationXref308
xref: UnificationXref307
cellular location: GO:0005759
comment: Reactome DB_ID: 113525
display name: GDP

UnificationXref4338
type: UnificationXref
id: REACT_16090
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16090.2

Carbon dioxide
type: SmallMolecule
entity reference: CHEBI:16526
data source: Provenance1
xref: UnificationXref297
xref: UnificationXref296
cellular location: GO:0005829
comment: Reactome DB_ID: 113528
display name: CO2

UnificationXref4337
type: UnificationXref
id: 382571
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=382571

Guanosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:17552
data source: Provenance1
name: Guanosine diphosphate
xref: UnificationXref300
xref: UnificationXref299
cellular location: GO:0005829
comment: Reactome DB_ID: 29420
display name: GDP

UnificationXref4332
type: UnificationXref
id: REACT_98432
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98432.9

UnificationXref4331
type: UnificationXref
id: 4236103
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236103

UnificationXref4334
type: UnificationXref
id: REACT_86513
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86513.9

UnificationXref4333
type: UnificationXref
id: 4236095
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236095

UnificationXref3476
type: UnificationXref
id: 4236146
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236146

UnificationXref3475
type: UnificationXref
id: REACT_95000
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95000.9

UnificationXref3474
type: UnificationXref
id: 4236145
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236145

UnificationXref3473
type: UnificationXref
id: REACT_103354
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103354.9

UnificationXref3479
type: UnificationXref
id: REACT_90816
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90816.9

UnificationXref3478
type: UnificationXref
id: 4236147
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236147

Tolerance by Mtb to nitric oxide produced by macrophages
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction392
pathway component: BiochemicalReaction395
pathway component: BiochemicalReaction393
pathway component: BiochemicalReaction390
pathway component: BiochemicalReaction391
pathway component: BiochemicalReaction389
pathway component: BiochemicalReaction394
pathway component: BiochemicalReaction387
pathway component: BiochemicalReaction388
xref: http://identifiers.org/pubmed/15378046
xref: UnificationXref4753
xref: RelationshipXref644
xref: UnificationXref4752
pathway order: PathwayStep691
pathway order: PathwayStep687
pathway order: PathwayStep693
pathway order: PathwayStep688
pathway order: PathwayStep694
pathway order: PathwayStep689
pathway order: PathwayStep692
pathway order: PathwayStep690
pathway order: PathwayStep695
comment: Edited: Jassal, B, 2011-02-28
comment: Reviewed: Warner, D, 2012-04-30
comment: Reactive nitrogen species (RNS), like reactive oxygen species, have numerous target molecules in the bacterial cell, and Mtb has developed remedies to the most important ones of them. This is a key reason for its ability to stay alive in the hostile environment of the late phagosome within human macrophages. Mtb repairs single-base DNA damage caused by DNA alkylation; it scavenges nitric oxide with large amounts of mycothiol and methionine-rich proteins (the nitroso compounds later being reduced). Nitric oxide and peroxynitrite are also directly reduced by a battery of hemoglobins and peroxiredoxins, supported by a network of thioredoxins and respective NADPH-dependent reductases (Fang. 2004).
comment: Authored: Stephan, R, 2011-01-10
organism: BioSource1

UnificationXref3477
type: UnificationXref
id: REACT_92301
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92301.9

Phosphoenolpyruvic acid
type: SmallMolecule
entity reference: Phosphoenolpyruvic acid
data source: Provenance1
name: Phosphoenolpyruvate
xref: UnificationXref310
xref: UnificationXref309
cellular location: GO:0005759
comment: Reactome DB_ID: 372364
display name: PEP

Cori ester
type: SmallMolecule
entity reference: CHEBI:16077
data source: Provenance1
name: alpha-D-Glucose 1-phosphate
name: D-Glucose alpha-1-phosphate
name: D-Glucose 1-phosphate
xref: UnificationXref326
xref: UnificationXref325
cellular location: GO:0005829
comment: Reactome DB_ID: 29548
display name: Glc1P

D-galactose
type: SmallMolecule
entity reference: CHEBI:17118
data source: Provenance1
xref: UnificationXref361
xref: UnificationXref362
cellular location: GO:0005829
comment: Reactome DB_ID: 29590
display name: Gal

alpha-D-Galactopyranose 1-phosphate
type: SmallMolecule
entity reference: CHEBI:17973
data source: Provenance1
xref: UnificationXref365
xref: UnificationXref364
cellular location: GO:0005829
comment: Reactome DB_ID: 30170
display name: alpha-D-Galactose 1-phosphate

UDPglucose
type: SmallMolecule
entity reference: UDPglucose
data source: Provenance1
name: UDP-D-glucose
name: UDP-glucose
xref: UnificationXref371
xref: UnificationXref372
cellular location: GO:0005829
comment: Reactome DB_ID: 29410
display name: UDP-Glc

UDP-D-galactopyranose
type: SmallMolecule
entity reference: UDP-D-galactose [ChEBI:18307]
data source: Provenance1
name: UDPgalactose
name: UDP-D-galactose
xref: UnificationXref374
xref: UnificationXref373
cellular location: GO:0005829
comment: Reactome DB_ID: 29452
display name: UDP-Gal

http://identifiers.org/pubmed/11313909
type: PublicationXref
id: 11313909
author: Wong, YH
author: Ho, MK
db: Pubmed
title: G(z) signaling: emerging divergence from G(i) signaling
source: Oncogene 20:1615-25
year: 2001

UnificationXref628
type: UnificationXref
id: 163580
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=163580

UnificationXref627
type: UnificationXref
id: GO:0005811
db: GENE ONTOLOGY

NADP+
type: SmallMolecule
entity reference: NADP+
data source: Provenance1
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref387
xref: UnificationXref388
cellular location: GO:0005829
comment: Reactome DB_ID: 29366
display name: TPN

UnificationXref629
type: UnificationXref
id: REACT_5517
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5517.2

NADPH
type: SmallMolecule
entity reference: CHEBI:16474
data source: Provenance1
xref: UnificationXref393
xref: UnificationXref394
cellular location: GO:0005829
comment: Reactome DB_ID: 29364
display name: TPNH

D-Glucono-1,5-lactone 6-phosphate
type: SmallMolecule
entity reference: CHEBI:16938
data source: Provenance1
xref: UnificationXref391
xref: UnificationXref390
cellular location: GO:0005829
comment: Reactome DB_ID: 31467
display name: 6-Phospho-D-glucono-1,5-lactone

D-Ribulose 5-phosphate
type: SmallMolecule
entity reference: CHEBI:17363
data source: Provenance1
xref: UnificationXref414
xref: UnificationXref413
cellular location: GO:0005829
comment: Reactome DB_ID: 29732
display name: RU5P

6-Phospho-D-gluconate
type: SmallMolecule
entity reference: CHEBI:16863
data source: Provenance1
xref: UnificationXref406
xref: UnificationXref407
cellular location: GO:0005829
comment: Reactome DB_ID: 29996
display name: PDG

UnificationXref620
type: UnificationXref
id: 4234854
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234854

UnificationXref622
type: UnificationXref
id: REACT_157095
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157095.3

UnificationXref621
type: UnificationXref
id: 4234856
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234856

UnificationXref624
type: UnificationXref
id: REACT_156300
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156300.3

UnificationXref3471
type: UnificationXref
id: REACT_107461
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107461.9

UnificationXref623
type: UnificationXref
id: 4236225
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236225

UnificationXref3472
type: UnificationXref
id: 4236144
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236144

UnificationXref626
type: UnificationXref
id: REACT_159822
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159822.3

UnificationXref625
type: UnificationXref
id: 4236226
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236226

UnificationXref3470
type: UnificationXref
id: 4234411
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234411

UnificationXref3463
type: UnificationXref
id: 4234403
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234403

UnificationXref3462
type: UnificationXref
id: 4234402
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234402

UnificationXref3465
type: UnificationXref
id: 4234405
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234405

UnificationXref3464
type: UnificationXref
id: 4234404
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234404

UnificationXref3467
type: UnificationXref
id: 4234407
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234407

UnificationXref3466
type: UnificationXref
id: 4234406
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234406

E2F mediated regulation of DNA replication
type: Pathway
data source: Provenance1
pathway component: TemplateReaction1
evidence: Evidence3
xref: UnificationXref17
xref: UnificationXref18
pathway order: PathwayStep1
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

carboxymycobactin (loaded)
type: SmallMoleculeReference
name: carboxymycobactin (loaded) [ChEBI:47333]
xref: UnificationXref4895

UnificationXref3469
type: UnificationXref
id: 4234409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234409

UnificationXref3468
type: UnificationXref
id: 4234408
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234408

2'-deoxyadenosine 5'-triphosphate
type: SmallMolecule
entity reference: 2'-deoxyadenosine 5'-triphosphate
data source: Provenance1
xref: UnificationXref437
xref: UnificationXref436
cellular location: GO:0005829
comment: Reactome DB_ID: 110644
display name: dATP

deoxyadenylic acid
type: SmallMolecule
entity reference: CHEBI:17713
data source: Provenance1
name: 2'-Deoxyadenosine 5'-phosphate
name: Deoxyadenosine monophosphate
name: 2'-deoxyadenosine 5'-monophosphate
xref: UnificationXref439
xref: UnificationXref440
cellular location: GO:0005829
comment: Reactome DB_ID: 109386
display name: dAMP

D-Xylulose 5-phosphate
type: SmallMolecule
entity reference: CHEBI:16332
data source: Provenance1
xref: UnificationXref422
xref: UnificationXref421
cellular location: GO:0005829
comment: Reactome DB_ID: 29790
display name: XY5P

D-ribose 5-phosphate
type: SmallMolecule
entity reference: CHEBI:17797
data source: Provenance1
name: Ribose 5-phosphate
xref: UnificationXref433
xref: UnificationXref434
cellular location: GO:0005829
comment: Reactome DB_ID: 73578
display name: R5P

5-Phosphoribosyl 1-pyrophosphate
type: SmallMolecule
entity reference: CHEBI:17111
data source: Provenance1
name: 5-Phosphoribosyl diphosphate
name: 5-phospho-alpha-D-ribose 1-diphosphate
xref: UnificationXref443
xref: UnificationXref442
cellular location: GO:0005829
comment: Reactome DB_ID: 73566
display name: PRPP

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Provenance1
xref: UnificationXref459
xref: UnificationXref460
cellular location: GO:0005576
comment: Reactome DB_ID: 351626

UnificationXref619
type: UnificationXref
id: 4234853
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234853

Phosphate
type: SmallMolecule
entity reference: Phosphate
data source: Provenance1
name: Orthophosphate
name: Inorganic Phosphate
xref: UnificationXref448
xref: UnificationXref449
cellular location: GO:0005829
comment: Reactome DB_ID: 29372
display name: Pi

UnificationXref618
type: UnificationXref
id: O65934
db: UniProt

UnificationXref617
type: UnificationXref
id: REACT_7089
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7089.1

UnificationXref616
type: UnificationXref
id: 171095
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=171095

Water
type: SmallMolecule
entity reference: CHEBI:15377
data source: Provenance1
xref: UnificationXref479
xref: UnificationXref480
cellular location: GO:0043202
comment: Reactome DB_ID: 1605715
display name: H2O

