UniProt:Q55EK9
type: ProteinReference
xref: UnificationXref8732
organism: Dictyostelium discoideum

Evidence1261
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9630604
xref: http://identifiers.org/pubmed/20153287
xref: http://identifiers.org/pubmed/22123817
comment: Once biotinylated, three halocarboxylases (hCBXs) are localised to the mitochondrial matrix. The mechanism of transfer is still unclear. Pyruvate carboxylase (PC) is required for gluconeogenesis, lipogenesis, neurotransmitter synthesis and insulin secretion; Methylcrotonyl-CoA carboxylase (MCC) is required for amino acid metabolism; propionyl-CoA carboxylase (PCC) is required for odd-chain fatty acid oxidation (Ingaramo & Beckett 2012, Hiratsuka et al. 1998, Bailey et al. 2010).

Evidence1262
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16326698
xref: http://identifiers.org/pubmed/16134170
xref: http://identifiers.org/pubmed/9630604
xref: http://identifiers.org/pubmed/20153287
xref: http://identifiers.org/pubmed/20952656
xref: http://identifiers.org/pubmed/12360400
xref: http://identifiers.org/pubmed/22123817
comment: Biotin (Btn) acts as a coenzyme to 4 carboxylases which exist in their inactive apo forms. In the cytosol, these apo carboxylases are biotinylated to their active halo forms by the activity of biotin-protein ligase (HCLS) (Ingaramo & Beckett 2012, Hiratsuka et al. 1998, Bailey et al. 2010). Defects in HLCS causes holocarboxylase synthetase deficiency (HLCS deficiency aka biotin-responsive multiple carboxylase deficiency; MIM:253270). HLCS deficiency is an autosomal recessive disorder whereby deficient HLCS activity results in reduced activity of multiple carboxylases. Symptoms include metabolic acidosis, organic aciduria, lethargy, hypotonia, convulsions and dermatitis (Suzuki et al. 2005). Acetyl-CoA carboxylases 1 and 2 (ACACA and ACACB) bind 2 Mn2+ and 1 Btn per subunit (Colbert et al. 2010). They can exist as either monomers, homodimers or homotetramers (latter two not shown in this reaction) (Magnard et al. 2002, Moreau et al. 2006). Unlike the other carboxylases acted upon by HCLS, ACACA and B are located in the cytosol (shown here) as well as the mitochondrial membrane. The exact order in which this complex is constructed is unknown.

Evidence1260
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16134170
xref: http://identifiers.org/pubmed/9630604
xref: http://identifiers.org/pubmed/20153287
xref: http://identifiers.org/pubmed/22123817
comment: Biotin (Btn) acts as a coenzyme to 4 carboxylases which exist in their inactive apo forms. In the cytosol, these apo carboxylases are biotinylated to their active halo forms by the activity of biotin-protein ligase (HCLS) (Ingaramo & Beckett 2012, Hiratsuka et al. 1998, Bailey et al. 2010). Defects in HLCS causes holocarboxylase synthetase deficiency (HLCS deficiency aka biotin-responsive multiple carboxylase deficiency; MIM:253270). HLCS deficiency is an autosomal recessive disorder whereby deficient HLCS activity results in reduced activity of multiple carboxylases. Symptoms include metabolic acidosis, organic aciduria, lethargy, hypotonia, convulsions and dermatitis (Suzuki et al. 2005). Methylcrotonoyl-CoA carboxylase is most likely functional as a dodecamer, composed of 6 Btn-containing alpha subunits (MCCC1) and six beta subunits (MCCC2). The exact order in which this complex is constructed is unknown.

Evidence1265
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9473669
comment: The enzyme, nicotinate nucleotide pyrophosphorylase, is specific for quinolinate. Its activity is strictly dependent on Mg2+ ions being present. A phosphoribosyl group is transferred to quinolinate to form nicotinate D-ribonucleotide. This reaction represents another rate-limiting step of the pathway from tryptophan to NAD+.

Evidence1266
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16118205
xref: http://identifiers.org/pubmed/11788603
xref: http://identifiers.org/pubmed/11248244
xref: http://identifiers.org/pubmed/17402747
comment: NMNAT1 catalyzes the reaction of nicotinate D-ribonucleotide and ATP to form deamino-NAD+ (nicotinate adenine dinucleotide) and pyrophosphate (Schweiger et al. 2001). The active form of the enzyme in vitro is a hexamer (Zhou et al. 2002), and its activity is substantially greater in the presence of Zn++ than of Mg++ (Sorci et al. 2007). The predicted amino acid sequence of the enzyme contains a nuclear localization domain and the protein is observed to localize to the nucleus (Schweiger et al. 2001; Berger et al. 2005).

Evidence1263
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6883721
xref: http://identifiers.org/pubmed/7509806
xref: http://identifiers.org/pubmed/7758201
comment: Human biotinidase (BTD) (Cole et al. 1994) is a secreted enzyme that catalyzes the hydrolysis of biocytin (BCTN), the product of biotin-dependent carboxylase degradation, to biotin (Btn) and lysine. BTD deficiency, an autosomal recessive disorder, results in a secondary Btn deficiency that leads to late-onset multiple carboxylase deficiency (MIM:253260) (Wolf et al. 1983).

Evidence1264
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19319844
comment: Biotin (Btn) is an essential cofactor in a variety of carboxylation reactions (Zempleni et al. 2009). Humans cannot synthesize Btn but it is abundant in the human diet and can be taken up from the intestinal lumen by the SLC5A6 transporter. Its uptake, intracellular translocation, covalent conjugation to apoenzymes, and salvage are described here.

Evidence1269
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12547821
comment: NAD synthase catalyzes the final step in the biosynthesis of NAD+, both in the de novo synthesis and in the salvage pathways. The enzyme makes use of glutamine as an amide donor in the reaction. NAD synthase exists as a homohexamer in the cytosol. There are two forms of NAD synthase in humans, NADsyn1 and NADsyn2. The major difference between the two forms is that NADsyn1 appears to be glutamine-dependent whereas NADsyn2 is strictly ammonia-dependent.

Evidence1267
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14516279
xref: http://identifiers.org/pubmed/12359228
xref: http://identifiers.org/pubmed/16118205
xref: http://identifiers.org/pubmed/17402747
comment: NMNAT2 catalyzes the reaction of nicotinate D-ribonucleotide and ATP to form deamino-NAD+ (nicotinate adenine dinucleotide) and pyrophosphate (Sorci et al. 2007). The active form of the enzyme is a monomer in vitro (Raffaelli et al. 2002). Although the predicted amino acid sequence of the enzyme lacks an obvious signal sequence or transmembrane domain (Yalowitz et al. 2004), recombinant FLAG-tagged protein expressed in HeLa cells localizes predominantly to the Golgi apparatus (Berger et al. 2005). Its localization within the Golgi apparatus is unknown and the annotation here is based on the plausible but speculative assumption that the enzyme is associated with the Gogi membrane and accessible from the cytosol. Immunostaining studies indicate that the protein is abundant in Islets of Langerhans and in several regions of the brain (Yalowitz et al. 2004).

Evidence1268
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16118205
xref: http://identifiers.org/pubmed/12574164
xref: http://identifiers.org/pubmed/17402747
comment: NMNAT3 catalyzes the reaction of nicotinate D-ribonucleotide and ATP to form deamino-NAD+ (nicotinate adenine dinucleotide) and pyrophosphate (Sorci et al. 2007). The active form of the enzyme is a tetramer in vitro (Zhang et al. 2003). Recombinant FLAG-tagged protein expressed in HeLa cells localizes both to the cytosol and to mitochondria (Berger et al. 2005). The cytosolic protein is annotated here.

http://identifiers.org/pubmed/11903050
type: PublicationXref
id: 11903050
author: MacMullen, CM
author: Smith, TJ
author: Poncz, M
author: Hsu, BY
author: Fang, J
author: Stanley, CA
db: Pubmed
title: Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
source: Biochem J 363:81-7
year: 2002

http://identifiers.org/pubmed/9809442
type: PublicationXref
id: 9809442
author: Marin-Garcia, J
author: Ananthakrishnan, R
author: Goldenthal, MJ
db: Pubmed
title: Cloning and molecular analysis of the human citrate synthase gene
source: Genome 41:733-738
year: 1998

Evidence1280
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8662720
xref: http://identifiers.org/pubmed/10978331
comment: SLC25A32 protein in the inner mitochondrial membrane mediates the reversible transport of tetrahydrofolate between the cytosol and the mitochondrial matrix. Retention of tetrahydrofolate within the mitochondrial matrix is dependent on mitochondrial polyglutamate addition (Titus and Moran 2000; Chen et al. 1996).

Evidence1270
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11594753
comment: NAD+ kinase catalyzes the transfer of a phosphate group from ATP to NAD+, forming NADP+. This is the only way to generate NADP+ in all living organisms. The enzyme requires a divalent metal to be effective. Zn2+ is the best metal for this purpose.

Evidence1271
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/13563527
xref: http://identifiers.org/pubmed/4349867
xref: http://identifiers.org/pubmed/17604275
comment: Cytosolic nicotinate phosphoribosyltransferase (NaPRT) catalyzes the Mg++-dependent reaction of nicotinate and phosphoribosyl pyrophosphate to form nicotinate mononucleotide (NaMN, nicotinate D-ribonucleotide) and pyrophosphate. The active form of the enzyme is a homodimer (Preiss and Handler 1958; Niedel and Dietrich 1973; Hara et al. 2007).

Evidence1272
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14704851
comment: Nicotinamide levels are modulated by the action of three enzymes involved in nicotinamide salvaging. They are nicotinamide deaminase, nicotinamide phosphoribosyltransferase and nicotinate phosphoribosyltransferase. These enzymes are poorly characterized in humans, depsite their importance in nicotinamide utilization.

Evidence1273
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14704851
comment: Nicotinate (niacin) and nicotinamide are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). When NAD+ and NADP+ are interchanged in a reaction with their reduced forms, NADH and NADPH respectively, they are important cofactors in several hundred redox reactions. Nicotinate is synthesized from 2-amino-3-carboxymuconate semialdehyde, an intermediate in the catabolism of the essential amino acid tryptophan.

Evidence1274
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7852378
xref: http://identifiers.org/pubmed/10347183
comment: SLC19A1 protein, associated with the plasma membrane, mediates the uptake of extracellular 5-methyltetrahydrofolate and other reduced folates (Williams and Flintoff 1995; Ferguson and Flintoff 1999).

Evidence1275
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2248959
xref: http://identifiers.org/pubmed/6323448
comment: Cytosolic dihydrofolate reductase catalyzes the reaction of folate, NADPH, and H+ to form dihydrofolate and NADP+ (Chen et al. 1984; Davies et al. 1990).

Evidence1276
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2248959
xref: http://identifiers.org/pubmed/6323448
comment: Cytosolic dihydrofolate reductase catalyzes the reaction of dihydrofolate, NADPH, and H+ to form tetrahydrofolate (THF) and NADP+ (Chen et al. 1984; Davies et al. 1990).

Evidence1277
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8662720
xref: http://identifiers.org/pubmed/1409616
comment: Cytosolic folylpolyglutamate synthase catalyzes the reaction of THF-glutamate(n), L-glutamate, and ATP to form THF-glutamate(n+1), ADP, and orthophosphate. (The first glutamate residue is attached to the glutamate moiety of THF itself; for convenience the process is annotated here as if it proceeded in a single concerted step.) The extent of conjugation is variable, but the commonest cytosolic form of THF has five added glutamate residues. Although its properties as a donor of one-carbon units are not affected by glutamate addition, THF that lacks added glutamate residues cannot be retained in the cytosol so this reaction is needed for normal THF function under physiological conditions (Garrow et al. 1992; Chen et al. 1996).

http://identifiers.org/pubmed/10676816
type: PublicationXref
id: 10676816
author: Cerione, RA
author: Nassar, N
author: Hoffman, GR
db: Pubmed
title: Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI
source: Cell 100:345-56
year: 2000

Evidence1278
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8662720
xref: http://identifiers.org/pubmed/1409616
comment: Cytosolic folylpolyglutamate synthase catalyzes the reaction of 5-methylTHF-glutamate(n), L-glutamate, and ATP to form 5-methylTHF-glutamate(n+1), ADP, and orthophosphate. (The first glutamate residue is attached to the glutamate moiety of 5-methylTHF itself; for convenience the process is annotated here as if it proceeded in a single concerted step.) The extent of conjugation is variable, but the commonest cytosolic form of 5-methylTHF has five added glutamate residues. Although its properties as a donor of one-carbon units are not affected by glutamate addition, 5-methylTHF that lacks added glutamate residues cannot be retained in the cytosol so this reaction is needed for normal 5-methylTHF function under physiological conditions (Garrow et al. 1992; Chen et al. 1996).

http://identifiers.org/pubmed/8662638
type: PublicationXref
id: 8662638
author: Wilson, MP
author: Majerus, PW
db: Pubmed
title: Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme
source: J Biol Chem 271:11904-10
year: 1996

Evidence1279
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8662720
xref: http://identifiers.org/pubmed/10978331
comment: SLC25A32 protein in the inner mitochondrial membrane mediates the reversible transport of tetrahydrofolate between the cytosol and the mitochondrial matrix. Retention of tetrahydrofolate within the mitochondrial matrix is dependent on mitochondrial polyglutamate addition (Titus and Moran 2000; Chen et al. 1996).

Evidence1291
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18650437
comment: Sulfur transfer onto MOCS2A is closely preceded by its adenylylation and deadenylylation. After release of MOCS2A-CO-S(1-), two cysteines on MOCS3 form a disulfide bridge. This means that MOCS3 has to be reduced to be able to participate in the next round. The reducing agent is not known (Marelja et al, 2008).

Evidence1290
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18650437
comment: In order to get a sulfur atom for subsequent sulfuration reactions, cysteine is first desulfurated by NFS1 which transfers it onto a cysteine of MOCS3, yielding a protein persulfide (Marelja et al, 2008).

UniProt:P18613
type: ProteinReference
xref: UnificationXref1111
organism: Dictyostelium discoideum

Evidence1287
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3053686
xref: http://identifiers.org/pubmed/3871768
comment: The methenyltetrahydrofolate cyclohydrolase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 5,10-methenylTHF polyglutamate and H2O to form 10-formylTHF polyglutamate. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

Evidence1288
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10466189
xref: http://identifiers.org/pubmed/11001804
comment: Folates are essential cofactors that provide one-carbon moieties in various states of reduction for biosynthetic reactions. Processes annotated here include transport reactions by which folates are taken up by cells and moved intracellularly, folate conjugation with glutamate (required for folate retention within a cell), and some of the key reactions in the generation of reduced folates and one-carbon derivatives of folate.

Evidence1285
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7726158
comment: Cytosolic MTHFR dimer catalyzes the reaction of 5,10-methyleneTHF polyglutamate, NADPH, and H+ to form 5-methylTHF polyglutamate and NADP+. The specificity and importance of this reaction in vivo have been established through the study of patients deficient in the enzyme (Goyette et al. 1995).

Evidence1286
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3053686
xref: http://identifiers.org/pubmed/3871768
comment: The methylenetetrahydrofolate dehydrogenase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 5,10-methyleneTHF polyglutamate and NADP+ to form 5,10-methenylTHF polyglutamate, NADPH, and H+. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

Evidence1283
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3053686
xref: http://identifiers.org/pubmed/3871768
comment: The methenyltetrahydrofolate cyclohydrolase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 10-formylTHF polyglutamate to form 5,10-methenylTHF polyglutamate and H2O. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

Evidence1284
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3053686
xref: http://identifiers.org/pubmed/3871768
comment: The methylenetetrahydrofolate dehydrogenase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 5,10-methenylTHF polyglutamate, NADPH, and H+ to form 5,10-methyleneTHF polyglutamate and NADP+. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

Evidence1281
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8662720
xref: http://identifiers.org/pubmed/1409616
comment: Mitochondrial folylpolyglutamate synthase catalyzes the reaction of THF-glutamate(n), L-glutamate, and ATP to form THF-glutamate(n+1), ADP, and orthophosphate. (The first glutamate residue is attached to the glutamate moiety of THF itself; for convenience the process is annotated here as if it proceeded in a single concerted step.) The extent of conjugation is variable, but the commonest mitochondrial form of THF has six added glutamate residues. Although its properties as a donor of one-carbon units are not affected by glutamate addition, THF that lacks added glutamate residues cannot be retained in the mitochondrial matrix so this reaction is needed for normal THF function under physiological conditions. The mitochondrial and cytosolic forms of folylpolyglutamate synthase are encoded by the same gene - alternative splicing generates mRNA with or without an initial exon encoding a mitochondrial targeting sequence (Garrow et al. 1992; Chen et al. 1996).

Evidence1282
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3053686
xref: http://identifiers.org/pubmed/3871768
comment: The formate-tetrahydrofolate ligase activity of the trifunctional MTHFD1 enzyme catalyzes the reaction of THF polyglutamate, formate, and ATP to form 10-formylTHF polyglutamate, ADP, and orthophosphate. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

Evidence1289
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15180982
xref: http://identifiers.org/pubmed/11891227
comment: GTP cyclizes in a reaction involving radicals of S-adenosylmethionine, catalyzed by the iron-sulfur cluster dimeric MOCS1. The intermediate result is called precursor Z (Hanzelmann et al, 2002; Hanzelmann et al, 2004).

http://identifiers.org/pubmed/642006
type: PublicationXref
id: 642006
author: Gall, JG
author: Blackburn, EH
db: Pubmed
title: A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena
source: J Mol Biol 120:33-53
year: 1978

Evidence1296
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Vitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only in limited amounts by human cells. Vitamins are classified according to their solubility, either fat-soluble or water-soluble. The physiological processes dependent on vitamin-requiring reactions include many aspects of intermediary metabolism, vision, bone formation, and blood coagulation, and vitamin deficiencies are associated with a correspondingly diverse and severe group of diseases. Water-soluble vitamins include ascorbate (vitamin C) and the members of the B group: thiamin (vitamin B1), riboflavin (B2), niacin (B3), pantothenate (B5), pyridoxine (B6), biotin (B7), folate (B9), and cobalamin (B12). Metabolic processes annotated here include the synthesis of thiamin pyrophosphate (TPP) from thiamin (B1), the synthesis of FMN and FAD from riboflavin (B2), the synthesis of nicotinic acid (niacin - B3) from tryptophan, the synthesis of Coenzyme A from pantothenate (B5), and features of the metabolism of folate (B9).

Evidence1297
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Vitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only in limited amounts by human cells. Vitamins are classified according to their solubility, either fat-soluble or water-soluble. The physiological processes dependent on vitamin-requiring reactions include many aspects of intermediary metabolism, vision, bone formation, and blood coagulation, and vitamin deficiencies are associated with a correspondingly diverse and severe group of diseases. The metabolism of water-soluble vitamins and of vitamin D are annotated in Reactome.

Evidence1298
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11863375
xref: http://identifiers.org/pubmed/9119391
xref: http://identifiers.org/pubmed/1931970
comment: Cytosolic glutamic-pyruvate transaminase (alanine aminotransferase) (GPT) catalyzes the reversible reaction of alanine and 2-oxoglutarate (alpha-ketoglutarate) to form pyruvate and glutamate (Sohocki et al. 1997; Yang et al. 2002). The active form of the enzyme is a dimer (Ishiguro et al. 1991) and is inferred to have a molecule of pyridoxal phosphate associated with each monomer. This reaction allows the synthesis of alanine from intermediates of glucose metabolism in a well-fed person. Under fasting conditions, alanine, derived from protein breakdown, can be converted to pyruvate and used to synthesize glucose via the gluconeogenic pathway in liver, or fully oxidized via the TCA cycle in other tissues.

Evidence1299
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11863375
xref: http://identifiers.org/pubmed/9119391
xref: http://identifiers.org/pubmed/1931970
comment: Cytosolic glutamic-pyruvate transaminase (alanine aminotransferase) (GPT) catalyzes the reversible reaction of pyruvate and glutamate to form alanine and 2-oxoglutarate (alpha-ketoglutarate) (Sohocki et al. 1997; Yang et al. 2002). The active form of the enzyme is a dimer (Ishiguro et al. 1991) and is inferred to have a molecule of pyridoxal phosphate associated with each monomer. This reaction allows the synthesis of alanine from intermediates of glucose metabolism in a well-fed person. Under fasting conditions, alanine, derived from protein breakdown, can be converted to pyruvate and used to synthesize glucose via the gluconeogenic pathway in liver, or fully oxidized via the TCA cycle in other tissues.

Evidence1292
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12571226
xref: http://identifiers.org/pubmed/12732628
comment: After the MOCS2A dimer is loaded with two sulfur atoms, their sequential deposition on the precursor Z molecule, with ring cleavage, is catalyzed by the MOCS2B half of the MOCS2 tetramer (Leimkuhler et al, 2003; Wuebbens & Rajagopalan, 2002).

Evidence1293
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9990024
comment: Gephyrin, which stabilizes receptors on neuronal membranes, also catalyzes the transfer of a molybdenum ion onto the cofactor. The mechanism was elucidated in plants but, as the pathway is highly conserved, human gephyrin can complement missing plant proteins. Doubts remain about the actual molybdenum donor, probably molybdate, and whether a copper ion is possibly bound and removed (Stallmeyer et al, 1999).

Evidence1294
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11302742
comment: While the biosynthesis of the molybdenum cofactor for sulfite oxidase is finished after molybdenum ion insertion, human xanthine oxidase and aldehyde oxidase will only show activity with this cofactor when one of the oxygens bound to molybdenum is replaced with sulfur. The exchange is catalyzed by the MOCOS cysteine desulfurase (Ichida et al, 2001).

Evidence1295
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16261263
xref: http://identifiers.org/pubmed/19675644
comment: Molybdenum cofactor (MoCo) is needed by three enzymes in humans: sulfite oxidase, xanthine oxidase and aldehyde oxidase. The pathway of its synthesis is so conserved that plants and bacteria can readily use human enzymes. Bacteria, however, diverge after the first three steps from this path and their final MoCo differs from that of the eukaryotes. Plants and animals have also developed a refinement of their MoCo which is needed for the function of their xanthine and aldehyde oxidases. This means, in humans we find sulfurated instead of desulfurated molybdenum cofactor on these two enzymes (Schwarz 2005; Schwarz, Mendel, Ribbe 2009).

Evidence1226
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20385596
xref: http://identifiers.org/pubmed/15581572
xref: http://identifiers.org/pubmed/22556419
xref: http://identifiers.org/pubmed/12948489
xref: http://identifiers.org/pubmed/12427752
xref: http://identifiers.org/pubmed/16378245
comment: Enzymes that belong to the NUDT (Nudix) superfamily catalyze the hydrolysis of phosphodiester bonds in molecules including nucleoside triphosphates and diphosphates and nucleotide sugars. Family members are defined by the presence of an amino acid sequence motif shared with the E. coli MutT gene product, and are involved in diverse physiological processes (Mildvan et al. 2005; McLennan 2006). The hydrolysis of nucleoside di and triphosphates whose purine bases have been oxidized or deaminated may protect the cell from the mutational damage that would occur if modified deoxyribonucleotides were incorporated into DNA and from the aberrant protein synthesis that would occur if modified ribonucleotides were incorporated into mRNA (Iyama et al. 2010; Takagi et al. 2012). The hydrolysis of ADP ribose may prevent the aberrant spontaneous ADP ribosylation of cellular proteins that could occur were this molecule to accumulate to high levels in the cell (Perraud et al. 2003; Shen et al. 2003).

Evidence1225
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17052728
xref: http://identifiers.org/pubmed/18462755
xref: http://identifiers.org/pubmed/21389046
comment: Cytosolic NUDT5 dimer (ADP-ribose pyrophosphatase) catalyzes the hydrolysis of ADP-ribose to form AMP and D-ribose 5-phosphate. Each NUDT5 subunit is associated with three magnesium ions (Zha et al. 2006, 2008). NUDT5 also catalyzes the hydrolysis of 8-oxo-dGTP but with a strongly alkaline pH optimum (Ito et al. 2011) so the physiological relevance of this reaction is unclear and it is not annotated here.

Evidence1224
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11278832
xref: http://identifiers.org/pubmed/20081199
comment: Cytosolic ITPA dimer catalyzes the reaction of XTP and water to form XMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of XTP is thought to prevent its incorporation into mRNA, which would lead to aberrant protein synthesis (Lin et al. 2001; Abolhassani et al. 2010).

Evidence1223
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11278832
xref: http://identifiers.org/pubmed/20081199
comment: Cytosolic ITPA dimer catalyzes the reaction of dITP and water to form dIMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of dITP is thought to prevent its incorporation into DNA, which would be mutagenic (Lin et al. 2001; Abolhassani et al. 2010).

Evidence1229
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17222174
comment: Vitamin C (ascorbate) is an antioxidant and a cofactor in reactions catalyzed by Cu+-dependent monooxygenases and Fe++-dependent dioxygenases. Many mammals can synthesize ascorbate de novo; humans and other primates cannot due to an evolutionarily recent mutation in the gene catalyzing the last step of the biosynthetic pathway. Reactions annotated here mediate the uptake of ascorbate and its fully oxidized form, dehydroascorbate (DHA) by cells, and the reduction of DHA and monodehydroascorbate to regenerate ascorbate (Linster and Van Schaftingen 2007).

Evidence1228
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9228080
xref: http://identifiers.org/pubmed/10862609
comment: The uptake of extracellular dehydroascorbate into the cytosol is mediated by GLUT1 and GLUT3 associated with the plasma membrane (Rumsey et al. 1997, 2000). This process may play a significant role in ascorbate utilization in the central nervous system (Agus et al. 1997). The process is efficiently competitively inhibited by glucose, leading to the suggestion that inhibited dehydroascorbate uptake may contribute to the pathology of diabetes (Liang et al. 2001; Rumsey et al. 2000).

