tRNA(Cys)
type: SmallMolecule
entity reference: CHEBI:29167
data source: Reactome
xref: UnificationXref4631
xref: UnificationXref4632
cellular location: GO:0005829
comment: Reactome DB_ID: 379725

Asp-tRNA(Asp)
type: SmallMolecule
entity reference: CHEBI:29158
data source: Reactome
xref: UnificationXref4626
xref: UnificationXref4627
cellular location: GO:0005829
comment: Reactome DB_ID: 379707

tRNA(Glu)
type: SmallMolecule
entity reference: CHEBI:29175
data source: Reactome
xref: UnificationXref4642
xref: UnificationXref4643
cellular location: GO:0005829
comment: Reactome DB_ID: 379778

Cys-tRNA(Cys)
type: SmallMolecule
entity reference: CHEBI:29152
data source: Reactome
xref: UnificationXref4635
xref: UnificationXref4634
cellular location: GO:0005829
comment: Reactome DB_ID: 379719

PLC-mediated hydrolysis of PIP2
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction1145
evidence: Evidence3498
xref: UnificationXref32992
xref: UnificationXref32993
pathway order: PathwayStep1766
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

tRNA(Gln)
type: SmallMolecule
entity reference: CHEBI:29168
data source: Reactome
xref: UnificationXref4651
xref: UnificationXref4650
cellular location: GO:0005829
comment: Reactome DB_ID: 379748

Glu-tRNA(Glu)
type: SmallMolecule
entity reference: CHEBI:29157
data source: Reactome
xref: UnificationXref4645
xref: UnificationXref4646
cellular location: GO:0005829
comment: Reactome DB_ID: 379751

tRNA(Gly)
type: SmallMolecule
entity reference: CHEBI:29176
data source: Reactome
xref: UnificationXref4658
xref: UnificationXref4659
cellular location: GO:0005829
comment: Reactome DB_ID: 379766

Gln-tRNA(Gln)
type: SmallMolecule
entity reference: CHEBI:29166
data source: Reactome
xref: UnificationXref4653
xref: UnificationXref4654
cellular location: GO:0005829
comment: Reactome DB_ID: 379772

tRNA(Asn)
type: SmallMolecule
entity reference: CHEBI:29172
data source: Reactome
xref: UnificationXref4613
xref: UnificationXref4614
cellular location: GO:0005829
comment: Reactome DB_ID: 379722

Asn-tRNA(Asn)
type: SmallMolecule
entity reference: CHEBI:29265
data source: Reactome
xref: UnificationXref4616
xref: UnificationXref4617
cellular location: GO:0005829
comment: Reactome DB_ID: 379728

tRNA(Asp)
type: SmallMolecule
entity reference: CHEBI:29186
data source: Reactome
xref: UnificationXref4624
xref: UnificationXref4623
cellular location: GO:0005829
comment: Reactome DB_ID: 379711

tRNA(Ala)
type: SmallMolecule
entity reference: CHEBI:17732
data source: Reactome
xref: UnificationXref4551
xref: UnificationXref4552
cellular location: GO:0005829
comment: Reactome DB_ID: 379731

NH3
type: SmallMolecule
entity reference: CHEBI:16134
data source: Reactome
xref: UnificationXref4540
xref: UnificationXref4541
cellular location: GO:0005654
comment: Reactome DB_ID: 76230

S-adenosylhomocysteine
type: SmallMolecule
entity reference: CHEBI:16680
data source: Reactome
name: S-adenosyl-L-homocysteine
xref: UnificationXref3818
xref: UnificationXref3819
cellular location: GO:0005654
comment: Reactome DB_ID: 77502
display name: AdoHcy

Arg-tRNA(Arg)
type: SmallMolecule
entity reference: CHEBI:18366
data source: Reactome
xref: UnificationXref4566
xref: UnificationXref4567
cellular location: GO:0005829
comment: Reactome DB_ID: 379720

tRNA(Arg)
type: SmallMolecule
entity reference: CHEBI:29171
data source: Reactome
xref: UnificationXref4563
xref: UnificationXref4564
cellular location: GO:0005829
comment: Reactome DB_ID: 379704

Ala-tRNA(Ala)
type: SmallMolecule
entity reference: CHEBI:17732
data source: Reactome
xref: UnificationXref4557
xref: UnificationXref4556
cellular location: GO:0005829
comment: Reactome DB_ID: 379700

5'-Adenylic acid
type: SmallMolecule
entity reference: CHEBI:16027
data source: Reactome
name: Adenylate
name: Adenosine 5'-phosphate
name: 5'-AMP
name: 5'-Adenosine monophosphate
name: adenosine 5'-monophosphate
name: Adenylic acid
xref: UnificationXref4554
xref: UnificationXref4555
cellular location: GO:0005829
comment: Reactome DB_ID: 76577
display name: AMP

http://identifiers.org/pubmed/9809442
type: PublicationXref
id: 9809442
author: Marin-Garcia, J
author: Ananthakrishnan, R
author: Goldenthal, MJ
db: Pubmed
title: Cloning and molecular analysis of the human citrate synthase gene
source: Genome 41:733-738
year: 1998

GDP
type: SmallMolecule
entity reference: CHEBI:17552
data source: Reactome
xref: UnificationXref3801
xref: UnificationXref3800
cellular location: GO:0005654
comment: Reactome DB_ID: 111349

S-adenosylmethionine
type: SmallMolecule
entity reference: CHEBI:15414
data source: Reactome
xref: UnificationXref3815
xref: UnificationXref3816
cellular location: GO:0005654
comment: Reactome DB_ID: 77087
display name: AdoMet

diphosphate
type: SmallMolecule
entity reference: CHEBI:29888
data source: Reactome
name: pyrophosphoric acid
name: pyrophosphate
xref: UnificationXref3492
xref: UnificationXref3491
cellular location: GO:0005654
comment: Reactome DB_ID: 113541
display name: PPi

Guanosine monophosphate
type: SmallMolecule
entity reference: CHEBI:17345
data source: Reactome
name: Guanosine 5'-phosphate
name: Guanylic acid
name: Guanosine 5'-monophosphate
xref: UnificationXref3795
xref: UnificationXref3796
cellular location: GO:0005654
comment: Reactome DB_ID: 29626
display name: GMP

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15996
data source: Reactome
xref: UnificationXref3032
xref: UnificationXref3033
cellular location: GO:0005654
comment: Reactome DB_ID: 113571
display name: GTP

cytidine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:17677
data source: Reactome
name: Cytidine triphosphate
xref: UnificationXref3031
xref: UnificationXref3030
cellular location: GO:0005654
comment: Reactome DB_ID: 29470
display name: CTP

NDP
type: SmallMolecule
entity reference: CHEBI:16862
data source: Reactome
xref: UnificationXref3201
xref: UnificationXref3202
cellular location: GO:0005654
comment: Reactome DB_ID: 30181

uridine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15713
data source: Reactome
name: Uridine triphosphate
xref: UnificationXref3036
xref: UnificationXref3035
cellular location: GO:0005654
comment: Reactome DB_ID: 113562
display name: UTP

NTP
type: SmallMolecule
data source: Reactome
member physical entity: uridine 5'-triphosphate
member physical entity: cytidine 5'-triphosphate
member physical entity: Adenosine 5'-triphosphate
member physical entity: Guanosine 5'-triphosphate
xref: UnificationXref3038
xref: UnificationXref3037
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 30595

Acetyl coenzyme A
type: SmallMolecule
entity reference: CHEBI:15351
data source: Reactome
name: Acetyl-CoA
xref: UnificationXref3012
xref: UnificationXref3013
cellular location: GO:0005654
comment: Reactome DB_ID: 113560
display name: Ac-CoA

Phosphate
type: SmallMolecule
entity reference: CHEBI:18367
data source: Reactome
name: Orthophosphate
name: Inorganic Phosphate
xref: UnificationXref2910
xref: UnificationXref2911
cellular location: GO:0005654
comment: Reactome DB_ID: 113550
display name: Pi

Cyclic AMP
type: SmallMolecule
entity reference: CHEBI:17489
data source: Reactome
name: Cyclic adenylic acid
name: Adenosine 3',5'-phosphate
name: 3',5'-Cyclic AMP
xref: UnificationXref1647
xref: UnificationXref1646
cellular location: GO:0005829
comment: Reactome DB_ID: 30389
display name: cAMP

DPN
type: SmallMolecule
entity reference: CHEBI:15846
data source: Reactome
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref2864
xref: UnificationXref2865
cellular location: GO:0005654
comment: Reactome DB_ID: 427523
display name: NAD

Nicotinamide
type: SmallMolecule
entity reference: CHEBI:17154
data source: Reactome
xref: UnificationXref2868
xref: UnificationXref2867
cellular location: GO:0005654
comment: Reactome DB_ID: 427497
display name: NAM

Water
type: SmallMolecule
entity reference: CHEBI:15377
data source: Reactome
xref: UnificationXref2899
xref: UnificationXref2900
cellular location: GO:0005654
comment: Reactome DB_ID: 113518
display name: H2O

http://identifiers.org/pubmed/642006
type: PublicationXref
id: 642006
author: Gall, JG
author: Blackburn, EH
db: Pubmed
title: A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena
source: J Mol Biol 120:33-53
year: 1978

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:16761
data source: Reactome
xref: UnificationXref1613
xref: UnificationXref1614
cellular location: GO:0005654
comment: Reactome DB_ID: 113582
display name: ADP

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15422
data source: Reactome
xref: UnificationXref1611
xref: UnificationXref1612
cellular location: GO:0005654
comment: Reactome DB_ID: 29358
display name: ATP

ADP
type: SmallMolecule
entity reference: CHEBI:16761
data source: Reactome
xref: UnificationXref1544
xref: UnificationXref1543
cellular location: GO:0005886
comment: Reactome DB_ID: 196180

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15996
data source: Reactome
xref: UnificationXref1534
xref: UnificationXref1535
cellular location: GO:0005886
comment: Reactome DB_ID: 113572
display name: GTP

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15422
data source: Reactome
xref: UnificationXref1533
xref: UnificationXref1532
cellular location: GO:0005886
comment: Reactome DB_ID: 139836
display name: ATP

Calcium
type: SmallMolecule
entity reference: CHEBI:29108
data source: Reactome
xref: UnificationXref1512
xref: UnificationXref1511
cellular location: GO:0005576
comment: Reactome DB_ID: 74112
display name: Ca2+

Calcium
type: SmallMolecule
entity reference: CHEBI:29108
data source: Reactome
xref: UnificationXref1514
xref: UnificationXref1513
cellular location: GO:0005829
comment: Reactome DB_ID: 74016
display name: Ca2+

3-O-sn-Phosphatidyl-L-serine
type: SmallMolecule
entity reference: SmallMoleculeReference58
data source: Reactome
name: 1,2-Diacyl-sn-glycerol 3-phospho-L-serine
name: Phosphatidyl-L-serine
name: O3-Phosphatidyl-L-serine
xref: UnificationXref1458
xref: UnificationXref1459
cellular location: GO:0005886
comment: Reactome DB_ID: 33625
display name: Phosphatidylserine

Calcium
type: SmallMolecule
entity reference: CHEBI:29108
data source: Reactome
xref: UnificationXref1462
xref: UnificationXref1461
cellular location: GO:0005886
comment: Reactome DB_ID: 140648
display name: Ca2+

NH4+
type: SmallMolecule
entity reference: CHEBI:28938
data source: Reactome
xref: UnificationXref1344
xref: UnificationXref1343
cellular location: GO:0005829
comment: Reactome DB_ID: 31633

1,2-Diacylglycerol
type: SmallMolecule
entity reference: SmallMoleculeReference57
data source: Reactome
xref: UnificationXref1456
xref: UnificationXref1455
cellular location: GO:0005886
comment: Reactome DB_ID: 114519
display name: DAG

http://identifiers.org/pubmed/9438390
type: PublicationXref
id: 9438390
author: Webster, MK
author: Bardwell, WM
author: Meyer, AN
author: Donoghue, DJ
author: Robertson, SC
author: d'Avis, PY
db: Pubmed
title: Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I
source: Cell Growth Differ 9:71-8
year: 1998

UniProt:Q9GQV2
type: ProteinReference
xref: UnificationXref17957
organism: BioSource1

UniProt:Q9GQV1
type: ProteinReference
xref: UnificationXref17945
organism: BioSource1

http://identifiers.org/pubmed/3954355
type: PublicationXref
id: 3954355
author: Bergholte, JM
author: Okita, RT
db: Pubmed
title: Isolation and properties of lung 15-hydroxyprostaglandin dehydrogenase from pregnant rabbits
source: Arch Biochem Biophys 245:308-15
year: 1986

http://identifiers.org/pubmed/9188485
type: PublicationXref
id: 9188485
author: Folk, JE
author: Park, MH
author: Wolff, EC
db: Pubmed
title: Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase
source: J Biol Chem 272:15865-71
year: 1997

7,8-dihydro-7-hydroxy-8S-glutathionylbenzo[a]pyrene
type: SmallMoleculeReference
name: 7,8-dihydro-7-hydroxy-8S-glutathionylbenzo[a]pyrene [ChEBI:34479]
name: 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
xref: UnificationXref27892

Phe-tRNA(Phe)
type: SmallMolecule
entity reference: CHEBI:29153
data source: Reactome
xref: UnificationXref4723
xref: UnificationXref4722
cellular location: GO:0005829
comment: Reactome DB_ID: 379792

tRNA(Pro)
type: SmallMolecule
entity reference: CHEBI:29177
data source: Reactome
xref: UnificationXref4732
xref: UnificationXref4733
cellular location: GO:0005829
comment: Reactome DB_ID: 379768

Thr-tRNA(Thr)
type: SmallMolecule
entity reference: CHEBI:29163
data source: Reactome
xref: UnificationXref4758
xref: UnificationXref4757
cellular location: GO:0005829
comment: Reactome DB_ID: 379783

tRNA(Trp)
type: SmallMolecule
entity reference: CHEBI:29181
data source: Reactome
xref: UnificationXref4773
xref: UnificationXref4772
cellular location: GO:0005829
comment: Reactome DB_ID: 379763

http://identifiers.org/pubmed/9188469
type: PublicationXref
id: 9188469
author: Cupillard, L
author: Matteï, MG
author: Koumanov, K
author: Lazdunski, M
author: Lambeau, G
db: Pubmed
title: Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2
source: J Biol Chem 272:15745-52
year: 1997

Trp-tRNA(Trp)
type: SmallMolecule
entity reference: CHEBI:29159
data source: Reactome
xref: UnificationXref4775
xref: UnificationXref4776
cellular location: GO:0005829
comment: Reactome DB_ID: 379765

tRNA(Tyr)
type: SmallMolecule
entity reference: CHEBI:29182
data source: Reactome
xref: UnificationXref4789
xref: UnificationXref4788
cellular location: GO:0005829
comment: Reactome DB_ID: 379743

Pro-tRNA(Pro)
type: SmallMolecule
entity reference: CHEBI:29154
data source: Reactome
xref: UnificationXref4736
xref: UnificationXref4735
cellular location: GO:0005829
comment: Reactome DB_ID: 379746

tRNA(Ser)
type: SmallMolecule
entity reference: CHEBI:29179
data source: Reactome
xref: UnificationXref4740
xref: UnificationXref4741
cellular location: GO:0005829
comment: Reactome DB_ID: 379762

Ser-tRNA(Ser)
type: SmallMolecule
entity reference: CHEBI:29162
data source: Reactome
xref: UnificationXref4743
xref: UnificationXref4744
cellular location: GO:0005829
comment: Reactome DB_ID: 379738

tRNA(Thr)
type: SmallMolecule
entity reference: CHEBI:29180
data source: Reactome
xref: UnificationXref4755
xref: UnificationXref4754
cellular location: GO:0005829
comment: Reactome DB_ID: 379749

tRNA(Phe)
type: SmallMolecule
entity reference: CHEBI:29184
data source: Reactome
xref: UnificationXref4720
xref: UnificationXref4719
cellular location: GO:0005829
comment: Reactome DB_ID: 379767

http://identifiers.org/pubmed/1371749
type: PublicationXref
id: 1371749
author: Saxty, BA
author: Groot, PH
author: Kmetz, PJ
author: Near, JC
author: Hughes, SA
author: Franklin, M
author: Wells, TN
author: Gloger, IS
author: Elshourbagy, NA
db: Pubmed
title: Cloning and expression of a human ATP-citrate lyase cDNA
source: Eur J Biochem 204:491-9
year: 1992

His-tRNA(His)
type: SmallMolecule
entity reference: CHEBI:29155
data source: Reactome
xref: UnificationXref4678
xref: UnificationXref4677
cellular location: GO:0005829
comment: Reactome DB_ID: 379786

(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
type: SmallMoleculeReference
name: ChEBI:34496 9(S')-HODE
name: 9(S')-HODE
xref: UnificationXref13814

tRNA(Met)
type: SmallMolecule
entity reference: CHEBI:29173
data source: Reactome
xref: UnificationXref4711
xref: UnificationXref4712
cellular location: GO:0005829
comment: Reactome DB_ID: 379742

Met-tRNA(Met)
type: SmallMolecule
entity reference: CHEBI:16635
data source: Reactome
xref: UnificationXref4715
xref: UnificationXref4714
cellular location: GO:0005829
comment: Reactome DB_ID: 379794

tRNA(Lys)
type: SmallMolecule
entity reference: CHEBI:29185
data source: Reactome
xref: UnificationXref4704
xref: UnificationXref4703
cellular location: GO:0005829
comment: Reactome DB_ID: 379776

Lys-tRNA(Lys)
type: SmallMolecule
entity reference: CHEBI:16047
data source: Reactome
xref: UnificationXref4707
xref: UnificationXref4706
cellular location: GO:0005829
comment: Reactome DB_ID: 379736

tRNA(Leu)
type: SmallMolecule
entity reference: CHEBI:29169
data source: Reactome
xref: UnificationXref4695
xref: UnificationXref4696
cellular location: GO:0005829
comment: Reactome DB_ID: 379771

Leu-tRNA(Leu)
type: SmallMolecule
entity reference: CHEBI:16624
data source: Reactome
xref: UnificationXref4699
xref: UnificationXref4698
cellular location: GO:0005829
comment: Reactome DB_ID: 379757

8,9-EpETrE [ChEBI:34490]
type: SmallMoleculeReference
name: 8,9-EpETrE
xref: UnificationXref23943

tRNA(Ile)
type: SmallMolecule
entity reference: CHEBI:29174
data source: Reactome
xref: UnificationXref4687
xref: UnificationXref4688
cellular location: GO:0005829
comment: Reactome DB_ID: 379739

Ile-tRNA(Ile)
type: SmallMolecule
entity reference: CHEBI:29160
data source: Reactome
xref: UnificationXref4690
xref: UnificationXref4691
cellular location: GO:0005829
comment: Reactome DB_ID: 379787

tRNA(His)
type: SmallMolecule
entity reference: CHEBI:29178
data source: Reactome
xref: UnificationXref4675
xref: UnificationXref4674
cellular location: GO:0005829
comment: Reactome DB_ID: 379758

Gly-tRNA(Gly)
type: SmallMolecule
entity reference: CHEBI:29156
data source: Reactome
xref: UnificationXref4662
xref: UnificationXref4661
cellular location: GO:0005829
comment: Reactome DB_ID: 379784

UniProt:Q9GQS3
type: ProteinReference
xref: UnificationXref13702
organism: BioSource1

http://identifiers.org/pubmed/17726023
type: PublicationXref
id: 17726023
author: Florio, V
author: Uher, L
author: Wolda, SL
author: Radwanski, PB
author: McCaw, KN
author: Hambleton, R
author: Vandeput, F
author: Krall, J
author: Movsesian, MA
db: Pubmed
title: Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes
source: J Biol Chem 282:32749-57
year: 2007

http://identifiers.org/pubmed/18382465
type: PublicationXref
id: 18382465
author: Moss, SJ
author: Jurd, R
author: Jacob, TC
db: Pubmed
title: GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition
source: Nat Rev Neurosci 9:331-43
year: 2008

UnificationXref15897
type: UnificationXref
id: Q95028
db: UniProt

UnificationXref15896
type: UnificationXref
id: REACT_123852
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123852.1

UniProt:Q9GR11
type: ProteinReference
xref: UnificationXref9607
organism: BioSource1

UnificationXref15899
type: UnificationXref
id: A1Z9F8
db: UniProt

UnificationXref15898
type: UnificationXref
id: 4142078
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4142078

UnificationXref15893
type: UnificationXref
id: REACT_132491
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132491.5

UnificationXref15892
type: UnificationXref
id: 4172559
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172559

UnificationXref15895
type: UnificationXref
id: 2160481
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2160481

UniProt:Q9GQP6
type: ProteinReference
xref: UnificationXref13729
organism: BioSource1

UnificationXref15894
type: UnificationXref
id: CHEBI:8100
db: ChEBI

UnificationXref15891
type: UnificationXref
id: 4162936
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4162936

UnificationXref15890
type: UnificationXref
id: 4162935
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4162935

http://identifiers.org/pubmed/18555844
type: PublicationXref
id: 18555844
author: Buehrer, B
author: Madan, AK
author: Fain, JN
author: Bahouth, SW
author: Tichansky, DS
db: Pubmed
title: Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue
source: Metabolism 57:1005-15
year: 2008

5,6-EpETrE [ChEBI:34450]
type: SmallMoleculeReference
name: 5,6-EpETrE
xref: UnificationXref23935

C6 deamination of adenosine
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction235
evidence: Evidence360
xref: UnificationXref4545
xref: UnificationXref4544
pathway order: PathwayStep352
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Sulfide oxidation to sulfate
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction1996
pathway component: BiochemicalReaction1997
pathway component: Sulfate is exported to the cytosol in exchange for dicarboxylate
pathway component: BiochemicalReaction1998
evidence: Evidence2872
xref: UnificationXref27349
xref: RelationshipXref1953
xref: UnificationXref27348
pathway order: PathwayStep2866
pathway order: PathwayStep2865
pathway order: PathwayStep7
pathway order: PathwayStep2864
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:Q9GQM7
type: ProteinReference
xref: UnificationXref1375
organism: BioSource1

UniProt:Q9GQM8
type: ProteinReference
xref: UnificationXref18653
organism: BioSource1

Post-transcriptional Silencing By Small RNAs
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction295
pathway component: BiochemicalReaction293
pathway component: BiochemicalReaction294
evidence: Evidence436
xref: UnificationXref5495
xref: UnificationXref5496
pathway order: PathwayStep427
pathway order: PathwayStep428
pathway order: PathwayStep426
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11907280
type: PublicationXref
id: 11907280
author: Hagting, A
author: Pines, J
author: Jackman, M
author: Kubota, Y
author: Den Elzen, N
db: Pubmed
title: Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm
source: Mol Biol Cell 13:1030-45
year: 2002

SequenceSite11921
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11920
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11923
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11922
type: SequenceSite
position status: EQUAL
sequence position: 4391

http://identifiers.org/pubmed/14528307
type: PublicationXref
id: 14528307
author: Kim, SY
author: Anderson, KV
author: Li, MZ
author: Carmell, MA
author: Mills, AA
author: Elledge, SJ
author: Hannon, GJ
author: Murchison, EP
author: Bernstein, E
author: Alcorn, H
db: Pubmed
title: Dicer is essential for mouse development
source: Nat Genet 35:215-7
year: 2003

SequenceSite11925
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11924
type: SequenceSite
position status: EQUAL
sequence position: 4391

UnificationXref15959
type: UnificationXref
id: REACT_90799
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90799.9

SequenceSite11927
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11926
type: SequenceSite
position status: EQUAL
sequence position: 4391

UnificationXref15957
type: UnificationXref
id: REACT_125729
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125729.5

SequenceSite11929
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref15958
type: UnificationXref
id: 4175376
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175376

SequenceSite11928
type: SequenceSite
position status: EQUAL
sequence position: 4391

UnificationXref15955
type: UnificationXref
id: 4162585
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4162585

UnificationXref15956
type: UnificationXref
id: 4162587
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4162587

UnificationXref15954
type: UnificationXref
id: 4162584
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4162584

UnificationXref15953
type: UnificationXref
id: Q9VVD9
db: UniProt

UnificationXref15952
type: UnificationXref
id: 4162580
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4162580

UnificationXref15951
type: UnificationXref
id: Q9VEI3
db: UniProt

UnificationXref15950
type: UnificationXref
id: REACT_22655
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22655.1

SequenceSite11930
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11934
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11933
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11932
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11931
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11938
type: SequenceSite
position status: EQUAL
sequence position: 201

SequenceSite11937
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11936
type: SequenceSite
position status: EQUAL
sequence position: 310

SequenceSite11935
type: SequenceSite
position status: EQUAL
sequence position: 18

UnificationXref15966
type: UnificationXref
id: 744227
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=744227

UnificationXref15967
type: UnificationXref
id: REACT_23102
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23102.2

UnificationXref15968
type: UnificationXref
id: 744234
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=744234

UnificationXref15969
type: UnificationXref
id: REACT_23127
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23127.2

SequenceSite11939
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref15963
type: UnificationXref
id: REACT_23247
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23247.2

UnificationXref15962
type: UnificationXref
id: 744229
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=744229

UnificationXref15965
type: UnificationXref
id: REACT_22710
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22710.1

UnificationXref15964
type: UnificationXref
id: 735698
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=735698

UnificationXref15961
type: UnificationXref
id: REACT_22968
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22968.1

UnificationXref15960
type: UnificationXref
id: 741437
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=741437

SequenceSite11901
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite11900
type: SequenceSite
position status: EQUAL
sequence position: 530

http://identifiers.org/pubmed/15534001
type: PublicationXref
id: 15534001
author: Allison, JG
author: Williams, CC
author: Beckman, BS
author: Jones, FE
author: Vidal, GA
author: Burow, ME
author: Marrero, L
db: Pubmed
title: The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
source: J Cell Biol 167:469-78
year: 2004

UnificationXref15935
type: UnificationXref
id: 4150033
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150033

SequenceSite11907
type: SequenceSite
position status: EQUAL
sequence position: 25

UnificationXref15936
type: UnificationXref
id: 4150034
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150034

SequenceSite11906
type: SequenceSite
position status: EQUAL
sequence position: 554

UnificationXref15933
type: UnificationXref
id: 4150031
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150031

SequenceSite11909
type: SequenceSite
position status: EQUAL
sequence position: 19

UnificationXref15934
type: UnificationXref
id: 4150032
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150032

SequenceSite11908
type: SequenceSite
position status: EQUAL
sequence position: -1

UnificationXref15939
type: UnificationXref
id: 4150037
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150037

SequenceSite11903
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite11902
type: SequenceSite
position status: EQUAL
sequence position: 530

UnificationXref15937
type: UnificationXref
id: 4150035
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150035

SequenceSite11905
type: SequenceSite
position status: EQUAL
sequence position: 24

UnificationXref15938
type: UnificationXref
id: 4150036
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150036

SequenceSite11904
type: SequenceSite
position status: EQUAL
sequence position: 554

UnificationXref15932
type: UnificationXref
id: Q7KUT8
db: UniProt

UnificationXref15931
type: UnificationXref
id: 4150029
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150029

http://identifiers.org/pubmed/12445824
type: PublicationXref
id: 12445824
author: Ganapathy, V
author: Inoue, K
author: Zhuang, L
db: Pubmed
title: Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function
source: Biochem Biophys Res Commun 299:465-71
year: 2002

UnificationXref15930
type: UnificationXref
id: Q961A8
db: UniProt

http://identifiers.org/pubmed/12445829
type: PublicationXref
id: 12445829
author: Visser, WF
author: van Roermund, CW
author: Waterham, HR
author: Wanders, RJ
db: Pubmed
title: Identification of human PMP34 as a peroxisomal ATP transporter
source: Biochem Biophys Res Commun 299:494-7
year: 2002

SequenceSite11912
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite11911
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11910
type: SequenceSite
position status: EQUAL
sequence position: 529

UnificationXref15944
type: UnificationXref
id: CHEBI:17980
db: ChEBI

UnificationXref15945
type: UnificationXref
id: 158471
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158471

SequenceSite11919
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref15946
type: UnificationXref
id: REACT_7132
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7132.1

SequenceSite11918
type: SequenceSite
position status: EQUAL
sequence position: 4391

UnificationXref15947
type: UnificationXref
id: 4150041
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150041

SequenceSite11917
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref15948
type: UnificationXref
id: REACT_90920
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90920.9

SequenceSite11916
type: SequenceSite
position status: EQUAL
sequence position: 529

UnificationXref15949
type: UnificationXref
id: 741440
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=741440

SequenceSite11915
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite11914
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite11913
type: SequenceSite
position status: EQUAL
sequence position: 24

UnificationXref15941
type: UnificationXref
id: 4150039
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150039

UnificationXref15940
type: UnificationXref
id: 4150038
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150038

UnificationXref15943
type: UnificationXref
id: REACT_86638
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86638.9

UnificationXref15942
type: UnificationXref
id: 4150053
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150053

SequenceSite11968
type: SequenceSite
position status: EQUAL
sequence position: 530

SequenceSite11969
type: SequenceSite
position status: EQUAL
sequence position: 24

UnificationXref15999
type: UnificationXref
id: 2105012
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2105012

SequenceSite11960
type: SequenceSite
position status: EQUAL
sequence position: 323

SequenceSite11961
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11962
type: SequenceSite
position status: EQUAL
sequence position: 335

SequenceSite11963
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11964
type: SequenceSite
position status: EQUAL
sequence position: 335

SequenceSite11965
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11966
type: SequenceSite
position status: EQUAL
sequence position: 335

SequenceSite11967
type: SequenceSite
position status: EQUAL
sequence position: 24

UnificationXref15990
type: UnificationXref
id: Q9VGE7
db: UniProt

UnificationXref15997
type: UnificationXref
id: REACT_116559
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116559.2

UnificationXref15998
type: UnificationXref
id: CHEBI:63852
db: ChEBI

UnificationXref15995
type: UnificationXref
id: REACT_130411
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130411.5

UnificationXref15996
type: UnificationXref
id: 1606845
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1606845

UnificationXref15993
type: UnificationXref
id: 4167936
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4167936

UnificationXref15994
type: UnificationXref
id: 4168052
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168052

UnificationXref15991
type: UnificationXref
id: 4167934
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4167934

UnificationXref15992
type: UnificationXref
id: 4167935
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4167935

SequenceSite11979
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11973
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite11974
type: SequenceSite
position status: EQUAL
sequence position: 554

SequenceSite11971
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite11972
type: SequenceSite
position status: EQUAL
sequence position: 554

SequenceSite11977
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11978
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite11975
type: SequenceSite
position status: EQUAL
sequence position: 25

SequenceSite11976
type: SequenceSite
position status: EQUAL
sequence position: -1

SequenceSite11970
type: SequenceSite
position status: EQUAL
sequence position: 530

UnificationXref15979
type: UnificationXref
id: CHEBI:63850
db: ChEBI

UnificationXref15978
type: UnificationXref
id: REACT_117033
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117033.1

UnificationXref15977
type: UnificationXref
id: 1605715
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1605715

MEK activation
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction471
pathway component: REACT 157767.3
evidence: Evidence737
xref: UnificationXref8152
xref: UnificationXref8153
xref: RelationshipXref437
pathway order: PathwayStep726
pathway order: PathwayStep723
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite11946
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite11947
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite11948
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite11949
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11942
type: SequenceSite
position status: EQUAL
sequence position: 198

SequenceSite11943
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite11944
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite11945
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite11940
type: SequenceSite
position status: EQUAL
sequence position: 442

SequenceSite11941
type: SequenceSite
position status: EQUAL
sequence position: 19

UnificationXref15971
type: UnificationXref
id: 4162616
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4162616

UnificationXref15972
type: UnificationXref
id: 4162619
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4162619

UnificationXref15970
type: UnificationXref
id: Q95YI5
db: UniProt

UnificationXref15975
type: UnificationXref
id: REACT_167460
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_167460.1

UnificationXref15976
type: UnificationXref
id: GO:0043202
db: GENE ONTOLOGY

http://identifiers.org/pubmed/12474143
type: PublicationXref
id: 12474143
author: Carlson, Christopher G
author: Hoffbuhr, Kristen C
author: Kennaway, Nancy G
author: Glerum, D Moira
author: Antonicka, Hana
author: Leary, Scot C
author: Shoubridge, EA
author: Mattman, Andre
db: Pubmed
title: Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy
source: Am. J. Hum. Genet. 72:101-14
year: 2003

UnificationXref15973
type: UnificationXref
id: REACT_145117
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145117.5

UnificationXref15974
type: UnificationXref
id: 4175723
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175723

UnificationXref15989
type: UnificationXref
id: 4167930
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4167930

UnificationXref15988
type: UnificationXref
id: Q9VMJ5
db: UniProt

SequenceSite11959
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11957
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11958
type: SequenceSite
position status: EQUAL
sequence position: 323

SequenceSite11955
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11956
type: SequenceSite
position status: EQUAL
sequence position: 323

SequenceSite11953
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11954
type: SequenceSite
position status: EQUAL
sequence position: 334

SequenceSite11951
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11952
type: SequenceSite
position status: EQUAL
sequence position: 334

SequenceSite11950
type: SequenceSite
position status: EQUAL
sequence position: 334

UnificationXref15980
type: UnificationXref
id: 2104997
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2104997

UnificationXref15981
type: UnificationXref
id: REACT_122540
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122540.1

UnificationXref15982
type: UnificationXref
id: CHEBI:28061
db: ChEBI

UnificationXref15983
type: UnificationXref
id: 1605637
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1605637

UnificationXref15984
type: UnificationXref
id: REACT_116807
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116807.1

UnificationXref15985
type: UnificationXref
id: CHEBI:63851
db: ChEBI

UnificationXref15986
type: UnificationXref
id: 2104995
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2104995

UnificationXref15987
type: UnificationXref
id: REACT_123830
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123830.1

http://identifiers.org/pubmed/20215114
type: PublicationXref
id: 20215114
author: Czirják, G
author: Enyedi, P
db: Pubmed
title: TRESK background K(+) channel is inhibited by phosphorylation via two distinct pathways
source: J Biol Chem 285:14549-57
year: 2010

SequenceSite11980
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite11981
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite11989
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11988
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11987
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11986
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11985
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11984
type: SequenceSite
position status: EQUAL
sequence position: 529

http://identifiers.org/pubmed/8723348
type: PublicationXref
id: 8723348
author: Jefferson, AB
author: Pot, DA
author: Deuter-Reinhard, M
author: Masiarz, FR
author: Cousens, LS
author: Williams, LT
author: Chin, SM
author: Norris, FA
author: Kavanaugh, WM
author: Majerus, PW
db: Pubmed
title: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
source: Curr Biol 6:438-45
year: 1996

SequenceSite11983
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite11982
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite11990
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11991
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11992
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11998
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11997
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11999
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11994
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11993
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11996
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11995
type: SequenceSite
position status: EQUAL
sequence position: 22

coenzyme A
type: SmallMolecule
entity reference: CHEBI:15346
data source: Reactome
xref: UnificationXref1170
xref: UnificationXref1169
cellular location: GO:0005829
comment: Reactome DB_ID: 76194
display name: CoA-SH

Acetyl coenzyme A
type: SmallMolecule
entity reference: CHEBI:15351
data source: Reactome
name: Acetyl-CoA
xref: UnificationXref1166
xref: UnificationXref1167
cellular location: GO:0005829
comment: Reactome DB_ID: 76183
display name: Ac-CoA

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Reactome
xref: UnificationXref1185
xref: UnificationXref1186
cellular location: GO:0060202
comment: Reactome DB_ID: 372511

O-acetylcholine
type: SmallMolecule
entity reference: CHEBI:15355
data source: Reactome
xref: UnificationXref1173
xref: UnificationXref1172
cellular location: GO:0005829
comment: Reactome DB_ID: 264643
display name: AcCho

L-Glutaminic acid
type: SmallMolecule
entity reference: CHEBI:16015
data source: Reactome
name: L-Glutamic acid
name: L-Glutamate
xref: UnificationXref1145
xref: UnificationXref1144
cellular location: GO:0060204
comment: Reactome DB_ID: 210509
display name: Glu

L-Glutaminic acid
type: SmallMolecule
entity reference: CHEBI:16015
data source: Reactome
name: L-Glutamic acid
name: L-Glu
name: L-Glutamate
xref: UnificationXref1093
xref: UnificationXref1092
cellular location: GO:0005759
comment: Reactome DB_ID: 113552
display name: Glu

Choline
type: SmallMolecule
entity reference: SmallMoleculeReference44
data source: Reactome
xref: UnificationXref1160
xref: UnificationXref1159
cellular location: GO:0005829
comment: Reactome DB_ID: 264618
display name: Cho

Choline
type: SmallMolecule
entity reference: SmallMoleculeReference44
data source: Reactome
xref: UnificationXref1157
xref: UnificationXref1158
cellular location: GO:0005576
comment: Reactome DB_ID: 264638
display name: Cho

UnificationXref15910
type: UnificationXref
id: CHEBI:16946
db: ChEBI

UnificationXref15916
type: UnificationXref
id: 4162940
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4162940

UnificationXref15915
type: UnificationXref
id: REACT_26323
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26323.1

UnificationXref15918
type: UnificationXref
id: 4162941
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4162941

UnificationXref15917
type: UnificationXref
id: REACT_138361
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138361.5

UnificationXref15912
type: UnificationXref
id: REACT_4153
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4153.2

UnificationXref15911
type: UnificationXref
id: 29970
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29970

UnificationXref15914
type: UnificationXref
id: 893615
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=893615

UnificationXref15913
type: UnificationXref
id: CHEBI:17442
db: ChEBI

O-acetylcholine
type: SmallMolecule
entity reference: CHEBI:15355
data source: Reactome
xref: UnificationXref1187
xref: UnificationXref1188
cellular location: GO:0060202
comment: Reactome DB_ID: 264788

Pyridoxal 5'-phosphate
type: SmallMolecule
entity reference: CHEBI:18405
data source: Reactome
name: Pyridoxal 5-phosphate
name: Pyridoxal phosphate
xref: UnificationXref1198
xref: UnificationXref1199
cellular location: GO:0005829
comment: Reactome DB_ID: 29390
display name: PXLP

Carbon dioxide
type: SmallMolecule
entity reference: CHEBI:16526
data source: Reactome
xref: UnificationXref1202
xref: UnificationXref1201
cellular location: GO:0005829
comment: Reactome DB_ID: 113528
display name: CO2

UnificationXref15919
type: UnificationXref
id: 4174979
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4174979

Ethylenesuccinic acid
type: SmallMolecule
entity reference: CHEBI:15741
data source: Reactome
name: Butanedionic acid
name: Succinate
name: Succinic acid
xref: UnificationXref1281
xref: UnificationXref1280
cellular location: GO:0005759
comment: Reactome DB_ID: 113536
display name: SUCCA

DPN
type: SmallMolecule
entity reference: CHEBI:15846
data source: Reactome
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref1278
xref: UnificationXref1277
cellular location: GO:0005759
comment: Reactome DB_ID: 113526
display name: NAD

succinate semialdehyde
type: SmallMolecule
entity reference: CHEBI:16265
data source: Reactome
xref: UnificationXref1267
xref: UnificationXref1266
cellular location: GO:0005759
comment: Reactome DB_ID: 880046
display name: SUCCSA

GABA
type: SmallMolecule
entity reference: CHEBI:16865
data source: Reactome
xref: UnificationXref1264
xref: UnificationXref1263
cellular location: GO:0005759
comment: Reactome DB_ID: 916850

Oxoglutaric acid
type: SmallMolecule
entity reference: CHEBI:30915
data source: Reactome
name: 2-Oxoglutarate
name: alpha-Ketoglutaric acid
name: 2-Ketoglutaric acid
xref: UnificationXref1262
xref: UnificationXref1261
cellular location: GO:0005759
comment: Reactome DB_ID: 113594
display name: 2OG

gamma-aminobutyrate
type: SmallMolecule
entity reference: CHEBI:16865
data source: Reactome
xref: UnificationXref1245
xref: UnificationXref1246
cellular location: GO:0005576
comment: Reactome DB_ID: 352003
display name: GABA

http://identifiers.org/pubmed/8167409
type: PublicationXref
id: 8167409
author: McMahon, Jill A
author: Smolich, Beverly D
author: McMahon, Andrew P
author: Papkoff, Jackie
db: Pubmed
title: Wnt family proteins are secreted and associated with the cell surface
source: Mol. Biol. Cell 4:1267-75
year: 1993

gamma-aminobutyrate
type: SmallMolecule
entity reference: CHEBI:16865
data source: Reactome
xref: UnificationXref1237
xref: UnificationXref1238
cellular location: GO:0061201
comment: Reactome DB_ID: 428571
display name: GABA

UnificationXref15920
type: UnificationXref
id: REACT_129510
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129510.5

UnificationXref15921
type: UnificationXref
id: CHEBI:17709
db: ChEBI

UnificationXref15929
type: UnificationXref
id: 4150027
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150027

UnificationXref15928
type: UnificationXref
id: Q8IQV1
db: UniProt

UnificationXref15927
type: UnificationXref
id: 4150025
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150025

UnificationXref15926
type: UnificationXref
id: C9QP52
db: UniProt

UnificationXref15925
type: UnificationXref
id: 4150023
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4150023

UnificationXref15924
type: UnificationXref
id: Q9VW48
db: UniProt

UnificationXref15923
type: UnificationXref
id: REACT_7820
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7820.2

http://identifiers.org/pubmed/8411712
type: PublicationXref
id: 8411712
author: Kamijo, K
author: Osumi, T
author: Hashimoto, T
db: Pubmed
title: PMP70, the 70-kDa peroxisomal membrane protein: a member of the ATP-binding cassette transporters
source: Nippon Rinsho 51:2343-52
year: 1993

UnificationXref15922
type: UnificationXref
id: 174370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174370

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Reactome
xref: UnificationXref1298
xref: UnificationXref1299
cellular location: GO:0005759
comment: Reactome DB_ID: 113529

5-Hydroxyindole acetic acid
type: SmallMolecule
entity reference: CHEBI:27823
data source: Reactome
xref: UnificationXref1302
xref: UnificationXref1301
cellular location: GO:0005759
comment: Reactome DB_ID: 380593
display name: HIAA

NADH
type: SmallMolecule
entity reference: CHEBI:16908
data source: Reactome
xref: UnificationXref1283
xref: UnificationXref1284
cellular location: GO:0005759
comment: Reactome DB_ID: 29362

5-hydroxyindole acetaldehyde
type: SmallMolecule
entity reference: CHEBI:50157
data source: Reactome
xref: UnificationXref1296
xref: UnificationXref1297
cellular location: GO:0005759
comment: Reactome DB_ID: 380598
display name: HIALD

http://identifiers.org/pubmed/17047224
type: PublicationXref
id: 17047224
author: Karin, M
author: Hacker, H
db: Pubmed
title: Regulation and function of IKK and IKK-related kinases
source: Sci STKE 2006:re13
year: 2006

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15996
data source: Reactome
xref: UnificationXref583
xref: UnificationXref584
cellular location: GO:0005829
comment: Reactome DB_ID: 29438
display name: GTP

Dopamine
type: SmallMolecule
entity reference: CHEBI:18243
data source: Reactome
xref: UnificationXref1016
xref: UnificationXref1017
cellular location: GO:0070082
comment: Reactome DB_ID: 351601
display name: DA

Dopamine
type: SmallMolecule
entity reference: CHEBI:18243
data source: Reactome
xref: UnificationXref1014
xref: UnificationXref1013
cellular location: GO:0005829
comment: Reactome DB_ID: 159362
display name: DA

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:16761
data source: Reactome
xref: UnificationXref602
xref: UnificationXref603
cellular location: GO:0005829
comment: Reactome DB_ID: 29370
display name: ADP

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15422
data source: Reactome
xref: UnificationXref600
xref: UnificationXref599
cellular location: GO:0005829
comment: Reactome DB_ID: 113592
display name: ATP

3-(2-Aminoethyl)-1H-indol-5-ol
type: SmallMolecule
entity reference: CHEBI:28790
data source: Reactome
name: 5-Hydroxytryptamine
name: Enteramine
name: Serotonin
xref: UnificationXref1080
xref: UnificationXref1079
cellular location: GO:0005829
comment: Reactome DB_ID: 209914
display name: 5HT

Norepinephrine
type: SmallMolecule
entity reference: CHEBI:18357
data source: Reactome
name: Noradrenaline
xref: UnificationXref1070
xref: UnificationXref1069
cellular location: GO:0005829
comment: Reactome DB_ID: 209789
display name: NAd

Norepinephrine
type: SmallMolecule
entity reference: CHEBI:18357
data source: Reactome
name: Noradrenaline
xref: UnificationXref1068
xref: UnificationXref1067
cellular location: GO:0005576
comment: Reactome DB_ID: 374935
display name: NAd

Norepinephrine
type: SmallMolecule
entity reference: CHEBI:18357
data source: Reactome
name: Noradrenaline
xref: UnificationXref1049
xref: UnificationXref1048
cellular location: GO:0060204
comment: Reactome DB_ID: 372509
display name: NAd

5-Hydroxytryptamine
type: SmallMolecule
entity reference: CHEBI:28790
data source: Reactome
name: 3-(2-Aminoethyl)-1H-indol-5-ol
name: Enteramine
name: Serotonin
xref: UnificationXref1081
xref: UnificationXref1082
cellular location: GO:0070082
comment: Reactome DB_ID: 380585
display name: 5HT

UnificationXref15903
type: UnificationXref
id: 4142081
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4142081

UnificationXref15902
type: UnificationXref
id: 4142080
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4142080

UnificationXref15901
type: UnificationXref
id: Q6NPB9
db: UniProt

UnificationXref15900
type: UnificationXref
id: 4142079
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4142079

UnificationXref15907
type: UnificationXref
id: CHEBI:32816
db: ChEBI

UnificationXref15906
type: UnificationXref
id: REACT_129401
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129401.5

UnificationXref15905
type: UnificationXref
id: 4172561
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172561

UnificationXref15904
type: UnificationXref
id: 4142086
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4142086

UnificationXref15909
type: UnificationXref
id: REACT_3219
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3219.2

UnificationXref15908
type: UnificationXref
id: 29398
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29398

L-Glutamine
type: SmallMolecule
entity reference: CHEBI:18050
data source: Reactome
name: L-2-Aminoglutaramic acid
xref: UnificationXref1088
xref: UnificationXref1087
cellular location: GO:0005759
comment: Reactome DB_ID: 113522
display name: L-Gln

NH4+
type: SmallMolecule
entity reference: CHEBI:28938
data source: Reactome
xref: UnificationXref1091
xref: UnificationXref1090
cellular location: GO:0005759
comment: Reactome DB_ID: 113561

ABL-1
type: ProteinReference
name: Dash
name: Abl
name: CG4032
name: UniProt:P00522 Abl
xref: UnificationXref13314
comment: FUNCTION Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways.CATALYTIC ACTIVITY ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.TISSUE SPECIFICITY Arm and ena colocalize with Abl at adherens junctions throughout development.DEVELOPMENTAL STAGE Expressed both maternally and zygotically.DISRUPTION PHENOTYPE Both loss- and gain-of-function mutants exhibit neurons within the pCC/MP2 pathway that incorrectly project across the midline. Loss of Abl disrupts cell migration and cell shape changes during dorsal closure.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.SIMILARITY Contains 1 protein kinase domain.SIMILARITY Contains 1 SH2 domain.SIMILARITY Contains 1 SH3 domain.
organism: BioSource1

Neurotransmitter Release Cycle
type: Pathway
data source: Reactome
pathway component: REACT 91078.9
pathway component: REACT 101658.9
pathway component: REACT 107033.9
pathway component: REACT 115505.8
pathway component: REACT 110783.9
pathway component: REACT 126429.5
evidence: Evidence79
xref: RelationshipXref65
xref: UnificationXref1294
xref: UnificationXref1293
pathway order: PathwayStep50
pathway order: PathwayStep52
pathway order: PathwayStep56
pathway order: PathwayStep62
pathway order: PathwayStep57
pathway order: PathwayStep73
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Reactome
type: Provenance
comment: http://www.reactome.org

http://identifiers.org/pubmed/16884718
type: PublicationXref
id: 16884718
author: Beyaert, R
author: Janssens, S
author: Schauvliege, R
db: Pubmed
title: Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases
source: FEBS Lett 580:4697-702
year: 2006

http://identifiers.org/pubmed/15901826
type: PublicationXref
id: 15901826
author: Hemler, ME
author: Xu, D
db: Pubmed
title: Metabolic activation-related CD147-CD98 complex
source: Mol Cell Proteomics 4:1061-71
year: 2005

Synthesis of PG
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction1584
pathway component: BiochemicalReaction1582
pathway component: BiochemicalReaction1585
pathway component: BiochemicalReaction1583
evidence: Evidence2359
xref: UnificationXref23186
xref: UnificationXref23187
xref: RelationshipXref1337
pathway order: PathwayStep2353
pathway order: PathwayStep2352
pathway order: PathwayStep2351
pathway order: PathwayStep2350
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11389445
type: PublicationXref
id: 11389445
author: Lasko, PF
author: Lachance, PE
author: Sonenberg, N
author: Verdú, J
author: Birnbaum, MJ
author: Miron, M
db: Pubmed
title: The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila.
source: Nat Cell Biol 3:596-601
year: 2001

http://identifiers.org/pubmed/6323448
type: PublicationXref
id: 6323448
author: Cline, A
author: Moulton, AD
author: Nienhuis, AW
author: Chen, MJ
author: Humphries, RK
author: Shimada, T
author: Maizel, J
db: Pubmed
title: The functional human dihydrofolate reductase gene
source: J Biol Chem 259:3933-43
year: 1984

http://identifiers.org/pubmed/11389444
type: PublicationXref
id: 11389444
author: Wrana, JL
author: Causing, CG
author: Kavsak, P
author: Luo, K
author: Bonni, S
author: Stroschein, SL
author: Wang, HR
db: Pubmed
title: TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation
source: Nat Cell Biol 3:587-95
year: 2001

UniProt:Q9GRX1
type: ProteinReference
xref: UnificationXref6194
organism: BioSource1

UnificationXref15781
type: UnificationXref
id: 4170913
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170913

UnificationXref15780
type: UnificationXref
id: REACT_133769
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133769.5

UnificationXref15789
type: UnificationXref
id: REACT_128303
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128303.5

UnificationXref15788
type: UnificationXref
id: 4175885
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175885

UnificationXref15787
type: UnificationXref
id: REACT_147413
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147413.5

UnificationXref15786
type: UnificationXref
id: 4172250
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172250

UnificationXref15785
type: UnificationXref
id: 4170917
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170917

UnificationXref15784
type: UnificationXref
id: 4170916
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170916

UnificationXref15783
type: UnificationXref
id: 4170915
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170915

UnificationXref15782
type: UnificationXref
id: 4170914
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170914

UnificationXref15770
type: UnificationXref
id: 4170964
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170964

UnificationXref15776
type: UnificationXref
id: REACT_143706
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143706.5

UnificationXref15775
type: UnificationXref
id: 4175876
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175876

UnificationXref15778
type: UnificationXref
id: 4172247
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172247

UnificationXref15777
type: UnificationXref
id: 4172246
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172246

UnificationXref15772
type: UnificationXref
id: 4170966
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170966

UnificationXref15771
type: UnificationXref
id: 4170965
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170965

UnificationXref15774
type: UnificationXref
id: REACT_145182
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145182.5

UnificationXref15773
type: UnificationXref
id: 4171242
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4171242

UnificationXref15779
type: UnificationXref
id: 4172248
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172248

http://identifiers.org/pubmed/9566739
type: PublicationXref
id: 9566739
author: Nicoll, R
author: Zhu, X
author: McManus, ME
author: Brix, LA
db: Pubmed
title: Structural and functional characterisation of human sulfotransferases
source: Chem Biol Interact 109:123-7
year: 1998

UnificationXref15790
type: UnificationXref
id: 4172429
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172429

UnificationXref15792
type: UnificationXref
id: 2077524
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2077524

UniProt:Q9BK28
type: ProteinReference
xref: UnificationXref13686
organism: BioSource1

UnificationXref15791
type: UnificationXref
id: CHEBI:63450
db: ChEBI

UnificationXref15794
type: UnificationXref
id: 2077416
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2077416

UnificationXref15793
type: UnificationXref
id: REACT_121799
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121799.1

UnificationXref15796
type: UnificationXref
id: 4172430
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172430

UnificationXref15795
type: UnificationXref
id: REACT_121428
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121428.1

UnificationXref15798
type: UnificationXref
id: REACT_130340
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130340.5

UnificationXref15797
type: UnificationXref
id: 4172431
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172431

UnificationXref15799
type: UnificationXref
id: 4175877
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175877

sli
type: ProteinReference
name: UniProt:P24014 sli
name: CG8355
xref: UnificationXref13137
comment: FUNCTION A short-range repellent, controlling axon crossing of the midline and a long-range chemorepellent, controlling mesoderm migration and patterning away from the midline. May interact with extracellular matrix molecules. Repulsive ligand for the guidance receptor roundabout (robo) and prevents inappropriate midline crossing by Robo-expressing axons.SUBUNIT Interacts with robo.TISSUE SPECIFICITY In embryos, highest expression occurs around the midline glia and low expression is observed around CNS axons lateral to the midline. Expression can be seen on the commissural axons traversing the glial cells but it is absent from the cell bodies of these neurons.MISCELLANEOUS Flies lacking sli exhibit disruption of the developing midline cells and the commissural axon pathways.SIMILARITY Contains 1 CTCK (C-terminal cystine knot-like) domain.SIMILARITY Contains 7 EGF-like domains.SIMILARITY Contains 1 laminin G-like domain.SIMILARITY Contains 19 LRR (leucine-rich) repeats.SIMILARITY Contains 4 LRRCT domains.SIMILARITY Contains 4 LRRNT domains.
organism: BioSource1

http://identifiers.org/pubmed/15621726
type: PublicationXref
id: 15621726
author: Chen, D
author: Mundy, GR
author: Zhao, M
db: Pubmed
title: Bone morphogenetic proteins
source: Growth Factors 22:233-41
year: 2004

UniProt:Q9GS19
type: ProteinReference
xref: UnificationXref13828
organism: BioSource1

UnificationXref15814
type: UnificationXref
id: 4172258
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172258

UnificationXref15815
type: UnificationXref
id: 4172259
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172259

UnificationXref15812
type: UnificationXref
id: REACT_137874
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137874.5

UnificationXref15813
type: UnificationXref
id: 4172257
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172257

UnificationXref15818
type: UnificationXref
id: 4172263
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172263

UnificationXref15819
type: UnificationXref
id: 4172268
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172268

UnificationXref15816
type: UnificationXref
id: 4172261
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172261

UnificationXref15817
type: UnificationXref
id: 4172262
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172262

UnificationXref15811
type: UnificationXref
id: 4171275
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4171275

UnificationXref15810
type: UnificationXref
id: 4170985
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170985

UnificationXref15823
type: UnificationXref
id: 4172269
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172269

UnificationXref15824
type: UnificationXref
id: REACT_126681
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126681.5

UnificationXref15825
type: UnificationXref
id: 4170968
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170968

UnificationXref15826
type: UnificationXref
id: 4170970
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170970

UnificationXref15827
type: UnificationXref
id: 4170971
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170971

UnificationXref15828
type: UnificationXref
id: 4170972
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170972

UnificationXref15829
type: UnificationXref
id: 4170974
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170974

UnificationXref15820
type: UnificationXref
id: 4172260
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172260

UnificationXref15822
type: UnificationXref
id: 4172265
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172265

UnificationXref15821
type: UnificationXref
id: 4172264
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172264

UnificationXref15838
type: UnificationXref
id: REACT_137800
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137800.5

UnificationXref15839
type: UnificationXref
id: 4175878
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175878

UnificationXref15836
type: UnificationXref
id: 4172314
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172314

UnificationXref15837
type: UnificationXref
id: 4172315
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172315

UnificationXref15834
type: UnificationXref
id: 4172267
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172267

UnificationXref15835
type: UnificationXref
id: REACT_128911
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128911.5

http://identifiers.org/pubmed/15720390
type: PublicationXref
id: 15720390
author: Fabre, AL
author: Orlean, P
author: Taron, CH
db: Pubmed
title: Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly
source: FEBS J 272:1160-8
year: 2005

UnificationXref15833
type: UnificationXref
id: 4170979
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170979

UnificationXref15832
type: UnificationXref
id: 4170978
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170978

UnificationXref15831
type: UnificationXref
id: 4170977
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170977

UnificationXref15830
type: UnificationXref
id: 4170976
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170976

UnificationXref15849
type: UnificationXref
id: 4167880
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4167880

UnificationXref15845
type: UnificationXref
id: 4170989
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170989

UnificationXref15846
type: UnificationXref
id: 4170991
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170991

UnificationXref15847
type: UnificationXref
id: REACT_147329
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147329.5

http://identifiers.org/pubmed/9199292
type: PublicationXref
id: 9199292
author: Dynlacht, BD
author: Sánchez, I
author: Woo, MS
db: Pubmed
title: p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity
source: Mol Cell Biol 17:3566-79
year: 1997

UnificationXref15848
type: UnificationXref
id: 4146711
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4146711

UnificationXref15842
type: UnificationXref
id: 4170987
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170987

UnificationXref15841
type: UnificationXref
id: 4170986
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170986

UnificationXref15844
type: UnificationXref
id: REACT_142323
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142323.5

UnificationXref15843
type: UnificationXref
id: 4170988
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170988

UnificationXref15840
type: UnificationXref
id: REACT_134207
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134207.5

UnificationXref15859
type: UnificationXref
id: REACT_155843
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155843.3

UnificationXref15858
type: UnificationXref
id: 4172427
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172427

UnificationXref15857
type: UnificationXref
id: 4172425
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172425

UnificationXref15856
type: UnificationXref
id: REACT_152805
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152805.3

UnificationXref15850
type: UnificationXref
id: 4170992
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170992

UnificationXref15851
type: UnificationXref
id: 4170993
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170993

UnificationXref15854
type: UnificationXref
id: 4172423
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172423

UnificationXref15855
type: UnificationXref
id: 4172424
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172424

UnificationXref15852
type: UnificationXref
id: 4170995
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170995

UnificationXref15853
type: UnificationXref
id: REACT_127605
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127605.5

UniProt:Q9BKJ2
type: ProteinReference
xref: UnificationXref23307
organism: BioSource1

UnificationXref15868
type: UnificationXref
id: REACT_2495
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2495.2

UnificationXref15867
type: UnificationXref
id: 29870
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29870

UnificationXref15869
type: UnificationXref
id: CHEBI:15374
db: ChEBI

UnificationXref15860
type: UnificationXref
id: 4172428
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172428

UnificationXref15861
type: UnificationXref
id: REACT_152843
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152843.3

UnificationXref15862
type: UnificationXref
id: 4175858
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175858

UnificationXref15863
type: UnificationXref
id: REACT_132703
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132703.5

UnificationXref15864
type: UnificationXref
id: 4175146
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175146

UnificationXref15865
type: UnificationXref
id: REACT_128167
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128167.5

UnificationXref15866
type: UnificationXref
id: CHEBI:15372
db: ChEBI

http://identifiers.org/pubmed/15274632
type: PublicationXref
id: 15274632
author: Strub, JM
author: Selkoe, DJ
author: Ostaszewski, BL
author: Dolios, G
author: Ye, W
author: Wang, R
author: Fraering, PC
author: Wolfe, MS
author: LaVoie, MJ
author: van, Dorsselaer A
db: Pubmed
title: Purification and characterization of the human gamma-secretase complex
source: Biochemistry 43:9774-89
year: 2004

UnificationXref15879
type: UnificationXref
id: CHEBI:30744
db: ChEBI

UnificationXref15878
type: UnificationXref
id: 4142644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4142644

UnificationXref15876
type: UnificationXref
id: REACT_33652
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33652.10

UnificationXref15877
type: UnificationXref
id: 4142646
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4142646

UnificationXref15874
type: UnificationXref
id: 4142641
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4142641

UnificationXref15875
type: UnificationXref
id: 4142645
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4142645

UnificationXref15872
type: UnificationXref
id: P17276
db: UniProt

UnificationXref15873
type: UnificationXref
id: 4142640
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4142640

UnificationXref15870
type: UnificationXref
id: 71112
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71112

UnificationXref15871
type: UnificationXref
id: REACT_5605
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5605.1

http://identifiers.org/pubmed/15274622
type: PublicationXref
id: 15274622
author: Kim, JJ
author: Wang, M
author: Fu, Z
author: Paschke, R
author: Frerman, FE
author: Rao, KS
db: Pubmed
title: Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions
source: Biochemistry 43:9674-84
year: 2004

UnificationXref15889
type: UnificationXref
id: 4162934
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4162934

UnificationXref15885
type: UnificationXref
id: Q8SXC2
db: UniProt

UnificationXref15886
type: UnificationXref
id: MOD:00128
db: MOD

UnificationXref15887
type: UnificationXref
id: 4162931
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4162931

UnificationXref15888
type: UnificationXref
id: Q8IGP9
db: UniProt

UnificationXref15881
type: UnificationXref
id: REACT_5376
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5376.2

UnificationXref15882
type: UnificationXref
id: CHEBI:18005
db: ChEBI

UnificationXref15883
type: UnificationXref
id: 2160487
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2160487

UnificationXref15884
type: UnificationXref
id: REACT_124243
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124243.1

UnificationXref15880
type: UnificationXref
id: 76213
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76213

http://identifiers.org/pubmed/15274629
type: PublicationXref
id: 15274629
author: Takeuchi, N
author: Heck, A
author: Spencer, AC
author: Watanabe, K
author: Spremulli, LL
db: Pubmed
title: Characterization of the human mitochondrial methionyl-tRNA synthetase
source: Biochemistry 43:9743-54
year: 2004

UniProt:Q9BKE5
type: ProteinReference
xref: UnificationXref13744
organism: BioSource1

http://identifiers.org/pubmed/9548721
type: PublicationXref
id: 9548721
author: Funakoshi, T
author: Terada, S
author: Harada, A
author: Hirokawa, N
author: Yonekawa, Y
author: Takei, Y
author: Kanai, Y
author: Noda, T
author: Okada, Y
db: Pubmed
title: Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice
source: J Cell Biol 141:431-41
year: 1998

UniProt:Q9BKE4
type: ProteinReference
xref: UnificationXref13742
organism: BioSource1

http://identifiers.org/pubmed/8128219
type: PublicationXref
id: 8128219
author: Tonks, N K
author: Flint, A J
author: Barford, D
db: Pubmed
title: Crystal structure of human protein tyrosine phosphatase 1B
source: Science 263:1397-404
year: 1994

UniProt:Q9GSE0
type: ProteinReference
xref: UnificationXref507
organism: BioSource1

SHC1 events in ERBB2 signaling
type: Pathway
data source: Reactome
pathway component: REACT 85806.9
pathway component: BiochemicalReaction595
evidence: Evidence934
xref: UnificationXref9869
xref: UnificationXref9868
pathway order: PathwayStep930
pathway order: PathwayStep742
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10681399
type: PublicationXref
id: 10681399
author: Harris, RC
author: Capdevila, JH
author: Falck, JR
db: Pubmed
title: Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase
source: J Lipid Res 41:163-81
year: 2000

http://identifiers.org/pubmed/12515382
type: PublicationXref
id: 12515382
author: Arndt-Jovin, DJ
author: Ingelfinger, D
author: Achsel, T
author: Lührmann, R
db: Pubmed
title: The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci
source: RNA 8:1489-501
year: 2002

http://identifiers.org/pubmed/7060561
type: PublicationXref
id: 7060561
author: Dutilh, CE
author: Dijkman, R
author: De Haas, GH
author: Figarella, C
author: van der Ouderaa, F
author: Grataroli, R
db: Pubmed
title: Studies on prophospholipase A2 and its enzyme from human pancreatic juice. Catalytic properties and sequence of the N-terminal region
source: Eur J Biochem 122:111-7
year: 1982

UnificationXref15800
type: UnificationXref
id: REACT_135977
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135977.5

UnificationXref15809
type: UnificationXref
id: 4170984
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170984

UnificationXref15808
type: UnificationXref
id: 4170983
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170983

UnificationXref15807
type: UnificationXref
id: 4170981
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170981

UnificationXref15806
type: UnificationXref
id: REACT_134741
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134741.5

UnificationXref15805
type: UnificationXref
id: 4171273
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4171273

UnificationXref15804
type: UnificationXref
id: 4171272
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4171272

UnificationXref15803
type: UnificationXref
id: 4171271
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4171271

UnificationXref15802
type: UnificationXref
id: 4171270
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4171270

UnificationXref15801
type: UnificationXref
id: 4171269
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4171269

UniProt:Q9GSZ3
type: ProteinReference
xref: UnificationXref17677
organism: BioSource1

UnificationXref23806
type: UnificationXref
id: D5A7L0
db: UniProt

UnificationXref23807
type: UnificationXref
id: 4154808
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154808

UnificationXref23808
type: UnificationXref
id: A8JV25
db: UniProt

UnificationXref23809
type: UnificationXref
id: 4154809
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154809

UnificationXref23802
type: UnificationXref
id: Q9VYR2
db: UniProt

UnificationXref23803
type: UnificationXref
id: 4154806
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154806

UnificationXref23804
type: UnificationXref
id: E8NH33
db: UniProt

UnificationXref23805
type: UnificationXref
id: 4154807
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154807

UnificationXref23800
type: UnificationXref
id: Q9VXA5
db: UniProt

UnificationXref23801
type: UnificationXref
id: 4154805
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154805

UnificationXref23819
type: UnificationXref
id: 4154814
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154814

