UnificationXref1585
type: UnificationXref
id: 4231562
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231562

UnificationXref1584
type: UnificationXref
id: MOD:00128
db: MOD

UnificationXref1583
type: UnificationXref
id: P04693
db: UniProt

UnificationXref1582
type: UnificationXref
id: REACT_80842
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80842.9

UnificationXref1589
type: UnificationXref
id: 4231566
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231566

http://identifiers.org/pubmed/19837038
type: PublicationXref
id: 19837038
author: Ashley, James
author: Ataman, Bulent
author: Budnik, Vivian
author: Ramachandran, Preethi
author: Gherbesi, Norberto
author: Barria, Romina
author: Korkut, Ceren
db: Pubmed
title: Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless
source: Cell 139:393-404
year: 2009

UnificationXref1588
type: UnificationXref
id: 4231565
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231565

UnificationXref1587
type: UnificationXref
id: 4231564
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231564

UnificationXref1586
type: UnificationXref
id: P00509
db: UniProt

UnificationXref2112
type: UnificationXref
id: 4231943
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231943

UniProt:P24186
type: ProteinReference
xref: UnificationXref3287
organism: BioSource1

UnificationXref2113
type: UnificationXref
id: 4231944
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231944

UnificationXref2110
type: UnificationXref
id: REACT_5013
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5013.1

UnificationXref2111
type: UnificationXref
id: Q46911
db: UniProt

UnificationXref2116
type: UnificationXref
id: 4231947
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231947

UnificationXref1581
type: UnificationXref
id: 4231767
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231767

UniProt:P24182
type: ProteinReference
xref: UnificationXref1559
organism: BioSource1

UnificationXref2117
type: UnificationXref
id: REACT_114844
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114844.8

UnificationXref1580
type: UnificationXref
id: 4231612
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231612

UnificationXref2114
type: UnificationXref
id: 4231940
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231940

UnificationXref2115
type: UnificationXref
id: 4231945
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231945

UnificationXref2119
type: UnificationXref
id: 390440
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390440

UnificationXref2118
type: UnificationXref
id: CHEBI:16125
db: ChEBI

UnificationXref1594
type: UnificationXref
id: 76213
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76213

(5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
type: SmallMoleculeReference
name: Prostaglandin D2
name: (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate [ChEBI:246]
xref: UnificationXref2260

UnificationXref1593
type: UnificationXref
id: REACT_5182
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5182.4

UnificationXref1596
type: UnificationXref
id: 4231552
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231552

Prostaglandin F2a
type: SmallMoleculeReference
name: Prostaglandin F2alpha
name: Enzaprost
name: Prostin F 2 alpha
name: Prostaglandin F2
name: (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate
name: PGF2a
name: Prostarmon F
name: Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-,(5Z,9a,11a,13E,15S)-
name: Prostaglandin F2alpha [ChEBI:8516]
name: U 14583
name: 9a,11a-PGF2
name: Dinoprost
name: Protamodin
name: 5-Heptenoic acid, 7-[3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-
name: Panacelan
name: Cyclosin
name: (+)-Prostaglandin F2a
name: Enzaprost F
name: 7-[3, 5-dihydroxy-2-(3-hydroxy-1-octenyl) cyclopentyl]-5-heptenoic acid
name: Amoglandin
xref: UnificationXref2266

UnificationXref1595
type: UnificationXref
id: REACT_5376
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5376.2

UnificationXref1598
type: UnificationXref
id: 4231556
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231556

Prostaglandin E2 [ChEBI:8512]
type: SmallMoleculeReference
name: (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate
name: Prostaglandin E2
name: (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate
xref: UnificationXref2263

Beta-oxidation of very long chain fatty acids
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction174
pathway component: BiochemicalReaction175
evidence: Evidence330
xref: RelationshipXref264
xref: UnificationXref2100
xref: UnificationXref2099
pathway order: PathwayStep314
pathway order: PathwayStep316
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1597
type: UnificationXref
id: 4231555
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231555

(5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprostanoate
type: SmallMoleculeReference
name: (5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprostanoate [ChEBI:244]
xref: UnificationXref2291

UnificationXref2120
type: UnificationXref
id: REACT_18226
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18226.2

UnificationXref1599
type: UnificationXref
id: 4231557
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231557

UnificationXref2121
type: UnificationXref
id: CHEBI:15756
db: ChEBI

UnificationXref2122
type: UnificationXref
id: 390435
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390435

UnificationXref2123
type: UnificationXref
id: REACT_17312
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17312.2

UnificationXref2124
type: UnificationXref
id: CHEBI:17197
db: ChEBI

UnificationXref2125
type: UnificationXref
id: 390409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390409

UnificationXref1590
type: UnificationXref
id: 4231590
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231590

UnificationXref2126
type: UnificationXref
id: REACT_17713
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17713.2

UnificationXref2127
type: UnificationXref
id: 4232494
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232494

UnificationXref1592
type: UnificationXref
id: 29406
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29406

UnificationXref2128
type: UnificationXref
id: REACT_114920
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114920.8

UnificationXref1591
type: UnificationXref
id: REACT_83266
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83266.9

UnificationXref2129
type: UnificationXref
id: 4233356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233356

http://identifiers.org/pubmed/15269313
type: PublicationXref
id: 15269313
author: Harstrick, A
author: Khayat, D
author: Bleiberg, H
author: Verslype, C
author: Mueser, M
author: Van Cutsem, E
author: Chau, I
author: Santoro, A
author: Siena, S
author: Cunningham, D
author: Humblet, Y
author: Bets, D
db: Pubmed
title: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
source: N Engl J Med 351:337-45
year: 2004

(5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate [ChEBI:249]
type: SmallMoleculeReference
name: (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
xref: UnificationXref2271

(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
type: SmallMoleculeReference
name: (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
name: (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate [ChEBI:147]
xref: UnificationXref2364

UnificationXref1567
type: UnificationXref
id: 4231524
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231524

UnificationXref1566
type: UnificationXref
id: REACT_4600
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4600.2

UnificationXref1565
type: UnificationXref
id: 113527
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113527

UnificationXref1564
type: UnificationXref
id: CHEBI:18291
db: ChEBI

UnificationXref1563
type: UnificationXref
id: REACT_3612
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3612.3

UnificationXref1562
type: UnificationXref
id: 29582
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29582

UnificationXref1561
type: UnificationXref
id: CHEBI:15956
db: ChEBI

UnificationXref1560
type: UnificationXref
id: 4231523
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231523

UnificationXref1568
type: UnificationXref
id: 4231526
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231526

UnificationXref1569
type: UnificationXref
id: REACT_159665
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159665.3

UnificationXref1576
type: UnificationXref
id: 113544
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113544

UnificationXref1575
type: UnificationXref
id: CHEBI:30797
db: ChEBI

UnificationXref1578
type: UnificationXref
id: P61889
db: UniProt

UnificationXref1577
type: UnificationXref
id: REACT_4778
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4778.2

UnificationXref1572
type: UnificationXref
id: REACT_3839
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3839.2

UnificationXref1571
type: UnificationXref
id: 113559
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113559

UnificationXref1574
type: UnificationXref
id: REACT_5847
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5847.1

UnificationXref1573
type: UnificationXref
id: 113529
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113529

UnificationXref2103
type: UnificationXref
id: CHEBI:15525
db: ChEBI

UnificationXref2104
type: UnificationXref
id: 390426
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390426

UnificationXref2105
type: UnificationXref
id: REACT_18126
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18126.2

UnificationXref1570
type: UnificationXref
id: 4231527
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231527

UnificationXref2106
type: UnificationXref
id: CHEBI:17868
db: ChEBI

http://identifiers.org/pubmed/19075029
type: PublicationXref
id: 19075029
author: Li, S
author: Konrad, RJ
author: Cao, G
author: Zhao, Y
author: Chen, YQ
db: Pubmed
title: The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids
source: J Lipid Res 50:945-56
year: 2009

UnificationXref2100
type: UnificationXref
id: REACT_30695
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30695.10

ChEBI:29265 Asn-tRNA(Asn)
type: SmallMoleculeReference
name: Asn-tRNA(Asn)
xref: UnificationXref842

UnificationXref2101
type: UnificationXref
id: 390404
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390404

UnificationXref2102
type: UnificationXref
id: REACT_17976
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17976.2

UniProt:P29680
type: ProteinReference
xref: UnificationXref3663
organism: BioSource1

http://identifiers.org/pubmed/1849145
type: PublicationXref
id: 1849145
author: Maury, CP
db: Pubmed
title: Gelsolin-related amyloidosis. Identification of the amyloid protein in Finnish hereditary amyloidosis as a fragment of variant gelsolin
source: J Clin Invest 87:1195-9
year: 1991

UnificationXref2108
type: UnificationXref
id: REACT_17592
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17592.1

UnificationXref2107
type: UnificationXref
id: 390419
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390419

UnificationXref2109
type: UnificationXref
id: 141335
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=141335

6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol [ChEBI:64181]
type: SmallMoleculeReference
name: 6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol
xref: UnificationXref2503

2-methoxy-6-decaprenyl-1,4-benzoquinol [ChEBI:64180]
type: SmallMoleculeReference
name: 2-methoxy-6-decaprenyl-1,4-benzoquinol
xref: UnificationXref2500

ubiquinol-10 [ChEBI:64183]
type: SmallMoleculeReference
name: ubiquinol-10
xref: UnificationXref2513

3-demethylubiquinol-10
type: SmallMoleculeReference
name: 3-demethylubiquinol-10 [ChEBI:64182]
xref: UnificationXref2510

http://identifiers.org/pubmed/11158296
type: PublicationXref
id: 11158296
author: Pelzer, W
author: Kmita, H
author: Diekert, K
author: Bedekovics, T
author: Lill, R
author: Prohl, C
author: Kispal, G
db: Pubmed
title: The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix
source: Mol Cell Biol 21:1089-97
year: 2001

UnificationXref1579
type: UnificationXref
id: 4231611
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231611

http://identifiers.org/pubmed/3196333
type: PublicationXref
id: 3196333
author: Morris, CP
author: Hopwood, JJ
author: Robertson, DA
author: Freeman, C
author: Nelson, PV
db: Pubmed
title: Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase
source: Biochem Biophys Res Commun 157:218-24
year: 1988

ChEBI:37154 fumarate(1-)
type: SmallMoleculeReference
name: fumarate(1-)
xref: UnificationXref3506

Thymine
type: SmallMoleculeReference
name: Thymine [ChEBI:17821]
xref: UnificationXref315

UnificationXref121
type: UnificationXref
id: 29432
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29432

UnificationXref122
type: UnificationXref
id: REACT_3437
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3437.2

UnificationXref120
type: UnificationXref
id: REACT_14522
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14522.2

carbovir diphosphate [ChEBI:64172]
type: SmallMoleculeReference
name: carbovir diphosphate
xref: UnificationXref3883

UnificationXref129
type: UnificationXref
id: CHEBI:17561
db: ChEBI

UnificationXref127
type: UnificationXref
id: 351990
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=351990

UnificationXref128
type: UnificationXref
id: REACT_14295
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14295.2

UnificationXref125
type: UnificationXref
id: REACT_11439
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11439.2

UnificationXref126
type: UnificationXref
id: CHEBI:16857
db: ChEBI

UnificationXref123
type: UnificationXref
id: CHEBI:17115
db: ChEBI

UnificationXref124
type: UnificationXref
id: 200736
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=200736

http://identifiers.org/pubmed/10075721
type: PublicationXref
id: 10075721
author: McKay, DJ
author: Bin, JC
author: Snyder, FF
author: Yuan, G
db: Pubmed
title: Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein.
source: J Biol Chem 274:8175-80
year: 1999

UnificationXref130
type: UnificationXref
id: 111707
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111707

UnificationXref131
type: UnificationXref
id: REACT_7424
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7424.3

UnificationXref132
type: UnificationXref
id: 352355
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=352355

http://identifiers.org/pubmed/3954355
type: PublicationXref
id: 3954355
author: Bergholte, JM
author: Okita, RT
db: Pubmed
title: Isolation and properties of lung 15-hydroxyprostaglandin dehydrogenase from pregnant rabbits
source: Arch Biochem Biophys 245:308-15
year: 1986

UnificationXref133
type: UnificationXref
id: REACT_14614
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14614.1

Inositol phosphate metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 159925.3
evidence: Evidence279
xref: UnificationXref1782
xref: RelationshipXref227
xref: UnificationXref1783
pathway order: PathwayStep265
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref138
type: UnificationXref
id: 352016
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=352016

UnificationXref139
type: UnificationXref
id: REACT_14096
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14096.2

UnificationXref134
type: UnificationXref
id: 352002
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=352002

UnificationXref135
type: UnificationXref
id: REACT_13949
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13949.2

UnificationXref136
type: UnificationXref
id: 352000
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=352000

UnificationXref137
type: UnificationXref
id: REACT_14192
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14192.2

http://identifiers.org/pubmed/10706561
type: PublicationXref
id: 10706561
author: Akagi, R
author: Doss, MO
author: Shimizu, R
author: Furuyama, K
author: Sassa, S
db: Pubmed
title: Novel molecular defects of the delta-aminolevulinate dehydratase gene in a patient with inherited acute hepatic porphyria
source: Hepatology 31:704-8
year: 2000

UnificationXref109
type: UnificationXref
id: 4232580
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232580

Mucopolysaccharidoses
type: Pathway
data source: Provenance1
pathway component: MPS IX - Natowicz syndrome
pathway component: REACT 149129.4
pathway component: REACT 149817.4
pathway component: REACT 148726.4
pathway component: MPS IIIC - Sanfilippo syndrome C
pathway component: REACT 148882.4
pathway component: REACT 149060.4
pathway component: MPS IIIB - Sanfilippo syndrome B
pathway component: REACT 148715.4
pathway component: REACT 148756.4
pathway component: REACT 149347.4
evidence: Evidence226
xref: UnificationXref1429
xref: UnificationXref1428
pathway order: PathwayStep207
pathway order: PathwayStep212
pathway order: PathwayStep208
pathway order: PathwayStep205
pathway order: PathwayStep209
pathway order: PathwayStep213
pathway order: PathwayStep204
pathway order: PathwayStep203
pathway order: PathwayStep211
pathway order: PathwayStep210
pathway order: PathwayStep206
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

17-Demethoxy-17-allylamino geldanamycin
type: SmallMoleculeReference
name: 17AAG
name: tanespimycin [ChEBI:64153]
name: 17-N-allylamino-17-demethoxygeldanamycin
name: 17-allylaminogeldanamycin
name: 17-(Allylamino)geldanamycin
name: 17-(Allylamino)-17-demethoxygeldanamycin
name: 17-AAG
name: 17-demethoxy-17-(2-propenylamino)geldanamycin
name: tanespimycin
xref: UnificationXref1252

UnificationXref100
type: UnificationXref
id: 4232576
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232576

UnificationXref103
type: UnificationXref
id: REACT_112212
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112212.8

UnificationXref104
type: UnificationXref
id: CHEBI:18367
db: ChEBI

UnificationXref101
type: UnificationXref
id: 4232577
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232577

UnificationXref102
type: UnificationXref
id: 4232579
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232579

UnificationXref107
type: UnificationXref
id: 29372
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372

UnificationXref108
type: UnificationXref
id: REACT_2728
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2728.2

UnificationXref105
type: UnificationXref
id: 109277
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109277

UniProt:P0AD61
type: ProteinReference
xref: UnificationXref198
organism: BioSource1

UnificationXref106
type: UnificationXref
id: REACT_5727
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5727.2

http://identifiers.org/pubmed/9771708
type: PublicationXref
id: 9771708
author: Ahmad, W
author: Swank, RT
author: Krakow, D
author: King, LM
author: Cohn, DH
author: Abbas, H
author: Ahmad, M
author: Rusiniak, ME
author: Superti-Furga, A
author: Cantor, RM
author: ul Haque, MF
author: Haque, S
db: Pubmed
title: Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse
source: Nat Genet 20:157-62
year: 1998

D-Glycerate 2-phosphate
type: SmallMoleculeReference
name: 2-Phospho-D-glycerate [ChEBI:17835]
name: 2-Phospho-D-glycerate
xref: UnificationXref1505

UnificationXref110
type: UnificationXref
id: 4232581
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232581

UnificationXref111
type: UnificationXref
id: 4232582
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232582

http://identifiers.org/pubmed/12681240
type: PublicationXref
id: 12681240
author: Quinton, TM
author: Kim, S
author: Kunapuli, SP
author: Dorsam, RT
db: Pubmed
title: Platelet purinergic receptors
source: Curr Opin Pharmacol 3:175-80
year: 2003

UnificationXref112
type: UnificationXref
id: 4232583
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232583

UnificationXref113
type: UnificationXref
id: 4232584
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232584

UnificationXref114
type: UnificationXref
id: 4232586
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232586

UnificationXref115
type: UnificationXref
id: REACT_114049
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114049.8

UnificationXref116
type: UnificationXref
id: 4233452
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233452

UnificationXref117
type: UnificationXref
id: REACT_112940
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112940.8

UnificationXref118
type: UnificationXref
id: CHEBI:16977
db: ChEBI

http://identifiers.org/pubmed/12754312
type: PublicationXref
id: 12754312
author: Blank, ME
author: Ehmke, H
db: Pubmed
title: Aquaporin-1 and HCO3(-)-Cl- transporter-mediated transport of CO2 across the human erythrocyte membrane
source: J Physiol 550:419-29
year: 2003

http://identifiers.org/pubmed/15385440
type: PublicationXref
id: 15385440
author: Lathrop, M
author: Fischer, J
author: Halliez, S
author: Prud'homme, JF
author: Ozguc, M
author: Yalçinkayal, C
author: Topçu, M
author: Jobard, F
author: Coskun, T
author: Wanders, RJ
author: Gerceker, FO
db: Pubmed
title: L-2-Hydroxyglutaric aciduria: identification of a mutant gene C14orf160, localized on chromosome 14q22.1
source: Hum Mol Genet 13:2803-11
year: 2004

UnificationXref119
type: UnificationXref
id: 352036
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=352036

UnificationXref3649
type: UnificationXref
id: CHEBI:36319
db: ChEBI

UnificationXref3647
type: UnificationXref
id: 189449
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189449

UnificationXref3648
type: UnificationXref
id: REACT_9601
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9601.2

UnificationXref168
type: UnificationXref
id: 4233438
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233438

Purine metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 95719.9
pathway component: REACT 28847.10
pathway component: REACT 32997.10
evidence: Evidence440
xref: RelationshipXref404
xref: UnificationXref2896
xref: UnificationXref2897
pathway order: PathwayStep426
pathway order: PathwayStep419
pathway order: PathwayStep411
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref167
type: UnificationXref
id: MI:0359
db: MI

UnificationXref169
type: UnificationXref
id: REACT_107270
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107270.9

http://identifiers.org/pubmed/22216413
type: PublicationXref
id: 22216413
author: Erickson, M
author: Stern, R
db: Pubmed
title: Chain gangs: new aspects of hyaluronan metabolism
source: Biochem Res Int 2012:893947
year: 2012

UnificationXref164
type: UnificationXref
id: REACT_91869
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91869.9

UnificationXref163
type: UnificationXref
id: 4232377
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232377

UnificationXref166
type: UnificationXref
id: REACT_107449
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107449.9

UnificationXref165
type: UnificationXref
id: 4233437
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233437

UnificationXref160
type: UnificationXref
id: 4232374
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232374

UnificationXref162
type: UnificationXref
id: REACT_105231
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105231.9

UnificationXref161
type: UnificationXref
id: 4232376
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232376

UnificationXref2190
type: UnificationXref
id: REACT_143960
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143960.5

UnificationXref2191
type: UnificationXref
id: 4233513
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233513

UnificationXref2192
type: UnificationXref
id: REACT_142808
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142808.5

UnificationXref2193
type: UnificationXref
id: CHEBI:17962
db: ChEBI

UnificationXref2194
type: UnificationXref
id: 1524064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524064

UnificationXref2195
type: UnificationXref
id: REACT_124717
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124717.1

UnificationXref2196
type: UnificationXref
id: CHEBI:37393
db: ChEBI

UnificationXref2197
type: UnificationXref
id: 1524059
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524059

UnificationXref3642
type: UnificationXref
id: 189464
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189464

UnificationXref2198
type: UnificationXref
id: REACT_121430
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121430.1

UnificationXref3641
type: UnificationXref
id: CHEBI:17381
db: ChEBI

UnificationXref2199
type: UnificationXref
id: CHEBI:17361
db: ChEBI

UnificationXref3640
type: UnificationXref
id: REACT_9717
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9717.2

UnificationXref3646
type: UnificationXref
id: CHEBI:16645
db: ChEBI

UnificationXref3645
type: UnificationXref
id: REACT_30060
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30060.10

UnificationXref3644
type: UnificationXref
id: 4232235
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232235

UnificationXref3643
type: UnificationXref
id: REACT_9816
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9816.2

UnificationXref3658
type: UnificationXref
id: 189407
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189407

http://identifiers.org/pubmed/19319844
type: PublicationXref
id: 19319844
author: Zempleni, J
author: Hassan, YI
author: Wijeratne, SS
db: Pubmed
title: Biotin
source: Biofactors 35:36-46
year: 2009

UnificationXref3659
type: UnificationXref
id: REACT_9722
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9722.2

UnificationXref179
type: UnificationXref
id: CHEBI:16474
db: ChEBI

UnificationXref178
type: UnificationXref
id: REACT_26419
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26419.2

UnificationXref177
type: UnificationXref
id: 975622
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=975622

UnificationXref176
type: UnificationXref
id: CHEBI:17898
db: ChEBI

UnificationXref175
type: UnificationXref
id: REACT_168581
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_168581.1

UnificationXref174
type: UnificationXref
id: 4233474
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233474

UnificationXref173
type: UnificationXref
id: REACT_166020
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_166020.1

UnificationXref172
type: UnificationXref
id: 4233473
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233473

UnificationXref171
type: UnificationXref
id: REACT_168104
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_168104.1

UnificationXref170
type: UnificationXref
id: 4233472
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233472

http://identifiers.org/pubmed/6105839
type: PublicationXref
id: 6105839
author: Jones, ME
db: Pubmed
title: Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis.
source: Annu Rev Biochem 49:253-79
year: 1980

UnificationXref180
type: UnificationXref
id: 29364
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29364

http://identifiers.org/pubmed/16169847
type: PublicationXref
id: 16169847
author: Treadwell, L
author: Warrington, JA
author: Wolfe, CL
author: Norcum, MT
db: Pubmed
title: A three-dimensional working model of the multienzyme complex of aminoacyl-tRNA synthetases based on electron microscopic placements of tRNA and proteins
source: J Biol Chem 280:38870-8
year: 2005

UnificationXref3651
type: UnificationXref
id: REACT_9774
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9774.2

UnificationXref3650
type: UnificationXref
id: 189447
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189447

UnificationXref3653
type: UnificationXref
id: 4232214
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232214

UnificationXref3652
type: UnificationXref
id: P06983
db: UniProt

UnificationXref3655
type: UnificationXref
id: 4232217
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232217

UnificationXref3654
type: UnificationXref
id: 4232215
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232215

UnificationXref3657
type: UnificationXref
id: CHEBI:15437
db: ChEBI

UnificationXref3656
type: UnificationXref
id: REACT_112987
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112987.8

UnificationXref146
type: UnificationXref
id: REACT_92633
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92633.9

UnificationXref145
type: UnificationXref
id: 4232370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232370

UnificationXref3629
type: UnificationXref
id: CHEBI:27889
db: ChEBI

UnificationXref148
type: UnificationXref
id: REACT_97431
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97431.9

UnificationXref147
type: UnificationXref
id: 4232369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232369

UnificationXref3627
type: UnificationXref
id: 4233319
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233319

UnificationXref3628
type: UnificationXref
id: REACT_103710
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103710.9

UnificationXref149
type: UnificationXref
id: 4232368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232368

UnificationXref3625
type: UnificationXref
id: 4233499
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233499

UnificationXref3626
type: UnificationXref
id: REACT_118099
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118099.7

UnificationXref140
type: UnificationXref
id: 352359
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=352359

UnificationXref142
type: UnificationXref
id: 4232364
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232364

UnificationXref141
type: UnificationXref
id: REACT_14477
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14477.1

UnificationXref144
type: UnificationXref
id: 4232366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232366

http://identifiers.org/pubmed/7726158
type: PublicationXref
id: 7726158
author: Rosenblatt, DS
author: Rozen, R
author: Goyette, P
author: Frosst, P
db: Pubmed
title: Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency
source: Am J Hum Genet 56:1052-9
year: 1995

UnificationXref143
type: UnificationXref
id: 4232365
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232365

http://identifiers.org/pubmed/15153069
type: PublicationXref
id: 15153069
author: Lake, S
author: Climent, I
author: Swiezewska, E
author: Forsgren, M
author: Attersand, A
author: Dallner, G
author: Grünler, J
db: Pubmed
title: Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ
source: Biochem J 382:519-26
year: 2004

UnificationXref2172
type: UnificationXref
id: REACT_133571
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133571.5

UnificationXref2173
type: UnificationXref
id: 4233359
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233359

UnificationXref2174
type: UnificationXref
id: REACT_128297
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128297.5

UnificationXref2175
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

UnificationXref2170
type: UnificationXref
id: 4232996
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232996

UnificationXref2171
type: UnificationXref
id: 4232998
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232998

UnificationXref3624
type: UnificationXref
id: REACT_136193
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136193.5

UnificationXref3623
type: UnificationXref
id: 4233518
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233518

UnificationXref3622
type: UnificationXref
id: 4233136
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233136

2-Deoxy-D-ribose 1-phosphate
type: SmallMoleculeReference
name: 2-Deoxy-D-ribose 1-phosphate [ChEBI:28542]
xref: UnificationXref2791

UnificationXref3621
type: UnificationXref
id: REACT_126315
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126315.5

Fatty acid, triacylglycerol, and ketone body metabolism
type: Pathway
data source: Provenance1
pathway component: Triacylglycerol biosynthesis
pathway component: BiochemicalReaction172
pathway component: REACT 97665.9
pathway component: Ketone body metabolism
evidence: Evidence324
xref: UnificationXref2054
xref: RelationshipXref258
xref: UnificationXref2053
pathway order: PathwayStep309
pathway order: PathwayStep310
pathway order: PathwayStep303
pathway order: PathwayStep275
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3620
type: UnificationXref
id: 4233135
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233135

UnificationXref2176
type: UnificationXref
id: CHEBI:18303
db: ChEBI

UnificationXref2177
type: UnificationXref
id: 1500644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500644

UnificationXref2178
type: UnificationXref
id: REACT_123472
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123472.1

UnificationXref2179
type: UnificationXref
id: CHEBI:16038
db: ChEBI

UnificationXref159
type: UnificationXref
id: 4232373
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232373

UnificationXref158
type: UnificationXref
id: 4232372
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232372

UnificationXref157
type: UnificationXref
id: REACT_14409
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14409.2

UnificationXref156
type: UnificationXref
id: 212615
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=212615

UnificationXref3636
type: UnificationXref
id: 4232244
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232244

UnificationXref3637
type: UnificationXref
id: REACT_94488
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94488.9

UnificationXref3638
type: UnificationXref
id: CHEBI:17549
db: ChEBI

UnificationXref3639
type: UnificationXref
id: 189489
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189489

UnificationXref151
type: UnificationXref
id: 4232371
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232371

UnificationXref150
type: UnificationXref
id: REACT_107688
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107688.9

UnificationXref155
type: UnificationXref
id: REACT_2473
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2473.2

http://identifiers.org/pubmed/18555844
type: PublicationXref
id: 18555844
author: Buehrer, B
author: Madan, AK
author: Fain, JN
author: Bahouth, SW
author: Tichansky, DS
db: Pubmed
title: Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue
source: Metabolism 57:1005-15
year: 2008

UnificationXref154
type: UnificationXref
id: 29472
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29472

UnificationXref153
type: UnificationXref
id: CHEBI:18050
db: ChEBI

UnificationXref152
type: UnificationXref
id: REACT_86528
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86528.9

http://identifiers.org/pubmed/17266529
type: PublicationXref
id: 17266529
author: Hyde, JE
db: Pubmed
title: Targeting purine and pyrimidine metabolism in human apicomplexan parasites
source: Curr Drug Targets 8:31-47
year: 2007

UnificationXref2185
type: UnificationXref
id: 1500661
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500661

UnificationXref2186
type: UnificationXref
id: REACT_122049
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122049.1

UnificationXref2183
type: UnificationXref
id: 4233011
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233011

UnificationXref2184
type: UnificationXref
id: CHEBI:45360
db: ChEBI

UnificationXref2181
type: UnificationXref
id: REACT_124336
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124336.1

UnificationXref2182
type: UnificationXref
id: P0A8K1
db: UniProt

UnificationXref2180
type: UnificationXref
id: 1524083
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524083

UnificationXref3633
type: UnificationXref
id: 4232232
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232232

UnificationXref3632
type: UnificationXref
id: P0ACB2
db: UniProt

UnificationXref3635
type: UnificationXref
id: 4232243
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232243

UnificationXref3634
type: UnificationXref
id: 4232233
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232233

UnificationXref2189
type: UnificationXref
id: 4233015
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233015

UnificationXref3631
type: UnificationXref
id: REACT_9737
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9737.2

UnificationXref2187
type: UnificationXref
id: 4233012
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233012

UnificationXref3630
type: UnificationXref
id: 190173
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=190173

UnificationXref2188
type: UnificationXref
id: 4233013
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233013

3-Oxodecanoyl-CoA [ChEBI:28528]
type: SmallMoleculeReference
name: 3-Oxodecanoyl-CoA
xref: UnificationXref1912

UnificationXref3685
type: UnificationXref
id: REACT_9640
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9640.1

UnificationXref2155
type: UnificationXref
id: REACT_30876
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30876.10

UnificationXref3686
type: UnificationXref
id: 189481
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189481

UnificationXref2154
type: UnificationXref
id: 4233421
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233421

UnificationXref3683
type: UnificationXref
id: REACT_9886
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9886.2

UnificationXref2157
type: UnificationXref
id: REACT_100406
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100406.9

UnificationXref3684
type: UnificationXref
id: 189480
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189480

UnificationXref2156
type: UnificationXref
id: 4233422
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233422

UnificationXref3689
type: UnificationXref
id: 4232220
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232220

UnificationXref2159
type: UnificationXref
id: REACT_105895
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105895.9

UnificationXref2158
type: UnificationXref
id: 4233423
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233423

Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
type: Pathway
data source: Provenance1
pathway component: Passive Transport of Carbon Dioxide into the Cell by AQP1
evidence: Evidence582
xref: RelationshipXref581
xref: UnificationXref3864
xref: UnificationXref3865
pathway order: PathwayStep568
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3687
type: UnificationXref
id: REACT_9751
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9751.1

UnificationXref3688
type: UnificationXref
id: P36553
db: UniProt

http://identifiers.org/pubmed/21143159
type: PublicationXref
id: 21143159
author: Ferretti, MT
author: Canneva, F
author: Houle, D
author: Glabe, CG
author: Partridge, V
author: Ducatenzeiler, A
author: Leon, WC
author: Vercauteren, F
author: Cuello, AC
author: Arvanitis, DN
author: Szyf, M
author: Allard, S
author: Klein, WL
db: Pubmed
title: Transgenic mice as a model of pre-clinical Alzheimer's disease
source: Curr Alzheimer Res 8:4-23
year: 2011

UnificationXref3681
type: UnificationXref
id: CHEBI:15435
db: ChEBI

UnificationXref2151
type: UnificationXref
id: REACT_10619
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10619.1

UnificationXref3682
type: UnificationXref
id: 189478
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189478

UnificationXref2150
type: UnificationXref
id: 193451
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193451

UnificationXref2153
type: UnificationXref
id: REACT_99363
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99363.9

UnificationXref3680
type: UnificationXref
id: REACT_9897
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9897.3

UnificationXref2152
type: UnificationXref
id: 4232256
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232256

UnificationXref3694
type: UnificationXref
id: 189487
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189487

UnificationXref2168
type: UnificationXref
id: REACT_125018
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125018.1

UnificationXref3695
type: UnificationXref
id: REACT_9665
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9665.2

UnificationXref2167
type: UnificationXref
id: 1500580
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500580

UnificationXref3696
type: UnificationXref
id: 113531
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113531

UnificationXref2166
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

http://identifiers.org/pubmed/16756494
type: PublicationXref
id: 16756494
author: Waterham, HR
author: Wanders, RJ
db: Pubmed
title: Biochemistry of mammalian peroxisomes revisited
source: Annu Rev Biochem 75:295-332
year: 2006

UnificationXref3697
type: UnificationXref
id: REACT_4623
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4623.2

UnificationXref2165
type: UnificationXref
id: REACT_138159
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138159.5

http://identifiers.org/pubmed/16756495
type: PublicationXref
id: 16756495
author: Dobson, CM
author: Chiti, F
db: Pubmed
title: Protein misfolding, functional amyloid, and human disease
source: Annu Rev Biochem 75:333-66
year: 2006

UnificationXref3698
type: UnificationXref
id: 189444
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189444

UnificationXref3699
type: UnificationXref
id: REACT_9617
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9617.1

UnificationXref2169
type: UnificationXref
id: 4232995
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232995

UnificationXref2160
type: UnificationXref
id: 4233483
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233483

UnificationXref3690
type: UnificationXref
id: 4232221
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232221

UnificationXref2164
type: UnificationXref
id: 4233008
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233008

UnificationXref3691
type: UnificationXref
id: 4232223
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232223

UnificationXref2163
type: UnificationXref
id: REACT_2351
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2351.3

UnificationXref3692
type: UnificationXref
id: REACT_79367
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79367.9

UnificationXref2162
type: UnificationXref
id: 75973
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=75973

UnificationXref3693
type: UnificationXref
id: CHEBI:15430
db: ChEBI

UnificationXref2161
type: UnificationXref
id: REACT_81781
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81781.9

UnificationXref181
type: UnificationXref
id: REACT_2991
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2991.3

Catalysis112
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction135
control type: ACTIVATION
xref: RelationshipXref209
xref: RelationshipXref210
controller: RPE dimer (name copied from entity in Homo sapiens)

UnificationXref182
type: UnificationXref
id: CHEBI:17336
db: ChEBI

Catalysis111
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction134
control type: ACTIVATION
xref: RelationshipXref208
xref: RelationshipXref207
controller: PGD dimer (name copied from entity in Homo sapiens)

UnificationXref183
type: UnificationXref
id: 2473615
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2473615

Catalysis110
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction133
control type: ACTIVATION
xref: RelationshipXref206
xref: RelationshipXref205
controller: G6PD dimer and tetramer

http://identifiers.org/pubmed/20876572
type: PublicationXref
id: 20876572
author: Froese, D Sean
author: Ugochukwu, Emelie
author: Gileadi, Carina
author: Wu, Xuchu
author: Krysztofinska, Ewelina
author: Kochan, Grazyna
author: Yue, Wyatt W
author: Oppermann, U
author: Gravel, RA
author: Muniz, João R C
db: Pubmed
title: Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation
source: J. Biol. Chem. 285:38204-13
year: 2010

UnificationXref184
type: UnificationXref
id: REACT_161441
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161441.1

UnificationXref185
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Catalysis116
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction139
control type: ACTIVATION
xref: RelationshipXref214
xref: RelationshipXref213
controller: Note: the coordinates are copied over from Homo sapiens.

UnificationXref186
type: UnificationXref
id: 29366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29366

Catalysis115
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction138
control type: ACTIVATION
xref: RelationshipXref211
xref: RelationshipXref212
controller: Homologues of TALDO1

UnificationXref187
type: UnificationXref
id: REACT_4609
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4609.3

Catalysis114
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction137
control type: ACTIVATION
xref: RelationshipXref211
xref: RelationshipXref212
controller: Homologues of TALDO1

UnificationXref188
type: UnificationXref
id: P0AFP4
db: UniProt

Catalysis113
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction136
control type: ACTIVATION
xref: RelationshipXref209
xref: RelationshipXref210
controller: RPE dimer (name copied from entity in Homo sapiens)

UnificationXref189
type: UnificationXref
id: 4233264
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233264

Catalysis119
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction142
control type: ACTIVATION
xref: RelationshipXref216
xref: RelationshipXref218
controller: phosphoribosyl pyrophosphate synthetase holoenzyme

Catalysis118
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction141
control type: ACTIVATION
xref: RelationshipXref217
xref: RelationshipXref216
controller: phosphoribosyl pyrophosphate synthetase 1 holoenzyme (name copied from entity in Homo sapiens)

Catalysis117
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction140
control type: ACTIVATION
xref: RelationshipXref214
xref: RelationshipXref213
controller: Note: the coordinates are copied over from Homo sapiens.

UnificationXref3669
type: UnificationXref
id: 190157
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=190157

UnificationXref3667
type: UnificationXref
id: REACT_106757
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106757.9

UnificationXref2137
type: UnificationXref
id: 191324
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191324

UnificationXref3668
type: UnificationXref
id: CHEBI:28766
db: ChEBI

UnificationXref2136
type: UnificationXref
id: CHEBI:16057
db: ChEBI

http://identifiers.org/pubmed/9699462
type: PublicationXref
id: 9699462
author: Dierks, T
author: Selmer, T
author: von Figura, K
author: Schmidt, B
db: Pubmed
title: A novel protein modification generating an aldehyde group in sulfatases: its role in catalysis and disease
source: Bioessays 20:505-10
year: 1998

UnificationXref3665
type: UnificationXref
id: 4232227
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232227

UnificationXref2139
type: UnificationXref
id: Q46822
db: UniProt

UnificationXref3666
type: UnificationXref
id: 4232229
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232229

UnificationXref2138
type: UnificationXref
id: REACT_9855
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9855.2

UnificationXref3663
type: UnificationXref
id: P29680
db: UniProt

UnificationXref2133
type: UnificationXref
id: CHEBI:16584
db: ChEBI

UnificationXref3664
type: UnificationXref
id: 4232226
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232226

UnificationXref2132
type: UnificationXref
id: REACT_92117
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92117.9

http://identifiers.org/pubmed/19442142
type: PublicationXref
id: 19442142
author: Volpi, N
author: Schiller, J
author: Soltés, L
author: Stern, R
db: Pubmed
title: Role, metabolism, chemical modifications and applications of hyaluronan
source: Curr Med Chem 16:1718-45
year: 2009

http://identifiers.org/pubmed/12039040
type: PublicationXref
id: 12039040
author: Massacrier, A
author: Pereira, S
author: Cau, P
author: Szepetowski, P
author: Roll, P
author: Robaglia-Schlupp, A
db: Pubmed
title: New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions) families
source: Gene 285:141-8
year: 2002

UnificationXref3661
type: UnificationXref
id: 189455
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189455

UnificationXref2135
type: UnificationXref
id: REACT_9725
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9725.2

UnificationXref3662
type: UnificationXref
id: REACT_9699
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9699.3

UnificationXref2134
type: UnificationXref
id: 191362
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191362

UnificationXref3660
type: UnificationXref
id: CHEBI:15439
db: ChEBI

UnificationXref2131
type: UnificationXref
id: 4233357
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233357

UnificationXref2130
type: UnificationXref
id: REACT_93879
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93879.9

UnificationXref191
type: UnificationXref
id: REACT_162039
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_162039.2

UnificationXref190
type: UnificationXref
id: 4233266
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233266

UnificationXref194
type: UnificationXref
id: 4233547
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233547

UnificationXref195
type: UnificationXref
id: REACT_163572
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_163572.2

http://identifiers.org/pubmed/10448521
type: PublicationXref
id: 10448521
author: Seetharam, B
db: Pubmed
title: Receptor-mediated endocytosis of cobalamin (vitamin B12)
source: Annu. Rev. Nutr. 19:173-95
year: 1999

UnificationXref192
type: UnificationXref
id: 4233546
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233546

Catalysis101
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction120
control type: ACTIVATION
xref: RelationshipXref178
xref: RelationshipXref179
controller: phosphoglycerate mutase dimer

UnificationXref193
type: UnificationXref
id: REACT_163399
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_163399.2

Catalysis100
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction119
control type: ACTIVATION
xref: RelationshipXref180
xref: RelationshipXref181
controller: enolase 1 dimer, (alpha) (name copied from entity in Homo sapiens)

UnificationXref198
type: UnificationXref
id: P0AD61
db: UniProt

Catalysis103
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction122
control type: ACTIVATION
xref: RelationshipXref175
xref: RelationshipXref174
controller: triosephosphate isomerase dimer (name copied from entity in Homo sapiens)

UnificationXref199
type: UnificationXref
id: 4231736
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231736

Catalysis102
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction121
control type: ACTIVATION
xref: RelationshipXref176
xref: RelationshipXref177
controller: phosphoglycerate kinase 1 complex (name copied from entity in Homo sapiens)

UnificationXref196
type: UnificationXref
id: 4233475
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233475

Catalysis105
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction124
control type: ACTIVATION
xref: RelationshipXref193
xref: RelationshipXref194
controller: PGM1:Mg++ (name copied from entity in Homo sapiens)

UnificationXref197
type: UnificationXref
id: REACT_161597
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161597.2

Catalysis104
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction123
control type: ACTIVATION
xref: RelationshipXref171
xref: RelationshipXref170
controller: glucose 6-phosphate isomerase dimer (name copied from entity in Homo sapiens)

Catalysis107
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction130
control type: ACTIVATION
xref: RelationshipXref199
xref: RelationshipXref198
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis106
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction129
control type: ACTIVATION
xref: RelationshipXref193
xref: RelationshipXref194
controller: PGM1:Mg++ (name copied from entity in Homo sapiens)

Catalysis109
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction132
control type: ACTIVATION
xref: RelationshipXref203
xref: RelationshipXref202
controller: GALE dimer (name copied from entity in Homo sapiens)

Catalysis108
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction131
control type: ACTIVATION
xref: RelationshipXref201
xref: RelationshipXref200
controller: P09148

UnificationXref3676
type: UnificationXref
id: GO:0005758
db: GENE ONTOLOGY

UnificationXref3677
type: UnificationXref
id: 189461
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189461

UnificationXref2149
type: UnificationXref
id: CHEBI:16359
db: ChEBI

UnificationXref3678
type: UnificationXref
id: REACT_9648
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9648.2

UnificationXref2148
type: UnificationXref
id: REACT_10835
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10835.1

UnificationXref3679
type: UnificationXref
id: 189411
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189411

UnificationXref2147
type: UnificationXref
id: 192356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192356

UnificationXref3672
type: UnificationXref
id: 190128
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=190128

UnificationXref2146
type: UnificationXref
id: CHEBI:15519
db: ChEBI

UnificationXref3673
type: UnificationXref
id: REACT_9818
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9818.3

UnificationXref2145
type: UnificationXref
id: REACT_32659
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32659.10

UnificationXref3674
type: UnificationXref
id: 4232245
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232245

UnificationXref2144
type: UnificationXref
id: 4233420
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233420

UnificationXref3675
type: UnificationXref
id: REACT_93060
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93060.9

UnificationXref2143
type: UnificationXref
id: REACT_102787
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102787.9

UnificationXref2142
type: UnificationXref
id: 4232251
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232251

UnificationXref2141
type: UnificationXref
id: 4232249
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232249

UnificationXref3670
type: UnificationXref
id: REACT_9880
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9880.2

UnificationXref2140
type: UnificationXref
id: 4232248
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232248

UnificationXref3671
type: UnificationXref
id: CHEBI:28607
db: ChEBI

http://identifiers.org/pubmed/15084262
type: PublicationXref
id: 15084262
author: Edgar, BA
author: Reis, T
db: Pubmed
title: Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing
source: Cell 117:253-64
year: 2004

http://identifiers.org/pubmed/7564244
type: PublicationXref
id: 7564244
author: Mooyer, P
author: Wanders, RJ
db: Pubmed
title: D-2-hydroxyglutaric acidaemia: identification of a new enzyme, D-2-hydroxyglutarate dehydrogenase, localized in mitochondria
source: J Inherit Metab Dis 18:194-6
year: 1995

D-Glucuronate
type: SmallMoleculeReference
name: Glucuronate
name: D-Glucuronate [ChEBI:4178]
name: Glucuronic acid
xref: UnificationXref1290

RelationshipXref499
type: RelationshipXref
id: GO:0004647
db: GENE ONTOLOGY
relationship type: MI:0355

quinolinate(1-)
type: SmallMoleculeReference
name: ChEBI:46828 quinolinate(1-)
xref: UnificationXref3225

RelationshipXref498
type: RelationshipXref
id: 4232952
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232952

RelationshipXref497
type: RelationshipXref
id: GO:0004648
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref496
type: RelationshipXref
id: 4232958
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232958

RelationshipXref495
type: RelationshipXref
id: GO:0004617
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref494
type: RelationshipXref
id: 4231573
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231573

RelationshipXref493
type: RelationshipXref
id: GO:0004066
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref492
type: RelationshipXref
id: 4232732
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232732

RelationshipXref491
type: RelationshipXref
id: GO:0017084
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref490
type: RelationshipXref
id: GO:0006766
db: GENE ONTOLOGY
relationship type: MI:0359

UniProt:P52061
type: ProteinReference
xref: UnificationXref3135
organism: BioSource1

http://identifiers.org/pubmed/15924268
type: PublicationXref
id: 15924268
author: Nejsum, LN
db: Pubmed
title: The renal plumbing system: aquaporin water channels
source: Cell Mol Life Sci 62:1692-706
year: 2005

http://identifiers.org/pubmed/15249053
type: PublicationXref
id: 15249053
author: Schirch, V
author: di Salvo, ML
author: Hunt, S
db: Pubmed
title: Expression, purification, and kinetic constants for human and Escherichia coli pyridoxal kinases
source: Protein Expr Purif 36:300-6
year: 2004

http://identifiers.org/pubmed/1390320
type: PublicationXref
id: 1390320
author: Russell, DW
db: Pubmed
title: Cholesterol biosynthesis and metabolism
source: Cardiovasc Drugs Ther 6:103-10
year: 1992

http://identifiers.org/pubmed/16219661
type: PublicationXref
id: 16219661
author: Suzuki, Makoto
db: Pubmed
title: The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels
source: Exp. Physiol. 91:141-7
year: 2006

D-Fructose 2,6-bisphosphate [ChEBI:28602]
type: SmallMoleculeReference
name: D-Fructose 2,6-bisphosphate
xref: UnificationXref1471

Coproporphyrinogen I
type: SmallMoleculeReference
name: Coproporphyrinogen I [ChEBI:3879]
xref: UnificationXref3671

http://identifiers.org/pubmed/11952783
type: PublicationXref
id: 11952783
author: Kurachi, Y
author: Kishida, K
author: Matsuzawa, Y
author: Makino, Y
author: Matsuda, M
author: Kondo, H
author: Nakamura, T
author: Kuriyama, H
author: Nagaretani, H
author: Maeda, N
author: Nishizawa, H
author: Funahashi, T
author: Shimomura, I
author: Kihara, S
db: Pubmed
title: Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation
source: Eur J Biochem 269:1814-26
year: 2002

lysosomal lumen
type: CellularLocationVocabulary
xref: UnificationXref89

http://identifiers.org/pubmed/1574589
type: PublicationXref
id: 1574589
author: Dixon, JE
author: Zalkin, H
db: Pubmed
title: De novo purine nucleotide biosynthesis
source: Prog Nucleic Acid Res Mol Biol 42:259-287
year: 1992

http://identifiers.org/pubmed/7789985
type: PublicationXref
id: 7789985
author: Spinner, NB
author: Kwon, HM
author: Mallee, JJ
author: Mulla, WR
author: Muenke, M
author: Berry, GT
author: Rim, JS
db: Pubmed
title: The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21
source: Genomics 25:507-13
year: 1995

http://identifiers.org/pubmed/16539657
type: PublicationXref
id: 16539657
author: Kakiuchi, C
author: Hayashi, A
author: Ishiwata, M
author: Kato, T
db: Pubmed
title: XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells
source: J Neurochem 97:545-55
year: 2006

http://identifiers.org/pubmed/11306702
type: PublicationXref
id: 11306702
author: Karlsson, A
author: Norda, A
author: Linden, K
author: Johansson, M
author: Van Rompay, AR
db: Pubmed
title: Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases
source: Mol Pharmacol 59:1181-1186
year: 2001

http://identifiers.org/pubmed/8101838
type: PublicationXref
id: 8101838
author: North, RA
author: Amara, SG
author: Murdoch, GH
author: Fairman, WA
author: Arriza, JL
author: Wu, YN
author: Kavanaugh, MP
db: Pubmed
title: Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family
source: J Biol Chem 268:15329-32
year: 1993

http://identifiers.org/pubmed/10764807
type: PublicationXref
id: 10764807
author: Takeuchi, N
author: Shimada, N
author: Nishikawa, K
author: Yokogawa, T
author: Watanabe, K
author: Suzuki, T
author: Ueda, T
author: Benkowski, L
author: Spremulli, LL
author: Omori, A
db: Pubmed
title: Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase
source: J Biol Chem 275:19913-20
year: 2000

http://identifiers.org/pubmed/8464497
type: PublicationXref
id: 8464497
author: Booth, DR
author: Totty, N
author: Pepys, MB
author: Blake, CC
author: Hawkins, PN
author: Terry, CJ
author: Tennent, GA
author: Vigushin, DM
author: Nguyen, O
author: Soutar, AK
db: Pubmed
title: Human lysozyme gene mutations cause hereditary systemic amyloidosis
source: Nature 362:553-7
year: 1993

Post-translational protein modification
type: Pathway
data source: Provenance1
pathway component: REACT 159083.3
pathway component: Asparagine N-linked glycosylation
evidence: Evidence156
xref: UnificationXref1113
xref: RelationshipXref124
xref: UnificationXref1114
pathway order: PathwayStep147
pathway order: PathwayStep142
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3612
type: UnificationXref
id: 1614594
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614594

UnificationXref3613
type: UnificationXref
id: REACT_117652
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117652.1

UnificationXref3610
type: UnificationXref
id: REACT_145476
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145476.5

eNOS activation and regulation
type: Pathway
data source: Provenance1
pathway component: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
evidence: Evidence396
xref: UnificationXref2560
xref: RelationshipXref342
xref: UnificationXref2559
pathway order: PathwayStep382
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3611
type: UnificationXref
id: CHEBI:62856
db: ChEBI

RelationshipXref450
type: RelationshipXref
id: GO:0008478
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite227
type: SequenceSite
position status: EQUAL
sequence position: 477

http://identifiers.org/pubmed/10884394
type: PublicationXref
id: 10884394
author: Thelander, L
author: Reichard, P
author: Eliasson, R
author: Ingemarson, R
db: Pubmed
title: Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase
source: J Biol Chem 275:33021-33026
year: 2000

RelationshipXref451
type: RelationshipXref
id: 4232913
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232913

SequenceSite226
type: SequenceSite
position status: EQUAL
sequence position: 15

http://identifiers.org/pubmed/19300440
type: PublicationXref
id: 19300440
author: Kim, YG
author: Park, BJ
author: Lee, S
author: Kwon, OS
author: Kim, KJ
author: Lee, SJ
author: Park, SY
db: Pubmed
title: Redox-switch modulation of human SSADH by dynamic catalytic loop
source: EMBO J 28:959-68
year: 2009

SequenceSite229
type: SequenceSite
position status: EQUAL
sequence position: 645

SequenceSite228
type: SequenceSite
position status: EQUAL
sequence position: 48

http://identifiers.org/pubmed/8257433
type: PublicationXref
id: 8257433
author: Hopkinson, DA
author: Edwards, YH
author: Whitehouse, DB
author: Ives, JH
author: Hollyoake, M
author: Putt, W
db: Pubmed
title: Phosphoglucomutase 1: a gene with two promoters and a duplicated first exon
source: Biochem J 296:417-22
year: 1993

RelationshipXref458
type: RelationshipXref
id: 4232272
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232272

RelationshipXref459
type: RelationshipXref
id: GO:0003951
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref3619
type: UnificationXref
id: REACT_117648
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117648.1

RelationshipXref456
type: RelationshipXref
id: GO:0006768
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite221
type: SequenceSite
position status: EQUAL
sequence position: 154

UnificationXref3618
type: UnificationXref
id: 1614582
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614582

RelationshipXref457
type: RelationshipXref
id: GO:0004514
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite220
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref3617
type: UnificationXref
id: CHEBI:21347
db: ChEBI

RelationshipXref454
type: RelationshipXref
id: GO:0042816
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite223
type: SequenceSite
position status: EQUAL
sequence position: 154

UnificationXref3616
type: UnificationXref
id: 4233131
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233131

RelationshipXref455
type: RelationshipXref
id: GO:0009235
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite222
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref3615
type: UnificationXref
id: REACT_128699
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128699.5

RelationshipXref452
type: RelationshipXref
id: GO:0004733
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite225
type: SequenceSite
position status: EQUAL
sequence position: 528

UnificationXref3614
type: UnificationXref
id: 4233130
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233130

RelationshipXref453
type: RelationshipXref
id: 4232921
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232921

SequenceSite224
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref3600
type: UnificationXref
id: REACT_137414
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137414.5

UnificationXref3601
type: UnificationXref
id: CHEBI:17230
db: ChEBI

UnificationXref3602
type: UnificationXref
id: 174369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174369

http://identifiers.org/pubmed/8186247
type: PublicationXref
id: 8186247
author: Ofman, R
author: Wanders, RJ
db: Pubmed
title: Purification of peroxisomal acyl-CoA: dihydroxyacetonephosphate acyltransferase from human placenta
source: Biochim Biophys Acta 1206:27-34
year: 1994

RelationshipXref460
type: RelationshipXref
id: 4232267
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232267

SequenceSite239
type: SequenceSite
position status: EQUAL
sequence position: 518

RelationshipXref461
type: RelationshipXref
id: GO:0008936
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite238
type: SequenceSite
position status: EQUAL
sequence position: 35

RelationshipXref462
type: RelationshipXref
id: 197229
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197229

SequenceSite237
type: SequenceSite
position status: EQUAL
sequence position: 475

UnificationXref3608
type: UnificationXref
id: REACT_145721
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145721.5

RelationshipXref467
type: RelationshipXref
id: GO:0004326
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite232
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref3607
type: UnificationXref
id: 4233139
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233139

RelationshipXref468
type: RelationshipXref
id: 4232277
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232277

SequenceSite231
type: SequenceSite
position status: EQUAL
sequence position: 523

RelationshipXref469
type: RelationshipXref
id: GO:0004329
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite230
type: SequenceSite
position status: EQUAL
sequence position: 42

UnificationXref3609
type: UnificationXref
id: 4233137
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233137

UnificationXref3604
type: UnificationXref
id: CHEBI:16136
db: ChEBI

RelationshipXref463
type: RelationshipXref
id: GO:0006769
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite236
type: SequenceSite
position status: EQUAL
sequence position: 30

http://identifiers.org/pubmed/18664523
type: PublicationXref
id: 18664523
author: Yamamoto, K
author: Kaufman, RJ
author: Suzuki, N
author: Yoshida, H
author: Mori, K
author: Okada, T
author: Wada, T
db: Pubmed
title: Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds
source: J Biochem 144:477-86
year: 2008

UnificationXref3603
type: UnificationXref
id: REACT_7731
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7731.2

RelationshipXref464
type: RelationshipXref
id: GO:0019674
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite235
type: SequenceSite
position status: EQUAL
sequence position: 1012

http://identifiers.org/pubmed/8812490
type: PublicationXref
id: 8812490
author: Kuo, WL
author: Ma, T
author: Yang, B
author: Verkman, AS
db: Pubmed
title: cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13
source: Genomics 35:543-50
year: 1996

UnificationXref3606
type: UnificationXref
id: REACT_116358
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116358.1

RelationshipXref465
type: RelationshipXref
id: GO:0033560
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite234
type: SequenceSite
position status: EQUAL
sequence position: 49

UnificationXref3605
type: UnificationXref
id: 1614532
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614532

RelationshipXref466
type: RelationshipXref
id: 4232283
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232283

SequenceSite233
type: SequenceSite
position status: EQUAL
sequence position: 775

SequenceSite209
type: SequenceSite
position status: EQUAL
sequence position: 498

SequenceSite208
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref472
type: RelationshipXref
id: 4232293
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232293

SequenceSite205
type: SequenceSite
position status: EQUAL
sequence position: 498

RelationshipXref473
type: RelationshipXref
id: GO:0004486
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite204
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref470
type: RelationshipXref
id: 4232303
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232303

SequenceSite207
type: SequenceSite
position status: EQUAL
sequence position: 498

RelationshipXref471
type: RelationshipXref
id: GO:0004477
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite206
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref476
type: RelationshipXref
id: 4232299
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232299

SequenceSite201
type: SequenceSite
position status: EQUAL
sequence position: 420

RelationshipXref477
type: RelationshipXref
id: GO:0046655
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite200
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref474
type: RelationshipXref
id: 4232291
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232291

SequenceSite203
type: SequenceSite
position status: EQUAL
sequence position: 420

RelationshipXref475
type: RelationshipXref
id: GO:0004489
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite202
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref478
type: RelationshipXref
id: GO:0070283
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref479
type: RelationshipXref
id: 4232885
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232885

UnificationXref2099
type: UnificationXref
id: 4233448
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233448

UniProt:P76217
type: ProteinReference
xref: UnificationXref3462
organism: BioSource1

UnificationXref2094
type: UnificationXref
id: REACT_17364
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17364.2

UnificationXref2093
type: UnificationXref
id: 390394
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390394

UnificationXref2092
type: UnificationXref
id: CHEBI:52966
db: ChEBI

http://identifiers.org/pubmed/19648010
type: PublicationXref
id: 19648010
author: Liu, C
author: Kang, JS
author: Derynck, R
db: Pubmed
title: New regulatory mechanisms of TGF-beta receptor function
source: Trends Cell Biol 19:385-94
year: 2009

UnificationXref2091
type: UnificationXref
id: REACT_33669
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33669.10

UnificationXref2098
type: UnificationXref
id: REACT_84586
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_84586.9

UnificationXref2097
type: UnificationXref
id: 4232492
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232492

UnificationXref2096
type: UnificationXref
id: REACT_17913
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17913.2

UnificationXref2095
type: UnificationXref
id: 390260
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390260

RelationshipXref480
type: RelationshipXref
id: GO:0031071
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite219
type: SequenceSite
position status: EQUAL
sequence position: 105

RelationshipXref481
type: RelationshipXref
id: 4232871
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232871

SequenceSite218
type: SequenceSite
position status: EQUAL
sequence position: 2

RelationshipXref482
type: RelationshipXref
id: GO:0016783
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite217
type: SequenceSite
position status: EQUAL
sequence position: 35

RelationshipXref483
type: RelationshipXref
id: 4232893
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232893

SequenceSite216
type: SequenceSite
position status: EQUAL
sequence position: 32

UniProt:P42589
type: ProteinReference
xref: UnificationXref822
organism: BioSource1

RelationshipXref484
type: RelationshipXref
id: GO:0030366
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite215
type: SequenceSite
position status: EQUAL
sequence position: 105

RelationshipXref485
type: RelationshipXref
id: 4232898
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232898

SequenceSite214
type: SequenceSite
position status: EQUAL
sequence position: 2

RelationshipXref486
type: RelationshipXref
id: GO:0016740
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite213
type: SequenceSite
position status: EQUAL
sequence position: 1177

RelationshipXref487
type: RelationshipXref
id: 4232878
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232878

SequenceSite212
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref488
type: RelationshipXref
id: GO:0032324
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite211
type: SequenceSite
position status: EQUAL
sequence position: 498

RelationshipXref489
type: RelationshipXref
id: GO:0006767
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite210
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref413
type: RelationshipXref
id: GO:0004799
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite264
type: SequenceSite
position status: EQUAL
sequence position: 25

RelationshipXref412
type: RelationshipXref
id: 4231827
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231827

SequenceSite265
type: SequenceSite
position status: EQUAL
sequence position: 566

RelationshipXref415
type: RelationshipXref
id: GO:0046134
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite262
type: SequenceSite
position status: EQUAL
sequence position: 25

RelationshipXref414
type: RelationshipXref
id: 4231813
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231813

SequenceSite263
type: SequenceSite
position status: EQUAL
sequence position: 566

SequenceSite268
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite269
type: SequenceSite
position status: EQUAL
sequence position: 223

RelationshipXref411
type: RelationshipXref
id: GO:0004170
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite266
type: SequenceSite
position status: EQUAL
sequence position: 22

RelationshipXref410
type: RelationshipXref
id: 4231773
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231773

SequenceSite267
type: SequenceSite
position status: EQUAL
sequence position: 803

http://identifiers.org/pubmed/18173545
type: PublicationXref
id: 18173545
author: Calamita, G
author: Svelto, M
author: Portincasa, P
author: Palasciano, G
db: Pubmed
title: Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease
source: Eur J Clin Invest 38:1-10
year: 2008

http://identifiers.org/pubmed/18566824
type: PublicationXref
id: 18566824
author: Takata, K
author: Tajika, Y
author: Hasegawa, T
author: Matsuzaki, T
author: Ablimit, A
db: Pubmed
title: Localization and trafficking of aquaporin 2 in the kidney
source: Histochem Cell Biol 130:197-209
year: 2008

UnificationXref1519
type: UnificationXref
id: P0A6P9
db: UniProt

UnificationXref1517
type: UnificationXref
id: 29492
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29492

UnificationXref1518
type: UnificationXref
id: REACT_5622
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5622.2

UnificationXref1515
type: UnificationXref
id: REACT_115355
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115355.8

UnificationXref1516
type: UnificationXref
id: CHEBI:18021
db: ChEBI

UnificationXref1513
type: UnificationXref
id: 4231701
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231701

UnificationXref1514
type: UnificationXref
id: 4231730
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231730

UnificationXref1512
type: UnificationXref
id: 4231700
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231700

UnificationXref1511
type: UnificationXref
id: 4231699
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231699

ChEBI:17732 Ala-tRNA(Ala)
type: SmallMoleculeReference
name: Ala-tRNA(Ala)
xref: UnificationXref983

UnificationXref1510
type: UnificationXref
id: 4231698
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231698

Base Excision Repair
type: Pathway
data source: Provenance1
pathway component: REACT 93955.9
evidence: Evidence51
xref: RelationshipXref28
xref: UnificationXref349
xref: UnificationXref348
pathway order: PathwayStep45
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref416
type: RelationshipXref
id: GO:0016763
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite261
type: SequenceSite
position status: EQUAL
sequence position: 566

RelationshipXref417
type: RelationshipXref
id: 4232145
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232145

SequenceSite260
type: SequenceSite
position status: EQUAL
sequence position: 25

RelationshipXref418
type: RelationshipXref
id: GO:0019206
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref419
type: RelationshipXref
id: 4231807
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231807

RelationshipXref426
type: RelationshipXref
id: GO:0046135
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite273
type: SequenceSite
position status: EQUAL
sequence position: 328

http://identifiers.org/pubmed/10581036
type: PublicationXref
id: 10581036
author: Joosse, M
author: Verbeek, E
author: Mancini, GM
author: Peltonen, L
author: Galjaard, H
author: Havelaar, AC
author: Aula, P
author: van der Spek, PJ
author: Beerens, CE
author: Aula, N
author: Verheijen, FW
db: Pubmed
title: A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases
source: Nat Genet 23:462-5
year: 1999

RelationshipXref425
type: RelationshipXref
id: 4231801
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231801

SequenceSite274
type: SequenceSite
position status: EQUAL
sequence position: 17

RelationshipXref424
type: RelationshipXref
id: GO:0004157
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite275
type: SequenceSite
position status: EQUAL
sequence position: 669

RelationshipXref423
type: RelationshipXref
id: 4231795
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231795

SequenceSite276
type: SequenceSite
position status: EQUAL
sequence position: 17

RelationshipXref422
type: RelationshipXref
id: GO:0017113
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite277
type: SequenceSite
position status: EQUAL
sequence position: 669

RelationshipXref421
type: RelationshipXref
id: GO:0043097
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite278
type: SequenceSite
position status: EQUAL
sequence position: 15

RelationshipXref420
type: RelationshipXref
id: 4232040
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232040

SequenceSite279
type: SequenceSite
position status: EQUAL
sequence position: 602

L-Leucine
type: SmallMoleculeReference
name: (2S)-alpha-2-Amino-4-methylvaleric acid
name: L-Leucine [ChEBI:15603]
name: (2S)-alpha-Leucine
name: 2-amino-4-methylvaleric acid
xref: UnificationXref902

UnificationXref1506
type: UnificationXref
id: 30485
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30485

UnificationXref1507
type: UnificationXref
id: REACT_3473
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3473.2

UnificationXref1508
type: UnificationXref
id: P62707
db: UniProt

UnificationXref1509
type: UnificationXref
id: 4231697
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231697

UnificationXref1502
type: UnificationXref
id: 4231512
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231512

UnificationXref1503
type: UnificationXref
id: 4231768
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231768

Deoxythymidine
type: SmallMoleculeReference
name: Thymidine [ChEBI:17748]
name: Thymidine
xref: UnificationXref565

UnificationXref1504
type: UnificationXref
id: REACT_154866
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154866.3

UnificationXref1505
type: UnificationXref
id: CHEBI:17835
db: ChEBI

UnificationXref1501
type: UnificationXref
id: 4231511
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231511

3-decaprenyl-4-hydroxybenzoic acid
type: SmallMoleculeReference
name: 3-decaprenyl-4-hydroxybenzoic acid [ChEBI:64136]
xref: UnificationXref2458

Sphingolipid metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 129989.5
evidence: Evidence381
xref: UnificationXref2450
xref: UnificationXref2451
xref: RelationshipXref323
pathway order: PathwayStep367
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1500
type: UnificationXref
id: P0A799
db: UniProt

RelationshipXref429
type: RelationshipXref
id: 4232046
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232046

SequenceSite270
type: SequenceSite
position status: EQUAL
sequence position: 2

RelationshipXref427
type: RelationshipXref
id: GO:0006206
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite272
type: SequenceSite
position status: EQUAL
sequence position: 2

RelationshipXref428
type: RelationshipXref
id: GO:0004017
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite271
type: SequenceSite
position status: EQUAL
sequence position: 561

RelationshipXref431
type: RelationshipXref
id: 4231832
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231832

SequenceSite246
type: SequenceSite
position status: EQUAL
sequence position: 25

RelationshipXref430
type: RelationshipXref
id: GO:0004385
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite247
type: SequenceSite
position status: EQUAL
sequence position: 566

RelationshipXref433
type: RelationshipXref
id: 4232123
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232123

SequenceSite244
type: SequenceSite
position status: EQUAL
sequence position: 2

RelationshipXref432
type: RelationshipXref
id: GO:0036175
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite245
type: SequenceSite
position status: EQUAL
sequence position: 423

RelationshipXref435
type: RelationshipXref
id: 4232135
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232135

SequenceSite242
type: SequenceSite
position status: EQUAL
sequence position: 17

RelationshipXref434
type: RelationshipXref
id: GO:0004748
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite243
type: SequenceSite
position status: EQUAL
sequence position: 477

RelationshipXref437
type: RelationshipXref
id: 4231756
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231756

SequenceSite240
type: SequenceSite
position status: EQUAL
sequence position: 19

http://identifiers.org/pubmed/12369887
type: PublicationXref
id: 12369887
author: Danielson, PB
db: Pubmed
title: The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans
source: Curr Drug Metab 3:561-97
year: 2002

RelationshipXref436
type: RelationshipXref
id: GO:0004362
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite241
type: SequenceSite
position status: EQUAL
sequence position: 360

SequenceSite248
type: SequenceSite
position status: EQUAL
sequence position: 25

SequenceSite249
type: SequenceSite
position status: EQUAL
sequence position: 566

http://identifiers.org/pubmed/10692433
type: PublicationXref
id: 10692433
author: Kijima, S
author: Fujita, M
author: Arata, Y
author: Ohtani, K
author: Kato, JY
db: Pubmed
title: Cdk2-dependent and -independent pathways in E2F-mediated S phase induction
source: J Biol Chem 275:6337-45
year: 2000

1,2,3-Propanetriol
type: SmallMoleculeReference
name: Glycerol
name: Glycerol [ChEBI:17754]
name: Glycerin
name: 1,2,3-Trihydroxypropane
xref: UnificationXref695

http://identifiers.org/pubmed/3932573
type: PublicationXref
id: 3932573
author: Kuhl, W
author: Beutler, E
db: Pubmed
title: Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism
source: J Lab Clin Med 106:573-7
year: 1985

RelationshipXref438
type: RelationshipXref
id: GO:0015949
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref439
type: RelationshipXref
id: GO:0036220
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/15070399
type: PublicationXref
id: 15070399
author: Rider, MH
author: Vertommen, D
author: Veiga-da-Cunha, M
author: Achouri, Y
author: Van Schaftingen, E
author: Noel, G
db: Pubmed
title: Identification of a dehydrogenase acting on D-2-hydroxyglutarate
source: Biochem J 381:35-42
year: 2004

RelationshipXref444
type: RelationshipXref
id: 4233274
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233274

SequenceSite255
type: SequenceSite
position status: EQUAL
sequence position: 566

http://identifiers.org/pubmed/1697585
type: PublicationXref
id: 1697585
author: Wacker, H
author: Galand, G
author: Mantei, N
author: Ruf, J
author: von Kieckebusch, A
author: James, P
author: Maffia, M
author: Seiler, P
author: Semenza, G
db: Pubmed
title: Rabbit small intestinal trehalase. Purification, cDNA cloning, expression, and verification of glycosylphosphatidylinositol anchoring.
source: J Biol Chem 265:15034-9
year: 1990

RelationshipXref443
type: RelationshipXref
id: GO:0036222
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite256
type: SequenceSite
position status: EQUAL
sequence position: 25

RelationshipXref442
type: RelationshipXref
id: 4233277
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233277

SequenceSite257
type: SequenceSite
position status: EQUAL
sequence position: 566

http://identifiers.org/pubmed/1894595
type: PublicationXref
id: 1894595
author: Burbaum, JJ
author: Schimmel, P
db: Pubmed
title: Structural relationships and the classification of aminoacyl-tRNA synthetases
source: J Biol Chem 266:16965-8
year: 1991

RelationshipXref441
type: RelationshipXref
id: GO:0035870
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite258
type: SequenceSite
position status: EQUAL
sequence position: 25

RelationshipXref448
type: RelationshipXref
id: GO:0009108
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite251
type: SequenceSite
position status: EQUAL
sequence position: 566

RelationshipXref447
type: RelationshipXref
id: 4232261
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232261

SequenceSite252
type: SequenceSite
position status: EQUAL
sequence position: 25

RelationshipXref446
type: RelationshipXref
id: GO:0004633
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite253
type: SequenceSite
position status: EQUAL
sequence position: 566

RelationshipXref445
type: RelationshipXref
id: GO:0055086
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite254
type: SequenceSite
position status: EQUAL
sequence position: 25

http://identifiers.org/pubmed/10656833
type: PublicationXref
id: 10656833
author: Arvai, AS
author: Tainer, JA
author: Putnam, CD
author: Bourne, Y
db: Pubmed
title: Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.
source: J Mol Biol 296:295-309
year: 2000

15-Hydroperoxyicosatetraenoic acid
type: SmallMoleculeReference
name: 15-Hydroperoxyicosatetraenoate
name: (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
name: 15-Hydroperoxyeicosatetraenoate
name: 15-HPETE
name: 15-Hydroperoxyeicosatetraenoic acid
name: 15-HPETE [ChEBI:758]
xref: UnificationXref2361

(5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
type: SmallMoleculeReference
name: S-Adenosyl-L-methioninamine
name: S-Adenosylmethioninamine [ChEBI:8947]
name: S-Adenosylmethioninamine
xref: UnificationXref3532

RelationshipXref440
type: RelationshipXref
id: 4233271
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233271

SequenceSite259
type: SequenceSite
position status: EQUAL
sequence position: 566

(5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyicosa-5,8,10,14-tetraenoate
type: SmallMoleculeReference
name: (5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyeicosa-5,8,10,14-tetraenoate [ChEBI:250]
name: (5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyeicosa-5,8,10,14-tetraenoate
xref: UnificationXref2382

carbovir monophosphate [ChEBI:64116]
type: SmallMoleculeReference
name: carbovir monophosphate
xref: UnificationXref3878

http://identifiers.org/pubmed/10692424
type: PublicationXref
id: 10692424
author: van den Bosch, H
author: Fraaije, MW
author: Hilkes, YH
author: de Vet, EC
db: Pubmed
title: Alkyl-dihydroxyacetonephosphate synthase. Presence and role of flavin adenine dinucleotide
source: J Biol Chem 275:6276-83
year: 2000

abacavir monophosphate [ChEBI:64112]
type: SmallMoleculeReference
name: abacavir monophosphate
xref: UnificationXref3872

http://identifiers.org/pubmed/11607846
type: PublicationXref
id: 11607846
author: Inohara, N
author: Nunez, G
db: Pubmed
title: The NOD: a signaling module that regulates apoptosis and host defense against pathogens
source: Oncogene 20:6473-81
year: 2001

RelationshipXref449
type: RelationshipXref
id: GO:0015939
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite250
type: SequenceSite
position status: EQUAL
sequence position: 25

5,6,7,8-Tetrahydrofolate
type: SmallMoleculeReference
name: Tetrahydrofolate
name: Tetrahydrofolate [ChEBI:15635]
name: THF
name: Tetrahydrofolic acid
xref: UnificationXref2687

10-Formyl-THF
type: SmallMoleculeReference
name: 10-Formyltetrahydrofolate [ChEBI:15637]
name: 10-Formyltetrahydrofolate
xref: UnificationXref2681

http://identifiers.org/pubmed/21173190
type: PublicationXref
id: 21173190
author: Agarwal, AK
author: Prasad, SS
author: Garg, A
db: Pubmed
title: Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria
source: J Lipid Res 52:451-62
year: 2011

Synthesis of Lipoxins (LX)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction198
pathway component: BiochemicalReaction197
evidence: Evidence375
xref: UnificationXref2405
xref: UnificationXref2406
xref: RelationshipXref316
pathway order: PathwayStep360
pathway order: PathwayStep361
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1559
type: UnificationXref
id: P24182
db: UniProt

UnificationXref1558
type: UnificationXref
id: REACT_5781
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5781.2

UnificationXref1557
type: UnificationXref
id: 113548
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113548

http://identifiers.org/pubmed/11001057
type: PublicationXref
id: 11001057
author: Rosenmund, C
author: Takamori, S
author: Rhee, JS
author: Jahn, R
db: Pubmed
title: Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons
source: Nature 407:189-94
year: 2000

http://identifiers.org/pubmed/8443237
type: PublicationXref
id: 8443237
author: Nilsson, A
author: Chen, Q
db: Pubmed
title: Desaturation and chain elongation of n - 3 and n - 6 polyunsaturated fatty acids in the human CaCo-2 cell line
source: Biochim Biophys Acta 1166:193-201
year: 1993

PublicationXref840
type: PublicationXref
id: 0781721458
author: Marks, AL
author: Smith, C
author: Lieberman, M
db: ISBN
title: Pathways of Sugar Metabolism
source: Basic Medical Biochemistry: A Clinical Approach, 2nd ed (Book): 527
year: 2005

UnificationXref1555
type: UnificationXref
id: 113581
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113581

UnificationXref1556
type: UnificationXref
id: REACT_4478
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4478.1

Urate [ChEBI:17775]
type: SmallMoleculeReference
name: Uric acid
name: Urate
xref: UnificationXref749

UnificationXref1553
type: UnificationXref
id: 113587
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113587

UnificationXref1554
type: UnificationXref
id: REACT_5253
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5253.2

UnificationXref1551
type: UnificationXref
id: REACT_4060
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4060.2

UnificationXref1552
type: UnificationXref
id: CHEBI:30744
db: ChEBI

5-HPETE
type: SmallMoleculeReference
name: 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
name: 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate [ChEBI:2061]
name: (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
xref: UnificationXref2339

Dihydrofolate [ChEBI:15633]
type: SmallMoleculeReference
name: dihydrofolic acid
name: 7,8-Dihydrofolic acid
name: Dihydrofolic acid
name: Dihydrofolate
name: 7,8-Dihydrofolate
xref: UnificationXref2948

UnificationXref1550
type: UnificationXref
id: 113557
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113557

Leukotriene B4
type: SmallMoleculeReference
name: (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate
name: Leukotriene B4 [ChEBI:6421]
name: (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyicosa-6,8,10,14-tetraenoate
xref: UnificationXref2308

UnificationXref1547
type: UnificationXref
id: CHEBI:16526
db: ChEBI

UnificationXref1546
type: UnificationXref
id: REACT_91535
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91535.9

UnificationXref1549
type: UnificationXref
id: REACT_2572
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2572.1

http://identifiers.org/pubmed/8167409
type: PublicationXref
id: 8167409
author: McMahon, Jill A
author: Smolich, Beverly D
author: McMahon, Andrew P
author: Papkoff, Jackie
db: Pubmed
title: Wnt family proteins are secreted and associated with the cell surface
source: Mol. Biol. Cell 4:1267-75
year: 1993

UnificationXref1548
type: UnificationXref
id: 29376
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29376

http://identifiers.org/pubmed/3143362
type: PublicationXref
id: 3143362
author: Sakuraba, H
author: Nagao, Y
author: Suzuki, Y
author: Tsuji, A
author: Oshima, A
db: Pubmed
title: Cloning, sequencing, and expression of cDNA for human beta-galactosidase
source: Biochem. Biophys. Res. Commun. 157:238-44
year: 1988

http://identifiers.org/pubmed/9108121
type: PublicationXref
id: 9108121
author: Eliasof, S
author: Amara, SG
author: Arriza, JL
author: Kavanaugh, MP
db: Pubmed
title: Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance
source: Proc Natl Acad Sci U S A 94:4155-60
year: 1997

http://identifiers.org/pubmed/10980531
type: PublicationXref
id: 10980531
author: de Koning, TJ
author: Babovic-Vuksanovic, D
author: Matthijs, G
author: Huijmans, JG
author: Dorland, L
author: Van Diggelen, OP
author: Freeze, H
author: Pronicka, E
author: Schollen, E
author: Winchester, B
author: Imtiaz, F
author: Marquardt, T
author: Patterson, M
author: Adamowicz, M
db: Pubmed
title: Genomic organization of the human phosphomannose isomerase (MPI) gene and mutation analysis in patients with congenital disorders of glycosylation type Ib (CDG-Ib)
source: Hum Mutat 16:247-52
year: 2000

http://identifiers.org/pubmed/8411712
type: PublicationXref
id: 8411712
author: Kamijo, K
author: Osumi, T
author: Hashimoto, T
db: Pubmed
title: PMP70, the 70-kDa peroxisomal membrane protein: a member of the ATP-binding cassette transporters
source: Nippon Rinsho 51:2343-52
year: 1993

UnificationXref1542
type: UnificationXref
id: 76183
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76183

http://identifiers.org/pubmed/1505961
type: PublicationXref
id: 1505961
author: Morris, C P
author: Hopwood, J J
author: Scott, H S
author: Guo, X H
db: Pubmed
title: Structure and sequence of the human alpha-L-iduronidase gene
source: Genomics 13:1311-3
year: 1992

UnificationXref1543
type: UnificationXref
id: REACT_2630
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2630.2

UnificationXref1544
type: UnificationXref
id: 4231742
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231742

UnificationXref1545
type: UnificationXref
id: 4233316
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233316

5-Methyltetrahydrofolate
type: SmallMoleculeReference
name: 5-Methyltetrahydrofolate [ChEBI:15641]
xref: UnificationXref3270

UnificationXref1540
type: UnificationXref
id: 4231743
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231743

http://identifiers.org/pubmed/20301244
type: PublicationXref
id: 20301244
author: Freeze, HH
author: Cummings, RD
author: Varki, A
author: Bertozzi, CR
author: Etzler, ME
author: Schachter, H
author: Stanley, P
author: Esko, JD
author: Hart, GW
author: Taniguchi, N
db: Pubmed
title: N-Glycans
year: 2009

PublicationXref835
type: PublicationXref
id: 9780849387326
author: Clarke, CF
author: Jonassen, T
db: ISBN
title: Genetic Analysis of Coenzyme Q Biosynthesis
source: Coenzyme Q: Molecular Mechanisms in Health and Disease (Book): 185-208
year: 2000

UnificationXref1541
type: UnificationXref
id: CHEBI:15351
db: ChEBI

UnificationXref1538
type: UnificationXref
id: 29358
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29358

http://identifiers.org/pubmed/3049610
type: PublicationXref
id: 3049610
author: Smith, BL
author: Agre, P
author: Denker, BM
author: Kuhajda, FP
db: Pubmed
title: Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules
source: J Biol Chem 263:15634-42
year: 1988

UnificationXref1537
type: UnificationXref
id: 4231741
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231741

UnificationXref1536
type: UnificationXref
id: REACT_3751
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3751.1

UnificationXref1535
type: UnificationXref
id: 30389
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30389

Methionine salvage pathway
type: Pathway
data source: Provenance1
pathway component: Transamination of MOB to methionine
evidence: Evidence538
xref: UnificationXref3556
xref: RelationshipXref529
xref: UnificationXref3555
pathway order: PathwayStep525
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1539
type: UnificationXref
id: REACT_5903
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5903.1

http://identifiers.org/pubmed/17478680
type: PublicationXref
id: 17478680
author: McMahon, HT
author: Kozlov, MM
author: Martens, S
db: Pubmed
title: How synaptotagmin promotes membrane fusion
source: Science 316:1205-8
year: 2007

SequenceSite289
type: SequenceSite
position status: EQUAL
sequence position: 389

SequenceSite288
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite287
type: SequenceSite
position status: EQUAL
sequence position: 187

SequenceSite286
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite285
type: SequenceSite
position status: EQUAL
sequence position: 535

SequenceSite284
type: SequenceSite
position status: EQUAL
sequence position: 48

SequenceSite282
type: SequenceSite
position status: EQUAL
sequence position: 29

SequenceSite283
type: SequenceSite
position status: EQUAL
sequence position: 500

SequenceSite280
type: SequenceSite
position status: EQUAL
sequence position: 15

SequenceSite281
type: SequenceSite
position status: EQUAL
sequence position: 602

http://identifiers.org/pubmed/17496910
type: PublicationXref
id: 17496910
author: McKay, MM
author: Morrison, DK
db: Pubmed
title: Integrating signals from RTKs to ERK/MAPK
source: Oncogene 26:3113-21
year: 2007

http://identifiers.org/pubmed/20301232
type: PublicationXref
id: 20301232
author: Freeze, HH
author: Cummings, RD
author: Varki, A
author: Bertozzi, CR
author: Etzler, ME
author: Schachter, H
author: Brockhausen, I
author: Stanley, P
author: Esko, JD
author: Hart, GW
db: Pubmed
title: O-GalNAc Glycans
year: 2009

XMP
type: SmallMoleculeReference
name: xanthosine 5'-monophosphate
name: Xanthylic acid
name: xanthosine 5'-monophosphate [ChEBI:15652]
name: (9-D-Ribosylxanthine)-5'-phosphate
xref: UnificationXref2730

http://identifiers.org/pubmed/9630604
type: PublicationXref
id: 9630604
author: Li, X
author: Hiratsuka, M
author: Suzuki, Y
author: Sakamoto, O
author: Narisawa, K
author: Aoki, Y
db: Pubmed
title: Identification of holocarboxylase synthetase (HCS) proteins in human placenta
source: Biochim. Biophys. Acta 1385:165-71
year: 1998

UnificationXref1530
type: UnificationXref
id: 4231738
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231738

3-Phospho-D-glycerate
type: SmallMoleculeReference
name: 3-Phospho-D-glycerate [ChEBI:17794]
name: D-Glycerate 3-phosphate
xref: UnificationXref1494

http://identifiers.org/pubmed/20301236
type: PublicationXref
id: 20301236
author: Freeze, HH
author: Cummings, RD
author: Varki, A
author: Bertozzi, CR
author: Kimata, K
author: Etzler, ME
author: Stanley, P
author: Esko, JD
author: Hart, GW
author: Lindahl, U
db: Pubmed
title: Proteoglycans and Sulfated Glycosaminoglycans
year: 2009

UnificationXref1533
type: UnificationXref
id: 4231744
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231744

UnificationXref1534
type: UnificationXref
id: CHEBI:17489
db: ChEBI

D-ribose 5-phosphate
type: SmallMoleculeReference
name: Ribose 5-phosphate
name: D-ribose 5-phosphate [ChEBI:17797]
xref: UnificationXref1723

UnificationXref1531
type: UnificationXref
id: 4231740
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231740

Leukotriene A4 [ChEBI:6420]
type: SmallMoleculeReference
name: (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyicosa-7,9,11,14-tetraenoate
name: LTA4
name: (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoate
name: Leukotriene A4
xref: UnificationXref2305

UnificationXref1532
type: UnificationXref
id: REACT_157060
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157060.3

UnificationXref1525
type: UnificationXref
id: 29398
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29398

UnificationXref1524
type: UnificationXref
id: CHEBI:32816
db: ChEBI

UnificationXref1527
type: UnificationXref
id: 4231734
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231734