Heparan sulfate chain(2)
type: SmallMolecule
entity reference: CHEBI:63805
data source: Provenance1
xref: UnificationXref477
xref: UnificationXref478
cellular location: GO:0043202
comment: Reactome DB_ID: 2090072

inorganic sulfate
type: SmallMolecule
entity reference: Sulfate [ChEBI:16189]
data source: Provenance1
name: Sulphate
name: Sulfate
xref: UnificationXref465
xref: UnificationXref464
cellular location: GO:0005829
comment: Reactome DB_ID: 174375
display name: SO4(2-)

inorganic sulfate
type: SmallMolecule
entity reference: Sulfate [ChEBI:16189]
data source: Provenance1
name: Sulphate
xref: UnificationXref462
xref: UnificationXref463
cellular location: GO:0005576
comment: Reactome DB_ID: 427648
display name: SO4(2-)

UnificationXref611
type: UnificationXref
id: 4236220
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236220

UnificationXref610
type: UnificationXref
id: REACT_156250
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156250.3

UnificationXref615
type: UnificationXref
id: REACT_14189
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14189.1

UnificationXref614
type: UnificationXref
id: 216762
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=216762

UnificationXref613
type: UnificationXref
id: GO:0030658
db: GENE ONTOLOGY

UnificationXref3460
type: UnificationXref
id: 4234400
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234400

UnificationXref612
type: UnificationXref
id: REACT_158098
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158098.3

UnificationXref3461
type: UnificationXref
id: 4234401
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234401

UnificationXref3499
type: UnificationXref
id: REACT_117054
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117054.2

UnificationXref3498
type: UnificationXref
id: 1217510
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1217510

UnificationXref3497
type: UnificationXref
id: CHEBI:5674
db: ChEBI

UnificationXref3496
type: UnificationXref
id: REACT_117645
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117645.1

UnificationXref3495
type: UnificationXref
id: 1217505
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1217505

Heparan sulfate chain(3)
type: SmallMolecule
entity reference: CHEBI:63806
data source: Provenance1
xref: UnificationXref482
xref: UnificationXref483
cellular location: GO:0043202
comment: Reactome DB_ID: 2090040

sulfate
type: SmallMolecule
entity reference: Sulfate [ChEBI:16189]
data source: Provenance1
xref: UnificationXref485
xref: UnificationXref484
cellular location: GO:0043202
comment: Reactome DB_ID: 1606845
display name: SO4(2-)

Heparan sulfate chain(7)
type: SmallMolecule
entity reference: CHEBI:63810
data source: Provenance1
xref: UnificationXref491
xref: UnificationXref492
cellular location: GO:0043202
comment: Reactome DB_ID: 2090070

Heparan chain(1)
type: SmallMolecule
entity reference: CHEBI:63811
data source: Provenance1
xref: UnificationXref494
xref: UnificationXref495
cellular location: GO:0043202
comment: Reactome DB_ID: 2090045

http://identifiers.org/pubmed/20385007
type: PublicationXref
id: 20385007
author: Turbeville, Sean
author: Harmatz, Paul
author: Nicely, Helen
author: Valayannopoulos, Vassili
db: Pubmed
title: Mucopolysaccharidosis VI
source: Orphanet J Rare Dis 5:5
year: 2010

UnificationXref4304
type: UnificationXref
id: 4236104
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236104

water
type: SmallMolecule
entity reference: CHEBI:15377
data source: Provenance1
xref: UnificationXref536
xref: UnificationXref537
cellular location: GO:0005576
comment: Reactome DB_ID: 109276
display name: H2O

http://identifiers.org/pubmed/18195088
type: PublicationXref
id: 18195088
author: Broer, Stefan
db: Pubmed
title: Amino acid transport across mammalian intestinal and renal epithelia
source: Physiol Rev 88:249-86
year: 2008

UnificationXref4305
type: UnificationXref
id: REACT_83013
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83013.9

I3P
type: SmallMolecule
entity reference: CHEBI:18169
data source: Provenance1
xref: UnificationXref529
xref: UnificationXref528
cellular location: GO:0005829
comment: Reactome DB_ID: 1629731

UnificationXref609
type: UnificationXref
id: 4234845
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234845

UnificationXref4302
type: UnificationXref
id: 4234043
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234043

long-chain fatty acids
type: SmallMolecule
entity reference: CHEBI:15904
data source: Provenance1
xref: UnificationXref543
xref: UnificationXref542
cellular location: GO:0005576
comment: Reactome DB_ID: 174602
display name: LCFAs

UnificationXref4303
type: UnificationXref
id: REACT_101302
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101302.9

cholesterol esters
type: SmallMolecule
entity reference: cholesterol ester [ChEBI:17002]
data source: Provenance1
xref: UnificationXref540
xref: UnificationXref539
cellular location: GO:0005576
comment: Reactome DB_ID: 171076
display name: CHEST

UnificationXref4300
type: UnificationXref
id: 4230245
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230245

I4P
type: SmallMolecule
entity reference: myo-Inositol 4-phosphate [ChEBI:10602]
data source: Provenance1
xref: UnificationXref508
xref: UnificationXref507
cellular location: GO:0005829
comment: Reactome DB_ID: 1629753

UnificationXref606
type: UnificationXref
id: 4234842
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234842

UnificationXref4301
type: UnificationXref
id: 4230246
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230246

UnificationXref605
type: UnificationXref
id: O50389
db: UniProt

1L-myo-Inositol-1-phosphate
type: SmallMolecule
entity reference: CHEBI:18297
data source: Provenance1
xref: UnificationXref523
xref: UnificationXref524
cellular location: GO:0005829
comment: Reactome DB_ID: 870330
display name: I1P

UnificationXref608
type: UnificationXref
id: 4234843
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234843

Inositol
type: SmallMolecule
entity reference: CHEBI:17268
data source: Provenance1
name: Myo-inositol
xref: UnificationXref511
xref: UnificationXref510
cellular location: GO:0005829
comment: Reactome DB_ID: 426910
display name: Ins

UnificationXref607
type: UnificationXref
id: 4234841
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234841

UnificationXref602
type: UnificationXref
id: REACT_13826
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13826.1

UnificationXref3493
type: UnificationXref
id: REACT_116852
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116852.3

UnificationXref601
type: UnificationXref
id: 265546
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265546

UnificationXref3494
type: UnificationXref
id: CHEBI:5292
db: ChEBI

UnificationXref604
type: UnificationXref
id: REACT_14321
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14321.1

UnificationXref3491
type: UnificationXref
id: CHEBI:65324
db: ChEBI

UnificationXref603
type: UnificationXref
id: 265781
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265781

UnificationXref3492
type: UnificationXref
id: 1217507
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1217507

UnificationXref4308
type: UnificationXref
id: 4236106
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236106

UnificationXref4309
type: UnificationXref
id: REACT_29632
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29632.10

UnificationXref3490
type: UnificationXref
id: REACT_116266
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116266.1

UnificationXref4306
type: UnificationXref
id: 4236105
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236105

UnificationXref600
type: UnificationXref
id: REACT_13962
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13962.1

http://identifiers.org/pubmed/18195086
type: PublicationXref
id: 18195086
author: Ashmore, J
db: Pubmed
title: Cochlear outer hair cell motility
source: Physiol Rev 88:173-210
year: 2008

UnificationXref4307
type: UnificationXref
id: REACT_99095
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99095.9

UnificationXref3489
type: UnificationXref
id: 1217506
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1217506

UnificationXref3488
type: UnificationXref
id: CHEBI:64153
db: ChEBI

UnificationXref3485
type: UnificationXref
id: REACT_114174
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114174.8

UnificationXref3484
type: UnificationXref
id: 4236166
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236166

UnificationXref3487
type: UnificationXref
id: 4235419
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235419

UnificationXref3486
type: UnificationXref
id: 4234792
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234792

http://identifiers.org/pubmed/19116634
type: PublicationXref
id: 19116634
author: Bruckner-Tuderman, L
db: Pubmed
title: Can type VII collagen injections cure dystrophic epidermolysis bullosa?
source: Mol Ther 17:6-7
year: 2009

2'-deoxyadenosine 5'-triphosphate
type: SmallMoleculeReference
name: Deoxyadenosine 5'-triphosphate
name: dATP [ChEBI:16284]
name: dATP
name: Deoxyadenosine triphosphate
xref: UnificationXref435

cholate
type: SmallMolecule
entity reference: CHEBI:16359
data source: Provenance1
xref: UnificationXref554
xref: UnificationXref553
cellular location: GO:0005576
comment: Reactome DB_ID: 192431

Phytanate
type: SmallMoleculeReference
name: Phytanate [ChEBI:8189]
name: Phytanic acid
xref: UnificationXref1084

cholesterol
type: SmallMolecule
entity reference: cholest-5-en-3beta-ol
data source: Provenance1
xref: UnificationXref546
xref: UnificationXref545
cellular location: GO:0005576
comment: Reactome DB_ID: 171149
display name: CHOL

bile salts and acids
type: SmallMolecule
data source: Provenance1
member physical entity: taurochenodeoxycholate
member physical entity: glycochenodeoxycholate
member physical entity: taurocholate
member physical entity: glycocholate
member physical entity: chenodeoxycholate
member physical entity: cholate
xref: UnificationXref571
xref: UnificationXref570
cellular location: GO:0005576
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 192483

http://identifiers.org/pubmed/2188967
type: PublicationXref
id: 2188967
author: Hackert, ML
author: Reed, LJ
db: Pubmed
title: Structure-function relationships in dihydrolipoamide acyltransferases.
source: J Biol Chem 265:8971-4
year: 1990

triacylglycerols
type: SmallMolecule
entity reference: CHEBI:17855
data source: Provenance1
xref: UnificationXref585
xref: UnificationXref586
cellular location: GO:0005576
comment: Reactome DB_ID: 171126
display name: TAGs

glycerol
type: SmallMolecule
entity reference: CHEBI:17754
data source: Provenance1
xref: UnificationXref580
xref: UnificationXref581
cellular location: GO:0005576
comment: Reactome DB_ID: 192438
display name: Glycerol

2-Monoacylglycerol
type: SmallMolecule
entity reference: CHEBI:17389
data source: Provenance1
name: 2-MAG
name: 2-acylglycerols
xref: UnificationXref577
xref: UnificationXref578
cellular location: GO:0005576
comment: Reactome DB_ID: 192457
display name: 2AGs

taurochenodeoxycholate
type: SmallMolecule
entity reference: Taurochenodeoxycholate [ChEBI:9407]
data source: Provenance1
xref: UnificationXref569
xref: UnificationXref568
cellular location: GO:0005576
comment: Reactome DB_ID: 192415

glycochenodeoxycholate
type: SmallMolecule
entity reference: CHEBI:36274
data source: Provenance1
xref: UnificationXref566
xref: UnificationXref565
cellular location: GO:0005576
comment: Reactome DB_ID: 192473

chenodeoxycholate
type: SmallMolecule
entity reference: CHEBI:16755
data source: Provenance1
xref: UnificationXref562
xref: UnificationXref563
cellular location: GO:0005576
comment: Reactome DB_ID: 192442

taurocholate
type: SmallMolecule
entity reference: Taurocholate [ChEBI:9408]
data source: Provenance1
xref: UnificationXref560
xref: UnificationXref559
cellular location: GO:0005576
comment: Reactome DB_ID: 192421

glycocholate
type: SmallMolecule
entity reference: CHEBI:17687
data source: Provenance1
xref: UnificationXref556
xref: UnificationXref557
cellular location: GO:0005576
comment: Reactome DB_ID: 192464

UnificationXref3480
type: UnificationXref
id: 4236154
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236154

UnificationXref3481
type: UnificationXref
id: REACT_114367
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114367.8

UnificationXref3482
type: UnificationXref
id: 4236165
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236165