UnificationXref23817
type: UnificationXref
id: 4154813
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154813

UnificationXref23818
type: UnificationXref
id: Q9VWT3
db: UniProt

UnificationXref23811
type: UnificationXref
id: 4154810
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154810

UnificationXref23812
type: UnificationXref
id: Q7KUX2
db: UniProt

UnificationXref23810
type: UnificationXref
id: Q8T0R6
db: UniProt

UnificationXref23815
type: UnificationXref
id: 4154812
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154812

UnificationXref23816
type: UnificationXref
id: Q9XZS5
db: UniProt

UnificationXref23813
type: UnificationXref
id: 4154811
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154811

UnificationXref23814
type: UnificationXref
id: B8A431
db: UniProt

http://identifiers.org/pubmed/2040271
type: PublicationXref
id: 2040271
author: Sadahiro, S
author: Matsuda, T
author: Takenaka, M
author: Tanaka, T
author: Noguchi, T
author: Hirai, H
author: Imai, E
author: Yamada, K
db: Pubmed
title: Isolation and characterization of the human pyruvate kinase M gene
source: Eur J Biochem 198:101-6
year: 1991

UnificationXref23828
type: UnificationXref
id: 4154791
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154791

UnificationXref23829
type: UnificationXref
id: 4154793
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154793

UnificationXref23820
type: UnificationXref
id: A8JV19
db: UniProt

UnificationXref23821
type: UnificationXref
id: 4154815
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154815

UnificationXref23822
type: UnificationXref
id: 4154816
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154816

UnificationXref23823
type: UnificationXref
id: 4154777
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154777

UnificationXref23824
type: UnificationXref
id: 4154781
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154781

UnificationXref23825
type: UnificationXref
id: 4154783
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154783

UnificationXref23826
type: UnificationXref
id: 4154787
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154787

UnificationXref23827
type: UnificationXref
id: 4154789
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154789

Di-peptides/tri-peptides
type: Complex
data source: Reactome
member physical entity: Di-peptides
member physical entity: Tri-peptides
xref: UnificationXref195
xref: UnificationXref196
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 428026

Tri-peptides
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry8
component: SmallMolecule23
xref: UnificationXref150
xref: UnificationXref149
cellular location: GO:0005576
comment: Reactome DB_ID: 427999

Tri-peptides
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry10
component: SmallMolecule42
xref: UnificationXref194
xref: UnificationXref193
cellular location: GO:0005829
comment: Reactome DB_ID: 428046

Di-peptides
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry9
component: SmallMolecule42
xref: UnificationXref192
xref: UnificationXref191
cellular location: GO:0005829
comment: Reactome DB_ID: 427981

SLC7A5:SLC3A2 heterodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry11
component stoichiometry: Stoichiometry12
component: Protein59
component: Protein58
xref: UnificationXref335
cellular location: GO:0005886
comment: Reactome DB_ID: 4155140

Factors involved in megakaryocyte development and platelet production
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction1164
pathway component: BiochemicalReaction1168
pathway component: BiochemicalReaction1175
pathway component: REACT 141932.5
pathway component: BiochemicalReaction1177
pathway component: BiochemicalReaction1165
pathway component: BiochemicalReaction1176
pathway component: BiochemicalReaction1174
pathway component: BiochemicalReaction1173
pathway component: BiochemicalReaction1172
pathway component: BiochemicalReaction1166
pathway component: BiochemicalReaction1178
pathway component: BiochemicalReaction1170
pathway component: BiochemicalReaction1171
pathway component: BiochemicalReaction1167
pathway component: BiochemicalReaction1169
evidence: Evidence1825
xref: UnificationXref18465
xref: UnificationXref18464
pathway order: PathwayStep1805
pathway order: PathwayStep1799
pathway order: PathwayStep1794
pathway order: PathwayStep1819
pathway order: PathwayStep1797
pathway order: PathwayStep1803
pathway order: PathwayStep1807
pathway order: PathwayStep1798
pathway order: PathwayStep1793
pathway order: PathwayStep1802
pathway order: PathwayStep1801
pathway order: PathwayStep1804
pathway order: PathwayStep1806
pathway order: PathwayStep1795
pathway order: PathwayStep1800
pathway order: PathwayStep1796
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

PKA-mediated phosphorylation of CREB
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction464
pathway component: BiochemicalReaction463
pathway component: BiochemicalReaction462
pathway component: REACT 28407.10
evidence: Evidence719
xref: UnificationXref8066
xref: UnificationXref8067
pathway order: PathwayStep707
pathway order: PathwayStep708
pathway order: PathwayStep705
pathway order: PathwayStep706
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11278283
type: PublicationXref
id: 11278283
author: Tsubuki, S
author: Lee, KK
author: Yajima, N
author: Ohyama, T
author: Yonehara, S
db: Pubmed
title: MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
source: J Biol Chem 276:19276-85
year: 2001

http://identifiers.org/pubmed/22798961
type: PublicationXref
id: 22798961
author: Wang, Xiaohong
author: Li, Ju-Pi
author: Chuang, Huai-Chia
author: Tan, Tse-Hua
db: Pubmed
title: Regulation of PKC-? function by phosphorylation in T cell receptor signaling
source: Front Immunol 3:197
year: 2012

UniProt:P18824 arm
type: ProteinReference
name: CG11579
name: arm
xref: UnificationXref11620
comment: FUNCTION Isoform neural may associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Isoform cytoplasmic accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis.SUBUNIT Interacts with Mer and Moe at the adherens junction.TISSUE SPECIFICITY Isoform cytoplasmic is predominant before germ band retraction, after retraction and, during larval stages, it is found in high levels in specific cells along the CNS midline. Isoform neural is first seen after germ band retraction in the axon tracts of the CNS, also present in axons during larval stages and accumulates in the motor neurons of the segmental and intersegmental nerves as they exit the CNS. Both isoforms accumulate in the PNS.DEVELOPMENTAL STAGE Present at all stages, but reached the highest levels during early to mid-embryogenesis.PTM Phosphorylated on Ser, Thr and Tyr residues. Level of phosphorylation varies both during embryonic development and from embryonic tissue to tissue. Sgg is required for phosphorylation and wg signal negatively regulates arm phosphorylation. Hypophosphorylated form of arm increases in steady-state levels.SIMILARITY Belongs to the beta-catenin family.SIMILARITY Contains 13 ARM repeats.
organism: BioSource1

http://identifiers.org/pubmed/19416660
type: PublicationXref
id: 19416660
author: Ren, M
author: Xu, Y
author: Malhotra, A
author: Schlame, M
db: Pubmed
title: Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species
source: Biochim Biophys Acta 1791:314-20
year: 2009

http://identifiers.org/pubmed/17597991
type: PublicationXref
id: 17597991
author: Ruggeri, ZM
db: Pubmed
title: Von Willebrand factor: looking back and looking forward
source: Thromb Haemost 98:55-62
year: 2007

UniProt:Q9GSR2
type: ProteinReference
xref: UnificationXref14371
organism: BioSource1

http://identifiers.org/pubmed/11278251
type: PublicationXref
id: 11278251
author: Murakami, G
author: Imamura, T
author: Tanaka, K
author: Fukuchi, M
author: Ebisawa, T
author: Miyazono, K
author: Chiba, T
db: Pubmed
title: Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
source: J Biol Chem 276:12477-80
year: 2001

UniProt:Q9GSR1
type: ProteinReference
xref: UnificationXref14375
organism: BioSource1

http://identifiers.org/pubmed/10892742
type: PublicationXref
id: 10892742
author: Kidd, T
author: Bashaw, GJ
author: Murray, D
author: Pawson, T
author: Goodman, CS
db: Pubmed
title: Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor
source: Cell 101:703-15
year: 2000

Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction927
pathway component: BiochemicalReaction926
evidence: Evidence1448
xref: UnificationXref14431
xref: UnificationXref14430
pathway order: PathwayStep1444
pathway order: PathwayStep1443
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/19487573
type: PublicationXref
id: 19487573
author: Agami, Reuven
author: Rouhanifard, Sara H
author: Holland, Eric C
author: Tuschl, Thomas
author: Huse, Jason T
author: Hambardzumyan, Dolores
author: Brennan, Cameron
author: Sohn-Lee, Cherin
author: le Sage, Carlos
author: Wee, Boyoung
author: Pena, John
db: Pubmed
title: The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
source: Genes Dev. 23:1327-37
year: 2009

http://identifiers.org/pubmed/9188692
type: PublicationXref
id: 9188692
author: Gill, GN
author: Kurten, RC
author: Cadena, DL
db: Pubmed
title: The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis
source: Biochemistry 36:6960-7
year: 1997

UniProt:Q9GT67
type: ProteinReference
xref: UnificationXref19494
organism: BioSource1

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
type: Pathway
data source: Reactome
pathway component: REACT 131727.5
evidence: Evidence3262
xref: UnificationXref31721
xref: UnificationXref31722
pathway order: PathwayStep3249
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/7938165
type: PublicationXref
id: 7938165
author: Martin, GR
author: Humphrey, PP
author: Saxena, PR
author: Fozard, JR
author: Mylecharane, EJ
author: Clarke, DE
author: Hartig, PR
author: Hoyer, D
db: Pubmed
title: International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin)
source: Pharmacol Rev 46:157-203
year: 1994

http://identifiers.org/pubmed/7938162
type: PublicationXref
id: 7938162
author: Lefkowitz, RJ
author: Hieble, JP
author: Molinoff, PB
author: Minneman, KP
author: Trendelenburg, U
author: Langer, SZ
author: Bylund, DB
author: Ruffolo RR, Jr
author: Eikenberg, DC
db: Pubmed
title: International Union of Pharmacology nomenclature of adrenoceptors
source: Pharmacol Rev 46:121-36
year: 1994

http://identifiers.org/pubmed/10648173
type: PublicationXref
id: 10648173
author: Menear, K
author: Baldock, D
author: Graff, P
author: Jones, CE
author: Akhlaq, M
author: Graham, B
db: Pubmed
title: Purification and characterization of human Syk produced using a baculovirus expression system
source: Protein Expr Purif 18:86-94
year: 2000

http://identifiers.org/pubmed/19261456
type: PublicationXref
id: 19261456
author: Procko, E
author: Gaudet, R
db: Pubmed
title: Antigen processing and presentation: TAPping into ABC transporters
source: Curr Opin Immunol 21:84-91
year: 2009

http://identifiers.org/pubmed/8244992
type: PublicationXref
id: 8244992
author: Gerriets, JE
author: Curwin, SL
author: Last, JA
db: Pubmed
title: Tendon hypertrophy is associated with increased hydroxylation of nonhelical lysine residues at two specific cross-linking sites in type I collagen
source: J Biol Chem 268:25553-60
year: 1993

http://identifiers.org/pubmed/16571669
type: PublicationXref
id: 16571669
author: Perry, RJ
author: Ridgway, ND
db: Pubmed
title: Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein
source: Mol Biol Cell 17:2604-16
year: 2006

http://identifiers.org/pubmed/9694793
type: PublicationXref
id: 9694793
author: Kadesch, T
author: Downes, M
author: Kao, HY
author: Evans, RM
author: Ordentlich, P
author: Kintner, CR
author: Tang, Z
author: Koyano-Nakagawa, N
db: Pubmed
title: A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
source: Genes Dev 12:2269-77
year: 1998

http://identifiers.org/pubmed/18215067
type: PublicationXref
id: 18215067
author: Holmes, RP
author: Murray, MS
author: Lowther, WT
db: Pubmed
title: Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design
source: Biochemistry 47:2439-49
year: 2008

http://identifiers.org/pubmed/7925341
type: PublicationXref
id: 7925341
author: Bandoh, S
author: Takeda, O
author: Takahashi, E
author: Tanabe, T
author: Ihara, H
author: Miyata, A
author: Yokoyama, C
db: Pubmed
title: Characterization of the human gene (TBXAS1) encoding thromboxane synthase
source: Eur J Biochem 224:273-9
year: 1994

Unblocking of NMDA receptor, glutamate binding and activation
type: Pathway
data source: Reactome
pathway component: Membrane depolarization upon activation of Ca impermeable AMPA receptors
evidence: Evidence100
xref: UnificationXref1530
xref: UnificationXref1531
pathway order: PathwayStep94
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/13679574
type: PublicationXref
id: 13679574
author: Bouvier, M
author: Rousseau, G
author: Angers, S
author: Charest, PG
author: Kohout, T
author: Azzi, M
author: Piñeyro, G
db: Pubmed
title: Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
source: Proc Natl Acad Sci U S A 100:11406-11
year: 2003

http://identifiers.org/pubmed/10693756
type: PublicationXref
id: 10693756
author: Ye, J
author: Rawson, RB
db: Pubmed
title: Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans
source: Cell 100:391-8
year: 2000

Role of second messengers in netrin-1 signaling
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction834
evidence: Evidence1290
xref: UnificationXref13189
xref: UnificationXref13188
pathway order: PathwayStep1282
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/9883897
type: PublicationXref
id: 9883897
author: Csere, P
author: Lill, R
author: Kispal, G
db: Pubmed
title: Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p
source: FEBS Lett 441:266-70
year: 1998

http://identifiers.org/pubmed/12147242
type: PublicationXref
id: 12147242
author: Maekawa, M
author: Aoyagi, K
author: Yoshida, T
author: Matsukura, N
author: Tanabe, C
author: Sasaki, H
author: Terada, M
author: Ishizuka, T
author: Tajiri, T
author: Tokunaga, A
author: Sakamoto, H
db: Pubmed
title: Gene amplification profiling of esophageal squamous cell carcinomas by DNA array CGH
source: Biochem Biophys Res Commun 296:152-5
year: 2002

UniProt:Q9GU23
type: ProteinReference
xref: UnificationXref7043
organism: BioSource1

NCAM signaling for neurite out-growth
type: Pathway
data source: Reactome
pathway component: REACT 85806.9
pathway component: BiochemicalReaction590
pathway component: BiochemicalReaction585
pathway component: BiochemicalReaction825
pathway component: BiochemicalReaction824
pathway component: REACT 78438.9
pathway component: BiochemicalReaction823
evidence: Evidence1282
xref: UnificationXref13121
xref: UnificationXref13122
pathway order: PathwayStep1270
pathway order: PathwayStep1268
pathway order: PathwayStep1269
pathway order: PathwayStep910
pathway order: PathwayStep1273
pathway order: PathwayStep742
pathway order: PathwayStep917
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/9883880
type: PublicationXref
id: 9883880
author: Callebaut, I
author: Dehoux, P
author: Cossart, P
db: Pubmed
title: EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family
source: FEBS Lett 441:181-5
year: 1998

http://identifiers.org/pubmed/14530973
type: PublicationXref
id: 14530973
author: Mackenzie, B
author: Hediger, MA
db: Pubmed
title: SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1
source: Pflugers Arch 447:571-9
year: 2004

http://identifiers.org/pubmed/9331217
type: PublicationXref
id: 9331217
author: Cooper, JA
author: Hart, MC
author: Korshunova, YO
db: Pubmed
title: Vertebrates have conserved capping protein alpha isoforms with specific expression patterns
source: Cell Motil Cytoskeleton 38:120-32
year: 1997

UnificationXref23881
type: UnificationXref
id: 4172644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172644

UnificationXref23880
type: UnificationXref
id: 4143088
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4143088

UnificationXref23885
type: UnificationXref
id: REACT_155114
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155114.3

UnificationXref23884
type: UnificationXref
id: 4175896
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175896

UnificationXref23883
type: UnificationXref
id: REACT_154254
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154254.3

UnificationXref23882
type: UnificationXref
id: 4172646
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172646

http://identifiers.org/pubmed/12920597
type: PublicationXref
id: 12920597
author: Hamm, LL
author: Nakhoul, NL
db: Pubmed
title: Non-erythroid Rh glycoproteins: a putative new family of mammalian ammonium transporters
source: Pflugers Arch 447:807-12
year: 2004

UnificationXref23888
type: UnificationXref
id: REACT_151674
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151674.1

UnificationXref23889
type: UnificationXref
id: CHEBI:34144
db: ChEBI

UnificationXref23886
type: UnificationXref
id: CHEBI:34145
db: ChEBI

UnificationXref23887
type: UnificationXref
id: 2142790
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142790

UnificationXref23870
type: UnificationXref
id: REACT_3050
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3050.2

UnificationXref23872
type: UnificationXref
id: 111745
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111745

UnificationXref23871
type: UnificationXref
id: CHEBI:17858
db: ChEBI

UnificationXref23874
type: UnificationXref
id: CHEBI:28209
db: ChEBI

UnificationXref23873
type: UnificationXref
id: REACT_3495
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3495.2

UnificationXref23875
type: UnificationXref
id: 2142733
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142733

UnificationXref23876
type: UnificationXref
id: REACT_151106
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151106.1

UnificationXref23877
type: UnificationXref
id: Q4V6H2
db: UniProt

UnificationXref23878
type: UnificationXref
id: MOD:00031
db: MOD

Integrin cell surface interactions
type: Pathway
data source: Reactome
pathway component: REACT 88698.9
evidence: Evidence1175
xref: UnificationXref12035
xref: UnificationXref12034
pathway order: PathwayStep1172
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref23879
type: UnificationXref
id: 4143087
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4143087

http://identifiers.org/pubmed/14614009
type: PublicationXref
id: 14614009
author: Bartlett, JM
author: Krishna, NS
author: Witton, CJ
author: Edwards, J
db: Pubmed
title: Gene amplifications associated with the development of hormone-resistant prostate cancer
source: Clin Cancer Res 9:5271-81
year: 2003

UnificationXref23894
type: UnificationXref
id: CHEBI:15626
db: ChEBI

UnificationXref23893
type: UnificationXref
id: REACT_153231
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153231.3

UnificationXref23896
type: UnificationXref
id: REACT_151618
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151618.1

UnificationXref23895
type: UnificationXref
id: 2142811
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142811

UnificationXref23890
type: UnificationXref
id: 2142716
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142716

UnificationXref23892
type: UnificationXref
id: 4172647
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172647

UnificationXref23891
type: UnificationXref
id: REACT_152057
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152057.1

UnificationXref23897
type: UnificationXref
id: CHEBI:34146
db: ChEBI

UnificationXref23898
type: UnificationXref
id: 2142678
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142678

UnificationXref23899
type: UnificationXref
id: REACT_150517
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150517.1

http://identifiers.org/pubmed/18547676
type: PublicationXref
id: 18547676
author: Rey, G
author: Kropf, M
author: Kulangara, K
author: Hirling, H
author: Glauser, L
author: Johnsson, K
db: Pubmed
title: Subunit-specific surface mobility of differentially labeled AMPA receptor subunits
source: Eur J Cell Biol 87:763-78
year: 2008

UnificationXref23840
type: UnificationXref
id: REACT_17944
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17944.2

UnificationXref23841
type: UnificationXref
id: Q9VBG1
db: UniProt

UnificationXref23845
type: UnificationXref
id: Q9VPG0
db: UniProt

UnificationXref23844
type: UnificationXref
id: 4154750
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154750

UnificationXref23843
type: UnificationXref
id: Q29R20
db: UniProt

UnificationXref23842
type: UnificationXref
id: 4154746
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154746

UnificationXref23849
type: UnificationXref
id: Q1WWB2
db: UniProt

UnificationXref23848
type: UnificationXref
id: 4154758
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154758

UnificationXref23847
type: UnificationXref
id: Q9VJ94
db: UniProt

UnificationXref23846
type: UnificationXref
id: 4154754
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154754

http://identifiers.org/pubmed/224930
type: PublicationXref
id: 224930
author: Inoue, K
author: Yamasawa, K
author: Nishimukai, H
db: Pubmed
title: Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes.
source: Biochim Biophys Acta 569:117-23
year: 1979

http://identifiers.org/pubmed/18436705
type: PublicationXref
id: 18436705
author: Scheuner, D
author: Kaufman, RJ
db: Pubmed
title: The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes
source: Endocr Rev 29:317-33
year: 2008

UnificationXref23830
type: UnificationXref
id: 4154795
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154795

UnificationXref23832
type: UnificationXref
id: 4154801
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154801

http://identifiers.org/pubmed/8647822
type: PublicationXref
id: 8647822
author: Sanchez, HB
author: Osborne, TF
author: Rosenfeld, JM
author: Vallett, SM
db: Pubmed
title: A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene
source: J Biol Chem 271:12247-53
year: 1996

UnificationXref23831
type: UnificationXref
id: 4154797
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154797

UnificationXref23834
type: UnificationXref
id: 4154804
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154804

UnificationXref23833
type: UnificationXref
id: 4154803
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154803

UnificationXref23836
type: UnificationXref
id: 4154819
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154819

UnificationXref23835
type: UnificationXref
id: 4154817
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154817

UnificationXref23838
type: UnificationXref
id: CHEBI:15650
db: ChEBI

UnificationXref23837
type: UnificationXref
id: REACT_157453
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157453.3

UnificationXref23839
type: UnificationXref
id: 266033
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266033

UnificationXref23862
type: UnificationXref
id: 4154773
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154773

UnificationXref23863
type: UnificationXref
id: REACT_89727
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89727.9

UnificationXref23860
type: UnificationXref
id: 4154770
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154770

UnificationXref23861
type: UnificationXref
id: 4154771
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154771

UnificationXref23869
type: UnificationXref
id: 29450
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29450

UnificationXref23868
type: UnificationXref
id: REACT_15596
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15596.2

UnificationXref23867
type: UnificationXref
id: 266010
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266010

UnificationXref23866
type: UnificationXref
id: CHEBI:15632
db: ChEBI

UnificationXref23865
type: UnificationXref
id: REACT_153955
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153955.3

UnificationXref23864
type: UnificationXref
id: 4175545
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175545

UnificationXref23850
type: UnificationXref
id: 4154760
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154760

UnificationXref23851
type: UnificationXref
id: Q9VJ91
db: UniProt

UnificationXref23852
type: UnificationXref
id: 4154762
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154762

UnificationXref23858
type: UnificationXref
id: 4154768
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154768

UnificationXref23857
type: UnificationXref
id: 4154767
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154767

UnificationXref23859
type: UnificationXref
id: 4154769
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154769

UnificationXref23854
type: UnificationXref
id: 4154764
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154764

UnificationXref23853
type: UnificationXref
id: 4154763
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154763

UnificationXref23856
type: UnificationXref
id: 4154766
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154766

UnificationXref23855
type: UnificationXref
id: 4154765
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154765

UnificationXref23932
type: UnificationXref
id: REACT_153219
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153219.3

UnificationXref23933
type: UnificationXref
id: 4175894
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175894

UnificationXref23930
type: UnificationXref
id: REACT_151442
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151442.1

UnificationXref23931
type: UnificationXref
id: 4172643
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172643

UnificationXref23936
type: UnificationXref
id: 2142739
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142739

UnificationXref23937
type: UnificationXref
id: REACT_150802
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150802.1

UnificationXref23934
type: UnificationXref
id: REACT_156935
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156935.3

UnificationXref23935
type: UnificationXref
id: CHEBI:34450
db: ChEBI

SequenceSite23022
type: SequenceSite
position status: EQUAL
sequence position: 586

SequenceSite23023
type: SequenceSite
position status: EQUAL
sequence position: 232

SequenceSite23024
type: SequenceSite
position status: EQUAL
sequence position: 586

UnificationXref23938
type: UnificationXref
id: 4154528
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154528

SequenceSite23025
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref23939
type: UnificationXref
id: 4154529
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154529

http://identifiers.org/pubmed/11851336
type: PublicationXref
id: 11851336
author: Swain, A
author: Dunten, P
author: Crowther, R
author: Kammlott, U
author: Wertheimer, SJ
author: Michel, H
author: Weber, D
author: Ramsey, GB
author: Levin, W
author: Belunis, C
author: Hollfelder, K
db: Pubmed
title: Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site
source: J Mol Biol 316:257-264
year: 2002

SequenceSite23020
type: SequenceSite
position status: EQUAL
sequence position: 583

SequenceSite23021
type: SequenceSite
position status: EQUAL
sequence position: 232

SequenceSite23027
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23026
type: SequenceSite
position status: EQUAL
sequence position: 231

SequenceSite23029
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23028
type: SequenceSite
position status: EQUAL
sequence position: 231

http://identifiers.org/pubmed/2408761
type: PublicationXref
id: 2408761
author: Sharp, PA
author: Moore, CL
db: Pubmed
title: Accurate cleavage and polyadenylation of exogenous RNA substrate.
source: Cell 41:845-55
year: 1985

UnificationXref23941
type: UnificationXref
id: 4172641
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172641

UnificationXref23942
type: UnificationXref
id: REACT_157952
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157952.3

UnificationXref23943
type: UnificationXref
id: CHEBI:34490
db: ChEBI

UnificationXref23944
type: UnificationXref
id: 2142662
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142662

UnificationXref23945
type: UnificationXref
id: REACT_152366
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152366.1

UnificationXref23946
type: UnificationXref
id: CHEBI:34130
db: ChEBI

UnificationXref23947
type: UnificationXref
id: 2142835
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142835

UnificationXref23948
type: UnificationXref
id: REACT_151653
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151653.1

SequenceSite23035
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref23949
type: UnificationXref
id: CHEBI:34157
db: ChEBI

SequenceSite23036
type: SequenceSite
position status: EQUAL
sequence position: 538

SequenceSite23033
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/22110128
type: PublicationXref
id: 22110128
author: Sharma, Manisha
author: Johnson, Michael
author: Henderson, Beric R
author: Jamieson, Cara
author: Molloy, Mark P
db: Pubmed
title: Specific armadillo repeat sequences facilitate ?-catenin nuclear transport in live cells via direct binding to nucleoporins Nup62, Nup153, and RanBP2/Nup358
source: J. Biol. Chem. 287:819-31
year: 2012

SequenceSite23034
type: SequenceSite
position status: EQUAL
sequence position: 538

SequenceSite23031
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23032
type: SequenceSite
position status: EQUAL
sequence position: 338

SequenceSite23030
type: SequenceSite
position status: EQUAL
sequence position: 338

SequenceSite23039
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23038
type: SequenceSite
position status: EQUAL
sequence position: 538

SequenceSite23037
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref23940
type: UnificationXref
id: 4154530
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154530

UnificationXref23914
type: UnificationXref
id: 140356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=140356

UnificationXref23915
type: UnificationXref
id: REACT_3333
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3333.2

UnificationXref23912
type: UnificationXref
id: 4175893
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175893

UnificationXref23913
type: UnificationXref
id: REACT_154390
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154390.3

UnificationXref23910
type: UnificationXref
id: 4172635
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172635

UnificationXref23911
type: UnificationXref
id: REACT_156046
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156046.3

SequenceSite23000
type: SequenceSite
position status: EQUAL
sequence position: 664

UnificationXref23918
type: UnificationXref
id: CHEBI:63998
db: ChEBI

SequenceSite23001
type: SequenceSite
position status: EQUAL
sequence position: 194

UnificationXref23919
type: UnificationXref
id: 2142836
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142836

SequenceSite23002
type: SequenceSite
position status: EQUAL
sequence position: 293

UnificationXref23916
type: UnificationXref
id: 113601
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113601

SequenceSite23003
type: SequenceSite
position status: EQUAL
sequence position: 194

UnificationXref23917
type: UnificationXref
id: REACT_2882
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2882.1

SequenceSite23005
type: SequenceSite
position status: EQUAL
sequence position: 194

SequenceSite23004
type: SequenceSite
position status: EQUAL
sequence position: 293

SequenceSite23007
type: SequenceSite
position status: EQUAL
sequence position: 194

SequenceSite23006
type: SequenceSite
position status: EQUAL
sequence position: 293

SequenceSite23009
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite23008
type: SequenceSite
position status: EQUAL
sequence position: 293

http://identifiers.org/pubmed/3893466
type: PublicationXref
id: 3893466
author: Jornvall, H
db: Pubmed
title: Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes
source: Alcohol 2:61-6
year: 1985

UnificationXref23923
type: UnificationXref
id: 4154515
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154515

UnificationXref23924
type: UnificationXref
id: 4154516
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154516

UnificationXref23925
type: UnificationXref
id: 4154517
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154517

UniProt:C0PDF0
type: ProteinReference
xref: UnificationXref11231
organism: BioSource1

UnificationXref23926
type: UnificationXref
id: 4172639
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172639

UnificationXref23920
type: UnificationXref
id: REACT_150696
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150696.1

UnificationXref23921
type: UnificationXref
id: 113564
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113564

UniProt:C0PDF4
type: ProteinReference
xref: UnificationXref24625
organism: BioSource1

UnificationXref23922
type: UnificationXref
id: REACT_2334
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2334.1

SequenceSite23010
type: SequenceSite
position status: EQUAL
sequence position: 179

SequenceSite23013
type: SequenceSite
position status: EQUAL
sequence position: 24

UnificationXref23927
type: UnificationXref
id: REACT_154595
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154595.3

SequenceSite23014
type: SequenceSite
position status: EQUAL
sequence position: 179

UnificationXref23928
type: UnificationXref
id: CHEBI:34306
db: ChEBI

SequenceSite23011
type: SequenceSite
position status: EQUAL
sequence position: 24

UnificationXref23929
type: UnificationXref
id: 2142780
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142780

SequenceSite23012
type: SequenceSite
position status: EQUAL
sequence position: 179

SequenceSite23018
type: SequenceSite
position status: EQUAL
sequence position: 583

SequenceSite23017
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite23016
type: SequenceSite
position status: EQUAL
sequence position: 179

SequenceSite23015
type: SequenceSite
position status: EQUAL
sequence position: 24

http://identifiers.org/pubmed/8662720
type: PublicationXref
id: 8662720
author: Korenberg, J
author: Garrow, TA
author: Qi, H
author: Choi, YJ
author: Shane, B
author: Chen, L
db: Pubmed
title: Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
source: J Biol Chem 271:13077-87
year: 1996

SequenceSite23019
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/15585605
type: PublicationXref
id: 15585605
author: Takeda, K
author: Akira, S
db: Pubmed
title: TIRAP/Mal, TRIF and TRAM. Differential utilization of these TIR
source: Int Immunol 17:1-14
year: 2005

UnificationXref23906
type: UnificationXref
id: REACT_152342
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152342.1

UnificationXref23905
type: UnificationXref
id: 2161759
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161759

UnificationXref23908
type: UnificationXref
id: 2142761
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142761

UnificationXref23907
type: UnificationXref
id: CHEBI:63992
db: ChEBI

UnificationXref23909
type: UnificationXref
id: REACT_151064
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151064.1

UnificationXref23900
type: UnificationXref
id: 4172648
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172648

UnificationXref23902
type: UnificationXref
id: 4175897
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175897

UnificationXref23901
type: UnificationXref
id: REACT_152572
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152572.3

UnificationXref23904
type: UnificationXref
id: CHEBI:6498
db: ChEBI

UnificationXref23903
type: UnificationXref
id: REACT_152638
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152638.3

http://identifiers.org/pubmed/15031527
type: PublicationXref
id: 15031527
author: Matsumoto, M
author: Seya, T
author: Funami, K
author: Oshiumi, H
db: Pubmed
title: Toll-like receptor 3: a link between toll-like receptor, interferon and viruses
source: Microbiol Immunol 48:147-54
year: 2004

http://identifiers.org/pubmed/8618861
type: PublicationXref
id: 8618861
author: Nevins, JR
author: DeGregori, J
author: Ohtani, K
db: Pubmed
title: Regulation of the cyclin E gene by transcription factor E2F1
source: Proc Natl Acad Sci U S A 92:12146-50
year: 1995

http://identifiers.org/pubmed/12151385
type: PublicationXref
id: 12151385
author: Shimanuki, T
author: Murakami, G
author: Imamura, T
author: Shikauchi, Y
author: Fukuchi, M
author: Suzuki, C
author: Miyazono, K
db: Pubmed
title: Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane
source: J Biol Chem 277:39919-25
year: 2002

UniProt:Q9GTU9
type: ProteinReference
xref: UnificationXref9321
organism: BioSource1

UniProt:Q9GU68
type: ProteinReference
xref: UnificationXref6137
organism: BioSource1

UniProt:Q9GTU5
type: ProteinReference
xref: UnificationXref13696
organism: BioSource1

SequenceSite23082
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23083
type: SequenceSite
position status: EQUAL
sequence position: 402

SequenceSite23080
type: SequenceSite
position status: EQUAL
sequence position: 402

SequenceSite23081
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite23086
type: SequenceSite
position status: EQUAL
sequence position: 402

SequenceSite23087
type: SequenceSite
position status: EQUAL
sequence position: 213

http://identifiers.org/pubmed/16271386
type: PublicationXref
id: 16271386
author: Tomari, Y
author: Bartel, DP
author: Zamore, Phillip D
author: Shin, C
author: Matranga, C
db: Pubmed
title: Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
source: Cell 123:607-20
year: 2005

SequenceSite23084
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite23085
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23088
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23089
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23090
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23091
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23092
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23093
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23094
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23095
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/21944752
type: PublicationXref
id: 21944752
author: Pierrel, F
author: Lill, R
author: Webert, H
author: Mühlenhoff, U
author: Fontecave, M
author: Ozeir, M
db: Pubmed
title: Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency
source: Chem Biol 18:1134-42
year: 2011

SequenceSite23096
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23097
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite23098
type: SequenceSite
position status: EQUAL
sequence position: 20

SequenceSite23099
type: SequenceSite
position status: EQUAL
sequence position: 55

SequenceSite23069
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite23068
type: SequenceSite
position status: EQUAL
sequence position: 209

SequenceSite23067
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite23066
type: SequenceSite
position status: EQUAL
sequence position: 215

SequenceSite23065
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite23064
type: SequenceSite
position status: EQUAL
sequence position: 194

SequenceSite23063
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite23062
type: SequenceSite
position status: EQUAL
sequence position: 194

SequenceSite23061
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite23060
type: SequenceSite
position status: EQUAL
sequence position: 194

http://identifiers.org/pubmed/10524214
type: PublicationXref
id: 10524214
author: Cregeen, DP
author: Rumsby, G
db: Pubmed
title: Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase
source: Biochim Biophys Acta 1446:383-8
year: 1999

SequenceSite23078
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite23077
type: SequenceSite
position status: EQUAL
sequence position: 402

SequenceSite23079
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23074
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23073
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite23076
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23075
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite23070
type: SequenceSite
position status: EQUAL
sequence position: 524

UniProt:Q9GU73
type: ProteinReference
xref: UnificationXref19990
organism: BioSource1

SequenceSite23072
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23071
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite23048
type: SequenceSite
position status: EQUAL
sequence position: 538

SequenceSite23049
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23043
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23042
type: SequenceSite
position status: EQUAL
sequence position: 338

SequenceSite23041
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23040
type: SequenceSite
position status: EQUAL
sequence position: 538

SequenceSite23047
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23046
type: SequenceSite
position status: EQUAL
sequence position: 538

SequenceSite23045
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23044
type: SequenceSite
position status: EQUAL
sequence position: 338

20-Hydroxy arachidonic acid
type: SmallMoleculeReference
name: 20-HETE
name: 20-Hydroxyicosatetraenoic acid
name: (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
name: 20-Hydroxyeicosatetraenoic acid
name: 20-HETE [ChEBI:34306]
xref: UnificationXref23928

(24S)-24-hydroxycholesterol
type: SmallMoleculeReference
name: ChEBI:34310 (24S)-24-hydroxycholesterol
xref: UnificationXref22612

SequenceSite23059
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite23052
type: SequenceSite
position status: EQUAL
sequence position: 538

SequenceSite23051
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23054
type: SequenceSite
position status: EQUAL
sequence position: 194

SequenceSite23053
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite23056
type: SequenceSite
position status: EQUAL
sequence position: 194

SequenceSite23055
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite23058
type: SequenceSite
position status: EQUAL
sequence position: 194

SequenceSite23057
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite23050
type: SequenceSite
position status: EQUAL
sequence position: 538

http://identifiers.org/pubmed/19359157
type: PublicationXref
id: 19359157
author: Lykke-Andersen, J
author: Rebbapragada, I
db: Pubmed
title: Execution of nonsense-mediated mRNA decay: what defines a substrate?
source: Curr Opin Cell Biol 21:394-402
year: 2009

http://identifiers.org/pubmed/7378348
type: PublicationXref
id: 7378348
author: So, AG
author: Tan, CK
author: Downey, KM
author: Lee, MY
db: Pubmed
title: Purification of deoxyribonucleic acid polymerase delta from calf thymus: partial characterization of physical properties.
source: Biochemistry 19:2096-101
year: 1980

UniProt:Q9BML7
type: ProteinReference
xref: UnificationXref1884
organism: BioSource1

UniProt:Q9BML6
type: ProteinReference
xref: UnificationXref1879
organism: BioSource1

http://identifiers.org/pubmed/10903140
type: PublicationXref
id: 10903140
author: Broer, Stefan
author: Wagner, CA
author: Lang, F
author: Broer, Angelika
db: Pubmed
title: The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine
source: Biochem J 349:787-95
year: 2000

http://identifiers.org/pubmed/12782243
type: PublicationXref
id: 12782243
author: Prézeau, L
author: Galvez, T
author: Pin, JP
db: Pubmed
title: Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors
source: Pharmacol Ther 98:325-54
year: 2003

http://identifiers.org/pubmed/10681567
type: PublicationXref
id: 10681567
author: Suzuki, N
author: Higashino, K
author: Ikeda, M
author: Hanasaki, K
author: Kawamoto, K
author: Ishizaki, J
author: Ono, T
author: Yokota, Y
author: Fujii, N
db: Pubmed
title: Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s
source: J Biol Chem 275:5785-93
year: 2000

http://identifiers.org/pubmed/19261609
type: PublicationXref
id: 19261609
author: Vitvitsky, V
author: Singh, S
author: Banerjee, R
author: Zhu, W
author: Chiku, T
author: Padovani, D
db: Pubmed
title: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia
source: J Biol Chem 284:11601-12
year: 2009

http://identifiers.org/pubmed/171650
type: PublicationXref
id: 171650
author: Harper, E
author: Byers, PH
author: Click, EM
author: Bornstein, P
db: Pubmed
title: Interchain disulfide bonds in procollagen are located in a large nontriple-helical COOH-terminal domain
source: Proc Natl Acad Sci U S A 72:3009-13
year: 1975

http://identifiers.org/pubmed/9268380
type: PublicationXref
id: 9268380
author: Fattaey, A
author: Booher, RN
author: Holman, PS
db: Pubmed
title: Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity
source: J Biol Chem 272:22300-6
year: 1997

http://identifiers.org/pubmed/12151341
type: PublicationXref
id: 12151341
author: Takamori, S
author: Malherbe, P
author: Jahn, R
author: Broger, C
db: Pubmed
title: Molecular cloning and functional characterization of human vesicular glutamate transporter 3
source: EMBO Rep 3:798-803
year: 2002

http://identifiers.org/pubmed/11239147
type: PublicationXref
id: 11239147
author: Stein, E
author: Tessier-Lavigne, M
db: Pubmed
title: Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex
source: Science 291:1928-38
year: 2001

UnificationXref23991
type: UnificationXref
id: 4159140
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159140

UnificationXref23990
type: UnificationXref
id: 4159139
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159139

UnificationXref23993
type: UnificationXref
id: 4159142
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159142

UnificationXref23992
type: UnificationXref
id: 4159141
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159141

UnificationXref23995
type: UnificationXref
id: 4159144
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159144

UnificationXref23994
type: UnificationXref
id: 4159143
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159143

UnificationXref23996
type: UnificationXref
id: 4159145
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159145

UnificationXref23997
type: UnificationXref
id: 4159146
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159146

UnificationXref23998
type: UnificationXref
id: 4159147
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159147

UnificationXref23999
type: UnificationXref
id: 4159154
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159154

UnificationXref23983
type: UnificationXref
id: Q7KVX4
db: UniProt

UnificationXref23984
type: UnificationXref
id: 4159133
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159133

UnificationXref23981
type: UnificationXref
id: 4159128
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159128

http://identifiers.org/pubmed/18767960
type: PublicationXref
id: 18767960
author: Antonellis, A
author: Green, ED
db: Pubmed
title: The role of aminoacyl-tRNA synthetases in genetic diseases
source: Annu Rev Genomics Hum Genet 9:87-107
year: 2008

UnificationXref23982
type: UnificationXref
id: 4159129
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159129

UnificationXref23980
type: UnificationXref
id: Q9XZ28
db: UniProt

UnificationXref23989
type: UnificationXref
id: A9YI35
db: UniProt

UnificationXref23988
type: UnificationXref
id: 4159137
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159137

UnificationXref23987
type: UnificationXref
id: Q7KVX5
db: UniProt

UnificationXref23986
type: UnificationXref
id: 4159135
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159135

UnificationXref23985
type: UnificationXref
id: Q9W4N8
db: UniProt

UnificationXref23970
type: UnificationXref
id: Q9Y128
db: UniProt

UnificationXref23971
type: UnificationXref
id: 4159156
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159156

UnificationXref23972
type: UnificationXref
id: 4159159
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159159

UnificationXref23973
type: UnificationXref
id: Q9VE91
db: UniProt

http://identifiers.org/pubmed/2770297
type: PublicationXref
id: 2770297
author: Thomas, JL
author: Myers, RP
author: Strickler, RC
db: Pubmed
title: Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes
source: J Steroid Biochem 33:209-17
year: 1989

UnificationXref23979
type: UnificationXref
id: 4159126
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159126

UnificationXref23978
type: UnificationXref
id: D8FT19
db: UniProt

UnificationXref23975
type: UnificationXref
id: 4159165
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159165

UnificationXref23974
type: UnificationXref
id: 4159163
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159163

UnificationXref23977
type: UnificationXref
id: 4159151
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4159151

UnificationXref23976
type: UnificationXref
id: REACT_156227
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156227.3

UnificationXref23961
type: UnificationXref
id: 428182
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428182

UnificationXref23962
type: UnificationXref
id: REACT_20257
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20257.1

UnificationXref23960
type: UnificationXref
id: CHEBI:17862
db: ChEBI

http://identifiers.org/pubmed/14638695
type: PublicationXref
id: 14638695
author: Lu, M
author: Haney, LB
author: Brugnera, E
author: Hengartner, MO
author: Tosello-Trampont, AC
author: Klingele, D
author: Ravichandran, KS
author: Kinchen, JM
author: Chen, Q
author: Grimsley, CM
db: Pubmed
title: Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration
source: J Biol Chem 279:6087-97
year: 2004

UnificationXref23966
type: UnificationXref
id: Q9VBU5
db: UniProt

UnificationXref23965
type: UnificationXref
id: REACT_20160
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20160.2

UnificationXref23964
type: UnificationXref
id: 428163
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428163

UnificationXref23963
type: UnificationXref
id: CHEBI:16566
db: ChEBI

UnificationXref23969
type: UnificationXref
id: REACT_90694
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90694.9

UnificationXref23968
type: UnificationXref
id: 4158661
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4158661

UnificationXref23967
type: UnificationXref
id: 4158659
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4158659

UnificationXref23950
type: UnificationXref
id: 2142792
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142792

UnificationXref23951
type: UnificationXref
id: REACT_150932
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150932.1

UnificationXref23953
type: UnificationXref
id: REACT_151174
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151174.1

UnificationXref23952
type: UnificationXref
id: 2161753
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161753

UnificationXref23955
type: UnificationXref
id: REACT_159446
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159446.3

UnificationXref23954
type: UnificationXref
id: 4172642
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172642

PPA2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry4
component: Protein2
xref: UnificationXref31
cellular location: GO:0005759
comment: Reactome DB_ID: 4160430

UnificationXref23957
type: UnificationXref
id: REACT_156015
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156015.3

PPA1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry2
component: Protein1
xref: UnificationXref14
cellular location: GO:0005829
comment: Reactome DB_ID: 4143145

UnificationXref23956
type: UnificationXref
id: 4175895
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175895

Di-peptides
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry7
component: SmallMolecule23
xref: UnificationXref147
xref: UnificationXref148
cellular location: GO:0005576
comment: Reactome DB_ID: 427956

UnificationXref23959
type: UnificationXref
id: REACT_148694
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148694.4

Di-peptides/tri-peptides
type: Complex
data source: Reactome
member physical entity: Tri-peptides
member physical entity: Di-peptides
xref: UnificationXref152
xref: UnificationXref151
cellular location: GO:0005576
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 428037

UnificationXref23958
type: UnificationXref
id: 4175091
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175091

Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction1399
pathway component: BiochemicalReaction1397
pathway component: BiochemicalReaction1404
pathway component: BiochemicalReaction1401
pathway component: BiochemicalReaction1400
pathway component: BiochemicalReaction1403
pathway component: BiochemicalReaction1398
pathway component: BiochemicalReaction1402
evidence: Evidence2114
xref: UnificationXref21005
xref: RelationshipXref1132
xref: UnificationXref21004
pathway order: PathwayStep2105
pathway order: PathwayStep2107
pathway order: PathwayStep2106
pathway order: PathwayStep2109
pathway order: PathwayStep2108
pathway order: PathwayStep2102
pathway order: PathwayStep2103
pathway order: PathwayStep2104
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10652353
type: PublicationXref
id: 10652353
author: Ohashi, K
author: Maekawa, M
author: Mizuno, K
author: Nagata, K
author: Narumiya, S
author: Ishizaki, T
db: Pubmed
title: Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
source: J Biol Chem 275:3577-82
year: 2000

DSCAM interactions
type: Pathway
data source: Reactome
pathway component: DSCAM/DSCAML1 homodimerization
pathway component: Activation of p38MAPK by DSCAM
pathway component: Activation of JNK by DSCAM
pathway component: DSCAM associates with Rac1-GTP:pPAK1
pathway component: DSCAM binds Netrin-1
evidence: Evidence43
xref: UnificationXref629
xref: UnificationXref630
pathway order: PathwayStep36
pathway order: PathwayStep39
pathway order: PathwayStep37
pathway order: PathwayStep38
pathway order: PathwayStep40
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11278486
type: PublicationXref
id: 11278486
author: Chong, C
author: Tan, L
author: Lim, L
author: Manser, E
db: Pubmed
title: The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
source: J Biol Chem 276:17347-53
year: 2001

UniProt:P49028
type: ProteinReference
xref: UnificationXref3712
organism: BioSource1

http://identifiers.org/pubmed/11208594
type: PublicationXref
id: 11208594
author: Rabelink, TJ
author: Govers, R
db: Pubmed
title: Cellular regulation of endothelial nitric oxide synthase
source: Am J Physiol Renal Physiol 280:F193-206
year: 2001

http://identifiers.org/pubmed/12123608
type: PublicationXref
id: 12123608
author: Swiercz, JM
author: Offermanns, S
author: Behrens, J
author: Kuner, R
db: Pubmed
title: Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology
source: Neuron 35:51-63
year: 2002

http://identifiers.org/pubmed/12123609
type: PublicationXref
id: 12123609
author: Snider, WD
author: Zhong, J
author: Markus, A
db: Pubmed
title: Raf and akt mediate distinct aspects of sensory axon growth
source: Neuron 35:65-76
year: 2002

http://identifiers.org/pubmed/9914469
type: PublicationXref
id: 9914469
author: Lang, J
db: Pubmed
title: Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
source: Eur J Biochem 259:3-17
year: 1999

SequenceSite11586
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11587
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite23119
type: SequenceSite
position status: EQUAL
sequence position: 20

SequenceSite11588
type: SequenceSite
position status: EQUAL
sequence position: 250

SequenceSite23118
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11589
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite23117
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23116
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23115
type: SequenceSite
position status: EQUAL
sequence position: 197

SequenceSite23114
type: SequenceSite
position status: EQUAL
sequence position: 192

FGFR2 ligand binding and activation
type: Pathway
data source: Reactome
pathway component: REACT 92496.9
evidence: Evidence794
xref: UnificationXref8573
xref: UnificationXref8574
xref: RelationshipXref460
pathway order: PathwayStep781
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite23112
type: SequenceSite
position status: EQUAL
sequence position: 20

SequenceSite23113
type: SequenceSite
position status: EQUAL
sequence position: 55

SequenceSite23110
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite11581
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite23111
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11580
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11583
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11582
type: SequenceSite
position status: EQUAL
sequence position: 808

SequenceSite11585
type: SequenceSite
position status: EQUAL
sequence position: 250

SequenceSite11584
type: SequenceSite
position status: EQUAL
sequence position: 808

SequenceSite23108
type: SequenceSite
position status: EQUAL
sequence position: 197

SequenceSite11599
type: SequenceSite
position status: EQUAL
sequence position: 367

SequenceSite23107
type: SequenceSite
position status: EQUAL
sequence position: 192

SequenceSite11597
type: SequenceSite
position status: EQUAL
sequence position: 23

http://identifiers.org/pubmed/16761954
type: PublicationXref
id: 16761954
author: De Vuyst, E
author: Leybaert, L
author: Evans, WH
db: Pubmed
title: The gap junction cellular internet: connexin hemichannels enter the signalling limelight
source: Biochem J 397:1-14
year: 2006

SequenceSite23109
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11598
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite23104
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite23103
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23106
type: SequenceSite
position status: EQUAL
sequence position: 55

SequenceSite23105
type: SequenceSite
position status: EQUAL
sequence position: 20

SequenceSite11592
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite23100
type: SequenceSite
position status: EQUAL
sequence position: 192

SequenceSite11591
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite23101
type: SequenceSite
position status: EQUAL
sequence position: 197

SequenceSite11590
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite23102
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11596
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11595
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11594
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11593
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite23138
type: SequenceSite
position status: EQUAL
sequence position: 313

SequenceSite23139
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23136
type: SequenceSite
position status: EQUAL
sequence position: 736

SequenceSite23137
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23131
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23130
type: SequenceSite
position status: EQUAL
sequence position: 736

SequenceSite23135
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23134
type: SequenceSite
position status: EQUAL
sequence position: 736

SequenceSite23133
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23132
type: SequenceSite
position status: EQUAL
sequence position: 736

SequenceSite23125
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23126
type: SequenceSite
position status: EQUAL
sequence position: 736

SequenceSite23127
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23128
type: SequenceSite
position status: EQUAL
sequence position: 736

SequenceSite23129
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/19006241
type: PublicationXref
id: 19006241
author: Häberle, J
author: Höhne, W
author: Engel, K
db: Pubmed
title: Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene
source: Hum Mutat 30:300-7
year: 2009

SequenceSite23120
type: SequenceSite
position status: EQUAL
sequence position: 55

SequenceSite23122
type: SequenceSite
position status: EQUAL
sequence position: 197

SequenceSite23121
type: SequenceSite
position status: EQUAL
sequence position: 192

http://identifiers.org/pubmed/10590411
type: PublicationXref
id: 10590411
author: Foellmer, JW
author: Davis, JI
author: Merezhinskaya, N
author: Fishbein, WN
db: Pubmed
title: Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport
source: Muscle Nerve 23:90-7
year: 2000

SequenceSite23124
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23123
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23158
type: SequenceSite
position status: EQUAL
sequence position: 842

SequenceSite23157
type: SequenceSite
position status: EQUAL
sequence position: 341

SequenceSite23156
type: SequenceSite
position status: EQUAL
sequence position: 778

SequenceSite23155
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23154
type: SequenceSite
position status: EQUAL
sequence position: 778

SequenceSite23153
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23152
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23151
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite23150
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23147
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite23148
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23149
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite23144
type: SequenceSite
position status: EQUAL
sequence position: 313

SequenceSite23143
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite23146
type: SequenceSite
position status: EQUAL
sequence position: 524

SequenceSite23145
type: SequenceSite
position status: EQUAL
sequence position: 213

SequenceSite23140
type: SequenceSite
position status: EQUAL
sequence position: 313

SequenceSite23142
type: SequenceSite
position status: EQUAL
sequence position: 313

SequenceSite23141
type: SequenceSite
position status: EQUAL
sequence position: 1

2'-deoxyguanosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:16497
data source: Reactome
name: Deoxyguanosine 5'-triphosphate
name: Deoxyguanosine triphosphate
xref: UnificationXref19259
xref: UnificationXref19260
cellular location: GO:0005654
comment: Reactome DB_ID: 29892
display name: dGTP

deoxycytidine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:16311
data source: Reactome
name: Deoxycytidine triphosphate
name: 2'-Deoxycytidine 5'-triphosphate
xref: UnificationXref19256
xref: UnificationXref19257
cellular location: GO:0005654
comment: Reactome DB_ID: 30185
display name: dCTP

AMP
type: SmallMolecule
entity reference: CHEBI:16027
data source: Reactome
xref: UnificationXref19024
xref: UnificationXref19025
cellular location: GO:0005654
comment: Reactome DB_ID: 164121

Phosphate
type: SmallMolecule
entity reference: CHEBI:18367
data source: Reactome
name: Orthophosphate
name: Inorganic Phosphate
xref: UnificationXref18946
xref: UnificationXref18947
cellular location: GO:0030659
comment: Reactome DB_ID: 2255331
display name: Pi

Guanosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:17552
data source: Reactome
name: Guanosine diphosphate
xref: UnificationXref18914
xref: UnificationXref18915
cellular location: GO:0030659
comment: Reactome DB_ID: 1996292
display name: GDP

SequenceSite11530
type: SequenceSite
position status: EQUAL
sequence position: 23

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15996
data source: Reactome
xref: UnificationXref18895
xref: UnificationXref18896
cellular location: GO:0030659
comment: Reactome DB_ID: 1996291
display name: GTP

Phosphatidylinositol-3,4,5-trisphosphate
type: SmallMolecule
entity reference: SmallMoleculeReference192
data source: Reactome
name: PI(3,4,5)P3
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
xref: UnificationXref18881
xref: UnificationXref18880
cellular location: GO:0030666
comment: Reactome DB_ID: 917725
display name: PIP3

SequenceSite11531
type: SequenceSite
position status: EQUAL
sequence position: 806

Oxygen
type: SmallMolecule
entity reference: CHEBI:15379
data source: Reactome
xref: UnificationXref19415
xref: UnificationXref19416
cellular location: GO:0005788
comment: Reactome DB_ID: 113534
display name: O2

SequenceSite11532
type: SequenceSite
position status: EQUAL
sequence position: 380

alpha-ketoglutarate
type: SmallMolecule
entity reference: CHEBI:30915
data source: Reactome
name: 2-Oxoglutarate
xref: UnificationXref19418
xref: UnificationXref19417
cellular location: GO:0005788
comment: Reactome DB_ID: 1650779
display name: 2OG

SequenceSite11533
type: SequenceSite
position status: EQUAL
sequence position: 23

Deoxythymidine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:18077
data source: Reactome
name: dTTP
name: Deoxythymidine triphosphate
xref: UnificationXref19263
xref: UnificationXref19262
cellular location: GO:0005654
comment: Reactome DB_ID: 30187
display name: TTP

SequenceSite11534
type: SequenceSite
position status: EQUAL
sequence position: 806

2'-deoxyadenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:16284
data source: Reactome
name: Deoxyadenosine 5'-triphosphate
name: Deoxyadenosine triphosphate
xref: UnificationXref19266
xref: UnificationXref19265
cellular location: GO:0005654
comment: Reactome DB_ID: 29604
display name: dATP

SequenceSite11535
type: SequenceSite
position status: EQUAL
sequence position: 382

SequenceSite11536
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11537
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11538
type: SequenceSite
position status: EQUAL
sequence position: 382

SequenceSite11539
type: SequenceSite
position status: EQUAL
sequence position: 23

http://identifiers.org/pubmed/12205100
type: PublicationXref
id: 12205100
author: Van Komen, S
author: Sigurdsson, S
author: Petukhova, G
author: Sung, P
db: Pubmed
title: Homologous DNA pairing by human recombination factors Rad51 and Rad54
source: J Biol Chem 277:42790-4
year: 2002

UnificationXref23602
type: UnificationXref
id: 4175082
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175082

UnificationXref23603
type: UnificationXref
id: REACT_141607
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141607.5

UnificationXref23600
type: UnificationXref
id: 4175840
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175840

UnificationXref23601
type: UnificationXref
id: REACT_147558
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147558.5

UnificationXref23606
type: UnificationXref
id: CHEBI:27432
db: ChEBI

UnificationXref23607
type: UnificationXref
id: 2046056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046056

UnificationXref23604
type: UnificationXref
id: 211579
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211579

UnificationXref23605
type: UnificationXref
id: REACT_119727
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_119727.1

proton
type: SmallMolecule
entity reference: CHEBI:15378
data source: Reactome
xref: UnificationXref17563
xref: UnificationXref17562
cellular location: GO:0031096
comment: Reactome DB_ID: 427899
display name: H+

(R)-2-hydroxyglutaric acid
type: SmallMolecule
entity reference: CHEBI:32796
data source: Reactome
name: (R)-2-hydroxyglutarate
xref: UnificationXref17461
xref: UnificationXref17462
cellular location: GO:0005829
comment: Reactome DB_ID: 880042
display name: 2HG

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:16761
data source: Reactome
xref: UnificationXref17722
xref: UnificationXref17723
cellular location: GO:0031089
comment: Reactome DB_ID: 114565
display name: ADP

UnificationXref23608
type: UnificationXref
id: REACT_121509
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121509.1

http://identifiers.org/pubmed/4218100
type: PublicationXref
id: 4218100
author: Matalon, R
author: Brandt, IK
author: Dorfman, A
author: Justice, P
author: Arbogast, B
db: Pubmed
title: Morquio's syndrome: deficiency of a chondroitin sulfate N-acetylhexosamine sulfate sulfatase
source: Biochem Biophys Res Commun 61:759-65
year: 1974

Calcium
type: SmallMolecule
entity reference: CHEBI:29108
data source: Reactome
xref: UnificationXref17564
xref: UnificationXref17565
cellular location: GO:0031096
comment: Reactome DB_ID: 139827
display name: Ca2+

UnificationXref23609
type: UnificationXref
id: 2046064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046064

perifosine
type: SmallMolecule
entity reference: CHEBI:428891
data source: Reactome
xref: UnificationXref17246
xref: UnificationXref17247
cellular location: GO:0005829
comment: Reactome DB_ID: 2399924
display name: KRX-041

AKT inhibitors
type: SmallMolecule
data source: Reactome
member physical entity: MK2206
member physical entity: Triciribine
member physical entity: perifosine
xref: UnificationXref17254
xref: UnificationXref17255
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2399923

Triciribine
type: SmallMolecule
entity reference: CHEBI:65310
data source: Reactome
name: API-2
name: VQD-002
xref: UnificationXref17252
xref: UnificationXref17253
cellular location: GO:0005829
comment: Reactome DB_ID: 2404226
display name: TCN

MK2206
type: SmallMolecule
entity reference: CHEBI:716367
data source: Reactome
xref: UnificationXref17250
xref: UnificationXref17249
cellular location: GO:0005829
comment: Reactome DB_ID: 2399927

SequenceSite11522
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11523
type: SequenceSite
position status: EQUAL
sequence position: 23

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15996
data source: Reactome
xref: UnificationXref18223
xref: UnificationXref18222
cellular location: GO:0005759
comment: Reactome DB_ID: 113573
display name: GTP

SequenceSite11520
type: SequenceSite
position status: EQUAL
sequence position: 806

Guanosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:17552
data source: Reactome
name: Guanosine diphosphate
xref: UnificationXref18224
xref: UnificationXref18225
cellular location: GO:0005759
comment: Reactome DB_ID: 113525
display name: GDP

SequenceSite11521
type: SequenceSite
position status: EQUAL
sequence position: 23

Phosphatidylinositol-3,4,5-trisphosphate
type: SmallMolecule
entity reference: SmallMoleculeReference192
data source: Reactome
name: PI(3,4,5)P3
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
xref: UnificationXref18822
xref: UnificationXref18823
cellular location: GO:0010008
comment: Reactome DB_ID: 917716
display name: PIP3

SequenceSite11526
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11527
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11524
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11525
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11528
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11529
type: SequenceSite
position status: EQUAL
sequence position: 380

UnificationXref23615
type: UnificationXref
id: REACT_121476
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121476.1

UnificationXref23616
type: UnificationXref
id: 4172307
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172307

UnificationXref23617
type: UnificationXref
id: 4172309
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172309

IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl
type: SmallMolecule
entity reference: CHEBI:63873
data source: Reactome
xref: UnificationXref17104
xref: UnificationXref17105
cellular location: GO:0043202
comment: Reactome DB_ID: 2105025

UnificationXref23618
type: UnificationXref
id: REACT_139424
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139424.5

UnificationXref23611
type: UnificationXref
id: 2046049
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046049

UnificationXref23612
type: UnificationXref
id: REACT_122430
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122430.1

UnificationXref23613
type: UnificationXref
id: CHEBI:51985
db: ChEBI

UnificationXref23614
type: UnificationXref
id: 2046062
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046062

GlcA-Gal-Gal-Xyl linker chain
type: SmallMolecule
entity reference: CHEBI:63505
data source: Reactome
xref: UnificationXref16941
xref: UnificationXref16942
cellular location: GO:0043202
comment: Reactome DB_ID: 2065212
display name: CS/HS precursor

Heparan chain(2)
type: SmallMolecule
entity reference: CHEBI:63645
data source: Reactome
xref: UnificationXref16936
xref: UnificationXref16937
cellular location: GO:0043202
comment: Reactome DB_ID: 2090053

Heparan chain(1)
type: SmallMolecule
entity reference: CHEBI:63811
data source: Reactome
xref: UnificationXref16931
xref: UnificationXref16932
cellular location: GO:0043202
comment: Reactome DB_ID: 2090045

Heparan sulfate chain(7)
type: SmallMolecule
entity reference: CHEBI:63810
data source: Reactome
xref: UnificationXref16927
xref: UnificationXref16926
cellular location: GO:0043202
comment: Reactome DB_ID: 2090070

ChEBI:63516 chain
type: SmallMolecule
entity reference: CHEBI:63516
data source: Reactome
xref: UnificationXref17099
xref: UnificationXref17100
cellular location: GO:0043202
comment: Reactome DB_ID: 2065269

UnificationXref23619
type: UnificationXref
id: CHEBI:63540
db: ChEBI

ChEBI:63517 chain
type: SmallMolecule
entity reference: CHEBI:63517
data source: Reactome
xref: UnificationXref17096
xref: UnificationXref17097
cellular location: GO:0043202
comment: Reactome DB_ID: 2065213

phys-ent-participant8466
type: SmallMolecule
entity reference: CHEBI:15936
data source: Reactome
xref: UnificationXref16949
xref: UnificationXref16950
cellular location: GO:0043202
comment: Reactome DB_ID: 2090063
display name: D-xylose

Gal-Gal-Xyl- chain
type: SmallMolecule
entity reference: CHEBI:63503
data source: Reactome
xref: UnificationXref16947
xref: UnificationXref16946
cellular location: GO:0043202
comment: Reactome DB_ID: 2090075
display name: linker chain(2)

SequenceSite11513
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11514
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11515
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11516
type: SequenceSite
position status: EQUAL
sequence position: 806

CHEBI:63868 chain
type: SmallMolecule
entity reference: CHEBI:63868
data source: Reactome
xref: UnificationXref17107
xref: UnificationXref17108
cellular location: GO:0043202
comment: Reactome DB_ID: 2104993

SequenceSite11510
type: SequenceSite
position status: EQUAL
sequence position: 806

Palmitic acid
type: SmallMolecule
entity reference: CHEBI:15756
data source: Reactome
name: Palmitate
xref: UnificationXref17142
xref: UnificationXref17143
cellular location: GO:0005769
comment: Reactome DB_ID: 76168
display name: PALM

SequenceSite11511
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11512
type: SequenceSite
position status: EQUAL
sequence position: 806

UnificationXref23610
type: UnificationXref
id: REACT_122294
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122294.1

SequenceSite11517
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11518
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11519
type: SequenceSite
position status: EQUAL
sequence position: 23

Heparan sulfate chain(6)
type: SmallMolecule
entity reference: CHEBI:63809
data source: Reactome
xref: UnificationXref16902
xref: UnificationXref16901
cellular location: GO:0043202
comment: Reactome DB_ID: 2090055

UnificationXref23628
type: UnificationXref
id: REACT_123653
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123653.1

Heparan sulfate chain(5)
type: SmallMolecule
entity reference: CHEBI:63808
data source: Reactome
xref: UnificationXref16894
xref: UnificationXref16895
cellular location: GO:0043202
comment: Reactome DB_ID: 2090080

UnificationXref23629
type: UnificationXref
id: 4172342
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172342

UnificationXref23626
type: UnificationXref
id: CHEBI:65139
db: ChEBI

UnificationXref23627
type: UnificationXref
id: 2066767
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066767

UnificationXref23624
type: UnificationXref
id: 4172311
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172311

UnificationXref23625
type: UnificationXref
id: REACT_130170
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130170.5

UnificationXref23622
type: UnificationXref
id: 2046047
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046047

UnificationXref23623
type: UnificationXref
id: REACT_124358
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124358.1

adenosine 3',5'-bisphosphate
type: SmallMolecule
entity reference: CHEBI:17985
data source: Reactome
xref: UnificationXref16411
xref: UnificationXref16410
cellular location: GO:0005796
comment: Reactome DB_ID: 742343
display name: PAP

Acetate
type: SmallMolecule
entity reference: CHEBI:15366
data source: Reactome
name: Ethanoic acid
name: Acetic acid
xref: UnificationXref16401
xref: UnificationXref16402
cellular location: GO:0005796
comment: Reactome DB_ID: 2022890
display name: CH3COO-

Heparan sulfate chain(2)
type: SmallMolecule
entity reference: CHEBI:63805
data source: Reactome
xref: UnificationXref16868
xref: UnificationXref16867
cellular location: GO:0043202
comment: Reactome DB_ID: 2090072