UnificationXref1526
type: UnificationXref
id: REACT_3219
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3219.2

UnificationXref1529
type: UnificationXref
id: 4231737
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231737

UnificationXref1528
type: UnificationXref
id: 4231735
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231735

RelationshipXref400
type: RelationshipXref
id: 4231750
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231750

SequenceSite299
type: SequenceSite
position status: EQUAL
sequence position: 651

RelationshipXref403
type: RelationshipXref
id: GO:0006195
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite296
type: SequenceSite
position status: EQUAL
sequence position: 21

RelationshipXref404
type: RelationshipXref
id: GO:0006144
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite295
type: SequenceSite
position status: EQUAL
sequence position: 732

RelationshipXref401
type: RelationshipXref
id: GO:0004096
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite298
type: SequenceSite
position status: EQUAL
sequence position: 23

RelationshipXref402
type: RelationshipXref
id: 4231969
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231969

SequenceSite297
type: SequenceSite
position status: EQUAL
sequence position: 147

RelationshipXref408
type: RelationshipXref
id: 4231775
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231775

SequenceSite291
type: SequenceSite
position status: EQUAL
sequence position: 389

RelationshipXref407
type: RelationshipXref
id: GO:0004588
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite292
type: SequenceSite
position status: EQUAL
sequence position: 2

RelationshipXref406
type: RelationshipXref
id: 4231781
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231781

SequenceSite293
type: SequenceSite
position status: EQUAL
sequence position: 313

RelationshipXref405
type: RelationshipXref
id: GO:0004152
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite294
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/10620514
type: PublicationXref
id: 10620514
author: Alonso, FJ
author: Campos, JA
author: Marquez, J
author: Del Castillo-Olivares, A
author: Aledo, JC
author: Gomez-Fabre, PM
author: Nunez De Castro, I
db: Pubmed
title: Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase
source: Biochem J 345:365-75
year: 2000

RelationshipXref409
type: RelationshipXref
id: GO:0004590
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite290
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1520
type: UnificationXref
id: 4231517
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231517

Pyruvate metabolism and Citric Acid (TCA) cycle
type: Pathway
data source: Provenance1
pathway component: REACT 138120.5
pathway component: Citric acid cycle (TCA cycle)
evidence: Evidence408
xref: UnificationXref2637
xref: RelationshipXref358
xref: UnificationXref2636
pathway order: PathwayStep394
pathway order: PathwayStep389
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1521
type: UnificationXref
id: 4231518
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231518

UnificationXref1522
type: UnificationXref
id: 4231731
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231731

UnificationXref1523
type: UnificationXref
id: REACT_107128
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107128.9

UnificationXref2215
type: UnificationXref
id: REACT_125475
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125475.1

UnificationXref2216
type: UnificationXref
id: 4232999
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232999

UnificationXref2213
type: UnificationXref
id: CHEBI:28494
db: ChEBI

UnificationXref2214
type: UnificationXref
id: 1524072
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524072

UnificationXref2211
type: UnificationXref
id: 1524038
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524038

http://identifiers.org/pubmed/17224163
type: PublicationXref
id: 17224163
author: Xie, XC
author: Wang, QH
author: Tong, YP
author: Li, SG
author: Zhou, HN
author: Li, SX
author: Han, Y
author: Gao, W
author: Zhang, ZY
author: Zhang, XC
author: Bi, RC
db: Pubmed
title: Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis
source: J Mol Biol 366:1603-14
year: 2007

UnificationXref2212
type: UnificationXref
id: REACT_123458
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123458.1

Hyaluronan uptake and degradation
type: Pathway
data source: Provenance1
pathway component: Beta-glucuronidase (GUSB) hydrolyses glucuronate from the HA disaccharides
pathway component: Beta-glucuronidase (GUSB) hydrolyses glucuronate from HA tetrasaccharides
evidence: Evidence198
xref: UnificationXref1307
xref: UnificationXref1306
xref: RelationshipXref148
pathway order: PathwayStep184
pathway order: PathwayStep185
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2210
type: UnificationXref
id: REACT_124003
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124003.1

UnificationXref1446
type: UnificationXref
id: REACT_114891
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114891.8

UnificationXref1445
type: UnificationXref
id: 4233414
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233414

UnificationXref1444
type: UnificationXref
id: REACT_113083
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113083.8

http://identifiers.org/pubmed/16407156
type: PublicationXref
id: 16407156
author: Beitz, E
author: Wu, B
author: Holm, LM
author: Zeuthen, T
author: Schultz, JE
db: Pubmed
title: Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons
source: Proc Natl Acad Sci U S A 103:269-74
year: 2006

UnificationXref1443
type: UnificationXref
id: 4232205
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232205

UnificationXref1442
type: UnificationXref
id: 4232203
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232203

(R)-2-Methyl-3-oxopropanoyl-CoA [ChEBI:15465]
type: SmallMoleculeReference
name: (R)-3-Oxo-2-methylpropanoyl-CoA
name: (R)-2-Methyl-3-oxopropionyl-CoA
name: (R)-Methylmalonyl-CoA
name: (R)-2-Methyl-3-oxopropanoyl-CoA
xref: UnificationXref1983

UnificationXref1441
type: UnificationXref
id: 4232202
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232202

http://identifiers.org/pubmed/12801959
type: PublicationXref
id: 12801959
author: Burghardt, B
author: Nielsen, S
author: Elkaer, ML
author: Rácz, GZ
author: Kwon, TH
author: Steward, MC
author: Varga, G
db: Pubmed
title: Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas
source: Gut 52:1008-16
year: 2003

UnificationXref1440
type: UnificationXref
id: P62601
db: UniProt

UniProt:P09158
type: ProteinReference
xref: UnificationXref3544
organism: BioSource1

UnificationXref1449
type: UnificationXref
id: REACT_3817
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3817.2

UnificationXref1447
type: UnificationXref
id: CHEBI:17665
db: ChEBI

alpha-linolenic acid (ALA) metabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction186
pathway component: BiochemicalReaction185
evidence: Evidence355
xref: RelationshipXref295
xref: UnificationXref2248
xref: UnificationXref2247
pathway order: PathwayStep341
pathway order: PathwayStep340
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1448
type: UnificationXref
id: 30537
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30537

UniProt:P0AC86
type: ProteinReference
xref: UnificationXref1624
organism: BioSource1

UnificationXref2219
type: UnificationXref
id: 4233511
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233511

UnificationXref2218
type: UnificationXref
id: REACT_143233
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143233.5

UnificationXref2217
type: UnificationXref
id: 4233001
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233001

UnificationXref2224
type: UnificationXref
id: REACT_129852
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129852.5

UnificationXref2225
type: UnificationXref
id: 211579
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211579

UnificationXref2226
type: UnificationXref
id: REACT_119727
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119727.1

UnificationXref2227
type: UnificationXref
id: CHEBI:63540
db: ChEBI

UnificationXref2220
type: UnificationXref
id: REACT_133041
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133041.5

UnificationXref2221
type: UnificationXref
id: 4233360
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233360

UnificationXref2222
type: UnificationXref
id: REACT_140927
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140927.5

UnificationXref2223
type: UnificationXref
id: 4233361
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233361

(S)-3-Hydroxybutanoyl-CoA
type: SmallMoleculeReference
name: (S)-3-Hydroxybutanoyl-CoA [ChEBI:15453]
name: (S)-3-Hydroxybutyryl-CoA
xref: UnificationXref1961

UnificationXref1455
type: UnificationXref
id: CHEBI:16905
db: ChEBI

UnificationXref1454
type: UnificationXref
id: REACT_32507
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32507.10

UnificationXref1457
type: UnificationXref
id: REACT_3740
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3740.1

UnificationXref1456
type: UnificationXref
id: 30014
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30014

UnificationXref1451
type: UnificationXref
id: 4231503
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231503

UnificationXref1450
type: UnificationXref
id: P0A6T1
db: UniProt

UnificationXref1453
type: UnificationXref
id: 4231506
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231506

UnificationXref1452
type: UnificationXref
id: 4231504
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231504

UnificationXref1458
type: UnificationXref
id: P0A796
db: UniProt

UnificationXref1459
type: UnificationXref
id: 4231486
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231486

UnificationXref2229
type: UnificationXref
id: REACT_123619
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123619.1

UnificationXref2228
type: UnificationXref
id: 2046054
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046054

UnificationXref2233
type: UnificationXref
id: 211606
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211606

UnificationXref2234
type: UnificationXref
id: REACT_23217
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23217.1

UnificationXref2231
type: UnificationXref
id: 426639
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426639

UnificationXref2232
type: UnificationXref
id: REACT_123561
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123561.1

UnificationXref2237
type: UnificationXref
id: 4233192
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233192

UnificationXref1460
type: UnificationXref
id: 4231487
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231487

UnificationXref2238
type: UnificationXref
id: REACT_142091
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142091.5

http://identifiers.org/pubmed/7396409
type: PublicationXref
id: 7396409
author: Hopkinson, DA
author: Spencer, N
db: Pubmed
title: Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE)
source: Ann Hum Genet 43:335-42
year: 1980

UnificationXref2235
type: UnificationXref
id: 2046047
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046047

UnificationXref2236
type: UnificationXref
id: REACT_124358
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124358.1

UnificationXref1464
type: UnificationXref
id: 4231491
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231491

UnificationXref1463
type: UnificationXref
id: 4231490
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231490

UnificationXref1462
type: UnificationXref
id: 4231489
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231489

UnificationXref1461
type: UnificationXref
id: 4231488
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231488

http://identifiers.org/pubmed/23256519
type: PublicationXref
id: 23256519
author: Lee, Ethan
author: Wang, Xiaoxi
author: Saito-Diaz, Kenyi
author: Wallace, Heather A
author: Chen, Tony W
author: Thorne, Curtis A
author: Page-McCaw, Andrea
db: Pubmed
title: The way Wnt works: Components and mechanism
source: Growth Factors 31:1-31
year: 2013

UnificationXref1468
type: UnificationXref
id: REACT_31439
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31439.10

UnificationXref2230
type: UnificationXref
id: CHEBI:16749
db: ChEBI

UnificationXref1467
type: UnificationXref
id: 4231495
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231495

UnificationXref1466
type: UnificationXref
id: 4231493
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231493

http://identifiers.org/pubmed/14514708
type: PublicationXref
id: 14514708
author: Stern, R
db: Pubmed
title: Devising a pathway for hyaluronan catabolism: are we there yet?
source: Glycobiology 13:105R-115R
year: 2003

UnificationXref1465
type: UnificationXref
id: 4231492
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231492

UnificationXref1469
type: UnificationXref
id: 4231496
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231496

UnificationXref2239
type: UnificationXref
id: CHEBI:65132
db: ChEBI

UnificationXref2242
type: UnificationXref
id: CHEBI:28125
db: ChEBI

UnificationXref2243
type: UnificationXref
id: 2066763
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066763

UnificationXref2244
type: UnificationXref
id: REACT_123067
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123067.1

UnificationXref2245
type: UnificationXref
id: 4233194
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233194

UnificationXref2246
type: UnificationXref
id: REACT_129923
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129923.5

UnificationXref2247
type: UnificationXref
id: 4233533
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233533

UnificationXref2248
type: UnificationXref
id: REACT_130173
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130173.5

UnificationXref1471
type: UnificationXref
id: CHEBI:28602
db: ChEBI

UnificationXref2249
type: UnificationXref
id: CHEBI:63546
db: ChEBI

UnificationXref1470
type: UnificationXref
id: 4231498
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231498

Protoporphyrinogen IX [ChEBI:8593]
type: SmallMoleculeReference
name: Protoporphyrinogen IX
xref: UnificationXref3681

UnificationXref1473
type: UnificationXref
id: REACT_2510
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2510.1

UnificationXref1472
type: UnificationXref
id: 30533
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30533

UniProt:P25526
type: ProteinReference
xref: UnificationXref1206
organism: BioSource1

UnificationXref1475
type: UnificationXref
id: CHEBI:30769
db: ChEBI

UnificationXref1474
type: UnificationXref
id: 4231500
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231500

UnificationXref1477
type: UnificationXref
id: REACT_2769
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2769.2

Protoporphyrin [ChEBI:8592]
type: SmallMoleculeReference
name: Protoporphyrin
name: Protoporphyrin IX
name: Porphyrinogen IX
xref: UnificationXref3693

UnificationXref1476
type: UnificationXref
id: 76190
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76190

UnificationXref2240
type: UnificationXref
id: 2066765
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066765

UnificationXref1479
type: UnificationXref
id: 4231497
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231497

UnificationXref2241
type: UnificationXref
id: REACT_124023
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124023.1

UnificationXref1478
type: UnificationXref
id: 4231499
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231499

Coproporphyrinogen III [ChEBI:3880]
type: SmallMoleculeReference
name: Coproporphyrinogen III
xref: UnificationXref3660

UniProt:P09148
type: ProteinReference
xref: UnificationXref1662
organism: BioSource1

Uroporphyrinogen III [ChEBI:9905]
type: SmallMoleculeReference
name: Uroporphyrinogen III
xref: UnificationXref3657

UniProt:P09147
type: ProteinReference
xref: UnificationXref1666
organism: BioSource1

http://identifiers.org/pubmed/6248551
type: PublicationXref
id: 6248551
author: Miller, RL
author: Miller, WH
db: Pubmed
title: Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase
source: J Biol Chem 255:7204-7207
year: 1980

http://identifiers.org/pubmed/6300847
type: PublicationXref
id: 6300847
author: Filpula, D
author: Johnson, GG
author: Esty, AC
author: Jolly, DJ
author: Okayama, H
author: Bohlen, P
author: Berg, P
author: Hunkapillar, T
author: Friedmann, T
author: Shively, JE
db: Pubmed
title: Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase
source: Proc Natl Acad Sci U S A 80:477-81
year: 1983

UnificationXref1489
type: UnificationXref
id: 4231483
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231483

Bile salt and organic anion SLC transporters
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction13
evidence: Evidence27
xref: UnificationXref254
xref: UnificationXref253
pathway order: PathwayStep22
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1487
type: UnificationXref
id: 4231480
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231480

http://identifiers.org/pubmed/9792106
type: PublicationXref
id: 9792106
author: Hazlett, TL
author: Sanchez, SA
author: Jameson, DM
author: Brunet, JE
db: Pubmed
title: Aggregation states of mitochondrial malate dehydrogenase
source: Protein Sci 7:2184-2189
year: 1998

UnificationXref1488
type: UnificationXref
id: 4231481
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231481

UnificationXref1485
type: UnificationXref
id: REACT_3912
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3912.2

UnificationXref1486
type: UnificationXref
id: P0A858
db: UniProt

UnificationXref1483
type: UnificationXref
id: CHEBI:29052
db: ChEBI

UnificationXref1484
type: UnificationXref
id: 29578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29578

UnificationXref1481
type: UnificationXref
id: 75970
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=75970

UnificationXref1482
type: UnificationXref
id: REACT_4977
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4977.2

UnificationXref1480
type: UnificationXref
id: CHEBI:16108
db: ChEBI

http://identifiers.org/pubmed/12573255
type: PublicationXref
id: 12573255
author: Hegele, RA
author: Cao, H
author: Mok, A
db: Pubmed
title: Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase
source: Genomics 81:1-5
year: 2003

http://identifiers.org/pubmed/15713083
type: PublicationXref
id: 15713083
author: Teplow, DB
author: Bernstein, SL
author: Baumketner, A
author: Bitan, G
author: Shea, JE
author: Wyttenbach, T
author: Bowers, MT
db: Pubmed
title: Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform
source: J Am Chem Soc 127:2075-84
year: 2005

http://identifiers.org/pubmed/21550412
type: PublicationXref
id: 21550412
author: Crabtree, MJ
author: Channon, KM
db: Pubmed
title: Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
source: Nitric Oxide 25:81-8
year: 2011

beta-D-GlcpA-(1->3)-D-GlcpNAc
type: SmallMoleculeReference
name: beta-D-GlcpA-(1->3)-D-GlcpNAc [ChEBI:64024]
xref: UnificationXref1298

http://identifiers.org/pubmed/6796310
type: PublicationXref
id: 6796310
author: Giesberts, MA
author: Niermeijer, MF
author: van de Kamp, JJ
author: von Figura, K
db: Pubmed
title: Genetic heterogeneity and clinical variability in the Sanfilippo syndrome (types A, B, and C)
source: Clin Genet 20:152-60
year: 1981

UnificationXref1498
type: UnificationXref
id: 29926
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29926

Regulation of gene expression in beta cells
type: Pathway
data source: Provenance1
pathway component: Transcriptional activation of pyruvate kinase gene by ChREBP:MLX
evidence: Evidence23
xref: RelationshipXref17
xref: UnificationXref203
xref: UnificationXref202
pathway order: PathwayStep19
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1499
type: UnificationXref
id: REACT_2525
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2525.2

Xanthine [ChEBI:17712]
type: SmallMoleculeReference
name: Xanthine
xref: UnificationXref2866

http://identifiers.org/pubmed/9374640
type: PublicationXref
id: 9374640
author: Christensen, BM
author: Agre, P
author: King, LS
author: Nielsen, S
db: Pubmed
title: Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat
source: Am J Physiol 273:C1549-61
year: 1997

UnificationXref1494
type: UnificationXref
id: CHEBI:17794
db: ChEBI

UnificationXref1495
type: UnificationXref
id: 29728
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29728

UnificationXref1496
type: UnificationXref
id: REACT_3406
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3406.2

UnificationXref1497
type: UnificationXref
id: CHEBI:18420
db: ChEBI

UnificationXref1490
type: UnificationXref
id: REACT_95650
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95650.9

UnificationXref1491
type: UnificationXref
id: CHEBI:16001
db: ChEBI

UnificationXref1492
type: UnificationXref
id: 29800
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29800

UnificationXref1493
type: UnificationXref
id: REACT_3116
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3116.2

http://identifiers.org/pubmed/8428933
type: PublicationXref
id: 8428933
author: Doroshow, JH
author: Esworthy, RS
author: Chu, FF
db: Pubmed
title: Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI
source: J Biol Chem 268:2571-6
year: 1993

3-Oxopalmitoyl-CoA
type: SmallMoleculeReference
name: 3-Oxopalmitoyl-CoA [ChEBI:15491]
name: 3-Oxohexadecanoyl-CoA
name: 3-ketopalmitoyl-CoA
xref: UnificationXref1849

http://identifiers.org/pubmed/2846554
type: PublicationXref
id: 2846554
author: Prome, D
author: Rosa, R
author: Cohen-Solal, M
author: Pratbernou, F
author: Prome, JC
author: Rosa, J
author: Calvin, MC
author: Blouquit, Y
db: Pubmed
title: Sequence of the human erythrocyte phosphoglycerate mutase by microsequencer and mass spectrometry
source: J Biol Chem 263:16906-10
year: 1988

http://identifiers.org/pubmed/9374639
type: PublicationXref
id: 9374639
author: Agre, P
author: Nielsen, S
author: King, LS
db: Pubmed
title: Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat
source: Am J Physiol 273:C1541-8
year: 1997

2'-deoxyadenosine 5'-monophosphate [ChEBI:17713]
type: SmallMoleculeReference
name: deoxyadenylic acid
name: dAMP
name: 2'-deoxyadenosine 5'-monophosphate
xref: UnificationXref1737

http://identifiers.org/pubmed/6323448
type: PublicationXref
id: 6323448
author: Cline, A
author: Moulton, AD
author: Nienhuis, AW
author: Chen, MJ
author: Humphries, RK
author: Shimada, T
author: Maizel, J
db: Pubmed
title: The functional human dihydrofolate reductase gene
source: J Biol Chem 259:3933-43
year: 1984

PublicationXref794
type: PublicationXref
id: 978-0-444-53219-0
author: Smith, William L
author: Murphy, RC
db: ISBN
title: The eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase pathways
source: Biochemistry of Lipids, Lipoproteins and Membranes, 5th Edition (Book): 331-362
year: 2008

Phase 1 - Functionalization of compounds
type: Pathway
data source: Provenance1
pathway component: REACT 114164.8
evidence: Evidence566
xref: UnificationXref3736
xref: UnificationXref3737
xref: RelationshipXref568
pathway order: PathwayStep553
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:P07813
type: ProteinReference
xref: UnificationXref908
organism: BioSource1

http://identifiers.org/pubmed/11594753
type: PublicationXref
id: 11594753
author: Ludwig, A
author: Niere, M
author: Ziegler, M
author: Lerner, F
db: Pubmed
title: Structural and functional characterization of human NAD kinase
source: Biochem Biophys Res Commun 288:69-74
year: 2001

APS
type: SmallMoleculeReference
name: Adenosine 5'-phosphosulfate
name: Adenylylsulfate
name: Adenylylsulfate [ChEBI:17709]
xref: UnificationXref1313

2-Hydroxyphytanoyl-CoA [ChEBI:1170]
type: SmallMoleculeReference
name: 2-Hydroxyphytanoyl-CoA
xref: UnificationXref2055

But-2-enoyl-CoA
type: SmallMoleculeReference
name: Crotonyl-CoA
name: Crotonoyl-CoA [ChEBI:15473]
name: trans-But-2-enoyl-CoA
name: 2-Butenoyl-CoA
name: Crotonoyl-CoA
xref: UnificationXref1958

2-trans-Dodecenoyl-CoA
type: SmallMoleculeReference
name: 2-trans-Dodecenoyl-CoA [ChEBI:15471]
name: trans-Dodec-2-enoyl-CoA
xref: UnificationXref1883

UnificationXref2201
type: UnificationXref
id: REACT_124080
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124080.1

UnificationXref2200
type: UnificationXref
id: 1524067
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524067

UnificationXref2203
type: UnificationXref
id: 4233004
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233004

UnificationXref2202
type: UnificationXref
id: P23830
db: UniProt

http://identifiers.org/pubmed/14514735
type: PublicationXref
id: 14514735
author: Walker, RJ
author: Bedford, JJ
author: Leader, JP
db: Pubmed
title: Aquaporin expression in normal human kidney and in renal disease
source: J Am Soc Nephrol 14:2581-7
year: 2003

UnificationXref2205
type: UnificationXref
id: REACT_146408
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146408.5

UnificationXref2204
type: UnificationXref
id: 4233006
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233006

UnificationXref2206
type: UnificationXref
id: 4233512
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233512

UnificationXref2207
type: UnificationXref
id: REACT_147250
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147250.5

UnificationXref2208
type: UnificationXref
id: CHEBI:60430
db: ChEBI

UniProt:P0AC53
type: ProteinReference
xref: UnificationXref1678
organism: BioSource1

UnificationXref2209
type: UnificationXref
id: 1498773
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1498773

http://identifiers.org/pubmed/6816802
type: PublicationXref
id: 6816802
author: Simon, TC
author: Bryant, RW
author: Bailey, JM
db: Pubmed
title: Role of glutathione peroxidase and hexose monophosphate shunt in the platelet lipoxygenase pathway
source: J Biol Chem 257:14937-43
year: 1982

UnificationXref3748
type: UnificationXref
id: 4233397
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233397

UnificationXref3749
type: UnificationXref
id: REACT_113503
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113503.8

UnificationXref3746
type: UnificationXref
id: 4233396
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233396

UnificationXref3747
type: UnificationXref
id: REACT_113773
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113773.8

ROS
type: SmallMoleculeReference
name: Reactive oxygen species
name: Reactive oxygen species [ChEBI:26523]
xref: UnificationXref777

UnificationXref3745
type: UnificationXref
id: REACT_112524
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112524.8

UnificationXref3744
type: UnificationXref
id: 4232172
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232172

UnificationXref3743
type: UnificationXref
id: 4232170
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232170

UnificationXref3742
type: UnificationXref
id: 4232169
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232169

Leukotriene D4 [ChEBI:6423]
type: SmallMoleculeReference
name: LTD4
name: Leukotriene D4
xref: UnificationXref2324

UnificationXref3741
type: UnificationXref
id: P76373
db: UniProt

UnificationXref2297
type: UnificationXref
id: 2161684
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161684

UnificationXref3740
type: UnificationXref
id: REACT_4445
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4445.4

UnificationXref2298
type: UnificationXref
id: REACT_150521
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150521.1

UnificationXref2299
type: UnificationXref
id: P76113
db: UniProt

UnificationXref2293
type: UnificationXref
id: REACT_150671
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150671.1

UnificationXref2294
type: UnificationXref
id: CHEBI:63976
db: ChEBI

UnificationXref2295
type: UnificationXref
id: 2142751
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142751

UnificationXref2296
type: UnificationXref
id: REACT_150881
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150881.1

UnificationXref2290
type: UnificationXref
id: REACT_151621
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151621.1

UnificationXref2291
type: UnificationXref
id: CHEBI:15550
db: ChEBI

UnificationXref2292
type: UnificationXref
id: 2142749
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142749

http://identifiers.org/pubmed/6311078
type: PublicationXref
id: 6311078
author: Hammarström, Sven
db: Pubmed
title: Leukotrienes
source: Annu Rev Biochem 52:355-77
year: 1983

Metabolism of steroid hormones and vitamin D
type: Pathway
data source: Provenance1
pathway component: REACT 142341.5
evidence: Evidence341
xref: UnificationXref2161
xref: RelationshipXref279
xref: UnificationXref2160
pathway order: PathwayStep160
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10571006
type: PublicationXref
id: 10571006
author: Callahan, J W
db: Pubmed
title: Molecular basis of GM1 gangliosidosis and Morquio disease, type B. Structure-function studies of lysosomal beta-galactosidase and the non-lysosomal beta-galactosidase-like protein
source: Biochim. Biophys. Acta 1455:85-103
year: 1999

http://identifiers.org/pubmed/22527994
type: PublicationXref
id: 22527994
author: Monaga, Madelyn
author: Campos, Derbis
db: Pubmed
title: Mucopolysaccharidosis type I: current knowledge on its pathophysiological mechanisms
source: Metab Brain Dis 27:121-9
year: 2012

UnificationXref3757
type: UnificationXref
id: REACT_33816
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33816.10

UnificationXref3758
type: UnificationXref
id: CHEBI:16580
db: ChEBI

UnificationXref3759
type: UnificationXref
id: 158847
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158847

http://identifiers.org/pubmed/12126930
type: PublicationXref
id: 12126930
author: Jakobs, C
author: Patel, A
author: Geraghty, MT
author: Thomas, GH
author: Schor, DS
author: Salomons, GS
author: Goh, DL
db: Pubmed
title: Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).
source: Mol Genet Metab 76:172-80
year: 2002

UnificationXref3754
type: UnificationXref
id: MOD:00065
db: MOD

UnificationXref3753
type: UnificationXref
id: 4232150
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232150

UnificationXref3756
type: UnificationXref
id: 4232153
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232153

UnificationXref3755
type: UnificationXref
id: 4232152
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232152

UnificationXref3750
type: UnificationXref
id: 4233399
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233399

UnificationXref3752
type: UnificationXref
id: P77567
db: UniProt

UnificationXref3751
type: UnificationXref
id: REACT_157432
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157432.3

haem o
type: SmallMoleculeReference
name: heme o [ChEBI:24480]
name: heme o
xref: UnificationXref3712

http://identifiers.org/pubmed/21245903
type: PublicationXref
id: 21245903
author: Kufer, TA
author: Sansonetti, PJ
db: Pubmed
title: NLR functions beyond pathogen recognition
source: Nat Immunol 12:121-8
year: 2011

UnificationXref3768
type: UnificationXref
id: 174965
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174965

UnificationXref3769
type: UnificationXref
id: REACT_7035
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7035.2

UnificationXref3763
type: UnificationXref
id: REACT_7912
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7912.2

UnificationXref3762
type: UnificationXref
id: 174970
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174970

UnificationXref3761
type: UnificationXref
id: CHEBI:30753
db: ChEBI

3beta-Hydroxyandrost-5-en-17-one
type: SmallMoleculeReference
name: Dehydroepiandrosterone [ChEBI:28689]
name: DHEA
name: Dehydroisoandrosterone
name: Dehydroepiandrosterone
name: DHA
xref: UnificationXref2436

UnificationXref3760
type: UnificationXref
id: REACT_2321
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2321.2

UnificationXref3767
type: UnificationXref
id: CHEBI:45373
db: ChEBI

UniProt:P0ACB2
type: ProteinReference
xref: UnificationXref3632
organism: BioSource1

UnificationXref3766
type: UnificationXref
id: REACT_7213
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7213.2

UnificationXref3765
type: UnificationXref
id: 174973
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174973

UnificationXref3764
type: UnificationXref
id: CHEBI:27565
db: ChEBI

http://identifiers.org/pubmed/14609716
type: PublicationXref
id: 14609716
author: Karlsson, A
author: Johansson, M
author: Van Rompay, AR
db: Pubmed
title: Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
source: Pharmacol Ther 100:119-139
year: 2003

UnificationXref3779
type: UnificationXref
id: 174957
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174957

UnificationXref3772
type: UnificationXref
id: CHEBI:16395
db: ChEBI

http://identifiers.org/pubmed/17397399
type: PublicationXref
id: 17397399
author: Kikuchi, Akira
author: Komekado, Hideyuki
author: Chiba, Tsutomu
author: Yamamoto, Hideki
db: Pubmed
title: Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a
source: Genes Cells 12:521-34
year: 2007

UnificationXref3771
type: UnificationXref
id: REACT_7517
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7517.1

UnificationXref3774
type: UnificationXref
id: REACT_7760
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7760.1

UnificationXref3773
type: UnificationXref
id: 158853
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158853

UnificationXref3776
type: UnificationXref
id: 174968
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174968

UnificationXref3775
type: UnificationXref
id: CHEBI:63815
db: ChEBI

UnificationXref3778
type: UnificationXref
id: CHEBI:63817
db: ChEBI

UnificationXref3777
type: UnificationXref
id: REACT_7050
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7050.2

Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX
type: TemplateReaction
data source: Provenance1
evidence: Evidence390
product: LPAAT-alpha
xref: UnificationXref2525
xref: UnificationXref2524
participant: LPAAT-alpha
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

Activation of E2F target genes at G1/S
type: TemplateReaction
data source: Provenance1
evidence: Evidence184
product: PhysicalEntity21
xref: UnificationXref1237
xref: UnificationXref1236
participant: PhysicalEntity21
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

Expression of Asparagine Synthetase
type: TemplateReaction
data source: Provenance1
evidence: Evidence163
product: P22106
xref: UnificationXref1134
xref: UnificationXref1133
participant: P22106
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

Expression of DNAJB9
type: TemplateReaction
data source: Provenance1
evidence: Evidence160
product: P36659
xref: UnificationXref1125
xref: UnificationXref1126
participant: P36659
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

UnificationXref3770
type: UnificationXref
id: 174969
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174969

Expression of HSP90B1 (Endoplasmin)
type: TemplateReaction
data source: Provenance1
evidence: Evidence157
product: Endoplasmin
xref: UnificationXref1117
xref: UnificationXref1118
participant: Endoplasmin
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

Transcriptional activation of pyruvate kinase gene by ChREBP:MLX
type: TemplateReaction
data source: Provenance1
evidence: Evidence22
evidence: Evidence21
product: Protein48
xref: UnificationXref201
xref: UnificationXref200
participant: Protein48
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

UnificationXref3780
type: UnificationXref
id: REACT_7245
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7245.2

UnificationXref2250
type: UnificationXref
id: 2046050
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046050

UnificationXref3781
type: UnificationXref
id: CHEBI:63845
db: ChEBI

UnificationXref2252
type: UnificationXref
id: 2046055
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046055

UnificationXref2251
type: UnificationXref
id: REACT_123419
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123419.1

UnificationXref3788
type: UnificationXref
id: CHEBI:25858
db: ChEBI

UnificationXref2258
type: UnificationXref
id: 4233534
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233534

UnificationXref3789
type: UnificationXref
id: 158687
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158687

UnificationXref2257
type: UnificationXref
id: REACT_128260
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128260.5

UnificationXref3786
type: UnificationXref
id: 4232183
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232183

UnificationXref3787
type: UnificationXref
id: REACT_82229
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82229.9

UnificationXref2259
type: UnificationXref
id: REACT_131194
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131194.5

UnificationXref3784
type: UnificationXref
id: 174960
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174960

UnificationXref2254
type: UnificationXref
id: 4233193
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233193

UnificationXref3785
type: UnificationXref
id: REACT_7900
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7900.1

UnificationXref2253
type: UnificationXref
id: REACT_123939
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123939.1

UnificationXref3782
type: UnificationXref
id: 174961
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174961

UnificationXref2256
type: UnificationXref
id: 4233535
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233535

THF-polyglutamate
type: SmallMoleculeReference
name: Tetrahydrofolyl-[Glu](n)
name: Tetrahydrofolyl-[Glu](n) [ChEBI:9484]
name: Tetrahydrofolyl-[Glu](n+1)
xref: UnificationXref3263

http://identifiers.org/pubmed/4320262
type: PublicationXref
id: 4320262
author: Larner, J
author: Villar-Palasi, C
db: Pubmed
title: Glycogen metabolism and glycolytic enzymes
source: Annu Rev Biochem 39:639-72
year: 1970

UnificationXref3783
type: UnificationXref
id: REACT_7843
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7843.1

UnificationXref2255
type: UnificationXref
id: REACT_139981
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139981.5

http://identifiers.org/pubmed/2925663
type: PublicationXref
id: 2925663
author: Ambroziak, W
author: Pietruszko, R
author: Kurys, G
db: Pubmed
title: Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde.
source: J Biol Chem 264:4715-21
year: 1989

UnificationXref2263
type: UnificationXref
id: CHEBI:15551
db: ChEBI

UnificationXref3790
type: UnificationXref
id: REACT_7429
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7429.2

UnificationXref2262
type: UnificationXref
id: REACT_24396
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24396.2

LXA4
type: SmallMoleculeReference
name: Lipoxin A4 [ChEBI:6498]
name: 5S,6R,15S-trihydroxy-7E,9E,11Z,13E-Eicosatetraenoic acid
name: Lipoxin A4
xref: UnificationXref2392

UnificationXref3791
type: UnificationXref
id: CHEBI:6030
db: ChEBI

UnificationXref2261
type: UnificationXref
id: 879629
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879629

UnificationXref3792
type: UnificationXref
id: 159316
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159316

UnificationXref2260
type: UnificationXref
id: CHEBI:15555
db: ChEBI

http://identifiers.org/pubmed/17132626
type: PublicationXref
id: 17132626
author: Forman, HJ
author: Persechini, PM
author: Ojcius, DM
author: Ventura, AL
author: Rinna, A
author: Cruz, CM
db: Pubmed
title: ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages
source: J Biol Chem 282:2871-9
year: 2007

UnificationXref3797
type: UnificationXref
id: 158676
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158676

UnificationXref3798
type: UnificationXref
id: REACT_7479
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7479.3

UnificationXref3799
type: UnificationXref
id: CHEBI:7207
db: ChEBI

UnificationXref2269
type: UnificationXref
id: 2161661
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161661

http://identifiers.org/pubmed/15877282
type: PublicationXref
id: 15877282
author: Eshhar, S
author: Elpeleg, O
author: Saada, A
author: Miller, C
author: Bondi-Rubinstein, G
author: Pagnamenta, A
author: Rahman, S
author: Bitner-Glindzicz, M
author: Hershkovitz, E
db: Pubmed
title: Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion
source: Am J Hum Genet 76:1081-6
year: 2005

UnificationXref2268
type: UnificationXref
id: REACT_24606
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24606.2

UnificationXref3793
type: UnificationXref
id: REACT_7505
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7505.2

UnificationXref2267
type: UnificationXref
id: 879535
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879535

UnificationXref3794
type: UnificationXref
id: 174971
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174971

UnificationXref2266
type: UnificationXref
id: CHEBI:15553
db: ChEBI

(S)-3-Hydroxyoctanoyl-CoA
type: SmallMoleculeReference
name: (S)-Hydroxyoctanoyl-CoA [ChEBI:28632]
name: (S)-Hydroxyoctanoyl-CoA
xref: UnificationXref1925

UnificationXref3795
type: UnificationXref
id: REACT_7193
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7193.1

UnificationXref2265
type: UnificationXref
id: REACT_15804
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15804.2

UnificationXref3796
type: UnificationXref
id: CHEBI:32643
db: ChEBI

UnificationXref2264
type: UnificationXref
id: 265287
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265287

http://identifiers.org/pubmed/15450248
type: PublicationXref
id: 15450248
author: Shi, Q
author: Huang, S
author: Wei, D
author: Xie, K
db: Pubmed
title: Constitutive and inducible expression and regulation of vascular endothelial growth factor
source: Cytokine Growth Factor Rev 15:297-324
year: 2004

UnificationXref2270
type: UnificationXref
id: REACT_150622
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150622.1

UnificationXref2272
type: UnificationXref
id: 2142752
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142752

UnificationXref2271
type: UnificationXref
id: CHEBI:15557
db: ChEBI

UnificationXref2274
type: UnificationXref
id: CHEBI:15547
db: ChEBI

UnificationXref2273
type: UnificationXref
id: REACT_151260
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151260.1

UnificationXref2276
type: UnificationXref
id: REACT_151184
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151184.1

Procainamide [ChEBI:8428]
type: SmallMoleculeReference
name: Procainamide
xref: UnificationXref223

UnificationXref2275
type: UnificationXref
id: 2142721
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142721

http://identifiers.org/pubmed/8163052
type: PublicationXref
id: 8163052
author: Gomis, R
author: Malaisse, WJ
author: Sener, A
author: Fernandez-Alvarez, J
author: Conget, I
author: Rasschaert, J
db: Pubmed
title: Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients
source: Diabetologia 37:177-81
year: 1994

UnificationXref2278
type: UnificationXref
id: 2142799
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142799

UnificationXref2277
type: UnificationXref
id: CHEBI:28442
db: ChEBI

UnificationXref2279
type: UnificationXref
id: REACT_152334
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152334.1

UniProt:P00509
type: ProteinReference
xref: UnificationXref1586
organism: BioSource1

http://identifiers.org/pubmed/9461497
type: PublicationXref
id: 9461497
author: Zhang, H
author: Tai, HH
author: Ensor, CM
db: Pubmed
title: Purification, cDNA cloning and expression of 15-oxoprostaglandin 13-reductase from pig lung
source: Biochem J 330:103-8
year: 1998

UnificationXref2281
type: UnificationXref
id: REACT_151444
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151444.1

UnificationXref2280
type: UnificationXref
id: 2161597
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161597

UnificationXref2285
type: UnificationXref
id: 4233207
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233207

UnificationXref2284
type: UnificationXref
id: P77646
db: UniProt

UnificationXref2283
type: UnificationXref
id: REACT_5115
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5115.1

Regulation of Water Balance by Renal Aquaporins
type: Pathway
data source: Provenance1
pathway component: Passive Transport of Water into Cell by Aquaporin-1
pathway component: Passive Transport of Water into Cell by Aquaporin-2 Phosphorylated on Serine256
pathway component: Passive Transport of Water out of Cell by Aquaporin-1
pathway component: Passive Transport of Water out of Cell by Aquaporin-4
pathway component: Passive Transport of Water out of Cell by Aquaporin-3
evidence: Evidence105
xref: RelationshipXref72
xref: UnificationXref728
xref: UnificationXref727
pathway order: PathwayStep98
pathway order: PathwayStep96
pathway order: PathwayStep97
pathway order: PathwayStep94
pathway order: PathwayStep95
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2282
type: UnificationXref
id: 73473
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73473

UnificationXref2289
type: UnificationXref
id: 2161650
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161650

UnificationXref2288
type: UnificationXref
id: REACT_156569
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156569.3

http://identifiers.org/pubmed/14990995
type: PublicationXref
id: 14990995
author: Yoshida, K
author: Inoue, I
db: Pubmed
title: Regulation of Geminin and Cdt1 expression by E2F transcription factors
source: Oncogene 23:3802-12
year: 2004

UnificationXref2287
type: UnificationXref
id: 4233210
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233210

UnificationXref2286
type: UnificationXref
id: 4233208
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233208

http://identifiers.org/pubmed/21111842
type: PublicationXref
id: 21111842
author: Kefalov, Vladimir J
author: Wang, Jin-Shan
db: Pubmed
title: The cone-specific visual cycle
source: Prog Retin Eye Res 30:115-28
year: 2011

PublicationXref709
type: PublicationXref
id: 0079130356
author: Rosenblatt, DS
author: Fenton, WA
author: Gravel, RA
db: ISBN
title: Disorders of propionate and methylmalonate metabolism
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 2165-2193
year: 2001

RelationshipXref392
type: RelationshipXref
id: 4231918
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231918

RelationshipXref391
type: RelationshipXref
id: GO:0004422
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref390
type: RelationshipXref
id: 4231912
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231912

RelationshipXref396
type: RelationshipXref
id: GO:0008253
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref395
type: RelationshipXref
id: GO:0043101
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref394
type: RelationshipXref
id: 4232742
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232742

RelationshipXref393
type: RelationshipXref
id: GO:0003920
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref399
type: RelationshipXref
id: 4231936
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231936

RelationshipXref398
type: RelationshipXref
id: GO:0008892
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref397
type: RelationshipXref
id: 4232005
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232005

http://identifiers.org/pubmed/6434529
type: PublicationXref
id: 6434529
author: Chuang, DT
author: Cox, RP
author: Markovitz, PJ
db: Pubmed
title: Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.
source: J Biol Chem 259:11643-6
year: 1984

http://identifiers.org/pubmed/15071553
type: PublicationXref
id: 15071553
author: Kühlbrandt, W
db: Pubmed
title: Biology, structure and mechanism of P-type ATPases
source: Nat Rev Mol Cell Biol 5:282-95
year: 2004

'ATP [nucleoplasm]' negatively regulates 'phosphoenolpyruvate + ADP => pyruvate + ATP'
type: Control
data source: Provenance1
xref: UnificationXref1537
controlled: BiochemicalReaction114
control type: INHIBITION
controller: Adenosine 5'-triphosphate

'3',5'-Cyclic AMP [cytosol]' negatively regulates 'phosphoenolpyruvate + ADP => pyruvate + ATP'
type: Control
data source: Provenance1
xref: UnificationXref1533
controlled: BiochemicalReaction114
control type: INHIBITION
controller: Cyclic AMP

'Ac-CoA [cytosol]' negatively regulates 'phosphoenolpyruvate + ADP => pyruvate + ATP'
type: Control
data source: Provenance1
xref: UnificationXref1540
controlled: BiochemicalReaction114
control type: INHIBITION
controller: Acetyl coenzyme A

http://identifiers.org/pubmed/17012249
type: PublicationXref
id: 17012249
author: Chen, LM
author: Pelletier, MF
author: Gros, G
author: Musa-Aziz, R
author: Endeward, V
author: King, LS
author: Virkki, LV
author: Boron, WF
author: Cooper, GJ
author: Supuran, CT
db: Pubmed
title: Evidence that aquaporin 1 is a major pathway for CO2 transport across the human erythrocyte membrane
source: FASEB J 20:1974-81
year: 2006

http://identifiers.org/pubmed/8946167
type: PublicationXref
id: 8946167
author: Blanch, L
author: Anson, D S
author: Hopwood, J J
author: Scott, H S
author: Guo, X H
author: Karageorgos, L E
author: Weber, B
db: Pubmed
title: Structure and sequence of the human sulphamidase gene
source: DNA Res. 3:269-71
year: 1996

Activation of Chaperones by IRE1alpha
type: Pathway
data source: Provenance1
pathway component: Activation of Chaperone Genes by XBP1(S)
evidence: Evidence162
xref: UnificationXref1130
xref: RelationshipXref125
xref: UnificationXref1129
pathway order: PathwayStep153
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

'D-Fructose 2,6-bisphosphate [cytosol]' positively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Provenance1
xref: UnificationXref1470
controlled: BiochemicalReaction109
control type: ACTIVATION
controller: D-Fructose 2,6-bisphosphate

'CIT [cytosol]' negatively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Provenance1
xref: UnificationXref1474
controlled: BiochemicalReaction109
control type: INHIBITION
controller: Citrate

trans-Hex-2-enoyl-CoA [ChEBI:28706]
type: SmallMoleculeReference
name: trans-Hex-2-enoyl-CoA
xref: UnificationXref1940

'ATP [cytosol]' negatively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Provenance1
xref: UnificationXref1478
controlled: BiochemicalReaction109
control type: INHIBITION
controller: Adenosine 5'-triphosphate

'ADP [cytosol]' positively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Provenance1
xref: UnificationXref1479
controlled: BiochemicalReaction109
control type: ACTIVATION
controller: Adenosine 5'-diphosphate

'L-Asp [lysosomal lumen]' negatively regulates 'Beta-glucuronidase (GUSB) hydrolyses glucuronate from the linker chain'
type: Control
data source: Provenance1
xref: UnificationXref1363
controlled: BiochemicalReaction104
control type: INHIBITION
controller: SmallMolecule234

'AMP [cytosol]' positively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Provenance1
xref: UnificationXref1469
controlled: BiochemicalReaction109
control type: ACTIVATION
controller: SmallMolecule137

http://identifiers.org/pubmed/11826276
type: PublicationXref
id: 11826276
author: Bennett, MJ
author: Rinaldo, P
author: Matern, D
db: Pubmed
title: Fatty acid oxidation disorders.
source: Annu Rev Physiol 64:477-502
year: 2002

RelationshipXref374
type: RelationshipXref
id: 4231852
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231852

SequenceSite303
type: SequenceSite
position status: EQUAL
sequence position: 614

RelationshipXref373
type: RelationshipXref
id: GO:0004643
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite304
type: SequenceSite
position status: EQUAL
sequence position: 91

RelationshipXref372
type: RelationshipXref
id: 4231858
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231858

SequenceSite305
type: SequenceSite
position status: EQUAL
sequence position: 37

RelationshipXref371
type: RelationshipXref
id: GO:0004639
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite306
type: SequenceSite
position status: EQUAL
sequence position: 552

RelationshipXref370
type: RelationshipXref
id: 4231860
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231860

SequenceSite307
type: SequenceSite
position status: EQUAL
sequence position: 91

SequenceSite308
type: SequenceSite
position status: EQUAL
sequence position: 37

SequenceSite309
type: SequenceSite
position status: EQUAL
sequence position: 533

RelationshipXref379
type: RelationshipXref
id: GO:0003921
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref378
type: RelationshipXref
id: 4231843
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231843

RelationshipXref377
type: RelationshipXref
id: GO:0003938
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite300
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref376
type: RelationshipXref
id: 4231850
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231850

SequenceSite301
type: SequenceSite
position status: EQUAL
sequence position: 624

RelationshipXref375
type: RelationshipXref
id: GO:0003937
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite302
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref383
type: RelationshipXref
id: GO:0009168
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite316
type: SequenceSite
position status: EQUAL
sequence position: 556

RelationshipXref382
type: RelationshipXref
id: 4232104
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232104

SequenceSite317
type: SequenceSite
position status: EQUAL
sequence position: 24

RelationshipXref385
type: RelationshipXref
id: 4231923
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231923

SequenceSite314
type: SequenceSite
position status: EQUAL
sequence position: 24

RelationshipXref384
type: RelationshipXref
id: GO:0004000
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite315
type: SequenceSite
position status: EQUAL
sequence position: 556

RelationshipXref381
type: RelationshipXref
id: GO:0004019
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite318
type: SequenceSite
position status: EQUAL
sequence position: 556

RelationshipXref380
type: RelationshipXref
id: 4231837
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231837

SequenceSite319
type: SequenceSite
position status: EQUAL
sequence position: 2

ChEBI:28726 3-oxotetradecanoyl-CoA
type: SmallMoleculeReference
name: 3-oxotetradecanoyl-CoA
name: 3-Oxotetradecanoyl-CoA
xref: UnificationXref1871

http://identifiers.org/pubmed/10843999
type: PublicationXref
id: 10843999
author: Hannah, VC
author: Luong, A
author: Goldstein, JL
db: Pubmed
title: Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins.
source: J Biol Chem 275:26458-66
year: 2000

RelationshipXref387
type: RelationshipXref
id: GO:0004731
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite312
type: SequenceSite
position status: EQUAL
sequence position: 533

RelationshipXref386
type: RelationshipXref
id: 4233197
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233197

SequenceSite313
type: SequenceSite
position status: EQUAL
sequence position: 556

Synthesis of 12-eicosatetraenoic acid derivatives
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction196
pathway component: BiochemicalReaction195
evidence: Evidence372
xref: UnificationXref2390
xref: RelationshipXref312
xref: UnificationXref2391
pathway order: PathwayStep357
pathway order: PathwayStep358
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref389
type: RelationshipXref
id: GO:0003999
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite310
type: SequenceSite
position status: EQUAL
sequence position: 91

RelationshipXref388
type: RelationshipXref
id: 4231929
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231929

SequenceSite311
type: SequenceSite
position status: EQUAL
sequence position: 37

Recognition and association of DNA glycosylase with site containing an affected pyrimidine
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction19
pathway component: BiochemicalReaction18
pathway component: BiochemicalReaction22
pathway component: BiochemicalReaction21
pathway component: BiochemicalReaction20
pathway component: BiochemicalReaction16
pathway component: BiochemicalReaction17
evidence: Evidence40
xref: UnificationXref308
xref: RelationshipXref24
xref: UnificationXref307
pathway order: PathwayStep28
pathway order: PathwayStep29
pathway order: PathwayStep31
pathway order: PathwayStep33
pathway order: PathwayStep34
pathway order: PathwayStep32
pathway order: PathwayStep30
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

ABC-family proteins mediated transport
type: Pathway
data source: Provenance1
pathway component: REACT 114103.8
evidence: Evidence55
xref: RelationshipXref32
xref: UnificationXref380
xref: UnificationXref381
pathway order: PathwayStep48
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3711
type: UnificationXref
id: REACT_161071
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161071.1

UnificationXref3712
type: UnificationXref
id: CHEBI:24480
db: ChEBI

UnificationXref3710
type: UnificationXref
id: 2162257
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162257

http://identifiers.org/pubmed/10468558
type: PublicationXref
id: 10468558
author: Van Veldhoven, PP
author: Casteels, M
author: Waelkens, E
author: Foulon, V
author: Antonenkov, VD
author: Croes, K
author: Mannaerts, GP
db: Pubmed
title: Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids
source: Proc Natl Acad Sci U S A 96:10039-44
year: 1999

UnificationXref3716
type: UnificationXref
id: 4233303
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233303

RelationshipXref355
type: RelationshipXref
id: GO:0047988
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite322
type: SequenceSite
position status: EQUAL
sequence position: 780

UnificationXref3715
type: UnificationXref
id: P0AEA5
db: UniProt

RelationshipXref356
type: RelationshipXref
id: 4232764
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232764

SequenceSite321
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref3714
type: UnificationXref
id: REACT_165517
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_165517.1

RelationshipXref353
type: RelationshipXref
id: GO:0051990
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite324
type: SequenceSite
position status: EQUAL
sequence position: 784

UnificationXref3713
type: UnificationXref
id: 2995328
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2995328

RelationshipXref354
type: RelationshipXref
id: 4232769
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232769

SequenceSite323
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref359
type: RelationshipXref
id: GO:0004044
db: GENE ONTOLOGY
relationship type: MI:0355

UniProt:Q46916
type: ProteinReference
xref: UnificationXref71
organism: BioSource1

UnificationXref3719
type: UnificationXref
id: 4233418
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233418

UniProt:P76113
type: ProteinReference
xref: UnificationXref2299
organism: BioSource1

UnificationXref3718
type: UnificationXref
id: REACT_167109
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_167109.1

RelationshipXref357
type: RelationshipXref
id: GO:0006103
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite320
type: SequenceSite
position status: EQUAL
sequence position: 558

UnificationXref3717
type: UnificationXref
id: 4233305
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233305

RelationshipXref358
type: RelationshipXref
id: GO:0044237
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite329
type: SequenceSite
position status: EQUAL
sequence position: 2

RelationshipXref351
type: RelationshipXref
id: GO:0047545
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite326
type: SequenceSite
position status: EQUAL
sequence position: 286

Cell Cycle, Mitotic
type: Pathway
data source: Provenance1
pathway component: Mitotic G1-G1/S phases
evidence: Evidence189
xref: UnificationXref1246
xref: UnificationXref1247
xref: RelationshipXref145
pathway order: PathwayStep177
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref352
type: RelationshipXref
id: 4232778
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232778

SequenceSite325
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite328
type: SequenceSite
position status: EQUAL
sequence position: 417

RelationshipXref350
type: RelationshipXref
id: GO:0006099
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite327
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/11742412
type: PublicationXref
id: 11742412
author: Saltiel, AR
author: Kahn, CR
db: Pubmed
title: Insulin signalling and the regulation of glucose and lipid metabolism
source: Nature 414:799-806
year: 2001

UniProt:Q46911
type: ProteinReference
xref: UnificationXref2111
organism: BioSource1

UnificationXref3700
type: UnificationXref
id: 4230480
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230480

UnificationXref3701
type: UnificationXref
id: P23871
db: UniProt

UnificationXref3703
type: UnificationXref
id: 4232239
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232239

RelationshipXref364
type: RelationshipXref
id: 4231872
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231872

SequenceSite335
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref3702
type: UnificationXref
id: 4232238
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232238

RelationshipXref365
type: RelationshipXref
id: GO:0004642
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite334
type: SequenceSite
position status: EQUAL
sequence position: 434

http://identifiers.org/pubmed/18660845
type: PublicationXref
id: 18660845
author: Zhao, FQ
author: Keating, AF
db: Pubmed
title: Functional properties and genomics of glucose transporters
source: Curr Genomics 8:113-28
year: 2007

UnificationXref3705
type: UnificationXref
id: REACT_87767
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87767.9

RelationshipXref366
type: RelationshipXref
id: 4231870
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231870

SequenceSite333
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref3704
type: UnificationXref
id: 4232241
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232241

RelationshipXref367
type: RelationshipXref
id: GO:0004641
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite332
type: SequenceSite
position status: EQUAL
sequence position: 253

UnificationXref3707
type: UnificationXref
id: 391232
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=391232

RelationshipXref368
type: RelationshipXref
id: 4231865
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231865

SequenceSite331
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref3706
type: UnificationXref
id: 4232242
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232242

RelationshipXref369
type: RelationshipXref
id: GO:0004638
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite330
type: SequenceSite
position status: EQUAL
sequence position: 254

UnificationXref3709
type: UnificationXref
id: CHEBI:17407
db: ChEBI

UnificationXref3708
type: UnificationXref
id: REACT_17066
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17066.2

http://identifiers.org/pubmed/7538665
type: PublicationXref
id: 7538665
author: Frigeri, A
author: Turck, CW
author: Gropper, MA
author: Verkman, AS
db: Pubmed
title: Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes
source: Proc Natl Acad Sci U S A 92:4328-31
year: 1995

RelationshipXref360
type: RelationshipXref
id: 4231880
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231880

SequenceSite339
type: SequenceSite
position status: EQUAL
sequence position: 25

RelationshipXref361
type: RelationshipXref
id: GO:0004637
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite338
type: SequenceSite
position status: EQUAL
sequence position: 1178

RelationshipXref362
type: RelationshipXref
id: 4231874
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231874

SequenceSite337
type: SequenceSite
position status: EQUAL
sequence position: 21

RelationshipXref363
type: RelationshipXref
id: GO:0004644
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite336
type: SequenceSite
position status: EQUAL
sequence position: 531

http://identifiers.org/pubmed/182209
type: PublicationXref
id: 182209
author: Fersht, AR
author: Kaethner, MM
db: Pubmed
title: Enzyme hyperspecificity. Rejection of threonine by the valyl-tRNA synthetase by misacylation and hydrolytic editing
source: Biochemistry 15:3342-6
year: 1976

UnificationXref3733
type: UnificationXref
id: REACT_112167
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112167.8

UnificationXref3734
type: UnificationXref
id: 4233343
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233343

UnificationXref3731
type: UnificationXref
id: 4231760
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231760

UnificationXref3732
type: UnificationXref
id: 4231762
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231762

http://identifiers.org/pubmed/19379690
type: PublicationXref
id: 19379690
author: Kopan, R
author: Ilagan, Ma Xenia
db: Pubmed
title: The canonical Notch signaling pathway: unfolding the activation mechanism
source: Cell 137:216-33
year: 2009

UnificationXref3730
type: UnificationXref
id: REACT_5076
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5076.2

RelationshipXref339
type: RelationshipXref
id: 4232991
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232991

RelationshipXref337
type: RelationshipXref
id: GO:0006112
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite340
type: SequenceSite
position status: EQUAL
sequence position: 338

RelationshipXref338
type: RelationshipXref
id: GO:0003934
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref335
type: RelationshipXref
id: GO:0005999
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite342
type: SequenceSite
position status: EQUAL
sequence position: 30

UnificationXref3739
type: UnificationXref
id: 158601
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158601

RelationshipXref336
type: RelationshipXref
id: GO:0031325
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite341
type: SequenceSite
position status: EQUAL
sequence position: 279

UnificationXref3738
type: UnificationXref
id: CHEBI:17200
db: ChEBI

RelationshipXref333
type: RelationshipXref
id: 4233232
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233232

SequenceSite344
type: SequenceSite
position status: EQUAL
sequence position: 279

UnificationXref3737
type: UnificationXref
id: REACT_115263
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115263.8

RelationshipXref334
type: RelationshipXref
id: GO:0006744
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite343
type: SequenceSite
position status: EQUAL
sequence position: 430

UnificationXref3736
type: UnificationXref
id: 4233344
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233344

RelationshipXref331
type: RelationshipXref
id: 4233250
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233250

SequenceSite346
type: SequenceSite
position status: EQUAL
sequence position: 430

UnificationXref3735
type: UnificationXref
id: REACT_114164
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114164.8

RelationshipXref332
type: RelationshipXref
id: GO:0044596
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite345
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite348
type: SequenceSite
position status: EQUAL
sequence position: 413

RelationshipXref330
type: RelationshipXref
id: GO:0043430
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite347
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/3029074
type: PublicationXref
id: 3029074
author: Williams, SR
author: McIvor, RS
author: Gekeler, V
author: Martin, Jr, DW
db: Pubmed
title: A human purine nucleoside phosphorylase deficiency caused by a single base change
source: J Biol Chem 262:2332-2338
year: 1987

SequenceSite349
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/6122208
type: PublicationXref
id: 6122208
author: Meister, A
author: Anderson, ME
author: Allison, RD
db: Pubmed
title: Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids
source: Proc Natl Acad Sci U S A 79:1088-91
year: 1982

UnificationXref3720
type: UnificationXref
id: REACT_98999
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98999.9

UnificationXref3721
type: UnificationXref
id: 4233419
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233419

UnificationXref3722
type: UnificationXref
id: REACT_79998
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79998.9

UnificationXref3723
type: UnificationXref
id: 113539
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113539

UnificationXref3729
type: UnificationXref
id: 29416
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29416

RelationshipXref346
type: RelationshipXref
id: GO:0004776
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite353
type: SequenceSite
position status: EQUAL
sequence position: 681

UnificationXref3728
type: UnificationXref
id: REACT_156822
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156822.3

RelationshipXref347
type: RelationshipXref
id: 4231765
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231765

SequenceSite352
type: SequenceSite
position status: EQUAL
sequence position: 562

RelationshipXref348
type: RelationshipXref
id: GO:0004775
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite351
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/1678251
type: PublicationXref
id: 1678251
author: Tønnesen, T
author: von Figura, K
author: Gieselmann, V
author: Fluharty, AL
db: Pubmed
title: Mutations in the arylsulfatase A pseudodeficiency allele causing metachromatic leukodystrophy
source: Am J Hum Genet 49:407-13
year: 1991

RelationshipXref349
type: RelationshipXref
id: 4231622
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231622

SequenceSite350
type: SequenceSite
position status: EQUAL
sequence position: 413

UnificationXref3725
type: UnificationXref
id: P27550
db: UniProt

RelationshipXref342
type: RelationshipXref
id: GO:0050999
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite357
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref3724
type: UnificationXref
id: REACT_4732
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4732.2

RelationshipXref343
type: RelationshipXref
id: GO:0046209
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite356
type: SequenceSite
position status: EQUAL
sequence position: 681

http://identifiers.org/pubmed/6434534
type: PublicationXref
id: 6434534
author: Gracy, RW
author: Yuan, PM
author: Lu, HS
db: Pubmed
title: Primary structure of human triosephosphate isomerase
source: J Biol Chem 259:11958-68
year: 1984

UnificationXref3727
type: UnificationXref
id: 4232681
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232681

RelationshipXref344
type: RelationshipXref
id: GO:0034602
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite355
type: SequenceSite
position status: EQUAL
sequence position: 843

UnificationXref3726
type: UnificationXref
id: 4232679
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232679

RelationshipXref345
type: RelationshipXref
id: 4231653
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231653

SequenceSite354
type: SequenceSite
position status: EQUAL
sequence position: 2

RelationshipXref340
type: RelationshipXref
id: GO:0004146
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite359
type: SequenceSite
position status: EQUAL
sequence position: 2

RelationshipXref341
type: RelationshipXref
id: 4233017
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233017

SequenceSite358
type: SequenceSite
position status: EQUAL
sequence position: 843

http://identifiers.org/pubmed/7354069
type: PublicationXref
id: 7354069
author: Anderson, PM
author: Desnick, RJ
db: Pubmed
title: Purification and properties of uroporphyrinogen I synthase from human erythrocytes. Identification of stable enzyme-substrate intermediates.
source: J Biol Chem 255:1993-9
year: 1980

Depurination
type: Pathway
data source: Provenance1
pathway component: REACT 104029.9
pathway component: REACT 83025.9
evidence: Evidence32
xref: UnificationXref274
xref: RelationshipXref20
xref: UnificationXref273
pathway order: PathwayStep26
pathway order: PathwayStep24
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/12372849
type: PublicationXref
id: 12372849
author: Strott, CA
db: Pubmed
title: Sulfonation and molecular action
source: Endocr Rev 23:703-32
year: 2002

SequenceSite369
type: SequenceSite
position status: EQUAL
sequence position: 2

RelationshipXref310
type: RelationshipXref
id: GO:0004602
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite367
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite368
type: SequenceSite
position status: EQUAL
sequence position: 348

RelationshipXref312
type: RelationshipXref
id: GO:0019372
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite365
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref311
type: RelationshipXref
id: 4233223
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233223

SequenceSite366
type: SequenceSite
position status: EQUAL
sequence position: 379

RelationshipXref314
type: RelationshipXref
id: GO:0036185
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite363
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref313
type: RelationshipXref
id: 4233218
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233218

SequenceSite364
type: SequenceSite
position status: EQUAL
sequence position: 392

RelationshipXref316
type: RelationshipXref
id: GO:2001300
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite361
type: SequenceSite
position status: EQUAL
sequence position: 2

RelationshipXref315
type: RelationshipXref
id: 4233220
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233220

SequenceSite362
type: SequenceSite
position status: EQUAL
sequence position: 842

RelationshipXref317
type: RelationshipXref
id: GO:0019369
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite360
type: SequenceSite
position status: EQUAL
sequence position: 842

RelationshipXref318
type: RelationshipXref
id: GO:0004098
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref319
type: RelationshipXref
id: 4233040
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233040

http://identifiers.org/pubmed/10229653
type: PublicationXref
id: 10229653
author: Wallace, JC
author: Jitrapakdee, S
db: Pubmed
title: Structure, function and regulation of pyruvate carboxylase
source: Biochem J 340:1-16
year: 1999

UniProt:P00490
type: ProteinReference
xref: UnificationXref1626
organism: BioSource1

RelationshipXref323
type: RelationshipXref
id: GO:0006665
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite376
type: SequenceSite
position status: EQUAL
sequence position: 337

RelationshipXref322
type: RelationshipXref
id: GO:0006687
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite377
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/7354072
type: PublicationXref
id: 7354072
author: Bodlaender, P
author: Shemin, D
author: Bevan, DR
db: Pubmed
title: Mechanism of porphobilinogen synthase. Requirement of Zn2+ for enzyme activity.
source: J Biol Chem 255:2030-5
year: 1980

RelationshipXref321
type: RelationshipXref
id: 4233048
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233048

SequenceSite378
type: SequenceSite
position status: EQUAL
sequence position: 337

RelationshipXref320
type: RelationshipXref
id: GO:0004773
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite379
type: SequenceSite
position status: EQUAL
sequence position: 1

Triacylglycerol biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction150
pathway component: BiochemicalReaction151
pathway component: BiochemicalReaction149
evidence: Evidence288
xref: UnificationXref1835
xref: RelationshipXref235
xref: UnificationXref1834
pathway order: PathwayStep272
pathway order: PathwayStep273
pathway order: PathwayStep274
display name: Triglyceride Biosynthesis
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref327
type: RelationshipXref
id: 4233245
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233245

SequenceSite372
type: SequenceSite
position status: EQUAL
sequence position: 483

RelationshipXref326
type: RelationshipXref
id: GO:0016709
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite373
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref325
type: RelationshipXref
id: 4233255
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233255

SequenceSite374
type: SequenceSite
position status: EQUAL
sequence position: 228

RelationshipXref324
type: RelationshipXref
id: GO:0002083
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite375
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref328
type: RelationshipXref
id: GO:0044595
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite371
type: SequenceSite
position status: EQUAL
sequence position: 2

RelationshipXref329
type: RelationshipXref
id: 4233257
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233257

SequenceSite370
type: SequenceSite
position status: EQUAL
sequence position: 515

http://identifiers.org/pubmed/11575290
type: PublicationXref
id: 11575290
author: Bell, GI
author: Fajans, SS
author: Polonsky, KS
db: Pubmed
title: Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young
source: N Engl J Med 345:971-80
year: 2001

Double-strand DNA containing a dihydrouracil
type: PhysicalEntity
data source: Provenance1
xref: UnificationXref295
cellular location: intracellular
comment: Reactome DB_ID: 4230322

Double-strand DNA containing a cytosine glycol
type: PhysicalEntity
data source: Provenance1
xref: UnificationXref289
cellular location: intracellular
comment: Reactome DB_ID: 4230316

Double-strand DNA containing an ethenocytosine
type: PhysicalEntity
data source: Provenance1
xref: UnificationXref277
cellular location: intracellular
comment: Reactome DB_ID: 4232064

SequenceSite385
type: SequenceSite
position status: EQUAL
sequence position: 1

DNA containing an apurinic/apyrimidinic (AP) site
type: PhysicalEntity
data source: Provenance1
xref: UnificationXref267
cellular location: intracellular
comment: Reactome DB_ID: 4230329

SequenceSite386
type: SequenceSite
position status: EQUAL
sequence position: 288

Double-strand DNA containing an uracil opposite to a guanine
type: PhysicalEntity
data source: Provenance1
xref: UnificationXref285
cellular location: intracellular
comment: Reactome DB_ID: 4232056

SequenceSite383
type: SequenceSite
position status: EQUAL
sequence position: 1

PublicationXref770
type: PublicationXref
id: 978-0-444-53219-0
author: Vance, DE
author: Vance, JE
db: ISBN
title: Phospholipid biosynthesis in eukaryotes
source: Biochemistry of Lipids, Lipoproteins and Membranes, 5th Edition (Book): 213-244
year: 2008

Double-strand DNA containing a thymine opposite to a guanine
type: PhysicalEntity
data source: Provenance1
xref: UnificationXref281
cellular location: intracellular
display name: dsDNA with T:G mismatch
comment: Reactome DB_ID: 4232052

SequenceSite384
type: SequenceSite
position status: EQUAL
sequence position: 277

UniProt:P31826
type: ProteinReference
xref: UnificationXref367
organism: BioSource1

Excitatory amino acid transporters
type: PhysicalEntity
data source: Provenance1
xref: UnificationXref56
cellular location: plasma membrane
display name: EAATs
comment: Reactome DB_ID: 4232544
comment: Converted from EntitySet in Reactome
member physical entity: Protein1
member physical entity: Protein7
member physical entity: Protein13
member physical entity: Protein4
member physical entity: Protein10

SequenceSite389
type: SequenceSite
position status: EQUAL
sequence position: 1

Double-strand DNA containing an adenine opposite to an 8-oxo guanine
type: PhysicalEntity
data source: Provenance1
xref: UnificationXref255
cellular location: intracellular
comment: Reactome DB_ID: 4230340

SequenceSite387
type: SequenceSite
position status: EQUAL
sequence position: 649

VGLUTs
type: PhysicalEntity
data source: Provenance1
xref: UnificationXref86
cellular location: intracellular
comment: Reactome DB_ID: 4232570
comment: Converted from EntitySet in Reactome
member physical entity: Protein26
member physical entity: Protein21
member physical entity: Protein16

SequenceSite388
type: SequenceSite
position status: EQUAL
sequence position: 650

SequenceSite382
type: SequenceSite
position status: EQUAL
sequence position: 318

SequenceSite381
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite380
type: SequenceSite
position status: EQUAL
sequence position: 237

UniProt:P0ABQ4
type: ProteinReference
xref: UnificationXref1226
organism: BioSource1

2'-deoxyuridine 5'-triphosphate
type: SmallMoleculeReference
name: dUTP [ChEBI:17625]
name: dUTP
xref: UnificationXref2931

Protoheme
type: SmallMoleculeReference
name: Ferroheme
name: Heme
name: ChEBI:17627 Heme
name: Haem
xref: UnificationXref2885

RelationshipXref305
type: RelationshipXref
id: GO:0097257
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite394
type: SequenceSite
position status: EQUAL
sequence position: 559

RelationshipXref304
type: RelationshipXref
id: 4232350
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232350

SequenceSite395
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref303
type: RelationshipXref
id: GO:0004463
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite396
type: SequenceSite
position status: EQUAL
sequence position: 828

RelationshipXref302
type: RelationshipXref
id: GO:0019371
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite397
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref301
type: RelationshipXref
id: 4233211
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233211

SequenceSite398
type: SequenceSite
position status: EQUAL
sequence position: 283

RelationshipXref300
type: RelationshipXref
id: GO:0036132
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite399
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:P0ABQ0
type: ProteinReference
xref: UnificationXref3164
organism: BioSource1

Synthesis of 15-eicosatetraenoic acid derivatives
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction194
evidence: Evidence369
xref: RelationshipXref312
xref: UnificationXref2373
xref: UnificationXref2372
pathway order: PathwayStep355
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref308
type: RelationshipXref
id: 4232344
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232344

SequenceSite391
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/6450420
type: PublicationXref
id: 6450420
author: Kresse, H
author: von Figura, K
author: Paschke, E
author: Fuchs, W
author: Gilberg, W
db: Pubmed
title: Sanfilippo disease type D: deficiency of N-acetylglucosamine-6-sulfate sulfatase required for heparan sulfate degradation
source: Proc Natl Acad Sci U S A 77:6822-6
year: 1980

RelationshipXref309
type: RelationshipXref
id: GO:0006691
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite390
type: SequenceSite
position status: EQUAL
sequence position: 1076

Carubinose
type: SmallMoleculeReference
name: D-Mannose
name: D-Mannose [ChEBI:4208]
name: Mannose
name: Seminose
xref: UnificationXref485

RelationshipXref306
type: RelationshipXref
id: 4233203
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233203

SequenceSite393
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref307
type: RelationshipXref
id: GO:0003840
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite392
type: SequenceSite
position status: EQUAL
sequence position: 1076

2'-Deoxyuridine 5'-phosphate
type: SmallMoleculeReference
name: Deoxyuridine monophosphate
name: dUMP
name: Deoxyuridylic acid
name: dUMP [ChEBI:17622]
name: Deoxyuridine 5'-phosphate
xref: UnificationXref2938

FMN [ChEBI:17621]
type: SmallMoleculeReference
name: FMN
name: Riboflavin-5-phosphate
name: Flavin mononucleotide
xref: UnificationXref2912

PublicationXref759
type: PublicationXref
author: Marmer, WN
author: Piazza, GJ
title: Conversion of Phosphatidylcholine to Phosphatidylglycerol with Phospholipase D and glycerol
source: J. Amer. Oil Chem. Soc. 84:6465-651
year: 2007

UnificationXref1417
type: UnificationXref
id: REACT_148726
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148726.4

UnificationXref1416
type: UnificationXref
id: 4233411
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233411

UnificationXref1415
type: UnificationXref
id: REACT_149216
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149216.4

UnificationXref1414
type: UnificationXref
id: 4233407
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233407

http://identifiers.org/pubmed/9839614
type: PublicationXref
id: 9839614
author: Farr, C
author: Menzel, EJ
db: Pubmed
title: Hyaluronidase and its substrate hyaluronan: biochemistry, biological activities and therapeutic uses
source: Cancer Lett 131:3-11
year: 1998

UnificationXref1419
type: UnificationXref
id: REACT_149129
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149129.4

UnificationXref1418
type: UnificationXref
id: 4233406
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233406

Myristoyl-CoA
type: SmallMoleculeReference
name: Tetradecanoyl-CoA [ChEBI:15532]
name: Tetradecanoyl-CoA
xref: UnificationXref1856

Octanoyl-CoA
type: SmallMoleculeReference
name: Octanoyl-CoA [ChEBI:15533]
xref: UnificationXref1915

Carbamoyl phosphate [ChEBI:17672]
type: SmallMoleculeReference
name: Carbamoyl phosphate
xref: UnificationXref3479

UnificationXref1412
type: UnificationXref
id: 4233404
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233404

UnificationXref1413
type: UnificationXref
id: REACT_149177
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149177.4

UnificationXref1410
type: UnificationXref
id: 4233412
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233412

UnificationXref1411
type: UnificationXref
id: REACT_148756
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148756.4

UnificationXref1404
type: UnificationXref
id: 4233400
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233400

http://identifiers.org/pubmed/3327432
type: PublicationXref
id: 3327432
author: Kapoor, S
author: Seaman, C
author: Piomelli, S
db: Pubmed
title: Lead-induced abnormalities of porphyrin metabolism. The relationship with iron deficiency.
source: Ann N Y Acad Sci 514:278-88
year: 1987

UnificationXref1403
type: UnificationXref
id: REACT_136260
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136260.5

UnificationXref1406
type: UnificationXref
id: 4233410
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233410

UnificationXref1405
type: UnificationXref
id: REACT_127689
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127689.5

Transport of Glycerol from Adipocytes to the Liver by Aquaporins
type: Pathway
data source: Provenance1
pathway component: Passive Transport of Glycerol out of Cell by Aquaporin-7
pathway component: Passive Transport of Glycerol into Cell by Aquaporin-9
evidence: Evidence108
xref: RelationshipXref79
xref: UnificationXref734
xref: UnificationXref733
pathway order: PathwayStep100
pathway order: PathwayStep101
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1408
type: UnificationXref
id: 4233409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233409

UnificationXref1407
type: UnificationXref
id: REACT_149347
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149347.4

(5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate
type: SmallMoleculeReference
name: (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate [ChEBI:247]
xref: UnificationXref2274

UnificationXref1409
type: UnificationXref
id: REACT_148715
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148715.4

UnificationXref1400
type: UnificationXref
id: 4233514
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233514

UnificationXref1401
type: UnificationXref
id: REACT_140402
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140402.5

UnificationXref1402
type: UnificationXref
id: 4233515
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233515

UnificationXref1439
type: UnificationXref
id: 4232198
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232198

Butanoyl-CoA
type: SmallMoleculeReference
name: Butanoyl-CoA [ChEBI:15517]
xref: UnificationXref1951

UnificationXref1438
type: UnificationXref
id: MOD:00171
db: MOD

UDP
type: SmallMoleculeReference
name: uridine 5'-diphosphate
name: uridine 5'-diphosphate [ChEBI:17659]
xref: UnificationXref1085

UnificationXref1437
type: UnificationXref
id: P13482
db: UniProt

Choloyl-CoA [ChEBI:15519]
type: SmallMoleculeReference
name: Choloyl-CoA
xref: UnificationXref2146

UnificationXref1436
type: UnificationXref
id: REACT_9619
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9619.1

UnificationXref1434
type: UnificationXref
id: CHEBI:16551
db: ChEBI

UnificationXref1435
type: UnificationXref
id: 189078
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189078

UnificationXref1432
type: UnificationXref
id: 4233403
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233403

UnificationXref1433
type: UnificationXref
id: REACT_146414
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146414.5

UnificationXref1430
type: UnificationXref
id: 4233548
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233548

UnificationXref1431
type: UnificationXref
id: REACT_162441
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_162441.2

UnificationXref1429
type: UnificationXref
id: REACT_149737
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149737.4

Palmitoyl-CoA
type: SmallMoleculeReference
name: Palmitoyl-CoA [ChEBI:15525]
name: Hexadecanoyl-CoA
xref: UnificationXref2103

Glutaryl-CoA [ChEBI:15524]
type: SmallMoleculeReference
name: Glutaryl-CoA
xref: UnificationXref3443

UnificationXref1426
type: UnificationXref
id: 4233401
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233401

UnificationXref1425
type: UnificationXref
id: REACT_148882
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148882.4

UnificationXref1428
type: UnificationXref
id: 4233402
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233402

UnificationXref1427
type: UnificationXref
id: REACT_149729
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149729.4

alpha-D-Glucose 6-phosphate
type: SmallMoleculeReference
name: alpha-D-Glucose 6-phosphate [ChEBI:17665]
xref: UnificationXref1447

UnificationXref1421
type: UnificationXref
id: REACT_149060
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149060.4

UnificationXref1422
type: UnificationXref
id: 4233405
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233405

PublicationXref717
type: PublicationXref
id: 0716720094
author: Stryer, L
db: ISBN
title: 21: Oxidative Phosphorylation
source: Biochemistry, 4th ed (Book): 548-549
year: 1995

UnificationXref1423
type: UnificationXref
id: REACT_149817
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149817.4

UnificationXref1424
type: UnificationXref
id: 4233408
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233408

Formyl-CoA [ChEBI:5150]
type: SmallMoleculeReference
name: Formyl-CoA
xref: UnificationXref2058

Lauroyl-CoA
type: SmallMoleculeReference
name: Dodecanoyl-CoA
name: Lauroyl coenzyme A
name: Lauroyl-CoA [ChEBI:15521]
xref: UnificationXref1876

UnificationXref1420
type: UnificationXref
id: 4233413
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233413

Tryptophan catabolism
type: Pathway
data source: Provenance1
pathway component: kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate
evidence: Evidence529
xref: UnificationXref3477
xref: RelationshipXref514
xref: UnificationXref3478
pathway order: PathwayStep516
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref363
type: UnificationXref
id: REACT_2741
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2741.1

UnificationXref364
type: UnificationXref
id: GO:0005782
db: GENE ONTOLOGY

UnificationXref361
type: UnificationXref
id: CHEBI:16761
db: ChEBI

UnificationXref362
type: UnificationXref
id: 29370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370

Cobalamin (Cbl, vitamin B12) transport and metabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction168
pathway component: BiochemicalReaction276
evidence: Evidence483
xref: RelationshipXref455
xref: UnificationXref3213
xref: UnificationXref3214
pathway order: PathwayStep469
pathway order: PathwayStep301
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Lens fiber major intrinsic protein (AQP0) tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry46
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref634
cellular location: plasma membrane
comment: Reactome DB_ID: 4232706

Aquaporins that transport water across the plasma membrane.
type: Complex
data source: Provenance1
member physical entity: AQP10 tetramer (name copied from entity in Homo sapiens)
member physical entity: AQP5 tetramer (name copied from entity in Homo sapiens)
member physical entity: AQP4 tetramer (name copied from entity in Homo sapiens)
member physical entity: AQP1 tetramer (name copied from entity in Homo sapiens)
member physical entity: AQP9 tetramer (name copied from entity in Homo sapiens)
member physical entity: p-S256-AQP2 (name copied from entity in Homo sapiens)
member physical entity: AQP7 tetramer (name copied from entity in Homo sapiens)
member physical entity: AQP3 tetramer (name copied from entity in Homo sapiens)
member physical entity: Lens fiber major intrinsic protein (AQP0) tetramer (name copied from entity in Homo sapiens)
member physical entity: Aquaporin-8 tetramer (name copied from entity in Homo sapiens)
name: AQP0 (MIP), AQP1, p-AQP2, AQP3, AQP4, AQP5, AQP7, AQP8, AQP9, AQP10, AQP11
name: Aquaporin-0, Aquaporin-1, Phospho-Aquaporin-2, Aquaporin-3, Aquaporin-4, Aquaporin-5, Aquaporin-7, Aquaporin-8, Aquaporin-9, Aquaporin-10, Aquaporin-11
xref: UnificationXref655
cellular location: plasma membrane
display name: AQP0/1/2/3/4/5/7/8/9/10/11
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232713

UnificationXref360
type: UnificationXref
id: REACT_2812
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2812.1

AQP1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry47
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref636
cellular location: plasma membrane
comment: Reactome DB_ID: 4232625

UnificationXref2318
type: UnificationXref
id: REACT_150859
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150859.1

UnificationXref2319
type: UnificationXref
id: 4233204
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233204

UnificationXref2316
type: UnificationXref
id: CHEBI:27814
db: ChEBI

UnificationXref369
type: UnificationXref
id: 4232459
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232459

UnificationXref2317
type: UnificationXref
id: 2142810
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142810

UnificationXref367
type: UnificationXref
id: P31826
db: UniProt

UnificationXref368
type: UnificationXref
id: 4232458
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232458

UnificationXref365
type: UnificationXref
id: 382571
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=382571

UnificationXref366
type: UnificationXref
id: REACT_16090
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16090.2

UnificationXref2311
type: UnificationXref
id: P04825
db: UniProt

UnificationXref2310
type: UnificationXref
id: REACT_17747
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17747.2

UniProt:P37146
type: ProteinReference
xref: UnificationXref1228
organism: BioSource1

UnificationXref2315
type: UnificationXref
id: REACT_156239
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156239.3

UnificationXref1382
type: UnificationXref
id: 4233026
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233026

UnificationXref2314
type: UnificationXref
id: 4232351
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232351

UnificationXref1383
type: UnificationXref
id: 4233027
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233027

UnificationXref2313
type: UnificationXref
id: 4232349
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232349

UnificationXref1380
type: UnificationXref
id: 4233022
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233022

UnificationXref2312
type: UnificationXref
id: 4232348
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232348

UnificationXref1381
type: UnificationXref
id: P77318
db: UniProt

AQP7 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry52
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref648
cellular location: plasma membrane
comment: Reactome DB_ID: 4232650

UnificationXref1386
type: UnificationXref
id: REACT_136528
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136528.5

Aquaporin-8 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry53
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref650
cellular location: plasma membrane
comment: Reactome DB_ID: 4232710

UnificationXref1387
type: UnificationXref
id: CHEBI:63513
db: ChEBI

AQP9 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry54
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref652
cellular location: plasma membrane
comment: Reactome DB_ID: 4232636

UnificationXref1384
type: UnificationXref
id: 4233028
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233028

AQP10 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry55
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref654
cellular location: plasma membrane
comment: Reactome DB_ID: 4232712

UnificationXref1385
type: UnificationXref
id: 4233030
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233030

p-S256-AQP2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry48
component: phospho-p-S256-AQP2
xref: UnificationXref639
cellular location: plasma membrane
comment: Reactome DB_ID: 4232642

AQP3 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry49
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref642
cellular location: plasma membrane
comment: Reactome DB_ID: 4232676

AQP4 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry50
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref644
cellular location: plasma membrane
comment: Reactome DB_ID: 4232646

UnificationXref1388
type: UnificationXref
id: 2065210
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2065210

AQP5 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry51
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref646
cellular location: plasma membrane
comment: Reactome DB_ID: 4232708

UnificationXref1389
type: UnificationXref
id: REACT_125557
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125557.1

UnificationXref372
type: UnificationXref
id: 4232462
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232462

UnificationXref373
type: UnificationXref
id: 4232463
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232463

UnificationXref374
type: UnificationXref
id: 4232464
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232464

UnificationXref375
type: UnificationXref
id: 4232465
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232465

http://identifiers.org/pubmed/8382952
type: PublicationXref
id: 8382952
author: Pugh, EN
author: Lamb, TD
db: Pubmed
title: Amplification and kinetics of the activation steps in phototransduction
source: Biochim. Biophys. Acta 1141:111-49
year: 1993

UnificationXref370
type: UnificationXref
id: 4232460
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232460

UnificationXref371
type: UnificationXref
id: 4232461
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232461

UnificationXref2327
type: UnificationXref
id: P18956
db: UniProt

UnificationXref2328
type: UnificationXref
id: 4232338
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232338

UnificationXref2329
type: UnificationXref
id: 4232337
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232337

UnificationXref376
type: UnificationXref
id: 4232467
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232467

UnificationXref377
type: UnificationXref
id: REACT_112344
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112344.8

UniProt:P0AEZ1
type: ProteinReference
xref: UnificationXref3302
organism: BioSource1

UnificationXref378
type: UnificationXref
id: 4233443
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233443

UnificationXref379
type: UnificationXref
id: REACT_114103
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114103.8

UnificationXref2320
type: UnificationXref
id: REACT_157720
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157720.3

UnificationXref2322
type: UnificationXref
id: 266013
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266013