Evidence1227
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17266529
xref: http://identifiers.org/pubmed/8283301
xref: http://identifiers.org/pubmed/20494131
comment: Nucleotides and their derivatives are used for short-term energy storage (ATP, GTP), for intra- and extra-cellular signaling (cAMP; adenosine), as enzyme cofactors (NAD, FAD), and for the synthesis of DNA and RNA. Most dietary nucleotides are consumed by gut flora; the human body's own supply of these molecules is synthesized de novo. Additional metabolic pathways allow the interconversion of nucleotides, the salvage and reutilization of nucleotides released by degradation of DNA and RNA, and the catabolism of excess nucleotides (Rudolph 1994). These pathways are regulated to control the total size of the intracellular nucleotide pool, to balance the relative amounts of individual nucleotides, and to couple the synthesis of deoxyribonucleotides to the onset of DNA replication (S phase of the cell cycle). These pathways are also of major clinical interest as they are the means by which nucleotide analogues used as anti-viral and anti-tumor drugs are taken up by cells, activated, and catabolized (Weilin and Nordlund 2010). As well, differences in nuclotide metabolic pathways between humans and aplicomplexan parasites like Plasmodium have been exploited to design drugs to attack the latter (Hyde 2007). The movement of nucleotides and purine and pyrimidine bases across lipid bilayer membranes, mediated by SLC transporters, is annotated as part of the module "transmembrane transport of small molecules".

http://identifiers.org/pubmed/9438390
type: PublicationXref
id: 9438390
author: Webster, MK
author: Bardwell, WM
author: Meyer, AN
author: Donoghue, DJ
author: Robertson, SC
author: d'Avis, PY
db: Pubmed
title: Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I
source: Cell Growth Differ 9:71-8
year: 1998

Evidence1222
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11278832
xref: http://identifiers.org/pubmed/20081199
comment: Cytosolic ITPA dimer catalyzes the reaction of ITP and water to form IMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of ITP is thought to prevent its incorporation into mRNA, which would lead to aberrant protein synthesis (Lin et al. 2001; Abolhassani et al. 2010).

Evidence1221
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2222
xref: PublicationXref2220
xref: http://identifiers.org/pubmed/11008000
xref: http://identifiers.org/pubmed/177353
xref: http://identifiers.org/pubmed/5940
comment: An array of kinases catalyze the reversible phosphorylation of nucleotide monophosphates to form nucleotide diphosphates and triphosphates. Nucleoside monophosphate kinases catalyze the reversible phosphorylation of nucleoside and deoxynucleoside 5'-monophosphates to form the corresponding nucleoside 5'-diphosphates. Most appear to have restricted specificities for nucleoside monophosphates, and to use ATP preferentially (Van Rompay et al. 2000; Anderson 1973; Noda 1973). The total number of human enzymes that catalyze these reactions in vivo is not clear. In six cases, a well-defined biochemical activity has been associated with a purified protein, and these are annotated here. However, additional nucleoside monophosphate kinase-like human proteins have been identified in molecular cloning studies whose enzymatic activities are unknown, and several distinctive nucleoside monophosphate kinase activities detected in cell extracts, e.g., a GTP-requiring adenylate kinase activity (Wilson et al. 1976) and one or more guanylate kinase activities (Jamil et al. 1975) have not been unambiguously associated with specific human proteins. The nucleoside monophosphates against which each of the six well-characterized enzymes is active is shown in the table (Van Rompay et al. 2000). All six efficiently use ATP as a phosphate donor, but have some activity with other nucleoside triphosphates as well in vitro. The high concentrations of ATP relative to other nucleoside triphosphates in vivo makes it the likely major phosphate donor in these reactions under most conditions. All of these phosphorylation reactions are freely reversible in vitro when carried out with purified enzymes and substrates, having equilibrium constants near 1. In vivo, high ratios of ATP to ADP are likely to favor the forward direction of these reactions, i.e., the conversion of (d)NMP and ATP to (d)NDP and ADP. At the same time, the reversibility of the reactions and the overlapping substrate specificities of…

Evidence1220
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18635542
xref: http://identifiers.org/pubmed/9488696
xref: http://identifiers.org/pubmed/10799505
comment: Nucleoside diphosphate kinase NME4 associated with the inner mitochondrial membrane (Tokarska-Schlattner et al. 2008) catalyzes the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates with ADP to form the corresponding nucleoside 5'-diphosphates and ATP. The active form of the enzyme is a hexamer of NME4 polypeptides whose amino-terminal 33 residues, a mitochondrial translocation signal, have been removed (Milon et al. 2000). The substrate specificity of NME4 has not been examined in detail, but is inferred to be broad like that of the homologous NME1, 2, and 3 kinases (Schaertl et al. 1998).

Evidence1235
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4915004
comment: Riboflavin (vitamin B2, E101) is an essential component for the cofactors FAD (flavin-adenine dinucleotide) and FMN (flavin mononucleotide). Together with NAD+ and NADP+, FAD and FMN are important hydrogen carriers and take part in more than 100 redox reactions involved in energy metabolism. Riboflavin is present in many vegetables and meat and during digestion, various flavoproteins from food are degraded and riboflavin is resorbed. The major degradation and excretion product in humans is riboflavin (Rivlin 1970).

Evidence1234
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8001561
comment: Phosphatase action on flavin adenine dinucleotide (FAD) can reform flavin mononucleotide (FMN). The enzyme performing the reaction is nucleotide pyrophosphatase (ENPP1) and it exists as a homodimer on the plasma membrane.

Evidence1237
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11923312
xref: http://identifiers.org/pubmed/15581364
comment: The decarboxylation of phosphopantothenoylcysteine (PPC) to 4'-phosphopantetheine (PPANT) is carried out by phosphopantothenoylcysteine decarboxylase (PPCDC). PPCDC is cytosolic and exists as a homotrimer, binding one FMN cofactor per subunit. While a second isoform has been inferred from large-scale sequnceing studies, it lacks the protein's FMN-binding domain and would thus appear to be nonfunctional if it is expressed.

Evidence1236
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11923312
xref: http://identifiers.org/pubmed/12906824
comment: The conjugation of cysteine (Cys) and 4'- phosphopantothenate (PPanK) to form 4-phosphopantothenoylcysteine (PPC) , coupled to the conversion of ATP to AMP and pyrophosphate, is catalyzed by cytosolic phosphopantothenate-cysteine ligase (PPCS aka Phosphopantothenoylcysteine synthase or PPC synthase). Mammalian PPCS prefers ATP to CTP, unlike the E. coli ortholog (Daughtery et al. 2002; Manoj et al. 2003).

Evidence1239
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14514684
xref: http://identifiers.org/pubmed/11994049
comment: The kinase activity of CoA synthase (COASY) catalyzes the phosphorylation of dephospho-CoA to form Coenzyme A (CoA-SH). The enzyme is located in the mitochondrial outer membrane (Daugherty et al. 2002; Zhyvoloup et al. 2003).

Evidence1238
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14514684
xref: http://identifiers.org/pubmed/11994049
comment: The adenylyl transferase activity of bifunctional coenzyme A synthase (COASY) catalyzes the transfer of an adenylyl group from ATP to pantetheinephosphate (PPANT) to form dephospho-Coenzyme A (DP-CoA) (Daugherty et al. 2002). The enzyme is associated with the mitochondrial outer membrane (Zhyvoloup et al. 2003).

http://identifiers.org/pubmed/9188485
type: PublicationXref
id: 9188485
author: Folk, JE
author: Park, MH
author: Wolff, EC
db: Pubmed
title: Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase
source: J Biol Chem 272:15865-71
year: 1997

Evidence1231
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11342117
xref: http://identifiers.org/pubmed/11342111
xref: http://identifiers.org/pubmed/11435118
comment: Cytosolic thiamin pyrophosphokinase (TPK1) catalyzes the reaction of thiamin (THMN) and ATP to form thiamin diphosphate (ThDP aka thiamin pyrophosphate) and ADP. ThDP is an active cofactor for transketolase, pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, enzymes involved in glycolysis and energy production. The gene encoding the human enzyme has been cloned and its protein product has been shown to have TPK1 activity (Nosaka et al. 2001; Zhao et al. 2001). Its homodomeric structure and association with Mg2+ are inferred from properties of the homologous yeast enzyme (Baker et al. 2001).

Evidence1230
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14615284
xref: http://identifiers.org/pubmed/10391221
xref: http://identifiers.org/pubmed/16705148
xref: http://identifiers.org/pubmed/16790503
xref: http://identifiers.org/pubmed/16371350
xref: http://identifiers.org/pubmed/10391222
xref: http://identifiers.org/pubmed/10391223
comment: Two transport proteins, SLC19A2 (THTR1) and SLC19A3 (THTR2), associated with the plasma membrane, are each able to mediate the transport of extracellular thiamin into the cytosol. In the body, both transporters are widely distributed, and both are abundant in kidney and intestinal epithelia, consistent with their involvement in thiamin uptake under physiological conditions (Ashokkumar et al. 2006; Said et al. 2004; Subramanian et al. 2006 - J Biol Chem). The observation that mutations in SLC19A2 (THTR1) cause a progressive disorder that can be partially reversed by treatment with high doses of thiamin likewise suggests a role for this protein in thiamin uptake under normal conditions (Diaz et al. 1999; Fleming et al. 1999; Labay et al. 1999). Two features of this transport process remain incompletely understood, however. First, mutations in SLC19A3 cause a progressive disorder that is responsive to biotin treatment (Zhou et al. 2005), although studies of cultured cells indicate that the protein has no affinity for biotin (Subramanian et al. 2006 - Am J Physiol). Also, studies to date provide little information about the mechanism by which thiamin, once taken up by epithelial cells in the intestine and kidney, is released from these cells into the blood.

7,8-dihydro-7-hydroxy-8S-glutathionylbenzo[a]pyrene
type: SmallMoleculeReference
name: 7,8-dihydro-7-hydroxy-8S-glutathionylbenzo[a]pyrene [ChEBI:34479]
name: 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
xref: UnificationXref10137

Evidence1233
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16643857
comment: FMN can be phosphorylated and adenylated to produce the second cofactor from riboflavin origins, flavin adenine dinucleotide (FAD). The enzyme responsible , FMN adenylyltransferase (FLAD1 aka FAD synthase), is cytosolic and transfers a phosphate and an adenyl group from ATP to form FAD.

Evidence1232
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3060175
comment: Vitamin B1 (thiamin) is found naturally in certain foodstuffs such as green peas, spinach, liver, bananas, whole grains and legumes. Human diseases associated with thiamin deficiency include beriberi, due to a thiamin-deficient diet, TMRA, due to defects in the SLC19A2 transport protein, and Wernicke-Korsakoff Syndrome, associated with thiamin deficiency in alcoholism (Haas 1988). Thiamin is water-soluble so is not stored in the body. When pyrophosphorylated, thiamin is converted into the coenzyme thiamin pyrophosphate (ThPP, codecarboxylase) which plays an essential role in oxidative decarboxylation and group transfer reactions.

http://identifiers.org/pubmed/7356336
type: PublicationXref
id: 7356336
author: Logue, EA
author: Fall, RR
author: Hector, ML
author: Cochran, BC
db: Pubmed
title: Subcellular localization of 3-methylcrotonyl-coenzyme A carboxylase in bovine kidney
source: Arch Biochem Biophys 199:28-36
year: 1980

Evidence1249
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20174775
xref: http://identifiers.org/pubmed/19136951
comment: The probable lysosomal cobalamin transporter (LMBRD1) is the most likely candidate to transport cobalamin (Cbl) from inside the lysosome to the cytosol (Rutsch et al. 2009). From here, Cbl can either be used to synthesise the essential cofactors for methionine synthase in the cytosol or methylmalonyl-CoA mutase in the mitochondria or, it can transported out of the cell to tissues that require Cbl. Defects in LMBRD1 cause methylmalonic aciduria and homocystinuria type cblF (MMAHCF; MIM:277380), characterised biochemically by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MetCbl) (Rutsch et al. 2009, Gailus et al. 2010).

UniProt:Q55F21
type: ProteinReference
xref: UnificationXref5298
organism: Dictyostelium discoideum

Evidence1248
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10024608
comment: Animals cannot synthesize pyridoxal 5'-phosphate (PLP) which is a ligand in aminotransferases and other enzymes. PLP's accessible derivatives pyridoxine, pyridoxal, and pyridoxamine are traditionally called vitamins B6. They are taken up nutritionally from bacteria and plants, but also created from PLP in the body. The pathways used to recycle PLP from these three compounds can therefore be called vitamin B6 activation as well as PLP salvage. Because of the close similarity of the molecules, only two enzymes are needed for the task (McCormick & Chen, 1999).

Evidence1247
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15182361
comment: Pyridoxine-5'-phosphate oxidase (PNPO) is able to oxidize pyridoxine phosphate (PDXP) to pyridoxal 5'-phosphate (PXLP) (Kang et al. 2004).

Evidence1246
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15182361
comment: Pyridoxine-5'-phosphate oxidase (PNPO) is able to oxidize pyridoxamine phosphate (PXAP) to pyridoxal 5'-phosphate (PXLP) (Kang et al. 2004).

Evidence1245
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15249053
xref: http://identifiers.org/pubmed/10987144
comment: Pyridoxal kinase (PDXK) catalyzes the ATP-dependent phosphorylation of pyridoxine (PDX) to form pyridoxine phosphate (PDXP) (Lee et al. 2000, di Salvo et al. 2004).

Evidence1244
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15249053
xref: http://identifiers.org/pubmed/10987144
comment: Pyridoxal kinase (PDXK) catalyzes the ATP-dependent phosphorylation of pyridoxamine (PXA) to form pyridoxamine phosphate (PXAP) (Lee et al. 2000, di Salvo et al. 2004).

Evidence1243
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15249053
xref: http://identifiers.org/pubmed/10987144
comment: Pyridoxal kinase (PDXK) catalyzes the ATP-dependent phosphorylation of pyridoxal (PXL) to form pyridoxal 5'-phosphate (PXLP) (Lee et al. 2000, di Salvo et al. 2004).

Evidence1242
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2981478
xref: http://identifiers.org/pubmed/12815048
comment: Panthothenate (vitamin B5) is the precursor of coenzyme A (Robishaw and Neely 1985) and is the prosthetic group of acyl carrier protein (ACP) (Joshi et al. 2003). Its name is derived from the Greek pantothen meaning "from everywhere" and small quantities of pantothenic acid are found in nearly every foodstuff.

Evidence1241
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2981478
xref: http://identifiers.org/pubmed/11923312
xref: http://identifiers.org/pubmed/13032008
xref: http://identifiers.org/pubmed/11158296
xref: http://identifiers.org/pubmed/15893380
comment: Coenzyme A (CoA) is a ubiquitous cofactor that functions as an acyl group carrier in diverse processes including fatty acid metabolism and the TCA cycle (Lipmann 1953). It is synthesized from the vitamin pantothenate in a sequence of five reactions (Daugherty et al. 2002; Leonardi et al. 2005; Robishaw and Neely 1985). These reactions all occur in the cytosol or the mitochondrial intermembrane space (Leonardi et al. 2005). A recently described transport protein appears to mediate the uptake of Coenzyme A into the mitochondrial matrix (Prohl et al. 2001).

Evidence1240
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17242360
xref: http://identifiers.org/pubmed/11158296
comment: Graves disease carrier protein (SLC25A16), associated with the inner mitochondrial membrane, mediates the transport of cytosolic coenzyme A (CoA-SH) into the mitochondrial matrix. Evidence for this event is indirect. The protein has the sequence motifs expected for a transport protein, and yeast cells deficient in its homologue, Leu5p, fail to accumulate mitochondrial CoA-SH and can be rescued by expression of SLC25A16. At the same time, neither the yeast nor the human protein has been shown directly to function as a transporter (Prohl et al. 2001, Leonardi et al. 2007).

http://identifiers.org/pubmed/8541526
type: PublicationXref
id: 8541526
author: Park, JG
author: Hunter, S
author: Schreiber, AD
author: Indik, ZK
db: Pubmed
title: The molecular dissection of Fc gamma receptor mediated phagocytosis
source: Blood 86:4389-99
year: 1995

http://identifiers.org/pubmed/1371749
type: PublicationXref
id: 1371749
author: Saxty, BA
author: Groot, PH
author: Kmetz, PJ
author: Near, JC
author: Hughes, SA
author: Franklin, M
author: Wells, TN
author: Gloger, IS
author: Elshourbagy, NA
db: Pubmed
title: Cloning and expression of a human ATP-citrate lyase cDNA
source: Eur J Biochem 204:491-9
year: 1992

UnificationXref6409
type: UnificationXref
id: 191424
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191424

UnificationXref6407
type: UnificationXref
id: REACT_86628
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86628.9

UnificationXref6408
type: UnificationXref
id: CHEBI:17710
db: ChEBI

UnificationXref6405
type: UnificationXref
id: 3644416
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644416

UnificationXref6406
type: UnificationXref
id: 3644418
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644418

UnificationXref6403
type: UnificationXref
id: 3644414
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644414

UnificationXref6404
type: UnificationXref
id: 3644415
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644415

8,9-EpETrE [ChEBI:34490]
type: SmallMoleculeReference
name: 8,9-EpETrE
xref: UnificationXref7559

UnificationXref6401
type: UnificationXref
id: 191374
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191374

UnificationXref6402
type: UnificationXref
id: REACT_9666
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9666.2

http://identifiers.org/pubmed/8631325
type: PublicationXref
id: 8631325
author: Peng, HL
author: Chao, YC
author: Chang, HY
author: Duggleby, RG
author: Huang, JG
db: Pubmed
title: Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli.
source: Eur J Biochem 235:173-9
year: 1996

UnificationXref6400
type: UnificationXref
id: REACT_9741
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9741.2

Evidence1257
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/21511966
comment: Multidrug resistance-associated protein 1 (ABCC1, MRP1) can specifically mediate the ATP-dependant export of free cobalamin (Cbl aka vitamin B12) from small intestine cells to the portal vein (Shah et al. 2011).

Evidence1256
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16281286
xref: http://identifiers.org/pubmed/12438653
xref: http://identifiers.org/pubmed/2567699
xref: http://identifiers.org/pubmed/15523652
comment: Methylmalonyl-CoA mutase (MUT aka MCM) (Jansen et al. 1989) utilises adenosylcobalamin (AdoCbl) as a cofactor and transfers an adenosyl group from AdoCbl to methymalonyl-CoA to form succinyl-CoA, a precursor for the citric acid cycle. MUT has a homodimeric structure and is located in the mitochondrial matrix. Defects in MUT cause methylmalonic aciduria type mut (MMAM; MIM:251000), an often fatal disorder of organic acid metabolism (Worgan et al. 2006). Methylmalonic aciduria type A protein (MMAA) (Dobson et al. 2002) is thought to act as a chaperone to MUT and is suggested to play a dual role with regards to MUT protection and reactivation. Defects in MMAA cause methylmalonic aciduria type cblA (MMAA aka methylmalonic aciduria type A or vitamin B12-responsive methylmalonicaciduria of cblA complementation type; MIM:251100). Affected individuals accumulate methylmalonic acid in the blood and urine and are prone to potentially life threatening acidotic crises in infancy or early childhood (Dobson et al. 2002, Lerner-Ellis et al. 2004).

Evidence1259
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16134170
xref: http://identifiers.org/pubmed/9630604
xref: http://identifiers.org/pubmed/20153287
xref: http://identifiers.org/pubmed/22123817
comment: Biotin (Btn) acts as a coenzyme to 4 carboxylases which exist in their inactive apo forms. In the cytosol, these apo carboxylases are biotinylated to their active halo forms by the activity of biotin-protein ligase (HCLS) (Ingaramo & Beckett 2012, Hiratsuka et al. 1998, Bailey et al. 2010). Defects in HLCS causes holocarboxylase synthetase deficiency (HLCS deficiency aka biotin-responsive multiple carboxylase deficiency; MIM:253270). HLCS deficiency is an autosomal recessive disorder whereby deficient HLCS activity results in reduced activity of multiple carboxylases. Symptoms include metabolic acidosis, organic aciduria, lethargy, hypotonia, convulsions and dermatitis (Suzuki et al. 2005). Propionyl-CoA carboxylase is most likely functional as a dodecamer, composed of six Btn-containing alpha subunits (PCCA) and six beta subunits (PCCB). The exact order in which this complex is constructed is unknown.

Evidence1258
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/21312325
xref: http://identifiers.org/pubmed/20185591
xref: http://identifiers.org/pubmed/10448521
xref: http://identifiers.org/pubmed/19832808
comment: Vitamin B12 (cobalamin, Cbl) is a water-soluble vitamin with a key role in blood formation and normal functioning of the brain and nervous system. Cbl consists of a planar corrin ring coordinating with a cobalt atom through four nitrogen atoms. A 5,6-dimethylbenzamidizole base coordinates with the cobalt atom in the lower axial position while a number of different species can coordinate with the cobalt atom in the upper axial position. It is the cobalt-corrin ring complex that gives all Cbls a deep red colour. Only bacteria and archaea are able to synthesize Cbl thus humans need a dietary intake to prevent deficiency (Green 2010, Quadros 2010, Watkins & Rosenblatt 2011). A common semi-synthetic form of the vitamin, cyanocobalamin (CNCbl, where a cyanide group is in the upper axial position), is produced from bacterial hydroxocobalamin and used in many pharmaceuticals, supplements and as a food additive. In mammalian cells, Cbl or CNCbl is converted to two active coenzyme derivatives; methylcobalamin (MetCbl) and adenosylcobalamin (AdoCbl). MetCbl is required for activity of the cytoplasmic enzyme methionine synthase, which converts homocysteine to methionine. AdoCbl is required for activity of the mitochondrial enzyme methylmalonyl CoA mutase, which converts L-methylmalonyl-CoA to succinyl-CoA (Seetharam 1999). This pathway outlines the intake, transport and metabolism of Cbl and is assumed to be equally applicable to CNCbl.

Evidence1253
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8968737
comment: A methyl group from methylcobalamin (MeCbl) is transferred to homocysteine (HCYS), forming methionine (L-Met) (Leclerc et al. 1996). MTR is now in an inactive state as its cofactor state, B12r (cob(II)alamin), requires reduction to B12s (cob(I)alamin) to reactivate the enzyme. This is performed by methionine synthase reducatse (MTRR).

Evidence1252
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8968737
comment: Methionine synthase (MTR) catalyses the transfer of a methyl group from 5-methyltetrahydrofolate (MTHF) to homocysteine (HCYS) to then form methionine (L-Met). In the first step, MTR mediates the transfer of a methyl group from 5-methyltetrahydrofolate (MTHF) to B12s (bound to the enzyme MTR) to form the cofactor methylcobalamin (MeCbl), the form that activates MTR (Leclerc et al. 1996). Defects in MTR cause methylcobalamin deficiency type G (cblG; MIM:250940), an autosomal recessive inherited disease that causes mental retardation, macrocytic anemia, and homocystinuria. Mutations causing cblG include P1173L, Ile881, H920D, R585*, E1204* and A1204P (Leclerc et al. 1996, Gulati et al. 1996, Watkins et al. 2002).

Evidence1255
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12438653
xref: http://identifiers.org/pubmed/12514191
xref: http://identifiers.org/pubmed/18251506
comment: Mitochondrial cob(I)yrinic acid a,c-diamide adenosyltransferase (MMAB) is a dual purpose enzyme involved in the reduction and adenosylation of cobalamin. In the second step, MMAB transfers an adenosyl group from ATP to cob(I)alamin (B12s) to form adenosylcabalamin (AdoCbl) (Fan & Bobik 2008, Leal et al. 2003). Defects in MMAB cause methylmalonic aciduria type cblB (MMAB aka methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type; MIM:251110). Affected individuals have methylmalonic aciduria and metabolic ketoacidosis, despite a functional methylmalonyl-CoA mutase. In severe cases, newborns are lethargic, prone to vomiting and fail to thrive (Dobson et al. 2002).

Evidence1254
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12438653
xref: http://identifiers.org/pubmed/12514191
xref: http://identifiers.org/pubmed/18251506
comment: Mitochondrial cob(I)yrinic acid a,c-diamide adenosyltransferase (MMAB) is a dual purpose enzyme involved in the reduction and adenosylation of cobalamin. In the first step, MMAB reduces cob(II)alamin (B12r) to cob(I)alamin (B12s) (Fan & Bobik 2008, Leal et al. 2003). Defects in MMAB cause methylmalonic aciduria type cblB (MMAB aka methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type; MIM:251110). Affected individuals have methylmalonic aciduria and metabolic ketoacidosis, despite a functional methylmalonyl-CoA mutase. In severe cases, newborns are lethargic, prone to vomiting and fail to thrive (Dobson et al. 2002).