Heparan sulfate chain(1)
type: SmallMolecule
entity reference: CHEBI:63666
data source: Reactome
xref: UnificationXref16865
xref: UnificationXref16864
cellular location: GO:0043202
comment: Reactome DB_ID: 2090033

Heparan sulfate chain(3)
type: SmallMolecule
entity reference: CHEBI:63806
data source: Reactome
xref: UnificationXref16877
xref: UnificationXref16878
cellular location: GO:0043202
comment: Reactome DB_ID: 2090040

L-Iduronic acid
type: SmallMolecule
entity reference: CHEBI:28481
data source: Reactome
xref: UnificationXref16871
xref: UnificationXref16870
cellular location: GO:0043202
comment: Reactome DB_ID: 1678617

N-acetyl-D-glucosamine
type: SmallMolecule
entity reference: CHEBI:17411
data source: Reactome
name: N-acetylglucosamine
xref: UnificationXref16892
xref: UnificationXref16891
cellular location: GO:0043202
comment: Reactome DB_ID: 1678743
display name: GlcNAc

Heparan sulfate chain(4)
type: SmallMolecule
entity reference: CHEBI:63807
data source: Reactome
xref: UnificationXref16884
xref: UnificationXref16885
cellular location: GO:0043202
comment: Reactome DB_ID: 2090069

SequenceSite11504
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11505
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11502
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11503
type: SequenceSite
position status: EQUAL
sequence position: 373

SequenceSite11500
type: SequenceSite
position status: EQUAL
sequence position: 371

SequenceSite11501
type: SequenceSite
position status: EQUAL
sequence position: 23

Calcium
type: SmallMolecule
entity reference: CHEBI:29108
data source: Reactome
xref: UnificationXref16915
xref: UnificationXref16914
cellular location: GO:0043202
comment: Reactome DB_ID: 1606834
display name: Ca2+

http://identifiers.org/pubmed/20930137
type: PublicationXref
id: 20930137
author: Kull, FJ
author: Endow, SA
author: Liu, H
db: Pubmed
title: Kinesins at a glance
source: J Cell Sci 123:3420-4
year: 2010

UnificationXref23621
type: UnificationXref
id: REACT_123619
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123619.1

UnificationXref23620
type: UnificationXref
id: 2046054
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046054

SequenceSite11508
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11509
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11506
type: SequenceSite
position status: EQUAL
sequence position: 373

SequenceSite11507
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11570
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11571
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11572
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11573
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11574
type: SequenceSite
position status: EQUAL
sequence position: 806

UnificationXref23634
type: UnificationXref
id: 4172340
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172340

UnificationXref23633
type: UnificationXref
id: REACT_121859
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121859.1

UnificationXref23636
type: UnificationXref
id: CHEBI:65131
db: ChEBI

UnificationXref23635
type: UnificationXref
id: REACT_147340
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147340.5

UnificationXref23638
type: UnificationXref
id: REACT_124098
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124098.1

UnificationXref23637
type: UnificationXref
id: 2066762
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066762

UnificationXref23639
type: UnificationXref
id: 4172341
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172341

UnificationXref23630
type: UnificationXref
id: REACT_142767
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142767.5

UnificationXref23631
type: UnificationXref
id: CHEBI:65130
db: ChEBI

UnificationXref23632
type: UnificationXref
id: 2066766
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066766

SequenceSite11576
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11575
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11578
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11577
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11579
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11562
type: SequenceSite
position status: EQUAL
sequence position: 806

lactose
type: SmallMolecule
entity reference: CHEBI:36219
data source: Reactome
xref: UnificationXref19678
xref: UnificationXref19677
cellular location: GO:0005576
comment: Reactome DB_ID: 188973
display name: Lac

SequenceSite11563
type: SequenceSite
position status: EQUAL
sequence position: 23

alpha-D-glucose
type: SmallMolecule
entity reference: CHEBI:17925
data source: Reactome
xref: UnificationXref19680
xref: UnificationXref19679
cellular location: GO:0005576
comment: Reactome DB_ID: 70115
display name: Glc

SequenceSite11560
type: SequenceSite
position status: EQUAL
sequence position: 806

D-galactose
type: SmallMolecule
entity reference: CHEBI:17118
data source: Reactome
xref: UnificationXref19683
xref: UnificationXref19682
cellular location: GO:0005576
comment: Reactome DB_ID: 188995
display name: Gal

SequenceSite11561
type: SequenceSite
position status: EQUAL
sequence position: 23

alpha,alpha-trehalose
type: SmallMolecule
entity reference: CHEBI:16551
data source: Reactome
xref: UnificationXref19690
xref: UnificationXref19691
cellular location: GO:0005576
comment: Reactome DB_ID: 189078

UnificationXref23647
type: UnificationXref
id: 2046063
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046063

UnificationXref23646
type: UnificationXref
id: CHEBI:15530
db: ChEBI

UnificationXref23645
type: UnificationXref
id: REACT_124018
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124018.1

UnificationXref23644
type: UnificationXref
id: 2046044
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046044

UnificationXref23649
type: UnificationXref
id: 4172313
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172313

UnificationXref23648
type: UnificationXref
id: REACT_121841
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121841.1

UnificationXref23642
type: UnificationXref
id: REACT_133227
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133227.5

UnificationXref23643
type: UnificationXref
id: CHEBI:17351
db: ChEBI

UnificationXref23640
type: UnificationXref
id: REACT_137062
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137062.5

UnificationXref23641
type: UnificationXref
id: 4175886
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175886

SequenceSite11567
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11566
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11565
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11564
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11569
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11568
type: SequenceSite
position status: EQUAL
sequence position: 806

3-hydroxybutyrate
type: SmallMolecule
entity reference: CHEBI:37054
data source: Reactome
name: Beta-hydroxybutyrate
xref: UnificationXref19615
xref: UnificationXref19614
cellular location: GO:0005576
comment: Reactome DB_ID: 433678
display name: bHBA

SequenceSite11550
type: SequenceSite
position status: EQUAL
sequence position: 697

Pyruvate
type: SmallMolecule
entity reference: CHEBI:32816
data source: Reactome
name: Pyruvic acid
name: Pyroracemic acid
name: 2-Oxopropanoate
name: 2-Oxopropanoic acid
xref: UnificationXref19617
xref: UnificationXref19616
cellular location: GO:0005576
comment: Reactome DB_ID: 429750
display name: PYR

SequenceSite11551
type: SequenceSite
position status: EQUAL
sequence position: 23

L-Lactic acid
type: SmallMolecule
entity reference: CHEBI:422
data source: Reactome
name: L-Lactate
name: (S)-Lactate
xref: UnificationXref19608
xref: UnificationXref19609
cellular location: GO:0005576
comment: Reactome DB_ID: 373863
display name: LACT

SequenceSite11552
type: SequenceSite
position status: EQUAL
sequence position: 806

beta-Ketobutyric acid
type: SmallMolecule
entity reference: CHEBI:15344
data source: Reactome
name: Acetoacetic acid
name: Acetoacetate
name: 3-Oxobutanoic acid
xref: UnificationXref19612
xref: UnificationXref19611
cellular location: GO:0005576
comment: Reactome DB_ID: 433680
display name: ACA

UniProt:P49071
type: ProteinReference
xref: UnificationXref5514
organism: BioSource1

MCT substrates
type: SmallMolecule
data source: Reactome
member physical entity: 3-hydroxybutyrate
member physical entity: Acetoacetate
member physical entity: L-Lactic acid
member physical entity: Pyruvate
xref: UnificationXref19627
xref: UnificationXref19628
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 433686

UnificationXref23659
type: UnificationXref
id: REACT_127297
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127297.5

UnificationXref23656
type: UnificationXref
id: 4172312
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172312

UnificationXref23655
type: UnificationXref
id: REACT_123939
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123939.1

UnificationXref23658
type: UnificationXref
id: 4175888
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175888

UnificationXref23657
type: UnificationXref
id: REACT_132748
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132748.5

UnificationXref23651
type: UnificationXref
id: CHEBI:63546
db: ChEBI

UnificationXref23652
type: UnificationXref
id: 2046050
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046050

UnificationXref23653
type: UnificationXref
id: REACT_123419
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123419.1

UnificationXref23654
type: UnificationXref
id: 2046055
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2046055

UnificationXref23650
type: UnificationXref
id: REACT_126599
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126599.5

SequenceSite11558
type: SequenceSite
position status: EQUAL
sequence position: 806

Acetoacetate
type: SmallMolecule
entity reference: CHEBI:13705
data source: Reactome
name: 3-Oxobutanoate
xref: UnificationXref19624
xref: UnificationXref19623
cellular location: GO:0005829
comment: Reactome DB_ID: 29666
display name: ACA

SequenceSite11557
type: SequenceSite
position status: EQUAL
sequence position: 23

L-Lactic acid
type: SmallMolecule
entity reference: CHEBI:422
data source: Reactome
name: L-Lactate
name: (S)-Lactate
xref: UnificationXref19621
xref: UnificationXref19620
cellular location: GO:0005829
comment: Reactome DB_ID: 29708
display name: LACT

SequenceSite11559
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11554
type: SequenceSite
position status: EQUAL
sequence position: 806

limit dextrins
type: SmallMolecule
entity reference: CHEBI:28912
data source: Reactome
xref: UnificationXref19673
xref: UnificationXref19672
cellular location: GO:0005576
comment: Reactome DB_ID: 189108

SequenceSite11553
type: SequenceSite
position status: EQUAL
sequence position: 23

maltotriose
type: SmallMolecule
entity reference: CHEBI:27931
data source: Reactome
xref: UnificationXref19645
xref: UnificationXref19646
cellular location: GO:0005576
comment: Reactome DB_ID: 191103

SequenceSite11556
type: SequenceSite
position status: EQUAL
sequence position: 806

maltose
type: SmallMolecule
entity reference: CHEBI:17306
data source: Reactome
xref: UnificationXref19643
xref: UnificationXref19642
cellular location: GO:0005576
comment: Reactome DB_ID: 188986
display name: Mal

SequenceSite11555
type: SequenceSite
position status: EQUAL
sequence position: 23

3-hydroxybutyrate
type: SmallMolecule
entity reference: CHEBI:37054
data source: Reactome
name: Beta-hydroxybutyrate
xref: UnificationXref19626
xref: UnificationXref19625
cellular location: GO:0005829
comment: Reactome DB_ID: 433685
display name: bHBA

SequenceSite11540
type: SequenceSite
position status: EQUAL
sequence position: 806

Ethylenesuccinic acid
type: SmallMolecule
entity reference: CHEBI:15741
data source: Reactome
name: Butanedionic acid
name: Succinate
name: Succinic acid
xref: UnificationXref19425
xref: UnificationXref19426
cellular location: GO:0005788
comment: Reactome DB_ID: 1650769
display name: SUCCA

SequenceSite11541
type: SequenceSite
position status: EQUAL
sequence position: 650

Carbon dioxide
type: SmallMolecule
entity reference: CHEBI:16526
data source: Reactome
xref: UnificationXref19427
xref: UnificationXref19428
cellular location: GO:0005788
comment: Reactome DB_ID: 159751
display name: CO2

iron (ferrous)
type: SmallMolecule
entity reference: CHEBI:18248
data source: Reactome
name: Fe(II)
name: Fe++
xref: UnificationXref19430
xref: UnificationXref19429
cellular location: GO:0005789
comment: Reactome DB_ID: 1981115
display name: Fe2+

UDP-D-galactopyranose
type: SmallMolecule
entity reference: CHEBI:18307
data source: Reactome
name: UDPgalactose
name: UDP-D-galactose
xref: UnificationXref19457
xref: UnificationXref19456
cellular location: GO:0005788
comment: Reactome DB_ID: 1981137
display name: UDP-Gal

inorganic sulfate
type: SmallMolecule
entity reference: CHEBI:16189
data source: Reactome
name: Sulphate
xref: UnificationXref19554
xref: UnificationXref19553
cellular location: GO:0005576
comment: Reactome DB_ID: 427648
display name: SO4(2-)

Dicarboxylates transported by NaDC1
type: SmallMolecule
data source: Reactome
member physical entity: Ethylenesuccinic acid
member physical entity: Citrate
xref: UnificationXref19579
xref: UnificationXref19578
cellular location: GO:0005576
comment: Reactome DB_ID: 433111
comment: Converted from EntitySet in Reactome

http://identifiers.org/pubmed/17765544
type: PublicationXref
id: 17765544
author: Cote, Jean-Francois
author: Vuori, K
db: Pubmed
title: GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
source: Trends Cell Biol 17:383-93
year: 2007

http://identifiers.org/pubmed/10487978
type: PublicationXref
id: 10487978
author: Walsh, DA
author: Brushia, RJ
db: Pubmed
title: Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure
source: Front Biosci 4:D618-41
year: 1999

UnificationXref23669
type: UnificationXref
id: REACT_153576
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153576.3

UnificationXref23668
type: UnificationXref
id: 4172576
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172576

UnificationXref23667
type: UnificationXref
id: REACT_24606
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24606.2

UnificationXref23666
type: UnificationXref
id: 879535
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879535

UnificationXref23664
type: UnificationXref
id: REACT_15800
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15800.2

UnificationXref23665
type: UnificationXref
id: CHEBI:15553
db: ChEBI

UnificationXref23662
type: UnificationXref
id: CHEBI:15554
db: ChEBI

UnificationXref23663
type: UnificationXref
id: 265283
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265283

UnificationXref23660
type: UnificationXref
id: 4175887
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175887

UnificationXref23661
type: UnificationXref
id: REACT_137028
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137028.5

SequenceSite11549
type: SequenceSite
position status: EQUAL
sequence position: 806

SequenceSite11548
type: SequenceSite
position status: EQUAL
sequence position: 23

SequenceSite11547
type: SequenceSite
position status: EQUAL
sequence position: 697

Citrate
type: SmallMolecule
entity reference: CHEBI:30769
data source: Reactome
xref: UnificationXref19574
xref: UnificationXref19575
cellular location: GO:0005576
comment: Reactome DB_ID: 433138
display name: CIT

SequenceSite11546
type: SequenceSite
position status: EQUAL
sequence position: 806

http://identifiers.org/pubmed/12151002
type: PublicationXref
id: 12151002
author: Paiement, J
author: Desjardins, M
author: Bergeron, JJ
author: Cameron, PH
author: Duclos, S
author: Chevet, E
author: Gagnon, E
author: Steele-Mortimer, O
author: Rondeau, C
db: Pubmed
title: Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages
source: Cell 110:119-31
year: 2002

SequenceSite11545
type: SequenceSite
position status: EQUAL
sequence position: 23

Dicarboxylates transported by NaDC1
type: SmallMolecule
data source: Reactome
member physical entity: Ethylenesuccinic acid
member physical entity: Citrate
xref: UnificationXref19583
xref: UnificationXref19582
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 433124

SequenceSite11544
type: SequenceSite
position status: EQUAL
sequence position: 650

Ethylenesuccinic acid
type: SmallMolecule
entity reference: CHEBI:15741
data source: Reactome
name: Butanedionic acid
name: Succinate
name: Succinic acid
xref: UnificationXref19576
xref: UnificationXref19577
cellular location: GO:0005576
comment: Reactome DB_ID: 433123
display name: SUCCA

SequenceSite11543
type: SequenceSite
position status: EQUAL
sequence position: 806

MCT substrates
type: SmallMolecule
data source: Reactome
member physical entity: beta-Ketobutyric acid
member physical entity: L-Lactic acid
member physical entity: 3-hydroxybutyrate
member physical entity: Pyruvate
xref: UnificationXref19619
xref: UnificationXref19618
cellular location: GO:0005576
comment: Reactome DB_ID: 433683
comment: Converted from EntitySet in Reactome

SequenceSite11542
type: SequenceSite
position status: EQUAL
sequence position: 23

Citrate
type: SmallMolecule
entity reference: CHEBI:30769
data source: Reactome
xref: UnificationXref19580
xref: UnificationXref19581
cellular location: GO:0005829
comment: Reactome DB_ID: 76190
display name: CIT

UnificationXref23672
type: UnificationXref
id: REACT_15804
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15804.2

UnificationXref23671
type: UnificationXref
id: 265287
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265287

UnificationXref23670
type: UnificationXref
id: CHEBI:15551
db: ChEBI

UnificationXref23676
type: UnificationXref
id: D3DMY1
db: UniProt

UnificationXref23675
type: UnificationXref
id: REACT_150596
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150596.1

UnificationXref23674
type: UnificationXref
id: 2239524
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2239524

UnificationXref23673
type: UnificationXref
id: CHEBI:16856
db: ChEBI

UnificationXref23679
type: UnificationXref
id: 4172582
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172582

UnificationXref23677
type: UnificationXref
id: 4172581
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172581

UnificationXref23678
type: UnificationXref
id: E4NKK2
db: UniProt

http://identifiers.org/pubmed/9593664
type: PublicationXref
id: 9593664
author: Maehama, T
author: Dixon, JE
db: Pubmed
title: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
source: J Biol Chem 273:13375-8
year: 1998

UnificationXref23681
type: UnificationXref
id: 4172583
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172583

UnificationXref23680
type: UnificationXref
id: D2NUI8
db: UniProt

UnificationXref23683
type: UnificationXref
id: 4172584
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172584

UnificationXref23682
type: UnificationXref
id: F6JCF1
db: UniProt

UnificationXref23685
type: UnificationXref
id: 4172585
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172585

UnificationXref23684
type: UnificationXref
id: Q8SY70
db: UniProt

UnificationXref23687
type: UnificationXref
id: 4172586
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172586

UnificationXref23686
type: UnificationXref
id: F6JCG5
db: UniProt

UnificationXref23688
type: UnificationXref
id: F6J6V4
db: UniProt

UnificationXref23689
type: UnificationXref
id: 4172587
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172587

UnificationXref23690
type: UnificationXref
id: Q86B54
db: UniProt

UnificationXref23698
type: UnificationXref
id: Q8SY19
db: UniProt

UnificationXref23697
type: UnificationXref
id: 4172591
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172591

UnificationXref23696
type: UnificationXref
id: O97471
db: UniProt

UnificationXref23695
type: UnificationXref
id: 4172590
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172590

UnificationXref23694
type: UnificationXref
id: Q8SY97
db: UniProt

UnificationXref23693
type: UnificationXref
id: 4172589
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172589

UnificationXref23692
type: UnificationXref
id: F6JCF7
db: UniProt

UnificationXref23691
type: UnificationXref
id: 4172588
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172588

UnificationXref23699
type: UnificationXref
id: 4172592
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172592

UniProt:P18289
type: ProteinReference
xref: UnificationXref14834
organism: BioSource1

Signaling by the B Cell Receptor (BCR)
type: Pathway
data source: Reactome
pathway component: REACT 120473.6
pathway component: REACT 120477.6
evidence: Evidence3169
xref: UnificationXref30620
xref: UnificationXref30619
pathway order: PathwayStep3148
pathway order: PathwayStep3156
display name: B Cell Activation
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

GlcNAc(S)-Gal-GlcNAc(S)-Gal
type: SmallMolecule
entity reference: CHEBI:63851
data source: Reactome
xref: UnificationXref15987
xref: UnificationXref15986
cellular location: GO:0043202
comment: Reactome DB_ID: 2104995

sulfate
type: SmallMolecule
entity reference: CHEBI:16189
data source: Reactome
xref: UnificationXref15997
xref: UnificationXref15996
cellular location: GO:0043202
comment: Reactome DB_ID: 1606845
display name: SO4(2-)

GlcNAc-Gal-GlcNAc(S)-Gal
type: SmallMolecule
entity reference: CHEBI:63852
data source: Reactome
xref: UnificationXref16000
xref: UnificationXref15999
cellular location: GO:0043202
comment: Reactome DB_ID: 2105012

UDP-xylose
type: SmallMolecule
entity reference: CHEBI:16082
data source: Reactome
xref: UnificationXref16016
xref: UnificationXref16017
cellular location: GO:0005796
comment: Reactome DB_ID: 742361
display name: UDP-xyl

Water
type: SmallMolecule
entity reference: CHEBI:15377
data source: Reactome
xref: UnificationXref15978
xref: UnificationXref15977
cellular location: GO:0043202
comment: Reactome DB_ID: 1605715
display name: H2O

Gal-GlcNAc(S)-Gal-GlcNAc(S)-Gal
type: SmallMolecule
entity reference: CHEBI:63850
data source: Reactome
xref: UnificationXref15981
xref: UnificationXref15980
cellular location: GO:0043202
comment: Reactome DB_ID: 2104997

alpha-D-galactose
type: SmallMolecule
entity reference: CHEBI:28061
data source: Reactome
xref: UnificationXref15984
xref: UnificationXref15983
cellular location: GO:0043202
comment: Reactome DB_ID: 1605637
display name: Gal

UDP-glucuronic acid
type: SmallMolecule
entity reference: CHEBI:17200
data source: Reactome
xref: UnificationXref16186
xref: UnificationXref16187
cellular location: GO:0005796
comment: Reactome DB_ID: 1889970
display name: UDP-GlcA

Mn(III)
type: SmallMolecule
entity reference: CHEBI:18291
data source: Reactome
name: Mn(II)
name: Manganese
xref: UnificationXref16220
xref: UnificationXref16221
cellular location: GO:0000139
comment: Reactome DB_ID: 1524074
display name: Mn2+

Water
type: SmallMolecule
entity reference: CHEBI:15377
data source: Reactome
xref: UnificationXref16372
xref: UnificationXref16371
cellular location: GO:0005796
comment: Reactome DB_ID: 2022884
display name: H2O

http://identifiers.org/pubmed/12515866
type: PublicationXref
id: 12515866
author: Nakamura, S
author: Suzuki, N
author: Kozasa, T
author: Mano, H
db: Pubmed
title: Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF
source: Proc Natl Acad Sci U S A 100:733-8
year: 2003

UniProt:Q9BPQ9
type: ProteinReference
xref: UnificationXref495
organism: BioSource1

http://identifiers.org/pubmed/11023514
type: PublicationXref
id: 11023514
author: Zhang, J
author: Roifman, CM
author: Chitayat, D
author: Sharfe, N
db: Pubmed
title: A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency
source: Blood 96:2803-7
year: 2000

UniProt:Q9BPQ3
type: ProteinReference
xref: UnificationXref18184
organism: BioSource1

PAPS
type: SmallMolecule
entity reference: CHEBI:17980
data source: Reactome
xref: UnificationXref15950
xref: UnificationXref15949
cellular location: GO:0005796
comment: Reactome DB_ID: 741440

UniProt:Q9BPQ2
type: ProteinReference
xref: UnificationXref18182
organism: BioSource1

UDP-sugar substrates of SLC35D2
type: SmallMolecule
data source: Reactome
member physical entity: UDP-GlcNAc
member physical entity: UDPglucose
xref: UnificationXref15962
xref: UnificationXref15963
cellular location: GO:0005829
comment: Reactome DB_ID: 744229
comment: Converted from EntitySet in Reactome
display name: UDP-sugars

5'-adenylyl sulfate
type: SmallMolecule
entity reference: CHEBI:17709
data source: Reactome
name: Adenosine 5'-phosphosulfate
xref: UnificationXref15923
xref: UnificationXref15922
cellular location: GO:0005829
comment: Reactome DB_ID: 174370
display name: APS

PAPS
type: SmallMolecule
entity reference: CHEBI:17980
data source: Reactome
xref: UnificationXref15946
xref: UnificationXref15945
cellular location: GO:0005829
comment: Reactome DB_ID: 158471

3-Anthraniloyl-L-alanine
type: SmallMolecule
entity reference: CHEBI:16946
data source: Reactome
name: L-Kynurenine
xref: UnificationXref15911
xref: UnificationXref15912
cellular location: GO:0005829
comment: Reactome DB_ID: 29970
display name: L-KYN

4-(2-aminophenyl)-2,4-dioxobutanoic acid
type: SmallMolecule
entity reference: CHEBI:17442
data source: Reactome
xref: UnificationXref15915
xref: UnificationXref15914
cellular location: GO:0005829
comment: Reactome DB_ID: 893615

http://identifiers.org/pubmed/14716310
type: PublicationXref
id: 14716310
author: Espevik, T
author: Schoenemeyer, A
author: Lien, E
author: Knetter, CF
author: Latz, E
author: Monks, BG
author: Golenbock, DT
author: Visintin, A
author: Fitzgerald, Katherine A
author: Nilsen, NJ
db: Pubmed
title: TLR9 signals after translocating from the ER to CpG DNA in the lysosome
source: Nat Immunol 5:190-8
year: 2004

http://identifiers.org/pubmed/17637696
type: PublicationXref
id: 17637696
author: Gerondakis, S
author: Banerjee, A
db: Pubmed
title: Coordinating TLR-activated signaling pathways in cells of the immune system
source: Immunol Cell Biol 85:420-4
year: 2007

UDP-sugar substrates of SLC35D2
type: SmallMolecule
data source: Reactome
member physical entity: UDPglucose
member physical entity: UDP-N-acetylglucosamine
xref: UnificationXref15969
xref: UnificationXref15968
cellular location: GO:0005796
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 744234
display name: UDP-sugars

UDPglucose
type: SmallMolecule
entity reference: CHEBI:18066
data source: Reactome
name: UDP-D-glucose
name: UDP-glucose
xref: UnificationXref15967
xref: UnificationXref15966
cellular location: GO:0005796
comment: Reactome DB_ID: 744227
display name: UDP-Glc

UDP-GlcNAc
type: SmallMolecule
entity reference: CHEBI:16264
data source: Reactome
xref: UnificationXref15961
xref: UnificationXref15960
cellular location: GO:0005829
comment: Reactome DB_ID: 741437

uridine 5'-monophosphate
type: SmallMolecule
entity reference: CHEBI:16695
data source: Reactome
name: Uridine monophosphate
name: uridylic acid
name: 5'Uridylic acid
xref: UnificationXref15964
xref: UnificationXref15965
cellular location: GO:0005796
comment: Reactome DB_ID: 735698
display name: UMP

http://identifiers.org/pubmed/21029861
type: PublicationXref
id: 21029861
author: Hogg, JR
author: Goff, SP
db: Pubmed
title: Upf1 senses 3'UTR length to potentiate mRNA decay
source: Cell 143:379-89
year: 2010

http://identifiers.org/pubmed/11278511
type: PublicationXref
id: 11278511
author: Ding, WC
author: Berger, SH
author: Lebioda, L
author: Koli, S
author: Minor, W
author: Dunlap, RB
author: Phan, J
author: Steadman, DJ
db: Pubmed
title: Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
source: J Biol Chem 276:14170-7
year: 2001

Lenvatinib
type: SmallMolecule
entity reference: CHEBI:816009
data source: Reactome
xref: UnificationXref15616
xref: UnificationXref15617
cellular location: GO:0005829
comment: Reactome DB_ID: 2023393
display name: E7080

Tyrosine kinase inhibitors of overexpressed FGFR2
type: SmallMolecule
data source: Reactome
member physical entity: Cediranib
member physical entity: BGJ398
member physical entity: PD173074
member physical entity: AZD4547
xref: UnificationXref15644
xref: UnificationXref15645
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2029965

Tyrosine kinase inhibitors of FGFR3 mutants
type: SmallMolecule
data source: Reactome
member physical entity: Dovitinib
member physical entity: SU5402
member physical entity: E3810
member physical entity: PD173074
member physical entity: BGJ398
member physical entity: AZD4547
member physical entity: Lenvatinib
member physical entity: Midostaurin
member physical entity: Masitinib
xref: UnificationXref15795
xref: UnificationXref15794
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2077416

Masitinib
type: SmallMolecule
entity reference: CHEBI:63450
data source: Reactome
xref: UnificationXref15792
xref: UnificationXref15793
cellular location: GO:0005829
comment: Reactome DB_ID: 2077524
display name: AB1010

5,6,7,8-Tetrahydrobiopterin
type: SmallMolecule
entity reference: CHEBI:15372
data source: Reactome
name: 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-pteridinone
name: Tetrahydrobiopterin
xref: UnificationXref15868
xref: UnificationXref15867
cellular location: GO:0005829
comment: Reactome DB_ID: 29870
display name: BH4

4a-hydroxytetrahydrobiopterin
type: SmallMolecule
entity reference: CHEBI:15374
data source: Reactome
xref: UnificationXref15870
xref: UnificationXref15871
cellular location: GO:0005829
comment: Reactome DB_ID: 71112

Oxalacetic acid
type: SmallMolecule
entity reference: CHEBI:30744
data source: Reactome
name: Oxosuccinic acid
name: 2-oxobutanedioic acid
name: Oxaloacetic acid
name: Oxaloacetate
xref: UnificationXref15880
xref: UnificationXref15881
cellular location: GO:0005829
comment: Reactome DB_ID: 76213
display name: OA

keto-phenylpyruvate
type: SmallMolecule
entity reference: CHEBI:18005
data source: Reactome
xref: UnificationXref15883
xref: UnificationXref15884
cellular location: GO:0005829
comment: Reactome DB_ID: 2160487

phenyllactate
type: SmallMolecule
entity reference: CHEBI:8100
data source: Reactome
xref: UnificationXref15895
xref: UnificationXref15896
cellular location: GO:0005829
comment: Reactome DB_ID: 2160481

Pyruvate
type: SmallMolecule
entity reference: CHEBI:32816
data source: Reactome
name: Pyruvic acid
name: Pyroracemic acid
name: 2-Oxopropanoate
name: 2-Oxopropanoic acid
xref: UnificationXref15909
xref: UnificationXref15908
cellular location: GO:0005829
comment: Reactome DB_ID: 29398
display name: PYR

http://identifiers.org/pubmed/11278508
type: PublicationXref
id: 11278508
author: Chairoungdua, A
author: Kanai, Y
author: Kim, DK
author: Matsuo, H
author: Cha, SH
author: Endou, H
db: Pubmed
title: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters
source: J Biol Chem 276:17221-8
year: 2001

http://identifiers.org/pubmed/10536157
type: PublicationXref
id: 10536157
author: Wu, X
author: Zhang, Y
author: Xin, H
author: Lin, W
author: Yuan, F
db: Pubmed
title: The human REV1 gene codes for a DNA template-dependent dCMP transferase.
source: Nucleic Acids Res 27:4468-75
year: 1999

http://identifiers.org/pubmed/13115431
type: PublicationXref
id: 13115431
author: Lieberman, I
author: Kornberg, A
db: Pubmed
title: Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase
source: Biochim Biophys Acta 12:223-234
year: 1953

http://identifiers.org/pubmed/13115432
type: PublicationXref
id: 13115432
author: Cori, GT
author: Keller, PJ
db: Pubmed
title: Enzymic conversion of phosphorylase a to phosphorylase b
source: Biochim Biophys Acta 12:235-8
year: 1953

http://identifiers.org/pubmed/13295248
type: PublicationXref
id: 13295248
author: Stern, JR
author: Del Campillo, A
db: Pubmed
title: Enzymes of fatty acid metabolism. II. Properties of crystalline crotonase.
source: J Biol Chem 218:985-1002
year: 1956

http://identifiers.org/pubmed/22952392
type: PublicationXref
id: 22952392
author: Nusse, Roel
author: Willert, Karl
db: Pubmed
title: Wnt proteins
source: Cold Spring Harb Perspect Biol 4:a007864
year: 2012

http://identifiers.org/pubmed/9634703
type: PublicationXref
id: 9634703
author: Párraga, A
author: Bellsolell, L
author: Burley, SK
author: Ferré-D'Amaré, AR
db: Pubmed
title: Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution
source: Structure 6:661-72
year: 1998

Ghost homologue of DNAJC5
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1224
cellular location: GO:0061202
comment: Reactome DB_ID: 4162901

Ghost homologue of RAB3A
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1182
cellular location: GO:0060201
comment: Reactome DB_ID: 4154562

GluR3,GluR4
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1402
cellular location: GO:0030666
display name: GRIA3,GRIA4
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4157369
member physical entity: Protein470
member physical entity: Protein476

Ghost homologue of RAB3A
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1225
cellular location: GO:0061202
comment: Reactome DB_ID: 4162915

Ghost homologue of RAB3A
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1141
cellular location: GO:0060203
comment: Reactome DB_ID: 4154135

Phospho(S221,S363,S380,T573)- ribosomal S6 kinase
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1631
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4159796
member physical entity: Protein605
member physical entity: Protein597
member physical entity: Protein609
member physical entity: Protein601

Ribosomal S6 kinase
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1573
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4159978
member physical entity: Protein557
member physical entity: Protein553
member physical entity: Protein561
member physical entity: Protein549

GluR3/GluR4
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1443
cellular location: GO:0005886
display name: GRIA3,GRIA4
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4157131
member physical entity: Protein506
member physical entity: Protein512

Phospho(S363,S380,T573)- ribosomal S6 kinase
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1610
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4159839
member physical entity: Protein589
member physical entity: Protein585
member physical entity: Protein581
member physical entity: Protein593

Phospho(S363,S380,T573)-ribosomal S6 kinase
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1590
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4159995
member physical entity: Protein573
member physical entity: Protein569
member physical entity: Protein577
member physical entity: Protein565

http://identifiers.org/pubmed/11752451
type: PublicationXref
id: 11752451
author: Hafen, E
author: Stocker, H
author: Rintelen, F
author: Thomas, G
db: Pubmed
title: PDK1 regulates growth through Akt and S6K in Drosophila.
source: Proc Natl Acad Sci U S A 98:15020-5
year: 2001

Kir3.x channels
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2075
cellular location: GO:0005886
comment: Reactome DB_ID: 4165092
comment: Converted from EntitySet in Reactome
member physical entity: Protein894
member physical entity: Protein860
member physical entity: Protein877
member physical entity: Protein843

Kirx.x that interacts with Kir2.1
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2005
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4165022
member physical entity: Protein775
member physical entity: Protein809
member physical entity: Protein826
member physical entity: Protein792

Ghost homologue of G-protein Gamma subunits
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1897
cellular location: GO:0005886
comment: Reactome DB_ID: 4164912

Ghost homologue of GABRAs
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1866
cellular location: GO:0005886
comment: Reactome DB_ID: 4164039

GABA(A) receptor gamma subunits
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1865
cellular location: GO:0005886
display name: GABRGs
comment: Reactome DB_ID: 4164065
comment: Converted from EntitySet in Reactome
member physical entity: Protein737
member physical entity: Protein732

Ca/calmodulin activated Adenylate Cyclase
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1666
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4159777
member physical entity: Protein620
member physical entity: Protein625
member physical entity: Protein616

Kv3 subunits of voltage gated potassium channels
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2325
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4166235
member physical entity: Protein1068
member physical entity: Protein1065
member physical entity: Protein1074
member physical entity: Protein1071

Kv12 subunit of voltage gated potassium channels
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2306
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4166223
member physical entity: Protein1047
member physical entity: Protein1057
member physical entity: Protein1052

Voltage gated potassium channel subunits Kv1-12
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2363
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4166260
member physical entity: Kv3 subunits of voltage gated potassium channels
member physical entity: Kv12 subunit of voltage gated potassium channels
member physical entity: Protein1077
member physical entity: Protein1043
member physical entity: Protein1031
member physical entity: Protein1062
member physical entity: Kv7 subunits of voltage gated potassium channels
member physical entity: Protein1040

Kir channels 2x
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2260
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4166173
member physical entity: Protein758
member physical entity: Protein1014
member physical entity: Protein809
member physical entity: Protein792

http://identifiers.org/pubmed/10652257
type: PublicationXref
id: 10652257
author: Wakelam, MJ
author: Cross, MJ
author: Roberts, S
author: Claesson-Welsh, L
author: Landgren, E
author: Hodgkin, MN
db: Pubmed
title: Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells
source: J Cell Sci 113:643-51
year: 2000

http://identifiers.org/pubmed/10496324
type: PublicationXref
id: 10496324
author: Dharmawardhane, S
author: Lennartz, M
author: Bokoch, GM
author: Brownson, D
db: Pubmed
title: Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils
source: J Leukoc Biol 66:521-7
year: 1999

http://identifiers.org/pubmed/12324224
type: PublicationXref
id: 12324224
author: Sprecher, H
db: Pubmed
title: The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids
source: Prostaglandins Leukot Essent Fatty Acids 67:79-83
year: 2002

http://identifiers.org/pubmed/11533233
type: PublicationXref
id: 11533233
author: Fox, PL
author: Sonenberg, N
author: Imataka, H
author: Seshadri, V
author: Mazumder, B
db: Pubmed
title: Translational silencing of ceruloplasmin requires the essential elements of mRNA circularization: poly(A) tail, poly(A)-binding protein, and eukaryotic translation initiation factor 4G
source: Mol Cell Biol 21:6440-9
year: 2001

Ghost homologue of 5.8S rRNA
type: PhysicalEntity
data source: Reactome
xref: UnificationXref770
cellular location: GO:0005829
comment: Reactome DB_ID: 4144575

Ghost homologue of RPL36A
type: PhysicalEntity
data source: Reactome
xref: UnificationXref725
cellular location: GO:0005829
comment: Reactome DB_ID: 4144546

Ghost homologue of 5S rRNA
type: PhysicalEntity
data source: Reactome
xref: UnificationXref724
cellular location: GO:0005829
comment: Reactome DB_ID: 4144574

Ghost homologue of 28S rRNA
type: PhysicalEntity
data source: Reactome
xref: UnificationXref714
cellular location: GO:0005829
comment: Reactome DB_ID: 4144576

Ghost homologue of 18S rRNA
type: PhysicalEntity
data source: Reactome
xref: UnificationXref832
cellular location: GO:0005829
comment: Reactome DB_ID: 4144094

Ghost homologue of RPS27
type: PhysicalEntity
data source: Reactome
xref: UnificationXref822
cellular location: GO:0005829
comment: Reactome DB_ID: 4144031

fMet-tRNA
type: PhysicalEntity
data source: Reactome
name: methionyl initiator tRNA
name: Met-tRNAf
xref: UnificationXref799
xref: UnificationXref800
cellular location: GO:0005829
display name: Met-tRNAi
comment: Reactome DB_ID: 72393

http://identifiers.org/pubmed/17371249
type: PublicationXref
id: 17371249
author: Wu, H
author: Backer, JM
author: Yan, Y
db: Pubmed
title: Regulation of class IA PI3Ks
source: Biochem Soc Trans 35:242-4
year: 2007

http://identifiers.org/pubmed/9188776
type: PublicationXref
id: 9188776
author: Rider, MH
author: Veiga-da-Cunha, M
author: Gerin, I
author: Van Schaftingen, E
author: Collet, JF
db: Pubmed
title: Human L-3-phosphoserine phosphatase: sequence, expression and evidence for a phosphoenzyme intermediate
source: FEBS Lett 408:281-4
year: 1997

Ghost homologue of PABPC1
type: PhysicalEntity
data source: Reactome
xref: UnificationXref798
cellular location: GO:0005829
comment: Reactome DB_ID: 4147804

Ghost homologue of RAB3A
type: PhysicalEntity
data source: Reactome
xref: UnificationXref1034
cellular location: GO:0070083
comment: Reactome DB_ID: 4155536

Ghost homologue of Ceruloplasmin mRNA
type: PhysicalEntity
data source: Reactome
xref: UnificationXref962
cellular location: GO:0005829
comment: Reactome DB_ID: 4147800

elongating pre-mRNA Pol III oligonucleotide
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3047
xref: UnificationXref3048
cellular location: GO:0005654
comment: Reactome DB_ID: 111980

UniProt:Q1WWE3
type: ProteinReference
xref: UnificationXref17589
organism: BioSource1

Tyrosine kinase inhibitors of FGFR2 mutants
type: SmallMolecule
data source: Reactome
member physical entity: SU5402
member physical entity: BGJ398
member physical entity: E3810
member physical entity: PD173074
member physical entity: AZD4547
member physical entity: Lenvatinib
xref: UnificationXref15619
xref: UnificationXref15618
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2077403

Ghost homologue of SNAPC4
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3158
cellular location: GO:0005654
comment: Reactome DB_ID: 4147292

Midostaurin
type: SmallMolecule
entity reference: CHEBI:63452
data source: Reactome
xref: UnificationXref15408
xref: UnificationXref15407
cellular location: GO:0005829
comment: Reactome DB_ID: 2038921
display name: PKC412

Tyrosine kinase inhibitors of FGFR1 fusion mutants
type: SmallMolecule
data source: Reactome
member physical entity: Dovitinib
member physical entity: SU5402
member physical entity: PD173074
member physical entity: Midostaurin
xref: UnificationXref15409
xref: UnificationXref15410
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2045079

DNA with RNA Polymerase III Type 3 Open Promoter
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3148
xref: UnificationXref3147
cellular location: GO:0005654
comment: Reactome DB_ID: 112135

Ghost homologue of BRF2
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3156
cellular location: GO:0005654
comment: Reactome DB_ID: 4147294

DNA with RNA Polymerase III Type 2 Open Promoter
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3141
xref: UnificationXref3142
cellular location: GO:0005654
comment: Reactome DB_ID: 112134

http://identifiers.org/pubmed/10615129
type: PublicationXref
id: 10615129
author: Mauro, T
author: Ikeda, S
author: Bonifas, JM
author: Beech, J
author: Bench, G
author: Ogawa, H
author: Hu, Z
author: Shigihara, T
author: Epstein EH, Jr
db: Pubmed
title: Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease
source: Nat Genet 24:61-5
year: 2000

Ghost homologue of ZNF143
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3146
cellular location: GO:0005654
comment: Reactome DB_ID: 4147307

Ghost homologue of GTF3C4
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3112
cellular location: GO:0005654
comment: Reactome DB_ID: 4146216

released pre-mRNA Pol III oligonucleotide
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3137
xref: UnificationXref3138
cellular location: GO:0005654
comment: Reactome DB_ID: 111984

DNA with RNA Polymerase III Type 1 Open Promoter
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3101
xref: UnificationXref3100
cellular location: GO:0005654
comment: Reactome DB_ID: 112051

Ghost homologue of GTF3C2
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3102
cellular location: GO:0005654
comment: Reactome DB_ID: 4146230

Ghost homologue of SNAPC1
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3162
cellular location: GO:0005654
comment: Reactome DB_ID: 4147286

Ghost homologue of SNAPC5
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3159
cellular location: GO:0005654
comment: Reactome DB_ID: 4147291

DNA with RNA Polymerase III Type 1 Closed Promoter
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3178
xref: UnificationXref3177
cellular location: GO:0005654
comment: Reactome DB_ID: 76050

DNA with RNA Polymerase III Type 2 Closed Promoter
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3184
xref: UnificationXref3185
cellular location: GO:0005654
comment: Reactome DB_ID: 83747

DNA with RNA Polymerase III Type 3 Closed Promoter
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3192
xref: UnificationXref3191
cellular location: GO:0005654
comment: Reactome DB_ID: 83752

paused pre-mRNA Pol III transcript
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3198
xref: UnificationXref3199
cellular location: GO:0005654
comment: Reactome DB_ID: 112475

Ghost homologue of SNAPC2
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3163
cellular location: GO:0005654
comment: Reactome DB_ID: 4147285

Polymerase III gene DNA with transcription bubble (single-stranded region)
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3169
xref: UnificationXref3168
cellular location: GO:0005654
comment: Reactome DB_ID: 113443

elongating pre-mRNA Pol III transcript
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3171
xref: UnificationXref3172
cellular location: GO:0005654
comment: Reactome DB_ID: 111987

elongating pre-mRNA Pol III transcript plus 1 nucleotide
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3173
xref: UnificationXref3174
cellular location: GO:0005654
comment: Reactome DB_ID: 113704

TGIF
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2855
cellular location: GO:0005654
comment: Reactome DB_ID: 4172812
comment: Converted from EntitySet in Reactome
member physical entity: Protein1345
member physical entity: Protein1350

SKI/SKIL
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2773
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4149722
member physical entity: Protein1283
member physical entity: Protein1304

RNF111/SMURF2
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2779
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4172833
member physical entity: Protein1325
member physical entity: Protein1241

Voltage-gated K+ channel beta subunits
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2383
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4166282
member physical entity: Protein1105
member physical entity: Protein1110
member physical entity: Protein1115

NR
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2498
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4155767
member physical entity: Protein1138
member physical entity: Protein1161
member physical entity: Protein1163
member physical entity: Protein1146
member physical entity: Protein1152
member physical entity: Protein1167
member physical entity: Protein1172
member physical entity: Protein1174
member physical entity: Protein1147
member physical entity: Protein1159
member physical entity: Protein1142
member physical entity: Protein1164
member physical entity: Protein1151
member physical entity: Protein1153
member physical entity: Protein1175
member physical entity: Protein1162
member physical entity: Protein1176
member physical entity: Protein1160
member physical entity: Protein1157
member physical entity: Protein1158
member physical entity: Protein1156
member physical entity: Protein1150
member physical entity: Protein1171
member physical entity: Protein1173
member physical entity: Protein1170

Formation of the active cofactor, UDP-glucuronate
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction2022
pathway component: BiochemicalReaction1323
pathway component: BiochemicalReaction2021
evidence: Evidence2914
xref: RelationshipXref2004
xref: UnificationXref27639
xref: UnificationXref27640
pathway order: PathwayStep2908
pathway order: PathwayStep2010
pathway order: PathwayStep2907
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Kv7 subunits of voltage gated potassium channels
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2362
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4166259
member physical entity: Protein1097
member physical entity: Protein1089
member physical entity: Protein1081

p-T,2S-SMAD2/3
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2599
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4172779
member physical entity: Protein1227
member physical entity: Protein1223

NCOR corepressor protein
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2710
cellular location: GO:0005654
display name: NCOR
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4149733
member physical entity: Protein1280
member physical entity: Protein1277

Phospho-R-SMAD
type: PhysicalEntity
data source: Reactome
name: p-S465/423,467/425-SMAD2/3
xref: UnificationXref2567
cellular location: GO:0005829
display name: p-2S-SMAD2/3
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4149514
member physical entity: Protein1199
member physical entity: Protein1203

Phospho-R-SMAD
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2587
cellular location: GO:0005654
display name: p-2S-SMAD2/3
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4149656
member physical entity: Protein1215
member physical entity: Protein1219

UniProt:Q1WWF6
type: ProteinReference
xref: UnificationXref16971
organism: BioSource1

UniProt:Q1WWF2
type: ProteinReference
xref: UnificationXref17901
organism: BioSource1

Ghost homologue of UBTF
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3021
cellular location: GO:0005654
comment: Reactome DB_ID: 4144857

elongating pre-rRNA transcript
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3040
xref: UnificationXref3039
cellular location: GO:0005654
comment: Reactome DB_ID: 74985

p-2S-SMAD2/PAR-2S-SMAD3
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2883
cellular location: GO:0005654
comment: Reactome DB_ID: 4172863
comment: Converted from EntitySet in Reactome
member physical entity: Protein1215
member physical entity: Protein1364

R-SMAD2/3
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2909
cellular location: GO:0005654
display name: SMAD2/3
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4154061
member physical entity: Protein1373
member physical entity: Protein1377

R-SMAD2/3
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2922
cellular location: GO:0005829
display name: SMAD2/3
comment: Reactome DB_ID: 4165330
comment: Converted from EntitySet in Reactome
member physical entity: Protein1381
member physical entity: Protein1385

Ghost homologue of p-UBTF
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3008
cellular location: GO:0005654
comment: Reactome DB_ID: 4144784

rDNA Promoter
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3009
xref: UnificationXref3010
cellular location: GO:0005654
comment: Reactome DB_ID: 73682

Ghost homologue of TAF1C
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3014
cellular location: GO:0005654
comment: Reactome DB_ID: 4144779

Ghost homologue of TAF1B
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3015
cellular location: GO:0005654
comment: Reactome DB_ID: 4144781

Ghost homologue of TAF1A
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3016
cellular location: GO:0005654
comment: Reactome DB_ID: 4144780

UnificationXref23700
type: UnificationXref
id: F6JCH9
db: UniProt

UnificationXref23702
type: UnificationXref
id: F6J6U7
db: UniProt

UnificationXref23701
type: UnificationXref
id: 4172593
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172593

UnificationXref23704
type: UnificationXref
id: F6JCG6
db: UniProt

UnificationXref23703
type: UnificationXref
id: 4172594
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172594

UnificationXref23706
type: UnificationXref
id: F6J6W5
db: UniProt

UnificationXref23705
type: UnificationXref
id: 4172595
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172595

UnificationXref23708
type: UnificationXref
id: 4172597
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172597

UnificationXref23707
type: UnificationXref
id: 4172596
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172596

UnificationXref23709
type: UnificationXref
id: 4172598
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172598

http://identifiers.org/pubmed/13295225
type: PublicationXref
id: 13295225
author: Crane, FL
author: Beinert, H
db: Pubmed
title: On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. II. The electron-transferring flavoprotein.
source: J Biol Chem 218:717-31
year: 1956

UniProt:Q1WWC9
type: ProteinReference
xref: UnificationXref9478
organism: BioSource1

released pre-mRNA Pol III transcript
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3214
xref: UnificationXref3215
cellular location: GO:0005654
comment: Reactome DB_ID: 112478

mitochondrial DNA promoter
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3260
xref: UnificationXref3259
cellular location: GO:0005759
comment: Reactome DB_ID: 163305

Polymerase III gene DNA with a termination site
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3211
xref: UnificationXref3212
cellular location: GO:0005654
comment: Reactome DB_ID: 113448

Elongating transcript in processive Pol II mediated elongation
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3408
xref: UnificationXref3409
cellular location: GO:0005654
comment: Reactome DB_ID: 113717

DNA containing Pol II promoter with transcript with 2 or 3 nucleotides
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3349
xref: UnificationXref3348
cellular location: GO:0005654
comment: Reactome DB_ID: 110068

template DNA:4-9 nucleotide transcript hybrid
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3343
xref: UnificationXref3344
cellular location: GO:0005654
comment: Reactome DB_ID: 75897

template DNA with first transcript dinucleotide, opened to +8 position
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3338
xref: UnificationXref3339
cellular location: GO:0005654
comment: Reactome DB_ID: 109877

Open DNA -10 to +2 containing RNA Polymerase II promoter
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3453
xref: UnificationXref3452
cellular location: GO:0005654
comment: Reactome DB_ID: 109875

damaged DNA substrate:nascent mRNA hybrid
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3449
xref: UnificationXref3448
cellular location: GO:0005654
comment: Reactome DB_ID: 110291

capped pre-mRNA
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3438
xref: UnificationXref3439
cellular location: GO:0005654
comment: Reactome DB_ID: 72085

UniProt:Q1WWB2
type: ProteinReference
xref: UnificationXref23849
organism: BioSource1

DNA containing RNA Polymerase II promoter
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3456
xref: UnificationXref3455
cellular location: GO:0005654
comment: Reactome DB_ID: 109627

template DNA opened from -10 to +2, with first nucleotide base-paired at 5'-end
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3481
xref: UnificationXref3480
cellular location: GO:0005654
comment: Reactome DB_ID: 71063

Template DNA hybrid with phosphodiester-PPi intermediate
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3486
xref: UnificationXref3487
cellular location: GO:0005654
comment: Reactome DB_ID: 83602

template DNA:3 nucleotide transcript hybrid
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3498
xref: UnificationXref3497
cellular location: GO:0005654
comment: Reactome DB_ID: 75858

template DNA:9 nucleotide transcript hybrid
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3508
xref: UnificationXref3507
cellular location: GO:0005654
comment: Reactome DB_ID: 75888

template DNA:4 nucleotide transcript hybrid
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3502
xref: UnificationXref3503
cellular location: GO:0005654
comment: Reactome DB_ID: 75884

template DNA:30 nt transcript hybrid
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3517
xref: UnificationXref3518
cellular location: GO:0005654
comment: Reactome DB_ID: 111260

template DNA:11 nucleotide transcript hybrid
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3512
xref: UnificationXref3513
cellular location: GO:0005654
comment: Reactome DB_ID: 75901

Elongating transcript prior to separation
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3573
xref: UnificationXref3572
cellular location: GO:0005654
comment: Reactome DB_ID: 113714

template:capped transcript hybrid
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3560
xref: UnificationXref3561
cellular location: GO:0005654
comment: Reactome DB_ID: 113424

(9Z)-octadec-9-enoic acid
type: SmallMolecule
entity reference: CHEBI:16196
data source: Reactome
name: Oleic acid
xref: UnificationXref12260
xref: UnificationXref12259
cellular location: GO:0005811
comment: Reactome DB_ID: 2864104
display name: OLEA

linoleic acid
type: SmallMolecule
entity reference: SmallMoleculeReference213
data source: Reactome
xref: UnificationXref12256
xref: UnificationXref12257
cellular location: GO:0005811
comment: Reactome DB_ID: 2864095
display name: LINA

fatty acids
type: SmallMolecule
data source: Reactome
member physical entity: Palmitic acid
member physical entity: (9Z)-octadec-9-enoic acid
member physical entity: linoleic acid
member physical entity: stearate
xref: UnificationXref12266
xref: UnificationXref12267
cellular location: GO:0005811
comment: Reactome DB_ID: 2864103
comment: Converted from EntitySet in Reactome
display name: FAs

all-trans-retinyl stearate
type: SmallMolecule
entity reference: CHEBI:70761
data source: Reactome
xref: UnificationXref12253
xref: UnificationXref12252
cellular location: GO:0005811
comment: Reactome DB_ID: 2864102
display name: atR-STEA

Cyclic GMP
type: SmallMolecule
entity reference: CHEBI:16356
data source: Reactome
name: Guanosine 3',5'-cyclic phosphate
name: Guanosine 3',5'-cyclic monophosphate
name: 3',5'-Cyclic GMP
xref: UnificationXref12309
xref: UnificationXref12308
cellular location: GO:0005829
comment: Reactome DB_ID: 30991
display name: cGMP

11-cis-retinol
type: SmallMolecule
entity reference: CHEBI:16302
data source: Reactome
xref: UnificationXref12269
xref: UnificationXref12270
cellular location: GO:0005829
comment: Reactome DB_ID: 30927
display name: 11cROL

stearate
type: SmallMolecule
entity reference: CHEBI:9254
data source: Reactome
xref: UnificationXref12264
xref: UnificationXref12265
cellular location: GO:0005811
comment: Reactome DB_ID: 2864100
display name: STEA

Palmitic acid
type: SmallMolecule
entity reference: CHEBI:15756
data source: Reactome
name: Palmitate
xref: UnificationXref12261
xref: UnificationXref12262
cellular location: GO:0005811
comment: Reactome DB_ID: 2453691
display name: PALM

UnificationXref23736
type: UnificationXref
id: REACT_151444
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151444.1

UnificationXref23737
type: UnificationXref
id: P91615
db: UniProt

ferriprotoheme IX
type: SmallMolecule
entity reference: CHEBI:36144
data source: Reactome
xref: UnificationXref12641
xref: UnificationXref12642
cellular location: GO:0005829
comment: Reactome DB_ID: 1237011
display name: ferriheme b

UnificationXref23738
type: UnificationXref
id: 4172604
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172604

ferriprotoheme IX
type: SmallMolecule
entity reference: CHEBI:36144
data source: Reactome
xref: UnificationXref12398
xref: UnificationXref12397
cellular location: GO:0005654
comment: Reactome DB_ID: 1368125
display name: ferriheme b

UnificationXref23739
type: UnificationXref
id: B7Z061
db: UniProt

UnificationXref23732
type: UnificationXref
id: CHEBI:28442
db: ChEBI

UnificationXref23733
type: UnificationXref
id: 2142799
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142799

UnificationXref23734
type: UnificationXref
id: REACT_152334
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152334.1

http://identifiers.org/pubmed/9844003
type: PublicationXref
id: 9844003
author: Leonhard, S
author: Bittiger, H
author: Pfaff, T
author: Kaupmann, K
author: Bettler, B
author: Karschin, A
author: Froestl, W
author: Schuler, V
author: Bischoff, S
author: Heid, J
author: Mosbacher, J
db: Pubmed
title: Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels
source: Proc Natl Acad Sci U S A 95:14991-6
year: 1998

UnificationXref23735
type: UnificationXref
id: 2161597
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161597

UnificationXref23731
type: UnificationXref
id: REACT_151184
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151184.1

UnificationXref23730
type: UnificationXref
id: 2142721
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142721

SequenceSite11638
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11639
type: SequenceSite
position status: EQUAL
sequence position: 422

SequenceSite11634
type: SequenceSite
position status: EQUAL
sequence position: 247

SequenceSite11635
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11636
type: SequenceSite
position status: EQUAL
sequence position: 422

SequenceSite11637
type: SequenceSite
position status: EQUAL
sequence position: 247

SequenceSite11630
type: SequenceSite
position status: EQUAL
sequence position: 452

2-oxoglutarate
type: SmallMolecule
entity reference: CHEBI:30915
data source: Reactome
name: alpha-ketoglutarate
name: Oxoglutaric acid
name: 2-Oxoglutarate
name: alpha-Ketoglutaric acid
name: 2-Ketoglutaric acid
xref: UnificationXref12796
xref: UnificationXref12795
cellular location: GO:0005829
comment: Reactome DB_ID: 29406
display name: 2OG

SequenceSite11631
type: SequenceSite
position status: EQUAL
sequence position: 40

SequenceSite11632
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11633
type: SequenceSite
position status: EQUAL
sequence position: 452

http://identifiers.org/pubmed/10397761
type: PublicationXref
id: 10397761
author: Sato, R
author: Nagoshi, E
author: Yoneda, Y
author: Imamoto, N
db: Pubmed
title: Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip
source: Mol Biol Cell 10:2221-33
year: 1999

all-trans-retinal
type: SmallMolecule
entity reference: CHEBI:17898
data source: Reactome
xref: UnificationXref12146
xref: UnificationXref12147
cellular location: GO:0005829
comment: Reactome DB_ID: 975622
display name: atRAL

NADP+
type: SmallMolecule
entity reference: CHEBI:18009
data source: Reactome
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref12164
xref: UnificationXref12163
cellular location: GO:0005829
comment: Reactome DB_ID: 29366
display name: TPN

http://identifiers.org/pubmed/9792662
type: PublicationXref
id: 9792662
author: Morgunov, I
author: Srere, PA
db: Pubmed
title: Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate
source: J Biol Chem 273:29540-29544
year: 1998

NADPH
type: SmallMolecule
entity reference: CHEBI:16474
data source: Reactome
xref: UnificationXref12161
xref: UnificationXref12160
cellular location: GO:0005829
comment: Reactome DB_ID: 29364
display name: TPNH

Vitamin A1
type: SmallMolecule
entity reference: CHEBI:17336
data source: Reactome
name: Retinol
name: Vitamin A
name: all-trans-Retinol
xref: UnificationXref12228
xref: UnificationXref12229
cellular location: GO:0005829
comment: Reactome DB_ID: 2473616
display name: atROL

Vitamin A1
type: SmallMolecule
entity reference: CHEBI:17336
data source: Reactome
name: Retinol
name: Vitamin A
name: all-trans-Retinol
xref: UnificationXref12219
xref: UnificationXref12218
cellular location: GO:0005829
comment: Reactome DB_ID: 2473610
display name: atROL

all-trans-retinyl esters (HSC)
type: SmallMolecule
data source: Reactome
member physical entity: all-trans-retinyl linoleate
member physical entity: all-trans-retinyl stearate
member physical entity: all-trans-retinyl palmitate
member physical entity: all-trans-retinyl oleate
xref: UnificationXref12254
cellular location: GO:0005811
comment: Reactome DB_ID: 3651085
comment: Converted from EntitySet in Reactome
display name: atREs

Vitamin A1
type: SmallMolecule
entity reference: CHEBI:17336
data source: Reactome
name: Retinol
name: Vitamin A
name: all-trans-Retinol
xref: UnificationXref12237
xref: UnificationXref12238
cellular location: GO:0005829
comment: Reactome DB_ID: 2473604
display name: atROL

all-trans-retinyl oleate
type: SmallMolecule
entity reference: CHEBI:70760
data source: Reactome
xref: UnificationXref12248
xref: UnificationXref12247
cellular location: GO:0005811
comment: Reactome DB_ID: 2864096
display name: atR-OLEA

UnificationXref23749
type: UnificationXref
id: P00334
db: UniProt

all-trans-retinyl linoleate
type: SmallMolecule
entity reference: CHEBI:70762
data source: Reactome
xref: UnificationXref12245
xref: UnificationXref12244
cellular location: GO:0005811
comment: Reactome DB_ID: 2864098
display name: atR-LINA

UnificationXref23747
type: UnificationXref
id: Q7KNR7
db: UniProt

all-trans-retinyl palmitate
type: SmallMolecule
entity reference: CHEBI:17616
data source: Reactome
xref: UnificationXref12250
xref: UnificationXref12249
cellular location: GO:0005811
comment: Reactome DB_ID: 2864097
display name: atR-PALM

UnificationXref23748
type: UnificationXref
id: 4172622
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172622

UnificationXref23745
type: UnificationXref
id: P54398
db: UniProt

UnificationXref23746
type: UnificationXref
id: 4172620
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172620

UnificationXref23743
type: UnificationXref
id: Q9I7R3
db: UniProt

UnificationXref23744
type: UnificationXref
id: 4172616
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172616

UnificationXref23742
type: UnificationXref
id: 4172612
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172612

http://identifiers.org/pubmed/9856482
type: PublicationXref
id: 9856482
author: Schnetkamp, PP
author: Tucker, JE
author: Walter, MA
author: Friedman, JS
author: Winkfein, RJ
author: Murthy, SK
author: Demetrick, DJ
db: Pubmed
title: Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger
source: Hum Genet 103:411-4
year: 1998

UnificationXref23741
type: UnificationXref
id: Q9VV47
db: UniProt

UnificationXref23740
type: UnificationXref
id: 4172608
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172608

SequenceSite11629
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11627
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11628
type: SequenceSite
position status: EQUAL
sequence position: 802

SequenceSite11625
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11626
type: SequenceSite
position status: EQUAL
sequence position: 802

SequenceSite11623
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11624
type: SequenceSite
position status: EQUAL
sequence position: 802

http://identifiers.org/pubmed/7506871
type: PublicationXref
id: 7506871
author: Hübner, S
author: Appelhans, H
author: Wagner, S
author: Drenckhahn, D
author: Kollert-Jöns, A
db: Pubmed
title: Anion exchanger 1 in human kidney and oncocytoma differs from erythroid AE1 in its NH2 terminus
source: Am J Physiol 265:F813-21
year: 1993

SequenceSite11621
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11622
type: SequenceSite
position status: EQUAL
sequence position: 802

SequenceSite11620
type: SequenceSite
position status: EQUAL
sequence position: 802

Cholecalciferol
type: SmallMolecule
entity reference: CHEBI:28940
data source: Reactome
name: Vitamin D3
xref: UnificationXref14861
xref: UnificationXref14862
cellular location: GO:0005829
comment: Reactome DB_ID: 209762
display name: VD3

UnificationXref23718
type: UnificationXref
id: REACT_24396
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24396.2

ethenocytosine
type: SmallMolecule
entity reference: CHEBI:29147
data source: Reactome
xref: UnificationXref14271
xref: UnificationXref14272
cellular location: GO:0005654
comment: Reactome DB_ID: 110233
display name: EtCYS

UnificationXref23719
type: UnificationXref
id: CHEBI:27595
db: ChEBI

2,4(1H,3H)-Pyrimidinedione, dihydro-
type: SmallMolecule
entity reference: CHEBI:15901
data source: Reactome
name: Dihydrouracile
name: 5,6-Dihydrouracil
name: 5,6-Dihydro-2,4-dihydroxypyrimidine
name: dihydrouracil
xref: UnificationXref14265
xref: UnificationXref14264
cellular location: GO:0005654
comment: Reactome DB_ID: 30140
display name: Hydrouracil

Thymine
type: SmallMolecule
entity reference: CHEBI:17821
data source: Reactome
xref: UnificationXref14247
xref: UnificationXref14248
cellular location: GO:0005654
comment: Reactome DB_ID: 29692
display name: Thy

Uracil
type: SmallMolecule
entity reference: CHEBI:17568
data source: Reactome
xref: UnificationXref14242
xref: UnificationXref14241
cellular location: GO:0005654
comment: Reactome DB_ID: 29554
display name: Ura

formamidopyrimidine
type: SmallMolecule
entity reference: CHEBI:35877
data source: Reactome
xref: UnificationXref14175
xref: UnificationXref14176
cellular location: GO:0005654
comment: Reactome DB_ID: 110228
display name: FAPY

8-oxoguanine
type: SmallMolecule
entity reference: CHEBI:44605
data source: Reactome
xref: UnificationXref14168
xref: UnificationXref14167
cellular location: GO:0005654
comment: Reactome DB_ID: 110242
display name: OGUA

SequenceSite11651
type: SequenceSite
position status: EQUAL
sequence position: 624

Pioglitazone
type: SmallMolecule
entity reference: CHEBI:8228
data source: Reactome
xref: UnificationXref13821
xref: UnificationXref13822
cellular location: GO:0005654
comment: Reactome DB_ID: 420932
display name: Actos

SequenceSite11650
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref23710
type: UnificationXref
id: 4172600
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172600

UnificationXref23711
type: UnificationXref
id: REACT_154361
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154361.3

UnificationXref23712
type: UnificationXref
id: Q9VH95
db: UniProt

UnificationXref23713
type: UnificationXref
id: 4154722
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154722

UnificationXref23714
type: UnificationXref
id: 4154724
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154724

UnificationXref23715
type: UnificationXref
id: REACT_154503
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154503.3

UnificationXref23716
type: UnificationXref
id: CHEBI:15555
db: ChEBI

UnificationXref23717
type: UnificationXref
id: 879629
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879629

cholesterol
type: SmallMolecule
entity reference: CHEBI:16113
data source: Reactome
xref: UnificationXref14877
xref: UnificationXref14876
cellular location: GO:0005758
comment: Reactome DB_ID: 196084