UnificationXref2321
type: UnificationXref
id: CHEBI:16978
db: ChEBI

UnificationXref1390
type: UnificationXref
id: CHEBI:63512
db: ChEBI

http://identifiers.org/pubmed/18772396
type: PublicationXref
id: 18772396
author: Zhang, X
author: Shinjo, SM
author: Rasheed, BA
author: Lin, JC
author: Carter, H
author: Jones, S
author: Keir, S
author: Parmigiani, G
author: Yan, H
author: McLendon, R
author: Olivi, A
author: Nikolsky, Y
author: Diaz Jr, LA
author: Tekleab, H
author: Vogelstein, B
author: Kinzler, KW
author: Velculescu, VE
author: Papadopoulos, N
author: Mankoo, P
author: Marie, SK
author: Parsons, DW
author: Busam, DA
author: Riggins, GJ
author: Bigner, DD
author: Karchin, R
author: Hartigan, J
author: Angenendt, P
author: Leary, RJ
author: Smith, DR
author: Strausberg, RL
author: Gallia, GL
author: Siu, IM
author: Nikolskaya, T
db: Pubmed
title: An integrated genomic analysis of human glioblastoma multiforme
source: Science 321:1807-12
year: 2008

UnificationXref2324
type: UnificationXref
id: CHEBI:28666
db: ChEBI

UnificationXref1391
type: UnificationXref
id: 2065246
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2065246

UniProt:P39398
type: ProteinReference
xref: UnificationXref67
organism: BioSource1

UnificationXref2323
type: UnificationXref
id: REACT_17252
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17252.2

UnificationXref1392
type: UnificationXref
id: REACT_124637
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124637.1

UnificationXref2326
type: UnificationXref
id: REACT_15889
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15889.2

UnificationXref1393
type: UnificationXref
id: 2065251
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2065251

UnificationXref2325
type: UnificationXref
id: 266074
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266074

UnificationXref1394
type: UnificationXref
id: REACT_122110
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122110.1

ABCD1:ABCD3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry29
component stoichiometry: Stoichiometry28
component: Protein55
component: Protein57
xref: UnificationXref373
cellular location: intracellular
comment: Reactome DB_ID: 4232463

UnificationXref1395
type: UnificationXref
id: CHEBI:63511
db: ChEBI

ABCD2:ABCD3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry30
component stoichiometry: Stoichiometry31
component: Protein56
component: Protein57
xref: UnificationXref374
cellular location: intracellular
comment: Reactome DB_ID: 4232464

UnificationXref1396
type: UnificationXref
id: 2065239
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2065239

ABCD1 homodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry25
component: Protein55
xref: UnificationXref369
cellular location: intracellular
comment: Reactome DB_ID: 4232459

UnificationXref1397
type: UnificationXref
id: REACT_122009
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122009.1

ABCD1:ABCD2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry26
component stoichiometry: Stoichiometry27
component: Protein56
component: Protein55
xref: UnificationXref371
cellular location: intracellular
comment: Reactome DB_ID: 4232461

UnificationXref1398
type: UnificationXref
id: 4233166
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233166

DNA containing a hNTH1-bound apurinic/apyrimidinic site (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry24
component stoichiometry: Stoichiometry23
component: DNA containing an apurinic/apyrimidinic (AP) site
component: Protein54
xref: UnificationXref321
cellular location: intracellular
comment: Reactome DB_ID: 4232076

UnificationXref1399
type: UnificationXref
id: REACT_138315
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138315.5

ABCD1/2/3 dimers
type: Complex
data source: Provenance1
member physical entity: ABCD1:ABCD3 (name copied from entity in Homo sapiens)
member physical entity: ABCD1:ABCD2 (name copied from entity in Homo sapiens)
member physical entity: ABCD1 homodimer (name copied from entity in Homo sapiens)
member physical entity: ABCD2:ABCD3 (name copied from entity in Homo sapiens)
xref: UnificationXref375
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232465

DNA containing a TDG-bound apurinic/apyrimidinic site (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry22
component stoichiometry: Stoichiometry21
component: DNA containing an apurinic/apyrimidinic (AP) site
component: Protein53
xref: UnificationXref312
cellular location: intracellular
comment: Reactome DB_ID: 4232073

http://identifiers.org/pubmed/15845384
type: PublicationXref
id: 15845384
author: Ohira, RH
author: Dipple, KM
author: McCabe, ER
author: Zhang, YH
db: Pubmed
title: Human and murine glycerol kinase: influence of exon 18 alternative splicing on function
source: Biochem Biophys Res Commun 331:239-46
year: 2005

UnificationXref341
type: UnificationXref
id: REACT_32470
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32470.10

UnificationXref342
type: UnificationXref
id: 4233380
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233380

UnificationXref340
type: UnificationXref
id: 4232082
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232082

UnificationXref345
type: UnificationXref
id: REACT_87272
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87272.9

UnificationXref346
type: UnificationXref
id: 4233377
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233377

http://identifiers.org/pubmed/10978532
type: PublicationXref
id: 10978532
author: Cregeen, DP
author: Williams, EL
author: Rumsby, G
db: Pubmed
title: Identification and expression of a cDNA for human glycolate oxidase
source: Biochim Biophys Acta 1493:246-8
year: 2000

UnificationXref343
type: UnificationXref
id: REACT_110913
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_110913.9

UnificationXref344
type: UnificationXref
id: 4233376
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233376

UnificationXref349
type: UnificationXref
id: REACT_94942
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94942.9

UnificationXref347
type: UnificationXref
id: REACT_93955
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93955.9

UnificationXref348
type: UnificationXref
id: 4233378
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233378

UnificationXref1360
type: UnificationXref
id: REACT_123293
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123293.1

http://identifiers.org/pubmed/10930435
type: PublicationXref
id: 10930435
author: Toole, BP
db: Pubmed
title: Hyaluronan is not just a goo!
source: J Clin Invest 106:335-6
year: 2000

UnificationXref1361
type: UnificationXref
id: 4233157
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233157

http://identifiers.org/pubmed/11668611
type: PublicationXref
id: 11668611
author: Hopwood, JJ
author: Yogalingam, G
db: Pubmed
title: Molecular genetics of mucopolysaccharidosis type IIIA and IIIB: Diagnostic, clinical, and biological implications
source: Hum Mutat 18:264-81
year: 2001

UniProt:P39389
type: ProteinReference
xref: UnificationXref3433
organism: BioSource1

http://identifiers.org/pubmed/18388293
type: PublicationXref
id: 18388293
author: Kumar, R
author: An, S
author: Benkovic, SJ
author: Sheets, ED
db: Pubmed
title: Reversible compartmentalization of de novo purine biosynthetic complexes in living cells
source: Science 320:103-6
year: 2008

UnificationXref1368
type: UnificationXref
id: 4233523
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233523

UnificationXref1369
type: UnificationXref
id: REACT_136138
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136138.5

UnificationXref1366
type: UnificationXref
id: 4233522
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233522

UnificationXref1367
type: UnificationXref
id: REACT_131333
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131333.5

UnificationXref1364
type: UnificationXref
id: 427963
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=427963

UnificationXref1365
type: UnificationXref
id: REACT_20458
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20458.2

UnificationXref1362
type: UnificationXref
id: REACT_147358
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147358.5

UnificationXref1363
type: UnificationXref
id: 4233158
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233158

http://identifiers.org/pubmed/2040271
type: PublicationXref
id: 2040271
author: Sadahiro, S
author: Matsuda, T
author: Takenaka, M
author: Tanaka, T
author: Noguchi, T
author: Hirai, H
author: Imai, E
author: Yamada, K
db: Pubmed
title: Isolation and characterization of the human pyruvate kinase M gene
source: Eur J Biochem 198:101-6
year: 1991

UnificationXref350
type: UnificationXref
id: 4233379
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233379

http://identifiers.org/pubmed/16005139
type: PublicationXref
id: 16005139
author: Veiga-da-Cunha, M
author: Rzem, R
author: Van Schaftingen, E
db: Pubmed
title: The gene mutated in l-2-hydroxyglutaric aciduria encodes l-2-hydroxyglutarate dehydrogenase
source: Biochimie 88:113-6
year: 2006

UnificationXref351
type: UnificationXref
id: REACT_83660
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83660.9

UnificationXref352
type: UnificationXref
id: CHEBI:15377
db: ChEBI

UnificationXref353
type: UnificationXref
id: 29356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356

http://identifiers.org/pubmed/1463457
type: PublicationXref
id: 1463457
author: Morris, CP
author: Hopwood, JJ
author: Robertson, DA
author: Freeman, C
db: Pubmed
title: A cDNA clone for human glucosamine-6-sulphatase reveals differences between arylsulphatases and non-arylsulphatases
source: Biochem J 288:539-44
year: 1992

UnificationXref2309
type: UnificationXref
id: 266056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266056

UnificationXref354
type: UnificationXref
id: REACT_3683
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3683.1

http://identifiers.org/pubmed/16839620
type: PublicationXref
id: 16839620
author: Kushner, JP
author: Phillips, JD
author: Ajioka, RS
db: Pubmed
title: Biosynthesis of heme in mammals
source: Biochim Biophys Acta 1763:723-36
year: 2006

UnificationXref355
type: UnificationXref
id: CHEBI:15904
db: ChEBI

UnificationXref356
type: UnificationXref
id: 382577
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=382577

UnificationXref357
type: UnificationXref
id: REACT_16095
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16095.2

UnificationXref2305
type: UnificationXref
id: CHEBI:15651
db: ChEBI

UnificationXref358
type: UnificationXref
id: CHEBI:15422
db: ChEBI

UnificationXref2306
type: UnificationXref
id: 265281
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265281

UnificationXref359
type: UnificationXref
id: 113592
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592

UnificationXref2307
type: UnificationXref
id: REACT_15722
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15722.2

UnificationXref2308
type: UnificationXref
id: CHEBI:15647
db: ChEBI

UnificationXref2302
type: UnificationXref
id: REACT_156895
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156895.3

UnificationXref2301
type: UnificationXref
id: 4233212
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233212

UnificationXref1370
type: UnificationXref
id: CHEBI:63519
db: ChEBI

UnificationXref2304
type: UnificationXref
id: REACT_152861
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152861.3

UnificationXref1371
type: UnificationXref
id: 2065231
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2065231

UnificationXref2303
type: UnificationXref
id: 4233538
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233538

UnificationXref1372
type: UnificationXref
id: REACT_123393
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123393.1

UnificationXref2300
type: UnificationXref
id: 4233202
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233202

http://identifiers.org/pubmed/2564390
type: PublicationXref
id: 2564390
author: Van Heeke, G
author: Schuster, SM
db: Pubmed
title: Expression of human asparagine synthetase in Escherichia coli
source: J Biol Chem 264:5503-9
year: 1989

UnificationXref1377
type: UnificationXref
id: 1606834
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1606834

UnificationXref1378
type: UnificationXref
id: REACT_117466
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117466.1

UnificationXref1379
type: UnificationXref
id: P25549
db: UniProt

Insulin effects increased synthesis of Xylulose-5-Phosphate
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction138
evidence: Evidence389
xref: RelationshipXref335
xref: UnificationXref2523
xref: UnificationXref2522
pathway order: PathwayStep254
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1373
type: UnificationXref
id: CHEBI:63517
db: ChEBI

UnificationXref1374
type: UnificationXref
id: 2065213
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2065213

UnificationXref1375
type: UnificationXref
id: REACT_124370
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124370.1

UnificationXref1376
type: UnificationXref
id: CHEBI:29108
db: ChEBI

UnificationXref328
type: UnificationXref
id: 30140
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30140

UnificationXref327
type: UnificationXref
id: CHEBI:15901
db: ChEBI

UnificationXref326
type: UnificationXref
id: REACT_105635
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105635.9

UnificationXref325
type: UnificationXref
id: 4232079
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232079

UnificationXref324
type: UnificationXref
id: 4230333
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230333

UnificationXref323
type: UnificationXref
id: REACT_96277
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96277.9

UnificationXref322
type: UnificationXref
id: 4232078
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232078

UnificationXref321
type: UnificationXref
id: 4232076
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232076

UnificationXref320
type: UnificationXref
id: 4230328
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230328

UnificationXref1348
type: UnificationXref
id: 4233149
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233149

http://identifiers.org/pubmed/20919643
type: PublicationXref
id: 20919643
author: Gault, CR
author: Hannun, YA
author: Obeid, LM
db: Pubmed
title: An overview of sphingolipid metabolism: from synthesis to breakdown
source: Adv Exp Med Biol 688:1-23
year: 2010

UnificationXref1349
type: UnificationXref
id: 4233151
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233151

UnificationXref1343
type: UnificationXref
id: CHEBI:63852
db: ChEBI

UnificationXref1342
type: UnificationXref
id: REACT_123830
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123830.1

UnificationXref3480
type: UnificationXref
id: 29676
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29676

UnificationXref1341
type: UnificationXref
id: 2104995
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2104995

UnificationXref1340
type: UnificationXref
id: CHEBI:63851
db: ChEBI

UnificationXref3482
type: UnificationXref
id: CHEBI:15729
db: ChEBI

UnificationXref2350
type: UnificationXref
id: REACT_151106
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151106.1

UnificationXref1347
type: UnificationXref
id: MOD:00835
db: MOD

UnificationXref3481
type: UnificationXref
id: REACT_5535
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5535.2

UnificationXref2351
type: UnificationXref
id: P06610
db: UniProt

UnificationXref1346
type: UnificationXref
id: P31447
db: UniProt

UnificationXref3484
type: UnificationXref
id: REACT_2690
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2690.2

UnificationXref1345
type: UnificationXref
id: REACT_124809
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124809.1

UnificationXref3483
type: UnificationXref
id: 113585
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113585

UnificationXref1344
type: UnificationXref
id: 2105012
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2105012

UnificationXref3486
type: UnificationXref
id: 113567
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113567

UnificationXref2354
type: UnificationXref
id: 4231749
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231749

UnificationXref3485
type: UnificationXref
id: CHEBI:16349
db: ChEBI

UnificationXref2355
type: UnificationXref
id: 4233216
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233216

UnificationXref3488
type: UnificationXref
id: P04391
db: UniProt

UnificationXref2352
type: UnificationXref
id: MOD:00031
db: MOD

UnificationXref3487
type: UnificationXref
id: REACT_2266
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2266.2

UnificationXref2353
type: UnificationXref
id: 4231748
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231748

UnificationXref2358
type: UnificationXref
id: REACT_159670
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159670.3

UnificationXref3489
type: UnificationXref
id: 4231530
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231530

UnificationXref2359
type: UnificationXref
id: 4233541
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233541

UnificationXref2356
type: UnificationXref
id: 4233222
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233222

UnificationXref329
type: UnificationXref
id: REACT_3731
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3731.1

UnificationXref2357
type: UnificationXref
id: 4233224
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233224

UnificationXref337
type: UnificationXref
id: CHEBI:29147
db: ChEBI

UnificationXref336
type: UnificationXref
id: REACT_32931
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32931.10

UnificationXref339
type: UnificationXref
id: REACT_2487
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2487.2

UnificationXref338
type: UnificationXref
id: 110233
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110233

UnificationXref333
type: UnificationXref
id: 110228
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110228

UnificationXref332
type: UnificationXref
id: CHEBI:35877
db: ChEBI

UnificationXref335
type: UnificationXref
id: 4232081
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232081

UnificationXref334
type: UnificationXref
id: REACT_4993
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4993.2

UnificationXref1359
type: UnificationXref
id: 2090075
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2090075

http://identifiers.org/pubmed/2069720
type: PublicationXref
id: 2069720
author: Myöhänen, S
author: Kauppinen, L
author: Jänne, J
author: Wahlfors, J
author: Alhonen, L
db: Pubmed
title: Human spermidine synthase gene: structure and chromosomal localization
source: DNA Cell Biol 10:467-74
year: 1991

UnificationXref331
type: UnificationXref
id: REACT_104340
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104340.9

UnificationXref330
type: UnificationXref
id: 4232080
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232080

UnificationXref3491
type: UnificationXref
id: 4231533
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231533

UnificationXref1352
type: UnificationXref
id: REACT_136725
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136725.5

UnificationXref3490
type: UnificationXref
id: P06960
db: UniProt

UnificationXref1351
type: UnificationXref
id: 4233520
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233520

UnificationXref1354
type: UnificationXref
id: REACT_138877
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138877.5

UnificationXref1353
type: UnificationXref
id: 4233521
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233521

UnificationXref3495
type: UnificationXref
id: REACT_101361
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101361.9

UnificationXref1356
type: UnificationXref
id: 2065212
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2065212

UnificationXref3494
type: UnificationXref
id: 4231537
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231537

UnificationXref2360
type: UnificationXref
id: REACT_154555
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154555.3

UnificationXref1355
type: UnificationXref
id: CHEBI:63505
db: ChEBI

UnificationXref3493
type: UnificationXref
id: 4231535
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231535

UnificationXref2361
type: UnificationXref
id: CHEBI:15628
db: ChEBI

UnificationXref1358
type: UnificationXref
id: CHEBI:63503
db: ChEBI

UnificationXref3492
type: UnificationXref
id: 4231534
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231534

UnificationXref2362
type: UnificationXref
id: 2142718
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142718

UnificationXref1357
type: UnificationXref
id: REACT_125608
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125608.1

UnificationXref3499
type: UnificationXref
id: 34575
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=34575

UnificationXref2363
type: UnificationXref
id: REACT_152325
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152325.1

UnificationXref3498
type: UnificationXref
id: CHEBI:15682
db: ChEBI

UnificationXref2364
type: UnificationXref
id: CHEBI:15558
db: ChEBI

UnificationXref3497
type: UnificationXref
id: REACT_3861
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3861.3

UnificationXref2365
type: UnificationXref
id: 2142707
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142707

http://identifiers.org/pubmed/18597486
type: PublicationXref
id: 18597486
author: Frank, CG
author: Sanyal, S
author: Menon, AK
db: Pubmed
title: Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulum
source: Biochemistry 47:7937-46
year: 2008

UnificationXref3496
type: UnificationXref
id: 29968
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29968

UnificationXref2366
type: UnificationXref
id: REACT_152496
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152496.1

UnificationXref2367
type: UnificationXref
id: 4233214
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233214

UnificationXref2368
type: UnificationXref
id: 4233215
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233215

http://identifiers.org/pubmed/10215861
type: PublicationXref
id: 10215861
author: van den Bosch, H
author: Just, WW
author: Wanders, RJ
author: Biermann, J
db: Pubmed
title: Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes
source: Eur J Biochem 261:492-9
year: 1999

UnificationXref2369
type: UnificationXref
id: 4233217
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233217

UnificationXref1350
type: UnificationXref
id: REACT_137583
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137583.5

mitochondrial fatty acid beta-oxidation of saturated fatty acids
type: Pathway
data source: Provenance1
pathway component: REACT 86279.9
pathway component: Beta oxidation of octanoyl-CoA to hexanoyl-CoA
pathway component: REACT 85567.9
pathway component: REACT 81455.9
pathway component: Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
pathway component: REACT 136475.5
pathway component: REACT 129172.5
evidence: Evidence311
xref: UnificationXref1969
xref: UnificationXref1968
xref: RelationshipXref242
pathway order: PathwayStep283
pathway order: PathwayStep292
pathway order: PathwayStep286
pathway order: PathwayStep289
pathway order: PathwayStep295
pathway order: PathwayStep279
pathway order: PathwayStep297
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref302
type: UnificationXref
id: REACT_94041
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94041.9

UnificationXref301
type: UnificationXref
id: 4232072
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232072

UnificationXref300
type: UnificationXref
id: 4232071
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232071

UnificationXref306
type: UnificationXref
id: REACT_102264
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102264.9

UnificationXref305
type: UnificationXref
id: 4232068
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232068

UnificationXref2339
type: UnificationXref
id: CHEBI:15632
db: ChEBI

UnificationXref304
type: UnificationXref
id: 4232067
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232067

UnificationXref2338
type: UnificationXref
id: REACT_152637
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152637.3

UnificationXref303
type: UnificationXref
id: 4230319
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230319

UnificationXref1328
type: UnificationXref
id: REACT_153728
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153728.3

UnificationXref1329
type: UnificationXref
id: CHEBI:63846
db: ChEBI

UnificationXref1326
type: UnificationXref
id: REACT_155712
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155712.3

UnificationXref1327
type: UnificationXref
id: 4233398
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233398

UnificationXref3460
type: UnificationXref
id: 4233337
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233337

UnificationXref1325
type: UnificationXref
id: 4232179
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232179

UnificationXref1324
type: UnificationXref
id: REACT_7132
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7132.1

UnificationXref3462
type: UnificationXref
id: P76217
db: UniProt

UnificationXref1323
type: UnificationXref
id: 158471
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158471

UnificationXref3461
type: UnificationXref
id: REACT_100913
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100913.9

UnificationXref1322
type: UnificationXref
id: CHEBI:17980
db: ChEBI

UnificationXref1321
type: UnificationXref
id: REACT_157363
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157363.3

UnificationXref1320
type: UnificationXref
id: 4232181
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232181

UnificationXref3468
type: UnificationXref
id: REACT_77859
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77859.9

UnificationXref2336
type: UnificationXref
id: REACT_108503
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108503.9

UnificationXref309
type: UnificationXref
id: CHEBI:17568
db: ChEBI

UnificationXref3467
type: UnificationXref
id: 4233325
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233325

UnificationXref2337
type: UnificationXref
id: 4233434
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233434

UnificationXref2334
type: UnificationXref
id: 4232343
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232343

UnificationXref307
type: UnificationXref
id: 4233375
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233375

UnificationXref3469
type: UnificationXref
id: CHEBI:16946
db: ChEBI

UnificationXref2335
type: UnificationXref
id: 4232345
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232345

UnificationXref308
type: UnificationXref
id: REACT_81261
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81261.9

UnificationXref3464
type: UnificationXref
id: 4231594
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231594

UnificationXref2332
type: UnificationXref
id: 4232341
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232341

UnificationXref3463
type: UnificationXref
id: 4231593
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231593

UnificationXref2333
type: UnificationXref
id: 4232342
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232342

UnificationXref3466
type: UnificationXref
id: REACT_112402
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112402.8

UnificationXref2330
type: UnificationXref
id: 4232339
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232339

UnificationXref3465
type: UnificationXref
id: 4231596
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231596

UnificationXref2331
type: UnificationXref
id: 4232340
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232340

UnificationXref311
type: UnificationXref
id: REACT_4654
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4654.2

http://identifiers.org/pubmed/19762341
type: PublicationXref
id: 19762341
author: Morikawa, M
author: Kamiya, Y
author: Miyazono, K
db: Pubmed
title: Bone morphogenetic protein receptors and signal transduction
source: J Biochem 147:35-51
year: 2010

UnificationXref310
type: UnificationXref
id: 29554
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29554

UnificationXref313
type: UnificationXref
id: 4232074
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232074

UnificationXref312
type: UnificationXref
id: 4232073
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232073

UnificationXref315
type: UnificationXref
id: CHEBI:17821
db: ChEBI

UnificationXref2349
type: UnificationXref
id: 2142733
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142733

UnificationXref314
type: UnificationXref
id: REACT_92976
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92976.9

UnificationXref317
type: UnificationXref
id: REACT_4549
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4549.2

UnificationXref316
type: UnificationXref
id: 29692
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29692

UnificationXref1337
type: UnificationXref
id: 4233145
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233145

UnificationXref1338
type: UnificationXref
id: 4233147
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233147

UnificationXref1339
type: UnificationXref
id: REACT_130182
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130182.5

UnificationXref3473
type: UnificationXref
id: 893617
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=893617

UnificationXref1334
type: UnificationXref
id: CHEBI:63850
db: ChEBI

UnificationXref3472
type: UnificationXref
id: CHEBI:17442
db: ChEBI

UnificationXref1333
type: UnificationXref
id: REACT_116559
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116559.2

UnificationXref3471
type: UnificationXref
id: REACT_27004
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27004.2

UnificationXref1336
type: UnificationXref
id: REACT_122540
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122540.1

UnificationXref3470
type: UnificationXref
id: 893607
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=893607

UnificationXref2340
type: UnificationXref
id: 266010
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266010

UnificationXref1335
type: UnificationXref
id: 2104997
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2104997

UnificationXref1330
type: UnificationXref
id: 2105007
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2105007

UnificationXref1332
type: UnificationXref
id: 1606845
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1606845

UnificationXref1331
type: UnificationXref
id: REACT_125377
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125377.1

UnificationXref2345
type: UnificationXref
id: CHEBI:17858
db: ChEBI

UnificationXref318
type: UnificationXref
id: 4232075
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232075

UnificationXref2346
type: UnificationXref
id: 111745
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111745

UnificationXref319
type: UnificationXref
id: REACT_94831
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94831.9

UnificationXref3479
type: UnificationXref
id: CHEBI:17672
db: ChEBI

UnificationXref2347
type: UnificationXref
id: REACT_3495
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3495.2

UnificationXref3478
type: UnificationXref
id: REACT_141423
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141423.5

UnificationXref2348
type: UnificationXref
id: CHEBI:28209
db: ChEBI

UnificationXref3477
type: UnificationXref
id: 4233488
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233488

UnificationXref2341
type: UnificationXref
id: REACT_15596
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15596.2

UnificationXref3476
type: UnificationXref
id: REACT_144960
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144960.5

UnificationXref2342
type: UnificationXref
id: CHEBI:16856
db: ChEBI

UnificationXref3475
type: UnificationXref
id: 4232786
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232786

UnificationXref2343
type: UnificationXref
id: 29450
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29450

UnificationXref3474
type: UnificationXref
id: REACT_25814
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25814.1

UnificationXref2344
type: UnificationXref
id: REACT_3050
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3050.2

UnificationXref3443
type: UnificationXref
id: CHEBI:15524
db: ChEBI

UnificationXref2397
type: UnificationXref
id: REACT_151064
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151064.1

UnificationXref3444
type: UnificationXref
id: 70955
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70955

UnificationXref2396
type: UnificationXref
id: 2142761
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142761

UnificationXref3441
type: UnificationXref
id: 4232734
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232734

UnificationXref2399
type: UnificationXref
id: REACT_152681
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152681.3

UnificationXref3442
type: UnificationXref
id: REACT_129874
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129874.5

UnificationXref2398
type: UnificationXref
id: 4233213
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233213

UnificationXref3447
type: UnificationXref
id: REACT_80759
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80759.9

UnificationXref3448
type: UnificationXref
id: 4233326
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233326

UnificationXref3445
type: UnificationXref
id: REACT_2558
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2558.2

UnificationXref3446
type: UnificationXref
id: 4231654
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231654

http://identifiers.org/pubmed/1522213
type: PublicationXref
id: 1522213
author: Iwata, H
author: Hanyu, Y
author: Yamagishi, A
author: Ogawa, T
author: Fukuda, S
author: Nakashima, Y
author: Masue, M
author: Hori, T
author: Sukegawa, K
author: Tomatsu, S
db: Pubmed
title: Mucopolysaccharidosis type IVA. N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases
source: J Clin Invest 90:1049-53
year: 1992

UnificationXref2391
type: UnificationXref
id: REACT_155029
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155029.3

D-Erythrose 4-phosphate [ChEBI:16897]
type: SmallMoleculeReference
name: D-Erythrose 4-phosphate
xref: UnificationXref1711

UnificationXref2390
type: UnificationXref
id: 4233542
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233542

UnificationXref2393
type: UnificationXref
id: 2161759
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161759

http://identifiers.org/pubmed/10339581
type: PublicationXref
id: 10339581
author: Zhang, H
author: Natowicz, M R
author: Wicklow, B A
author: Salo, T J
author: Triggs-Raine, B
db: Pubmed
title: Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX
source: Proc. Natl. Acad. Sci. U.S.A. 96:6296-300
year: 1999

Glyoxylate
type: SmallMoleculeReference
name: Glyoxalate
name: Glyoxylic acid
name: Glyoxylate [ChEBI:5509]
xref: UnificationXref3561

UnificationXref3440
type: UnificationXref
id: REACT_108504
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108504.9

UnificationXref2392
type: UnificationXref
id: CHEBI:6498
db: ChEBI

UnificationXref2395
type: UnificationXref
id: CHEBI:63992
db: ChEBI

UnificationXref2394
type: UnificationXref
id: REACT_152342
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152342.1

Synthesis of bile acids and bile salts
type: Pathway
data source: Provenance1
pathway component: REACT 30876.10
evidence: Evidence339
xref: RelationshipXref277
xref: UnificationXref2156
xref: UnificationXref2157
pathway order: PathwayStep325
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3449
type: UnificationXref
id: REACT_113274
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113274.8

UnificationXref3452
type: UnificationXref
id: REACT_2627
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2627.1

2xMUT (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry151
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1999
cellular location: intracellular
comment: Reactome DB_ID: 4231633

UnificationXref3453
type: UnificationXref
id: P0A959
db: UniProt

BDH1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry153
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2014
cellular location: intracellular
comment: Reactome DB_ID: 4231894

UnificationXref3454
type: UnificationXref
id: 4231658
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231658

OXCT1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry154
component: Homologues of OXCT1
xref: UnificationXref2029
cellular location: intracellular
comment: Reactome DB_ID: 4231905

UnificationXref3455
type: UnificationXref
id: 4231659
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231659

HACL1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry158
component: HACL1 holoenzyme monomer (name copied from entity in Homo sapiens)
xref: UnificationXref2072
cellular location: intracellular
comment: Reactome DB_ID: 4232472

UnificationXref3456
type: UnificationXref
id: 4231661
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231661

UnificationXref3457
type: UnificationXref
id: REACT_31573
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31573.10

2xMMAA (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry145
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1988
cellular location: intracellular
comment: Reactome DB_ID: 4231627

UnificationXref3458
type: UnificationXref
id: 4232744
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232744

2xMUT:AdoCbl (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry148
component stoichiometry: Stoichiometry147
component: Note: the coordinates are copied over from Homo sapiens.
component: SmallMolecule326
xref: UnificationXref1994
cellular location: intracellular
comment: Reactome DB_ID: 4231631

UnificationXref3459
type: UnificationXref
id: REACT_143415
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143415.5

2xMMAA:2xMUT (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry152
component stoichiometry: Stoichiometry150
component: 2xMUT (name copied from entity in Homo sapiens)
component: 2xMMAA (name copied from entity in Homo sapiens)
xref: UnificationXref2000
cellular location: intracellular
comment: Reactome DB_ID: 4231634

http://identifiers.org/pubmed/19416660
type: PublicationXref
id: 19416660
author: Ren, M
author: Xu, Y
author: Malhotra, A
author: Schlame, M
db: Pubmed
title: Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species
source: Biochim Biophys Acta 1791:314-20
year: 2009

HACL1 holoenzyme monomer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry157
component stoichiometry: Stoichiometry156
component stoichiometry: Stoichiometry155
component: SmallMolecule339
component: SmallMolecule338
component: P0AFI0
xref: UnificationXref2071
cellular location: intracellular
comment: Reactome DB_ID: 4232471

GNPAT:AGPS complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry162
component stoichiometry: Stoichiometry161
component: AGPS:FAD (name copied from entity in Homo sapiens)
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2115
cellular location: intracellular
comment: Reactome DB_ID: 4231945

UnificationXref3450
type: UnificationXref
id: CHEBI:15999
db: ChEBI

AGPS:FAD (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry159
component stoichiometry: Stoichiometry160
component: Note: the coordinates are copied over from Homo sapiens.
component: SmallMolecule349
xref: UnificationXref2113
cellular location: intracellular
comment: Reactome DB_ID: 4231944

UnificationXref3451
type: UnificationXref
id: 31365
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31365

http://identifiers.org/pubmed/12811560
type: PublicationXref
id: 12811560
author: Edwards, RH
author: Reimer, RJ
db: Pubmed
title: Organic anion transport is the primary function of the SLC17/type I phosphate transporter family
source: Pflugers Arch 447:629-35
year: 2004

http://identifiers.org/pubmed/12811562
type: PublicationXref
id: 12811562
author: Bartoloni, L
author: Antonarakis, SE
db: Pubmed
title: The human sugar-phosphate/phosphate exchanger family SLC37
source: Pflugers Arch 447:780-3
year: 2004

UnificationXref3425
type: UnificationXref
id: 4233320
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233320

UnificationXref2379
type: UnificationXref
id: REACT_152057
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152057.1

IMPA1/2
type: Complex
data source: Provenance1
member physical entity: IMPA2 dimer (name copied from entity in Homo sapiens)
member physical entity: IMPA1 dimer (name copied from entity in Homo sapiens)
xref: UnificationXref1767
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4233175

UnificationXref3426
type: UnificationXref
id: REACT_79609
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79609.9

UnificationXref2378
type: UnificationXref
id: 2142716
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142716

IMPA1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry135
component: IMPA1:Mg2+ (name copied from entity in Homo sapiens)
xref: UnificationXref1763
cellular location: intracellular
comment: Reactome DB_ID: 4233171

UnificationXref3423
type: UnificationXref
id: 4233493
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233493

UnificationXref3424
type: UnificationXref
id: REACT_132577
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132577.5

UnificationXref3421
type: UnificationXref
id: 4232947
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232947

UnificationXref2375
type: UnificationXref
id: 2142790
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142790

IMPA2:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry137
component stoichiometry: Stoichiometry136
component: Note: the coordinates are copied over from Homo sapiens.
component: Mg++
xref: UnificationXref1765
cellular location: intracellular
comment: Reactome DB_ID: 4233173

UnificationXref3422
type: UnificationXref
id: REACT_132940
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132940.5

UnificationXref2374
type: UnificationXref
id: CHEBI:34145
db: ChEBI

phosphorylated HSL dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry140
component: phospho-p-S649,S650-LIPE
xref: UnificationXref1786
cellular location: intracellular
comment: Reactome DB_ID: 4232161

UnificationXref2377
type: UnificationXref
id: CHEBI:34144
db: ChEBI

IMPA1:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry134
component stoichiometry: Stoichiometry133
component: Note: the coordinates are copied over from Homo sapiens.
component: Mg++
xref: UnificationXref1762
cellular location: intracellular
comment: Reactome DB_ID: 4233170

UnificationXref3420
type: UnificationXref
id: 4232945
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232945

UnificationXref2376
type: UnificationXref
id: REACT_151674
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151674.1

IMPA2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry138
component: IMPA2:Mg2+ (name copied from entity in Homo sapiens)
xref: UnificationXref1766
cellular location: intracellular
comment: Reactome DB_ID: 4233174

UnificationXref2371
type: UnificationXref
id: REACT_158200
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158200.3

DECR1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry144
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1978
cellular location: intracellular
comment: Reactome DB_ID: 4232011

UnificationXref2370
type: UnificationXref
id: 4233219
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233219

2xMMAA:2xMUT:AdoCbl (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry149
component stoichiometry: Stoichiometry146
component: 2xMUT:AdoCbl (name copied from entity in Homo sapiens)
component: 2xMMAA (name copied from entity in Homo sapiens)
xref: UnificationXref1995
cellular location: intracellular
comment: Reactome DB_ID: 4231632

UnificationXref2373
type: UnificationXref
id: REACT_156659
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156659.3

Trifunctional Protein (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry142
component stoichiometry: Stoichiometry141
component: P76503
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1846
cellular location: intracellular
comment: Reactome DB_ID: 4231983

UnificationXref2372
type: UnificationXref
id: 4233540
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233540

ECHS1 hexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry143
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1891
cellular location: intracellular
comment: Reactome DB_ID: 4231974

http://identifiers.org/pubmed/18511455
type: PublicationXref
id: 18511455
author: Giacomini, KM
author: Hurowitz, E
author: Zador, Z
author: Sorani, MD
author: Manley, GT
author: Yan, D
db: Pubmed
title: Novel variants in human Aquaporin-4 reduce cellular water permeability
source: Hum Mol Genet 17:2379-89
year: 2008

http://identifiers.org/pubmed/15381398
type: PublicationXref
id: 15381398
author: Jaffe, EK
db: Pubmed
title: The porphobilinogen synthase catalyzed reaction mechanism
source: Bioorg Chem 32:316-25
year: 2004

UnificationXref3429
type: UnificationXref
id: REACT_21673
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21673.2

UnificationXref3428
type: UnificationXref
id: 508531
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=508531

UnificationXref3427
type: UnificationXref
id: CHEBI:17082
db: ChEBI

UnificationXref3434
type: UnificationXref
id: 4231600
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231600

UnificationXref3435
type: UnificationXref
id: P77730
db: UniProt

UnificationXref3436
type: UnificationXref
id: 4231604
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231604

UnificationXref3437
type: UnificationXref
id: 4231605
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231605

UnificationXref2389
type: UnificationXref
id: REACT_158130
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158130.3

PGYM dimer, b form (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry120
component: Homologues of PXLP-PYGM
xref: UnificationXref1638
cellular location: intracellular
comment: Reactome DB_ID: 4231713

UnificationXref3430
type: UnificationXref
id: CHEBI:15753
db: ChEBI

UnificationXref2388
type: UnificationXref
id: 4233226
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233226

PGYM b dimer:AMP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry121
component stoichiometry: Stoichiometry122
component: SmallMolecule137
component: Homologues of PXLP-PYGM
xref: UnificationXref1639
cellular location: intracellular
comment: Reactome DB_ID: 4232692

UnificationXref3431
type: UnificationXref
id: 70951
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70951

UnificationXref2387
type: UnificationXref
id: REACT_150517
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150517.1

GALE dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry125
component stoichiometry: Stoichiometry124
component: Note: the coordinates are copied over from Homo sapiens.
component: DPN
xref: UnificationXref1670
cellular location: intracellular
comment: Reactome DB_ID: 4231466

UnificationXref3432
type: UnificationXref
id: REACT_2814
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2814.1

UnificationXref2386
type: UnificationXref
id: 2142678
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142678

G6PD dimer and tetramer
type: Complex
data source: Provenance1
member physical entity: G6PD dimer (name copied from entity in Homo sapiens)
member physical entity: G6PD tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref1682
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231474

UnificationXref3433
type: UnificationXref
id: P39389
db: UniProt

UnificationXref2385
type: UnificationXref
id: CHEBI:34146
db: ChEBI

G6PD dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry126
component stoichiometry: Stoichiometry127
component: NADP+
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1680
cellular location: intracellular
comment: Reactome DB_ID: 4231472

UnificationXref2384
type: UnificationXref
id: REACT_151618
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151618.1

G6PD tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry129
component stoichiometry: Stoichiometry128
component: NADP+
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1681
cellular location: intracellular
comment: Reactome DB_ID: 4231473

UnificationXref2383
type: UnificationXref
id: 2142811
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142811

PGD dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry130
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1695
cellular location: intracellular
comment: Reactome DB_ID: 4231671

UnificationXref2382
type: UnificationXref
id: CHEBI:15626
db: ChEBI

RPE dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry131
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1703
cellular location: intracellular
comment: Reactome DB_ID: 4231677

UnificationXref2381
type: UnificationXref
id: REACT_155887
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155887.3

phosphoribosyl pyrophosphate synthetase 1 holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry132
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1745
cellular location: intracellular
comment: Reactome DB_ID: 4231786

UnificationXref2380
type: UnificationXref
id: 4233225
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233225

phosphoribosyl pyrophosphate synthetase holoenzyme
type: Complex
data source: Provenance1
member physical entity: phosphoribosyl pyrophosphate synthetase 1 holoenzyme (name copied from entity in Homo sapiens)
xref: UnificationXref1750
cellular location: intracellular
comment: Reactome DB_ID: 4231787
comment: Converted from EntitySet in Reactome

http://identifiers.org/pubmed/7535000
type: PublicationXref
id: 7535000
author: Carone, FA
author: Perrone, RD
author: Brown, D
author: Jefferson, DM
author: Bachinsky, DR
author: Emmanouel, DS
author: Sabolic, I
db: Pubmed
title: Water channel expression in human ADPKD kidneys
source: Am J Physiol 268:F398
year: 1995

http://identifiers.org/pubmed/9521684
type: PublicationXref
id: 9521684
author: von Figura, K
author: Selmer, T
author: Saenger, W
author: Gieselmann, V
author: Theis, K
author: Krauss, N
author: Lukatela, G
db: Pubmed
title: Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis
source: Biochemistry 37:3654-64
year: 1998

UnificationXref3439
type: UnificationXref
id: 4231608
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231608

http://identifiers.org/pubmed/15607332
type: PublicationXref
id: 15607332
author: Takemura, Y
author: Tazawa, S
author: Isogai, T
author: Wakamatsu, A
author: Fujikura, H
author: Sugiyama, T
author: Tomae, M
author: Yamato, T
author: Isaji, M
author: Itoh, F
author: Maruyama, H
author: Hiratochi, M
db: Pubmed
title: SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose
source: Life Sci 76:1039-50
year: 2005

UnificationXref3438
type: UnificationXref
id: 4231606
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231606

http://identifiers.org/pubmed/1639787
type: PublicationXref
id: 1639787
author: Duncan, TM
author: Tempst, P
author: Fleischer, S
author: McIntyre, JO
author: Erdjument-Bromage, H
author: Marks, AR
db: Pubmed
title: Molecular cloning and characterization of (R)-3-hydroxybutyrate dehydrogenase from human heart
source: J Biol Chem 267:15459-63
year: 1992

PGYB b dimer:AMP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry117
component stoichiometry: Stoichiometry116
component: Homologues of PXLP-PYGB
component: SmallMolecule137
xref: UnificationXref1630
cellular location: intracellular
comment: Reactome DB_ID: 4232697

PGYB dimer b form (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry115
component: Homologues of PXLP-PYGB
xref: UnificationXref1629
cellular location: intracellular
comment: Reactome DB_ID: 4232685

PGM1:Mg++ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry112
component stoichiometry: Stoichiometry113
component: P36938
component: Mg++
xref: UnificationXref1619
cellular location: intracellular
comment: Reactome DB_ID: 4231450

GOT1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry110
component stoichiometry: Stoichiometry111
component: Homologues of GOT1
component: SmallMolecule207
xref: UnificationXref1599
cellular location: intracellular
comment: Reactome DB_ID: 4231557

GOT2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry109
component: Homologues of PXLP-GOT2
xref: UnificationXref1589
cellular location: intracellular
comment: Reactome DB_ID: 4231566

malate dehydrogenase 2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry108
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1580
cellular location: intracellular
comment: Reactome DB_ID: 4231612

(S)-Hydroxydecanoyl-CoA
type: SmallMoleculeReference
name: (S)-3-Hydroxydecanoyl-CoA
name: (S)-Hydroxydecanoyl-CoA [ChEBI:28325]
xref: UnificationXref1907

UnificationXref3400
type: UnificationXref
id: 4231574
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231574

pyruvate carboxylase holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry105
component stoichiometry: Stoichiometry107
component stoichiometry: Stoichiometry106
component: Mn(III)
component: Note: the coordinates are copied over from Homo sapiens.
component: Coenzyme R
xref: UnificationXref1567
cellular location: intracellular
comment: Reactome DB_ID: 4231524

pyruvate kinase complex, liver and RBC (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry102
component stoichiometry: Stoichiometry103
component stoichiometry: Stoichiometry104
component: SmallMolecule7
component: Protein48
component: Mg++
xref: UnificationXref1529
cellular location: intracellular
comment: Reactome DB_ID: 4231737

pyruvate kinase M1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry100
component stoichiometry: Stoichiometry99
component stoichiometry: Stoichiometry101
component: SmallMolecule7
component: Mg++
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1528
cellular location: intracellular
comment: Reactome DB_ID: 4231735

pyruvate kinase tetramer
type: Complex
data source: Provenance1
member physical entity: pyruvate kinase complex, liver and RBC (name copied from entity in Homo sapiens)
member physical entity: pyruvate kinase M1 complex (name copied from entity in Homo sapiens)
xref: UnificationXref1530
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231738

UnificationXref3404
type: UnificationXref
id: REACT_117597
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117597.1

UnificationXref3403
type: UnificationXref
id: 977329
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=977329

UnificationXref3402
type: UnificationXref
id: CHEBI:30933
db: ChEBI

UnificationXref3401
type: UnificationXref
id: REACT_107530
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107530.9

UnificationXref3407
type: UnificationXref
id: 4232957
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232957

UnificationXref3408
type: UnificationXref
id: 4232959
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232959

UnificationXref3405
type: UnificationXref
id: P0A9T0
db: UniProt

UnificationXref3406
type: UnificationXref
id: 4232956
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232956

UnificationXref3409
type: UnificationXref
id: REACT_133723
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133723.5

Synthesis of lysophosphatidic acid from dihydroxyacetone phosphate
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction176
pathway component: BiochemicalReaction177
evidence: Evidence333
xref: RelationshipXref271
xref: UnificationXref2129
xref: UnificationXref2130
pathway order: PathwayStep318
pathway order: PathwayStep319
display name: Plasmalogen biosynthesis
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

phosphoglycerate mutase 2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry96
component: P62707
xref: UnificationXref1512
cellular location: intracellular
comment: Reactome DB_ID: 4231700

Lysine catabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction306
pathway component: BiochemicalReaction305
pathway component: BiochemicalReaction304
evidence: Evidence522
xref: UnificationXref3448
xref: RelationshipXref505
xref: UnificationXref3449
pathway order: PathwayStep508
pathway order: PathwayStep507
pathway order: PathwayStep509
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

phosphoglycerate mutase 1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry95
component: P62707
xref: UnificationXref1510
cellular location: intracellular
comment: Reactome DB_ID: 4231698

enolase 1 dimer, (alpha) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry98
component stoichiometry: Stoichiometry97
component: Note: the coordinates are copied over from Homo sapiens.
component: Mg++
xref: UnificationXref1521
cellular location: intracellular
comment: Reactome DB_ID: 4231518

triosephosphate isomerase dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry92
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1488
cellular location: intracellular
comment: Reactome DB_ID: 4231481

phosphofructokinase, PL3 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry91
component stoichiometry: Stoichiometry90
component: PFK-B
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1465
cellular location: intracellular
comment: Reactome DB_ID: 4231492

phosphoglycerate mutase dimer
type: Complex
data source: Provenance1
member physical entity: phosphoglycerate mutase 2 dimer (name copied from entity in Homo sapiens)
member physical entity: phosphoglycerate mutase 1 dimer (name copied from entity in Homo sapiens)
xref: UnificationXref1513
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231701

http://identifiers.org/pubmed/20435355
type: PublicationXref
id: 20435355
author: Palczewski, Krzysztof
db: Pubmed
title: Retinoids for treatment of retinal diseases
source: Trends Pharmacol. Sci. 31:284-95
year: 2010

http://identifiers.org/pubmed/17251001
type: PublicationXref
id: 17251001
author: Kodali, R
author: Wetzel, R
db: Pubmed
title: Polymorphism in the intermediates and products of amyloid assembly
source: Curr Opin Struct Biol 17:48-57
year: 2007

phosphoglycerate kinase 1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry94
component stoichiometry: Stoichiometry93
component: PRP 2
component: Mg++
xref: UnificationXref1502
cellular location: intracellular
comment: Reactome DB_ID: 4231512

phosphofructokinase, P4 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry85
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1462
cellular location: intracellular
comment: Reactome DB_ID: 4231489

UnificationXref3411
type: UnificationXref
id: 936706
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936706

phosphofructokinase, P2L2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry88
component stoichiometry: Stoichiometry89
component: PFK-B
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1464
cellular location: intracellular
comment: Reactome DB_ID: 4231491

UnificationXref3410
type: UnificationXref
id: CHEBI:15811
db: ChEBI

phosphofructokinase, P3L complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry86
component stoichiometry: Stoichiometry87
component: PFK-B
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1463
cellular location: intracellular
comment: Reactome DB_ID: 4231490

UnificationXref3413
type: UnificationXref
id: P23721
db: UniProt

UniProt:P0AFG6
type: ProteinReference
xref: UnificationXref2563
organism: BioSource1

UnificationXref3412
type: UnificationXref
id: REACT_27529
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27529.1

UniProt:P0AFG3
type: ProteinReference
xref: UnificationXref2570
organism: BioSource1

UnificationXref3415
type: UnificationXref
id: 4232951
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232951

UnificationXref3414
type: UnificationXref
id: 4232950
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232950

UnificationXref3416
type: UnificationXref
id: 4232953
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232953

UnificationXref3417
type: UnificationXref
id: REACT_137150
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137150.5

UnificationXref3418
type: UnificationXref
id: P0AGB0
db: UniProt

UnificationXref3419
type: UnificationXref
id: 4232944
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232944

Lipid digestion, mobilization, and transport
type: Pathway
data source: Provenance1
pathway component: Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
evidence: Evidence284
xref: UnificationXref1796
xref: UnificationXref1797
pathway order: PathwayStep270
display name: Lipid and lipoprotein metabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

GUSB tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry79
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1295
cellular location: intracellular
comment: Reactome DB_ID: 4233155

HSP90:Benzoquinoid ansamycins (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry78
component stoichiometry: Stoichiometry77
component: SmallMolecule214
component: HSP90 (name copied from entity in Homo sapiens)
xref: UnificationXref1269
cellular location: intracellular
comment: Reactome DB_ID: 4232972

HSP90 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry75
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1251
cellular location: intracellular
comment: Reactome DB_ID: 4232971

Homodimer of 4 aminobutyrate aminotransferase (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry74
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1194
cellular location: intracellular
comment: Reactome DB_ID: 4232850

phosphofructokinase, L4 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry84
component: PFK-B
xref: UnificationXref1460
cellular location: intracellular
comment: Reactome DB_ID: 4231487

UniProt:P62707
type: ProteinReference
xref: UnificationXref1508
organism: BioSource1

phosphofructokinase tetramer
type: Complex
data source: Provenance1
member physical entity: phosphofructokinase, P4 complex (name copied from entity in Homo sapiens)
member physical entity: phosphofructokinase, P3L complex (name copied from entity in Homo sapiens)
member physical entity: phosphofructokinase, L4 complex (name copied from entity in Homo sapiens)
member physical entity: phosphofructokinase, PL3 complex (name copied from entity in Homo sapiens)
member physical entity: phosphofructokinase, P2L2 complex (name copied from entity in Homo sapiens)
xref: UnificationXref1466
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231493

glucose 6-phosphate isomerase dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry83
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1452
cellular location: intracellular
comment: Reactome DB_ID: 4231504

ARSB:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry81
component stoichiometry: Stoichiometry80
component: SmallMolecule237
component: Homologues of OxA-ARSB
xref: UnificationXref1384
cellular location: intracellular
comment: Reactome DB_ID: 4233028

UniProt:P0AFF2
type: ProteinReference
xref: UnificationXref587
organism: BioSource1

GLS2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry73
component: Homologues of GLS2
xref: UnificationXref1171
cellular location: intracellular
comment: Reactome DB_ID: 4231586

GLS dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry72
component: Homologues of GLS
xref: UnificationXref1167
cellular location: intracellular
comment: Reactome DB_ID: 4231582

http://identifiers.org/pubmed/16302959
type: PublicationXref
id: 16302959
author: Westermark, P
db: Pubmed
title: Aspects on human amyloid forms and their fibril polypeptides
source: FEBS J 272:5942-9
year: 2005

UnificationXref388
type: UnificationXref
id: 4232513
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232513

UnificationXref387
type: UnificationXref
id: 4232512
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232512

UnificationXref389
type: UnificationXref
id: 4232515
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232515

http://identifiers.org/pubmed/18456538
type: PublicationXref
id: 18456538
author: Bret, J
author: Lemaire, O
author: Prat, C
author: Fournié, B
author: Zabraniecki, L
db: Pubmed
title: Morquio syndrome: diagnosis in an adult
source: Joint Bone Spine 75:495-8
year: 2008

UnificationXref380
type: UnificationXref
id: 4233444
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233444

UnificationXref382
type: UnificationXref
id: P32703
db: UniProt

GLS dimers
type: Complex
data source: Provenance1
member physical entity: GLS dimer (name copied from entity in Homo sapiens)
member physical entity: GLS2 dimer (name copied from entity in Homo sapiens)
xref: UnificationXref1172
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231587

UnificationXref381
type: UnificationXref
id: REACT_114763
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114763.8

UnificationXref384
type: UnificationXref
id: 4232509
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232509

UnificationXref383
type: UnificationXref
id: 4232508
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232508

UnificationXref386
type: UnificationXref
id: 4232511
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232511

UnificationXref385
type: UnificationXref
id: 4232510
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232510

DARS2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry58
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref859
cellular location: intracellular
comment: Reactome DB_ID: 4232429

YARS dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry57
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref824
cellular location: intracellular
comment: Reactome DB_ID: 4232382

YARS2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry60
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref972
cellular location: intracellular
comment: Reactome DB_ID: 4232388

SARS2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry59
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref948
cellular location: intracellular
comment: Reactome DB_ID: 4232435

Biological oxidations
type: Pathway
data source: Provenance1
pathway component: Phase 1 - Functionalization of compounds
pathway component: Phase II conjugation
evidence: Evidence580
xref: UnificationXref3859
xref: UnificationXref3858
xref: RelationshipXref568
pathway order: PathwayStep566
pathway order: PathwayStep554
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/9435697
type: PublicationXref
id: 9435697
author: Giacomini, KM
author: Wang, J
author: Schaner, ME
author: Su, SF
author: Washington, CB
author: Dresser, MJ
db: Pubmed
title: Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization
source: Am J Physiol Renal Physiol 273:1058-1065
year: 1997

Elongation complex with growing peptide chain
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry66
component stoichiometry: Stoichiometry67
component stoichiometry: Stoichiometry65
component: PhysicalEntity17
component: SmallMolecule196
component: PhysicalEntity18
xref: UnificationXref1040
xref: UnificationXref1039
cellular location: GO:0005829
comment: Reactome DB_ID: 159880

70S:Met-tRNAi:mRNA:aa-tRNA
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry61
component stoichiometry: Stoichiometry63
component stoichiometry: Stoichiometry64
component stoichiometry: Stoichiometry62
component: SmallMolecule176
component: PhysicalEntity16
component: PhysicalEntity17
component: SmallMolecule196
xref: UnificationXref1035
xref: UnificationXref1036
cellular location: GO:0005829
comment: Reactome DB_ID: 159889

HSD17B1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry71
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1150
cellular location: intracellular
comment: Reactome DB_ID: 4232758

70S:mRNA:peptidyl-tRNA with elongating peptide
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry68
component stoichiometry: Stoichiometry69
component stoichiometry: Stoichiometry70
component: PhysicalEntity17
component: SmallMolecule196
component: PhysicalEntity18
xref: UnificationXref1044
xref: UnificationXref1043
cellular location: GO:0005829
comment: Reactome DB_ID: 159891

Aquaporin-9, Aquaporin-10
type: Complex
data source: Provenance1
member physical entity: AQP10 tetramer (name copied from entity in Homo sapiens)
member physical entity: AQP9 tetramer (name copied from entity in Homo sapiens)
name: Aquaporins that transport urea
name: AQP9, AQP10
xref: UnificationXref710
cellular location: plasma membrane
display name: AQP9/10
comment: Reactome DB_ID: 4232721
comment: Converted from EntitySet in Reactome

Catalysis304
type: Catalysis
data source: Provenance1
controlled: Glutathione is hydrolyzed
control type: ACTIVATION
xref: RelationshipXref576
xref: RelationshipXref307
controller: Complex204

Catalysis305
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Carbon Dioxide into the Cell by AQP1
control type: ACTIVATION
xref: RelationshipXref579
xref: RelationshipXref580
controller: AQP1 tetramer (name copied from entity in Homo sapiens)

Catalysis306
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Carbon Dioxide out of the Cell by AQP1
control type: ACTIVATION
xref: RelationshipXref579
xref: RelationshipXref580
controller: AQP1 tetramer (name copied from entity in Homo sapiens)

UnificationXref399
type: UnificationXref
id: GO:0005796
db: GENE ONTOLOGY

Catalysis307
type: Catalysis
data source: Provenance1
controlled: abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine
control type: ACTIVATION
xref: RelationshipXref386
xref: RelationshipXref384
controller: Complex135

UnificationXref398
type: UnificationXref
id: REACT_93564
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93564.9

Catalysis308
type: Catalysis
data source: Provenance1
controlled: carbovir monophosphate + ATP => carbovir diphosphate + ADP
control type: ACTIVATION
xref: RelationshipXref583
xref: RelationshipXref582
controller: Note: the coordinates are copied over from Homo sapiens.

http://identifiers.org/pubmed/20807551
type: PublicationXref
id: 20807551
author: Noël, Jacques
author: Diochot, Sylvie
author: Baron, Anne
author: Deval, Emmanuel
author: Gasull, Xavier
author: Salinas, Miguel
author: Lingueglia, Eric
db: Pubmed
title: Acid-sensing ion channels (ASICs): pharmacology and implication in pain
source: Pharmacol. Ther. 128:549-58
year: 2010

AQP6 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry56
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref691
cellular location: intracellular
comment: Reactome DB_ID: 4232629

UnificationXref393
type: UnificationXref
id: REACT_19509
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19509.1

AQP3, AQP7, AQP9, AQP10
type: Complex
data source: Provenance1
member physical entity: AQP10 tetramer (name copied from entity in Homo sapiens)
member physical entity: AQP9 tetramer (name copied from entity in Homo sapiens)
member physical entity: AQP7 tetramer (name copied from entity in Homo sapiens)
member physical entity: AQP3 tetramer (name copied from entity in Homo sapiens)
name: Aqauporins that transport glycerol across the plasma membrane.
name: Aquaporin-3, Aquaporin-7, Aquaporin-9, Aquaporin-10
xref: UnificationXref700
cellular location: plasma membrane
display name: AQP3/7/9/10
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232716

UnificationXref392
type: UnificationXref
id: 425978
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425978

http://identifiers.org/pubmed/14091597
type: PublicationXref
id: 14091597
author: Lamy, M
author: MARIE, J
author: MAROTEAUX, P
author: Leveque, B
db: Pubmed
title: [A NEW DYSOSTOSIS WITH URINARY ELIMINATION OF CHONDROITIN SULFATE B]
source: Presse Med 71:1849-52
year: 1963

UnificationXref391
type: UnificationXref
id: GO:0031905
db: GENE ONTOLOGY

UnificationXref390
type: UnificationXref
id: REACT_92179
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92179.9

Catalysis300
type: Catalysis
data source: Provenance1
controlled: acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]
control type: ACTIVATION
xref: RelationshipXref566
xref: RelationshipXref564
controller: P27550

UnificationXref397
type: UnificationXref
id: 4232507
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232507

Catalysis301
type: Catalysis
data source: Provenance1
controlled: UDP-glucose is oxidised to UDP-glucuronate
control type: ACTIVATION
xref: RelationshipXref570
xref: RelationshipXref569
controller: Complex202

UnificationXref396
type: UnificationXref
id: 4232505
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232505

Catalysis302
type: Catalysis
data source: Provenance1
controlled: NAT1 acetylation
control type: ACTIVATION
xref: RelationshipXref575
xref: RelationshipXref574
controller: Note: the coordinates are copied over from Homo sapiens.

UnificationXref395
type: UnificationXref
id: REACT_20087
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20087.2

Catalysis303
type: Catalysis
data source: Provenance1
controlled: NAT2 acetylation
control type: ACTIVATION
xref: RelationshipXref575
xref: RelationshipXref574
controller: Note: the coordinates are copied over from Homo sapiens.

UnificationXref394
type: UnificationXref
id: 425971
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425971

Catalysis288
type: Catalysis
data source: Provenance1
controlled: Homocysteine is degraded to oxobutanoate and H2S
control type: ACTIVATION
xref: RelationshipXref541
xref: RelationshipXref542
controller: Complex195

Catalysis287
type: Catalysis
data source: Provenance1
controlled: Cleavage of cystathionine into cysteine
control type: ACTIVATION
xref: RelationshipXref538
xref: RelationshipXref539
controller: Complex195

Catalysis286
type: Catalysis
data source: Provenance1
controlled: Conversion of glyoxylate to oxalate
control type: ACTIVATION
xref: RelationshipXref535
xref: RelationshipXref536
controller: Complex193

Catalysis285
type: Catalysis
data source: Provenance1
controlled: glycolate + O2 => glyoxylate + H2O2
control type: ACTIVATION
xref: RelationshipXref534
xref: RelationshipXref533
controller: Complex193

http://identifiers.org/pubmed/1415574
type: PublicationXref
id: 1415574
author: Wright, EM
author: Kanai, Y
author: Hediger, MA
author: Turk, E
author: Pajor, AM
author: Wells, RG
db: Pubmed
title: Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter
source: Am J Physiol 263:F459-65
year: 1992

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
type: Protein
entity reference: P08178
data source: Provenance1
name: GAR transformylase
name: Trifunctional purine biosynthetic protein adenosine-3 (Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase))
name: Trifunctional purine biosynthetic protein adenosine-3
name: GARS
name: AIRS
name: 5'-phosphoribosylglycinamide transformylase
name: Phosphoribosylamine--glycine ligase
name: Glycinamide ribonucleotide synthetase
name: Note: the coordinates are copied over from Homo sapiens.
name: AIR synthase
name: Phosphoribosylformylglycinamidine cyclo-ligase
name: Phosphoribosylglycinamide formyltransferase
name: P08178
name: Phosphoribosyl-aminoimidazole synthetase
name: GART(2-1010)
name: Phosphoribosylglycinamide synthetase
xref: UnificationXref2678
feature: FragmentFeature246
cellular location: intracellular
comment: Reactome DB_ID: 4231864
display name: GART

Catalysis289
type: Catalysis
data source: Provenance1
controlled: Cysteine is degraded to serine and H2S
control type: ACTIVATION
xref: RelationshipXref544
xref: RelationshipXref543
controller: Complex195

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AG16
data source: Provenance1
name: GPAT
name: Glutamine phosphoribosylpyrophosphate amidotransferase
name: P0AG16
name: Amidophosphoribosyltransferase precursor (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (GPAT)
name: ATASE
name: Amidophosphoribosyltransferase precursor
name: phosphoribosyl pyrophosphate amidotransferase
name: glutamine phosphoribosylpyrophosphate amidotransferase
name: amidophosphoribosyltransferase
xref: UnificationXref2641
feature: FragmentFeature245
cellular location: intracellular
comment: Reactome DB_ID: 4231878
display name: PPAT

http://identifiers.org/pubmed/518841
type: PublicationXref
id: 518841
author: O'Brien, WE
db: Pubmed
title: Isolation and characterization of argininosuccinate synthetase from human liver.
source: Biochemistry 18:5353-6
year: 1980

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A7D7
data source: Provenance1
name: AIR carboxylase
name: Phosphoribosylaminoimidazole carboxylase
name: Phosphoribosylaminoimidazole- succinocarboxamide synthase
name: P0A7D7
name: SAICAR synthetase
name: phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthase
name: PAICS
name: Multifunctional protein ADE2
xref: UnificationXref2708
feature: FragmentFeature248
cellular location: intracellular
comment: Reactome DB_ID: 4231856
display name: AIRC

FGAM synthase
type: Protein
entity reference: P15254
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: FGAMS
name: Formylglycinamide ribotide synthetase
name: Phosphoribosylformylglycinamidine synthase
name: P15254
name: Formylglycinamide ribotide amidotransferase
name: FGARAT
xref: UnificationXref2696
feature: FragmentFeature247
cellular location: intracellular
comment: Reactome DB_ID: 4231869
display name: PFAS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0ADG7
data source: Provenance1
name: IMP (inosine monophosphate) dehydrogenase 1
name: Inosine-5'-monophosphate dehydrogenase 1 (EC 1.1.1.205) (IMP dehydrogenase 1) (IMPDH-I) (IMPD 1)
name: P0ADG7
name: IMP dehydrogenase 1
name: IMPDH-I
name: Inosine-5'-monophosphate dehydrogenase 1
name: IMPD 1
xref: UnificationXref2734
feature: FragmentFeature250
cellular location: intracellular
comment: Reactome DB_ID: 4231841
display name: IMPDH1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P15639
data source: Provenance1
name: Inosinicase
name: Bifunctional purine biosynthesis protein PURH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP synthetase) (ATIC))
name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
name: IMP cyclohydrolase
name: Bifunctional purine biosynthesis protein PURH
name: P15639
name: IMP synthetase
name: AICAR transformylase
name: Phosphoribosylaminoimidazolecarboxamide formyltransferase
xref: UnificationXref2724
feature: FragmentFeature249
cellular location: intracellular
comment: Reactome DB_ID: 4231848
display name: ATIC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A7D4
data source: Provenance1
name: IMP--aspartate ligase 1
name: AMPSase 1
name: P0A7D4
name: Adenylosuccinate synthetase isozyme 1
name: AdSS 1
name: adenylosuccinate synthetase 1
name: adenylosuccinate synthetase like 1
xref: UnificationXref2749
feature: FragmentFeature252
cellular location: intracellular
comment: Reactome DB_ID: 4232097
display name: ADSSL1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P04079
data source: Provenance1
name: guanine monophosphate synthetase
name: Glutamine amidotransferase
name: GMP synthetase
name: P04079
name: GMP synthase (glutamine-hydrolyzing)
xref: UnificationXref2740
feature: FragmentFeature251
cellular location: intracellular
comment: Reactome DB_ID: 4231836
display name: GMPS

Glycosaminoglycan metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 153728.3
pathway component: REACT 134319.5
pathway component: Chondroitin sulfate/dermatan sulfate metabolism
pathway component: REACT 136138.5
pathway component: REACT 138877.5
evidence: Evidence214
xref: UnificationXref1405
xref: RelationshipXref162
xref: UnificationXref1404
pathway order: PathwayStep187
pathway order: PathwayStep201
pathway order: PathwayStep190
pathway order: PathwayStep194
pathway order: PathwayStep197
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P22333
data source: Provenance1
name: Adenosine aminohydrolase
name: P22333
name: Adenosine deaminase
xref: UnificationXref2775
feature: FragmentFeature254
cellular location: intracellular
comment: Reactome DB_ID: 4231922
display name: ADA

IMP--aspartate ligase 2
type: Protein
entity reference: P0A7D4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P0A7D4
name: Adenylosuccinate synthetase (EC 6.3.4.4) (IMP--aspartate ligase) (AdSS) (AMPSase)
name: ADSS(2-456)
name: AMPSase 2
name: Adenylosuccinate synthetase 2
name: adenylosuccinate synthetase
xref: UnificationXref2752
feature: FragmentFeature253
cellular location: intracellular
comment: Reactome DB_ID: 4232100
display name: AdSS 2

UniProt:P15639
type: ProteinReference
xref: UnificationXref2723
organism: BioSource1

Catalysis290
type: Catalysis
data source: Provenance1
controlled: Excess homocysteine yields homolanthionine and H2S
control type: ACTIVATION
xref: RelationshipXref545
xref: RelationshipXref546
controller: Complex195

Catalysis291
type: Catalysis
data source: Provenance1
controlled: Excess cysteine yields lanthionine and H2S
control type: ACTIVATION
xref: RelationshipXref544
xref: RelationshipXref543
controller: Complex195

Catalysis294
type: Catalysis
data source: Provenance1
controlled: Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III
control type: ACTIVATION
xref: RelationshipXref554
xref: RelationshipXref555
controller: Complex199

Catalysis295
type: Catalysis
data source: Provenance1
controlled: Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I
control type: ACTIVATION
xref: RelationshipXref554
xref: RelationshipXref555
controller: Complex199

Catalysis292
type: Catalysis
data source: Provenance1
controlled: Two molecules of ALA condense to form porphobilinogen (PBG)
control type: ACTIVATION
xref: RelationshipXref551
xref: RelationshipXref550
controller: Complex196

Catalysis293
type: Catalysis
data source: Provenance1
controlled: Four PBGs combine through deamination to form hydroxymethylbilane (HMB)
control type: ACTIVATION
xref: RelationshipXref553
xref: RelationshipXref552
controller: Complex198

Catalysis297
type: Catalysis
data source: Provenance1
controlled: Ferrous iron is inserted into protoporphyrin IX to form heme
control type: ACTIVATION
xref: RelationshipXref558
xref: RelationshipXref559
controller: Complex201

Catalysis296
type: Catalysis
data source: Provenance1
controlled: Conversion of coproporphyrinogen III to protoporphyrinogen IX
control type: ACTIVATION
xref: RelationshipXref557
xref: RelationshipXref556
controller: Complex200

Catalysis299
type: Catalysis
data source: Provenance1
controlled: acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]
control type: ACTIVATION
xref: RelationshipXref565
xref: RelationshipXref564
controller: P27550

Catalysis298
type: Catalysis
data source: Provenance1
controlled: COX10 transforms heme to heme O
control type: ACTIVATION
xref: RelationshipXref561
xref: RelationshipXref560
controller: P0AEA5

6-Phospho-D-glucono-1,5-lactone
type: SmallMoleculeReference
name: D-Glucono-1,5-lactone 6-phosphate [ChEBI:16938]
name: D-Glucono-1,5-lactone 6-phosphate
xref: UnificationXref1675

Adenine phosphoribosyltransferase
type: Protein
entity reference: P69503
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P69503
xref: UnificationXref2818
feature: FragmentFeature256
cellular location: intracellular
comment: Reactome DB_ID: 4231910
display name: APRT

P45563
type: Protein
entity reference: UniProt:P45563
data source: Provenance1
xref: UnificationXref2805
cellular location: intracellular
comment: Reactome DB_ID: 4231927

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P22333
data source: Provenance1
name: P22333
name: Adenosine deaminase-like protein
xref: UnificationXref2784
feature: FragmentFeature255
cellular location: intracellular
comment: Reactome DB_ID: 4233195
display name: ADAL

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P07024
data source: Provenance1
name: 5'-NT
name: P07024
name: 5'-nucleotidase, ecto (CD73)
name: 5'-nucleotidase precursor
name: CD73 antigen
name: Ecto-5'-nucleotidase
xref: UnificationXref2858
feature: FragmentFeature260
cellular location: plasma membrane
comment: Reactome DB_ID: 4232003
display name: NT5E

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P60560
data source: Provenance1
name: GMP reductase 2
name: P60560
xref: UnificationXref2836
feature: FragmentFeature259
cellular location: intracellular
comment: Reactome DB_ID: 4232739
display name: GMPR2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P60560
data source: Provenance1
name: GMP reductase 1
name: P60560
xref: UnificationXref2834
feature: FragmentFeature258
cellular location: intracellular
comment: Reactome DB_ID: 4232737
display name: GMPR

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0A9M2
data source: Provenance1
name: HGPRTase
name: Hypoxanthine-guanine phosphoribosyltransferase
name: P0A9M2
name: HGPRT
xref: UnificationXref2827
feature: FragmentFeature257
cellular location: intracellular
comment: Reactome DB_ID: 4231916
display name: HPRT1

Dihydroorotate oxidase
type: Protein
entity reference: P0A7E1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Dihydroorotate dehydrogenase, mitochondrial precursor
name: DHOdehase
name: dihydroorotate dehydrogenase
name: Dihydroorotate dehydrogenase, mitochondrial precursor (EC 1.3.3.1) (Dihydroorotate oxidase) (DHOdehase) (Fragment)
name: P0A7E1
xref: UnificationXref2911
feature: FragmentFeature263
cellular location: intracellular
comment: Reactome DB_ID: 4231779
display name: DHODH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P21179
data source: Provenance1
name: Catalase apoprotein (EC 1.11.1.6)
name: P21179
name: Catalase
name: CATA_HUMAN
xref: UnificationXref2889
feature: FragmentFeature262
cellular location: intracellular
comment: Reactome DB_ID: 4231966
display name: CAT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P76641
data source: Provenance1
name: GAH
name: Guanase
name: Guanine deaminase
name: p51-nedasin
name: Guanine aminohydrolase
name: P76641
name: Guanine aminase
xref: UnificationXref2870
feature: FragmentFeature261
cellular location: intracellular
comment: Reactome DB_ID: 4231934
display name: GDA

http://identifiers.org/pubmed/18632300
type: PublicationXref
id: 18632300
author: den Hollander, Anneke I
author: Cremers, Frans P M
author: Roepman, Ronald
author: Koenekoop, Robert K
db: Pubmed
title: Leber congenital amaurosis: genes, proteins and disease mechanisms
source: Prog Retin Eye Res 27:391-419
year: 2008

http://identifiers.org/pubmed/18215067
type: PublicationXref
id: 18215067
author: Holmes, RP
author: Murray, MS
author: Lowther, WT
db: Pubmed
title: Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design
source: Biochemistry 47:2439-49
year: 2008

http://identifiers.org/pubmed/4358634
type: PublicationXref
id: 4358634
author: Roth, DG
author: Deuel, TF
author: Shelton, E
db: Pubmed
title: Purification and properties of phosphoribosyl pyrophosphate synthetase from rat liver
source: J Biol Chem 249:291-296
year: 1974

http://identifiers.org/pubmed/21479626
type: PublicationXref
id: 21479626
author: Sass, JO
db: Pubmed
title: Inborn errors of ketogenesis and ketone body utilization
source: J Inherit Metab Dis
year: 2011

Activation of Chaperone Genes by ATF6-alpha
type: Pathway
data source: Provenance1
pathway component: Expression of HSP90B1 (Endoplasmin)
evidence: Evidence158
xref: UnificationXref1120
xref: UnificationXref1119
pathway order: PathwayStep149
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

L-O-Phosphoserine
type: SmallMoleculeReference
name: O-Phospho-L-serine
name: 3-Phosphoserine
name: O-Phospho-L-serine [ChEBI:7692]
xref: UnificationXref3410

L-Kynurenine [ChEBI:16946]
type: SmallMoleculeReference
name: 3-Anthraniloyl-L-alanine
name: L-Kynurenine
xref: UnificationXref3469

http://identifiers.org/pubmed/19741254
type: PublicationXref
id: 19741254
author: Chicco, AJ
author: Sparagna, GC
author: Moore, RL
author: Zachman, DK
author: Murphy, RC
author: McCune, SA
db: Pubmed
title: The role of calcium-independent phospholipase A2 in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart
source: J Lipid Res 51:525-34
year: 2010

Stimuli-sensing channels
type: Pathway
data source: Provenance1
pathway component: SLC9C1 exchanges Na+ for H+
pathway component: SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol
pathway component: SLC17A3-2 transports cytosolic urate to extracellular region
evidence: Evidence113
xref: UnificationXref770
xref: UnificationXref769
pathway order: PathwayStep106
pathway order: PathwayStep105
pathway order: PathwayStep104
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/16865347
type: PublicationXref
id: 16865347
author: Gundelfinger, ED
author: Schoch, S
db: Pubmed
title: Molecular organization of the presynaptic active zone
source: Cell Tissue Res 326:379-91
year: 2006

UniProt:P76459
type: ProteinReference
xref: UnificationXref2026
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P08192
data source: Provenance1
name: Folylpolyglutamate synthase-2
name: P08192
name: FPGS isoform 2
name: FOLC_HUMAN
xref: UnificationXref3267
feature: FragmentFeature287
cellular location: intracellular
comment: Reactome DB_ID: 4232276
display name: FPGS-2

http://identifiers.org/pubmed/8283301
type: PublicationXref
id: 8283301
author: Rudolph, FB
db: Pubmed
title: The biochemistry and physiology of nucleotides
source: J Nutr 124:124S-127S
year: 1994

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P24186
data source: Provenance1
name: P24186
xref: UnificationXref3288
feature: FragmentFeature288
cellular location: intracellular
comment: Reactome DB_ID: 4232289
display name: MTHFD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AEZ1
data source: Provenance1
name: P0AEZ1
name: Methylenetetrahydrofolate reductase
xref: UnificationXref3303
feature: FragmentFeature289
cellular location: intracellular
comment: Reactome DB_ID: 4232297
display name: MTHFR

Catalysis249
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction282
control type: ACTIVATION
xref: RelationshipXref466
xref: RelationshipXref465
controller: DHFR

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P30745
data source: Provenance1
name: MOCS1-1
name: P30745
xref: UnificationXref3325
feature: FragmentFeature290
cellular location: intracellular
comment: Reactome DB_ID: 4232883
display name: MOCS1B

http://identifiers.org/pubmed/14988808
type: PublicationXref
id: 14988808
author: Jakobs, C
author: Huck, JH
author: Verhoeven, NM
author: van der Knaap, MS
author: Struys, EA
author: Salomons, GS
db: Pubmed
title: Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathy
source: Am J Hum Genet 74:745-51
year: 2004

UniProt:P76458
type: ProteinReference
xref: UnificationXref2024
organism: BioSource1

Catalysis243
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction274
control type: ACTIVATION
xref: RelationshipXref453
xref: RelationshipXref452
controller: Complex164

Catalysis244
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction275
control type: ACTIVATION
xref: RelationshipXref453
xref: RelationshipXref452
controller: Complex164

PNPO(1-216)
type: Protein
entity reference: UniProt:P0AFI7
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Pyridoxine-5'-phosphate oxidase
name: P0AFI7
xref: UnificationXref3203
feature: FragmentFeature282
cellular location: intracellular
comment: Reactome DB_ID: 4232919
display name: PNPO

Catalysis241
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction272
control type: ACTIVATION
xref: RelationshipXref450
xref: RelationshipXref451
controller: Complex163

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P24182
data source: Provenance1
name: Pyruvic carboxylase
name: Pyruvate carboxylase, mitochondrial precursor
name: P24182
name: pyruvate carboxylase
xref: UnificationXref3216
feature: ModificationFeature33
feature: FragmentFeature283
cellular location: intracellular
comment: Reactome DB_ID: 4233299
display name: Btn-PC

Catalysis242
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction273
control type: ACTIVATION
xref: RelationshipXref450
xref: RelationshipXref451
controller: Complex163

Catalysis247
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction280
control type: ACTIVATION
xref: RelationshipXref462
xref: RelationshipXref461
controller: PNCA_ECOLI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P30011
data source: Provenance1
name: Nicotinate-nucleotide pyrophosphorylase (carboxylating)
name: P30011
xref: UnificationXref3232
feature: FragmentFeature284
cellular location: intracellular
comment: Reactome DB_ID: 4232271
display name: QPRT

Catalysis248
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction281
control type: ACTIVATION
xref: RelationshipXref466
xref: RelationshipXref465
controller: DHFR

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A7B3
data source: Provenance1
name: P0A7B3
name: Putative inorganic polyphosphate/ATP-NAD kinase
name: PPNK_HUMAN
xref: UnificationXref3236
feature: FragmentFeature285
cellular location: intracellular
comment: Reactome DB_ID: 4232265
display name: NADK

PNCA_ECOLI
type: Protein
entity reference: P21369
data source: Provenance1
name: Pyrazinamidase/nicotinamidase
xref: UnificationXref3248
xref: UnificationXref3247
feature: FragmentFeature286
cellular location: GO:0005829
comment: Reactome DB_ID: 197272
display name: pncA

Catalysis245
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction278
control type: ACTIVATION
xref: RelationshipXref457
xref: RelationshipXref458
controller: Note: the coordinates are copied over from Homo sapiens.

DHFR
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3258
cellular location: intracellular
comment: Reactome DB_ID: 4232282
comment: Converted from EntitySet in Reactome

Catalysis246
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction279
control type: ACTIVATION
xref: RelationshipXref459
xref: RelationshipXref460
controller: Complex167

Catalysis251
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction284
control type: ACTIVATION
xref: RelationshipXref467
xref: RelationshipXref468
controller: Note: the coordinates are copied over from Homo sapiens.

http://identifiers.org/pubmed/14559994
type: PublicationXref
id: 14559994
author: Iwakoshi, NN
author: Lee, AH
author: Glimcher, LH
db: Pubmed
title: XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
source: Mol Cell Biol 23:7448-59
year: 2003

Catalysis250
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction283
control type: ACTIVATION
xref: RelationshipXref467
xref: RelationshipXref468
controller: Note: the coordinates are copied over from Homo sapiens.

http://identifiers.org/pubmed/22796206
type: PublicationXref
id: 22796206
author: Hausmann, George
author: Basler, Konrad
author: Herr, Patrick
db: Pubmed
title: WNT secretion and signalling in human disease
source: Trends Mol Med 18:483-93
year: 2012

http://identifiers.org/pubmed/13538944
type: PublicationXref
id: 13538944
author: Tsuboi, KK
author: Hudson, PB
author: Estrada, J
db: Pubmed
title: Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties.
source: J Biol Chem 231:19-29
year: 1958

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P30749
data source: Provenance1
name: SOG-MOCS2
name: MOCS2A-CO-S(1-)
xref: UnificationXref3353
feature: FragmentFeature298
feature: ModificationFeature36
cellular location: intracellular
comment: Reactome DB_ID: 4232891
display name: P30749

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A6B7
data source: Provenance1
name: P0A6B7
name: NSF1 isoform 2
xref: UnificationXref3345
feature: FragmentFeature296
cellular location: intracellular
comment: Reactome DB_ID: 4232869
display name: NFS1-2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P30749
data source: Provenance1
name: P30749
name: MOCS2A
xref: UnificationXref3350
feature: FragmentFeature297
cellular location: intracellular
comment: Reactome DB_ID: 4232889
display name: MOCS2

Homologues of MOCS3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3337
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232859

Catalysis252
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction285
control type: ACTIVATION
xref: RelationshipXref467
xref: RelationshipXref468
controller: Note: the coordinates are copied over from Homo sapiens.