Evidence1251
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10484769
xref: http://identifiers.org/pubmed/17892308
xref: http://identifiers.org/pubmed/10444342
xref: http://identifiers.org/pubmed/17477549
xref: http://identifiers.org/pubmed/19243433
xref: http://identifiers.org/pubmed/12375236
comment: Methionine synthase reductase (MTRR) is involved in reducing B12r (cob(II)alamin) to B12s (cob(I)alamin), the cofactor form used by methionine synthase (MTR) to become functional. Regeneration of functional MTR requires reductive methylation via a reaction catalyzed by MTRR in which S-adenosylmethionine (SAM) is used as a methyl donor. MTRR requires 1 FMN and 1 FAD per subunit for activity (Wolthers et al. 2007). MTRR exists a stable complex with MTR, bound through their FMN-binding and C-terminal activation domains respectively (Wolthers & Scrutton 2007, Wolthers & Scrutton 2009). Defects in MTRR cause methylcobalamin deficiency type E (cblE; MIM:236270) (Wilson et al. 1999). Patients with cblE exhibit megaloblastic anemia and hyperhomocysteinemia. SAM is used as a methyl donor in many biological reactions and demethylation of methionine produces homocysteine. Remethylation is carried out by MTR but in cblE patients, MTR cannot be reduced by defective MTRR to form a functional enzyme thus homocysteine accumulates. Mutations in MTRR that cause cblE include Leu576del (Leclerc et al. 1998), S454L (Zavadakova et al. 2005) and the compound heterozygote G487R/M569Ifs*9 (Zavadakova et al. 2002). Wilson et al. showed that a 66A-G polymorphism, resulting in an Ile22Met (I22M) substitution, is associated with susceptibility to folate-sensitive neural tube defects (FS-NTD; MIM:601634) (Wilson et al. 1999b, Doolin et al. 2002). Serum deficiency of vitamin B12 increased the effect.

Evidence1250
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17892308
xref: http://identifiers.org/pubmed/17477549
xref: http://identifiers.org/pubmed/19243433
comment: Methionine synthase reductase (MTRR) is involved in reducing B12r (cob(II)alamin) to B12s (cob(I)alamin), the cofactor form used by methionine synthase (MTR) to become functional. MTRR requires 1 FMN and 1 FAD per subunit for activity (Wolthers et al. 2007). MTRR exists a stable complex with MTR, bound through their FMN-binding and C-terminal activation domains respectively (Wolthers & Scrutton 2007, Wolthers & Scrutton 2009).

AASS tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1838
component: Protein2059
xref: UnificationXref9354
cellular location: GO:0005759
comment: Reactome DB_ID: 3640555

PAK bound to Rac1 and Cdc42 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry153
component stoichiometry: Stoichiometry152
component: Active RAC1/CDC42
component: PhysicalEntity13
xref: UnificationXref526
cellular location: GO:0005829
comment: Reactome DB_ID: 3646545

PIP3:PDK1:active AKT (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry156
component stoichiometry: Stoichiometry155
component stoichiometry: Stoichiometry154
component: SmallMolecule17
component: Protein163
component: Protein149
xref: UnificationXref533
cellular location: GO:0005886
comment: Reactome DB_ID: 3646750

http://identifiers.org/pubmed/8645003
type: PublicationXref
id: 8645003
author: Hara, A
author: Bunai, Y
author: Ohya, I
author: Deyashiki, Y
author: Matsuura, K
db: Pubmed
title: Aldose reductase is a major reductase for isocaproaldehyde, a product of side-chain cleavage of cholesterol, in human and animal adrenal glands
source: Arch Biochem Biophys 328:265-71
year: 1996

AADAT dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1840
component: Protein2063
xref: UnificationXref9378
cellular location: GO:0005759
comment: Reactome DB_ID: 3640578

CDC42:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry149
component stoichiometry: Stoichiometry148
component: SmallMolecule1
component: Protein173
xref: UnificationXref517
cellular location: GO:0005829
comment: Reactome DB_ID: 3646014

ALDH7A1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1839
component: Protein2062
xref: UnificationXref9367
cellular location: GO:0005759
comment: Reactome DB_ID: 3640564

RAC1-GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry150
component stoichiometry: Stoichiometry151
component: Protein174
component: SmallMolecule1
xref: UnificationXref524
cellular location: GO:0005829
comment: Reactome DB_ID: 3646490

Active RAC1/CDC42
type: Complex
data source: Provenance1
member physical entity: CDC42:GTP (name copied from entity in Homo sapiens)
member physical entity: RAC1-GTP (name copied from entity in Homo sapiens)
xref: UnificationXref525
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3646538

HPD dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1848
component stoichiometry: Stoichiometry1849
component: Protein2073
component: SmallMolecule1000
xref: UnificationXref9449
cellular location: GO:0005829
comment: Reactome DB_ID: 3640735

TAT dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1847
component: Protein2072
xref: UnificationXref9437
cellular location: GO:0005829
comment: Reactome DB_ID: 3640728

HGD hexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1850
component stoichiometry: Stoichiometry1851
component: SmallMolecule225
component: Protein2074
xref: UnificationXref9457
cellular location: GO:0005829
comment: Reactome DB_ID: 3640742

PAH tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1844
component stoichiometry: Stoichiometry1843
component: SmallMolecule225
component: Protein2068
xref: UnificationXref9413
cellular location: GO:0005829
comment: Reactome DB_ID: 3640703

UnificationXref6410
type: UnificationXref
id: REACT_9551
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9551.2

UniProt:Q55F45
type: ProteinReference
xref: UnificationXref13134
organism: Dictyostelium discoideum

GCDH tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1841
component stoichiometry: Stoichiometry1842
component: Protein2067
component: SmallMolecule504
xref: UnificationXref9398
cellular location: GO:0005759
comment: Reactome DB_ID: 3640696

UnificationXref6411
type: UnificationXref
id: P34135
db: UniProt

QDPR dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1846
component: Protein2071
xref: UnificationXref9429
cellular location: GO:0005829
comment: Reactome DB_ID: 3640713

PCBD1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1845
component: Protein2070
xref: UnificationXref9424
cellular location: GO:0005829
comment: Reactome DB_ID: 3640720

UnificationXref6415
type: UnificationXref
id: 3644427
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644427

UnificationXref6414
type: UnificationXref
id: 3644426
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644426

UnificationXref6413
type: UnificationXref
id: P34136
db: UniProt

UnificationXref6412
type: UnificationXref
id: 3644422
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644422

UnificationXref6419
type: UnificationXref
id: CHEBI:17436
db: ChEBI

UnificationXref6418
type: UnificationXref
id: REACT_101728
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101728.9

UnificationXref6417
type: UnificationXref
id: 3644430
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644430

UnificationXref6416
type: UnificationXref
id: 3644428
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644428

http://identifiers.org/pubmed/19443651
type: PublicationXref
id: 19443651
author: Wang, Jianghai
author: Fukui, Lisa
author: Lee, Brian
author: Cai, Sheng
author: Chen, Yuan
author: Hu, Weidong
db: Pubmed
title: Conformational transition associated with E1-E2 interaction in small ubiquitin-like modifications
source: J. Biol. Chem. 284:20340-8
year: 2009

PAK homodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry147
component: PhysicalEntity13
xref: UnificationXref515
cellular location: GO:0005829
comment: Reactome DB_ID: 3646544

p-S-AKT:PDPK1:PIP3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry146
component stoichiometry: Stoichiometry145
component: PDPK1:PIP3 (name copied from entity in Homo sapiens)
component: p-S-AKT:PIP3 (name copied from entity in Homo sapiens)
xref: UnificationXref494
cellular location: GO:0005886
comment: Reactome DB_ID: 3644972

TORC2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry144
component stoichiometry: Stoichiometry141
component stoichiometry: Stoichiometry143
component stoichiometry: Stoichiometry142
component: Protein161
component: Protein162
component: PhysicalEntity12
component: Protein160
xref: UnificationXref491
cellular location: GO:0005829
comment: Reactome DB_ID: 3645034

p-S-AKT:PIP3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry140
component stoichiometry: Stoichiometry139
component: SmallMolecule17
component: Protein158
xref: UnificationXref483
cellular location: GO:0005886
comment: Reactome DB_ID: 3644971

AKT:PIP3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry137
component stoichiometry: Stoichiometry138
component: SmallMolecule17
component: Protein156
xref: UnificationXref478
cellular location: GO:0005886
comment: Reactome DB_ID: 3645028

PDPK1:PIP3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry136
component stoichiometry: Stoichiometry135
component: SmallMolecule17
component: Protein149
xref: UnificationXref471
cellular location: GO:0005886
comment: Reactome DB_ID: 3644967

branched-chain alpha-ketoacid dehydrogenase E1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1822
component stoichiometry: Stoichiometry1820
component stoichiometry: Stoichiometry1821
component: Protein2046
component: SmallMolecule785
component: Protein2045
xref: UnificationXref9227
cellular location: GO:0005759
comment: Reactome DB_ID: 3640419

PDK1:PIP2,PIP3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry126
component stoichiometry: Stoichiometry125
component: SmallMolecule21
component: Protein149
xref: UnificationXref453
cellular location: GO:0005886
comment: Reactome DB_ID: 3645280

branched-chain alpha-ketoacid dehydrogenase complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1819
component stoichiometry: Stoichiometry1823
component stoichiometry: Stoichiometry1818
component: Complex581
component: branched-chain alpha-ketoacid dehydrogenase E1 complex (name copied from entity in Homo sapiens)
component: Protein2044
xref: UnificationXref9228
cellular location: GO:0005759
comment: Reactome DB_ID: 3640431

PKC-theta (open): DAG (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry127
component stoichiometry: Stoichiometry128
component: SmallMolecule16
component: Protein151
xref: UnificationXref458
cellular location: GO:0005886
comment: Reactome DB_ID: 3645300

p-Y90-PKC-theta:DAG (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry130
component stoichiometry: Stoichiometry129
component: SmallMolecule16
component: Protein152
xref: UnificationXref462
cellular location: GO:0005886
comment: Reactome DB_ID: 3645285

Active PKC theta bound to DAG (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry132
component stoichiometry: Stoichiometry133
component: SmallMolecule16
component: Protein153
xref: UnificationXref464
cellular location: GO:0005886
comment: Reactome DB_ID: 3645290

UniProt:Q8T295
type: ProteinReference
xref: UnificationXref2144
organism: Dictyostelium discoideum

FTCD octamer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1837
component stoichiometry: Stoichiometry1836
component: SmallMolecule329
component: Protein2058
xref: UnificationXref9339
cellular location: GO:0005829
comment: Reactome DB_ID: 3640543

urocanate hydratase (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1834
component stoichiometry: Stoichiometry1833
component: SmallMolecule376
component: Protein2056
xref: UnificationXref9324
cellular location: GO:0005829
comment: Reactome DB_ID: 3640530

HIBADH tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1832
component: Protein2053
xref: UnificationXref9301
cellular location: GO:0005759
comment: Reactome DB_ID: 3640511

UniProt:Q55ER0
type: ProteinReference
xref: UnificationXref12941
organism: Dictyostelium discoideum

ACAD8 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1830
component stoichiometry: Stoichiometry1831
component: Protein2051
component: SmallMolecule504
xref: UnificationXref9283
cellular location: GO:0005759
comment: Reactome DB_ID: 3640498

UniProt:Q55ER5
type: ProteinReference
xref: UnificationXref4124
organism: Dictyostelium discoideum

HSD17B10 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1829
component: Protein2050
xref: UnificationXref9271
cellular location: GO:0005759
comment: Reactome DB_ID: 3640484

ACADSB tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1828
component stoichiometry: Stoichiometry1827
component: SmallMolecule504
component: Protein2049
xref: UnificationXref9260
cellular location: GO:0005759
comment: Reactome DB_ID: 3640477

UnificationXref6420
type: UnificationXref
id: 191296
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191296

AUH hexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1826
component: Protein2048
xref: UnificationXref9252
cellular location: GO:0005759
comment: Reactome DB_ID: 3640470

UnificationXref6421
type: UnificationXref
id: REACT_9694
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9694.2

IVD tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1824
component stoichiometry: Stoichiometry1825
component: Protein2047
component: SmallMolecule504
xref: UnificationXref9236
cellular location: GO:0005759
comment: Reactome DB_ID: 3640451

UnificationXref6422
type: UnificationXref
id: Q86AG7
db: UniProt

UnificationXref6424
type: UnificationXref
id: 3644441
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644441

UnificationXref6423
type: UnificationXref
id: 3644440
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644440

http://identifiers.org/pubmed/16738315
type: PublicationXref
id: 16738315
author: Lee, Hsiang-Ying
author: Gill, Grace
author: Catic, Andre
author: Di Bacco, A
author: Ouyang, Jian
author: Ploegh, Hidde
db: Pubmed
title: The SUMO-specific protease SENP5 is required for cell division
source: Mol. Cell. Biol. 26:4489-98
year: 2006

UnificationXref6426
type: UnificationXref
id: REACT_82902
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82902.9

UnificationXref6425
type: UnificationXref
id: 3644443
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644443

UnificationXref6428
type: UnificationXref
id: 191403
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191403

UnificationXref6427
type: UnificationXref
id: CHEBI:15899
db: ChEBI

http://identifiers.org/pubmed/19957260
type: PublicationXref
id: 19957260
author: Lambert, DM
author: Ferrer, JL
author: Bauvois, C
author: Wouters, J
author: Borel, F
author: Labar, G
db: Pubmed
title: Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling
source: Chembiochem 11:218-27
year: 2010

UnificationXref6429
type: UnificationXref
id: REACT_9758
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9758.2

Activated PLC gamma1 bound to PIP2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry122
component stoichiometry: Stoichiometry121
component: Protein145
component: SmallMolecule12
xref: UnificationXref415
cellular location: GO:0005886
comment: Reactome DB_ID: 3645303

VAMP2:STX4:SNAP23 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry119
component stoichiometry: Stoichiometry118
component stoichiometry: Stoichiometry120
component: Protein38
component: Protein132
component: Protein37
xref: UnificationXref381
cellular location: GO:0005886
comment: Reactome DB_ID: 3649491

6,7-dihydrobiopterin [ChEBI:20680]
type: SmallMoleculeReference
name: 6,7-dihydrobiopterin
xref: UnificationXref9419

PTEN:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry123
component stoichiometry: Stoichiometry124
component: Protein147
component: SmallMolecule20
xref: UnificationXref445
cellular location: GO:0005829
comment: Reactome DB_ID: 3645088

RAC1:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry112
component stoichiometry: Stoichiometry113
component: Protein117
component: SmallMolecule11
xref: UnificationXref358
cellular location: GO:0005886
comment: Reactome DB_ID: 3645461

TC10:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry111
component stoichiometry: Stoichiometry110
component: SmallMolecule11
component: Protein116
xref: UnificationXref342
cellular location: GO:0005886
comment: Reactome DB_ID: 3650996

GLUT4:TUG (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry117
component stoichiometry: Stoichiometry116
component: Protein131
component: Protein124
xref: UnificationXref377
cellular location: GO:0030659
comment: Reactome DB_ID: 3649488

http://identifiers.org/pubmed/17266540
type: PublicationXref
id: 17266540
author: Wellendorph, P
author: Jensen, AA
author: Brauner-Osborne, Hans
db: Pubmed
title: Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors
source: Curr Drug Targets 8:169-84
year: 2007

STX4:STXBP3 (MUNC18C) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry114
component stoichiometry: Stoichiometry115
component: Protein38
component: Protein123
xref: UnificationXref361
cellular location: GO:0005886
comment: Reactome DB_ID: 3649490

Translocon (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry245
component stoichiometry: Stoichiometry246
component stoichiometry: Stoichiometry244
component: Protein295
component: Protein294
component: Protein296
xref: UnificationXref939
cellular location: GO:0030670
comment: Reactome DB_ID: 3649264

TAP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry251
component stoichiometry: Stoichiometry250
component: Protein297
component: Protein302
xref: UnificationXref958
cellular location: GO:0030670
comment: Reactome DB_ID: 3649288

ARD:Fe++ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1868
component stoichiometry: Stoichiometry1869
component: SmallMolecule225
component: Protein2092
xref: UnificationXref9632
cellular location: GO:0005829
comment: Reactome DB_ID: 3649312

Evidence1200
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9718352
comment: Cytosolic dihydropyrimidinase tetramer catalyzes the reaction of 5,6-dihydrothymine and water to yield 3-ureidoisobutyrate (Hamajima et al. 1998).

Particulate Ag:DC receptors (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry243
component stoichiometry: Stoichiometry242
component: PhysicalEntity26
component: Protein288
xref: UnificationXref914
cellular location: GO:0005886
comment: Reactome DB_ID: 3649291

DIO1 homodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1877
component: Protein2095
xref: UnificationXref9699
cellular location: GO:0005886
comment: Reactome DB_ID: 3645505

Rap1-GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry259
component stoichiometry: Stoichiometry258
component: Protein355
component: SmallMolecule11
xref: UnificationXref1116
cellular location: GO:0005886
comment: Reactome DB_ID: 3645919

Ensembl:DDB0233625
type: ProteinReference
xref: UnificationXref5067
organism: Dictyostelium discoideum

TH:Fe2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1870
component stoichiometry: Stoichiometry1871
component: SmallMolecule225
component: Protein2093
xref: UnificationXref9647
cellular location: GO:0005829
comment: Reactome DB_ID: 3645515

AGE adducts:Peptide
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry260
component stoichiometry: Stoichiometry261
component: SmallMolecule96
component: SmallMolecule93
xref: UnificationXref1194
xref: UnificationXref1193
cellular location: GO:0005576
comment: Reactome DB_ID: 879479

DAO dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1882
component: D-amino-acid oxidase:FAD complex (name copied from entity in Homo sapiens)
xref: UnificationXref9729
cellular location: GO:0005782
comment: Reactome DB_ID: 3646554

Rap1 cAMP-GEFs:cAMP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry255
component stoichiometry: Stoichiometry254
component: Protein352
component: SmallMolecule90
xref: UnificationXref1108
cellular location: GO:0005829
comment: Reactome DB_ID: 3646849

Ensembl:DDB0233626
type: ProteinReference
xref: UnificationXref5071
organism: Dictyostelium discoideum

TPH:Fe++ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1878
component stoichiometry: Stoichiometry1879
component: Protein2096
component: SmallMolecule225
xref: UnificationXref9712
cellular location: GO:0005829
comment: Reactome DB_ID: 3645521

Rap1-GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry257
component stoichiometry: Stoichiometry256
component: SmallMolecule91
component: Protein355
xref: UnificationXref1115
cellular location: GO:0005886
comment: Reactome DB_ID: 3645920

Ensembl:DDB0233623
type: ProteinReference
xref: UnificationXref5074
organism: Dictyostelium discoideum

UniProt:Q55EU6
type: ProteinReference
xref: UnificationXref1337
organism: Dictyostelium discoideum

AGXT dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1883
component: Protein2100
xref: UnificationXref9738
cellular location: GO:0005782
comment: Reactome DB_ID: 3646535

Evidence1205
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/5484814
xref: http://identifiers.org/pubmed/6182143
comment: Mitochondrial adenylate kinase 2 (AK2) catalyzes the reaction of two molecules of ADP to form AMP and ATP (Hamade et al. 1982). Localization of AK2 specifically to the mitochondrial intermembrane space is inferred from studies of the homologous rat enzyme (Criss 1970).

UnificationXref6432
type: UnificationXref
id: REACT_9725
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9725.2

UniProt:Q55EU7
type: ProteinReference
xref: UnificationXref6449
organism: Dictyostelium discoideum

D-amino-acid oxidase:FAD complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1880
component stoichiometry: Stoichiometry1881
component: Protein2099
component: SmallMolecule533
xref: UnificationXref9728
cellular location: GO:0005782
comment: Reactome DB_ID: 3646553

Evidence1206
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8663313
xref: http://identifiers.org/pubmed/177353
xref: http://identifiers.org/pubmed/6248551
xref: http://identifiers.org/pubmed/211390
comment: Cytosolic guanylate kinase 1 (GUK1) catalyzes the reversible reactions of GMP and dGMP with ATP to form GDP and dGDP respectively and ADP. While native gel electrophoretic studies of whole cell extracts suggested the existence of multiple human enzymes with guanylate kinase activity (Jamil et al. 1975), only one has been purified and biochemically characterized (Agarwal et al. 1978; Brady et al. 1996). The enzyme is of clinical importance as it is a target of antitumor drugs and antiviral drugs such as acyclovir (Miller and Miller 1980).

UnificationXref6433
type: UnificationXref
id: Q54YQ9
db: UniProt

MAT I homotetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1887
component: MAT I/III (Mg, K cofactors) (name copied from entity in Homo sapiens)
xref: UnificationXref9753
cellular location: GO:0005829
comment: Reactome DB_ID: 3644104

Evidence1207
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8663313
xref: http://identifiers.org/pubmed/177353
xref: http://identifiers.org/pubmed/6248551
xref: http://identifiers.org/pubmed/211390
comment: Cytosolic guanylate kinase 1 (GUK1) catalyzes the reversible reactions of GDP and dGDP with ADP to form GMP and dGMP respectively and ATP. While native gel electrophoretic studies of whole cell extracts suggested the existence of multiple human enzymes with guanylate kinase activity (Jamil et al. 1975), only one has been purified and biochemically characterized (Agarwal et al. 1978; Brady et al. 1996). The enzyme is of clinical importance as it is a target of antitumor drugs and antiviral drugs such as acyclovir (Miller and Miller 1980).

UnificationXref6430
type: UnificationXref
id: CHEBI:16584
db: ChEBI

MAT multimers
type: Complex
data source: Provenance1
member physical entity: MAT I homotetramer (name copied from entity in Homo sapiens)
member physical entity: MAT II heterotetramer (name copied from entity in Homo sapiens)
member physical entity: MAT II homodimer (name copied from entity in Homo sapiens)
xref: UnificationXref9758
cellular location: GO:0005829
comment: Reactome DB_ID: 3644111
comment: Converted from EntitySet in Reactome

Evidence1208
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11912132
xref: http://identifiers.org/pubmed/40615
comment: Cytosolic UMP-CMP kinase (CMPK1) catalyzes the reversible reaction of CMP, dCMP, or UMP and ATP to form CDP, dCDP, or UDP and ADP (Liou et al. 2002; Scott and Wright 1979).

UnificationXref6431
type: UnificationXref
id: 191362
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191362

Evidence1201
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10989446
xref: http://identifiers.org/pubmed/15385443
comment: Cytosolic UPB1 (beta-ureidopropionase) catalyzes the reaction of 3-ureidoisobutyrate and H2O to form (R)-3-aminoisobutyrate, CO2, and NH3 (Tamaki et al. 2000; van Kuilenburg et al. 2004).

MAT I/III (Mg, K cofactors) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1884
component stoichiometry: Stoichiometry1885
component stoichiometry: Stoichiometry1886
component: SmallMolecule383
component: Protein2102
component: SmallMolecule20
xref: UnificationXref9752
cellular location: GO:0005829
comment: Reactome DB_ID: 3644103

Evidence1202
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2178
xref: http://identifiers.org/pubmed/3090932
xref: http://identifiers.org/pubmed/10989446
comment: In parallel sequences of three reactions each, thymine is converted to beta-aminoisobutyrate and uracil is converted to beta-alanine. Both of these molecules are excreted in human urine and appear to be normal end products of pyrimidine catabolism (Griffith 1986; Webster et al. 2001). Mitochondrial AGXT2, however, can also catalyze the transamination of both molecules with pyruvate, yielding 2-oxoacids that can be metabolized further by reactions of branched-chain amino acid and short-chain fatty acid catabolism (Tamaki et al. 2000). The importance of these reactions in normal human pyrimidine catabolism has not been well worked out.

Evidence1203
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16098809
comment: The events of human pyrimidine metabolism are conveniently, if somewhat arbitrarily, grouped into four pathways: de novo synthesis of the pyrimidine ring and its conversion to uridine 5'-monophosphate (UMP), the biosynthesis of other pyrimidine ribo- and deoxyribonucleotides, pyrimidine salvage reactions, and pyrimidine catabolism (Loffler et al. 2005). De novo synthesis of the pyrimidine ring and its conversion to UMP. The pyrimidine base orotate is synthesized from glutamine, bicarbonate, and aspartate. Orotate reacts with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) and is then decarboxylated to form the pyrimidine nucleotide UMP. Pyrimidine biosynthesis [interconversion]. Pyrimidine ribo- and deoxyribonucleotide di- and triphosphates are synthesized, both from UMP and from pyrimidine ribonucleotide monophosphates generated in salvage reactions. Pyrimidine salvage reactions. Pyrimidine nucleosides and free bases generated by DNA and RNA breakdown are converted to nucleotide monophosphates. Pyrimidine catabolism. The pyrimidine bases thymine and uracil are degraded to beta-aminoisobutyrate and beta-alanine, respectively, which are excreted from the body.

Evidence1204
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/5484814
xref: http://identifiers.org/pubmed/6182143
comment: Mitochondrial adenylate kinase 2 (AK2) catalyzes the reaction of AMP and ATP to form two molecules of ADP (Hamade et al. 1982). Localization of AK2 specifically to the mitochondrial intermembrane space is inferred from studies of the homologous rat enzyme (Criss 1970).

http://identifiers.org/pubmed/15153069
type: PublicationXref
id: 15153069
author: Lake, S
author: Climent, I
author: Swiezewska, E
author: Forsgren, M
author: Attersand, A
author: Dallner, G
author: Grünler, J
db: Pubmed
title: Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ
source: Biochem J 382:519-26
year: 2004

UnificationXref6439
type: UnificationXref
id: 191324
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191324

UnificationXref6438
type: UnificationXref
id: CHEBI:16057
db: ChEBI

UnificationXref6437
type: UnificationXref
id: REACT_101324
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101324.9

Signal transduction by L1
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction104
evidence: Evidence180
xref: UnificationXref1663
xref: UnificationXref1662
pathway order: PathwayStep174
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

Evidence1209
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11912132
xref: http://identifiers.org/pubmed/40615
comment: Cytosolic UMP-CMP kinase (CMPK1) catalyzes the reversible reaction of CDP, dCDP, or UDP and ADP to form CMP, dCMP, or UMP and ATP (Liou et al. 2002; Scott and Wright 1979).