SequenceSite11652
type: SequenceSite
position status: EQUAL
sequence position: 1

cholesterol
type: SmallMolecule
entity reference: CHEBI:16113
data source: Reactome
xref: UnificationXref14885
xref: UnificationXref14884
cellular location: GO:0005743
comment: Reactome DB_ID: 193156

SequenceSite11653
type: SequenceSite
position status: EQUAL
sequence position: 624

SequenceSite11654
type: SequenceSite
position status: EQUAL
sequence position: 1

Calcidiol
type: SmallMolecule
entity reference: CHEBI:17933
data source: Reactome
name: 25(OH)D
name: 25-hydroxyvitamin D3
xref: UnificationXref14865
xref: UnificationXref14864
cellular location: GO:0005829
comment: Reactome DB_ID: 209804
display name: CDL

SequenceSite11655
type: SequenceSite
position status: EQUAL
sequence position: 624

http://identifiers.org/pubmed/16477006
type: PublicationXref
id: 16477006
author: Jen, KY
author: Cahir-McFarland, E
author: Kieff, E
author: Song, YJ
author: Soni, V
db: Pubmed
title: IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation
source: Proc Natl Acad Sci U S A 103:2689-94
year: 2006

SequenceSite11656
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11657
type: SequenceSite
position status: EQUAL
sequence position: 614

SequenceSite11658
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11659
type: SequenceSite
position status: EQUAL
sequence position: 614

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15422
data source: Reactome
xref: UnificationXref13053
xref: UnificationXref13054
cellular location: GO:0005576
comment: Reactome DB_ID: 114570
display name: ATP

Succinate
type: SmallMolecule
entity reference: CHEBI:15741
data source: Reactome
xref: UnificationXref12833
xref: UnificationXref12832
cellular location: GO:0005654
comment: Reactome DB_ID: 159939
display name: SUCCA

Ligands of PPARG
type: SmallMolecule
data source: Reactome
member physical entity: (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid
member physical entity: Pioglitazone
member physical entity: (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
member physical entity: Rosiglitazone
xref: UnificationXref13823
xref: UnificationXref13824
cellular location: GO:0005654
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 381235

UnificationXref23729
type: UnificationXref
id: CHEBI:15547
db: ChEBI

Heparan sulfate N-acetyl-alpha-D-glucosaminide
type: SmallMolecule
entity reference: CHEBI:17421
data source: Reactome
xref: UnificationXref13250
xref: UnificationXref13249
cellular location: GO:0005576
comment: Reactome DB_ID: 381898

alpha-ketoglutarate
type: SmallMolecule
entity reference: CHEBI:30915
data source: Reactome
name: 2-Oxoglutarate
xref: UnificationXref12825
xref: UnificationXref12826
cellular location: GO:0005654
comment: Reactome DB_ID: 113671
display name: 2OG

SequenceSite11640
type: SequenceSite
position status: EQUAL
sequence position: 2

Ethylenesuccinic acid
type: SmallMolecule
entity reference: CHEBI:15741
data source: Reactome
name: Butanedionic acid
name: Succinate
name: Succinic acid
xref: UnificationXref12798
xref: UnificationXref12799
cellular location: GO:0005829
comment: Reactome DB_ID: 29434
display name: SUCCA

CO2
type: SmallMolecule
entity reference: CHEBI:16526
data source: Reactome
xref: UnificationXref12830
xref: UnificationXref12831
cellular location: GO:0005654
comment: Reactome DB_ID: 159942

Oxygen
type: SmallMolecule
entity reference: CHEBI:15379
data source: Reactome
xref: UnificationXref12828
xref: UnificationXref12827
cellular location: GO:0005654
comment: Reactome DB_ID: 113685
display name: O2

UnificationXref23723
type: UnificationXref
id: REACT_155544
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155544.3

UnificationXref23724
type: UnificationXref
id: 2161661
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161661

UnificationXref23721
type: UnificationXref
id: REACT_150968
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150968.1

UnificationXref23722
type: UnificationXref
id: 4172580
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172580

UnificationXref23727
type: UnificationXref
id: 2142752
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142752

(9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid
type: SmallMolecule
entity reference: CHEBI:34154
data source: Reactome
xref: UnificationXref13812
xref: UnificationXref13813
cellular location: GO:0005654
comment: Reactome DB_ID: 381254
display name: 13(S')-HODE

UnificationXref23728
type: UnificationXref
id: REACT_151260
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151260.1

UnificationXref23725
type: UnificationXref
id: REACT_150622
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150622.1

UnificationXref23726
type: UnificationXref
id: CHEBI:15557
db: ChEBI

SequenceSite11649
type: SequenceSite
position status: EQUAL
sequence position: 624

UnificationXref23720
type: UnificationXref
id: 2142710
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142710

SequenceSite11643
type: SequenceSite
position status: EQUAL
sequence position: 334

SequenceSite11644
type: SequenceSite
position status: EQUAL
sequence position: 2

(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
type: SmallMolecule
entity reference: (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
data source: Reactome
name: 9(S')-HODE
xref: UnificationXref13816
xref: UnificationXref13815
cellular location: GO:0005654
comment: Reactome DB_ID: 381251
display name: 9S-HODE

SequenceSite11641
type: SequenceSite
position status: EQUAL
sequence position: 334

Rosiglitazone
type: SmallMolecule
entity reference: CHEBI:50122
data source: Reactome
xref: UnificationXref13819
xref: UnificationXref13818
cellular location: GO:0005654
comment: Reactome DB_ID: 420931
display name: RGZ

SequenceSite11642
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite11647
type: SequenceSite
position status: EQUAL
sequence position: 624

SequenceSite11648
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11645
type: SequenceSite
position status: EQUAL
sequence position: 334

SequenceSite11646
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref23777
type: UnificationXref
id: REACT_157951
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157951.3

UnificationXref23776
type: UnificationXref
id: 4175092
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175092

UnificationXref23779
type: UnificationXref
id: 265281
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265281

UnificationXref23778
type: UnificationXref
id: CHEBI:15651
db: ChEBI

NO
type: SmallMolecule
entity reference: CHEBI:16480
data source: Reactome
xref: UnificationXref14977
xref: UnificationXref14978
cellular location: GO:0005829
comment: Reactome DB_ID: 202124

SequenceSite11670
type: SequenceSite
position status: EQUAL
sequence position: 1

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Reactome
xref: UnificationXref14987
xref: UnificationXref14988
cellular location: GO:0097013
comment: Reactome DB_ID: 1470067

SequenceSite11671
type: SequenceSite
position status: EQUAL
sequence position: 337

5-alpha-dihydrotestosterone
type: SmallMolecule
entity reference: CHEBI:16330
data source: Reactome
xref: UnificationXref14963
xref: UnificationXref14964
cellular location: GO:0005829
comment: Reactome DB_ID: 469662
display name: DHTEST

SequenceSite11672
type: SequenceSite
position status: EQUAL
sequence position: 29

2-Amino-5-ureidovaleric acid
type: SmallMolecule
entity reference: CHEBI:16349
data source: Reactome
name: L-Citrulline
xref: UnificationXref14975
xref: UnificationXref14974
cellular location: GO:0005829
comment: Reactome DB_ID: 29968
display name: L-Cit

SequenceSite11673
type: SequenceSite
position status: EQUAL
sequence position: 677

Benzoquinoid ansamycins
type: SmallMolecule
data source: Reactome
member physical entity: retaspimycin hydrochloride
member physical entity: Herbimycin A
member physical entity: alvespimycin
member physical entity: 17-AAG
member physical entity: Geldanamycin
xref: UnificationXref15133
xref: UnificationXref15134
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 1217511

17-AAG
type: SmallMolecule
entity reference: CHEBI:64153
data source: Reactome
xref: UnificationXref15119
xref: UnificationXref15120
cellular location: GO:0005829
comment: Reactome DB_ID: 1217506

alvespimycin
type: SmallMolecule
entity reference: CHEBI:65324
data source: Reactome
xref: UnificationXref15123
xref: UnificationXref15122
cellular location: GO:0005829
comment: Reactome DB_ID: 1217507
display name: 17-DMAG

SequenceSite11679
type: SequenceSite
position status: EQUAL
sequence position: 91

SequenceSite11678
type: SequenceSite
position status: EQUAL
sequence position: 552

Reversible EGFR-specific tyrosine kinase inhibitors
type: SmallMolecule
data source: Reactome
member physical entity: Erlotinib
member physical entity: ZD1839
xref: UnificationXref15144
xref: UnificationXref15145
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 1176053
display name: Reversible EGFR-specific TKIs

SequenceSite11675
type: SequenceSite
position status: EQUAL
sequence position: 677

retaspimycin hydrochloride
type: SmallMolecule
entity reference: CHEBI:71956
data source: Reactome
xref: UnificationXref15131
xref: UnificationXref15132
cellular location: GO:0005829
comment: Reactome DB_ID: 1217514
display name: IPI-504

SequenceSite11674
type: SequenceSite
position status: EQUAL
sequence position: 29

Herbimycin A
type: SmallMolecule
entity reference: CHEBI:5674
data source: Reactome
xref: UnificationXref15129
xref: UnificationXref15128
cellular location: GO:0005829
comment: Reactome DB_ID: 1217510
display name: herbimycin

SequenceSite11677
type: SequenceSite
position status: EQUAL
sequence position: 37

Chromosome Maintenance
type: Pathway
data source: Reactome
pathway component: REACT 96590.9
evidence: Evidence3496
xref: UnificationXref32989
xref: UnificationXref32988
pathway order: PathwayStep3482
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Geldanamycin
type: SmallMolecule
entity reference: CHEBI:5292
data source: Reactome
xref: UnificationXref15125
xref: UnificationXref15126
cellular location: GO:0005829
comment: Reactome DB_ID: 1217505

SequenceSite11676
type: SequenceSite
position status: EQUAL
sequence position: 91

UnificationXref23772
type: UnificationXref
id: 2142797
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142797

UnificationXref23773
type: UnificationXref
id: REACT_151932
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151932.1

UnificationXref23774
type: UnificationXref
id: 4172578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172578

UnificationXref23775
type: UnificationXref
id: REACT_156231
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156231.3

UnificationXref23770
type: UnificationXref
id: REACT_150975
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150975.1

UnificationXref23771
type: UnificationXref
id: CHEBI:63977
db: ChEBI

UnificationXref23789
type: UnificationXref
id: 4154825
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154825

UnificationXref23788
type: UnificationXref
id: Q9VJ39
db: UniProt

UnificationXref23787
type: UnificationXref
id: 4154823
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154823

Isocaproic aldehyde
type: SmallMolecule
entity reference: CHEBI:17998
data source: Reactome
name: isocaproaldehyde
xref: UnificationXref14889
xref: UnificationXref14890
cellular location: GO:0005829
comment: Reactome DB_ID: 196095
display name: ISCAL

SequenceSite11661
type: SequenceSite
position status: EQUAL
sequence position: 614

isohexyl alcohol
type: SmallMolecule
entity reference: CHEBI:63910
data source: Reactome
name: 4-methylpentan-1-ol
xref: UnificationXref14893
xref: UnificationXref14892
cellular location: GO:0005829
comment: Reactome DB_ID: 196066
display name: MePeOH

SequenceSite11662
type: SequenceSite
position status: EQUAL
sequence position: 1

17alpha-hydroxypregnenolone
type: SmallMolecule
entity reference: CHEBI:28750
data source: Reactome
xref: UnificationXref14916
xref: UnificationXref14917
cellular location: GO:0005829
comment: Reactome DB_ID: 193124

pregn-5-ene-3,20-dione-17-ol
type: SmallMolecule
entity reference: CHEBI:63843
data source: Reactome
xref: UnificationXref14920
xref: UnificationXref14919
cellular location: GO:0005829
comment: Reactome DB_ID: 196366

SequenceSite11660
type: SequenceSite
position status: EQUAL
sequence position: 1

17alpha-hydroxyprogesterone
type: SmallMolecule
entity reference: CHEBI:17252
data source: Reactome
xref: UnificationXref14930
xref: UnificationXref14931
cellular location: GO:0005829
comment: Reactome DB_ID: 193092

Pregnenolone
type: SmallMolecule
entity reference: CHEBI:16581
data source: Reactome
xref: UnificationXref14937
xref: UnificationXref14938
cellular location: GO:0005829
comment: Reactome DB_ID: 193103
display name: PREG

pregn-5-ene-3,20-dione
type: SmallMolecule
entity reference: CHEBI:63837
data source: Reactome
xref: UnificationXref14941
xref: UnificationXref14940
cellular location: GO:0005829
comment: Reactome DB_ID: 196344

SequenceSite11669
type: SequenceSite
position status: EQUAL
sequence position: 401

SequenceSite11668
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11667
type: SequenceSite
position status: EQUAL
sequence position: 432

dehydroepiandrosterone
type: SmallMolecule
entity reference: CHEBI:28689
data source: Reactome
xref: UnificationXref14953
xref: UnificationXref14952
cellular location: GO:0005829
comment: Reactome DB_ID: 176626
display name: DHEA

SequenceSite11666
type: SequenceSite
position status: EQUAL
sequence position: 1

Progesterone
type: SmallMolecule
entity reference: CHEBI:17026
data source: Reactome
xref: UnificationXref14945
xref: UnificationXref14946
cellular location: GO:0005829
comment: Reactome DB_ID: 193055
display name: P4

SequenceSite11665
type: SequenceSite
position status: EQUAL
sequence position: 614

Testosterone
type: SmallMolecule
entity reference: CHEBI:17347
data source: Reactome
xref: UnificationXref14961
xref: UnificationXref14960
cellular location: GO:0005829
comment: Reactome DB_ID: 193057
display name: TES

SequenceSite11664
type: SequenceSite
position status: EQUAL
sequence position: 1

4-Androstene-3, 17-dione
type: SmallMolecule
entity reference: CHEBI:16422
data source: Reactome
xref: UnificationXref14956
xref: UnificationXref14955
cellular location: GO:0005829
comment: Reactome DB_ID: 193079

SequenceSite11663
type: SequenceSite
position status: EQUAL
sequence position: 614

UnificationXref23785
type: UnificationXref
id: REACT_3201
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3201.3

UnificationXref23786
type: UnificationXref
id: Q7KT44
db: UniProt

UnificationXref23783
type: UnificationXref
id: REACT_17747
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17747.2

UnificationXref23784
type: UnificationXref
id: 29426
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29426

http://identifiers.org/pubmed/10648409
type: PublicationXref
id: 10648409
author: Hartwig, JH
author: Barkalow, K
author: Azim, AC
author: Chou, J
db: Pubmed
title: Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor
source: Blood 95:959-64
year: 2000

UnificationXref23781
type: UnificationXref
id: CHEBI:15647
db: ChEBI

UnificationXref23782
type: UnificationXref
id: 266056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266056

UnificationXref23780
type: UnificationXref
id: REACT_15722
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15722.2

UnificationXref23755
type: UnificationXref
id: 4172631
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172631

http://identifiers.org/pubmed/20861159
type: PublicationXref
id: 20861159
author: Nilius, B
author: Colsoul, B
author: Gees, M
db: Pubmed
title: The role of transient receptor potential cation channels in Ca2+ signaling
source: Cold Spring Harb Perspect Biol 2:a003962
year: 2010

UnificationXref23754
type: UnificationXref
id: 4172630
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172630

UnificationXref23757
type: UnificationXref
id: 4172634
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172634

UnificationXref23756
type: UnificationXref
id: 4172632
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172632

UnificationXref23759
type: UnificationXref
id: 30138
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30138

UnificationXref23758
type: UnificationXref
id: REACT_156147
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156147.3

SequenceSite11690
type: SequenceSite
position status: EQUAL
sequence position: 554

SequenceSite11691
type: SequenceSite
position status: EQUAL
sequence position: 24

Dovitinib
type: SmallMolecule
entity reference: CHEBI:594834
data source: Reactome
xref: UnificationXref15299
xref: UnificationXref15298
cellular location: GO:0005829
comment: Reactome DB_ID: 1839035
display name: TKI258

SequenceSite11692
type: SequenceSite
position status: EQUAL
sequence position: 554

E3810
type: SmallMolecule
entity reference: CHEBI:65138
data source: Reactome
xref: UnificationXref15302
xref: UnificationXref15301
cellular location: GO:0005829
comment: Reactome DB_ID: 2023389

SequenceSite11693
type: SequenceSite
position status: EQUAL
sequence position: 25

Irreversible TKI inhibitor afatinib generic inhibits EGFR and ERBB2 (HER2)
type: SmallMolecule
entity reference: CHEBI:61390
data source: Reactome
name: BIBW2992
xref: UnificationXref15179
xref: UnificationXref15180
cellular location: GO:0005829
comment: Reactome DB_ID: 1220577
display name: Afatinib

SequenceSite11694
type: SequenceSite
position status: EQUAL
sequence position: -1

Tyrosine kinase inhibitors of overexpressed FGFR1
type: SmallMolecule
data source: Reactome
member physical entity: Brivanib alaninate
member physical entity: Dovitinib
member physical entity: BMS 540215
member physical entity: Cediranib
member physical entity: SU5402
member physical entity: BGJ398
member physical entity: PD173074
member physical entity: E3810
member physical entity: AZD4547
xref: UnificationXref15325
xref: UnificationXref15324
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2023441

SequenceSite11695
type: SequenceSite
position status: EQUAL
sequence position: 19

Cediranib
type: SmallMolecule
entity reference: CHEBI:556867
data source: Reactome
xref: UnificationXref15323
xref: UnificationXref15322
cellular location: GO:0005829
comment: Reactome DB_ID: 2023377
display name: AZ 2171

SequenceSite11697
type: SequenceSite
position status: EQUAL
sequence position: 19

Brivanib alaninate
type: SmallMolecule
entity reference: CHEBI:270995
data source: Reactome
xref: UnificationXref15320
xref: UnificationXref15319
cellular location: GO:0005829
comment: Reactome DB_ID: 2023387
display name: BMS 582664

SequenceSite11696
type: SequenceSite
position status: EQUAL
sequence position: 529

BMS 540215
type: SmallMolecule
entity reference: CHEBI:443041
data source: Reactome
xref: UnificationXref15316
xref: UnificationXref15317
cellular location: GO:0005829
comment: Reactome DB_ID: 2023385
display name: Brivanib

SequenceSite11699
type: SequenceSite
position status: EQUAL
sequence position: 24

SU5402
type: SmallMolecule
entity reference: CHEBI:63449
data source: Reactome
xref: UnificationXref15313
xref: UnificationXref15314
cellular location: GO:0005829
comment: Reactome DB_ID: 2054052

SequenceSite11698
type: SequenceSite
position status: EQUAL
sequence position: 529

BGJ398
type: SmallMolecule
entity reference: CHEBI:63451
data source: Reactome
xref: UnificationXref15311
xref: UnificationXref15310
cellular location: GO:0005829
comment: Reactome DB_ID: 2038925

PD173074
type: SmallMolecule
entity reference: CHEBI:63448
data source: Reactome
xref: UnificationXref15308
xref: UnificationXref15307
cellular location: GO:0005829
comment: Reactome DB_ID: 2038919

AZD4547
type: SmallMolecule
entity reference: CHEBI:63453
data source: Reactome
xref: UnificationXref15305
xref: UnificationXref15304
cellular location: GO:0005829
comment: Reactome DB_ID: 2038886

UnificationXref23750
type: UnificationXref
id: 4172626
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172626

UnificationXref23751
type: UnificationXref
id: Q9VV42
db: UniProt

UnificationXref23752
type: UnificationXref
id: 4172628
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4172628

UnificationXref23753
type: UnificationXref
id: Q8IQN8
db: UniProt

UnificationXref23768
type: UnificationXref
id: CHEBI:566274
db: ChEBI

UnificationXref23767
type: UnificationXref
id: REACT_138592
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138592.5

UnificationXref23766
type: UnificationXref
id: 4146327
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4146327

UnificationXref23765
type: UnificationXref
id: 4146325
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4146325

UnificationXref23769
type: UnificationXref
id: 2161562
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161562

Vandetanib
type: SmallMolecule
entity reference: CHEBI:49960
data source: Reactome
name: Reversible tyrosine kinase inhibitor vandetanib generic inhibits EGFR and VEGFR
name: Zactima
xref: UnificationXref15150
xref: UnificationXref15151
cellular location: GO:0005829
comment: Reactome DB_ID: 1216528
display name: ZD6474

SequenceSite11680
type: SequenceSite
position status: EQUAL
sequence position: 37

http://identifiers.org/pubmed/10574799
type: PublicationXref
id: 10574799
author: Wade, RH
author: Kozielski, F
author: De Bonis, S
author: Cohen-Addad, C
author: Burmeister, WP
db: Pubmed
title: The crystal structure of the minus-end-directed microtubule motor protein ncd reveals variable dimer conformations
source: Structure 7:1407-16
year: 1999

Erlotinib
type: SmallMolecule
entity reference: CHEBI:114785
data source: Reactome
name: OSI-774
name: Reversible tyrosine kinase inhibitor erlotinib EGFR specific
xref: UnificationXref15140
xref: UnificationXref15139
cellular location: GO:0005829
comment: Reactome DB_ID: 1173285
display name: Tarceva

SequenceSite11683
type: SequenceSite
position status: EQUAL
sequence position: 37

ZD1839
type: SmallMolecule
entity reference: CHEBI:49668
data source: Reactome
name: Reversible tyrosine kinase inhibitor gefitinib EGFR specific
name: Gefitinib
xref: UnificationXref15142
xref: UnificationXref15143
cellular location: GO:0005829
comment: Reactome DB_ID: 1169429
display name: Iressa

SequenceSite11684
type: SequenceSite
position status: EQUAL
sequence position: 552

Reversible anti-EGFRplus tyrosine kinase inhibitors
type: SmallMolecule
data source: Reactome
member physical entity: Vandetanib
member physical entity: Reversible tyrosine kinase inhibitor lapatinib generic inhibits EGFR and ERBB2 (HER2)
xref: UnificationXref15152
xref: UnificationXref15153
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 1216525
display name: Reversible anti-EGFRplus TKIs

SequenceSite11681
type: SequenceSite
position status: EQUAL
sequence position: 552

Reversible tyrosine kinase inhibitor lapatinib generic inhibits EGFR and ERBB2 (HER2)
type: SmallMolecule
entity reference: CHEBI:49603
data source: Reactome
name: Lapatinib
name: GW572016
xref: UnificationXref15148
xref: UnificationXref15147
cellular location: GO:0005829
comment: Reactome DB_ID: 1216521
display name: Tykerb

SequenceSite11682
type: SequenceSite
position status: EQUAL
sequence position: 91

Irreversible anti-EGFRplus tyrosine kinase inhibitors
type: SmallMolecule
data source: Reactome
member physical entity: Canertinib
member physical entity: Irreversible tyrosine kinase inhibitor HKI-272 generic inhibits EGFR and ERBB2 (HER2)
member physical entity: Irreversible TKI inhibitor afatinib generic inhibits EGFR and ERBB2 (HER2)
xref: UnificationXref15182
xref: UnificationXref15181
cellular location: GO:0005829
comment: Reactome DB_ID: 1216531
comment: Converted from EntitySet in Reactome
display name: Irreversible anti-EGFRplus TKIs

SequenceSite11688
type: SequenceSite
position status: EQUAL
sequence position: 530

Irreversible tyrosine kinase inhibitor WZ4002 EGFR specific
type: SmallMolecule
entity reference: CHEBI:61400
data source: Reactome
xref: UnificationXref15169
xref: UnificationXref15170
cellular location: GO:0005829
comment: Reactome DB_ID: 1227674
display name: WZ4002

SequenceSite11687
type: SequenceSite
position status: EQUAL
sequence position: 24

Canertinib
type: SmallMolecule
entity reference: CHEBI:61399
data source: Reactome
name: Irreversible TKI inhibitor canertinib generic pan-ERBB
xref: UnificationXref15177
xref: UnificationXref15178
cellular location: GO:0005829
comment: Reactome DB_ID: 1227677
display name: CI-1033

SequenceSite11686
type: SequenceSite
position status: EQUAL
sequence position: 530

Irreversible tyrosine kinase inhibitor HKI-272 generic inhibits EGFR and ERBB2 (HER2)
type: SmallMolecule
entity reference: CHEBI:61390
data source: Reactome
name: Neratinib
xref: UnificationXref15174
xref: UnificationXref15175
cellular location: GO:0005829
comment: Reactome DB_ID: 1216527
display name: HKI-272

SequenceSite11685
type: SequenceSite
position status: EQUAL
sequence position: 24

Pelitinib
type: SmallMolecule
entity reference: CHEBI:38927
data source: Reactome
name: Irreversible tyrosine kinase inhibitor pelitinib EGFR specific
xref: UnificationXref15167
xref: UnificationXref15166
cellular location: GO:0005829
comment: Reactome DB_ID: 1216524
display name: EKB-569

Irreversible EGFR-specific tyrosine kinase inhibitors
type: SmallMolecule
data source: Reactome
member physical entity: Irreversible tyrosine kinase inhibitor WZ4002 EGFR specific
member physical entity: Pelitinib
xref: UnificationXref15172
xref: UnificationXref15171
cellular location: GO:0005829
comment: Reactome DB_ID: 1216530
comment: Converted from EntitySet in Reactome
display name: Irreversible EGFR-specific TKIs

SequenceSite11689
type: SequenceSite
position status: EQUAL
sequence position: 24

UnificationXref23760
type: UnificationXref
id: REACT_3060
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3060.2

UnificationXref23763
type: UnificationXref
id: REACT_4569
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4569.2

UnificationXref23764
type: UnificationXref
id: FBpp0289404
db: Ensembl

UnificationXref23761
type: UnificationXref
id: CHEBI:15627
db: ChEBI

UnificationXref23762
type: UnificationXref
id: 32879
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=32879

UniProt:P36975
type: ProteinReference
xref: UnificationXref1028
organism: BioSource1

Stabilization of mRNA by HuR
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction309
pathway component: BiochemicalReaction307
pathway component: BiochemicalReaction308
pathway component: BiochemicalReaction306
pathway component: BiochemicalReaction305
evidence: Evidence454
xref: UnificationXref5638
xref: UnificationXref5639
pathway order: PathwayStep445
pathway order: PathwayStep446
pathway order: PathwayStep442
pathway order: PathwayStep444
pathway order: PathwayStep443
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:P36958
type: ProteinReference
xref: UnificationXref3311
organism: BioSource1

UnificationXref23793
type: UnificationXref
id: REACT_80060
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80060.9

UnificationXref23792
type: UnificationXref
id: 4154829
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154829

UnificationXref23791
type: UnificationXref
id: 4154827
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154827

UnificationXref23790
type: UnificationXref
id: 4154826
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4154826

UnificationXref23797
type: UnificationXref
id: CHEBI:28666
db: ChEBI

UnificationXref23796
type: UnificationXref
id: REACT_17252
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17252.2

UnificationXref23795
type: UnificationXref
id: 266013
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266013

UnificationXref23794
type: UnificationXref
id: CHEBI:16978
db: ChEBI

http://identifiers.org/pubmed/11389083
type: PublicationXref
id: 11389083
author: Fijan, A
author: Fehr, JL
author: Mihatsch, MJ
author: Anabitarte, M
author: Simon, R
author: Sauter, G
author: Bruderer, J
author: Gasser, T
author: Ackermann, D
author: Moch, H
author: Schmid, U
author: Maurer, R
author: Schraml, P
author: Flury, R
author: Richter, J
author: Wagner, U
author: Rist, M
author: Hardmeier, T
author: Knönagel, H
author: Wilber, K
author: Schönenberger, A
author: Hering, F
author: Jäger, P
author: Alund, G
db: Pubmed
title: High-throughput tissue microarray analysis of 3p25 (RAF1) and 8p12 (FGFR1) copy number alterations in urinary bladder cancer
source: Cancer Res 61:4514-9
year: 2001

http://identifiers.org/pubmed/16790503
type: PublicationXref
id: 16790503
author: Subramanian, VS
author: Marchant, JS
author: Said, HM
db: Pubmed
title: Biotin-responsive basal ganglia disease-linked mutations inhibit thiamine transport via hTHTR2: biotin is not a substrate for hTHTR2
source: Am J Physiol Cell Physiol 291:C851-9
year: 2006

http://identifiers.org/pubmed/12438414
type: PublicationXref
id: 12438414
author: Michael, WM
author: Van Hatten, RA
author: Holway, AH
author: Tutter, AV
author: Khederian, AM
author: Walter, JC
db: Pubmed
title: The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication.
source: J Cell Biol 159:541-7
year: 2002

UnificationXref23798
type: UnificationXref
id: 266074
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266074

UnificationXref23799
type: UnificationXref
id: REACT_15889
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15889.2

UniProt:Q9BP41
type: ProteinReference
xref: UnificationXref5336
organism: BioSource1

http://identifiers.org/pubmed/11752427
type: PublicationXref
id: 11752427
author: McCarthy, DB
author: Stoops, JK
author: O'Connor, CM
author: Reed, LJ
author: Zhou, ZH
db: Pubmed
title: The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes.
source: Proc Natl Acad Sci U S A 98:14802-7
year: 2001

Nephrin interactions
type: Pathway
data source: Reactome
pathway component: Nephrin trans-homophilic interaction
evidence: Evidence45
xref: UnificationXref651
xref: UnificationXref652
pathway order: PathwayStep42
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/9593753
type: PublicationXref
id: 9593753
author: Jackowski, S
author: Lykidis, A
author: Murti, KG
db: Pubmed
title: Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase
source: J Biol Chem 273:14022-9
year: 1998

http://identifiers.org/pubmed/10574708
type: PublicationXref
id: 10574708
author: Li, F
author: Zhang, Y
author: Wu, C
db: Pubmed
title: Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats
source: J Cell Sci 112:4589-99
year: 1999

UniProt:Q9BP35
type: ProteinReference
xref: UnificationXref22723
organism: BioSource1

UniProt:Q9BP34
type: ProteinReference
xref: UnificationXref22729
organism: BioSource1

N-glycan antennae elongation in the medial/trans-Golgi
type: Pathway
data source: Reactome
pathway component: REACT 126719.5
pathway component: REACT 127336.5
pathway component: REACT 130708.5
evidence: Evidence613
xref: UnificationXref7051
xref: UnificationXref7050
pathway order: PathwayStep596
pathway order: PathwayStep604
pathway order: PathwayStep600
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite11611
type: SequenceSite
position status: EQUAL
sequence position: 802

SequenceSite11610
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11615
type: SequenceSite
position status: EQUAL
sequence position: 550

SequenceSite11614
type: SequenceSite
position status: EQUAL
sequence position: 802

SequenceSite11613
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11612
type: SequenceSite
position status: EQUAL
sequence position: 535

SequenceSite11619
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11618
type: SequenceSite
position status: EQUAL
sequence position: 550

SequenceSite11617
type: SequenceSite
position status: EQUAL
sequence position: 802

SequenceSite11616
type: SequenceSite
position status: EQUAL
sequence position: 22

all-trans-retinol
type: SmallMolecule
entity reference: CHEBI:17336
data source: Reactome
xref: UnificationXref12117
xref: UnificationXref12116
cellular location: GO:0005886
comment: Reactome DB_ID: 975590
display name: atROL

Palmitic acid
type: SmallMolecule
entity reference: CHEBI:15756
data source: Reactome
name: Palmitate
xref: UnificationXref12120
xref: UnificationXref12119
cellular location: GO:0005886
comment: Reactome DB_ID: 426576
display name: PALM

all-trans-retinol
type: SmallMolecule
entity reference: CHEBI:17336
data source: Reactome
xref: UnificationXref12138
xref: UnificationXref12137
cellular location: GO:0005829
comment: Reactome DB_ID: 975599
display name: atROL

Beta-carotene
type: SmallMolecule
entity reference: CHEBI:17579
data source: Reactome
xref: UnificationXref12144
xref: UnificationXref12143
cellular location: GO:0005886
comment: Reactome DB_ID: 975643
display name: betaC

1,2-diacyl-glycerol 3-phosphate
type: SmallMolecule
entity reference: CHEBI:29089
data source: Reactome
xref: UnificationXref11325
xref: UnificationXref11324
cellular location: GO:0005829
comment: Reactome DB_ID: 76108
display name: Phosphatidic acid

palmitoleoyl-CoA
type: SmallMolecule
entity reference: CHEBI:53152
data source: Reactome
xref: UnificationXref11523
xref: UnificationXref11524
cellular location: GO:0005788
comment: Reactome DB_ID: 3238096

water
type: SmallMolecule
entity reference: CHEBI:15377
data source: Reactome
xref: UnificationXref12111
xref: UnificationXref12110
cellular location: GO:0005576
comment: Reactome DB_ID: 109276
display name: H2O

Retinyl palmitate
type: SmallMolecule
entity reference: CHEBI:17616
data source: Reactome
xref: UnificationXref12113
xref: UnificationXref12114
cellular location: GO:0005576
comment: Reactome DB_ID: 975591
display name: RPALM

2-Arachidonoylglycerol
type: SmallMolecule
entity reference: CHEBI:52392
data source: Reactome
name: 2-AG
xref: UnificationXref11304
xref: UnificationXref11303
cellular location: GO:0005886
comment: Reactome DB_ID: 426030
display name: 2AG

Fatty Acid
type: SmallMolecule
entity reference: CHEBI:35366
data source: Reactome
xref: UnificationXref11306
xref: UnificationXref11307
cellular location: GO:0005886
comment: Reactome DB_ID: 426026

SequenceSite11600
type: SequenceSite
position status: EQUAL
sequence position: 22

http://identifiers.org/pubmed/9124315
type: PublicationXref
id: 9124315
author: Huang, MY
author: Young, JD
author: Yao, SY
author: Ritzel, MW
author: Elliott, JF
author: Cass, CE
db: Pubmed
title: Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)
source: Am J Physiol Cell Physiol 272:707-714
year: 1997

SequenceSite11602
type: SequenceSite
position status: EQUAL
sequence position: 367

SequenceSite11601
type: SequenceSite
position status: EQUAL
sequence position: 802

SequenceSite11604
type: SequenceSite
position status: EQUAL
sequence position: 802

SequenceSite11603
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11606
type: SequenceSite
position status: EQUAL
sequence position: 802

SequenceSite11605
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11608
type: SequenceSite
position status: EQUAL
sequence position: 802

SequenceSite11607
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11609
type: SequenceSite
position status: EQUAL
sequence position: 535

http://identifiers.org/pubmed/16856888
type: PublicationXref
id: 16856888
author: Tomer, A
author: Deutsch, VR
db: Pubmed
title: Megakaryocyte development and platelet production
source: Br J Haematol 134:453-66
year: 2006

http://identifiers.org/pubmed/19010255
type: PublicationXref
id: 19010255
author: Neu-Yilik, G
author: Kulozik, AE
db: Pubmed
title: NMD: multitasking between mRNA surveillance and modulation of gene expression
source: Adv Genet 62:185-243
year: 2008

UnificationXref23391
type: UnificationXref
id: 4168454
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168454

UnificationXref23390
type: UnificationXref
id: Q9VTW2
db: UniProt

UnificationXref23393
type: UnificationXref
id: 4168457
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168457

UnificationXref23392
type: UnificationXref
id: 4168455
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168455

UnificationXref23399
type: UnificationXref
id: 4168353
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168353

cyclopropylamine
type: SmallMoleculeReference
name: cyclopropylamine [ChEBI:34660]
name: Aminocyclopropane
xref: UnificationXref28163

UnificationXref23398
type: UnificationXref
id: REACT_122466
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122466.1

UnificationXref23395
type: UnificationXref
id: 4175843
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175843

UnificationXref23394
type: UnificationXref
id: REACT_137274
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137274.5

UnificationXref23397
type: UnificationXref
id: 392417
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=392417

UnificationXref23396
type: UnificationXref
id: REACT_139721
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139721.5

debrisoquin [ChEBI:34665]
type: SmallMoleculeReference
name: Debrisochinum
name: Isocaramidine
name: debrisoquin
xref: UnificationXref27537

http://identifiers.org/pubmed/7000367
type: PublicationXref
id: 7000367
author: Kozak, M
db: Pubmed
title: Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes.
source: Cell 22:7-8
year: 1981

http://identifiers.org/pubmed/11912132
type: PublicationXref
id: 11912132
author: Lam, W
author: Jiang, Z
author: Cheng, YC
author: Dutschman, GE
author: Liou, JY
db: Pubmed
title: Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.
source: Cancer Res 62:1624-31
year: 2002

http://identifiers.org/pubmed/21602795
type: PublicationXref
id: 21602795
author: Jolly, T
author: Cardinaud, B
author: Marcet, B
author: Chevalier, B
author: Coraux, C
author: Kodjabachian, L
author: Zaragosi, LE
author: Moreilhon, C
author: Nawrocki-Raby, B
author: Giovannini-Chami, L
author: Cibois, M
author: Waldmann, R
author: Robbe-Sermesant, K
author: Birembaut, P
author: Barbry, P
author: Luxardi, G
db: Pubmed
title: Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway
source: Nat Cell Biol 13:693-9
year: 2011

http://identifiers.org/pubmed/15461586
type: PublicationXref
id: 15461586
author: Müller, S
author: Brinkmann, T
author: Prante, C
author: Schöttler, M
author: Kleesiek, K
author: Götting, C
author: Schön, S
author: Kuhn, J
db: Pubmed
title: Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity
source: Biochem J 386:227-36
year: 2005

UniProt:P18431
type: ProteinReference
xref: UnificationXref7642
organism: BioSource1

adenosine diphosphoribosyl (ADP-ribosyl) modified residue
type: SequenceModificationVocabulary
xref: UnificationXref2869

http://identifiers.org/pubmed/18395510
type: PublicationXref
id: 18395510
author: Bigotti, MG
author: Clarke, AR
db: Pubmed
title: Chaperonins: The hunt for the Group II mechanism
source: Arch Biochem Biophys 474:331-9
year: 2008

http://identifiers.org/pubmed/15591024
type: PublicationXref
id: 15591024
author: Takano, K
author: Yoshida, M
author: Asai, M
author: Oiso, Y
author: Itoi, K
author: Yamamori, E
author: Iwasaki, Y
db: Pubmed
title: Calcium/calmodulin kinase IV pathway is involved in the transcriptional regulation of the corticotropin-releasing hormone gene promoter in neuronal cells
source: J Mol Endocrinol 33:639-49
year: 2004

http://identifiers.org/pubmed/19022706
type: PublicationXref
id: 19022706
author: Moynagh, PN
db: Pubmed
title: The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling
source: Trends Immunol 30:33-42
year: 2009

3-(2-Aminoethyl)-1H-indol-5-ol
type: SmallMolecule
entity reference: CHEBI:28790
data source: Reactome
name: 5-Hydroxytryptamine
name: Enteramine
name: Serotonin
xref: UnificationXref11072
xref: UnificationXref11071
cellular location: GO:0005576
comment: Reactome DB_ID: 114523
display name: 5HT

Dopamine
type: SmallMolecule
entity reference: CHEBI:18243
data source: Reactome
xref: UnificationXref11064
xref: UnificationXref11065
cellular location: GO:0005576
comment: Reactome DB_ID: 380873
display name: DA

Phosphatidylinositol-3,4,5-trisphosphate
type: SmallMolecule
entity reference: SmallMoleculeReference192
data source: Reactome
name: PI(3,4,5)P3
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
xref: UnificationXref8203
xref: UnificationXref8204
cellular location: GO:0005886
comment: Reactome DB_ID: 179838
display name: PIP3

Mg++
type: SmallMolecule
entity reference: CHEBI:18420
data source: Reactome
name: Magnesium
xref: UnificationXref7942
xref: UnificationXref7941
cellular location: GO:0005886
comment: Reactome DB_ID: 140344
display name: Mg2+

phosphatidylinositol 1,4,5-trisphosphate
type: SmallMolecule
entity reference: CHEBI:16595
data source: Reactome
name: D-myo-Inositol 1,4,5-trisphosphate
name: I(1,4,5)P3
name: Inositol 1,4,5-trisphosphate
name: 1D-myo-Inositol 1,4,5-trisphosphate
xref: UnificationXref7920
xref: UnificationXref7921
cellular location: GO:0005829
comment: Reactome DB_ID: 114520
display name: IP3

diacylglycerols
type: SmallMolecule
entity reference: CHEBI:18035
data source: Reactome
name: DAGs
xref: UnificationXref7917
xref: UnificationXref7918
cellular location: GO:0005886
comment: Reactome DB_ID: 112275
display name: DAG

Sphingomyelin
type: SmallMolecule
entity reference: CHEBI:17636
data source: Reactome
xref: UnificationXref9571
xref: UnificationXref9572
cellular location: GO:0005829
comment: Reactome DB_ID: 194351
display name: SPHM

N-acylsphingosine
type: SmallMolecule
entity reference: CHEBI:52639
data source: Reactome
xref: UnificationXref9574
xref: UnificationXref9575
cellular location: GO:0005829
comment: Reactome DB_ID: 194377
display name: Ceramide

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Reactome
xref: UnificationXref9179
xref: UnificationXref9180
cellular location: GO:0031904
comment: Reactome DB_ID: 74722

Guanosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:17552
data source: Reactome
name: Guanosine diphosphate
xref: UnificationXref9285
xref: UnificationXref9284
cellular location: GO:0005886
comment: Reactome DB_ID: 114549
display name: GDP

Heparan Sulphate
type: SmallMolecule
entity reference: CHEBI:28815
data source: Reactome
xref: UnificationXref8503
xref: UnificationXref8504
cellular location: GO:0005576
comment: Reactome DB_ID: 190915

Phosphatidylinositol-3,4,5-trisphosphate
type: SmallMolecule
entity reference: CHEBI:16618
data source: Reactome
name: 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
xref: UnificationXref8869
xref: UnificationXref8870
cellular location: GO:0005886
comment: Reactome DB_ID: 38117
display name: PIP3

Mn(III)
type: SmallMolecule
entity reference: CHEBI:18291
data source: Reactome
name: Mn(II)
name: Manganese
xref: UnificationXref8370
xref: UnificationXref8369
cellular location: GO:0005829
comment: Reactome DB_ID: 29418
display name: Mn2+

half cystine
type: SequenceModificationVocabulary
xref: UnificationXref7193

Zn(II)
type: SmallMolecule
entity reference: CHEBI:29105
data source: Reactome
name: Zn++
name: Zinc ion
xref: UnificationXref9637
xref: UnificationXref9636
cellular location: GO:0030666
comment: Reactome DB_ID: 190019
display name: Zn2+

Choline phosphate
type: SmallMolecule
entity reference: CHEBI:18132
data source: Reactome
name: Phosphorylcholine
name: Phosphocholine
xref: UnificationXref9578
xref: UnificationXref9577
cellular location: GO:0005829
comment: Reactome DB_ID: 194358
display name: ChoP

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15996
data source: Reactome
xref: UnificationXref9643
xref: UnificationXref9642
cellular location: GO:0005768
comment: Reactome DB_ID: 190071
display name: GTP

zinc
type: SmallMolecule
entity reference: CHEBI:29105
data source: Reactome
name: Zn(II)
name: Zn++
xref: UnificationXref10732
xref: UnificationXref10733
cellular location: GO:0005886
comment: Reactome DB_ID: 109265
display name: Zn2+

O-acetylcholine
type: SmallMolecule
entity reference: CHEBI:15355
data source: Reactome
xref: UnificationXref11029
xref: UnificationXref11028
cellular location: GO:0005576
comment: Reactome DB_ID: 372533
display name: AcCho

Adrenaline and Noradrenaline
type: SmallMolecule
data source: Reactome
member physical entity: Epinephrine
member physical entity: Norepinephrine
xref: UnificationXref11045
xref: UnificationXref11044
cellular location: GO:0005576
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 400049

Epinephrine
type: SmallMolecule
entity reference: CHEBI:28918
data source: Reactome
name: Adrenaline
xref: UnificationXref11042
xref: UnificationXref11043
cellular location: GO:0005576
comment: Reactome DB_ID: 390625
display name: ADR

GDP-L-fucose
type: SmallMolecule
entity reference: CHEBI:17009
data source: Reactome
xref: UnificationXref10484
xref: UnificationXref10483
cellular location: GO:0005788
comment: Reactome DB_ID: 1463452
display name: GDP-Fuc

Guanosine 5'-Diphosphate
type: SmallMolecule
entity reference: CHEBI:17552
data source: Reactome
name: Guanosine Diphosphate
xref: UnificationXref10503
xref: UnificationXref10504
cellular location: GO:0005788
comment: Reactome DB_ID: 1467290
display name: GDP

UDPglucose
type: SmallMolecule
entity reference: CHEBI:18066
data source: Reactome
name: UDP-D-glucose
name: UDP-glucose
xref: UnificationXref10513
xref: UnificationXref10514
cellular location: GO:0005788
comment: Reactome DB_ID: 173594
display name: UDP-Glc

uridine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:17659
data source: Reactome
xref: UnificationXref10518
xref: UnificationXref10519
cellular location: GO:0005788
comment: Reactome DB_ID: 158602
display name: UDP

1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate
type: SmallMolecule
entity reference: CHEBI:18348
data source: Reactome
name: Phosphatidylinositol-4,5-bisphosphate
name: PI(4,5)P2
xref: UnificationXref7914
xref: UnificationXref7915
cellular location: GO:0005886
comment: Reactome DB_ID: 179856
display name: PIP2

NH4+
type: SmallMolecule
entity reference: CHEBI:28938
data source: Reactome
xref: UnificationXref7884
xref: UnificationXref7883
cellular location: GO:0005576
comment: Reactome DB_ID: 140912

Norepinephrine
type: SmallMolecule
entity reference: CHEBI:18357
data source: Reactome
name: Noradrenaline
xref: UnificationXref7869
xref: UnificationXref7868
cellular location: GO:0070082
comment: Reactome DB_ID: 444150
display name: NAd

Histamine
type: SmallMolecule
entity reference: CHEBI:18295
data source: Reactome
xref: UnificationXref7866
xref: UnificationXref7867
cellular location: GO:0070082
comment: Reactome DB_ID: 444149
display name: Hist

Epinephrine
type: SmallMolecule
entity reference: CHEBI:28918
data source: Reactome
name: Adrenaline
xref: UnificationXref7864
xref: UnificationXref7865
cellular location: GO:0070082
comment: Reactome DB_ID: 444148
display name: ADR

Biogenic amines transported by VMAT1/2
type: SmallMolecule
data source: Reactome
member physical entity: Dopamine
member physical entity: Epinephrine
member physical entity: Norepinephrine
member physical entity: Histamine
member physical entity: 5-Hydroxytryptamine
xref: UnificationXref7871
xref: UnificationXref7870
cellular location: GO:0070082
comment: Reactome DB_ID: 444152
comment: Converted from EntitySet in Reactome

Histamine
type: SmallMolecule
entity reference: CHEBI:18295
data source: Reactome
xref: UnificationXref7860
xref: UnificationXref7861
cellular location: GO:0005829
comment: Reactome DB_ID: 175992
display name: Hist

Biogenic amines transported by VMAT1/2
type: SmallMolecule
data source: Reactome
member physical entity: Epinephrine
member physical entity: 3-(2-Aminoethyl)-1H-indol-5-ol
member physical entity: Dopamine
member physical entity: Norepinephrine
member physical entity: Histamine
xref: UnificationXref7862
xref: UnificationXref7863
cellular location: GO:0005829
comment: Reactome DB_ID: 444154
comment: Converted from EntitySet in Reactome

Epinephrine
type: SmallMolecule
entity reference: CHEBI:28918
data source: Reactome
name: Adrenaline
xref: UnificationXref7857
xref: UnificationXref7858
cellular location: GO:0005829
comment: Reactome DB_ID: 209794
display name: ADR

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:16761
data source: Reactome
xref: UnificationXref7416
xref: UnificationXref7415
cellular location: GO:0005759
comment: Reactome DB_ID: 113581
display name: ADP

ADP
type: SmallMolecule
entity reference: CHEBI:16761
data source: Reactome
xref: UnificationXref7559
xref: UnificationXref7558
cellular location: GO:0005789
comment: Reactome DB_ID: 211606

UnificationXref23400
type: UnificationXref
id: 4168354
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168354

UnificationXref23401
type: UnificationXref
id: 4168355
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168355

UDP--N-acetylgalactosamine
type: SmallMolecule
entity reference: CHEBI:16650
data source: Reactome
xref: UnificationXref7126
xref: UnificationXref7125
cellular location: GO:0005796
comment: Reactome DB_ID: 735700
display name: UDP-GalNAc

Sialic acid
type: SmallMolecule
entity reference: CHEBI:28879
data source: Reactome
name: 9-O-acetylneuraminic acid
xref: UnificationXref7036
xref: UnificationXref7035
cellular location: GO:0005796
comment: Reactome DB_ID: 975925
display name: OANA-

Cytidine-5'-monophosphate
type: SmallMolecule
entity reference: CHEBI:17361
data source: Reactome
name: cytidine 5'-monophosphate
name: cytidylic acid
xref: UnificationXref7153
xref: UnificationXref7152
cellular location: GO:0005796
comment: Reactome DB_ID: 727810
display name: CMP

CMP-sialic acid
type: SmallMolecule
entity reference: CHEBI:16556
data source: Reactome
xref: UnificationXref7150
xref: UnificationXref7151
cellular location: GO:0005796
comment: Reactome DB_ID: 727815
display name: CMP-SA

UDP-D-galactopyranose
type: SmallMolecule
entity reference: CHEBI:18307
data source: Reactome
name: UDPgalactose
name: UDP-D-galactose
xref: UnificationXref7015
xref: UnificationXref7014
cellular location: GO:0005796
comment: Reactome DB_ID: 735682
display name: UDP-Gal

GDP-L-fucose
type: SmallMolecule
entity reference: CHEBI:17009
data source: Reactome
xref: UnificationXref6989
xref: UnificationXref6988
cellular location: GO:0005796
comment: Reactome DB_ID: 205683
display name: GDP-Fuc

GDP
type: SmallMolecule
entity reference: CHEBI:17552
data source: Reactome
xref: UnificationXref6993
xref: UnificationXref6992
cellular location: GO:0005796
comment: Reactome DB_ID: 205689

N-glycan
type: SmallMolecule
entity reference: CHEBI:59520
data source: Reactome
name: N-glycoprotein
xref: UnificationXref6947
xref: UnificationXref6948
cellular location: GO:0005796
comment: Reactome DB_ID: 975910
display name: NGP

(GlcNAc)3 (Man)3 (Asn)1
type: SmallMolecule
entity reference: CHEBI:60615
data source: Reactome
xref: UnificationXref6959
xref: UnificationXref6958
cellular location: GO:0005796
comment: Reactome DB_ID: 975819

Zinc 2+
type: SmallMolecule
entity reference: CHEBI:29105
data source: Reactome
xref: UnificationXref6962
xref: UnificationXref6961
cellular location: GO:0000139
comment: Reactome DB_ID: 975815
display name: Zn2+

(GlcNAc)4 (Man)3 (Asn)1
type: SmallMolecule
entity reference: CHEBI:60651
data source: Reactome
xref: UnificationXref6972
xref: UnificationXref6973
cellular location: GO:0005796
comment: Reactome DB_ID: 975822

UnificationXref23405
type: UnificationXref
id: 4168359
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168359

UnificationXref23404
type: UnificationXref
id: 4168358
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168358

UnificationXref23403
type: UnificationXref
id: 4168357
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168357

UnificationXref23402
type: UnificationXref
id: 4168356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168356

O-xylosyl-L-serine
type: SequenceModificationVocabulary
xref: UnificationXref16064

UnificationXref23409
type: UnificationXref
id: 4168363
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168363

O-fucosyl-L-threonine
type: SequenceModificationVocabulary
xref: UnificationXref10505

UnificationXref23408
type: UnificationXref
id: 4168362
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168362

O-fucosyl-L-serine
type: SequenceModificationVocabulary
xref: UnificationXref10506

UnificationXref23407
type: UnificationXref
id: 4168361
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168361

MPS VII - Sly syndrome
type: Pathway
data source: Reactome
pathway component: REACT 139718.5
evidence: Evidence1690
xref: UnificationXref17136
xref: UnificationXref17135
pathway order: PathwayStep1673
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref23406
type: UnificationXref
id: 4168360
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168360

UnificationXref23410
type: UnificationXref
id: 4168364
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168364

UnificationXref23411
type: UnificationXref
id: 4168365
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168365

UnificationXref23412
type: UnificationXref
id: 4168366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168366

SequenceSite11799
type: SequenceSite
position status: EQUAL
sequence position: 19

UDP
type: SmallMolecule
entity reference: CHEBI:17659
data source: Reactome
xref: UnificationXref6936
xref: UnificationXref6935
cellular location: GO:0005796
comment: Reactome DB_ID: 205687

SequenceSite11796
type: SequenceSite
position status: EQUAL
sequence position: 554

(GlcNAc)3 (Man)5 (Asn)1
type: SmallMolecule
entity reference: CHEBI:60625
data source: Reactome
xref: UnificationXref6933
xref: UnificationXref6934
cellular location: GO:0005796
comment: Reactome DB_ID: 964837

SequenceSite11795
type: SequenceSite
position status: EQUAL
sequence position: 24

UDP-N-acetylglucosamine
type: SmallMolecule
entity reference: CHEBI:16264
data source: Reactome
name: UDP-N-acetyl-D-glucosamine
xref: UnificationXref6930
xref: UnificationXref6931
cellular location: GO:0005796
comment: Reactome DB_ID: 914003
display name: UDP-GlcNAc

SequenceSite11798
type: SequenceSite
position status: EQUAL
sequence position: -1

(GlcNAc)2 (Man)7bc
type: SmallMolecule
entity reference: CHEBI:60637
data source: Reactome
xref: UnificationXref6924
xref: UnificationXref6925
cellular location: GO:0005796
comment: Reactome DB_ID: 964828

SequenceSite11797
type: SequenceSite
position status: EQUAL
sequence position: 25

(GlcNAc)2 (Man)8 (Asn)1
type: SmallMolecule
entity reference: CHEBI:59089
data source: Reactome
xref: UnificationXref6887
xref: UnificationXref6888
cellular location: GO:0005796
comment: Reactome DB_ID: 964744

SequenceSite11791
type: SequenceSite
position status: EQUAL
sequence position: 24

(GlcNAc)2 (Man)9
type: SmallMolecule
entity reference: CHEBI:59092
data source: Reactome
xref: UnificationXref6895
xref: UnificationXref6894
cellular location: GO:0005796
comment: Reactome DB_ID: 915149

SequenceSite11792
type: SequenceSite
position status: EQUAL
sequence position: 530

(Glc)3 (GlcNAc)2 (Man)9 (Asn)1
type: SmallMolecule
entity reference: CHEBI:59084
data source: Reactome
xref: UnificationXref6883
xref: UnificationXref6882
cellular location: GO:0005796
comment: Reactome DB_ID: 964754

SequenceSite11793
type: SequenceSite
position status: EQUAL
sequence position: 24

alpha-D-glucose
type: SmallMolecule
entity reference: CHEBI:17925
data source: Reactome
xref: UnificationXref6885
xref: UnificationXref6884
cellular location: GO:0005796
comment: Reactome DB_ID: 964746
display name: Glc

SequenceSite11794
type: SequenceSite
position status: EQUAL
sequence position: 554

(GlcNAc)2 (Man)8 glycans
type: SmallMolecule
data source: Reactome
member physical entity: (GlcNAc)2 (Man)8c
member physical entity: (GlcNAc)2 (Man)8a
member physical entity: (GlcNAc)2 (Man)8b
xref: UnificationXref6919
xref: UnificationXref6920
cellular location: GO:0005796
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 964831

D-mannose
type: SmallMolecule
entity reference: CHEBI:4208
data source: Reactome
xref: UnificationXref6897
xref: UnificationXref6896
cellular location: GO:0005796
comment: Reactome DB_ID: 964752
display name: Man

(GlcNAc)2 (Man)5 (Asn)1
type: SmallMolecule
entity reference: CHEBI:59087
data source: Reactome
xref: UnificationXref6900
xref: UnificationXref6899
cellular location: GO:0005796
comment: Reactome DB_ID: 964740

SequenceSite11790
type: SequenceSite
position status: EQUAL
sequence position: 530

UnificationXref23418
type: UnificationXref
id: 4168597
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168597

UnificationXref23417
type: UnificationXref
id: 4168371
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168371

3-(S-L-cysteinyl)-L-tyrosine
type: SequenceModificationVocabulary
xref: UnificationXref1714

UnificationXref23419
type: UnificationXref
id: REACT_138959
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138959.5

UnificationXref23414
type: UnificationXref
id: 4168368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168368

O-glucosyl-L-serine
type: SequenceModificationVocabulary
xref: UnificationXref10515

UnificationXref23413
type: UnificationXref
id: 4168367
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168367

UnificationXref23416
type: UnificationXref
id: 4168370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168370

UnificationXref23415
type: UnificationXref
id: 4168369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168369

UnificationXref23422
type: UnificationXref
id: 4168467
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168467

UnificationXref23423
type: UnificationXref
id: 4168539
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168539

UnificationXref23420
type: UnificationXref
id: 4168465
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168465

UnificationXref23421
type: UnificationXref
id: 4168466
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168466

UniProt:P18489
type: ProteinReference
xref: UnificationXref1041
organism: BioSource1

SequenceSite11789
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite11788
type: SequenceSite
position status: EQUAL
sequence position: 440

(GlcNAc)2 (Man)8b
type: SmallMolecule
entity reference: CHEBI:60628
data source: Reactome
xref: UnificationXref6742
xref: UnificationXref6741
cellular location: GO:0005796
comment: Reactome DB_ID: 948008

SequenceSite11787
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11786
type: SequenceSite
position status: EQUAL
sequence position: 440

(GlcNAc)2 (Man)8c
type: SmallMolecule
entity reference: CHEBI:60629
data source: Reactome
xref: UnificationXref6749
xref: UnificationXref6748
cellular location: GO:0005796
comment: Reactome DB_ID: 947996

SequenceSite11785
type: SequenceSite
position status: EQUAL
sequence position: 1

(GlcNAc)2 (Man)8a
type: SmallMolecule
entity reference: CHEBI:60627
data source: Reactome
xref: UnificationXref6746
xref: UnificationXref6745
cellular location: GO:0005796
comment: Reactome DB_ID: 948029

SequenceSite11784
type: SequenceSite
position status: EQUAL
sequence position: 2322

(GlcNAc)2 (Man)8c
type: SmallMolecule
entity reference: CHEBI:60629
data source: Reactome
xref: UnificationXref6680
xref: UnificationXref6681
cellular location: GO:0044322
comment: Reactome DB_ID: 912294

SequenceSite11782
type: SequenceSite
position status: EQUAL
sequence position: 2322

(GlcNAc)2 (Man)8a
type: SmallMolecule
entity reference: CHEBI:60627
data source: Reactome
xref: UnificationXref6687
xref: UnificationXref6686
cellular location: GO:0044322
comment: Reactome DB_ID: 912298

SequenceSite11783
type: SequenceSite
position status: EQUAL
sequence position: 30

(GlcNAc)2 (Man)7aa
type: SmallMolecule
entity reference: CHEBI:60640
data source: Reactome
xref: UnificationXref6692
xref: UnificationXref6693
cellular location: GO:0044322
comment: Reactome DB_ID: 912290

SequenceSite11780
type: SequenceSite
position status: EQUAL
sequence position: 2322

Dolichyl beta-D-glucosyl phosphate
type: SmallMolecule
entity reference: CHEBI:15812
data source: Reactome
xref: UnificationXref6698
xref: UnificationXref6697
cellular location: GO:0044322
comment: Reactome DB_ID: 912292
display name: DbGP

SequenceSite11781
type: SequenceSite
position status: EQUAL
sequence position: 30

(Glc)1 (GlcNAc)2 (Man)9
type: SmallMolecule
entity reference: CHEBI:59080
data source: Reactome
xref: UnificationXref6699
xref: UnificationXref6700
cellular location: GO:0044322
comment: Reactome DB_ID: 912286

Dolichyl phosphate
type: SmallMolecule
entity reference: CHEBI:16214
data source: Reactome
name: Dolichol phosphate
xref: UnificationXref6703
xref: UnificationXref6702
cellular location: GO:0044322
comment: Reactome DB_ID: 912287
display name: DOLP

(GlcNAc)2 (Man)8a
type: SmallMolecule
entity reference: CHEBI:60627
data source: Reactome
xref: UnificationXref6711
xref: UnificationXref6710
cellular location: GO:0005829
comment: Reactome DB_ID: 1022112

(GlcNAc)2 (Man)7aa
type: SmallMolecule
entity reference: CHEBI:60640
data source: Reactome
xref: UnificationXref6717
xref: UnificationXref6716
cellular location: GO:0005829
comment: Reactome DB_ID: 1022111

UnificationXref23429
type: UnificationXref
id: REACT_142788
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142788.5

UnificationXref23428
type: UnificationXref
id: 4168646
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168646

UnificationXref23427
type: UnificationXref
id: 4168644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168644

UnificationXref23426
type: UnificationXref
id: 4168548
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168548

UnificationXref23425
type: UnificationXref
id: 4168544
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168544

UnificationXref23424
type: UnificationXref
id: 4168543
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168543

(GlcNAc)2 (Man)8b
type: SmallMolecule
entity reference: CHEBI:60628
data source: Reactome
xref: UnificationXref6669
xref: UnificationXref6670
cellular location: GO:0044322
comment: Reactome DB_ID: 1018377

SequenceSite11773
type: SequenceSite
position status: EQUAL
sequence position: 19

D-mannose
type: SmallMolecule
entity reference: CHEBI:4208
data source: Reactome
xref: UnificationXref6674
xref: UnificationXref6673
cellular location: GO:0044322
comment: Reactome DB_ID: 912281
display name: Man

SequenceSite11774
type: SequenceSite
position status: EQUAL
sequence position: 201

SequenceSite11775
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:Q3S4X5
type: ProteinReference
xref: UnificationXref28416
organism: BioSource1

SequenceSite11776
type: SequenceSite
position status: EQUAL
sequence position: 442

SequenceSite11777
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11778
type: SequenceSite
position status: EQUAL
sequence position: 198

SequenceSite11779
type: SequenceSite
position status: EQUAL
sequence position: 30

(GlcNAc)2 (Man)9
type: SmallMolecule
entity reference: CHEBI:59092
data source: Reactome
xref: UnificationXref6665
xref: UnificationXref6666
cellular location: GO:0044322
comment: Reactome DB_ID: 912288

(Glc)1 (GlcNAc)2 (Man)9
type: SmallMolecule
entity reference: CHEBI:59080
data source: Reactome
xref: UnificationXref6623
xref: UnificationXref6624
cellular location: GO:0005788
comment: Reactome DB_ID: 532679

alpha-D-glucose
type: SmallMolecule
entity reference: CHEBI:17925
data source: Reactome
xref: UnificationXref6604
xref: UnificationXref6603
cellular location: GO:0005788
comment: Reactome DB_ID: 113780
display name: Glc

(Glc)2 (GlcNAc)2 (Man)9 (Asn)1
type: SmallMolecule
entity reference: CHEBI:59082
data source: Reactome
xref: UnificationXref6600
xref: UnificationXref6599
cellular location: GO:0005788
comment: Reactome DB_ID: 532677

(Glc)3 (GlcNAc)2 (Man)9 (Asn)1
type: SmallMolecule
entity reference: CHEBI:59084
data source: Reactome
xref: UnificationXref6594
xref: UnificationXref6595
cellular location: GO:0071556
comment: Reactome DB_ID: 532673

(Glc)3 (GlcNAc)2 (Man)9 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI:53019
data source: Reactome
xref: UnificationXref6586
xref: UnificationXref6585
cellular location: GO:0071556
comment: Reactome DB_ID: 449651

SequenceSite11770
type: SequenceSite
position status: EQUAL
sequence position: 4391

(Glc)2 (GlcNAc)2 (Man)9 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI:53020
data source: Reactome
xref: UnificationXref6579
xref: UnificationXref6578
cellular location: GO:0071556
comment: Reactome DB_ID: 449638

(Glc)1 (GlcNAc)2 (Man)9 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI:59081
data source: Reactome
xref: UnificationXref6572
xref: UnificationXref6571
cellular location: GO:0071556
comment: Reactome DB_ID: 449649

SequenceSite11772
type: SequenceSite
position status: EQUAL
sequence position: 310

Dolichyl beta-D-glucosyl phosphate
type: SmallMolecule
entity reference: CHEBI:15812
data source: Reactome
xref: UnificationXref6568
xref: UnificationXref6569
cellular location: GO:0071556
comment: Reactome DB_ID: 532542
display name: DbGP

SequenceSite11771
type: SequenceSite
position status: EQUAL
sequence position: 18

SequenceSite11764
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11765
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11762
type: SequenceSite
position status: EQUAL
sequence position: 4391

(GlcNAc)2 (Man)9 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI:59093
data source: Reactome
xref: UnificationXref6564
xref: UnificationXref6565
cellular location: GO:0071556
comment: Reactome DB_ID: 449371

SequenceSite11763
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11768
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11769
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11766
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11767
type: SequenceSite
position status: EQUAL
sequence position: 22

(GlcNAc)2 (Man)8 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI:59091
data source: Reactome
xref: UnificationXref6557
xref: UnificationXref6558
cellular location: GO:0071556
comment: Reactome DB_ID: 449365

(GlcNAc)2 (Man)7 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI:59088
data source: Reactome
xref: UnificationXref6551
xref: UnificationXref6550
cellular location: GO:0071556
comment: Reactome DB_ID: 449312

Dolichyl phosphate D-mannose
type: SmallMolecule
entity reference: CHEBI:15809
data source: Reactome
name: Dolichyl D-mannosyl phosphate
xref: UnificationXref6535
xref: UnificationXref6536
cellular location: GO:0071556
comment: Reactome DB_ID: 449229
display name: DOLPM