Leukotriene C4
type: SmallMoleculeReference
name: Leukotriene C4 [ChEBI:6422]
xref: UnificationXref2321

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P30138
data source: Provenance1
name: MOCS3 (red.)
name: P30138
xref: UnificationXref3334
feature: FragmentFeature292
cellular location: intracellular
comment: Reactome DB_ID: 4232855
display name: MOCS3

Catalysis253
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction286
control type: ACTIVATION
xref: RelationshipXref469
xref: RelationshipXref470
controller: Complex168

L-Alanine [ChEBI:16977]
type: SmallMoleculeReference
name: L-alpha-Alanine
name: L-Alanine
name: L-2-Aminopropionic acid
xref: UnificationXref118

Catalysis254
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction287
control type: ACTIVATION
xref: RelationshipXref471
xref: RelationshipXref472
controller: Complex168

MOCS1-5
type: Protein
entity reference: UniProt:P30745
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P30745
xref: UnificationXref3329
feature: FragmentFeature291
cellular location: intracellular
comment: Reactome DB_ID: 4232882
display name: MOCS1A

Catalysis255
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction288
control type: ACTIVATION
xref: RelationshipXref474
xref: RelationshipXref473
controller: Complex168

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P30138
data source: Provenance1
name: CysS-MOCS3
name: MOCS3-S-S(1-)
xref: UnificationXref3340
feature: FragmentFeature294
feature: ModificationFeature34
cellular location: intracellular
comment: Reactome DB_ID: 4232862
display name: P30138

Catalysis256
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction289
control type: ACTIVATION
xref: RelationshipXref475
xref: RelationshipXref476
controller: Complex169

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P12282
data source: Provenance1
name: CysS-MOCS3
name: MOCS3-S-S(1-)
xref: UnificationXref3341
feature: ModificationFeature35
feature: FragmentFeature295
cellular location: intracellular
comment: Reactome DB_ID: 4232864
display name: P12282

Catalysis257
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction290
control type: ACTIVATION
xref: RelationshipXref474
xref: RelationshipXref473
controller: Complex168

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P12282
data source: Provenance1
name: MOCS3 (red.)
name: P12282
xref: UnificationXref3336
feature: FragmentFeature293
cellular location: intracellular
comment: Reactome DB_ID: 4232858
display name: MOCS3

Catalysis258
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction291
control type: ACTIVATION
xref: RelationshipXref471
xref: RelationshipXref472
controller: Complex168

Homologues of CysS-MOCS3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3342
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232865

Catalysis259
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction292
control type: ACTIVATION
xref: RelationshipXref479
xref: RelationshipXref478
controller: Complex170

Beta oxidation of octanoyl-CoA to hexanoyl-CoA
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction162
pathway component: BiochemicalReaction163
evidence: Evidence305
xref: UnificationXref1939
xref: UnificationXref1938
xref: RelationshipXref242
pathway order: PathwayStep291
pathway order: PathwayStep290
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/1670590
type: PublicationXref
id: 1670590
author: von Figura, K
author: Fluharty, CB
author: Kappler, J
author: Gieselmann, V
author: Fluharty, AL
author: Polten, A
db: Pubmed
title: Molecular basis of different forms of metachromatic leukodystrophy
source: N Engl J Med 324:18-22
year: 1991

Catalysis260
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction293
control type: ACTIVATION
xref: RelationshipXref480
xref: RelationshipXref481
controller: Complex173

ChEBI:16975 1-acyl-sn-glycerol 3-phosphate
type: SmallMoleculeReference
name: 1-acyl-sn-glycerol 3-phosphate
xref: UnificationXref1808

3-Ureidoisobutyrate
type: SmallMoleculeReference
name: 3-ureidoisobutyric acid
name: ChEBI:1670 3-ureidoisobutyric acid
xref: UnificationXref3030

UniProt:P26647
type: ProteinReference
xref: UnificationXref1828
organism: BioSource1

Catalysis262
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction295
control type: ACTIVATION
xref: RelationshipXref484
xref: RelationshipXref485
controller: Complex175

Catalysis261
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction294
control type: ACTIVATION
xref: RelationshipXref482
xref: RelationshipXref483
controller: Complex172

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P60546
data source: Provenance1
name: P60546
name: Guanylate kinase (EC 2.7.4.8) (GMP kinase)
name: GMP kinase
name: guanylate kinase 1
xref: UnificationXref3056
feature: FragmentFeature272
cellular location: intracellular
comment: Reactome DB_ID: 4231831
display name: GUK1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P00452
data source: Provenance1
name: P00452
name: Ribonucleoside-diphosphate reductase M1 chain (EC 1.17.4.1) (Ribonucleotide reductase large chain)
name: Ribonucleoside-diphosphate reductase M1 chain
name: ribonucleotide reductase M1 polypeptide
name: Ribonucleotide reductase large chain
xref: UnificationXref3080
feature: FragmentFeature273
cellular location: intracellular
comment: Reactome DB_ID: 4232112
display name: RRM1

Uridine monophosphokinase 2
type: Protein
entity reference: UniProt:P0A8F4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P0A8F4
name: Cytidine monophosphokinase 2
name: Uridine-cytidine kinase 2
name: UCK2(2-261)
xref: UnificationXref2986
feature: FragmentFeature268
cellular location: intracellular
comment: Reactome DB_ID: 4232038
display name: UCK 2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P25889
data source: Provenance1
name: P25889
name: Dihydropyrimidine dehydrogenase (NADP+)
name: DHPDHase
name: Dihydrouracil dehydrogenase
name: Dihydrothymine dehydrogenase
xref: UnificationXref3008
feature: FragmentFeature269
cellular location: intracellular
comment: Reactome DB_ID: 4231792
display name: DPYD

Q46806
type: Protein
entity reference: Q46806
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Dihydropyrimidinase
name: Hydantoinase
name: DPYS
name: DHPase
xref: UnificationXref3021
feature: FragmentFeature270
cellular location: intracellular
comment: Reactome DB_ID: 4231799
display name: DHP

http://identifiers.org/pubmed/14530973
type: PublicationXref
id: 14530973
author: Mackenzie, B
author: Hediger, MA
db: Pubmed
title: SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1
source: Pflugers Arch 447:571-9
year: 2004

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P69441
data source: Provenance1
name: Adenylate kinase isoenzyme 2, mitochondrial
name: adenylate kinase 2
name: P69441
name: ATP-AMP transphosphorylase
name: Adenylate kinase isoenzyme 2, mitochondrial (EC 2.7.4.3) (ATP-AMP transphosphorylase)
xref: UnificationXref3040
feature: FragmentFeature271
cellular location: intracellular
comment: Reactome DB_ID: 4232045
display name: AK2

Catalysis269
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction302
control type: ACTIVATION
xref: RelationshipXref498
xref: RelationshipXref497
controller: Complex184

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A7E3
data source: Provenance1
name: Orotate phosphoribosyltransferase
name: UMPS(2-480)
name: OMPdecase
name: OPRtase
name: UMP synthase
name: uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)
name: P0A7E3
name: Uridine 5'-monophosphate synthase
name: Uridine 5'-monophosphate synthase (UMP synthase) (Includes: Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRtase); Orotidine 5'- phosphate decarboxylase (EC 4.1.1.23) (OMPdecase))
name: Orotidine 5'- phosphate decarboxylase
xref: UnificationXref2922
feature: FragmentFeature264
cellular location: intracellular
comment: Reactome DB_ID: 4231771
display name: UMPS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P06968
data source: Provenance1
name: deoxyuridine triphosphatase isoform 2
name: P06968
name: dUTP pyrophosphatase
xref: UnificationXref2942
feature: FragmentFeature265
cellular location: intracellular
comment: Reactome DB_ID: 4231825
display name: DUT-2

Catalysis267
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction300
control type: ACTIVATION
xref: RelationshipXref493
xref: RelationshipXref494
controller: Complex182

Thymidine phosphorylase precursor
type: Protein
entity reference: UniProt:P07650
data source: Provenance1
name: Thymidine phosphorylase precursor (EC 2.4.2.4) (TdRPase) (TP) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (Gliostatin)
name: Note: the coordinates are copied over from Homo sapiens.
name: endothelial cell growth factor 1 (platelet-derived)
name: TYMP
name: PD-ECGF
name: TdRPase
name: thymidine phosphorylase
name: Gliostatin
name: P07650
name: Platelet-derived endothelial cell growth factor
xref: UnificationXref2971
feature: FragmentFeature266
cellular location: intracellular
comment: Reactome DB_ID: 4232143
display name: TP

Catalysis268
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction301
control type: ACTIVATION
xref: RelationshipXref496
xref: RelationshipXref495
controller: Complex183

UCK 1
type: Protein
entity reference: UniProt:P0A8F4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Uridine monophosphokinase 1
name: P0A8F4
name: Cytidine monophosphokinase 1
name: Uridine-cytidine kinase 1
xref: UnificationXref2982
feature: FragmentFeature267
cellular location: intracellular
comment: Reactome DB_ID: 4231805
display name: UCK1

Catalysis265
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction298
control type: ACTIVATION
xref: RelationshipXref190
xref: RelationshipXref189
controller: GOT2 dimer (name copied from entity in Homo sapiens)

Catalysis266
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction299
control type: ACTIVATION
xref: RelationshipXref492
xref: RelationshipXref491
controller: Complex179

Catalysis263
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction296
control type: ACTIVATION
xref: RelationshipXref487
xref: RelationshipXref486
controller: Complex177

Catalysis264
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction297
control type: ACTIVATION
xref: RelationshipXref191
xref: RelationshipXref189
controller: GOT1 dimer (name copied from entity in Homo sapiens)

Catalysis273
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction306
control type: ACTIVATION
xref: RelationshipXref345
xref: RelationshipXref344
controller: Complex117

Catalysis272
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction305
control type: ACTIVATION
xref: RelationshipXref503
xref: RelationshipXref504
controller: Complex186

Catalysis271
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction304
control type: ACTIVATION
xref: RelationshipXref503
xref: RelationshipXref504
controller: Complex186

Catalysis270
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction303
control type: ACTIVATION
xref: RelationshipXref499
xref: RelationshipXref500
controller: Complex185

http://identifiers.org/pubmed/18449172
type: PublicationXref
id: 18449172
author: Liepnieks, JJ
author: Scott, K
author: Kluve-Beckerman, B
author: James, S
author: Benson, MD
db: Pubmed
title: Leukocyte chemotactic factor 2: A novel renal amyloid protein
source: Kidney Int 74:218-22
year: 2008

http://identifiers.org/pubmed/13629198
type: PublicationXref
id: 13629198
author: McKusick, Victor A
db: Pubmed
title: Hereditary disorders of connective tissue
source: Bull N Y Acad Med 35:143-56
year: 1959

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P77150
data source: Provenance1
name: P77150
name: Pyridoxal kinase
xref: UnificationXref3179
feature: FragmentFeature281
cellular location: intracellular
comment: Reactome DB_ID: 4232910
display name: PDXK

Homologues of PDXK
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3180
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232911

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P40191
data source: Provenance1
name: P40191
name: Pyridoxal kinase
xref: UnificationXref3177
feature: FragmentFeature280
cellular location: intracellular
comment: Reactome DB_ID: 4232907
display name: PDXK

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P52061
data source: Provenance1
name: P52061
name: Inosine triphosphate pyrophosphatase
xref: UnificationXref3136
feature: FragmentFeature278
cellular location: intracellular
comment: Reactome DB_ID: 4233269
display name: ITPA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0ABQ0
data source: Provenance1
name: Phosphopantothenoylcysteine decarboxylase
name: P0ABQ0
name: COAC_HUMAN
xref: UnificationXref3165
feature: FragmentFeature279
cellular location: intracellular
comment: Reactome DB_ID: 4232259
display name: PPCDC

Catalysis278
type: Catalysis
data source: Provenance1
controlled: carbamoyl phosphate + ornithine => citrulline + orthophosphate
control type: ACTIVATION
xref: RelationshipXref515
xref: RelationshipXref516
controller: Complex189

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P69924
data source: Provenance1
name: P69924
name: ribonucleotide reductase M2B (TP53 inducible)
xref: UnificationXref3115
feature: FragmentFeature276
cellular location: intracellular
comment: Reactome DB_ID: 4232131
display name: RRM2B

Catalysis279
type: Catalysis
data source: Provenance1
controlled: ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate
control type: ACTIVATION
xref: RelationshipXref518
xref: RelationshipXref517
controller: Complex190

glutathione reductase
type: Protein
entity reference: UniProt:P06715
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: GSR isoform 2
name: GSR-2
name: GRase
name: P06715
name: GSHR_HUMAN
name: Glutathione reductase, mitochondrial precursor
xref: UnificationXref3122
feature: FragmentFeature277
cellular location: intracellular
comment: Reactome DB_ID: 4231754
display name: GR

Homologues of RRM2B
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3116
cellular location: intracellular
comment: Reactome DB_ID: 4232132
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P37146
data source: Provenance1
name: P37146
name: ribonucleotide reductase M2B (TP53 inducible)
xref: UnificationXref3114
feature: FragmentFeature275
cellular location: intracellular
comment: Reactome DB_ID: 4232130
display name: RRM2B

Catalysis274
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction307
control type: ACTIVATION
xref: RelationshipXref506
xref: RelationshipXref507
controller: Complex187

Catalysis275
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction308
control type: ACTIVATION
xref: RelationshipXref506
xref: RelationshipXref507
controller: Complex187

SASP
type: Protein
entity reference: UniProt:P0AGG4
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: ATL-derived factor
name: thioredoxin, oxidized
name: 2xHC-TXN
name: P0AGG4
name: Surface associated sulphydryl protein
xref: UnificationXref3111
feature: ModificationFeature32
feature: ModificationFeature31
feature: FragmentFeature274
cellular location: intracellular
comment: Reactome DB_ID: 4232129
display name: ADF

Catalysis276
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction309
control type: ACTIVATION
xref: RelationshipXref510
xref: RelationshipXref509
controller: Complex188

Catalysis277
type: Catalysis
data source: Provenance1
controlled: kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate
control type: ACTIVATION
xref: RelationshipXref512
xref: RelationshipXref513
controller: Complex186

Catalysis282
type: Catalysis
data source: Provenance1
controlled: Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine
control type: ACTIVATION
xref: RelationshipXref525
xref: RelationshipXref526
controller: Spermidine synthase

Catalysis281
type: Catalysis
data source: Provenance1
controlled: gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+
control type: ACTIVATION
xref: RelationshipXref522
xref: RelationshipXref523
controller: Complex192

Catalysis284
type: Catalysis
data source: Provenance1
controlled: glyoxylate + NADPH + H+ => glycolate + NADP+
control type: ACTIVATION
xref: RelationshipXref531
xref: RelationshipXref532
controller: Note: the coordinates are copied over from Homo sapiens.

Ethanedioic acid
type: SmallMoleculeReference
name: Oxalate
name: Oxalic acid
name: Oxalate [ChEBI:7811]
xref: UnificationXref3581

Catalysis283
type: Catalysis
data source: Provenance1
controlled: Transamination of MOB to methionine
control type: ACTIVATION
xref: RelationshipXref528
xref: RelationshipXref527
controller: GOT1 dimer (name copied from entity in Homo sapiens)

Catalysis280
type: Catalysis
data source: Provenance1
controlled: argininosuccinate <=> fumarate + arginine
control type: ACTIVATION
xref: RelationshipXref520
xref: RelationshipXref519
controller: Complex191

Innate Immune System
type: Pathway
data source: Provenance1
pathway component: REACT 153085.3
evidence: Evidence120
xref: RelationshipXref87
xref: UnificationXref791
xref: UnificationXref790
pathway order: PathwayStep112
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1313
type: UnificationXref
id: CHEBI:17709
db: ChEBI

UnificationXref1314
type: UnificationXref
id: 174370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174370

UnificationXref1311
type: UnificationXref
id: 174375
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174375

UnificationXref1312
type: UnificationXref
id: REACT_7206
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7206.3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P77567
data source: Provenance1
name: Arylamine N-acetyltransferase 2
name: P77567
xref: UnificationXref3753
feature: FragmentFeature328
cellular location: intracellular
comment: Reactome DB_ID: 4232150
display name: NAT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P77567
data source: Provenance1
name: Acyl-NAT2 intermediate
name: AcC-NAT2
xref: UnificationXref3755
feature: FragmentFeature329
feature: ModificationFeature40
cellular location: intracellular
comment: Reactome DB_ID: 4232152
display name: P77567

UnificationXref1310
type: UnificationXref
id: CHEBI:16189
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P76373
data source: Provenance1
name: P76373
name: UDP-glucose dehydrogenase
xref: UnificationXref3742
feature: FragmentFeature327
cellular location: intracellular
comment: Reactome DB_ID: 4232169
display name: UGDH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P36553
data source: Provenance1
name: P36553
name: HEM6_HUMAN
name: Coproporphyrinogen III oxidase, mitochondrial
name: CPOX(132-454)
xref: UnificationXref3689
feature: FragmentFeature322
cellular location: intracellular
comment: Reactome DB_ID: 4232220
display name: CPOX

P29680
type: Protein
entity reference: UniProt:P29680
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DCUP_HUMAN
name: Uroporphyrinogen III decarboxylase
xref: UnificationXref3664
feature: FragmentFeature321
cellular location: intracellular
comment: Reactome DB_ID: 4232226
display name: UROD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P06983
data source: Provenance1
name: HEM3_HUMAN
name: Porphobilinogen deaminase
name: P06983
xref: UnificationXref3653
feature: FragmentFeature320
cellular location: intracellular
comment: Reactome DB_ID: 4232214
display name: HMBS

UniProt:P0AER0
type: ProteinReference
xref: UnificationXref640
organism: BioSource1

P0ACB2
type: Protein
entity reference: UniProt:P0ACB2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: HEM2_HUMAN
name: Delta-aminolevulinic acid dehydratase
xref: UnificationXref3633
feature: FragmentFeature319
cellular location: intracellular
comment: Reactome DB_ID: 4232232
display name: ALAD

UnificationXref1319
type: UnificationXref
id: 4232177
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232177

P27550
type: Protein
entity reference: P27550
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: AceCS
name: Acyl-activating enzyme
name: Acetate--CoA ligase
name: Acetyl-coenzyme A synthetase, cytoplasmic
name: ACSS2
name: Acetyl-CoA synthetase
xref: UnificationXref3731
feature: FragmentFeature326
cellular location: intracellular
comment: Reactome DB_ID: 4231760
display name: ACS

UnificationXref1318
type: UnificationXref
id: 4232176
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232176

P27550
type: Protein
entity reference: P27550
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Acetyl-coenzyme A synthetase 2-like, mitochondrial
name: acyl-CoA synthetase short-chain family member 1
xref: UnificationXref3726
feature: FragmentFeature325
cellular location: intracellular
comment: Reactome DB_ID: 4232679
display name: ACSS1

UnificationXref1317
type: UnificationXref
id: 4232175
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232175

P0AEA5
type: Protein
entity reference: UniProt:P0AEA5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Protoheme IX farnesyltransferase, mitochondrial ecNumber2.5.1.-/ecNumber
name: COX10(?-443)
name: COX10_HUMAN
xref: UnificationXref3716
feature: FragmentFeature324
cellular location: intracellular
comment: Reactome DB_ID: 4233303
display name: COX10

UnificationXref1316
type: UnificationXref
id: P0A6J1
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P23871
data source: Provenance1
name: P23871
name: Ferrochelatase
name: HEMZ_HUMAN
xref: UnificationXref3702
feature: FragmentFeature323
cellular location: intracellular
comment: Reactome DB_ID: 4232238
display name: FECH

UnificationXref1315
type: UnificationXref
id: REACT_7820
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7820.2

http://identifiers.org/pubmed/16314626
type: PublicationXref
id: 16314626
author: Forastiere, AA
author: Goldwasser, MA
author: Eastern Cooperative Oncology, Group
author: Burtness, B
author: Mattar, B
author: Flood, W
db: Pubmed
title: Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study
source: J Clin Oncol 23:8646-54
year: 2005

UnificationXref1300
type: UnificationXref
id: REACT_121895
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121895.1

UnificationXref1301
type: UnificationXref
id: CHEBI:17411
db: ChEBI

UnificationXref1302
type: UnificationXref
id: 1678743
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1678743

UnificationXref1303
type: UnificationXref
id: REACT_122943
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122943.1

UnificationXref1309
type: UnificationXref
id: REACT_134319
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134319.5

UnificationXref1308
type: UnificationXref
id: 4233545
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233545

UniProt:P0AF43
type: ProteinReference
xref: UnificationXref419
organism: BioSource1

UnificationXref1305
type: UnificationXref
id: REACT_142054
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142054.5

UnificationXref1304
type: UnificationXref
id: 4233259
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233259

UnificationXref1307
type: UnificationXref
id: REACT_138927
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138927.5

UnificationXref1306
type: UnificationXref
id: 4233544
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233544

Bile acid and bile salt metabolism
type: Pathway
data source: Provenance1
pathway component: Synthesis of bile acids and bile salts
evidence: Evidence340
xref: UnificationXref2159
xref: UnificationXref2158
xref: RelationshipXref278
pathway order: PathwayStep326
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/15948717
type: PublicationXref
id: 15948717
author: Calamita, G
author: Agre, P
author: Nagase, H
author: Liu, K
author: Huang, CG
db: Pubmed
title: Purification and functional characterization of aquaporin-8
source: Biol Cell 98:153-61
year: 2006

Astrocytic Glutamate-Glutamine Uptake And Metabolism
type: Pathway
data source: Provenance1
pathway component: glutamate uptake by astrocytes
evidence: Evidence180
xref: UnificationXref1218
xref: UnificationXref1219
pathway order: PathwayStep169
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Glyoxylate metabolism
type: Pathway
data source: Provenance1
pathway component: Conversion of glyoxylate to oxalate
pathway component: glycolate + O2 => glyoxylate + H2O2
pathway component: glyoxylate + NADPH + H+ => glycolate + NADP+
evidence: Evidence543
xref: RelationshipXref537
xref: UnificationXref3587
xref: UnificationXref3586
pathway order: PathwayStep528
pathway order: PathwayStep530
pathway order: PathwayStep529
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

ATTY_HUMAN
type: Protein
entity reference: UniProt:P0A959
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Tyrosine aminotransferase
name: L-tyrosine:2-oxoglutarate aminotransferase
name: tyrosine aminotransferase
name: P0A959
name: PXLP-TAT
xref: UnificationXref3454
feature: ModificationFeature39
feature: FragmentFeature308
cellular location: intracellular
comment: Reactome DB_ID: 4231658
display name: TAT

UniProt:P25549
type: ProteinReference
xref: UnificationXref1379
organism: BioSource1

Homologues of PXLP-AADAT
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P77730
xref: UnificationXref3437
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231605

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AGB0
data source: Provenance1
name: P0AGB0
xref: UnificationXref3419
feature: FragmentFeature305
cellular location: intracellular
comment: Reactome DB_ID: 4232944
display name: PSPH

UniProt:P0AEP1
type: ProteinReference
xref: UnificationXref466
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P23721
data source: Provenance1
name: P23721
xref: UnificationXref3414
feature: FragmentFeature304
cellular location: intracellular
comment: Reactome DB_ID: 4232950
display name: PSAT1

D-3-phosphoglycerate dehydrogenase
type: Protein
entity reference: P0A9T0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P0A9T0
name: PHGHD
name: SERA_HUMAN
xref: UnificationXref3406
feature: FragmentFeature303
cellular location: intracellular
comment: Reactome DB_ID: 4232956
display name: PHGDH

ALDH18A1-2
type: Protein
entity reference: P07004
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ALDH18A1 short
name: Delta-1-pyrroline-5-carboxylate synthetase short
name: P5CS short
name: ALDH18A1 isoform 2
xref: UnificationXref3392
feature: FragmentFeature302
cellular location: intracellular
comment: Reactome DB_ID: 4232729
display name: P07004

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P07004
data source: Provenance1
name: ALDH18A1-1
name: ALDH18A1 long
name: P5CS long
name: Delta-1-pyrroline-5-carboxylate synthetase long
name: ALDH18A1 isoform 1
xref: UnificationXref3390
feature: FragmentFeature301
cellular location: intracellular
comment: Reactome DB_ID: 4232727
display name: P07004

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P12281
data source: Provenance1
name: P12281
xref: UnificationXref3371
feature: FragmentFeature300
cellular location: plasma membrane
comment: Reactome DB_ID: 4232875
display name: GPHN

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P30749
data source: Provenance1
name: MOCS2(1-188)
name: P30749
name: MOCS2B
xref: UnificationXref3356
feature: FragmentFeature299
cellular location: intracellular
comment: Reactome DB_ID: 4232895
display name: MOCS2

P77730
type: Protein
entity reference: UniProt:P77730
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: L-kynurenine/alpha-aminoadipate aminotransferase
name: PXLP-AADAT
xref: UnificationXref3436
feature: FragmentFeature307
feature: ModificationFeature38
cellular location: intracellular
comment: Reactome DB_ID: 4231604
display name: AADAT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P39389
data source: Provenance1
name: P39389
name: L-kynurenine/alpha-aminoadipate aminotransferase
name: PXLP-AADAT
xref: UnificationXref3434
feature: FragmentFeature306
feature: ModificationFeature37
cellular location: intracellular
comment: Reactome DB_ID: 4231600
display name: AADAT

http://identifiers.org/pubmed/14725767
type: PublicationXref
id: 14725767
author: Bate, M
author: Luke, RW
author: McAlister, MS
author: Ernill, RJ
author: Norman, RA
author: Paterson, DS
author: Barry, ST
author: Colls, JG
author: Tucker, JA
author: Breed, J
author: McCall, EJ
author: Minshull, CA
author: Timms, D
author: Pauptit, RA
author: McMiken, HH
db: Pubmed
title: Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor
source: Structure 12:75-84
year: 2004

UniProt:P0AEP9
type: ProteinReference
xref: UnificationXref2613
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P33232
data source: Provenance1
name: HAOX1
name: Hydroxyacid oxidase 1
name: P33232
xref: UnificationXref3576
feature: FragmentFeature317
cellular location: intracellular
comment: Reactome DB_ID: 4232482
display name: HAO1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P00935
data source: Provenance1
name: Cystathionine gamma-lyase
name: P00935
xref: UnificationXref3595
feature: FragmentFeature318
cellular location: intracellular
comment: Reactome DB_ID: 4233127
display name: CTH

UniProt:P25534
type: ProteinReference
xref: UnificationXref2475
organism: BioSource1

UniProt:P25535
type: ProteinReference
xref: UnificationXref2477
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P11447
data source: Provenance1
name: arginosuccinase
name: argininosuccinate lyase
name: P11447
xref: UnificationXref3513
feature: FragmentFeature313
cellular location: intracellular
comment: Reactome DB_ID: 4231540
display name: ASL

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A6E4
data source: Provenance1
name: argininosuccinic acid synthetase
name: Citrulline--aspartate ligase
name: P0A6E4
name: citrulline-aspartate ligase
name: argininosuccinate synthase
xref: UnificationXref3502
feature: FragmentFeature312
cellular location: intracellular
comment: Reactome DB_ID: 4231546
display name: ASS1

Spermidine synthase
type: Protein
entity reference: UniProt:P09158
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P09158
xref: UnificationXref3545
feature: FragmentFeature315
cellular location: intracellular
comment: Reactome DB_ID: 4232361
display name: SRM

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P17445
data source: Provenance1
name: 4-trimethylaminobutyraldehyde dehydrogenase
name: TMABADH
name: aldehyde dehydrogenase 9 family, member A1
name: ALDH9A1
xref: UnificationXref3526
feature: FragmentFeature314
cellular location: intracellular
comment: Reactome DB_ID: 4231664
display name: P17445

Homologues of OTC
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref3492
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231534

PUT2_HUMAN
type: Protein
entity reference: UniProt:P76217
data source: Provenance1
name: P5C dehydrogenase monomer
name: Note: the coordinates are copied over from Homo sapiens.
name: delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
name: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor
name: P5C dehydrogenase
name: ALDH4A1
xref: UnificationXref3463
feature: FragmentFeature309
cellular location: intracellular
comment: Reactome DB_ID: 4231593
display name: P76217

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P06960
data source: Provenance1
name: ornithine transcarbamylase
name: P06960
name: ornithine carbamoyltransferase, mitochondrial
xref: UnificationXref3491
feature: FragmentFeature311
cellular location: intracellular
comment: Reactome DB_ID: 4231533
display name: OTC

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P04391
data source: Provenance1
name: P04391
name: ornithine transcarbamylase
name: ornithine carbamoyltransferase, mitochondrial
xref: UnificationXref3489
feature: FragmentFeature310
cellular location: intracellular
comment: Reactome DB_ID: 4231530
display name: OTC

http://identifiers.org/pubmed/19278523
type: PublicationXref
id: 19278523
author: Dulhunty, Angela F
author: Wei, Lan
author: Beard, Nicole A
db: Pubmed
title: Control of muscle ryanodine receptor calcium release channels by proteins in the sarcoplasmic reticulum lumen
source: Clin. Exp. Pharmacol. Physiol. 36:340-5
year: 2009

mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction167
evidence: Evidence313
xref: UnificationXref1981
xref: RelationshipXref242
xref: UnificationXref1982
pathway order: PathwayStep299
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P37666
data source: Provenance1
name: P37666
name: Glyoxylate reductase/hydroxypyruvate reductase
xref: UnificationXref3570
feature: FragmentFeature316
cellular location: intracellular
comment: Reactome DB_ID: 4232477
display name: GRHPR

The canonical retinoid cycle in rods (twilight vision)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction12
evidence: Evidence18
xref: RelationshipXref15
xref: UnificationXref193
xref: UnificationXref192
pathway order: PathwayStep16
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Coenzyme QH2
type: SmallMoleculeReference
name: QH2
name: CoQH2
name: ubiquinol
name: ubiquinol [ChEBI:17976]
xref: UnificationXref2904

alpha-D-Galactose 1-phosphate [ChEBI:17973]
type: SmallMoleculeReference
name: alpha-D-Galactopyranose 1-phosphate
name: alpha-D-Galactose 1-phosphate
xref: UnificationXref1650

http://identifiers.org/pubmed/224930
type: PublicationXref
id: 224930
author: Inoue, K
author: Yamasawa, K
author: Nishimukai, H
db: Pubmed
title: Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes.
source: Biochim Biophys Acta 569:117-23
year: 1979

http://identifiers.org/pubmed/18436705
type: PublicationXref
id: 18436705
author: Scheuner, D
author: Kaufman, RJ
db: Pubmed
title: The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes
source: Endocr Rev 29:317-33
year: 2008

acyl-CoA
type: SmallMoleculeReference
name: acyl-CoA [ChEBI:2455]
xref: UnificationXref1822

Orotidine 5'-phosphate [ChEBI:15842]
type: SmallMoleculeReference
name: Orotidylic acid
name: Orotidine 5'-phosphate
xref: UnificationXref2918

http://identifiers.org/pubmed/22108505
type: PublicationXref
id: 22108505
author: Basler, Konrad
author: Herr, Patrick
db: Pubmed
title: Porcupine-mediated lipidation is required for Wnt recognition by Wls
source: Dev. Biol. 361:392-402
year: 2012

3'-Phospho-5'-adenylyl sulfate
type: SmallMoleculeReference
name: 3'-Phosphoadenosine 5'-phosphosulfate
name: 3'-Phosphoadenylyl sulfate [ChEBI:17980]
name: 3'-Phosphoadenylyl sulfate
name: PAPS
xref: UnificationXref1322

http://identifiers.org/pubmed/18757502
type: PublicationXref
id: 18757502
author: Kulik, W
author: Visser, WF
author: Boek, M
author: van Cruchten, A
author: van Roermund, CW
author: Waterham, HR
author: IJlst, L
author: Wanders, RJ
db: Pubmed
title: The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters
source: FASEB J 22:4201-8
year: 2008

Response to elevated platelet cytosolic Ca2+
type: Pathway
data source: Provenance1
pathway component: Platelet degranulation
evidence: Evidence124
xref: UnificationXref802
xref: UnificationXref801
pathway order: PathwayStep115
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

NAD
type: SmallMoleculeReference
name: NAD+ [ChEBI:15846]
name: DPN
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref1197

Chloride [ChEBI:17996]
type: SmallMoleculeReference
name: Chloride
xref: UnificationXref663

NADH
type: SmallMoleculeReference
name: NADH [ChEBI:16908]
xref: UnificationXref1203

Bromide
type: SmallMoleculeReference
name: Br-
name: Bromide [ChEBI:3178]
xref: UnificationXref660

UniProt:P0AET8
type: ProteinReference
xref: UnificationXref1976
organism: BioSource1

D-Fructose 1,6-bisphosphate
type: SmallMoleculeReference
name: D-Fructose 1,6-bisphosphate [ChEBI:16905]
xref: UnificationXref1455

Glucose metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 91053.9
pathway component: REACT 84301.9
pathway component: REACT 91535.9
pathway component: REACT 84145.9
evidence: Evidence257
xref: RelationshipXref197
xref: UnificationXref1648
xref: UnificationXref1649
pathway order: PathwayStep237
pathway order: PathwayStep225
pathway order: PathwayStep243
pathway order: PathwayStep235
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:P30749
type: ProteinReference
xref: UnificationXref3349
organism: BioSource1

http://identifiers.org/pubmed/22983114
type: PublicationXref
id: 22983114
author: Boutros, Michael
author: Bartscherer, Kerstin
author: Chaudhary, Varun
author: Gross, Julia Christina
db: Pubmed
title: Active Wnt proteins are secreted on exosomes
source: Nat. Cell Biol. 14:1036-45
year: 2012

UniProt:P30745
type: ProteinReference
xref: UnificationXref3324
organism: BioSource1

http://identifiers.org/pubmed/15546855
type: PublicationXref
id: 15546855
author: Loo, DD
author: Wright, EM
author: Hirayama, BA
author: Turk, E
db: Pubmed
title: Surprising versatility of Na+-glucose cotransporters: SLC5
source: Physiology (Bethesda) 19:370-6
year: 2004

UnificationXref224
type: UnificationXref
id: 446598
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446598

UnificationXref225
type: UnificationXref
id: REACT_21015
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21015.1

UnificationXref2419
type: UnificationXref
id: 4233263
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233263

UnificationXref222
type: UnificationXref
id: REACT_21207
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21207.2

UnificationXref223
type: UnificationXref
id: CHEBI:8428
db: ChEBI

UnificationXref2417
type: UnificationXref
id: 4233086
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233086

UnificationXref228
type: UnificationXref
id: REACT_20975
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20975.2

UnificationXref2418
type: UnificationXref
id: 4233039
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233039

UnificationXref229
type: UnificationXref
id: 446589
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446589

UnificationXref2415
type: UnificationXref
id: 4233034
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233034

UnificationXref226
type: UnificationXref
id: CHEBI:46020
db: ChEBI

UnificationXref2416
type: UnificationXref
id: 4233035
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233035

UnificationXref227
type: UnificationXref
id: 446599
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446599

http://identifiers.org/pubmed/20153287
type: PublicationXref
id: 20153287
author: Wallace, J C
author: Bailey, L M
author: Polyak, S W
db: Pubmed
title: Holocarboxylase synthetase: correlation of protein localisation with biological function
source: Arch. Biochem. Biophys. 496:45-52
year: 2010

UnificationXref220
type: UnificationXref
id: CHEBI:6801
db: ChEBI

UnificationXref221
type: UnificationXref
id: 446606
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446606

http://identifiers.org/pubmed/1270801
type: PublicationXref
id: 1270801
author: Franklin, EC
author: Rosenthal, CJ
author: Greenspan, J
author: Frangione, B
db: Pubmed
title: Isolation and partial characterization of SAA-an amyloid-related protein from human serum
source: J Immunol 116:1415-8
year: 1976

UnificationXref1249
type: UnificationXref
id: REACT_135708
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135708.5

UnificationXref1247
type: UnificationXref
id: REACT_131159
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131159.5

UnificationXref1248
type: UnificationXref
id: 4233480
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233480

CDP-DAG
type: SmallMoleculeReference
name: ChEBI:17962 CDP-DAG
xref: UnificationXref2193

UnificationXref1245
type: UnificationXref
id: REACT_127207
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127207.5

UnificationXref1246
type: UnificationXref
id: 4233479
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233479

UnificationXref1243
type: UnificationXref
id: REACT_138886
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138886.5

UnificationXref1244
type: UnificationXref
id: 4233478
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233478

UnificationXref1241
type: UnificationXref
id: REACT_140075
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140075.5

UnificationXref1242
type: UnificationXref
id: 4233477
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233477

UnificationXref2414
type: UnificationXref
id: 4233032
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233032

UnificationXref2413
type: UnificationXref
id: REACT_11819
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11819.2

UnificationXref1240
type: UnificationXref
id: 4233481
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233481

UnificationXref2412
type: UnificationXref
id: 111875
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111875

UnificationXref2411
type: UnificationXref
id: 4233038
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233038

UnificationXref2410
type: UnificationXref
id: 4233037
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233037

UnificationXref233
type: UnificationXref
id: 446609
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446609

UnificationXref234
type: UnificationXref
id: REACT_21081
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21081.2

UnificationXref235
type: UnificationXref
id: 446592
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446592

UnificationXref236
type: UnificationXref
id: REACT_21240
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21240.2

UnificationXref2426
type: UnificationXref
id: REACT_117170
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117170.1

UnificationXref237
type: UnificationXref
id: 446595
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446595

UnificationXref2427
type: UnificationXref
id: 4233041
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233041

UnificationXref238
type: UnificationXref
id: REACT_21171
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21171.2

UnificationXref2428
type: UnificationXref
id: REACT_126473
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126473.5

UnificationXref239
type: UnificationXref
id: 446603
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446603

UnificationXref2429
type: UnificationXref
id: 113519
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113519

http://identifiers.org/pubmed/8793927
type: PublicationXref
id: 8793927
author: Rosenthal, D I
author: Wang, Y
author: Dickersin, G R
author: Natowicz, M R
author: Gebhardt, M C
author: Sims, K B
author: Rosenberg, A E
author: Short, M P
db: Pubmed
title: Clinical and biochemical manifestations of hyaluronidase deficiency
source: N. Engl. J. Med. 335:1029-33
year: 1996

UnificationXref230
type: UnificationXref
id: REACT_21070
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21070.1

UnificationXref231
type: UnificationXref
id: 446607
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446607

UnificationXref232
type: UnificationXref
id: REACT_20771
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20771.2

UnificationXref1256
type: UnificationXref
id: 1217507
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1217507

UnificationXref1257
type: UnificationXref
id: REACT_116852
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116852.3

UnificationXref1258
type: UnificationXref
id: CHEBI:5292
db: ChEBI

UnificationXref1259
type: UnificationXref
id: 1217505
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1217505

UnificationXref1252
type: UnificationXref
id: CHEBI:64153
db: ChEBI

UnificationXref1253
type: UnificationXref
id: 1217506
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1217506

UnificationXref1254
type: UnificationXref
id: REACT_116266
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116266.1

UnificationXref1255
type: UnificationXref
id: CHEBI:65324
db: ChEBI

UnificationXref2423
type: UnificationXref
id: REACT_116759
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116759.1

UnificationXref2422
type: UnificationXref
id: 1606846
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1606846

UnificationXref2425
type: UnificationXref
id: 1606573
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1606573

UnificationXref1250
type: UnificationXref
id: 4232309
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232309

UnificationXref2424
type: UnificationXref
id: CHEBI:18390
db: ChEBI

UnificationXref1251
type: UnificationXref
id: 4232971
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232971

UnificationXref2421
type: UnificationXref
id: CHEBI:18318
db: ChEBI

UnificationXref2420
type: UnificationXref
id: REACT_136844
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136844.5

UnificationXref2439
type: UnificationXref
id: 1500625
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500625

UnificationXref2437
type: UnificationXref
id: 1609650
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1609650

UnificationXref248
type: UnificationXref
id: 4232659
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232659

UnificationXref2438
type: UnificationXref
id: REACT_117110
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117110.2

UnificationXref249
type: UnificationXref
id: 4232660
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232660

UnificationXref246
type: UnificationXref
id: REACT_20849
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20849.1

UnificationXref247
type: UnificationXref
id: P37340
db: UniProt

formamidopyrimidine
type: SmallMoleculeReference
name: 5-formamidopyrimidine
name: ChEBI:35877 5-formamidopyrimidine
xref: UnificationXref332

UnificationXref244
type: UnificationXref
id: REACT_20978
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20978.2

UnificationXref245
type: UnificationXref
id: 446597
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446597

UnificationXref242
type: UnificationXref
id: REACT_20887
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20887.1

UnificationXref243
type: UnificationXref
id: 446604
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446604

UnificationXref240
type: UnificationXref
id: REACT_20993
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20993.2

UnificationXref241
type: UnificationXref
id: 446596
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446596

UnificationXref1265
type: UnificationXref
id: 1217514
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1217514

UnificationXref1266
type: UnificationXref
id: REACT_117607
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117607.3

http://identifiers.org/pubmed/8650226
type: PublicationXref
id: 8650226
author: Neufeld, Elizabeth F
author: Li, HH
author: Zhao, HG
author: Bach, G
author: Schmidtchen, A
db: Pubmed
title: The molecular basis of Sanfilippo syndrome type B
source: Proc Natl Acad Sci U S A 93:6101-5
year: 1996

UnificationXref1263
type: UnificationXref
id: REACT_117054
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117054.2

UnificationXref1264
type: UnificationXref
id: CHEBI:71956
db: ChEBI

http://identifiers.org/pubmed/19783045
type: PublicationXref
id: 19783045
author: Kongsuphol, Patthara
author: Kunzelmann, Karl
author: Schreiber, Rainer
author: Warth, R
author: Tian, Yuemin
author: Ousingsawat, Jiraporn
author: Aldehni, Fadi
db: Pubmed
title: Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions
source: Cell Calcium 46:233-41
year: 2009

UnificationXref1269
type: UnificationXref
id: 4232972
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232972

UnificationXref1267
type: UnificationXref
id: 1217511
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1217511

UnificationXref1268
type: UnificationXref
id: REACT_117275
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117275.1

UnificationXref2432
type: UnificationXref
id: 1609648
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1609648

UnificationXref2431
type: UnificationXref
id: CHEBI:16814
db: ChEBI

UnificationXref2430
type: UnificationXref
id: REACT_3165
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3165.1

http://identifiers.org/pubmed/3893466
type: PublicationXref
id: 3893466
author: Jornvall, H
db: Pubmed
title: Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes
source: Alcohol 2:61-6
year: 1985

UnificationXref2436
type: UnificationXref
id: CHEBI:28689
db: ChEBI

UnificationXref1261
type: UnificationXref
id: CHEBI:5674
db: ChEBI

UnificationXref2435
type: UnificationXref
id: REACT_116361
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116361.1

UnificationXref1262
type: UnificationXref
id: 1217510
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1217510

UnificationXref2434
type: UnificationXref
id: 1609649
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1609649

UnificationXref2433
type: UnificationXref
id: REACT_117619
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117619.2

UnificationXref1260
type: UnificationXref
id: REACT_117645
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117645.1

UnificationXref2448
type: UnificationXref
id: 4233516
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233516

UnificationXref259
type: UnificationXref
id: 4232087
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232087

UnificationXref2449
type: UnificationXref
id: REACT_129989
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129989.5

UnificationXref255
type: UnificationXref
id: 4230340
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230340

UnificationXref256
type: UnificationXref
id: P17802
db: UniProt

UnificationXref257
type: UnificationXref
id: 4232085
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232085

UnificationXref258
type: UnificationXref
id: 4232086
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232086

UnificationXref251
type: UnificationXref
id: 4232663
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232663

UnificationXref252
type: UnificationXref
id: REACT_112833
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112833.8

UnificationXref253
type: UnificationXref
id: 4233459
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233459

UnificationXref254
type: UnificationXref
id: REACT_112371
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112371.8

UnificationXref250
type: UnificationXref
id: 4232661
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232661

UnificationXref1274
type: UnificationXref
id: 4233495
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233495

Decanoyl-CoA
type: SmallMoleculeReference
name: Decanoyl-CoA [ChEBI:28493]
xref: UnificationXref1897

UnificationXref1275
type: UnificationXref
id: REACT_132813
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132813.5

Diphosphatidylglycerol
type: SmallMoleculeReference
name: cardiolipin
name: cardiolipin [ChEBI:28494]
name: cardiolipins
name: 1',3'-Bis(1,2-diacyl-sn-glycero-3-phospho)-sn-glycerol
xref: UnificationXref2213

UnificationXref1276
type: UnificationXref
id: P76341
db: UniProt

UnificationXref1277
type: UnificationXref
id: 4232926
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232926

UnificationXref1278
type: UnificationXref
id: 4232927
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232927

UnificationXref1279
type: UnificationXref
id: 4232929
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232929

http://identifiers.org/pubmed/8662720
type: PublicationXref
id: 8662720
author: Korenberg, J
author: Garrow, TA
author: Qi, H
author: Choi, YJ
author: Shane, B
author: Chen, L
db: Pubmed
title: Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
source: J Biol Chem 271:13077-87
year: 1996

Glycerophospholipid biosynthesis
type: Pathway
data source: Provenance1
pathway component: REACT 142808.5
pathway component: REACT 133041.5
pathway component: REACT 128297.5
pathway component: Synthesis of PG
evidence: Evidence351
xref: UnificationXref2221
xref: RelationshipXref292
xref: UnificationXref2222
pathway order: PathwayStep333
pathway order: PathwayStep337
pathway order: PathwayStep331
pathway order: PathwayStep335
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2441
type: UnificationXref
id: 4233043
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233043

UnificationXref2440
type: UnificationXref
id: REACT_117549
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117549.1

UnificationXref2443
type: UnificationXref
id: 4233046
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233046

UnificationXref2442
type: UnificationXref
id: 4233045
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233045

UnificationXref2445
type: UnificationXref
id: 4233049
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233049

UnificationXref1270
type: UnificationXref
id: 4232973
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232973

UniProt:P45563
type: ProteinReference
xref: UnificationXref2804
organism: BioSource1

UnificationXref2444
type: UnificationXref
id: 4233047
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233047

UnificationXref1271
type: UnificationXref
id: REACT_127896
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127896.5

UnificationXref2447
type: UnificationXref
id: 4233050
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233050

UnificationXref1272
type: UnificationXref
id: 4233494
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233494

http://identifiers.org/pubmed/14500886
type: PublicationXref
id: 14500886
author: Green, S
author: Warrington, JA
author: Davis, S
author: Wolfe, CL
author: Norcum, MT
db: Pubmed
title: Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII
source: Protein Sci 12:2282-90
year: 2003

UnificationXref2446
type: UnificationXref
id: REACT_135756
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135756.5

UnificationXref1273
type: UnificationXref
id: REACT_131807
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131807.5

UnificationXref1209
type: UnificationXref
id: REACT_126787
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126787.5

UnificationXref1207
type: UnificationXref
id: 4232782
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232782

alpha-D-Glucose [ChEBI:17925]
type: SmallMoleculeReference
name: alpha-D-Glucose
xref: UnificationXref448

UnificationXref1208
type: UnificationXref
id: 4232784
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232784

UnificationXref1205
type: UnificationXref
id: REACT_2390
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2390.1

UnificationXref1206
type: UnificationXref
id: P25526
db: UniProt

UnificationXref2459
type: UnificationXref
id: 2162207
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162207

UnificationXref3589
type: UnificationXref
id: 1614518
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614518

UnificationXref2457
type: UnificationXref
id: REACT_160368
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160368.1

UnificationXref3588
type: UnificationXref
id: CHEBI:17482
db: ChEBI

UnificationXref2458
type: UnificationXref
id: CHEBI:64136
db: ChEBI

UnificationXref2455
type: UnificationXref
id: CHEBI:30763
db: ChEBI

UnificationXref2456
type: UnificationXref
id: 2162213
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162213

UnificationXref3585
type: UnificationXref
id: REACT_113190
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113190.8

UnificationXref2453
type: UnificationXref
id: 2162214
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162214

UnificationXref3584
type: UnificationXref
id: 4232488
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232488

UnificationXref2454
type: UnificationXref
id: REACT_161199
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161199.1

UnificationXref3587
type: UnificationXref
id: REACT_97620
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97620.9

UnificationXref2451
type: UnificationXref
id: REACT_112370
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112370.8

UnificationXref3586
type: UnificationXref
id: 4233446
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233446

UnificationXref2452
type: UnificationXref
id: CHEBI:61011
db: ChEBI

UnificationXref3581
type: UnificationXref
id: CHEBI:16995
db: ChEBI

UnificationXref1204
type: UnificationXref
id: 29362
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29362

UnificationXref3580
type: UnificationXref
id: REACT_113493
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113493.8

UnificationXref2450
type: UnificationXref
id: 4233517
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233517

UnificationXref1203
type: UnificationXref
id: CHEBI:16908
db: ChEBI

UnificationXref3583
type: UnificationXref
id: REACT_18181
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18181.2

UnificationXref1202
type: UnificationXref
id: REACT_2775
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2775.2

UnificationXref3582
type: UnificationXref
id: 389819
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389819

UnificationXref1201
type: UnificationXref
id: 113536
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113536

(5Z,8Z,10E,14Z)-(12R)-12-Hydroperoxyeicosa-5,8,10,14-tetraenoic acid
type: SmallMoleculeReference
name: (5Z,8Z,10E,14Z)-(12R)-12-Hydroperoxyicosa-5,8,10,14-tetraenoic acid
name: 12(R)-HPETE [ChEBI:34145]
name: 12(R)-HPETE
xref: UnificationXref2374

UnificationXref1200
type: UnificationXref
id: CHEBI:15741
db: ChEBI

12(S)-hydroxyeicosatetraenoic acid
type: SmallMoleculeReference
name: 12S-HETE
name: 12(S)-HETE
name: 12(S)-hydroxy-5,8,14(Z),10(E)-eicosatetraenoic acid
name: (5Z,8Z,10E,14Z)-(12S)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid
name: 12(S)-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid
name: (5Z,8Z,10E,14Z)-(12S)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid
name: (5Z,8Z,10E,12S,14Z)-12-hydroxyeicosa-5,8,10,14-tetraenoic acid
name: 12(S)-HETE [ChEBI:34146]
name: (12S)-12-hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid
xref: UnificationXref2385

12(R)-hydroxyeicosatetraenoic acid
type: SmallMoleculeReference
name: (5Z,8Z,10E,12R,14Z)-12-hydroxy-5,8,10,14-eicosatetraenoic acid
name: 12(R)-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid
name: 12(R)-HETE
name: 12(R)-hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid
name: (5Z,8Z,10E,14Z)-(12R)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid
name: (5Z,8Z,10E,14Z)-(12R)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid
name: (5Z,8Z,10E,12R,14Z)-12-hydroxyeicosa-5,8,10,14-tetraenoic acid
name: 12R-HETE
name: 12(R)-HETE [ChEBI:34144]
xref: UnificationXref2377

http://identifiers.org/pubmed/16435184
type: PublicationXref
id: 16435184
author: Ten Brink, HJ
author: Jakobs, C
author: Gibson, KM
author: Verhoeven, NM
author: Struys, EA
author: Wickenhagen, WV
db: Pubmed
title: Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias
source: J Inherit Metab Dis 28:921-30
year: 2005

Aquaporin-mediated transport
type: Pathway
data source: Provenance1
pathway component: Regulation of Water Balance by Renal Aquaporins
pathway component: REACT 112337.8
pathway component: Transport of Glycerol from Adipocytes to the Liver by Aquaporins
evidence: Evidence109
xref: RelationshipXref72
xref: UnificationXref736
xref: UnificationXref735
pathway order: PathwayStep99
pathway order: PathwayStep93
pathway order: PathwayStep102
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11604561
type: PublicationXref
id: 11604561
author: Cattaneo, M
author: Ruggeri, ZM
author: Savage, B
db: Pubmed
title: Mechanisms of platelet aggregation
source: Curr Opin Hematol 8:270-6
year: 2001

UnificationXref1216
type: UnificationXref
id: 4232332
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232332

UnificationXref1217
type: UnificationXref
id: 4232334
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232334

UnificationXref1218
type: UnificationXref
id: 4233429
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233429

UnificationXref1219
type: UnificationXref
id: REACT_105176
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105176.9

http://identifiers.org/pubmed/12397064
type: PublicationXref
id: 12397064
author: Ren, Y
author: Schulz, H
db: Pubmed
title: Metabolic functions of the two pathways of oleate beta-oxidation double bond metabolism during the beta-oxidation of oleic acid in rat heart mitochondria
source: J Biol Chem 278:111-6
year: 2003

http://identifiers.org/pubmed/14636670
type: PublicationXref
id: 14636670
author: Pereira, SL
author: Leonard, AE
author: Huang, YS
author: Sprecher, H
db: Pubmed
title: Elongation of long-chain fatty acids
source: Prog Lipid Res 43:36-54
year: 2004

UnificationXref2466
type: UnificationXref
id: REACT_5633
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5633.1

UnificationXref2467
type: UnificationXref
id: CHEBI:15379
db: ChEBI

http://identifiers.org/pubmed/16746585
type: PublicationXref
id: 16746585
author: Salvin, E
author: Johnson, WA
author: Krebs, HA
db: Pubmed
title: The formation of citric and alpha-ketoglutaric acids in the mammalian body
source: Biochem J 32:113-117
year: 1938

UnificationXref2468
type: UnificationXref
id: 113533
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113533

UnificationXref3599
type: UnificationXref
id: 4233519
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233519

UnificationXref2469
type: UnificationXref
id: REACT_2551
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2551.2

UnificationXref3598
type: UnificationXref
id: REACT_144243
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144243.5

UnificationXref2462
type: UnificationXref
id: 4233254
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233254

UnificationXref3597
type: UnificationXref
id: 4233133
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233133

UnificationXref2463
type: UnificationXref
id: 4233256
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233256

UnificationXref3596
type: UnificationXref
id: 4233128
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233128

UnificationXref2464
type: UnificationXref
id: REACT_163019
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_163019.2

UnificationXref3595
type: UnificationXref
id: 4233127
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233127

UnificationXref2465
type: UnificationXref
id: 113600
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113600

UnificationXref3594
type: UnificationXref
id: P00935
db: UniProt

UnificationXref1213
type: UnificationXref
id: REACT_139534
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139534.5

UnificationXref3593
type: UnificationXref
id: REACT_27614
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27614.3

UnificationXref1212
type: UnificationXref
id: 4233487
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233487

UnificationXref3592
type: UnificationXref
id: 936714
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936714

UnificationXref2460
type: UnificationXref
id: REACT_160757
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160757.1

UnificationXref1215
type: UnificationXref
id: REACT_99398
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99398.9

UnificationXref3591
type: UnificationXref
id: CHEBI:30831
db: ChEBI

UnificationXref2461
type: UnificationXref
id: P0AGK1
db: UniProt

UnificationXref1214
type: UnificationXref
id: 4233322
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233322

UnificationXref3590
type: UnificationXref
id: REACT_116259
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116259.1

UnificationXref1211
type: UnificationXref
id: REACT_127715
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127715.5

UnificationXref1210
type: UnificationXref
id: 4233486
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233486

UnificationXref1229
type: UnificationXref
id: 4232116
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232116

UnificationXref1227
type: UnificationXref
id: 4232281
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232281

http://identifiers.org/pubmed/8618861
type: PublicationXref
id: 8618861
author: Nevins, JR
author: DeGregori, J
author: Ohtani, K
db: Pubmed
title: Regulation of the cyclin E gene by transcription factor E2F1
source: Proc Natl Acad Sci U S A 92:12146-50
year: 1995

UnificationXref1228
type: UnificationXref
id: P37146
db: UniProt

http://identifiers.org/pubmed/22210669
type: PublicationXref
id: 22210669
author: Muenzer, J
db: Pubmed
title: Overview of the mucopolysaccharidoses
source: Rheumatology (Oxford) 50:v4-12
year: 2011

UnificationXref207
type: UnificationXref
id: REACT_155339
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155339.3

UnificationXref206
type: UnificationXref
id: 4233433
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233433

UnificationXref205
type: UnificationXref
id: REACT_158307
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158307.3

Sulfur
type: SmallMoleculeReference
name: Sulfur, precipitated
name: S
name: Sulfur [ChEBI:17909]
xref: UnificationXref2645

UnificationXref204
type: UnificationXref
id: 4233432
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233432

UnificationXref203
type: UnificationXref
id: REACT_158483
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158483.3

UnificationXref202
type: UnificationXref
id: 4233431
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233431

UnificationXref201
type: UnificationXref
id: REACT_159523
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159523.3

UnificationXref200
type: UnificationXref
id: 4232164
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232164

UnificationXref2475
type: UnificationXref
id: P25534
db: UniProt

UnificationXref2476
type: UnificationXref
id: 4233236
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233236

UnificationXref2473
type: UnificationXref
id: 113563
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113563

UnificationXref2474
type: UnificationXref
id: REACT_5783
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5783.1

UnificationXref2479
type: UnificationXref
id: P75728
db: UniProt

UnificationXref2477
type: UnificationXref
id: P25535
db: UniProt

UnificationXref208
type: UnificationXref
id: CHEBI:641
db: ChEBI

UnificationXref2478
type: UnificationXref
id: 4233239
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233239

UnificationXref209
type: UnificationXref
id: 446590
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446590

UnificationXref1222
type: UnificationXref
id: 4233323
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233323

UnificationXref1221
type: UnificationXref
id: REACT_97192
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97192.9

UnificationXref1220
type: UnificationXref
id: 4233430
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233430

Metabolism of nucleotides
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction267
pathway component: Synthesis and interconversion of nucleotide di- and triphosphates
pathway component: BiochemicalReaction268
pathway component: BiochemicalReaction269
pathway component: Purine metabolism
pathway component: REACT 29344.10
evidence: Evidence472
xref: UnificationXref3156
xref: RelationshipXref445
xref: UnificationXref3157
pathway order: PathwayStep455
pathway order: PathwayStep445
pathway order: PathwayStep457
pathway order: PathwayStep458
pathway order: PathwayStep456
pathway order: PathwayStep427
display name: Nucleotide metabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

L-Argininosuccinate
type: SmallMoleculeReference
name: N(omega)-(L-Arginino)succinate
name: N-(L-Arginino)succinate [ChEBI:15682]
name: L-Argininosuccinic acid
name: N-(L-Arginino)succinate
name: L-Arginosuccinic acid
xref: UnificationXref3498

UnificationXref2471
type: UnificationXref
id: 2162209
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162209

UnificationXref1226
type: UnificationXref
id: P0ABQ4
db: UniProt

UnificationXref2472
type: UnificationXref
id: REACT_160379
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160379.1

UnificationXref1225
type: UnificationXref
id: REACT_33434
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33434.10

UnificationXref1224
type: UnificationXref
id: 4233324
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233324

http://identifiers.org/pubmed/22210670
type: PublicationXref
id: 22210670
author: Underhill, Lisa
author: Miller, Nicole
author: Lehman, Thomas J A
author: Keutzer, Joan
author: Norquist, Becky
db: Pubmed
title: Diagnosis of the mucopolysaccharidoses
source: Rheumatology (Oxford) 50:v41-8
year: 2011

UnificationXref2470
type: UnificationXref
id: CHEBI:50775
db: ChEBI

UnificationXref1223
type: UnificationXref
id: REACT_106168
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106168.9

UnificationXref1238
type: UnificationXref
id: 4233476
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233476

UnificationXref1239
type: UnificationXref
id: REACT_137664
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137664.5

UnificationXref210
type: UnificationXref
id: REACT_21137
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21137.2

UnificationXref216
type: UnificationXref
id: REACT_2577
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2577.2

UnificationXref215
type: UnificationXref
id: 30733
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30733

UnificationXref218
type: UnificationXref
id: 446594
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446594

UnificationXref217
type: UnificationXref
id: CHEBI:42820
db: ChEBI

UnificationXref212
type: UnificationXref
id: 446602
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=446602

UnificationXref211
type: UnificationXref
id: CHEBI:3699
db: ChEBI

UnificationXref214
type: UnificationXref
id: CHEBI:16737
db: ChEBI

UnificationXref213
type: UnificationXref
id: REACT_21065
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21065.2

UnificationXref2484
type: UnificationXref
id: 4233244
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233244

UnificationXref2485
type: UnificationXref
id: 4233246
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233246

UnificationXref2486
type: UnificationXref
id: REACT_162713
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_162713.2

UnificationXref2487
type: UnificationXref
id: CHEBI:15414
db: ChEBI

UnificationXref2488
type: UnificationXref
id: 2162265
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162265

UnificationXref219
type: UnificationXref
id: REACT_21154
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21154.2

UnificationXref2489
type: UnificationXref
id: REACT_160998
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160998.1

http://identifiers.org/pubmed/9461603
type: PublicationXref
id: 9461603
author: Aguado, B
author: Campbell, RD
db: Pubmed
title: Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex
source: J Biol Chem 273:4096-105
year: 1998

UnificationXref1231
type: UnificationXref
id: 4232119
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232119

UnificationXref1230
type: UnificationXref
id: P69924
db: UniProt

UnificationXref1233
type: UnificationXref
id: P0A884
db: UniProt

UnificationXref1232
type: UnificationXref
id: 4232120
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232120

UnificationXref2480
type: UnificationXref
id: 4233242
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233242

UnificationXref1235
type: UnificationXref
id: 4232753
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232753

UnificationXref2481
type: UnificationXref
id: 4233243
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233243

UnificationXref1234
type: UnificationXref
id: 4231811
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231811

UnificationXref2482
type: UnificationXref
id: 113597
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113597

UnificationXref1237
type: UnificationXref
id: REACT_138375
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138375.5

UnificationXref2483
type: UnificationXref
id: REACT_3156
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3156.1

UnificationXref1236
type: UnificationXref
id: 4232754
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232754

UnificationXref2492
type: UnificationXref
id: REACT_161327
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161327.1

UnificationXref2491
type: UnificationXref
id: 2162252
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162252

UniProt:P22106
type: ProteinReference
xref: UnificationXref1131
organism: BioSource1

UnificationXref2494
type: UnificationXref
id: 2162215
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162215

UnificationXref2493
type: UnificationXref
id: CHEBI:50776
db: ChEBI

Catalysis240
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction271
control type: ACTIVATION
xref: RelationshipXref450
xref: RelationshipXref451
controller: Complex163

UnificationXref2490
type: UnificationXref
id: CHEBI:16680
db: ChEBI

UnificationXref3546
type: UnificationXref
id: 4232363
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232363

UnificationXref3547
type: UnificationXref
id: REACT_96311
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96311.9

UnificationXref2499
type: UnificationXref
id: REACT_161842
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161842.2

UnificationXref3544
type: UnificationXref
id: P09158
db: UniProt

UnificationXref3545
type: UnificationXref
id: 4232361
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232361

UnificationXref3542
type: UnificationXref
id: 353106
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=353106

UnificationXref2496
type: UnificationXref
id: P17993
db: UniProt

UnificationXref3543
type: UnificationXref
id: REACT_14918
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14918.2

UnificationXref2495
type: UnificationXref
id: REACT_160433
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160433.1

UnificationXref3540
type: UnificationXref
id: REACT_13241
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13241.2

UnificationXref2498
type: UnificationXref
id: 4233258
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233258

UnificationXref3541
type: UnificationXref
id: CHEBI:17509
db: ChEBI

UnificationXref2497
type: UnificationXref
id: 4233231
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233231

Catalysis239
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction270
control type: ACTIVATION
xref: RelationshipXref447
xref: RelationshipXref446
controller: Complex162

Catalysis238
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction269
control type: ACTIVATION
xref: RelationshipXref444
xref: RelationshipXref443
controller: Complex161

UnificationXref3549
type: UnificationXref
id: CHEBI:16723
db: ChEBI

http://identifiers.org/pubmed/11051212
type: PublicationXref
id: 11051212
author: Szkopinska, A
db: Pubmed
title: Ubiquinone. Biosynthesis of quinone ring and its isoprenoid side chain. Intracellular localization
source: Acta Biochim Pol 47:469-80
year: 2000

UnificationXref3548
type: UnificationXref
id: 4231107
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231107

Catalysis233
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction262
control type: ACTIVATION
xref: RelationshipXref432
xref: RelationshipXref433
controller: Complex155

Catalysis232
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction261
control type: ACTIVATION
xref: RelationshipXref430
xref: RelationshipXref431
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis231
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction260
control type: ACTIVATION
xref: RelationshipXref430
xref: RelationshipXref431
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis230
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction259
control type: ACTIVATION
xref: RelationshipXref429
xref: RelationshipXref428
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis237
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction268
control type: ACTIVATION
xref: RelationshipXref441
xref: RelationshipXref442
controller: Complex161

Catalysis236
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction267
control type: ACTIVATION
xref: RelationshipXref440
xref: RelationshipXref439
controller: Complex161

Catalysis235
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction264
control type: ACTIVATION
xref: RelationshipXref437
xref: RelationshipXref436
controller: Complex160

Catalysis234
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction263
control type: ACTIVATION
xref: RelationshipXref434
xref: RelationshipXref435
controller: Complex158

UnificationXref3550
type: UnificationXref
id: 1237122
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1237122

UnificationXref3555
type: UnificationXref
id: 4233498
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233498

UnificationXref3556
type: UnificationXref
id: REACT_147314
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147314.5

http://identifiers.org/pubmed/7542884
type: PublicationXref
id: 7542884
author: Stambolian, D
author: Ai, Y
author: Bergsma, DJ
author: Basu, M
db: Pubmed
title: Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2
source: Biochem Biophys Res Commun 212:687-91
year: 1995

http://identifiers.org/pubmed/18043707
type: PublicationXref
id: 18043707
author: Hamm, HE
author: Oldham, WM
db: Pubmed
title: Heterotrimeric G protein activation by G-protein-coupled receptors
source: Nat Rev Mol Cell Biol 9:60-71
year: 2008

UnificationXref3557
type: UnificationXref
id: 4233436
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233436

UnificationXref3558
type: UnificationXref
id: REACT_30589
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30589.10

UnificationXref3551
type: UnificationXref
id: REACT_76120
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_76120.1

UnificationXref3552
type: UnificationXref
id: 4231108
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231108

UnificationXref3553
type: UnificationXref
id: 4232977
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232977

UnificationXref3554
type: UnificationXref
id: REACT_132445
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132445.5

Catalysis228
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction257
control type: ACTIVATION
xref: RelationshipXref425
xref: RelationshipXref424
controller: Complex154

Catalysis227
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction256
control type: ACTIVATION
xref: RelationshipXref422
xref: RelationshipXref423
controller: Complex153

Catalysis229
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction258
control type: ACTIVATION
xref: RelationshipXref429
xref: RelationshipXref428
controller: Note: the coordinates are copied over from Homo sapiens.

UnificationXref3559
type: UnificationXref
id: 193465
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193465

http://identifiers.org/pubmed/3790084
type: PublicationXref
id: 3790084
author: Casazza, JP
author: Veech, RL
db: Pubmed
title: The content of pentose-cycle intermediates in liver in starved, fed ad libitum and meal-fed rats.
source: Biochem J 236:635-41
year: 1987

http://identifiers.org/pubmed/19204114
type: PublicationXref
id: 19204114
author: Schlessinger, Karni
author: Tolwinski, Nicholas
author: Hall, Alan
db: Pubmed
title: Wnt signaling pathways meet Rho GTPases
source: Genes Dev. 23:265-77
year: 2009

Catalysis220
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction249
control type: ACTIVATION
xref: RelationshipXref416
xref: RelationshipXref417
controller: Complex150

Catalysis222
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction251
control type: ACTIVATION
xref: RelationshipXref418
xref: RelationshipXref420
controller: Complex152

Catalysis221
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction250
control type: ACTIVATION
xref: RelationshipXref418
xref: RelationshipXref419
controller: Complex151

Catalysis224
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction253
control type: ACTIVATION
xref: RelationshipXref416
xref: RelationshipXref417
controller: Complex150

Catalysis223
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction252
control type: ACTIVATION
xref: RelationshipXref396
xref: RelationshipXref397
controller: Complex142

Catalysis226
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction255
control type: ACTIVATION
xref: RelationshipXref425
xref: RelationshipXref424
controller: Complex154

Catalysis225
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction254
control type: ACTIVATION
xref: RelationshipXref422
xref: RelationshipXref423
controller: Complex153

UnificationXref3560
type: UnificationXref
id: REACT_10257
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10257.1

UnificationXref3561
type: UnificationXref
id: CHEBI:16891
db: ChEBI

UnificationXref3564
type: UnificationXref
id: CHEBI:17497
db: ChEBI

UnificationXref3565
type: UnificationXref
id: 389822
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389822

UnificationXref3562
type: UnificationXref
id: 389678
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389678

UnificationXref3563
type: UnificationXref
id: REACT_17634
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17634.1

UnificationXref3568
type: UnificationXref
id: REACT_17375
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17375.1

UnificationXref3569
type: UnificationXref
id: P37666
db: UniProt

UniProt:P18956
type: ProteinReference
xref: UnificationXref2327
organism: BioSource1

UnificationXref3566
type: UnificationXref
id: REACT_17366
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17366.1

UnificationXref3567
type: UnificationXref
id: 389556
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389556

Catalysis219
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction248
control type: ACTIVATION
xref: RelationshipXref414
xref: RelationshipXref413
controller: Complex149

Catalysis218
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction247
control type: ACTIVATION
xref: RelationshipXref412
xref: RelationshipXref411
controller: Complex148

Catalysis217
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction246
control type: ACTIVATION
xref: RelationshipXref410
xref: RelationshipXref409
controller: Complex147

Catalysis216
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction245
control type: ACTIVATION
xref: RelationshipXref407
xref: RelationshipXref408
controller: Complex147

Catalysis215
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction244
control type: ACTIVATION
xref: RelationshipXref406
xref: RelationshipXref405
controller: Complex146

Catalysis214
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction243
control type: ACTIVATION
xref: RelationshipXref401
xref: RelationshipXref402
controller: Complex144

UniProt:P07650
type: ProteinReference
xref: UnificationXref2970
organism: BioSource1

Catalysis213
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction242
control type: ACTIVATION
xref: RelationshipXref400
xref: RelationshipXref310
controller: Complex108

Catalysis212
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction241
control type: ACTIVATION
xref: RelationshipXref399
xref: RelationshipXref398
controller: Complex143

Catalysis211
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction240
control type: ACTIVATION
xref: RelationshipXref388
xref: RelationshipXref387
controller: Complex136

http://identifiers.org/pubmed/2018971
type: PublicationXref
id: 2018971
author: Charo, IF
author: Scarborough, RM
author: Phillips, DR
db: Pubmed
title: GPIIb-IIIa: the responsive integrin
source: Cell 65:359-62
year: 1991

Catalysis210
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction239
control type: ACTIVATION
xref: RelationshipXref388
xref: RelationshipXref387
controller: Complex136

http://identifiers.org/pubmed/19574955
type: PublicationXref
id: 19574955
author: Beitz, E
author: Wu, B
author: Alsterfjord, M
author: Zeuthen, T
author: Steinbronn, C
db: Pubmed
title: Concerted action of two cation filters in the aquaporin water channel
source: EMBO J 28:2188-94
year: 2009

http://identifiers.org/pubmed/5940
type: PublicationXref
id: 5940
author: Povey, S
author: Wilson, Jr, DE
author: Harris, H
db: Pubmed
title: Adenylate kinases in man: evidence for a third locus
source: Ann Hum Genet 39:305-313
year: 1976

ADP [ChEBI:16761]
type: SmallMoleculeReference
name: ADP
name: Adenosine 5'-diphosphate
xref: UnificationXref361

UnificationXref3570
type: UnificationXref
id: 4232477
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232477

UnificationXref3571
type: UnificationXref
id: 4232479
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232479

UnificationXref3572
type: UnificationXref
id: REACT_104969
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104969.9

UniProt:P0AEA5
type: ProteinReference
xref: UnificationXref3715
organism: BioSource1

UnificationXref3573
type: UnificationXref
id: 389864
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389864

UnificationXref3574
type: UnificationXref
id: REACT_17855
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17855.2

UnificationXref3575
type: UnificationXref
id: P33232
db: UniProt

1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
type: SmallMoleculeReference
name: 5'-Phosphoribosyl-5-amino-4-imidazolecarboxylate [ChEBI:28413]
name: 5'-Phosphoribosyl-4-carboxy-5-aminoimidazole
name: 1-(5'-Phosphoribosyl)-5-amino-4-carboxyimidazole
name: CAIR
name: 1-(5'-Phosphoribosyl)-4-carboxy-5-aminoimidazole
name: 5'-Phosphoribosyl-5-amino-4-imidazolecarboxylate
name: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxylate
xref: UnificationXref2704

UnificationXref3576
type: UnificationXref
id: 4232482
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232482

UnificationXref3577
type: UnificationXref
id: 4232483
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232483

UnificationXref3578
type: UnificationXref
id: 4232484
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232484

UnificationXref3579
type: UnificationXref
id: 4232486
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232486

Catalysis209
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction238
control type: ACTIVATION
xref: RelationshipXref396
xref: RelationshipXref397
controller: Complex142

Catalysis206
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction235
control type: ACTIVATION
xref: RelationshipXref390
xref: RelationshipXref389
controller: Complex137

Catalysis205
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction234
control type: ACTIVATION
xref: RelationshipXref388
xref: RelationshipXref387
controller: Complex136

Catalysis208
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction237
control type: ACTIVATION
xref: RelationshipXref394
xref: RelationshipXref393
controller: Complex139

Catalysis207
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction236
control type: ACTIVATION
xref: RelationshipXref391
xref: RelationshipXref392
controller: Complex138

Catalysis202
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction231
control type: ACTIVATION
xref: RelationshipXref385
xref: RelationshipXref384
controller: Note: the coordinates are copied over from Homo sapiens.

http://identifiers.org/pubmed/21944752
type: PublicationXref
id: 21944752
author: Pierrel, F
author: Lill, R
author: Webert, H
author: Mühlenhoff, U
author: Fontecave, M
author: Ozeir, M
db: Pubmed
title: Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency
source: Chem Biol 18:1134-42
year: 2011

Catalysis201
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction230
control type: ACTIVATION
xref: RelationshipXref382
xref: RelationshipXref381
controller: Complex130

Catalysis204
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction233
control type: ACTIVATION
xref: RelationshipXref388
xref: RelationshipXref387
controller: Complex136

Catalysis203
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction232
control type: ACTIVATION
xref: RelationshipXref386
xref: RelationshipXref384
controller: Complex135

Catalysis200
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction229
control type: ACTIVATION
xref: RelationshipXref380
xref: RelationshipXref379
controller: Note: the coordinates are copied over from Homo sapiens.

UnificationXref3503
type: UnificationXref
id: 4231547
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231547

UnificationXref1282
type: UnificationXref
id: REACT_141567
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141567.5

UnificationXref3502
type: UnificationXref
id: 4231546
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231546

UnificationXref1281
type: UnificationXref
id: 4232936
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232936

UnificationXref3501
type: UnificationXref
id: P0A6E4
db: UniProt

UnificationXref1284
type: UnificationXref
id: REACT_134683
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134683.5

UnificationXref3500
type: UnificationXref
id: REACT_5577
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5577.1

UnificationXref1283
type: UnificationXref
id: 4233492
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233492

http://identifiers.org/pubmed/14592814
type: PublicationXref
id: 14592814
author: Marples, D
author: Mobasheri, A
db: Pubmed
title: Expression of the AQP-1 water channel in normal human tissues: a semiquantitative study using tissue microarray technology
source: Am J Physiol Cell Physiol 286:C529-37
year: 2004

UnificationXref1280
type: UnificationXref
id: 4232930
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232930

UnificationXref1289
type: UnificationXref
id: 4231198
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231198

1D-chiro-inositol
type: SmallMoleculeReference
name: ChEBI:27372 1D-chiro-inositol
xref: UnificationXref507

UnificationXref1286
type: UnificationXref
id: REACT_117033
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117033.1

http://identifiers.org/pubmed/12084581
type: PublicationXref
id: 12084581
author: Imai, M
author: Morinaga, T
author: Ishibashi, K
author: Sasaki, S
author: Kuwahara, M
db: Pubmed
title: Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin
source: Biochim Biophys Acta 1576:335-40
year: 2002

UnificationXref1285
type: UnificationXref
id: 1605715
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1605715

UnificationXref1288
type: UnificationXref
id: REACT_122218
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122218.1

UnificationXref1287
type: UnificationXref
id: 2160894
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2160894

UnificationXref261
type: UnificationXref
id: 4233381
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233381

UnificationXref260
type: UnificationXref
id: REACT_110861
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_110861.9

UnificationXref263
type: UnificationXref
id: GO:0005654
db: GENE ONTOLOGY

UnificationXref262
type: UnificationXref
id: REACT_104029
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104029.9

UnificationXref265
type: UnificationXref
id: 110242
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110242

UnificationXref264
type: UnificationXref
id: CHEBI:44605
db: ChEBI

UnificationXref267
type: UnificationXref
id: 4230329
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230329

UnificationXref266
type: UnificationXref
id: REACT_4681
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4681.2

UnificationXref3508
type: UnificationXref
id: REACT_5412
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5412.3

UnificationXref269
type: UnificationXref
id: 4232090
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232090

UnificationXref3509
type: UnificationXref
id: CHEBI:16467
db: ChEBI

UnificationXref268
type: UnificationXref
id: 4232088
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232088

UnificationXref3506
type: UnificationXref
id: CHEBI:37154
db: ChEBI

UnificationXref3507
type: UnificationXref
id: 29586
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29586

UnificationXref3504
type: UnificationXref
id: 4231549
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231549

http://identifiers.org/pubmed/10524214
type: PublicationXref
id: 10524214
author: Cregeen, DP
author: Rumsby, G
db: Pubmed
title: Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase
source: Biochim Biophys Acta 1446:383-8
year: 1999

UnificationXref3505
type: UnificationXref
id: REACT_98815
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98815.9

UnificationXref3512
type: UnificationXref
id: P11447
db: UniProt

UnificationXref1295
type: UnificationXref
id: 4233155
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233155

UnificationXref3511
type: UnificationXref
id: REACT_2911
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2911.2

UnificationXref1294
type: UnificationXref
id: 4233154
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233154

UnificationXref3514
type: UnificationXref
id: 4231541
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231541

UnificationXref1293
type: UnificationXref
id: P05804
db: UniProt

UnificationXref3513
type: UnificationXref
id: 4231540
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231540

UnificationXref1292
type: UnificationXref
id: REACT_122801
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122801.1

UnificationXref1291
type: UnificationXref
id: 1678868
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1678868

UnificationXref1290
type: UnificationXref
id: CHEBI:4178
db: ChEBI

UnificationXref3510
type: UnificationXref
id: 29468
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29468

UnificationXref1299
type: UnificationXref
id: 2162224
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162224

UnificationXref1298
type: UnificationXref
id: CHEBI:64024
db: ChEBI

UnificationXref1297
type: UnificationXref
id: REACT_139685
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139685.5

UnificationXref1296
type: UnificationXref
id: 4233260
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233260

UnificationXref272
type: UnificationXref
id: REACT_83025
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83025.9

http://identifiers.org/pubmed/5666113
type: PublicationXref
id: 5666113
author: Luzzatto, L
author: Afolayan, A
db: Pubmed
title: Enzymic properties of different types of human erythrocyte glucose-6-phosphate dehydrogenase, with characterization of two new genetic variants
source: J Clin Invest 47:1833-42
year: 1968

UnificationXref271
type: UnificationXref
id: 4233383
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233383

http://identifiers.org/pubmed/17186029
type: PublicationXref
id: 17186029
author: Mariathasan, S
author: Monack, DM
db: Pubmed
title: Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
source: Nat Rev Immunol 7:31-40
year: 2007

UnificationXref270
type: UnificationXref
id: REACT_34400
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34400.10

UnificationXref276
type: UnificationXref
id: 4232051
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232051

UnificationXref275
type: UnificationXref
id: P0A9H1
db: UniProt

UnificationXref274
type: UnificationXref
id: REACT_102879
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102879.9

http://identifiers.org/pubmed/18165232
type: PublicationXref
id: 18165232
author: Kobayashi, T
author: Matsui, H
author: Tamura, S
author: Tomishige, N
author: Saito, S
author: Kumagai, K
author: Kawano, M
author: Echigo, S
author: Hanada, K
db: Pubmed
title: Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes
source: J Biol Chem 283:6584-93
year: 2008

UnificationXref273
type: UnificationXref
id: 4233382
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233382

UnificationXref3519
type: UnificationXref
id: CHEBI:18020
db: ChEBI

UnificationXref279
type: UnificationXref
id: 4232066
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232066

UnificationXref278
type: UnificationXref
id: 4232065
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232065

UnificationXref277
type: UnificationXref
id: 4232064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232064

UnificationXref3515
type: UnificationXref
id: 4231543
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231543

UnificationXref3516
type: UnificationXref
id: REACT_114884
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114884.8

UnificationXref3517
type: UnificationXref
id: 4233318
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233318

UnificationXref3518
type: UnificationXref
id: REACT_90218
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90218.9

UnificationXref3521
type: UnificationXref
id: REACT_4362
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4362.2

http://identifiers.org/pubmed/8380692
type: PublicationXref
id: 8380692
author: Itakura, M
author: Kudo, E
author: Yoshimoto, K
author: Mizusawa, N
author: Holmes, EW
author: Ii, S
author: Oka, J
author: Iwahana, H
db: Pubmed
title: Molecular cloning of human amidophosphoribosyltransferase
source: Biochem Biophys Res Commun 190:192-200
year: 1993

UnificationXref3520
type: UnificationXref
id: 31311
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31311

15-Keto-PGF2a
type: SmallMoleculeReference
name: 15-Keto-prostaglandin F2alpha
name: 15-Keto-prostaglandin F2alpha [ChEBI:760]
name: 15-Keto-prostaglandin F2a
name: 15-Keto-PGF2alpha
xref: UnificationXref2277

UnificationXref3525
type: UnificationXref
id: P17445
db: UniProt

UnificationXref3524
type: UnificationXref
id: REACT_4905
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4905.2

UnificationXref3523
type: UnificationXref
id: 31369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31369

UnificationXref3522
type: UnificationXref
id: CHEBI:16244
db: ChEBI

UnificationXref290
type: UnificationXref
id: P0AB83
db: UniProt

http://identifiers.org/pubmed/11331907
type: PublicationXref
id: 11331907
author: Irvine, RF
author: Schell, MJ
db: Pubmed
title: Back in the water: the return of the inositol phosphates
source: Nat Rev Mol Cell Biol 2:327-38
year: 2001

UnificationXref285
type: UnificationXref
id: 4232056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232056

UnificationXref284
type: UnificationXref
id: REACT_102526
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102526.9

UnificationXref287
type: UnificationXref
id: 4232058
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232058

UnificationXref286
type: UnificationXref
id: 4232057
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232057

UnificationXref281
type: UnificationXref
id: 4232052
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232052

UnificationXref280
type: UnificationXref
id: REACT_93666
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93666.9

UnificationXref283
type: UnificationXref
id: 4232055
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232055

UnificationXref282
type: UnificationXref
id: 4232053
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232053

UnificationXref3528
type: UnificationXref
id: 4231667
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231667

UnificationXref3529
type: UnificationXref
id: REACT_102594
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102594.9

UnificationXref3526
type: UnificationXref
id: 4231664
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231664

http://identifiers.org/pubmed/16825786
type: PublicationXref
id: 16825786
author: Debut, AJ
author: Saier MH, Jr
author: Mansour, NM
author: Dumay, QC
db: Pubmed
title: The copper transporter (Ctr) family of Cu+ uptake systems
source: J Mol Microbiol Biotechnol 11:10-9
year: 2006

UnificationXref3527
type: UnificationXref
id: 4231665
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231665

UnificationXref289
type: UnificationXref
id: 4230316
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230316

UnificationXref288
type: UnificationXref
id: REACT_78317
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78317.9

UnificationXref3530
type: UnificationXref
id: 4233338
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233338

UnificationXref3532
type: UnificationXref
id: CHEBI:15625
db: ChEBI

UnificationXref3531
type: UnificationXref
id: REACT_33473
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33473.10

UnificationXref3534
type: UnificationXref
id: REACT_15233
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15233.2

UnificationXref3533
type: UnificationXref
id: 353113
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=353113

UnificationXref3536
type: UnificationXref
id: 29610
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29610

UnificationXref3535
type: UnificationXref
id: CHEBI:17148
db: ChEBI

UnificationXref298
type: UnificationXref
id: REACT_90229
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90229.9

UnificationXref297
type: UnificationXref
id: 4232070
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232070

UnificationXref296
type: UnificationXref
id: 4232069
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232069

UnificationXref295
type: UnificationXref
id: 4230322
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230322

UnificationXref294
type: UnificationXref
id: REACT_83282
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83282.9

UnificationXref293
type: UnificationXref
id: 4232063
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232063

UnificationXref292
type: UnificationXref
id: 4232062
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232062

UnificationXref291
type: UnificationXref
id: 4232061
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232061

UnificationXref3537
type: UnificationXref
id: REACT_2757
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2757.1

UnificationXref3538
type: UnificationXref
id: CHEBI:16610
db: ChEBI

UnificationXref3539
type: UnificationXref
id: 204635
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=204635

UnificationXref299
type: UnificationXref
id: 4230325
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230325

http://identifiers.org/pubmed/21554866
type: PublicationXref
id: 21554866
author: Cox, Brian J
author: Biechele, Steffen
author: Rossant, Janet
db: Pubmed
title: Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos
source: Dev. Biol. 355:275-85
year: 2011

L-Tryptophan [ChEBI:16828]
type: SmallMoleculeReference
name: (S)-alpha-amino-beta-(3-indolyl)-propionic acid
name: L-Tryptophan
xref: UnificationXref954

http://identifiers.org/pubmed/20301507
type: PublicationXref
id: 20301507
author: Stephens, K
author: Sparks, SE
author: Bird, TC
author: Pagon, RA
author: Dolan, CR
author: Krasnewich, DM
db: Pubmed
title: Congenital Disorders of Glycosylation Overview
year: 1993

Catalysis189
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction216
control type: ACTIVATION
xref: RelationshipXref355
xref: RelationshipXref356
controller: P0ADE6

Catalysis188
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction215
control type: ACTIVATION
xref: RelationshipXref355
xref: RelationshipXref356
controller: P0ADE6

Catalysis187
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction214
control type: ACTIVATION
xref: RelationshipXref354
xref: RelationshipXref353
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis186
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction213
control type: ACTIVATION
xref: RelationshipXref351
xref: RelationshipXref352
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis195
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction224
control type: ACTIVATION
xref: RelationshipXref370
xref: RelationshipXref369
controller: Complex127

Catalysis196
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction225
control type: ACTIVATION
xref: RelationshipXref372
xref: RelationshipXref371
controller: Complex127

Catalysis193
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction222
control type: ACTIVATION
xref: RelationshipXref365
xref: RelationshipXref366
controller: FGAM synthase

Catalysis194
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction223
control type: ACTIVATION
xref: RelationshipXref368
xref: RelationshipXref367
controller: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Catalysis191
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction220
control type: ACTIVATION
xref: RelationshipXref361
xref: RelationshipXref362
controller: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Catalysis192
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction221
control type: ACTIVATION
xref: RelationshipXref364
xref: RelationshipXref363
controller: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Catalysis190
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction219
control type: ACTIVATION
xref: RelationshipXref359
xref: RelationshipXref360
controller: Complex125

UniProt:P0ADE6
type: ProteinReference
xref: UnificationXref2628
organism: BioSource1

UniProt:P76341
type: ProteinReference
xref: UnificationXref1276
organism: BioSource1

Catalysis198
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction227
control type: ACTIVATION
xref: RelationshipXref375
xref: RelationshipXref376
controller: Complex128

Catalysis197
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction226
control type: ACTIVATION
xref: RelationshipXref374
xref: RelationshipXref373
controller: Complex128

Catalysis199
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction228
control type: ACTIVATION
xref: RelationshipXref377
xref: RelationshipXref378
controller: Complex129

http://identifiers.org/pubmed/17143292
type: PublicationXref
id: 17143292
author: Kimelman, D
author: Xu, W
db: Pubmed
title: beta-catenin destruction complex: insights and questions from a structural perspective
source: Oncogene 25:7482-91
year: 2006

Methanamine
type: SmallMoleculeReference
name: Methylamine [ChEBI:6864]
name: Methylamine
xref: UnificationXref2781

http://identifiers.org/pubmed/13032008
type: PublicationXref
id: 13032008
author: Lipmann, F
db: Pubmed
title: On chemistry and function of coenzyme A
source: Bacteriol Rev 17:1-16
year: 1953

alvespimycin [ChEBI:65324]
type: SmallMoleculeReference
name: alvespimycin
xref: UnificationXref1255

RelationshipXref579
type: RelationshipXref
id: GO:0035379
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/8394361
type: PublicationXref
id: 8394361
author: Kasama, T
author: Shimizu, T
author: Taketani, Y
author: Izumi, T
author: Takahashi, T
author: Kobayashi, Y
author: Yokomizo, T
author: Sato, F
db: Pubmed
title: Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase
source: J Biol Chem 268:18128-35
year: 1993

RelationshipXref577
type: RelationshipXref
id: GO:0006750
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite100
type: SequenceSite
position status: EQUAL
sequence position: 669

RelationshipXref578
type: RelationshipXref
id: GO:1901687
db: GENE ONTOLOGY
relationship type: MI:0359

DNA Repair
type: Pathway
data source: Provenance1
pathway component: Base Excision Repair
evidence: Evidence52
xref: RelationshipXref29
xref: UnificationXref350
xref: UnificationXref351
pathway order: PathwayStep46
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref575
type: RelationshipXref
id: 4232182
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232182

SequenceSite102
type: SequenceSite
position status: EQUAL
sequence position: 725

RelationshipXref576
type: RelationshipXref
id: 4232980
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232980

SequenceSite101
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref573
type: RelationshipXref
id: GO:0050427
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite104
type: SequenceSite
position status: EQUAL
sequence position: 577

RelationshipXref574
type: RelationshipXref
id: GO:0004060
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite103
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref571
type: RelationshipXref
id: GO:0006065
db: GENE ONTOLOGY
relationship type: MI:0359

Catalysis167
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction193
control type: ACTIVATION
xref: RelationshipXref311
xref: RelationshipXref310
controller: PhysicalEntity28

SequenceSite106
type: SequenceSite
position status: EQUAL
sequence position: 645

Platelet degranulation
type: Pathway
data source: Provenance1
pathway component: Release of platelet cytosolic components
evidence: Evidence123
xref: RelationshipXref88
xref: UnificationXref799
xref: UnificationXref800
pathway order: PathwayStep114
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref572
type: RelationshipXref
id: GO:0052695
db: GENE ONTOLOGY
relationship type: MI:0359

Catalysis166
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction192
control type: ACTIVATION
xref: RelationshipXref308
xref: RelationshipXref307
controller: Complex105

SequenceSite105
type: SequenceSite
position status: EQUAL
sequence position: 1

Catalysis165
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction191
control type: ACTIVATION
xref: RelationshipXref305
xref: RelationshipXref306
controller: Note: the coordinates are copied over from Homo sapiens.