UnificationXref6436
type: UnificationXref
id: 3644465
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644465

http://identifiers.org/pubmed/11681785
type: PublicationXref
id: 11681785
author: Hruz, PW
author: Mueckler, MM
db: Pubmed
title: Structural analysis of the GLUT1 facilitative glucose transporter (review).
source: Mol Membr Biol 18:183-93
year: 2001

UnificationXref6435
type: UnificationXref
id: 3644463
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644463

Sema3A PAK dependent Axon repulsion
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction86
evidence: Evidence174
xref: UnificationXref1648
xref: UnificationXref1647
pathway order: PathwayStep132
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref6434
type: UnificationXref
id: 3644462
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644462

TAP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry240
component stoichiometry: Stoichiometry241
component: Protein277
component: Protein272
xref: UnificationXref848
cellular location: GO:0005789
comment: Reactome DB_ID: 3648972

ChEBI:28540 5beta-cholestane-3alpha,7alpha,26-triol
type: SmallMoleculeReference
name: 5beta-cholestane-3alpha,7alpha,26-triol
xref: UnificationXref6695

26S proteasome (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry230
component stoichiometry: Stoichiometry218
component stoichiometry: Stoichiometry209
component stoichiometry: Stoichiometry201
component stoichiometry: Stoichiometry210
component stoichiometry: Stoichiometry194
component stoichiometry: Stoichiometry224
component stoichiometry: Stoichiometry198
component stoichiometry: Stoichiometry216
component stoichiometry: Stoichiometry231
component stoichiometry: Stoichiometry195
component stoichiometry: Stoichiometry236
component stoichiometry: Stoichiometry223
component stoichiometry: Stoichiometry228
component stoichiometry: Stoichiometry233
component stoichiometry: Stoichiometry234
component stoichiometry: Stoichiometry235
component stoichiometry: Stoichiometry207
component stoichiometry: Stoichiometry196
component stoichiometry: Stoichiometry199
component stoichiometry: Stoichiometry208
component stoichiometry: Stoichiometry215
component stoichiometry: Stoichiometry229
component stoichiometry: Stoichiometry197
component stoichiometry: Stoichiometry227
component stoichiometry: Stoichiometry205
component stoichiometry: Stoichiometry211
component stoichiometry: Stoichiometry200
component stoichiometry: Stoichiometry214
component stoichiometry: Stoichiometry217
component stoichiometry: Stoichiometry203
component stoichiometry: Stoichiometry221
component stoichiometry: Stoichiometry219
component stoichiometry: Stoichiometry232
component stoichiometry: Stoichiometry220
component stoichiometry: Stoichiometry212
component stoichiometry: Stoichiometry202
component stoichiometry: Stoichiometry222
component stoichiometry: Stoichiometry226
component stoichiometry: Stoichiometry204
component stoichiometry: Stoichiometry225
component stoichiometry: Stoichiometry193
component stoichiometry: Stoichiometry206
component stoichiometry: Stoichiometry213
component: Protein250
component: Protein245
component: PhysicalEntity21
component: Protein264
component: Protein228
component: Protein232
component: Protein252
component: Protein235
component: Protein253
component: Protein233
component: Protein240
component: Protein259
component: Protein254
component: PhysicalEntity19
component: Protein261
component: Protein234
component: Protein237
component: PhysicalEntity20
component: Protein236
component: Protein244
component: Protein225
component: Protein255
component: Protein256
component: Protein263
component: Protein239
component: Protein251
component: Protein246
component: Protein231
component: Protein243
component: Protein247
component: Protein257
component: Protein238
component: Protein258
component: Protein227

Ensembl:DDB0218071
type: ProteinReference
xref: UnificationXref5042
organism: Dictyostelium discoideum

E3:K48-polyubiquitinated substrate (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry191
component stoichiometry: Stoichiometry192
component: PhysicalEntity16
component: PhysicalEntity15
xref: UnificationXref668
cellular location: GO:0005829
comment: Reactome DB_ID: 3648979

Ensembl:DDB0187092
type: ProteinReference
xref: UnificationXref5048
organism: Dictyostelium discoideum

Ub:substrate (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry186
component stoichiometry: Stoichiometry185
component: Protein217
component: PhysicalEntity14
xref: UnificationXref663
cellular location: GO:0005829
comment: Reactome DB_ID: 3648946

Ensembl:DDB0238632
type: ProteinReference
xref: UnificationXref5046
organism: Dictyostelium discoideum

Evidence1210
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18469
comment: Cytosolic deoxythymidylate kinase (DTYMK) catalyzes the reversible reaction of either dUMP or TMP with ATP to form dUDP or TDP. The active form of the enzyme is a homodimer (Lee and Cheng 1977).

Evidence1211
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18469
comment: Cytosolic deoxythymidylate kinase (DTYMK) catalyzes the reversible reaction of either dUDP or TDP with ADP to form dUMP or TMP. The active form of the enzyme is a homodimer (Lee and Cheng 1977).

p21 RAS:GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry174
component stoichiometry: Stoichiometry173
component: SmallMolecule2
component: Protein199
xref: UnificationXref588
cellular location: GO:0005886
comment: Reactome DB_ID: 3642785

p21 RAS:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry175
component stoichiometry: Stoichiometry176
component: Protein199
component: SmallMolecule1
xref: UnificationXref589
cellular location: GO:0005886
comment: Reactome DB_ID: 3642784

TDO2 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1857
component stoichiometry: Stoichiometry1856
component: Protein2079
component: SmallMolecule147
xref: UnificationXref9502
cellular location: GO:0005829
comment: Reactome DB_ID: 3640763

PDPK1:PIP2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry179
component stoichiometry: Stoichiometry180
component: SmallMolecule12
component: Protein149
xref: UnificationXref625
cellular location: GO:0005886
comment: Reactome DB_ID: 3650949

ALDH4A1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1855
component: Protein2078
xref: UnificationXref9492
cellular location: GO:0005759
comment: Reactome DB_ID: 3640408

E1 bound ubiquitin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry181
component stoichiometry: Stoichiometry182
component: Protein217
component: Protein210
xref: UnificationXref652
cellular location: GO:0005829
comment: Reactome DB_ID: 3648999

FAH dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1854
component: Protein2076
xref: UnificationXref9476
cellular location: GO:0005829
comment: Reactome DB_ID: 3640756

Ubiquitin:E2 conjugating enzymes (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry184
component stoichiometry: Stoichiometry183
component: Protein223
component: Protein217
xref: UnificationXref658
cellular location: GO:0005829
comment: Reactome DB_ID: 3648944

GSTZ1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1852
component stoichiometry: Stoichiometry1853
component: Protein2075
component: SmallMolecule695
xref: UnificationXref9465
cellular location: GO:0005829
comment: Reactome DB_ID: 3640749

E3:Ub:substrate (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry187
component stoichiometry: Stoichiometry188
component: PhysicalEntity15
component: Ub:substrate (name copied from entity in Homo sapiens)
xref: UnificationXref665
cellular location: GO:0005829
comment: Reactome DB_ID: 3648947

ACMSD dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1862
component: Protein2084
xref: UnificationXref9546
cellular location: GO:0005829
comment: Reactome DB_ID: 3640791

Evidence1218
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/13211603
xref: http://identifiers.org/pubmed/12972261
xref: http://identifiers.org/pubmed/11277919
xref: http://identifiers.org/pubmed/1851158
xref: PublicationXref2216
xref: http://identifiers.org/pubmed/9488696
comment: Cytosolic nucleoside diphosphate kinases catalyze the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates with ADP to form the corresponding nucleoside 5'-diphosphates and ATP. These kinases are ubiquitously expressed enzymes with broad substrate specificities (Berg and Joklik 1954; Parks and Agarwal 1973). Three human cytosolic nucleoside diphosphate kinase proteins, NME1, 2, and 3, have been characterized biochemically (Gilles et al. 1991; Schaertl et al. 1998; Erent et al. 2001; Chen et al. 2003). All are catalytically active as hexamers: homohexamers of NME1, 2, and 3 have been described, as have heterohexamers containing all possible combinations of NME1 and 2 (Gilles et al. 1991; Erent et al. 2001). While the high ratio of ATP to ADP concentrations in the cytosol normally favors the conversion of (d)NDP and ATP to (d)NTP and ADP, the reversibility of the reactions and the overlapping substrate specificities of the enzymes suggest that this group of reverse reactions can buffer the intracellular nucleotide pool and regulate the relative concentrations of individual nucleoside di- and tri-phosphates in the pool.

UnificationXref6441
type: UnificationXref
id: Q9NH02
db: UniProt

HAAO (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1861
component stoichiometry: Stoichiometry1860
component: SmallMolecule225
component: Protein2083
xref: UnificationXref9538
cellular location: GO:0005829
comment: Reactome DB_ID: 3640784

Evidence1219
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18635542
xref: http://identifiers.org/pubmed/9488696
xref: http://identifiers.org/pubmed/10799505
comment: Nucleoside diphosphate kinase NME4 associated with the inner mitochondrial membrane (Tokarska-Schlattner et al. 2008) catalyzes the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates with ATP to form the corresponding nucleoside 5'-triphosphates and ADP. The active form of the enzyme is a hexamer of NME4 polypeptides whose amino-terminal 33 residues, a mitochondrial translocation signal, have been removed (Milon et al. 2000). The substrate specificity of NME4 has not been examined in detail but is inferred to be broad like that of the homologous NME1, 2, and 3 kinases (Schaertl et al. 1998).

UnificationXref6442
type: UnificationXref
id: 3644447
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644447

KYNU dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1859
component: Protein2082
xref: UnificationXref9530
cellular location: GO:0005829
comment: Reactome DB_ID: 3640777

Evidence1216
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: In this reaction, 1 molecule of 'Thioredoxin' is translocated from cytosol to nucleoplasm. This movement of the molecule occurs through the 'nuclear pore'.

UnificationXref6443
type: UnificationXref
id: 3644448
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644448

CCBL2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1858
component: Protein2080
xref: UnificationXref9515
cellular location: GO:0005829
comment: Reactome DB_ID: 3648431

Evidence1217
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/13211603
xref: http://identifiers.org/pubmed/12972261
xref: http://identifiers.org/pubmed/11277919
xref: http://identifiers.org/pubmed/1851158
xref: PublicationXref2216
xref: http://identifiers.org/pubmed/9488696
comment: Cytosolic nucleoside diphosphate kinases catalyze the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates with ATP to form the corresponding nucleoside 5'-triphosphates and ADP. These kinases are ubiquitously expressed enzymes with broad substrate specificities (Berg and Joklik 1954; Parks and Agarwal 1973). Three human cytosolic nucleoside diphosphate kinase proteins, NME1, 2, and 3, have been characterized biochemically (Gilles et al. 1991; Schaertl et al. 1998; Erent et al. 2001; Chen et al. 2003). All are catalytically active as hexamers: homohexamers of NME1, 2, and 3 have been described, as have heterohexamers containing all possible combinations of NME1 and 2 (Gilles et al. 1991; Erent et al. 2001). While cytosolic nucleoside diphosphate kinases can efficiently use several nucleotide triphosphates as a phosphate donor, the high concentrations of ATP relative to other nucleoside triphosphates in vivo makes it the likely major phosphate donor in these reactions and only reactions with ATP as the phosphate donor are annotated. All of these phosphorylation reactions are freely reversible in vitro (Parks and Agarwal 1973; Schaertl et al. 1998), but the high ratio of ATP to ADP concentrations in the cytosol should favor the conversion of (d)NDP and ATP to (d)NTP and ADP.

UnificationXref6444
type: UnificationXref
id: 3644450
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644450

Evidence1214
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/947404
comment: Cytosolic glutathione reductase catalyzes the reaction of glutathione (oxidized) and NADPH + H+ to form two molecules of glutathione (reduced) and NADP+ (Loos et al. 1976).

http://identifiers.org/pubmed/18555844
type: PublicationXref
id: 18555844
author: Buehrer, B
author: Madan, AK
author: Fain, JN
author: Bahouth, SW
author: Tichansky, DS
db: Pubmed
title: Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue
source: Metabolism 57:1005-15
year: 2008

Evidence1215
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: In this reaction, 1 molecule of 'thioredoxin, oxidized' is translocated from nucleoplasm to cytosol. This movement of the molecule occurs through the 'nuclear pore'.

E1:Mg++ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1866
component stoichiometry: Stoichiometry1867
component: Protein2091
component: SmallMolecule20
xref: UnificationXref9624
cellular location: GO:0005829
comment: Reactome DB_ID: 3649319

Evidence1212
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16179339
xref: http://identifiers.org/pubmed/16820675
comment: Cytosolic CTP synthase 1 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005). The active form of the enzyme is a tetramer (Kursala et al. 2006). Both CTPS and a second human gene product, CPTS2, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.

http://identifiers.org/pubmed/15276077
type: PublicationXref
id: 15276077
author: Chimienti, F
author: Seve, M
author: Favier, A
author: Coquerel, Y
author: Pennequin, A
author: Devergnas, S
author: Naud, N
author: Chantegrel, J
db: Pubmed
title: Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study
source: Biochem Pharmacol 68:699-709
year: 2004

APIP:Zn++ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1864
component stoichiometry: Stoichiometry1863
component: SmallMolecule108
component: Protein2090
xref: UnificationXref9616
cellular location: GO:0005829
comment: Reactome DB_ID: 3649326

Evidence1213
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10899599
xref: http://identifiers.org/pubmed/16179339
comment: Cytosolic CTP synthase 2 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005; van Kuilenberg et al. 2000). Unpublished X-ray crystallographic data suggest that the enzyme is a tetramer (PDB 3IHL). Both CTPS2 and a second human gene product, CPTS, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.

UnificationXref6440
type: UnificationXref
id: REACT_9855
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9855.2

http://identifiers.org/pubmed/17266529
type: PublicationXref
id: 17266529
author: Hyde, JE
db: Pubmed
title: Targeting purine and pyrimidine metabolism in human apicomplexan parasites
source: Curr Drug Targets 8:31-47
year: 2007

UnificationXref6449
type: UnificationXref
id: Q55EU7
db: UniProt

UnificationXref6446
type: UnificationXref
id: CHEBI:17211
db: ChEBI

UnificationXref6445
type: UnificationXref
id: REACT_86357
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86357.9

UnificationXref6448
type: UnificationXref
id: REACT_9593
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9593.2

UnificationXref6447
type: UnificationXref
id: 191409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191409

PP2A (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry162
component stoichiometry: Stoichiometry161
component stoichiometry: Stoichiometry160
component: Protein180
component: Protein186
component: Protein188
xref: UnificationXref549
cellular location: GO:0005829
comment: Reactome DB_ID: 3646497

5,6-EpETrE [ChEBI:34450]
type: SmallMoleculeReference
name: 5,6-EpETrE
xref: UnificationXref7554

PDK1:AKT:PIP3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry158
component stoichiometry: Stoichiometry159
component stoichiometry: Stoichiometry157
component: SmallMolecule17
component: Protein156
component: Protein149
xref: UnificationXref534
cellular location: GO:0005886
comment: Reactome DB_ID: 3644983

Activated PKC beta (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry170
component stoichiometry: Stoichiometry168
component stoichiometry: Stoichiometry169
component stoichiometry: Stoichiometry167
component: SmallMolecule23
component: SmallMolecule24
component: Protein192
component: SmallMolecule13
xref: UnificationXref571
cellular location: GO:0005886
comment: Reactome DB_ID: 3643320

Ensembl:DDB0233624
type: ProteinReference
xref: UnificationXref5078
organism: Dictyostelium discoideum

Active Calmodulin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry165
component stoichiometry: Stoichiometry164
component: Protein113
component: SmallMolecule22
xref: UnificationXref559
cellular location: GO:0005829
comment: Reactome DB_ID: 3642201

Ensembl:DDB0233622
type: ProteinReference
xref: UnificationXref5076
organism: Dictyostelium discoideum

p-RasGRP1,3:DAG (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry171
component stoichiometry: Stoichiometry172
component: Protein196
component: SmallMolecule13
xref: UnificationXref583
cellular location: GO:0005886
comment: Reactome DB_ID: 3649225

UnificationXref6451
type: UnificationXref
id: Q9NH03
db: UniProt

UnificationXref6450
type: UnificationXref
id: 3644391
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644391

UnificationXref6455
type: UnificationXref
id: 3644400
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644400

UnificationXref6454
type: UnificationXref
id: 3644399
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644399

UnificationXref6453
type: UnificationXref
id: Q54XP1
db: UniProt

UnificationXref6452
type: UnificationXref
id: 3644395
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644395

CD28 dependent PI3K/Akt signaling
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction37
pathway component: BiochemicalReaction35
pathway component: BiochemicalReaction33
pathway component: BiochemicalReaction34
pathway component: BiochemicalReaction36
evidence: Evidence52
xref: UnificationXref501
xref: UnificationXref502
pathway order: PathwayStep47
pathway order: PathwayStep44
pathway order: PathwayStep46
pathway order: PathwayStep48
pathway order: PathwayStep45
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

ESCRT-III (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry53
component stoichiometry: Stoichiometry52
component stoichiometry: Stoichiometry50
component stoichiometry: Stoichiometry51
component stoichiometry: Stoichiometry49
component: Protein62
component: Protein59
component: Protein67
component: Protein63
component: Protein58
xref: UnificationXref192
cellular location: GO:0005829
comment: Reactome DB_ID: 3648567

Ensembl:DDB0168507
type: ProteinReference
xref: UnificationXref5999
organism: Dictyostelium discoideum

Ensembl:DDB0187976
type: ProteinReference
xref: UnificationXref5988
organism: Dictyostelium discoideum

Ensembl:DDB0183825
type: ProteinReference
xref: UnificationXref5985
organism: Dictyostelium discoideum

Ensembl:DDB0235400
type: ProteinReference
xref: UnificationXref5979
organism: Dictyostelium discoideum

Vamp7:SNAP23:Syn4 Plasma membrane vesicle docking and fusion complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry40
component stoichiometry: Stoichiometry41
component stoichiometry: Stoichiometry39
component: Protein47
component: Protein38
component: Protein37
xref: UnificationXref147
cellular location: GO:0005886
comment: Reactome DB_ID: 3646037

ESCRT-II/Cargo Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry45
component stoichiometry: Stoichiometry48
component: Ubiquinated and PIP3 Endosmal Membrane Bound Cargo (name copied from entity in Homo sapiens)
component: ESCRT-II (name copied from entity in Homo sapiens)
xref: UnificationXref175
cellular location: GO:0010008
comment: Reactome DB_ID: 3648612

Arf1-GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry34
component stoichiometry: Stoichiometry35
component: SmallMolecule2
component: Protein36
xref: UnificationXref112
cellular location: GO:0005829
comment: Reactome DB_ID: 3645189

Vamp2:SNAP23:Syn4 Secretory granule docking and fusion complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry36
component stoichiometry: Stoichiometry38
component stoichiometry: Stoichiometry37
component: Protein38
component: Protein41
component: Protein37
xref: UnificationXref140
cellular location: GO:0005886
comment: Reactome DB_ID: 3646052

Coatomer:Arf1-GTP Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry30
component stoichiometry: Stoichiometry29
component: Arf1-GTP (name copied from entity in Homo sapiens)
component: Coatomer (name copied from entity in Homo sapiens)
xref: UnificationXref89
cellular location: GO:0000139
comment: Reactome DB_ID: 3645138

Coatomer:Arf1-GTP:GAP Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry33
component stoichiometry: Stoichiometry32
component stoichiometry: Stoichiometry31
component: Arf1-GTP (name copied from entity in Homo sapiens)
component: Coatomer (name copied from entity in Homo sapiens)
component: Protein35
xref: UnificationXref94
cellular location: GO:0000139
comment: Reactome DB_ID: 3645181

Arf1-GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry21
component stoichiometry: Stoichiometry20
component: Protein23
component: SmallMolecule1
xref: UnificationXref63
cellular location: GO:0000139
comment: Reactome DB_ID: 3645108

Coatomer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry24
component stoichiometry: Stoichiometry27
component stoichiometry: Stoichiometry22
component stoichiometry: Stoichiometry28
component stoichiometry: Stoichiometry26
component stoichiometry: Stoichiometry23
component stoichiometry: Stoichiometry25
component: Protein29
component: Protein30
component: Protein32
component: Protein33
component: Protein31
component: Protein34
component: Protein28
xref: UnificationXref88
cellular location: GO:0005829
comment: Reactome DB_ID: 3645137

UnificationXref6458
type: UnificationXref
id: Q54BK1
db: UniProt

UnificationXref6459
type: UnificationXref
id: 3644406
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644406

UnificationXref6456
type: UnificationXref
id: 3644401
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644401

UnificationXref6457
type: UnificationXref
id: 3644402
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644402

ESCRT-II (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry44
component stoichiometry: Stoichiometry43
component stoichiometry: Stoichiometry42
component: Protein50
component: Protein51
component: Protein49
xref: UnificationXref161
cellular location: GO:0005829
comment: Reactome DB_ID: 3648611

Ubiquinated and PIP3 Endosmal Membrane Bound Cargo (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry46
component stoichiometry: Stoichiometry47
component: SmallMolecule4
component: Protein52
xref: UnificationXref174
cellular location: GO:0010008
comment: Reactome DB_ID: 3648574

UnificationXref6460
type: UnificationXref
id: 3644407
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644407

UnificationXref6462
type: UnificationXref
id: 3644409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644409

UnificationXref6461
type: UnificationXref
id: 3644408
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644408

UnificationXref6464
type: UnificationXref
id: REACT_96115
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96115.9

UnificationXref6463
type: UnificationXref
id: 3644413
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644413

UnificationXref6466
type: UnificationXref
id: 191385
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191385

UnificationXref6465
type: UnificationXref
id: CHEBI:17407
db: ChEBI

ChEBI:28533 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestanoyl-CoA
type: SmallMoleculeReference
name: 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestanoyl-CoA
xref: UnificationXref6640

http://identifiers.org/pubmed/15538381
type: PublicationXref
id: 15538381
author: Lu, M
author: Gherzi, R
author: Leuenberger, SA
author: Hemmings, BA
author: Stoecklin, G
author: Hess, D
author: Mallaun, M
author: Schmidlin, M
author: Moroni, C
author: Gross, B
db: Pubmed
title: The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B
source: EMBO J 23:4760-9
year: 2004

UnificationXref6467
type: UnificationXref
id: REACT_9889
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9889.2

UnificationXref6468
type: UnificationXref
id: 3644411
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644411

UnificationXref6469
type: UnificationXref
id: REACT_86410
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86410.9

UnificationXref6477
type: UnificationXref
id: REACT_97704
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97704.9

UnificationXref6476
type: UnificationXref
id: 3644458
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644458

UnificationXref6475
type: UnificationXref
id: 3644455
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644455

UnificationXref6474
type: UnificationXref
id: 3644454
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644454

UnificationXref6473
type: UnificationXref
id: Q54DR1
db: UniProt

UnificationXref6472
type: UnificationXref
id: REACT_9707
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9707.1

UnificationXref6471
type: UnificationXref
id: 191265
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191265

UnificationXref6470
type: UnificationXref
id: CHEBI:15442
db: ChEBI

RALA:GTP:MYO1C:Exocyst (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry109
component stoichiometry: Stoichiometry108
component: Exocyst Complex (name copied from entity in Homo sapiens)
component: RALA:GTP:MYO1C:Calmodulin:F-actin (name copied from entity in Homo sapiens)
xref: UnificationXref331
cellular location: GO:0030659
comment: Reactome DB_ID: 3650990

RALA:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry105
component stoichiometry: Stoichiometry106
component: SmallMolecule9
component: PhysicalEntity11
xref: UnificationXref329
cellular location: GO:0030659
comment: Reactome DB_ID: 3650981

MYO1C:CALM1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry101
component stoichiometry: Stoichiometry102
component: Protein113
component: Protein110
xref: UnificationXref327
cellular location: GO:0005829
comment: Reactome DB_ID: 3650982

Ensembl:DDB0238329
type: ProteinReference
xref: UnificationXref5592
organism: Dictyostelium discoideum

RAB8A/10/13/14:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry83
component stoichiometry: Stoichiometry84
component: SmallMolecule9
component: Protein97
xref: UnificationXref281
cellular location: GO:0030659
comment: Reactome DB_ID: 3649442

Ensembl:DDB0231226
type: ProteinReference
xref: UnificationXref5456
organism: Dictyostelium discoideum

RGC1:RGC2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry86
component stoichiometry: Stoichiometry85
component: Protein98
component: Protein99
xref: UnificationXref292
cellular location: GO:0005829
comment: Reactome DB_ID: 3649553

p-S237-TBC1D1:14-3-3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry80
component stoichiometry: Stoichiometry79
component: Protein88
component: YWHAE dimer (name copied from entity in Homo sapiens)
xref: UnificationXref271
cellular location: GO:0005829
comment: Reactome DB_ID: 3649507

RAB8A/10/13/14:GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry82
component stoichiometry: Stoichiometry81
component: Protein97
component: SmallMolecule10
xref: UnificationXref280
cellular location: GO:0030659
comment: Reactome DB_ID: 3649443