UnificationXref3483
type: UnificationXref
id: REACT_113151
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113151.8

http://identifiers.org/pubmed/15337521
type: PublicationXref
id: 15337521
author: Moens, U
author: Johannessen, M
author: Delghandi, MP
db: Pubmed
title: What turns CREB on?
source: Cell Signal 16:1211-27
year: 2004

UnificationXref2382
type: UnificationXref
id: 4236089
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236089

UnificationXref2383
type: UnificationXref
id: REACT_107755
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107755.9

UnificationXref2380
type: UnificationXref
id: REACT_159723
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159723.3

UnificationXref2381
type: UnificationXref
id: 4236008
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236008

MT3949
type: ProteinReference
name: ftn
name: UniProt:P96237 bfrB
name: bfrB
name: Rv3841
xref: UnificationXref4930
comment: FUNCTION Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe(2+) ions into Fe(3+) ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex.CATALYTIC ACTIVITY 4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.SUBUNIT Homooligomer of 24 subunits that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be stored.INDUCTION Induced by 1 mM reactive nitrogen intermediate sodium nitroprusside dihydrate (at protein level). Induced by exposure to 50 uM FeCl(3). A possible member of the dormancy regulon. Induced in response to reduced oxygen tension (hypoxia), repressed by carbon monoxide (CO). It is hoped that this regulon will give insight into the latent, or dormant phase of infection.SIMILARITY Belongs to the ferritin family. Prokaryotic subfamily.SIMILARITY Contains 1 ferritin-like diiron domain.
organism: BioSource1

Galactose catabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction27
pathway component: BiochemicalReaction30
pathway component: BiochemicalReaction29
pathway component: BiochemicalReaction28
evidence: Evidence70
xref: UnificationXref385
xref: UnificationXref384
xref: RelationshipXref51
pathway order: PathwayStep66
pathway order: PathwayStep62
pathway order: PathwayStep67
pathway order: PathwayStep65
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2387
type: UnificationXref
id: CHEBI:16858
db: ChEBI

UnificationXref2386
type: UnificationXref
id: REACT_11378
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11378.2

UnificationXref2385
type: UnificationXref
id: 196834
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=196834

UnificationXref2384
type: UnificationXref
id: CHEBI:15769
db: ChEBI

Synthesis of Leukotrienes (LT) and Eoxins (EX)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction140
evidence: Evidence245
xref: UnificationXref1615
xref: UnificationXref1616
xref: RelationshipXref216
pathway order: PathwayStep242
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2389
type: UnificationXref
id: REACT_11300
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11300.2

UnificationXref2388
type: UnificationXref
id: 196767
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=196767

UnificationXref2370
type: UnificationXref
id: CHEBI:28806
db: ChEBI

UnificationXref2371
type: UnificationXref
id: 109330
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109330

UnificationXref2372
type: UnificationXref
id: REACT_2753
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2753.2

http://identifiers.org/pubmed/11237722
type: PublicationXref
id: 11237722
author: Ofman, R
author: Lajmir, S
author: Wanders, RJ
db: Pubmed
title: Etherphospholipid biosynthesis and dihydroxyactetone-phosphate acyltransferase: resolution of the genomic organization of the human gnpat gene and its use in the identification of novel mutations
source: Biochem Biophys Res Commun 281:754-60
year: 2001

fgd
type: ProteinReference
name: UniProt:P96253 fgd1
name: Rv0407
name: MT0420
name: fgd1
xref: UnificationXref4862
comment: FUNCTION Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Is essential for the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to an accessory protein (Rv3547), which in turn activates PA-824. Also probably has a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria.CATALYTIC ACTIVITY D-glucose 6-phosphate + oxidized coenzyme F420 = D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420.ENZYME REGULATION Inhibited by citrate.SUBUNIT Homodimer.DISRUPTION PHENOTYPE Cells lacking this gene display a strong resistance to PA-824 and CGI-17341 (nitroimidazo-oxazole).SIMILARITY Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family.
organism: BioSource1

UnificationXref2374
type: UnificationXref
id: REACT_159575
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159575.3

UnificationXref2373
type: UnificationXref
id: 4236010
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236010

UnificationXref2376
type: UnificationXref
id: CHEBI:10049
db: ChEBI

UnificationXref2375
type: UnificationXref
id: 4236011
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236011

UnificationXref2378
type: UnificationXref
id: REACT_150529
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150529.1

UnificationXref2377
type: UnificationXref
id: 2509848
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2509848

UnificationXref2379
type: UnificationXref
id: 4236007
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236007

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P63907
data source: Provenance1
name: P63907
name: Adenosine deaminase-like protein
xref: UnificationXref1997
feature: FragmentFeature167
cellular location: GO:0005622
comment: Reactome DB_ID: 4235796
display name: ADAL

P0A538
type: Protein
entity reference: P0A538
data source: Provenance1
xref: UnificationXref2021
cellular location: GO:0005622
comment: Reactome DB_ID: 4234036

Adenine phosphoribosyltransferase
type: Protein
entity reference: Q50637
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q50637
xref: UnificationXref2034
feature: FragmentFeature168
cellular location: GO:0005622
comment: Reactome DB_ID: 4234019
display name: APRT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A5T0
data source: Provenance1
name: HGPRTase
name: Hypoxanthine-guanine phosphoribosyltransferase
name: P0A5T0
name: HGPRT
xref: UnificationXref2043
feature: FragmentFeature169
cellular location: GO:0005622
comment: Reactome DB_ID: 4234025
display name: HPRT1

http://identifiers.org/pubmed/6928646
type: PublicationXref
id: 6928646
author: Tanaka, K
author: Rhead, WJ
db: Pubmed
title: Demonstration of a specific mitochondrial isovaleryl-CoA dehydrogenase deficiency in fibroblasts from patients with isovaleric acidemia.
source: Proc Natl Acad Sci U S A 77:580-3
year: 1980

UnificationXref2391
type: UnificationXref
id: REACT_3399
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3399.2

UnificationXref2392
type: UnificationXref
id: P67733
db: UniProt

UnificationXref2393
type: UnificationXref
id: 4234662
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234662

UnificationXref2394
type: UnificationXref
id: 4234663
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234663

UnificationXref2390
type: UnificationXref
id: 73524
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73524

Homologues of CAD
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P71811
xref: UnificationXref2083
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4233893

Dihydroorotate oxidase
type: Protein
entity reference: UniProt:P65908
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P65908
name: Dihydroorotate dehydrogenase, mitochondrial precursor
name: DHOdehase
name: dihydroorotate dehydrogenase
name: Dihydroorotate dehydrogenase, mitochondrial precursor (EC 1.3.3.1) (Dihydroorotate oxidase) (DHOdehase) (Fragment)
xref: UnificationXref2107
feature: FragmentFeature176
cellular location: GO:0005622
comment: Reactome DB_ID: 4233887
display name: DHODH

http://identifiers.org/pubmed/12207025
type: PublicationXref
id: 12207025
author: Grodsky, NB
author: Bahnson, BJ
author: Colman, RF
author: Ceccarelli, C
author: Ariyaratne, N
db: Pubmed
title: Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism
source: J Biol Chem 277:43454-62
year: 2002

P0A5U0
type: Protein
entity reference: P0A5U0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Orotate phosphoribosyltransferase
name: UMPS(2-480)
name: OMPdecase
name: OPRtase
name: UMP synthase
name: uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)
name: Uridine 5'-monophosphate synthase
name: Uridine 5'-monophosphate synthase (UMP synthase) (Includes: Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRtase); Orotidine 5'- phosphate decarboxylase (EC 4.1.1.23) (OMPdecase))
name: Orotidine 5'- phosphate decarboxylase
xref: UnificationXref2118
feature: FragmentFeature177
cellular location: GO:0005622
comment: Reactome DB_ID: 4233879
display name: UMPS

P71811
type: Protein
entity reference: P71811
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Aspartate carbamoyltransferase
name: Dihydroorotase
name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
name: CAD protein (Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3))
name: Glutamine-dependent carbamoyl-phosphate synthase
xref: UnificationXref2080
feature: FragmentFeature174
cellular location: GO:0005622
comment: Reactome DB_ID: 4233891
display name: CAD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P57689
data source: Provenance1
name: P57689
name: Aspartate carbamoyltransferase
name: Dihydroorotase
name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
name: CAD protein (Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3))
name: Glutamine-dependent carbamoyl-phosphate synthase
xref: UnificationXref2082
feature: FragmentFeature175
cellular location: GO:0005622
comment: Reactome DB_ID: 4233892
display name: CAD

Homologues of GMPR2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P65172
xref: UnificationXref2058
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4235199

P65172
type: Protein
entity reference: UniProt:P65172
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: GMP reductase 1
xref: UnificationXref2053
feature: FragmentFeature171
cellular location: GO:0005622
comment: Reactome DB_ID: 4235194
display name: GMPR

http://identifiers.org/pubmed/3316206
type: PublicationXref
id: 3316206
author: Kadler, KE
author: Prockop, DJ
author: Hojima, Y
db: Pubmed
title: Assembly of collagen fibrils de novo by cleavage of the type I pC-collagen with procollagen C-proteinase. Assay of critical concentration demonstrates that collagen self-assembly is a classical example of an entropy-driven process
source: J Biol Chem 262:15696-701
year: 1987

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P65170
data source: Provenance1
name: GMP reductase 1
name: P65170
xref: UnificationXref2051
feature: FragmentFeature170
cellular location: GO:0005622
comment: Reactome DB_ID: 4235191
display name: GMPR

Homologues of GMPR
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P65172
xref: UnificationXref2054
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4235195

P65172
type: Protein
entity reference: UniProt:P65172
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: GMP reductase 2
xref: UnificationXref2057
feature: FragmentFeature173
cellular location: GO:0005622
comment: Reactome DB_ID: 4235198
display name: GMPR2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P65170
data source: Provenance1
name: GMP reductase 2
name: P65170
xref: UnificationXref2056
feature: FragmentFeature172
cellular location: GO:0005622
comment: Reactome DB_ID: 4235197
display name: GMPR2

UnificationXref2399
type: UnificationXref
id: 4236213
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236213

UnificationXref2396
type: UnificationXref
id: REACT_32112
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32112.10

UnificationXref2395
type: UnificationXref
id: 4234665
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234665

UnificationXref2398
type: UnificationXref
id: REACT_31159
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31159.10

UnificationXref2397
type: UnificationXref
id: 4236212
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236212

Paraxanthine
type: SmallMoleculeReference
name: Paraxanthine [ChEBI:25858]
xref: UnificationXref3295

UnificationXref2342
type: UnificationXref
id: 110669
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110669

FAD [ChEBI:16238]
type: SmallMoleculeReference
name: FAD
name: Flavin adenine dinucleotide
xref: UnificationXref761

UnificationXref2343
type: UnificationXref
id: REACT_3930
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3930.1

guanine
type: SmallMoleculeReference
name: guanine [ChEBI:16235]
name: 2-amino-6-hydroxypurine
xref: UnificationXref2009

UnificationXref2340
type: UnificationXref
id: 110681
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110681

UnificationXref2341
type: UnificationXref
id: REACT_3210
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3210.1

UnificationXref2346
type: UnificationXref
id: 110694
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110694

UnificationXref2347
type: UnificationXref
id: REACT_5573
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5573.1

UnificationXref2344
type: UnificationXref
id: 110719
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110719

UnificationXref2345
type: UnificationXref
id: REACT_5560
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5560.1

http://identifiers.org/pubmed/12183068
type: PublicationXref
id: 12183068
author: Oldfield, S
author: Ruddick, J
author: Lightman, S
author: Lowry, C
db: Pubmed
title: ABCG4: a novel human white family ABC-transporter expressed in the brain and eye
source: Biochim Biophys Acta 1591:175-9
year: 2002