SequenceSite108
type: SequenceSite
position status: EQUAL
sequence position: 639

RelationshipXref570
type: RelationshipXref
id: 4232171
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232171

Catalysis164
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction190
control type: ACTIVATION
xref: RelationshipXref304
xref: RelationshipXref303
controller: Complex104

SequenceSite107
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite109
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:P76373
type: ProteinReference
xref: UnificationXref3741
organism: BioSource1

Catalysis169
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction195
control type: ACTIVATION
xref: RelationshipXref311
xref: RelationshipXref310
controller: PhysicalEntity28

Catalysis168
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction194
control type: ACTIVATION
xref: RelationshipXref313
xref: RelationshipXref310
controller: PhysicalEntity29

Catalysis170
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction196
control type: ACTIVATION
xref: RelationshipXref311
xref: RelationshipXref310
controller: PhysicalEntity28

Catalysis173
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction200
control type: ACTIVATION
xref: RelationshipXref318
xref: RelationshipXref319
controller: Complex111

Catalysis174
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction201
control type: ACTIVATION
xref: RelationshipXref320
xref: RelationshipXref321
controller: Complex112

UniProt:P0ADG4
type: ProteinReference
xref: UnificationXref1760
organism: BioSource1

Catalysis171
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction197
control type: ACTIVATION
xref: RelationshipXref298
xref: RelationshipXref299
controller: Complex103

Catalysis172
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction198
control type: ACTIVATION
xref: RelationshipXref314
xref: RelationshipXref315
controller: Note: the coordinates are copied over from Homo sapiens.

UniProt:P0ADG7
type: ProteinReference
xref: UnificationXref2733
organism: BioSource1

http://identifiers.org/pubmed/9486145
type: PublicationXref
id: 9486145
author: Romero, MF
author: Nakhoul, NL
author: Boron, WF
author: Davis, BA
db: Pubmed
title: Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes
source: Am J Physiol 274:C543-8
year: 1998

SequenceSite111
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite110
type: SequenceSite
position status: EQUAL
sequence position: 690

RelationshipXref584
type: RelationshipXref
id: GO:0017144
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite115
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref585
type: RelationshipXref
id: GO:0044281
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite114
type: SequenceSite
position status: EQUAL
sequence position: 679

SequenceSite113
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite112
type: SequenceSite
position status: EQUAL
sequence position: 599

RelationshipXref580
type: RelationshipXref
id: 4232974
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232974

Catalysis176
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction203
control type: ACTIVATION
xref: RelationshipXref326
xref: RelationshipXref327
controller: Complex113

SequenceSite119
type: SequenceSite
position status: EQUAL
sequence position: 1

Dehydroepiandrosterone sulfate
type: SmallMoleculeReference
name: 3beta-Hydroxyandrost-5-en-17-one 3-sulfate
name: Dehydroepiandrosterone sulfate [ChEBI:16814]
xref: UnificationXref2431

RelationshipXref581
type: RelationshipXref
id: GO:0015701
db: GENE ONTOLOGY
relationship type: MI:0359

Catalysis175
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction202
control type: ACTIVATION
xref: RelationshipXref325
xref: RelationshipXref324
controller: Para-hydroxybenzoate--polyprenyltransferase, mitochondrial

SequenceSite118
type: SequenceSite
position status: EQUAL
sequence position: 652

RelationshipXref582
type: RelationshipXref
id: GO:0019201
db: GENE ONTOLOGY
relationship type: MI:0355

Catalysis178
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction205
control type: ACTIVATION
xref: RelationshipXref330
xref: RelationshipXref331
controller: Note: the coordinates are copied over from Homo sapiens.

SequenceSite117
type: SequenceSite
position status: EQUAL
sequence position: 1

Activation of Genes by ATF4
type: Pathway
data source: Provenance1
pathway component: Expression of Asparagine Synthetase
evidence: Evidence164
xref: UnificationXref1135
xref: UnificationXref1136
pathway order: PathwayStep155
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref583
type: RelationshipXref
id: 4233227
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233227

Catalysis177
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction204
control type: ACTIVATION
xref: RelationshipXref329
xref: RelationshipXref328
controller: COQ3_HUMAN

SequenceSite116
type: SequenceSite
position status: EQUAL
sequence position: 679

Catalysis179
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction206
control type: ACTIVATION
xref: RelationshipXref333
xref: RelationshipXref332
controller: COQ3_HUMAN

Catalysis180
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction207
control type: ACTIVATION
xref: RelationshipXref339
xref: RelationshipXref338
controller: Complex114

Catalysis181
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction208
control type: ACTIVATION
xref: RelationshipXref340
xref: RelationshipXref341
controller: Complex116

Type II Na+/Pi cotransporters
type: Pathway
data source: Provenance1
pathway component: Electroneutral Na+/Pi cotransport
pathway component: Electrogenic Na+/Pi cotransport
evidence: Evidence63
xref: UnificationXref428
xref: UnificationXref429
pathway order: PathwayStep56
pathway order: PathwayStep55
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Catalysis182
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction209
control type: ACTIVATION
xref: RelationshipXref345
xref: RelationshipXref344
controller: Complex117

Catalysis183
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction210
control type: ACTIVATION
xref: RelationshipXref347
xref: RelationshipXref346
controller: Complex123

Catalysis184
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction211
control type: ACTIVATION
xref: RelationshipXref349
xref: RelationshipXref348
controller: Complex124

Catalysis185
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction212
control type: ACTIVATION
xref: RelationshipXref188
xref: RelationshipXref187
controller: malate dehydrogenase 2 dimer (name copied from entity in Homo sapiens)

Sulfur amino acid metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 136193.5
pathway component: Methionine salvage pathway
pathway component: REACT 137414.5
evidence: Evidence551
xref: UnificationXref3626
xref: UnificationXref3625
xref: RelationshipXref548
pathway order: PathwayStep526
pathway order: PathwayStep533
pathway order: PathwayStep538
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Catalysis148
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction174
control type: ACTIVATION
xref: RelationshipXref262
xref: RelationshipXref263
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis149
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction175
control type: ACTIVATION
xref: RelationshipXref266
xref: RelationshipXref265
controller: ABCD1 homodimer (name copied from entity in Homo sapiens)

Catalysis146
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction172
control type: ACTIVATION
xref: RelationshipXref256
xref: RelationshipXref257
controller: Homologues of GPD2

Catalysis147
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction173
control type: ACTIVATION
xref: RelationshipXref260
xref: RelationshipXref259
controller: HACL1 tetramer (name copied from entity in Homo sapiens)

Catalysis144
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction170
control type: ACTIVATION
xref: RelationshipXref250
xref: RelationshipXref249
controller: BDH1 tetramer (name copied from entity in Homo sapiens)

Catalysis145
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction171
control type: ACTIVATION
xref: RelationshipXref253
xref: RelationshipXref252
controller: OXCT1 dimer (name copied from entity in Homo sapiens)

Catalysis142
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction168
control type: ACTIVATION
xref: RelationshipXref246
xref: RelationshipXref247
controller: 2xMMAA:2xMUT:AdoCbl (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/8089153
type: PublicationXref
id: 8089153
author: Hirst, M
author: Lou, L
author: Nakamura, J
author: Haliday, E
db: Pubmed
title: Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA
source: J Biol Chem 269:23830-23837
year: 1994

http://identifiers.org/pubmed/22658984
type: PublicationXref
id: 22658984
author: Korenbrot, Juan I
db: Pubmed
title: Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models
source: Prog Retin Eye Res 31:442-66
year: 2012

Catalysis143
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction169
control type: ACTIVATION
xref: RelationshipXref250
xref: RelationshipXref249
controller: BDH1 tetramer (name copied from entity in Homo sapiens)

Catalysis152
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction178
control type: ACTIVATION
xref: RelationshipXref273
xref: RelationshipXref272
controller: Complex100

6-Phospho-D-gluconate [ChEBI:16863]
type: SmallMoleculeReference
name: 6-Phospho-D-gluconate
xref: UnificationXref1685

Catalysis151
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction177
control type: ACTIVATION
xref: RelationshipXref269
xref: RelationshipXref270
controller: GNPAT:AGPS complex (name copied from entity in Homo sapiens)

Catalysis150
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction176
control type: ACTIVATION
xref: RelationshipXref267
xref: RelationshipXref268
controller: GNPAT:AGPS complex (name copied from entity in Homo sapiens)

gamma-Aminobutyric acid
type: SmallMoleculeReference
name: (4-Aminobutyl)guanidine
name: 4-Aminobutyric acid
name: 4-Aminobutyrate
name: 4-Aminobutanoate [ChEBI:16865]
name: 4-Aminobutylate
name: 4-Aminobutanoic acid
name: 4-Aminobutanoate
xref: UnificationXref1186

Catalysis157
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction183
control type: ACTIVATION
xref: RelationshipXref286
xref: RelationshipXref287
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis158
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction184
control type: ACTIVATION
xref: RelationshipXref289
xref: RelationshipXref290
controller: Complex102

Catalysis159
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction185
control type: ACTIVATION
xref: RelationshipXref30
xref: RelationshipXref294
controller: Protein55

Catalysis153
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction179
control type: ACTIVATION
xref: RelationshipXref276
xref: RelationshipXref275
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis154
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction180
control type: ACTIVATION
xref: RelationshipXref280
xref: RelationshipXref267
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis155
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction181
control type: ACTIVATION
xref: RelationshipXref231
xref: RelationshipXref281
controller: GPAM/GPAT2

Catalysis156
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction182
control type: ACTIVATION
xref: RelationshipXref283
xref: RelationshipXref284
controller: Complex101

Catalysis161
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction187
control type: ACTIVATION
xref: RelationshipXref30
xref: RelationshipXref294
controller: Protein55

Catalysis160
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction186
control type: ACTIVATION
xref: RelationshipXref262
xref: RelationshipXref263
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis163
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction189
control type: ACTIVATION
xref: RelationshipXref301
xref: RelationshipXref300
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis162
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction188
control type: ACTIVATION
xref: RelationshipXref298
xref: RelationshipXref299
controller: Complex103

PublicationXref937
type: PublicationXref
id: 0079130356
author: Webster, DR
author: Becroft, DM
author: van Kuilenberg, AB
author: van Gennip, AH
db: ISBN
title: Hereditary orotic aciduria and other disorders of pyrimidine metabolism
source: The Metabolic and Molecular Bases of Inherited Disease, 8th ed (Book): 2663-2704
year: 2001

Catalysis122
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction145
control type: ACTIVATION
xref: RelationshipXref225
xref: RelationshipXref226
controller: IMPA1/2

http://identifiers.org/pubmed/14729598
type: PublicationXref
id: 14729598
author: Zhou, B
author: Shao, J
author: Zhu, L
author: Yen, Y
author: Qiu, W
author: Xi, B
author: Yuan, YC
db: Pubmed
title: In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase
source: Cancer Res 64:1-6
year: 2004

Catalysis123
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction149
control type: ACTIVATION
xref: RelationshipXref229
xref: RelationshipXref230
controller: P0A6F3

Catalysis120
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction143
control type: ACTIVATION
xref: RelationshipXref221
xref: RelationshipXref222
controller: IMPA1/2

Catalysis121
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction144
control type: ACTIVATION
xref: RelationshipXref224
xref: RelationshipXref223
controller: IMPA1/2

Catalysis126
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction152
control type: ACTIVATION
xref: RelationshipXref237
xref: RelationshipXref236
controller: Trifunctional Protein (name copied from entity in Homo sapiens)

Catalysis127
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction153
control type: ACTIVATION
xref: RelationshipXref239
xref: RelationshipXref238
controller: Trifunctional Protein (name copied from entity in Homo sapiens)

Catalysis124
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction150
control type: ACTIVATION
xref: RelationshipXref231
xref: RelationshipXref232
controller: GPAM or GPAT2

Catalysis125
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction151
control type: ACTIVATION
xref: RelationshipXref234
xref: RelationshipXref233
controller: LPAAT

Pyruvate
type: SmallMoleculeReference
name: Pyruvic acid
name: Pyroracemic acid
name: 2-Oxopropanoate
name: 2-Oxopropanoic acid
name: Pyruvate [ChEBI:32816]
xref: UnificationXref1524

Catalysis128
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction154
control type: ACTIVATION
xref: RelationshipXref240
xref: RelationshipXref241
controller: Trifunctional Protein (name copied from entity in Homo sapiens)

Catalysis129
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction155
control type: ACTIVATION
xref: RelationshipXref237
xref: RelationshipXref236
controller: Trifunctional Protein (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/16720382
type: PublicationXref
id: 16720382
author: Maguire, ME
db: Pubmed
title: Magnesium transporters: properties, regulation and structure
source: Front Biosci 11:3149-63
year: 2006

Catalysis130
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction156
control type: ACTIVATION
xref: RelationshipXref239
xref: RelationshipXref238
controller: Trifunctional Protein (name copied from entity in Homo sapiens)

Phosphopantetheine
type: SmallMoleculeReference
name: Pantetheine 4'-phosphate [ChEBI:16858]
name: 4'-Phosphopantetheine
name: Pantetheine 4'-phosphate
xref: UnificationXref3161

Catalysis131
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction157
control type: ACTIVATION
xref: RelationshipXref240
xref: RelationshipXref241
controller: Trifunctional Protein (name copied from entity in Homo sapiens)

L-Threonine
type: SmallMoleculeReference
name: 2-Amino-3-hydroxybutyric acid
name: L-Threonine [ChEBI:6308]
xref: UnificationXref126

Catalysis132
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction158
control type: ACTIVATION
xref: RelationshipXref243
xref: RelationshipXref236
controller: ECHS1 hexamer (name copied from entity in Homo sapiens)

gamma-L-Glutamyl-L-cysteinyl-glycine
type: SmallMoleculeReference
name: 5-L-Glutamyl-L-cysteinylglycine
name: N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine
name: Reduced glutathione
name: Glutathione
name: GSH
name: Glutathione [ChEBI:16856]
xref: UnificationXref2342

Catalysis133
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction159
control type: ACTIVATION
xref: RelationshipXref240
xref: RelationshipXref241
controller: Trifunctional Protein (name copied from entity in Homo sapiens)

Catalysis134
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction160
control type: ACTIVATION
xref: RelationshipXref243
xref: RelationshipXref236
controller: ECHS1 hexamer (name copied from entity in Homo sapiens)

Catalysis135
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction161
control type: ACTIVATION
xref: RelationshipXref240
xref: RelationshipXref241
controller: Trifunctional Protein (name copied from entity in Homo sapiens)

Catalysis136
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction162
control type: ACTIVATION
xref: RelationshipXref243
xref: RelationshipXref236
controller: ECHS1 hexamer (name copied from entity in Homo sapiens)

Catalysis137
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction163
control type: ACTIVATION
xref: RelationshipXref240
xref: RelationshipXref241
controller: Trifunctional Protein (name copied from entity in Homo sapiens)

Catalysis138
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction164
control type: ACTIVATION
xref: RelationshipXref243
xref: RelationshipXref236
controller: ECHS1 hexamer (name copied from entity in Homo sapiens)

Catalysis139
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction165
control type: ACTIVATION
xref: RelationshipXref240
xref: RelationshipXref241
controller: Trifunctional Protein (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/16807922
type: PublicationXref
id: 16807922
author: Hu, WS
author: Lee, MM
author: Hossler, P
author: Goh, LT
db: Pubmed
title: GlycoVis: visualizing glycan distribution in the protein N-glycosylation pathway in mammalian cells
source: Biotechnol Bioeng 95:946-60
year: 2006

http://identifiers.org/pubmed/8656081
type: PublicationXref
id: 8656081
author: Hurt, E
author: Moore, SA
author: Yoder, E
author: Spector, AA
author: Sprecher, H
db: Pubmed
title: Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid
source: J Lipid Res 36:2433-43
year: 1995

http://identifiers.org/pubmed/19261609
type: PublicationXref
id: 19261609
author: Vitvitsky, V
author: Singh, S
author: Banerjee, R
author: Zhu, W
author: Chiku, T
author: Padovani, D
db: Pubmed
title: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia
source: J Biol Chem 284:11601-12
year: 2009

Synthesis of PG
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction183
evidence: Evidence348
xref: UnificationXref2207
xref: UnificationXref2206
xref: RelationshipXref288
pathway order: PathwayStep334
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/9686307
type: PublicationXref
id: 9686307
author: Teplow, DB
db: Pubmed
title: Structural and kinetic features of amyloid beta-protein fibrillogenesis
source: Amyloid 5:121-42
year: 1998

Catalysis141
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction167
control type: ACTIVATION
xref: RelationshipXref244
xref: RelationshipXref245
controller: DECR1 tetramer (name copied from entity in Homo sapiens)

Cys-Gly
type: SmallMoleculeReference
name: Cys-Gly [ChEBI:4047]
name: L-Cysteinylglycine
xref: UnificationXref3846

Catalysis140
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction166
control type: ACTIVATION
xref: RelationshipXref243
xref: RelationshipXref236
controller: ECHS1 hexamer (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/16024644
type: PublicationXref
id: 16024644
author: Shimamura, T
author: Shapiro, GI
author: Engelman, JA
author: Lowell, AM
db: Pubmed
title: Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
source: Cancer Res 65:6401-8
year: 2005

RelationshipXref516
type: RelationshipXref
id: 4231536
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231536

SequenceSite161
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref515
type: RelationshipXref
id: GO:0004585
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite162
type: SequenceSite
position status: EQUAL
sequence position: 691

RelationshipXref518
type: RelationshipXref
id: 4231548
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231548

RelationshipXref517
type: RelationshipXref
id: GO:0004055
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite160
type: SequenceSite
position status: EQUAL
sequence position: 649

RelationshipXref519
type: RelationshipXref
id: GO:0004056
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite169
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite168
type: SequenceSite
position status: EQUAL
sequence position: 658

RelationshipXref510
type: RelationshipXref
id: 4231595
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231595

SequenceSite167
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/17222166
type: PublicationXref
id: 17222166
author: Wright, EM
author: Loo, DF
author: Hirayama, BA
db: Pubmed
title: Active sugar transport in health and disease
source: J Intern Med 261:32-43
year: 2007

RelationshipXref511
type: RelationshipXref
id: GO:0006562
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite166
type: SequenceSite
position status: EQUAL
sequence position: 691

RelationshipXref512
type: RelationshipXref
id: GO:0016212
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite165
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/17222168
type: PublicationXref
id: 17222168
author: Agre, P
author: Frøkiaer, J
author: Nielsen, S
author: Kwon, TH
db: Pubmed
title: Regulation and dysregulation of aquaporins in water balance disorders
source: J Intern Med 261:53-64
year: 2007

RelationshipXref513
type: RelationshipXref
id: 4232785
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232785

SequenceSite164
type: SequenceSite
position status: EQUAL
sequence position: 691

RelationshipXref514
type: RelationshipXref
id: GO:0006569
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite163
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/7510718
type: PublicationXref
id: 7510718
author: Ishibashi, K
author: Fushimi, K
author: Saito, F
author: Inui, K
author: Nakajima, K
author: Uchida, S
author: Saito, H
author: Ikeuchi, T
author: Kuwahara, M
author: Sasaki, S
db: Pubmed
title: Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct
source: J Clin Invest 93:1250-6
year: 1994

RelationshipXref529
type: RelationshipXref
id: GO:0019509
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite170
type: SequenceSite
position status: EQUAL
sequence position: 658

RelationshipXref528
type: RelationshipXref
id: 4232976
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232976

SequenceSite171
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref527
type: RelationshipXref
id: GO:0008483
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite172
type: SequenceSite
position status: EQUAL
sequence position: 658

RelationshipXref526
type: RelationshipXref
id: 4232362
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232362

SequenceSite173
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref520
type: RelationshipXref
id: 4231542
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231542

SequenceSite179
type: SequenceSite
position status: EQUAL
sequence position: 271

RelationshipXref521
type: RelationshipXref
id: GO:0000050
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite178
type: SequenceSite
position status: EQUAL
sequence position: 1

Heme biosynthesis
type: Pathway
data source: Provenance1
pathway component: Conversion of coproporphyrinogen III to protoporphyrinogen IX
pathway component: Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I
pathway component: Four PBGs combine through deamination to form hydroxymethylbilane (HMB)
pathway component: ALAD octamer associates with Pb++, forming a catalytically inactive complex
pathway component: COX10 transforms heme to heme O
pathway component: Ferrous iron is inserted into protoporphyrin IX to form heme
pathway component: Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III
pathway component: Two molecules of ALA condense to form porphobilinogen (PBG)
evidence: Evidence561
xref: UnificationXref3720
xref: RelationshipXref562
xref: UnificationXref3719
pathway order: PathwayStep548
pathway order: PathwayStep543
pathway order: PathwayStep545
pathway order: PathwayStep541
pathway order: PathwayStep547
pathway order: PathwayStep544
pathway order: PathwayStep542
pathway order: PathwayStep546
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref524
type: RelationshipXref
id: GO:0045329
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite175
type: SequenceSite
position status: EQUAL
sequence position: 2

RelationshipXref525
type: RelationshipXref
id: GO:0004766
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite174
type: SequenceSite
position status: EQUAL
sequence position: 263

RelationshipXref522
type: RelationshipXref
id: GO:0004028
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite177
type: SequenceSite
position status: EQUAL
sequence position: 256

RelationshipXref523
type: RelationshipXref
id: 4231666
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231666

SequenceSite176
type: SequenceSite
position status: EQUAL
sequence position: 269

http://identifiers.org/pubmed/16125937
type: PublicationXref
id: 16125937
author: Ewalt, KL
author: Kim, S
author: Park, SG
db: Pubmed
title: Functional expansion of aminoacyl-tRNA synthetases and their interacting factors: new perspectives on housekeepers
source: Trends Biochem Sci 30:569-74
year: 2005

http://identifiers.org/pubmed/8621661
type: PublicationXref
id: 8621661
author: Hu, CA
author: Valle, D
author: Lin, WW
db: Pubmed
title: Cloning, characterization, and expression of cDNAs encoding human delta 1-pyrroline-5-carboxylate dehydrogenase
source: J Biol Chem 271:9795-800
year: 1996

all-trans-Retinene
type: SmallMoleculeReference
name: all-trans-Vitamin A aldehyde
name: Retinal [ChEBI:17898]
name: Retinene
name: Vitamin A aldehyde
name: Retinal
name: all-trans-Retinal
xref: UnificationXref176

PublicationXref966
type: PublicationXref
id: 0121227022
author: Noda, L
db: ISBN
title: Adenylate kinase
source: The Enzymes, 3rd ed (Book): 279-305
year: 1973

L-Tyrosine [ChEBI:17895]
type: SmallMoleculeReference
name: (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid
name: L-Tyrosine
name: (S)-3-(p-Hydroxyphenyl)alanine
xref: UnificationXref807

2-Oxoadipate
type: SmallMoleculeReference
name: 2-Oxoadipate [ChEBI:15753]
name: 2-Oxoadipic acid
xref: UnificationXref3430

http://identifiers.org/pubmed/12151341
type: PublicationXref
id: 12151341
author: Takamori, S
author: Malherbe, P
author: Jahn, R
author: Broger, C
db: Pubmed
title: Molecular cloning and functional characterization of human vesicular glutamate transporter 3
source: EMBO Rep 3:798-803
year: 2002

SequenceSite180
type: SequenceSite
position status: EQUAL
sequence position: 1

PublicationXref964
type: PublicationXref
id: 0121227022
author: Anderson, EP
db: ISBN
title: Nucleoside and nucleotide kinases
source: The Enzymes, 3rd ed (Book): 49-96
year: 1973

SequenceSite183
type: SequenceSite
position status: EQUAL
sequence position: 323

SequenceSite184
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite181
type: SequenceSite
position status: EQUAL
sequence position: 292

(S)-3-Hydroxyhexadecanoyl-CoA [ChEBI:27402]
type: SmallMoleculeReference
name: (S)-3-Hydroxyhexadecanoyl-CoA
xref: UnificationXref1839

SequenceSite182
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite188
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite187
type: SequenceSite
position status: EQUAL
sequence position: 342

SequenceSite186
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite185
type: SequenceSite
position status: EQUAL
sequence position: 265

http://identifiers.org/pubmed/165196
type: PublicationXref
id: 165196
author: Forman, JH
author: Kennedy, J
db: Pubmed
title: Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid.
source: J Biol Chem 250:4322-6
year: 1975

SequenceSite189
type: SequenceSite
position status: EQUAL
sequence position: 261

Hexadecylic acid
type: SmallMoleculeReference
name: Hexadecanoic acid
name: Palmitic acid
name: Hexadecanoate
name: Palmitate [ChEBI:15756]
name: Palmitate
name: Cetylic acid
xref: UnificationXref2121

http://identifiers.org/pubmed/19111581
type: PublicationXref
id: 19111581
author: Gieselmann, V
author: Ballabio, A
db: Pubmed
title: Lysosomal disorders: from storage to cellular damage
source: Biochim Biophys Acta 1793:684-96
year: 2009

http://identifiers.org/pubmed/10503886
type: PublicationXref
id: 10503886
author: Yoshinari, K
author: Fujita, K
author: Nagata, K
author: Shiraga, T
author: Yamazoe, Y
author: Iwasaki, K
db: Pubmed
title: Sulfotransferase catalyzing sulfation of heterocyclic amines
source: Cancer Lett 143:103-7
year: 1999

UniProt:P40191
type: ProteinReference
xref: UnificationXref3176
organism: BioSource1

beta-Nicotinate D-ribonucleotide
type: SmallMoleculeReference
name: Nicotinate D-ribonucleotide [ChEBI:7561]
name: Nicotinic acid ribonucleotide
name: Nicotinate ribonucleotide
name: Nicotinate D-ribonucleotide
xref: UnificationXref3228

RelationshipXref509
type: RelationshipXref
id: GO:0003842
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite190
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref508
type: RelationshipXref
id: GO:0006559
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite191
type: SequenceSite
position status: EQUAL
sequence position: 295

RelationshipXref507
type: RelationshipXref
id: 4231660
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231660

SequenceSite192
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref506
type: RelationshipXref
id: GO:0004838
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite193
type: SequenceSite
position status: EQUAL
sequence position: 301

RelationshipXref505
type: RelationshipXref
id: GO:0006554
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite194
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref504
type: RelationshipXref
id: 4231607
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231607

SequenceSite195
type: SequenceSite
position status: EQUAL
sequence position: 282

RelationshipXref502
type: RelationshipXref
id: GO:0008652
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite197
type: SequenceSite
position status: EQUAL
sequence position: 420

http://identifiers.org/pubmed/2900981
type: PublicationXref
id: 2900981
author: Palsdottir, A
author: Jensson, O
author: Arnason, A
author: Thorsteinsson, L
author: Grubb, A
author: Abrahamson, M
author: Olafsson, I
db: Pubmed
title: Mutation in cystatin C gene causes hereditary brain haemorrhage
source: Lancet 2:603-4
year: 1988

RelationshipXref503
type: RelationshipXref
id: GO:0047536
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite196
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref500
type: RelationshipXref
id: 4232946
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232946

SequenceSite199
type: SequenceSite
position status: EQUAL
sequence position: 420

RelationshipXref501
type: RelationshipXref
id: GO:0006564
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite198
type: SequenceSite
position status: EQUAL
sequence position: 1

(R)-4'-Phosphopantothenoyl-L-cysteine [ChEBI:328]
type: SmallMoleculeReference
name: (R)-4'-Phosphopantothenoyl-L-cysteine
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
xref: UnificationXref3158

http://identifiers.org/pubmed/12663868
type: PublicationXref
id: 12663868
author: Boyer, JL
author: Trauner, M
db: Pubmed
title: Bile salt transporters: molecular characterization, function, and regulation
source: Physiol Rev 83:633-671
year: 2003

http://identifiers.org/pubmed/16601864
type: PublicationXref
id: 16601864
author: Struys, EA
db: Pubmed
title: D-2-Hydroxyglutaric aciduria: unravelling the biochemical pathway and the genetic defect
source: J Inherit Metab Dis 29:21-9
year: 2006

UniProt:P0AE24
type: ProteinReference
xref: UnificationXref468
organism: BioSource1

RelationshipXref559
type: RelationshipXref
id: 4232240
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232240

http://identifiers.org/pubmed/18767960
type: PublicationXref
id: 18767960
author: Antonellis, A
author: Green, ED
db: Pubmed
title: The role of aminoacyl-tRNA synthetases in genetic diseases
source: Annu Rev Genomics Hum Genet 9:87-107
year: 2008

http://identifiers.org/pubmed/16819626
type: PublicationXref
id: 16819626
author: Becherer, U
author: Rettig, J
db: Pubmed
title: Vesicle pools, docking, priming, and release
source: Cell Tissue Res 326:393-407
year: 2006

http://identifiers.org/pubmed/8063828
type: PublicationXref
id: 8063828
author: Frigeri, A
author: Ma, T
author: Verkman, AS
author: Hasegawa, H
db: Pubmed
title: Cloning of a water channel homolog expressed in brain meningeal cells and kidney collecting duct that functions as a stilbene-sensitive glycerol transporter
source: J Biol Chem 269:21845-9
year: 1994

FADH2
type: SmallMoleculeReference
name: FADH2 [ChEBI:17877]
xref: UnificationXref2041

http://identifiers.org/pubmed/9443878
type: PublicationXref
id: 9443878
author: Neufeld, Elizabeth F
author: Tieu, P
author: Huang, Y
author: Di Natale, P
author: Zhao, HZ
author: Li, HH
author: Zhao, HG
author: Greenberg, D
author: Cheng, S
author: Whitley, CB
author: Zhao, Z
author: Schmidtchen, A
db: Pubmed
title: NAGLU mutations underlying Sanfilippo syndrome type B
source: Am J Hum Genet 62:64-9
year: 1998

SequenceSite129
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/18201392
type: PublicationXref
id: 18201392
author: Clarke, LA
db: Pubmed
title: The mucopolysaccharidoses: a success of molecular medicine
source: Expert Rev Mol Med 10:e1
year: 2008

RelationshipXref550
type: RelationshipXref
id: GO:0004655
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite127
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite128
type: SequenceSite
position status: EQUAL
sequence position: 541

RelationshipXref552
type: RelationshipXref
id: GO:0004418
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite125
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/11467836
type: PublicationXref
id: 11467836
author: Bergström, J
author: Eulitz, M
author: Westermark, P
author: Weiss, DT
author: Murphy, C
author: Solomon, A
author: Westermark, GT
db: Pubmed
title: Codeposition of apolipoprotein A-IV and transthyretin in senile systemic (ATTR) amyloidosis
source: Biochem Biophys Res Commun 285:903-8
year: 2001

RelationshipXref551
type: RelationshipXref
id: 4232234
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232234

SequenceSite126
type: SequenceSite
position status: EQUAL
sequence position: 541

RelationshipXref554
type: RelationshipXref
id: GO:0004853
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite123
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref553
type: RelationshipXref
id: 4232216
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232216

SequenceSite124
type: SequenceSite
position status: EQUAL
sequence position: 541

RelationshipXref556
type: RelationshipXref
id: GO:0004109
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite121
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref555
type: RelationshipXref
id: 4232228
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232228

SequenceSite122
type: SequenceSite
position status: EQUAL
sequence position: 644

RelationshipXref558
type: RelationshipXref
id: GO:0004325
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref557
type: RelationshipXref
id: 4232222
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232222

SequenceSite120
type: SequenceSite
position status: EQUAL
sequence position: 652

Ethylenesuccinic acid
type: SmallMoleculeReference
name: Butanedionic acid
name: Succinate [ChEBI:15741]
name: Succinate
name: Succinic acid
xref: UnificationXref1200

http://identifiers.org/pubmed/1590793
type: PublicationXref
id: 1590793
author: Waltenberger, J
author: Usuki, K
author: Heldin, CH
author: Pierce, G
author: Thomason, A
author: Miyazono, K
author: Saras, J
db: Pubmed
title: Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.
source: Biochem Biophys Res Commun 184:1311-6
year: 1992

RelationshipXref561
type: RelationshipXref
id: 4233304
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233304

SequenceSite138
type: SequenceSite
position status: EQUAL
sequence position: 681

RelationshipXref560
type: RelationshipXref
id: GO:0008495
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite139
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref565
type: RelationshipXref
id: 4232680
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232680

SequenceSite134
type: SequenceSite
position status: EQUAL
sequence position: 617

RelationshipXref564
type: RelationshipXref
id: GO:0003987
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite135
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref563
type: RelationshipXref
id: GO:0006778
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite136
type: SequenceSite
position status: EQUAL
sequence position: 672

RelationshipXref562
type: RelationshipXref
id: GO:0006783
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite137
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref569
type: RelationshipXref
id: GO:0003979
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite130
type: SequenceSite
position status: EQUAL
sequence position: 617

RelationshipXref568
type: RelationshipXref
id: GO:0006805
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite131
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref567
type: RelationshipXref
id: GO:0006069
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite132
type: SequenceSite
position status: EQUAL
sequence position: 617

RelationshipXref566
type: RelationshipXref
id: 4231761
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231761

SequenceSite133
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2402
type: UnificationXref
id: REACT_151292
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151292.1

UnificationXref2403
type: UnificationXref
id: 4233221
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233221

UnificationXref2400
type: UnificationXref
id: CHEBI:63993
db: ChEBI

UnificationXref2401
type: UnificationXref
id: 2142690
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142690

RelationshipXref537
type: RelationshipXref
id: GO:0046487
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite140
type: SequenceSite
position status: EQUAL
sequence position: 718

RelationshipXref538
type: RelationshipXref
id: GO:0004123
db: GENE ONTOLOGY
relationship type: MI:0355

MPS IIIC - Sanfilippo syndrome C
type: Pathway
data source: Provenance1
pathway component: Glycosaminoglycan metabolism
evidence: Evidence219
xref: UnificationXref1414
xref: UnificationXref1415
pathway order: PathwayStep202
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref539
type: RelationshipXref
id: 4233132
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233132

http://identifiers.org/pubmed/15491402
type: PublicationXref
id: 15491402
author: Jensen, FB
db: Pubmed
title: Red blood cell pH, the Bohr effect, and other oxygenation-linked phenomena in blood O2 and CO2 transport
source: Acta Physiol Scand 182:215-27
year: 2004

SequenceSite149
type: SequenceSite
position status: EQUAL
sequence position: 1

Glutathione disulfide
type: SmallMoleculeReference
name: Oxidized glutathione [ChEBI:17858]
name: GSSG
name: Oxidized glutathione
xref: UnificationXref2345

RelationshipXref534
type: RelationshipXref
id: 4232485
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232485

SequenceSite143
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref533
type: RelationshipXref
id: GO:0008891
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite144
type: SequenceSite
position status: EQUAL
sequence position: 629

RelationshipXref536
type: RelationshipXref
id: 4232487
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232487

UnificationXref2409
type: UnificationXref
id: 4233036
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233036

SequenceSite141
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref535
type: RelationshipXref
id: GO:0047969
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2408
type: UnificationXref
id: REACT_148805
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148805.4

SequenceSite142
type: SequenceSite
position status: EQUAL
sequence position: 675

RelationshipXref530
type: RelationshipXref
id: GO:0006595
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2407
type: UnificationXref
id: 4233435
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233435

SequenceSite147
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2406
type: UnificationXref
id: REACT_153210
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153210.3

SequenceSite148
type: SequenceSite
position status: EQUAL
sequence position: 629

RelationshipXref532
type: RelationshipXref
id: 4232478
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232478

UnificationXref2405
type: UnificationXref
id: 4233539
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233539

SequenceSite145
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/8114698
type: PublicationXref
id: 8114698
author: Nevins, JR
author: Ohtani, K
db: Pubmed
title: Functional properties of a Drosophila homolog of the E2F1 gene
source: Mol Cell Biol 14:1603-12
year: 1994

RelationshipXref531
type: RelationshipXref
id: GO:0030267
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2404
type: UnificationXref
id: REACT_154526
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154526.3

SequenceSite146
type: SequenceSite
position status: EQUAL
sequence position: 629

RelationshipXref548
type: RelationshipXref
id: GO:0000096
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite151
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref549
type: RelationshipXref
id: GO:0034641
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite150
type: SequenceSite
position status: EQUAL
sequence position: 323

Sedoheptulose 7-phosphate [ChEBI:15721]
type: SmallMoleculeReference
name: altro-Heptulose 7-phosphate
name: Sedoheptulose 7-phosphate
xref: UnificationXref1708

Citric acid cycle (TCA cycle)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction212
pathway component: BiochemicalReaction211
pathway component: BiochemicalReaction210
pathway component: BiochemicalReaction209
pathway component: BiochemicalReaction116
evidence: Evidence402
xref: UnificationXref2602
xref: UnificationXref2601
xref: RelationshipXref350
pathway order: PathwayStep387
pathway order: PathwayStep386
pathway order: PathwayStep227
pathway order: PathwayStep388
pathway order: PathwayStep385
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Palmitoylglycerone phosphate [ChEBI:7900]
type: SmallMoleculeReference
name: Palmitoylglycerone phosphate
xref: UnificationXref2106

(S)-2,5-Diaminopentanoate
type: SmallMoleculeReference
name: (S)-2,5-Diaminopentanoic acid
name: (S)-2,5-diaminovaleric acid
name: L-Ornithine [ChEBI:15729]
name: L-Ornithine
xref: UnificationXref3482

RelationshipXref547
type: RelationshipXref
id: GO:0000098
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite152
type: SequenceSite
position status: EQUAL
sequence position: 388

RelationshipXref546
type: RelationshipXref
id: 4233129
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233129

SequenceSite153
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref545
type: RelationshipXref
id: GO:0016846
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite154
type: SequenceSite
position status: EQUAL
sequence position: 369

RelationshipXref544
type: RelationshipXref
id: 4233134
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233134

SequenceSite155
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref543
type: RelationshipXref
id: GO:0080146
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite156
type: SequenceSite
position status: EQUAL
sequence position: 649

RelationshipXref542
type: RelationshipXref
id: 4233138
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233138

SequenceSite157
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref541
type: RelationshipXref
id: GO:0047982
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite158
type: SequenceSite
position status: EQUAL
sequence position: 649

RelationshipXref540
type: RelationshipXref
id: GO:0019346
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite159
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/1559981
type: PublicationXref
id: 1559981
author: Dupret, JM
author: Grant, DM
db: Pubmed
title: Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2.
source: J Biol Chem 267:7381-5
year: 1992

http://identifiers.org/pubmed/16990140
type: PublicationXref
id: 16990140
author: Dai, H
author: Sudhof, TC
author: Maximov, A
author: Tang, J
author: Rizo, J
author: Shin, OH
db: Pubmed
title: A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
source: Cell 126:1175-87
year: 2006

UniProt:P06610
type: ProteinReference
xref: UnificationXref2351
organism: BioSource1

Glucose transport by class III GLUTs
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence69
xref: UnificationXref479
xref: UnificationXref478
left: alpha-D-glucose
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: alpha-D-glucose

Transport (influx) of glucose, galactose, and sodium ions by SGLT1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence67
xref: UnificationXref463
xref: UnificationXref462
participant stoichiometry: Stoichiometry38
participant stoichiometry: Stoichiometry39
left: SmallMolecule2
left: hexoses transported by SGLT1
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: hexoses transported by SGLT1
right: Sodium

Type III Na+/Pi cotransport
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence64
xref: UnificationXref440
xref: UnificationXref439
participant stoichiometry: Stoichiometry37
participant stoichiometry: Stoichiometry36
left: SmallMolecule2
left: inorganic phosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Phosphate
right: Sodium

Electroneutral Na+/Pi cotransport
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence62
xref: UnificationXref426
xref: UnificationXref427
participant stoichiometry: Stoichiometry35
participant stoichiometry: Stoichiometry34
left: SmallMolecule2
left: inorganic phosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Phosphate
right: Sodium

Na+/H+ exchanger transport (at late endosome membrane)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence59
xref: UnificationXref415
xref: UnificationXref416
left: H+
left: Sodium
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Sodium ion
right: proton

Electrogenic Na+/Pi cotransport
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence61
xref: UnificationXref424
xref: UnificationXref423
participant stoichiometry: Stoichiometry32
participant stoichiometry: Stoichiometry33
left: SmallMolecule2
left: inorganic phosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Phosphate
right: Sodium

Na+/H+ exchanger transport (at early endosome membrane)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence57
xref: UnificationXref397
xref: UnificationXref398
left: H+
left: Sodium
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: proton
right: Sodium ion

Na+/H+ exchanger transport (at trans-golgi membrane)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence58
xref: UnificationXref407
xref: UnificationXref408
left: H+
left: Sodium
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: proton
right: Sodium

ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence53
xref: UnificationXref376
xref: UnificationXref377
left: Water
left: long-chain fatty acids
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Phosphate
right: Adenosine 5'-diphosphate
right: long-chain fatty acids

Na+/H+ exchanger transport (at cell membrane)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence56
xref: UnificationXref390
xref: UnificationXref389
left: SmallMolecule2
left: proton
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1
right: Sodium

S-Adenosyl-L-homocysteine
type: SmallMoleculeReference
name: S-Adenosyl-L-homocysteine [ChEBI:16680]
name: S-Adenosylhomocysteine
xref: UnificationXref2490

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction208
pathway component: BiochemicalReaction207
evidence: Evidence395
xref: UnificationXref2558
xref: UnificationXref2557
pathway order: PathwayStep380
pathway order: PathwayStep381
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 79998.9
pathway component: REACT 97734.9
pathway component: REACT 115343.8
pathway component: REACT 134639.5
pathway component: REACT 103710.9
pathway component: Biological oxidations
pathway component: REACT 105321.9
pathway component: REACT 136663.5
pathway component: Inositol phosphate metabolism
pathway component: REACT 79340.9
pathway component: REACT 97832.9
pathway component: Metabolism of nucleotides
pathway component: REACT 140852.5
evidence: Evidence590
xref: RelationshipXref585
xref: UnificationXref3893
xref: UnificationXref3892
pathway order: PathwayStep375
pathway order: PathwayStep567
pathway order: PathwayStep261
pathway order: PathwayStep396
pathway order: PathwayStep459
pathway order: PathwayStep497
pathway order: PathwayStep540
pathway order: PathwayStep572
pathway order: PathwayStep550
pathway order: PathwayStep576
pathway order: PathwayStep379
pathway order: PathwayStep266
pathway order: PathwayStep384
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/2340091
type: PublicationXref
id: 2340091
author: McBride, W
author: Blum, M
author: Heim, M
author: Grant, DM
author: Meyer, UA
db: Pubmed
title: Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression
source: DNA Cell Biol 9:193-203
year: 1990

Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence85
xref: UnificationXref593
xref: UnificationXref592
left: SmallMolecule2
left: ligands of SLC28A1
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: ligands of SLC28A1
right: Sodium

ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence80
xref: UnificationXref546
xref: UnificationXref547
left: Zn(II)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Zinc 2+

Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence86
xref: UnificationXref613
xref: UnificationXref612
participant stoichiometry: Stoichiometry45
participant stoichiometry: Stoichiometry44
left: SmallMolecule2
left: SmallMolecule103
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule106
right: Sodium

Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence75
xref: UnificationXref518
xref: UnificationXref517
participant stoichiometry: Stoichiometry42
participant stoichiometry: Stoichiometry43
left: SmallMolecule2
left: Inositols transported by SMIT2
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Inositols transported by SMIT2
right: Sodium

HMIT co-transports myo-inositol with a proton
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence76
xref: UnificationXref524
xref: UnificationXref523
left: SmallMolecule1
left: Inositol
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: proton
right: Inositol

ZnT2 facilitates zinc vesicular sequestration
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence78
xref: UnificationXref536
xref: UnificationXref535
left: Zn(II)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Zn(II)

ZnT3 transports zinc into synaptic vesicles
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence79
xref: UnificationXref541
xref: UnificationXref540
left: Zn(II)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: zinc

Co-transport (influx) of glucose and Na+ ions by SGLT2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence71
xref: UnificationXref484
xref: UnificationXref483
left: SmallMolecule2
left: alpha-D-glucose
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: alpha-D-glucose
right: Sodium

Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence72
xref: UnificationXref495
xref: UnificationXref496
left: SmallMolecule2
left: hexoses transported by SGLT4
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: hexoses transported by SGLT4
right: Sodium

Uridine 5'-monophosphate
type: SmallMoleculeReference
name: Uridine monophosphate
name: UMP [ChEBI:16695]
name: Uridylic acid
name: UMP
name: 5'Uridylic acid
xref: UnificationXref2926

Co-transport (influx) of myo-inositol and two Na+ ions by SMIT
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence74
xref: UnificationXref506
xref: UnificationXref505
participant stoichiometry: Stoichiometry40
participant stoichiometry: Stoichiometry41
left: SmallMolecule2
left: Inositol
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Inositol
right: Sodium

http://identifiers.org/pubmed/1431593
type: PublicationXref
id: 1431593
author: Coates, PM
author: Tanaka, K
db: Pubmed
title: Molecular basis of mitochondrial fatty acid oxidation defects.
source: J Lipid Res 33:1099-110
year: 1992

Passive Transport of Water into Cell by Aquaporin-1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence100
xref: UnificationXref717
xref: UnificationXref718
left: SmallMolecule111
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water

Passive Transport of Urea out of Cells by Aquaporins
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence98
xref: UnificationXref714
xref: UnificationXref713
left: SmallMolecule127
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule126

Passive Transport of Water out of Cells by Aquaporins
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence92
xref: UnificationXref658
xref: UnificationXref659
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule111

http://identifiers.org/pubmed/15581364
type: PublicationXref
id: 15581364
author: Zhai, H
author: McLafferty, FW
author: Brand, LA
author: Begley, TP
author: Strauss, E
db: Pubmed
title: Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent
source: Biochemistry 43:15520-33
year: 2004

Passive Transport of Anions into Vesicles by Aquaporin-6
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence93
xref: UnificationXref693
xref: UnificationXref692
left: SmallMolecule112
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule118

Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence87
xref: UnificationXref622
xref: UnificationXref623
left: SmallMolecule109
left: SmallMolecule2
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule110
right: Sodium

Passive Transport of Water into Cells by Aquaporins
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence91
xref: UnificationXref656
xref: UnificationXref657
left: SmallMolecule111
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water

Passive Transport of Glycerol out of Cells by Aquaporins
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence96
xref: UnificationXref704
xref: UnificationXref703
left: SmallMolecule125
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule124

Passive Transport of Urea into Cells by Aquaporins
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence97
xref: UnificationXref712
xref: UnificationXref711
left: SmallMolecule126
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule127

Passive Transport of Anions out of Vesicles by Aquaporin-6
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence94
xref: UnificationXref694
xref: UnificationXref693
left: SmallMolecule118
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule112

Passive Transport of Glycerol into Cells by Aquaporins
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence95
xref: UnificationXref702
xref: UnificationXref701
left: SmallMolecule124
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule125

http://identifiers.org/pubmed/12213784
type: PublicationXref
id: 12213784
author: Gallo, RL
author: Trowbridge, JM
db: Pubmed
title: Dermatan sulfate: new functions from an old glycosaminoglycan
source: Glycobiology 12:117R-25R
year: 2002

http://identifiers.org/pubmed/8050359
type: PublicationXref
id: 8050359
author: Duronio, RJ
author: O'Farrell, PH
db: Pubmed
title: Developmental control of a G1-S transcriptional program in Drosophila
source: Development 120:1503-15
year: 1994

ROS oxidize thioredoxin
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence116
xref: UnificationXref782
xref: UnificationXref783
left: SASP
left: SmallMolecule134
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SASP

http://identifiers.org/pubmed/10037775
type: PublicationXref
id: 10037775
author: Hu, CA
author: Valle, D
author: Obie, C
author: Lin, WW
db: Pubmed
title: Molecular enzymology of mammalian Delta1-pyrroline-5-carboxylate synthase. Alternative splice donor utilization generates isoforms with different sensitivity to ornithine inhibition
source: J Biol Chem 274:6754-62
year: 1999

Passive Transport of Water out of Cell by Aquaporin-1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence102
xref: UnificationXref722
xref: UnificationXref721
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule111

Passive Transport of Water out of Cell by Aquaporin-3
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence103
xref: UnificationXref723
xref: UnificationXref724
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule111

Passive Transport of Water out of Cell by Aquaporin-4
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence104
xref: UnificationXref725
xref: UnificationXref726
left: Water
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule111

http://identifiers.org/pubmed/10522552
type: PublicationXref
id: 10522552
author: Ponka, P
db: Pubmed
title: Cell biology of heme
source: Am J Med Sci 318:241-56
year: 1999

Passive Transport of Glycerol out of Cell by Aquaporin-7
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence106
xref: UnificationXref730
xref: UnificationXref729
left: SmallMolecule125
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule124

Passive Transport of Glycerol into Cell by Aquaporin-9
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence107
xref: UnificationXref732
xref: UnificationXref731
left: SmallMolecule124
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule125

http://identifiers.org/pubmed/17513417
type: PublicationXref
id: 17513417
author: Wang, Y
author: Tajkhorshid, E
db: Pubmed
title: Molecular mechanisms of conduction and selectivity in aquaporin water channels
source: J Nutr 137:1509S-1515S
year: 2007

SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence110
xref: UnificationXref747
xref: UnificationXref748
left: Phosphate
left: Sodium
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule129
right: SmallMolecule128

SLC17A3-2 transports cytosolic urate to extracellular region
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence111
xref: UnificationXref759
xref: UnificationXref760
left: SmallMolecule130
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule131

SLC9C1 exchanges Na+ for H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence112
xref: UnificationXref767
xref: UnificationXref768
left: SmallMolecule2
left: SmallMolecule132
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule1
right: SmallMolecule133

Passive Transport of Water into Cell by Aquaporin-2 Phosphorylated on Serine256
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence101
xref: UnificationXref720
xref: UnificationXref719
left: SmallMolecule111
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water

http://identifiers.org/pubmed/8644704
type: PublicationXref
id: 8644704
author: Young, E P
author: Lissens, W
author: Fensom, A
author: Islam, M R
author: Zabot, M T
author: Kleijer, W J
author: Chabas, A
author: Vervoort, R
author: Liebaers, I
author: Sly, W S
db: Pubmed
title: Molecular analysis of patients with beta-glucuronidase deficiency presenting as hydrops fetalis or as early mucopolysaccharidosis VII
source: Am. J. Hum. Genet. 58:457-71
year: 1996

UniProt:P69924
type: ProteinReference
xref: UnificationXref1230
organism: BioSource1

http://identifiers.org/pubmed/12543708
type: PublicationXref
id: 12543708
author: Russell, DW
db: Pubmed
title: The enzymes, regulation, and genetics of bile acid synthesis
source: Annu Rev Biochem 72:137-74
year: 2003

UnificationXref3218
type: UnificationXref
id: REACT_4937
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4937.2

UnificationXref3219
type: UnificationXref
id: 4233300
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233300

http://identifiers.org/pubmed/8751852
type: PublicationXref
id: 8751852
author: Kondo, N
author: Vobecky, S
author: Duncan, AM
author: Mitchell, GA
author: Perez-Cerda, C
author: Song, XQ
author: Kassovska-Bratinova, S
author: Chartrand, C
author: Ugarte, M
author: Chen, HS
author: Fukao, T
author: Robert, MF
db: Pubmed
title: Succinyl CoA: 3-oxoacid CoA transferase (SCOT): human cDNA cloning, human chromosomal mapping to 5p13, and mutation detection in a SCOT-deficient patient
source: Am J Hum Genet 59:519-28
year: 1996

UnificationXref3211
type: UnificationXref
id: 4233307
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233307

tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence127
EC number: 6.1.1.1
xref: UnificationXref825
xref: UnificationXref826
left: SmallMolecule135
left: SmallMolecule136
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule139
right: SmallMolecule137
right: SmallMolecule138

UnificationXref3210
type: UnificationXref
id: REACT_147076
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147076.5

Release of platelet cytosolic components
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence122
xref: UnificationXref797
xref: UnificationXref798
left: Note: the coordinates are copied over from Homo sapiens.
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Note: the coordinates are copied over from Homo sapiens.

UnificationXref3213
type: UnificationXref
id: 4233334
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233334

UnificationXref3212
type: UnificationXref
id: REACT_167588
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_167588.1

UnificationXref3215
type: UnificationXref
id: MOD:00126
db: MOD

UnificationXref3214
type: UnificationXref
id: REACT_167368
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_167368.1

UnificationXref3217
type: UnificationXref
id: 29418
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29418

The NLRP3 inflammasome
type: Pathway
data source: Provenance1
pathway component: ROS oxidize thioredoxin
evidence: Evidence117
xref: UnificationXref785
xref: UnificationXref784
pathway order: PathwayStep109
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3216
type: UnificationXref
id: 4233299
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233299

proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence136
EC number: 6.1.1.15
xref: UnificationXref937
xref: UnificationXref936
left: SmallMolecule164
left: SmallMolecule140
left: SmallMolecule165
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule143
right: SmallMolecule166
right: SmallMolecule144

Hydroxymethylbilane [ChEBI:5809]
type: SmallMoleculeReference
name: Hydroxymethylbilane
xref: UnificationXref3646

phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence135
EC number: 6.1.1.20
xref: UnificationXref923
xref: UnificationXref924
left: SmallMolecule161
left: SmallMolecule140
left: SmallMolecule162
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule143
right: SmallMolecule144
right: SmallMolecule163

leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence134
EC number: 6.1.1.4
xref: UnificationXref910
xref: UnificationXref911
left: SmallMolecule140
left: SmallMolecule159
left: SmallMolecule158
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule143
right: SmallMolecule160
right: SmallMolecule144

L-2-Amino-4methylthiobutyric acid
type: SmallMoleculeReference
name: L-Methionine
name: L-Methionine [ChEBI:16643]
xref: UnificationXref3321

isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence133
EC number: 6.1.1.5
xref: UnificationXref898
xref: UnificationXref897
left: SmallMolecule156
left: SmallMolecule155
left: SmallMolecule140
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule143
right: SmallMolecule157
right: SmallMolecule144

glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence132
EC number: 6.1.1.18
xref: UnificationXref884
xref: UnificationXref885
left: SmallMolecule140
left: SmallMolecule152
left: SmallMolecule153
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule154
right: SmallMolecule143
right: SmallMolecule144

glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence131
EC number: 6.1.1.17
xref: UnificationXref872
xref: UnificationXref873
left: SmallMolecule149
left: SmallMolecule140
left: SmallMolecule150
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule143
right: SmallMolecule151
right: SmallMolecule144

aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence130
EC number: 6.1.1.12
xref: UnificationXref860
xref: UnificationXref861
left: SmallMolecule140
left: SmallMolecule146
left: SmallMolecule147
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule143
right: SmallMolecule148
right: SmallMolecule144

asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence129
EC number: 6.1.1.22
xref: UnificationXref848
xref: UnificationXref847
left: SmallMolecule140
left: SmallMolecule142
left: SmallMolecule141
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule145
right: SmallMolecule143
right: SmallMolecule144

http://identifiers.org/pubmed/2995393
type: PublicationXref
id: 2995393
author: Fitzpatrick, F
author: McGee, J
db: Pubmed
title: Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes
source: J Biol Chem 260:12832-7
year: 1985

UnificationXref3209
type: UnificationXref
id: 4233491
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233491

UnificationXref3207
type: UnificationXref
id: 4232922
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232922

UnificationXref3208
type: UnificationXref
id: REACT_145908
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145908.5

UniProt:P76641
type: ProteinReference
xref: UnificationXref2869
organism: BioSource1

UnificationXref3202
type: UnificationXref
id: P0AFI7
db: UniProt

serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence137
EC number: 6.1.1.11
xref: UnificationXref949
xref: UnificationXref950
left: SmallMolecule168
left: SmallMolecule140
left: SmallMolecule167
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule143
right: SmallMolecule169
right: SmallMolecule144

UnificationXref3201
type: UnificationXref
id: REACT_5251
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5251.2

UnificationXref3200
type: UnificationXref
id: 29368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29368

tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence139
EC number: 6.1.1.1
xref: UnificationXref973
xref: UnificationXref974
left: SmallMolecule140
left: SmallMolecule173
left: SmallMolecule174
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule143
right: SmallMolecule144
right: SmallMolecule175

tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence138
EC number: 6.1.1.2
xref: UnificationXref962
xref: UnificationXref963
left: SmallMolecule140
left: SmallMolecule171
left: SmallMolecule170
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule143
right: SmallMolecule144
right: SmallMolecule172

UnificationXref3206
type: UnificationXref
id: REACT_132960
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132960.5

UnificationXref3205
type: UnificationXref
id: 4232923
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232923

UnificationXref3204
type: UnificationXref
id: 4232920
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232920

UnificationXref3203
type: UnificationXref
id: 4232919
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232919

Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence153
xref: UnificationXref1102
xref: UnificationXref1101
left: SmallMolecule201
left: Homologues of GalNAc-MUC21
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Homologues of Core 7 (MUC21)
right: SmallMolecule200

Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence152
xref: UnificationXref1093
xref: UnificationXref1094
left: SmallMolecule199
left: Homologues of GalNAc-MUC21
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Homologues of Core 6 (MUC21)
right: SmallMolecule200

Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence154
xref: UnificationXref1110
xref: UnificationXref1109
left: Homologues of GalNAc-MUC21
left: SmallMolecule202
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule200
right: Homologues of Core 8 (MUC21)

Translocation of ribosome by 3 bases in the 3' direction
type: BiochemicalReaction
data source: Provenance1
xref: http://identifiers.org/pubmed/7027051
xref: http://identifiers.org/pubmed/1703007
xref: UnificationXref1046
xref: http://identifiers.org/pubmed/4921478
xref: UnificationXref1045
left: Elongation complex with growing peptide chain
comment: At the beginning of this reaction, 1 molecule of 'Elongation complex with growing peptide chain' is present. At the end of this reaction, 1 molecule of '70S:mRNA:peptidyl-tRNA with elongating peptide' is present.
right: 70S:mRNA:peptidyl-tRNA with elongating peptide

UDP-N-acetyl-D-galactosamine
type: SmallMoleculeReference
name: UDP-N-acetyl-D-galactosamine [ChEBI:9820]
xref: UnificationXref1095

Peptide transfer from P-site tRNA to the A-site tRNA
type: BiochemicalReaction
data source: Provenance1
xref: http://identifiers.org/pubmed/12297040
xref: http://identifiers.org/pubmed/4921478
xref: UnificationXref1042
xref: UnificationXref1041
left: 70S:Met-tRNAi:mRNA:aa-tRNA
comment: At the beginning of this reaction, 1 molecule of '70S:Met-tRNAi:mRNA:aa-tRNA' is present. At the end of this reaction, 1 molecule of 'Elongation complex with growing peptide chain' is present.
right: Elongation complex with growing peptide chain

Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence151
xref: UnificationXref1089
xref: UnificationXref1088
left: SmallMolecule199
left: Homologues of GalNAc-MUC21
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Homologues of Core 5 (MUC21)
right: SmallMolecule200

Fructose 6-phosphate isomerizes to Mannose 6-phosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence146
EC number: 5.3.1.8
xref: UnificationXref1064
xref: UnificationXref1063
left: SmallMolecule197
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule198

http://identifiers.org/pubmed/9718352
type: PublicationXref
id: 9718352
author: De Abreu, R
author: Imaeda, M
author: Hamajima, N
author: Rotteveel, J
author: Kidouchi, K
author: Endo, Y
author: Matsuda, K
author: Togari, H
author: Ohba, S
author: Vreken, P
author: Sasaki, M
author: Tamaki, N
author: Kouwaki, M
author: van Kuilenburg, A
author: Nonaka, M
author: Wada, Y
author: van Gennip, A
author: Sumi, S
db: Pubmed
title: Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene
source: Am J Hum Genet 63:717-26
year: 1998

Conversion of GABA to Succinate Semialdehyde
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence174
EC number: 2.6.1.19
xref: UnificationXref1196
xref: UnificationXref1195
left: SmallMolecule209
left: SmallMolecule208
left: SmallMolecule207
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule210
right: SmallMolecule150
right: SmallMolecule207

2'-deoxyinosine
type: SmallMoleculeReference
name: deoxyinosine
name: 2'-deoxyinosine [ChEBI:28997]
xref: UnificationXref2766

L-Glutamate uptake by neurons
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence172
xref: UnificationXref1177
xref: UnificationXref1176
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Glutaminic acid

glutamine + H2O => glutamate + NH4+ [GLS]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence171
EC number: 3.5.1.2
xref: UnificationXref1173
xref: UnificationXref1174
left: SmallMolecule205
left: SmallMolecule153
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule206
right: SmallMolecule150

Estrone is hydrogenated to estradiol
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence168
EC number: 1.1.1.62
xref: UnificationXref1151
xref: RelationshipXref130
xref: UnificationXref1152
left: SmallMolecule203
left: NADPH
left: proton
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: SmallMolecule204

Amyloid precursor proteins form ordered fibrils
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence194
xref: UnificationXref1281
xref: UnificationXref1282
left: Note: the coordinates are copied over from Homo sapiens.
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: PhysicalEntity22

HSP90 is inactivated by binding to benzaquinoid ansamycins
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence191
xref: UnificationXref1270
xref: UnificationXref1271
participant stoichiometry: Stoichiometry76
left: SmallMolecule214
left: HSP90 (name copied from entity in Homo sapiens)
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: HSP90:Benzoquinoid ansamycins (name copied from entity in Homo sapiens)

intracellular
type: CellularLocationVocabulary
xref: UnificationXref66

glutamate uptake by astrocytes
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence179
xref: UnificationXref1217
xref: UnificationXref1177
left: SmallMolecule5
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Glutaminic acid

Conversion of succinate semialdehyde to succinate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence175
EC number: 1.2.1.24
xref: UnificationXref1208
xref: UnificationXref1209
left: SmallMolecule211
left: SmallMolecule210
left: SmallMolecule205
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule213
right: SmallMolecule212

Beta-glucuronidase (GUSB) hydrolyses glucuronate from the HA disaccharides
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence197
EC number: 3.2.1.31
xref: UnificationXref1304
xref: UnificationXref1305
left: SmallMolecule222
left: SmallMolecule220
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule221
right: SmallMolecule223

Beta-glucuronidase (GUSB) hydrolyses glucuronate from HA tetrasaccharides
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence196
EC number: 3.2.1.31
xref: UnificationXref1297
xref: UnificationXref1296
left: SmallMolecule220
left: PhysicalEntity25
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule221
right: PhysicalEntity26

http://identifiers.org/pubmed/18768791
type: PublicationXref
id: 18768791
author: Horsefield, R
author: Neutze, R
author: Nordén, K
author: Törnroth-Horsefield, S
author: Johanson, U
author: Terwisscha van Scheltinga, AC
author: Kvassman, J
author: Fellert, M
author: Kjellbom, P
author: Backmark, A
db: Pubmed
title: High-resolution x-ray structure of human aquaporin 5
source: Proc Natl Acad Sci U S A 105:13327-32
year: 2008

http://identifiers.org/pubmed/7706277
type: PublicationXref
id: 7706277
author: Lou, L
author: Nakamura, J
db: Pubmed
title: Biochemical characterization of human GMP synthetase
source: J Biol Chem 270:7347-7353
year: 1995

http://identifiers.org/pubmed/10856300
type: PublicationXref
id: 10856300
author: Tirasophon, W
author: Kaufman, RJ
author: Shen, J
author: Wang, Y
author: Prywes, R
author: Arenzana, N
db: Pubmed
title: Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response
source: J Biol Chem 275:27013-20
year: 2000

http://identifiers.org/pubmed/13575436
type: PublicationXref
id: 13575436
author: Robbins, PW
author: Lipmann, F
db: Pubmed
title: Separation of the two enzymatic phases in active sulfate synthesis
source: J Biol Chem 233:681-5
year: 1958

UniProt:P25889
type: ProteinReference
xref: UnificationXref3007
organism: BioSource1

UnificationXref3252
type: UnificationXref
id: REACT_29962
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29962.10

http://identifiers.org/pubmed/20303873
type: PublicationXref
id: 20303873
author: Tschopp, J
author: Schroder, K
db: Pubmed
title: The inflammasomes
source: Cell 140:821-32
year: 2010

UnificationXref3253
type: UnificationXref
id: 4233426
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233426

UnificationXref3250
type: UnificationXref
id: REACT_11101
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11101.2

UnificationXref3251
type: UnificationXref
id: 4233427
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233427

UnificationXref3256
type: UnificationXref
id: 197965
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197965

UnificationXref3257
type: UnificationXref
id: REACT_11969
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11969.2

UnificationXref3254
type: UnificationXref
id: REACT_96854
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96854.9

MPS IIIB - Sanfilippo syndrome B
type: Pathway
data source: Provenance1
pathway component: Glycosaminoglycan metabolism
evidence: Evidence218
xref: UnificationXref1412
xref: UnificationXref1413
pathway order: PathwayStep202
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3255
type: UnificationXref
id: CHEBI:27470
db: ChEBI

cyclopropylamine
type: SmallMolecule
entity reference: CHEBI:34660
data source: Provenance1
xref: UnificationXref3876
xref: UnificationXref3877
cellular location: GO:0005829
comment: Reactome DB_ID: 2161175
display name: xenobiotic

UnificationXref3258
type: UnificationXref
id: 4232282
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232282

abacavir monophosphate
type: SmallMolecule
entity reference: abacavir monophosphate [ChEBI:64112]
data source: Provenance1
xref: UnificationXref3874
xref: UnificationXref3873
cellular location: GO:0005829
comment: Reactome DB_ID: 2161194
display name: xenobiotic

UnificationXref3259
type: UnificationXref
id: 4232284
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232284

carbovir diphosphate
type: SmallMolecule
entity reference: carbovir diphosphate [ChEBI:64172]
data source: Provenance1
xref: UnificationXref3885
xref: UnificationXref3884
cellular location: GO:0005829
comment: Reactome DB_ID: 2162075
display name: xenobiotic

carbovir monophosphate
type: SmallMolecule
entity reference: carbovir monophosphate [ChEBI:64116]
data source: Provenance1
xref: UnificationXref3880
xref: UnificationXref3879
cellular location: GO:0005829
comment: Reactome DB_ID: 2161176
display name: xenobiotic

Ketone body metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 93975.9
pathway component: REACT 93528.9
evidence: Evidence322
xref: UnificationXref2035
xref: UnificationXref2034
xref: RelationshipXref255
pathway order: PathwayStep305
pathway order: PathwayStep308
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10958673
type: PublicationXref
id: 10958673
author: Yoshida, H
author: Haze, K
author: Yura, T
author: Yanagi, H
author: Mori, K
author: Okada, T
author: Negishi, M
db: Pubmed
title: ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
source: Mol Cell Biol 20:6755-67
year: 2000

UnificationXref3240
type: UnificationXref
id: CHEBI:17154
db: ChEBI

http://identifiers.org/pubmed/19935646
type: PublicationXref
id: 19935646
author: Jang, HG
author: Dang, L
author: Keenan, MC
author: Vander Heiden, MG
author: Bennett, BD
author: Rabinowitz, JD
author: Driggers, EM
author: Gross, S
author: Ward, PS
author: Fantin, VR
author: Thompson, CB
author: Cantley, LC
author: Marks, KM
author: White, DW
author: Bittinger, MA
author: Prins, RM
author: Su, SM
author: Yen, KE
author: Liau, LM
author: Jin, S
db: Pubmed
title: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
source: Nature 462:739-44
year: 2009

UnificationXref3241
type: UnificationXref
id: 197277
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197277

UnificationXref3242
type: UnificationXref
id: REACT_11937
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11937.2

UnificationXref3243
type: UnificationXref
id: CHEBI:15940
db: ChEBI

UnificationXref3244
type: UnificationXref
id: 197230
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197230

UnificationXref3245
type: UnificationXref
id: REACT_11564
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11564.2

UnificationXref3246
type: UnificationXref
id: P21369
db: UniProt

UnificationXref3247
type: UnificationXref
id: 197272
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197272

UnificationXref3248
type: UnificationXref
id: REACT_11253
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11253.1

UnificationXref3249
type: UnificationXref
id: 197190
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197190

UniProt:P0A8K1
type: ProteinReference
xref: UnificationXref2182
organism: BioSource1

Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction159
pathway component: BiochemicalReaction158
evidence: Evidence299
xref: UnificationXref1903
xref: RelationshipXref242
xref: UnificationXref1902
pathway order: PathwayStep284
pathway order: PathwayStep285
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3230
type: UnificationXref
id: REACT_11294
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11294.1

UnificationXref3231
type: UnificationXref
id: P30011
db: UniProt

Synthesis of Leukotrienes (LT) and Eoxins (EX)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction192
pathway component: BiochemicalReaction190
pathway component: BiochemicalReaction191
evidence: Evidence365
xref: RelationshipXref309
xref: UnificationXref2337
xref: UnificationXref2338
pathway order: PathwayStep350
pathway order: PathwayStep351
pathway order: PathwayStep349
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3238
type: UnificationXref
id: 4232268
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232268

UnificationXref3239
type: UnificationXref
id: REACT_106904
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106904.9

UnificationXref3236
type: UnificationXref
id: 4232265
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232265

UnificationXref3237
type: UnificationXref
id: 4232266
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232266

UnificationXref3234
type: UnificationXref
id: REACT_91028
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91028.9

UnificationXref3235
type: UnificationXref
id: P0A7B3
db: UniProt

UnificationXref3232
type: UnificationXref
id: 4232271
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232271

UnificationXref3233
type: UnificationXref
id: 4232273
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232273

UniProt:P0A8L1
type: ProteinReference
xref: UnificationXref946
organism: BioSource1

geldanamycin [ChEBI:5292]
type: SmallMoleculeReference
name: geldanamycin
xref: UnificationXref1258

http://identifiers.org/pubmed/4726295
type: PublicationXref
id: 4726295
author: Kelley, WN
author: Wyngaarden, JB
author: Holmes, EW
db: Pubmed
title: Human glutamine phosphoribosylpyrophosphate amidotransferase. Two molecular forms interconvertible by purine ribonucleotides and phosphoribosylpyrophosphate
source: J Biol Chem 248:6035-6040
year: 1973

http://identifiers.org/pubmed/8571957
type: PublicationXref
id: 8571957
author: Zingg, BC
author: Mohrenweiser, HW
author: Watanabe, M
db: Pubmed
title: Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus
source: Am J Hum Genet 58:308-16
year: 1996

nucleoplasm
type: CellularLocationVocabulary
xref: UnificationXref263

UnificationXref3220
type: UnificationXref
id: 4233306
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233306

http://identifiers.org/pubmed/19935667
type: PublicationXref
id: 19935667
author: Hall, RA
author: Ritter, SL
db: Pubmed
title: Fine-tuning of GPCR activity by receptor-interacting proteins
source: Nat Rev Mol Cell Biol 10:819-30
year: 2009

UnificationXref3225
type: UnificationXref
id: CHEBI:46828
db: ChEBI

UnificationXref3226
type: UnificationXref
id: 197238
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197238

UnificationXref3227
type: UnificationXref
id: REACT_11734
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11734.2

UnificationXref3228
type: UnificationXref
id: CHEBI:15763
db: ChEBI

UnificationXref3221
type: UnificationXref
id: 4233308
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233308

UnificationXref3222
type: UnificationXref
id: REACT_168760
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_168760.1

UnificationXref3223
type: UnificationXref
id: 4233551
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233551

UnificationXref3224
type: UnificationXref
id: REACT_168872
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_168872.1

UniProt:P0A8M0
type: ProteinReference
xref: UnificationXref845
organism: BioSource1

http://identifiers.org/pubmed/11988738
type: PublicationXref
id: 11988738
author: Lukas, J
author: Jackson, PK
author: Reimann, JD
author: Sorensen, CS
author: Hsu, JY
db: Pubmed
title: E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
source: Nat Cell Biol 4:358-66
year: 2002

UnificationXref3229
type: UnificationXref
id: 197220
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197220

http://identifiers.org/pubmed/12626323
type: PublicationXref
id: 12626323
author: Jiang, G
author: Zhang, BB
db: Pubmed
title: Glucagon and regulation of glucose metabolism
source: Am J Physiol Endocrinol Metab 284:E671-8
year: 2003

http://identifiers.org/pubmed/19172412
type: PublicationXref
id: 19172412
author: Wu, Y
author: Jakobs, C
author: Gibson, KM
author: Pearl, PL
author: Pettiford, JM
author: Knerr, I
author: Theodore, WH
author: Forester, K
author: Carter Snead O, 3rd
author: Cortez, MA
db: Pubmed
title: Succinic semialdehyde dehydrogenase deficiency: lessons from mice and men
source: J Inherit Metab Dis 32:343-52
year: 2009

UniProt:P43676
type: ProteinReference
xref: UnificationXref430
organism: BioSource1

Pb++
type: SmallMolecule
entity reference: CHEBI:27889
data source: Provenance1
xref: UnificationXref3708
xref: UnificationXref3707
cellular location: GO:0005759
comment: Reactome DB_ID: 391232
display name: Pb2+

UnificationXref3299
type: UnificationXref
id: REACT_11343
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11343.2

FPP
type: SmallMolecule
entity reference: CHEBI:17407
data source: Provenance1
xref: UnificationXref3710
xref: UnificationXref3711
cellular location: GO:0005759
comment: Reactome DB_ID: 2162257

UnificationXref3298
type: UnificationXref
id: 200739
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=200739

iron (ferrous)
type: SmallMolecule
entity reference: CHEBI:18248
data source: Provenance1
name: Fe(II)
xref: UnificationXref3697
xref: UnificationXref3696
cellular location: GO:0005759
comment: Reactome DB_ID: 113531
display name: Fe2+

protoheme
type: SmallMolecule
entity reference: Protoheme
data source: Provenance1
xref: UnificationXref3698
xref: UnificationXref3699
cellular location: GO:0005759
comment: Reactome DB_ID: 189444
display name: heme

Hydrogen peroxide
type: SmallMolecule
entity reference: CHEBI:16240
data source: Provenance1
xref: UnificationXref3687
xref: UnificationXref3686
cellular location: GO:0005758
comment: Reactome DB_ID: 189481
display name: H2O2

Protoporphyrin IX
type: SmallMolecule
entity reference: Protoporphyrin [ChEBI:8592]
data source: Provenance1
xref: UnificationXref3695
xref: UnificationXref3694
cellular location: GO:0005759
comment: Reactome DB_ID: 189487
display name: PRIN9

http://identifiers.org/pubmed/7968268
type: PublicationXref
id: 7968268
author: Hatch, GM
author: Cao, SG
db: Pubmed
title: Stimulation of phosphatidylglycerolphosphate phosphatase activity by unsaturated fatty acids in rat heart
source: Lipids 29:475-80
year: 1994

UnificationXref3293
type: UnificationXref
id: 200640
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=200640

UnificationXref3292
type: UnificationXref
id: CHEBI:65049
db: ChEBI

UnificationXref3291
type: UnificationXref
id: REACT_156534
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156534.3

UnificationXref3290
type: UnificationXref
id: 4232304
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232304

UnificationXref3297
type: UnificationXref
id: CHEBI:60473
db: ChEBI

UnificationXref3296
type: UnificationXref
id: REACT_156833
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156833.3

UnificationXref3295
type: UnificationXref
id: 4232294
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232294

UnificationXref3294
type: UnificationXref
id: REACT_11283
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11283.2

UniProt:P0A8F4
type: ProteinReference
xref: UnificationXref2981
organism: BioSource1

NAT1 substrate
type: SmallMolecule
data source: Provenance1
member physical entity: para-aminosalicylic acid
member physical entity: N-Hydroxy-4-aminobiphenyl
member physical entity: 4-aminobenzoate
member physical entity: Sulfanilamide
xref: UnificationXref3771
xref: UnificationXref3770
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 174969

UDP-glucuronic acid
type: SmallMolecule
entity reference: CHEBI:17200
data source: Provenance1
xref: UnificationXref3740
xref: UnificationXref3739
cellular location: GO:0005829
comment: Reactome DB_ID: 158601
display name: UDP-GlcA

Acetate
type: SmallMolecule
entity reference: CHEBI:15366
data source: Provenance1
name: Ethanoic acid
name: Acetic acid
xref: UnificationXref3730
xref: UnificationXref3729
cellular location: GO:0005829
comment: Reactome DB_ID: 29416
display name: CH3COO-

Acetate
type: SmallMolecule
entity reference: CHEBI:15366
data source: Provenance1
name: Ethanoic acid
name: Acetic acid
xref: UnificationXref3723
xref: UnificationXref3724
cellular location: GO:0005759
comment: Reactome DB_ID: 113539
display name: CH3COO-

heme O
type: SmallMolecule
entity reference: haem o
data source: Provenance1
xref: UnificationXref3714
xref: UnificationXref3713
cellular location: GO:0005759
comment: Reactome DB_ID: 2995328

NAT1 acetylated conjugate
type: SmallMolecule
data source: Provenance1
member physical entity: N-acetyl-p-aminosalicylate
member physical entity: N-hydroxy-4-aminobiphenyl O-acetylated conjugate
member physical entity: N-acetyl-p-aminobenzoate
member physical entity: N4-acetylsulfanilamide
xref: UnificationXref3784
xref: UnificationXref3785
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 174960

UnificationXref3288
type: UnificationXref
id: 4232289
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232289

UnificationXref3287
type: UnificationXref
id: P24186
db: UniProt

hexacosanoyl-CoA
type: SmallMoleculeReference
name: cerotoyl-coenzyme A
name: hexacosanoyl-coenzyme A
name: hexacosanoyl-CoA (N-C26:0CoA)
name: cerotoyl-CoA
name: C26:0-CoA
name: C26:0-coenzyme A
name: hexacosanoyl-CoA [ChEBI:52966]
xref: UnificationXref2092

UnificationXref3289
type: UnificationXref
id: 4232290
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232290

N-Hydroxy-4-aminobiphenyl
type: SmallMolecule
entity reference: N-Hydroxy-4-aminobiphenyl
data source: Provenance1
xref: UnificationXref3759
xref: UnificationXref3760
cellular location: GO:0005829
comment: Reactome DB_ID: 158847
display name: NHABP

4-aminobenzoate
type: SmallMolecule
entity reference: CHEBI:30753
data source: Provenance1
name: para-aminobenzoic acid
xref: UnificationXref3763
xref: UnificationXref3762
cellular location: GO:0005829
comment: Reactome DB_ID: 174970
display name: ABENZ

para-aminosalicylic acid
type: SmallMolecule
entity reference: 4-Aminosalicylate
data source: Provenance1
name: 4-aminosalicylate
xref: UnificationXref3765
xref: UnificationXref3766
cellular location: GO:0005829
comment: Reactome DB_ID: 174973
display name: ASAL

Sulfanilamide
type: SmallMolecule
entity reference: Sulfanilamide
data source: Provenance1
xref: UnificationXref3769
xref: UnificationXref3768
cellular location: GO:0005829
comment: Reactome DB_ID: 174965
display name: SAMD

UnificationXref3280
type: UnificationXref
id: 200679
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=200679

Pteroylglutamic acid
type: SmallMoleculeReference
name: Folate
name: Folic acid [ChEBI:5140]
name: Folic acid
xref: UnificationXref3255

UnificationXref3282
type: UnificationXref
id: 4232302
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232302

UnificationXref3281
type: UnificationXref
id: REACT_11336
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11336.2

UnificationXref3284
type: UnificationXref
id: CHEBI:28010
db: ChEBI

UnificationXref3283
type: UnificationXref
id: REACT_105205
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105205.9

UnificationXref3286
type: UnificationXref
id: REACT_4874
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4874.3

UnificationXref3285
type: UnificationXref
id: 111353
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111353

http://identifiers.org/pubmed/19006241
type: PublicationXref
id: 19006241
author: Häberle, J
author: Höhne, W
author: Engel, K
db: Pubmed
title: Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene
source: Hum Mutat 30:300-7
year: 2009

N4-acetylsulfanilamide
type: SmallMolecule
entity reference: CHEBI:63845
data source: Provenance1
xref: UnificationXref3782
xref: UnificationXref3783
cellular location: GO:0005829
comment: Reactome DB_ID: 174961

N-acetyl-p-aminosalicylate
type: SmallMolecule
entity reference: CHEBI:63817
data source: Provenance1
xref: UnificationXref3780
xref: UnificationXref3779
cellular location: GO:0005829
comment: Reactome DB_ID: 174957
display name: NAcPAS

Paraxanthine
type: SmallMolecule
entity reference: CHEBI:25858
data source: Provenance1
xref: UnificationXref3790
xref: UnificationXref3789
cellular location: GO:0005829
comment: Reactome DB_ID: 158687

NAT2 substrate
type: SmallMolecule
data source: Provenance1
member physical entity: Isoniazid
member physical entity: N-Hydroxy-4-aminobiphenyl
member physical entity: Paraxanthine
xref: UnificationXref3794
xref: UnificationXref3795
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 174971

N-acetyl-p-aminobenzoate
type: SmallMolecule
entity reference: CHEBI:63815
data source: Provenance1
xref: UnificationXref3777
xref: UnificationXref3776
cellular location: GO:0005829
comment: Reactome DB_ID: 174968
display name: NAcPAB

N-hydroxy-4-aminobiphenyl O-acetylated conjugate
type: SmallMolecule
entity reference: CHEBI:16395
data source: Provenance1
xref: UnificationXref3774
xref: UnificationXref3773
cellular location: GO:0005829
comment: Reactome DB_ID: 158853

5-acetylamino-6-formylamino-3-methyluracil
type: SmallMolecule
entity reference: 5-acetamido-6-formamido-3-methyluracil
data source: Provenance1
xref: UnificationXref3798
xref: UnificationXref3797
cellular location: GO:0005829
comment: Reactome DB_ID: 158676
display name: AFMU

N-acetylisoniazid
type: SmallMolecule
entity reference: CHEBI:7207
data source: Provenance1
xref: UnificationXref3800
xref: UnificationXref3801
cellular location: GO:0005829
comment: Reactome DB_ID: 159318
display name: NAcISNZ

Glutamate Neurotransmitter Release Cycle
type: Pathway
data source: Provenance1
pathway component: L-Glutamate uptake by neurons
pathway component: glutamine + H2O => glutamate + NH4+ [GLS]
evidence: Evidence173
xref: UnificationXref1179
xref: UnificationXref1178
xref: RelationshipXref134
pathway order: PathwayStep162
pathway order: PathwayStep161
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Isoniazid
type: SmallMolecule
entity reference: CHEBI:6030
data source: Provenance1
xref: UnificationXref3793
xref: UnificationXref3792
cellular location: GO:0005829
comment: Reactome DB_ID: 159316
display name: ISNZ