Exocyst Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry100
component stoichiometry: Stoichiometry99
component stoichiometry: Stoichiometry98
component stoichiometry: Stoichiometry95
component stoichiometry: Stoichiometry97
component stoichiometry: Stoichiometry96
component stoichiometry: Stoichiometry94
component stoichiometry: Stoichiometry93
component: Protein109
component: Protein106
component: Protein107
component: PhysicalEntity10
component: Protein103
component: Protein105
component: Protein108
component: Protein104
xref: UnificationXref319
cellular location: GO:0005886
comment: Reactome DB_ID: 3650989

RALA:GTP:MYO1C:Calmodulin:F-actin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry104
component stoichiometry: Stoichiometry107
component stoichiometry: Stoichiometry103
component: MYO1C:CALM1 (name copied from entity in Homo sapiens)
component: PhysicalEntity9
component: RALA:GTP (name copied from entity in Homo sapiens)
xref: UnificationXref330
cellular location: GO:0030659
comment: Reactome DB_ID: 3650983

RGC1:p-486,696-T715-RGC2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry88
component stoichiometry: Stoichiometry89
component: Protein100
component: Protein99
xref: UnificationXref294
cellular location: GO:0005829
comment: Reactome DB_ID: 3649558

p-S1652-MYO5A:F-actin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry91
component stoichiometry: Stoichiometry92
component: Protein102
component: PhysicalEntity9
xref: UnificationXref301
cellular location: GO:0005829
comment: Reactome DB_ID: 3649503

UnificationXref6478
type: UnificationXref
id: CHEBI:15440
db: ChEBI

http://identifiers.org/pubmed/11907280
type: PublicationXref
id: 11907280
author: Hagting, A
author: Pines, J
author: Jackman, M
author: Kubota, Y
author: Den Elzen, N
db: Pubmed
title: Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm
source: Mol Biol Cell 13:1030-45
year: 2002

UnificationXref6479
type: UnificationXref
id: 191269
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191269

UnificationXref6486
type: UnificationXref
id: DDB0234143
db: Ensembl

UnificationXref6485
type: UnificationXref
id: REACT_9761
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9761.1

http://identifiers.org/pubmed/10448521
type: PublicationXref
id: 10448521
author: Seetharam, B
db: Pubmed
title: Receptor-mediated endocytosis of cobalamin (vitamin B12)
source: Annu. Rev. Nutr. 19:173-95
year: 1999

UnificationXref6488
type: UnificationXref
id: 29386
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29386

UnificationXref6487
type: UnificationXref
id: 3644384
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644384

Ensembl:DDB0203614
type: ProteinReference
xref: UnificationXref5712
organism: Dictyostelium discoideum

UnificationXref6482
type: UnificationXref
id: REACT_30428
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30428.10

UnificationXref6481
type: UnificationXref
id: 3644457
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644457

UnificationXref6484
type: UnificationXref
id: 191309
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191309

UniProt:Q55EX5
type: ProteinReference
xref: UnificationXref10503
organism: Dictyostelium discoideum

UnificationXref6483
type: UnificationXref
id: CHEBI:15441
db: ChEBI

Ensembl:DDB0218876
type: ProteinReference
xref: UnificationXref5818
organism: Dictyostelium discoideum

UniProt:Q8T1V4
type: ProteinReference
xref: UnificationXref10774
organism: Dictyostelium discoideum

http://identifiers.org/pubmed/9335335
type: PublicationXref
id: 9335335
author: Bell, SP
author: Aparicio, OM
author: Weinstein, DM
db: Pubmed
title: Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase.
source: Cell 91:59-69
year: 1997

Ensembl:DDB0266617
type: ProteinReference
xref: UnificationXref5816
organism: Dictyostelium discoideum

UnificationXref6480
type: UnificationXref
id: REACT_9771
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9771.2

Ensembl:DDB0187902
type: ProteinReference
xref: UnificationXref5732
organism: Dictyostelium discoideum

Ensembl:DDB0202935
type: ProteinReference
xref: UnificationXref5883
organism: Dictyostelium discoideum

AMPK gamma:AMP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry76
component stoichiometry: Stoichiometry77
component: SmallMolecule8
component: Protein93
xref: UnificationXref267
cellular location: GO:0005829
comment: Reactome DB_ID: 3649509

UniProt:Q8T277
type: ProteinReference
xref: UnificationXref262
organism: Dictyostelium discoideum

AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry78
component stoichiometry: Stoichiometry75
component stoichiometry: Stoichiometry74
component: Protein89
component: AMPK gamma:AMP (name copied from entity in Homo sapiens)
component: Protein90
xref: UnificationXref268
cellular location: GO:0005829
comment: Reactome DB_ID: 3649510

Porphyrin
type: SmallMoleculeReference
name: Porphyrin [ChEBI:8337]
xref: UnificationXref2672

ESCRT-III/Cargo Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry54
component stoichiometry: Stoichiometry55
component: Ubiquinated and PIP3 Endosmal Membrane Bound Cargo (name copied from entity in Homo sapiens)
component: ESCRT-III (name copied from entity in Homo sapiens)
xref: UnificationXref193
cellular location: GO:0010008
comment: Reactome DB_ID: 3648575

UnificationXref2200
type: UnificationXref
id: 3641149
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641149

Ubiquinated and PIP3 Endosmal Membrane Bound Cargo (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry57
component stoichiometry: Stoichiometry56
component: Protein68
component: SmallMolecule7
xref: UnificationXref211
cellular location: GO:0030666
comment: Reactome DB_ID: 3648582

UnificationXref2201
type: UnificationXref
id: DDB0233353
db: Ensembl

Vps/Vta1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry61
component stoichiometry: Stoichiometry58
component stoichiometry: Stoichiometry60
component stoichiometry: Stoichiometry59
component: Protein75
component: Protein77
component: Protein76
component: Protein74
xref: UnificationXref219
cellular location: GO:0005829
comment: Reactome DB_ID: 3648596

UnificationXref2202
type: UnificationXref
id: 3641076
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641076

AS160:IRAP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry62
component stoichiometry: Stoichiometry63
component: Protein81
component: Protein78
xref: UnificationXref232
cellular location: GO:0030659
comment: Reactome DB_ID: 3649456

UnificationXref2203
type: UnificationXref
id: 3641134
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641134

Phospho AS160:IRAP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry67
component stoichiometry: Stoichiometry66
component: Protein82
component: Protein78
xref: UnificationXref236
cellular location: GO:0030659
comment: Reactome DB_ID: 3649464

UnificationXref2204
type: UnificationXref
id: 3640999
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640999

YWHAE dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry68
component: Protein85
xref: UnificationXref244
cellular location: GO:0005829
comment: Reactome DB_ID: 3645443

UnificationXref2205
type: UnificationXref
id: 3641000
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641000

Phospho AS160:14-3-3:IRAP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry72
component stoichiometry: Stoichiometry73
component: Phospho AS160:14-3-3 (name copied from entity in Homo sapiens)
component: Protein78
xref: UnificationXref248
cellular location: GO:0030659
comment: Reactome DB_ID: 3649475

UnificationXref2206
type: UnificationXref
id: 3641001
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641001

Phospho AS160:14-3-3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry70
component stoichiometry: Stoichiometry71
component: Protein82
component: YWHAE dimer (name copied from entity in Homo sapiens)
xref: UnificationXref247
cellular location: GO:0030659
comment: Reactome DB_ID: 3649474

UnificationXref2207
type: UnificationXref
id: 77507
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77507

YWHAE dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry69
component: Protein86
xref: UnificationXref246
cellular location: GO:0030659
comment: Reactome DB_ID: 3649473

http://identifiers.org/pubmed/16738331
type: PublicationXref
id: 16738331
author: Itahana, Yoko
author: Yeh, Edward T H
author: Zhang, Yanping
db: Pubmed
title: Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2
source: Mol. Cell. Biol. 26:4675-89
year: 2006

UnificationXref2208
type: UnificationXref
id: REACT_3578
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3578.1

UnificationXref2209
type: UnificationXref
id: 3641002
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641002

UnificationXref6489
type: UnificationXref
id: REACT_4227
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4227.1

UnificationXref4246
type: UnificationXref
id: 3643379
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643379

UnificationXref4245
type: UnificationXref
id: REACT_80457
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80457.9

SequenceSite2680
type: SequenceSite
position status: EQUAL
sequence position: 515

UnificationXref2109
type: UnificationXref
id: 71994
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71994

UnificationXref4248
type: UnificationXref
id: 3643383
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643383

UnificationXref2108
type: UnificationXref
id: 3641257
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641257

UnificationXref4247
type: UnificationXref
id: DDB0304834
db: Ensembl

http://identifiers.org/pubmed/7564244
type: PublicationXref
id: 7564244
author: Mooyer, P
author: Wanders, RJ
db: Pubmed
title: D-2-hydroxyglutaric acidaemia: identification of a new enzyme, D-2-hydroxyglutarate dehydrogenase, localized in mitochondria
source: J Inherit Metab Dis 18:194-6
year: 1995

SequenceSite2683
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref4249
type: UnificationXref
id: 3643384
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643384

SequenceSite2684
type: SequenceSite
position status: EQUAL
sequence position: 483

SequenceSite2681
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2682
type: SequenceSite
position status: EQUAL
sequence position: 258

UnificationXref2103
type: UnificationXref
id: Q55BS1
db: UniProt

SequenceSite2687
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2102
type: UnificationXref
id: 3641279
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641279

SequenceSite2688
type: SequenceSite
position status: EQUAL
sequence position: 337

UnificationXref2101
type: UnificationXref
id: 3641278
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641278

SequenceSite2685
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2100
type: UnificationXref
id: DDB0233707
db: Ensembl

SequenceSite2686
type: SequenceSite
position status: EQUAL
sequence position: 228

UnificationXref2107
type: UnificationXref
id: DDB0233702
db: Ensembl

UnificationXref2106
type: UnificationXref
id: 3641265
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641265

FDX1L (reduced) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1995
component stoichiometry: Stoichiometry1994
component: SmallMolecule1122
component: Protein2190
xref: UnificationXref10271
cellular location: GO:0005759
comment: Reactome DB_ID: 3649405

UnificationXref2105
type: UnificationXref
id: Q86A79
db: UniProt

SequenceSite2689
type: SequenceSite
position status: EQUAL
sequence position: 1

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2004
component stoichiometry: Stoichiometry2000
component stoichiometry: Stoichiometry2003
component stoichiometry: Stoichiometry2002
component stoichiometry: Stoichiometry2001
component: SmallMolecule1124
component: Protein2188
component: Protein2185
component: NFS1:pyridoxal phosphate (name copied from entity in Homo sapiens)
component: Protein2186
xref: UnificationXref10280
cellular location: GO:0005759
comment: Reactome DB_ID: 3649406

UnificationXref2104
type: UnificationXref
id: 3641261
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641261

UniProt:Q55E92
type: ProteinReference
xref: UnificationXref2497
organism: Dictyostelium discoideum

CIAPIN1:4Fe-4S:2Fe-2S oxidized (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2007
component stoichiometry: Stoichiometry2008
component stoichiometry: Stoichiometry2006
component: SmallMolecule1135
component: Protein2191
component: SmallMolecule1134
xref: UnificationXref10343
cellular location: GO:0005829
comment: Reactome DB_ID: 3651340

UnificationXref8272
type: UnificationXref
id: REACT_124901
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124901.1

NDOR1:CIAPIN1 oxidized (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2009
component stoichiometry: Stoichiometry2013
component: NDOR1:FAD:FMN (name copied from entity in Homo sapiens)
component: CIAPIN1:4Fe-4S:2Fe-2S oxidized (name copied from entity in Homo sapiens)
xref: UnificationXref10347
cellular location: GO:0005829
comment: Reactome DB_ID: 3651346

UnificationXref8273
type: UnificationXref
id: 3650800
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3650800

NDOR1:CIAPIN1 reduced (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2018
component stoichiometry: Stoichiometry2014
component: NDOR1:FAD:FMN (name copied from entity in Homo sapiens)
component: CIAPIN1:4Fe-4S:2Fe-2S reduced (name copied from entity in Homo sapiens)
xref: UnificationXref10351
cellular location: GO:0005829
comment: Reactome DB_ID: 3651348

UnificationXref8270
type: UnificationXref
id: CHEBI:16830
db: ChEBI

NDOR1:FAD:FMN (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2012
component stoichiometry: Stoichiometry2010
component stoichiometry: Stoichiometry2011
component: SmallMolecule556
component: Protein2192
component: SmallMolecule846
xref: UnificationXref10346
cellular location: GO:0005829
comment: Reactome DB_ID: 3651345

UnificationXref8271
type: UnificationXref
id: 2161177
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161177

NUBP1:4Fe-4S (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2019
component stoichiometry: Stoichiometry2020
component: Protein2193
component: SmallMolecule1134
xref: UnificationXref10356
cellular location: GO:0005829
comment: Reactome DB_ID: 3651358

CIAPIN1:4Fe-4S:2Fe-2S reduced (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2016
component stoichiometry: Stoichiometry2015
component stoichiometry: Stoichiometry2017
component: SmallMolecule1136
component: Protein2191
component: SmallMolecule1134
xref: UnificationXref10350
cellular location: GO:0005829
comment: Reactome DB_ID: 3651347

NARFL:CIAO1:FAM96B:MMS19 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2033
component stoichiometry: Stoichiometry2028
component stoichiometry: Stoichiometry2032
component stoichiometry: Stoichiometry2031
component: Protein2202
component: NARFL:4Fe-4S (name copied from entity in Homo sapiens)
component: Protein2201
component: Protein2199
xref: UnificationXref10380
cellular location: GO:0005829
comment: Reactome DB_ID: 3651380

NUBP2:4Fe-4S:NUBP1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2025
component stoichiometry: Stoichiometry2026
component stoichiometry: Stoichiometry2027
component: Protein2194
component: NUBP1:4Fe-4S (name copied from entity in Homo sapiens)
component: SmallMolecule1134
xref: UnificationXref10362
cellular location: GO:0005829
comment: Reactome DB_ID: 3651359

UnificationXref8278
type: UnificationXref
id: 3642161
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642161

UnificationXref8279
type: UnificationXref
id: DDB0187721
db: Ensembl

UnificationXref4240
type: UnificationXref
id: 3643870
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643870

UnificationXref8276
type: UnificationXref
id: REACT_126149
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126149.5

UnificationXref4241
type: UnificationXref
id: REACT_153975
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153975.3

UnificationXref8277
type: UnificationXref
id: Q55C82
db: UniProt

UnificationXref4242
type: UnificationXref
id: 3652008
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652008

UnificationXref8274
type: UnificationXref
id: 3650801
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3650801

UnificationXref4243
type: UnificationXref
id: REACT_155860
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155860.3

http://identifiers.org/pubmed/10501970
type: PublicationXref
id: 10501970
author: Francomano, CA
author: Munnich, A
author: King, LM
author: Wilkin, DJ
author: Clarke, CF
author: Ho, N
author: Jonassen, T
author: Vajo, Z
db: Pubmed
title: Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging
source: Mamm Genome 10:1000-4
year: 1999

UnificationXref8275
type: UnificationXref
id: 3650803
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3650803

UnificationXref4244
type: UnificationXref
id: 3651834
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651834

UnificationXref4237
type: UnificationXref
id: 3643868
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643868

UnificationXref4236
type: UnificationXref
id: 3643867
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643867

UnificationXref4235
type: UnificationXref
id: REACT_99549
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99549.9

UnificationXref4234
type: UnificationXref
id: 3651833
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651833

SequenceSite2670
type: SequenceSite
position status: EQUAL
sequence position: 681

SequenceSite2671
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/10970868
type: PublicationXref
id: 10970868
author: Bell, SP
author: Klemm, RD
author: Lee, DG
author: Makhov, AM
db: Pubmed
title: Regulation of origin recognition complex conformation and ATPase activity: differential effects of single-stranded and double-stranded DNA binding.
source: EMBO J 19:4774-82
year: 2000

UnificationXref4239
type: UnificationXref
id: 3643869
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643869

SequenceSite2672
type: SequenceSite
position status: EQUAL
sequence position: 843

UnificationXref4238
type: UnificationXref
id: 3643841
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643841

SequenceSite2673
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/15519848
type: PublicationXref
id: 15519848
author: Reissmann, S
author: Meyer, AS
author: Frydman, J
author: Spiess, C
db: Pubmed
title: Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets
source: Trends Cell Biol 14:598-604
year: 2004

SequenceSite2674
type: SequenceSite
position status: EQUAL
sequence position: 842

SequenceSite2675
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2676
type: SequenceSite
position status: EQUAL
sequence position: 842

SequenceSite2677
type: SequenceSite
position status: EQUAL
sequence position: 1

D-Fructose 2,6-bisphosphate [ChEBI:28602]
type: SmallMoleculeReference
name: D-Fructose 2,6-bisphosphate
xref: UnificationXref5209

Holoprotein Containing 4Fe-4S Cluster
type: Complex
data source: Provenance1
member physical entity: holo-POLD1 (name copied from entity in Homo sapiens)
member physical entity: holo-XPD (name copied from entity in Homo sapiens)
member physical entity: holo-BRIP1 (holo-FANCJ) (name copied from entity in Homo sapiens)
xref: UnificationXref10384
cellular location: GO:0005829
comment: Reactome DB_ID: 3651394
comment: Converted from EntitySet in Reactome

SequenceSite2678
type: SequenceSite
position status: EQUAL
sequence position: 348

holo-POLD1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2036
component stoichiometry: Stoichiometry2035
component: SmallMolecule1134
component: Protein2196
xref: UnificationXref10381
cellular location: GO:0005829
comment: Reactome DB_ID: 3651391

SequenceSite2679
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/12482854
type: PublicationXref
id: 12482854
author: Horton, JD
author: Moon, YA
db: Pubmed
title: Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade
source: J Biol Chem 278:7335-43
year: 2003

NARFL:4Fe-4S (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2030
component stoichiometry: Stoichiometry2029
component: Protein2200
component: SmallMolecule1134
xref: UnificationXref10375
cellular location: GO:0005829
comment: Reactome DB_ID: 3651367

Exosome Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2054
component stoichiometry: Stoichiometry2055
component stoichiometry: Stoichiometry2046
component stoichiometry: Stoichiometry2056
component stoichiometry: Stoichiometry2047
component: Protein2238
component: Exosome Ring Hexamer (name copied from entity in Homo sapiens)
component: Protein2231
component: Protein2239
component: Protein2230
xref: UnificationXref10486
cellular location: GO:0005829
comment: Reactome DB_ID: 3647314

UnificationXref8281
type: UnificationXref
id: 3642166
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642166

PAK-2p34:RHG10 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2044
component stoichiometry: Stoichiometry2045
component: Protein2229
component: Protein2209
xref: UnificationXref10446
cellular location: GO:0005829
comment: Reactome DB_ID: 3645593

UnificationXref8282
type: UnificationXref
id: 3642167
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642167

holo-BRIP1 (holo-FANCJ) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2039
component stoichiometry: Stoichiometry2040
component: Protein2198
component: SmallMolecule1134
xref: UnificationXref10383
cellular location: GO:0005829
comment: Reactome DB_ID: 3651393

UnificationXref8283
type: UnificationXref
id: 3642169
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642169

UnificationXref6490
type: UnificationXref
id: 3644385
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644385

holo-XPD (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2037
component stoichiometry: Stoichiometry2038
component: Protein2197
component: SmallMolecule1134
xref: UnificationXref10382
cellular location: GO:0005829
comment: Reactome DB_ID: 3651392

UnificationXref8284
type: UnificationXref
id: REACT_92365
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92365.9

UnificationXref6491
type: UnificationXref
id: 3644387
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644387

Deadenylated mRNA:Lsm1-7 Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2066
component stoichiometry: Stoichiometry2065
component: PhysicalEntity242
component: Lsm1-7 Complex (name copied from entity in Homo sapiens)
xref: UnificationXref10506
cellular location: GO:0005829
comment: Reactome DB_ID: 3647271

Coproporphyrinogen I
type: SmallMoleculeReference
name: Coproporphyrinogen I [ChEBI:3879]
xref: UnificationXref9916

Lsm1-7 Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2057
component stoichiometry: Stoichiometry2063
component stoichiometry: Stoichiometry2060
component stoichiometry: Stoichiometry2058
component stoichiometry: Stoichiometry2059
component stoichiometry: Stoichiometry2064
component stoichiometry: Stoichiometry2061
component stoichiometry: Stoichiometry2062
component: Protein2243
component: PhysicalEntity244
component: Protein2242
component: Protein2241
component: Protein2244
component: Protein2245
component: Protein2246
component: Protein2240
xref: UnificationXref10505
cellular location: GO:0005829
comment: Reactome DB_ID: 3647263

Exosome Ring Hexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2050
component stoichiometry: Stoichiometry2053
component stoichiometry: Stoichiometry2051
component stoichiometry: Stoichiometry2052
component stoichiometry: Stoichiometry2049
component stoichiometry: Stoichiometry2048
component: Protein2233
component: Protein2235
component: Protein2234
component: Protein2237
component: Protein2232
component: Protein2236
xref: UnificationXref10481
cellular location: GO:0005829
comment: Reactome DB_ID: 3647297

UnificationXref8280
type: UnificationXref
id: 3642165
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642165

UnificationXref8289
type: UnificationXref
id: Q54NJ8
db: UniProt

UnificationXref6496
type: UnificationXref
id: Q55D85
db: UniProt

http://identifiers.org/pubmed/9712840
type: PublicationXref
id: 9712840
author: Kikuchi, Y
author: Mizutani, M
author: Katada, T
author: Imai, M
author: Hoshino, S
author: Hanaoka, F
author: Ui, M
db: Pubmed
title: Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1.
source: J Biol Chem 273:22254-9
year: 1998

UnificationXref6497
type: UnificationXref
id: 3644434
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644434

UnificationXref6498
type: UnificationXref
id: 3644436
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644436

UnificationXref6499
type: UnificationXref
id: REACT_126689
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126689.5

UnificationXref8285
type: UnificationXref
id: 500259
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500259

UnificationXref4232
type: UnificationXref
id: 3651832
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651832

UnificationXref6492
type: UnificationXref
id: REACT_110710
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_110710.9

UnificationXref8286
type: UnificationXref
id: REACT_21911
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21911.1

UnificationXref4233
type: UnificationXref
id: REACT_114037
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114037.8

UnificationXref6493
type: UnificationXref
id: CHEBI:16521
db: ChEBI

UniProt:Q55DY7
type: ProteinReference
xref: UnificationXref808
organism: Dictyostelium discoideum

UnificationXref8287
type: UnificationXref
id: 500260
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500260

UnificationXref4230
type: UnificationXref
id: 3643874
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643874

UnificationXref6494
type: UnificationXref
id: 194634
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194634

UniProt:Q55DY8
type: ProteinReference
xref: UnificationXref10235
organism: Dictyostelium discoideum

UnificationXref8288
type: UnificationXref
id: REACT_21428
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21428.1

UnificationXref4231
type: UnificationXref
id: REACT_160024
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160024.3

UnificationXref6495
type: UnificationXref
id: REACT_10504
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10504.2

RelationshipXref290
type: RelationshipXref
id: GO:0006281
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite2661
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2662
type: SequenceSite
position status: EQUAL
sequence position: 612

SequenceSite2660
type: SequenceSite
position status: EQUAL
sequence position: 339

http://identifiers.org/pubmed/15534001
type: PublicationXref
id: 15534001
author: Allison, JG
author: Williams, CC
author: Beckman, BS
author: Jones, FE
author: Vidal, GA
author: Burow, ME
author: Marrero, L
db: Pubmed
title: The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
source: J Cell Biol 167:469-78
year: 2004

UnificationXref4268
type: UnificationXref
id: 3651958
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651958

UnificationXref4267
type: UnificationXref
id: REACT_113860
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113860.8

UnificationXref4269
type: UnificationXref
id: REACT_91998
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91998.9

UnificationXref2129
type: UnificationXref
id: Q54XP2
db: UniProt

RelationshipXref298
type: RelationshipXref
id: GO:0006297
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite2669
type: SequenceSite
position status: EQUAL
sequence position: 843

UnificationXref2128
type: UnificationXref
id: 3641050
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641050

RelationshipXref297
type: RelationshipXref
id: GO:0000715
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2127
type: UnificationXref
id: MOD:00599
db: MOD

RelationshipXref296
type: RelationshipXref
id: GO:0006302
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite2667
type: SequenceSite
position status: EQUAL
sequence position: 681

UnificationXref2126
type: UnificationXref
id: DDB0233192
db: Ensembl

RelationshipXref295
type: RelationshipXref
id: GO:0006303
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite2668
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref2125
type: UnificationXref
id: 3641040
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641040

RelationshipXref294
type: RelationshipXref
id: 3642504
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642504

SequenceSite2665
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref2124
type: UnificationXref
id: Q54RX0
db: UniProt

RelationshipXref293
type: RelationshipXref
id: GO:0000724
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite2666
type: SequenceSite
position status: EQUAL
sequence position: 508

UnificationXref2123
type: UnificationXref
id: 3641247
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641247

RelationshipXref292
type: RelationshipXref
id: 3640097
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640097

SequenceSite2663
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref2122
type: UnificationXref
id: Q55CI8
db: UniProt

RelationshipXref291
type: RelationshipXref
id: GO:0000730
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite2664
type: SequenceSite
position status: EQUAL
sequence position: 508

UnificationXref8290
type: UnificationXref
id: 3642173
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642173

UnificationXref2120
type: UnificationXref
id: Q55AR8
db: UniProt

UnificationXref8291
type: UnificationXref
id: 3642174
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642174

UnificationXref2121
type: UnificationXref
id: 3641231
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641231