Homologues of RRM2
type: Protein
data source: Provenance1
member physical entity: Ribonucleotide reductase small chain
xref: UnificationXref7
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4234354

UnificationXref2348
type: UnificationXref
id: 482807
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=482807

UnificationXref2349
type: UnificationXref
id: REACT_21642
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21642.1

Ribonucleotide reductase small chain
type: Protein
entity reference: Q50549
data source: Provenance1
name: Ribonucleoside-diphosphate reductase M2 chain (EC 1.17.4.1) (Ribonucleotide reductase small chain)
name: Note: the coordinates are copied over from Homo sapiens.
name: Q50549
name: Ribonucleoside-diphosphate reductase M2 chain
name: ribonucleotide reductase M2 polypeptide
xref: UnificationXref6
feature: FragmentFeature2
cellular location: GO:0005622
comment: Reactome DB_ID: 4234353
display name: RRM2

Ribonucleotide reductase small chain
type: Protein
entity reference: Q10840
data source: Provenance1
name: Ribonucleoside-diphosphate reductase M2 chain (EC 1.17.4.1) (Ribonucleotide reductase small chain)
name: Note: the coordinates are copied over from Homo sapiens.
name: Q10840
name: Ribonucleoside-diphosphate reductase M2 chain
name: ribonucleotide reductase M2 polypeptide
xref: UnificationXref4
feature: FragmentFeature1
cellular location: GO:0005622
comment: Reactome DB_ID: 4234350
display name: RRM2

UniProt:P96202
type: ProteinReference
xref: UnificationXref687
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P95096
data source: Provenance1
name: DNA ligase I
name: P95096
name: Polydeoxyribonucleotide synthase (ATP)
xref: UnificationXref26
feature: FragmentFeature4
cellular location: GO:0005622
comment: Reactome DB_ID: 4233557
display name: LIG1

UniProt:P96203
type: ProteinReference
xref: UnificationXref652
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P67044
data source: Provenance1
name: TYMS
name: P67044
name: TSase
name: Thymidylate synthase
xref: UnificationXref9
feature: FragmentFeature3
cellular location: GO:0005622
comment: Reactome DB_ID: 4233910
display name: TS

GFPT1/2
type: Protein
data source: Provenance1
member physical entity: Protein10
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref70
cellular location: GO:0005622
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4235135

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A588
data source: Provenance1
name: Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) 1
name: P0A588
xref: UnificationXref68
feature: FragmentFeature7
cellular location: GO:0005622
comment: Reactome DB_ID: 4235133
display name: GFPT1

SUMF2_HUMAN
type: Protein
entity reference: P95060
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Sulfatase-modifying factor 2
name: P95060
xref: UnificationXref45
feature: FragmentFeature5
cellular location: GO:0005622
comment: Reactome DB_ID: 4235562
display name: SUMF2

UniProt:P96204
type: ProteinReference
xref: UnificationXref673
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P95060
data source: Provenance1
name: SUMF1_HUMAN
name: Sulfatase-modifying factor 1
name: P95060
xref: UnificationXref46
feature: FragmentFeature6
cellular location: GO:0005622
comment: Reactome DB_ID: 4235561
display name: SUMF1

UnificationXref2330
type: UnificationXref
id: 110693
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110693

UnificationXref2331
type: UnificationXref
id: REACT_4471
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4471.2

UnificationXref2332
type: UnificationXref
id: 482803
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=482803

UnificationXref2333
type: UnificationXref
id: REACT_21808
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21808.1

UnificationXref2334
type: UnificationXref
id: 110577
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110577

UnificationXref2335
type: UnificationXref
id: REACT_4926
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4926.1

UnificationXref2336
type: UnificationXref
id: 110731
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110731

UnificationXref2337
type: UnificationXref
id: REACT_4564
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4564.1

Disease
type: Pathway
data source: Provenance1
pathway component: Signaling by EGFR in Cancer
pathway component: REACT 161744.2
pathway component: REACT 137838.5
pathway component: REACT 149040.4
pathway component: REACT 162216.2
evidence: Evidence521
xref: UnificationXref3574
xref: UnificationXref3573
pathway order: PathwayStep497
pathway order: PathwayStep509
pathway order: PathwayStep513
pathway order: PathwayStep493
pathway order: PathwayStep515
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2338
type: UnificationXref
id: 110653
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110653

UnificationXref2339
type: UnificationXref
id: REACT_3618
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3618.1

http://identifiers.org/pubmed/21235449
type: PublicationXref
id: 21235449
author: Wijburg, F A
author: Valstar, M J
author: de Ruijter, J
db: Pubmed
title: Mucopolysaccharidosis type III (Sanfilippo Syndrome): emerging treatment strategies
source: Curr Pharm Biotechnol 12:923-30
year: 2011

http://identifiers.org/pubmed/21235446
type: PublicationXref
id: 21235446
author: Beck, Michael
db: Pubmed
title: Mucopolysaccharidosis Type II (Hunter Syndrome): clinical picture and treatment
source: Curr Pharm Biotechnol 12:861-6
year: 2011

UnificationXref2361
type: UnificationXref
id: P64307
db: UniProt

UnificationXref2360
type: UnificationXref
id: REACT_151581
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151581.1

UniProt:P65097
type: ProteinReference
xref: UnificationXref1230
organism: BioSource1

http://identifiers.org/pubmed/10401004
type: PublicationXref
id: 10401004
author: Mercer, JF
author: Ambrosini, L
db: Pubmed
title: Defective copper-induced trafficking and localization of the Menkes protein in patients with mild and copper-treated classical Menkes disease
source: Hum Mol Genet 8:1547-55
year: 1999

UnificationXref2368
type: UnificationXref
id: 2509835
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2509835

UnificationXref3412
type: UnificationXref
id: REACT_122307
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122307.1

UnificationXref2369
type: UnificationXref
id: REACT_152050
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152050.1

UnificationXref3411
type: UnificationXref
id: 2161175
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161175

UnificationXref2366
type: UnificationXref
id: 4236005
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236005

UnificationXref3414
type: UnificationXref
id: 2161176
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161176

UnificationXref2367
type: UnificationXref
id: CHEBI:28807
db: ChEBI

UnificationXref3413
type: UnificationXref
id: CHEBI:64116
db: ChEBI

http://identifiers.org/pubmed/3053703
type: PublicationXref
id: 3053703
author: Meister, A
db: Pubmed
title: Glutathione metabolism and its selective modification
source: J Biol Chem 263:17205-8
year: 1988

UnificationXref2364
type: UnificationXref
id: 4236004
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236004

UnificationXref2365
type: UnificationXref
id: REACT_152757
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152757.3

UnificationXref2362
type: UnificationXref
id: 4236001
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236001

UnificationXref3410
type: UnificationXref
id: CHEBI:34660
db: ChEBI

UnificationXref2363
type: UnificationXref
id: 4236002
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236002

UnificationXref3419
type: UnificationXref
id: 2162075
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162075

UnificationXref3416
type: UnificationXref
id: 4235800
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235800

UnificationXref3415
type: UnificationXref
id: REACT_124587
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124587.1

UnificationXref3418
type: UnificationXref
id: CHEBI:64172
db: ChEBI

UnificationXref3417
type: UnificationXref
id: REACT_144685
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144685.5

UnificationXref2350
type: UnificationXref
id: 4235172
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235172

http://identifiers.org/pubmed/6408492
type: PublicationXref
id: 6408492
author: O'Carroll, AM
author: Tipton, KF
author: Tobbia, I
author: Fowler, CJ
author: Phillips, JP
db: Pubmed
title: The deamination of dopamine by human brain monoamine oxidase. Specificity for the two enzyme forms in seven brain regions
source: Naunyn Schmiedebergs Arch Pharmacol 322:198-202
year: 1983

http://identifiers.org/pubmed/12809551
type: PublicationXref
id: 12809551
author: Blanchard, JS
author: Zheng, R
author: Steenkamp, DJ
author: Vogt, RN
db: Pubmed
title: The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase
source: Biochem J 374:657-66
year: 2003

UnificationXref2355
type: UnificationXref
id: REACT_142638
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142638.5

UnificationXref3403
type: UnificationXref
id: 4235803
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235803

UnificationXref2356
type: UnificationXref
id: 4236131
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236131

UnificationXref3402
type: UnificationXref
id: 4235494
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235494

UnificationXref2357
type: UnificationXref
id: REACT_89651
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89651.9

UnificationXref3401
type: UnificationXref
id: 4235493
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235493

UnificationXref2358
type: UnificationXref
id: CHEBI:16039
db: ChEBI

UnificationXref3400
type: UnificationXref
id: 4235492
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235492

UnificationXref2351
type: UnificationXref
id: 4235173
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235173

UnificationXref2352
type: UnificationXref
id: 4235175
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235175

UnificationXref2353
type: UnificationXref
id: REACT_133532
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133532.5

UnificationXref2354
type: UnificationXref
id: 4235176
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235176

UnificationXref3409
type: UnificationXref
id: REACT_124629
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124629.1

UnificationXref3408
type: UnificationXref
id: 2161194
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161194

UnificationXref2359
type: UnificationXref
id: 2509836
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2509836

UnificationXref3407
type: UnificationXref
id: CHEBI:64112
db: ChEBI

UnificationXref3406
type: UnificationXref
id: REACT_155222
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155222.3

UnificationXref3405
type: UnificationXref
id: 4236360
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236360

http://identifiers.org/pubmed/7683425
type: PublicationXref
id: 7683425
author: Suster, S
author: Schweinfest, CW
author: Kondoh, N
author: Papas, TS
author: Henderson, KW
db: Pubmed
title: Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas
source: Proc Natl Acad Sci U S A 90:4166-70
year: 1993

UnificationXref3404
type: UnificationXref
id: REACT_154779
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154779.3

UnificationXref2071
type: UnificationXref
id: 4236093
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236093

UnificationXref2070
type: UnificationXref
id: REACT_85047
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85047.9

UnificationXref2075
type: UnificationXref
id: REACT_4357
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4357.1

UnificationXref2074
type: UnificationXref
id: 111627
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111627

http://identifiers.org/pubmed/12815048
type: PublicationXref
id: 12815048
author: Joshi, AK
author: Smith, S
author: Zhang, L
author: Rangan, VS
db: Pubmed
title: Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity
source: J Biol Chem 278:33142-9
year: 2003

UnificationXref2073
type: UnificationXref
id: CHEBI:17544
db: ChEBI

UnificationXref2072
type: UnificationXref
id: REACT_98747
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98747.9

Evidence551
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref857
comment: The human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication among this astronomical number of elements. This communication occurs across synapses, the functional connection between neurons. Synapses can be divided into two general classes: electrical synapses and chemical synapses. Electrical synapses permit direct, passive flow of electrical current from one neuron to another. The current flows through gap junctions, specialized membrane channels that connect the two cells. Chemical synapses enable cell-to-cell communication using neurotransmitter release. Neurotransmitters are chemical agents released by presynaptic neurons that trigger a secondary current flow in postsynaptic neurons by activating specific receptor molecules. Neurotransmitter secretion is triggered by the influx of Ca2+ through voltage-gated channels, which gives rise to a transient increase in Ca2+ concentration within the presynaptic terminal. The rise in Ca2+ concentration causes synaptic vesicles (the presynaptic organelles that store neurotransmitters) to fuse with the presynaptic plasma membrane and release their contents into the space between the pre- and postsynaptic cells.