(GlcNAc)2 (Man)5 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI:53022
data source: Reactome
xref: UnificationXref6528
xref: UnificationXref6529
cellular location: GO:0071556
comment: Reactome DB_ID: 449298

http://identifiers.org/pubmed/12881475
type: PublicationXref
id: 12881475
author: Koesling, D
author: Friebe, A
db: Pubmed
title: Regulation of nitric oxide-sensitive guanylyl cyclase
source: Circ Res 93:96-105
year: 2003

(GlcNAc)2 (Man)6 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI:53023
data source: Reactome
xref: UnificationXref6540
xref: UnificationXref6541
cellular location: GO:0071556
comment: Reactome DB_ID: 449315

Dolichyl phosphate
type: SmallMolecule
entity reference: CHEBI:16214
data source: Reactome
name: Dolichol phosphate
xref: UnificationXref6538
xref: UnificationXref6537
cellular location: GO:0071556
comment: Reactome DB_ID: 449311
display name: DOLP

(GlcNAc)2 (Man)2 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI:59085
data source: Reactome
xref: UnificationXref6506
xref: UnificationXref6507
cellular location: GO:0071458
comment: Reactome DB_ID: 449737

SequenceSite11761
type: SequenceSite
position status: EQUAL
sequence position: 22

beta-D-mannosyldiacetylchitobiosyldiphosphodolichol
type: SmallMolecule
entity reference: CHEBI:18396
data source: Reactome
xref: UnificationXref6503
xref: UnificationXref6504
cellular location: GO:0071458
comment: Reactome DB_ID: 449283
display name: MDCDD

SequenceSite11760
type: SequenceSite
position status: EQUAL
sequence position: 4391

(GlcNAc)2 (Man)5 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI:53022
data source: Reactome
xref: UnificationXref6521
xref: UnificationXref6522
cellular location: GO:0071458
comment: Reactome DB_ID: 449332

(GlcNAc)2 (Man)3 (PP-Dol)1
type: SmallMolecule
entity reference: CHEBI:53742
data source: Reactome
xref: UnificationXref6517
xref: UnificationXref6516
cellular location: GO:0071458
comment: Reactome DB_ID: 449243

SequenceSite11755
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11756
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11757
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11758
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11751
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite11752
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite11753
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11754
type: SequenceSite
position status: EQUAL
sequence position: 4391

PublicationXref6025
type: PublicationXref
id: 12107159
author: Kung, HJ
author: Lu, TJ
author: Huang, CL
author: Hsu, CY
author: Robinson, DR
author: Wu, YM
author: Yuan, CJ
author: Lai, MD
author: Leu, TH
author: Shih, HM
author: Fang, HI
author: Huang, CY
author: Lee, WS
db: Pubmed
title: Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis
source: J Biol Chem 277:34367-74
year: 2002

UniProt:P18459
type: ProteinReference
xref: UnificationXref27072
organism: BioSource1

SequenceSite11759
type: SequenceSite
position status: EQUAL
sequence position: 22

Activation of Kainate Receptors upon glutamate binding
type: Pathway
data source: Reactome
pathway component: REACT 143784.5
pathway component: REACT 140410.5
evidence: Evidence124
xref: UnificationXref1849
xref: UnificationXref1850
pathway order: PathwayStep118
pathway order: PathwayStep116
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

N,N'-diacetylchitobiosyldiphosphodolichol
type: SmallMolecule
entity reference: CHEBI:18341
data source: Reactome
xref: UnificationXref6490
xref: UnificationXref6491
cellular location: GO:0071458
comment: Reactome DB_ID: 449293
display name: N,N'-DCDOLDP

N-acetyl-D-glucosaminyl-diphosphodolichol
type: SmallMolecule
entity reference: CHEBI:18278
data source: Reactome
xref: UnificationXref6484
xref: UnificationXref6483
cellular location: GO:0071458
comment: Reactome DB_ID: 449222
display name: GlcNAcDOLDP

Dolichyl beta-D-glucosyl phosphate
type: SmallMolecule
entity reference: CHEBI:15812
data source: Reactome
xref: UnificationXref6473
xref: UnificationXref6472
cellular location: GO:0071458
comment: Reactome DB_ID: 532214
display name: DbGP

uridine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15713
data source: Reactome
name: Uridine triphosphate
xref: UnificationXref6426
xref: UnificationXref6425
cellular location: GO:0005829
comment: Reactome DB_ID: 29494
display name: UTP

N-Acetyl-D-glucosamine 1-phosphate
type: SmallMolecule
entity reference: CHEBI:7125
data source: Reactome
xref: UnificationXref6420
xref: UnificationXref6419
cellular location: GO:0005829
comment: Reactome DB_ID: 532204
display name: AcGlcN1P

N-Acetyl-D-glucosamine 6-phosphate
type: SmallMolecule
entity reference: CHEBI:15784
data source: Reactome
xref: UnificationXref6411
xref: UnificationXref6412
cellular location: GO:0005829
comment: Reactome DB_ID: 449703
display name: AcGlcN6P

SequenceSite11750
type: SequenceSite
position status: EQUAL
sequence position: 529

UDPglucose
type: SmallMolecule
entity reference: CHEBI:18066
data source: Reactome
name: UDP-D-glucose
name: UDP-glucose
xref: UnificationXref6469
xref: UnificationXref6470
cellular location: GO:0005829
comment: Reactome DB_ID: 29410
display name: UDP-Glc

GDP-alpha-D-mannose
type: SmallMolecule
entity reference: CHEBI:15820
data source: Reactome
name: guanosine 5'-(3-(alpha-D-mannopyranosyl) dihydrogen diphosphate)
xref: UnificationXref6458
xref: UnificationXref6457
cellular location: GO:0005829
comment: Reactome DB_ID: 162860
display name: GDP-Man

D-Mannose 1-phosphate
type: SmallMolecule
entity reference: CHEBI:35374
data source: Reactome
xref: UnificationXref6448
xref: UnificationXref6449
cellular location: GO:0005829
comment: Reactome DB_ID: 532531
display name: Man1P

D-Mannose 6-phosphate
type: SmallMolecule
entity reference: CHEBI:17369
data source: Reactome
xref: UnificationXref6442
xref: UnificationXref6441
cellular location: GO:0005829
comment: Reactome DB_ID: 532562
display name: Man6P

SequenceSite11746
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite11747
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11744
type: SequenceSite
position status: EQUAL
sequence position: -1

SequenceSite11745
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11742
type: SequenceSite
position status: EQUAL
sequence position: 554

SequenceSite11743
type: SequenceSite
position status: EQUAL
sequence position: 25

http://identifiers.org/pubmed/16543383
type: PublicationXref
id: 16543383
author: Pollard, JW
author: Pollack, SE
author: Cohen, PE
db: Pubmed
title: Genetic analysis of chromosome pairing, recombination, and cell cycle control during first meiotic prophase in mammals
source: Endocr Rev 27:398-426
year: 2006

SequenceSite11740
type: SequenceSite
position status: EQUAL
sequence position: 554

SequenceSite11741
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite11748
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite11749
type: SequenceSite
position status: EQUAL
sequence position: 24

L-3-oxoalanine (Ser)
type: SequenceModificationVocabulary
xref: UnificationXref16002

UnificationXref23479
type: UnificationXref
id: 4168555
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168555

UnificationXref23473
type: UnificationXref
id: REACT_147075
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147075.5

SequenceSite11739
type: SequenceSite
position status: EQUAL
sequence position: 24

UnificationXref23474
type: UnificationXref
id: Q7KPF5
db: UniProt

SequenceSite11738
type: SequenceSite
position status: EQUAL
sequence position: 530

UnificationXref23471
type: UnificationXref
id: 4168625
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168625

SequenceSite11737
type: SequenceSite
position status: EQUAL
sequence position: 24

UnificationXref23472
type: UnificationXref
id: 4168627
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168627

UnificationXref23477
type: UnificationXref
id: 4168412
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168412

http://identifiers.org/pubmed/11278778
type: PublicationXref
id: 11278778
author: Trimble, RB
author: Cipollo, JF
author: Yan, Q
author: Dean, N
author: Chi, JH
db: Pubmed
title: The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum
source: J Biol Chem 276:21828-40
year: 2001

UnificationXref23478
type: UnificationXref
id: 4168413
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168413

PublicationXref6005
type: PublicationXref
id: 10318789
author: Wang, X
author: Widlak, P
author: Garrard, W
author: Zou, H
author: Liu, X
db: Pubmed
title: Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1
source: J Biol Chem 274:13836-40
year: 1999

UnificationXref23475
type: UnificationXref
id: 4168410
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168410

UnificationXref23476
type: UnificationXref
id: Q9VMI9
db: UniProt

SequenceSite11732
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite11731
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite11730
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite11736
type: SequenceSite
position status: EQUAL
sequence position: 530

SequenceSite11735
type: SequenceSite
position status: EQUAL
sequence position: 24

UnificationXref23470
type: UnificationXref
id: 4168381
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168381

SequenceSite11734
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite11733
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite11727
type: SequenceSite
position status: EQUAL
sequence position: 19

UnificationXref23482
type: UnificationXref
id: 4168558
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168558

SequenceSite11726
type: SequenceSite
position status: EQUAL
sequence position: 442

UnificationXref23483
type: UnificationXref
id: 4168559
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168559

SequenceSite11729
type: SequenceSite
position status: EQUAL
sequence position: 30

UnificationXref23484
type: UnificationXref
id: 4168560
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168560

SequenceSite11728
type: SequenceSite
position status: EQUAL
sequence position: 198

UnificationXref23485
type: UnificationXref
id: Q9W1Q6
db: UniProt

UnificationXref23486
type: UnificationXref
id: 4168561
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168561

UnificationXref23487
type: UnificationXref
id: Q8MLR7
db: UniProt

UnificationXref23488
type: UnificationXref
id: 4168562
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168562

UnificationXref23489
type: UnificationXref
id: Q7KK51
db: UniProt

SequenceSite11721
type: SequenceSite
position status: EQUAL
sequence position: 18

SequenceSite11720
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11723
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11722
type: SequenceSite
position status: EQUAL
sequence position: 310

SequenceSite11725
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref23480
type: UnificationXref
id: 4168556
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168556

http://identifiers.org/pubmed/10903473
type: PublicationXref
id: 10903473
author: Sprecher, H
db: Pubmed
title: Metabolism of highly unsaturated n-3 and n-6 fatty acids
source: Biochim Biophys Acta 1486:219-31
year: 2000

SequenceSite11724
type: SequenceSite
position status: EQUAL
sequence position: 201

UnificationXref23481
type: UnificationXref
id: 4168557
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168557

UnificationXref23499
type: UnificationXref
id: REACT_145733
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145733.5

UnificationXref23497
type: UnificationXref
id: 4168572
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168572

SequenceSite11719
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref23498
type: UnificationXref
id: 4168574
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168574

SequenceSite11718
type: SequenceSite
position status: EQUAL
sequence position: 4391

UnificationXref23495
type: UnificationXref
id: 4168570
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168570

SequenceSite11717
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref23496
type: UnificationXref
id: 4168571
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168571

SequenceSite11716
type: SequenceSite
position status: EQUAL
sequence position: 4391

UnificationXref23493
type: UnificationXref
id: 4168568
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168568

SequenceSite11715
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref23494
type: UnificationXref
id: Q9NDR1
db: UniProt

SequenceSite11714
type: SequenceSite
position status: EQUAL
sequence position: 4391

UnificationXref23491
type: UnificationXref
id: 4168564
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168564

SequenceSite11713
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref23492
type: UnificationXref
id: A1ZAS8
db: UniProt

SequenceSite11712
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11711
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref23490
type: UnificationXref
id: 4168563
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168563

SequenceSite11710
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11709
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11708
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11705
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11704
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11707
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11706
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11701
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite11700
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite11703
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11702
type: SequenceSite
position status: EQUAL
sequence position: 529

UnificationXref23437
type: UnificationXref
id: 4168587
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168587

UnificationXref23438
type: UnificationXref
id: 4168588
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168588

UnificationXref23435
type: UnificationXref
id: 4168585
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168585

UnificationXref23436
type: UnificationXref
id: 4168586
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168586

UnificationXref23439
type: UnificationXref
id: 4168589
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168589

UnificationXref23430
type: UnificationXref
id: 4168580
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168580

UnificationXref23434
type: UnificationXref
id: 4168584
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168584

UnificationXref23433
type: UnificationXref
id: 4168583
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168583

UnificationXref23432
type: UnificationXref
id: 4168582
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168582

UnificationXref23431
type: UnificationXref
id: 4168581
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168581

UnificationXref23446
type: UnificationXref
id: 4168373
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168373

UnificationXref23447
type: UnificationXref
id: REACT_138985
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138985.5

UnificationXref23448
type: UnificationXref
id: 4168550
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168550

UnificationXref23449
type: UnificationXref
id: REACT_139065
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139065.5

Purine ribonucleoside monophosphate biosynthesis
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction1777
pathway component: BiochemicalReaction1778
pathway component: BiochemicalReaction1772
pathway component: BiochemicalReaction1764
pathway component: BiochemicalReaction1776
pathway component: BiochemicalReaction1775
pathway component: BiochemicalReaction1779
pathway component: BiochemicalReaction1769
pathway component: BiochemicalReaction1774
pathway component: BiochemicalReaction1767
pathway component: BiochemicalReaction1773
pathway component: BiochemicalReaction1770
pathway component: BiochemicalReaction1771
pathway component: BiochemicalReaction1766
pathway component: BiochemicalReaction1768
pathway component: BiochemicalReaction1765
evidence: Evidence2610
xref: UnificationXref25162
xref: RelationshipXref1593
xref: UnificationXref25163
pathway order: PathwayStep2592
pathway order: PathwayStep2600
pathway order: PathwayStep2604
pathway order: PathwayStep2601
pathway order: PathwayStep2596
pathway order: PathwayStep2590
pathway order: PathwayStep2602
pathway order: PathwayStep2595
pathway order: PathwayStep2593
pathway order: PathwayStep2591
pathway order: PathwayStep2597
pathway order: PathwayStep2594
pathway order: PathwayStep2599
pathway order: PathwayStep2598
pathway order: PathwayStep2589
pathway order: PathwayStep2603
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10371034
type: PublicationXref
id: 10371034
author: Rüegsegger, U
author: Wahle, E
db: Pubmed
title: 3'-End processing of pre-mRNA in eukaryotes.
source: FEMS Microbiol Rev 23:277-95
year: 1999

UnificationXref23441
type: UnificationXref
id: 4168591
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168591

UnificationXref23440
type: UnificationXref
id: 4168590
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168590

UnificationXref23443
type: UnificationXref
id: REACT_128407
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128407.5

UnificationXref23442
type: UnificationXref
id: 4168593
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168593

UnificationXref23445
type: UnificationXref
id: REACT_12881
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_12881.1

UnificationXref23444
type: UnificationXref
id: 202247
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=202247

UnificationXref23459
type: UnificationXref
id: 4168609
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168609

UnificationXref23457
type: UnificationXref
id: 4168606
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168606

UnificationXref23458
type: UnificationXref
id: 4168607
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168607

http://identifiers.org/pubmed/14671330
type: PublicationXref
id: 14671330
author: McRee, DE
author: Ribas de Pouplana, L
author: Otero, FJ
author: Yang, XL
author: Schimmel, P
author: Skene, RJ
db: Pubmed
title: Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
source: Proc Natl Acad Sci U S A 100:15376-80
year: 2003

UnificationXref23456
type: UnificationXref
id: 4168605
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168605

UnificationXref23455
type: UnificationXref
id: 4168604
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168604

UnificationXref23454
type: UnificationXref
id: 4168603
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168603

UnificationXref23453
type: UnificationXref
id: 4168602
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168602

UnificationXref23452
type: UnificationXref
id: 4168601
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168601

UnificationXref23451
type: UnificationXref
id: REACT_122314
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122314.1

http://identifiers.org/pubmed/21540551
type: PublicationXref
id: 21540551
author: Matejas, V
author: Kispert, A
author: Casarin, A
author: Faul, C
author: Pertegato, V
author: Akman, S
author: Kusakabe, T
author: Wang, S
author: Santos-Ocaña, C
author: Krick, S
author: Doimo, M
author: Hildebrandt, F
author: Chernin, G
author: Vega-Warner, V
author: McLaughlin, HM
author: Nürnberg, G
author: Navas, P
author: Chaki, M
author: Schoeb, DS
author: Becker, C
author: Saisawat, P
author: Heeringa, SF
author: Varpizen, S
author: Prokisch, H
author: Wiggins, RC
author: Nürnberg, P
author: Beissert, A
author: Zhou, W
author: Bakkaloglu, A
author: Ji, Z
author: Xie, LX
author: Hinkes, B
author: Bakkaloglu, SA
author: Salviati, L
author: Reiser, J
author: Vlangos, CN
author: Mir, S
author: Airik, R
author: Topaloglu, R
author: Sloan, AJ
author: Rötig, A
author: Trevisson, E
author: Gbadegesin, R
author: Raphael, Y
author: Zenker, M
author: Clarke, CF
author: Ozaltin, F
author: Soliman, NA
author: Müller, D
author: Berdeli, A
author: Ashraf, S
author: Killen, PD
author: Mundel, P
author: Hurd, TW
author: Giorgi, G
author: Ovunc, B
db: Pubmed
title: COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness
source: J Clin Invest 121:2013-24
year: 2011

UnificationXref23450
type: UnificationXref
id: 1604565
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1604565

http://identifiers.org/pubmed/12855817
type: PublicationXref
id: 12855817
author: Sato, S
author: Takeda, K
author: Takeuchi, O
author: Sanjo, H
author: Sugiyama, M
author: Hoshino, K
author: Kaisho, T
author: Hemmi, H
author: Okabe, M
author: Yamamoto, M
db: Pubmed
title: Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
source: Science 301:640-3
year: 2003

UnificationXref23468
type: UnificationXref
id: 4168379
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168379

UnificationXref23469
type: UnificationXref
id: 4168380
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168380

UnificationXref23465
type: UnificationXref
id: Q8SXX1
db: UniProt

UnificationXref23464
type: UnificationXref
id: REACT_121667
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121667.1

UnificationXref23467
type: UnificationXref
id: 4168378
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168378

UnificationXref23466
type: UnificationXref
id: 4168377
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168377

UnificationXref23461
type: UnificationXref
id: 4168629
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168629

UnificationXref23460
type: UnificationXref
id: REACT_144879
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144879.5

UnificationXref23463
type: UnificationXref
id: 1806276
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806276

UnificationXref23462
type: UnificationXref
id: REACT_143108
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143108.5

http://identifiers.org/pubmed/9536089
type: PublicationXref
id: 9536089
author: Hogenhout, EM
author: Muijsers, AO
author: Caruso, U
author: Ofman, R
author: Hettema, EH
author: Wanders, RJ
db: Pubmed
title: Acyl-CoA:dihydroxyacetonephosphate acyltransferase: cloning of the human cDNA and resolution of the molecular basis in rhizomelic chondrodysplasia punctata type 2
source: Hum Mol Genet 7:847-53
year: 1998

http://identifiers.org/pubmed/18087715
type: PublicationXref
id: 18087715
author: Zhang, H
author: Jia, Q
author: Liu, B
author: Zhao, Z
author: Zhang, G
author: Jia, Z
author: Geng, X
db: Pubmed
title: Molecular basis for genistein-induced inhibition of Kir2.3 currents
source: Pflugers Arch 456:413-23
year: 2008

http://identifiers.org/pubmed/16012724
type: PublicationXref
id: 16012724
author: Leoni, VP
author: Giovanazzi, R
author: Ravagnani, F
author: Signoroni, S
author: Dragani, TA
author: Frattini, M
author: Tanuma, J
author: Spinola, M
author: Bertario, L
author: Pettinicchio, A
author: Agresti, R
author: Pilotti, S
db: Pubmed
title: FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer
source: Oncol Rep 14:415-9
year: 2005

http://identifiers.org/pubmed/19926846
type: PublicationXref
id: 19926846
author: Saitoh, T
author: Hayashi, Takuya
author: Matsunaga, Kohichi
author: Lee, Hanna
author: Satoh, T
author: Akira, S
author: Takeuchi, O
author: Noda, Takeshi
author: Ishii, Ken
author: Fujita, Naonobu
author: Kageyama, Shun
author: Takahara, Keigo
author: Omori, Hiroko
author: Kawai, T
author: Yamamoto, Naoki
author: Yoshimori, Tamotsu
db: Pubmed
title: Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
source: Proc. Natl. Acad. Sci. U.S.A. 106:20842-6
year: 2009

http://identifiers.org/pubmed/8033208
type: PublicationXref
id: 8033208
author: Shirodkar, S
author: Kaelin WG, Jr
author: Livingston, DM
author: Ewen, ME
author: Krek, W
author: Arany, Z
db: Pubmed
title: Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
source: Cell 78:161-72
year: 1994

http://identifiers.org/pubmed/12648452
type: PublicationXref
id: 12648452
author: Buttgereit, F
author: Qian, SB
author: Finzi, D
author: Princiotta, MF
author: Yewdell, JW
author: Gibbs, J
author: Bennink, JR
author: Schuchmann, S
db: Pubmed
title: Quantitating protein synthesis, degradation, and endogenous antigen processing
source: Immunity 18:343-54
year: 2003

Alcohol catabolism
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction2019
pathway component: BiochemicalReaction2018
pathway component: BiochemicalReaction2020
evidence: Evidence2910
xref: RelationshipXref1999
xref: UnificationXref27619
xref: UnificationXref27618
pathway order: PathwayStep2904
pathway order: PathwayStep2903
pathway order: PathwayStep2902
display name: Ethanol oxidation
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/17371050
type: PublicationXref
id: 17371050
author: Kondo, N
author: Fukao, T
author: Haapalainen, AM
author: Wierenga, RK
author: Meriläinen, G
author: Pirilä, PL
db: Pubmed
title: Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function
source: Biochemistry 46:4305-21
year: 2007

http://identifiers.org/pubmed/17726575
type: PublicationXref
id: 17726575
author: Robinson, PR
author: Nickle, B
db: Pubmed
title: The opsins of the vertebrate retina: insights from structural, biochemical, and evolutionary studies
source: Cell Mol Life Sci 64:2917-32
year: 2007

FGFR1c ligand binding and activation
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction508
pathway component: BiochemicalReaction509
evidence: Evidence789
xref: UnificationXref8541
xref: UnificationXref8542
xref: RelationshipXref460
pathway order: PathwayStep775
pathway order: PathwayStep776
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/7816143
type: PublicationXref
id: 7816143
author: Glover, JN
author: Harrison, SC
db: Pubmed
title: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA
source: Nature 373:257-61
year: 1995

D-glucosamine 6-phosphate
type: SmallMolecule
entity reference: CHEBI:15873
data source: Reactome
xref: UnificationXref6367
xref: UnificationXref6368
cellular location: GO:0005829
comment: Reactome DB_ID: 449701
display name: GlcN6P

http://identifiers.org/pubmed/13416257
type: PublicationXref
id: 13416257
author: Robinson, WG
author: Coon, MJ
db: Pubmed
title: Purification and properties of beta-hydroxyisobutyric dehydrogenase
source: J Biol Chem 225:511-521
year: 1957

UniProt:P00334
type: ProteinReference
xref: UnificationXref23749
organism: BioSource1

http://identifiers.org/pubmed/14765176
type: PublicationXref
id: 14765176
author: Sadler, JE
db: Pubmed
title: Medicine: K is for koagulation
source: Nature 427:493-4
year: 2004

http://identifiers.org/pubmed/14765195
type: PublicationXref
id: 14765195
author: Chang, CY
author: Stafford, DW
author: Lin, PJ
author: Li, T
author: Jin, DY
author: Khvorova, A
db: Pubmed
title: Identification of the gene for vitamin K epoxide reductase
source: Nature 427:541-4
year: 2004

http://identifiers.org/pubmed/14765194
type: PublicationXref
id: 14765194
author: Muller, CR
author: Hortnagel, K
author: Strom, TM
author: Seifried, E
author: Scharrer, I
author: Rost, S
author: Pelz, HJ
author: Oldenburg, J
author: Fregin, A
author: Conzelmann, E
author: Lappegard, K
author: Ivaskevicius, V
author: Tuddenham, EG
db: Pubmed
title: Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
source: Nature 427:537-41
year: 2004

Guanosine monophosphate
type: SmallMolecule
entity reference: CHEBI:17345
data source: Reactome
name: Guanosine 5'-phosphate
name: Guanylic acid
name: Guanosine 5'-monophosphate
xref: UnificationXref5075
xref: UnificationXref5074
cellular location: GO:0005829
comment: Reactome DB_ID: 113578
display name: GMP

uridine 5'-monophosphate
type: SmallMolecule
entity reference: CHEBI:16695
data source: Reactome
name: Uridine monophosphate
name: uridylic acid
name: 5'Uridylic acid
xref: UnificationXref5073
xref: UnificationXref5072
cellular location: GO:0005829
comment: Reactome DB_ID: 109402
display name: UMP

Cytidine-5'-monophosphate
type: SmallMolecule
entity reference: CHEBI:17361
data source: Reactome
name: cytidine 5'-monophosphate
name: cytidylic acid
xref: UnificationXref5069
xref: UnificationXref5070
cellular location: GO:0005829
comment: Reactome DB_ID: 109395
display name: CMP

Tyr-tRNA(Tyr)
type: SmallMolecule
entity reference: CHEBI:29161
data source: Reactome
xref: UnificationXref5013
xref: UnificationXref5012
cellular location: GO:0005759
comment: Reactome DB_ID: 379755

tRNA(Tyr)
type: SmallMolecule
entity reference: CHEBI:29182
data source: Reactome
xref: UnificationXref5010
xref: UnificationXref5011
cellular location: GO:0005759
comment: Reactome DB_ID: 379756

Aminoacyl-tRNA
type: SmallMolecule
data source: Reactome
member physical entity: Tyr-tRNA(Tyr)
member physical entity: Thr-tRNA(Thr)
member physical entity: Ile-tRNA(Ile)
member physical entity: Pro-tRNA(Pro)
member physical entity: Asn-tRNA(Asn)
member physical entity: Val-tRNA(Val)
member physical entity: Ser-tRNA(Ser)
member physical entity: Ala-tRNA(Ala)
member physical entity: Asp-tRNA(Asp)
member physical entity: Met-tRNA(Met)
member physical entity: Glu-tRNA(Glu)
member physical entity: Gly-tRNA(Gly)
member physical entity: Gln-tRNA(Gln)
member physical entity: Cys-tRNA(Cys)
member physical entity: Phe-tRNA(Phe)
member physical entity: Arg-tRNA(Arg)
member physical entity: Trp-tRNA(Trp)
member physical entity: Leu-tRNA(Leu)
member physical entity: His-tRNA(His)
member physical entity: Lys-tRNA(Lys)
xref: UnificationXref5886
xref: UnificationXref5887
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 37001

7-methylguanosine cap
type: SmallMolecule
entity reference: SmallMoleculeReference115
data source: Reactome
xref: UnificationXref5944
xref: UnificationXref5945
cellular location: GO:0005654
comment: Reactome DB_ID: 192865
display name: m7G cap

transfer RNA
type: SmallMolecule
entity reference: CHEBI:17843
data source: Reactome
xref: UnificationXref5230
xref: UnificationXref5229
cellular location: GO:0005829
comment: Reactome DB_ID: 141679
display name: tRNA

Guanosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:17552
data source: Reactome
name: Guanosine diphosphate
xref: UnificationXref5263
xref: UnificationXref5262
cellular location: GO:0005829
comment: Reactome DB_ID: 29420
display name: GDP

7-methylguanosine 5'-monophosphate
type: SmallMolecule
entity reference: CHEBI:17825
data source: Reactome
xref: UnificationXref5121
xref: UnificationXref5122
cellular location: GO:0005829
comment: Reactome DB_ID: 430042
display name: 7-MeGMP

7-methylguanosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:20794
data source: Reactome
xref: UnificationXref5182
xref: UnificationXref5181
cellular location: GO:0005829
comment: Reactome DB_ID: 430004
display name: 7-MeGDP

vitamin K epoxide
type: SmallMolecule
entity reference: CHEBI:28371
data source: Reactome
xref: UnificationXref6118
xref: UnificationXref6117
cellular location: GO:0005788
comment: Reactome DB_ID: 159835
display name: VKO

7-methylguanosine cap
type: SmallMolecule
entity reference: CHEBI:2274
data source: Reactome
xref: UnificationXref5957
xref: UnificationXref5956
cellular location: GO:0005829
comment: Reactome DB_ID: 191889
display name: m7G cap

vitamin K hydroquinone
type: SmallMolecule
entity reference: CHEBI:28433
data source: Reactome
xref: UnificationXref6123
xref: UnificationXref6122
cellular location: GO:0005788
comment: Reactome DB_ID: 159853
display name: VKHQ

H+
type: SmallMolecule
entity reference: CHEBI:15378
data source: Reactome
xref: UnificationXref6120
xref: UnificationXref6119
cellular location: GO:0005788
comment: Reactome DB_ID: 156540

1,3-diaminopropane
type: SmallMolecule
entity reference: CHEBI:15725
data source: Reactome
xref: UnificationXref6151
xref: UnificationXref6152
cellular location: GO:0005829
comment: Reactome DB_ID: 204628

Oxygen
type: SmallMolecule
entity reference: CHEBI:15379
data source: Reactome
xref: UnificationXref6162
xref: UnificationXref6161
cellular location: GO:0005829
comment: Reactome DB_ID: 29368
display name: O2

Fe(III)
type: SmallMolecule
entity reference: CHEBI:18248
data source: Reactome
name: iron (ferrous)
name: Fe3+
name: Fe(II)
name: Iron
name: Fe++
xref: UnificationXref6169
xref: UnificationXref6168
cellular location: GO:0005829
comment: Reactome DB_ID: 71067
display name: Fe2+

1-Phosphatidyl-D-myo-inositol
type: SmallMolecule
entity reference: CHEBI:16749
data source: Reactome
name: phosphatidylinositol
xref: UnificationXref6180
xref: UnificationXref6181
cellular location: GO:0005789
comment: Reactome DB_ID: 162339
display name: PI

DPN
type: SmallMolecule
entity reference: CHEBI:15846
data source: Reactome
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref6135
xref: UnificationXref6136
cellular location: GO:0005829
comment: Reactome DB_ID: 29360
display name: NAD

Spermidine
type: SmallMolecule
entity reference: CHEBI:16610
data source: Reactome
xref: UnificationXref6143
xref: UnificationXref6142
cellular location: GO:0005829
comment: Reactome DB_ID: 204635
display name: SPM

NADH
type: SmallMolecule
entity reference: CHEBI:16908
data source: Reactome
xref: UnificationXref6148
xref: UnificationXref6149
cellular location: GO:0005829
comment: Reactome DB_ID: 73473

http://identifiers.org/pubmed/17891149
type: PublicationXref
id: 17891149
author: Fasshauer, D
author: Riedel, D
author: Jahn, R
author: Radhakrishnan, A
author: Stein, A
db: Pubmed
title: Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids
source: Nat Struct Mol Biol 14:904-11
year: 2007

uridine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:17659
data source: Reactome
xref: UnificationXref6189
xref: UnificationXref6190
cellular location: GO:0005829
comment: Reactome DB_ID: 110096
display name: UDP

N-acetylglucosaminyl-PI
type: SmallMolecule
entity reference: CHEBI:15935
data source: Reactome
name: N-acetyl-D-glucosaminylphosphatidylinositol
xref: UnificationXref6186
xref: UnificationXref6187
cellular location: GO:0005789
comment: Reactome DB_ID: 162341
display name: GlcNAc-PI

UDP-N-acetylglucosamine
type: SmallMolecule
entity reference: CHEBI:16264
data source: Reactome
name: UDP-N-acetyl-D-glucosamine
xref: UnificationXref6183
xref: UnificationXref6184
cellular location: GO:0005829
comment: Reactome DB_ID: 162756
display name: UDP-AcGlcN

Fatty acyl CoA
type: SmallMolecule
entity reference: CHEBI:37554
data source: Reactome
xref: UnificationXref6228
xref: UnificationXref6227
cellular location: GO:0005788
comment: Reactome DB_ID: 162768
display name: acyl-CoA

glucosaminyl-acyl-PI
type: SmallMolecule
entity reference: CHEBI:52572
data source: Reactome
xref: UnificationXref6231
xref: UnificationXref6230
cellular location: GO:0005789
comment: Reactome DB_ID: 162856
display name: GlcN-acyl-PI

Acetate
type: SmallMolecule
entity reference: CHEBI:15366
data source: Reactome
name: Ethanoic acid
name: Acetic acid
xref: UnificationXref6213
xref: UnificationXref6212
cellular location: GO:0005829
comment: Reactome DB_ID: 29416
display name: CH3COO-

UniProt:P18502
type: ProteinReference
xref: UnificationXref11148
organism: BioSource1

glucosaminyl-PI
type: SmallMolecule
entity reference: CHEBI:24275
data source: Reactome
xref: UnificationXref6215
xref: UnificationXref6216
cellular location: GO:0005789
comment: Reactome DB_ID: 162839
display name: GlcN-PI

mannose (a1-4) glucosaminyl-acyl-PI
type: SmallMolecule
entity reference: CHEBI:53056
data source: Reactome
xref: UnificationXref6247
xref: UnificationXref6246
cellular location: GO:0005789
comment: Reactome DB_ID: 162793

dolichyl phosphate
type: SmallMolecule
entity reference: CHEBI:16214
data source: Reactome
xref: UnificationXref6250
xref: UnificationXref6249
cellular location: GO:0005789
comment: Reactome DB_ID: 162872

CoA-SH
type: SmallMolecule
entity reference: CHEBI:15346
data source: Reactome
xref: UnificationXref6232
xref: UnificationXref6233
cellular location: GO:0005788
comment: Reactome DB_ID: 162743

dolichyl phosphate D-mannose
type: SmallMolecule
entity reference: SmallMoleculeReference131
data source: Reactome
name: dolichyl D-mannosyl phosphate
xref: UnificationXref6244
xref: UnificationXref6243
cellular location: GO:0071458
comment: Reactome DB_ID: 162681
display name: DOLPman

1,2-Diacylglyceroll
type: SmallMolecule
entity reference: SmallMoleculeReference57
data source: Reactome
xref: UnificationXref6268
xref: UnificationXref6269
cellular location: GO:0005789
comment: Reactome DB_ID: 162777
display name: DAG

phosphatidylethanolamine
type: SmallMolecule
entity reference: SmallMoleculeReference134
data source: Reactome
xref: UnificationXref6267
xref: UnificationXref6266
cellular location: GO:0005789
comment: Reactome DB_ID: 162803
display name: PE

http://identifiers.org/pubmed/19501527
type: PublicationXref
id: 19501527
author: Cassel, SL
author: Sutterwala, FS
author: Joly, S
db: Pubmed
title: The NLRP3 inflammasome: a sensor of immune danger signals
source: Semin Immunol 21:194-8
year: 2009

mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI
type: SmallMolecule
entity reference: CHEBI:53058
data source: Reactome
xref: UnificationXref6298
xref: UnificationXref6299
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 162848

http://identifiers.org/pubmed/8535439
type: PublicationXref
id: 8535439
author: Tolan, DR
db: Pubmed
title: Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene
source: Hum Mutat 6:210-8
year: 1995

mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI
type: SmallMolecule
entity reference: CHEBI:53059
data source: Reactome
xref: UnificationXref6305
xref: UnificationXref6306
cellular location: GO:0005789
comment: Reactome DB_ID: 162684

(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI
type: SmallMolecule
entity reference: SmallMoleculeReference137
data source: Reactome
xref: UnificationXref6312
xref: UnificationXref6313
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 162704
display name: acyl-GPI

(ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI
type: SmallMolecule
entity reference: SmallMoleculeReference138
data source: Reactome
xref: UnificationXref6329
xref: UnificationXref6328
cellular location: GO:0005789
comment: Reactome DB_ID: 162799

cytidine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:17677
data source: Reactome
name: Cytidine triphosphate
xref: UnificationXref6342
xref: UnificationXref6343
cellular location: GO:0005829
comment: Reactome DB_ID: 110614
display name: CTP

Dolichol
type: SmallMolecule
entity reference: CHEBI:16091
data source: Reactome
xref: UnificationXref6345
xref: UnificationXref6346
cellular location: GO:0071458
comment: Reactome DB_ID: 449221

Cytidine diphosphate
type: SmallMolecule
entity reference: CHEBI:17239
data source: Reactome
name: cytidine 5'-diphosphate
xref: UnificationXref6348
xref: UnificationXref6349
cellular location: GO:0005829
comment: Reactome DB_ID: 110094
display name: CDP

Dolichyl phosphate
type: SmallMolecule
entity reference: CHEBI:16214
data source: Reactome
name: Dolichol phosphate
xref: UnificationXref6350
xref: UnificationXref6351
cellular location: GO:0071458
comment: Reactome DB_ID: 449299
display name: DOLP

D-Fructose 6-phosphoric acid
type: SmallMolecule
entity reference: CHEBI:15946
data source: Reactome
name: D-Fructose 6-phosphate
name: Neuberg ester
xref: UnificationXref6365
xref: UnificationXref6364
cellular location: GO:0005829
comment: Reactome DB_ID: 29512
display name: Fru(6)P

http://identifiers.org/pubmed/12077706
type: PublicationXref
id: 12077706
author: Vadalà , M
author: Lorenz, B
author: Rosenberg, T
author: Kellner, U
author: Kohl, S
author: Jacobson, SG
author: Wissinger, B
author: Baumann, B
db: Pubmed
title: Mutations in the cone photoreceptor G-protein alpha-subunit gene GNAT2 in patients with achromatopsia
source: Am J Hum Genet 71:422-5
year: 2002

Leu-tRNA(Leu)
type: SmallMolecule
entity reference: CHEBI:16624
data source: Reactome
xref: UnificationXref4918
xref: UnificationXref4917
cellular location: GO:0005759
comment: Reactome DB_ID: 379773

L-Leucine
type: SmallMolecule
entity reference: CHEBI:15603
data source: Reactome
name: (2S)-alpha-2-Amino-4-methylvaleric acid
name: (2S)-alpha-Leucine
name: 2-amino-4-methylvaleric acid
xref: UnificationXref4915
xref: UnificationXref4916
cellular location: GO:0005759
comment: Reactome DB_ID: 113580
display name: L-Leu

tRNA(Leu)
type: SmallMolecule
entity reference: CHEBI:29169
data source: Reactome
xref: UnificationXref4914
xref: UnificationXref4913
cellular location: GO:0005759
comment: Reactome DB_ID: 379788

UnificationXref23530
type: UnificationXref
id: 4168636
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168636

UnificationXref23531
type: UnificationXref
id: 4168637
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168637

UnificationXref23532
type: UnificationXref
id: 4168638
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168638

UnificationXref23533
type: UnificationXref
id: 4168635
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168635

UnificationXref23539
type: UnificationXref
id: 1806259
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806259

UnificationXref23538
type: UnificationXref
id: REACT_128946
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128946.5

UnificationXref23535
type: UnificationXref
id: 4168641
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168641

UnificationXref23534
type: UnificationXref
id: 4168639
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168639

UnificationXref23537
type: UnificationXref
id: 4168643
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168643

UnificationXref23536
type: UnificationXref
id: REACT_134200
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134200.5

tRNA(His)
type: SmallMolecule
entity reference: CHEBI:29178
data source: Reactome
xref: UnificationXref4890
xref: UnificationXref4891
cellular location: GO:0005759
comment: Reactome DB_ID: 379752

(S)-alpha-Amino-1H-imidazole-4-propionic acid
type: SmallMolecule
entity reference: CHEBI:15971
data source: Reactome
name: L-Histidine
xref: UnificationXref4892
xref: UnificationXref162
cellular location: GO:0005759
comment: Reactome DB_ID: 379695
display name: L-His

Glycine
type: SmallMolecule
entity reference: CHEBI:15428
data source: Reactome
name: Aminoacetic acid
xref: UnificationXref4880
xref: UnificationXref4879
cellular location: GO:0005759
comment: Reactome DB_ID: 159549
display name: Gly

Gly-tRNA(Gly)
type: SmallMolecule
entity reference: CHEBI:29156
data source: Reactome
xref: UnificationXref4882
xref: UnificationXref4881
cellular location: GO:0005759
comment: Reactome DB_ID: 379781

L-Isoleucine
type: SmallMolecule
entity reference: CHEBI:17191
data source: Reactome
name: 2-Amino-3-methylvaleric acid
xref: UnificationXref4902
xref: UnificationXref4903
cellular location: GO:0005759
comment: Reactome DB_ID: 113537
display name: L-Ile

Ile-tRNA(Ile)
type: SmallMolecule
entity reference: CHEBI:29160
data source: Reactome
xref: UnificationXref4904
xref: UnificationXref4905
cellular location: GO:0005759
comment: Reactome DB_ID: 379769

His-tRNA(His)
type: SmallMolecule
entity reference: CHEBI:29155
data source: Reactome
xref: UnificationXref4893
xref: UnificationXref4894
cellular location: GO:0005759
comment: Reactome DB_ID: 379764

tRNA(Ile)
type: SmallMolecule
entity reference: CHEBI:29174
data source: Reactome
xref: UnificationXref4901
xref: UnificationXref4900
cellular location: GO:0005759
comment: Reactome DB_ID: 379750

tRNA(Gly)
type: SmallMolecule
entity reference: CHEBI:29176
data source: Reactome
xref: UnificationXref4878
xref: UnificationXref4877
cellular location: GO:0005759
comment: Reactome DB_ID: 379770

Gln-tRNA(Gln)
type: SmallMolecule
entity reference: CHEBI:29166
data source: Reactome
xref: UnificationXref4873
xref: UnificationXref4872
cellular location: GO:0005759
comment: Reactome DB_ID: 379753

UnificationXref23543
type: UnificationXref
id: 4168416
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168416

UnificationXref23544
type: UnificationXref
id: 4168420
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168420

UnificationXref23541
type: UnificationXref
id: 4168414
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168414

UnificationXref23542
type: UnificationXref
id: 4168415
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168415

UnificationXref23540
type: UnificationXref
id: REACT_124222
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124222.1

tRNA(Gln)
type: SmallMolecule
entity reference: CHEBI:29168
data source: Reactome
xref: UnificationXref4871
xref: UnificationXref4870
cellular location: GO:0005759
comment: Reactome DB_ID: 379740

UnificationXref23549
type: UnificationXref
id: REACT_137198
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137198.5

UnificationXref23548
type: UnificationXref
id: 4168600
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168600

UnificationXref23547
type: UnificationXref
id: 4168598
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168598

UnificationXref23546
type: UnificationXref
id: 4168423
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168423

UnificationXref23545
type: UnificationXref
id: 4168422
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168422

tRNA(Asp)
type: SmallMolecule
entity reference: CHEBI:29186
data source: Reactome
xref: UnificationXref4837
xref: UnificationXref4838
cellular location: GO:0005759
comment: Reactome DB_ID: 379715

2-aminosuccinic acid
type: SmallMolecule
entity reference: CHEBI:17053
data source: Reactome
name: L-Aspartate
name: L-Aspartic acid
xref: UnificationXref4840
xref: UnificationXref4839
cellular location: GO:0005759
comment: Reactome DB_ID: 113553
display name: Asp

Asp-tRNA(Asp)
type: SmallMolecule
entity reference: CHEBI:29158
data source: Reactome
xref: UnificationXref4842
xref: UnificationXref4841
cellular location: GO:0005759
comment: Reactome DB_ID: 379698

tRNA(Cys)
type: SmallMolecule
entity reference: CHEBI:29167
data source: Reactome
xref: UnificationXref4848
xref: UnificationXref4849
cellular location: GO:0005759
comment: Reactome DB_ID: 379714

L-2-amino-3-mercaptopropionic acid
type: SmallMolecule
entity reference: CHEBI:17561
data source: Reactome
name: L-cysteine
xref: UnificationXref4850
xref: UnificationXref184
cellular location: GO:0005759
comment: Reactome DB_ID: 379721
display name: L-Cys

Cys-tRNA(Cys)
type: SmallMolecule
entity reference: CHEBI:29152
data source: Reactome
xref: UnificationXref4851
xref: UnificationXref4852
cellular location: GO:0005759
comment: Reactome DB_ID: 379713

tRNA(Glu)
type: SmallMolecule
entity reference: CHEBI:29175
data source: Reactome
xref: UnificationXref4858
xref: UnificationXref4857
cellular location: GO:0005759
comment: Reactome DB_ID: 379754

Glu-tRNA(Glu)
type: SmallMolecule
entity reference: CHEBI:29157
data source: Reactome
xref: UnificationXref4860
xref: UnificationXref4859
cellular location: GO:0005759
comment: Reactome DB_ID: 379744

(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid
type: SmallMolecule
entity reference: CHEBI:17895
data source: Reactome
name: L-Tyrosine
name: (S)-3-(p-Hydroxyphenyl)alanine
xref: UnificationXref5009
xref: UnificationXref5008
cellular location: GO:0005759
comment: Reactome DB_ID: 379710
display name: L-Tyr

Trp-tRNA(Trp)
type: SmallMolecule
entity reference: CHEBI:29159
data source: Reactome
xref: UnificationXref4999
xref: UnificationXref5000
cellular location: GO:0005759
comment: Reactome DB_ID: 379759

(S)-alpha-amino-beta-(3-indolyl)-propionic acid
type: SmallMolecule
entity reference: CHEBI:16828
data source: Reactome
name: L-Tryptophan
xref: UnificationXref4998
xref: UnificationXref178
cellular location: GO:0005759
comment: Reactome DB_ID: 379709
display name: L-Trp

tRNA(Trp)
type: SmallMolecule
entity reference: CHEBI:29181
data source: Reactome
xref: UnificationXref4997
xref: UnificationXref4996
cellular location: GO:0005759
comment: Reactome DB_ID: 379774

Thr-tRNA(Thr)
type: SmallMolecule
entity reference: CHEBI:29163
data source: Reactome
xref: UnificationXref4987
xref: UnificationXref4988
cellular location: GO:0005759
comment: Reactome DB_ID: 379779

UnificationXref23510
type: UnificationXref
id: 4168468
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168468

UnificationXref23511
type: UnificationXref
id: 4168470
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168470

UnificationXref23513
type: UnificationXref
id: 4168651
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168651

UnificationXref23512
type: UnificationXref
id: REACT_132605
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132605.5

UnificationXref23515
type: UnificationXref
id: 4168382
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168382

UnificationXref23514
type: UnificationXref
id: REACT_131155
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131155.5

UnificationXref23517
type: UnificationXref
id: REACT_137304
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137304.5

UnificationXref23516
type: UnificationXref
id: 4168384
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168384

UnificationXref23519
type: UnificationXref
id: 4168406
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168406

UnificationXref23518
type: UnificationXref
id: 4168404
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168404

tRNA(Thr)
type: SmallMolecule
entity reference: CHEBI:29180
data source: Reactome
xref: UnificationXref4984
xref: UnificationXref4983
cellular location: GO:0005759
comment: Reactome DB_ID: 379791

L-Threonine
type: SmallMolecule
entity reference: CHEBI:16857
data source: Reactome
xref: UnificationXref4986
xref: UnificationXref4985
cellular location: GO:0005759
comment: Reactome DB_ID: 379706
display name: L-Thr

L-serine
type: SmallMolecule
entity reference: CHEBI:17115
data source: Reactome
xref: UnificationXref4972
xref: UnificationXref4971
cellular location: GO:0005759
comment: Reactome DB_ID: 379732
display name: L-Ser

Ser-tRNA(Ser)
type: SmallMolecule
entity reference: CHEBI:29162
data source: Reactome
xref: UnificationXref4973
xref: UnificationXref4974
cellular location: GO:0005759
comment: Reactome DB_ID: 379777

Pro-tRNA(Pro)
type: SmallMolecule
entity reference: CHEBI:29154
data source: Reactome
xref: UnificationXref4959
xref: UnificationXref4958
cellular location: GO:0005759
comment: Reactome DB_ID: 379745

tRNA(Ser)
type: SmallMolecule
entity reference: CHEBI:29179
data source: Reactome
xref: UnificationXref4969
xref: UnificationXref4970
cellular location: GO:0005759
comment: Reactome DB_ID: 379761

Phe-tRNA(Phe)
type: SmallMolecule
entity reference: CHEBI:29153
data source: Reactome
xref: UnificationXref4949
xref: UnificationXref4948
cellular location: GO:0005759
comment: Reactome DB_ID: 379789

tRNA(Phe)
type: SmallMolecule
entity reference: CHEBI:29184
data source: Reactome
xref: UnificationXref4946
xref: UnificationXref4947
cellular location: GO:0005759
comment: Reactome DB_ID: 379760

2-Pyrrolidinecarboxylic acid
type: SmallMolecule
entity reference: CHEBI:17203
data source: Reactome
name: L-Proline
xref: UnificationXref4957
xref: UnificationXref4956
cellular location: GO:0005759
comment: Reactome DB_ID: 379717
display name: L-Pro

tRNA(Pro)
type: SmallMolecule
entity reference: CHEBI:29177
data source: Reactome
xref: UnificationXref4955
xref: UnificationXref4954
cellular location: GO:0005759
comment: Reactome DB_ID: 379775

UnificationXref23521
type: UnificationXref
id: 4168554
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168554

UnificationXref23522
type: UnificationXref
id: REACT_143044
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143044.5

UnificationXref23520
type: UnificationXref
id: REACT_145181
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145181.5

UnificationXref23526
type: UnificationXref
id: REACT_124533
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124533.1

UnificationXref23525
type: UnificationXref
id: 1806200
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806200

UnificationXref23524
type: UnificationXref
id: REACT_129378
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129378.5

UnificationXref23523
type: UnificationXref
id: 4175839
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175839

UnificationXref23529
type: UnificationXref
id: 4168634
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168634

UnificationXref23528
type: UnificationXref
id: REACT_124477
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124477.1

UnificationXref23527
type: UnificationXref
id: 1806205
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806205

tRNA(Met)
type: SmallMolecule
entity reference: CHEBI:29173
data source: Reactome
xref: UnificationXref4938
xref: UnificationXref4937
cellular location: GO:0005759
comment: Reactome DB_ID: 379741

Met-tRNA(Met)
type: SmallMolecule
entity reference: CHEBI:16635
data source: Reactome
xref: UnificationXref4939
xref: UnificationXref4940
cellular location: GO:0005759
comment: Reactome DB_ID: 379780

L-Phenylalanine
type: SmallMolecule
entity reference: CHEBI:17295
data source: Reactome
name: (S)-alpha-amino-beta-phenylpropionic acid
xref: UnificationXref4945
xref: UnificationXref172
cellular location: GO:0005759
comment: Reactome DB_ID: 379701
display name: L-Phe

2,6-diaminohexanoic acid
type: SmallMolecule
entity reference: CHEBI:18019
data source: Reactome
name: Lysine acid
name: L-Lysine
xref: UnificationXref4924
xref: UnificationXref4923
cellular location: GO:0005759
comment: Reactome DB_ID: 29444
display name: L-Lys

tRNA(Lys)
type: SmallMolecule
entity reference: CHEBI:29185
data source: Reactome
xref: UnificationXref4925
xref: UnificationXref4926
cellular location: GO:0005759
comment: Reactome DB_ID: 379747

Lys-tRNA(Lys)
type: SmallMolecule
entity reference: CHEBI:16047
data source: Reactome
xref: UnificationXref4927
xref: UnificationXref4928
cellular location: GO:0005759
comment: Reactome DB_ID: 379795

L-Methionine
type: SmallMolecule
entity reference: CHEBI:16643
data source: Reactome
xref: UnificationXref4936
xref: UnificationXref170
cellular location: GO:0005759
comment: Reactome DB_ID: 379705
display name: L-Met

SequenceSite11876
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11877
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11878
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11879
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11872
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11873
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11874
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11875
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11871
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11870
type: SequenceSite
position status: EQUAL
sequence position: 4391

UnificationXref23500
type: UnificationXref
id: CHEBI:16500
db: ChEBI

SequenceSite11869
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11867
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11868
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11865
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11866
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11863
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11864
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11861
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite11862
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite11860
type: SequenceSite
position status: EQUAL
sequence position: 529

UnificationXref23509
type: UnificationXref
id: REACT_130169
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130169.5

UnificationXref23507
type: UnificationXref
id: REACT_122144
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122144.1

UnificationXref23508
type: UnificationXref
id: 4168622
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168622

UnificationXref23505
type: UnificationXref
id: REACT_128132
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128132.5

UnificationXref23506
type: UnificationXref
id: 1806224
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806224

UnificationXref23503
type: UnificationXref
id: 4168436
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168436

UnificationXref23504
type: UnificationXref
id: 4168438
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168438

UnificationXref23501
type: UnificationXref
id: 1806240
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806240

UnificationXref23502
type: UnificationXref
id: REACT_123499
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123499.1

SequenceSite11894
type: SequenceSite
position status: EQUAL
sequence position: 2322

Asn-tRNA(Asn)
type: SmallMolecule
entity reference: CHEBI:29265
data source: Reactome
xref: UnificationXref4831
xref: UnificationXref4832
cellular location: GO:0005759
comment: Reactome DB_ID: 379718

SequenceSite11895
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11896
type: SequenceSite
position status: EQUAL
sequence position: 329

SequenceSite11897
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11898
type: SequenceSite
position status: EQUAL
sequence position: 329

Activation of TALK
type: BiochemicalReaction
data source: Reactome
evidence: Evidence152
xref: UnificationXref2417
xref: UnificationXref2416
left: SmallMolecule15
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule20

SequenceSite11899
type: SequenceSite
position status: EQUAL
sequence position: 24

Activation of Ca2+ activated Potassium channels with small conductance
type: BiochemicalReaction
data source: Reactome
evidence: Evidence136
xref: UnificationXref2121
xref: UnificationXref2122
left: SmallMolecule15
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule20

Arg-tRNA(Arg)
type: SmallMolecule
entity reference: CHEBI:18366
data source: Reactome
xref: UnificationXref4822
xref: UnificationXref4821
cellular location: GO:0005759
comment: Reactome DB_ID: 379708

Activation of Ca2+ activated Potassium channels with Intermeidtance conductance
type: BiochemicalReaction
data source: Reactome
evidence: Evidence135
xref: UnificationXref2115
xref: UnificationXref2114
left: SmallMolecule15
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule20

5'-Adenylic acid
type: SmallMolecule
entity reference: CHEBI:16027
data source: Reactome
name: Adenylate
name: Adenosine 5'-phosphate
name: 5'-AMP
name: 5'-Adenosine monophosphate
name: adenosine 5'-monophosphate
name: Adenylic acid
xref: UnificationXref4819
xref: UnificationXref4820
cellular location: GO:0005759
comment: Reactome DB_ID: 159448
display name: AMP

Activation of GIRK/Kir3 Channels
type: BiochemicalReaction
data source: Reactome
evidence: Evidence128
xref: UnificationXref2099
xref: UnificationXref2098
left: SmallMolecule15
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule20

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15422
data source: Reactome
xref: UnificationXref4818
xref: UnificationXref4817
cellular location: GO:0005759
comment: Reactome DB_ID: 113593
display name: ATP

GABAB heterodimeric receptor binds GABA
type: BiochemicalReaction
data source: Reactome
evidence: Evidence127
xref: UnificationXref1896
xref: UnificationXref1895
left: gamma-aminobutyrate
left: Complex96
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex97

tRNA(Arg)
type: SmallMolecule
entity reference: CHEBI:29171
data source: Reactome
xref: UnificationXref4816
xref: UnificationXref4815
cellular location: GO:0005759
comment: Reactome DB_ID: 379727

Activation of classical Kir channels
type: BiochemicalReaction
data source: Reactome
evidence: Evidence145
xref: UnificationXref2262
xref: UnificationXref2263
left: SmallMolecule15
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule20

(S)-2-Amino-5-guanidinovaleric acid
type: SmallMolecule
entity reference: CHEBI:16467
data source: Reactome
name: L-Arginine
xref: UnificationXref4814
xref: UnificationXref4813
cellular location: GO:0005759
comment: Reactome DB_ID: 374064
display name: L-Arg

SequenceSite11891
type: SequenceSite
position status: EQUAL
sequence position: 30

Activation of Potassium transport channels
type: BiochemicalReaction
data source: Reactome
evidence: Evidence143
xref: UnificationXref2239
xref: UnificationXref2240
left: SmallMolecule15
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule20

Val-tRNA(Val)
type: SmallMolecule
entity reference: CHEBI:29164
data source: Reactome
xref: UnificationXref4802
xref: UnificationXref4803
cellular location: GO:0005829
comment: Reactome DB_ID: 379790

SequenceSite11890
type: SequenceSite
position status: EQUAL
sequence position: 2322

Activation of HCN channels
type: BiochemicalReaction
data source: Reactome
evidence: Evidence139
xref: UnificationXref2212
xref: UnificationXref2213
left: SmallMolecule15
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule20

tRNA(Val)
type: SmallMolecule
entity reference: CHEBI:29183
data source: Reactome
xref: UnificationXref4800
xref: UnificationXref4799
cellular location: GO:0005829
comment: Reactome DB_ID: 379793

SequenceSite11893
type: SequenceSite
position status: EQUAL
sequence position: 30

Binding of cAMP to HCN channels
type: BiochemicalReaction
data source: Reactome
evidence: Evidence138
xref: UnificationXref2211
xref: UnificationXref2210
left: Complex107
left: Cyclic AMP
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex112

Tyr-tRNA(Tyr)
type: SmallMolecule
entity reference: CHEBI:29161
data source: Reactome
xref: UnificationXref4792
xref: UnificationXref4791
cellular location: GO:0005829
comment: Reactome DB_ID: 379785

SequenceSite11892
type: SequenceSite
position status: EQUAL
sequence position: 2322

http://identifiers.org/pubmed/9914500
type: PublicationXref
id: 9914500
author: di Padova, F
author: Freuler, F
author: Heilker, R
author: Eder, J
author: Pulfer, R
db: Pubmed
title: All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex
source: Eur J Biochem 259:253-61
year: 1999

Activation of TASK
type: BiochemicalReaction
data source: Reactome
evidence: Evidence150
xref: UnificationXref2407
xref: UnificationXref2406
left: SmallMolecule15
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule20

Activation of voltage gated Potassium channels
type: BiochemicalReaction
data source: Reactome
evidence: Evidence148
xref: UnificationXref2385
xref: UnificationXref2386
left: SmallMolecule15
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule20

tRNA(Asn)
type: SmallMolecule
entity reference: CHEBI:29172
data source: Reactome
xref: UnificationXref4830
xref: UnificationXref4829
cellular location: GO:0005759
comment: Reactome DB_ID: 379699

L-Asparagine
type: SmallMolecule
entity reference: CHEBI:17196
data source: Reactome
name: 2-Aminosuccinamic acid
xref: UnificationXref4827
xref: UnificationXref4828
cellular location: GO:0005759
comment: Reactome DB_ID: 379703
display name: L-Asn

http://identifiers.org/pubmed/10648629
type: PublicationXref
id: 10648629
author: Ong, SH
author: Zhang, Z
author: Falasca, M
author: Rodrigues, GA
author: Schlessinger, J
db: Pubmed
title: A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
source: Mol Cell Biol 20:1448-59
year: 2000

SequenceSite11885
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11886
type: SequenceSite
position status: EQUAL
sequence position: 442

SequenceSite11883
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11884
type: SequenceSite
position status: EQUAL
sequence position: 201

SequenceSite11889
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite11887
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11888
type: SequenceSite
position status: EQUAL
sequence position: 198

Formation of NR-MED1 Coactivator Complex
type: BiochemicalReaction
data source: Reactome
evidence: Evidence159
xref: UnificationXref2503
xref: UnificationXref2502
left: Protein1177
left: NR
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex124

Activation of TRESK
type: BiochemicalReaction
data source: Reactome
evidence: Evidence154
xref: UnificationXref2433
xref: UnificationXref2432
left: SmallMolecule15
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule20

YAP1 binds TEAD
type: BiochemicalReaction
data source: Reactome
evidence: Evidence162
xref: UnificationXref2520
xref: UnificationXref2519
left: Protein1184
left: Protein1178
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex126

WWTR1 (TAZ) binds TEAD
type: BiochemicalReaction
data source: Reactome
evidence: Evidence161
xref: UnificationXref2516
xref: UnificationXref2515
left: Protein1183
left: Protein1178
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex125

Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4
type: BiochemicalReaction
data source: Reactome
evidence: Evidence166
xref: UnificationXref2569
xref: UnificationXref2570
participant stoichiometry: Stoichiometry416
left: Protein1191
left: Phospho-R-SMAD
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex128

SequenceSite11882
type: SequenceSite
position status: EQUAL
sequence position: 310

WWTR1 (TAZ) binds RUNX2
type: BiochemicalReaction
data source: Reactome
evidence: Evidence163
xref: UnificationXref2531
xref: UnificationXref2532
left: Protein1185
left: Protein1183
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex127

SequenceSite11881
type: SequenceSite
position status: EQUAL
sequence position: 18

Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
type: BiochemicalReaction
data source: Reactome
evidence: Evidence168
EC number: 2.7.11
xref: UnificationXref2614
xref: UnificationXref2613
participant stoichiometry: Stoichiometry422
participant stoichiometry: Stoichiometry421
left: Adenosine 5'-triphosphate
left: Complex129
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Adenosine 5'-diphosphate
right: Complex130

SequenceSite11880
type: SequenceSite
position status: EQUAL
sequence position: 4391

The SMAD2/3:SMAD4 complex transfers to the nucleus
type: BiochemicalReaction
data source: Reactome
evidence: Evidence167
xref: UnificationXref2590
xref: UnificationXref2589
left: Complex128
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex129

WWTR1 binds SMAD2/3:SMAD4 heterotrimer
type: BiochemicalReaction
data source: Reactome
evidence: Evidence169
xref: UnificationXref2618
xref: UnificationXref2617
left: Complex128
left: Protein1236
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex134

Raf activation
type: BiochemicalReaction
data source: Reactome
evidence: Evidence101
xref: UnificationXref1547
xref: UnificationXref1546
left: Complex83
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex85
right: ADP

Activation of MAPK
type: BiochemicalReaction
data source: Reactome
evidence: Evidence102
xref: UnificationXref1552
xref: UnificationXref1553
left: Adenosine 5'-triphosphate
left: Protein546
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein547
right: Adenosine 5'-diphosphate

Phosphorylation by MAPK/ERK
type: BiochemicalReaction
data source: Reactome
evidence: Evidence103
xref: UnificationXref1592
xref: UnificationXref1591
participant stoichiometry: Stoichiometry349
participant stoichiometry: Stoichiometry348
left: Adenosine 5'-triphosphate
left: Ribosomal S6 kinase
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Phospho(S363,S380,T573)-ribosomal S6 kinase
right: Adenosine 5'-diphosphate

Phophorylation by PDK1
type: BiochemicalReaction
data source: Reactome
evidence: Evidence104
xref: UnificationXref1634
xref: UnificationXref1635
left: Phospho(S363,S380,T573)- ribosomal S6 kinase
left: Adenosine 5'-triphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Adenosine 5'-diphosphate
right: Phospho(S221,S363,S380,T573)- ribosomal S6 kinase

Activation of Ca permeable AMPA receptors
type: BiochemicalReaction
data source: Reactome
evidence: Evidence94
xref: UnificationXref1517
xref: UnificationXref1518
left: SmallMolecule10
left: Complex81
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex78
right: SmallMolecule13
right: SmallMolecule22

Ca impermeable AMPA receptor ligand binding
type: BiochemicalReaction
data source: Reactome
evidence: Evidence95
xref: UnificationXref1520
xref: UnificationXref1521
left: Complex66
left: SmallMolecule13
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex82

Activation of Ca impermeable AMPA receptors
type: BiochemicalReaction
data source: Reactome
evidence: Evidence96
xref: UnificationXref1522
xref: UnificationXref1523
left: SmallMolecule10
left: Complex82
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex66
right: SmallMolecule13
right: SmallMolecule22

Membrane depolarization upon activation of Ca impermeable AMPA receptors
type: BiochemicalReaction
data source: Reactome
evidence: Evidence99
xref: UnificationXref1529
xref: UnificationXref1528
left: SmallMolecule10
left: Complex66
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex66
right: SmallMolecule22

Ca permeable AMPA receptor ligand binding
type: BiochemicalReaction
data source: Reactome
evidence: Evidence92
xref: UnificationXref1509
xref: UnificationXref1510
left: Complex78
left: SmallMolecule13
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex81

Activation of Ca permeable AMPA receptors
type: BiochemicalReaction
data source: Reactome
evidence: Evidence93
xref: UnificationXref1516
xref: UnificationXref1515
left: Complex81
left: Calcium
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Calcium
right: Complex78
right: SmallMolecule13

SequenceSite11835
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite11834
type: SequenceSite
position status: EQUAL
sequence position: 2322

SequenceSite11833
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite11832
type: SequenceSite
position status: EQUAL
sequence position: 198

SequenceSite11831
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11830
type: SequenceSite
position status: EQUAL
sequence position: 442

UniProt:Q9GYU8
type: ProteinReference
xref: UnificationXref4435
organism: BioSource1

SequenceSite11839
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11838
type: SequenceSite
position status: EQUAL
sequence position: 2322

UniProt:Q9GYU7
type: ProteinReference
xref: UnificationXref13881
organism: BioSource1

SequenceSite11837
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite11836
type: SequenceSite
position status: EQUAL
sequence position: 2322