UnificationXref8294
type: UnificationXref
id: 3651792
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651792

UnificationXref8295
type: UnificationXref
id: REACT_98650
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98650.9

UnificationXref8292
type: UnificationXref
id: 3642176
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642176

RelationshipXref299
type: RelationshipXref
id: GO:0000716
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref8293
type: UnificationXref
id: REACT_99990
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99990.9

UniProt:Q55DZ8
type: ProteinReference
xref: UnificationXref13217
organism: Dictyostelium discoideum

UnificationXref8298
type: UnificationXref
id: REACT_2561
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2561.2

UnificationXref4263
type: UnificationXref
id: REACT_87607
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87607.9

http://identifiers.org/pubmed/12445829
type: PublicationXref
id: 12445829
author: Visser, WF
author: van Roermund, CW
author: Waterham, HR
author: Wanders, RJ
db: Pubmed
title: Identification of human PMP34 as a peroxisomal ATP transporter
source: Biochem Biophys Res Commun 299:494-7
year: 2002

UnificationXref8299
type: UnificationXref
id: CHEBI:28806
db: ChEBI

UnificationXref4264
type: UnificationXref
id: 3643409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643409

UnificationXref8296
type: UnificationXref
id: CHEBI:16192
db: ChEBI

UnificationXref4265
type: UnificationXref
id: REACT_112378
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112378.8

UnificationXref8297
type: UnificationXref
id: 109327
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109327

UnificationXref4266
type: UnificationXref
id: 3651962
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651962

UnificationXref4260
type: UnificationXref
id: REACT_84468
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_84468.9

UnificationXref4261
type: UnificationXref
id: 3643406
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643406

UnificationXref4262
type: UnificationXref
id: 3643407
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643407

SequenceSite2650
type: SequenceSite
position status: EQUAL
sequence position: 675

SequenceSite2651
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref4259
type: UnificationXref
id: 3651956
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651956

UnificationXref2119
type: UnificationXref
id: 3641014
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641014

UnificationXref4258
type: UnificationXref
id: REACT_98868
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98868.9

UnificationXref4257
type: UnificationXref
id: 3651955
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651955

UnificationXref4256
type: UnificationXref
id: REACT_31913
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31913.10

UnificationXref2116
type: UnificationXref
id: DDB0233510
db: Ensembl

SequenceSite2656
type: SequenceSite
position status: EQUAL
sequence position: 311

UnificationXref2115
type: UnificationXref
id: 3641239
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641239

SequenceSite2657
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref2118
type: UnificationXref
id: Q54ST0
db: UniProt

SequenceSite2658
type: SequenceSite
position status: EQUAL
sequence position: 338

UnificationXref2117
type: UnificationXref
id: 3641227
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641227

SequenceSite2659
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2112
type: UnificationXref
id: 3641302
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641302

SequenceSite2652
type: SequenceSite
position status: EQUAL
sequence position: 413

UnificationXref2111
type: UnificationXref
id: 3641266
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641266

SequenceSite2653
type: SequenceSite
position status: EQUAL
sequence position: 33

UnificationXref2114
type: UnificationXref
id: DDB0233221
db: Ensembl

SequenceSite2654
type: SequenceSite
position status: EQUAL
sequence position: 640

UnificationXref2113
type: UnificationXref
id: 3641223
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641223

SequenceSite2655
type: SequenceSite
position status: EQUAL
sequence position: 14

UnificationXref2110
type: UnificationXref
id: REACT_3227
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3227.1

SequenceSite2649
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref4254
type: UnificationXref
id: REACT_99614
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99614.9

UnificationXref4255
type: UnificationXref
id: 3643410
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643410

UnificationXref4252
type: UnificationXref
id: REACT_109853
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_109853.9

UnificationXref4253
type: UnificationXref
id: 3643392
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643392

UnificationXref4250
type: UnificationXref
id: 3643391
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643391

UnificationXref4251
type: UnificationXref
id: 3643408
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643408

UnificationXref2146
type: UnificationXref
id: DDB0233220
db: Ensembl

ISG15:RIG-I conjugate (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry274
component stoichiometry: Stoichiometry273
component: Protein385
component: ISG15:UBEIL/UbcH8:CEB1 (name copied from entity in Homo sapiens)
xref: UnificationXref1213
cellular location: GO:0005829
comment: Reactome DB_ID: 3643808

RelationshipXref271
type: RelationshipXref
id: GO:0045008
db: GENE ONTOLOGY
relationship type: MI:0359

Ensembl:DDB0217573
type: ProteinReference
xref: UnificationXref4979
organism: Dictyostelium discoideum

UnificationXref2147
type: UnificationXref
id: 3641243
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641243

RelationshipXref272
type: RelationshipXref
id: GO:0000703
db: GENE ONTOLOGY
relationship type: MI:0355

Ensembl:DDB0205158
type: ProteinReference
xref: UnificationXref4981
organism: Dictyostelium discoideum

UnificationXref2144
type: UnificationXref
id: Q8T295
db: UniProt

AGE adducts:Peptide:AGER-1,2,3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry263
component stoichiometry: Stoichiometry262
component: AGE adducts:Peptide
component: Protein382
xref: UnificationXref1195
cellular location: GO:0005886
comment: Reactome DB_ID: 3648330

Ensembl:DDB0190105
type: ProteinReference
xref: UnificationXref4983
organism: Dictyostelium discoideum

UnificationXref2145
type: UnificationXref
id: 3641251
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641251

dsRNA bound to RIG-I (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry269
component stoichiometry: Stoichiometry268
component stoichiometry: Stoichiometry267
component: Protein385
component: SmallMolecule5
component: PhysicalEntity39
xref: UnificationXref1204
cellular location: GO:0005829
comment: Reactome DB_ID: 3643799

RelationshipXref270
type: RelationshipXref
id: 3642874
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642874

Ensembl:DDB0233720
type: ProteinReference
xref: UnificationXref4985
organism: Dictyostelium discoideum

RelationshipXref275
type: RelationshipXref
id: GO:0004520
db: GENE ONTOLOGY
relationship type: MI:0355

Ensembl:DDB0238430
type: ProteinReference
xref: UnificationXref5013
organism: Dictyostelium discoideum

http://identifiers.org/pubmed/11896061
type: PublicationXref
id: 11896061
author: Hang, Jun
author: Dasso, Mary
db: Pubmed
title: Association of the human SUMO-1 protease SENP2 with the nuclear pore
source: J. Biol. Chem. 277:19961-6
year: 2002

http://identifiers.org/pubmed/1907800
type: PublicationXref
id: 1907800
author: Shimmoto, M
author: Sakuraba, H
author: Suzuki, Y
author: Yoshida, K
author: Oshima, A
author: Yanagisawa, N
author: Fukuhara, Y
db: Pubmed
title: Human beta-galactosidase gene mutations in GM1-gangliosidosis: a common mutation among Japanese adult/chronic cases
source: Am J Hum Genet 49:435-42
year: 1991

RelationshipXref276
type: RelationshipXref
id: 3642904
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642904

Ensembl:DDB0233388
type: ProteinReference
xref: UnificationXref5030
organism: Dictyostelium discoideum

UnificationXref2148
type: UnificationXref
id: 3641252
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641252

RelationshipXref273
type: RelationshipXref
id: 3642854
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642854

UnificationXref2149
type: UnificationXref
id: DDB0233058
db: Ensembl

RelationshipXref274
type: RelationshipXref
id: GO:0006285
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref4289
type: UnificationXref
id: 3640112
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640112

Constitutive PI3K/AKT Signaling in Cancer
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1074
pathway component: BiochemicalReaction1073
pathway component: BiochemicalReaction1069
pathway component: BiochemicalReaction1075
pathway component: BiochemicalReaction1072
pathway component: BiochemicalReaction1068
pathway component: BiochemicalReaction1070
pathway component: BiochemicalReaction1071
pathway component: BiochemicalReaction1076
evidence: Evidence1714
xref: UnificationXref11698
xref: UnificationXref11697
pathway order: PathwayStep1682
pathway order: PathwayStep1677
pathway order: PathwayStep1681
pathway order: PathwayStep1684
pathway order: PathwayStep1676
pathway order: PathwayStep1678
pathway order: PathwayStep1683
pathway order: PathwayStep1680
pathway order: PathwayStep1679
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

CNDP2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1900
component stoichiometry: Stoichiometry1901
component: SmallMolecule226
component: Protein2107
xref: UnificationXref9790
cellular location: GO:0005829
comment: Reactome DB_ID: 3649334

UnificationXref4282
type: UnificationXref
id: 3640106
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640106

CDO1:Fe2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1902
component stoichiometry: Stoichiometry1903
component: SmallMolecule225
component: Protein2108
xref: UnificationXref9805
cellular location: GO:0005829
comment: Reactome DB_ID: 3649987

UnificationXref4281
type: UnificationXref
id: 3640105
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640105

SQR:FAD (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1912
component stoichiometry: Stoichiometry1913
component: Protein2109
component: SmallMolecule767
xref: UnificationXref9825
cellular location: GO:0005743
comment: Reactome DB_ID: 3649993

UnificationXref4284
type: UnificationXref
id: 3640108
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640108

ETHE1:2Zn++ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1921
component stoichiometry: Stoichiometry1920
component: SmallMolecule793
component: Protein2112
xref: UnificationXref9834
cellular location: GO:0005759
comment: Reactome DB_ID: 3649971

UnificationXref4283
type: UnificationXref
id: 3640107
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640107

UnificationXref4286
type: UnificationXref
id: REACT_156609
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156609.3

UnificationXref4285
type: UnificationXref
id: 3643493
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643493

UnificationXref4288
type: UnificationXref
id: 3640109
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640109

UnificationXref4287
type: UnificationXref
id: 3640111
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640111

DDX41:DDX41 ligand (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry279
component stoichiometry: Stoichiometry280
component: Protein390
component: SmallMolecule97
xref: UnificationXref1232
cellular location: GO:0005829
comment: Reactome DB_ID: 3651633

dsRNA:MDA5 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry277
component stoichiometry: Stoichiometry278
component: Protein389
component: PhysicalEntity39
xref: UnificationXref1218
cellular location: GO:0005829
comment: Reactome DB_ID: 3648471

RelationshipXref279
type: RelationshipXref
id: GO:0006286
db: GENE ONTOLOGY
relationship type: MI:0359

MAT II heterotetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1891
component stoichiometry: Stoichiometry1892
component: Protein2103
component: MAT II homodimer (name copied from entity in Homo sapiens)
xref: UnificationXref9757
cellular location: GO:0005829
comment: Reactome DB_ID: 3644110

MDA5:DAK (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry276
component stoichiometry: Stoichiometry275
component: Protein389
component: Protein388
xref: UnificationXref1217
cellular location: GO:0005829
comment: Reactome DB_ID: 3648470

RelationshipXref278
type: RelationshipXref
id: 3642916
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642916

MAT II homodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1888
component stoichiometry: Stoichiometry1890
component stoichiometry: Stoichiometry1889
component: SmallMolecule383
component: Protein2102
component: SmallMolecule20
xref: UnificationXref9754
cellular location: GO:0005829
comment: Reactome DB_ID: 3644105

ISG15:UBEIL/UbcH8:CEB1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry271
component stoichiometry: Stoichiometry272
component stoichiometry: Stoichiometry270
component: PhysicalEntity40
component: Protein213
component: Protein387
xref: UnificationXref1212
cellular location: GO:0005829
comment: Reactome DB_ID: 3643807

RelationshipXref277
type: RelationshipXref
id: GO:0003906
db: GENE ONTOLOGY
relationship type: MI:0355

4x(AHCY:NAD+) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1895
component: AHCY:NAD+ (name copied from entity in Homo sapiens)
xref: UnificationXref9764
cellular location: GO:0005829
comment: Reactome DB_ID: 3644127

UnificationXref2143
type: UnificationXref
id: 3641235
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641235

HsRPC8:HsRPC9 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry298
component stoichiometry: Stoichiometry299
component: Protein404
component: PhysicalEntity46
xref: UnificationXref1275
cellular location: GO:0005829
comment: Reactome DB_ID: 3650599

AHCY:NAD+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1893
component stoichiometry: Stoichiometry1894
component: Protein2104
component: SmallMolecule376
xref: UnificationXref9763
cellular location: GO:0005829
comment: Reactome DB_ID: 3644126

UnificationXref2142
type: UnificationXref
id: Q54Y81
db: UniProt

HsRPC4:HsRPC5 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry292
component stoichiometry: Stoichiometry293
component: Protein400
component: PhysicalEntity45
xref: UnificationXref1265
cellular location: GO:0005829
comment: Reactome DB_ID: 3650592

CBS tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1897
component stoichiometry: Stoichiometry1896
component: Protein2105
component: SmallMolecule147
xref: UnificationXref9772
cellular location: GO:0005829
comment: Reactome DB_ID: 3649937

UnificationXref2141
type: UnificationXref
id: 3641024
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641024

HsRPC6:HsRPC3:HsRPC7 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry289
component stoichiometry: Stoichiometry287
component stoichiometry: Stoichiometry288
component: Protein397
component: Protein398
component: PhysicalEntity44
xref: UnificationXref1259
cellular location: GO:0005829
comment: Reactome DB_ID: 3650596

UnificationXref4280
type: UnificationXref
id: REACT_153683
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153683.3

Ensembl:DDB0192196
type: ProteinReference
xref: UnificationXref5040
organism: Dictyostelium discoideum

CTH tetramer:PXLP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1899
component stoichiometry: Stoichiometry1898
component: Protein2106
component: SmallMolecule329
xref: UnificationXref9780
cellular location: GO:0005829
comment: Reactome DB_ID: 3649952

UnificationXref2140
type: UnificationXref
id: Q54TF6
db: UniProt

RNA Polymerase III Holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry297
component stoichiometry: Stoichiometry290
component stoichiometry: Stoichiometry291
component stoichiometry: Stoichiometry286
component stoichiometry: Stoichiometry294
component stoichiometry: Stoichiometry282
component stoichiometry: Stoichiometry281
component stoichiometry: Stoichiometry283
component stoichiometry: Stoichiometry284
component stoichiometry: Stoichiometry285
component stoichiometry: Stoichiometry295
component stoichiometry: Stoichiometry296
component stoichiometry: Stoichiometry300
component: Protein391
component: Protein394
component: Protein403
component: HsRPC6:HsRPC3:HsRPC7 (name copied from entity in Homo sapiens)
component: Protein392
component: Protein399
component: Protein395
component: Protein396
component: Protein402
component: Protein393
component: HsRPC4:HsRPC5 (name copied from entity in Homo sapiens)
component: HsRPC8:HsRPC9 (name copied from entity in Homo sapiens)
component: Protein401
xref: UnificationXref1276
cellular location: GO:0005829
comment: Reactome DB_ID: 3650600

Ensembl:DDB0232052
type: ProteinReference
xref: UnificationXref5038
organism: Dictyostelium discoideum

UnificationXref2133
type: UnificationXref
id: DDB0233194
db: Ensembl

DHX9:CpG (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry301
component stoichiometry: Stoichiometry302
component: Protein405
component: PhysicalEntity47
xref: UnificationXref1283
cellular location: GO:0005829
comment: Reactome DB_ID: 3651636

RelationshipXref280
type: RelationshipXref
id: GO:0003887
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2134
type: UnificationXref
id: 3641055
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641055

CDC42-GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry303
component stoichiometry: Stoichiometry304
component: SmallMolecule2
component: Protein173
xref: UnificationXref1290
cellular location: GO:0005829
comment: Reactome DB_ID: 3646491

RelationshipXref281
type: RelationshipXref
id: 3642075
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642075

UnificationXref2135
type: UnificationXref
id: Q55A45
db: UniProt

RelationshipXref282
type: RelationshipXref
id: GO:0003909
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2136
type: UnificationXref
id: 3641045
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641045

RelationshipXref283
type: RelationshipXref
id: 3642071
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642071

UnificationXref2137
type: UnificationXref
id: DDB0302415
db: Ensembl

RelationshipXref284
type: RelationshipXref
id: GO:0006288
db: GENE ONTOLOGY
relationship type: MI:0359

Ensembl:DDB0233721
type: ProteinReference
xref: UnificationXref4969
organism: Dictyostelium discoideum

UnificationXref2138
type: UnificationXref
id: 3641032
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641032

RelationshipXref285
type: RelationshipXref
id: GO:0006284
db: GENE ONTOLOGY
relationship type: MI:0359

Ensembl:DDB0169339
type: ProteinReference
xref: UnificationXref4971
organism: Dictyostelium discoideum

UnificationXref2139
type: UnificationXref
id: 3641056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641056

RelationshipXref286
type: RelationshipXref
id: 3642893
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642893

RelationshipXref287
type: RelationshipXref
id: GO:0003908
db: GENE ONTOLOGY
relationship type: MI:0355

Ensembl:DDB0233715
type: ProteinReference
xref: UnificationXref4967
organism: Dictyostelium discoideum

UnificationXref4278
type: UnificationXref
id: 3640103
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640103

Ensembl:DDB0230087
type: ProteinReference
xref: UnificationXref4973
organism: Dictyostelium discoideum

UnificationXref4279
type: UnificationXref
id: 3640104
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640104

2xPPO:FAD (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1953
component stoichiometry: Stoichiometry1952
component: Protein2121
component: SmallMolecule1079
xref: UnificationXref9944
cellular location: GO:0005758
comment: Reactome DB_ID: 3644334

UnificationXref4273
type: UnificationXref
id: REACT_31789
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31789.10

UnificationXref4272
type: UnificationXref
id: 3651711
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651711

2xUROD (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1944
component: Protein2119
xref: UnificationXref9910
cellular location: GO:0005829
comment: Reactome DB_ID: 3644341

UnificationXref4271
type: UnificationXref
id: REACT_93981
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93981.9

2xCPO (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1949
component: Protein2120
xref: UnificationXref9934
cellular location: GO:0005758
comment: Reactome DB_ID: 3644327

UnificationXref4270
type: UnificationXref
id: 3651957
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651957

UnificationXref4277
type: UnificationXref
id: 3640099
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640099

UnificationXref4276
type: UnificationXref
id: 3640102
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640102

UnificationXref4275
type: UnificationXref
id: 3640101
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640101

UnificationXref4274
type: UnificationXref
id: 3640100
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640100

ALAS1,2
type: Complex
data source: Provenance1
member physical entity: ALAS2 homodimer (pyridoxal phosphate cofactor) (name copied from entity in Homo sapiens)
member physical entity: ALAS1 homodimer (pyridoxal phosphate cofactor) (name copied from entity in Homo sapiens)
xref: UnificationXref9871
cellular location: GO:0005759
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3644359

RelationshipXref289
type: RelationshipXref
id: GO:0006307
db: GENE ONTOLOGY
relationship type: MI:0359

ALAS1 homodimer (pyridoxal phosphate cofactor) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1928
component: Protein2115
xref: UnificationXref9868
cellular location: GO:0005759
comment: Reactome DB_ID: 3644356

RelationshipXref288
type: RelationshipXref
id: 3642042
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642042

holo-SUOX (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1927
component stoichiometry: Stoichiometry1926
component: Protein2114
component: SmallMolecule1061
xref: UnificationXref9850
cellular location: GO:0005759
comment: Reactome DB_ID: 3649944

8xALAD:Pb2+:Zn2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1934
component stoichiometry: Stoichiometry1936
component stoichiometry: Stoichiometry1935
component: SmallMolecule108
component: SmallMolecule1064
component: Protein2117
xref: UnificationXref9881
cellular location: GO:0005829
comment: Reactome DB_ID: 3644371

UnificationXref2130
type: UnificationXref
id: 3641036
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641036

Ensembl:DDB0205996
type: ProteinReference
xref: UnificationXref4977
organism: Dictyostelium discoideum

HMBS:DIPY (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1942
component stoichiometry: Stoichiometry1941
component: Protein2118
component: SmallMolecule1068
xref: UnificationXref9899
cellular location: GO:0005829
comment: Reactome DB_ID: 3644320

ALAS2 homodimer (pyridoxal phosphate cofactor) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1929
component: Protein2116
xref: UnificationXref9870
cellular location: GO:0005759
comment: Reactome DB_ID: 3644358

UnificationXref2132
type: UnificationXref
id: 3641028
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641028

8x(ALAD:Zn2+) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1931
component stoichiometry: Stoichiometry1930
component: SmallMolecule108
component: Protein2117
xref: UnificationXref9877
cellular location: GO:0005829
comment: Reactome DB_ID: 3644348

UnificationXref2131
type: UnificationXref
id: Q54NC5
db: UniProt

RelationshipXref253
type: RelationshipXref
id: 3651456
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651456

RelationshipXref254
type: RelationshipXref
id: GO:0005247
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref251
type: RelationshipXref
id: 3651447
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651447

RelationshipXref252
type: RelationshipXref
id: GO:0072345
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2168
type: UnificationXref
id: DDB0233170
db: Ensembl

UnificationXref2169
type: UnificationXref
id: 3641181
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641181

RelationshipXref250
type: RelationshipXref
id: GO:0005229
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2166
type: UnificationXref
id: Q55GD6
db: UniProt

UnificationXref2167
type: UnificationXref
id: 3641189
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641189

http://identifiers.org/pubmed/17477549
type: PublicationXref
id: 17477549
author: Wolthers, Kirsten R
author: Scrutton, Nigel S
db: Pubmed
title: Protein interactions in the human methionine synthase-methionine synthase reductase complex and implications for the mechanism of enzyme reactivation
source: Biochemistry 46:6696-709
year: 2007

2xGSTP1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1968
component: Protein2164
xref: UnificationXref10168
cellular location: GO:0005829
comment: Reactome DB_ID: 3644181

UniProt:Q6RYT0
type: ProteinReference
xref: UnificationXref5349
organism: Dictyostelium discoideum

2xGSTT1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1969
component: Protein2170
xref: UnificationXref10174
cellular location: GO:0005829
comment: Reactome DB_ID: 3644191

GSS (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1964
component stoichiometry: Stoichiometry1965
component: Protein2151
component: SmallMolecule20
xref: UnificationXref10120
cellular location: GO:0005829
comment: Reactome DB_ID: 3644118

UnificationXref2165
type: UnificationXref
id: 3641185
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641185

GST dimers
type: Complex
data source: Provenance1
member physical entity: 2xHPGDS (name copied from entity in Homo sapiens)
member physical entity: 2xGSTA3 (name copied from entity in Homo sapiens)
member physical entity: 2xGSTP1 (name copied from entity in Homo sapiens)
member physical entity: 2xGSTT2B (name copied from entity in Homo sapiens)
member physical entity: 2xGSTA1 (name copied from entity in Homo sapiens)
member physical entity: 2xGSTZ1 (name copied from entity in Homo sapiens)
member physical entity: 2xGSTT1 (name copied from entity in Homo sapiens)
xref: UnificationXref10181
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3644204

UnificationXref2164
type: UnificationXref
id: Q54SA7
db: UniProt

2xGSTA1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1966
component: Protein2152
xref: UnificationXref10154
cellular location: GO:0005829
comment: Reactome DB_ID: 3644167

UnificationXref2163
type: UnificationXref
id: 3641198
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641198

http://identifiers.org/pubmed/17600090
type: PublicationXref
id: 17600090
author: Zhang, Y
author: Tien, P
author: Li, S
author: Zhong, B
author: Zhang, M
author: Tian, Y
author: Chen, D
author: Diao, F
author: Shu, HB
author: Zhai, Z
author: Xu, LG
author: Wang, RP
db: Pubmed
title: Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase
source: Proc Natl Acad Sci U S A 104:11706-11
year: 2007

2xGSTA3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1967
component: Protein2158
xref: UnificationXref10161
cellular location: GO:0005829
comment: Reactome DB_ID: 3644174

UnificationXref2162
type: UnificationXref
id: DDB0233777
db: Ensembl

RelationshipXref259
type: RelationshipXref
id: 3648380
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648380

2x(FECH:2Fe-2S cluster) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1955
component stoichiometry: Stoichiometry1956
component: PhysicalEntity240
component: Protein2122
xref: UnificationXref9955
cellular location: GO:0005759
comment: Reactome DB_ID: 3644367

UnificationXref2161
type: UnificationXref
id: 3641193
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641193

RelationshipXref258
type: RelationshipXref
id: GO:0004777
db: GENE ONTOLOGY
relationship type: MI:0355

FMO1 (FAD cofactor) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1957
component stoichiometry: Stoichiometry1958
component: Protein2125
component: SmallMolecule1095
xref: UnificationXref10042
cellular location: GO:0005789
comment: Reactome DB_ID: 3645674

UnificationXref2160
type: UnificationXref
id: Q55BF5
db: UniProt

RelationshipXref257
type: RelationshipXref
id: 3648537
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648537

http://identifiers.org/pubmed/12474143
type: PublicationXref
id: 12474143
author: Carlson, Christopher G
author: Hoffbuhr, Kristen C
author: Kennaway, Nancy G
author: Glerum, D Moira
author: Antonicka, Hana
author: Leary, Scot C
author: Shoubridge, EA
author: Mattman, Andre
db: Pubmed
title: Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy
source: Am. J. Hum. Genet. 72:101-14
year: 2003

FMO2 (FAD, Mg2+ cofactors) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1960
component stoichiometry: Stoichiometry1961
component stoichiometry: Stoichiometry1959
component: SmallMolecule610
component: SmallMolecule1095
component: Protein2133
xref: UnificationXref10059
cellular location: GO:0005789
comment: Reactome DB_ID: 3645685

RelationshipXref256
type: RelationshipXref
id: GO:0003867
db: GENE ONTOLOGY
relationship type: MI:0355