Evidence550
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref857
comment: Chemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron, muscle cell or glad cell. The pre and the post-synaptic cell are separated by a gap of 20nm called the synaptic cleft. The signals pass in a unidirection from pre-synaptic to post-synaptic. The pre-synaptic neuron communicates via the release of neurotransmitter which bind the receptors on the post-synaptic cell.

Evidence553
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18308196
comment: During steady state conditions, cytoplasmic [Ca2+] is reduced by the accumulation of Ca2+ in intracellular stores and Ca2+ extrusion.

Evidence552
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6218823
xref: http://identifiers.org/pubmed/5961668
xref: http://identifiers.org/pubmed/2844759
xref: http://identifiers.org/pubmed/15709690
comment: The plasma membrane Ca-ATPases 1-4 (ATP2B1-4, PMCAs) are P-type Ca2+-ATPases regulated by calmodulin. The PMCA also counter-transports a proton. PMCA is important for Ca2+ homeostasis and function.

Evidence554
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18308196
xref: http://identifiers.org/pubmed/19422456
comment: Ca2+ homeostasis is controlled by processes that elevate or counter the elevation of cytosolic Ca2+. During steady state conditions, cytoplasmic Ca2+ is reduced by the accumulation of Ca2+ in intracellular stores and by Ca2+ extrusion. The primary intracellular calcium store in platelets is the dense tubular system, the equivalent of the ER system in other cell types. Ca2+ is extruded by Ca2+-ATPases including plasma membrane Ca2+ ATPases (PMCAs) and sarco/endoplasmic reticulum Ca2+ -ATPase isoforms (SERCAs). Activation of non- excitable cells involves the agonist-induced elevation of cytosolic Ca2+, an essential process for platelet activation. It occurs through Ca2+ release from intracellular stores and Ca2+ entry through the plasma membrane. Ca2+ store release involves phospholipase C (PLC)-mediated production of inositol-1,4,5-trisphosphate (IP3), which in turn stimulates IP3 receptor channels to release Ca2+ from intracellular stores. This is followed by Ca2+ entry into the cell through plasma membrane calcium channels, a process referred to as store-operated calcium entry (SOCE). Stromal interaction molecule 1 (STIM1), a Ca2+ sensor molecule in intracellular stores, and the four transmembrane channel protein Orai1 are the key players in platelet SOCE. Other major Ca2+ entry mechanisms are mediated by the direct receptor-operated calcium (ROC) channel, P2X1 and transient receptor potential channels (TRPCs).

http://identifiers.org/pubmed/18461140
type: PublicationXref
id: 18461140
author: Kumar, S
author: Hasnain, SE
author: Ehtesham, NZ
author: Tyagi, AK
author: Rathore, SS
author: Farhana, A
author: Ghosh, PC
db: Pubmed
title: Mechanistic insights into a novel exporter-importer system of Mycobacterium tuberculosis unravel its role in trafficking of iron
source: PLoS One 3:e2087
year: 2008

Evidence555
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10798271
xref: http://identifiers.org/pubmed/16297879
xref: PublicationXref865
comment: Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in character. Under acute vascular trauma, vasoconstrictor mechanisms predominate and the endothelium becomes prothrombotic, procoagulatory and proinflammatory in nature. This is achieved by a reduction of endothelial dilating agents: adenosine, NO and prostacyclin; and by the direct action of ADP, serotonin and thromboxane on vascular smooth muscle cells to elicit their contraction (Becker et al. 2000). Cyclooxygenase-2 (COX-2) and endothelial nitric oxide synthase (eNOS) are primarily expressed in endothelial cells. Both are important regulators of vascular function. Under normal conditions, laminar flow induces vascular endothelial COX-2 expression and synthesis of Prostacyclin (PGI2) which in turn stimulates endothelial Nitric Oxide Synthase (eNOS) activity. PGI2 and NO both oppose platelet activation and aggregation, as does the CD39 ecto-ADPase, which decreases platelet activation and recruitment by metabolizing platelet-released ADP.

Evidence556
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/7295321
xref: http://identifiers.org/pubmed/16116451
xref: http://identifiers.org/pubmed/11470505
xref: http://identifiers.org/pubmed/18096503
comment: Monoacylglycerol lipase (MAGL) is a key enzyme in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol to arachidonate and glycerol. In adipocytes MAGL and hormone-sensitive lipase (LIPE) hydrolyze intracellular triglyceride stores. MAGL may also complement lipoprotein lipase (LPL) in completing hydrolysis of monoglycerides resulting from degradation of lipoprotein triglycerides.

Evidence557
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/7295321
xref: http://identifiers.org/pubmed/11588122
xref: http://identifiers.org/pubmed/3102469
xref: PublicationXref871
xref: http://identifiers.org/pubmed/6788766
comment: Diacylglycerol (DAG) is an important source of arachidonic acid, a signalling molecule and the precursor of the prostaglandins. In human platelet almost all the DAG produced from phosphatidylinositol degradation contains arachidonate (Takamura et al. 1987). DAG is hydrolysed by DAG lipase to 2-arachidonylglycerol (2-AG) which is further hydrolysed by monoacylglycerol lipase. 2-AG is an agonist of cannabinoid receptor 1.

Evidence558
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17157506
xref: http://identifiers.org/pubmed/9601053
comment: Hydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into the cytosol, but as DAG is a hydrophobic lipid it remains within the plasma membrane. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, while DAG activates the conventional and unconventional protein kinase C (PKC) isoforms, facilitating the translocation of PKC from the cytosol to the plasma membrane. The effects of DAG are mimicked by tumor-promoting phorbol esters. DAG is also a precursor for the biosynthesis of prostaglandins, the endocannabinoid 2-arachidonoylglycerol and an activator of a subfamily of TRP-C (Transient Receptor Potential Canonical) cation channels 3, 6, and 7.

UnificationXref1349
type: UnificationXref
id: 193472
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193472

Evidence559
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17059469
xref: http://identifiers.org/pubmed/16543958
xref: http://identifiers.org/pubmed/12411949
xref: http://identifiers.org/pubmed/12681240
xref: http://identifiers.org/pubmed/1672265
xref: http://identifiers.org/pubmed/11511514
xref: http://identifiers.org/pubmed/8704248
xref: http://identifiers.org/pubmed/2018971
comment: Platelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the platelet membrane (Ruggeri 2002). Intracellular signaling reactions then enhance the adhesive and procoagulant properties of tethered platelets or of platelets circulating in the proximity. Once platelets have adhered they degranulate, releasing stored secondary agents such as ADP, ATP, and synthesize thromboxane A2. These amplify the response, activating and recruiting further platelets to the area and promoting platelet aggregation. These amplify the response, activating and recruiting further platelets to the area and promoting platelet aggregation. Adenosine nucleotides signal through P2 purinergic receptors on the platelet membrane. ADP activates P2Y1 and P2Y12, which signal via both the alpha and gamma:beta components of the heterotrimeric G-protein (Hirsch et al. 2001, 2006), while ATP activates the ionotropic P2X1 receptor (Kunapuli et al. 2003). Activation of these receptors initiates a complex signaling cascade that ultimately results in platelet activation, aggregation and thrombus formation (Kahner et al. 2006). Integrin AlphaIIbBeta3 is the most abundant platelet receptor, with 40 000 to 80 000 copies per resting platelet, acting as a major receptor for fibrinogen and other adhesive molecules (Wagner et al. 1996). Activation of AlphaIIbBeta3 enhances adhesion and leads to platelet-platelet interactions, and thus aggregation (Philips et al. 1991). GP VI is the most potent collagen receptor initiating signal generation, an ability derived from its interaction with the FcRI gamma chain. This results in the phosphorylation of the gamma-chain by non-receptor tyrosine kinases of the Src family (1). The phosphotyrosine motif is recognized by the SH2 domains of Syk, a tyrosine kinase. This association activates the Syk enzyme, leading to activation (by tyrosine phospho…

UnificationXref1348
type: UnificationXref
id: CHEBI:28701
db: ChEBI

UnificationXref1347
type: UnificationXref
id: REACT_10890
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10890.1

UnificationXref2078
type: UnificationXref
id: REACT_2904
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2904.2

UnificationXref1346
type: UnificationXref
id: 193403
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193403

UnificationXref2079
type: UnificationXref
id: P71811
db: UniProt

UnificationXref1345
type: UnificationXref
id: CHEBI:28533
db: ChEBI

UnificationXref2076
type: UnificationXref
id: CHEBI:17672
db: ChEBI

UnificationXref1344
type: UnificationXref
id: REACT_78210
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78210.9

UnificationXref2077
type: UnificationXref
id: 111647
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111647

UnificationXref1343
type: UnificationXref
id: 4234592
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234592

UnificationXref1342
type: UnificationXref
id: REACT_10835
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10835.1

UnificationXref1341
type: UnificationXref
id: 192356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192356

UniProt:P71558
type: ProteinReference
xref: UnificationXref647
organism: BioSource1

UnificationXref1340
type: UnificationXref
id: CHEBI:15519
db: ChEBI

UnificationXref2080
type: UnificationXref
id: 4233891
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233891

UnificationXref2082
type: UnificationXref
id: 4233892
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233892

Resolution of D-loop structures
type: Pathway
data source: Provenance1
pathway component: REACT 83013.9
evidence: Evidence644
xref: UnificationXref4306
xref: UnificationXref4307
pathway order: PathwayStep630
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2081
type: UnificationXref
id: P57689
db: UniProt

UnificationXref2084
type: UnificationXref
id: 4233894
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233894

UnificationXref2083
type: UnificationXref
id: 4233893
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233893

UnificationXref2086
type: UnificationXref
id: REACT_135238
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135238.5

UnificationXref2085
type: UnificationXref
id: 4233900
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233900

Evidence542
type: Evidence
evidence code: inferred from electronic annotation
comment: Serotonin is first metabolized to 5-hydroxyindole acetaldehyde by monoamine oxidase. 5-hydroxyindole acetaldehyde is then catalyzed by aldehyde dehydrogenase to form 5-hydroxyindole acetic acid.

Evidence541
type: Evidence
evidence code: inferred from electronic annotation
comment: The human gene SLC6A3 encodes the sodium-dependent dopamine transporter, DAT which mediates the re-uptake of dopamine from the synaptic cleft (Vandenbergh DJ et al, 2000). Dopamine can then be degraded by either COMT or monoamine oxidase.

Evidence540
type: Evidence
evidence code: inferred from electronic annotation
comment: Alternately dopamine is metabolized to homovanillic acid in a two-step reaction in which dopamine is first oxidized to 3,4-dihydroxypheylacetic acid (DOPAC) and then converted to homovanillic acid by catecholamine o-methyltransferase.

Evidence545
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8476432
comment: Ca2+ fluxes through NMDA receptors in the post-synaptic neuron facilitate binding of Ca2+/Calmodulin to adenylate cyclase type 1, 3 or 8, resulting in its activation. Once activated, cAMP is produced which further activates PKA.

Evidence546
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19244110
comment: Ca2+ signal generated through NMDA receptor in the post-synaptic neuron activates adenylate cyclase signal transduction, leading to the activation of PKA and phosphorylation and activation of CREB-induced transcription. The isoforms of adenylate cyclase that are activated by Ca2+ in the brain are I, III and IX.

Evidence543
type: Evidence
evidence code: inferred from electronic annotation
comment: Serotonergic neurotransmission affects a wide range of behaviors, from food intake and reproductive activity, to sensory processing and motor activity, to cognition and emotion. One such key regulator is the serotonin transporter (5-HTT), which is observed to remove serotonin released into the synaptic cleft.