2GABRA:2GABRB:GABRG:GABA transports extracellular Cl- to cytosol
type: BiochemicalReaction
data source: Reactome
evidence: Evidence125
xref: UnificationXref1873
xref: UnificationXref1874
left: SmallMolecule78
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule81

Activation of Edited Kainate receptors
type: BiochemicalReaction
data source: Reactome
evidence: Evidence119
xref: UnificationXref1809
xref: UnificationXref1808
left: SmallMolecule10
left: Complex92
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule13
right: Complex88
right: SmallMolecule22

GRIK3 homomer binds glutamate
type: BiochemicalReaction
data source: Reactome
evidence: Evidence122
xref: UnificationXref1845
xref: UnificationXref1846
left: Complex93
left: SmallMolecule13
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex94

Activation of CaMKK
type: BiochemicalReaction
data source: Reactome
evidence: Evidence114
EC number: 2.7.11.17
xref: UnificationXref1705
xref: UnificationXref1704
left: Adenosine 5'-triphosphate
left: Protein639
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein642
right: Adenosine 5'-diphosphate

Edited Kainate Receptor binds glutamate
type: BiochemicalReaction
data source: Reactome
evidence: Evidence118
xref: UnificationXref1807
xref: UnificationXref1806
left: SmallMolecule13
left: Complex88
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex92

CaMKII enters nucleus
type: BiochemicalReaction
data source: Reactome
evidence: Evidence111
xref: UnificationXref1691
xref: UnificationXref1690
left: Complex86
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex87

Phosphorylation of CREB by CaMKII
type: BiochemicalReaction
data source: Reactome
evidence: Evidence112
EC number: 2.7.11.17
xref: UnificationXref1693
xref: UnificationXref1692
left: Adenosine 5'-triphosphate
left: Protein614
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein615
right: Adenosine 5'-diphosphate

Activation of Adenylate Cyclase
type: BiochemicalReaction
data source: Reactome
evidence: Evidence108
EC number: 4.6.1.1
xref: UnificationXref1667
xref: UnificationXref1668
left: Adenosine 5'-triphosphate
left: Calcium
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Calcium
right: Cyclic AMP
right: SmallMolecule2

Phosphorylation of CREB by PKA
type: BiochemicalReaction
data source: Reactome
evidence: Evidence109
xref: UnificationXref1672
xref: UnificationXref1671
left: Adenosine 5'-triphosphate
left: Protein614
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein615
right: Adenosine 5'-diphosphate

Phosphorylation of CREB by ribosomal protein S6 kinase
type: BiochemicalReaction
data source: Reactome
evidence: Evidence106
xref: UnificationXref1642
xref: UnificationXref1641
left: Adenosine 5'-triphosphate
left: Protein614
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein615
right: Adenosine 5'-diphosphate

SequenceSite11822
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11821
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11824
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11823
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11820
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11829
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11826
type: SequenceSite
position status: EQUAL
sequence position: 310

SequenceSite11825
type: SequenceSite
position status: EQUAL
sequence position: 18

SequenceSite11828
type: SequenceSite
position status: EQUAL
sequence position: 201

SequenceSite11827
type: SequenceSite
position status: EQUAL
sequence position: 19

Transport of Choline
type: BiochemicalReaction
data source: Reactome
evidence: Evidence63
xref: UnificationXref1163
xref: UnificationXref1164
left: SmallMolecule10
left: Choline
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Choline
right: SmallMolecule22

Cho is acetylated to AcCho by CHAT
type: BiochemicalReaction
data source: Reactome
evidence: Evidence64
EC number: 2.3.1.6
xref: UnificationXref1176
xref: UnificationXref1177
left: Acetyl coenzyme A
left: Choline
display name: Synthesis of o-acetylcholine
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: coenzyme A
right: O-acetylcholine

Loading of acetylcholine in synaptic vesicle
type: BiochemicalReaction
data source: Reactome
evidence: Evidence65
xref: UnificationXref1191
xref: UnificationXref1190
participant stoichiometry: Stoichiometry265
participant stoichiometry: Stoichiometry259
left: O-acetylcholine
left: Complex48
left: H+
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex49
right: SmallMolecule21

Acetylcholine synaptic vesicle docking and priming
type: BiochemicalReaction
data source: Reactome
evidence: Evidence66
xref: UnificationXref1194
xref: UnificationXref1193
left: Protein370
left: Protein372
left: Protein367
left: Complex49
left: Protein371
left: Protein357
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex50

Synthesis of GABA by GAD1
type: BiochemicalReaction
data source: Reactome
evidence: Evidence68
EC number: 4.1.1.15
xref: UnificationXref1207
xref: UnificationXref1208
left: Pyridoxal 5'-phosphate
left: SmallMolecule18
left: SmallMolecule21
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Pyridoxal 5'-phosphate
right: Carbon dioxide
right: SmallMolecule68

Synthesis of GABA by GAD2
type: BiochemicalReaction
data source: Reactome
evidence: Evidence69
EC number: 4.1.1.15
xref: UnificationXref1214
xref: UnificationXref1213
left: Pyridoxal 5'-phosphate
left: SmallMolecule18
left: SmallMolecule21
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Pyridoxal 5'-phosphate
right: Carbon dioxide
right: SmallMolecule68

loading of Serotonin in synaptic vesicles
type: BiochemicalReaction
data source: Reactome
evidence: Evidence56
xref: UnificationXref1084
xref: UnificationXref1083
left: 3-(2-Aminoethyl)-1H-indol-5-ol
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: 5-Hydroxytryptamine

glutamine + H2O => glutamate + NH4+ [GLS]
type: BiochemicalReaction
data source: Reactome
evidence: Evidence58
EC number: 3.5.1.2
xref: UnificationXref1130
xref: UnificationXref1129
left: SmallMolecule5
left: L-Glutamine
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: L-Glutaminic acid
right: NH4+

L-Glutamate loading of synaptic vesicle
type: BiochemicalReaction
data source: Reactome
evidence: Evidence59
xref: UnificationXref1148
xref: UnificationXref1147
left: SmallMolecule18
left: Complex45
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex46

Glutamate synaptic vesicle docking and priming
type: BiochemicalReaction
data source: Reactome
evidence: Evidence60
xref: UnificationXref1150
xref: UnificationXref1151
left: Protein370
left: Protein372
left: Protein367
left: Complex46
left: Protein371
left: Protein357
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex47

UniProt:P24785
type: ProteinReference
xref: UnificationXref4038
organism: BioSource1

SequenceSite11853
type: SequenceSite
position status: EQUAL
sequence position: 25

SequenceSite11852
type: SequenceSite
position status: EQUAL
sequence position: 554

SequenceSite11851
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite11850
type: SequenceSite
position status: EQUAL
sequence position: 554

SequenceSite11857
type: SequenceSite
position status: EQUAL
sequence position: 19

UnificationXref23590
type: UnificationXref
id: 1806195
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806195

SequenceSite11856
type: SequenceSite
position status: EQUAL
sequence position: 529

UnificationXref23591
type: UnificationXref
id: REACT_125114
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125114.1

SequenceSite11855
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11854
type: SequenceSite
position status: EQUAL
sequence position: -1

UnificationXref23594
type: UnificationXref
id: 4168579
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168579

UnificationXref23595
type: UnificationXref
id: REACT_141442
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141442.5

SequenceSite11859
type: SequenceSite
position status: EQUAL
sequence position: 24

UnificationXref23592
type: UnificationXref
id: 4168488
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168488

SequenceSite11858
type: SequenceSite
position status: EQUAL
sequence position: 529

UnificationXref23593
type: UnificationXref
id: REACT_128746
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128746.5

UnificationXref23598
type: UnificationXref
id: 4175841
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175841

UnificationXref23599
type: UnificationXref
id: REACT_146836
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146836.5

UnificationXref23596
type: UnificationXref
id: 4168435
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168435

UnificationXref23597
type: UnificationXref
id: REACT_133386
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133386.5

Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites
type: BiochemicalReaction
data source: Reactome
evidence: Evidence87
xref: UnificationXref1478
xref: UnificationXref1479
left: Adenosine 5'-triphosphate
left: Complex61
left: Protein457
left: Protein454
left: Complex62
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex61
right: Complex66
right: Protein494
right: SmallMolecule3
right: Adenosine 5'-diphosphate
right: Protein497

Trafficking of GluR2-containing AMPA receptors to synapse
type: BiochemicalReaction
data source: Reactome
evidence: Evidence88
EC number: 3.6.1.3
xref: UnificationXref1488
xref: UnificationXref1487
left: Adenosine 5'-triphosphate
left: Complex66
left: Protein494
left: SmallMolecule3
left: Protein497
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex66
right: Protein494
right: Adenosine 5'-diphosphate
right: Protein497

5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid
type: BiochemicalReaction
data source: Reactome
evidence: Evidence80
EC number: 1.2.1.3
xref: UnificationXref1336
xref: UnificationXref1335
left: DPN
left: 5-hydroxyindole acetaldehyde
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: 5-Hydroxyindole acetic acid
right: NADH
right: H+

glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]
type: BiochemicalReaction
data source: Reactome
evidence: Evidence84
EC number: mate-ammonia
EC number: 6.3.1.2
xref: UnificationXref1351
xref: UnificationXref1352
left: NH4+
left: Adenosine 5'-triphosphate
left: SmallMolecule18
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule46
right: SmallMolecule3
right: Adenosine 5'-diphosphate

Endocytosis of Ca impermeable AMPA receptors
type: BiochemicalReaction
data source: Reactome
evidence: Evidence89
xref: UnificationXref1500
xref: UnificationXref1499
left: Adenosine 5'-triphosphate
left: Protein494
left: Complex74
left: Protein467
left: Protein497
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein457
right: Protein454
right: Protein467
right: SmallMolecule3
right: Complex62
right: Adenosine 5'-diphosphate

Loading of GABA into clathrin sculpted GABA transport vesicle lumen
type: BiochemicalReaction
data source: Reactome
evidence: Evidence71
xref: UnificationXref1241
xref: UnificationXref1240
left: Complex55
left: SmallMolecule68
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: gamma-aminobutyrate
right: Complex56

Conversion of GABA to Succinate Semialdehyde
type: BiochemicalReaction
data source: Reactome
evidence: Evidence75
EC number: 2.6.1.19
xref: UnificationXref1275
xref: UnificationXref1274
left: GABA
left: Pyridoxal 5'-phosphate
left: Oxoglutaric acid
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Pyridoxal 5'-phosphate
right: succinate semialdehyde
right: L-Glutaminic acid

Conversion of succinate semialdehyde to succinate
type: BiochemicalReaction
data source: Reactome
evidence: Evidence76
EC number: 1.2.1.24
xref: UnificationXref1288
xref: UnificationXref1287
left: SmallMolecule5
left: succinate semialdehyde
left: DPN
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: NADH
right: Ethylenesuccinic acid

GABA loaded synaptic vesicle Docking and Priming
type: BiochemicalReaction
data source: Reactome
evidence: Evidence72
xref: UnificationXref1243
xref: UnificationXref1244
left: Protein370
left: Protein372
left: Protein367
left: Protein371
left: Protein357
left: Complex56
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex57

GAT1-3 mediate Na+/Cl- dependent GABA transport
type: BiochemicalReaction
data source: Reactome
evidence: Evidence73
xref: UnificationXref1256
xref: UnificationXref1257
participant stoichiometry: Stoichiometry297
participant stoichiometry: Stoichiometry298
left: SmallMolecule10
left: gamma-aminobutyrate
left: SmallMolecule78
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule81
right: SmallMolecule68
right: SmallMolecule22

SequenceSite11840
type: SequenceSite
position status: EQUAL
sequence position: 327

SequenceSite11842
type: SequenceSite
position status: EQUAL
sequence position: 327

SequenceSite11841
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11844
type: SequenceSite
position status: EQUAL
sequence position: 327

SequenceSite11843
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11846
type: SequenceSite
position status: EQUAL
sequence position: 530

SequenceSite11845
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite11848
type: SequenceSite
position status: EQUAL
sequence position: 530

SequenceSite11847
type: SequenceSite
position status: EQUAL
sequence position: 24

UniProt:Q9GYV5
type: ProteinReference
xref: UnificationXref14681
organism: BioSource1

SequenceSite11849
type: SequenceSite
position status: EQUAL
sequence position: 24

UniProt:Q9GYV9
type: ProteinReference
xref: UnificationXref13848
organism: BioSource1

SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate
type: BiochemicalReaction
data source: Reactome
evidence: Evidence24
xref: UnificationXref453
xref: UnificationXref452
left: SmallMolecule39
left: SmallMolecule18
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule58
right: SmallMolecule13

SLC7A10-mediated uptake of small neutral amino acids
type: BiochemicalReaction
data source: Reactome
evidence: Evidence23
xref: UnificationXref445
xref: UnificationXref444
left: SmallMolecule94
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule97

Association of PARVA with TESK1
type: BiochemicalReaction
data source: Reactome
evidence: Evidence33
xref: UnificationXref540
xref: UnificationXref539
left: Protein131
left: Protein115
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex18

Rsu-1 interacts with Pinch1
type: BiochemicalReaction
data source: Reactome
evidence: Evidence32
xref: UnificationXref528
xref: UnificationXref527
left: Protein100
left: Protein128
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex17

DSCAM/DSCAML1 homodimerization
type: BiochemicalReaction
data source: Reactome
evidence: Evidence38
xref: UnificationXref563
xref: UnificationXref562
participant stoichiometry: Stoichiometry36
left: PhysicalEntity6
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex20

PARVB interacts with Alpha-actinin
type: BiochemicalReaction
data source: Reactome
evidence: Evidence34
xref: UnificationXref545
xref: UnificationXref544
left: Protein136
left: Protein116
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex19

SLC7A7 (y+LAT1)-mediated exchange of extracellular leucine for cytosolic arginine
type: BiochemicalReaction
data source: Reactome
evidence: Evidence26
xref: UnificationXref460
xref: UnificationXref457
left: SmallMolecule10
left: SmallMolecule44
left: SmallMolecule30
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule25
right: SmallMolecule22
right: SmallMolecule49

SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine
type: BiochemicalReaction
data source: Reactome
evidence: Evidence25
xref: UnificationXref456
xref: UnificationXref457
left: SmallMolecule10
left: SmallMolecule44
left: SmallMolecule30
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule25
right: SmallMolecule22
right: SmallMolecule49

PARVA associates with Paxillin
type: BiochemicalReaction
data source: Reactome
evidence: Evidence30
xref: UnificationXref518
xref: UnificationXref517
left: Protein117
left: Protein115
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex16

UnificationXref23578
type: UnificationXref
id: REACT_141001
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141001.5

Formation of the PINCH-ILK-parvin complex
type: BiochemicalReaction
data source: Reactome
evidence: Evidence29
xref: UnificationXref494
xref: UnificationXref493
left: Protein114
left: PhysicalEntity4
left: Protein110
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex15

UnificationXref23579
type: UnificationXref
id: 4168578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168578

UnificationXref23577
type: UnificationXref
id: 4168501
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168501

UnificationXref23576
type: UnificationXref
id: 4168486
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168486

UnificationXref23575
type: UnificationXref
id: 4168485
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168485

UnificationXref23574
type: UnificationXref
id: 4168484
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168484

UnificationXref23573
type: UnificationXref
id: 4168482
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168482

UnificationXref23572
type: UnificationXref
id: 4168474
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168474

UnificationXref23571
type: UnificationXref
id: 4168478
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168478

UnificationXref23570
type: UnificationXref
id: REACT_122302
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122302.1

Activation of JNK by DSCAM
type: BiochemicalReaction
data source: Reactome
evidence: Evidence41
EC number: 2.7.11
xref: UnificationXref607
xref: UnificationXref608
participant stoichiometry: Stoichiometry47
participant stoichiometry: Stoichiometry46
left: Adenosine 5'-triphosphate
left: Protein154
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Protein155
right: Adenosine 5'-diphosphate

DSCAM associates with Rac1-GTP:pPAK1
type: BiochemicalReaction
data source: Reactome
evidence: Evidence40
xref: UnificationXref595
xref: UnificationXref594
left: Protein137
left: Complex22
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex24

DSCAM binds Netrin-1
type: BiochemicalReaction
data source: Reactome
evidence: Evidence39
xref: UnificationXref570
xref: UnificationXref571
left: Protein143
left: Protein137
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex21

Uptake of Noradrenaline
type: BiochemicalReaction
data source: Reactome
evidence: Evidence53
evidence: Evidence54
xref: UnificationXref1074
xref: UnificationXref1075
left: Norepinephrine
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Norepinephrine

Noradrenalin synaptic vesicle docking and priming
type: BiochemicalReaction
data source: Reactome
evidence: Evidence52
xref: UnificationXref1065
xref: UnificationXref1066
left: Protein370
left: Complex40
left: Protein372
left: Protein367
left: Protein371
left: Protein357
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex41

Loading of dopamine into synaptic veiscles
type: BiochemicalReaction
data source: Reactome
evidence: Evidence51
xref: UnificationXref1027
xref: UnificationXref1026
left: Dopamine
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Dopamine

Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA
type: BiochemicalReaction
data source: Reactome
evidence: Evidence48
xref: UnificationXref1007
xref: UnificationXref1006
left: Complex30
left: Protein248
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex39

UnificationXref23589
type: UnificationXref
id: REACT_131856
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131856.5

Dissociation of L13a from the 60s ribosomal subunit
type: BiochemicalReaction
data source: Reactome
evidence: Evidence47
xref: UnificationXref795
xref: UnificationXref794
left: Complex28
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex29
right: Protein241

Nephrin trans-homophilic interaction
type: BiochemicalReaction
data source: Reactome
evidence: Evidence44
xref: UnificationXref650
xref: UnificationXref649
participant stoichiometry: Stoichiometry54
left: Protein168
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex27

Activation of p38MAPK by DSCAM
type: BiochemicalReaction
data source: Reactome
evidence: Evidence42
EC number: 2.7.11.24
xref: UnificationXref628
xref: UnificationXref627
participant stoichiometry: Stoichiometry50
participant stoichiometry: Stoichiometry51
left: Adenosine 5'-triphosphate
left: Complex25
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Complex26
right: Adenosine 5'-diphosphate

UnificationXref23586
type: UnificationXref
id: 4168432
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168432

UnificationXref23585
type: UnificationXref
id: 4168431
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168431

UnificationXref23588
type: UnificationXref
id: 4168595
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168595

UnificationXref23587
type: UnificationXref
id: 4168433
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168433

UnificationXref23582
type: UnificationXref
id: REACT_125583
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125583.1

UnificationXref23581
type: UnificationXref
id: 1806212
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806212

Ribosomal scanning and start codon recognition
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction321
pathway component: BiochemicalReaction320
evidence: Evidence472
xref: UnificationXref5691
xref: UnificationXref5690
pathway order: PathwayStep464
pathway order: PathwayStep463
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref23584
type: UnificationXref
id: 4168429
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168429

UnificationXref23583
type: UnificationXref
id: 4168427
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168427

UnificationXref23580
type: UnificationXref
id: REACT_128480
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128480.5

UnificationXref23558
type: UnificationXref
id: 4168552
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168552

UnificationXref23559
type: UnificationXref
id: REACT_140922
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140922.5

UnificationXref23556
type: UnificationXref
id: 1806180
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806180

UnificationXref23557
type: UnificationXref
id: REACT_122226
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122226.1

SequenceSite11816
type: SequenceSite
position status: EQUAL
sequence position: 4391

UnificationXref23551
type: UnificationXref
id: REACT_123880
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123880.1

SequenceSite11817
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref23550
type: UnificationXref
id: 1806199
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806199

SequenceSite11814
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11815
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref23555
type: UnificationXref
id: REACT_145516
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145516.5

UnificationXref23554
type: UnificationXref
id: 4168624
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168624

SequenceSite11818
type: SequenceSite
position status: EQUAL
sequence position: 4391

UnificationXref23553
type: UnificationXref
id: REACT_134967
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134967.5

SequenceSite11819
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref23552
type: UnificationXref
id: 4168535
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168535

SequenceSite11812
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11813
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11810
type: SequenceSite
position status: EQUAL
sequence position: 4391

SequenceSite11811
type: SequenceSite
position status: EQUAL
sequence position: 22

2,4-Dinitro-1-chlorobenzene
type: SmallMoleculeReference
name: 1-chloro-2,4-dinitrobenzene [ChEBI:34718]
name: DNCB
name: 1-Chloro-2,4-dinitrobenzol
name: 1-chloro-2,4-dinitrobenzene
name: Dncb
name: 6-Chloro-1,3-dinitrobenzene
name: Dinitrochlorobenzene
name: 1,3-Dinitro-4-chlorobenzene
name: Chlorodinitrobenzene
name: 2,4-Dinitrophenyl chloride
name: Cdnb
name: 4-Chloro-1,3-dinitrobenzene
name: 2,4-Dinitrochlorobenzene
xref: UnificationXref27887

SLC6A18-mediated glycine uptake
type: BiochemicalReaction
data source: Reactome
evidence: Evidence13
xref: UnificationXref318
xref: UnificationXref317
left: SmallMolecule41
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule60

http://identifiers.org/pubmed/5046811
type: PublicationXref
id: 5046811
author: Kishida, Y
author: Prockop, DJ
author: Kivirikko, KI
author: Sakakibara, S
db: Pubmed
title: Hydroxylation of (X-Pro-Gly)n by protocollagen proline hydroxylase. Effect of chain length, helical conformation and amino acid sequence in the substrate
source: Biochim Biophys Acta 271:347-56
year: 1972

SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine
type: BiochemicalReaction
data source: Reactome
evidence: Evidence17
xref: UnificationXref362
xref: UnificationXref363
participant stoichiometry: Stoichiometry16
participant stoichiometry: Stoichiometry15
left: SmallMolecule10
left: SmallMolecule78
left: SmallMolecule79
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule81
right: SmallMolecule82
right: SmallMolecule22

UnificationXref23567
type: UnificationXref
id: 1806198
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806198

SLC7A8-mediated uptake of neutral amino acids
type: BiochemicalReaction
data source: Reactome
evidence: Evidence16
xref: UnificationXref345
xref: UnificationXref344
left: SmallMolecule76
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule77

UnificationXref23568
type: UnificationXref
id: REACT_125283
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125283.1

SLC7A5-mediated uptake of neutral amino acids
type: BiochemicalReaction
data source: Reactome
evidence: Evidence15
xref: UnificationXref337
xref: UnificationXref336
left: SmallMolecule74
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule75

UnificationXref23569
type: UnificationXref
id: 1806289
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806289

SLC6A20-mediated uptake of proline
type: BiochemicalReaction
data source: Reactome
evidence: Evidence14
xref: UnificationXref323
xref: UnificationXref322
left: SmallMolecule10
left: SmallMolecule34
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule53
right: SmallMolecule22

SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids
type: BiochemicalReaction
data source: Reactome
evidence: Evidence21
xref: UnificationXref407
xref: UnificationXref393
left: SmallMolecule86
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule87

SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids
type: BiochemicalReaction
data source: Reactome
evidence: Evidence20
xref: UnificationXref405
xref: UnificationXref406
left: SmallMolecule88
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule89

SLC7A1 (CAT-1)-mediated uptake of cationic amino acids
type: BiochemicalReaction
data source: Reactome
evidence: Evidence19
xref: UnificationXref393
xref: UnificationXref392
left: SmallMolecule86
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule87

SLC6A19-mediated uptake of neutral amino acids
type: BiochemicalReaction
data source: Reactome
evidence: Evidence18
xref: UnificationXref372
xref: UnificationXref371
left: SmallMolecule10
left: SmallMolecule84
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule85
right: SmallMolecule22

SequenceSite11803
type: SequenceSite
position status: EQUAL
sequence position: 24

UnificationXref23560
type: UnificationXref
id: 1806238
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806238

http://identifiers.org/pubmed/12671646
type: PublicationXref
id: 12671646
author: Chao, MV
db: Pubmed
title: Neurotrophins and their receptors: a convergence point for many signalling pathways
source: Nat Rev Neurosci 4:299-309
year: 2003

SequenceSite11804
type: SequenceSite
position status: EQUAL
sequence position: 529

SLC7A3 (CAT-3)-mediated uptake of cationic amino acids
type: BiochemicalReaction
data source: Reactome
evidence: Evidence22
xref: UnificationXref426
xref: UnificationXref427
left: SmallMolecule90
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule92

SequenceSite11805
type: SequenceSite
position status: EQUAL
sequence position: 24

UnificationXref23562
type: UnificationXref
id: 4168653
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4168653

SequenceSite11806
type: SequenceSite
position status: EQUAL
sequence position: 529

UnificationXref23561
type: UnificationXref
id: REACT_125493
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125493.1

SequenceSite11807
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref23564
type: UnificationXref
id: 4175844
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175844

SequenceSite11808
type: SequenceSite
position status: EQUAL
sequence position: 4391

UnificationXref23563
type: UnificationXref
id: REACT_127908
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127908.5

SequenceSite11809
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref23566
type: UnificationXref
id: GO:0031902
db: GENE ONTOLOGY

UnificationXref23565
type: UnificationXref
id: REACT_131492
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131492.5

http://identifiers.org/pubmed/18760361
type: PublicationXref
id: 18760361
author: Maness, PF
author: Schmid, RS
db: Pubmed
title: L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth
source: Curr Opin Neurobiol 18:245-50
year: 2008

SequenceSite11800
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite11801
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11802
type: SequenceSite
position status: EQUAL
sequence position: 529

http://identifiers.org/pubmed/9536209
type: PublicationXref
id: 9536209
author: Clarke, D
author: Cunningham, SK
author: Fearon, U
author: McKenna, TJ
db: Pubmed
title: A critical review of the origin and control of adrenal androgens
source: Baillieres Clin Obstet Gynaecol 11:229-48
year: 1997

Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction2053
pathway component: BiochemicalReaction2054
pathway component: BiochemicalReaction2052
pathway component: BiochemicalReaction2051
evidence: Evidence2959
xref: UnificationXref28128
xref: RelationshipXref2042
xref: UnificationXref28127
pathway order: PathwayStep2948
pathway order: PathwayStep2949
pathway order: PathwayStep2951
pathway order: PathwayStep2950
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Transmission across Chemical Synapses
type: Pathway
data source: Reactome
pathway component: REACT 99114.9
pathway component: Neurotransmitter Release Cycle
pathway component: REACT 29399.10
pathway component: REACT 91125.9
evidence: Evidence134
xref: UnificationXref2111
xref: UnificationXref2110
xref: RelationshipXref97
pathway order: PathwayStep81
pathway order: PathwayStep78
pathway order: PathwayStep128
pathway order: PathwayStep74
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite993
type: SequenceSite
position status: EQUAL
sequence position: 369

SequenceSite994
type: SequenceSite
position status: EQUAL
sequence position: 386

SequenceSite995
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite996
type: SequenceSite
position status: EQUAL
sequence position: 740

SequenceSite997
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite998
type: SequenceSite
position status: EQUAL
sequence position: 733

SequenceSite999
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite990
type: SequenceSite
position status: EQUAL
sequence position: 386

SequenceSite992
type: SequenceSite
position status: EQUAL
sequence position: 740

SequenceSite991
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite989
type: SequenceSite
position status: EQUAL
sequence position: 369

SequenceSite988
type: SequenceSite
position status: EQUAL
sequence position: 740

http://identifiers.org/pubmed/11606068
type: PublicationXref
id: 11606068
author: Lorkowski, S
author: Rust, S
author: Engel, T
author: Berger, G
author: Assmann, G
author: Cullen, P
author: Lueken, A
author: Schlüter, B
db: Pubmed
title: The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages
source: Biochem Biophys Res Commun 288:483-8
year: 2001

SequenceSite987
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite986
type: SequenceSite
position status: EQUAL
sequence position: 386

SequenceSite985
type: SequenceSite
position status: EQUAL
sequence position: 369

SequenceSite984
type: SequenceSite
position status: EQUAL
sequence position: 745

SequenceSite983
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite982
type: SequenceSite
position status: EQUAL
sequence position: 745

SequenceSite980
type: SequenceSite
position status: EQUAL
sequence position: 745

SequenceSite981
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite976
type: SequenceSite
position status: EQUAL
sequence position: 570

SequenceSite975
type: SequenceSite
position status: EQUAL
sequence position: 377

http://identifiers.org/pubmed/20060739
type: PublicationXref
id: 20060739
author: Sheftel, Alex
author: Stehling, Oliver
author: Lill, R
db: Pubmed
title: Iron-sulfur proteins in health and disease
source: Trends Endocrinol. Metab. 21:302-14
year: 2010

SequenceSite978
type: SequenceSite
position status: EQUAL
sequence position: 733

SequenceSite977
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/10548110
type: PublicationXref
id: 10548110
author: Lukas, J
author: Kramer, E
author: Peters, JM
author: Lindeneg, C
author: Santoni-Rugiu, E
author: Sorensen, CS
author: Lukas, C
db: Pubmed
title: Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
source: Nature 401:815-8
year: 1999

SequenceSite972
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite971
type: SequenceSite
position status: EQUAL
sequence position: 570

SequenceSite974
type: SequenceSite
position status: EQUAL
sequence position: 360

SequenceSite973
type: SequenceSite
position status: EQUAL
sequence position: 733

SequenceSite979
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite970
type: SequenceSite
position status: EQUAL
sequence position: 377

SequenceSite963
type: SequenceSite
position status: EQUAL
sequence position: 735

SequenceSite962
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite961
type: SequenceSite
position status: EQUAL
sequence position: 573

SequenceSite960
type: SequenceSite
position status: EQUAL
sequence position: 380

SequenceSite967
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite966
type: SequenceSite
position status: EQUAL
sequence position: 570

SequenceSite965
type: SequenceSite
position status: EQUAL
sequence position: 377

SequenceSite964
type: SequenceSite
position status: EQUAL
sequence position: 360

SequenceSite969
type: SequenceSite
position status: EQUAL
sequence position: 360

SequenceSite968
type: SequenceSite
position status: EQUAL
sequence position: 733

SequenceSite950
type: SequenceSite
position status: EQUAL
sequence position: 380

http://identifiers.org/pubmed/183598
type: PublicationXref
id: 183598
author: Clark, P
author: Edwards, YH
author: Harris, H
db: Pubmed
title: Isozymes of glyceraldehyde-3-phosphate dehydrogenase in man and other mammals.
source: Ann Hum Genet 40:67-77
year: 1976

SequenceSite952
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite951
type: SequenceSite
position status: EQUAL
sequence position: 573

SequenceSite954
type: SequenceSite
position status: EQUAL
sequence position: 363

SequenceSite953
type: SequenceSite
position status: EQUAL
sequence position: 735

SequenceSite956
type: SequenceSite
position status: EQUAL
sequence position: 573

SequenceSite955
type: SequenceSite
position status: EQUAL
sequence position: 380

SequenceSite958
type: SequenceSite
position status: EQUAL
sequence position: 735

SequenceSite957
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite959
type: SequenceSite
position status: EQUAL
sequence position: 363

http://identifiers.org/pubmed/183599
type: PublicationXref
id: 183599
author: Hers, HG
db: Pubmed
title: The control of glycogen metabolism in the liver
source: Annu Rev Biochem 45:167-89
year: 1976

UnificationXref1944
type: UnificationXref
id: 4164961
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164961

UnificationXref15095
type: UnificationXref
id: 4165396
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165396

UnificationXref1943
type: UnificationXref
id: 4164960
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164960

UnificationXref15094
type: UnificationXref
id: 4165395
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165395

UnificationXref1946
type: UnificationXref
id: 4164963
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164963

UnificationXref15093
type: UnificationXref
id: 4165394
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165394

UnificationXref1945
type: UnificationXref
id: 4164962
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164962

UnificationXref15092
type: UnificationXref
id: REACT_154080
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154080.3

UnificationXref1940
type: UnificationXref
id: 4164957
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164957

UnificationXref15099
type: UnificationXref
id: REACT_140517
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140517.5

UnificationXref15098
type: UnificationXref
id: 4165411
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165411

UnificationXref1942
type: UnificationXref
id: 4164959
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164959

UnificationXref15097
type: UnificationXref
id: 4165409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165409

UniProt:F3YDP6
type: ProteinReference
xref: UnificationXref29805
organism: BioSource1

UnificationXref1941
type: UnificationXref
id: 4164958
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164958

UnificationXref15096
type: UnificationXref
id: REACT_136977
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136977.5

UniProt:F3YDP0
type: ProteinReference
xref: UnificationXref28244
organism: BioSource1

UnificationXref1947
type: UnificationXref
id: 4164964
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164964

UnificationXref1948
type: UnificationXref
id: 4164965
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164965

UnificationXref1949
type: UnificationXref
id: 4164966
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164966

UniProt:C8VV38
type: ProteinReference
xref: UnificationXref22986
organism: BioSource1

UnificationXref1935
type: UnificationXref
id: 4164952
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164952

UnificationXref1934
type: UnificationXref
id: C9QPA7
db: UniProt

UnificationXref1933
type: UnificationXref
id: 4164950
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164950

UnificationXref1932
type: UnificationXref
id: Q9VJ56
db: UniProt

UnificationXref1931
type: UnificationXref
id: 4164948
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164948

UnificationXref1930
type: UnificationXref
id: Q9VCQ0
db: UniProt

UnificationXref1938
type: UnificationXref
id: 4164955
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164955

UnificationXref1939
type: UnificationXref
id: 4164956
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164956

UnificationXref1936
type: UnificationXref
id: 4164953
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164953

Pre-NOTCH Processing in the Endoplasmic Reticulum
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction642
pathway component: BiochemicalReaction643
evidence: Evidence1001
xref: UnificationXref10531
xref: UnificationXref10532
pathway order: PathwayStep996
pathway order: PathwayStep997
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1937
type: UnificationXref
id: 4164954
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164954

UniProt:C8VV32
type: ProteinReference
xref: UnificationXref6021
organism: BioSource1

UniProt:C8VV36
type: ProteinReference
xref: UnificationXref29510
organism: BioSource1

UniProt:C8VV34
type: ProteinReference
xref: UnificationXref21707
organism: BioSource1

UniProt:C8VV48
type: ProteinReference
xref: UnificationXref303
organism: BioSource1

UnificationXref1920
type: UnificationXref
id: A2RVG0
db: UniProt

UnificationXref1922
type: UnificationXref
id: Q8IMY7
db: UniProt

UnificationXref1921
type: UnificationXref
id: 4164938
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164938

UnificationXref1924
type: UnificationXref
id: Q95UP7
db: UniProt

UnificationXref1923
type: UnificationXref
id: 4164940
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164940

UnificationXref1925
type: UnificationXref
id: 4164942
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164942

UnificationXref1926
type: UnificationXref
id: E1JIU2
db: UniProt

UnificationXref1927
type: UnificationXref
id: 4164944
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164944

UnificationXref1928
type: UnificationXref
id: A8JR87
db: UniProt

UnificationXref1929
type: UnificationXref
id: 4164946
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164946

UniProt:C8VV40
type: ProteinReference
xref: UnificationXref5244
organism: BioSource1

UniProt:C8VV43
type: ProteinReference
xref: UnificationXref9336
organism: BioSource1

UnificationXref1913
type: UnificationXref
id: 4164928
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164928

UnificationXref1912
type: UnificationXref
id: C4IY03
db: UniProt

UnificationXref1911
type: UnificationXref
id: 4164926
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164926

UnificationXref1910
type: UnificationXref
id: B7YZX2
db: UniProt

UnificationXref1916
type: UnificationXref
id: Q9VCL9
db: UniProt

UnificationXref1917
type: UnificationXref
id: 4164932
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164932

UnificationXref1914
type: UnificationXref
id: Q8IGY2
db: UniProt

UnificationXref1915
type: UnificationXref
id: 4164930
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164930

UnificationXref1918
type: UnificationXref
id: A2RVC9
db: UniProt

UnificationXref1919
type: UnificationXref
id: 4164936
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164936

UniProt:C8VV56
type: ProteinReference
xref: UnificationXref22970
organism: BioSource1

UniProt:C8VV53
type: ProteinReference
xref: UnificationXref15247
organism: BioSource1

UnificationXref1900
type: UnificationXref
id: 4162622
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4162622

UnificationXref1901
type: UnificationXref
id: 4162623
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4162623

UnificationXref1902
type: UnificationXref
id: 4164913
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164913

UniProt:C8VV66
type: ProteinReference
xref: UnificationXref22819
organism: BioSource1

UnificationXref1908
type: UnificationXref
id: E1JIU5
db: UniProt

UnificationXref1907
type: UnificationXref
id: 4164920
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164920

UnificationXref1909
type: UnificationXref
id: 4164922
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164922

UnificationXref1904
type: UnificationXref
id: Q8WQ82
db: UniProt

UnificationXref1903
type: UnificationXref
id: 4164914
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164914

UnificationXref1906
type: UnificationXref
id: Q8WQ81
db: UniProt

UniProt:C8VV61
type: ProteinReference
xref: UnificationXref17465
organism: BioSource1

UnificationXref1905
type: UnificationXref
id: 4164918
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164918

UniProt:F3YDM6
type: ProteinReference
xref: UnificationXref26806
organism: BioSource1

http://identifiers.org/pubmed/16399380
type: PublicationXref
id: 16399380
author: Schmuck, E
author: Masoumi, A
author: Coggan, M
author: Tetlow, N
author: Board, PG
author: Whitbread, AK
db: Pubmed
title: Characterization of the omega class of glutathione transferases
source: Methods Enzymol 401:78-99
year: 2005

UniProt:C8VV79
type: ProteinReference
xref: UnificationXref28067
organism: BioSource1

UniProt:C8VV71
type: ProteinReference
xref: UnificationXref11996
organism: BioSource1

SequenceSite6081
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11114
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite6082
type: SequenceSite
position status: EQUAL
sequence position: 465

SequenceSite11113
type: SequenceSite
position status: EQUAL
sequence position: 74

SequenceSite11116
type: SequenceSite
position status: EQUAL
sequence position: 74

SequenceSite6080
type: SequenceSite
position status: EQUAL
sequence position: 437

SequenceSite11115
type: SequenceSite
position status: EQUAL
sequence position: 148

SequenceSite11118
type: SequenceSite
position status: EQUAL
sequence position: 148

SequenceSite11117
type: SequenceSite
position status: EQUAL
sequence position: 19

UniProt:C8VUZ1
type: ProteinReference
xref: UnificationXref30653
organism: BioSource1

SequenceSite11119
type: SequenceSite
position status: EQUAL
sequence position: 74

Deadenylation-dependent mRNA decay
type: Pathway
data source: Reactome
pathway component: REACT 104740.9
pathway component: REACT 29037.10
pathway component: REACT 111968.8
evidence: Evidence413
xref: UnificationXref5219
xref: UnificationXref5218
xref: RelationshipXref243
pathway order: PathwayStep401
pathway order: PathwayStep405
pathway order: PathwayStep398
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite6089
type: SequenceSite
position status: EQUAL
sequence position: 226

SequenceSite6087
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite6088
type: SequenceSite
position status: EQUAL
sequence position: 315

SequenceSite6085
type: SequenceSite
position status: EQUAL
sequence position: 111

SequenceSite6086
type: SequenceSite
position status: EQUAL
sequence position: 120

SequenceSite6083
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite6084
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref15029
type: UnificationXref
id: 4175636
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175636

UnificationXref1890
type: UnificationXref
id: Q9V3Q9
db: UniProt

UnificationXref15028
type: UnificationXref
id: REACT_144568
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144568.5

UnificationXref15027
type: UnificationXref
id: 4165388
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165388

UnificationXref1892
type: UnificationXref
id: 4157872
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4157872

UnificationXref15026
type: UnificationXref
id: 4165386
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165386

UnificationXref1891
type: UnificationXref
id: 4157871
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4157871

UnificationXref15025
type: UnificationXref
id: 4165385
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165385

UnificationXref1894
type: UnificationXref
id: 4157883
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4157883

UnificationXref15024
type: UnificationXref
id: 4165357
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165357

UnificationXref1893
type: UnificationXref
id: 4157882
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4157882

UnificationXref15023
type: UnificationXref
id: 4165356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165356

UnificationXref1896
type: UnificationXref
id: REACT_98777
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98777.9

UnificationXref15022
type: UnificationXref
id: 4165355
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165355

http://identifiers.org/pubmed/3722183
type: PublicationXref
id: 3722183
author: Fessler, JH
author: Doege, KJ
db: Pubmed
title: Folding of carboxyl domain and assembly of procollagen I
source: J Biol Chem 261:8924-35
year: 1986

UnificationXref1895
type: UnificationXref
id: 4157884
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4157884

UnificationXref15021
type: UnificationXref
id: 4165366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165366

UnificationXref1898
type: UnificationXref
id: P26308
db: UniProt

UnificationXref15020
type: UnificationXref
id: 4165365
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165365

UnificationXref1897
type: UnificationXref
id: 4164912
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164912

UnificationXref1899
type: UnificationXref
id: 4156338
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4156338

SequenceSite11110
type: SequenceSite
position status: EQUAL
sequence position: 74

SequenceSite11111
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11112
type: SequenceSite
position status: EQUAL
sequence position: 148

SequenceSite6090
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11105
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite6091
type: SequenceSite
position status: EQUAL
sequence position: 400

SequenceSite11104
type: SequenceSite
position status: EQUAL
sequence position: 74

SequenceSite6092
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite11103
type: SequenceSite
position status: EQUAL
sequence position: 148

SequenceSite6093
type: SequenceSite
position status: EQUAL
sequence position: 69

SequenceSite11102
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11109
type: SequenceSite
position status: EQUAL
sequence position: 148

SequenceSite11108
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11107
type: SequenceSite
position status: EQUAL
sequence position: 74

SequenceSite11106
type: SequenceSite
position status: EQUAL
sequence position: 148

SequenceSite6098
type: SequenceSite
position status: EQUAL
sequence position: 27

SequenceSite6099
type: SequenceSite
position status: EQUAL
sequence position: 48

SequenceSite6094
type: SequenceSite
position status: EQUAL
sequence position: 27

SequenceSite6095
type: SequenceSite
position status: EQUAL
sequence position: 50

SequenceSite6096
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite6097
type: SequenceSite
position status: EQUAL
sequence position: 48

UnificationXref15017
type: UnificationXref
id: 4165362
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165362

UniProt:F3YDH6
type: ProteinReference
xref: UnificationXref24871
organism: BioSource1

UnificationXref15016
type: UnificationXref
id: 4165361
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165361

UnificationXref15019
type: UnificationXref
id: 4165364
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165364

UnificationXref15018
type: UnificationXref
id: 4165363
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165363

UnificationXref15013
type: UnificationXref
id: 4165358
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165358

UnificationXref15012
type: UnificationXref
id: 4165369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165369

UnificationXref15015
type: UnificationXref
id: 4165360
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165360

UnificationXref15014
type: UnificationXref
id: 4165359
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165359

UnificationXref15011
type: UnificationXref
id: 4165368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165368

UnificationXref15010
type: UnificationXref
id: 4165367
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165367

SequenceSite11100
type: SequenceSite
position status: EQUAL
sequence position: 148

SequenceSite11101
type: SequenceSite
position status: EQUAL
sequence position: 74

SequenceSite11139
type: SequenceSite
position status: EQUAL
sequence position: 148

SequenceSite11136
type: SequenceSite
position status: EQUAL
sequence position: 148

SequenceSite6060
type: SequenceSite
position status: EQUAL
sequence position: 255

SequenceSite11135
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11138
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11137
type: SequenceSite
position status: EQUAL
sequence position: 74

SequenceSite6063
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite6064
type: SequenceSite
position status: EQUAL
sequence position: 465

SequenceSite6061
type: SequenceSite
position status: EQUAL
sequence position: 385

SequenceSite6062
type: SequenceSite
position status: EQUAL
sequence position: 437

SequenceSite6067
type: SequenceSite
position status: EQUAL
sequence position: 385

SequenceSite6068
type: SequenceSite
position status: EQUAL
sequence position: 437

SequenceSite6065
type: SequenceSite
position status: EQUAL
sequence position: 250

SequenceSite6066
type: SequenceSite
position status: EQUAL
sequence position: 255

UnificationXref1870
type: UnificationXref
id: 4164045
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164045

UnificationXref15048
type: UnificationXref
id: 4165248
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165248

UnificationXref15047
type: UnificationXref
id: 4165247
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165247

SequenceSite6059
type: SequenceSite
position status: EQUAL
sequence position: 250

UnificationXref1872
type: UnificationXref
id: 4164066
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164066

UnificationXref15046
type: UnificationXref
id: 4165336
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165336

SequenceSite6058
type: SequenceSite
position status: EQUAL
sequence position: 315

UnificationXref1871
type: UnificationXref
id: 4164046
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164046

UnificationXref15045
type: UnificationXref
id: 4165227
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165227

UnificationXref15049
type: UnificationXref
id: 4165249
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165249

UnificationXref1878
type: UnificationXref
id: 4157876
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4157876

UnificationXref15040
type: UnificationXref
id: MOD:01647
db: MOD

SequenceSite11131
type: SequenceSite
position status: EQUAL
sequence position: 74

UnificationXref1877
type: UnificationXref
id: Q8IN24
db: UniProt

SequenceSite11132
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11133
type: SequenceSite
position status: EQUAL
sequence position: 148

UnificationXref1879
type: UnificationXref
id: Q9BML6
db: UniProt

SequenceSite11134
type: SequenceSite
position status: EQUAL
sequence position: 74

UnificationXref1874
type: UnificationXref
id: REACT_142459
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142459.5

UnificationXref15044
type: UnificationXref
id: 4165226
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165226

UnificationXref1873
type: UnificationXref
id: 4164068
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164068

UnificationXref15043
type: UnificationXref
id: 4165224
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165224

UnificationXref1876
type: UnificationXref
id: REACT_127968
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127968.5

UnificationXref15042
type: UnificationXref
id: 4165243
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165243

UnificationXref1875
type: UnificationXref
id: 4175757
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175757

UnificationXref15041
type: UnificationXref
id: 4165242
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165242

SequenceSite11130
type: SequenceSite
position status: EQUAL
sequence position: 148

SequenceSite11129
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite11128
type: SequenceSite
position status: EQUAL
sequence position: 74

SequenceSite11127
type: SequenceSite
position status: EQUAL
sequence position: 148

SequenceSite11126
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite6070
type: SequenceSite
position status: EQUAL
sequence position: 465

SequenceSite11125
type: SequenceSite
position status: EQUAL
sequence position: 74

SequenceSite6071
type: SequenceSite
position status: EQUAL
sequence position: 250

SequenceSite11124
type: SequenceSite
position status: EQUAL
sequence position: 148

http://identifiers.org/pubmed/8709637
type: PublicationXref
id: 8709637
author: Löwenberg, B
author: Pouwels, K
author: Touw, IP
author: Hoefsloot, LH
author: van der Plas, DC
author: Smiers, F
db: Pubmed
title: Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain
source: Leukemia 10:1317-25
year: 1996

SequenceSite6072
type: SequenceSite
position status: EQUAL
sequence position: 255

SequenceSite6073
type: SequenceSite
position status: EQUAL
sequence position: 385

SequenceSite6074
type: SequenceSite
position status: EQUAL
sequence position: 437

SequenceSite6075
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite6076
type: SequenceSite
position status: EQUAL
sequence position: 465

SequenceSite6077
type: SequenceSite
position status: EQUAL
sequence position: 250

SequenceSite6078
type: SequenceSite
position status: EQUAL
sequence position: 255

SequenceSite6079
type: SequenceSite
position status: EQUAL
sequence position: 385

UnificationXref1883
type: UnificationXref
id: 4157881
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4157881

UnificationXref15035
type: UnificationXref
id: MOD:01638
db: MOD

SequenceSite6069
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1882
type: UnificationXref
id: 4157880
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4157880

UnificationXref15034
type: UnificationXref
id: 4165235
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165235

UnificationXref1881
type: UnificationXref
id: Q9Y133
db: UniProt

UnificationXref15037
type: UnificationXref
id: MOD:01631
db: MOD

UnificationXref1880
type: UnificationXref
id: 4157878
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4157878

UnificationXref15036
type: UnificationXref
id: 4165237
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165237

UnificationXref15039
type: UnificationXref
id: 4165238
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165238

UnificationXref15038
type: UnificationXref
id: MOD:01632
db: MOD

SequenceSite11122
type: SequenceSite
position status: EQUAL
sequence position: 74

SequenceSite11123
type: SequenceSite
position status: EQUAL
sequence position: 19

UnificationXref1889
type: UnificationXref
id: 4157869
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4157869

SequenceSite11120
type: SequenceSite
position status: EQUAL
sequence position: 19

UnificationXref1888
type: UnificationXref
id: D3PFE6
db: UniProt

SequenceSite11121
type: SequenceSite
position status: EQUAL
sequence position: 148

UnificationXref1887
type: UnificationXref
id: 4157867
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4157867

UnificationXref15031
type: UnificationXref
id: 4175637
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175637

UniProt:F6MIV2
type: ProteinReference
xref: UnificationXref12750
organism: BioSource1

UnificationXref1886
type: UnificationXref
id: A8WHF3
db: UniProt

UnificationXref15030
type: UnificationXref
id: REACT_147676
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147676.5

UnificationXref1885
type: UnificationXref
id: 4157865
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4157865

UnificationXref15033
type: UnificationXref
id: MOD:01641
db: MOD

UnificationXref1884
type: UnificationXref
id: Q9BML7
db: UniProt

UnificationXref15032
type: UnificationXref
id: REACT_142313
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142313.5

UniProt:F3YDD9
type: ProteinReference
xref: UnificationXref13954
organism: BioSource1

SequenceSite11157
type: SequenceSite
position status: EQUAL
sequence position: 244

UnificationXref1859
type: UnificationXref
id: 4164059
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164059

SequenceSite11158
type: SequenceSite
position status: EQUAL
sequence position: 266

SequenceSite11159
type: SequenceSite
position status: EQUAL
sequence position: 244

UnificationXref1851
type: UnificationXref
id: E1JJA9
db: UniProt

UnificationXref15065
type: UnificationXref
id: 4165255
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165255

SequenceSite11150
type: SequenceSite
position status: EQUAL
sequence position: 19

UnificationXref1852
type: UnificationXref
id: 4164050
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164050

UnificationXref15066
type: UnificationXref
id: 4165256
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165256

UnificationXref1853
type: UnificationXref
id: Q24352
db: UniProt

UnificationXref15063
type: UnificationXref
id: 4165253
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165253

SequenceSite11152
type: SequenceSite
position status: EQUAL
sequence position: 74

UnificationXref1854
type: UnificationXref
id: 4164054
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164054

UnificationXref15064
type: UnificationXref
id: 4165254
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165254

SequenceSite11151
type: SequenceSite
position status: EQUAL
sequence position: 148

UnificationXref1855
type: UnificationXref
id: Q9VXL9
db: UniProt

UnificationXref15061
type: UnificationXref
id: 4165251
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165251

SequenceSite11154
type: SequenceSite
position status: EQUAL
sequence position: 148

UnificationXref1856
type: UnificationXref
id: 4164056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164056

UnificationXref15062
type: UnificationXref
id: 4165252
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165252

SequenceSite11153
type: SequenceSite
position status: EQUAL
sequence position: 19

UnificationXref1857
type: UnificationXref
id: Q4V4W7
db: UniProt

SequenceSite11156
type: SequenceSite
position status: EQUAL
sequence position: 266

UnificationXref1858
type: UnificationXref
id: 4164058
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164058

UnificationXref15060
type: UnificationXref
id: REACT_159495
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159495.3

SequenceSite11155
type: SequenceSite
position status: EQUAL
sequence position: 244

UnificationXref15069
type: UnificationXref
id: 4165259
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165259

UnificationXref15067
type: UnificationXref
id: 4165257
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165257

UnificationXref1850
type: UnificationXref
id: REACT_132875
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132875.5

UnificationXref15068
type: UnificationXref
id: 4165258
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165258

SequenceSite11148
type: SequenceSite
position status: EQUAL
sequence position: 148

SequenceSite11149
type: SequenceSite
position status: EQUAL
sequence position: 74

SequenceSite11146
type: SequenceSite
position status: EQUAL
sequence position: 74

SequenceSite11147
type: SequenceSite
position status: EQUAL
sequence position: 19

UnificationXref1864
type: UnificationXref
id: 4164064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164064

UnificationXref15052
type: UnificationXref
id: 4165234
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165234

SequenceSite11141
type: SequenceSite
position status: EQUAL
sequence position: 19

UnificationXref1865
type: UnificationXref
id: 4164065
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164065

UnificationXref15053
type: UnificationXref
id: 4165244
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165244

SequenceSite11140
type: SequenceSite
position status: EQUAL
sequence position: 74

UnificationXref1862
type: UnificationXref
id: 4164062
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164062

UnificationXref15054
type: UnificationXref
id: 4165245
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165245

UnificationXref1863
type: UnificationXref
id: 4164063
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164063

UnificationXref15055
type: UnificationXref
id: 4165246
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165246

UnificationXref1868
type: UnificationXref
id: 4164043
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164043

SequenceSite11145
type: SequenceSite
position status: EQUAL
sequence position: 148

UnificationXref1869
type: UnificationXref
id: 4164044
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164044

SequenceSite11144
type: SequenceSite
position status: EQUAL
sequence position: 19

UnificationXref1866
type: UnificationXref
id: 4164039
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164039

UnificationXref15050
type: UnificationXref
id: 4165337
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165337

SequenceSite11143
type: SequenceSite
position status: EQUAL
sequence position: 74

UnificationXref1867
type: UnificationXref
id: Q08832
db: UniProt

UnificationXref15051
type: UnificationXref
id: REACT_154202
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154202.3

SequenceSite11142
type: SequenceSite
position status: EQUAL
sequence position: 148

UniProt:F3YDD4
type: ProteinReference
xref: UnificationXref23116
organism: BioSource1

UnificationXref1860
type: UnificationXref
id: 4164060
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164060

UnificationXref15056
type: UnificationXref
id: 4165348
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165348

UnificationXref1861
type: UnificationXref
id: 4164061
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164061

UnificationXref15057
type: UnificationXref
id: REACT_128968
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128968.5

UnificationXref15058
type: UnificationXref
id: 4165250
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165250

UnificationXref15059
type: UnificationXref
id: 4165349
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165349

UnificationXref1838
type: UnificationXref
id: 4160777
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160777

UnificationXref15091
type: UnificationXref
id: 4165797
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165797

SequenceSite11179
type: SequenceSite
position status: EQUAL
sequence position: 585

UnificationXref1837
type: UnificationXref
id: 4160775
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160775

UnificationXref15090
type: UnificationXref
id: 4165393
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165393

http://identifiers.org/pubmed/18215623
type: PublicationXref
id: 18215623
author: Lustig, LR
author: Edwards, RH
author: Glowatzki, E
author: Grant, L
author: Weber, CM
author: Clause, A
author: Yoo, J
author: Noebels, JL
author: Seal, RP
author: Akil, O
author: Yi, E
author: Kandler, K
db: Pubmed
title: Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3
source: Neuron 57:263-75
year: 2008

UnificationXref1839
type: UnificationXref
id: 4160779
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160779

UnificationXref1833
type: UnificationXref
id: 4160767
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160767

UnificationXref15083
type: UnificationXref
id: 4165793
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165793

SequenceSite11176
type: SequenceSite
position status: EQUAL
sequence position: 914

UnificationXref1834
type: UnificationXref
id: 4160769
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160769

UnificationXref15084
type: UnificationXref
id: REACT_153333
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153333.3

SequenceSite11175
type: SequenceSite
position status: EQUAL
sequence position: 913

UnificationXref1835
type: UnificationXref
id: 4160771
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160771

UnificationXref15081
type: UnificationXref
id: 4165791
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165791

SequenceSite11178
type: SequenceSite
position status: EQUAL
sequence position: 913

UnificationXref1836
type: UnificationXref
id: 4160773
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160773

UnificationXref15082
type: UnificationXref
id: 4165792
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165792

SequenceSite11177
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref15087
type: UnificationXref
id: REACT_157496
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157496.3

SequenceSite11172
type: SequenceSite
position status: EQUAL
sequence position: 913

UnificationXref1830
type: UnificationXref
id: 4160761
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160761

UnificationXref15088
type: UnificationXref
id: 4165391
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165391

SequenceSite11171
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1831
type: UnificationXref
id: 4160763
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160763

UnificationXref15085
type: UnificationXref
id: 4165794
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165794

SequenceSite11174
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9050246
type: PublicationXref
id: 9050246
author: Nikinmaa, M
db: Pubmed
title: Oxygen and carbon dioxide transport in vertebrate erythrocytes: an evolutionary change in the role of membrane transport
source: J Exp Biol 200:369-80
year: 1997

UnificationXref1832
type: UnificationXref
id: 4160765
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160765

UnificationXref15086
type: UnificationXref
id: 4165795
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165795

SequenceSite11173
type: SequenceSite
position status: EQUAL
sequence position: 914

UniProt:F3YDG3
type: ProteinReference
xref: UnificationXref7967
organism: BioSource1

UnificationXref15089
type: UnificationXref
id: 4165392
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165392

SequenceSite11170
type: SequenceSite
position status: EQUAL
sequence position: 914

UniProt:F3YDG6
type: ProteinReference
xref: UnificationXref7969
organism: BioSource1

UnificationXref1849
type: UnificationXref
id: 4175710
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175710

UnificationXref15080
type: UnificationXref
id: REACT_137141
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137141.5

SequenceSite11168
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1848
type: UnificationXref
id: REACT_143784
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143784.5

SequenceSite11169
type: SequenceSite
position status: EQUAL
sequence position: 913

UnificationXref1846
type: UnificationXref
id: REACT_129423
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129423.5

UnificationXref15070
type: UnificationXref
id: 4165260
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165260

SequenceSite11167
type: SequenceSite
position status: EQUAL
sequence position: 914

UnificationXref1847
type: UnificationXref
id: 4175713
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175713

UnificationXref15071
type: UnificationXref
id: 4165261
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165261

SequenceSite11166
type: SequenceSite
position status: EQUAL
sequence position: 913

UnificationXref1844
type: UnificationXref
id: 4161635
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161635

UnificationXref15072
type: UnificationXref
id: 4165262
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165262

SequenceSite11165
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1845
type: UnificationXref
id: 4161636
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161636

UnificationXref15073
type: UnificationXref
id: 4165263
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165263

SequenceSite11164
type: SequenceSite
position status: EQUAL
sequence position: 914

UnificationXref1842
type: UnificationXref
id: 4160784
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160784

UnificationXref15074
type: UnificationXref
id: 4165264
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165264

SequenceSite11163
type: SequenceSite
position status: EQUAL
sequence position: 913

UnificationXref1843
type: UnificationXref
id: 4160785
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160785

UnificationXref15075
type: UnificationXref
id: 4165265
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165265

SequenceSite11162
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1840
type: UnificationXref
id: 4160781
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160781

UnificationXref15076
type: UnificationXref
id: 4165266
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165266

SequenceSite11161
type: SequenceSite
position status: EQUAL
sequence position: 914

UnificationXref1841
type: UnificationXref
id: 4160783
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160783

UnificationXref15077
type: UnificationXref
id: 4165267
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165267

SequenceSite11160
type: SequenceSite
position status: EQUAL
sequence position: 266

UnificationXref15078
type: UnificationXref
id: 4165268
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165268

http://identifiers.org/pubmed/15167709
type: PublicationXref
id: 15167709
author: Blanchard, RL
author: Buck, J
author: Freimuth, RR
author: Coughtrie, MW
author: Weinshilboum, RM
db: Pubmed
title: A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily
source: Pharmacogenetics 14:199-211
year: 2004

UnificationXref15079
type: UnificationXref
id: 4165270
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165270

SequenceSite11191
type: SequenceSite
position status: EQUAL
sequence position: 585

SequenceSite11192
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11190
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11195
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11196
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11193
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11194
type: SequenceSite
position status: EQUAL
sequence position: 585

SequenceSite11199
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11197
type: SequenceSite
position status: EQUAL
sequence position: 585

SequenceSite11198
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite937
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite938
type: SequenceSite
position status: EQUAL
sequence position: 740

SequenceSite935
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite936
type: SequenceSite
position status: EQUAL
sequence position: 733

SequenceSite939
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite6000
type: SequenceSite
position status: EQUAL
sequence position: 1290

SequenceSite930
type: SequenceSite
position status: EQUAL
sequence position: 735

SequenceSite6001
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite6002
type: SequenceSite
position status: EQUAL
sequence position: 1290

SequenceSite933
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite934
type: SequenceSite
position status: EQUAL
sequence position: 733

SequenceSite931
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite932
type: SequenceSite
position status: EQUAL
sequence position: 733

SequenceSite6009
type: SequenceSite
position status: EQUAL
sequence position: 156

SequenceSite6008
type: SequenceSite
position status: EQUAL
sequence position: 583

SequenceSite6007
type: SequenceSite
position status: EQUAL
sequence position: 156

SequenceSite6006
type: SequenceSite
position status: EQUAL
sequence position: 583

SequenceSite6005
type: SequenceSite
position status: EQUAL
sequence position: 156

SequenceSite6004
type: SequenceSite
position status: EQUAL
sequence position: 1290

SequenceSite11180
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite6003
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite11181
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11182
type: SequenceSite
position status: EQUAL
sequence position: 585

SequenceSite11183
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11184
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11185
type: SequenceSite
position status: EQUAL
sequence position: 585

SequenceSite11186
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11187
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11188
type: SequenceSite
position status: EQUAL
sequence position: 585

SequenceSite11189
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite946
type: SequenceSite
position status: EQUAL
sequence position: 745

SequenceSite947
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite948
type: SequenceSite
position status: EQUAL
sequence position: 745

SequenceSite949
type: SequenceSite
position status: EQUAL
sequence position: 363

SequenceSite6012
type: SequenceSite
position status: EQUAL
sequence position: 583

SequenceSite6013
type: SequenceSite
position status: EQUAL
sequence position: 111

SequenceSite6010
type: SequenceSite
position status: EQUAL
sequence position: 583

SequenceSite940
type: SequenceSite
position status: EQUAL
sequence position: 740

SequenceSite6011
type: SequenceSite
position status: EQUAL
sequence position: 111

SequenceSite941
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite942
type: SequenceSite
position status: EQUAL
sequence position: 740

G2/M DNA damage checkpoint
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction2289
pathway component: REACT 77140.9
evidence: Evidence3349
xref: UnificationXref32207
xref: UnificationXref32208
pathway order: PathwayStep3334
pathway order: PathwayStep3329
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite943
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite944
type: SequenceSite
position status: EQUAL
sequence position: 745

SequenceSite945
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite919
type: SequenceSite
position status: EQUAL
sequence position: 185

SequenceSite917
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite918
type: SequenceSite
position status: EQUAL
sequence position: 360

SequenceSite915
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite916
type: SequenceSite
position status: EQUAL
sequence position: 766

SequenceSite913
type: SequenceSite
position status: EQUAL
sequence position: 766

SequenceSite914
type: SequenceSite
position status: EQUAL
sequence position: 338

http://identifiers.org/pubmed/18048764
type: PublicationXref
id: 18048764
author: Eizirik, DL
author: Cnop, M
author: Cardozo, AK
db: Pubmed
title: The role for endoplasmic reticulum stress in diabetes mellitus
source: Endocr Rev 29:42-61
year: 2008

SequenceSite911
type: SequenceSite
position status: EQUAL
sequence position: 215

SequenceSite912
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite910
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:F3YDB9
type: ProteinReference
xref: UnificationXref6253
organism: BioSource1

http://identifiers.org/pubmed/16543958
type: PublicationXref
id: 16543958
author: Hirsch, E
author: Rommel, C
author: Barberis, L
author: Montrucchio, G
author: Lembo, G
author: Costa, C
db: Pubmed
title: Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing
source: Thromb Haemost 95:29-35
year: 2006

SequenceSite928
type: SequenceSite
position status: EQUAL
sequence position: 735

SequenceSite929
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite924
type: SequenceSite
position status: EQUAL
sequence position: 648

SequenceSite925
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite926
type: SequenceSite
position status: EQUAL
sequence position: 735

SequenceSite927
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite920
type: SequenceSite
position status: EQUAL
sequence position: 187

SequenceSite921
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite922
type: SequenceSite
position status: EQUAL
sequence position: 360

SequenceSite923
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite6036
type: SequenceSite
position status: EQUAL
sequence position: 583

SequenceSite6037
type: SequenceSite
position status: EQUAL
sequence position: 239

SequenceSite6038
type: SequenceSite
position status: EQUAL
sequence position: 240

SequenceSite6039
type: SequenceSite
position status: EQUAL
sequence position: 317

SequenceSite6044
type: SequenceSite
position status: EQUAL
sequence position: 317

SequenceSite6043
type: SequenceSite
position status: EQUAL
sequence position: 240

SequenceSite6046
type: SequenceSite
position status: EQUAL
sequence position: 583

SequenceSite6045
type: SequenceSite
position status: EQUAL
sequence position: 111

SequenceSite6040
type: SequenceSite
position status: EQUAL
sequence position: 111

SequenceSite6042
type: SequenceSite
position status: EQUAL
sequence position: 239

SequenceSite6041
type: SequenceSite
position status: EQUAL
sequence position: 583

SequenceSite6049
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite6047
type: SequenceSite
position status: EQUAL
sequence position: 112

SequenceSite6048
type: SequenceSite
position status: EQUAL
sequence position: 115

monomethylated residue
type: SequenceModificationVocabulary
xref: UnificationXref3844

SequenceSite6057
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite6056
type: SequenceSite
position status: EQUAL
sequence position: 121

SequenceSite6055
type: SequenceSite
position status: EQUAL
sequence position: -315

SequenceSite6054
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite6053
type: SequenceSite
position status: EQUAL
sequence position: 315

SequenceSite6052
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite6051
type: SequenceSite
position status: EQUAL
sequence position: 227

SequenceSite901
type: SequenceSite
position status: EQUAL
sequence position: 880

SequenceSite6050
type: SequenceSite
position status: EQUAL
sequence position: 315

SequenceSite900
type: SequenceSite
position status: EQUAL
sequence position: 883

SequenceSite903
type: SequenceSite
position status: EQUAL
sequence position: 883

SequenceSite902
type: SequenceSite
position status: EQUAL
sequence position: 25

SequenceSite905
type: SequenceSite
position status: EQUAL
sequence position: 25

SequenceSite904
type: SequenceSite
position status: EQUAL
sequence position: 880

SequenceSite907
type: SequenceSite
position status: EQUAL
sequence position: 880

SequenceSite906
type: SequenceSite
position status: EQUAL
sequence position: 883

SequenceSite909
type: SequenceSite
position status: EQUAL
sequence position: 883

SequenceSite908
type: SequenceSite
position status: EQUAL
sequence position: 25

UnificationXref15000
type: UnificationXref
id: 4165380
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165380

SequenceSite6014
type: SequenceSite
position status: EQUAL
sequence position: 583

UnificationXref15001
type: UnificationXref
id: 4165381
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165381

SequenceSite6015
type: SequenceSite
position status: EQUAL
sequence position: 111

UnificationXref15002
type: UnificationXref
id: 4165382
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165382

SequenceSite6016
type: SequenceSite
position status: EQUAL
sequence position: 583

UnificationXref15003
type: UnificationXref
id: 4165383
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165383

SequenceSite6017
type: SequenceSite
position status: EQUAL
sequence position: 194

UnificationXref15004
type: UnificationXref
id: 4165384
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165384

SequenceSite6018
type: SequenceSite
position status: EQUAL
sequence position: 195

UnificationXref15005
type: UnificationXref
id: 4165353
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165353

SequenceSite6019
type: SequenceSite
position status: EQUAL
sequence position: 272

UnificationXref15006
type: UnificationXref
id: 4165351
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165351

UnificationXref15007
type: UnificationXref
id: 4165350
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165350

UnificationXref15008
type: UnificationXref
id: 4165352
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165352

UnificationXref15009
type: UnificationXref
id: 4165354
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4165354

http://identifiers.org/pubmed/20869317
type: PublicationXref
id: 20869317
author: Shastri, N
author: Blanchard, N
db: Pubmed
title: Topological journey of parasite-derived antigens for presentation by MHC class I molecules
source: Trends Immunol 31:414-21
year: 2010

SequenceSite6020
type: SequenceSite
position status: EQUAL
sequence position: 156

SequenceSite6022
type: SequenceSite
position status: EQUAL
sequence position: 194

SequenceSite6021
type: SequenceSite
position status: EQUAL
sequence position: 583

SequenceSite6024
type: SequenceSite
position status: EQUAL
sequence position: 272

SequenceSite6023
type: SequenceSite
position status: EQUAL
sequence position: 195

SequenceSite6027
type: SequenceSite
position status: EQUAL
sequence position: 194

SequenceSite6028
type: SequenceSite
position status: EQUAL
sequence position: 195

SequenceSite6025
type: SequenceSite
position status: EQUAL
sequence position: 156

SequenceSite6026
type: SequenceSite
position status: EQUAL
sequence position: 583

SequenceSite6029
type: SequenceSite
position status: EQUAL
sequence position: 272

SequenceSite6031
type: SequenceSite
position status: EQUAL
sequence position: 583

SequenceSite6030
type: SequenceSite
position status: EQUAL
sequence position: 156

SequenceSite6035
type: SequenceSite
position status: EQUAL
sequence position: 111

SequenceSite6034
type: SequenceSite
position status: EQUAL
sequence position: 317

SequenceSite6033
type: SequenceSite
position status: EQUAL
sequence position: 240

SequenceSite6032
type: SequenceSite
position status: EQUAL
sequence position: 239

SequenceSite885
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite886
type: SequenceSite
position status: EQUAL
sequence position: 697

SequenceSite883
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite884
type: SequenceSite
position status: EQUAL
sequence position: 671

SequenceSite889
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite887
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite888
type: SequenceSite
position status: EQUAL
sequence position: 697

UniProt:B3DND5
type: ProteinReference
xref: UnificationXref6201
organism: BioSource1

http://identifiers.org/pubmed/19273840
type: PublicationXref
id: 19273840
author: Chen, LM
author: Pelletier, MF
author: Musa-Aziz, R
author: Boron, WF
db: Pubmed
title: Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG
source: Proc Natl Acad Sci U S A 106:5406-11
year: 2009

SequenceSite882
type: SequenceSite
position status: EQUAL
sequence position: 671

SequenceSite881
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite880
type: SequenceSite
position status: EQUAL
sequence position: 672

SequenceSite872
type: SequenceSite
position status: EQUAL
sequence position: 906

SequenceSite873
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite874
type: SequenceSite
position status: EQUAL
sequence position: 906

SequenceSite875
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite876
type: SequenceSite
position status: EQUAL
sequence position: 906

http://identifiers.org/pubmed/11101851
type: PublicationXref
id: 11101851
author: Artavanis-Tsakonas, S
author: Blacklow, SC
author: Griffin, JD
author: Aster, JC
author: Wu, L
author: Lake, R
db: Pubmed
title: MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
source: Nat Genet 26:484-9
year: 2000

SequenceSite877
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite878
type: SequenceSite
position status: EQUAL
sequence position: 672

SequenceSite879
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/10582339
type: PublicationXref
id: 10582339
author: Linnekin, D
db: Pubmed
title: Early signaling pathways activated by c-Kit in hematopoietic cells
source: Int J Biochem Cell Biol 31:1053-74
year: 1999

http://identifiers.org/pubmed/6696436
type: PublicationXref
id: 6696436
author: Freemont, PS
author: Fothergill, LA
author: Dunbar, B
db: Pubmed
title: Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments
source: Arch Biochem Biophys 228:342-52
year: 1984

SequenceSite871
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite870
type: SequenceSite
position status: EQUAL
sequence position: 906

SequenceSite898
type: SequenceSite
position status: EQUAL
sequence position: 880

SequenceSite899
type: SequenceSite
position status: EQUAL
sequence position: 25

Evidence900
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9733710
xref: http://identifiers.org/pubmed/9528766
xref: http://identifiers.org/pubmed/9297626
comment: NGF induces sustained activation of p38, a member of the MAPK family (Morooka T, Nishida E, 1998). Both p38 and the ERKs appear to be involved in neurite outgrowth and differentiation caused by NGF in PC12 cells. As a matter of fact, PC12 cell differentiation appears to involve activation of both ERK/MAPK and p38. Both ERK/MAPK and p38 pathways contribute to the phosphorylation of the transcription factor CREB and the activation of immediate-early genes (Xing J, 1998). p38 activation by NGF may occur by at least two mechanisms, involving SRC or MEK kinases.