FMO3 (FAD cofactor) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1963
component stoichiometry: Stoichiometry1962
component: SmallMolecule1095
component: Protein2141
xref: UnificationXref10076
cellular location: GO:0005789
comment: Reactome DB_ID: 3643376

RelationshipXref255
type: RelationshipXref
id: 3651502
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651502

2xGSTT2B (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1970
component: Protein2173
xref: UnificationXref10178
cellular location: GO:0005829
comment: Reactome DB_ID: 3644195

UnificationXref2159
type: UnificationXref
id: 3641219
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641219

RelationshipXref262
type: RelationshipXref
id: GO:0004016
db: GENE ONTOLOGY
relationship type: MI:0355

UniProt:Q55EA1
type: ProteinReference
xref: UnificationXref3106
organism: Dictyostelium discoideum

RelationshipXref263
type: RelationshipXref
id: 3647501
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647501

RelationshipXref264
type: RelationshipXref
id: GO:0007193
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref265
type: RelationshipXref
id: GO:0007268
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2155
type: UnificationXref
id: 3641058
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641058

SequenceSite2697
type: SequenceSite
position status: EQUAL
sequence position: 89

UnificationXref2156
type: UnificationXref
id: 3641220
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641220

SequenceSite2696
type: SequenceSite
position status: EQUAL
sequence position: 318

UniProt:Q55EA2
type: ProteinReference
xref: UnificationXref4452
organism: Dictyostelium discoideum

UnificationXref2157
type: UnificationXref
id: 3641221
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641221

RelationshipXref260
type: RelationshipXref
id: GO:0007269
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite2699
type: SequenceSite
position status: EQUAL
sequence position: 89

UnificationXref2158
type: UnificationXref
id: DDB0233421
db: Ensembl

RelationshipXref261
type: RelationshipXref
id: 3647517
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647517

SequenceSite2698
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite2693
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2692
type: SequenceSite
position status: EQUAL
sequence position: 318

SequenceSite2695
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2694
type: SequenceSite
position status: EQUAL
sequence position: 318

SequenceSite2691
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2690
type: SequenceSite
position status: EQUAL
sequence position: 237

UnificationXref4299
type: UnificationXref
id: 3640154
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640154

UnificationXref4298
type: UnificationXref
id: 3640152
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640152

UnificationXref4297
type: UnificationXref
id: 3640151
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640151

UnificationXref4296
type: UnificationXref
id: Q54F40
db: UniProt

UnificationXref4295
type: UnificationXref
id: 3640147
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640147

UnificationXref4294
type: UnificationXref
id: Q54E34
db: UniProt

FDX1L (oxidized) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1990
component stoichiometry: Stoichiometry1991
component: SmallMolecule1121
component: Protein2190
xref: UnificationXref10267
cellular location: GO:0005759
comment: Reactome DB_ID: 3649407

UnificationXref4293
type: UnificationXref
id: 3640143
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640143

UnificationXref4292
type: UnificationXref
id: 3640142
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640142

FDXR:FAD (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1987
component stoichiometry: Stoichiometry1986
component: Protein2189
component: SmallMolecule504
xref: UnificationXref10258
cellular location: GO:0005759
comment: Reactome DB_ID: 3651034

UnificationXref2152
type: UnificationXref
id: 3641057
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641057

UnificationXref4291
type: UnificationXref
id: REACT_159684
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159684.3

FDXR:FADH2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1988
component stoichiometry: Stoichiometry1989
component: Protein2189
component: SmallMolecule506
xref: UnificationXref10259
cellular location: GO:0005759
comment: Reactome DB_ID: 3651033

UnificationXref2151
type: UnificationXref
id: 3641020
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641020

UnificationXref4290
type: UnificationXref
id: 3640118
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640118

2 Iron:FXN:NFS1:ISD11:ISCU (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1980
component stoichiometry: Stoichiometry1984
component stoichiometry: Stoichiometry1983
component stoichiometry: Stoichiometry1985
component: Protein2188
component: Protein2185
component: NFS1:pyridoxal phosphate (name copied from entity in Homo sapiens)
component: 2 Iron:FXN (name copied from entity in Homo sapiens)
xref: UnificationXref10253
cellular location: GO:0005759
comment: Reactome DB_ID: 3649400

UnificationXref2154
type: UnificationXref
id: 3641019
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641019

2 Iron:FXN (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1982
component stoichiometry: Stoichiometry1981
component: SmallMolecule1081
component: Protein2186
xref: UnificationXref10252
cellular location: GO:0005759
comment: Reactome DB_ID: 3649397

UnificationXref2153
type: UnificationXref
id: 3641010
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641010

FXN:ISD11:NFS1:ISCU (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1979
component stoichiometry: Stoichiometry1978
component stoichiometry: Stoichiometry1975
component stoichiometry: Stoichiometry1974
component: Protein2188
component: Protein2185
component: NFS1:pyridoxal phosphate (name copied from entity in Homo sapiens)
component: Protein2186
xref: UnificationXref10251
cellular location: GO:0005759
comment: Reactome DB_ID: 3649411

RelationshipXref267
type: RelationshipXref
id: GO:0019104
db: GENE ONTOLOGY
relationship type: MI:0355

NFS1:pyridoxal phosphate (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1976
component stoichiometry: Stoichiometry1977
component: Protein2187
component: SmallMolecule1120
xref: UnificationXref10248
cellular location: GO:0005759
comment: Reactome DB_ID: 3649399

RelationshipXref266
type: RelationshipXref
id: GO:0045007
db: GENE ONTOLOGY
relationship type: MI:0359

2xGSTZ1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1971
component: Protein2075
xref: UnificationXref10179
cellular location: GO:0005829
comment: Reactome DB_ID: 3644196

UnificationXref2150
type: UnificationXref
id: 3641018
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641018

RelationshipXref269
type: RelationshipXref
id: GO:0008534
db: GENE ONTOLOGY
relationship type: MI:0355

2xHPGDS (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry1972
component: Homologues of HPGDS
xref: UnificationXref10180
cellular location: GO:0005829
comment: Reactome DB_ID: 3644203

RelationshipXref268
type: RelationshipXref
id: 3642878
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642878

UnificationXref2180
type: UnificationXref
id: Q54B65
db: UniProt

RelationshipXref233
type: RelationshipXref
id: GO:0005338
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2181
type: UnificationXref
id: 3641168
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641168

RelationshipXref234
type: RelationshipXref
id: 3648188
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648188

UnificationXref2182
type: UnificationXref
id: 3641173
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641173

RelationshipXref235
type: RelationshipXref
id: GO:0015250
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2183
type: UnificationXref
id: DDB0233176
db: Ensembl

RelationshipXref236
type: RelationshipXref
id: 3648044
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648044

UnificationXref2184
type: UnificationXref
id: 3641159
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641159

RelationshipXref237
type: RelationshipXref
id: GO:0006833
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2185
type: UnificationXref
id: Q54J05
db: UniProt

RelationshipXref238
type: RelationshipXref
id: 3648647
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648647

UnificationXref2186
type: UnificationXref
id: 3641160
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641160

RelationshipXref239
type: RelationshipXref
id: GO:0015078
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2187
type: UnificationXref
id: 3641203
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641203

http://identifiers.org/pubmed/18173545
type: PublicationXref
id: 18173545
author: Calamita, G
author: Svelto, M
author: Portincasa, P
author: Palasciano, G
db: Pubmed
title: Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease
source: Eur J Clin Invest 38:1-10
year: 2008

UnificationXref2189
type: UnificationXref
id: DDB0233645
db: Ensembl

UnificationXref2188
type: UnificationXref
id: 3641082
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641082

SequenceSite2600
type: SequenceSite
position status: EQUAL
sequence position: 1056

RelationshipXref230
type: RelationshipXref
id: 3648177
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648177

SequenceSite2601
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2602
type: SequenceSite
position status: EQUAL
sequence position: 632

RelationshipXref232
type: RelationshipXref
id: 3644082
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644082

SequenceSite2603
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref231
type: RelationshipXref
id: GO:0005461
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite2604
type: SequenceSite
position status: EQUAL
sequence position: 960

UnificationXref2171
type: UnificationXref
id: 3641177
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641177

RelationshipXref246
type: RelationshipXref
id: 3648727
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648727

UnificationXref2172
type: UnificationXref
id: 3641194
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641194

RelationshipXref247
type: RelationshipXref
id: GO:0004012
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref244
type: RelationshipXref
id: 3648721
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648721

UnificationXref2170
type: UnificationXref
id: DDB0233168
db: Ensembl

RelationshipXref245
type: RelationshipXref
id: GO:0043682
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2175
type: UnificationXref
id: 3641155
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641155

UnificationXref2176
type: UnificationXref
id: DDB0229922
db: Ensembl

UnificationXref2173
type: UnificationXref
id: DDB0233775
db: Ensembl

RelationshipXref248
type: RelationshipXref
id: 3648736
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648736

UnificationXref2174
type: UnificationXref
id: 3641202
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641202

RelationshipXref249
type: RelationshipXref
id: GO:0034220
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref8203
type: UnificationXref
id: REACT_3823
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3823.2

UnificationXref8204
type: UnificationXref
id: Q54QQ0
db: UniProt

UnificationXref8201
type: UnificationXref
id: CHEBI:15652
db: ChEBI

UnificationXref8202
type: UnificationXref
id: 111584
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111584

UnificationXref8200
type: UnificationXref
id: REACT_80364
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80364.9

mTORC1-mediated signalling
type: Pathway
data source: Provenance1
pathway component: REACT 158434.3
pathway component: REACT 109485.9
evidence: Evidence1564
xref: UnificationXref10918
xref: UnificationXref10917
pathway order: PathwayStep1539
pathway order: PathwayStep1536
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref8209
type: UnificationXref
id: 3641993
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641993

UnificationXref8208
type: UnificationXref
id: REACT_102501
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102501.9

UnificationXref8207
type: UnificationXref
id: 3641992
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641992

UnificationXref8206
type: UnificationXref
id: 3641990
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641990

UnificationXref8205
type: UnificationXref
id: 3641989
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641989

UnificationXref2179
type: UnificationXref
id: 3641164
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641164

UnificationXref2178
type: UnificationXref
id: Q86A14
db: UniProt

UnificationXref2177
type: UnificationXref
id: 3641172
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641172

RelationshipXref243
type: RelationshipXref
id: GO:0004008
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref242
type: RelationshipXref
id: GO:0006879
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref241
type: RelationshipXref
id: GO:0033572
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref240
type: RelationshipXref
id: 3642275
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642275

RelationshipXref215
type: RelationshipXref
id: 3647546
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647546

RelationshipXref216
type: RelationshipXref
id: GO:0015220
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref217
type: RelationshipXref
id: 3647580
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647580

RelationshipXref218
type: RelationshipXref
id: GO:0005337
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref211
type: RelationshipXref
id: 3647525
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647525

RelationshipXref212
type: RelationshipXref
id: GO:0008519
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref213
type: RelationshipXref
id: 3647551
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647551

RelationshipXref214
type: RelationshipXref
id: 3647556
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647556

UnificationXref8210
type: UnificationXref
id: P32073
db: UniProt

UnificationXref8211
type: UnificationXref
id: 3641983
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641983

UnificationXref8212
type: UnificationXref
id: 3641985
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641985

RelationshipXref219
type: RelationshipXref
id: 3642752
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642752

UnificationXref8213
type: UnificationXref
id: REACT_108131
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108131.9

UnificationXref8214
type: UnificationXref
id: CHEBI:15919
db: ChEBI

UnificationXref8215
type: UnificationXref
id: 35141
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=35141

UnificationXref8217
type: UnificationXref
id: P21900
db: UniProt

UnificationXref8216
type: UnificationXref
id: REACT_5442
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5442.2

UnificationXref8219
type: UnificationXref
id: 3642935
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642935

UnificationXref8218
type: UnificationXref
id: 3642934
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642934

http://identifiers.org/pubmed/8723348
type: PublicationXref
id: 8723348
author: Jefferson, AB
author: Pot, DA
author: Deuter-Reinhard, M
author: Masiarz, FR
author: Cousens, LS
author: Williams, LT
author: Chin, SM
author: Norris, FA
author: Kavanaugh, WM
author: Majerus, PW
db: Pubmed
title: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
source: Curr Biol 6:438-45
year: 1996

RelationshipXref210
type: RelationshipXref
id: GO:0015204
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2197
type: UnificationXref
id: REACT_5122
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5122.1

RelationshipXref228
type: RelationshipXref
id: 3648183
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648183

UnificationXref2198
type: UnificationXref
id: DDB0184228
db: Ensembl

RelationshipXref229
type: RelationshipXref
id: GO:0005457
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2195
type: UnificationXref
id: 3641109
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641109

RelationshipXref226
type: RelationshipXref
id: 3648185
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648185

http://identifiers.org/pubmed/1894595
type: PublicationXref
id: 1894595
author: Burbaum, JJ
author: Schimmel, P
db: Pubmed
title: Structural relationships and the classification of aminoacyl-tRNA synthetases
source: J Biol Chem 266:16965-8
year: 1991

UnificationXref2196
type: UnificationXref
id: 72050
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72050

RelationshipXref227
type: RelationshipXref
id: GO:0005462
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2193
type: UnificationXref
id: DDB0218327
db: Ensembl

RelationshipXref224
type: RelationshipXref
id: 3648169
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648169

UnificationXref2194
type: UnificationXref
id: 3641092
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641092

RelationshipXref225
type: RelationshipXref
id: GO:0005464
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2191
type: UnificationXref
id: 3641094
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641094

RelationshipXref222
type: RelationshipXref
id: 3648160
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648160

UnificationXref2192
type: UnificationXref
id: 3641122
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641122

RelationshipXref223
type: RelationshipXref
id: GO:0008521
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref8221
type: UnificationXref
id: 3642937
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642937

UnificationXref8222
type: UnificationXref
id: 3642938
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642938

UnificationXref2190
type: UnificationXref
id: 3641153
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641153

UnificationXref8220
type: UnificationXref
id: 3642936
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642936

UnificationXref8225
type: UnificationXref
id: 3642942
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642942

UnificationXref8226
type: UnificationXref
id: REACT_97311
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97311.9

UnificationXref8223
type: UnificationXref
id: 3642939
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642939

UnificationXref8224
type: UnificationXref
id: 3642940
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642940

UnificationXref8229
type: UnificationXref
id: 3642943
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642943

UnificationXref8228
type: UnificationXref
id: 3642946
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642946

UnificationXref8227
type: UnificationXref
id: 3642945
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642945

UniProt:Q55EE1
type: ProteinReference
xref: UnificationXref7185
organism: Dictyostelium discoideum

UniProt:Q55EE0
type: ProteinReference
xref: UnificationXref1214
organism: Dictyostelium discoideum

RelationshipXref221
type: RelationshipXref
id: 3648163
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648163

RelationshipXref220
type: RelationshipXref
id: 3642748
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642748

UnificationXref2199
type: UnificationXref
id: 3641133
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641133

UnificationXref8235
type: UnificationXref
id: REACT_3734
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3734.2

UnificationXref8234
type: UnificationXref
id: 83925
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83925

UnificationXref8237
type: UnificationXref
id: REACT_21870
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21870.1

UnificationXref8236
type: UnificationXref
id: 500173
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500173

http://identifiers.org/pubmed/21173190
type: PublicationXref
id: 21173190
author: Agarwal, AK
author: Prasad, SS
author: Garg, A
db: Pubmed
title: Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria
source: J Lipid Res 52:451-62
year: 2011

UnificationXref8231
type: UnificationXref
id: 3651782
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651782

UnificationXref4200
type: UnificationXref
id: REACT_141032
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141032.5

UnificationXref8230
type: UnificationXref
id: 3642944
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642944

UnificationXref8233
type: UnificationXref
id: CHEBI:17256
db: ChEBI

UnificationXref8232
type: UnificationXref
id: REACT_34113
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34113.10

SequenceSite2638
type: SequenceSite
position status: EQUAL
sequence position: 2

Evidence1199
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8083224
comment: Cytosolic dihydropyrimidine dehydrogenase catalyzes the reaction of thymine and NADPH + H+ to form 5,6-dihydrothymine and NADP+. The mechanism of the human reaction is inferred from that of the well-characterized pig enzyme (Yokota et al. 1994).

SequenceSite2639
type: SequenceSite
position status: EQUAL
sequence position: 531

Evidence1198
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15385443
comment: Cytosolic 3-ureidopropionase catalyzes the reaction of 3-ureidopropionate and water to form beta-alanine, CO2, and NH3 (van Kuilenberg et al. 2004).

Amino acid transport across the plasma membrane
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction165
pathway component: BiochemicalReaction167
pathway component: BiochemicalReaction163
pathway component: BiochemicalReaction166
pathway component: BiochemicalReaction164
pathway component: BiochemicalReaction162
evidence: Evidence295
xref: UnificationXref2802
xref: UnificationXref2801
xref: RelationshipXref173
pathway order: PathwayStep279
pathway order: PathwayStep282
pathway order: PathwayStep281
pathway order: PathwayStep284
pathway order: PathwayStep283
pathway order: PathwayStep280
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

Evidence1197
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9718352
comment: Cytosolic dihydropyrimidinase tetramer catalyzes the reaction of 5,6-dihydrouracil and water to form 3-ureidopropionate (Hamajima et al. 1998).

Evidence1196
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8083224
comment: Cytosolic dihydropyrimidine dehydrogenase catalyzes the reaction of uracil and NADPH + H+ to form 5,6-dihydrouracil and NADP+. The mechanism of the human reaction is inferred from that of the well-characterized pig enzyme (Yokota et al. 1994).

Evidence1195
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2178
comment: In pyrimidine salvage reactions, nucleosides and free bases generated by DNA and RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathways of pyrimidine biosynthesis (interconversion).

Evidence1194
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15689149
xref: http://identifiers.org/pubmed/7923172
comment: Cytosolic cytidine deaminase catalyzes the hydrolysis of cytidine or dexoycytidine to form uridine or deoxyuridine and ammonia (Laliberte and Momparler 1994). The active form of the enzyme is a tetramer (Chung et al. 2005).

Evidence1193
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2026611
xref: http://identifiers.org/pubmed/1063125
xref: http://identifiers.org/pubmed/8340387
xref: http://identifiers.org/pubmed/3335503
xref: http://identifiers.org/pubmed/3372530
xref: http://identifiers.org/pubmed/15733844
comment: Cytosolic thymidine kinase 1 (TK1) catalyzes the reaction of thymidine and ATP to form TMP (thymidine 5'-monophosphate) and ADP. TK1 has been purified from human spleen and from cultured cells. The enzyme is active as a homotetramer, and phosphorylates thymidine and deoxyuridine using ATP as a phosphate donor in vitro (Sherley and Kelly 1988a; Munch-Petersen et al. 1991; Birringer et al. 2005). Divalent cations are required for enzyme activity (Mg++ is preferred) (Lee and Cheng 1986), and ATP stabilizes the tetrameric form of the enzyme (Munch-Petersen et al. 1993). In cells, enzyme activity is high during S phase of the cell cycle and low otherwise, correlated with intracellular levels of thymidine kinase 1 protein (Sherley and Kelly 1988b), and consistent with a requirement for TMP synthesis in normal cells only as part of DNA replication.

SequenceSite2642
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2641
type: SequenceSite
position status: EQUAL
sequence position: 334

UnificationXref4209
type: UnificationXref
id: 3651708
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651708

SequenceSite2644
type: SequenceSite
position status: EQUAL
sequence position: 279

SequenceSite2643
type: SequenceSite
position status: EQUAL
sequence position: 334

SequenceSite2646
type: SequenceSite
position status: EQUAL
sequence position: 430

SequenceSite2645
type: SequenceSite
position status: EQUAL
sequence position: 30

SequenceSite2648
type: SequenceSite
position status: EQUAL
sequence position: 678

SequenceSite2647
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref4203
type: UnificationXref
id: 69599
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69599

UnificationXref4204
type: UnificationXref
id: REACT_2474
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2474.1

UnificationXref4201
type: UnificationXref
id: 3640128
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640128

UnificationXref4202
type: UnificationXref
id: 3640129
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640129

UnificationXref8238
type: UnificationXref
id: CHEBI:28997
db: ChEBI

UnificationXref4207
type: UnificationXref
id: 3651712
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651712

UnificationXref8239
type: UnificationXref
id: 109331
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109331

UnificationXref4208
type: UnificationXref
id: REACT_131412
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131412.5

UnificationXref4205
type: UnificationXref
id: 3640130
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640130

SequenceSite2640
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref4206
type: UnificationXref
id: REACT_140405
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140405.5

UnificationXref8248
type: UnificationXref
id: 3642182
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642182

UnificationXref8247
type: UnificationXref
id: 3642180
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642180

UnificationXref8246
type: UnificationXref
id: Q54KF3
db: UniProt

RelationshipXref209
type: RelationshipXref
id: 3647409
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647409

UnificationXref8245
type: UnificationXref
id: REACT_3820
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3820.1

RelationshipXref208
type: RelationshipXref
id: GO:0005375
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref8244
type: UnificationXref
id: 29382
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29382

UnificationXref8243
type: UnificationXref
id: CHEBI:16134
db: ChEBI

UnificationXref8242
type: UnificationXref
id: REACT_21661
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21661.1

http://identifiers.org/pubmed/8167409
type: PublicationXref
id: 8167409
author: McMahon, Jill A
author: Smolich, Beverly D
author: McMahon, Andrew P
author: Papkoff, Jackie
db: Pubmed
title: Wnt family proteins are secreted and associated with the cell surface
source: Mol. Biol. Cell 4:1267-75
year: 1993

UnificationXref8241
type: UnificationXref
id: 500172
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500172

Evidence1187
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9042911
xref: http://identifiers.org/pubmed/6893554
xref: http://identifiers.org/pubmed/18184586
xref: http://identifiers.org/pubmed/8631878
comment: The synthesis of orotidine 5'-monophosphate (OMP) from orotate and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) is catalyzed by the orotate phosphoribosyltransferase activity of the bifunctional "uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine 5'-decarboxylase)" protein. The reaction itself is freely reversible, but is pulled in the forward direction in vivo by the irreversible hydrolysis of pyrophosphate. While purified human protein has not been characterized in detail, the close similarity of the human gene to that encoding the well-studied hamster protein, and the demonstration that mutations in the human gene are associated with failure to convert orotate to UMP in vivo, provide convincing evidence that the human uridine monophosphate synthetase protein indeed catalyzes these two reactions (McClard et al. 1980; Suchi et al. 1997). The active form of the human protein is a dimer (Yablonski et al. 1996; Wittmann et al. 2008).

UnificationXref8240
type: UnificationXref
id: REACT_4959
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4959.2

RelationshipXref203
type: RelationshipXref
id: 3647383
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647383

SequenceSite2629
type: SequenceSite
position status: EQUAL
sequence position: 335

Evidence1186
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8619816
comment: The synthesis of dihydroorotate from N-carbamoyl L-aspartate is catalyzed by the dihydroorotase activity of cytosolic trifunctional CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) protein. This activity has not been directly demonstrated in experimental studies of the purified human protein, but has been inferred from the behavior of the purified hamster protein and the high degree of sequence similarity between the cloned hamster and human genes (Iwahana et al. 1996). Also on the basis of this similarity, the active human protein is annotated as a hexamer (Lee et al. 1985).

RelationshipXref202
type: RelationshipXref
id: 3647380
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647380

Evidence1189
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8631816
xref: http://identifiers.org/pubmed/8805593
comment: Deoxyuridine triphosphatase (DUT) catalyzes the hydrolysis of dUTP to form dUMP and pyrophosphate. Two isoforms of DUT are expressed, generated by alternative splicing. The major one, annotated here, is localized to the nucleoplasm (Ladner et al. 1996). The enzyme is a homotrimer (Mol et al. 1996). In the cell, this reaction depletes the supply of dUTP, preventing its incorporation into DNA, while generating dUMP, the immediate precursor of thymidine nucleotides.

RelationshipXref201
type: RelationshipXref
id: 3647374
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647374

SequenceSite2627
type: SequenceSite
position status: EQUAL
sequence position: 286

Evidence1188
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9042911
xref: http://identifiers.org/pubmed/6893554
xref: http://identifiers.org/pubmed/18184586
xref: http://identifiers.org/pubmed/8631878
comment: The decarboxylation of orotidine 5'-monophosphate (OMP) to form uridine 5'-monophosphate (UMP) is catalyzed by the orotidine 5'-phosphate decarboxylase activity of the bifunctional "uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine 5'-decarboxylase)" protein. While purified human protein has not been characterized in detail, the close similarity of the human gene to that encoding the well-studied hamster protein, and the demonstration that mutations in the human gene are associated with failure to convert orotate to UMP in vivo, provide convincing evidence that the human uridine monophosphate synthetase protein indeed catalyzes these two reactions (McClard et al. 1980; Suchi et al. 1997). The active form of the human protein is a dimer (Yablonski et al. 1996; Wittmann et al. 2008).