Evidence544
type: Evidence
evidence code: inferred from electronic annotation
comment: Neurotransmitter released in the synaptic cleft binds to specific receptors on the post-synaptic cell and the excess of the neurotransmitter is cleared to prevent over activation of the post-synaptic cell. The neurotransmitter is cleared by either re-uptake by the pre-synaptic neuron, diffusion in the perisynaptic area, uptake by astrocytes surrounding the synaptic cleft or enzymatic degradation of the neurotransmitter. This topic will be annotated in a future release.

UnificationXref1359
type: UnificationXref
id: 159432
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159432

Evidence549
type: Evidence
evidence code: inferred from electronic annotation
comment: The neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein coupled receptors that function to transmit the signals from the post-synaptic membrane to the cell body.

UnificationXref1358
type: UnificationXref
id: REACT_10195
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10195.1

Evidence547
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18616423
comment: Ca2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca2+ within the spine leads to phosphorylation of Cyclic AMP Response Element binding protein (CREB) at serine 133 which is involved in the transcription of genes that results in long lasting changes in the synapse. The phosphorylation of CREB by increased Ca2+ can be brought about by distinct molecular pathways that may involve MAP kinase, activation of adenylate cyclase, activation of CaMKII and/or the activation of CaMKIV.

Evidence548
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18616423
comment: NMDA receptors are a subtype of ionotropic glutamate receptors that are specifically activated by a glutamate agonist N-methyl-D-aspartate (NMDA). Activation of NMDA receptor involves opening of the ion channel that allows the influx of Ca2+. NMDA receptors are central to activity dependent changes in synaptic strength and are predominantly involved in the synaptic plasticity that pertain to learning and memory. A unique feature of NMDA receptor unlike other glutamate receptors is the requirement of dual activation of the NMDA receptor, which require both voltage dependent and ligand dependent activation. At resting membrane potential the NMDA receptors are blocked by Mg2+. The voltage dependent Mg2+ block is relieved upon depolarization of the post-synpatic membrane . The ligand dependent activation of the NMDA receptor requires co-activation by two ligands, namely glutamate and glycine. NMDA receptors are coincidence detector, and are activated only if there is simultaneous activation of both pre and post-synaptic cell. Upon activation NMDA receptors allow the influx of Ca2+ that initiates various molecular signaling cascades that are involved in the process of learning and memory.

UnificationXref2087
type: UnificationXref
id: CHEBI:15859
db: ChEBI

UnificationXref1355
type: UnificationXref
id: 4234632
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234632

UnificationXref2088
type: UnificationXref
id: 111628
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111628

UnificationXref1354
type: UnificationXref
id: REACT_10619
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10619.1

UnificationXref2089
type: UnificationXref
id: REACT_3042
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3042.1

UnificationXref1357
type: UnificationXref
id: 159435
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159435

UnificationXref1356
type: UnificationXref
id: REACT_31738
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31738.10

UnificationXref1351
type: UnificationXref
id: 4234643
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234643

UnificationXref1350
type: UnificationXref
id: REACT_10969
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10969.1

UnificationXref1353
type: UnificationXref
id: 193451
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193451

UnificationXref1352
type: UnificationXref
id: REACT_105774
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105774.9

UnificationXref2053
type: UnificationXref
id: 4235194
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235194

UnificationXref2052
type: UnificationXref
id: P65172
db: UniProt

UnificationXref2051
type: UnificationXref
id: 4235191
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235191

UnificationXref2050
type: UnificationXref
id: P65170
db: UniProt

PublicationXref408
type: PublicationXref
author: Nicholls, DG
author: Ferguson, SJ
title: Bioenergetics 3
source: 89-134
year: 2002

http://identifiers.org/pubmed/3053686
type: PublicationXref
id: 3053686
author: Rozen, R
author: MacKenzie, RE
author: Bell, AW
author: Hum, DW
db: Pubmed
title: Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.
source: J Biol Chem 263:15946-50
year: 1988

PublicationXref409
type: PublicationXref
author: Murray, RK
title: Harper's Biochemistry 25th Edn.
source: 137-48

Evidence531
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19300440
comment: Succinate semialdehyde dehydrogenase (SSADH) converts succinate semialdehyde, in a final step of GABA degradation, into succinate. SSADH uses one water molecule and one molecule of NAD+ per molecule of succinyate semialdehyde.

Evidence530
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/7851425
comment: GABA is converted to succinate semialdehyde by 4-aminobutyrate aminotransferase

http://identifiers.org/pubmed/15130560
type: PublicationXref
id: 15130560
author: Mulliez, E
author: Atta, M
author: Fontecave, M
db: Pubmed
title: S-adenosylmethionine: nothing goes to waste
source: Trends Biochem Sci 29:243-9
year: 2004

http://identifiers.org/pubmed/17237348
type: PublicationXref
id: 17237348
author: Pacher, P
author: Liaudet, L
author: Beckman, JS
db: Pubmed
title: Nitric oxide and peroxynitrite in health and disease
source: Physiol Rev 87:315-424
year: 2007

UnificationXref1328
type: UnificationXref
id: REACT_10934
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10934.1

Evidence536
type: Evidence
evidence code: inferred from electronic annotation
comment: 3-methoxytyramine generated by COMT after methylation of dopamine is oxidized into homovanillic acid by monoamine oxidase A

UnificationXref1327
type: UnificationXref
id: 192316
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192316

Evidence537
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17185601
comment: Dopamine once taken up by the dopamine transporter from the extracellular space into the cytosol is metabolized in a two step reaction to homovanillic acid.The first reaction is catalyzed by catecholamine o-methyl transferase and the subsequent reaction is catalyzed by monoamine oxidase A.

http://identifiers.org/pubmed/19336658
type: PublicationXref
id: 19336658
author: Reue, K
author: Takeuchi, K
db: Pubmed
title: Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
source: Am J Physiol Endocrinol Metab 296:E1195-209
year: 2009

UnificationXref1326
type: UnificationXref
id: CHEBI:37643
db: ChEBI

Evidence538
type: Evidence
evidence code: inferred from electronic annotation
comment: Dopamine is oxidized to 3,4-dihydroxyphenylacetic acid by monoamine oxidase.

http://identifiers.org/pubmed/21310273
type: PublicationXref
id: 21310273
author: Müller, JS
author: Straub, V
author: Schoser, B
author: Abicht, A
author: Hübner, A
author: Krause, S
author: Rodolico, C
author: Mallebrera, CJ
author: Strom, TM
author: Vilchez, JJ
author: Nascimento, A
author: Herrmann, R
author: Colomer, J
author: Bozorgmehr, B
author: Lochmüller, H
author: von der Hagen, M
author: Oldfors, A
author: Guergueltcheva, V
author: Urtizberea, A
author: Voit, T
author: Sieb, JP
author: Nafissi, S
author: Najmabadi, H
author: Palace, J
author: Maxwell, S
author: Diepolder, I
author: Schlotter, B
author: Muelas, N
author: Kariminejad, A
author: Dusl, M
author: Beeson, D
author: Nilipour, Y
author: Lindbergh, C
author: Steinlein, OK
author: Bushby, K
author: Senderek, J
author: Laval, SH
author: Kirschner, J
author: Cossins, J
db: Pubmed
title: Hexosamine biosynthetic pathway mutations cause neuromuscular transmission defect
source: Am J Hum Genet 88:162-72
year: 2011

UnificationXref1325
type: UnificationXref
id: REACT_10443
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10443.1

Evidence539
type: Evidence
evidence code: inferred from electronic annotation
comment: 3,4-dihydroxyphenylacetic acid, generated after oxidation of dopamine by monoamineoxidase, is methylated by catecholamine o-methyltransferase to homovanillic acid.

http://identifiers.org/pubmed/16125054
type: PublicationXref
id: 16125054
author: Moens, U
author: Johannessen, M
author: Delghandi, MP
db: Pubmed
title: The cAMP signalling pathway activates CREB through PKA, p38 and MSK1 in NIH 3T3 cells
source: Cell Signal 17:1343-51
year: 2005

Evidence532
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19172412
comment: GABA is metabolized to succinated by the serial action of two enzymes, 4-aminobutyrate aminotransferase and suucinate semialdehyde dehydrogenase.

Evidence533
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19428801
xref: http://identifiers.org/pubmed/16787421
comment: GABA is a major inhibitory neurotransmitter in the mammalian central nervous system. GABA modulates neuronal excitability throughout the nervous system. Disruption of GABA neurotransmission leads to many neurological diseases including epilepsy and a general anxiety disorder. GABA is synthesized by two distinct enzymes GAD67 and GAD65 that differ in their cellular localization, functional properties and co-factor requirements. GABA synthesized by GAD65 is used for neurotransmission whereas GABA synthesized by GAD67 is used for processes other than neurotransmission such as synaptogenesis and protection against neuronal injury. GABA is loaded into synaptic vesicle with the help of vesicular inhibitory amino acid transporter or VGAT. GAD65 and VGAT are functionally linked at the synaptic vesicle membrane and GABA synthesized by GAD65 is preferentially loaded into the synaptic vesicle over GABA synthesized in cytoplasm by GAD67.The GABA loaded synaptic vesicles are docked at the plasma membrane with the help of the SNARE complexes and primed by interplay between various proteins including Munc18, complexin etc. Release of GABA loaded synaptic vesicle is initiated by the arrival of action potential at the presynaptic bouton and opening of N or P/Q voltage gated Ca2+ channels. Ca2+ influx results in Ca2+ binding by synaptobrevin, which is a part of the SNARE complex that also includes SNAP25 and syntaxin, leading to synaptic vesicle fusion. Release of GABA in the synaptic cleft leads to binding of GABA by the GABA receptors and post ligand binding events.

Evidence534
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17880890
xref: http://identifiers.org/pubmed/16865347
xref: http://identifiers.org/pubmed/16819626
xref: http://identifiers.org/pubmed/15217342
comment: Neurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotransmitter is a multi-step process that is controlled by electrical signals passing through the axons in form of action potential. Neurotransmitters include glutamate, acetylcholine, nor-epinephrine, dopamine and seratonin. Each of the neurotransmitter cycle is independently described.

UnificationXref1329
type: UnificationXref
id: 4234578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234578

Evidence535
type: Evidence
evidence code: inferred from electronic annotation
comment: Dopamine in the cytosol is metabolized to 3-methoxytyramine by catecholamine o-methyltransferase (COMT), which uses s-adenosylmethionine as a methyl group donor.