SequenceSite894
type: SequenceSite
position status: EQUAL
sequence position: 744

SequenceSite895
type: SequenceSite
position status: EQUAL
sequence position: 880

SequenceSite896
type: SequenceSite
position status: EQUAL
sequence position: 25

SequenceSite897
type: SequenceSite
position status: EQUAL
sequence position: 883

Evidence905
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9069267
comment: ARMS (Ankyrin-Rich Membrane Spanning/Kidins 220) is a 220kD tetraspanning adaptor protein which becomes rapidly tyrosine phosphorylated by active Trk receptors. ARMS is another adaptor protein which is involved in the activation of Rap1 and the subsequent prolonged activation of the MAPK cascade.

Evidence906
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9069267
xref: http://identifiers.org/pubmed/12765839
comment: After NGF binding, activated Trk receptors provide multiple docking sites for adaptor proteins and enzymes. Two docking proteins, the Ankyrin-Rich Membrane Spanning protein (ARMS/Kidins220) and Fibroblast growth factor receptor substrate 2 (Frs2), target signaling molecules in response to NGF stimulation and link receptor activation with the MAP kinase (also called the Extracellular signal-Regulated Kinase cascade, ERK) cascade, an essential process for growth factor-induced cell proliferation and differentiation. A feature of NGF signaling is the sustained activation of the MAPK cascade. This is achieved by the small G protein, Rap1 which binds to and activates B-Raf, an activator of the MAPK cascade. Rap1 is a member of the Ras family of G proteins and like all G proteins, Rap1 is in an inactive state when bound to GDP and is active when bound to GTP. A specific GEF (guanine nucleotide exchange factor) called C3G can activate Rap1 by exchanging GDP for GTP.

Evidence907
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10508738
comment: Neurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS, ocurring from caveolae in the plasma membrane or from clathrin-coated vesicles, and via RAP1, taking place in early endosomes. Whereas RAS activation by NGF is transient, RAP1 activation by NGF is sustained for hours.

Evidence908
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10579907
xref: PublicationXref1180
comment: The activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosphorylation by TrkA receptor kinase and this form hydrolyses PIP2 to generate inositol tris-phosphate (IP3) and diacylglycerol (DAG). IP3 promotes the release of Ca2+ from internal stores and this results in activation of enzymes such as protein kinase C and Ca2+ calmodulin-regulated protein kinases.

Evidence901
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11520933
comment: Signalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation of MAPK found in NGF-treated cells.

Evidence902
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10712923
comment: RIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT and RIN lack a typical prenylation motif (CAAX, XXCC, or CXC) required for the association of RAS proteins with the plasma membrane. RIT is expressed in all tissues, whereas RIN is neuron-specific. They have similar signalling properties and are activated by NGF through unknown exchange factors. They signal to ERKs and p38 MAP kinase. They mainly lead to p38 activation via the BRAF-MEK kinase cascade.

Evidence903
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Rap1 binds to B-RAF; as a consequence, B-RAF is recruited to endosomes. The binding event of Rap1 to B-RAF is thought to be very similar to the binding of RAS to RAF-1. In neuronal cells that express B-Raf, NGF induced activation of Rap1 promotes a sustained activation of ERKs and is required for the induction of electrical excitability and a subset of neuron-specific genes. As regards morphological differentiation (e. g. neurite outgrowth in PC12 cells), things are more complex. The transient activation of ERKs via RAS is not sufficient for neurite outgrowth in the absence of additional signals. On the contrary, constitutive activation of Rap1 is sufficient to trigger neurite outgrowth, but it is not necessary for this response. Clearly, morphological differentiation of PC12 cells involves the activation of multiple pathways by NGF. Rap1 activates B-Raf, but inhibits RAF-1. Consequently, Rap1 could have two opposing functions: to limit ERK activation in B-RAF-negative cells and to increase ERK activation in B-Raf-positive cells.

Evidence904
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9069267
comment: The adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.

Evidence909
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Several guanine exchange factors (GEFs) for the Rho family of GTPases contain PH domains that bind to PIP3. RhoA protein activation is a mechanism whereby PI3K acts independently of AKT.

http://identifiers.org/pubmed/12450384
type: PublicationXref
id: 12450384
author: Zhang, Y
author: Desharnais, J
author: Beardsley, GP
author: Wilson, IA
author: Greasley, SE
author: Boger, DL
db: Pubmed
title: Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR
source: Biochemistry 41:14206-14215
year: 2002

SequenceSite891
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite890
type: SequenceSite
position status: EQUAL
sequence position: 744

SequenceSite893
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite892
type: SequenceSite
position status: EQUAL
sequence position: 744

SequenceSite849
type: SequenceSite
position status: EQUAL
sequence position: 29

SequenceSite848
type: SequenceSite
position status: EQUAL
sequence position: 894

SequenceSite847
type: SequenceSite
position status: EQUAL
sequence position: 29

SequenceSite842
type: SequenceSite
position status: EQUAL
sequence position: 883

SequenceSite841
type: SequenceSite
position status: EQUAL
sequence position: 25

SequenceSite840
type: SequenceSite
position status: EQUAL
sequence position: 883

SequenceSite846
type: SequenceSite
position status: EQUAL
sequence position: 883

SequenceSite845
type: SequenceSite
position status: EQUAL
sequence position: 25

SequenceSite844
type: SequenceSite
position status: EQUAL
sequence position: 883

SequenceSite843
type: SequenceSite
position status: EQUAL
sequence position: 25

http://identifiers.org/pubmed/19303758
type: PublicationXref
id: 19303758
author: Hemmings, BA
author: Bozulic, L
db: Pubmed
title: PIKKing on PKB: regulation of PKB activity by phosphorylation
source: Curr Opin Cell Biol 21:256-61
year: 2009

SequenceSite837
type: SequenceSite
position status: EQUAL
sequence position: 25

SequenceSite836
type: SequenceSite
position status: EQUAL
sequence position: 1128

SequenceSite839
type: SequenceSite
position status: EQUAL
sequence position: 25

SequenceSite838
type: SequenceSite
position status: EQUAL
sequence position: 883

SequenceSite831
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite830
type: SequenceSite
position status: EQUAL
sequence position: 415

http://identifiers.org/pubmed/8787677
type: PublicationXref
id: 8787677
author: Schuster, VL
author: Kanai, N
author: Lu, R
author: Bao, Y
db: Pubmed
title: Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT)
source: J Clin Invest 98:1142-9
year: 1996

SequenceSite833
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite832
type: SequenceSite
position status: EQUAL
sequence position: 415

SequenceSite835
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite834
type: SequenceSite
position status: EQUAL
sequence position: 1128

http://identifiers.org/pubmed/15809071
type: PublicationXref
id: 15809071
author: Ishibashi, K
author: Uchida, S
author: Ko, SB
author: Sasaki, S
author: Kuwahara, M
author: Rai, T
author: Itoh, T
db: Pubmed
title: Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells
source: Biochem Biophys Res Commun 330:832-8
year: 2005

SequenceSite869
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite868
type: SequenceSite
position status: EQUAL
sequence position: 906

SequenceSite867
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite866
type: SequenceSite
position status: EQUAL
sequence position: 902

SequenceSite865
type: SequenceSite
position status: EQUAL
sequence position: 21

SequenceSite864
type: SequenceSite
position status: EQUAL
sequence position: 902

SequenceSite863
type: SequenceSite
position status: EQUAL
sequence position: 21

SequenceSite862
type: SequenceSite
position status: EQUAL
sequence position: 902

SequenceSite861
type: SequenceSite
position status: EQUAL
sequence position: 21

SequenceSite860
type: SequenceSite
position status: EQUAL
sequence position: 902

http://identifiers.org/pubmed/11684289
type: PublicationXref
id: 11684289
author: Villadangos, JA
db: Pubmed
title: Presentation of antigens by MHC class II molecules: getting the most out of them
source: Mol Immunol 38:329-46
year: 2001

SequenceSite859
type: SequenceSite
position status: EQUAL
sequence position: 21

SequenceSite858
type: SequenceSite
position status: EQUAL
sequence position: 902

SequenceSite855
type: SequenceSite
position status: EQUAL
sequence position: 29

SequenceSite854
type: SequenceSite
position status: EQUAL
sequence position: 894

SequenceSite857
type: SequenceSite
position status: EQUAL
sequence position: 21

SequenceSite856
type: SequenceSite
position status: EQUAL
sequence position: 894

SequenceSite851
type: SequenceSite
position status: EQUAL
sequence position: 29

SequenceSite850
type: SequenceSite
position status: EQUAL
sequence position: 894

SequenceSite853
type: SequenceSite
position status: EQUAL
sequence position: 29

SequenceSite852
type: SequenceSite
position status: EQUAL
sequence position: 894

Platelet degranulation
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction1155
pathway component: BiochemicalReaction1150
pathway component: BiochemicalReaction1151
pathway component: BiochemicalReaction1156
pathway component: BiochemicalReaction1157
pathway component: BiochemicalReaction1153
pathway component: BiochemicalReaction1154
pathway component: BiochemicalReaction1152
evidence: Evidence1788
xref: RelationshipXref884
xref: UnificationXref18054
xref: UnificationXref18053
pathway order: PathwayStep1775
pathway order: PathwayStep1774
pathway order: PathwayStep1778
pathway order: PathwayStep1777
pathway order: PathwayStep1781
pathway order: PathwayStep1776
pathway order: PathwayStep1779
pathway order: PathwayStep1780
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1801
type: UnificationXref
id: 4160966
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160966

UnificationXref1800
type: UnificationXref
id: 4160965
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160965

UnificationXref1803
type: UnificationXref
id: 4161081
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161081

UnificationXref1802
type: UnificationXref
id: 4161080
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161080

UnificationXref1804
type: UnificationXref
id: 4161083
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161083

UnificationXref1805
type: UnificationXref
id: 4161084
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161084

UnificationXref1806
type: UnificationXref
id: 4161085
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161085

UnificationXref1807
type: UnificationXref
id: REACT_147499
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147499.5

UnificationXref1808
type: UnificationXref
id: 4161087
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161087

UnificationXref1809
type: UnificationXref
id: REACT_142339
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142339.5

UniProt:Q05652
type: ProteinReference
xref: UnificationXref14692
organism: BioSource1

UniProt:B3DNL5
type: ProteinReference
xref: UnificationXref21750
organism: BioSource1

UnificationXref1823
type: UnificationXref
id: 4160741
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160741

UnificationXref1822
type: UnificationXref
id: 4160739
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160739

UnificationXref1825
type: UnificationXref
id: 4160747
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160747

UnificationXref1824
type: UnificationXref
id: 4160743
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160743

UnificationXref1821
type: UnificationXref
id: 4160735
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160735

UnificationXref1820
type: UnificationXref
id: 4160733
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160733

UnificationXref1826
type: UnificationXref
id: 4160751
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160751

UnificationXref1827
type: UnificationXref
id: 4160753
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160753

UnificationXref1828
type: UnificationXref
id: 4160757
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160757

UnificationXref1829
type: UnificationXref
id: 4160759
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160759

UnificationXref1814
type: UnificationXref
id: 4160711
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160711

UnificationXref1813
type: UnificationXref
id: REACT_140410
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140410.5

UnificationXref1812
type: UnificationXref
id: 4175709
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175709

UnificationXref1811
type: UnificationXref
id: REACT_129531
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129531.5

UnificationXref1810
type: UnificationXref
id: 4175708
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175708

http://identifiers.org/pubmed/17296555
type: PublicationXref
id: 17296555
author: Komai, S
author: Kiyama, Y
author: Mizuno, H
author: Mitchell, KJ
author: Fujisawa, H
author: Kamiya, H
author: Manabe, T
author: Chédotal, A
author: Yagi, T
author: Hiromi, Y
author: Shimizu, M
author: Tsuboi, M
author: Sanbo, M
author: Suto, F
db: Pubmed
title: Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers
source: Neuron 53:535-47
year: 2007

UnificationXref1819
type: UnificationXref
id: 4160731
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160731

UnificationXref1817
type: UnificationXref
id: 4160723
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160723

UnificationXref1818
type: UnificationXref
id: 4160727
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160727

UnificationXref1815
type: UnificationXref
id: 4160715
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160715

UnificationXref1816
type: UnificationXref
id: 4160719
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160719

http://identifiers.org/pubmed/3539386
type: PublicationXref
id: 3539386
author: Wood, T
db: Pubmed
title: Physiological functions of the pentose phosphate pathway
source: Cell Biochem Funct 4:241-7
year: 1986

SequenceSite11200
type: SequenceSite
position status: EQUAL
sequence position: 585

SequenceSite11201
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11202
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11203
type: SequenceSite
position status: EQUAL
sequence position: 585

SequenceSite11204
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11205
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11206
type: SequenceSite
position status: EQUAL
sequence position: 585

SequenceSite11207
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11208
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11209
type: SequenceSite
position status: EQUAL
sequence position: 585

SequenceSite11211
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11210
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11214
type: SequenceSite
position status: EQUAL
sequence position: 132

SequenceSite11215
type: SequenceSite
position status: EQUAL
sequence position: 340

SequenceSite11212
type: SequenceSite
position status: EQUAL
sequence position: 133

SequenceSite11213
type: SequenceSite
position status: EQUAL
sequence position: 1

Eukaryotic Translation Termination
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction342
pathway component: BiochemicalReaction343
pathway component: BiochemicalReaction341
evidence: Evidence502
xref: RelationshipXref282
xref: UnificationXref5940
xref: UnificationXref5939
pathway order: PathwayStep493
pathway order: PathwayStep492
pathway order: PathwayStep494
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11222639
type: PublicationXref
id: 11222639
author: Maness, PF
author: Thelen, K
author: Needham, LK
db: Pubmed
title: Cytoplasmic domain mutations of the L1 cell adhesion molecule reduce L1-ankyrin interactions
source: J Neurosci 21:1490-500
year: 2001

SequenceSite11218
type: SequenceSite
position status: EQUAL
sequence position: 627

SequenceSite11219
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11216
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11217
type: SequenceSite
position status: EQUAL
sequence position: 339

http://identifiers.org/pubmed/18678926
type: PublicationXref
id: 18678926
author: Rajnarayanan, RV
author: Cohly, HH
author: Isokpehi, R
db: Pubmed
title: Compartmentalization of aquaporins in the human intestine
source: Int J Environ Res Public Health 5:115-9
year: 2008

SequenceSite11257
type: SequenceSite
position status: EQUAL
sequence position: 766

SequenceSite11256
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11259
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11258
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1757
type: UnificationXref
id: Q0KI38
db: UniProt

SequenceSite11252
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1756
type: UnificationXref
id: 4161050
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161050

SequenceSite11253
type: SequenceSite
position status: EQUAL
sequence position: 584

UnificationXref1759
type: UnificationXref
id: Q8MQM7
db: UniProt

SequenceSite11254
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1758
type: UnificationXref
id: 4161054
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161054

SequenceSite11255
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1753
type: UnificationXref
id: Q9VIE2
db: UniProt

UnificationXref1752
type: UnificationXref
id: 4161042
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161042

UnificationXref1755
type: UnificationXref
id: Q9VMP4
db: UniProt

SequenceSite11250
type: SequenceSite
position status: EQUAL
sequence position: 584

UnificationXref1754
type: UnificationXref
id: 4161046
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161046

SequenceSite11251
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1751
type: UnificationXref
id: Q8MS48
db: UniProt

UnificationXref1750
type: UnificationXref
id: 4161038
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161038

phosphorylated residue
type: SequenceModificationVocabulary
xref: UnificationXref796

SequenceSite11249
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11248
type: SequenceSite
position status: EQUAL
sequence position: 766

SequenceSite11247
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11246
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11245
type: SequenceSite
position status: EQUAL
sequence position: 766

SequenceSite11243
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1769
type: UnificationXref
id: Q9VPV3
db: UniProt

SequenceSite11244
type: SequenceSite
position status: EQUAL
sequence position: 584

UnificationXref1768
type: UnificationXref
id: 4161074
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161074

SequenceSite11241
type: SequenceSite
position status: EQUAL
sequence position: 584

UnificationXref1767
type: UnificationXref
id: Q58CK5
db: UniProt

SequenceSite11242
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1766
type: UnificationXref
id: 4161070
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161070

UnificationXref1765
type: UnificationXref
id: Q0E8N6
db: UniProt

SequenceSite11240
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1764
type: UnificationXref
id: 4161066
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161066

UnificationXref1763
type: UnificationXref
id: Q5U168
db: UniProt

UnificationXref1762
type: UnificationXref
id: 4161062
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161062

UnificationXref1761
type: UnificationXref
id: Q8MSY7
db: UniProt

UnificationXref1760
type: UnificationXref
id: 4161058
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161058

SequenceSite11235
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11234
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11237
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11236
type: SequenceSite
position status: EQUAL
sequence position: 766

SequenceSite11239
type: SequenceSite
position status: EQUAL
sequence position: 766

SequenceSite11238
type: SequenceSite
position status: EQUAL
sequence position: 584

UnificationXref1775
type: UnificationXref
id: 4160915
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160915

UnificationXref1774
type: UnificationXref
id: 4160913
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160913

UnificationXref1777
type: UnificationXref
id: 4160919
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160919

UnificationXref1776
type: UnificationXref
id: 4160917
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160917

UnificationXref1779
type: UnificationXref
id: 4160923
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160923

SequenceSite11230
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1778
type: UnificationXref
id: 4160921
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160921

SequenceSite11231
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11232
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11233
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1771
type: UnificationXref
id: 4161079
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161079

UnificationXref1770
type: UnificationXref
id: 4161078
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161078

UnificationXref1773
type: UnificationXref
id: 4160911
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160911

UnificationXref1772
type: UnificationXref
id: 4161082
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161082

http://identifiers.org/pubmed/7917292
type: PublicationXref
id: 7917292
author: Furness, J
author: Doherty, P
author: Walsh, FS
author: Williams, EJ
db: Pubmed
title: Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin
source: Neuron 13:583-94
year: 1994

SequenceSite11226
type: SequenceSite
position status: EQUAL
sequence position: 626

SequenceSite11225
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11224
type: SequenceSite
position status: EQUAL
sequence position: 627

SequenceSite11223
type: SequenceSite
position status: EQUAL
sequence position: 626

SequenceSite11229
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11228
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11227
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1788
type: UnificationXref
id: 4160941
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160941

UnificationXref1787
type: UnificationXref
id: 4160939
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160939

UnificationXref1786
type: UnificationXref
id: 4160937
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160937

UnificationXref1785
type: UnificationXref
id: 4160935
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160935

SequenceSite11221
type: SequenceSite
position status: EQUAL
sequence position: 627

SequenceSite11222
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1789
type: UnificationXref
id: 4160943
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160943

SequenceSite11220
type: SequenceSite
position status: EQUAL
sequence position: 626

UnificationXref1780
type: UnificationXref
id: 4160925
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160925

UnificationXref1784
type: UnificationXref
id: 4160933
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160933

UnificationXref1783
type: UnificationXref
id: 4160931
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160931

UnificationXref1782
type: UnificationXref
id: 4160929
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160929

UnificationXref1781
type: UnificationXref
id: 4160927
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160927

UnificationXref1717
type: UnificationXref
id: Q9VMP3
db: UniProt

UnificationXref1716
type: UnificationXref
id: 4160970
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160970

UnificationXref1719
type: UnificationXref
id: B3DMP9
db: UniProt

UnificationXref1718
type: UnificationXref
id: 4160974
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160974

SequenceSite11291
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11290
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1712
type: UnificationXref
id: Q9TVI0
db: UniProt

SequenceSite11297
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1713
type: UnificationXref
id: MOD:01637
db: MOD

SequenceSite11296
type: SequenceSite
position status: EQUAL
sequence position: 177

UnificationXref1714
type: UnificationXref
id: MOD:00803
db: MOD

SequenceSite11299
type: SequenceSite
position status: EQUAL
sequence position: 177

UnificationXref1715
type: UnificationXref
id: MOD:01640
db: MOD

SequenceSite11298
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11293
type: SequenceSite
position status: EQUAL
sequence position: 177

SequenceSite11292
type: SequenceSite
position status: EQUAL
sequence position: 339

UnificationXref1710
type: UnificationXref
id: 4175680
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175680

SequenceSite11295
type: SequenceSite
position status: EQUAL
sequence position: 584

UnificationXref1711
type: UnificationXref
id: REACT_104348
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104348.9

SequenceSite11294
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1729
type: UnificationXref
id: Q8T0K9
db: UniProt

UnificationXref1728
type: UnificationXref
id: 4160994
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160994

SequenceSite11289
type: SequenceSite
position status: EQUAL
sequence position: 913

UnificationXref1727
type: UnificationXref
id: Q9V4A0
db: UniProt

Evidence999
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18347015
xref: http://identifiers.org/pubmed/21464368
xref: http://identifiers.org/pubmed/12486116
xref: http://identifiers.org/pubmed/11524432
xref: http://identifiers.org/pubmed/15692013
comment: In the endoplasmic reticulum, NOTCH receptor precursors are fucosylated on conserved serine and threonine residues in their EGF repeats. The consensus fucosylation site sequence is C2-X(4-5)-S/T-C3, where C2 and C3 are the second and third cysteine residue within the EGF repeat, and X(4-5) is four to five amino acid residues of any type. Only those fucosylation sites that are conserved between human, mouse and rat NOTCH isoforms are annotated. Two additional potential fucosylation sites exist in human NOTCH1, on threonine 194 and threonine 1321, but since they are not conserved between all three species, they are not shown. Fucosylation is performed by the endoplasmic reticulum resident O-fucosyl transferase (POFUT1). Fucosylation by POFUT1 is considered to be essential for NOTCH folding/processing and production of a fully functional receptor. In addition to Notch fucosylation, Drosophila Pofut1 (o-fut1) acts as a Notch chaperone, playing an important role in Notch trafficking (Okajima et al. 2005). The chaperone role of POFUT1 may not be conserved in mammals (Stahl et al. 2008).

Evidence998
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19648010
comment: The TGF-beta/BMP pathway incorporates several signaling pathways that share most, but not all, components of a central signal transduction engine. The general signaling scheme is rather simple: upon binding of a ligand, an activated plasma membrane receptor complex is formed, which passes on the signal towards the nucleus through a phosphorylated receptor SMAD (R-SMAD). In the nucleus, the activated R-SMAD promotes transcription in complex with a closely related helper molecule termed Co-SMAD (SMAD4). However, this simple linear pathway expands into a network when various regulatory components and mechanisms are taken into account. The signaling pathway includes a great variety of different TGF-beta/BMP superfamily ligands and receptors, several types of the R-SMADs, and functionally critical negative feedback loops. The R-SMAD:Co-SMAD complex can interact with a great number of transcriptional co-activators/co-repressors to regulate positively or negatively effector genes, so that the interpretation of a signal depends on the cell-type and cross talk with other signaling pathways such as Notch, MAPK and Wnt. The pathway plays a number of different biological roles in the control of embryonic and adult cell proliferation and differentiation, and it is implicated in a great number of human diseases. TGF beta (TGFB1) is secreted as a homodimer, and as such it binds to TGF beta receptor II (TGFBR2), inducing its dimerization. Binding of TGF beta enables TGFBR2 to form a stable hetero-tetrameric complex with TGF beta receptor I homodimer (TGFBR1). TGFBR2 acts as a serine/threonine kinase and phosphorylates serine and threonine residues within the short GS domain (glycine-serine rich domain) of TGFBR1. The phosphorylated heterotetrameric TGF beta receptor complex (TGFBR) internalizes into clathrin coated endocytic vesicles where it associates with the endosomal membrane protein SARA. SARA facilitates the recruitment of cytosolic SMAD2 and SMAD3, which act as R-SMADs for …

Evidence997
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11100470
xref: http://identifiers.org/pubmed/12482908
xref: http://identifiers.org/pubmed/9311995
xref: http://identifiers.org/pubmed/20207738
xref: http://identifiers.org/pubmed/18243111
xref: http://identifiers.org/pubmed/7693660
xref: http://identifiers.org/pubmed/9670020
xref: http://identifiers.org/pubmed/1333888
xref: http://identifiers.org/pubmed/9346966
xref: http://identifiers.org/pubmed/15350224
xref: http://identifiers.org/pubmed/11779505
xref: http://identifiers.org/pubmed/8242743
xref: http://identifiers.org/pubmed/8047140
xref: http://identifiers.org/pubmed/7737999
xref: http://identifiers.org/pubmed/15564041
xref: http://identifiers.org/pubmed/8947046
xref: http://identifiers.org/pubmed/9233797
xref: http://identifiers.org/pubmed/9865696
xref: http://identifiers.org/pubmed/21423151
xref: http://identifiers.org/pubmed/8980228
comment: Binding of transforming growth factor beta 1 (TGF beta 1, i.e. TGFB1) to TGF beta receptor type 2 (TGFBR2) activates TGF beta receptor signaling cascade. TGFB1 is posttranslationally processed by furin (Dubois et al. 1995) to form a homodimer and secreted to the extracellular space as part of the large latent complex (LLC). After the LLC disassembles in the extracellular space, dimeric TGFB1 becomes capable of binding to TGFBR2 (Annes et al. 2003, Keski Oja et al. 2004). Formation of TGFB1:TGFBR2 complex creates a binding pocket for TGF-beta receptor type-1 (TGFBR1) and TGFBR1 is recruited to the complex by binding to both TGFB1 and TGFBR2. This results in an active heterotetrameric TGF-beta receptor complex that consists of TGFB1 homodimer bound to two heterodimers of TGFBR1 and TGFBR2 (Wrana et al. 1992, Moustakas et al. 1993, Franzen et al. 1993). TGF-beta signaling can also occur through a single heterodimer of TGFBR1 and TGFBR2, although with decreased efficiency (Huang et al. 2011). TGFBR1 and TGFBR2 interact through their extracellular domains, which brings their cytoplasmic domains together. Ligand binding to extracellular receptor domains is cooperative, but no conformational change is seen from crystal structures of either TGFB1- or TGFB3-bound heterotetrameric receptor complexes (Groppe et al. 2008, Radaev et al. 2010). Activation of TGFBR1 by TGFBR2 in the absence of ligand is prevented by FKBP1A (FKBP12), a peptidyl-prolyl cis-trans isomerase. FKBP1A forms a complex with inactive TGFBR1 and dissociates from it only after TGFBR1 is recruited by TGFB1-bound TGFBR2 (Chen et al. 1997). Both TGFBR1 and TGFBR2 are receptor serine/threonine kinases. Formation of the hetero-tetrameric TGF-beta receptor complex (TGFBR) in response to TGFB1 binding induces receptor rotation, so that TGFBR2 and TGFBR1 cytoplasmic kinase domains face each other in a catalytically favourable configuration. TGFBR2 trans-phosphorylates serine residues at the conserved Gly-Ser-rich jux…

Evidence996
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14718519
xref: http://identifiers.org/pubmed/22344298
xref: http://identifiers.org/pubmed/9215638
xref: http://identifiers.org/pubmed/20061380
xref: http://identifiers.org/pubmed/20937913
xref: http://identifiers.org/pubmed/22045334
xref: http://identifiers.org/pubmed/15781469
xref: http://identifiers.org/pubmed/20129061
xref: http://identifiers.org/pubmed/12519765
xref: http://identifiers.org/pubmed/9335507
xref: http://identifiers.org/pubmed/10519551
xref: http://identifiers.org/pubmed/14701756
xref: http://identifiers.org/pubmed/11163210
xref: http://identifiers.org/pubmed/19758997
xref: http://identifiers.org/pubmed/12151385
xref: http://identifiers.org/pubmed/16061177
xref: http://identifiers.org/pubmed/10757800
xref: http://identifiers.org/pubmed/15496141
xref: http://identifiers.org/pubmed/16027725
xref: http://identifiers.org/pubmed/11158580
xref: http://identifiers.org/pubmed/11278251
comment: TGF-beta receptor signaling is downregulated by proteasome and lysosome-mediated degradation of ubiquitinated TGFBR1, SMAD2 and SMAD3, as well as by dephosphorylation of TGFBR1, SMAD2 and SMAD3. In the nucleus, SMAD2/3:SMAD4 complex stimulates transcription of SMAD7, an inhibitory SMAD (I-SMAD). SMAD7 binds phosphorylated TGFBR1 and competes with the binding of SMAD2 and SMAD3 (Hayashi et al. 1997, Nakao et al. 1997). Binding of SMAD7 to TGBR1 can be stabilized by STRAP, a protein that simultaneously binds SMAD7 and TGFBR1 (Datta et al. 2000). BAMBI simultaneously binds SMAD7 and activated TGFBR1, leading to downregulation of TGF-beta receptor complex signaling (Onichtchouk et al. 1999, Yan et al. 2009). In addition to competing with SMAD2/3 binding to TGFBR1, SMAD7 recruits protein phosphatase PP1 to phosphorylated TGFBR1, by binding to the PP1 regulatory subunit PPP1R15A (GADD34). PP1 dephosphorylates TGFBR1, preventing the activation of SMAD2/3 and propagation of TGF-beta signal (Shi et al. 2004). SMAD7 associates with several ubiquitin ligases, SMURF1 (Ebisawa et al. 2001, Suzuki et al. 2002, Tajima et al. 2003, Chong et al. 2010), SMURF2 (Kavsak et al. 2000, Ogunjimi et al. 2005), and NEDD4L (Kuratomi et al. 2005), and recruits them to phosphorylated TGFBR1 within TGFBR complex. SMURF1, SMURF2 and NEDD4L ubiquitinate TGFBR1 (and SMAD7), targeting TGFBR complex for proteasome and lysosome-dependent degradation (Ebisawa et al. 2001, Kavsak et al. 2000, Kuratomi et al. 2005). The ubiquitination of TGFBR1 can be reversed by deubiquitinating enzymes, UCHL5 (UCH37) and USP15, which may be recruited to ubiquitinated TGFBR1 by SMAD7 (Wicks et al. 2005, Eichhorn et al. 2012). Basal levels of SMAD2 and SMAD3 are maintained by SMURF2 and STUB1 ubiquitin ligases. SMURF2 is able to bind and ubiquitinate SMAD2, leading to SMAD2 degradation (Zhang et al. 2001), but this has been questioned by a recent study of Smurf2 knockout mice (Tang et al. 2011). STUB1 (CHIP) binds and ub…

Evidence995
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20061380
comment: MTMR4 protein phosphatase dephosphorylates SMAD2 and SMAD3, preventing formation of SMAD2/3:SMAD4 heterotrimers and inhibiting transmission of TGF-beta signal to the nucleus (Yu et al. 2010).

Evidence994
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20061380
comment: A protein phosphatase MTMR4, residing in the early endosome membrane, binds phosphorylated SMAD2 and SMAD3 (Yu et al. 2010).

Evidence993
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14701756
xref: http://identifiers.org/pubmed/15781469
comment: SMAD3, ubiquitinated by STUB1 (CHIP), is degraded in a proteasome-dependent manner. STUB1-mediated downregulation of SMAD3 level happens in the absence of TGF-beta stimulation. STUB1 may therefore keep the basal level of SMAD3 low in the absence of TGF-beta signaling (Li et al. 2004, Xin et al. 2005).

Evidence992
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14701756
xref: http://identifiers.org/pubmed/15781469
comment: STUB1 (CHIP) ubiquitinates SMAD3 in the absence of TGF-beta stimulation (Li et al. 2004, Xin et al. 2005).

SequenceSite11280
type: SequenceSite
position status: EQUAL
sequence position: 913

UnificationXref1725
type: UnificationXref
id: Q0KIF3
db: UniProt

SequenceSite11288
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1726
type: UnificationXref
id: 4160990
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160990

SequenceSite11287
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1723
type: UnificationXref
id: Q0KI42
db: UniProt

SequenceSite11286
type: SequenceSite
position status: EQUAL
sequence position: 913

UnificationXref1724
type: UnificationXref
id: 4160986
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160986

SequenceSite11285
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1721
type: UnificationXref
id: Q8IM95
db: UniProt

SequenceSite11284
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1722
type: UnificationXref
id: 4160982
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160982

SequenceSite11283
type: SequenceSite
position status: EQUAL
sequence position: 913

SequenceSite11282
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1720
type: UnificationXref
id: 4160978
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160978

SequenceSite11281
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1739
type: UnificationXref
id: Q8SYJ0
db: UniProt

SequenceSite11278
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1738
type: UnificationXref
id: 4161014
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161014

SequenceSite11279
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/12118249
type: PublicationXref
id: 12118249
author: Kato, RM
author: Guo, B
author: Leitges, M
author: Kawakami, T
author: Humphries, LA
author: Patrone, L
author: Wall, R
author: Sommer, K
author: Kang, S
author: Kawakami, Y
author: Teitell, M
author: Su, TT
author: Chae, K
author: Rawlings, DJ
db: Pubmed
title: PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling
source: Nat Immunol 3:780-6
year: 2002

UnificationXref1730
type: UnificationXref
id: 4160998
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160998

SequenceSite11271
type: SequenceSite
position status: EQUAL
sequence position: 626

UnificationXref1731
type: UnificationXref
id: Q9VDH2
db: UniProt

SequenceSite11270
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1732
type: UnificationXref
id: 4161002
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161002

SequenceSite11273
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1733
type: UnificationXref
id: B6IDJ4
db: UniProt

SequenceSite11272
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1734
type: UnificationXref
id: 4161006
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161006

SequenceSite11275
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1735
type: UnificationXref
id: Q0KIF2
db: UniProt

SequenceSite11274
type: SequenceSite
position status: EQUAL
sequence position: 913

UnificationXref1736
type: UnificationXref
id: 4161010
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161010

SequenceSite11277
type: SequenceSite
position status: EQUAL
sequence position: 913

UnificationXref1737
type: UnificationXref
id: Q24351
db: UniProt

SequenceSite11276
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11269
type: SequenceSite
position status: EQUAL
sequence position: 766

SequenceSite11267
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1749
type: UnificationXref
id: Q8IM94
db: UniProt

SequenceSite11268
type: SequenceSite
position status: EQUAL
sequence position: 626

http://identifiers.org/pubmed/2188967
type: PublicationXref
id: 2188967
author: Hackert, ML
author: Reed, LJ
db: Pubmed
title: Structure-function relationships in dihydrolipoamide acyltransferases.
source: J Biol Chem 265:8971-4
year: 1990

UnificationXref1740
type: UnificationXref
id: 4161018
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161018

UnificationXref1743
type: UnificationXref
id: Q9VDH5
db: UniProt

SequenceSite11262
type: SequenceSite
position status: EQUAL
sequence position: 132

UnificationXref1744
type: UnificationXref
id: 4161026
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161026

SequenceSite11261
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1741
type: UnificationXref
id: Q5U165
db: UniProt

SequenceSite11260
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1742
type: UnificationXref
id: 4161022
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161022

UnificationXref1747
type: UnificationXref
id: Q9V4E9
db: UniProt

SequenceSite11266
type: SequenceSite
position status: EQUAL
sequence position: 766

UnificationXref1748
type: UnificationXref
id: 4161034
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161034

SequenceSite11265
type: SequenceSite
position status: EQUAL
sequence position: 626

UnificationXref1745
type: UnificationXref
id: O45028
db: UniProt

SequenceSite11264
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1746
type: UnificationXref
id: 4161030
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4161030

SequenceSite11263
type: SequenceSite
position status: EQUAL
sequence position: 766

Evidence965
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19193720
comment: E3 ubiquitin ligase NEDD4 mediates ubiquitination of ERBB4 JM-A CYT-1 intracellular domain s80 (ERBB4jmAcyt1s80) produced by ERBB4 cleavage. This induces degradation of ERBB4jmAcyt1s80, and decreases the amount of ERBB4jmAcyt1s80 that reaches the nucleus.

Evidence966
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: WW-domain binding motifs in the C-tail of ERBB4 play an important role in the downregulation of ERBB4 receptor signaling, enabling the interaction of intact ERBB4, ERBB4 m80 and ERBB4 s80 with NEDD4 family of E3 ubiquitin ligases WWP1 and ITCH. The interaction of WWP1 and ITCH with intact ERBB4 is independent of receptor activation and autophosphorylation. Binding of WWP1 and ITCH ubiquitin ligases leads to ubiquitination of ERBB4 and its cleavage products, and subsequent degradation through both proteasomal and lysosomal routes (Omerovic et al. 2007, Feng et al. 2009). In addition, the s80 cleavage product of ERBB4 JM-A CYT-1 isoform is the target of NEDD4 ubiquitin ligase. NEDD4 binds ERBB4 JM-A CYT-1 s80 (ERBB4jmAcyt1s80) through its PIK3R1 interaction site and mediates ERBB4jmAcyt1s80 ubiquitination, thereby decreasing the amount of ERBB4jmAcyt1s80 that reaches the nucleus (Zeng et al. 2009).

Evidence963
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19047365
xref: http://identifiers.org/pubmed/17463226
comment: Upon binding to ERBB4 or its cleavage products m80 and s80, NEDD4 family ligases WWP1 and ITCH ubiquitinate intact and cleaved ERBB4 and target it for degradation.

Class B/2 (Secretin family receptors)
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction692
pathway component: BiochemicalReaction691
evidence: Evidence1070
xref: UnificationXref11166
xref: UnificationXref11167
pathway order: PathwayStep1066
pathway order: PathwayStep1067
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence964
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19193720
comment: E3 ubiquitin ligase NEDD4 binds intracellular domain of ERBB4 isoform JM-A CYT1 (ERBB4jmAcyt1s80) produced by ERBB4 cleavage.

Evidence961
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Besides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A CYT2) undergo proteolytic cleavage by ADAM17 (TACE) in the juxtamembrane region, resulting in shedding of the extracellular domain and formation of an 80 kDa membrane bound ERBB4 fragment known as ERBB4 m80 (Rio et al. 2000, Cheng et al. 2003). ERBB4 m80 undergoes further proteolytic cleavage, mediated by the gamma-secretase complex, which releases the soluble 80 kDa ERBB4 intracellular domain, known as ERBB4 s80 or E4ICD, into the cytosol (Ni et al. 2001). ERBB4 s80 is able to translocate to the nucleus, promote nuclear translocation of various transcription factors, and act as a transcription co-factor. In neuronal precursors, ERBB4 s80 binds the complex of TAB and NCOR1, helps to move the complex into the nucleus, and is a co-factor of TAB:NCOR1-mediated inhibition of expression of astrocyte differentiation genes GFAP and S100B (Sardi et al. 2006). In mammary cells, ERBB4 s80 recruits STAT5A transcription factor in the cytosol, shuttles it to the nucleus, and acts as the STAT5A co-factor in binding to and promoting transcription from the beta-casein (CSN2) promoter, and may be involved in the regulation of other lactation-related genes (Williams et al. 2004, Muraoka-Cook et al. 2008). ERBB4 s80 was also shown to bind activated estrogen receptor in the nucleus and act as its transcriptional co-factor in promoting transcription of some estrogen-regulated genes, such as progesterone receptor gene NR3C3 and CXCL12 i.e. SDF1 (Zhu et al. 2006). The C-tail of ERBB4 possesses several WW-domain binding motifs (three in CYT1 isoform and two in CYT2 isoform), which enable interaction of ERBB4 with WW-domain containing proteins. ERBB4 s80, through WW-domain binding motifs, interacts with YAP1 transcription factor, a known proto-oncogene, and may be a co-regulator of YAP1-mediated transcription (Komuro et al. 2003, Omerovic et al. 2004). The tumor …

Evidence962
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19047365
xref: http://identifiers.org/pubmed/17463226
comment: Intact ERBB4 isoforms and their membrane bound and cytosolic cleavage products, m80 and s80, bind NEDD4 family E3 ubiquitin ligases WWP1 and ITCH through WW-binding motifs in the C-tail. This interaction is independent of ligand binding and ERBB4 phosphorylation. CYT1 isoforms of ERBB4 have three WW-binding motifs: PY1, PY2 and PY3. PY2 motif is unique to CYT1 isoforms and overlaps with the PIK3R1 binding site. CYT2 isoform of ERBB4 has two WW-binding motifs: PY1 and PY3. While both CYT1 and CYT2 isoforms of ERBB4 all bind WWP1, CYT1 intracellular domain exhibits higher affinity for WWP1. Based on co-immunoprecipitation experiments in which individual WW-binding motifs of ERBB4 were mutated, Feng et al. established that PY2 had the highest affinity for WWP1, followed by PY3, while PY1 showed the lowest affinity.

Evidence960
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16778220
comment: Cytosolic ERBB4s80 is able to translocate to mitochondria where its BH3 domain, characteristic of BCL2 family members, may enable it to act as a pro-apoptotic factor.

Evidence969
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9605766
xref: http://identifiers.org/pubmed/2825022
xref: http://identifiers.org/pubmed/17222083
xref: http://identifiers.org/pubmed/11431473
xref: http://identifiers.org/pubmed/8288572
xref: http://identifiers.org/pubmed/12015138
xref: http://identifiers.org/pubmed/11804589
comment: The human genome includes approximately 70 genes that are predicted to encode Rho-specific GTPase Activating Proteins (RhoGAPs). As in the case of GEFs, some RhoGAPs are believed to be highly specific, whereas others are more promiscuous with respect to their target GTPases. Increasing evidence suggests that GAPs are also regulated by external cues in addition to being signal terminators leading to Rho GTPase inactivation. These proteins play important role in many Rho mediated signaling pathways. Some known GAPs include p190 A, cdGAP, ARAP3, MgcRacGAP, Chimaerin, Nadrin, TCGAP, DLC 1, 2, ArhGAP6, Myosin IXA. These and other GAPs have been implicated in many processes, such as exocytosis, endocytosis, cytokinesis, cell differentiation, migration, neuronal morphogenesis, angiogenesis and tumor suppression. Detailed annotations of the biological role of GAPs in Rho mediated signaling will be available in future releases.

Evidence967
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7565730
xref: http://identifiers.org/pubmed/17545517
xref: http://identifiers.org/pubmed/11679632
xref: http://identifiers.org/pubmed/9556621
xref: http://identifiers.org/pubmed/10867024
xref: http://identifiers.org/pubmed/9275162
xref: http://identifiers.org/pubmed/16912174
xref: http://identifiers.org/pubmed/8665853
xref: http://identifiers.org/pubmed/17018285
xref: http://identifiers.org/pubmed/15023535
xref: http://identifiers.org/pubmed/16978839
xref: http://identifiers.org/pubmed/18721752
xref: http://identifiers.org/pubmed/16778220
xref: http://identifiers.org/pubmed/19047365
xref: http://identifiers.org/pubmed/15534001
xref: http://identifiers.org/pubmed/16914727
xref: http://identifiers.org/pubmed/12807903
xref: http://identifiers.org/pubmed/10744726
xref: http://identifiers.org/pubmed/10722704
xref: http://identifiers.org/pubmed/8617750
xref: http://identifiers.org/pubmed/17463226
xref: http://identifiers.org/pubmed/16061658
xref: http://identifiers.org/pubmed/7929212
xref: http://identifiers.org/pubmed/12869563
xref: http://identifiers.org/pubmed/18653779
xref: http://identifiers.org/pubmed/19193720
xref: http://identifiers.org/pubmed/1706616
xref: http://identifiers.org/pubmed/9168115
xref: http://identifiers.org/pubmed/9135143
comment: ERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular ligand binding domain, a single transmembrane domain and a cytoplasmic domain which contains an active tyrosine kinase and a C-tail with multiple phosphorylation sites. At least three and possibly four splicing isoforms of ERBB4 exist that differ in their C-tail and/or the extracellular juxtamembrane regions: ERBB4 JM-A CYT1, ERBB4 JM-A CYT2 and ERBB4 JM-B CYT1 (the existence of ERBB4 JM-B CYT2 has not been confirmed). ERBB4 becomes activated by binding one of its seven ligands, three of which, HB-EGF, epiregulin EPR and betacellulin BTC, are EGF-like (Elenius et al. 1997, Riese et al. 1998), while four, NRG1, NRG2, NRG3 and NRG4, belong to the neuregulin family (Tzahar et al. 1994, Carraway et al. 1997, Zhang et al. 1997, Hayes et al. 2007). Upon ligand binding, ERBB4 forms homodimers (Sweeney et al. 2000) or it heterodimerizes with ERBB2 (Li et al. 2007). Dimers of ERBB4 undergo trans-autophosphorylation on tyrosine residues in the C-tail (Cohen et al. 1996, Kaushansky et al. 2008, Hazan et al. 1990, Li et al. 2007), triggering downstream signaling cascades. The pathway Signaling by ERBB4 only shows signaling by ERBB4 homodimers. Signaling by heterodimers of ERBB4 and ERBB2 is shown in the pathway Signaling by ERBB2. Ligand-stimulated ERBB4 is also able to form heterodimers with ligand-stimulated EGFR (Cohen et al. 1996) and ligand-stimulated ERBB3 (Riese et al. 1995). Dimers of ERBB4 with EGFR and dimers of ERBB4 with ERBB3 were demonstrated in mouse cell lines in which human ERBB4 and EGFR or ERBB3 were exogenously expressed. These heterodimers undergo trans-autophosphorylation, but their downstream signaling and physiological significance have not been studied. All splicing isoforms of ERBB4 possess two tyrosine residues in the C-tail that serve as docking sites for SH…

Evidence968
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12101119
xref: http://identifiers.org/pubmed/10559246
xref: http://identifiers.org/pubmed/8810315
xref: http://identifiers.org/pubmed/8969170
xref: http://identifiers.org/pubmed/7478592
xref: http://identifiers.org/pubmed/9308960
xref: http://identifiers.org/pubmed/8276860
xref: http://identifiers.org/pubmed/16212495
xref: http://identifiers.org/pubmed/9857026
xref: http://identifiers.org/pubmed/7954831
xref: PublicationXref1239
comment: Guanine nucleotide exchange factors (GEFs) activate GTPases by enhancing the exchange of bound GDP for GTP. Much evidence points to GEFs being critical mediators of Rho GTPase activation (Schmidt and Hall, 2002). Many GEFs are known to be highly specific for a particular GTPase, e.g. Fgd1/Cdc42 and p115RhoGEF/Rho (Hart et al., 1996, Zheng et al., 1996). Others have a broader spectrum and activate several GTPases, e.g. Vav1 for Rac, Rho, and Cdc42 (Hart et al, 1994).

Evidence952
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11679632
comment: The soluble intracellular domain of ERBB4 s80 (E4ICD) is able to translocate from the cytosol to the nucleus.

Evidence953
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17018285
comment: ERBB4s80 (E4ICD) binds cytosolic TAB2:NCOR1 complex through direct interaction with TAB2.

SequenceSite800
type: SequenceSite
position status: EQUAL
sequence position: 902

Evidence954
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17018285
comment: ERBB4s80 (E4ICD) bound to cytosolic TAB2:NCOR1 complex mediates the translocation of this complex to the nucleus.

SequenceSite801
type: SequenceSite
position status: EQUAL
sequence position: 21

Evidence955
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16061658
xref: http://identifiers.org/pubmed/19047365
comment: WWOX binds to ERBB4s80 through WW-domain binding motifs in the C-tail of ERBB4. Formation of ERBB4s80:WWOX complex competes with the formation of ERBB4:YAP1 complex and prevents translocation of ERBB4s80 to the nucleus. Feng et al. established that WWOX binds with the same affinity to s80CYT1 and s80CYT2, and identified PY3 as the most important WW-domain binding motif for WWOX binding.

SequenceSite802
type: SequenceSite
position status: EQUAL
sequence position: 902

Evidence950
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: The CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen et al. 1996). Binding of PIK3R1 to CYT1 isoforms of ERBB4 is followed by recruitment of the p110 catalytic subunit of PI3K (PIK3CA), leading to assembly of an active PI3K complex that converts PIP2 to PIP3 and activates AKT signaling (Kainulainen et al. 2000).

Evidence951
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11679632
comment: After ERBB4 is cleaved by ADAM17, gamma-secretase complex performs additional cleavage in the transmembrane region of the m80 ERBB4 fragment, releasing the soluble ERBB4 intracellular domain of 80 kDa, known as s80 or E4ICD.

SequenceSite807
type: SequenceSite
position status: EQUAL
sequence position: 21

SequenceSite808
type: SequenceSite
position status: EQUAL
sequence position: 902

SequenceSite809
type: SequenceSite
position status: EQUAL
sequence position: 25

Evidence956
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15023535
xref: http://identifiers.org/pubmed/19047365
xref: http://identifiers.org/pubmed/12807903
comment: ERBB4s80 interacts with a co-transcriptional activator YAP1 through its WW-domain binding motifs in the C-tail. Feng et al. established that the PY2 motif, present in CYT1 isoforms of ERBB4 only, has the highest affinity for YAP1 binding. PY1 and PY3 motifs, shared between CYT1 and CYT2 isoforms, have lower binding affinity for YAP1, with PY1 motif being the least important for YAP1 interaction.

SequenceSite803
type: SequenceSite
position status: EQUAL
sequence position: 21

Evidence957
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16061658
xref: http://identifiers.org/pubmed/15023535
xref: http://identifiers.org/pubmed/12807903
comment: Upon formation of ERBB4s80:YAP1 complex in the cytosol, the complex translocates to the nucleus, where it may act as a regulator of transcription.

SequenceSite804
type: SequenceSite
position status: EQUAL
sequence position: 902

Evidence958
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18653779
xref: http://identifiers.org/pubmed/15534001
comment: ERBB4s80 binds STAT5A through STAT5A SH2 domain. This interaction likely depends on STAT5A activation induced by prolactin and mediated by JAK2. Heterodimers of prolactin receptor (PRLR) and JAK2 are activated by prolactin binding, resulting in STAT5 recruitment and phosphorylation, and subsequent formation of phosphorylated STAT5 homodimers. There is evidence that ERBB4 may be part of the PRLR:JAK2 complex and that it may be activated by JAK2-mediated phosphorylation, in the absence of ERBB4 growth factors (Muraoka-Cook et al. 2008).

SequenceSite805
type: SequenceSite
position status: EQUAL
sequence position: 21

Evidence959
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18653779
xref: http://identifiers.org/pubmed/15534001
comment: Formation of cytosolic complex of ERBB4s80 and STAT5A promotes translocation of STAT5A to the nucleus, with ERBB4s80 acting as a nuclear chaperone of STAT5A.

SequenceSite806
type: SequenceSite
position status: EQUAL
sequence position: 902

Evidence991
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14701756
xref: http://identifiers.org/pubmed/15781469
comment: STUB1 (CHIP), an E3 ubiquitin ligase, binds SMAD3 irrespective of TGF-beta stimulation (Li et al. 2004, Xin et al. 2005).

Evidence990
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/22045334
xref: http://identifiers.org/pubmed/11158580
comment: Ubiquitinated SMAD2 undergoes proteasome-dependent degradation. Therefore, SMURF2 decreases the level of SMAD2 in the cell, irrespective of TGF-beta signaling, and may regulate the competence of a cell to respond to TGF-beta signaling (Zhang et al. 2001). These findings are contradicted by a recent study of Smurf2 knockout mice, where Smad2 protein levels were found to be unaltered in the absence of Smurf2 (Tang et al. 2011).

Evidence983
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12519765
xref: http://identifiers.org/pubmed/20937913
xref: http://identifiers.org/pubmed/11278251
comment: SMAD7 binds to SMURF1 in the nucleus (Ebisawa et al. 2001, Tajima et al. 2003). SMURF1 domains WW1 and WW2, highly similar to WW2 and WW3 domains of SMURF2, are involved in SMAD7 binding. SMURF1 has two splicing isoforms. The shorter splicing isoform of SMURF1 has an inter-WW domain linker of the same length as the WW2-WW3 domain linker of SMURF2. The longer isoform of SMURF1 has a longer WW1-WW2 domain linker, resulting in decreased affinity of the longer SMURF1 isoform for SMAD7 (Chong et al. 2010). This is based on experiments with recombinant mouse Smad7 and recombinant human SMURF1.

Evidence984
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12519765
comment: SMAD7:SMURF1 complex binds to XPO1 (CRM1) through a nuclear export signal (NES) located in the C-terminus of SMURF1 (Tajima et al. 2003). Recombinant mouse Smad7 and recombinant human SMURF1 were used in this study.

Evidence981
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11163210
xref: http://identifiers.org/pubmed/16061177
comment: SMURF2, an E3 ubiquitin protein ligase, binds to SMAD7 in the nucleus. WW2 and WW3 domains of SMURF2 are both required for binding PY motif (PPXY sequence) of SMAD7. Endogenous human SMAD7 and SMURF2 were shown to form a complex in human U4A/Jak1 cells, derived from a sarcoma cell line 2fTGH. The interaction was studied in more detail by expressing tagged recombinant human SMURF2 and mouse Smad7 in human embryonic kidney cell line HEK293 (Kavsak et al. 2000, Ogunjimi et al. 2005).

Evidence982
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11163210
comment: After forming a complex in the nucleus, SMAD7:SMURF2 traffics to the cytosol (Kavsak et al. 2000). This was inferred from experiments that used a recombinant mouse Smad7 and recombinant human SMURF2.

Evidence987
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15496141
comment: Binding of NEDD4L promotes translocation of SMAD7 to the cytosol (Kuratomi et al. 2005). This is based on experiments using recombinant mouse Smad7 and recombinant human NEDD4L.

SequenceSite812
type: SequenceSite
position status: EQUAL
sequence position: 883

Evidence988
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11158580
comment: SMURF2 binds SMAD2 irrespective of TGF-beta signaling (Zhang et al. 2001).

SequenceSite813
type: SequenceSite
position status: EQUAL
sequence position: 25

Evidence985
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12519765
xref: http://identifiers.org/pubmed/12151385
comment: After SMAD7:SMURF1 complex binds to XPO1 (CRM1) through the nuclear export signal (NES) in the C-terminus of SMURF1, XPO1 enables transport of SMAD7:SMURF1 to the cytosol (Suzuki et al. 2002, Tajima et al. 2003). A recombinant mouse Smad7 and recombinant human SMURF1 were used in these experiments.

SequenceSite810
type: SequenceSite
position status: EQUAL
sequence position: 883

Evidence986
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15496141
comment: NEDD4L ubiquitin ligase, structurally similar to SMURF ubiquitin ligases, binds SMAD7 (Kuratomi et al. 2005). This was inferred from experiments that used recombinant mouse Smad7 and recombinant human NEDD4L.

SequenceSite811
type: SequenceSite
position status: EQUAL
sequence position: 25

SequenceSite816
type: SequenceSite
position status: EQUAL
sequence position: 883

SequenceSite817
type: SequenceSite
position status: EQUAL
sequence position: 25

Evidence989
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11158580
comment: SMAD2 is polyubiquitinated by SMURF2 and targeted for proteasome-mediated degradation.

SequenceSite814
type: SequenceSite
position status: EQUAL
sequence position: 883

SequenceSite815
type: SequenceSite
position status: EQUAL
sequence position: 25

SequenceSite818
type: SequenceSite
position status: EQUAL
sequence position: 883

SequenceSite819
type: SequenceSite
position status: EQUAL
sequence position: 19

http://identifiers.org/pubmed/19513348
type: PublicationXref
id: 19513348
author: Szczepanowska, J
db: Pubmed
title: Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements
source: Acta Biochim Pol 56:225-34
year: 2009

Evidence980
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15621726
comment: The TGF-beta/BMP (bone morphogenetic protein) pathway incorporates several signalling pathways that share most, but not all, components of a central signal transduction engine. The general signalling scheme is rather simple: upon binding of a ligand, an activated plasma membrane receptor complex is formed, which passes on the signal towards the nucleus through a phosphorylated receptor-activated SMAD (r-SMAD). In the nucleus, the activated r-SMAD promotes transcription in a complex with a closely-related helper molecule termed the Co-SMAD. However, this simple linear pathway expands into a network when various regulatory components and mechanisms are taken into account. The signalling pathway includes a great variety of different TGF-beta/BMP superfamily ligands and receptors, several types of the r-SMAD, and functionally critical negative feedback loops. The r-SMAD/Co-SMAD can interact with a great number of transcriptional co-activators/co-repressors to regulate positively or negatively effector genes, so that the interpretation of a signal depends on the cell-type and cross talk with other signalling pathways such as Notch, MAPK and Wnt. The pathway plays a number of different biological roles in the control of embryonic and adult cell proliferation and differentiation, and it is implicated in a great number of human diseases.

Evidence970
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10676816
xref: http://identifiers.org/pubmed/15292224
xref: http://identifiers.org/pubmed/1439791
xref: http://identifiers.org/pubmed/16190977
xref: http://identifiers.org/pubmed/15921909
xref: http://identifiers.org/pubmed/10655614
xref: http://identifiers.org/pubmed/10433515
xref: http://identifiers.org/pubmed/9194563
xref: http://identifiers.org/pubmed/9113980
xref: http://identifiers.org/pubmed/7824266
xref: http://identifiers.org/pubmed/7543319
comment: GDP dissociation inhibitors or GDIs confer an additional but important layer of Rho GTPase regulation along with GEFs and GAPs. GDIs mainly inhibit the dissociation of bound guanine nucleotide (usually GDP) from their partner GTPases. So far, three human GDIs with proven biological functions have been found: RhoGDI/GDIalpha/GDI1, hematopoietic cell selective Ly/D4GDI/GDIbeta/GDI2, and Rho GDIgamma/GDI3 (DerMardirossian and Bokoch, 2005). Three specific biochemical functions of GDIs have been established: inhibiting the dissociation of GDP from Rho proteins, maintaining the GTPases in an inactive form, and preventing GTPase activation by GEFs (Olofsson, 1999). Detailed annotations of GDIs will be available in future releases.

Evidence971
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10676816
xref: http://identifiers.org/pubmed/15921909
xref: http://identifiers.org/pubmed/10655614
xref: http://identifiers.org/pubmed/9194563
xref: http://identifiers.org/pubmed/12471028
comment: GDIs sequester the inactive GTPases, preventing the dissociation of GDP and interactions with regulatory and effector molecules. They maintain Rho GTPases as soluble cytosolic proteins by forming high affinity complexes. In these complexes, the geranylgeranyl membrane targeting moiety present at the C terminus of the Rho GTPases is shielded from the solvent by its insertion into the hydrophobic pocket formed by the immunoglobulin like beta sandwich of the GDI (DerMardirossian and Bokoch, 2005). Rho proteins, when released from the sequestering cytosolic GDIs, insert into the lipid bilayer of the plasma membrane with their isoprenylated C termini. The membrane bound GEFs activate these free RhoGTPases and thereby trigger the downstream signaling events via respective effector proteins on the membrane (Robbe et al., 2003). Detailed annotation of the activities of farnesyltransferase / geranylgeranyltransferases on prenylation of Rho GTPases thereby enabling their subsequent localization to plasma membrane will be available in future releases.