NAT2 acetylated conjugate
type: SmallMolecule
data source: Provenance1
member physical entity: 5-acetylamino-6-formylamino-3-methyluracil
member physical entity: N-hydroxy-4-aminobiphenyl O-acetylated conjugate
member physical entity: N-acetylisoniazid
xref: UnificationXref3802
xref: UnificationXref3803
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 174958

Dihydrothymine
type: SmallMoleculeReference
name: 5,6-Dihydrothymine
name: 5,6-Dihydrothymine [ChEBI:27468]
name: 5,6-Dihydro-5-methyluracil
xref: UnificationXref3025

UnificationXref3279
type: UnificationXref
id: REACT_11639
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11639.2

UnificationXref3278
type: UnificationXref
id: 200671
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=200671

(S)-3-Hydroxytetradecanoyl-CoA
type: SmallMoleculeReference
name: (S)-3-Hydroxytetradecanoyl-CoA [ChEBI:27466]
xref: UnificationXref1866

UnificationXref3277
type: UnificationXref
id: REACT_34227
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34227.10

UnificationXref3276
type: UnificationXref
id: 4232301
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232301

UnificationXref3275
type: UnificationXref
id: REACT_7545
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7545.3

UnificationXref3274
type: UnificationXref
id: 174404
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174404

UnificationXref3273
type: UnificationXref
id: CHEBI:63907
db: ChEBI

UnificationXref3272
type: UnificationXref
id: REACT_11451
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11451.2

UnificationXref3271
type: UnificationXref
id: 200665
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=200665

UnificationXref3270
type: UnificationXref
id: CHEBI:15641
db: ChEBI

http://identifiers.org/pubmed/16212990
type: PublicationXref
id: 16212990
author: Otis, TS
author: Dodson, PD
author: Meera, P
author: Karakossian, MH
db: Pubmed
title: Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons
source: Neuropharmacology 49:883-9
year: 2005

(S)-2-Amino-5-guanidinovaleric acid
type: SmallMolecule
entity reference: CHEBI:16467
data source: Provenance1
name: L-Arginine
xref: UnificationXref3810
xref: UnificationXref3811
cellular location: extracellular region
comment: Reactome DB_ID: 351977
display name: L-Arg

L-Amino Acids
type: SmallMolecule
data source: Provenance1
member physical entity: Glycine
member physical entity: L-2-amino-3-mercaptopropionic acid
member physical entity: SmallMolecule5
member physical entity: L-Methionine
member physical entity: L-Isoleucine
member physical entity: 2-Pyrrolidinecarboxylic acid
member physical entity: L-Asparagine
member physical entity: (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid
member physical entity: (S)-alpha-amino-beta-(3-indolyl)-propionic acid
member physical entity: 2-Amino-3-methylbutyric acid
member physical entity: L-Phenylalanine
member physical entity: (S)-2-Amino-5-guanidinovaleric acid
member physical entity: 2,6-diaminohexanoic acid
member physical entity: L-Threonine
member physical entity: SmallMolecule4
member physical entity: L-Leucine
member physical entity: (S)-alpha-Amino-1H-imidazole-4-propionic acid
member physical entity: L-serine
member physical entity: L-alpha-Alanine
member physical entity: L-Glutamine
xref: UnificationXref3840
xref: UnificationXref3839
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 428009

gamma-L-Glutamyl-L-cysteinyl-glycine
type: SmallMolecule
entity reference: gamma-L-Glutamyl-L-cysteinyl-glycine
data source: Provenance1
name: 5-L-Glutamyl-L-cysteinylglycine
name: N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine
name: Reduced glutathione
name: Glutathione
xref: UnificationXref3809
xref: UnificationXref3808
cellular location: extracellular region
comment: Reactome DB_ID: 1247892
display name: GSH

L-Leucine
type: SmallMolecule
entity reference: L-Leucine
data source: Provenance1
name: (2S)-alpha-2-Amino-4-methylvaleric acid
name: (2S)-alpha-Leucine
name: 2-amino-4-methylvaleric acid
xref: UnificationXref3819
xref: UnificationXref3820
cellular location: extracellular region
comment: Reactome DB_ID: 351964
display name: L-Leu

L-Isoleucine
type: SmallMolecule
entity reference: CHEBI:17191
data source: Provenance1
name: 2-Amino-3-methylvaleric acid
xref: UnificationXref3817
xref: UnificationXref3818
cellular location: extracellular region
comment: Reactome DB_ID: 352001
display name: L-Ile

(S)-alpha-Amino-1H-imidazole-4-propionic acid
type: SmallMolecule
entity reference: CHEBI:15971
data source: Provenance1
name: L-Histidine
xref: UnificationXref3816
xref: UnificationXref3815
cellular location: extracellular region
comment: Reactome DB_ID: 351970
display name: L-His

L-Asparagine
type: SmallMolecule
entity reference: CHEBI:17196
data source: Provenance1
name: 2-Aminosuccinamic acid
xref: UnificationXref3812
xref: UnificationXref3813
cellular location: extracellular region
comment: Reactome DB_ID: 351980
display name: L-Asn

2,6-diaminohexanoic acid
type: SmallMolecule
entity reference: 2,6-diaminohexanoic acid
data source: Provenance1
name: Lysine acid
name: L-Lysine
xref: UnificationXref3823
xref: UnificationXref3822
cellular location: extracellular region
comment: Reactome DB_ID: 351991
display name: L-Lys

L-Methionine
type: SmallMolecule
entity reference: L-2-Amino-4methylthiobutyric acid
data source: Provenance1
xref: UnificationXref3825
xref: UnificationXref3824
cellular location: extracellular region
comment: Reactome DB_ID: 351966
display name: L-Met

UnificationXref3269
type: UnificationXref
id: REACT_88455
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88455.9

L-Phenylalanine
type: SmallMolecule
entity reference: CHEBI:17295
data source: Provenance1
name: (S)-alpha-amino-beta-phenylpropionic acid
xref: UnificationXref3826
xref: UnificationXref3827
cellular location: extracellular region
comment: Reactome DB_ID: 351993
display name: L-Phe

UnificationXref3266
type: UnificationXref
id: P08192
db: UniProt

UnificationXref3265
type: UnificationXref
id: REACT_11817
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11817.2

UnificationXref3268
type: UnificationXref
id: 4232278
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232278

UnificationXref3267
type: UnificationXref
id: 4232276
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232276

UnificationXref3262
type: UnificationXref
id: REACT_114850
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114850.8

UnificationXref3261
type: UnificationXref
id: 4232285
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232285

UnificationXref3264
type: UnificationXref
id: 197969
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197969

UnificationXref3263
type: UnificationXref
id: CHEBI:28624
db: ChEBI

UnificationXref3260
type: UnificationXref
id: REACT_114371
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114371.8

(S)-alpha-amino-beta-(3-indolyl)-propionic acid
type: SmallMolecule
entity reference: L-Tryptophan [ChEBI:16828]
data source: Provenance1
name: L-Tryptophan
xref: UnificationXref3831
xref: UnificationXref3830
cellular location: extracellular region
comment: Reactome DB_ID: 352006
display name: L-Trp

2-Pyrrolidinecarboxylic acid
type: SmallMolecule
entity reference: CHEBI:17203
data source: Provenance1
name: L-Proline
xref: UnificationXref3828
xref: UnificationXref3829
cellular location: extracellular region
comment: Reactome DB_ID: 352033
display name: L-Pro

2-Amino-3-methylbutyric acid
type: SmallMolecule
entity reference: 2-Amino-3-methylbutyric acid
data source: Provenance1
name: L-Valine
xref: UnificationXref3836
xref: UnificationXref3835
cellular location: extracellular region
comment: Reactome DB_ID: 351992
display name: L-Val

(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid
type: SmallMolecule
entity reference: L-Tyrosine [ChEBI:17895]
data source: Provenance1
name: L-Tyrosine
name: (S)-3-(p-Hydroxyphenyl)alanine
xref: UnificationXref3832
xref: UnificationXref3833
cellular location: extracellular region
comment: Reactome DB_ID: 352030
display name: L-Tyr

gamma-glutamyl group
type: SmallMolecule
entity reference: CHEBI:24190
data source: Provenance1
xref: UnificationXref3842
xref: UnificationXref3843
cellular location: extracellular region
comment: Reactome DB_ID: 1247930

Glycine
type: SmallMolecule
entity reference: CHEBI:15428
data source: Provenance1
name: Aminoacetic acid
xref: UnificationXref3837
xref: UnificationXref3838
cellular location: extracellular region
comment: Reactome DB_ID: 266029
display name: Gly

Carbon dioxide
type: SmallMolecule
entity reference: CO2 [ChEBI:16526]
data source: Provenance1
xref: UnificationXref3861
xref: UnificationXref3860
cellular location: extracellular region
comment: Reactome DB_ID: 1237009
display name: CO2

cysteine-glycine
type: SmallMolecule
entity reference: Cys-Gly
data source: Provenance1
name: cysteinylglycine
xref: UnificationXref3847
xref: UnificationXref3848
cellular location: extracellular region
comment: Reactome DB_ID: 1247934
display name: Cys-Gly

Glyoxylate
type: SmallMolecule
entity reference: Glyoxylate
data source: Provenance1
xref: UnificationXref3562
xref: UnificationXref3563
cellular location: GO:0005782
comment: Reactome DB_ID: 389678

Glycolate
type: SmallMolecule
entity reference: CHEBI:17497
data source: Provenance1
xref: UnificationXref3565
xref: UnificationXref3566
cellular location: GO:0005782
comment: Reactome DB_ID: 389822

UniProt:P77730
type: ProteinReference
xref: UnificationXref3435
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A6T1
data source: Provenance1
name: P0A6T1
name: Phosphoglucose isomerase
name: NLK
name: PGI
name: SA-36
name: Sperm antigen-36
name: Neuroleukin
name: Glucose-6-phosphate isomerase
name: PHI
name: Phosphohexose isomerase
xref: UnificationXref1451
feature: FragmentFeature156
cellular location: intracellular
comment: Reactome DB_ID: 4231503
display name: GPI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P62601
data source: Provenance1
name: N-seryl-glycosylphosphatidylinositolethanolamine-TREH
name: P62601
name: trehalase
xref: UnificationXref1441
feature: FragmentFeature155
feature: ModificationFeature18
cellular location: plasma membrane
comment: Reactome DB_ID: 4232202
display name: TREH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A796
data source: Provenance1
name: PFK-C
name: Phosphohexokinase
name: Phosphofructokinase 1
name: 6-phosphofructokinase, isozyme C
name: Phosphofructo-1-kinase isozyme C
name: P0A796
name: 6-phosphofructokinase, type C
name: 6-phosphofructokinase, platelet type
name: K6PP_HUMAN
xref: UnificationXref1461
feature: FragmentFeature158
cellular location: intracellular
comment: Reactome DB_ID: 4231488
display name: PFKP

PFK-B
type: Protein
entity reference: P0A796
data source: Provenance1
name: 6-phosphofructokinase, liver type
name: Note: the coordinates are copied over from Homo sapiens.
name: Phosphohexokinase
name: Phosphofructokinase 1
name: Phosphofructo-1-kinase isozyme B
name: P0A796
xref: UnificationXref1459
feature: FragmentFeature157
cellular location: intracellular
comment: Reactome DB_ID: 4231486
display name: PFKL

UnificationXref1987
type: UnificationXref
id: 4231626
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231626

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0A858
data source: Provenance1
name: triosephosphate isomerase monomer
name: TPI1
name: TPIS_HUMAN
name: P0A858
name: Triosephosphate isomerase
xref: UnificationXref1487
feature: FragmentFeature159
cellular location: intracellular
comment: Reactome DB_ID: 4231480
display name: TIM

UnificationXref1986
type: UnificationXref
id: P27254
db: UniProt

UnificationXref1989
type: UnificationXref
id: CHEBI:18408
db: ChEBI

UnificationXref1988
type: UnificationXref
id: 4231627
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231627

UnificationXref1982
type: UnificationXref
id: REACT_153510
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153510.3

UnificationXref1983
type: UnificationXref
id: CHEBI:15465
db: ChEBI

UnificationXref1984
type: UnificationXref
id: 71009
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71009

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Provenance1
xref: UnificationXref3559
xref: UnificationXref3560
cellular location: GO:0005782
comment: Reactome DB_ID: 193465

UnificationXref1985
type: UnificationXref
id: REACT_5502
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5502.2

UnificationXref1980
type: UnificationXref
id: REACT_157791
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157791.3

http://identifiers.org/pubmed/6490615
type: PublicationXref
id: 6490615
author: Shimizu, T
author: Samuelsson, B
author: Rådmark, O
author: Jörnvall, H
db: Pubmed
title: Leukotriene A4 hydrolase in human leukocytes. Purification and properties
source: J Biol Chem 259:12339-45
year: 1984

UnificationXref1981
type: UnificationXref
id: 4233370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233370

Decarboxylated AdoMet
type: SmallMolecule
entity reference: (5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
data source: Provenance1
name: S-Adenosylmethioninamine
xref: UnificationXref3534
xref: UnificationXref3533
cellular location: GO:0005829
comment: Reactome DB_ID: 353113
display name: SAM

4-Trimethylammoniobutanoate
type: SmallMolecule
entity reference: CHEBI:16244
data source: Provenance1
xref: UnificationXref3523
xref: UnificationXref3524
cellular location: GO:0005829
comment: Reactome DB_ID: 31369
display name: TEABT

4-Trimethylammoniobutanal
type: SmallMolecule
entity reference: 4-Trimethylammoniobutanal
data source: Provenance1
xref: UnificationXref3520
xref: UnificationXref3521
cellular location: GO:0005829
comment: Reactome DB_ID: 31311
display name: TEABL

http://identifiers.org/pubmed/2960695
type: PublicationXref
id: 2960695
author: Danon, MJ
author: Harker, D
author: Spear, D
author: DiMauro, S
author: Vora, S
db: Pubmed
title: Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII.
source: J Clin Invest 80:1479-85
year: 1987

(S)-2-Amino-5-guanidinovaleric acid
type: SmallMolecule
entity reference: CHEBI:16467
data source: Provenance1
name: L-Arginine
xref: UnificationXref3510
xref: UnificationXref3511
cellular location: GO:0005829
comment: Reactome DB_ID: 29468
display name: L-Arg

http://identifiers.org/pubmed/7284378
type: PublicationXref
id: 7284378
author: Desgranges, C
author: Rabaud, M
author: Razaka, G
author: Bricaud, H
db: Pubmed
title: Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase
source: Biochim Biophys Acta 654:211-8
year: 1981

4-Methylthio-2-oxobutanoate (1-)
type: SmallMolecule
entity reference: 4-methylthio-2-oxobutanoate (1-)
data source: Provenance1
xref: UnificationXref3551
xref: UnificationXref3550
cellular location: GO:0005829
comment: Reactome DB_ID: 1237122

S-methylthio adenosine
type: SmallMolecule
entity reference: CHEBI:17509
data source: Provenance1
xref: UnificationXref3543
xref: UnificationXref3542
cellular location: GO:0005829
comment: Reactome DB_ID: 353106
display name: MTAD

Spermidine
type: SmallMolecule
entity reference: N-(3-Aminopropyl)-1,4-butane-diamine
data source: Provenance1
xref: UnificationXref3539
xref: UnificationXref3540
cellular location: GO:0005829
comment: Reactome DB_ID: 204635
display name: SPM

1,4-Butanediamine
type: SmallMolecule
entity reference: CHEBI:17148
data source: Provenance1
name: Tetramethylenediamine
name: 1,4-Diaminobutane
xref: UnificationXref3536
xref: UnificationXref3537
cellular location: GO:0005829
comment: Reactome DB_ID: 29610
display name: Putrescine

UnificationXref5
type: UnificationXref
id: CHEBI:29101
db: ChEBI

UnificationXref4
type: UnificationXref
id: REACT_13894
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13894.1

UnificationXref3
type: UnificationXref
id: 351626
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=351626

UnificationXref2
type: UnificationXref
id: CHEBI:15378
db: ChEBI

http://identifiers.org/pubmed/9564029
type: PublicationXref
id: 9564029
author: Kushner, JP
author: Phillips, JD
author: Hill, CP
author: Whitby, FG
db: Pubmed
title: Crystal structure of human uroporphyrinogen decarboxylase
source: EMBO J 17:2463-71
year: 1998

UnificationXref9
type: UnificationXref
id: 351973
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=351973

http://identifiers.org/pubmed/20430952
type: PublicationXref
id: 20430952
author: Pugh, Edward N
author: Burns, Marie E
db: Pubmed
title: Lessons from photoreceptors: turning off G-protein signaling in living cells
source: Physiology (Bethesda) 25:72-84
year: 2010

UnificationXref8
type: UnificationXref
id: CHEBI:17053
db: ChEBI

UnificationXref7
type: UnificationXref
id: REACT_4155
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4155.2

Fumarate
type: SmallMolecule
entity reference: ChEBI:37154 fumarate(1-)
data source: Provenance1
xref: UnificationXref3507
xref: UnificationXref3508
cellular location: GO:0005829
comment: Reactome DB_ID: 29586
display name: FUMA

UnificationXref6
type: UnificationXref
id: 74113
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74113

http://identifiers.org/pubmed/18202181
type: PublicationXref
id: 18202181
author: Hub, JS
author: de Groot, BL
db: Pubmed
title: Mechanism of selectivity in aquaporins and aquaglyceroporins
source: Proc Natl Acad Sci U S A 105:1198-203
year: 2008

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A6J1
data source: Provenance1
name: P0A6J1
name: Bifunctional PAPS synthethase 1
xref: UnificationXref1317
feature: FragmentFeature149
cellular location: intracellular
comment: Reactome DB_ID: 4232175
display name: PAPSS1

Bifunctional PAPS synthetases 1,2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1319
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232177
display name: PAPSS1,2

Zinc 2+
type: SmallMolecule
entity reference: CHEBI:29105
data source: Provenance1
xref: UnificationXref544
xref: UnificationXref543
cellular location: GO:0034774
comment: Reactome DB_ID: 216785
display name: Zn2+

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P05804
data source: Provenance1
name: Beta-glucuronidase
name: BGLR_HUMAN
name: P05804
xref: UnificationXref1294
feature: FragmentFeature148
cellular location: intracellular
comment: Reactome DB_ID: 4233154
display name: GUSB

http://identifiers.org/pubmed/4218100
type: PublicationXref
id: 4218100
author: Matalon, R
author: Brandt, IK
author: Dorfman, A
author: Justice, P
author: Arbogast, B
db: Pubmed
title: Morquio's syndrome: deficiency of a chondroitin sulfate N-acetylhexosamine sulfate sulfatase
source: Biochem Biophys Res Commun 61:759-65
year: 1974

ligands of SLC28A1
type: SmallMolecule
data source: Provenance1
member physical entity: Adenosine
member physical entity: cytidine
member physical entity: 2'-deoxyadenosine
member physical entity: uridine
member physical entity: thymidine
xref: UnificationXref571
xref: UnificationXref572
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 179738

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P76341
data source: Provenance1
name: TTHY_HUMAN
name: Transthyretin
name: P76341
xref: UnificationXref1277
feature: FragmentFeature147
cellular location: extracellular region
comment: Reactome DB_ID: 4232926
display name: TTR

UnificationXref1
type: UnificationXref
id: GO:0005576
db: GENE ONTOLOGY

UnificationXref1999
type: UnificationXref
id: 4231633
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231633

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P31447
data source: Provenance1
name: P31447
name: GNS_HUMAN
name: N-acetylglucosamine-6-sulfatase
name: OxA-GNS
name: active GNS
xref: UnificationXref1348
feature: FragmentFeature151
feature: ModificationFeature14
cellular location: intracellular
comment: Reactome DB_ID: 4233149
display name: GNS

UnificationXref1998
type: UnificationXref
id: REACT_2852
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2852.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A6J1
data source: Provenance1
name: PAPS2_HUMAN
name: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
name: P0A6J1
xref: UnificationXref1318
feature: FragmentFeature150
cellular location: intracellular
comment: Reactome DB_ID: 4232176
display name: PAPSS2

UnificationXref1997
type: UnificationXref
id: 70958
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70958

http://identifiers.org/pubmed/17374385
type: PublicationXref
id: 17374385
author: Murgia, C
author: Devirgiliis, C
author: Perozzi, G
author: Zalewski, PD
db: Pubmed
title: Zinc fluxes and zinc transporter genes in chronic diseases
source: Mutat Res 622:84-93
year: 2007

ligands of SLC28A1
type: SmallMolecule
data source: Provenance1
member physical entity: SmallMolecule102
member physical entity: adenosine
member physical entity: SmallMolecule100
member physical entity: SmallMolecule101
member physical entity: 2'-deoxyadenosine
xref: UnificationXref583
xref: UnificationXref584
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 179739

UnificationXref1995
type: UnificationXref
id: 4231632
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231632

uridine
type: SmallMolecule
entity reference: Uridine [ChEBI:16704]
data source: Provenance1
xref: UnificationXref570
xref: UnificationXref569
cellular location: extracellular region
comment: Reactome DB_ID: 83923
display name: Ura-Rib

Homologues of OxA-ARSB
type: Protein
data source: Provenance1
member physical entity: P25549
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1383
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4233027

UnificationXref1996
type: UnificationXref
id: CHEBI:15380
db: ChEBI

adenosine
type: SmallMolecule
entity reference: CHEBI:16335
data source: Provenance1
name: ADENOCARD (TN)
xref: UnificationXref575
xref: UnificationXref576
cellular location: GO:0005829
comment: Reactome DB_ID: 83909
display name: Ade-Rib

UnificationXref1993
type: UnificationXref
id: 4231630
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231630

2'-deoxyadenosine
type: SmallMolecule
entity reference: CHEBI:17256
data source: Provenance1
name: deoxyadenosine
xref: UnificationXref573
xref: UnificationXref574
cellular location: GO:0005829
comment: Reactome DB_ID: 83925
display name: dA

UnificationXref1994
type: UnificationXref
id: 4231631
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231631

Adenosine
type: SmallMolecule
entity reference: CHEBI:16335
data source: Provenance1
xref: UnificationXref560
xref: UnificationXref561
cellular location: extracellular region
comment: Reactome DB_ID: 83908
display name: Ade-Rib

Homologues of N-seryl-glycosylphosphatidylinositolethanolamine-TREH
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1442
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232203

UnificationXref1991
type: UnificationXref
id: REACT_161218
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161218.1

2'-deoxyadenosine
type: SmallMolecule
entity reference: CHEBI:17256
data source: Provenance1
name: deoxyadenosine
xref: UnificationXref558
xref: UnificationXref557
cellular location: extracellular region
comment: Reactome DB_ID: 83919
display name: dA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P13482
data source: Provenance1
name: P13482
name: N-seryl-glycosylphosphatidylinositolethanolamine-TREH
name: trehalase
xref: UnificationXref1439
feature: FragmentFeature154
feature: ModificationFeature17
cellular location: plasma membrane
comment: Reactome DB_ID: 4232198
display name: TREH

UnificationXref1992
type: UnificationXref
id: P27253
db: UniProt

thymidine
type: SmallMolecule
entity reference: Deoxythymidine
data source: Provenance1
name: 2'-deoxythymidine
xref: UnificationXref567
xref: UnificationXref566
cellular location: extracellular region
comment: Reactome DB_ID: 83922
display name: Thy-dRib

P25549
type: Protein
entity reference: UniProt:P25549
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ARSB_HUMAN
name: active ARSB
name: Arylsulfatase B
name: OxA-ARSB
xref: UnificationXref1380
feature: ModificationFeature15
feature: FragmentFeature152
cellular location: intracellular
comment: Reactome DB_ID: 4233022
display name: ARSB

cytidine
type: SmallMolecule
entity reference: CHEBI:17562
data source: Provenance1
xref: UnificationXref564
xref: UnificationXref563
cellular location: extracellular region
comment: Reactome DB_ID: 83948
display name: Cyt-Rib

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P77318
data source: Provenance1
name: ARSB_HUMAN
name: active ARSB
name: Arylsulfatase B
name: P77318
name: OxA-ARSB
xref: UnificationXref1382
feature: ModificationFeature16
feature: FragmentFeature153
cellular location: intracellular
comment: Reactome DB_ID: 4233026
display name: ARSB

UnificationXref1990
type: UnificationXref
id: 3159297
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3159297

Alpha-oxidation of phytanate
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction173
evidence: Evidence326
xref: UnificationXref2076
xref: RelationshipXref261
xref: UnificationXref2075
pathway order: PathwayStep312
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Protoporphyrinogen IX
type: SmallMolecule
entity reference: Protoporphyrinogen IX [ChEBI:8593]
data source: Provenance1
xref: UnificationXref3683
xref: UnificationXref3682
cellular location: GO:0005758
comment: Reactome DB_ID: 189478
display name: PPGEN9

Carbon dioxide
type: SmallMolecule
entity reference: CO2 [ChEBI:16526]
data source: Provenance1
xref: UnificationXref3685
xref: UnificationXref3684
cellular location: GO:0005758
comment: Reactome DB_ID: 189480
display name: CO2

Oxygen
type: SmallMolecule
entity reference: CHEBI:15379
data source: Provenance1
xref: UnificationXref3677
xref: UnificationXref3678
cellular location: GO:0005758
comment: Reactome DB_ID: 189461
display name: O2

Coproporphyrinogen III
type: SmallMolecule
entity reference: Coproporphyrinogen III [ChEBI:3880]
data source: Provenance1
xref: UnificationXref3680
xref: UnificationXref3679
cellular location: GO:0005758
comment: Reactome DB_ID: 189411
display name: COPRO3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0ABQ4
data source: Provenance1
name: Dihydrofolate reductase
name: DYR_HUMAN
name: P0ABQ4
xref: UnificationXref1227
feature: FragmentFeature142
cellular location: intracellular
comment: Reactome DB_ID: 4232281
display name: DHFR

UnificationXref1965
type: UnificationXref
id: REACT_105444
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105444.9

Succinate-semialdehyde dehydrogenase, mitochondrial
type: Protein
entity reference: UniProt:P25526
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ALDH5A1
name: SSDH_HUMAN
xref: UnificationXref1207
feature: FragmentFeature141
cellular location: intracellular
comment: Reactome DB_ID: 4232782
display name: P25526

UnificationXref1964
type: UnificationXref
id: 4231994
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231994

UnificationXref1967
type: UnificationXref
id: REACT_86279
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86279.9

Homologues of RRM2
type: Protein
data source: Provenance1
member physical entity: Ribonucleotide reductase small chain
xref: UnificationXref1232
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232120

UnificationXref1966
type: UnificationXref
id: 4233366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233366

UnificationXref3190
type: UnificationXref
id: 4232914
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232914

P77454
type: Protein
entity reference: P77454
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Glutaminase, liver isoform, mitochondrial precursor
name: glutaminase 2
xref: UnificationXref1168
feature: FragmentFeature138
cellular location: intracellular
comment: Reactome DB_ID: 4231583
display name: GLS2

UnificationXref1969
type: UnificationXref
id: REACT_105024
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105024.9

Homologues of GLS2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P77454
xref: UnificationXref1170
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231585

UnificationXref1968
type: UnificationXref
id: 4233363
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233363

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P23893
data source: Provenance1
name: 4-aminobutyrate aminotransferase, mitochondrial
name: P23893
name: GABT_HUMAN
xref: UnificationXref1193
feature: FragmentFeature140
cellular location: intracellular
comment: Reactome DB_ID: 4232849
display name: ABAT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A6W0
data source: Provenance1
name: Glutaminase, liver isoform, mitochondrial precursor
name: P0A6W0
name: glutaminase 2
xref: UnificationXref1169
feature: FragmentFeature139
cellular location: intracellular
comment: Reactome DB_ID: 4231584
display name: GLS2

UnificationXref3182
type: UnificationXref
id: 4232916
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232916

Ribonucleotide reductase small chain
type: Protein
entity reference: UniProt:P37146
data source: Provenance1
name: Ribonucleoside-diphosphate reductase M2 chain (EC 1.17.4.1) (Ribonucleotide reductase small chain)
name: Note: the coordinates are copied over from Homo sapiens.
name: Ribonucleoside-diphosphate reductase M2 chain
name: ribonucleotide reductase M2 polypeptide
name: P37146
xref: UnificationXref1229
feature: FragmentFeature143
cellular location: intracellular
comment: Reactome DB_ID: 4232116
display name: RRM2

UnificationXref3183
type: UnificationXref
id: REACT_147415
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147415.5

Ribonucleotide reductase small chain
type: Protein
entity reference: UniProt:P69924
data source: Provenance1
name: Ribonucleoside-diphosphate reductase M2 chain (EC 1.17.4.1) (Ribonucleotide reductase small chain)
name: Note: the coordinates are copied over from Homo sapiens.
name: P69924
name: Ribonucleoside-diphosphate reductase M2 chain
name: ribonucleotide reductase M2 polypeptide
xref: UnificationXref1231
feature: FragmentFeature144
cellular location: intracellular
comment: Reactome DB_ID: 4232119
display name: RRM2

UnificationXref3180
type: UnificationXref
id: 4232911
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232911

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0A884
data source: Provenance1
name: TYMS
name: TSase
name: P0A884
name: Thymidylate synthase
xref: UnificationXref1234
feature: FragmentFeature145
cellular location: intracellular
comment: Reactome DB_ID: 4231811
display name: TS

UnificationXref3181
type: UnificationXref
id: 4232912
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232912

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A6Z3
data source: Provenance1
name: P0A6Z3
name: HSP90AA1
xref: UnificationXref1250
feature: FragmentFeature146
cellular location: intracellular
comment: Reactome DB_ID: 4232309
display name: HSP90

UnificationXref3186
type: UnificationXref
id: REACT_26830
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26830.2

UnificationXref1960
type: UnificationXref
id: REACT_5111
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5111.1

UnificationXref3187
type: UnificationXref
id: CHEBI:18335
db: ChEBI

UnificationXref1961
type: UnificationXref
id: CHEBI:15453
db: ChEBI

UnificationXref3184
type: UnificationXref
id: CHEBI:16410
db: ChEBI

UnificationXref1962
type: UnificationXref
id: 77251
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77251

UnificationXref3185
type: UnificationXref
id: 964945
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964945

UnificationXref1963
type: UnificationXref
id: REACT_4099
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4099.2

Coproporphyrinogen I
type: SmallMolecule
entity reference: Coproporphyrinogen I
data source: Provenance1
xref: UnificationXref3673
xref: UnificationXref3672
cellular location: GO:0005829
comment: Reactome DB_ID: 190128
display name: COPRO1

Uroporphyrinogen I
type: SmallMolecule
entity reference: Uroporphyrinogen I
data source: Provenance1
xref: UnificationXref3670
xref: UnificationXref3669
cellular location: GO:0005829
comment: Reactome DB_ID: 190157
display name: URO1

UnificationXref3188
type: UnificationXref
id: 965146
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=965146

http://identifiers.org/pubmed/18403674
type: PublicationXref
id: 18403674
author: Steele, C
author: Mossman, BT
author: Dostert, C
author: Tschopp, J
author: Van Bruggen, R
author: Pétrilli, V
db: Pubmed
title: Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
source: Science 320:674-7
year: 2008

Coproporphyrinogen III
type: SmallMolecule
entity reference: Coproporphyrinogen III [ChEBI:3880]
data source: Provenance1
xref: UnificationXref3661
xref: UnificationXref3662
cellular location: GO:0005829
comment: Reactome DB_ID: 189455
display name: COPRO3

UnificationXref3189
type: UnificationXref
id: REACT_26021
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26021.2

Uroporphyrinogen III
type: SmallMolecule
entity reference: Uroporphyrinogen III [ChEBI:9905]
data source: Provenance1
xref: UnificationXref3659
xref: UnificationXref3658
cellular location: GO:0005829
comment: Reactome DB_ID: 189407
display name: URO3

dipyrromethane
type: SmallMolecule
entity reference: CHEBI:36319
data source: Provenance1
xref: UnificationXref3650
xref: UnificationXref3651
cellular location: GO:0005829
comment: Reactome DB_ID: 189447
display name: DIPY

Hydroxymethylbilane
type: SmallMolecule
entity reference: Hydroxymethylbilane [ChEBI:5809]
data source: Provenance1
name: preuroporphyrinogen
xref: UnificationXref3648
xref: UnificationXref3647
cellular location: GO:0005829
comment: Reactome DB_ID: 189449
display name: HMBL

Porphobilinogen
type: SmallMolecule
entity reference: CHEBI:17381
data source: Provenance1
xref: UnificationXref3643
xref: UnificationXref3642
cellular location: GO:0005829
comment: Reactome DB_ID: 189464
display name: PBG

L-Lanthionine
type: SmallMolecule
entity reference: CHEBI:21347
data source: Provenance1
xref: UnificationXref3618
xref: UnificationXref3619
cellular location: GO:0005829
comment: Reactome DB_ID: 1614582

Pb++
type: SmallMolecule
entity reference: CHEBI:27889
data source: Provenance1
xref: UnificationXref3630
xref: UnificationXref3631
cellular location: GO:0005829
comment: Reactome DB_ID: 190173
display name: Pb2+

delta-Aminolevulinic acid
type: SmallMolecule
entity reference: CHEBI:17549
data source: Provenance1
name: 5-aminolevulinate
xref: UnificationXref3640
xref: UnificationXref3639
cellular location: GO:0005829
comment: Reactome DB_ID: 189489
display name: dALA

http://identifiers.org/pubmed/8687421
type: PublicationXref
id: 8687421
author: Ishihara, H
author: Matsutani, A
author: Takeuchi, Y
author: Oka, Y
author: Kuwano, S
db: Pubmed
title: Molecular cloning of human mitochondrial glycerophosphate dehydrogenase gene: genomic structure, chromosomal localization, and existence of a pseudogene
source: Biochem Biophys Res Commun 223:481-6
year: 1996

UniProt:P0A836
type: ProteinReference
xref: UnificationXref2590
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AFP4
data source: Provenance1
name: HSD17B1
name: Estradiol 17-beta-dehydrogenase 1
xref: UnificationXref1149
feature: FragmentFeature135
cellular location: intracellular
comment: Reactome DB_ID: 4232757
display name: P0AFP4

UnificationXref1978
type: UnificationXref
id: 4232011
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232011

P22106
type: Protein
entity reference: UniProt:P22106
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Glutamine- dependent asparagine synthetase
name: TS11 cell cycle control protein
name: ASNS(2-561)
name: Asparagine synthetase (glutamine-hydrolyzing)
xref: UnificationXref1132
feature: FragmentFeature134
cellular location: intracellular
comment: Reactome DB_ID: 4231571
display name: ASNS

UnificationXref1977
type: UnificationXref
id: 4232010
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232010

P36659
type: Protein
entity reference: P36659
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DNAJB9
name: ERdj4
xref: UnificationXref1124
feature: FragmentFeature133
cellular location: intracellular
comment: Reactome DB_ID: 4233162
display name: MDG1

UnificationXref1976
type: UnificationXref
id: P0AET8
db: UniProt

Endoplasmin
type: Protein
entity reference: P0A6Z3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ENPL_HUMAN
name: HSP90B1
xref: UnificationXref1116
feature: FragmentFeature132
cellular location: intracellular
comment: Reactome DB_ID: 4233164
display name: P0A6Z3

UnificationXref1975
type: UnificationXref
id: REACT_3172
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3172.1

MUC21_HUMAN
type: Protein
entity reference: P77515
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P77515
name: Core 8 (MUC21)
xref: UnificationXref1107
feature: FragmentFeature131
feature: ModificationFeature13
cellular location: intracellular
comment: Reactome DB_ID: 4232812
display name: MUC21

MUC21_HUMAN
type: Protein
entity reference: P76072
data source: Provenance1
name: P76072
name: Note: the coordinates are copied over from Homo sapiens.
name: Core 8 (MUC21)
xref: UnificationXref1106
feature: ModificationFeature12
feature: FragmentFeature130
cellular location: intracellular
comment: Reactome DB_ID: 4232810
display name: MUC21

(R)-2-hydroxyglutaric acid
type: SmallMoleculeReference
name: (R)-2-Hydroxyglutarate
name: ChEBI:32796 (R)-2-hydroxyglutaric acid
xref: UnificationXref2610

Homologues of Core 8 (MUC21)
type: Protein
data source: Provenance1
member physical entity: MUC21_HUMAN
xref: UnificationXref1108
cellular location: intracellular
comment: Reactome DB_ID: 4232813
comment: Converted from EntitySet in Reactome

ChEBI:32797 (S)-2-Hydroxyglutarate
type: SmallMoleculeReference
name: (S)-2-Hydroxyglutarate
xref: UnificationXref2603

MUC21_HUMAN
type: Protein
entity reference: P77515
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P77515
name: Core 7 (MUC21)
xref: UnificationXref1099
feature: FragmentFeature129
feature: ModificationFeature11
cellular location: intracellular
comment: Reactome DB_ID: 4232839
display name: MUC21

UnificationXref1979
type: UnificationXref
id: 4232013
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232013

UnificationXref3191
type: UnificationXref
id: REACT_136967
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136967.5

P77454
type: Protein
entity reference: P77454
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Glutaminase, kidney isoform, mitochondrial precursor
name: glutaminase
xref: UnificationXref1163
feature: FragmentFeature136
cellular location: intracellular
comment: Reactome DB_ID: 4231577
display name: GLS

UnificationXref3192
type: UnificationXref
id: CHEBI:16709
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A6W0
data source: Provenance1
name: Glutaminase, kidney isoform, mitochondrial precursor
name: glutaminase
name: P0A6W0
xref: UnificationXref1165
feature: FragmentFeature137
cellular location: intracellular
comment: Reactome DB_ID: 4231580
display name: GLS

UnificationXref1970
type: UnificationXref
id: CHEBI:29119
db: ChEBI

http://identifiers.org/pubmed/3208766
type: PublicationXref
id: 3208766
author: Day, IN
author: Fothergill, JE
author: McAleese, SM
author: Hinks, LJ
author: Dunbar, B
db: Pubmed
title: Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE)
source: Eur J Biochem 178:413-7
year: 1988

UnificationXref3193
type: UnificationXref
id: 965053
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=965053

UnificationXref3194
type: UnificationXref
id: REACT_26765
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26765.2

Homologues of GLS
type: Protein
data source: Provenance1
member physical entity: P77454
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1166
cellular location: intracellular
comment: Reactome DB_ID: 4231581
comment: Converted from EntitySet in Reactome

UnificationXref3195
type: UnificationXref
id: CHEBI:28803
db: ChEBI

UnificationXref1973
type: UnificationXref
id: CHEBI:29126
db: ChEBI

UnificationXref3196
type: UnificationXref
id: 964952
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=964952

UnificationXref1974
type: UnificationXref
id: 109994
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109994

UnificationXref3197
type: UnificationXref
id: REACT_26668
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26668.2

UnificationXref1971
type: UnificationXref
id: 109990
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109990

UnificationXref3198
type: UnificationXref
id: 4232915
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232915

UnificationXref1972
type: UnificationXref
id: REACT_3866
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3866.1

Homocysteine
type: SmallMolecule
entity reference: CHEBI:17230
data source: Provenance1
xref: UnificationXref3602
xref: UnificationXref3603
cellular location: GO:0005829
comment: Reactome DB_ID: 174369
display name: HCYS

UnificationXref3199
type: UnificationXref
id: REACT_129633
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129633.5

http://identifiers.org/pubmed/7859077
type: PublicationXref
id: 7859077
author: Plaitakis, A
author: Shashidharan, P
author: Morrison, JH
author: Huntley, GW
author: Meyer, T
db: Pubmed
title: Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain
source: Brain Res 662:245-50
year: 1994

2-Ketobutyrate
type: SmallMolecule
entity reference: CHEBI:30831
data source: Provenance1
xref: UnificationXref3593
xref: UnificationXref3592
cellular location: GO:0005829
comment: Reactome DB_ID: 936714
display name: 2-oxobutanoate

L-Homolanthionine
type: SmallMolecule
entity reference: CHEBI:62856
data source: Provenance1
xref: UnificationXref3613
xref: UnificationXref3612
cellular location: GO:0005829
comment: Reactome DB_ID: 1614594

H2S
type: SmallMolecule
entity reference: CHEBI:16136
data source: Provenance1
xref: UnificationXref3606
xref: UnificationXref3605
cellular location: GO:0005829
comment: Reactome DB_ID: 1614532

Riboflavin-5-phosphate
type: SmallMolecule
entity reference: FMN [ChEBI:17621]
data source: Provenance1
name: Flavin mononucleotide
xref: UnificationXref3574
xref: UnificationXref3573
cellular location: GO:0005782
comment: Reactome DB_ID: 389864
display name: FMN

NADP+
type: SmallMolecule
entity reference: NADP+
data source: Provenance1
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref3568
xref: UnificationXref3567
cellular location: GO:0005782
comment: Reactome DB_ID: 389556
display name: TPN

L-Cystathionine
type: SmallMolecule
entity reference: CHEBI:17482
data source: Provenance1
xref: UnificationXref3589
xref: UnificationXref3590
cellular location: GO:0005829
comment: Reactome DB_ID: 1614518

Oxalate
type: SmallMolecule
entity reference: Ethanedioic acid
data source: Provenance1
xref: UnificationXref3583
xref: UnificationXref3582
cellular location: GO:0005782
comment: Reactome DB_ID: 389819
display name: OX

Homologues of GalNAc-MUC21
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1081
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232802

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P76072
data source: Provenance1
name: Tn antigen (MUC21)
name: GalNAc-MUC21
xref: UnificationXref1078
feature: ModificationFeature4
feature: FragmentFeature122
cellular location: intracellular
comment: Reactome DB_ID: 4232799
display name: P76072

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P77515
data source: Provenance1
name: Tn antigen (MUC21)
name: GalNAc-MUC21
xref: UnificationXref1080
feature: ModificationFeature5
feature: FragmentFeature123
cellular location: intracellular
comment: Reactome DB_ID: 4232801
display name: P77515

Homologues of Core 5 (MUC21)
type: Protein
data source: Provenance1
member physical entity: MUC21_HUMAN
xref: UnificationXref1084
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232807

MUC21_HUMAN
type: Protein
entity reference: P76072
data source: Provenance1
name: P76072
name: Note: the coordinates are copied over from Homo sapiens.
name: Core 5 (MUC21)
xref: UnificationXref1082
feature: ModificationFeature6
feature: FragmentFeature124
cellular location: intracellular
comment: Reactome DB_ID: 4232804
display name: MUC21

MUC21_HUMAN
type: Protein
entity reference: P77515
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P77515
name: Core 5 (MUC21)
xref: UnificationXref1083
feature: FragmentFeature125
feature: ModificationFeature7
cellular location: intracellular
comment: Reactome DB_ID: 4232806
display name: MUC21

Homologues of Core 6 (MUC21)
type: Protein
data source: Provenance1
member physical entity: MUC21_HUMAN
xref: UnificationXref1092
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232819

MUC21_HUMAN
type: Protein
entity reference: P76072
data source: Provenance1
name: P76072
name: Note: the coordinates are copied over from Homo sapiens.
name: Core 6 (MUC21)
xref: UnificationXref1090
feature: ModificationFeature8
feature: FragmentFeature126
cellular location: intracellular
comment: Reactome DB_ID: 4232816
display name: MUC21

MUC21_HUMAN
type: Protein
entity reference: P77515
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P77515
name: Core 6 (MUC21)
xref: UnificationXref1091
feature: ModificationFeature9
feature: FragmentFeature127
cellular location: intracellular
comment: Reactome DB_ID: 4232818
display name: MUC21

Pyrimidine catabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction253
pathway component: BiochemicalReaction252
pathway component: BiochemicalReaction256
pathway component: BiochemicalReaction257
pathway component: BiochemicalReaction254
pathway component: BiochemicalReaction255
evidence: Evidence457
xref: UnificationXref3036
xref: RelationshipXref426
xref: UnificationXref3035
pathway order: PathwayStep441
pathway order: PathwayStep440
pathway order: PathwayStep442
pathway order: PathwayStep439
pathway order: PathwayStep438
pathway order: PathwayStep443
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

MUC21_HUMAN
type: Protein
entity reference: P76072
data source: Provenance1
name: P76072
name: Note: the coordinates are copied over from Homo sapiens.
name: Core 7 (MUC21)
xref: UnificationXref1098
feature: ModificationFeature10
feature: FragmentFeature128
cellular location: intracellular
comment: Reactome DB_ID: 4232837
display name: MUC21

Homologues of Core 7 (MUC21)
type: Protein
data source: Provenance1
member physical entity: MUC21_HUMAN
xref: UnificationXref1100
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232840

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P00962
data source: Provenance1
name: Glutaminyl-tRNA synthetase
name: P00962
xref: UnificationXref883
feature: FragmentFeature115
cellular location: intracellular
comment: Reactome DB_ID: 4232440
display name: QARS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P00956
data source: Provenance1
name: Isoleucyl-tRNA synthetase 2
name: P00956
xref: UnificationXref896
feature: FragmentFeature116
cellular location: intracellular
comment: Reactome DB_ID: 4232393
display name: IARS2

http://identifiers.org/pubmed/8490623
type: PublicationXref
id: 8490623
author: Green, E P
author: Bentley, D R
author: Green, P M
author: Flomen, R H
author: Giannelli, F
db: Pubmed
title: Determination of the organisation of coding sequences within the iduronate sulphate sulphatase (IDS) gene
source: Hum. Mol. Genet. 2:5-10
year: 1993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P21889
data source: Provenance1
name: P21889
name: Aspartyl-tRNA synthetase 2
xref: UnificationXref858
feature: FragmentFeature113
cellular location: intracellular
comment: Reactome DB_ID: 4232428
display name: DARS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P27305
data source: Provenance1
name: P27305
name: Glutamyl-tRNA synthetase 2
xref: UnificationXref871
feature: FragmentFeature114
cellular location: intracellular
comment: Reactome DB_ID: 4232413
display name: EARS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P16659
data source: Provenance1
name: P16659
name: Prolyl-tRNA synthetase 2
xref: UnificationXref935
feature: FragmentFeature117
cellular location: intracellular
comment: Reactome DB_ID: 4232398
display name: PARS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0A8L1
data source: Provenance1
name: Seryl-tRNA synthetase 2
name: P0A8L1
xref: UnificationXref947
feature: FragmentFeature118
cellular location: intracellular
comment: Reactome DB_ID: 4232434
display name: SARS2

P07813
type: Protein
entity reference: UniProt:P07813
data source: Provenance1
xref: UnificationXref909
cellular location: intracellular
comment: Reactome DB_ID: 4232403

P08312
type: Protein
entity reference: P08312
data source: Provenance1
xref: UnificationXref922
cellular location: intracellular
comment: Reactome DB_ID: 4232408

P00954
type: Protein
entity reference: P00954
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Tryptophanyl-tRNA synthetase 2
xref: UnificationXref961
feature: FragmentFeature119
cellular location: intracellular
comment: Reactome DB_ID: 4232418
display name: WARS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AGJ9
data source: Provenance1
name: P0AGJ9
name: Tyrosyl-tRNA synthetase 2
xref: UnificationXref971
feature: FragmentFeature120
cellular location: intracellular
comment: Reactome DB_ID: 4232387
display name: YARS2

http://identifiers.org/pubmed/11891227
type: PublicationXref
id: 11891227
author: Mendel, RR
author: Schwarz, G
author: Hänzelmann, P
db: Pubmed
title: Functionality of alternative splice forms of the first enzymes involved in human molybdenum cofactor biosynthesis
source: J Biol Chem 277:18303-12
year: 2002

http://identifiers.org/pubmed/19530173
type: PublicationXref
id: 19530173
author: Oishi, Isao
author: Endo, Mitsuharu
author: Minami, Yasuhiro
author: Nishita, Michiru
db: Pubmed
title: Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases
source: Dev. Dyn. 239:1-15
year: 2010

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P00946
data source: Provenance1
name: MPI(2-423)
name: P00946
name: MPI_HUMAN
name: Mannose-6-phosphate isomerase
xref: UnificationXref1062
feature: FragmentFeature121
cellular location: intracellular
comment: Reactome DB_ID: 4232747
display name: MPI

http://identifiers.org/pubmed/15863030
type: PublicationXref
id: 15863030
author: Schlessinger, J
author: Eswarakumar, VP
author: Lax, I
db: Pubmed
title: Cellular signaling by fibroblast growth factor receptors
source: Cytokine Growth Factor Rev 16:139-49
year: 2005

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32703
data source: Provenance1
name: P32703
name: SL9C1_HUMAN
name: Sodium/hydrogen exchanger 10
xref: UnificationXref766
feature: FragmentFeature106
cellular location: intracellular
comment: Reactome DB_ID: 4233280
display name: SLC9C1

SASP
type: Protein
entity reference: UniProt:P0AGG4
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: ATL-derived factor
name: ADF
name: P0AGG4
name: Surface associated sulphydryl protein
xref: UnificationXref776
feature: FragmentFeature107
cellular location: intracellular
comment: Reactome DB_ID: 4231822
display name: TXN

SASP
type: Protein
entity reference: UniProt:P0AGG4
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: Thioredoxin, oxidized
name: ATL-derived factor
name: 2xHC-TXN
name: P0AGG4
name: Surface associated sulphydryl protein
xref: UnificationXref781
feature: ModificationFeature3
feature: ModificationFeature2
feature: FragmentFeature108
cellular location: intracellular
comment: Reactome DB_ID: 4231821
display name: ADF

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AGD1
data source: Provenance1
name: Superoxide dismutase (Cu-Zn)
name: P0AGD1
xref: UnificationXref795
feature: FragmentFeature109
cellular location: intracellular
comment: Reactome DB_ID: 4232702
display name: SOD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0AA76
data source: Provenance1
name: SLC17A3 isoform 2
name: NPT4_HUMAN
name: Sodium-dependent phosphate transport protein 4
name: SLC17A3(1-498)
name: SLC17A3-2
xref: UnificationXref755
feature: FragmentFeature103
cellular location: plasma membrane
comment: Reactome DB_ID: 4233284
display name: P0AA76

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q46916
data source: Provenance1
name: SLC17A3 isoform 2
name: NPT4_HUMAN
name: Sodium-dependent phosphate transport protein 4
name: SLC17A3(1-498)
name: SLC17A3-2
xref: UnificationXref756
feature: FragmentFeature104
cellular location: plasma membrane
comment: Reactome DB_ID: 4233285
display name: Q46916

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0AA80
data source: Provenance1
name: SLC17A3 isoform 2
name: NPT4_HUMAN
name: Sodium-dependent phosphate transport protein 4
name: SLC17A3(1-498)
name: SLC17A3-2
xref: UnificationXref757
feature: FragmentFeature105
cellular location: plasma membrane
comment: Reactome DB_ID: 4233286
display name: P0AA80

http://identifiers.org/pubmed/12512856
type: PublicationXref
id: 12512856
author: Silbert, JE
author: Sugumaran, G
db: Pubmed
title: Biosynthesis of chondroitin/dermatan sulfate
source: IUBMB Life 54:177-86
year: 2002

http://identifiers.org/pubmed/12512857
type: PublicationXref
id: 12512857
author: Funderburgh, JL
db: Pubmed
title: Keratan sulfate biosynthesis
source: IUBMB Life 54:187-94
year: 2002

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AGD1
data source: Provenance1
name: Superoxide dismutase (Cu-Zn)
name: P0AGD1
xref: UnificationXref796
feature: FragmentFeature110
cellular location: extracellular region
comment: Reactome DB_ID: 4232703
display name: SOD1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P42589
data source: Provenance1
name: P42589
name: Tyrosyl-tRNA synthetase
xref: UnificationXref823
feature: FragmentFeature111
cellular location: intracellular
comment: Reactome DB_ID: 4232381
display name: YARS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0A8M0
data source: Provenance1
name: P0A8M0
name: Asparaginyl-tRNA synthetase 2
xref: UnificationXref846
feature: FragmentFeature112
cellular location: intracellular
comment: Reactome DB_ID: 4232423
display name: NARS2

http://identifiers.org/pubmed/20810651
type: PublicationXref
id: 20810651
author: Kitamura, Kenichiro
author: Anzai, N
author: Yamanaka, Hisashi
author: Urano, Wako
author: Sakurai, Hiroyuki
author: Taniguchi, Atsuo
author: Jutabha, P
author: Fujita, T
author: Endou, H
author: Katada, Tomohisa
author: Kimura, Toru
author: Moriyama, Yoshinori
author: Seki, George
author: Yamada, Hideomi
author: Wempe, Michael F
author: Yamada, Akira
author: Tomita, Kimio
author: Kaneko, Shuji
author: Uchida, Shunya
author: Yan, Kunimasa
author: Shimada, Hidetaka
author: Fukutomi, Toshiyuki
db: Pubmed
title: Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate
source: J. Biol. Chem. 285:35123-32
year: 2010

UniProt:P04825
type: ProteinReference
xref: UnificationXref2311
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P39398
data source: Provenance1
name: SLC17A3
name: SLC17A3 isoform 1
name: NPT4_HUMAN
name: Sodium-dependent phosphate transport protein 4
name: SLC17A3-1
xref: UnificationXref742
feature: FragmentFeature98
cellular location: intracellular
comment: Reactome DB_ID: 4233290
display name: P39398

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0AA76
data source: Provenance1
name: SLC17A3
name: SLC17A3 isoform 1
name: NPT4_HUMAN
name: Sodium-dependent phosphate transport protein 4
name: SLC17A3-1
xref: UnificationXref743
feature: FragmentFeature99
cellular location: intracellular
comment: Reactome DB_ID: 4233291
display name: P0AA76

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P60844
data source: Provenance1
name: AQP6_HUMAN
name: Aquaporin-6
name: P60844
xref: UnificationXref690
feature: FragmentFeature97
cellular location: intracellular
comment: Reactome DB_ID: 4232628
display name: AQP6

Homologues of SLC17A3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref746
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4233294

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AER0
data source: Provenance1
name: Aquaporin-9
name: AQP9_HUMAN
name: P0AER0
xref: UnificationXref651
feature: FragmentFeature95
cellular location: plasma membrane
comment: Reactome DB_ID: 4232635
display name: AQP9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AER0
data source: Provenance1
name: Aquaporin-10
name: AQP10_HUMAN
name: P0AER0
xref: UnificationXref653
feature: FragmentFeature96
cellular location: plasma membrane
comment: Reactome DB_ID: 4232711
display name: AQP10

Homologues of SLC17A3(1-498)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref758
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4233287

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P39398
data source: Provenance1
name: SLC17A3 isoform 2
name: NPT4_HUMAN
name: Sodium-dependent phosphate transport protein 4
name: SLC17A3(1-498)
name: SLC17A3-2
xref: UnificationXref754
feature: FragmentFeature102
cellular location: plasma membrane
comment: Reactome DB_ID: 4233283
display name: P39398

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q46916
data source: Provenance1
name: SLC17A3
name: SLC17A3 isoform 1
name: NPT4_HUMAN
name: Sodium-dependent phosphate transport protein 4
name: SLC17A3-1
xref: UnificationXref744
feature: FragmentFeature100
cellular location: intracellular
comment: Reactome DB_ID: 4233292
display name: Q46916

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0AA80
data source: Provenance1
name: SLC17A3
name: SLC17A3 isoform 1
name: NPT4_HUMAN
name: Sodium-dependent phosphate transport protein 4
name: SLC17A3-1
xref: UnificationXref745
feature: FragmentFeature101
cellular location: intracellular
comment: Reactome DB_ID: 4233293
display name: P0AA80

http://identifiers.org/pubmed/19946895
type: PublicationXref
id: 19946895
author: Albers, E
db: Pubmed
title: Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine
source: IUBMB Life 61:1132-42
year: 2009

inorganic phosphate
type: SmallMolecule
entity reference: CHEBI:18367
data source: Provenance1
name: Orthophosphate
name: phosphate
xref: UnificationXref106
xref: UnificationXref105
cellular location: extracellular region
comment: Reactome DB_ID: 109277
display name: Pi

L-alpha-Alanine
type: SmallMolecule
entity reference: L-Alanine [ChEBI:16977]
data source: Provenance1
name: L-Alanine
name: L-2-Aminopropionic acid
xref: UnificationXref120
xref: UnificationXref119
cellular location: extracellular region
comment: Reactome DB_ID: 352036
display name: L-Ala

Phosphate
type: SmallMolecule
entity reference: CHEBI:18367
data source: Provenance1
name: Orthophosphate
name: Inorganic Phosphate
xref: UnificationXref107
xref: UnificationXref108
cellular location: GO:0005829
comment: Reactome DB_ID: 29372
display name: Pi

alanine, serine, threonine, or cysteine
type: SmallMolecule
data source: Provenance1
member physical entity: L-2-amino-3-mercaptopropionic acid
member physical entity: L-Threonine
member physical entity: L-serine
member physical entity: L-alpha-Alanine
xref: UnificationXref141
xref: UnificationXref140
cellular location: extracellular region
comment: Reactome DB_ID: 352359
comment: Converted from EntitySet in Reactome

L-2-amino-3-mercaptopropionic acid
type: SmallMolecule
entity reference: CHEBI:17561
data source: Provenance1
name: L-cysteine
xref: UnificationXref131
xref: UnificationXref130
cellular location: GO:0005829
comment: Reactome DB_ID: 111707
display name: Cys

L-serine
type: SmallMolecule
entity reference: CHEBI:17115
data source: Provenance1
xref: UnificationXref135
xref: UnificationXref134
cellular location: extracellular region
comment: Reactome DB_ID: 352002
display name: L-Ser

L-alpha-Alanine
type: SmallMolecule
entity reference: L-Alanine [ChEBI:16977]
data source: Provenance1
name: L-Alanine
name: L-2-Aminopropionic acid
xref: UnificationXref122
xref: UnificationXref121
cellular location: GO:0005829
comment: Reactome DB_ID: 29432
display name: L-Ala

alanine, serine, threonine, or cysteine
type: SmallMolecule
data source: Provenance1
member physical entity: L-2-amino-3-mercaptopropionic acid
member physical entity: L-serine
member physical entity: L-alpha-Alanine
member physical entity: L-Threonine
xref: UnificationXref133
xref: UnificationXref132
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 352355

L-Threonine
type: SmallMolecule
entity reference: L-Threonine
data source: Provenance1
xref: UnificationXref127
xref: UnificationXref128
cellular location: GO:0005829
comment: Reactome DB_ID: 351990
display name: L-Thr

L-serine
type: SmallMolecule
entity reference: CHEBI:17115
data source: Provenance1
xref: UnificationXref124
xref: UnificationXref125
cellular location: GO:0005829
comment: Reactome DB_ID: 200736
display name: L-Ser

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AER0
data source: Provenance1
name: AQP7_HUMAN
name: Aquaporin-7
name: P0AER0
xref: UnificationXref647
feature: FragmentFeature93
cellular location: plasma membrane
comment: Reactome DB_ID: 4232649
display name: AQP7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P60844
data source: Provenance1
name: AQP5_HUMAN
name: Aquaporin-5
name: P60844
xref: UnificationXref645
feature: FragmentFeature92
cellular location: plasma membrane
comment: Reactome DB_ID: 4232707
display name: AQP5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P60844
data source: Provenance1
name: Aquaporin-4
name: AQP4_HUMAN
name: P60844
xref: UnificationXref643
feature: FragmentFeature91
cellular location: plasma membrane
comment: Reactome DB_ID: 4232645
display name: AQP4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AER0
data source: Provenance1
name: Aquaporin-3
name: AQP3_HUMAN
name: P0AER0
xref: UnificationXref641
feature: FragmentFeature90
cellular location: plasma membrane
comment: Reactome DB_ID: 4232675
display name: AQP3

UnificationXref1909
type: UnificationXref
id: REACT_3098
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3098.1

http://identifiers.org/pubmed/16764946
type: PublicationXref
id: 16764946
author: Catalán, V
author: Frühbeck, G
author: Gómez-Ambrosi, J
author: Rodriguez, A
db: Pubmed
title: Aquaporin-7 and glycerol permeability as novel obesity drug-target pathways
source: Trends Pharmacol Sci 27:345-7
year: 2006

http://identifiers.org/pubmed/10484776
type: PublicationXref
id: 10484776
author: Lin, K
author: Milliner, DS
author: Ferree, PM
author: Holmes, RP
author: Cramer, SD
db: Pubmed
title: The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II
source: Hum Mol Genet 8:2063-9
year: 1999

UnificationXref1908
type: UnificationXref
id: 77341
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77341

UnificationXref1907
type: UnificationXref
id: CHEBI:28325
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P60844
data source: Provenance1
name: Aquaporin-8
name: AQP8_HUMAN
name: P60844
xref: UnificationXref649
feature: FragmentFeature94
cellular location: plasma membrane
comment: Reactome DB_ID: 4232709
display name: AQP8

UnificationXref1906
type: UnificationXref
id: REACT_3903
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3903.1

http://identifiers.org/pubmed/8644733
type: PublicationXref
id: 8644733
author: Romana, M
author: Moran-Jimenez, MJ
author: D'Alessandro, L
author: Topi, G
author: Enriquez De Salamanca, R
author: de Verneuil, H
author: Taieb, A
author: Ged, C
db: Pubmed
title: Uroporphyrinogen decarboxylase: complete human gene sequence and molecular study of three families with hepatoerythropoietic porphyria
source: Am J Hum Genet 58:712-21
year: 1996

CNT 2
type: Protein
entity reference: UniProt:P0AFF2
data source: Provenance1
name: SPNT
name: P0AFF2
name: Sodium/purine nucleoside co- transporter
name: Na(+)/nucleoside cotransporter 2
name: Sodium/nucleoside cotransporter 2 (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Sodium/purine nucleoside co- transporter) (SPNT)
name: Note: the coordinates are copied over from Homo sapiens.
name: Sodium-coupled nucleoside transporter 2
name: Sodium/nucleoside cotransporter 2
name: SLC28A2
name: Concentrative nucleoside transporter 2
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
name: hCNT2
xref: UnificationXref619
feature: FragmentFeature85
cellular location: plasma membrane
comment: Reactome DB_ID: 4232033
display name: CNT2

UnificationXref1905
type: UnificationXref
id: 77343
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77343

Creatinine
type: SmallMoleculeReference
name: Creatinine [ChEBI:16737]
name: 1-Methylglycocyamidine
xref: UnificationXref214

UnificationXref1904
type: UnificationXref
id: CHEBI:10723
db: ChEBI

UnificationXref1903
type: UnificationXref
id: REACT_83653
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83653.9

UnificationXref1902
type: UnificationXref
id: 4233362
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233362

phospho-p-S256-AQP2
type: Protein
entity reference: P60844
data source: Provenance1
xref: UnificationXref638
feature: ModificationFeature1
feature: FragmentFeature89
cellular location: plasma membrane
comment: Reactome DB_ID: 4232641

UnificationXref1901
type: UnificationXref
id: REACT_132148
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132148.5

http://identifiers.org/pubmed/19383790
type: PublicationXref
id: 19383790
author: Robbins, RA
author: Chorny, I
author: Miercke, LJ
author: Yeh, R
author: Ho, JD
author: Stroud, RM
author: Harries, WE
author: Sandstrom, A
db: Pubmed
title: Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance
source: Proc Natl Acad Sci U S A 106:7437-42
year: 2009

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P60844
data source: Provenance1
name: Aquaporin-1
name: AQP1_HUMAN
name: P60844
xref: UnificationXref635
feature: FragmentFeature88
cellular location: plasma membrane
comment: Reactome DB_ID: 4232624
display name: AQP1

UnificationXref1900
type: UnificationXref
id: 4231993
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P60844
data source: Provenance1
name: Lens fiber major intrinsic protein
name: P60844
name: MIP_HUMAN
xref: UnificationXref633
feature: FragmentFeature87
cellular location: plasma membrane
comment: Reactome DB_ID: 4232705
display name: MIP

CNT 2
type: Protein
entity reference: P33024
data source: Provenance1
name: P33024
name: SPNT
name: Sodium/purine nucleoside co- transporter
name: Na(+)/nucleoside cotransporter 2
name: Sodium/nucleoside cotransporter 2 (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Sodium/purine nucleoside co- transporter) (SPNT)
name: Note: the coordinates are copied over from Homo sapiens.
name: Sodium-coupled nucleoside transporter 2
name: Sodium/nucleoside cotransporter 2
name: SLC28A2
name: Concentrative nucleoside transporter 2
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
name: hCNT2
xref: UnificationXref620
feature: FragmentFeature86
cellular location: plasma membrane
comment: Reactome DB_ID: 4232034
display name: CNT2

D-Aspartic acid
type: SmallMolecule
entity reference: CHEBI:17364
data source: Provenance1
name: D-Aspartate
xref: UnificationXref28
xref: UnificationXref27
cellular location: GO:0005829
comment: Reactome DB_ID: 428044
display name: D-Asp

L-Glutaminic acid
type: SmallMolecule
entity reference: CHEBI:16015
data source: Provenance1
name: L-Glutamic acid
name: L-Glutamate
xref: UnificationXref26
xref: UnificationXref25
cellular location: GO:0005829
comment: Reactome DB_ID: 29404
display name: L-Glu

Sulfanilamide
type: SmallMoleculeReference
name: Sulfanilamide [ChEBI:9333]
xref: UnificationXref3767

sialic acid
type: SmallMolecule
entity reference: CHEBI:21622
data source: Provenance1
xref: UnificationXref95
xref: UnificationXref96
cellular location: GO:0005829
comment: Reactome DB_ID: 428633
display name: SA

sialic acid
type: SmallMolecule
entity reference: CHEBI:21622
data source: Provenance1
xref: UnificationXref93
xref: UnificationXref94
cellular location: lysosomal lumen
comment: Reactome DB_ID: 428639
display name: SA

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Provenance1
xref: UnificationXref91
xref: UnificationXref90
cellular location: lysosomal lumen
comment: Reactome DB_ID: 428040

L-Glutaminic acid
type: SmallMolecule
entity reference: CHEBI:16015
data source: Provenance1
name: L-Glutamic acid
name: L-Glutamate
xref: UnificationXref64
xref: UnificationXref65
cellular location: GO:0008021
comment: Reactome DB_ID: 428614
display name: Glu

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Provenance1
xref: UnificationXref62
xref: UnificationXref63
cellular location: GO:0008021
comment: Reactome DB_ID: 428548

Sodium
type: SmallMolecule
entity reference: CHEBI:29101
data source: Provenance1
name: sodium ion
xref: UnificationXref36
xref: UnificationXref35
cellular location: GO:0005829
comment: Reactome DB_ID: 83910
display name: Na+

proton
type: SmallMolecule
entity reference: CHEBI:15378
data source: Provenance1
xref: UnificationXref34
xref: UnificationXref33
cellular location: GO:0005829
comment: Reactome DB_ID: 70106
display name: H+

Potassium
type: SmallMolecule
entity reference: CHEBI:29103
data source: Provenance1
xref: UnificationXref32
xref: UnificationXref31
cellular location: extracellular region
comment: Reactome DB_ID: 74126
display name: K+

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P33021
data source: Provenance1
name: sodium-coupled nucleoside transporter, member 3
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
name: SLC28A3
xref: UnificationXref608
feature: FragmentFeature81
cellular location: plasma membrane
comment: Reactome DB_ID: 4232026
display name: P33021

Homologues of SLC28A3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref611
cellular location: plasma membrane
comment: Reactome DB_ID: 4232029
comment: Converted from EntitySet in Reactome

http://identifiers.org/pubmed/22074927
type: PublicationXref
id: 22074927
author: von Lintig, Johannes
db: Pubmed
title: Metabolism of carotenoids and retinoids related to vision
source: J. Biol. Chem. 287:1627-34
year: 2012

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P33024
data source: Provenance1
name: sodium-coupled nucleoside transporter, member 3
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
name: SLC28A3
xref: UnificationXref610
feature: FragmentFeature83
cellular location: plasma membrane
comment: Reactome DB_ID: 4232028
display name: P33024

http://identifiers.org/pubmed/22074928
type: PublicationXref
id: 22074928
author: Kefalov, Vladimir J
db: Pubmed
title: Rod and cone visual pigments and phototransduction through pharmacological, genetic, and physiological approaches
source: J. Biol. Chem. 287:1635-41
year: 2012

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AFF2
data source: Provenance1
name: sodium-coupled nucleoside transporter, member 3
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
name: SLC28A3
xref: UnificationXref609
feature: FragmentFeature82
cellular location: plasma membrane
comment: Reactome DB_ID: 4232027
display name: P0AFF2

CNT 2
type: Protein
entity reference: P33021
data source: Provenance1
name: SPNT
name: Sodium/purine nucleoside co- transporter
name: Na(+)/nucleoside cotransporter 2
name: Sodium/nucleoside cotransporter 2 (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Sodium/purine nucleoside co- transporter) (SPNT)
name: Note: the coordinates are copied over from Homo sapiens.
name: Sodium-coupled nucleoside transporter 2
name: P33021
name: Sodium/nucleoside cotransporter 2
name: SLC28A2
name: Concentrative nucleoside transporter 2
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
name: hCNT2
xref: UnificationXref618
feature: FragmentFeature84
cellular location: plasma membrane
comment: Reactome DB_ID: 4232032
display name: CNT2

UnificationXref1918
type: UnificationXref
id: 4231999
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231999

Homologues of SLC28A2
type: Protein
data source: Provenance1
member physical entity: CNT 2
xref: UnificationXref621
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232035

UnificationXref1917
type: UnificationXref
id: REACT_5128
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5128.1

http://identifiers.org/pubmed/17033958
type: PublicationXref
id: 17033958
author: Mrázová, L
author: Lepage, P
author: Verner, A
author: Hartmannová, H
author: Seyrantepe, V
author: Zeman, J
author: Urinovská, J
author: Hrebícek, M
author: Beesley, CE
author: Durand, S
author: Morgan, K
author: Pshezhetsky, AV
author: Poorthuis, BJ
author: Ivánek, R
author: Hudson, TJ
author: Poupetová, H
author: Roslin, NM
author: van de Kamp, J
author: Nosková, L
author: Wevers, RA
author: Majewski, J
author: Cízkova, A
author: Kmoch, S
author: Ausseil, J
author: van Diggelen, OP
author: Stranecký, V
author: Roquis, D
author: Fujiwara, TM
author: Sikora, J
author: Maire, I
db: Pubmed
title: Mutations in TMEM76* cause mucopolysaccharidosis IIIC (Sanfilippo C syndrome)
source: Am J Hum Genet 79:807-19
year: 2006

UnificationXref1919
type: UnificationXref
id: REACT_127276
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127276.5

4-methylthio-2-oxobutanoate (1-)
type: SmallMoleculeReference
name: ChEBI:16723 4-methylthio-2-oxobutanoate (1-)
xref: UnificationXref3549

UnificationXref1914
type: UnificationXref
id: REACT_5482
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5482.1

4-hydroxybutyrate
type: SmallMoleculeReference
name: 4-hydroxybutanoate
name: gamma-hydroxybutyrate
name: ChEBI:16724 4-hydroxybutyrate
xref: UnificationXref2625

UnificationXref1913
type: UnificationXref
id: 77339
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77339

UnificationXref1916
type: UnificationXref
id: 77337
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77337

UnificationXref1915
type: UnificationXref
id: CHEBI:15533
db: ChEBI

CNT 1
type: Protein
entity reference: P33021
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Sodium-coupled nucleoside transporter 1
name: Sodium/nucleoside cotransporter 1 (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1)
name: P33021
name: Na(+)/nucleoside cotransporter 1
name: Sodium/nucleoside cotransporter 1
name: Concentrative nucleoside transporter 1
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
name: SLC28A1
name: hCNT1
xref: UnificationXref586
feature: FragmentFeature78
cellular location: plasma membrane
comment: Reactome DB_ID: 4232016
display name: CNT1

UnificationXref1910
type: UnificationXref
id: 4232000
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232000

Homologues of SLC28A1
type: Protein
data source: Provenance1
member physical entity: CNT 1
xref: UnificationXref591
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232023

http://identifiers.org/pubmed/1837051
type: PublicationXref
id: 1837051
author: Grasso, M
author: Polak, JM
author: Arbustini, E
author: Wharton, J
author: Needleman, P
author: Viganò, M
author: Diegoli, M
author: Pucci, A
db: Pubmed
title: Atrial amyloid deposits in the failing human heart display both atrial and brain natriuretic peptide-like immunoreactivity
source: J Pathol 165:235-41
year: 1991

CNT 1
type: Protein
entity reference: P33024
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P33024
name: Sodium-coupled nucleoside transporter 1
name: Sodium/nucleoside cotransporter 1 (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1)
name: Na(+)/nucleoside cotransporter 1
name: Sodium/nucleoside cotransporter 1
name: Concentrative nucleoside transporter 1
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
name: SLC28A1
name: hCNT1
xref: UnificationXref590
feature: FragmentFeature80
cellular location: plasma membrane
comment: Reactome DB_ID: 4232022
display name: CNT1

UnificationXref1912
type: UnificationXref
id: CHEBI:28528
db: ChEBI

CNT 1
type: Protein
entity reference: UniProt:P0AFF2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Sodium-coupled nucleoside transporter 1
name: Sodium/nucleoside cotransporter 1 (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1)
name: P0AFF2
name: Na(+)/nucleoside cotransporter 1
name: Sodium/nucleoside cotransporter 1
name: Concentrative nucleoside transporter 1
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
name: SLC28A1
name: hCNT1
xref: UnificationXref588
feature: FragmentFeature79
cellular location: plasma membrane
comment: Reactome DB_ID: 4232019
display name: CNT1

UnificationXref1911
type: UnificationXref
id: REACT_92484
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92484.9

Cimetidine
type: SmallMolecule
entity reference: CHEBI:3699
data source: Provenance1
xref: UnificationXref213
xref: UnificationXref212
cellular location: GO:0005829
comment: Reactome DB_ID: 446602
display name: CIM

Guanidine
type: SmallMolecule
entity reference: CHEBI:42820
data source: Provenance1
xref: UnificationXref218
xref: UnificationXref219
cellular location: GO:0005829
comment: Reactome DB_ID: 446594
display name: Gu

Guanosine
type: SmallMoleculeReference
name: Guanosine [ChEBI:16750]
xref: UnificationXref594

Creatinine
type: SmallMolecule
entity reference: Creatinine
data source: Provenance1
name: 1-Methylglycocyamidine
xref: UnificationXref215
xref: UnificationXref216
cellular location: GO:0005829
comment: Reactome DB_ID: 30733
display name: CREAT

pyruvoyl group
type: SmallMoleculeReference
name: pyruvoyl group [ChEBI:45360]
name: CH3-CO-CO-
xref: UnificationXref2184

Procainamide
type: SmallMolecule
entity reference: Procainamide [ChEBI:8428]
data source: Provenance1
xref: UnificationXref224
xref: UnificationXref225
cellular location: GO:0005829
comment: Reactome DB_ID: 446598

Metformin
type: SmallMolecule
entity reference: Metformin [ChEBI:6801]
data source: Provenance1
xref: UnificationXref222
xref: UnificationXref221
cellular location: GO:0005829
comment: Reactome DB_ID: 446606
display name: MTF

MATE substrates
type: SmallMolecule
data source: Provenance1
member physical entity: Metformin
member physical entity: Cimetidine
member physical entity: Tetramethylammonium
member physical entity: Guanidine
member physical entity: Procainamide
member physical entity: Creatinine
member physical entity: 1-methyl-4-phenyl-pyridinium
xref: UnificationXref245
xref: UnificationXref246
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 446597

Tetramethylammonium
type: SmallMolecule
entity reference: CHEBI:46020
data source: Provenance1
xref: UnificationXref227
xref: UnificationXref228
cellular location: GO:0005829
comment: Reactome DB_ID: 446599
display name: TMAM

http://identifiers.org/pubmed/17707131
type: PublicationXref
id: 17707131
author: Waku, K
author: Suzuki, H
author: Kamata, R
author: Tanaka, K
author: Yamashita, A
author: Sugiura, T
author: Nakanishi, H
db: Pubmed
title: Topology of acyltransferase motifs and substrate specificity and accessibility in 1-acyl-sn-glycero-3-phosphate acyltransferase 1
source: Biochim Biophys Acta 1771:1202-15
year: 2007

Cimetidine
type: SmallMolecule
entity reference: CHEBI:3699
data source: Provenance1
xref: UnificationXref233
xref: UnificationXref234
cellular location: extracellular region
comment: Reactome DB_ID: 446609
display name: CIM

1-methyl-4-phenyl-pyridinium
type: SmallMolecule
entity reference: CHEBI:641
data source: Provenance1
xref: UnificationXref232
xref: UnificationXref231
cellular location: extracellular region
comment: Reactome DB_ID: 446607
display name: MPP

Creatinine
type: SmallMolecule
entity reference: Creatinine
data source: Provenance1
name: 1-Methylglycocyamidine
xref: UnificationXref235
xref: UnificationXref236
cellular location: extracellular region
comment: Reactome DB_ID: 446592
display name: CREAT

Uracil-6-carboxylic acid
type: SmallMoleculeReference
name: Orotic acid
name: Orotate
name: Orotate [ChEBI:16742]
xref: UnificationXref2907

http://identifiers.org/pubmed/8563765
type: PublicationXref
id: 8563765
author: Wright, EM
author: Lostao, MP
author: Kerner, C
author: Turk, E
author: Martin, MG
db: Pubmed
title: Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption
source: Nat Genet 12:216-20
year: 1996

UniProt:P0A7Z0
type: ProteinReference
xref: UnificationXref1726
organism: BioSource1

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine
data source: Provenance1
name: L-2-Aminoglutaramic acid
xref: UnificationXref156
xref: UnificationXref157
cellular location: extracellular region
comment: Reactome DB_ID: 212615
display name: L-Gln

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine
data source: Provenance1
name: L-2-Aminoglutaramic acid
xref: UnificationXref155
xref: UnificationXref154
cellular location: GO:0005829
comment: Reactome DB_ID: 29472
display name: L-Gln

http://identifiers.org/pubmed/15162420
type: PublicationXref
id: 15162420
author: Krawczyk, M
author: Reith, W
author: Fontana, A
author: Otten, LA
author: Waldburger, JM
author: Suter, T
author: Acha-Orbea, H
author: LeibundGut-Landmann, S
db: Pubmed
title: Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes
source: Eur J Immunol 34:1513-25
year: 2004

L-2-amino-3-mercaptopropionic acid
type: SmallMolecule
entity reference: CHEBI:17561
data source: Provenance1
name: L-cysteine
xref: UnificationXref138
xref: UnificationXref139
cellular location: extracellular region
comment: Reactome DB_ID: 352016
display name: Cys

L-Threonine
type: SmallMolecule
entity reference: L-Threonine
data source: Provenance1
xref: UnificationXref136
xref: UnificationXref137
cellular location: extracellular region
comment: Reactome DB_ID: 352000
display name: L-Thr

NADP+
type: SmallMolecule
entity reference: NADP+
data source: Provenance1
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref187
xref: UnificationXref186
cellular location: GO:0005829
comment: Reactome DB_ID: 29366
display name: TPN

Vitamin A1
type: SmallMolecule
entity reference: CHEBI:17336
data source: Provenance1
name: Retinol
name: Vitamin A
name: all-trans-Retinol
xref: UnificationXref183
xref: UnificationXref184
cellular location: GO:0005829
comment: Reactome DB_ID: 2473615
display name: atROL

NADPH
type: SmallMolecule
entity reference: CHEBI:16474
data source: Provenance1
xref: UnificationXref180
xref: UnificationXref181
cellular location: GO:0005829
comment: Reactome DB_ID: 29364
display name: TPNH

http://identifiers.org/pubmed/9427547
type: PublicationXref
id: 9427547
author: Taketani, S
author: Tokunaga, R
author: Kino, M
author: Kobayashi, Y
author: Ishihara, R
author: Sasai-Takedatsu, M
db: Pubmed
title: Molecular cloning, sequencing and expression of cDNA encoding human trehalase
source: Gene 202:69-74
year: 1997

all-trans-retinal
type: SmallMolecule
entity reference: all-trans-Retinene
data source: Provenance1
xref: UnificationXref178
xref: UnificationXref177
cellular location: GO:0005829
comment: Reactome DB_ID: 975622
display name: atRAL

http://identifiers.org/pubmed/9933641
type: PublicationXref
id: 9933641
author: Menon, AG
author: Szabó, EZ
author: Shull, GE
author: Baird, NR
author: Orlowski, J
author: Zaun, HC
author: Schultheis, PJ
db: Pubmed
title: Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain
source: J Biol Chem 274:4377-82
year: 1999

1-methyl-4-phenyl-pyridinium
type: SmallMolecule
entity reference: CHEBI:641
data source: Provenance1
xref: UnificationXref210
xref: UnificationXref209
cellular location: GO:0005829
comment: Reactome DB_ID: 446590
display name: MPP

MATE substrates
type: SmallMolecule
data source: Provenance1
member physical entity: 1-methyl-4-phenyl-pyridinium
member physical entity: Tetramethylammonium
member physical entity: Metformin
member physical entity: Procainamide
member physical entity: Creatinine
member physical entity: Cimetidine
member physical entity: Guanidine
xref: UnificationXref230
xref: UnificationXref229
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 446589

Phosphatidyl 1D-myo-inositol
type: SmallMoleculeReference
name: PI
name: ChEBI:16749 PI
xref: UnificationXref2230

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Provenance1
xref: UnificationXref401
xref: UnificationXref400
cellular location: GO:0005796
comment: Reactome DB_ID: 425969

Sodium
type: SmallMolecule
entity reference: CHEBI:29101
data source: Provenance1
name: sodium ion
xref: UnificationXref403
xref: UnificationXref402
cellular location: GO:0005796
comment: Reactome DB_ID: 425958
display name: Na+

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Provenance1
xref: UnificationXref410
xref: UnificationXref411
cellular location: GO:0031906
comment: Reactome DB_ID: 425999

UniProt:P0A867
type: ProteinReference
xref: UnificationXref1716
organism: BioSource1

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: ADP [ChEBI:16761]
data source: Provenance1
xref: UnificationXref362
xref: UnificationXref363
cellular location: GO:0005829
comment: Reactome DB_ID: 29370
display name: ADP

UnificationXref1941
type: UnificationXref
id: 77324
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77324

long-chain fatty acids
type: SmallMolecule
entity reference: CHEBI:15904
data source: Provenance1
xref: UnificationXref365
xref: UnificationXref366
cellular location: GO:0005782
comment: Reactome DB_ID: 382571
display name: LFCA

UnificationXref1940
type: UnificationXref
id: CHEBI:28706
db: ChEBI

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Provenance1
xref: UnificationXref392
xref: UnificationXref393
cellular location: GO:0031905
comment: Reactome DB_ID: 425978

Sodium ion
type: SmallMolecule
entity reference: CHEBI:29101
data source: Provenance1
xref: UnificationXref395
xref: UnificationXref394
cellular location: GO:0031905
comment: Reactome DB_ID: 425971
display name: Na+

Water
type: SmallMolecule
entity reference: CHEBI:15377
data source: Provenance1
xref: UnificationXref353
xref: UnificationXref354
cellular location: GO:0005829
comment: Reactome DB_ID: 29356
display name: H2O

long-chain fatty acids
type: SmallMolecule
entity reference: CHEBI:15904
data source: Provenance1
xref: UnificationXref357
xref: UnificationXref356
cellular location: GO:0005829
comment: Reactome DB_ID: 382577
display name: LCFA

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15422
data source: Provenance1
xref: UnificationXref359
xref: UnificationXref360
cellular location: GO:0005829
comment: Reactome DB_ID: 113592
display name: ATP

UnificationXref1948
type: UnificationXref
id: CHEBI:27648
db: ChEBI

UnificationXref1949
type: UnificationXref
id: 77320
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77320

UnificationXref1946
type: UnificationXref
id: 4231996
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231996

UnificationXref1947
type: UnificationXref
id: REACT_28770
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28770.10

UnificationXref1944
type: UnificationXref
id: 77322
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77322

UnificationXref1945
type: UnificationXref
id: REACT_3348
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3348.1

UnificationXref1942
type: UnificationXref
id: REACT_2759
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2759.1

http://identifiers.org/pubmed/1637327
type: PublicationXref
id: 1637327
author: Zimmermann, H
db: Pubmed
title: 5'-nucleotidase: molecular structure and functional aspects
source: Biochem J 285:345-365
year: 1992

UnificationXref1943
type: UnificationXref
id: CHEBI:28276
db: ChEBI

http://identifiers.org/pubmed/18650437
type: PublicationXref
id: 18650437
author: Marelja, Z
author: Nimtz, M
author: Stöcklein, W
author: Leimkühler, S
db: Pubmed
title: A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis
source: J Biol Chem 283:25178-85
year: 2008

Peptide chain elongation
type: Pathway
data source: Provenance1
pathway component: Peptide transfer from P-site tRNA to the A-site tRNA
pathway component: Translocation of ribosome by 3 bases in the 3' direction
evidence: Evidence142
xref: UnificationXref1048
xref: UnificationXref1047
pathway order: PathwayStep133
pathway order: PathwayStep134
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10510269
type: PublicationXref
id: 10510269
author: Amodeo, G
author: Ibarra, C
author: Berkowski, D
author: Zotta, E
author: Kierbel, A
author: Bigi, F
author: Silberstein, C
db: Pubmed
title: Functional characterization and localization of AQP3 in the human colon
source: Braz J Med Biol Res 32:1303-13
year: 1999

formamidopyrimidine
type: SmallMolecule
entity reference: formamidopyrimidine
data source: Provenance1
xref: UnificationXref334
xref: UnificationXref333
cellular location: nucleoplasm
comment: Reactome DB_ID: 110228
display name: FAPY

ethenocytosine
type: SmallMolecule
entity reference: CHEBI:29147
data source: Provenance1
xref: UnificationXref338
xref: UnificationXref339
cellular location: nucleoplasm
comment: Reactome DB_ID: 110233
display name: EtCYS