UniProt:P71538
type: ProteinReference
xref: UnificationXref2454
organism: BioSource1

UnificationXref1320
type: UnificationXref
id: 4234580
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234580

PublicationXref413
type: PublicationXref
author: Metzler, DE
title: Biochemistry - The Chemical Reactions of Living Cells 2nd Edn.
source: 2:1018-84
year: 2003

4-hydroxy-all-trans-retinoic acid
type: SmallMoleculeReference
name: (2E,4E,6E,8E)-9-(3-hydroxy-2,6,6-trimethyl-1-cyclohexenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid
name: 4-hydroxy-(7E,9E,11E,13E)-retinoic acid
name: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-3-hydroxy-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
name: all-trans-4-hydroxyretinoic acid
name: (7E,9E,11E,13E)-4-hydroxyretinoic acid
name: all-trans-4-hydroxyretinoic acid [ChEBI:63795]
xref: UnificationXref3143

UnificationXref2058
type: UnificationXref
id: 4235199
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235199

UnificationXref2059
type: UnificationXref
id: 4235200
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235200

isovanillate
type: SmallMoleculeReference
name: 3-hydroxy-4-methoxybenzoate
name: 3-hydroxy-4-methoxybenzoate [ChEBI:63797]
xref: UnificationXref3318

UnificationXref2056
type: UnificationXref
id: 4235197
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235197

UnificationXref1324
type: UnificationXref
id: 192308
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192308

UnificationXref2057
type: UnificationXref
id: 4235198
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235198

UnificationXref1323
type: UnificationXref
id: REACT_90120
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90120.9

UnificationXref2054
type: UnificationXref
id: 4235195
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235195

PublicationXref412
type: PublicationXref
author: Michal, G
title: Biochemical Pathways - An Atlas of Biochemistry and Molecular Biology
source: 193-200
year: 1999

UnificationXref1322
type: UnificationXref
id: 4234640
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234640

UnificationXref2055
type: UnificationXref
id: 4235196
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235196

PublicationXref411
type: PublicationXref
author: Cox, MM
author: Nelson, DL
title: Lehninger - Principles of Biochemistry 4th Edn.
source: 690-750
year: 2005

UnificationXref1321
type: UnificationXref
id: REACT_86910
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86910.9

UnificationXref2062
type: UnificationXref
id: REACT_130216
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130216.5

UnificationXref2061
type: UnificationXref
id: 4235203
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235203

http://identifiers.org/pubmed/12837131
type: PublicationXref
id: 12837131
author: Ritty, Timothy M
author: Mecham, Robert P
author: Werneck, Claudio C
author: Broekelmann, Thomas J
db: Pubmed
title: Fibrillin-1 and -2 contain heparin-binding sites important for matrix deposition and that support cell attachment
source: Biochem. J. 375:425-32
year: 2003

UnificationXref2064
type: UnificationXref
id: REACT_92683
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92683.9

UnificationXref2063
type: UnificationXref
id: 4236099
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236099

UnificationXref2060
type: UnificationXref
id: 4235201
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4235201

Evidence520
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19935646
xref: http://identifiers.org/pubmed/18772396
comment: Somatic mutations affecting arginine residue 132 of IDH1 (isocitrate dehydrogenase 1, a cytosolic enzyme that normally catalyzes the NADP+-dependent conversion of isocitrate to 2-oxoglutarate), are very commonly found in human glioblastomas (Parsons et al. 2008). These mutant proteins efficiently catalyze the NADPH-dependent reduction of 2-oxoglutarate to form 2-hydroxyglutarate. Cells expressing the mutant protein accumulate elevated levels of 2-hydroxyglutarate, probably in the cytosol as IDH1 is a cytosolic enzyme. The fate of the 2-hydroxyglutarate is unclear, but the high frequency with which the mutation is found in surveys of primary tumors is consistent with the possibility that it is advantageous to the tumor cells (Dang et al 2009).

UnificationXref1337
type: UnificationXref
id: CHEBI:27379
db: ChEBI

Evidence527
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19164095
comment: Eight SLC gene families are involved in the transport of amino acids and oligopeptides.

UnificationXref1336
type: UnificationXref
id: REACT_106343
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106343.9

Evidence528
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8211186
comment: Noradrenaline is degraded by Monoamine oxidase A, which contains FAD as a cofactor. Monoamine oxidase is located in the outer mitochondrial membrane facing the cytoplasmic site. Monoamine xoidase functions as a monomer and is functional both is astrocyes and neurons.

UnificationXref1339
type: UnificationXref
id: REACT_10827
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10827.1

Evidence525
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11591158
comment: SLC7A3 mediates the uptake of cationic amino acids across the plasma membranes of non-epithelial cells (Vekony et al. 2001).

UnificationXref1338
type: UnificationXref
id: 192339
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192339

Evidence526
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18195088
comment: Amino acid transport across plasma membranes is critical to the uptake of these molecules from the gut, to their reabsortion in the kidney proximal tubulues, and to their distribution to cells in which they are required for the synthesis of proteins and of amino acid derived small molecules such as neurotransmitters. Physiological studies have defined 18 "systems" that mediate amino acid transport, each characterized by its amino acid substrates, as well as its pH sensitivity and its association (or not) with ion transport. More recently, molecular cloning studies have allowed the identification of the plasma membrane transport proteins that mediate these reactions. Amino acid uptake mediated by 17 of these transporters is annotated here (Broer 2008).

Evidence523
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18195088
xref: http://identifiers.org/pubmed/9174363
comment: SLC7A2, isoform A, mediates the uptake of cationic amino acids across the plasma membranes of non-epithelial cells (Broer 2008; Closs et al. 1997).

Evidence524
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12202949
xref: http://identifiers.org/pubmed/18195088
xref: http://identifiers.org/pubmed/9174363
comment: SLC7A2, isoform B, mediates the uptake of cationic amino acids across the plasma membranes of non-epithelial cells (Broer 2008; Closs et al. 1997; Furesz et al. 2002).

Evidence521
type: Evidence
evidence code: inferred from electronic annotation
comment: Biological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular viewpoint, human disease pathways have three mechanistic causes: the inclusion of microbially-expressed proteins, altered functions of human proteins, or changed expression levels of otherwise functionally normal human proteins. The first group encompasses the infectious diseases such as influenza, tuberculosis and HIV infection. The second group involves human proteins modified either by a mutation or by an abnormal post-translational event that produces an aberrant protein with a novel function. Examples include somatic mutations of EGFR and FGFR (epidermal and fibroblast growth factor receptor) genes, which encode constitutively active receptors that signal even in the absence of their ligands, or the somatic mutation of IDH1 (isocitrate dehydrogenase 1) that leads to an enzyme active on 2-oxoglutarate rather than isocitrate, or the abnormal protein aggregations of amyloidosis which lead to diseases such as Alzheimer's. Infectious diseases are represented in Reactome as microbial-human protein interactions and the consequent events. The existence of variant proteins and their association with disease-specific biological processes is represented by inclusion of the modified protein in a new or variant reaction, an extension to the 'normal' pathway. Diseases which result from proteins performing their normal functions but at abnormal rates can also be captured, though less directly. Many mutant alleles encode proteins that retain their normal functions but have abnormal stabilities or catalytic efficiencies, leading to normal reactions that proceed to abnormal extents. The phenotypes of such diseases can be revealed when pathway annotations are combined with expression or rate data from other sources.

Evidence522
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12202949
xref: http://identifiers.org/pubmed/10485994
xref: http://identifiers.org/pubmed/18195088
xref: http://identifiers.org/pubmed/9174363
comment: SLC7A1 mediates the uptake of cationic amino acids across the plasma membranes of non-epithelial cells (Broer 2008; Closs et al. 1997; Furesz et al. 2002; Kamath et al. 1999).

UnificationXref2069
type: UnificationXref
id: 4236100
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4236100

UnificationXref1331
type: UnificationXref
id: 193429
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193429

UnificationXref1330
type: UnificationXref
id: REACT_91143
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91143.9

cholesterol ester [ChEBI:17002]
type: SmallMoleculeReference
name: cholesterol ester
name: cholesterol esters
xref: UnificationXref538

UnificationXref2065
type: UnificationXref
id: 4234040
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234040

UnificationXref1333
type: UnificationXref
id: 193442
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193442

UnificationXref2066
type: UnificationXref
id: REACT_93944
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93944.9

UnificationXref1332
type: UnificationXref
id: REACT_10532
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10532.1

UnificationXref2067
type: UnificationXref
id: 4234039
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234039

UnificationXref1335
type: UnificationXref
id: 4234642
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234642

Evidence529
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17891149
xref: http://identifiers.org/pubmed/12519779
xref: http://identifiers.org/pubmed/17478680
comment: Noradrenalin release cycle consists of reacidification of the empty clathrin sculpted monoamine transport vesicle, loading of dopamine into reacidified clathrin coated monamine transport vesicle, conversion of dopamine into Noradrenalin, docking and priming of the noradrenalin synaptic veiscle and then release of noradrenalin synaptic vesicle. In the peripheral nervous system in the peripheral nervous system noradrenalin is stored in large and small dense vesicles and is realesed from large vesicles.

UnificationXref2068
type: UnificationXref
id: REACT_99210
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99210.9

UnificationXref1334
type: UnificationXref
id: REACT_10853
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10853.1

UnificationXref1301
type: UnificationXref
id: 192096
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192096

Evidence519
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19935646
comment: Mutant forms of IDH1 in which the arginine residue at position 132 has been replaced by histidine, cystine, leucine, or serine catalyze the reaction of 2-oxoglutarate and NADPH + H+ to form (R)-2-hydroxyglutarate and NADP+. Like normal IDH1, the mutant enzyme forms a dimer located in the cytosol (Dang et al. 2009). Such mutations occur frequently as a somatic event in human glioblastomas (Parsons et al. 2008). Cells expressing the mutant protein accumulate elevated levels of 2-hydroxyglutarate, probably in the cytosol as IDH1 is a cytosolic enzyme. The fate of the 2-hydroxyglutarate is unclear, but the high frequency with which the mutation is found in surveys of primary tumors is consistent with the possibility that it is advantageous to the tumor cells (Dang et al. 2009).

UnificationXref1302
type: UnificationXref
id: REACT_10579
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10579.1

Evidence518
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18632300
xref: http://identifiers.org/pubmed/16968212
xref: http://identifiers.org/pubmed/20435355
xref: http://identifiers.org/pubmed/21377628
comment: The process of vision involves two stages; the retinoid cycle which supplies and regenerates the visual chromophore required for vision and phototransduction which propagates the light signal. Defects in the genes involved in the retinoid cycle cause degenerative retinal diseases. These defective genes are described here (for reviews see Travis et al. 2007, Palczewski 2010, Fletcher et al. 2011, den Hollander et al. 2008).

Thymidylic acid
type: SmallMoleculeReference
name: Deoxythymidylic acid
name: dTMP
name: Thymidylate
name: 5'-Thymidylic acid
name: Thymidine 5'-phosphate
name: Deoxythymidine 5'-phosphate
name: dTMP [ChEBI:17013]
name: Thymidine monophosphate
xref: UnificationXref2148

UnificationXref1300
type: UnificationXref
id: CHEBI:37642
db: ChEBI

UnificationXref1309
type: UnificationXref
id: REACT_10414
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10414.1

Evidence511
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6467990
xref: http://identifiers.org/pubmed/14091597
xref: PublicationXref806
xref: http://identifiers.org/pubmed/20385007
xref: http://identifiers.org/pubmed/17458871
comment: Mucopolysaccharidosis type VI (MPS VI, Maroteaux-Lamy syndrome, polydystrophic dwarfism; MIM:253200) is an autosomal recessive lysosomal storage disorder caused by a deficiency in arylsulfatase B (ARSB, N-acetyl-galactosamine 4-sulfatase; MIM:611542). It is named after two French physicians, Pierre Maroteaux and Maurice Emil Joseph Lamy. Maroteaux first described this disorder as a novel dysostosis associated with increased urinary excretion of chondroitin sulfate (CS; Maroteaux et al. 1963). The gene encoding ARSB is mapped to chromosome 5q11-q13 (Fidzianska et al. 1984) and contains 8 exons spanning about 206 kb (Karangeorgos et al. 2007). Defective ARSB results in build up of dermatan sulfate (DS) and chondroitin sulfate (CS) in soft tissues causing compression and blockages in blood vessels, nerves, trachea, corneal clouding and disrupting normal bone development. Symptoms are similar to MPS I but with normal intelligence generally (Rapini et al. 2007, Valayannopoulos et al. 2010).

