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aminomuconate-semialdehyde dehydrogenase
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gene ontology term for cellular function
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2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+
This reaction has been characterized in vitro using enzyme partially purified from cat liver (Ichiyama et al. 1965). The human event is inferred from the cat one. Neither the cat nor the human protein has been fully purified or sequenced.
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2-Aminomuconate semialdehyde [ChEBI:15745]
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Studies on the metabolism of the benzene ring of tryptophan in mammalian tissues. II. Enzymatic formation of alpha-muconic acid from 2-hydroxyanthranilic acid