Thymine
type: SmallMolecule
entity reference: Thymine
data source: Provenance1
xref: UnificationXref316
xref: UnificationXref317
cellular location: nucleoplasm
comment: Reactome DB_ID: 29692
display name: Thy

2,4(1H,3H)-Pyrimidinedione, dihydro-
type: SmallMolecule
entity reference: CHEBI:15901
data source: Provenance1
name: Dihydrouracile
name: 5,6-Dihydrouracil
name: 5,6-Dihydro-2,4-dihydroxypyrimidine
name: dihydrouracil
xref: UnificationXref328
xref: UnificationXref329
cellular location: nucleoplasm
comment: Reactome DB_ID: 30140
display name: Hydrouracil

8-oxoguanine
type: SmallMolecule
entity reference: CHEBI:44605
data source: Provenance1
xref: UnificationXref266
xref: UnificationXref265
cellular location: nucleoplasm
comment: Reactome DB_ID: 110242
display name: OGUA

UnificationXref1950
type: UnificationXref
id: REACT_4535
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4535.1

Uracil
type: SmallMolecule
entity reference: CHEBI:17568
data source: Provenance1
xref: UnificationXref310
xref: UnificationXref311
cellular location: nucleoplasm
comment: Reactome DB_ID: 29554
display name: Ura

Procainamide
type: SmallMolecule
entity reference: Procainamide [ChEBI:8428]
data source: Provenance1
xref: UnificationXref241
xref: UnificationXref242
cellular location: extracellular region
comment: Reactome DB_ID: 446596

UnificationXref1952
type: UnificationXref
id: 77318
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77318

Tetramethylammonium
type: SmallMolecule
entity reference: CHEBI:46020
data source: Provenance1
xref: UnificationXref243
xref: UnificationXref244
cellular location: extracellular region
comment: Reactome DB_ID: 446604
display name: TMAM

UnificationXref1951
type: UnificationXref
id: CHEBI:15517
db: ChEBI

Guanidine
type: SmallMolecule
entity reference: CHEBI:42820
data source: Provenance1
xref: UnificationXref238
xref: UnificationXref237
cellular location: extracellular region
comment: Reactome DB_ID: 446595
display name: Gu

Metformin
type: SmallMolecule
entity reference: Metformin [ChEBI:6801]
data source: Provenance1
xref: UnificationXref239
xref: UnificationXref240
cellular location: extracellular region
comment: Reactome DB_ID: 446603
display name: MTF

http://identifiers.org/pubmed/10889450
type: PublicationXref
id: 10889450
author: Lemaire, G
author: Löffler, M
author: Auger, R
author: Guissani, A
author: Lepoivre, M
author: Beuneu, C
db: Pubmed
title: Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide.
source: Free Radic Biol Med 28:1206-13
year: 2000

UnificationXref1957
type: UnificationXref
id: REACT_85567
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85567.9

UnificationXref1958
type: UnificationXref
id: CHEBI:15473
db: ChEBI

UnificationXref1959
type: UnificationXref
id: 77313
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77313

UnificationXref1953
type: UnificationXref
id: REACT_4131
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4131.2

UnificationXref1954
type: UnificationXref
id: 4231995
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231995

UnificationXref1955
type: UnificationXref
id: REACT_134407
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134407.5

UnificationXref1956
type: UnificationXref
id: 4233367
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233367

UniProt:P0A858
type: ProteinReference
xref: UnificationXref1486
organism: BioSource1

zinc
type: SmallMolecule
entity reference: CHEBI:29105
data source: Provenance1
name: Zn(II)
name: Zn++
xref: UnificationXref537
xref: UnificationXref538
cellular location: GO:0008021
comment: Reactome DB_ID: 437093
display name: Zn2+

UniProt:P0A887
type: ProteinReference
xref: UnificationXref2506
organism: BioSource1

http://identifiers.org/pubmed/11278511
type: PublicationXref
id: 11278511
author: Ding, WC
author: Berger, SH
author: Lebioda, L
author: Koli, S
author: Minor, W
author: Dunlap, RB
author: Phan, J
author: Steadman, DJ
db: Pubmed
title: Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
source: J Biol Chem 276:14170-7
year: 2001

http://identifiers.org/pubmed/7493035
type: PublicationXref
id: 7493035
author: Morris, CP
author: Hopwood, JJ
author: Blanch, L
author: Guo, XH
author: Sutherland, GR
author: Freeman, C
author: Baker, E
author: Orsborn, A
author: Scott, HS
db: Pubmed
title: Cloning of the sulphamidase gene and identification of mutations in Sanfilippo A syndrome
source: Nat Genet 11:465-7
year: 1995

UniProt:P0A884
type: ProteinReference
xref: UnificationXref1233
organism: BioSource1

Inositol
type: SmallMolecule
entity reference: CHEBI:17268
data source: Provenance1
name: Myo-inositol
xref: UnificationXref501
xref: UnificationXref500
cellular location: extracellular region
comment: Reactome DB_ID: 429130
display name: Ins

Inositol
type: SmallMolecule
entity reference: CHEBI:17268
data source: Provenance1
name: Myo-inositol
xref: UnificationXref503
xref: UnificationXref502
cellular location: GO:0005829
comment: Reactome DB_ID: 426910
display name: Ins

Inositols transported by SMIT2
type: SmallMolecule
data source: Provenance1
member physical entity: Inositol
member physical entity: D-chiro-inositol
xref: UnificationXref511
xref: UnificationXref510
cellular location: extracellular region
comment: Reactome DB_ID: 429652
comment: Converted from EntitySet in Reactome

D-chiro-inositol
type: SmallMolecule
entity reference: 1D-chiro-inositol
data source: Provenance1
xref: UnificationXref509
xref: UnificationXref508
cellular location: extracellular region
comment: Reactome DB_ID: 429585
display name: CHI

Inositols transported by SMIT2
type: SmallMolecule
data source: Provenance1
member physical entity: D-chiro-inositol
member physical entity: Inositol
xref: UnificationXref515
xref: UnificationXref514
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 429648

D-chiro-inositol
type: SmallMolecule
entity reference: 1D-chiro-inositol
data source: Provenance1
xref: UnificationXref513
xref: UnificationXref512
cellular location: GO:0005829
comment: Reactome DB_ID: 429640
display name: CHI

Zn(II)
type: SmallMolecule
entity reference: CHEBI:29105
data source: Provenance1
name: Zn++
name: Zinc ion
xref: UnificationXref528
xref: UnificationXref529
cellular location: GO:0005829
comment: Reactome DB_ID: 29426
display name: Zn2+

Zn(II)
type: SmallMolecule
entity reference: CHEBI:29105
data source: Provenance1
name: Zn++
name: Zinc ion
xref: UnificationXref532
xref: UnificationXref531
cellular location: GO:0031904
comment: Reactome DB_ID: 435350
display name: Zn2+

http://identifiers.org/pubmed/10694408
type: PublicationXref
id: 10694408
author: Patel, S
author: Kraemer, FB
author: Hong, R
author: Shen, WJ
db: Pubmed
title: Hormone-sensitive lipase functions as an oligomer
source: Biochemistry 39:2392-8
year: 2000

UnificationXref1922
type: UnificationXref
id: CHEBI:27537
db: ChEBI

UnificationXref1923
type: UnificationXref
id: 77332
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77332

UnificationXref1920
type: UnificationXref
id: 4233369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233369

http://identifiers.org/pubmed/19943854
type: PublicationXref
id: 19943854
author: Campos-Pena, Victoria
author: Mena-Lopez, Raul
author: De Anda-Hernandez, Martha A
author: Meraz-Rios, Marco A
author: Lira-De Leon, Karla I
db: Pubmed
title: Tau oligomers and aggregation in Alzheimer's disease
source: J Neurochem 112:1353-67
year: 2010

UnificationXref1921
type: UnificationXref
id: REACT_81455
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81455.9

UnificationXref1926
type: UnificationXref
id: 77330
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77330

UnificationXref1927
type: UnificationXref
id: REACT_2973
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2973.1

D-mannose
type: SmallMolecule
entity reference: Carubinose
data source: Provenance1
xref: UnificationXref491
xref: UnificationXref490
cellular location: GO:0005829
comment: Reactome DB_ID: 429579
display name: Man

UnificationXref1924
type: UnificationXref
id: REACT_5037
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5037.1

UnificationXref1925
type: UnificationXref
id: CHEBI:28632
db: ChEBI

UnificationXref1928
type: UnificationXref
id: 4231998
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231998

UnificationXref1929
type: UnificationXref
id: REACT_100244
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100244.9

D-mannose
type: SmallMolecule
entity reference: Carubinose
data source: Provenance1
xref: UnificationXref487
xref: UnificationXref486
cellular location: extracellular region
comment: Reactome DB_ID: 429635
display name: Man

hexoses transported by SGLT4
type: SmallMolecule
data source: Provenance1
member physical entity: alpha-D-glucose
member physical entity: D-mannose
xref: UnificationXref493
xref: UnificationXref492
cellular location: GO:0005829
comment: Reactome DB_ID: 429628
comment: Converted from EntitySet in Reactome

http://identifiers.org/pubmed/6372096
type: PublicationXref
id: 6372096
author: Horwich, AL
author: Doolittle, RF
author: Rosenberg, LE
author: Fenton, WA
author: Konigsberg, W
author: Kalousek, F
author: Williams, KR
author: Kraus, JP
db: Pubmed
title: Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase.
source: Science 224:1068-74
year: 1984

D-galactose
type: SmallMolecule
entity reference: CHEBI:17118
data source: Provenance1
xref: UnificationXref446
xref: UnificationXref447
cellular location: extracellular region
comment: Reactome DB_ID: 188995
display name: Gal

UniProt:P0A870
type: ProteinReference
xref: UnificationXref1714
organism: BioSource1

alpha-D-glucose
type: SmallMolecule
entity reference: alpha-D-Glucose [ChEBI:17925]
data source: Provenance1
xref: UnificationXref450
xref: UnificationXref449
cellular location: extracellular region
comment: Reactome DB_ID: 70115
display name: Glc

Sodium ion
type: SmallMolecule
entity reference: CHEBI:29101
data source: Provenance1
xref: UnificationXref413
xref: UnificationXref412
cellular location: GO:0031906
comment: Reactome DB_ID: 425977
display name: Na+

hexoses transported by SGLT1
type: SmallMolecule
data source: Provenance1
member physical entity: alpha-D-glucose
member physical entity: D-galactose
name: galactose, glucose
xref: UnificationXref452
xref: UnificationXref451
cellular location: extracellular region
comment: Reactome DB_ID: 189227
comment: Converted from EntitySet in Reactome
display name: Gal, Glc

http://identifiers.org/pubmed/8617223
type: PublicationXref
id: 8617223
author: Cole, TB
author: Findley, SD
author: Palmiter, RD
db: Pubmed
title: ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration
source: EMBO J 15:1784-91
year: 1996

alpha-D-glucose
type: SmallMolecule
entity reference: alpha-D-Glucose [ChEBI:17925]
data source: Provenance1
xref: UnificationXref456
xref: UnificationXref455
cellular location: GO:0005829
comment: Reactome DB_ID: 70113
display name: Glc

hexoses transported by SGLT4
type: SmallMolecule
data source: Provenance1
member physical entity: D-mannose
member physical entity: alpha-D-glucose
xref: UnificationXref489
xref: UnificationXref488
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 429620

hexoses transported by SGLT1
type: SmallMolecule
data source: Provenance1
member physical entity: alpha-D-glucose
member physical entity: D-galactose
name: galactose, glucose
xref: UnificationXref458
xref: UnificationXref457
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 189254
display name: Gal, Glc

UnificationXref1930
type: UnificationXref
id: CHEBI:28264
db: ChEBI

UniProt:P0AGK1
type: ProteinReference
xref: UnificationXref2461
organism: BioSource1

D-galactose
type: SmallMolecule
entity reference: CHEBI:17118
data source: Provenance1
xref: UnificationXref454
xref: UnificationXref453
cellular location: GO:0005829
comment: Reactome DB_ID: 29590
display name: Gal

UnificationXref1931
type: UnificationXref
id: 77328
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77328

http://identifiers.org/pubmed/18538142
type: PublicationXref
id: 18538142
author: Hunt, MC
author: Alexson, SE
db: Pubmed
title: Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism
source: Prog Lipid Res 47:405-21
year: 2008

UnificationXref1932
type: UnificationXref
id: REACT_4358
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4358.1

6-aminopurine
type: SmallMoleculeReference
name: adenine [ChEBI:16708]
name: adenine
xref: UnificationXref2814

UnificationXref1933
type: UnificationXref
id: CHEBI:27540
db: ChEBI

UnificationXref1934
type: UnificationXref
id: 77326
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77326

UnificationXref1935
type: UnificationXref
id: REACT_5004
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5004.2

UnificationXref1936
type: UnificationXref
id: 4231997
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231997

Uridine [ChEBI:16704]
type: SmallMoleculeReference
name: Uridine
xref: UnificationXref568

UnificationXref1937
type: UnificationXref
id: REACT_125728
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125728.5

UnificationXref1938
type: UnificationXref
id: 4233368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233368

UnificationXref1939
type: UnificationXref
id: REACT_28573
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28573.10

http://identifiers.org/pubmed/21781017
type: PublicationXref
id: 21781017
author: Pulimeno, P
author: Stutz, J
author: Spadaro, D
author: Schneider, Y
author: Citi, S
db: Pubmed
title: Regulation of small GTPases at epithelial cell-cell junctions
source: Mol Membr Biol
year: 2011

Pyridoxol
type: SmallMoleculeReference
name: Pyridoxine
name: Pyridoxine [ChEBI:8671]
xref: UnificationXref3192

Phenylalanine and tyrosine catabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction307
pathway component: BiochemicalReaction308
evidence: Evidence525
xref: UnificationXref3461
xref: RelationshipXref508
xref: UnificationXref3460
pathway order: PathwayStep512
pathway order: PathwayStep511
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction148
pathway component: BiochemicalReaction146
pathway component: BiochemicalReaction147
evidence: Evidence283
xref: UnificationXref1794
xref: RelationshipXref228
xref: UnificationXref1795
pathway order: PathwayStep269
pathway order: PathwayStep268
pathway order: PathwayStep267
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/13115431
type: PublicationXref
id: 13115431
author: Lieberman, I
author: Kornberg, A
db: Pubmed
title: Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase
source: Biochim Biophys Acta 12:223-234
year: 1953

UniProt:P06715
type: ProteinReference
xref: UnificationXref3121
organism: BioSource1

UniProt:P0AGG4
type: ProteinReference
xref: UnificationXref775
organism: BioSource1

UniProt:P0AGG2
type: ProteinReference
xref: UnificationXref2086
organism: BioSource1

N-Hydroxy-4-aminobiphenyl
type: SmallMoleculeReference
name: N-Hydroxy-4-aminobiphenyl [ChEBI:16580]
xref: UnificationXref3758

http://identifiers.org/pubmed/13295248
type: PublicationXref
id: 13295248
author: Stern, JR
author: Del Campillo, A
db: Pubmed
title: Enzymes of fatty acid metabolism. II. Properties of crystalline crotonase.
source: J Biol Chem 218:985-1002
year: 1956

delta3-methyl-3-butenyl diphosphate
type: SmallMoleculeReference
name: delta3-Isopentenyl diphosphate
name: Isopentenyl diphosphate [ChEBI:6037]
name: Isopentenyl diphosphate
xref: UnificationXref2133

http://identifiers.org/pubmed/20188572
type: PublicationXref
id: 20188572
author: von Lintig, Johannes
author: Palczewski, Krzysztof
author: Kiser, Philip D
author: Golczak, Marcin
db: Pubmed
title: The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision
source: Trends Biochem. Sci. 35:400-10
year: 2010

tRNA Aminoacylation
type: Pathway
data source: Provenance1
pathway component: REACT 82393.9
pathway component: REACT 100041.9
evidence: Evidence141
xref: RelationshipXref93
xref: UnificationXref978
xref: UnificationXref977
pathway order: PathwayStep131
pathway order: PathwayStep119
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/153835
type: PublicationXref
id: 153835
author: Kresse, H
author: von Figura, K
author: Klein, U
db: Pubmed
title: A new biochemical subtype of the Sanfilippo syndrome: characterization of the storage material in cultured fibroblasts of Sanfilippo C patients
source: Eur J Biochem 92:333-9
year: 1978

http://identifiers.org/pubmed/22952392
type: PublicationXref
id: 22952392
author: Nusse, Roel
author: Willert, Karl
db: Pubmed
title: Wnt proteins
source: Cold Spring Harb Perspect Biol 4:a007864
year: 2012

http://identifiers.org/pubmed/5324173
type: PublicationXref
id: 5324173
author: Berg, P
author: Baldwin, AN
db: Pubmed
title: Transfer ribonucleic acid-induced hydrolysis of valyladenylate bound to isoleucyl ribonucleic acid synthetase
source: J Biol Chem 241:839-45
year: 1966

http://identifiers.org/pubmed/5324172
type: PublicationXref
id: 5324172
author: Berg, P
author: Baldwin, AN
db: Pubmed
title: Purification and properties of isoleucyl ribonucleic acid synthetase from Escherichia coli
source: J Biol Chem 241:831-8
year: 1966

UniProt:P04693
type: ProteinReference
xref: UnificationXref1583
organism: BioSource1

http://identifiers.org/pubmed/1592113
type: PublicationXref
id: 1592113
author: Powell, SM
author: Dixon, JE
author: Zalkin, H
db: Pubmed
title: Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase
source: FEBS Lett 303:4-20
year: 1992

http://identifiers.org/pubmed/15784477
type: PublicationXref
id: 15784477
author: Cynober, L
author: Moinard, C
author: de Bandt, JP
db: Pubmed
title: Polyamines: metabolism and implications in human diseases
source: Clin Nutr 24:184-97
year: 2005

UniProt:P0AGJ9
type: ProteinReference
xref: UnificationXref970
organism: BioSource1

UniProt:P62601
type: ProteinReference
xref: UnificationXref1440
organism: BioSource1

UnificationXref3317
type: UnificationXref
id: REACT_26179
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26179.2

UnificationXref3318
type: UnificationXref
id: CHEBI:59648
db: ChEBI

UnificationXref3319
type: UnificationXref
id: 947537
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=947537

http://identifiers.org/pubmed/18400693
type: PublicationXref
id: 18400693
author: Dorwart, MR
author: Muallem, S
author: Yang, D
author: Shcheynikov, N
db: Pubmed
title: The solute carrier 26 family of proteins in epithelial ion transport
source: Physiology (Bethesda) 23:104-14
year: 2008

http://identifiers.org/pubmed/19737925
type: PublicationXref
id: 19737925
author: Taylor, WA
author: Hatch, GM
db: Pubmed
title: Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1)
source: J Biol Chem 284:30360-71
year: 2009

UnificationXref3314
type: UnificationXref
id: REACT_5892
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5892.2

UnificationXref3313
type: UnificationXref
id: 71284
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71284

UnificationXref3316
type: UnificationXref
id: 947703
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=947703

UniProt:P76503
type: ProteinReference
xref: UnificationXref1844
organism: BioSource1

UnificationXref3315
type: UnificationXref
id: CHEBI:17319
db: ChEBI

UnificationXref3310
type: UnificationXref
id: REACT_152985
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152985.3

UnificationXref3312
type: UnificationXref
id: REACT_31379
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31379.10

UnificationXref3311
type: UnificationXref
id: 4233428
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233428

UnificationXref3308
type: UnificationXref
id: REACT_155706
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155706.3

UnificationXref3309
type: UnificationXref
id: 4232306
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232306

UnificationXref3306
type: UnificationXref
id: REACT_33585
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33585.10

http://identifiers.org/pubmed/2462567
type: PublicationXref
id: 2462567
author: de Jong, WW
author: Stapel, SO
author: Lietman, T
author: Wistow, GJ
author: Piatigorsky, J
author: Williams, LA
author: Horwitz, J
db: Pubmed
title: Tau-crystallin/alpha-enolase: one gene encodes both an enzyme and a lens structural protein
source: J Cell Biol 107:2729-36
year: 1988

UnificationXref3307
type: UnificationXref
id: 4232292
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232292

UniProt:P0A9C0
type: ProteinReference
xref: UnificationXref2048
organism: BioSource1

alpha,alpha-Trehalose
type: SmallMoleculeReference
name: alpha,alpha-Trehalose [ChEBI:10202]
name: Trehalose
name: alpha,alpha'-Trehalose
xref: UnificationXref1434

http://identifiers.org/pubmed/12668600
type: PublicationXref
id: 12668600
author: Herman, GE
db: Pubmed
title: Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes
source: Hum Mol Genet 12:R75-88
year: 2003

http://identifiers.org/pubmed/21220505
type: PublicationXref
id: 21220505
author: Langer, T
author: Voelker, DR
author: Osman, C
db: Pubmed
title: Making heads or tails of phospholipids in mitochondria
source: J Cell Biol 192:7-16
year: 2011

UnificationXref3305
type: UnificationXref
id: 4232300
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232300

UnificationXref3304
type: UnificationXref
id: 4232298
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232298

UniProt:P0AGD1
type: ProteinReference
xref: UnificationXref794
organism: BioSource1

UnificationXref3303
type: UnificationXref
id: 4232297
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232297

UnificationXref3302
type: UnificationXref
id: P0AEZ1
db: UniProt

UnificationXref3301
type: UnificationXref
id: REACT_153629
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153629.3

UnificationXref3300
type: UnificationXref
id: 4232305
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232305

UnificationXref3339
type: UnificationXref
id: MOD:00274
db: MOD

http://identifiers.org/pubmed/12324224
type: PublicationXref
id: 12324224
author: Sprecher, H
db: Pubmed
title: The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids
source: Prostaglandins Leukot Essent Fatty Acids 67:79-83
year: 2002

UniProt:P0AGE9
type: ProteinReference
xref: UnificationXref2588
organism: BioSource1

CO2 [ChEBI:16526]
type: SmallMoleculeReference
name: CO2
name: Carbon dioxide
xref: UnificationXref1547

http://identifiers.org/pubmed/11231887
type: PublicationXref
id: 11231887
author: Fischer, H
author: Lindblom, A
author: Rubio, C
author: Stenling, R
db: Pubmed
title: Differential expression of aquaporin 8 in human colonic epithelial cells and colorectal tumors
source: BMC Physiol 1:1
year: 2001

UnificationXref3330
type: UnificationXref
id: 4232884
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232884

UnificationXref3332
type: UnificationXref
id: REACT_133359
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133359.5

http://identifiers.org/pubmed/11371164
type: PublicationXref
id: 11371164
author: Li, X
author: Davies, C
author: Pearce, J
author: Muirhead, H
author: Chirgwin, J
author: Read, J
db: Pubmed
title: The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia
source: J Mol Biol 309:447-63
year: 2001

UnificationXref3331
type: UnificationXref
id: 4232886
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232886

UniProt:P0AGE4
type: ProteinReference
xref: UnificationXref41
organism: BioSource1

UnificationXref3334
type: UnificationXref
id: 4232855
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232855

UnificationXref3333
type: UnificationXref
id: P30138
db: UniProt

UnificationXref3336
type: UnificationXref
id: 4232858
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232858

UnificationXref3335
type: UnificationXref
id: P12282
db: UniProt

UnificationXref3338
type: UnificationXref
id: 4232860
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232860

UnificationXref3337
type: UnificationXref
id: 4232859
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232859

UnificationXref3328
type: UnificationXref
id: REACT_26717
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26717.2

UnificationXref3329
type: UnificationXref
id: 4232882
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232882

http://identifiers.org/pubmed/9188776
type: PublicationXref
id: 9188776
author: Rider, MH
author: Veiga-da-Cunha, M
author: Gerin, I
author: Van Schaftingen, E
author: Collet, JF
db: Pubmed
title: Human L-3-phosphoserine phosphatase: sequence, expression and evidence for a phosphoenzyme intermediate
source: FEBS Lett 408:281-4
year: 1997

5,10-methylenetetrahydrofolate polyglutamate
type: SmallMoleculeReference
name: 5,10-methylenetetrahydrofolate polyglutamate macromolecule
name: 5,10-methylenetetrahydrofolate polyglutamate macromolecule [ChEBI:60473]
xref: UnificationXref3297

UnificationXref3323
type: UnificationXref
id: REACT_7480
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7480.3

UnificationXref3322
type: UnificationXref
id: 174390
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174390

http://identifiers.org/pubmed/16968948
type: PublicationXref
id: 16968948
author: Brink, C
author: Serhan, CN
author: Shimizu, T
author: Rovati, GE
author: Hay, DW
author: Yokomizo, T
author: Chiang, N
author: Drazen, JM
author: Dahlén, SE
db: Pubmed
title: The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo
source: Pharmacol Rev 58:463-87
year: 2006

UnificationXref3321
type: UnificationXref
id: CHEBI:16643
db: ChEBI

UnificationXref3320
type: UnificationXref
id: REACT_26434
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26434.1

UnificationXref3327
type: UnificationXref
id: 937126
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=937126

UnificationXref3326
type: UnificationXref
id: CHEBI:33722
db: ChEBI

UnificationXref3325
type: UnificationXref
id: 4232883
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232883

UniProt:P0AGF4
type: ProteinReference
xref: UnificationXref470
organism: BioSource1

UnificationXref3324
type: UnificationXref
id: P30745
db: UniProt

UnificationXref3359
type: UnificationXref
id: 947496
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=947496

3-decaprenyl-4-hydroxy-5-methoxybenzoic acid
type: SmallMoleculeReference
name: 4-hydroxy-3-methoxy-5-decaprenylbenzoic acid
name: all-trans-4-hydroxy-3-methoxy-5-decaprenylbenzoic acid
name: 3-decaprenyl-4-hydroxy-5-methoxybenzoic acid [ChEBI:50776]
name: all-trans-3-decaprenyl-4-hydroxy-5-methoxybenzoic acid
xref: UnificationXref2493

4-Trimethylammoniobutanal
type: SmallMoleculeReference
name: 4-Trimethylammoniobutanal [ChEBI:18020]
xref: UnificationXref3519

Hexanoyl-CoA
type: SmallMoleculeReference
name: Hexanoyl-CoA [ChEBI:27540]
xref: UnificationXref1933

UnificationXref3357
type: UnificationXref
id: 4232896
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232896

MPS IX - Natowicz syndrome
type: Pathway
data source: Provenance1
pathway component: Glycosaminoglycan metabolism
evidence: Evidence225
xref: UnificationXref1427
xref: UnificationXref1426
pathway order: PathwayStep202
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Phosphoenolpyruvic acid
type: SmallMoleculeReference
name: Phosphoenolpyruvate
name: Phosphoenolpyruvate [ChEBI:18021]
name: PEP
xref: UnificationXref1516

UnificationXref3358
type: UnificationXref
id: CHEBI:58698
db: ChEBI

Precursor Z
type: SmallMolecule
entity reference: CHEBI:59648
data source: Provenance1
xref: UnificationXref3320
xref: UnificationXref3319
cellular location: GO:0005829
comment: Reactome DB_ID: 947537

Facilitative Na+-independent glucose transporters
type: Pathway
data source: Provenance1
pathway component: Glucose transport by class III GLUTs
evidence: Evidence70
xref: UnificationXref481
xref: UnificationXref480
pathway order: PathwayStep63
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3355
type: UnificationXref
id: REACT_131611
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131611.5

UnificationXref3356
type: UnificationXref
id: 4232895
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232895

UnificationXref3353
type: UnificationXref
id: 4232891
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232891

UnificationXref3354
type: UnificationXref
id: 4232894
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232894

Phase II conjugation
type: Pathway
data source: Provenance1
pathway component: REACT 113503.8
pathway component: REACT 84346.9
pathway component: Cytosolic sulfonation of small molecules
pathway component: REACT 144525.5
evidence: Evidence579
xref: UnificationXref3856
xref: UnificationXref3857
xref: RelationshipXref568
pathway order: PathwayStep562
pathway order: PathwayStep558
pathway order: PathwayStep557
pathway order: PathwayStep565
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3351
type: UnificationXref
id: 4232892
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232892

UnificationXref3352
type: UnificationXref
id: MOD:01625
db: MOD

UnificationXref3350
type: UnificationXref
id: 4232889
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232889

3-decaprenyl-4,5-dihydroxybenzoic acid [ChEBI:50775]
type: SmallMoleculeReference
name: 3-decaprenyl-4,5-dihydroxybenzoic acid
name: 3-(3,7,11,15,19,23,27,31,35,39-decamethyltetracosa-2,6,10,14,18,22,26,30,34,38-decaenyl)-4,5-dihydroxybenzoic acid
name: all-trans-3-decaprenyl-4,5-dihydroxybenzoic acid
name: all-trans-3,4-dihydroxy-5-decaprenylbenzoic acid
name: 3,4-dihydroxy-5-decaprenylbenzoic acid
xref: UnificationXref2470

L-Methionine
type: SmallMolecule
entity reference: L-2-Amino-4methylthiobutyric acid
data source: Provenance1
xref: UnificationXref3322
xref: UnificationXref3323
cellular location: GO:0005829
comment: Reactome DB_ID: 174390
display name: L-Met

(4Fe-4S)(2+)
type: SmallMolecule
entity reference: [4Fe-4S](2+)
data source: Provenance1
xref: UnificationXref3328
xref: UnificationXref3327
cellular location: GO:0005829
comment: Reactome DB_ID: 937126

MoCo
type: SmallMolecule
entity reference: CHEBI:25372
data source: Provenance1
xref: UnificationXref3368
xref: UnificationXref3369
cellular location: GO:0005829
comment: Reactome DB_ID: 947539

L-Glutamate gamma-semialdehyde
type: SmallMolecule
entity reference: CHEBI:17232
data source: Provenance1
name: L-Glutamate 5-semialdehyde
xref: UnificationXref3388
xref: UnificationXref3387
cellular location: GO:0005759
comment: Reactome DB_ID: 31339
display name: L-Glu5S

Molybdopterin
type: SmallMolecule
entity reference: CHEBI:58698
data source: Provenance1
xref: UnificationXref3360
xref: UnificationXref3359
cellular location: GO:0005829
comment: Reactome DB_ID: 947496
display name: MPT

molybdate(2-)
type: SmallMolecule
entity reference: CHEBI:36264
data source: Provenance1
xref: UnificationXref3365
xref: UnificationXref3366
cellular location: GO:0005829
comment: Reactome DB_ID: 947561
display name: MoO4(2-)

O-phospho-L-serine
type: SmallMolecule
entity reference: L-O-Phosphoserine
data source: Provenance1
xref: UnificationXref3411
xref: UnificationXref3412
cellular location: GO:0005829
comment: Reactome DB_ID: 936706

L-alpha-Aminoadipic acid
type: SmallMolecule
entity reference: CHEBI:17082
data source: Provenance1
name: L-2-Aminoadipate
name: L-2-Aminoadipic acid
name: L-alpha-Aminoadipate
xref: UnificationXref3428
xref: UnificationXref3429
cellular location: GO:0005759
comment: Reactome DB_ID: 508531
display name: 2AMA

L-Asparagine
type: SmallMolecule
entity reference: CHEBI:17196
data source: Provenance1
name: 2-Aminosuccinamic acid
xref: UnificationXref3397
xref: UnificationXref3398
cellular location: GO:0005829
comment: Reactome DB_ID: 29642
display name: L-Asn

3-phosphonooxypyruvic acid
type: SmallMolecule
entity reference: CHEBI:30933
data source: Provenance1
xref: UnificationXref3403
xref: UnificationXref3404
cellular location: GO:0005829
comment: Reactome DB_ID: 977329

UnificationXref3346
type: UnificationXref
id: 4232870
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232870

UnificationXref3347
type: UnificationXref
id: 4232872
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232872

UnificationXref3348
type: UnificationXref
id: REACT_147410
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147410.5

http://identifiers.org/pubmed/18625006
type: PublicationXref
id: 18625006
author: Norbeck, J
author: Pirkov, I
author: Albers, E
author: Gustafsson, L
db: Pubmed
title: A complete inventory of all enzymes in the eukaryotic methionine salvage pathway
source: FEBS J 275:4111-20
year: 2008

UnificationXref3349
type: UnificationXref
id: P30749
db: UniProt

UnificationXref3342
type: UnificationXref
id: 4232865
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232865

UnificationXref3343
type: UnificationXref
id: 4232866
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232866

UnificationXref3344
type: UnificationXref
id: P0A6B7
db: UniProt

UnificationXref3345
type: UnificationXref
id: 4232869
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232869

Synthesis and interconversion of nucleotide di- and triphosphates
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction264
pathway component: BiochemicalReaction261
pathway component: BiochemicalReaction263
pathway component: BiochemicalReaction265
pathway component: BiochemicalReaction258
pathway component: BiochemicalReaction259
pathway component: BiochemicalReaction262
pathway component: BiochemicalReaction266
pathway component: BiochemicalReaction260
evidence: Evidence468
xref: UnificationXref3130
xref: RelationshipXref438
xref: UnificationXref3131
pathway order: PathwayStep454
pathway order: PathwayStep452
pathway order: PathwayStep449
pathway order: PathwayStep451
pathway order: PathwayStep447
pathway order: PathwayStep450
pathway order: PathwayStep453
pathway order: PathwayStep448
pathway order: PathwayStep446
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3340
type: UnificationXref
id: 4232862
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232862

UnificationXref3341
type: UnificationXref
id: 4232864
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232864

Activation of Chaperones by ATF6-alpha
type: Pathway
data source: Provenance1
pathway component: Activation of Chaperone Genes by ATF6-alpha
evidence: Evidence159
xref: UnificationXref1121
xref: RelationshipXref125
xref: UnificationXref1122
pathway order: PathwayStep150
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

alpha-ketoadipate
type: SmallMolecule
entity reference: 2-Oxoadipate
data source: Provenance1
name: 2-oxoadipic acid
name: alpha-ketoadipic acid
xref: UnificationXref3431
xref: UnificationXref3432
cellular location: GO:0005759
comment: Reactome DB_ID: 70951
display name: 2-oxoadipate

Activation of Chaperone Genes by XBP1(S)
type: Pathway
data source: Provenance1
pathway component: Expression of DNAJB9
evidence: Evidence161
xref: UnificationXref1128
xref: UnificationXref1127
pathway order: PathwayStep152
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

glutaryl-CoA
type: SmallMolecule
entity reference: Glutaryl-CoA [ChEBI:15524]
data source: Provenance1
xref: UnificationXref3445
xref: UnificationXref3444
cellular location: GO:0005759
comment: Reactome DB_ID: 70955
display name: GL-CoA

3-(4-Hydroxyphenyl)pyruvate
type: SmallMolecule
entity reference: CHEBI:15999
data source: Provenance1
name: p-Hydroxyphenylpyruvic acid
xref: UnificationXref3451
xref: UnificationXref3452
cellular location: GO:0005829
comment: Reactome DB_ID: 31365
display name: 4-Hydroxyphenylpyruvate

3-Anthraniloyl-L-alanine
type: SmallMolecule
entity reference: L-Kynurenine [ChEBI:16946]
data source: Provenance1
name: L-Kynurenine
xref: UnificationXref3471
xref: UnificationXref3470
cellular location: GO:0005759
comment: Reactome DB_ID: 893607
display name: L-KYN

trans-Oct-2-enoyl-CoA [ChEBI:27537]
type: SmallMoleculeReference
name: trans-Oct-2-enoyl-CoA
xref: UnificationXref1922

4-(2-aminophenyl)-2,4-dioxobutanoic acid
type: SmallMolecule
entity reference: CHEBI:17442
data source: Provenance1
xref: UnificationXref3474
xref: UnificationXref3473
cellular location: GO:0005759
comment: Reactome DB_ID: 893617

Carbamoyl phosphate
type: SmallMolecule
entity reference: Carbamoyl phosphate [ChEBI:17672]
data source: Provenance1
xref: UnificationXref3480
xref: UnificationXref3481
cellular location: GO:0005759
comment: Reactome DB_ID: 29676
display name: CAP

(S)-2,5-Diaminopentanoate
type: SmallMolecule
entity reference: (S)-2,5-Diaminopentanoate
data source: Provenance1
name: (S)-2,5-Diaminopentanoic acid
name: (S)-2,5-diaminovaleric acid
name: L-Ornithine
xref: UnificationXref3484
xref: UnificationXref3483
cellular location: GO:0005759
comment: Reactome DB_ID: 113585
display name: L-Orn

2-Amino-5-ureidovaleric acid
type: SmallMolecule
entity reference: CHEBI:16349
data source: Provenance1
name: L-Citrulline
xref: UnificationXref3486
xref: UnificationXref3487
cellular location: GO:0005759
comment: Reactome DB_ID: 113567
display name: L-Cit

2-Amino-5-ureidovaleric acid
type: SmallMolecule
entity reference: CHEBI:16349
data source: Provenance1
name: L-Citrulline
xref: UnificationXref3497
xref: UnificationXref3496
cellular location: GO:0005829
comment: Reactome DB_ID: 29968
display name: L-Cit

http://identifiers.org/pubmed/16460286
type: PublicationXref
id: 16460286
author: Clapham, David E
author: Ramsey, I Scott
author: Delling, Markus
db: Pubmed
title: An introduction to TRP channels
source: Annu. Rev. Physiol. 68:619-47
year: 2006

N(omega)-(L-Arginino)succinate
type: SmallMolecule
entity reference: L-Argininosuccinate
data source: Provenance1
name: L-Argininosuccinic acid
name: N-(L-Arginino)succinate
name: L-Arginosuccinic acid
xref: UnificationXref3500
xref: UnificationXref3499
cellular location: GO:0005829
comment: Reactome DB_ID: 34575
display name: L-Argininosuccinate

UnificationXref3377
type: UnificationXref
id: REACT_141849
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141849.5

UnificationXref3378
type: UnificationXref
id: 4233335
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233335

UnificationXref3375
type: UnificationXref
id: REACT_154752
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154752.3

4-Aminosalicylate
type: SmallMoleculeReference
name: 4-Aminosalicylic acid
name: 4-Aminosalicylate [ChEBI:1789]
xref: UnificationXref3764

UnificationXref3376
type: UnificationXref
id: 4233490
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233490

Pyridoxamine phosphate
type: SmallMolecule
entity reference: CHEBI:18335
data source: Provenance1
xref: UnificationXref3188
xref: UnificationXref3189
cellular location: GO:0005829
comment: Reactome DB_ID: 965146
display name: PXAP

UnificationXref3379
type: UnificationXref
id: REACT_90860
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90860.9

Pyridoxamine
type: SmallMolecule
entity reference: PM
data source: Provenance1
xref: UnificationXref3185
xref: UnificationXref3186
cellular location: GO:0005829
comment: Reactome DB_ID: 964945
display name: PXA

Pyridoxal
type: SmallMolecule
entity reference: CHEBI:17310
data source: Provenance1
xref: UnificationXref3174
xref: UnificationXref3175
cellular location: GO:0005829
comment: Reactome DB_ID: 965131
display name: PXL

UnificationXref3370
type: UnificationXref
id: P12281
db: UniProt

UnificationXref3373
type: UnificationXref
id: 4232877
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232877

UnificationXref3374
type: UnificationXref
id: 4232879
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232879

http://identifiers.org/pubmed/16011460
type: PublicationXref
id: 16011460
author: Harrison, EH
db: Pubmed
title: Mechanisms of digestion and absorption of dietary vitamin A
source: Annu Rev Nutr 25:87-103
year: 2005

UnificationXref3371
type: UnificationXref
id: 4232875
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232875

UnificationXref3372
type: UnificationXref
id: 4232876
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232876

1-thioglycine
type: SequenceModificationVocabulary
xref: UnificationXref3352

Nicotinamide
type: SmallMolecule
entity reference: CHEBI:17154
data source: Provenance1
xref: UnificationXref3242
xref: UnificationXref3241
cellular location: GO:0005829
comment: Reactome DB_ID: 197277
display name: NAM

Nicotinate
type: SmallMolecule
entity reference: CHEBI:15940
data source: Provenance1
name: Nicotinic acid
name: Niacin
xref: UnificationXref3245
xref: UnificationXref3244
cellular location: GO:0005829
comment: Reactome DB_ID: 197230
display name: NCA

Quinolinate
type: SmallMolecule
entity reference: quinolinate(1-)
data source: Provenance1
xref: UnificationXref3227
xref: UnificationXref3226
cellular location: GO:0005829
comment: Reactome DB_ID: 197238
display name: QUIN

Nicotinate D-ribonucleotide
type: SmallMolecule
entity reference: beta-Nicotinate D-ribonucleotide
data source: Provenance1
xref: UnificationXref3230
xref: UnificationXref3229
cellular location: GO:0005829
comment: Reactome DB_ID: 197220

Oxygen
type: SmallMolecule
entity reference: CHEBI:15379
data source: Provenance1
xref: UnificationXref3201
xref: UnificationXref3200
cellular location: GO:0005829
comment: Reactome DB_ID: 29368
display name: O2

Mn(III)
type: SmallMolecule
entity reference: CHEBI:18291
data source: Provenance1
name: Mn(II)
name: Manganese
xref: UnificationXref3218
xref: UnificationXref3217
cellular location: GO:0005829
comment: Reactome DB_ID: 29418
display name: Mn2+

Pyridoxine
type: SmallMolecule
entity reference: Pyridoxol
data source: Provenance1
xref: UnificationXref3194
xref: UnificationXref3193
cellular location: GO:0005829
comment: Reactome DB_ID: 965053
display name: PDX

Pyridoxine phosphate
type: SmallMolecule
entity reference: CHEBI:28803
data source: Provenance1
xref: UnificationXref3197
xref: UnificationXref3196
cellular location: GO:0005829
comment: Reactome DB_ID: 964952
display name: PDXP

UnificationXref3364
type: UnificationXref
id: CHEBI:36264
db: ChEBI

L-Glutamine
type: SmallMoleculeReference
name: L-Glutamine [ChEBI:18050]
name: L-2-Aminoglutaramic acid
xref: UnificationXref153

UnificationXref3365
type: UnificationXref
id: 947561
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=947561

UnificationXref3366
type: UnificationXref
id: REACT_27003
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27003.2

http://identifiers.org/pubmed/17956313
type: PublicationXref
id: 17956313
author: Herbert, TP
db: Pubmed
title: PERK in the life and death of the pancreatic beta-cell
source: Biochem Soc Trans 35:1205-7
year: 2007

UnificationXref3367
type: UnificationXref
id: CHEBI:25372
db: ChEBI

UniProt:P0AGB0
type: ProteinReference
xref: UnificationXref3418
organism: BioSource1

UnificationXref3368
type: UnificationXref
id: 947539
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=947539

THF-polyglutamate
type: SmallMolecule
entity reference: THF-polyglutamate
data source: Provenance1
xref: UnificationXref3264
xref: UnificationXref3265
cellular location: GO:0005829
comment: Reactome DB_ID: 197969
display name: THFPG

UnificationXref3369
type: UnificationXref
id: REACT_25424
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25424.1

Folate
type: SmallMolecule
entity reference: Pteroylglutamic acid
data source: Provenance1
xref: UnificationXref3256
xref: UnificationXref3257
cellular location: GO:0005829
comment: Reactome DB_ID: 197965
display name: FOLA

UnificationXref3360
type: UnificationXref
id: REACT_26842
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26842.2

UnificationXref3361
type: UnificationXref
id: 4232897
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232897

http://identifiers.org/pubmed/7678419
type: PublicationXref
id: 7678419
author: Smith, BL
author: Agre, P
author: Knepper, MA
author: Christensen, EI
author: Nielsen, S
db: Pubmed
title: CHIP28 water channels are localized in constitutively water-permeable segments of the nephron
source: J Cell Biol 120:371-83
year: 1993

UnificationXref3362
type: UnificationXref
id: 4232899
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232899

UnificationXref3363
type: UnificationXref
id: REACT_127438
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127438.5

Signaling by EGFR in Cancer
type: Pathway
data source: Provenance1
pathway component: REACT 131807.5
evidence: Evidence193
xref: UnificationXref1274
xref: UnificationXref1275
pathway order: PathwayStep180
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

5-methyltetrahydrofolate
type: SmallMolecule
entity reference: 5-Methyltetrahydrofolate
data source: Provenance1
xref: UnificationXref3271
xref: UnificationXref3272
cellular location: GO:0005829
comment: Reactome DB_ID: 200665
display name: MTHF

http://identifiers.org/pubmed/9693067
type: PublicationXref
id: 9693067
author: Bader, B
author: Löffler, M
author: Fries, M
author: Knecht, W
db: Pubmed
title: Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase.
source: Protein Expr Purif 13:414-22
year: 1998

http://identifiers.org/pubmed/16495223
type: PublicationXref
id: 16495223
author: Bowcock, A
author: Frolov, A
author: Han, X
author: Gale, SE
author: Schaffer, JE
author: Ory, DS
author: Bickel, PE
author: Cao, L
db: Pubmed
title: A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation
source: J Biol Chem 281:11082-9
year: 2006

UniProt:P0A9M2
type: ProteinReference
xref: UnificationXref2826
organism: BioSource1

5,10-methenylTHF polyglutamate
type: SmallMolecule
entity reference: CHEBI:65049
data source: Provenance1
name: 5,10-methenyltetrahydrofolate polyglutamate
xref: UnificationXref3294
xref: UnificationXref3293
cellular location: GO:0005829
comment: Reactome DB_ID: 200640
display name: 5,10-MTHFPG

5,10-methyleneTHF polyglutamate
type: SmallMolecule
entity reference: 5,10-methylenetetrahydrofolate polyglutamate
data source: Provenance1
name: 5,10-methylenetetrahydrofolate polyglutamate
xref: UnificationXref3299
xref: UnificationXref3298
cellular location: GO:0005829
comment: Reactome DB_ID: 200739
display name: 5,10-MetTHFPG

S-adenosylmethionine
type: SmallMolecule
entity reference: CHEBI:15414
data source: Provenance1
name: S-adenosyl-L-methionine
xref: UnificationXref3314
xref: UnificationXref3313
cellular location: GO:0005829
comment: Reactome DB_ID: 71284
display name: AdoMet

5'-Deoxyadenosine
type: SmallMolecule
entity reference: CHEBI:17319
data source: Provenance1
xref: UnificationXref3317
xref: UnificationXref3316
cellular location: GO:0005829
comment: Reactome DB_ID: 947703
display name: dADE

http://identifiers.org/pubmed/9829975
type: PublicationXref
id: 9829975
author: Klaerke, DA
author: Zeuthen, T
author: Meinild, AK
db: Pubmed
title: Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5
source: J Biol Chem 273:32446-51
year: 1998

5-methyltetrahydrofolate polyglutamate
type: SmallMolecule
entity reference: CHEBI:63907
data source: Provenance1
xref: UnificationXref3275
xref: UnificationXref3274
cellular location: GO:0005829
comment: Reactome DB_ID: 174404
display name: MTHFPG

5,6,7,8-tetrahydrofolate
type: SmallMolecule
entity reference: 5,6,7,8-Tetrahydrofolate
data source: Provenance1
name: Tetrahydrofolate
name: tetrahydrofolic acid
xref: UnificationXref3278
xref: UnificationXref3279
cellular location: GO:0005759
comment: Reactome DB_ID: 200671
display name: THF

THF-polyglutamate
type: SmallMolecule
entity reference: THF-polyglutamate
data source: Provenance1
xref: UnificationXref3281
xref: UnificationXref3280
cellular location: GO:0005759
comment: Reactome DB_ID: 200679
display name: THFPG

10-formyltetrahydrofolate polyglutamate
type: SmallMolecule
entity reference: CHEBI:28010
data source: Provenance1
name: 10-Formyl-THF polyglutamate
xref: UnificationXref3286
xref: UnificationXref3285
cellular location: GO:0005829
comment: Reactome DB_ID: 111353
display name: 10-FTHFPG

UnificationXref3396
type: UnificationXref
id: REACT_131818
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131818.5

UnificationXref3395
type: UnificationXref
id: 4232733
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232733

UnificationXref3394
type: UnificationXref
id: 4232731
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232731

UnificationXref3393
type: UnificationXref
id: 4232730
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232730

UnificationXref3392
type: UnificationXref
id: 4232729
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232729

UnificationXref3391
type: UnificationXref
id: 4232728
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232728

UnificationXref3390
type: UnificationXref
id: 4232727
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232727

2'-Deoxycytidine diphosphate
type: SmallMolecule
entity reference: CHEBI:28846
data source: Provenance1
name: 2'-deoxycytidine 5'-diphosphate
xref: UnificationXref3072
xref: UnificationXref3073
cellular location: GO:0005829
comment: Reactome DB_ID: 110091
display name: dCDP

UDPglucose
type: SmallMoleculeReference
name: UDP-D-glucose
name: UDPglucose [ChEBI:18066]
name: UDP-glucose
xref: UnificationXref1657

2'-deoxyuridine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:28850
data source: Provenance1
xref: UnificationXref3076
xref: UnificationXref3075
cellular location: GO:0005829
comment: Reactome DB_ID: 110093
display name: dUDP

dADP, dGDP, dCDP, dUDP
type: SmallMolecule
data source: Provenance1
member physical entity: 2'-deoxyadenosine 5'-diphosphate
member physical entity: 2'-deoxyguanosine 5'-diphosphate
member physical entity: 2'-deoxyuridine 5'-diphosphate
member physical entity: 2'-Deoxycytidine diphosphate
xref: UnificationXref3077
xref: UnificationXref3078
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 499933

2'-deoxyadenosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:16174
data source: Provenance1
xref: UnificationXref3069
xref: UnificationXref3070
cellular location: GO:0005829
comment: Reactome DB_ID: 110090
display name: dADP

UnificationXref3399
type: UnificationXref
id: 4231572
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231572

UnificationXref3398
type: UnificationXref
id: REACT_5132
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5132.2

iron (ferric)
type: SmallMolecule
entity reference: CHEBI:29034
data source: Provenance1
xref: UnificationXref3083
xref: UnificationXref3084
cellular location: GO:0005829
comment: Reactome DB_ID: 111736
display name: Fe3+

UnificationXref3397
type: UnificationXref
id: 29642
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29642

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: ADP [ChEBI:16761]
data source: Provenance1
xref: UnificationXref3092
xref: UnificationXref3091
cellular location: nucleoplasm
comment: Reactome DB_ID: 113582
display name: ADP

ADP, GDP, CDP, UDP
type: SmallMolecule
data source: Provenance1
member physical entity: uridine 5'-diphosphate
member physical entity: GDP
member physical entity: cytidine 5'-diphosphate
member physical entity: Adenosine 5'-diphosphate
xref: UnificationXref3099
xref: UnificationXref3100
cellular location: nucleoplasm
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 499944

UniProt:P77646
type: ProteinReference
xref: UnificationXref2284
organism: BioSource1

UniProt:P31448
type: ProteinReference
xref: UnificationXref459
organism: BioSource1

UniProt:P31447
type: ProteinReference
xref: UnificationXref1346
organism: BioSource1

dADP, dGDP, dCDP, dUDP
type: SmallMolecule
data source: Provenance1
member physical entity: 2'-deoxyuridine 5'-diphosphate
member physical entity: 2'-deoxyadenosine 5'-diphosphate
member physical entity: 2'-deoxycytidine 5'-diphosphate
member physical entity: 2'-deoxyguanosine 5'-diphosphate
xref: UnificationXref3109
xref: UnificationXref3110
cellular location: nucleoplasm
comment: Reactome DB_ID: 499939
comment: Converted from EntitySet in Reactome

uridine 5'-diphosphate
type: SmallMolecule
entity reference: UDP
data source: Provenance1
name: U5DP
xref: UnificationXref3097
xref: UnificationXref3098
cellular location: nucleoplasm
comment: Reactome DB_ID: 111814
display name: UDP

cytidine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:17239
data source: Provenance1
xref: UnificationXref3095
xref: UnificationXref3096
cellular location: nucleoplasm
comment: Reactome DB_ID: 111809
display name: CDP

GDP
type: SmallMolecule
entity reference: CHEBI:17552
data source: Provenance1
xref: UnificationXref3094
xref: UnificationXref3093
cellular location: nucleoplasm
comment: Reactome DB_ID: 111349

extracellular region
type: CellularLocationVocabulary
xref: UnificationXref1

UnificationXref3383
type: UnificationXref
id: REACT_82808
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82808.9

UnificationXref3382
type: UnificationXref
id: 4231559
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231559

UnificationXref3385
type: UnificationXref
id: REACT_93870
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93870.9

UnificationXref3384
type: UnificationXref
id: 4231568
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231568

UnificationXref3381
type: UnificationXref
id: REACT_97734
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97734.9

UnificationXref3380
type: UnificationXref
id: 4233336
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233336

2'-deoxyadenosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:16174
data source: Provenance1
xref: UnificationXref3102
xref: UnificationXref3101
cellular location: nucleoplasm
comment: Reactome DB_ID: 111783
display name: dADP

2'-deoxyguanosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:28862
data source: Provenance1
xref: UnificationXref3103
xref: UnificationXref3104
cellular location: nucleoplasm
comment: Reactome DB_ID: 111785
display name: dGDP

2'-deoxycytidine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:28846
data source: Provenance1
xref: UnificationXref3105
xref: UnificationXref3106
cellular location: nucleoplasm
comment: Reactome DB_ID: 111784
display name: dCDP

2'-deoxyuridine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:28850
data source: Provenance1
xref: UnificationXref3108
xref: UnificationXref3107
cellular location: nucleoplasm
comment: Reactome DB_ID: 111786
display name: dUDP

UnificationXref3387
type: UnificationXref
id: 31339
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31339

UnificationXref3386
type: UnificationXref
id: CHEBI:17232
db: ChEBI

UnificationXref3389
type: UnificationXref
id: P07004
db: UniProt

UnificationXref3388
type: UnificationXref
id: REACT_3509
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3509.2

iron (ferrous)
type: SmallMolecule
entity reference: CHEBI:18248
data source: Provenance1
name: Fe(II)
xref: UnificationXref3113
xref: UnificationXref3112
cellular location: nucleoplasm
comment: Reactome DB_ID: 111793
display name: Fe2+

2'-deoxyinosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:28807
data source: Provenance1
xref: UnificationXref3142
xref: UnificationXref3143
cellular location: GO:0005829
comment: Reactome DB_ID: 2509835
display name: dITP

inosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:16039
data source: Provenance1
xref: UnificationXref3133
xref: UnificationXref3134
cellular location: GO:0005829
comment: Reactome DB_ID: 2509836
display name: ITP

xanthosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:10049
data source: Provenance1
xref: UnificationXref3152
xref: UnificationXref3151
cellular location: GO:0005829
comment: Reactome DB_ID: 2509848
display name: XTP

deoxyinosinic acid
type: SmallMolecule
entity reference: CHEBI:28806
data source: Provenance1
name: 2'-deoxyinosine 5'-monophosphate
xref: UnificationXref3146
xref: UnificationXref3145
cellular location: GO:0005829
comment: Reactome DB_ID: 109330
display name: dIMP

4' phosphopantetheine
type: SmallMolecule
entity reference: Phosphopantetheine
data source: Provenance1
xref: UnificationXref3163
xref: UnificationXref3162
cellular location: GO:0005829
comment: Reactome DB_ID: 196767
display name: PPANT

Phosphopantothenoylcysteine
type: SmallMolecule
entity reference: (R)-4'-Phosphopantothenoyl-L-cysteine [ChEBI:328]
data source: Provenance1
xref: UnificationXref3160
xref: UnificationXref3159
cellular location: GO:0005829
comment: Reactome DB_ID: 196834
display name: PPC

http://identifiers.org/pubmed/14973138
type: PublicationXref
id: 14973138
author: Morrison, L
author: Thuerauf, DJ
author: Glembotski, CC
db: Pubmed
title: Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction
source: J Biol Chem 279:21078-84
year: 2004

thymidylic acid
type: SmallMolecule
entity reference: CHEBI:17013
data source: Provenance1
name: thymidine 5'-monophosphate
xref: UnificationXref2994
xref: UnificationXref2993
cellular location: extracellular region
comment: Reactome DB_ID: 109292
display name: TMP

CMP, TMP. UMP
type: SmallMolecule
data source: Provenance1
member physical entity: uridine 5'-monophosphate
member physical entity: cytidine 5'-monophosphate
member physical entity: thymidylic acid
xref: UnificationXref2998
xref: UnificationXref2997
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500316

cytidine 5'-monophosphate
type: SmallMolecule
entity reference: CHEBI:17361
data source: Provenance1
name: cytidylic acid
xref: UnificationXref2991
xref: UnificationXref2992
cellular location: extracellular region
comment: Reactome DB_ID: 109289
display name: CMP

CMP, UMP
type: SmallMolecule
data source: Provenance1
member physical entity: Cytidine-5'-monophosphate
member physical entity: uridine 5'-monophosphate
xref: UnificationXref2979
xref: UnificationXref2980
cellular location: GO:0005829
comment: Reactome DB_ID: 500761
comment: Converted from EntitySet in Reactome

Cytidine-5'-monophosphate
type: SmallMolecule
entity reference: CHEBI:17361
data source: Provenance1
name: cytidine 5'-monophosphate
name: cytidylic acid
xref: UnificationXref2978
xref: UnificationXref2977
cellular location: GO:0005829
comment: Reactome DB_ID: 109395
display name: CMP

2-Deoxyuridine
type: SmallMolecule
entity reference: CHEBI:16450
data source: Provenance1
name: 2'-deoxyuridine
name: Deoxyuridine
xref: UnificationXref2967
xref: UnificationXref2966
cellular location: GO:0005829
comment: Reactome DB_ID: 109383
display name: dU

cytidine, uridine
type: SmallMolecule
data source: Provenance1
member physical entity: SmallMolecule102
member physical entity: SmallMolecule100
xref: UnificationXref2976
xref: UnificationXref2975
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500759

Riboflavin-5-phosphate
type: SmallMolecule
entity reference: FMN [ChEBI:17621]
data source: Provenance1
name: Flavin mononucleotide
xref: UnificationXref3010
xref: UnificationXref3011
cellular location: GO:0005829
comment: Reactome DB_ID: 73524
display name: FMN

2,4(1H,3H)-Pyrimidinedione, dihydro-
type: SmallMolecule
entity reference: CHEBI:15901
data source: Provenance1
name: Dihydrouracile
name: 5,6-Dihydrouracil
name: 5,6-Dihydro-2,4-dihydroxypyrimidine
name: dihydrouracil
xref: UnificationXref3005
xref: UnificationXref3006
cellular location: GO:0005829
comment: Reactome DB_ID: 73584
display name: Hydrouracil

cytidine, thymidine, uridine
type: SmallMolecule
data source: Provenance1
member physical entity: cytidine
member physical entity: uridine
member physical entity: thymidine
xref: UnificationXref2999
xref: UnificationXref3000
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500318

uridine 5'-monophosphate
type: SmallMolecule
entity reference: Uridine 5'-monophosphate
data source: Provenance1
name: uridylic acid
name: U5MP
xref: UnificationXref2996
xref: UnificationXref2995
cellular location: extracellular region
comment: Reactome DB_ID: 109280
display name: UMP

http://identifiers.org/pubmed/20162368
type: PublicationXref
id: 20162368
author: Ueki, I
author: Stipanuk, MH
db: Pubmed
title: Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur
source: J Inherit Metab Dis 34:17-32
year: 2011

UniProt:P0A9H1
type: ProteinReference
xref: UnificationXref275
organism: BioSource1

http://identifiers.org/pubmed/12684532
type: PublicationXref
id: 12684532
author: Kabashima, T
author: Uyeda, K
author: Wadzinski, BE
author: Kawaguchi, T
db: Pubmed
title: Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver
source: Proc Natl Acad Sci U S A 100:5107-12
year: 2003

(d)GMP
type: SmallMolecule
data source: Provenance1
member physical entity: deoxyguanylic acid
member physical entity: SmallMolecule448
xref: UnificationXref3048
xref: UnificationXref3049
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500071

deoxyguanylic acid
type: SmallMolecule
entity reference: CHEBI:16192
data source: Provenance1
name: 2'-deoxyguanosine 5'-monophosphate
xref: UnificationXref3047
xref: UnificationXref3046
cellular location: GO:0005829
comment: Reactome DB_ID: 109327
display name: dGMP

Flavin adenine dinucleotide
type: SmallMolecule
entity reference: CHEBI:16238
data source: Provenance1
xref: UnificationXref3012
xref: UnificationXref3013
cellular location: GO:0005829
comment: Reactome DB_ID: 29386
display name: FAD

beta-Ureidopropionic acid
type: SmallMolecule
entity reference: CHEBI:18261
data source: Provenance1
name: 3-Ureidopropanoate
name: N-Carbamoyl-beta-alanine
name: 3-Ureidopropionate
xref: UnificationXref3019
xref: UnificationXref3018
cellular location: GO:0005829
comment: Reactome DB_ID: 73588
display name: UPROP

5,6-Dihydrothymine
type: SmallMolecule
entity reference: Dihydrothymine
data source: Provenance1
name: 5,6-Dihydro-5-methyluracil
xref: UnificationXref3026
xref: UnificationXref3027
cellular location: GO:0005829
comment: Reactome DB_ID: 73541
display name: Dihydrothymine

3-Ureidoisobutyrate
type: SmallMolecule
entity reference: 3-Ureidoisobutyrate
data source: Provenance1
name: 3-ureidoisobutyric acid
xref: UnificationXref3032
xref: UnificationXref3031
cellular location: GO:0005829
comment: Reactome DB_ID: 73617
display name: UIBA

ADP, GDP, CDP, UDP
type: SmallMolecule
data source: Provenance1
member physical entity: uridine 5'-diphosphate
member physical entity: Adenosine 5'-diphosphate
member physical entity: Cytidine diphosphate
member physical entity: SmallMolecule464
xref: UnificationXref3066
xref: UnificationXref3067
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 499930

2'-deoxyguanosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:28862
data source: Provenance1
xref: UnificationXref3052
xref: UnificationXref3051
cellular location: GO:0005829
comment: Reactome DB_ID: 110092
display name: dGDP

uridine 5'-diphosphate
type: SmallMolecule
entity reference: UDP
data source: Provenance1
xref: UnificationXref3064
xref: UnificationXref3065
cellular location: GO:0005829
comment: Reactome DB_ID: 110096
display name: UDP

Cytidine diphosphate
type: SmallMolecule
entity reference: CHEBI:17239
data source: Provenance1
name: cytidine 5'-diphosphate
xref: UnificationXref3063
xref: UnificationXref3062
cellular location: GO:0005829
comment: Reactome DB_ID: 110094
display name: CDP

(d)GDP
type: SmallMolecule
data source: Provenance1
member physical entity: 2'-deoxyguanosine 5'-diphosphate
member physical entity: SmallMolecule464
xref: UnificationXref3053
xref: UnificationXref3054
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500077

http://identifiers.org/pubmed/2347593
type: PublicationXref
id: 2347593
author: Hoffmann, J W
author: Bachinsky, D R
author: Powell, P P
author: Kyle, J W
author: Shipley, J M
author: Miller, R D
author: Sly, W S
db: Pubmed
title: Cloning and characterization of the human beta-glucuronidase gene
source: Genomics 7:280-3
year: 1990

http://identifiers.org/pubmed/10583946
type: PublicationXref
id: 10583946
author: Wood, RD
author: Lindahl, T
db: Pubmed
title: Quality control by DNA repair
source: Science 286:1897-905
year: 1999

P0ADE6
type: Protein
entity reference: UniProt:P0ADE6
data source: Provenance1
xref: UnificationXref2629
cellular location: intracellular
comment: Reactome DB_ID: 4232763

UnificationXref1844
type: UnificationXref
id: P76503
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AEP9
data source: Provenance1
name: D-2-hydroxyglutarate dehydrogenase
name: P0AEP9
xref: UnificationXref2614
feature: FragmentFeature244
cellular location: intracellular
comment: Reactome DB_ID: 4232768
display name: D2HGDH

UnificationXref1843
type: UnificationXref
id: 4231979
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231979

UnificationXref1846
type: UnificationXref
id: 4231983
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231983

UnificationXref1845
type: UnificationXref
id: 4231982
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231982

Asparagine N-linked glycosylation
type: Pathway
data source: Provenance1
pathway component: REACT 132295.5
evidence: Evidence150
xref: UnificationXref1072
xref: RelationshipXref122
xref: UnificationXref1071
pathway order: PathwayStep141
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0A836
data source: Provenance1
name: Succinyl-CoA synthetase, betaG chain
name: P0A836
xref: UnificationXref2591
feature: FragmentFeature241
cellular location: intracellular
comment: Reactome DB_ID: 4231763
display name: SUCLG2

UnificationXref1848
type: UnificationXref
id: REACT_129585
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129585.5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AGE9
data source: Provenance1
name: SUCLG1(28-333)
name: Succinyl-CoA synthetase, alpha-chain
xref: UnificationXref2589
feature: FragmentFeature240
cellular location: intracellular
comment: Reactome DB_ID: 4231617
display name: P0AGE9

UnificationXref1847
type: UnificationXref
id: 4231990
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231990

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P37339
data source: Provenance1
name: L-2-hydroxyglutarate dehydrogenase
name: P37339
xref: UnificationXref2607
feature: FragmentFeature243
cellular location: intracellular
comment: Reactome DB_ID: 4232777
display name: L2HGDH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0A836
data source: Provenance1
name: Succinyl-CoA synthetase, betaA chain
name: P0A836
xref: UnificationXref2595
feature: FragmentFeature242
cellular location: intracellular
comment: Reactome DB_ID: 4231620
display name: SUCLA2

UnificationXref1849
type: UnificationXref
id: CHEBI:15491
db: ChEBI

uracil
type: SmallMolecule
entity reference: CHEBI:17568
data source: Provenance1
xref: UnificationXref2961
xref: UnificationXref2962
cellular location: GO:0005829
comment: Reactome DB_ID: 83962
display name: Ura

thymidine, deoxyuridine
type: SmallMolecule
data source: Provenance1
member physical entity: 2-Deoxyuridine
member physical entity: SmallMolecule101
xref: UnificationXref2969
xref: UnificationXref2968
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500444

thymine
type: SmallMolecule
entity reference: Thymine
data source: Provenance1
xref: UnificationXref2960
xref: UnificationXref2959
cellular location: GO:0005829
comment: Reactome DB_ID: 83960
display name: Thy

Transport of vitamins, nucleosides, and related molecules
type: Pathway
data source: Provenance1
pathway component: REACT 106011.9
evidence: Evidence89
xref: UnificationXref627
xref: UnificationXref626
pathway order: PathwayStep82
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

thymine, uracil
type: SmallMolecule
data source: Provenance1
member physical entity: uracil
member physical entity: thymine
xref: UnificationXref2963
xref: UnificationXref2964
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500438

Deoxythymidylic acid
type: SmallMolecule
entity reference: CHEBI:17013
data source: Provenance1
name: dTMP
name: thymidylic acid
name: Thymidylate
name: 5'-Thymidylic acid
name: Thymidine 5'-phosphate
name: Deoxythymidine 5'-phosphate
name: thymidine 5'-monophosphate
name: Thymidine monophosphate
xref: UnificationXref2952
xref: UnificationXref2953
cellular location: GO:0005829
comment: Reactome DB_ID: 109366
display name: TMP

7,8-Dihydrofolic acid
type: SmallMolecule
entity reference: Dihydrofolate [ChEBI:15633]
data source: Provenance1
name: Dihydrofolic acid
name: Dihydrofolate
name: 7,8-Dihydrofolate
xref: UnificationXref2949
xref: UnificationXref2950
cellular location: GO:0005829
comment: Reactome DB_ID: 73604
display name: DHF

2'-Deoxyuridine 5'-phosphate
type: SmallMolecule
entity reference: 2'-Deoxyuridine 5'-phosphate
data source: Provenance1
name: Deoxyuridine monophosphate
name: Deoxyuridine 5'-phosphate
name: 2'-deoxyuridine 5'-monophosphate
name: deoxyuridylic acid
xref: UnificationXref2946
xref: UnificationXref2947
cellular location: GO:0005829
comment: Reactome DB_ID: 109382
display name: dUMP

2'-Deoxyuridine 5'-phosphate
type: SmallMolecule
entity reference: 2'-Deoxyuridine 5'-phosphate
data source: Provenance1
name: Deoxyuridine monophosphate
name: Deoxyuridine 5'-phosphate
name: 2'-deoxyuridine 5'-monophosphate
name: deoxyuridylic acid
xref: UnificationXref2939
xref: UnificationXref2940
cellular location: nucleoplasm
comment: Reactome DB_ID: 500742
display name: dUMP

diphosphate
type: SmallMolecule
entity reference: CHEBI:29888
data source: Provenance1
name: pyrophosphoric acid
name: pyrophosphate
xref: UnificationXref2937
xref: UnificationXref2936
cellular location: nucleoplasm
comment: Reactome DB_ID: 113541
display name: PPi

Water
type: SmallMolecule
entity reference: CHEBI:15377
data source: Provenance1
xref: UnificationXref2935
xref: UnificationXref2934
cellular location: nucleoplasm
comment: Reactome DB_ID: 113518
display name: H2O

2'-deoxyuridine 5'-triphosphate
type: SmallMolecule
entity reference: 2'-deoxyuridine 5'-triphosphate
data source: Provenance1
xref: UnificationXref2933
xref: UnificationXref2932
cellular location: nucleoplasm
comment: Reactome DB_ID: 500739
display name: dUTP

UnificationXref1840
type: UnificationXref
id: 77300
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77300

UnificationXref1841
type: UnificationXref
id: REACT_2413
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2413.1

UnificationXref1842
type: UnificationXref
id: P77399
db: UniProt

UnificationXref1857
type: UnificationXref
id: 77272
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77272

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0A887
data source: Provenance1
name: COQ5_HUMAN
name: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial ecNumber2.1.1.201/ecNumber
name: P0A887
xref: UnificationXref2507
feature: FragmentFeature235
cellular location: intracellular
comment: Reactome DB_ID: 4233249
display name: COQ5

UnificationXref1856
type: UnificationXref
id: CHEBI:15532
db: ChEBI

COQ3_HUMAN
type: Protein
entity reference: P17993
data source: Provenance1
name: Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial ecNumber2.1.1.114/ecNumber
name: Note: the coordinates are copied over from Homo sapiens.
name: P17993
name: COQ3(?-369)
xref: UnificationXref2497
feature: FragmentFeature234
cellular location: intracellular
comment: Reactome DB_ID: 4233231
display name: COQ3

UnificationXref1855
type: UnificationXref
id: REACT_3654
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3654.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P75728
data source: Provenance1
name: Ubiquinone biosynthesis monooxygenase COQ6 ecNumber1.14.13.-/ecNumber
name: COQ6_HUMAN
name: P75728
xref: UnificationXref2480
feature: FragmentFeature233
cellular location: intracellular
comment: Reactome DB_ID: 4233242
display name: COQ6

UnificationXref1854
type: UnificationXref
id: 29374
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29374

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P25535
data source: Provenance1
name: Ubiquinone biosynthesis monooxygenase COQ6 ecNumber1.14.13.-/ecNumber
name: COQ6_HUMAN
name: P25535
xref: UnificationXref2478
feature: FragmentFeature232
cellular location: intracellular
comment: Reactome DB_ID: 4233239
display name: COQ6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P25534
data source: Provenance1
name: Ubiquinone biosynthesis monooxygenase COQ6 ecNumber1.14.13.-/ecNumber
name: COQ6_HUMAN
name: P25534
xref: UnificationXref2476
feature: FragmentFeature231
cellular location: intracellular
comment: Reactome DB_ID: 4233236
display name: COQ6

Homologues of COQ6
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2481
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4233243

UnificationXref1859
type: UnificationXref
id: 4231992
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231992

Para-hydroxybenzoate--polyprenyltransferase, mitochondrial
type: Protein
entity reference: UniProt:P0AGK1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P0AGK1
name: COQ2_HUMAN
xref: UnificationXref2462
feature: FragmentFeature230
cellular location: intracellular
comment: Reactome DB_ID: 4233254
display name: COQ2

UnificationXref1858
type: UnificationXref
id: REACT_2294
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2294.2

orotidine 5'-monophosphate
type: SmallMolecule
entity reference: Orotidine 5'-phosphate [ChEBI:15842]
data source: Provenance1
name: orotidine 5'-phosphate
xref: UnificationXref2919
xref: UnificationXref2920
cellular location: GO:0005829
comment: Reactome DB_ID: 111629
display name: orotidylic acid

uridine 5'-monophosphate
type: SmallMolecule
entity reference: Uridine 5'-monophosphate
data source: Provenance1
name: Uridine monophosphate
name: uridylic acid
name: 5'Uridylic acid
xref: UnificationXref2927
xref: UnificationXref2928
cellular location: GO:0005829
comment: Reactome DB_ID: 109402
display name: UMP

UniProt:P0A959
type: ProteinReference
xref: UnificationXref3453
organism: BioSource1

5-Phosphoribose 1-diphosphate biosynthesis
type: Pathway
data source: Provenance1
name: Synthesis of cytosolic 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) from D-ribose 5-phosphate
pathway component: BiochemicalReaction142
pathway component: BiochemicalReaction141
evidence: Evidence273
xref: RelationshipXref219
xref: UnificationXref1753
xref: UnificationXref1754
pathway order: PathwayStep259
pathway order: PathwayStep258
display name: PRPP biosynthesis
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10727444
type: PublicationXref
id: 10727444
author: Furuyama, K
author: Sassa, S
db: Pubmed
title: Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia
source: J Clin Invest 105:757-64
year: 2000

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AFG3
data source: Provenance1
name: 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor
name: 2-oxoglutarate dehydrogenase E1
name: ODO1_HUMAN
name: P0AFG3
name: Alpha-ketoglutarate dehydrogenase
name: alpha-ketoglutarate dehydrogenase E1 apoenzyme
xref: UnificationXref2571
feature: FragmentFeature238
cellular location: intracellular
comment: Reactome DB_ID: 4231639
display name: OGDH

Glycine cleavage system L protein
type: Protein
entity reference: P0A9P0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P0A9P0
name: Dihydrolipoamide dehydrogenase, mitochondrial
xref: UnificationXref2577
feature: FragmentFeature239
cellular location: intracellular
comment: Reactome DB_ID: 4231649
display name: DLD

http://identifiers.org/pubmed/10828066
type: PublicationXref
id: 10828066
author: Jorgensen, R
author: Justesen, J
author: Sogaard, TM
author: Martensen, PM
author: Rossing, AB
db: Pubmed
title: Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase
source: J Biol Chem 275:16820-6
year: 2000

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A6T5
data source: Provenance1
name: P0A6T5
name: GTP cyclohydrolase 1
name: GCH1_HUMAN
xref: UnificationXref2540
feature: FragmentFeature236
cellular location: intracellular
comment: Reactome DB_ID: 4232988
display name: GCH1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AFG6
data source: Provenance1
name: alpha-ketoglutarate dehydrogenase E2
name: Dihydrolipoamide succinyltransferase
name: P0AFG6
name: Lipo-DLST
xref: UnificationXref2565
feature: FragmentFeature237
feature: ModificationFeature30
cellular location: intracellular
comment: Reactome DB_ID: 4231645
display name: DLST

UnificationXref1852
type: UnificationXref
id: 4231991
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231991

UnificationXref1853
type: UnificationXref
id: REACT_127777
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127777.5

UnificationXref1850
type: UnificationXref
id: 77302
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77302

UnificationXref1851
type: UnificationXref
id: REACT_3202
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3202.1

5-acetamido-6-formamido-3-methyluracil
type: SmallMoleculeReference
name: ChEBI:32643 5-acetamido-6-formamido-3-methyluracil
xref: UnificationXref3796

UnificationXref1869
type: UnificationXref
id: 4231987
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231987

UnificationXref1866
type: UnificationXref
id: CHEBI:27466
db: ChEBI

UnificationXref1865
type: UnificationXref
id: REACT_3421
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3421.1

UnificationXref1868
type: UnificationXref
id: REACT_5705
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5705.1

http://identifiers.org/pubmed/17309651
type: PublicationXref
id: 17309651
author: Grinberg, D
author: Vilageliu, L
author: Blanco, M
author: Santamaria, R
author: Chabas, A
db: Pubmed
title: Identification of 14 novel GLB1 mutations, including five deletions, in 19 patients with GM1 gangliosidosis from South America
source: Clin. Genet. 71:273-9
year: 2007

UnificationXref1867
type: UnificationXref
id: 77276
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77276

http://identifiers.org/pubmed/8327470
type: PublicationXref
id: 8327470
author: Murer, H
author: Stange, G
author: Biber, J
author: Sorribas, V
author: Markovich, D
author: Magagnin, S
author: Werner, A
db: Pubmed
title: Expression cloning of human and rat renal cortex Na/Pi cotransport
source: Proc Natl Acad Sci U S A 90:5979-83
year: 1993

UnificationXref1861
type: UnificationXref
id: 4233365
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233365

UnificationXref1862
type: UnificationXref
id: REACT_129172
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129172.5

UnificationXref1863
type: UnificationXref
id: CHEBI:27721
db: ChEBI

UnificationXref1864
type: UnificationXref
id: 77273
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77273

UnificationXref1860
type: UnificationXref
id: REACT_129785
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129785.5

http://identifiers.org/pubmed/8626564
type: PublicationXref
id: 8626564
author: Kimmel, R
author: Ostlund, EL
author: Sherman, WR
author: Seemayer, R
author: Gupta, S
author: Ostlund RE, Jr
db: Pubmed
title: A stereospecific myo-inositol/D-chiro-inositol transporter in HepG2 liver cells. Identification with D-chiro-[3-3H]inositol
source: J Biol Chem 271:10073-8
year: 1996

UnificationXref1879
type: UnificationXref
id: 4231985
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231985

UnificationXref1878
type: UnificationXref
id: REACT_2800
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2800.2

UnificationXref1877
type: UnificationXref
id: 77261
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77261

UnificationXref1876
type: UnificationXref
id: CHEBI:15521
db: ChEBI

http://identifiers.org/pubmed/17215883
type: PublicationXref
id: 17215883
author: Cellier, MF
author: Courville, P
author: Chaloupka, R
db: Pubmed
title: Recent progress in structure-function analyses of Nramp proton-dependent metal-ion transporters
source: Biochem Cell Biol 84:960-78
year: 2006

http://identifiers.org/pubmed/10858654
type: PublicationXref
id: 10858654
author: Kühl, Michael
author: Park, M
author: Moon, Randall T
author: Sheldahl, L C
author: Miller, J R
db: Pubmed
title: The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape
source: Trends Genet. 16:279-83
year: 2000

UnificationXref1874
type: UnificationXref
id: 4231989
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231989

UnificationXref1875
type: UnificationXref
id: REACT_125968
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125968.5

UnificationXref1872
type: UnificationXref
id: 77269
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77269

UnificationXref1873
type: UnificationXref
id: REACT_5544
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5544.1

UnificationXref1870
type: UnificationXref
id: REACT_143502
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143502.5

UnificationXref1871
type: UnificationXref
id: CHEBI:28726
db: ChEBI

Q46822
type: Protein
entity reference: Q46822
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: IDI1_HUMAN
name: Isopentenyl-diphosphate delta-isomerase 1
xref: UnificationXref2140
feature: FragmentFeature209
cellular location: intracellular
comment: Reactome DB_ID: 4232248
display name: IDI1

GPAM/GPAT2
type: Protein
data source: Provenance1
member physical entity: glycerol-3-phosphate acyltransferase 2, mitochondrial
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2170
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232996

P0AFI0
type: Protein
entity reference: UniProt:P0AFI0
data source: Provenance1
name: 2-hydroxyphytanoyl-CoA lyase
name: Note: the coordinates are copied over from Homo sapiens.
name: 2-hydroxyacyl-CoA lyase 1
xref: UnificationXref2068
feature: FragmentFeature205
cellular location: intracellular
comment: Reactome DB_ID: 4232470
display name: HACL1

UnificationXref1887
type: UnificationXref
id: 77252
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77252

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AGG2
data source: Provenance1
name: Acyl-coenzyme A thioesterase 8
name: P0AGG2
xref: UnificationXref2087
feature: FragmentFeature206
cellular location: intracellular
comment: Reactome DB_ID: 4232254
display name: ACOT8

UnificationXref1888
type: UnificationXref
id: REACT_5323
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5323.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q46911
data source: Provenance1
name: Q46911
name: Alkyldihydroxyacetonephosphate synthase, peroxisomal precursor
name: Alkyl-DHAP synthase
name: Alkylglycerone phosphate synthase
name: Alkyldihydroxyacetonephosphate synthase precursor
xref: UnificationXref2112
feature: FragmentFeature207
cellular location: intracellular
comment: Reactome DB_ID: 4231943
display name: AGPS

UnificationXref1889
type: UnificationXref
id: P76082
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A7A7
data source: Provenance1
name: Acyl- CoA:dihydroxyacetonephosphateacyltransferase
name: Glycerone-phosphate O-acyltransferase
name: DHAP-AT
name: DAP-AT
name: Dihydroxyacetone phosphate acyltransferase
name: P0A7A7
xref: UnificationXref2114
feature: FragmentFeature208
cellular location: intracellular
comment: Reactome DB_ID: 4231940
display name: GNPAT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P76459
data source: Provenance1
name: P76459
name: Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial precursor
name: Succinyl CoA:3-oxoacid CoA-transferase
name: 3-oxoacid CoA-transferase monomer
xref: UnificationXref2027
feature: FragmentFeature202
cellular location: intracellular
comment: Reactome DB_ID: 4231903
display name: OXCT1

Homologues of GPD2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P0A9C0
xref: UnificationXref2050
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232192

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P13035
data source: Provenance1
name: P13035
xref: UnificationXref2047
feature: FragmentFeature203
cellular location: intracellular
comment: Reactome DB_ID: 4232188
display name: GPD2

P0A9C0
type: Protein
entity reference: UniProt:P0A9C0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2049
feature: FragmentFeature204
cellular location: intracellular
comment: Reactome DB_ID: 4232191
display name: GPD2

UnificationXref1880
type: UnificationXref
id: REACT_139820
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139820.5

http://identifiers.org/pubmed/7951672
type: PublicationXref
id: 7951672
author: Hale, DE
author: Stanley, CA
db: Pubmed
title: Genetic disorders of mitochondrial fatty acid oxidation.
source: Curr Opin Pediatr 6:476-81
year: 1994

glycerol-3-phosphate acyltransferase 2, mitochondrial
type: Protein
entity reference: P0A7A7
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P0A7A7
xref: UnificationXref2169
feature: FragmentFeature210
cellular location: intracellular
comment: Reactome DB_ID: 4232995
display name: GPAT2

UnificationXref1882
type: UnificationXref
id: REACT_136475
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136475.5

Metformin [ChEBI:6801]
type: SmallMoleculeReference
name: Metformin
name: GLUCOPHAGE (TN)
xref: UnificationXref220

UnificationXref1881
type: UnificationXref
id: 4233364
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233364

http://identifiers.org/pubmed/14630918
type: PublicationXref
id: 14630918
author: Bruhat, A
author: Averous, J
author: Carraro, V
author: Thiel, G
author: Jousse, C
author: Fafournoux, P
db: Pubmed
title: Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation
source: J Biol Chem 279:5288-97
year: 2004

UnificationXref1884
type: UnificationXref
id: 77255
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77255

UnificationXref1883
type: UnificationXref
id: CHEBI:15471
db: ChEBI

UnificationXref1886
type: UnificationXref
id: CHEBI:27668
db: ChEBI

UnificationXref1885
type: UnificationXref
id: REACT_5571
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5571.1

http://identifiers.org/pubmed/9265629
type: PublicationXref
id: 9265629
author: Triana-Alonso, FJ
author: Petrushenko, ZM
author: Ovcharenko, GV
author: El'skaya, AV
author: Palchevskii, SS
author: Nierhaus, KH
db: Pubmed
title: Three tRNA binding sites in rabbit liver ribosomes and role of the intrinsic ATPase in 80S ribosomes from higher eukaryotes
source: Biochemistry 36:10492-7
year: 1997

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P76458
data source: Provenance1
name: P76458
name: Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial precursor
name: Succinyl CoA:3-oxoacid CoA-transferase
name: 3-oxoacid CoA-transferase monomer
xref: UnificationXref2025
feature: FragmentFeature201
cellular location: intracellular
comment: Reactome DB_ID: 4231900
display name: OXCT1

http://identifiers.org/pubmed/15523652
type: PublicationXref
id: 15523652
author: Tirone, Jamie C
author: Rosenblatt, DS
author: Leclerc, Daniel
author: Watkins, D
author: Doré, Carole
author: Lepage, Pierre
author: Dobson, C Melissa
author: Gravel, RA
author: Lerner-Ellis, Jordan P
author: Wai, Timothy
db: Pubmed
title: Mutations in the MMAA gene in patients with the cblA disorder of vitamin B12 metabolism
source: Hum. Mutat. 24:509-16
year: 2004