Evidence510
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/7693577
xref: http://identifiers.org/pubmed/10571006
xref: http://identifiers.org/pubmed/3143362
xref: PublicationXref799
xref: http://identifiers.org/pubmed/17309651
xref: http://identifiers.org/pubmed/1909089
comment: Defects in beta-galactosidase (GLB1; MIM:611458) can result in GM1 gangliosidosis (GM1; MIM:230500) (Nishimoto et al. 1991) (not described here), with several phenotypes indicating mental deterioration, as well as in mucopolysaccharidosis IVB, a characteristic mucopolysaccharidosis with no neurological symptoms (Callahan 1999). Mucopolysaccharidosis IVB (MPS IVB, Morquio's syndrome B; MIM:253010) is a rare, autosomal recessive mucopolysaccharide storage disease characterized by intracellular accumulation of keratan sulfate (KS), skeletal dysplasia and corneal clouding. There is no central nervous system involvement, intelligence is normal and there is increased KS excretion in urine (Suzuki et al. "Beta-galactosidase deficiency (beta-galactosidosis): GM1 gangliosidosis and Morquio B disease", p3775-3809 in Stryer et al. 2001). MPSIVB is caused by a defect in betagalactosidase (GLB1), which normally cleaves terminal galactosyl residues from glycosaminoglycans, gangliosides and glycoproteins. The GLB1 gene spans 62.5 kb and contains 16 exons (Oshima et al.1988, Santamaria et al. 2007) and maps to chromosome 3p21.33 (Takano & Yamanouchi 1993).

UnificationXref1307
type: UnificationXref
id: CHEBI:16577
db: ChEBI

Evidence513
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10339581
xref: http://identifiers.org/pubmed/8793927
comment: Mucopolysaccharidosis type IX (MPS IX, Natowicz syndrome, Hyaluronidase deficiency, MIM:601492) is a rare lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum resulting from deficiency in hyaluronidase 1 (HYAL1, MIM:607071) which normally hydrolyses 1-4 linkages between N-acetylglucosamine (GlcNAc) and D-glucuronate (GlcA) residues. Symptoms of MPS IX are periodically painful soft tissue masses around the joints, acquired short stature and erosion of the hip joint, although joint movement and intelligence are normal (Natowicz et al. 1996, Triggs-Raine et al. 1999).

UnificationXref1308
type: UnificationXref
id: 193505
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193505

Evidence512
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8644704
xref: http://identifiers.org/pubmed/4265197
xref: http://identifiers.org/pubmed/8565635
xref: http://identifiers.org/pubmed/19224584
xref: http://identifiers.org/pubmed/7680524
xref: http://identifiers.org/pubmed/12522561
xref: http://identifiers.org/pubmed/2347593
comment: Mucopolysaccharidosis type VII (MPS VII, Sly syndrome, beta-glucuronidase deficiency; MIM:253220) is an autosomal recessive lysosomal storage disease characterized by a deficiency of the enzyme beta-glucuronidase (GUSB; MIM:611499) which would normally cleave glucuronide residues from dematan sulphate, keratan sulphate and chondroitin sulphate, resulting in build up of these GAGs in cells and tissues (Sly et al. 1973). The gene encoding GUSB is 21 kb long, contains 12 exons and gives rise to two different types of cDNAs, through an alternate splicing mechanism (Miller et al. 1990). It maps to 7q11.21-q11.22 (Speleman et al. 1996). The phenotype is highly variable, ranging from severe causing death, non-immune hydrops fetalis (Vervoort et al. 1996) to mild forms with survival into adulthood (Storch et al. 2003). Most patients with the intermediate phenotype show hepatomegaly, skeletal anomalies, coarse facies, and variable degrees of mental impairment (Shipley et al. 1993, Tomatsu et al. 2009).

UnificationXref1305
type: UnificationXref
id: 4234639
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4234639

Evidence515
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11756445
xref: http://identifiers.org/pubmed/15949819
xref: http://identifiers.org/pubmed/14611934
xref: http://identifiers.org/pubmed/9778132
xref: http://identifiers.org/pubmed/16527816
xref: http://identifiers.org/pubmed/14634025
comment: The outer segment of photoreceptor cells is shed every 10-14 days to be completely replaced. The shed material is phagocytosed and transferred to the retinal pigment epithelium (RPE). Diretinoid-pyridinium-phosphatidylethanolamine (A2PE) can be hydrolysed to diretinoid-pyridinium-ethanolamine (A2E), a prominent constituent of lipofuscin (the material deposited in retinal tissue which accumulates over time and is implicated in macular degeneration). Evidence suggests this happens before transfer to RPE cells as part of the phagocytosed outer segment. A2E has been detected in outer segments (Ben-Shabat et al. 2002) and an N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPEPLD) activity detected in rat, mouse and human proteins (Okamoto et al. 2004, Ueda et al. 2005, Wang et al. 2006). This activity has been shown to hydrolyse A2PE to A2E in bovine outer segments before phagocytosis and transfer to RPE cells, suggesting A2PE is hydrolysed to A2E in photoreceptor outer segment membranes (Sparrow et al. 2003, Salvador & Giusto 1998).

UnificationXref1306
type: UnificationXref
id: REACT_110400
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_110400.9

Evidence514
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/22013531
xref: http://identifiers.org/pubmed/22210669
xref: PublicationXref817
xref: http://identifiers.org/pubmed/16414358
xref: http://identifiers.org/pubmed/19111581
xref: http://identifiers.org/pubmed/22210670
comment: The mucopolysaccharidoses (MPS) are a group of rare, inherited lysosomal storage disorders caused by deficiencies of enzymes catalyzing the stepwise degradation of glycosaminoglycans (GAGs, originally called mucopolysaccharides) (Neufeld & Muenzer in Scriver et al. 2001). Catabolism of the GAGs dermatan sulfate, heparan sulfate, heparin, keratan sulfate, chondroitin sulfate or hyaluronan may be blocked at one or more steps, resulting in lysosomal accumulation of GAG fragments of varying size. Over time these collect in the cells, blood and connective tissues ultimately resulting in progressive irreversible cellular damage which affects appearance, physical abilities, organ and system function, vision, and usually mental development (Lehman et al. 2011, Ashworth et al. 2006). Life expectancy is also reduced. There are 11 known enzyme deficiencies that give rise to 7 distinct MPS. These disorders are biochemically characterized by elevated levels of partially or undegraded GAGs in lysosomes, blood, urine and cerebro-spinal fluid (Muenzer 2011, Coutinho et al. 2012). The MPS are part of the lysosomal storage disease family, a group of about 50 genetic disorders caused by deficient lysosomal proteins (Ballabio & Gieselmann 2009).

UnificationXref1303
type: UnificationXref
id: 111294
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111294

Evidence517
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18632300
xref: http://identifiers.org/pubmed/16968212
xref: http://identifiers.org/pubmed/20435355
xref: http://identifiers.org/pubmed/21377628
comment: The gene defects which cause diseases related to the retinoid cycle are described here (Travis et al. 2007, Palczewski 2010, Fletcher et al. 2011, den Hollander et al. 2008).

UnificationXref1304
type: UnificationXref
id: REACT_5692
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5692.2

Evidence516
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/20134024
xref: http://identifiers.org/pubmed/19666736
xref: http://identifiers.org/pubmed/22209824
comment: Lipofuscin is a yellow-brown pigment grain composed mainly of lipids but also sugars and certain metals. Accumulation of lipofuscin is associated with degenerative diseases such as Alzheimer's disease, Parkinson's disease, chronic obstructive pulmonary disease and retinal macular degeneration. A prominent component of lipofuscin in retinal pigment epithelial (RPE) cells is the bisretinoid A2E (di-retinoid-pyridinium-ethanolamine), the end-product of the condensation of 2 molecules of all-trans-retinal (atRAL) and phosphatidylethanolamine (PE) in photoreceptor outer disc membranes. Once formed, A2E is phagocytosed, together with outer segments (Kevany & Palczewski 2010), to RPE where it accumulates. There is no evidence as yet to indicate that A2E can be catabolised (Sparrow et al. 2012, Sparrow et al. 2010). A simplified biosynthetic pathway for A2E is described here.

UnificationXref1310
type: UnificationXref
id: CHEBI:15494
db: ChEBI

PublicationXref488
type: PublicationXref
id: 0121227022
author: Anderson, EP
db: ISBN
title: Nucleoside and nucleotide kinases
source: The Enzymes, 3rd ed (Book): 49-96
year: 1973

UnificationXref1311
type: UnificationXref
id: 193457
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193457

Evidence509
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8325655
xref: http://identifiers.org/pubmed/8001980
xref: http://identifiers.org/pubmed/4218100
xref: http://identifiers.org/pubmed/21506915
xref: http://identifiers.org/pubmed/8020961
xref: http://identifiers.org/pubmed/18456538
comment: Mucopolysaccharidosis IV A (MPS IVA, MPS4A, Morquio's syndrome, Morquio's; MIM:253000) is a rare, autosomal recessive mucopolysaccharide storage disease, first described simultaneously in 1929 by L Morquio (Morquio L, Sur une forme de distrophie familiale, Bull Soc Pediat, Paris, 27, 1929, 145-152) and JF Brailsford (Brailsford, JF, Chondro-osteo-dystrophy: roentgenographic and clinical features of child with dislocation of vertebrae, Am j Surg, 7, 1929, 404-410). MPSIVA is caused by a deficiency in N-acetylgalactosamine 6-sulfatase (GALNS; MIM:612222) which normally hydrolyses 6-sulfate groups of N-acetylgalactosamine 6-sulfate units of chondroitin sulfate (CS) and of galactose 6-sulfate units of keratan sulfate (KS) (Matalon et al. 1974). The result is accumulation of KS/DS in cells and overexcretion in urine. Severe osteochondrodysplasia is a commonly seen phenotype for this disease. The severity of the disease is variable but severe cases limits lifespan to their 20's or 30's (Prat et al. 2008, Tomatsu et al. 2011). The gene coding for human GALNS was mapped to chromosome 16q24.3 (Masuno et al. 1993) and its structure described at the same time by two independent groups as comprising 14 exons and spanning approximately 40-50 kb (Nakashima et al.1994, Morris et al.1994).

(S)-4,5-Dihydroorotate
type: SmallMoleculeReference
name: Dihydro-L-orotic acid
name: (S)-Dihydroorotate
name: L-Dihydroorotic acid
name: (S)-Dihydroorotate [ChEBI:17025]
name: L-Dihydroorotate
xref: UnificationXref2092

UnificationXref1312
type: UnificationXref
id: REACT_10348
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10348.1

Evidence508
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/21235449
xref: http://identifiers.org/pubmed/3391615
xref: http://identifiers.org/pubmed/9329460
xref: http://identifiers.org/pubmed/12573255
xref: http://identifiers.org/pubmed/6450420
comment: Mucopolysaccharidosis III (Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837-838, 1963, no reference). Mucopolysaccharidosis type IIID (MPS IIID, Sanfilippo syndrome D, MIM:252940) is an autosomal recessive genetic disorder due to the loss of N-acetyl-D-glucosamine 6-sulfatase (GNS; MIM:607664), that hydrolyses the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of the glycosaminoglycans (GAGs) heparan sulfate and keratan sulfate. GNS is localized to chromosome 12q14 and has 14 exons spanning 46 kb (Robertson et al. 1988, Mok et al. 2003). Loss of enzyme activity leads to lysosomal accumulation and urinary excretion of heparan sulfate and N-acetylglucosamine 6-sulfate residues (Mok et al. 2003). Keratan sulphate does not accumulate in MPS IIID, as beta-linked N-acetyl-D-glucosamine 6-sulphate can be cleaved by beta-hexosaminidase A (Kresse et al. 1980). This disorder is characterized by progressive mental deterioration but only moderate physical abnormalities and death duing the second or third decade of life, presenting a phenotype similar to MPSIIIA (Jones et al. 1997, de Ruijter et al. 2011).