Evidence972
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17222083
xref: http://identifiers.org/pubmed/9308960
xref: http://identifiers.org/pubmed/16212495
comment: The cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the cytoplasm, (2) guanine nucleotide exchange factors or GEFs, which destabilize the interaction between Rho proteins and their bound nucleotide, the net result of which is the exchange of bound GDP for the more abundant GTP, and (3) GTPase Activating Proteins or GAPs, which stimulate the low intrinsic GTP hydrolysis activity of Rho family members, thus promoting their inactivation. GDIs, GEFs, and GAPs are themselves subject to tight regulation, and the overall level of Rho activity reflects the balance of their activities. In their active GTP-bound state, Rho family members have the ability to interact with a large variety of so-called effector proteins. By changing the subcellular localization of effectors, by altering their enzymatic properties, or by directing the formation of specific effector complexes, members of the Rho family mediate their various effects. This Rho GTPase cycle is diagrammed in the figure below. External or internal cues promote the release of Rho GTPases from the inhibitory complex (1) which allows them to associate with the plasma membrane (2) where they are activated by GEFs (3) and can signal to effector proteins. Then, GAPs inactivate the GTPases by accelerating the intrinsic GTPase activity, leading to the GDP bound form (4). Once again, the GDI molecules stabilize the inactive GDP bound form in the cytoplasm, waiting for further instructions (5). (Figure and text from Tcherkezian and Lamarche Vane, 2007).

Evidence973
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10445846
xref: http://identifiers.org/pubmed/12101119
xref: http://identifiers.org/pubmed/12618308
xref: http://identifiers.org/pubmed/16212495
xref: http://identifiers.org/pubmed/16757309
xref: http://identifiers.org/pubmed/14521508
xref: http://identifiers.org/pubmed/15630019
comment: The Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as binary switches controlling a variety of biological processes. They perform this function by cycling between active GTP-bound and inactive GDP-bound conformations. Mammalian Rho GTPases include RhoA, RhoB and RhoC (Rho proteins), Rac1 3 (Rac proteins), Cdc42, TC10, TCL, Wrch1, Chp/Wrch2, RhoD and RhoG, to name some. The family also includes RhoH and Rnd1-3, which lack GTPase activity and are predicted to exist in a constitutively active state. Members of the Rho family have been identified in all eukaryotes. Including the atypical RHOBTB1-3 and RHOT1-2 proteins, 24 Rho family members have been identified in mammals (Jaffe and Hall, 2005; Bernards, 2005; Ridley, 2006). Among Rho GTPases, RhoA, Rac1 and Cdc42 have been most extensively studied. These proteins are best known for their ability to induce dynamic rearrangements of the plasma membrane-associated actin cytoskeleton (Aspenstrom et al, 2004; Murphy et al, 1999; Govek et al, 2005). Beyond this function, Rho GTPases also regulate actomyosin contractility and microtubule dynamics. Rho mediated effects on transcription and membrane trafficking are believed to be secondary to these functions. At the more macroscopic level, Rho GTPases have been implicated in many important cell biological processes, including cell growth control, cytokinesis, cell motility, cell cell and cell extracellular matrix adhesion, cell transformation and invasion, and development (Govek et al., 2005). The illustration below lists Rho GTPase effectors implicated in actin and microtubule dynamics (courtesy: Govek et al., 2005, Genes and Development, CSHL Press). Detailed annotations of various biological processes regulated by Rho GTPases will be available in future releases.

SequenceSite820
type: SequenceSite
position status: EQUAL
sequence position: 906

Evidence974
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16672363
xref: http://identifiers.org/pubmed/10712517
xref: http://identifiers.org/pubmed/11714695
comment: BMP receptors, unlike TGF-beta receptors are known to form hetero-oligomeric complexes in the endoplasmic reticulum and are transported as oligomers to the plasma membrane where they bind ligand. However, evidence for ligand-induced heteromeric BMP receptor complexes on the cell surface has also been published, leading to a model where both pre-formed and ligand-induced receptor oligomers are encountered on the plasma membrane. Based on the latter, a theory has been formulated that suggests that the signaling outcome from pre-formed and ligand-induced BMP receptor complexes is different. The mechanism that might explain this theory must involve different ways of internalization and trafficking of the BMP receptor complexes.

SequenceSite821
type: SequenceSite
position status: EQUAL
sequence position: 19

Evidence975
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: The mature dimeric BMP2 binds with high affinity to its signalling receptor, the type II receptor serine/threonine kinase. The type II receptor is known to form dimeric complexes even in the absence of BMP2.

SequenceSite822
type: SequenceSite
position status: EQUAL
sequence position: 906

Evidence976
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7791754
xref: http://identifiers.org/pubmed/7644468
comment: Formation of the hetero-tetrameric BMP2:receptor complex induces receptor rotation, so that their cytoplasmic kinase domains face each other in a catalytically favourable configuration. The constitutively active type II receptor kinase (which auto-phosphorylates in the absence of ligand), trans-phosphorylates specific serine residues at the conserved Gly-Ser-rich juxtapositioned domain of the type I receptor. It is not known if exactly 8 ATPs are required for the phosphorylation of type I receptor, there could be more or less than this number.

SequenceSite823
type: SequenceSite
position status: EQUAL
sequence position: 19

Evidence977
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12151385
xref: http://identifiers.org/pubmed/12857866
xref: http://identifiers.org/pubmed/11278251
comment: Smad6 and Smad7, the two I-Smads, bind directly to the BMP type I receptors and recruit the ubiquitin ligase Smurf1. This reaction leads to competitive inhibition of R-Smad binding to the type I receptor and activating phosphorylation by the receptor, and also leads to BMP receptor ubiquitination and degradation.

SequenceSite824
type: SequenceSite
position status: EQUAL
sequence position: 906

Evidence978
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11100470
xref: http://identifiers.org/pubmed/8653785
xref: http://identifiers.org/pubmed/9136927
comment: Activated type I receptor kinase directly phosphorylates two of the C-terminal serine residues of SMAD2 or SMAD3. Binding of these R-SMADs to the L45 loop of the type I receptor is critical for this event.

SequenceSite825
type: SequenceSite
position status: EQUAL
sequence position: 19

Evidence979
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12519765
xref: http://identifiers.org/pubmed/12857866
comment: I-SMADs reside in the nucleus presumably to be sequestered from the BMP2:receptor complex and thus avoid inappropriate silencing of the signalling pathway. Upon activation of the signalling pathway, I-SMADs exit the nucleus and are recruited to the signalling BMP2:receptor complex. I-SMADs directly bind to the so-called L45 loop of the type I receptor, the site of binding of R-SMADs. Thus, I-SMADs competitively inhibit the activation/phosphorylation of R-SMADs.

SequenceSite826
type: SequenceSite
position status: EQUAL
sequence position: 906

SequenceSite827
type: SequenceSite
position status: EQUAL
sequence position: 19

SequenceSite828
type: SequenceSite
position status: EQUAL
sequence position: 906

SequenceSite829
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref1794
type: UnificationXref
id: 4160953
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160953

UnificationXref1795
type: UnificationXref
id: 4160955
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160955

UnificationXref1792
type: UnificationXref
id: 4160949
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160949

UnificationXref1793
type: UnificationXref
id: 4160951
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160951

UnificationXref1790
type: UnificationXref
id: 4160945
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160945

UnificationXref1791
type: UnificationXref
id: 4160947
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160947

UnificationXref1798
type: UnificationXref
id: 4160961
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160961

UnificationXref1799
type: UnificationXref
id: 4160963
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160963

UnificationXref1796
type: UnificationXref
id: 4160957
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160957

UnificationXref1797
type: UnificationXref
id: 4160959
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4160959

Evidence929
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10508235
xref: http://identifiers.org/pubmed/15207811
xref: http://identifiers.org/pubmed/9739761
comment: Platelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary endothelial cells and neurons.The PDGF family of growth factors is composed of four different polypeptide chains encoded by four different genes. The classical PDGF chains, PDGF-A and PDGF-B, and more recently discovered PDGF-C and PDGF-D. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD. It is notable that no heterodimers involving PDGF-C and PDGF-D chains have been described. PDGF exerts its effects by binding to, and activating, two protein tyrosine kinase (PTK) receptors, alpha and beta. These receptors dimerize and undergo autophosphorylation. The phosphorylation sites then attract downstream effectors to transduct the signal into the cell.

Evidence928
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10508235
xref: http://identifiers.org/pubmed/1374684
xref: http://identifiers.org/pubmed/9739761
comment: The role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of around 100 amino acids that can bind a phosphorylated tyrosine residue. These downstream molecules are activated upon binding to, or phosphorylated by, the receptor kinases intrinsic to PDGF receptors. Some of the dowstream molecules are themselves enzymes, such as phosphatidylinositol 3'-kinase (PI3K), phospholipase C (PLC-gamma), the Src family of tyrosine kinases, the tyrosine phosphatase SHP2, and a GTPase activating protein (GAP) for Ras. Others such as Grb2 are adaptor molecules which link the receptor with downstream catalytic molecules.

Evidence927
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Neurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in minute amounts, by a variety of tissues. They signal through two types of receptors: TRK tyrosine kinase receptors (TRKA, TRKB, TRKC), which specifically interact with the different neurotrophins, and p75NTR, which interacts with all neurotrophins. TRK receptors are reported in a variety of tissues in addition to neurons. p75NTRs are also widespread. Neurotrophins and their receptors are synthesized as several different splice variants, which differ in terms of their biological activities. The nerve growth factor (NGF) was the first growth factor to be identified and has served as a model for studying the mechanisms of action of neurotrophins and growth factors. The mechanisms by which NGF generates diverse cellular responses have been studied extensively in the rat pheochromocytoma cell line PC12. When exposed to NGF, PC12 cells exit the cell cycle and differentiate into sympathetic neuron-like cells. Current data show that signalling by the other neurotrophins is similar to NGF signalling.

Evidence926
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11520933
xref: http://identifiers.org/pubmed/10579918
xref: PublicationXref1180
xref: http://identifiers.org/pubmed/10851172
comment: Trk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes is slower but long lasting. Signalling from the plasma membrane is annotated here. TRK signalling leads to proliferation in some cell types and neuronal differentiation in others. Proliferation is the likely outcome of short term signalling, as observed following stimulation of EGFR (EGF receptor). Long term signalling via TRK receptors, instead, was clearly shown to be required for neuronal differentiation in response to neurotrophins.

Evidence925
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8833451
comment: An important function of the kinase cascade triggered by neurotrophins is to induce the phosphorylation and activation of transcription factors in the nucleus to initiate new programs of gene expression. Transcription factors directly activated by neurotrophin signalling are responsible for induction of immediate-early genes, many of which are transcription factors. These in turn are involved in the induction of delayed-early genes.

Evidence924
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Nerve growth factor (NGF) activates multiple signalling pathways that mediate the phosphorylation of CREB at the critical regulatory site, serine 133. CREB phosphorylation at serine 133 is a crucial event in neurotrophin signalling, being mediated by ERK/RSK, ERK/MSK1 and p38/MAPKAPK2 pathways. Several kinases, such as MSK1, RSK1/2/3 (MAPKAPK1A/B/C), and MAPKAPK2, are able to directly phosphorylate CREB at S133. MSK1 is also able to activate ATF (Cyclic-AMP-dependent transcription factor). However, the NGF-induced CREB phosphorylation appears to correlate better with activation of MSK1 rather than RSK1/2/3, or MAPKAPK2. In retrograde signalling, activation of CREB occurs within 20 minutes after neurotrophin stimulation of distal axons.

Evidence923
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: p38 MAPK activation leads to CREB Serine 133 phosphorylation through the activation of MAPKAP kinase 2 or the closely related MAPKAP kinase 3.

Evidence922
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9770464
comment: CREB is phosphorylated at Serine 133 by RSK1/2/3.

Evidence921
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Cyclic-AMP-dependent transcription factor 1 (ATF1) can be phosphorylated at Serine 63 by MSK1, thus activating it.

Evidence920
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9687510
comment: MSK1 is required for the mitogen-induced phosphorylation of the transcription factor, cAMP response element-binding protein (CREB).

Evidence917
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17322878
comment: Over 10 dual specificity phosphatases (DUSPs) active an MAP kinases are known. Among them, some possess good ERK docking sites and so are more specific for the ERKS (DUSP 3, 4, 6, 7), others are more specific for p38MAPK (DUSP1 and 10), while others do not seem to discriminate. It is noteworthy that transcription of DUSP genes is induced by growth factor signaling itself, so that these phosphatases provide feedback attenuation of signaling. Moreover, differential activation of DUSPs by different stimuli is thought to contribute to pathway specificity.

Evidence916
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16456541
comment: ERKs are inactivated by the protein phosphatase 2A (PP2A). The PP2A holoenzyme is a heterotrimer that consists of a core dimer, composed of a scaffold (A) and a catalytic (C) subunit that associates with a variety of regulatory (B) subunits. The B subunits have been divided into gene families named B (or PR55), B0 (or B56 or PR61) and B00 (or PR72). Each family comprises several members. B56 family members of PP2A in particular, increase ERK dephosphorylation, without affecting its activation by MEK. Induction of PP2A is involved in the extracellular signal-regulated kinase (ERK) signalling pathway, in which it provides a feedback control, as well as in a broad range of other cellular processes, including transcriptional regulation and control of the cell cycle.This diversity of functions is conferred by a diversity of regulatory subunits, the combination of which can give rise to over 50 different forms of PP2A. For example, five distinct mammalian genes encode members of the B56 family, called B56a, b, g, d and e, generating at least eight isoforms. Whether a specific holoenzyme dephosphorylates ERK and whether this activity is controlled during mitogenic stimulation is unknown.

Evidence919
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: ERK/MAPK kinases have a number of targets within the nucleus, usually transcription factors or other kinases. The best known targets, ELK1, ETS1, ATF2, MITF, MAPKAPK2, MSK1, RSK1/2/3 and MEF2 are annotated here.

Evidence918
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15115656
xref: http://identifiers.org/pubmed/17322878
comment: MAP Kinases are inactivated by a family of protein named MAP Kinase Phosphatases (MKPs). They act through dephosphorylation of threonine and/or tyrosine residues within the signature sequence -pTXpY- located in the activation loop of MAP kinases (pT=phosphothreonine and pY=phosphotyrosine). MKPs are divided into three major categories depending on their preference for dephosphorylating; tyrosine, serine/threonine and both the tyrosine and threonine (dual specificity phoshatases or DUSPs). The tyrosine-specific MKPs include PTP-SL, STEP and HePTP, serine/threonine-specific MKPs are PP2A and PP2C, and many DUSPs acting on MAPKs are known. Activated MAP kinases trigger activation of transcription of MKP genes. Therefore, MKPs provide a negative feedback regulatory mechanism on MAPK signaling, by inactivating MAPKs via dephosphorylation, in the cytoplasm and the nucleus. Some MKPs are more specific for ERKs, others for JNK or p38MAPK.

Evidence913
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9687510
comment: MSK1 (Ribosomal protein S6 kinase alpha-5) is a serine/threonine kinase that is localised in the nucleus. It contains two protein kinase domains in a single polypeptide. It can be activated 5-fold by ERK1/2 through phosphorylation at four key residues.

Evidence912
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Neurotrophin-TRK complexes can be internalized and enter signalling vesicles, which travel retrogradely over long distances from distal nerve terminals to neuronal cell bodies. Such retrograde signalling by neurotrophin-TRK complexes regulates survival, synaptogenesis and maintenance of proper neural connectivity. The neurotrophin-TRK complex may use three distinct internalization pathways. Although Clathrin-mediated endocytosys appears to be the major internalization route, it is controversial whether it also represents the dominant pathway for retrograde transport and signalling. Pyncher-mediated endocytosis might be more relevant in this regard. Moreover, also caveolin-mediated endocytosis may play a role in NGF-TrkA internalization. Retrograde transport of TRKs is microtubule-dependent: TRKs remain activated and bound to neurotrophins during retrograde transport. The current view is reflected in the signalling endosome model. It is a specialized vesicle containing ligand (NGF, BDNF) bound to its activated TRK receptor, together with activated downstream signalling proteins, transported by motor proteins (dyneins) from nerve terminals to remote cell bodies, where the receptors trigger signalling cascades.

Evidence915
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16626623
comment: The p90 ribosomal S6 kinases (RSK1-4) comprise a family of serine/threonine kinases that lie at the terminus of the ERK pathway. RSK family members are unusual among serine/threonine kinases in that they contain two distinct kinase domains, both of which are catalytically functional . The C-terminal kinase domain is believed to be involved in autophosphorylation, a critical step in RSK activation, whereas the N-terminal kinase domain, which is homologous to members of the AGC superfamily of kinases, is responsible for the phosphorylation of all known exogenous substrates of RSK. RSKs can be activated by the ERKs (ERK1, 2, 5) in the cytoplasm as well as in the nucleus, they both have cytoplasmic and nuclear substrates, and they are able to move from nucleus to cytoplasm. Efficient RSK activation by ERKs requires its interaction through a docking site located near the RSK C terminus. The mechanism of RSK activation has been studied mainly with regard to ERK1 and ERK2. RSK activation leads to the phosphorylation of four essential residues Ser239, Ser381, Ser398, and Thr590, and two additional sites, Thr377 and Ser749 (the amino acid numbering refers to RSK1). ERK is thought to play at least two roles in RSK1 activation. First, activated ERK phosphorylates RSK1 on Thr590, and possibly on Thr377 and Ser381, and second, ERK brings RSK1 into close proximity to membrane-associated kinases that may phosphorylate RSK1 on Ser381 and Ser398. Moreover, RSKs and ERK1/2 form a complex that transiently dissociates upon growth factor signalling. Complex dissociation requires phosphorylation of RSK1 serine 749, a growth factor regulated phosphorylation site located near the ERK docking site. Serine 749 is phosphorylated by the N-terminal kinase domain of RSK1 itself. ERK1/2 docking to RSK2 and RSK3 is also regulated in a similar way. The length of RSK activation following growth factor stimulation depends on the duration of the RSK/ERK complex, which, in turn, differs among the diffe…

Evidence914
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9687510
comment: MSK1 (Ribosomal protein S6 kinase alpha-5) is a serine/threonine kinase that is localised in the nucleus. It contains two protein kinase domains in a single polypeptide. It can be activated 5-fold by p38MAPK through phosphorylation at four key residues.

Evidence911
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11157096
comment: Of the internalized NGF:TRK complexes, many undergo recycling and/or proteolysis. Only a small fraction is retrogradely transported. Vesicles containing neurotrophin, activated receptors and downstream kinases are transported through axons by the action of dynein, which produces a force towards the end of microtubules.

Evidence910
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10579926
xref: http://identifiers.org/pubmed/12123609
comment: PI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell death and survival. In addition, it may also use metabolic pathways to regulate cell survival.The PI3K/AKT pathway also affects axon diameter and branching (Marcus et al, 2002) and regulates small G proteins like RhoA (Vanhaesebroeck, B and Waterman, MD, 1999), which control the behaviour of the F-actin cytoskeleton. Moreover, through its connection with the TOR pathway, it promotes translation of a subset of mRNAs.

http://identifiers.org/pubmed/10567352
type: PublicationXref
id: 10567352
author: Painter, GF
author: Cooke, FT
author: Holmes, AB
author: McEwen, RK
author: Ohya, Y
author: Shisheva, A
author: Michell, RH
author: Parker, PJ
author: Dove, SK
db: Pubmed
title: Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases
source: J Biol Chem 274:33905-12
year: 1999

http://identifiers.org/pubmed/10401004
type: PublicationXref
id: 10401004
author: Mercer, JF
author: Ambrosini, L
db: Pubmed
title: Defective copper-induced trafficking and localization of the Menkes protein in patients with mild and copper-treated classical Menkes disease
source: Hum Mol Genet 8:1547-55
year: 1999

Evidence948
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: ERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR family members, a single transmembrane domain, and an intracellular domain consisting of an active kinase and a C-tail with multiple tyrosine phosphorylation sites. Inactive ERBB2 is associated with a chaperone heat shock protein 90 (HSP90) and its co-chaperone CDC37 (Xu et al. 2001, Citri et al. 2004, Xu et al. 2005). In addition, ERBB2 is associated with ERBB2IP (also known as ERBIN or LAP2), a protein responsible for proper localization of ERBB2. In epithelial cells, ERBB2IP restricts expression of ERBB2 to basolateral plasma membrane regions (Borg et al. 2000). ERBB2 becomes activated by forming a heterodimer with another ligand-activated EGFR family member, either EGFR, ERBB3 or ERBB4, which is accompanied by dissociation of chaperoning proteins HSP90 and CDC37 (Citri et al. 2004), as well as ERBB2IP (Borg et al. 2000) from ERBB2. ERBB2 heterodimers function to promote cell proliferation, cell survival and differentiation, depending on the cellular context. ERBB2 can also be activated by homodimerization when it is overexpressed, in cancer for example. In cells expressing both ERBB2 and EGFR, EGF stimulation of EGFR leads to formation of both ERBB2:EGFR heterodimers (Wada et al. 1990, Karunagaran et al. 1996) and EGFR homodimers. Heterodimers of ERBB2 and EGFR trans-autophosphorylate on twelve tyrosine residues, six in the C-tail of EGFR and six in the C-tail of ERBB2 - Y1023, Y1139, Y1196, Y1221, Y1222 and Y1248 (Margolis et al. 1989, Hazan et al. 1990,Walton et al. 1990, Helin et al. 1991, Ricci et al. 1995, Pinkas-Kramarski 1996). Phosphorylated tyrosine residues in the C-tail of EGFR and ERBB2 serve as docking sites for downstream signaling molecules. Three key signaling pathways activated by ERBB2:EGFR heterodimers are RAF/MAP kinase cascade, PI3K-induced AKT …

Evidence947
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19933325
comment: E3 ubiquitin ligase Cullin-5 (CUL5) is recruited to the ERBB2 site at the plasma membrane and ubiquitinates ERBB2 in an HSP90-dependent way, targeting it for degradation. Ubiquitination of ERBB2 by CUL5 appears to be independent of CUL5 adaptor proteins ElonginB and ElonginC.

Evidence946
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12239347
comment: E3 ubiquitin ligase CHIP (STUB1) mediates ERBB2 ubiquitination by associating with the ERBB2 indirectly, through the chaperone protein HSP90. CHIP (STUB1) ubiquitinates both ERBB2 and HSP90, leading to their proteasome-dependent degradation. Ubiquitination of ERBB2 by CHIP (STUB1) is independent of ERBB2 activation.

Evidence945
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Level of plasma membrane ERBB3 is regulated by E3 ubiquitin ligase RNF41 (also known as NRDP1), which binds and ubiquitinates both inactive and activated ERBB3, targeting it for degradation (Cao et al. 2007). RNF41 is subject to self-ubiquitination which keeps its levels low when ERBB3 is not stimulated, and preserves ERBB3 expression on the cell surface (Qiu et al. 2002). Self-ubiquitination of RNF41 is reversible, through the action of ubiquitin protease USP8, an enzyme stabilized by AKT-mediated phosphorylation. Therefore, activation of AKT by ERBB2:ERBB3 signaling leads to phosphorylation of USP8 (Cao et al. 2007), which increases level of RNF41 through deubiquitination, and results in degradation of activated ERBB3 (Cao et al. 2007) - a negative feedback loop of ERBB3 signaling. Downregulation of EGFR and ERBB4 signaling is explained in pathways Signaling by EGFR and Signaling by ERBB4.

http://identifiers.org/pubmed/3053703
type: PublicationXref
id: 3053703
author: Meister, A
db: Pubmed
title: Glutathione metabolism and its selective modification
source: J Biol Chem 263:17205-8
year: 1988

http://identifiers.org/pubmed/3053705
type: PublicationXref
id: 3053705
author: Sample, C
author: Bell, GI
author: Sanke, T
author: Rubenstein, AH
author: Steiner, DF
db: Pubmed
title: An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing
source: J Biol Chem 263:17243-6
year: 1988

Evidence949
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: All splicing isoforms of ERBB4 possess two tyrosine residues in the C-tail that serve as docking sites for SHC1 (Kaushansky et al. 2008, Pinkas-Kramarski et al. 1996, Cohen et al. 1996). Once bound to ERBB4, SHC1 becomes phosphorylated on tyrosine residues by the tyrosine kinase activity of ERBB4, which enables it to recruit the complex of GRB2 and SOS1, resulting in the guanyl-nucleotide exchange on RAS and activation of RAF and MAP kinase cascade (Kainulainen et al. 2000).

Evidence940
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12411582
comment: RNF41 is able to self-ubiquitinate, which keeps its levels low when ERBB3 is unstimulated.

Evidence944
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17210635
comment: RNF41 ubiquitinates activated ERBB3, thereby downregulating ERBB3-mediated signaling. This reaction is part of a negative feedback loop in ERBB2:ERBB3 signaling.

Evidence943
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17210635
comment: Phosphorylated USP8 deubiquitinates RNF41 and increases RNF41 level in the cell.

Evidence942
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17210635
comment: Ubiquitinated RNF41 binds deubiquitinating enzyme USP8, previously activated by phosphorylation on threonine residue T945.

Evidence941
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17210635
comment: Activated AKT phosphorylates USP8, thereby stabilizing it and allowing it to deubiquitinate NRDP1, which results in increased NRDP1 level and downregulation of ERBB3. This represents a negative feedback loop in ERBB3-mediated signaling.

http://identifiers.org/pubmed/6459901
type: PublicationXref
id: 6459901
author: Davis, AE 3rd
author: Kenney, DM
db: Pubmed
title: Association of alternative complement pathway components with human blood platelets: secretion and localization of factor D and beta 1H Globulin
source: Clin Immunol Immunopathol 21:351-63
year: 1981

Evidence935
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: ERBB2:EGFR and ERBB2:ERBB4 can directly recruit GRB2:SOS1 complex through phosphorylated C-tail tyrosines of EGFR (Y1068 and Y1086) and ERBB2 (Y1139) that serve as docking sites for GRB2 (Xie et al. 1995, Sepp-Lorenzino et al. 1996), which, again, results in SOS1-mediated guanyl-nucleotide exchange on RAS and activation of RAF and MAP kinases (Janes et al. 1994, Sepp-Lorenzino et al. 1996).

Evidence934
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: All ERBB2 heterodimers, ERBB2:EGFR, ERBB2:ERBB3 and ERBB2:ERBB4, are able to activate RAF/MAP kinase cascade by recruiting SHC1 (Pinkas-Kramarski et al. 1996, Sepp-Lorenzino et al. 1996) to phosphorylated C-tail tyrosine residues in either EGFR (Y1148 and Y1173), ERBB2 (Y1196, Y1221, Y1222 and Y1248), ERBB3 (Y1328) or ERBB4 (Y1188 and Y1242 in JM-A CYT1 isoform, Y1178 and Y1232 in JM-B CYT1 isoform, Y1172 and Y1226 in JM-A CYT2 isoform). SHC1 recruitment is followed by phosphorylation (Segatto et al. 1993, Soler et al. 1994), and the phosphorylated SHC1 recruits GRB2:SOS1 complex (Xie et al. 1995), which leads to SOS1-mediated guanyl-nucleotide exchange on RAS (Xie et al. 1995) and downstream activation of RAF and MAP kinases.

Mitotic Anaphase
type: Pathway
data source: Reactome
pathway component: REACT 153884.3
pathway component: REACT 162048.2
evidence: Evidence3015
xref: RelationshipXref2084
xref: UnificationXref28683
xref: UnificationXref28682
pathway order: PathwayStep3002
pathway order: PathwayStep3005
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence937
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Activation of PLCG1 signaling is observed only in the presence of ERBB2:EGFR heterodimers, with PLCG1 binding to phosphorylated tyrosine Y992 and Y1173 in the C-tail of EGFR (Chattopadhyay et al. 1999), and potentially Y1023 in the C-tail of ERBB2 (Fazioli et al. 1991, Cohen et al. 1996).

Evidence936
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: ERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated tyrosine residues in the C-tail of ERBB3 (Y1054, Y1197, Y1222, Y1224, Y1276 and Y1289) and ERBB4 CYT1 isoforms (Y1056 in JM-A CYT1 isoform and Y1046 in JM-B CYT1 isoform). Regulatory subunit p85 subsequently recruits catalytic subunit p110 of PI3K, resulting in the formation of active PI3K, conversion of PIP2 to PIP3, and PIP3-mediated activation of AKT signaling (Junttila et al. 2009, Kainulainen et al. 2000). Heterodimers of ERBB2 and EGFR recruit PI3K indirectly, through GRB2:GAB1 complex (Jackson et al. 2004), which again leads to PIP3-mediated activation of AKT signaling.

Evidence939
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17210635
comment: RNF41 ubiquitinates unstimulated ERBB3, targeting it for degradation and regulating ERBB3 level in the cell.

Evidence938
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17210635
comment: RNF41 ubiquitin ligase is able to bind unstimulated ERBB3.

Evidence931
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10582339
xref: http://identifiers.org/pubmed/16483568
comment: SCF induced proliferation is negatively regulated by various proteins including SHP1, PKC, CBL, SOCS1, SOCS6 and LNK.

Evidence930
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7539802
xref: http://identifiers.org/pubmed/10582339
xref: http://identifiers.org/pubmed/16483568
xref: http://identifiers.org/pubmed/7520444
comment: Protein kinase C (PKC) alpha phosphorylates and regulates the activity of several receptor tyrosine kinases including KIT. PKC alpha is involved in a negative feedback loop regulating SCF induced proliferation by phosphorylating and inhibiting the kinase activity of KIT (Blume-Jensen et al. 1994, 1995). PKC alpha phosphorylates KIT on S741 and S746 of the kinase insert (Blume-Jensen et al. 1995). This serine phosphorylation inhibits KIT kinase activity and reduces the capacity of multiple SH2 containing signaling components to associate with KIT (Linnekin 1999).

Evidence933
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8036006
xref: http://identifiers.org/pubmed/8101647
comment: Once bound to ERBB2 heterodimers, SHC1 is phosphorylated on tyrosine residues by the tyrosine kinase activity of either ERBB2 or its heterodimerization partners EGFR and ERBB4.

Evidence932
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17350321
xref: http://identifiers.org/pubmed/16475976
xref: http://identifiers.org/pubmed/19540337
xref: http://identifiers.org/pubmed/2004790
xref: http://identifiers.org/pubmed/16483568
xref: http://identifiers.org/pubmed/15526160
xref: http://identifiers.org/pubmed/7688988
comment: Stem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival and differentiation of hematopoetic progenitors, melanocytes and germ cells.(Linnekin 1999, Rönnstrand 2004, Lennartsson and Rönnstrand 2006). The receptor for SCF is KIT, a tyrosine kinase receptor (RTK) closely related to the receptors for platelet derived growth factor receptor, colony stimulating factor 1 (Linnekin 1999) and Flt3 (Rosnet et al. 1991). Four isoforms of c-Kit have been identified in humans. Alternative splicing results in isoforms of KIT differing in the presence or absence of four residues (GNNK) in the extracellular region. This occurs due to the use of an alternate 5' splice donor site. These GNNK+ and GNNK- variants are co-expressed in most tissues; the GNNK- form predominates and was more strongly tyrosine-phosphorylated and more rapidly internalized (Rönnstrand 2004). There are also splice variants that arise from alternative usage of splice acceptor site resulting in the presence or absence of a serine residue (Crosier et al., 1993). Finally, there is an alternative shorter transcript of KIT expressed in postmeiotic germ cells in the testis which encodes a truncated KIT consisting only of the second part of the kinase domain and thus lackig the extracellular and transmembrane domains as well as the first part of the kinase domain (Rossi et al. 1991). Binding of SCF homodimers to KIT results in KIT homodimerization followed by activation of its intrinsic tyrosine kinase activity. KIT stimulation activates a wide array of signalling pathways including MAPK, PI3K and JAK/STAT (Reber et al. 2006, Rönnstrand 2004). Defects of KIT in humans are associated with different genetic diseases and also in several types of cancers like mast cell leukaemia, germ cell tumours, certain subtypes of malignant melanoma and gastrointestinal tumours.

http://identifiers.org/pubmed/16906134
type: PublicationXref
id: 16906134
author: Lee, JW
author: Ackerman, SL
author: Beebe, K
author: Longo-Guess, CM
author: Davisson, MT
author: Jang, J
author: Schimmel, P
author: Cook, SA
author: Nangle, LA
author: Sundberg, JP
db: Pubmed
title: Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration
source: Nature 443:50-5
year: 2006

http://identifiers.org/pubmed/16906145
type: PublicationXref
id: 16906145
author: Tanaka, TU
author: Helenius, J
author: Tanaka, K
author: Hyman, AA
author: Howard, J
author: Varga, V
db: Pubmed
title: Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner
source: Nat Cell Biol 8:957-62
year: 2006

http://identifiers.org/pubmed/3053686
type: PublicationXref
id: 3053686
author: Rozen, R
author: MacKenzie, RE
author: Bell, AW
author: Hum, DW
db: Pubmed
title: Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.
source: J Biol Chem 263:15946-50
year: 1988

http://identifiers.org/pubmed/16906149
type: PublicationXref
id: 16906149
author: Kim, JY
author: Yuan, JP
author: Zeng, W
author: Muallem, S
author: Huang, GN
author: Worley, PF
author: Han, L
db: Pubmed
title: STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels
source: Nat Cell Biol 8:1003-10
year: 2006

http://identifiers.org/pubmed/16125054
type: PublicationXref
id: 16125054
author: Moens, U
author: Johannessen, M
author: Delghandi, MP
db: Pubmed
title: The cAMP signalling pathway activates CREB through PKA, p38 and MSK1 in NIH 3T3 cells
source: Cell Signal 17:1343-51
year: 2005

UniProt:P36872
type: ProteinReference
xref: UnificationXref5281
organism: BioSource1

SequenceSite19988
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19989
type: SequenceSite
position status: EQUAL
sequence position: 1241

http://identifiers.org/pubmed/9006323
type: PublicationXref
id: 9006323
author: Engström, U
author: Eriksson, L
author: Westermark, P
author: Eneström, S
author: Sletten, K
db: Pubmed
title: Prolactin-derived amyloid in the aging pituitary gland
source: Am J Pathol 150:67-73
year: 1997

SequenceSite19986
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19987
type: SequenceSite
position status: EQUAL
sequence position: 1241

SequenceSite19984
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19985
type: SequenceSite
position status: EQUAL
sequence position: 1241

SequenceSite19982
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19983
type: SequenceSite
position status: EQUAL
sequence position: 1241

SequenceSite19980
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19981
type: SequenceSite
position status: EQUAL
sequence position: 1241

SequenceSite19997
type: SequenceSite
position status: EQUAL
sequence position: 1232

SequenceSite19998
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19999
type: SequenceSite
position status: EQUAL
sequence position: 1232

SequenceSite19993
type: SequenceSite
position status: EQUAL
sequence position: 1232

SequenceSite19994
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19995
type: SequenceSite
position status: EQUAL
sequence position: 1232

SequenceSite19996
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19990
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19991
type: SequenceSite
position status: EQUAL
sequence position: 1232

SequenceSite19992
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/16102047
type: PublicationXref
id: 16102047
author: Coughlin, SR
db: Pubmed
title: Protease-activated receptors in hemostasis, thrombosis and vascular biology
source: J Thromb Haemost 3:1800-14
year: 2005

http://identifiers.org/pubmed/16102045
type: PublicationXref
id: 16102045
author: Ratnikov, BI
author: Ginsberg, MH
author: Partridge, AW
db: Pubmed
title: Integrin activation by talin
source: J Thromb Haemost 3:1783-90
year: 2005

http://identifiers.org/pubmed/16341217
type: PublicationXref
id: 16341217
author: Barton, GM
author: Medzhitov, R
author: Kagan, JC
db: Pubmed
title: Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
source: Nat Immunol 7:49-56
year: 2006

Metabolism of non-coding RNA
type: Pathway
data source: Reactome
pathway component: REACT 129070.5
evidence: Evidence506
xref: RelationshipXref286
xref: UnificationXref5968
xref: UnificationXref5969
pathway order: PathwayStep498
display name: Non-coding RNA Metabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/16102042
type: PublicationXref
id: 16102042
author: Pearce, AC
author: Auger, JM
author: McCarty, OJ
author: Watson, SP
db: Pubmed
title: GPVI and integrin alphaIIb beta3 signaling in platelets
source: J Thromb Haemost 3:1752-62
year: 2005

SequenceSite11308
type: SequenceSite
position status: EQUAL
sequence position: 177

SequenceSite11309
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/16997282
type: PublicationXref
id: 16997282
author: Memet, S
db: Pubmed
title: NF-kappaB functions in the nervous system: from development to disease
source: Biochem Pharmacol 72:1180-95
year: 2006

SequenceSite11304
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11305
type: SequenceSite
position status: EQUAL
sequence position: 177

http://identifiers.org/pubmed/18936096
type: PublicationXref
id: 18936096
author: Thal, DM
author: Kozasa, T
author: Neubig, RR
author: Tesmer, JJ
author: Shankaranarayanan, A
author: Tesmer, VM
author: Roman, DL
db: Pubmed
title: Assembly of high order G alpha q-effector complexes with RGS proteins
source: J Biol Chem 283:34923-34
year: 2008

SequenceSite11306
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11307
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11300
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11301
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11302
type: SequenceSite
position status: EQUAL
sequence position: 177

SequenceSite11303
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11319
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11317
type: SequenceSite
position status: EQUAL
sequence position: 177

SequenceSite11318
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11315
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11316
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11313
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11314
type: SequenceSite
position status: EQUAL
sequence position: 177

SequenceSite11311
type: SequenceSite
position status: EQUAL
sequence position: 177

SequenceSite11312
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11310
type: SequenceSite
position status: EQUAL
sequence position: 584

Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction2049
pathway component: BiochemicalReaction2048
pathway component: BiochemicalReaction2047
pathway component: BiochemicalReaction2050
evidence: Evidence2953
xref: UnificationXref28117
xref: RelationshipXref2042
xref: UnificationXref28118
pathway order: PathwayStep2945
pathway order: PathwayStep2946
pathway order: PathwayStep2944
pathway order: PathwayStep2943
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite11322
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11323
type: SequenceSite
position status: EQUAL
sequence position: 177

SequenceSite11324
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11325
type: SequenceSite
position status: EQUAL
sequence position: 584

SequenceSite11326
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11327
type: SequenceSite
position status: EQUAL
sequence position: 794

SequenceSite11328
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11329
type: SequenceSite
position status: EQUAL
sequence position: 787

SequenceSite11321
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11320
type: SequenceSite
position status: EQUAL
sequence position: 177

UniProt:B3DMN1
type: ProteinReference
xref: UnificationXref7303
organism: BioSource1

SequenceSite11335
type: SequenceSite
position status: EQUAL
sequence position: 822

SequenceSite11336
type: SequenceSite
position status: EQUAL
sequence position: 252

SequenceSite11333
type: SequenceSite
position status: EQUAL
sequence position: 252

SequenceSite11334
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11339
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11337
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11338
type: SequenceSite
position status: EQUAL
sequence position: 822

UniProt:Q05733
type: ProteinReference
xref: UnificationXref26656
organism: BioSource1

SequenceSite11332
type: SequenceSite
position status: EQUAL
sequence position: 787

SequenceSite11331
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite11330
type: SequenceSite
position status: EQUAL
sequence position: 699

Synthesis of PIPs at the late endosome membrane
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction1634
pathway component: BiochemicalReaction1638
pathway component: BiochemicalReaction1636
pathway component: BiochemicalReaction1633
pathway component: BiochemicalReaction1637
pathway component: BiochemicalReaction1635
evidence: Evidence2421
xref: RelationshipXref1327
xref: UnificationXref23598
xref: UnificationXref23599
pathway order: PathwayStep2413
pathway order: PathwayStep2415
pathway order: PathwayStep2410
pathway order: PathwayStep2411
pathway order: PathwayStep2414
pathway order: PathwayStep2412
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:B3DMK8
type: ProteinReference
xref: UnificationXref27926
organism: BioSource1

http://identifiers.org/pubmed/18678864
type: PublicationXref
id: 18678864
author: Esaki, M
author: Kuroyanagi-Hasegawa, M
author: Yokota, M
author: Endo, T
author: Yamano, K
db: Pubmed
title: Step-size analyses of the mitochondrial Hsp70 import motor reveal the Brownian ratchet in operation
source: J Biol Chem 283:27325-32
year: 2008

http://identifiers.org/pubmed/1902783
type: PublicationXref
id: 1902783
author: Talbot, D
author: Grosveld, F
db: Pubmed
title: The 5'HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites
source: EMBO J 10:1391-8
year: 1991

SequenceSite11392
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11391
type: SequenceSite
position status: EQUAL
sequence position: 253

SequenceSite11394
type: SequenceSite
position status: EQUAL
sequence position: 253

SequenceSite11393
type: SequenceSite
position status: EQUAL
sequence position: 822

SequenceSite11396
type: SequenceSite
position status: EQUAL
sequence position: 822

SequenceSite11395
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11398
type: SequenceSite
position status: EQUAL
sequence position: 587

SequenceSite11397
type: SequenceSite
position status: EQUAL
sequence position: 467

Toll Like Receptor TLR6:TLR2 Cascade
type: Pathway
data source: Reactome
pathway component: REACT 92018.9
evidence: Evidence3248
xref: UnificationXref31655
xref: UnificationXref31654
xref: RelationshipXref2251
pathway order: PathwayStep3232
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite11390
type: SequenceSite
position status: EQUAL
sequence position: 821

UniProt:B3DN53
type: ProteinReference
xref: UnificationXref28507
organism: BioSource1

SequenceSite11399
type: SequenceSite
position status: EQUAL
sequence position: 589

UnificationXref15294
type: UnificationXref
id: 4170769
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170769

SequenceSite11383
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref15295
type: UnificationXref
id: 4170771
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170771

SequenceSite11382
type: SequenceSite
position status: EQUAL
sequence position: 821

UnificationXref15296
type: UnificationXref
id: REACT_135346
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135346.5

SequenceSite11381
type: SequenceSite
position status: EQUAL
sequence position: 21

UnificationXref15297
type: UnificationXref
id: CHEBI:594834
db: ChEBI

SequenceSite11380
type: SequenceSite
position status: EQUAL
sequence position: 290

UnificationXref15290
type: UnificationXref
id: REACT_140363
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140363.5

SequenceSite11387
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref15291
type: UnificationXref
id: 4170766
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170766

SequenceSite11386
type: SequenceSite
position status: EQUAL
sequence position: 821

UnificationXref15292
type: UnificationXref
id: 4170767
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170767

SequenceSite11385
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref15293
type: UnificationXref
id: 4170768
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170768

SequenceSite11384
type: SequenceSite
position status: EQUAL
sequence position: 821

UnificationXref15298
type: UnificationXref
id: 1839035
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1839035

UnificationXref15299
type: UnificationXref
id: REACT_125075
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125075.1

UniProt:B3DN64
type: ProteinReference
xref: UnificationXref9296
organism: BioSource1

SequenceSite11388
type: SequenceSite
position status: EQUAL
sequence position: 821

SequenceSite11389
type: SequenceSite
position status: EQUAL
sequence position: 22

UniProt:B3DN70
type: ProteinReference
xref: UnificationXref17731
organism: BioSource1

L-glutamyl-5-poly(ADP-ribose)
type: SequenceModificationVocabulary
xref: UnificationXref2878

UnificationXref15269
type: UnificationXref
id: 4164303
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164303

UnificationXref15268
type: UnificationXref
id: Q9VPT9
db: UniProt

UnificationXref15267
type: UnificationXref
id: 4164301
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164301

UnificationXref15266
type: UnificationXref
id: Q8T0C2
db: UniProt

UnificationXref15265
type: UnificationXref
id: 4164299
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164299

UnificationXref15264
type: UnificationXref
id: Q2PDW1
db: UniProt

UnificationXref15263
type: UnificationXref
id: 4164294
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164294

UnificationXref15262
type: UnificationXref
id: 4164293
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164293

UnificationXref15261
type: UnificationXref
id: FBpp0072525
db: Ensembl

SequenceSite11350
type: SequenceSite
position status: EQUAL
sequence position: 822

UnificationXref15260
type: UnificationXref
id: 4164288
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164288

SequenceSite11351
type: SequenceSite
position status: EQUAL
sequence position: 656

SequenceSite11352
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11353
type: SequenceSite
position status: EQUAL
sequence position: 822

SequenceSite11354
type: SequenceSite
position status: EQUAL
sequence position: 656

SequenceSite11356
type: SequenceSite
position status: EQUAL
sequence position: 822

SequenceSite11355
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11358
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11357
type: SequenceSite
position status: EQUAL
sequence position: 546

UniProt:B3DMP9
type: ProteinReference
xref: UnificationXref1719
organism: BioSource1

http://identifiers.org/pubmed/3061785
type: PublicationXref
id: 3061785
author: Duckworth, WC
db: Pubmed
title: Insulin degradation: mechanisms, products, and significance.
source: Endocr Rev 9:319-45
year: 1989

SequenceSite11359
type: SequenceSite
position status: EQUAL
sequence position: 822

http://identifiers.org/pubmed/11564948
type: PublicationXref
id: 11564948
author: Sánchez-Jiménez, F
author: Urdiales, JL
author: Medina, MA
db: Pubmed
title: Polyamine metabolism revisited
source: Eur J Gastroenterol Hepatol 13:1015-9
year: 2001

UnificationXref15259
type: UnificationXref
id: P37160
db: UniProt

UnificationXref15258
type: UnificationXref
id: 4164283
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164283

UnificationXref15255
type: UnificationXref
id: Q4V5P7
db: UniProt

UnificationXref15254
type: UnificationXref
id: 4164277
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164277

UnificationXref15257
type: UnificationXref
id: C0HBU0
db: UniProt

UnificationXref15256
type: UnificationXref
id: 4164280
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164280

UnificationXref15251
type: UnificationXref
id: A1ZBX7
db: UniProt

UnificationXref15250
type: UnificationXref
id: 4164271
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164271

SLC16A10-mediated uptake of aromatic amino acids
type: BiochemicalReaction
data source: Reactome
evidence: Evidence12
xref: UnificationXref311
xref: UnificationXref310
left: SmallMolecule72
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule73

UnificationXref15253
type: UnificationXref
id: C5WLP0
db: UniProt

Vesicular inhibitory amino acid transport
type: BiochemicalReaction
data source: Reactome
evidence: Evidence11
xref: UnificationXref297
xref: UnificationXref298
left: SmallMolecule67
left: SmallMolecule61
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule69
right: SmallMolecule21

UnificationXref15252
type: UnificationXref
id: 4164274
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164274

http://identifiers.org/pubmed/16872679
type: PublicationXref
id: 16872679
author: Pikuleva, IA
db: Pubmed
title: Cytochrome P450s and cholesterol homeostasis
source: Pharmacol Ther 112:761-73
year: 2006

SequenceSite11342
type: SequenceSite
position status: EQUAL
sequence position: 822

SequenceSite11343
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11340
type: SequenceSite
position status: EQUAL
sequence position: 822

SequenceSite11341
type: SequenceSite
position status: EQUAL
sequence position: 22

pyrophosphate + H2O => 2 orthophosphate [mitochondrial]
type: BiochemicalReaction
data source: Reactome
evidence: Evidence2
EC number: 3.6.1.1
xref: UnificationXref32
xref: UnificationXref33
participant stoichiometry: Stoichiometry3
left: SmallMolecule5
left: SmallMolecule6
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule7

SequenceSite11347
type: SequenceSite
position status: EQUAL
sequence position: 22

Glutamate transport
type: BiochemicalReaction
data source: Reactome
evidence: Evidence4
xref: UnificationXref89
xref: UnificationXref90
participant stoichiometry: Stoichiometry6
participant stoichiometry: Stoichiometry5
left: SmallMolecule10
left: SmallMolecule9
left: SmallMolecule11
left: SmallMolecule15
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule20
right: SmallMolecule16
right: SmallMolecule21
right: SmallMolecule22

SequenceSite11346
type: SequenceSite
position status: EQUAL
sequence position: 822

SequenceSite11345
type: SequenceSite
position status: EQUAL
sequence position: 22

pyrophosphate + H2O => 2 orthophosphate [cytosolic]
type: BiochemicalReaction
data source: Reactome
evidence: Evidence1
EC number: 3.6.1.1
xref: UnificationXref16
xref: UnificationXref17
participant stoichiometry: Stoichiometry1
left: SmallMolecule1
left: SmallMolecule2
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule3

SequenceSite11344
type: SequenceSite
position status: EQUAL
sequence position: 822

Sulfate is exported to the cytosol in exchange for dicarboxylate
type: BiochemicalReaction
data source: Reactome
evidence: Evidence8
xref: UnificationXref275
xref: UnificationXref276
left: SmallMolecule64
left: SmallMolecule63
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule66
right: SmallMolecule65

malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]
type: BiochemicalReaction
data source: Reactome
evidence: Evidence9
xref: UnificationXref278
xref: UnificationXref277
left: SmallMolecule3
left: SmallMolecule65
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule7
right: SmallMolecule64

Proton-coupled di- and tri-peptide cotransport
type: BiochemicalReaction
data source: Reactome
evidence: Evidence5
xref: UnificationXref221
xref: UnificationXref222
left: SmallMolecule9
left: Di-peptides/tri-peptides
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Di-peptides/tri-peptides
right: SmallMolecule21

SequenceSite11349
type: SequenceSite
position status: EQUAL
sequence position: 22

Vesicular glutamate transport
type: BiochemicalReaction
data source: Reactome
evidence: Evidence7
xref: UnificationXref243
xref: UnificationXref244
left: SmallMolecule18
left: SmallMolecule61
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule62
right: SmallMolecule21

SequenceSite11348
type: SequenceSite
position status: EQUAL
sequence position: 822

UniProt:B3DMQ0
type: ProteinReference
xref: UnificationXref8443
organism: BioSource1

UnificationXref15289
type: UnificationXref
id: 4170765
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170765

UnificationXref15288
type: UnificationXref
id: 4170764
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170764

UnificationXref15287
type: UnificationXref
id: 4170763
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170763

UnificationXref15282
type: UnificationXref
id: 4164352
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164352

SequenceSite11373
type: SequenceSite
position status: EQUAL
sequence position: 821

UnificationXref15281
type: UnificationXref
id: 4164307
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164307

SequenceSite11374
type: SequenceSite
position status: EQUAL
sequence position: 267

UnificationXref15280
type: UnificationXref
id: 4164306
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164306

SequenceSite11375
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11376
type: SequenceSite
position status: EQUAL
sequence position: 821

UnificationXref15286
type: UnificationXref
id: 4170762
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4170762

UnificationXref15285
type: UnificationXref
id: REACT_137949
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137949.5

SequenceSite11370
type: SequenceSite
position status: EQUAL
sequence position: 822

UnificationXref15284
type: UnificationXref
id: 4175766
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4175766

SequenceSite11371
type: SequenceSite
position status: EQUAL
sequence position: 267

UnificationXref15283
type: UnificationXref
id: REACT_127607
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127607.5

SequenceSite11372
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11378
type: SequenceSite
position status: EQUAL
sequence position: 21

SequenceSite11377
type: SequenceSite
position status: EQUAL
sequence position: 290

SequenceSite11379
type: SequenceSite
position status: EQUAL
sequence position: 821

UniProt:B3DN38
type: ProteinReference
xref: UnificationXref22148
organism: BioSource1

Downregulation of SMAD2/3:SMAD4 transcriptional activity
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction122
pathway component: BiochemicalReaction115
pathway component: Degradation2
pathway component: Degradation3
pathway component: BiochemicalReaction106
pathway component: BiochemicalReaction123
pathway component: BiochemicalReaction119
pathway component: BiochemicalReaction110
pathway component: BiochemicalReaction112
pathway component: BiochemicalReaction117
pathway component: BiochemicalReaction121
pathway component: BiochemicalReaction107
pathway component: BiochemicalReaction114
pathway component: Degradation4
pathway component: BiochemicalReaction118
pathway component: BiochemicalReaction111
pathway component: BiochemicalReaction113
pathway component: BiochemicalReaction120
pathway component: BiochemicalReaction109
pathway component: BiochemicalReaction108
pathway component: BiochemicalReaction116
evidence: Evidence199
xref: UnificationXref2929
xref: UnificationXref2930
xref: RelationshipXref126
pathway order: PathwayStep174
pathway order: PathwayStep180
pathway order: PathwayStep182
pathway order: PathwayStep178
pathway order: PathwayStep184
pathway order: PathwayStep187
pathway order: PathwayStep177
pathway order: PathwayStep190
pathway order: PathwayStep191
pathway order: PathwayStep192
pathway order: PathwayStep181
pathway order: PathwayStep176
pathway order: PathwayStep183
pathway order: PathwayStep179
pathway order: PathwayStep188
pathway order: PathwayStep172
pathway order: PathwayStep173
pathway order: PathwayStep186
pathway order: PathwayStep189
pathway order: PathwayStep185
pathway order: PathwayStep175
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref15277
type: UnificationXref
id: 4164210
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164210

UnificationXref15276
type: UnificationXref
id: 4164208
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164208

UnificationXref15279
type: UnificationXref
id: 4164305
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164305

UnificationXref15278
type: UnificationXref
id: 4164295
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164295

SequenceSite11364
type: SequenceSite
position status: EQUAL
sequence position: 822

SequenceSite11365
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref15271
type: UnificationXref
id: 4164350
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164350

SequenceSite11362
type: SequenceSite
position status: EQUAL
sequence position: 822

UnificationXref15270
type: UnificationXref
id: 4164304
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164304

SequenceSite11363
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref15273
type: UnificationXref
id: 4164174
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164174

SequenceSite11360
type: SequenceSite
position status: EQUAL
sequence position: 546

UnificationXref15272
type: UnificationXref
id: 4164351
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164351

SequenceSite11361
type: SequenceSite
position status: EQUAL
sequence position: 22

UnificationXref15275
type: UnificationXref
id: 4164203
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164203

UnificationXref15274
type: UnificationXref
id: 4164202
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164202

SequenceSite11369
type: SequenceSite
position status: EQUAL
sequence position: 22

http://identifiers.org/pubmed/16176984
type: PublicationXref
id: 16176984
author: Flachsova, E
author: Lee, DS
author: Bodnarova, M
author: Raman, CS
author: Martasek, P
author: Demeler, B
db: Pubmed
title: Structural basis of hereditary coproporphyria
source: Proc Natl Acad Sci U S A 102:14232-7
year: 2005

SequenceSite11368
type: SequenceSite
position status: EQUAL
sequence position: 822

SequenceSite11367
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite11366
type: SequenceSite
position status: EQUAL
sequence position: 822

UnificationXref15229
type: UnificationXref
id: A1ZBX6
db: UniProt

Cell Cycle, Mitotic
type: Pathway
data source: Reactome
pathway component: REACT 93720.9
pathway component: REACT 79481.9
pathway component: REACT 33553.10
pathway component: REACT 93079.9
pathway component: REACT 104892.9
pathway component: REACT 89318.9
pathway component: REACT 101505.9
evidence: Evidence3485
xref: UnificationXref32956
xref: UnificationXref32957
xref: RelationshipXref2324
pathway order: PathwayStep3015
pathway order: PathwayStep3394
pathway order: PathwayStep1932
pathway order: PathwayStep3440
pathway order: PathwayStep1901
pathway order: PathwayStep3405
pathway order: PathwayStep3471
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref15220
type: UnificationXref
id: 4164348
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164348

7alpha,26-dihydroxy-5beta-cholestan-3-one [ChEBI:48778]
type: SmallMoleculeReference
name: 7alpha,26-dihydroxy-5beta-cholestan-3-one
name: 5beta-cholestan-7alpha,27-diol-3-one
name: 5beta-cholestan-7alpha,26-diol-3-one
xref: UnificationXref22678

UnificationXref15225
type: UnificationXref
id: MOD:00026
db: MOD

UnificationXref15226
type: UnificationXref
id: 4164215
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164215

UnificationXref15227
type: UnificationXref
id: P37161
db: UniProt

UnificationXref15228
type: UnificationXref
id: 4164220
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164220

UnificationXref15221
type: UnificationXref
id: 4164349
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164349

UnificationXref15222
type: UnificationXref
id: A1Z8C9
db: UniProt

UnificationXref15223
type: UnificationXref
id: 4164207
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164207

UnificationXref15224
type: UnificationXref
id: P29615
db: UniProt

UnificationXref15219
type: UnificationXref
id: 4164347
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164347

UnificationXref15218
type: UnificationXref
id: Q9VGE9
db: UniProt

UnificationXref15216
type: UnificationXref
id: Q9VGF0
db: UniProt

UnificationXref15217
type: UnificationXref
id: 4164346
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164346

UnificationXref15214
type: UnificationXref
id: Q86B95
db: UniProt

UnificationXref15215
type: UnificationXref
id: 4164345
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164345

UnificationXref15212
type: UnificationXref
id: E8NH85
db: UniProt

UnificationXref15213
type: UnificationXref
id: 4164344
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164344

UnificationXref15210
type: UnificationXref
id: Q86B97
db: UniProt

UnificationXref15211
type: UnificationXref
id: 4164343
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164343

http://identifiers.org/pubmed/19933148
type: PublicationXref
id: 19933148
author: Espenshade, PJ
author: Osborne, TF
db: Pubmed
title: Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been
source: Genes Dev 23:2578-91
year: 2009

UnificationXref15240
type: UnificationXref
id: 4164250
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164250

UnificationXref15241
type: UnificationXref
id: P83972
db: UniProt

UnificationXref15242
type: UnificationXref
id: 4164255
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164255

UnificationXref15243
type: UnificationXref
id: A1ZAB8
db: UniProt

UnificationXref15244
type: UnificationXref
id: 4164260
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164260

UnificationXref15245
type: UnificationXref
id: Q9W4C2
db: UniProt

UnificationXref15246
type: UnificationXref
id: 4164265
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164265

UnificationXref15247
type: UnificationXref
id: C8VV53
db: UniProt

UnificationXref15248
type: UnificationXref
id: 4164268
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164268

UnificationXref15249
type: UnificationXref
id: P83971
db: UniProt

UnificationXref15230
type: UnificationXref
id: 4164225
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164225

UnificationXref15231
type: UnificationXref
id: P37159
db: UniProt

http://identifiers.org/pubmed/14614828
type: PublicationXref
id: 14614828
author: Neumann, D
author: Johnstone, SR
author: Wallimann, T
author: Leiper, FC
author: Dickerson, K
author: Woods, A
author: Schlattner, U
author: Fryer, LG
author: Carlson, M
author: Carling, D
db: Pubmed
title: LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
source: Curr Biol 13:2004-8
year: 2003

UnificationXref15234
type: UnificationXref
id: 4164235
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164235

UnificationXref15235
type: UnificationXref
id: A1Z9D5
db: UniProt

UnificationXref15232
type: UnificationXref
id: 4164230
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164230

UnificationXref15233
type: UnificationXref
id: G2J5Z3
db: UniProt

UnificationXref15238
type: UnificationXref
id: 4164245
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164245

UnificationXref15239
type: UnificationXref
id: Q4QPT0
db: UniProt

UnificationXref15236
type: UnificationXref
id: 4164240
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164240

UnificationXref15237
type: UnificationXref
id: Q08694
db: UniProt

UniProt:B3DN99
type: ProteinReference
xref: UnificationXref29811
organism: BioSource1

http://identifiers.org/pubmed/15474027
type: PublicationXref
id: 15474027
author: Tuckerman, JR
author: Pugh, CW
author: Tian, YM
author: Zhao, Y
author: Ratcliffe, PJ
author: Hewitson, KS
author: Mole, DR
db: Pubmed
title: Determination and comparison of specific activity of the HIF-prolyl hydroxylases
source: FEBS Lett 576:145-50
year: 2004

http://identifiers.org/pubmed/16704971
type: PublicationXref
id: 16704971
author: Harayama, T
author: Hishikawa, D
author: Suwabe, A
author: Ogasawara, R
author: Shimizu, T
author: Taguchi, R
author: Nakanishi, H
author: Shindou, H
db: Pubmed
title: Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production
source: J Biol Chem 281:20140-7
year: 2006

http://identifiers.org/pubmed/8987985
type: PublicationXref
id: 8987985
author: Gould, GW
author: Arbuckle, MI
author: Porter, LM
author: Kane, S
author: Seatter, MJ
db: Pubmed
title: Structure-function analysis of liver-type (GLUT2) and brain-type (GLUT3) glucose transporters: expression of chimeric transporters in Xenopus oocytes suggests an important role for putative transmembrane helix 7 in determining substrate selectivity
source: Biochemistry 35:16519-27
year: 1996

UniProt:B3DMZ9
type: ProteinReference
xref: UnificationXref9210
organism: BioSource1

UnificationXref15207
type: UnificationXref
id: 4164341
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164341

UnificationXref15208
type: UnificationXref
id: E8NH73
db: UniProt

UnificationXref15209
type: UnificationXref
id: 4164342
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164342

ATM mediated phosphorylation of repair proteins
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction925
evidence: Evidence1444
xref: UnificationXref14422
xref: UnificationXref14421
pathway order: PathwayStep1440
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref15200
type: UnificationXref
id: Q86B96
db: UniProt

UnificationXref15202
type: UnificationXref
id: Q86B94
db: UniProt

http://identifiers.org/pubmed/15474001
type: PublicationXref
id: 15474001
author: Woscholski, R
author: Mitchell, CA
author: Nussbaum, R
author: Wise, HM
author: Schmid, AC
db: Pubmed
title: Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation
source: FEBS Lett 576:9-13
year: 2004

UnificationXref15201
type: UnificationXref
id: 4164338
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164338

UnificationXref15204
type: UnificationXref
id: D3DMM4
db: UniProt

UnificationXref15203
type: UnificationXref
id: 4164339
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164339

UnificationXref15206
type: UnificationXref
id: E6PBY2
db: UniProt

UnificationXref15205
type: UnificationXref
id: 4164340
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4164340

http://identifiers.org/pubmed/18728184
type: PublicationXref
id: 18728184
author: Henry, K
author: Elliott, MH
author: Anderson, RE
author: Agbaga, MP
author: Mandal, MN
author: Brush, RS
db: Pubmed
title: Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids
source: Proc Natl Acad Sci U S A 105:12843-8
year: 2008

http://identifiers.org/pubmed/16704978
type: PublicationXref
id: 16704978
author: Varoqueaux, F
author: Andrews-Zwilling, YS
author: Reim, K
author: Kawabe, H
author: Brose, N
db: Pubmed
title: Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2
source: J Biol Chem 281:19720-31
year: 2006

http://identifiers.org/pubmed/6467990
type: PublicationXref
id: 6467990
author: Gorska, D
author: Fidzianska, E
author: Glogowska, I
author: Abramowicz, T
author: Rodo, M
author: Czartoryska, B
db: Pubmed
title: Assignment of the gene for human arylsulfatase B, ARSB, to chromosome region 5p11----5qter
source: Cytogenet. Cell Genet. 38:150-1
year: 1984

Activation of the pre-replicative complex
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction1240
pathway component: BiochemicalReaction1236
pathway component: BiochemicalReaction1238
pathway component: BiochemicalReaction1237
pathway component: BiochemicalReaction1242
pathway component: BiochemicalReaction1241
pathway component: BiochemicalReaction1239
pathway component: BiochemicalReaction1235
evidence: Evidence1899
xref: UnificationXref19245
xref: UnificationXref19244
pathway order: PathwayStep1892
pathway order: PathwayStep1897
pathway order: PathwayStep1896
pathway order: PathwayStep1893
pathway order: PathwayStep1891
pathway order: PathwayStep1894
pathway order: PathwayStep1895
pathway order: PathwayStep1898
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/20581824
type: PublicationXref
id: 20581824
author: Williams, SP
author: Hu, X
author: Bynum, J
author: Lambert, MH
author: Lazar, MA
author: Nolte, RT
author: Broderick, TM
author: Gampe RT, Jr
author: Parks, DJ
author: Phelan, CA
author: Montana, V
db: Pubmed
title: Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction
source: Nat Struct Mol Biol 17:808-14
year: 2010

SequenceSite19881
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19882
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19880
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19885
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19886
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19883
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19884
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19889
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19887
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19888
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/18694939
type: PublicationXref
id: 18694939
author: Siniossoglou, S
author: Rochford, JJ
author: Carman, GM
author: Grimsey, N
author: Han, GS
author: O'Hara, L
db: Pubmed
title: Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2
source: J Biol Chem 283:29166-74
year: 2008

Formation of transcription-coupled NER (TC-NER) repair complex
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction939
pathway component: BiochemicalReaction938
evidence: Evidence1477
xref: UnificationXref14605
xref: UnificationXref14606
pathway order: PathwayStep1473
pathway order: PathwayStep1472
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

SequenceSite19890
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19891
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19892
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19893
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19894
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19895
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19896
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19897
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19898
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19899
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19869
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19860
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19867
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19868
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19865
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19866
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19863
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19864
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19861
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19862
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/8104191
type: PublicationXref
id: 8104191
author: Vainberg, IE
author: Chow, RL
author: Melki, R
author: Cowan, NJ
db: Pubmed
title: Chaperonin-mediated folding of vertebrate actin-related protein and gamma-tubulin
source: J Cell Biol 122:1301-10
year: 1993

http://identifiers.org/pubmed/12007602
type: PublicationXref
id: 12007602
author: Pabarcus, MK
author: Casida, JE
db: Pubmed
title: Kynurenine formamidase: determination of primary structure and modeling-based prediction of tertiary structure and catalytic triad.
source: Biochim Biophys Acta 1596:201-11
year: 2002

SequenceSite19870
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19871
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19876
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19877
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19878
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite19879
type: SequenceSite
position status: EQUAL
sequence position: 1531

SequenceSite19872
type: SequenceSite
position status: EQUAL
sequence position: 1