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AFP4
data source: Provenance1
name: 3-hydroxybutyrate dehydrogenase
name: D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (BDH) (3-hydroxybutyrate dehydrogenase)
name: D-beta-hydroxybutyrate dehydrogenase, mitochondrial
name: P0AFP4
xref: UnificationXref2013
feature: FragmentFeature200
cellular location: intracellular
comment: Reactome DB_ID: 4231893
display name: BDH1

Homologues of OXCT1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2028
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231904

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P27254
data source: Provenance1
name: MMAA_HUMAN
name: Methylmalonic aciduria type A protein, mitochondrial ecNumber3.6.-.-/ecNumber
name: P27254
xref: UnificationXref1987
feature: FragmentFeature198
cellular location: intracellular
comment: Reactome DB_ID: 4231626
display name: MMAA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P27253
data source: Provenance1
name: MCM
name: Methylmalonyl-CoA mutase, mitochondrial precursor
name: methylmalonyl-CoA mutase, apoprotein
name: MUTA_HUMAN
name: P27253
xref: UnificationXref1993
feature: FragmentFeature199
cellular location: intracellular
comment: Reactome DB_ID: 4231630
display name: MUT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P76082
data source: Provenance1
name: P76082
name: Enoyl-CoA hydratase 1
name: Short chain enoyl-CoA hydratase
name: Enoyl-CoA hydratase, mitochondrial precursor
xref: UnificationXref1890
feature: FragmentFeature196
cellular location: intracellular
comment: Reactome DB_ID: 4231973
display name: ECHS1

UnificationXref1898
type: UnificationXref
id: 77308
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77308

Mitotic G1-G1/S phases
type: Pathway
data source: Provenance1
pathway component: REACT 138886.5
evidence: Evidence188
xref: UnificationXref1245
xref: UnificationXref1244
pathway order: PathwayStep176
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1899
type: UnificationXref
id: REACT_2539
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2539.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AET8
data source: Provenance1
name: P0AET8
name: 2,4- dienoyl-CoA reductase (NADPH)
name: 2,4-dienoyl-CoA reductase, mitochondrial precursor
name: 4-enoyl-CoA reductase (NADPH)
xref: UnificationXref1977
feature: FragmentFeature197
cellular location: intracellular
comment: Reactome DB_ID: 4232010
display name: DECR1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P77399
data source: Provenance1
name: TP-alpha
name: Long chain 3-hydroxyacyl-CoA dehydrogenase
name: Long-chain enoyl-CoA hydratase
name: P77399
name: Trifunctional enzyme alpha subunit, mitochondrial precursor
name: Trifunctional enzyme alpha subunit
name: 78 kDa gastrin-binding protein
xref: UnificationXref1843
feature: FragmentFeature194
cellular location: intracellular
comment: Reactome DB_ID: 4231979
display name: HADHA

P76503
type: Protein
entity reference: UniProt:P76503
data source: Provenance1
name: Beta-ketothiolase
name: Note: the coordinates are copied over from Homo sapiens.
name: Acetyl-CoA acyltransferase
name: 3-ketoacyl-CoA thiolase
name: TP-beta
name: Trifunctional enzyme beta subunit, mitochondrial precursor
name: Trifunctional enzyme beta subunit
xref: UnificationXref1845
feature: FragmentFeature195
cellular location: intracellular
comment: Reactome DB_ID: 4231982
display name: HADHB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P26647
data source: Provenance1
name: Lysophosphatidic acid acyltransferase-beta
name: LPAAT-beta
name: 1-acylglycerol-3-phosphate O- acyltransferase 2
name: 1- AGP acyltransferase 2
name: P26647
name: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta
xref: UnificationXref1830
feature: FragmentFeature193
cellular location: intracellular
comment: Reactome DB_ID: 4231951
display name: AGPAT2

UnificationXref1893
type: UnificationXref
id: REACT_104151
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104151.9

UnificationXref1892
type: UnificationXref
id: 4231976
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231976

UnificationXref1891
type: UnificationXref
id: 4231974
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231974

UnificationXref1890
type: UnificationXref
id: 4231973
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231973

UnificationXref1897
type: UnificationXref
id: CHEBI:28493
db: ChEBI

UnificationXref1896
type: UnificationXref
id: REACT_4368
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4368.1

UnificationXref1895
type: UnificationXref
id: 77253
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77253

UnificationXref1894
type: UnificationXref
id: CHEBI:27868
db: ChEBI

Cobalt [ChEBI:3788]
type: SmallMoleculeReference
name: Cobalt
name: Co2+
xref: UnificationXref2619

http://identifiers.org/pubmed/2536298
type: PublicationXref
id: 2536298
author: Franchi, A
author: Pouysségur, Jacques
author: Sardet, C
db: Pubmed
title: Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter
source: Cell 56:271-80
year: 1989

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P06610
data source: Provenance1
name: GPX4(?-197)
name: P06610
name: Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
name: GPX4_HUMAN
xref: UnificationXref2355
feature: FragmentFeature222
cellular location: intracellular
comment: Reactome DB_ID: 4233216
display name: GPX4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P06610
data source: Provenance1
name: GPX2_HUMAN
name: P06610
name: Glutathione peroxidase 2
xref: UnificationXref2367
feature: FragmentFeature223
cellular location: intracellular
comment: Reactome DB_ID: 4233214
display name: GPX2

Homologues of ARSA(448-507)
type: Protein
data source: Provenance1
member physical entity: ARSA_HUMAN
member physical entity: P25549
xref: UnificationXref2411
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4233038

P25549
type: Protein
entity reference: UniProt:P25549
data source: Provenance1
name: ARSA_HUMAN
name: Note: the coordinates are copied over from Homo sapiens.
name: ARSA(448-507)
name: Arylsulfatase A component C
xref: UnificationXref2409
feature: FragmentFeature224
cellular location: intracellular
comment: Reactome DB_ID: 4233036
display name: ARSA-C

ARSA_HUMAN
type: Protein
entity reference: P77318
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ARSA(448-507)
name: P77318
name: Arylsulfatase A component C
xref: UnificationXref2410
feature: FragmentFeature225
cellular location: intracellular
comment: Reactome DB_ID: 4233037
display name: ARSA-C

Homologues of OxA-ARSA(19-444)
type: Protein
data source: Provenance1
member physical entity: ARSA_HUMAN
xref: UnificationXref2416
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4233035

ARSA_HUMAN
type: Protein
entity reference: UniProt:P25549
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: OxA-ARSA(19-444)
name: active ARSA-B
name: Arylsulfatase A component B
xref: UnificationXref2414
feature: FragmentFeature226
feature: ModificationFeature26
cellular location: intracellular
comment: Reactome DB_ID: 4233032
display name: P25549

ARSA_HUMAN
type: Protein
entity reference: P77318
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: OxA-ARSA(19-444)
name: active ARSA-B
name: Arylsulfatase A component B
xref: UnificationXref2415
feature: ModificationFeature27
feature: FragmentFeature227
cellular location: intracellular
comment: Reactome DB_ID: 4233034
display name: P77318

2,6-diaminohexanoic acid
type: SmallMoleculeReference
name: Lysine acid
name: L-Lysine [ChEBI:18019]
name: L-Lysine
xref: UnificationXref3821

Homologues of OxA-STS
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P25549
xref: UnificationXref2443
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4233046

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P77318
data source: Provenance1
name: Steryl-sulfatase
name: OxA-STS
name: active STS
name: STS_HUMAN
name: P77318
xref: UnificationXref2442
feature: FragmentFeature229
feature: ModificationFeature29
cellular location: intracellular
comment: Reactome DB_ID: 4233045
display name: STS

P25549
type: Protein
entity reference: UniProt:P25549
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Steryl-sulfatase
name: OxA-STS
name: active STS
name: STS_HUMAN
xref: UnificationXref2441
feature: FragmentFeature228
feature: ModificationFeature28
cellular location: intracellular
comment: Reactome DB_ID: 4233043
display name: STS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P18956
data source: Provenance1
name: GGT5_HUMAN
name: P18956
name: GGT5 heavy chain
name: GGT5(1-387)
name: GGTLA1
xref: UnificationXref2331
feature: FragmentFeature219
cellular location: plasma membrane
comment: Reactome DB_ID: 4232340
display name: GGT5

3-Oxohexanoyl-CoA [ChEBI:27648]
type: SmallMoleculeReference
name: 3-ketohexanoyl-CoA
name: 3-Oxohexanoyl-CoA
xref: UnificationXref1948

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P23830
data source: Provenance1
name: Phosphatidylglycerophosphate synthase 1
name: PGP synthase 1
name: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
name: P23830
xref: UnificationXref2203
feature: FragmentFeature213
cellular location: intracellular
comment: Reactome DB_ID: 4233004
display name: PGS1

P77646
type: Protein
entity reference: UniProt:P77646
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PGDH_HUMAN
name: 15-hydroxyprostaglandin dehydrogenase (NAD+)
xref: UnificationXref2285
feature: FragmentFeature214
cellular location: intracellular
comment: Reactome DB_ID: 4233207
display name: HPGD

P0A8K1
type: Protein
entity reference: UniProt:P0A8K1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PISDA
name: PISD(1-377)
name: Phosphatidylserine decarboxylase proenzyme Chain A
xref: UnificationXref2183
feature: FragmentFeature211
cellular location: intracellular
comment: Reactome DB_ID: 4233011
display name: PISD

P0A8K1
type: Protein
entity reference: UniProt:P0A8K1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PISD(378-409)
name: Phosphatidylserine decarboxylase proenzyme Chain B
xref: UnificationXref2187
feature: FragmentFeature212
cellular location: intracellular
comment: Reactome DB_ID: 4233012
display name: PISDB

http://identifiers.org/pubmed/17555404
type: PublicationXref
id: 17555404
author: Alp, NJ
author: Schmidt, TS
db: Pubmed
title: Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
source: Clin Sci (Lond) 113:47-63
year: 2007

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P18956
data source: Provenance1
name: GGT1_HUMAN
name: GGT1hc
name: P18956
name: GGT1 heavy chain
name: Gamma-glutamyltranspeptidase 1
name: GGT1(1-380)
xref: UnificationXref2328
feature: FragmentFeature217
cellular location: plasma membrane
comment: Reactome DB_ID: 4232338
display name: GGT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P18956
data source: Provenance1
name: GGT1lc
name: GGT1_HUMAN
name: P18956
name: GGT1(381-569)
name: Gamma-glutamyltranspeptidase 1
name: GGT1 light chain
xref: UnificationXref2329
feature: FragmentFeature218
cellular location: plasma membrane
comment: Reactome DB_ID: 4232337
display name: GGT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P76113
data source: Provenance1
name: Prostaglandin reductase 1
name: PTGR1_HUMAN
name: P76113
xref: UnificationXref2300
feature: FragmentFeature215
cellular location: intracellular
comment: Reactome DB_ID: 4233202
display name: PTGR1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P04825
data source: Provenance1
name: Leukotriene A-4 hydrolase-1
name: P04825
name: LKHA4_HUMAN
xref: UnificationXref2312
feature: FragmentFeature216
cellular location: intracellular
comment: Reactome DB_ID: 4232348
display name: LTA4H

NADP+
type: SmallMoleculeReference
name: TPN
name: NADP+ [ChEBI:18009]
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref185

L-selenocysteine residue-GPX1
type: Protein
entity reference: UniProt:P06610
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cellular glutathione peroxidase
name: GSHC_HUMAN
name: GSHPx-1
name: glutathione peroxidase monomer
name: P06610
name: Glutathione peroxidase 1
xref: UnificationXref2353
feature: FragmentFeature221
feature: ModificationFeature25
cellular location: intracellular
comment: Reactome DB_ID: 4231748
display name: GPX1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P18956
data source: Provenance1
name: GGT5 light chain
name: GGT5_HUMAN
name: P18956
name: GGT5(388-586)
xref: UnificationXref2332
feature: FragmentFeature220
cellular location: plasma membrane
comment: Reactome DB_ID: 4232341
display name: GGTLA1

http://identifiers.org/pubmed/8704248
type: PublicationXref
id: 8704248
author: Neblock, DS
author: Mascelli, MA
author: Coller, BS
author: Jordan, RE
author: Weisman, HF
author: Wagner, CL
db: Pubmed
title: Analysis of GPIIb/IIIa receptor number by quantification of 7E3 binding to human platelets
source: Blood 88:907-14
year: 1996

Cytosolic sulfonation of small molecules
type: Pathway
data source: Provenance1
pathway component: REACT 153728.3
evidence: Evidence570
xref: UnificationXref3750
xref: UnificationXref3751
xref: RelationshipXref573
pathway order: PathwayStep190
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/21325059
type: PublicationXref
id: 21325059
author: Soragni, A
author: Pham, E
author: Campioni, S
author: Tzitzilonis, C
author: Consiglio, A
author: Vilar, M
author: Loher, T
author: Mira, H
author: Masliah, E
author: Winner, B
author: Desplats, PA
author: Boyer, L
author: Jessberger, S
author: Riek, R
author: Gage, FH
author: Jappelli, R
author: Maji, SK
author: Aigner, S
author: Hetzer, C
db: Pubmed
title: In vivo demonstration that {alpha}-synuclein oligomers are toxic
source: Proc Natl Acad Sci U S A 108:4194-9
year: 2011

Peroxisomal lipid metabolism
type: Pathway
data source: Provenance1
pathway component: Beta-oxidation of very long chain fatty acids
pathway component: REACT 33669.10
pathway component: Synthesis of lysophosphatidic acid from dihydroxyacetone phosphate
pathway component: Alpha-oxidation of phytanate
evidence: Evidence334
xref: UnificationXref2131
xref: UnificationXref2132
xref: RelationshipXref258
pathway order: PathwayStep313
pathway order: PathwayStep320
pathway order: PathwayStep315
pathway order: PathwayStep317
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Glutathione synthesis and recycling
type: Pathway
data source: Provenance1
pathway component: Glutathione is hydrolyzed
evidence: Evidence577
xref: RelationshipXref577
xref: UnificationXref3853
xref: UnificationXref3852
pathway order: PathwayStep563
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/9878398
type: PublicationXref
id: 9878398
author: Mirande, M
author: Siatecka, M
author: Robinson, JC
author: Berthonneau, E
author: Quevillon, S
db: Pubmed
title: Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein
source: J Mol Biol 285:183-95
year: 1999

Chondroitin sulfate/dermatan sulfate metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 140402.5
evidence: Evidence213
xref: RelationshipXref166
xref: UnificationXref1402
xref: UnificationXref1403
pathway order: PathwayStep200
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/14392173
type: PublicationXref
id: 14392173
author: Simms, ES
author: Lieberman, I
author: Kornberg, A
db: Pubmed
title: Enzymatic synthesis and properties of 5-phosphoribosylpyrophosphate
source: J Biol Chem 215:389-402
year: 1955

http://identifiers.org/pubmed/15893380
type: PublicationXref
id: 15893380
author: Jackowski, S
author: Zhang, YM
author: Rock, CO
author: Leonardi, R
db: Pubmed
title: Coenzyme A: back in action
source: Prog Lipid Res 44:125-53
year: 2005

http://identifiers.org/pubmed/11500517
type: PublicationXref
id: 11500517
author: Su, HM
author: Moser, HW
author: Moser, AB
author: Watkins, PA
db: Pubmed
title: Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis
source: J Biol Chem 276:38115-20
year: 2001

http://identifiers.org/pubmed/8870004
type: PublicationXref
id: 8870004
author: Serizawa, A
author: Tsutsumi, Y
author: Hori, S
db: Pubmed
title: Localized amyloidosis of the seminal vesicle: identification of lactoferrin immunoreactivity in the amyloid material
source: Pathol Int 46:491-7
year: 1996

P36938
type: Protein
entity reference: UniProt:P36938
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Phosphoglucomutase
name: phosphoglucomutase 1
name: PGM1(2-562)
name: Glucose phosphomutase
xref: UnificationXref1618
feature: FragmentFeature171
cellular location: intracellular
comment: Reactome DB_ID: 4231449
display name: PGM1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P00509
data source: Provenance1
name: Aspartate aminotransferase, cytoplasmic
name: P00509
name: AATC_HUMAN
xref: UnificationXref1597
feature: FragmentFeature170
cellular location: intracellular
comment: Reactome DB_ID: 4231555
display name: GOT1

P04693
type: Protein
entity reference: UniProt:P04693
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Aspartate aminotransferase, cytoplasmic
name: AATC_HUMAN
xref: UnificationXref1596
feature: FragmentFeature169
cellular location: intracellular
comment: Reactome DB_ID: 4231552
display name: GOT1

Homologues of GOT1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P04693
xref: UnificationXref1598
cellular location: intracellular
comment: Reactome DB_ID: 4231556
comment: Converted from EntitySet in Reactome

ChEBI:16635 Met-tRNA(Met)
type: SmallMoleculeReference
name: Met-tRNA(Met)
xref: UnificationXref1013

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P00490
data source: Provenance1
name: P00490
name: Myophosphorylase
name: PXLP-PYGM
name: glycogen phosphorylase, muscle form
xref: UnificationXref1636
feature: ModificationFeature22
feature: FragmentFeature175
cellular location: intracellular
comment: Reactome DB_ID: 4231711
display name: PYGM

http://identifiers.org/pubmed/9083049
type: PublicationXref
id: 9083049
author: Lee, PT
author: Shepherd, JA
author: Tzagoloff, A
author: Myles, DC
author: Clarke, CF
author: Shtanko, A
author: Barkovich, RJ
db: Pubmed
title: Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis
source: J Biol Chem 272:9182-8
year: 1997

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AC86
data source: Provenance1
name: P0AC86
name: Myophosphorylase
name: PXLP-PYGM
name: glycogen phosphorylase, muscle form
xref: UnificationXref1635
feature: ModificationFeature21
feature: FragmentFeature174
cellular location: intracellular
comment: Reactome DB_ID: 4231707
display name: PYGM

Homologues of PXLP-PYGM
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1637
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231712

http://identifiers.org/pubmed/14730707
type: PublicationXref
id: 14730707
author: Dietrich, J
author: Rao, MS
author: Maragakis, NJ
author: Rothstein, JD
author: Xue, H
author: Wong, V
author: Mayer-Proschel, M
db: Pubmed
title: Glutamate transporter expression and function in human glial progenitors
source: Glia 45:133-43
year: 2004

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P00490
data source: Provenance1
name: PXLP-PYGB
name: P00490
name: glycogen phosphorylase, brain form
xref: UnificationXref1627
feature: ModificationFeature22
feature: FragmentFeature173
cellular location: intracellular
comment: Reactome DB_ID: 4232683
display name: PGYB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AC86
data source: Provenance1
name: PXLP-PYGB
name: P0AC86
name: glycogen phosphorylase, brain form
xref: UnificationXref1625
feature: ModificationFeature21
feature: FragmentFeature172
cellular location: intracellular
comment: Reactome DB_ID: 4232682
display name: PGYB

Homologues of PXLP-PYGB
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1628
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4232684

http://identifiers.org/pubmed/12721358
type: PublicationXref
id: 12721358
author: Veech, RL
db: Pubmed
title: A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis
source: Proc Natl Acad Sci U S A 100:5578-80
year: 2003

UniProt:P05804
type: ProteinReference
xref: UnificationXref1293
organism: BioSource1

PRP 2
type: Protein
entity reference: P0A799
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Phosphoglycerate kinase 1
name: P0A799
name: Primer recognition protein 2
xref: UnificationXref1501
feature: FragmentFeature160
cellular location: intracellular
comment: Reactome DB_ID: 4231511
display name: PGK1

[4Fe-4S](2+)
type: SmallMoleculeReference
name: ChEBI:33722 [4Fe-4S](2+)
xref: UnificationXref3326

P62707
type: Protein
entity reference: UniProt:P62707
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Phosphoglycerate mutase 2
name: Phosphoglycerate mutase isozyme M
name: bisphosphoglycerate phosphatase 2
name: bisphosphoglycerate mutase
name: Muscle-specific phosphoglycerate mutase
name: BPG-dependent PGAM 2
name: PGAM2(2-253)
name: phosphoglycerate mutase 2
xref: UnificationXref1511
feature: FragmentFeature162
cellular location: intracellular
comment: Reactome DB_ID: 4231699
display name: PGAM-M

P62707
type: Protein
entity reference: UniProt:P62707
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Phosphoglycerate mutase 1
name: bisphosphoglycerate phosphatase 1
name: PGAM1(2-254)
name: bisphosphoglycerate mutase
name: Phosphoglycerate mutase isozyme B
name: phosphoglycerate mutase 1
name: BPG-dependent PGAM 1
xref: UnificationXref1509
feature: FragmentFeature161
cellular location: intracellular
comment: Reactome DB_ID: 4231697
display name: PGAM-B

ChEBI:16624 Leu-tRNA(Leu)
type: SmallMoleculeReference
name: Leu-tRNA(Leu)
xref: UnificationXref905

http://identifiers.org/pubmed/15520807
type: PublicationXref
id: 15520807
author: Wellbrock, C
author: Karasarides, M
author: Marais, R
db: Pubmed
title: The RAF proteins take centre stage
source: Nat Rev Mol Cell Biol 5:875-85
year: 2004

P04693
type: Protein
entity reference: UniProt:P04693
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PXLP-GOT2
name: Transaminase A
name: glutamate oxaloacetate transaminase-2
name: Aspartate aminotransferase, mitochondrial precursor
name: aspartate aminotransferase, mitochondrial, apoenzyme monomer
xref: UnificationXref1585
feature: ModificationFeature19
feature: FragmentFeature167
cellular location: intracellular
comment: Reactome DB_ID: 4231562
display name: GOT2

Homologues of PXLP-GOT2
type: Protein
data source: Provenance1
member physical entity: P04693
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1588
cellular location: intracellular
comment: Reactome DB_ID: 4231565
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P00509
data source: Provenance1
name: PXLP-GOT2
name: Transaminase A
name: glutamate oxaloacetate transaminase-2
name: Aspartate aminotransferase, mitochondrial precursor
name: aspartate aminotransferase, mitochondrial, apoenzyme monomer
name: P00509
xref: UnificationXref1587
feature: ModificationFeature20
feature: FragmentFeature168
cellular location: intracellular
comment: Reactome DB_ID: 4231564
display name: GOT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AD61
data source: Provenance1
name: PKM isozyme M1
name: pyruvate kinase, M1 isozyme
name: P0AD61
name: PKM isoform 2
xref: UnificationXref1527
feature: FragmentFeature164
cellular location: intracellular
comment: Reactome DB_ID: 4231734
display name: PKM-2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A6P9
data source: Provenance1
name: 2-phospho-D-glycerate hydro-lyase
name: P0A6P9
name: Alpha enolase
name: Phosphopyruvate hydratase
name: Enolase 1
name: Non- neural enolase
name: enolase 1, (alpha)
name: ENO1
xref: UnificationXref1520
feature: FragmentFeature163
cellular location: intracellular
comment: Reactome DB_ID: 4231517
display name: NNE

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P61889
data source: Provenance1
name: malate dehydrogenase 2, NAD (mitochondrial)
name: malate dehydrogenase 2
name: P61889
name: Malate dehydrogenase, mitochondrial precursor
xref: UnificationXref1579
feature: FragmentFeature166
cellular location: intracellular
comment: Reactome DB_ID: 4231611
display name: MDH2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P24182
data source: Provenance1
name: Pyruvic carboxylase
name: Pyruvate carboxylase, mitochondrial precursor
name: P24182
name: pyruvate carboxylase
xref: UnificationXref1560
feature: FragmentFeature165
cellular location: intracellular
comment: Reactome DB_ID: 4231523
display name: PC

http://identifiers.org/pubmed/11248239
type: PublicationXref
id: 11248239
author: Gärtner, J
author: Mayerhofer, P
author: Roerig, P
author: Holzinger, A
db: Pubmed
title: Characterization and functional analysis of the nucleotide binding fold in human peroxisomal ATP binding cassette transporters
source: FEBS Lett 492:66-72
year: 2001

http://identifiers.org/pubmed/12009299
type: PublicationXref
id: 12009299
author: Wang, Z
author: Wang, Y
author: Huang, Y
author: Mao, Y
author: Xu, Y
author: Gu, X
author: Gu, S
author: Xie, Y
author: Li, Y
author: Ji, C
author: Ying, K
author: Deng, Y
db: Pubmed
title: NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties
source: Int J Biochem Cell Biol 34:1035-50
year: 2002

Urea synthesis
type: Pathway
data source: Provenance1
pathway component: ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate
pathway component: argininosuccinate <=> fumarate + arginine
pathway component: carbamoyl phosphate + ornithine => citrulline + orthophosphate
evidence: Evidence533
xref: UnificationXref3518
xref: UnificationXref3517
xref: RelationshipXref521
pathway order: PathwayStep520
pathway order: PathwayStep519
pathway order: PathwayStep518
display name: Urea cycle
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:P0AG16
type: ProteinReference
xref: UnificationXref2640
organism: BioSource1

UniProt:P0AFP4
type: ProteinReference
xref: UnificationXref188
organism: BioSource1

N-(3-Aminopropyl)-1,4-butane-diamine
type: SmallMoleculeReference
name: Spermidine
name: Spermidine [ChEBI:16610]
xref: UnificationXref3538

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0ADG4
data source: Provenance1
name: IMPA1
name: P0ADG4
xref: UnificationXref1761
feature: FragmentFeature186
cellular location: intracellular
comment: Reactome DB_ID: 4233169
display name: IMPA

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A717
data source: Provenance1
name: Ribose-phosphate pyrophosphokinase I
name: PPRibP
name: phosphoribosyl pyrophosphate synthetase 1
name: P0A717
name: PRS-I
name: Phosphoribosyl pyrophosphate synthetase I
name: Ribose-phosphate pyrophosphokinase I (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase I) (PPRibP) (PRS-I)
xref: UnificationXref1744
feature: FragmentFeature185
cellular location: intracellular
comment: Reactome DB_ID: 4231785
display name: PRPS1

P0A6F3
type: Protein
entity reference: P0A6F3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ATP:glycerol 3-phosphotransferase
name: Glycerokinase
name: Glycerol kinase
xref: UnificationXref1802
feature: FragmentFeature190
cellular location: intracellular
comment: Reactome DB_ID: 4231961
display name: GK

P23872
type: Protein
entity reference: P23872
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Hormone Sensitve Lipase
name: LIPE
xref: UnificationXref1791
feature: FragmentFeature189
cellular location: intracellular
comment: Reactome DB_ID: 4232156
display name: HSL

phospho-p-S649,S650-LIPE
type: Protein
entity reference: P23872
data source: Provenance1
xref: UnificationXref1785
feature: ModificationFeature23
feature: ModificationFeature24
feature: FragmentFeature188
cellular location: intracellular
comment: Reactome DB_ID: 4232159

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0ADG4
data source: Provenance1
name: P0ADG4
name: IMP.18P
xref: UnificationXref1764
feature: FragmentFeature187
cellular location: intracellular
comment: Reactome DB_ID: 4233172
display name: IMPA2

LPAAT-alpha
type: Protein
entity reference: UniProt:P26647
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: G15 protein
name: Lysophosphatidic acid acyltransferase-alpha
name: 1-acylglycerol-3-phosphate O- acyltransferase 1
name: 1- AGP acyltransferase 1
name: P26647
name: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
xref: UnificationXref1829
feature: FragmentFeature192
cellular location: intracellular
comment: Reactome DB_ID: 4231950
display name: AGPAT1

LPAAT
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: LPAAT-alpha
xref: UnificationXref1831
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231952
display name: AGPAT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A7A7
data source: Provenance1
name: GPAM(1-828)
name: P0A7A7
name: Glycerol-3-phosphate acyltransferase, mitochondrial
name: GPAT1
xref: UnificationXref1815
feature: FragmentFeature191
cellular location: intracellular
comment: Reactome DB_ID: 4231955
display name: GPAM

GPAM or GPAT2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1816
cellular location: intracellular
comment: Reactome DB_ID: 4231956
comment: Converted from EntitySet in Reactome

http://identifiers.org/pubmed/9251237
type: PublicationXref
id: 9251237
author: Gallagher, JT
author: Stringer, SE
db: Pubmed
title: Heparan sulphate
source: Int J Biochem Cell Biol 29:709-14
year: 1997

http://identifiers.org/pubmed/2667896
type: PublicationXref
id: 2667896
author: Hwang, PK
author: Newgard, CB
author: Fletterick, RJ
db: Pubmed
title: The family of glycogen phosphorylases: structure and function
source: Crit Rev Biochem Mol Biol 24:69-99
year: 1989

UniProt:P0AG07
type: ProteinReference
xref: UnificationXref1701
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A6T3
data source: Provenance1
name: P0A6T3
name: Galactose kinase
name: Galactokinase
xref: UnificationXref1654
feature: FragmentFeature176
cellular location: intracellular
comment: Reactome DB_ID: 4231455
display name: GALK1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P09147
data source: Provenance1
name: UDP- galactose 4-epimerase
name: UDP-galactose 4-epimerase
name: UDP-glucose 4-epimerase
name: P09147
name: UDP-galactose 4-epimerase apoenzyme
name: GALE_HUMAN
name: Galactowaldenase
xref: UnificationXref1667
feature: FragmentFeature178
cellular location: intracellular
comment: Reactome DB_ID: 4231465
display name: GALE

P09148
type: Protein
entity reference: UniProt:P09148
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Galactose-1-phosphate uridylyltransferase
xref: UnificationXref1663
feature: FragmentFeature177
cellular location: intracellular
comment: Reactome DB_ID: 4231460
display name: GALT

Vitamin B5 (pantothenate) metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 110132.9
evidence: Evidence475
xref: UnificationXref3171
xref: UnificationXref3172
xref: RelationshipXref449
pathway order: PathwayStep461
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:P36938
type: ProteinReference
xref: UnificationXref1617
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P00350
data source: Provenance1
name: 6-phosphogluconate dehydrogenase, decarboxylating
name: phosphogluconate dehydrogenase
name: 6-phosphogluconate 2-dehydrogenase
name: P00350
name: PGD(2-483)
xref: UnificationXref1694
feature: FragmentFeature180
cellular location: intracellular
comment: Reactome DB_ID: 4231670
display name: PGD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AC53
data source: Provenance1
name: P0AC53
name: Glucose-6-phosphate 1-dehydrogenase
xref: UnificationXref1679
feature: FragmentFeature179
cellular location: intracellular
comment: Reactome DB_ID: 4231471
display name: G6PD

Homologues of TALDO1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1718
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231691

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0AG07
data source: Provenance1
name: P0AG07
name: Ribulose-phosphate 3-epimerase
name: Ribulose-5-phosphate-3- epimerase
name: HUSSY-17
name: ribulose phosphate 3-epimerase
name: ribulose-5-phosphate epimerase
name: phosphopentose isomerase
xref: UnificationXref1702
feature: FragmentFeature181
cellular location: intracellular
comment: Reactome DB_ID: 4231676
display name: RPE

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0A867
data source: Provenance1
name: transaldolase 1
name: P0A867
xref: UnificationXref1717
feature: FragmentFeature183
cellular location: intracellular
comment: Reactome DB_ID: 4231690
display name: TALDO1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0A870
data source: Provenance1
name: transaldolase 1
name: P0A870
xref: UnificationXref1715
feature: FragmentFeature182
cellular location: intracellular
comment: Reactome DB_ID: 4231687
display name: TALDO1

http://identifiers.org/pubmed/19428801
type: PublicationXref
id: 19428801
author: Buddhala, C
author: Wu, Jer-Yuarn
author: Hsu, CC
db: Pubmed
title: A novel mechanism for GABA synthesis and packaging into synaptic vesicles
source: Neurochem Int 55:9-12
year: 2009

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P0A7Z0
data source: Provenance1
name: RPIA(1-237)
name: ribose 5-phosphate isomerase
name: P0A7Z0
xref: UnificationXref1727
feature: FragmentFeature184
cellular location: intracellular
comment: Reactome DB_ID: 4231682
display name: RPIA

http://identifiers.org/pubmed/11752427
type: PublicationXref
id: 11752427
author: McCarthy, DB
author: Stoops, JK
author: O'Connor, CM
author: Reed, LJ
author: Zhou, ZH
db: Pubmed
title: The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes.
source: Proc Natl Acad Sci U S A 98:14802-7
year: 2001

http://identifiers.org/pubmed/12721307
type: PublicationXref
id: 12721307
author: Lee, PT
author: Tzagoloff, A
author: Hsu, AY
author: Gin, P
author: Clarke, CF
author: Rothman, SC
author: Jonassen, T
db: Pubmed
title: The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis
source: J Biol Chem 278:25308-16
year: 2003

CHEBI:71956
type: SmallMoleculeReference
name: CHEBI:71956 [ChEBI:71956]
xref: UnificationXref1264

UniProt:P0AFJ7
type: ProteinReference
xref: UnificationXref432
organism: BioSource1

UnificationXref1809
type: UnificationXref
id: 76112
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76112

UnificationXref1807
type: UnificationXref
id: REACT_5036
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5036.4

UnificationXref1808
type: UnificationXref
id: CHEBI:16975
db: ChEBI

UnificationXref1801
type: UnificationXref
id: P0A6F3
db: UniProt

UnificationXref1802
type: UnificationXref
id: 4231961
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231961

UnificationXref1800
type: UnificationXref
id: REACT_4327
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4327.2

UnificationXref1805
type: UnificationXref
id: CHEBI:37554
db: ChEBI

UnificationXref1806
type: UnificationXref
id: 75967
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=75967

UnificationXref1803
type: UnificationXref
id: 4231963
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231963

UnificationXref1804
type: UnificationXref
id: REACT_148865
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148865.4

UniProt:P0AFI0
type: ProteinReference
xref: UnificationXref2067
organism: BioSource1

http://identifiers.org/pubmed/17604717
type: PublicationXref
id: 17604717
author: Manning, BD
author: Cantley, LC
db: Pubmed
title: AKT/PKB signaling: navigating downstream
source: Cell 129:1261-74
year: 2007

UniProt:P0AFI7
type: ProteinReference
xref: UnificationXref3202
organism: BioSource1

UnificationXref1818
type: UnificationXref
id: REACT_112568
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112568.8

UnificationXref1819
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

UnificationXref1810
type: UnificationXref
id: REACT_4701
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4701.3

UnificationXref1811
type: UnificationXref
id: CHEBI:15346
db: ChEBI

UnificationXref1812
type: UnificationXref
id: 76194
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76194

UnificationXref1813
type: UnificationXref
id: REACT_2732
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2732.2

UnificationXref1814
type: UnificationXref
id: P0A7A7
db: UniProt

UnificationXref1815
type: UnificationXref
id: 4231955
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231955

UnificationXref1816
type: UnificationXref
id: 4231956
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231956

UnificationXref1817
type: UnificationXref
id: 4231958
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231958

UnificationXref1820
type: UnificationXref
id: 1500604
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500604

http://identifiers.org/pubmed/8621489
type: PublicationXref
id: 8621489
author: Jenkins, NA
author: Agre, P
author: Bhakta, KY
author: Copeland, NG
author: Griffin, CA
author: Yonescu, R
author: Gilbert, DJ
author: Preston, GM
author: Lee, MD
author: Raina, S
db: Pubmed
title: The human Aquaporin-5 gene. Molecular characterization and chromosomal localization
source: J Biol Chem 271:8599-604
year: 1996

UnificationXref1829
type: UnificationXref
id: 4231950
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231950

UnificationXref1827
type: UnificationXref
id: REACT_120138
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_120138.1

UnificationXref1828
type: UnificationXref
id: P26647
db: UniProt

UnificationXref1825
type: UnificationXref
id: CHEBI:16337
db: ChEBI

http://identifiers.org/pubmed/21755941
type: PublicationXref
id: 21755941
author: Sofia, MJ
author: Murakami, E
author: Bao, H
author: Furman, PA
author: Du, J
author: Mosley, RT
db: Pubmed
title: Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates
source: J Med Chem 54:5902-14
year: 2011

UnificationXref1826
type: UnificationXref
id: 426755
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426755

UnificationXref1823
type: UnificationXref
id: 1500578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500578

UnificationXref1824
type: UnificationXref
id: REACT_118995
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118995.1

UnificationXref1821
type: UnificationXref
id: REACT_119202
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119202.1

UnificationXref1822
type: UnificationXref
id: CHEBI:17984
db: ChEBI

UnificationXref1831
type: UnificationXref
id: 4231952
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231952

UnificationXref1830
type: UnificationXref
id: 4231951
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231951

http://identifiers.org/pubmed/9124315
type: PublicationXref
id: 9124315
author: Huang, MY
author: Young, JD
author: Yao, SY
author: Ritzel, MW
author: Elliott, JF
author: Cass, CE
db: Pubmed
title: Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)
source: Am J Physiol Cell Physiol 272:707-714
year: 1997

UnificationXref1836
type: UnificationXref
id: CHEBI:28935
db: ChEBI

UnificationXref1837
type: UnificationXref
id: 77284
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77284

UnificationXref1838
type: UnificationXref
id: REACT_4177
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4177.1

UnificationXref1839
type: UnificationXref
id: CHEBI:27402
db: ChEBI

UnificationXref1832
type: UnificationXref
id: 4231954
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231954

UnificationXref1833
type: UnificationXref
id: REACT_155231
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155231.3

UnificationXref1834
type: UnificationXref
id: 4233358
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4233358

UnificationXref1835
type: UnificationXref
id: REACT_109270
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_109270.9

Catalysis69
type: Catalysis
data source: Provenance1
controlled: serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate
control type: ACTIVATION
xref: RelationshipXref110
xref: RelationshipXref111
controller: SARS2 dimer (name copied from entity in Homo sapiens)

Catalysis68
type: Catalysis
data source: Provenance1
controlled: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate
control type: ACTIVATION
xref: RelationshipXref109
xref: RelationshipXref108
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis67
type: Catalysis
data source: Provenance1
controlled: phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate
control type: ACTIVATION
xref: RelationshipXref106
xref: RelationshipXref107
controller: P08312

http://identifiers.org/pubmed/10684970
type: PublicationXref
id: 10684970
author: Cai, YC
author: Bullard, JM
author: Spremulli, LL
db: Pubmed
title: Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
source: Biochim Biophys Acta 1490:245-58
year: 2000

plasma membrane
type: CellularLocationVocabulary
xref: UnificationXref37

GMP, IMP
type: SmallMolecule
data source: Provenance1
member physical entity: SmallMolecule448
member physical entity: SmallMolecule449
xref: UnificationXref2825
xref: UnificationXref2824
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500260

2-oxoglutarate
type: SmallMolecule
entity reference: CHEBI:30915
data source: Provenance1
name: alpha-ketoglutarate
name: Oxoglutaric acid
name: 2-Oxoglutarate
name: alpha-Ketoglutaric acid
name: 2-Ketoglutaric acid
xref: UnificationXref1593
xref: UnificationXref1592
cellular location: GO:0005829
comment: Reactome DB_ID: 29406
display name: 2OG

http://identifiers.org/pubmed/15157936
type: PublicationXref
id: 15157936
author: Bertinato, J
author: L'Abbé, MR
db: Pubmed
title: Maintaining copper homeostasis: regulation of copper-trafficking proteins in response to copper deficiency or overload
source: J Nutr Biochem 15:316-22
year: 2004

L-Apple acid
type: SmallMolecule
entity reference: CHEBI:30797
data source: Provenance1
name: (S)-Malate
name: L-Malate
name: L-2-Hydroxybutanedioic acid
name: L-Malic acid
xref: UnificationXref1577
xref: UnificationXref1576
cellular location: GO:0005759
comment: Reactome DB_ID: 113544
display name: MAL

Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence557
EC number: 4.1.1.37
xref: UnificationXref3675
xref: UnificationXref3674
participant stoichiometry: Stoichiometry357
left: Uroporphyrinogen I
display name: UROD decarboxylates URO1 to COPRO1
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Carbon dioxide
right: Coproporphyrinogen I

AMP, dAMP, GMP, IMP
type: SmallMolecule
data source: Provenance1
member physical entity: Guanosine monophosphate
member physical entity: adenylic acid
member physical entity: deoxyadenylic acid
member physical entity: inosinic acid
xref: UnificationXref2851
xref: UnificationXref2852
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500101

Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence556
EC number: 4.1.1.37
xref: UnificationXref3667
xref: UnificationXref3666
participant stoichiometry: Stoichiometry355
left: Uroporphyrinogen III
display name: UROD decarboxylates URO3 to COPRO3
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Carbon dioxide
right: Coproporphyrinogen III

NH4+
type: SmallMolecule
entity reference: CHEBI:28938
data source: Provenance1
xref: UnificationXref2831
xref: UnificationXref2832
cellular location: GO:0005829
comment: Reactome DB_ID: 31633

Oxalacetic acid
type: SmallMolecule
entity reference: CHEBI:30744
data source: Provenance1
name: Oxosuccinic acid
name: 2-oxobutanedioic acid
name: Oxaloacetic acid
name: Oxaloacetate
xref: UnificationXref1595
xref: UnificationXref1594
cellular location: GO:0005829
comment: Reactome DB_ID: 76213
display name: OA

Four PBGs combine through deamination to form hydroxymethylbilane (HMB)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence555
EC number: 2.5.1.61
xref: UnificationXref3656
xref: UnificationXref3655
participant stoichiometry: Stoichiometry351
participant stoichiometry: Stoichiometry352
left: Water
left: Porphobilinogen
display name: 4 PBGs bind to form HMB
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule468
right: Hydroxymethylbilane

Mn(III)
type: SmallMolecule
entity reference: CHEBI:18291
data source: Provenance1
name: Mn(II)
name: Manganese
xref: UnificationXref1565
xref: UnificationXref1566
cellular location: GO:0005759
comment: Reactome DB_ID: 113527
display name: Mn2+

Two molecules of ALA condense to form porphobilinogen (PBG)
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence554
EC number: 4.2.1.24
xref: UnificationXref3645
xref: UnificationXref3644
participant stoichiometry: Stoichiometry349
participant stoichiometry: Stoichiometry350
left: delta-Aminolevulinic acid
display name: ALAD condenses 2 dALAs to form PBG
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: Porphobilinogen

Coenzyme R
type: SmallMolecule
entity reference: CHEBI:15956
data source: Provenance1
name: D-Biotin
name: Biotin
name: Vitamin H
xref: UnificationXref1563
xref: UnificationXref1562
cellular location: GO:0005759
comment: Reactome DB_ID: 29582
display name: Btn

ALAD octamer associates with Pb++, forming a catalytically inactive complex
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence553
xref: UnificationXref3636
xref: UnificationXref3637
participant stoichiometry: Stoichiometry342
participant stoichiometry: Stoichiometry345
left: Complex196
left: Pb++
display name: ALAD binds to Pb2+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Zn(II)
right: Complex197

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Provenance1
xref: UnificationXref1573
xref: UnificationXref1574
cellular location: GO:0005759
comment: Reactome DB_ID: 113529

Excess cysteine yields lanthionine and H2S
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence549
EC number: 4.4.1.1
xref: UnificationXref3621
xref: UnificationXref3620
participant stoichiometry: Stoichiometry341
left: L-2-amino-3-mercaptopropionic acid
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H2S
right: L-Lanthionine

Acetyl coenzyme A
type: SmallMolecule
entity reference: CHEBI:15351
data source: Provenance1
name: Acetyl-CoA
xref: UnificationXref1571
xref: UnificationXref1572
cellular location: GO:0005759
comment: Reactome DB_ID: 113559
display name: Ac-CoA

Excess homocysteine yields homolanthionine and H2S
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence548
EC number: 4.4
xref: UnificationXref3615
xref: UnificationXref3614
participant stoichiometry: Stoichiometry340
left: Homocysteine
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H2S
right: L-Homolanthionine

zinc
type: SmallMolecule
entity reference: CHEBI:29105
data source: Provenance1
name: Zn(II)
name: Zn++
xref: UnificationXref2856
xref: UnificationXref2855
cellular location: plasma membrane
comment: Reactome DB_ID: 109265
display name: Zn2+

Catalysis65
type: Catalysis
data source: Provenance1
controlled: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate
control type: ACTIVATION
xref: RelationshipXref103
xref: RelationshipXref102
controller: Note: the coordinates are copied over from Homo sapiens.

Oxalacetic acid
type: SmallMolecule
entity reference: CHEBI:30744
data source: Provenance1
name: Oxosuccinic acid
name: 2-oxobutanedioic acid
name: Oxaloacetic acid
name: Oxaloacetate
xref: UnificationXref1554
xref: UnificationXref1553
cellular location: GO:0005759
comment: Reactome DB_ID: 113587
display name: OA

Cysteine is degraded to serine and H2S
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence547
EC number: 4.4.1.1
xref: UnificationXref3610
xref: UnificationXref3609
left: Water
left: L-2-amino-3-mercaptopropionic acid
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H2S
right: L-serine

adenosine, deoxyadenosine, guanosine, inosine
type: SmallMolecule
data source: Provenance1
member physical entity: Adenosine
member physical entity: 2'-deoxyadenosine
member physical entity: SmallMolecule105
member physical entity: SmallMolecule104
xref: UnificationXref2854
xref: UnificationXref2853
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500104

Catalysis66
type: Catalysis
data source: Provenance1
controlled: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate
control type: ACTIVATION
xref: RelationshipXref105
xref: RelationshipXref104
controller: P07813

Homocysteine is degraded to oxobutanoate and H2S
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence546
EC number: 4.4.1.2
xref: UnificationXref3607
xref: UnificationXref3608
left: Water
left: Homocysteine
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: H2S
right: 2-Ketobutyrate
right: SmallMolecule468

Catalysis63
type: Catalysis
data source: Provenance1
controlled: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
control type: ACTIVATION
xref: RelationshipXref98
xref: RelationshipXref99
controller: Note: the coordinates are copied over from Homo sapiens.

Phosphate
type: SmallMolecule
entity reference: CHEBI:18367
data source: Provenance1
name: Orthophosphate
xref: UnificationXref1557
xref: UnificationXref1558
cellular location: GO:0005759
comment: Reactome DB_ID: 113548
display name: Pi

Cleavage of cystathionine into cysteine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence544
EC number: 4.4.1.1
xref: UnificationXref3598
xref: UnificationXref3597
left: Water
left: L-Cystathionine
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: 2-Ketobutyrate
right: SmallMolecule468
right: L-2-amino-3-mercaptopropionic acid

Xanthine
type: SmallMolecule
entity reference: Xanthine [ChEBI:17712]
data source: Provenance1
xref: UnificationXref2868
xref: UnificationXref2867
cellular location: GO:0005829
comment: Reactome DB_ID: 30064
display name: XAN

Catalysis64
type: Catalysis
data source: Provenance1
controlled: glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
control type: ACTIVATION
xref: RelationshipXref101
xref: RelationshipXref100
controller: Note: the coordinates are copied over from Homo sapiens.

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: ADP [ChEBI:16761]
data source: Provenance1
xref: UnificationXref1556
xref: UnificationXref1555
cellular location: GO:0005759
comment: Reactome DB_ID: 113581
display name: ADP

deoxyadenylic acid
type: SmallMolecule
entity reference: 2'-deoxyadenosine 5'-monophosphate [ChEBI:17713]
data source: Provenance1
name: 2'-deoxyadenosine 5'-monophosphate
xref: UnificationXref2846
xref: UnificationXref2845
cellular location: extracellular region
comment: Reactome DB_ID: 109295
display name: dAMP

Catalysis61
type: Catalysis
data source: Provenance1
controlled: asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate
control type: ACTIVATION
xref: RelationshipXref95
xref: RelationshipXref94
controller: Note: the coordinates are copied over from Homo sapiens.

adenylic acid
type: SmallMolecule
entity reference: CHEBI:16027
data source: Provenance1
name: adenosine 5'-monophosphate
xref: UnificationXref2843
xref: UnificationXref2844
cellular location: extracellular region
comment: Reactome DB_ID: 109275
display name: AMP

Catalysis62
type: Catalysis
data source: Provenance1
controlled: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate
control type: ACTIVATION
xref: RelationshipXref96
xref: RelationshipXref97
controller: DARS2 dimer (name copied from entity in Homo sapiens)

inosinic acid
type: SmallMolecule
entity reference: CHEBI:17202
data source: Provenance1
name: inosine 5'-monophosphate
xref: UnificationXref2849
xref: UnificationXref2850
cellular location: extracellular region
comment: Reactome DB_ID: 109286
display name: IMP

Guanosine monophosphate
type: SmallMolecule
entity reference: CHEBI:17345
data source: Provenance1
name: Guanosine 5'-phosphate
name: Guanylic acid
name: Guanosine 5'-monophosphate
xref: UnificationXref2847
xref: UnificationXref2848
cellular location: extracellular region
comment: Reactome DB_ID: 113579
display name: GMP

Catalysis60
type: Catalysis
data source: Provenance1
controlled: tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate
control type: ACTIVATION
xref: RelationshipXref91
xref: RelationshipXref92
controller: YARS dimer (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/20147624
type: PublicationXref
id: 20147624
author: Pellegrini-Calace, M
author: Oliva, R
author: Calamita, G
author: Thornton, JM
db: Pubmed
title: Electrostatics of aquaporin and aquaglyceroporin channels correlates with their transport selectivity
source: Proc Natl Acad Sci U S A 107:4135-40
year: 2010

Sodium/Proton exchangers
type: Pathway
data source: Provenance1
pathway component: Na+/H+ exchanger transport (at trans-golgi membrane)
pathway component: Na+/H+ exchanger transport (at late endosome membrane)
pathway component: Na+/H+ exchanger transport (at cell membrane)
pathway component: Na+/H+ exchanger transport (at early endosome membrane)
evidence: Evidence60
xref: UnificationXref417
xref: UnificationXref418
pathway order: PathwayStep53
pathway order: PathwayStep50
pathway order: PathwayStep52
pathway order: PathwayStep51
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Uroporphyrinogen I
type: SmallMoleculeReference
name: Uroporphyrinogen I [ChEBI:9904]
xref: UnificationXref3668

Catalysis79
type: Catalysis
data source: Provenance1
controlled: Beta-glucuronidase (GUSB) hydrolyses glucuronate from HA tetrasaccharides
control type: ACTIVATION
xref: RelationshipXref147
xref: RelationshipXref146
controller: GUSB tetramer (name copied from entity in Homo sapiens)

Catalysis78
type: Catalysis
data source: Provenance1
controlled: glutamate uptake by astrocytes
control type: ACTIVATION
xref: RelationshipXref140
xref: RelationshipXref9
controller: PhysicalEntity20

http://identifiers.org/pubmed/9487141
type: PublicationXref
id: 9487141
author: Wilton, DC
author: Buckland, AG
author: Kinkaid, AR
db: Pubmed
title: Cardiolipin hydrolysis by human phospholipases A2. The multiple enzymatic activities of human cytosolic phospholipase A2
source: Biochim Biophys Acta 1390:65-72
year: 1998

Degradation of GABA
type: Pathway
data source: Provenance1
pathway component: Conversion of GABA to Succinate Semialdehyde
pathway component: Conversion of succinate semialdehyde to succinate
evidence: Evidence176
xref: UnificationXref1211
xref: UnificationXref1210
pathway order: PathwayStep164
pathway order: PathwayStep165
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/19675644
type: PublicationXref
id: 19675644
author: Ribbe, MW
author: Mendel, RR
author: Schwarz, G
db: Pubmed
title: Molybdenum cofactors, enzymes and pathways
source: Nature 460:839-47
year: 2009

Metabolism of proteins
type: Pathway
data source: Provenance1
pathway component: Post-translational protein modification
pathway component: REACT 135093.5
pathway component: REACT 78715.9
evidence: Evidence167
xref: UnificationXref1142
xref: RelationshipXref127
xref: UnificationXref1141
pathway order: PathwayStep148
pathway order: PathwayStep137
pathway order: PathwayStep158
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

2-Amino-3-methylbutyric acid
type: SmallMoleculeReference
name: L-Valine
name: L-Valine [ChEBI:16414]
xref: UnificationXref3834

PM
type: SmallMoleculeReference
name: Pyridoxamine [ChEBI:8669]
name: Pyridoxamine
xref: UnificationXref3184

glycolate + O2 => glyoxylate + H2O2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence541
xref: UnificationXref3580
xref: UnificationXref3579
left: Oxygen
left: Glycolate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Glyoxylate
right: Hydrogen peroxide

NADPH
type: SmallMolecule
entity reference: CHEBI:16474
data source: Provenance1
xref: UnificationXref2883
xref: UnificationXref2884
cellular location: GO:0005782
comment: Reactome DB_ID: 113602
display name: TPNH

UnificationXref90
type: UnificationXref
id: 428040
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428040

glyoxylate + NADPH + H+ => glycolate + NADP+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence540
EC number: 1.1.1.79
xref: UnificationXref3571
xref: UnificationXref3572
left: H+
left: Glyoxylate
left: NADPH
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADP+
right: Glycolate

Oxygen
type: SmallMolecule
entity reference: CHEBI:15379
data source: Provenance1
xref: UnificationXref2881
xref: UnificationXref2882
cellular location: GO:0005782
comment: Reactome DB_ID: 113535
display name: O2

Hydrogen peroxide
type: SmallMolecule
entity reference: CHEBI:16240
data source: Provenance1
xref: UnificationXref2879
xref: UnificationXref2880
cellular location: GO:0005782
comment: Reactome DB_ID: 113575
display name: H2O2

UnificationXref92
type: UnificationXref
id: CHEBI:21622
db: ChEBI

D-Xylulose 5-phosphate
type: SmallMolecule
entity reference: CHEBI:16332
data source: Provenance1
xref: UnificationXref1700
xref: UnificationXref1699
cellular location: GO:0005829
comment: Reactome DB_ID: 29790
display name: XY5P

UniProt:P21889
type: ProteinReference
xref: UnificationXref857
organism: BioSource1

Conversion of glyoxylate to oxalate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence542
EC number: 1.2.3.5
xref: UnificationXref3585
xref: UnificationXref3584
left: Glyoxylate
left: Oxygen
left: SmallMolecule340
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Oxalate
right: Hydrogen peroxide

Hydrogen peroxide
type: SmallMolecule
entity reference: CHEBI:16240
data source: Provenance1
xref: UnificationXref2876
xref: UnificationXref2875
cellular location: GO:0005829
comment: Reactome DB_ID: 29408
display name: H2O2

UnificationXref91
type: UnificationXref
id: REACT_19520
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19520.1

D-Ribulose 5-phosphate
type: SmallMolecule
entity reference: CHEBI:17363
data source: Provenance1
xref: UnificationXref1691
xref: UnificationXref1692
cellular location: GO:0005829
comment: Reactome DB_ID: 29732
display name: RU5P

gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence534
xref: UnificationXref3528
xref: UnificationXref3529
left: DPN
left: Water
left: 4-Trimethylammoniobutanal
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule385
right: proton
right: 4-Trimethylammoniobutanoate

UnificationXref94
type: UnificationXref
id: REACT_20388
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20388.2

Carbon dioxide
type: SmallMolecule
entity reference: CO2 [ChEBI:16526]
data source: Provenance1
xref: UnificationXref1688
xref: UnificationXref1689
cellular location: GO:0005829
comment: Reactome DB_ID: 113528
display name: CO2

argininosuccinate <=> fumarate + arginine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence532
EC number: 4.3.2.1
xref: UnificationXref3516
xref: UnificationXref3515
left: N(omega)-(L-Arginino)succinate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Fumarate
right: (S)-2-Amino-5-guanidinovaleric acid

UnificationXref93
type: UnificationXref
id: 428639
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428639

6-Phospho-D-gluconate
type: SmallMolecule
entity reference: 6-Phospho-D-gluconate [ChEBI:16863]
data source: Provenance1
xref: UnificationXref1687
xref: UnificationXref1686
cellular location: GO:0005829
comment: Reactome DB_ID: 29996
display name: PDG

Transamination of MOB to methionine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence537
EC number: 2.6.1
xref: UnificationXref3554
xref: RelationshipXref529
xref: UnificationXref3553
left: 4-Methylthio-2-oxobutanoate (1-)
left: PhysicalEntity31
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Methionine
right: PhysicalEntity32

UnificationXref96
type: UnificationXref
id: REACT_20184
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20184.2

D-Glucono-1,5-lactone 6-phosphate
type: SmallMolecule
entity reference: 6-Phospho-D-glucono-1,5-lactone
data source: Provenance1
xref: UnificationXref1677
xref: UnificationXref1676
cellular location: GO:0005829
comment: Reactome DB_ID: 31467
display name: 6-Phospho-D-glucono-1,5-lactone

Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence536
EC number: 2.5.1.16
xref: UnificationXref3547
xref: UnificationXref3546
left: 1,4-Butanediamine
left: Decarboxylated AdoMet
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: S-methylthio adenosine
right: Spermidine

UnificationXref95
type: UnificationXref
id: 428633
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428633

DPN
type: SmallMolecule
entity reference: NAD
data source: Provenance1
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref1668
xref: UnificationXref1669
cellular location: GO:0005829
comment: Reactome DB_ID: 29360
display name: NAD

kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence528
EC number: 2.6.1.7
xref: UnificationXref3476
xref: UnificationXref3475
left: SmallMolecule208
left: 3-Anthraniloyl-L-alanine
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule150
right: 4-(2-aminophenyl)-2,4-dioxobutanoic acid

UnificationXref98
type: UnificationXref
id: 4232574
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232574

Catalysis74
type: Catalysis
data source: Provenance1
controlled: glutamine + H2O => glutamate + NH4+ [GLS]
control type: ACTIVATION
xref: RelationshipXref132
xref: RelationshipXref131
controller: GLS dimers

UDP-D-galactopyranose
type: SmallMolecule
entity reference: CHEBI:18307
data source: Provenance1
name: UDPgalactose
name: UDP-D-galactose
xref: UnificationXref1660
xref: UnificationXref1661
cellular location: GO:0005829
comment: Reactome DB_ID: 29452
display name: UDP-Gal

UnificationXref97
type: UnificationXref
id: 4232573
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232573

Catalysis75
type: Catalysis
data source: Provenance1
controlled: L-Glutamate uptake by neurons
control type: ACTIVATION
xref: RelationshipXref133
xref: RelationshipXref9
controller: PhysicalEntity19

UDPglucose
type: SmallMolecule
entity reference: UDPglucose
data source: Provenance1
name: UDP-D-glucose
name: UDP-glucose
xref: UnificationXref1658
xref: UnificationXref1659
cellular location: GO:0005829
comment: Reactome DB_ID: 29410
display name: UDP-Glc

ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence531
EC number: 6.3.4.5
xref: UnificationXref3504
xref: UnificationXref3505
left: 2-Amino-5-ureidovaleric acid
left: SmallMolecule9
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule139
right: SmallMolecule137
right: N(omega)-(L-Arginino)succinate

flavin mononucleotide
type: SmallMolecule
entity reference: FMN [ChEBI:17621]
data source: Provenance1
name: riboflavin-5-phosphate
xref: UnificationXref2914
xref: UnificationXref2913
cellular location: GO:0005743
comment: Reactome DB_ID: 76629
display name: FMN

Catalysis76
type: Catalysis
data source: Provenance1
controlled: Conversion of GABA to Succinate Semialdehyde
control type: ACTIVATION
xref: RelationshipXref135
xref: RelationshipXref136
controller: Homodimer of 4 aminobutyrate aminotransferase (name copied from entity in Homo sapiens)

alpha-D-Galactopyranose 1-phosphate
type: SmallMolecule
entity reference: alpha-D-Galactose 1-phosphate [ChEBI:17973]
data source: Provenance1
xref: UnificationXref1651
xref: UnificationXref1652
cellular location: GO:0005829
comment: Reactome DB_ID: 30170
display name: alpha-D-Galactose 1-phosphate

carbamoyl phosphate + ornithine => citrulline + orthophosphate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence530
EC number: 2.1.3.3
xref: UnificationXref3494
xref: UnificationXref3495
left: Carbamoyl phosphate
left: (S)-2,5-Diaminopentanoate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: 2-Amino-5-ureidovaleric acid
right: Phosphate

uracil-6-carboxylic acid
type: SmallMolecule
entity reference: Uracil-6-carboxylic acid
data source: Provenance1
name: orotic acid
xref: UnificationXref2909
xref: UnificationXref2908
cellular location: GO:0005829
comment: Reactome DB_ID: 76632
display name: orotate

UnificationXref99
type: UnificationXref
id: 4232575
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232575

Catalysis77
type: Catalysis
data source: Provenance1
controlled: Conversion of succinate semialdehyde to succinate
control type: ACTIVATION
xref: RelationshipXref137
xref: RelationshipXref138
controller: Succinate-semialdehyde dehydrogenase, mitochondrial

Cori ester
type: SmallMolecule
entity reference: CHEBI:16077
data source: Provenance1
name: alpha-D-Glucose 1-phosphate
name: D-Glucose alpha-1-phosphate
name: D-Glucose 1-phosphate
xref: UnificationXref1616
xref: UnificationXref1615
cellular location: GO:0005829
comment: Reactome DB_ID: 29548
display name: Glc1P

Coenzyme QH2
type: SmallMolecule
entity reference: Coenzyme QH2
data source: Provenance1
name: CoQH2
name: ubiquinol
xref: UnificationXref2905
xref: UnificationXref2906
cellular location: GO:0005743
comment: Reactome DB_ID: 76633
display name: QH2

Catalysis70
type: Catalysis
data source: Provenance1
controlled: tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate
control type: ACTIVATION
xref: RelationshipXref112
xref: RelationshipXref113
controller: P00954

(S)-4,5-dihydroorotate
type: SmallMolecule
entity reference: CHEBI:17025
data source: Provenance1
name: L-dihydroorotic acid
name: dihydro-L-orotic acid
name: (S)-dihydroorotate
xref: UnificationXref2903
xref: UnificationXref2902
cellular location: GO:0005829
comment: Reactome DB_ID: 76630
display name: L-dihydroorotate

Catalysis71
type: Catalysis
data source: Provenance1
controlled: tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate
control type: ACTIVATION
xref: RelationshipXref91
xref: RelationshipXref114
controller: YARS2 dimer (name copied from entity in Homo sapiens)

Coenzyme Q
type: SmallMolecule
entity reference: CHEBI:16389
data source: Provenance1
name: CoQ
name: ubiquinone
xref: UnificationXref2899
xref: UnificationXref2900
cellular location: GO:0005743
comment: Reactome DB_ID: 73663
display name: Q

Catalysis72
type: Catalysis
data source: Provenance1
controlled: Fructose 6-phosphate isomerizes to Mannose 6-phosphate
control type: ACTIVATION
xref: RelationshipXref119
xref: RelationshipXref118
controller: Note: the coordinates are copied over from Homo sapiens.

http://identifiers.org/pubmed/10212249
type: PublicationXref
id: 10212249
author: Sondermann, P
author: Steegborn, C
author: Wahl, MC
author: Huber, R
author: Marinkovic, S
author: Jacob, U
author: Worbs, M
author: Clausen, T
db: Pubmed
title: Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration
source: J Biol Chem 274:12675-84
year: 1999

protoheme
type: SmallMolecule
entity reference: Protoheme
data source: Provenance1
xref: UnificationXref2887
xref: UnificationXref2886
cellular location: GO:0005782
comment: Reactome DB_ID: 113569
display name: heme

Catalysis73
type: Catalysis
data source: Provenance1
controlled: Estrone is hydrogenated to estradiol
control type: ACTIVATION
xref: RelationshipXref128
xref: RelationshipXref129
controller: HSD17B1 dimer (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/6451249
type: PublicationXref
id: 6451249
author: Vora, S
db: Pubmed
title: Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system
source: Blood 57:724-32
year: 1981

Catalysis48
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Urea into Cells by Aquaporins
control type: ACTIVATION
xref: RelationshipXref71
xref: RelationshipXref70
controller: Aquaporin-9, Aquaporin-10

Catalysis47
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Glycerol out of Cells by Aquaporins
control type: ACTIVATION
xref: RelationshipXref68
xref: RelationshipXref69
controller: AQP3, AQP7, AQP9, AQP10

Stoichiometry9
type: Stoichiometry
physical entity: Protein53
stoichiometric coefficient: 1.0

Catalysis46
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Glycerol into Cells by Aquaporins
control type: ACTIVATION
xref: RelationshipXref68
xref: RelationshipXref69
controller: AQP3, AQP7, AQP9, AQP10

Stoichiometry8
type: Stoichiometry
physical entity: Double-strand DNA containing an ethenocytosine
stoichiometric coefficient: 1.0

Catalysis45
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Anions out of Vesicles by Aquaporin-6
control type: ACTIVATION
xref: RelationshipXref66
xref: RelationshipXref67
controller: AQP6 tetramer (name copied from entity in Homo sapiens)

Stoichiometry7
type: Stoichiometry
physical entity: Protein53
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/10702312
type: PublicationXref
id: 10702312
author: Vaz, FM
author: Ofman, R
author: Fouchier, SW
author: Sommer, M
db: Pubmed
title: Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis.
source: J Biol Chem 275:7390-4
year: 2000

Catalysis49
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Urea out of Cells by Aquaporins
control type: ACTIVATION
xref: RelationshipXref71
xref: RelationshipXref70
controller: Aquaporin-9, Aquaporin-10

http://identifiers.org/pubmed/14977861
type: PublicationXref
id: 14977861
author: Chowdhury, JR
author: Wells, PG
author: Kim, PM
author: Hansen, AJ
author: Ishii, Y
author: Gregory, PA
author: Mackenzie, PI
author: Chowdhury, NR
author: Ritter, JK
author: Kessler, FK
author: Guillemette, C
db: Pubmed
title: Glucuronidation and the UDP-glucuronosyltransferases in health and disease
source: Drug Metab Dispos 32:281-90
year: 2004

C4S/C6S chains
type: SmallMolecule
data source: Provenance1
member physical entity: Chondroitin 4-sulfate chain
member physical entity: Chondroitin 6-sulfate chain
xref: UnificationXref1394
xref: UnificationXref1393
cellular location: lysosomal lumen
comment: Reactome DB_ID: 2065251
comment: Converted from EntitySet in Reactome

Chondroitin 4-sulfate chain
type: SmallMolecule
entity reference: CHEBI:63513
data source: Provenance1
xref: UnificationXref1388
xref: UnificationXref1389
cellular location: lysosomal lumen
comment: Reactome DB_ID: 2065210
display name: C4S chain

UnificationXref85
type: UnificationXref
id: 4232569
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232569

alpha,alpha-trehalose
type: SmallMolecule
entity reference: alpha,alpha-Trehalose
data source: Provenance1
xref: UnificationXref1436
xref: UnificationXref1435
cellular location: extracellular region
comment: Reactome DB_ID: 189078

UnificationXref84
type: UnificationXref
id: 4232568
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232568

Chondroitin chain
type: SmallMolecule
entity reference: CHEBI:63511
data source: Provenance1
xref: UnificationXref1397
xref: UnificationXref1396
cellular location: lysosomal lumen
comment: Reactome DB_ID: 2065239

UnificationXref83
type: UnificationXref
id: 4232567
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232567

D-Fructose 1,6-bisphosphate
type: SmallMolecule
entity reference: D-Fructose 1,6-bisphosphate
data source: Provenance1
xref: UnificationXref1457
xref: UnificationXref1456
cellular location: GO:0005829
comment: Reactome DB_ID: 30014

UnificationXref82
type: UnificationXref
id: 4232566
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232566

alpha-D-Glucose 6-phosphate
type: SmallMolecule
entity reference: alpha-D-Glucose 6-phosphate
data source: Provenance1
xref: UnificationXref1448
xref: UnificationXref1449
cellular location: GO:0005829
comment: Reactome DB_ID: 30537
display name: G6P

UnificationXref81
type: UnificationXref
id: 4232565
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232565

Citrate
type: SmallMolecule
entity reference: CHEBI:30769
data source: Provenance1
xref: UnificationXref1476
xref: UnificationXref1477
cellular location: GO:0005829
comment: Reactome DB_ID: 76190
display name: CIT

UnificationXref80
type: UnificationXref
id: 4232564
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232564

D-Fructose 2,6-bisphosphate
type: SmallMolecule
entity reference: D-Fructose 2,6-bisphosphate [ChEBI:28602]
data source: Provenance1
xref: UnificationXref1472
xref: UnificationXref1473
cellular location: GO:0005829
comment: Reactome DB_ID: 30533

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
entity reference: CHEBI:29052
data source: Provenance1
name: (2R)-2-Hydroxy-3-(phosphonooxy)-propanal
xref: UnificationXref1484
xref: UnificationXref1485
cellular location: GO:0005829
comment: Reactome DB_ID: 29578
display name: GA3P

Dihydroxyacetone phosphate
type: SmallMolecule
entity reference: CHEBI:16108
data source: Provenance1
name: Glycerone phosphate
xref: UnificationXref1482
xref: UnificationXref1481
cellular location: GO:0005829
comment: Reactome DB_ID: 75970
display name: DHAP

Passive Transport of Carbon Dioxide out of the Cell by AQP1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence583
xref: UnificationXref3867
xref: UnificationXref3866
left: Carbon dioxide
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Carbon dioxide

Stoichiometry1
type: Stoichiometry
physical entity: SmallMolecule2
stoichiometric coefficient: 3.0

http://identifiers.org/pubmed/21768372
type: PublicationXref
id: 21768372
author: Murtaugh, L Charles
author: Barrow, Jeffery R
author: Cash, Gabriela M
author: Smith, Aaron P
author: Barrott, Jared J
db: Pubmed
title: Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome
source: Proc. Natl. Acad. Sci. U.S.A. 108:12752-7
year: 2011

Passive Transport of Carbon Dioxide into the Cell by AQP1
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence581
xref: UnificationXref3863
xref: UnificationXref3862
left: Carbon dioxide
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Carbon dioxide

Catalysis40
type: Catalysis
data source: Provenance1
controlled: Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
control type: ACTIVATION
xref: RelationshipXref62
xref: RelationshipXref60
controller: Homologues of SLC28A3

Stoichiometry2
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Catalysis43
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Water out of Cells by Aquaporins
control type: ACTIVATION
xref: RelationshipXref64
xref: RelationshipXref65
controller: Aquaporins that transport water across the plasma membrane.

UnificationXref89
type: UnificationXref
id: GO:0043202
db: GENE ONTOLOGY

Stoichiometry5
type: Stoichiometry
physical entity: DNA containing an apurinic/apyrimidinic (AP) site
stoichiometric coefficient: 1.0

Catalysis44
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Anions into Vesicles by Aquaporin-6
control type: ACTIVATION
xref: RelationshipXref66
xref: RelationshipXref67
controller: AQP6 tetramer (name copied from entity in Homo sapiens)

UnificationXref88
type: UnificationXref
id: REACT_113198
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113198.8

Stoichiometry6
type: Stoichiometry
physical entity: Protein52
stoichiometric coefficient: 1.0

carbovir monophosphate + ATP => carbovir diphosphate + ADP
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence587
xref: UnificationXref3886
xref: UnificationXref3887
left: carbovir monophosphate
left: Adenosine 5'-triphosphate
display name: Phosphorylation of carbovir monophosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: carbovir diphosphate
right: Adenosine 5'-diphosphate

Catalysis41
type: Catalysis
data source: Provenance1
controlled: Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
control type: ACTIVATION
xref: RelationshipXref60
xref: RelationshipXref63
controller: Homologues of SLC28A2

UnificationXref87
type: UnificationXref
id: 4232572
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232572

Stoichiometry3
type: Stoichiometry
physical entity: Double-strand DNA containing an adenine opposite to an 8-oxo guanine
stoichiometric coefficient: 1.0

Chondroitin 6-sulfate chain
type: SmallMolecule
entity reference: CHEBI:63512
data source: Provenance1
xref: UnificationXref1391
xref: UnificationXref1392
cellular location: lysosomal lumen
comment: Reactome DB_ID: 2065246
display name: C6S chain

abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence586
EC number: 3.5.4.4
xref: UnificationXref3881
xref: UnificationXref3882
left: Water
left: abacavir monophosphate
display name: Deamination of abacavir monophosphate to form carbovir monophosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: cyclopropylamine
right: carbovir monophosphate

Catalysis42
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Water into Cells by Aquaporins
control type: ACTIVATION
xref: RelationshipXref64
xref: RelationshipXref65
controller: Aquaporins that transport water across the plasma membrane.

UnificationXref86
type: UnificationXref
id: 4232570
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232570

Stoichiometry4
type: Stoichiometry
physical entity: Protein52
stoichiometric coefficient: 1.0

Catalysis57
type: Catalysis
data source: Provenance1
controlled: SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol
control type: ACTIVATION
xref: RelationshipXref80
xref: RelationshipXref81
controller: Homologues of SLC17A3

Catalysis56
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Glycerol into Cell by Aquaporin-9
control type: ACTIVATION
xref: RelationshipXref78
xref: RelationshipXref68
controller: AQP9 tetramer (name copied from entity in Homo sapiens)

Catalysis59
type: Catalysis
data source: Provenance1
controlled: SLC9C1 exchanges Na+ for H+
control type: ACTIVATION
xref: RelationshipXref33
xref: RelationshipXref84
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis58
type: Catalysis
data source: Provenance1
controlled: SLC17A3-2 transports cytosolic urate to extracellular region
control type: ACTIVATION
xref: RelationshipXref83
xref: RelationshipXref82
controller: Homologues of SLC17A3(1-498)

(R)-2-Hydroxy-3-(phosphonooxy)-1-monoanhydridewith phosphoric propanoic acid
type: SmallMolecule
entity reference: CHEBI:16001
data source: Provenance1
name: 3-Phospho-D-glyceroyl phosphate
xref: UnificationXref1493
xref: UnificationXref1492
cellular location: GO:0005829
comment: Reactome DB_ID: 29800
display name: 1,3-Bisphospho-D-glycerate

The acetyl group from acetyl-CoA is transferred to the NAT2
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence572
evidence: Evidence571
xref: UnificationXref3757
xref: UnificationXref3756
left: Note: the coordinates are copied over from Homo sapiens.
left: Acetyl coenzyme A
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Note: the coordinates are copied over from Homo sapiens.
right: SmallMolecule292

UnificationXref72
type: UnificationXref
id: 4232555
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232555

Cyclic AMP
type: SmallMolecule
entity reference: CHEBI:17489
data source: Provenance1
name: Cyclic adenylic acid
name: Adenosine 3',5'-phosphate
name: 3',5'-Cyclic AMP
xref: UnificationXref1535
xref: UnificationXref1536
cellular location: GO:0005829
comment: Reactome DB_ID: 30389
display name: cAMP

UDP-glucose is oxidised to UDP-glucuronate
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence567
EC number: 1.1.1.22
xref: UnificationXref3744
xref: UnificationXref3745
participant stoichiometry: Stoichiometry366
participant stoichiometry: Stoichiometry365
participant stoichiometry: Stoichiometry367
left: DPN
left: Water
left: UDPglucose
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule385
right: UDP-glucuronic acid
right: proton

UnificationXref71
type: UnificationXref
id: Q46916
db: UniProt

Pyruvate
type: SmallMolecule
entity reference: Pyruvate
data source: Provenance1
name: Pyruvic acid
name: Pyroracemic acid
name: 2-Oxopropanoate
name: 2-Oxopropanoic acid
xref: UnificationXref1525
xref: UnificationXref1526
cellular location: GO:0005829
comment: Reactome DB_ID: 29398
display name: PYR

NAT2 acetylation
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence574
EC number: 2.3.1.5
xref: UnificationXref3805
xref: UnificationXref3804
left: Note: the coordinates are copied over from Homo sapiens.
left: NAT2 substrate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Note: the coordinates are copied over from Homo sapiens.
right: NAT2 acetylated conjugate

UnificationXref74
type: UnificationXref
id: 4232558
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232558

Phosphoenolpyruvic acid
type: SmallMolecule
entity reference: Phosphoenolpyruvic acid
data source: Provenance1
name: Phosphoenolpyruvate
xref: UnificationXref1517
xref: UnificationXref1518
cellular location: GO:0005829
comment: Reactome DB_ID: 29492
display name: PEP

NAT1 acetylation
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence573
EC number: 2.3.1.5
xref: UnificationXref3786
xref: UnificationXref3787
left: NAT1 substrate
left: Note: the coordinates are copied over from Homo sapiens.
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NAT1 acetylated conjugate
right: Note: the coordinates are copied over from Homo sapiens.

UnificationXref73
type: UnificationXref
id: P0AA80
db: UniProt

D-Glycerate 2-phosphate
type: SmallMolecule
entity reference: D-Glycerate 2-phosphate
data source: Provenance1
name: 2-Phospho-D-glycerate
xref: UnificationXref1507
xref: UnificationXref1506
cellular location: GO:0005829
comment: Reactome DB_ID: 30485
display name: 2PG

Pyruvate
type: SmallMolecule
entity reference: Pyruvate
data source: Provenance1
name: Pyruvic acid
name: Pyroracemic acid
name: 2-Oxopropanoate
name: 2-Oxopropanoic acid
xref: UnificationXref1551
xref: UnificationXref1550
cellular location: GO:0005759
comment: Reactome DB_ID: 113557
display name: PYR

Glutathione is hydrolyzed
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence576
EC number: 2.3.2.2
xref: UnificationXref3850
xref: UnificationXref3851
left: gamma-L-Glutamyl-L-cysteinyl-glycine
left: L-Amino Acids
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: cysteine-glycine
right: Complex203

Carbon dioxide
type: SmallMolecule
entity reference: CO2 [ChEBI:16526]
data source: Provenance1
xref: UnificationXref1549
xref: UnificationXref1548
cellular location: GO:0005759
comment: Reactome DB_ID: 29376
display name: CO2

Ubiquinol biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction203
pathway component: BiochemicalReaction206
pathway component: BiochemicalReaction204
pathway component: BiochemicalReaction202
pathway component: BiochemicalReaction205
evidence: Evidence387
xref: UnificationXref2518
xref: UnificationXref2519
xref: RelationshipXref334
pathway order: PathwayStep369
pathway order: PathwayStep372
pathway order: PathwayStep371
pathway order: PathwayStep373
pathway order: PathwayStep370
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref70
type: UnificationXref
id: 4232552
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232552

Acetyl coenzyme A
type: SmallMolecule
entity reference: CHEBI:15351
data source: Provenance1
name: Acetyl-CoA
xref: UnificationXref1543
xref: UnificationXref1542
cellular location: GO:0005829
comment: Reactome DB_ID: 76183
display name: Ac-CoA

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15422
data source: Provenance1
xref: UnificationXref1539
xref: UnificationXref1538
cellular location: nucleoplasm
comment: Reactome DB_ID: 29358
display name: ATP

UnificationXref79
type: UnificationXref
id: 4232563
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232563

Conversion of coproporphyrinogen III to protoporphyrinogen IX
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence558
EC number: 1.3.3.3
xref: UnificationXref3692
xref: UnificationXref3691
participant stoichiometry: Stoichiometry359
participant stoichiometry: Stoichiometry360
participant stoichiometry: Stoichiometry358
left: Coproporphyrinogen III
left: Oxygen
display name: CPO transforms COPRO3 to PPGEN9
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Hydrogen peroxide
right: Carbon dioxide
right: Protoporphyrinogen IX

Catalysis50
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Water into Cell by Aquaporin-1
control type: ACTIVATION
xref: RelationshipXref64
xref: RelationshipXref73
controller: AQP1 tetramer (name copied from entity in Homo sapiens)

Catalysis51
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Water into Cell by Aquaporin-2 Phosphorylated on Serine256
control type: ACTIVATION
xref: RelationshipXref74
xref: RelationshipXref64
controller: p-S256-AQP2 (name copied from entity in Homo sapiens)

COX10 transforms heme to heme O
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence560
xref: UnificationXref3718
xref: UnificationXref3717
left: protoheme
left: FPP
left: SmallMolecule205
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule144
right: heme O

Catalysis52
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Water out of Cell by Aquaporin-1
control type: ACTIVATION
xref: RelationshipXref64
xref: RelationshipXref73
controller: AQP1 tetramer (name copied from entity in Homo sapiens)

UnificationXref76
type: UnificationXref
id: 4232560
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232560

Mg++
type: SmallMolecule
entity reference: CHEBI:18420
data source: Provenance1
name: Magnesium
xref: UnificationXref1498
xref: UnificationXref1499
cellular location: GO:0005829
comment: Reactome DB_ID: 29926
display name: Mg2+

Ferrous iron is inserted into protoporphyrin IX to form heme
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence559
EC number: 4.99.1.1
xref: UnificationXref3704
xref: UnificationXref3705
participant stoichiometry: Stoichiometry362
left: Protoporphyrin IX
left: iron (ferrous)
display name: FECH binds Fe2+ to PRIN9 to form heme
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: protoheme
right: H+

Catalysis53
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Water out of Cell by Aquaporin-3
control type: ACTIVATION
xref: RelationshipXref75
xref: RelationshipXref64
controller: AQP3 tetramer (name copied from entity in Homo sapiens)

UnificationXref75
type: UnificationXref
id: 4232559
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232559

3-Phospho-D-glycerate
type: SmallMolecule
entity reference: 3-Phospho-D-glycerate
data source: Provenance1
name: D-Glycerate 3-phosphate
xref: UnificationXref1496
xref: UnificationXref1495
cellular location: GO:0005829
comment: Reactome DB_ID: 29728
display name: 3PG

acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence564
EC number: 6.2.1.1
xref: UnificationXref3733
xref: UnificationXref3732
left: Acetate
left: SmallMolecule292
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule139
right: SmallMolecule137
right: Acetyl coenzyme A

Catalysis54
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Water out of Cell by Aquaporin-4
control type: ACTIVATION
xref: RelationshipXref76
xref: RelationshipXref64
controller: AQP4 tetramer (name copied from entity in Homo sapiens)

UnificationXref78
type: UnificationXref
id: 4232562
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232562

acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]
type: BiochemicalReaction
data source: Provenance1
evidence: Evidence563
EC number: 6.2.1.1
xref: UnificationXref3728
xref: UnificationXref3727
left: SmallMolecule140
left: SmallMolecule299
left: Acetate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule143
right: Acetyl coenzyme A
right: SmallMolecule144

Catalysis55
type: Catalysis
data source: Provenance1
controlled: Passive Transport of Glycerol out of Cell by Aquaporin-7
control type: ACTIVATION
xref: RelationshipXref77
xref: RelationshipXref68
controller: AQP7 tetramer (name copied from entity in Homo sapiens)

UnificationXref77
type: UnificationXref
id: 4232561
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232561

Catalysis29
type: Catalysis
data source: Provenance1
controlled: Transport (influx) of glucose, galactose, and sodium ions by SGLT1
control type: ACTIVATION
xref: RelationshipXref42
xref: RelationshipXref43
controller: Protein79

Catalysis27
type: Catalysis
data source: Provenance1
controlled: Electroneutral Na+/Pi cotransport
control type: ACTIVATION
xref: RelationshipXref7
xref: RelationshipXref39
controller: Protein72

Catalysis28
type: Catalysis
data source: Provenance1
controlled: Type III Na+/Pi cotransport
control type: ACTIVATION
xref: RelationshipXref7
xref: RelationshipXref40
controller: PhysicalEntity14

Catalysis25
type: Catalysis
data source: Provenance1
controlled: Na+/H+ exchanger transport (at late endosome membrane)
control type: ACTIVATION
xref: RelationshipXref37
xref: RelationshipXref33
controller: Protein68

Catalysis26
type: Catalysis
data source: Provenance1
controlled: Electrogenic Na+/Pi cotransport
control type: ACTIVATION
xref: RelationshipXref7
xref: RelationshipXref38
controller: Protein69

Catalysis23
type: Catalysis
data source: Provenance1
controlled: Na+/H+ exchanger transport (at early endosome membrane)
control type: ACTIVATION
xref: RelationshipXref33
xref: RelationshipXref35
controller: Protein64

Catalysis24
type: Catalysis
data source: Provenance1
controlled: Na+/H+ exchanger transport (at trans-golgi membrane)
control type: ACTIVATION
xref: RelationshipXref36
xref: RelationshipXref33
controller: Protein65

UnificationXref66
type: UnificationXref
id: GO:0005622
db: GENE ONTOLOGY

Catalysis22
type: Catalysis
data source: Provenance1
controlled: Na+/H+ exchanger transport (at cell membrane)
control type: ACTIVATION
xref: RelationshipXref33
xref: RelationshipXref34
controller: Protein58

UnificationXref67
type: UnificationXref
id: P39398
db: UniProt

Catalysis21
type: Catalysis
data source: Provenance1
controlled: ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes
control type: ACTIVATION
xref: RelationshipXref30
xref: RelationshipXref31
controller: ABCD1/2/3 dimers

UnificationXref64
type: UnificationXref
id: 428614
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428614

Catalysis20
type: Catalysis
data source: Provenance1
controlled: BiochemicalReaction29
control type: ACTIVATION
xref: RelationshipXref21
xref: RelationshipXref23
controller: Protein53

UnificationXref65
type: UnificationXref
id: REACT_19547
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19547.2

UnificationXref68
type: UnificationXref
id: 4232549
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4232549

UnificationXref69
type: UnificationXref
id: P0AA76
db: UniProt

UnificationXref62
type: UnificationXref
id: 428548
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428548