RelationshipXref200
type: RelationshipXref
id: GO:0005385
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite2628
type: SequenceSite
position status: EQUAL
sequence position: 2

Evidence1183
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4620886
comment: The events of human purine metabolism are conveniently, if somewhat arbitrarily, grouped into four pathways: de novo synthesis of inosine 5'-monophosphate (IMP), the biosynthesis of other purine ribo- and deoxyribonucleotides, purine salvage reactions, and purine catabolism (Watts 1974). De novo synthesis of inosine 5'-monophosphate (IMP). The purine ribonucleotide IMP is assembled on 5-phospho-alpha-D-ribose 1-diphosphate (PRPP). Purine biosynthesis [interconversion]. Purine ribo- and deoxyribonucleotide di- and triphosphates are synthesized, both from IMP and from guanosine and adenosine ribo- and deoxyribonucleotide monophosphates generated in salvage reactions. Purine salvage reactions. Purine nucleosides and free bases generated by DNA and RNA breakdown are converted to nucleotide monophosphates. Purine catabolism. The purine bases guanine and hypoxanthine are degraded to uric acid, which is excreted from the body.

RelationshipXref207
type: RelationshipXref
id: 3647433
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647433

Evidence1182
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4620886
comment: The purine bases guanine and hypoxanthine (derived from adenine by events in the purine salvage pathways) are converted to xanthine and then to uric acid, which is excreted from the body (Watts 1974). The end-point of this pathway in humans and hominoid primates is unusual. Most other mammals metabolize uric acid further to yield more soluble end products, and much speculation has centered on possible roles for high uric acid levels in normal human physiology.

RelationshipXref206
type: RelationshipXref
id: 3647395
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647395

Evidence1185
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4684686
xref: http://identifiers.org/pubmed/2995985
xref: http://identifiers.org/pubmed/8619816
comment: The synthesis of N-carbamoyl L-aspartate from carbamoyl phosphate and L-aspartate is catalyzed by the aspartate carbamoyltansferase activity of cytosolic trifunctional CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) protein (Ito and Uchino 1973; Iwahana et al. 1996). The purified human protein is active in several different oligomerization states as is its Syrian hamster homologue. The most abundant form of the latter is a hexamer, and the active human protein is annotated as a hexamer by inference (Ito and Uchino 1973; Lee et al. 1985).

RelationshipXref205
type: RelationshipXref
id: 3647392
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647392

Evidence1184
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4684686
xref: http://identifiers.org/pubmed/8619816
comment: The synthesis of carbamoyl phosphate from glutamine, bicarbonate, and ATP is catalyzed by the carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity of cytosolic trifunctional CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) protein (Ito and Uchino 1973; Iwahana et al. 1996). The purified human protein is active in several different oligomerization states, as is its Syrian hamster homologue. The most abundant form of the latter is a hexamer, and the active human protein is annotated as a hexamer by inference (Ito and Uchino 1973; Lee et al. 1985).

RelationshipXref204
type: RelationshipXref
id: 3647389
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647389

SequenceSite2633
type: SequenceSite
position status: EQUAL
sequence position: 417

Evidence1190
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2178
xref: http://identifiers.org/pubmed/6105839
comment: The pyrimidine orotate (orotic acid) is synthesized in a sequence of four reactions, deriving its atoms from glutamine, bicarbonate, and aspartate. A single multifunctional cytosolic enzyme catalyzes the first three of these reactions, while the last one is catalyzed by an enzyme associated with the inner mitochondrial membrane. In two further reactions, catalyzed by a bifunctional cytosolic enzyme, orotate reacts with 1-phosphoribosyl 5-pyrophosphate (PRPP) to yield orotidine 5'-monophosphate, which is decarboxylated to yield uridine 5'-monophosphate (UMP). While several individual reactions in this pathway are reversible, other irreversible reactions drive the pathway in the direction of UMP biosynthesis in the normal cell. All reactions are thus annotated here only in the forward direction. This pathway has been most extensively analyzed at the genetic and biochemical level in hamster cell lines. All three enzymes have also been purified from human sources, however, and the key features of these reactions have been confirmed from studies of this human material (Jones 1980; Webster et al. 2001). All other pyrimidines are synthesized from UMP. The reactions annotaed here, catalyzed by dCMP deaminase and dUTP diphosphatase yield dUMP, which in turn is converted to TMP by thymidylate synthase.

SequenceSite2632
type: SequenceSite
position status: EQUAL
sequence position: 2

Evidence1191
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11306702
xref: http://identifiers.org/pubmed/195585
comment: Cytosolic uridine-cytidine kinase 1 (UCK1) catalyzes the reactions of cytidine or uridine with ATP to form CMP or UMP and ADP (Greenberg et al. 1977; Van Rompay et al. 2001). Unpublished crystallographic data show the enzyme to be a tetramer (PDB - 2JEO).

SequenceSite2631
type: SequenceSite
position status: EQUAL
sequence position: 408

Evidence1192
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11306702
xref: http://identifiers.org/pubmed/14609716
xref: http://identifiers.org/pubmed/15130468
xref: http://identifiers.org/pubmed/195585
comment: Cytosolic uridine-cytidine kinase 2 (UCK2) catalyzes the reactions of cytidine or uridine with ATP to form CMP or UMP and ADP (Greenberg et al. 1977; Van Rompay et al. 2001). Crystallographic data show the enzyme to be a tetramer (Suzuki et al. 2004). When it is expressed as a fusion construct with green fluorescent protein, the protein localizes primarily to the cytosol of transfected CHO cells (Van Rompay et al. 2003).

SequenceSite2630
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2637
type: SequenceSite
position status: EQUAL
sequence position: 253

SequenceSite2636
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/16483939
type: PublicationXref
id: 16483939
author: Pacek, M
author: Kubota, Y
author: Takisawa, H
author: Tutter, AV
author: Walter, JC
db: Pubmed
title: Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication
source: Mol Cell 21:581-7
year: 2006

SequenceSite2635
type: SequenceSite
position status: EQUAL
sequence position: 254

http://identifiers.org/pubmed/8411712
type: PublicationXref
id: 8411712
author: Kamijo, K
author: Osumi, T
author: Hashimoto, T
db: Pubmed
title: PMP70, the 70-kDa peroxisomal membrane protein: a member of the ATP-binding cassette transporters
source: Nippon Rinsho 51:2343-52
year: 1993

SequenceSite2634
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/9110970
type: PublicationXref
id: 9110970
author: Lingner, J
author: Shevchenko, A
author: Hughes, TR
author: Lundblad, V
author: Mann, M
author: Cech, TR
db: Pubmed
title: Reverse transcriptase motifs in the catalytic subunit of telomerase
source: Science 276:561-7
year: 1997

UnificationXref8249
type: UnificationXref
id: REACT_103070
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103070.9

UnificationXref8253
type: UnificationXref
id: 3642758
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642758

UnificationXref4222
type: UnificationXref
id: 3642312
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642312

http://identifiers.org/pubmed/3049610
type: PublicationXref
id: 3049610
author: Smith, BL
author: Agre, P
author: Denker, BM
author: Kuhajda, FP
db: Pubmed
title: Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules
source: J Biol Chem 263:15634-42
year: 1988

UnificationXref8252
type: UnificationXref
id: Q54MB5
db: UniProt

UnificationXref4221
type: UnificationXref
id: 3642311
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642311

UnificationXref8255
type: UnificationXref
id: 3642761
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642761

UnificationXref4220
type: UnificationXref
id: 3642309
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642309

UnificationXref8254
type: UnificationXref
id: 3642759
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642759

UnificationXref8257
type: UnificationXref
id: Q54DD0
db: UniProt

UnificationXref8256
type: UnificationXref
id: REACT_103994
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103994.9

UnificationXref8259
type: UnificationXref
id: 3642656
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642656

UnificationXref8258
type: UnificationXref
id: 3642655
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642655

SequenceSite2616
type: SequenceSite
position status: EQUAL
sequence position: 24

SequenceSite2617
type: SequenceSite
position status: EQUAL
sequence position: 556

UnificationXref8251
type: UnificationXref
id: REACT_22019
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22019.1

SequenceSite2618
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref8250
type: UnificationXref
id: 500088
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500088

SequenceSite2619
type: SequenceSite
position status: EQUAL
sequence position: 558

SequenceSite2624
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/8901603
type: PublicationXref
id: 8901603
author: Gordon, S
author: Kodama, T
author: Suzuki, H
author: Platt, N
author: Kurihara, Y
db: Pubmed
title: Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro
source: Proc Natl Acad Sci U S A 93:12456-60
year: 1996

SequenceSite2623
type: SequenceSite
position status: EQUAL
sequence position: 784

SequenceSite2626
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2625
type: SequenceSite
position status: EQUAL
sequence position: 364

SequenceSite2620
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2622
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2621
type: SequenceSite
position status: EQUAL
sequence position: 780

UniProt:P14325
type: ProteinReference
xref: UnificationXref13292
organism: Dictyostelium discoideum

UnificationXref4229
type: UnificationXref
id: 3640116
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640116

UnificationXref4227
type: UnificationXref
id: 3643859
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643859

UnificationXref4228
type: UnificationXref
id: Q54ZN3
db: UniProt

UniProt:P14329
type: ProteinReference
xref: UnificationXref10658
organism: Dictyostelium discoideum

UnificationXref4225
type: UnificationXref
id: 3643873
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643873

Electron Transport from NADPH to Ferredoxin
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction974
pathway component: BiochemicalReaction975
evidence: Evidence1472
xref: UnificationXref10275
xref: UnificationXref10274
pathway order: PathwayStep1453
pathway order: PathwayStep1452
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref4226
type: UnificationXref
id: 3643858
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643858

UnificationXref4223
type: UnificationXref
id: REACT_142707
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142707.5

UniProt:Q8T1E3
type: ProteinReference
xref: UnificationXref9582
organism: Dictyostelium discoideum

UnificationXref4224
type: UnificationXref
id: 3643872
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643872

UnificationXref8266
type: UnificationXref
id: REACT_82887
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82887.9

UnificationXref8265
type: UnificationXref
id: 3642663
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642663

UnificationXref8264
type: UnificationXref
id: 3642661
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642661

UnificationXref4211
type: UnificationXref
id: 3651709
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651709

UnificationXref8263
type: UnificationXref
id: 3642660
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642660

UnificationXref4210
type: UnificationXref
id: REACT_146800
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146800.5

UnificationXref8269
type: UnificationXref
id: REACT_124972
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124972.1

http://identifiers.org/pubmed/17008356
type: PublicationXref
id: 17008356
author: Monroy, N
author: Kretz, C
author: Mandel, JL
author: Payrastre, B
author: Dondaine, N
author: Tronchère, H
author: Zanoteli, E
author: Rohde, HM
author: Tosch, V
author: Laporte, J
db: Pubmed
title: A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy
source: Hum Mol Genet 15:3098-106
year: 2006

UnificationXref8268
type: UnificationXref
id: 2161190
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161190

UnificationXref8267
type: UnificationXref
id: CHEBI:40196
db: ChEBI

SequenceSite2609
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8262
type: UnificationXref
id: 3642659
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642659

SequenceSite2607
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8261
type: UnificationXref
id: 3642658
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642658

SequenceSite2608
type: SequenceSite
position status: EQUAL
sequence position: 898

UnificationXref8260
type: UnificationXref
id: 3642657
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642657

SequenceSite2605
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2606
type: SequenceSite
position status: EQUAL
sequence position: 2698

SequenceSite2615
type: SequenceSite
position status: EQUAL
sequence position: 556

SequenceSite2614
type: SequenceSite
position status: EQUAL
sequence position: 334

SequenceSite2613
type: SequenceSite
position status: EQUAL
sequence position: 33

SequenceSite2612
type: SequenceSite
position status: EQUAL
sequence position: 289

SequenceSite2611
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2610
type: SequenceSite
position status: EQUAL
sequence position: 673

http://identifiers.org/pubmed/22649417
type: PublicationXref
id: 22649417
author: Siddle, Kenneth
db: Pubmed
title: Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances
source: Front Endocrinol (Lausanne) 3:34
year: 2012

UnificationXref4216
type: UnificationXref
id: 3642308
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642308

UnificationXref4217
type: UnificationXref
id: 3642364
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642364

UnificationXref4218
type: UnificationXref
id: REACT_147653
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147653.5

UnificationXref4219
type: UnificationXref
id: 3642310
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642310

UnificationXref4212
type: UnificationXref
id: REACT_137954
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137954.5

UnificationXref4213
type: UnificationXref
id: 3651710
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651710

5-PP-InsP5
type: SmallMoleculeReference
name: 5-PP-InsP5 [ChEBI:2119]
name: 5-Diphosphoinositol pentakisphosphate
xref: UnificationXref5749

UnificationXref4214
type: UnificationXref
id: REACT_30949
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30949.10

UnificationXref4215
type: UnificationXref
id: 3642306
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642306

UniProt:Q55DK5
type: ProteinReference
xref: UnificationXref11097
organism: Dictyostelium discoideum

UnificationXref89
type: UnificationXref
id: 3645138
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645138

UnificationXref88
type: UnificationXref
id: 3645137
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645137

UnificationXref87
type: UnificationXref
id: 3645132
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645132

UnificationXref85
type: UnificationXref
id: 3645112
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645112

UnificationXref86
type: UnificationXref
id: Q54HL0
db: UniProt

UnificationXref83
type: UnificationXref
id: 3645124
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645124

UnificationXref84
type: UnificationXref
id: Q55FR9
db: UniProt

UnificationXref81
type: UnificationXref
id: 3645116
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645116

UnificationXref82
type: UnificationXref
id: Q55EZ6
db: UniProt

UnificationXref80
type: UnificationXref
id: Q23924
db: UniProt

UniProt:Q55DJ9
type: ProteinReference
xref: UnificationXref13025
organism: Dictyostelium discoideum

UniProt:Q55DJ8
type: ProteinReference
xref: UnificationXref13013
organism: Dictyostelium discoideum

http://identifiers.org/pubmed/1939222
type: PublicationXref
id: 1939222
author: Cox, TM
author: Gardner, LC
author: Smith, SJ
db: Pubmed
title: Biosynthesis of delta-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in man
source: J Biol Chem 266:22010-8
year: 1991

http://identifiers.org/pubmed/12655297
type: PublicationXref
id: 12655297
author: Janicke, RU
author: Schulze-Osthoff, K
author: Fischer, U
db: Pubmed
title: Many cuts to ruin: a comprehensive update of caspase substrates
source: Cell Death Differ 10:76-100
year: 2003

http://identifiers.org/pubmed/1939224
type: PublicationXref
id: 1939224
author: Manning, DR
author: Lounsbury, KM
author: Brass, LF
author: Casey, PJ
db: Pubmed
title: Phosphorylation of Gz in human platelets. Selectivity and site of modification
source: J Biol Chem 266:22051-6
year: 1991

http://identifiers.org/pubmed/10572166
type: PublicationXref
id: 10572166
author: Dynan, WS
author: Yoo, S
db: Pubmed
title: Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein.
source: Nucleic Acids Res 27:4679-86
year: 2000

UnificationXref77
type: UnificationXref
id: 3645120
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645120

UnificationXref76
type: UnificationXref
id: Q54YD8
db: UniProt

UnificationXref79
type: UnificationXref
id: 3645136
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645136

UnificationXref78
type: UnificationXref
id: Q54HD4
db: UniProt

UnificationXref72
type: UnificationXref
id: 3645155
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645155

UnificationXref73
type: UnificationXref
id: REACT_106959
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106959.9

UnificationXref74
type: UnificationXref
id: Q55FU2
db: UniProt

UnificationXref75
type: UnificationXref
id: 3645128
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645128

UnificationXref70
type: UnificationXref
id: 3645153
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645153

UnificationXref71
type: UnificationXref
id: MI:0355
db: MI

Evidence1390
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/67547
comment: Thyroxine (T4) can be formed by the combination of two diiodotyrosines. The hormone thyrotropin can stimulate the production of T3 and T4.

UnificationXref68
type: UnificationXref
id: Q54X30
db: UniProt

UnificationXref67
type: UnificationXref
id: 3645148
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645148

UnificationXref66
type: UnificationXref
id: DDB0233617
db: Ensembl

http://identifiers.org/pubmed/18240029
type: PublicationXref
id: 18240029
author: Luttrell, LM
db: Pubmed
title: Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors
source: Mol Biotechnol 39:239-64
year: 2008

UnificationXref65
type: UnificationXref
id: 3645144
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645144

UnificationXref69
type: UnificationXref
id: 3645152
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645152

UnificationXref60
type: UnificationXref
id: 29420
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29420

Evidence1388
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/67547
comment: Tyrosines can be iodinated in thyroglobulin to produce precursors for thyroid hormone synthesis.

Evidence1389
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/67547
comment: Mono- and di-iodinated tyrosine can combine to form tri-iodothyronine (T3). The hormone thyrotropin can stimulate the production of T3 and T4.

http://identifiers.org/pubmed/8325954
type: PublicationXref
id: 8325954
author: Ciaraldi, TP
author: Hueckstaedt, TP
author: Wilkinson, W
author: Olefsky, JM
author: Garvey, WT
author: Pilch, PF
db: Pubmed
title: Insulin-responsive human adipocytes express two glucose transporter isoforms and target them to different vesicles
source: J Clin Endocrinol Metab 77:286-9
year: 1993

UnificationXref63
type: UnificationXref
id: 3645108
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645108

UnificationXref64
type: UnificationXref
id: Q54KA7
db: UniProt

UnificationXref61
type: UnificationXref
id: REACT_4014
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4014.1

UnificationXref62
type: UnificationXref
id: 3645140
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645140

Evidence1382
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19946895
xref: http://identifiers.org/pubmed/18625006
comment: Methionine salvage is a sequential pathway of six reactions that create methionine from 5'-methylthioadenosine (MTA) which is a byproduct of polyamine biosynthesis in nearly all organisms. The process happens completely in the cytosol. It is important in humans for recycling of sulphur that has to be assimilated using energy. (Pirkov et al, 2008; Albers, 2009)

Evidence1383
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15784477
xref: http://identifiers.org/pubmed/11564948
xref: http://identifiers.org/pubmed/12686127
comment: Polyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that arginine can be metabolised according to the same pathway leading to agmatine formation. Polyamines are essential for the growth, the maintenance and the function of normal cells. The complexity of their metabolism and the fact that polyamines homeostasis is tightly regulated support the idea that polyamines are essential to cell survival. Multiple abnormalities in the control of polyamines metabolism might be implicated in several pathological processes (Moinard et al., 2005). Legend for the following figure:

Evidence1380
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17786183
comment: Acireducone (1,2-Dihydroxy-3-oxo-5'-methylthiopentene) is oxidized using acireductone dioxygenase and dioxygen. There are two reactions possible, dependent on the metal cofactor: the alternative product 3-methylthiopropionate using nickel was confirmed in Klebsiella. In eukaryotes using iron(II) the result is 4-methylthio-2-oxobutanoate (MOB). (Ju et al, 2006)

Evidence1381
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11443076
comment: In the last step MOB gets transaminated to methionine. The reaction was confirmed in yeast, where several transaminases catalyze it, which appears to be also the case in rat. At the moment, the human enzymes involved are unknown but due to homology to the respective enzyme in the parasite Crithidia fasciculata we feel supported to state that human GOT is probably one of the involved transaminases. (Berger et al, 2001)

Evidence1386
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1722671
comment: The first step in the biogenesis of thyroid hormones is the oxidation of iodide (I-) by H2O2/peroxidase after being taken up by the thyroid gland. This event is known as organification.

Evidence1387
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/67547
comment: Tyrosines can be iodinated in thyroglobulin to produce precursors for thyroid hormone synthesis.

Evidence1384
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2575455
xref: http://identifiers.org/pubmed/10691773
xref: http://identifiers.org/pubmed/8101641
comment: Tyrosine hydroxylase (TH) is the first enzyme in catecholamine biosynthesis, as well as being the rate-limiting enzyme in that process. TH requires tetrahydrobiopterin and uses iron as a cofactor in the 3,4-hydroxylation of tyrosine to produce dopa. Four isoforms of TH are expressed in the human brain and all have enzymatic activity (Nagatsu, T, 1989; Lewis, DA et al, 1993).

http://identifiers.org/pubmed/18155917
type: PublicationXref
id: 18155917
author: Paus, R
author: Zmijewski, MA
author: Slominski, A
author: Tobin, DJ
author: Wortsman, J
db: Pubmed
title: Melatonin in the skin: synthesis, metabolism and functions
source: Trends Endocrinol Metab 19:17-24
year: 2008

http://identifiers.org/pubmed/14739288
type: PublicationXref
id: 14739288
author: Dowd, LO
author: Augustin, R
author: Phay, JE
author: Moley, JF
author: Moley, KH
author: Carayannopoulos, MO
db: Pubmed
title: Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking
source: J Biol Chem 279:16229-36
year: 2004

Evidence1385
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/363400
xref: http://identifiers.org/pubmed/1684650
xref: http://identifiers.org/pubmed/10691773
comment: The catecholamine neurotransmitters dopamine, noradrenaline and adrenaline are found in nervous tissue of animals. They are synthesized in catecholaminergic neurons by four enzymes from tyrosine to adrenaline: tyrosine hydroxylase (TH); aromatic L-amino acid decarboxylase (AADC); dopamine beta-hydroxylase (DBH); and phenylethanolamine N-methyltransferase (PNMT).

http://identifiers.org/pubmed/16321791
type: PublicationXref
id: 16321791
author: Joseph, JW
author: MacDonald, PE
author: Rorsman, P
db: Pubmed
title: Glucose-sensing mechanisms in pancreatic beta-cells
source: Philos Trans R Soc Lond B Biol Sci 360:2211-25
year: 2005

UnificationXref55
type: UnificationXref
id: REACT_85994
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85994.9

UnificationXref54
type: UnificationXref
id: 3652084
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652084

UnificationXref57
type: UnificationXref
id: O00909
db: UniProt

UnificationXref56
type: UnificationXref
id: GO:0000139
db: GENE ONTOLOGY

UnificationXref59
type: UnificationXref
id: CHEBI:17552
db: ChEBI

UnificationXref58
type: UnificationXref
id: 3645107
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645107

Evidence1399
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10484776
xref: http://identifiers.org/pubmed/10524214
comment: Peroxisomal GRHPR catalyzes the reaction of glyoxylate and NADPH + H+ to form glycolate and NADP+. The active form of the enzyme is a monomer (Rumsby and Cregeen 1999); mutations in it are associated with primary hyperoxaluria type II (Cramer et al. 1999).

UnificationXref50
type: UnificationXref
id: ECO:0000203
db: EVIDENCE CODE

UnificationXref51
type: UnificationXref
id: 3652083
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652083

UnificationXref52
type: UnificationXref
id: REACT_89847
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89847.9

UnificationXref53
type: UnificationXref
id: MI:0359
db: MI

Evidence1391
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1400883
comment: Iodothyronine deiodinases 1 and 2 (DIO1/2) are the vertebrate enzymes responsible for the deiodination of the prohormone thyroxine (T4; 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine). DIO1/2 activity is critical for appropriate T3 levels in the brain during development.

Evidence1392
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17016550
comment: The iodothyronine deiodinases (DIO) are dimeric, membrane-bound enzymes that regulate the activity of thyroid hormone by removal of specific iodines from the precursor T4. There are three types of DIOs in humans; types I, II and III (D1, D2 and D3 respectively) which are proteins of about 250 residues that contain a selenocysteine at their active site. Signaling by thyroid hormone can change in individual tissues by this activation or inactivation process, even when serum concentrations of the hormone remain normal. Generally, cell types express just one type of DIO at any one time. The exception is the pituitary gland which expresses all three.

Evidence1393
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3297964
comment: Thyroxine (3,5,3',5'-tetraiodothyronine, T4) promotes normal growth and development. It also regulates heat and energy production. T4 is released from the thyroid gland, the largest endocrine organ in the human body. The primary hormone released is T4 although T3 (3,5,3'-triiodothyronine) is also released in small quantities. Tyrosine residues in thyroglobulin (a glycoprotein scaffold containing many tyrosine residues) are iodinated to form mono- or diiodo-tyrosine which can then couple to form either T3 or T4.

Evidence1394
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12379098
xref: http://identifiers.org/pubmed/10872454
xref: http://identifiers.org/pubmed/12511643
comment: The first and rate limiting step in serotonin (5-HT) biosynthesis is catalyzed by tryptophan hydroxylase. The enzyme requires iron(II), tetrahydrobiopterin, and dioxygen cofactors for the hydroxylation of L-tryptophan to 5-hydroxytryptophan. Tryptophan hydroxylase belongs to a small family of monooxygenases that utilize tetrahydrobiopterins. Other members are phenylalanine hydroxylase and tyrosine hydroxylase (Fitzpatrick, PF, 1999; Walther et al, 2003).

Evidence1395
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16942634
xref: http://identifiers.org/pubmed/18155917
comment: Serotonin (5-HT) is a hormone and neurotransmitter used for regulatory purposes in animal CNS. In the human brain, serotonin is involved in many physiological functions such as sleep, pain, mood and is the precursor to melatonin, a hormone produced in the pineal gland.

Evidence1396
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16942634
xref: http://identifiers.org/pubmed/10691773
xref: http://identifiers.org/pubmed/3297964
comment: Catecholamines and thyroxine are synthesized from tyrosine, and serotonin and melatonin from tryptophan.

Evidence1397
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17088322
xref: http://identifiers.org/pubmed/16616139
comment: Peroxisomal D-amino-acid oxidase catalyzes the reaction of glycine, water, and O2 to form glyoxylate, H2O2, and NH4+. The active form of the enzyme is a homodimer and has FAD as a cofactor (Kawazoe et al. 2006; Molla et al. 2006).

Evidence1398
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12899834
xref: http://identifiers.org/pubmed/3416563
xref: http://identifiers.org/pubmed/2363689
xref: http://identifiers.org/pubmed/15802217
xref: http://identifiers.org/pubmed/1703535
comment: Alanine-glyoxylate transaminase (AGXT) catalyzes the irreversible reaction of glyoxylate and alanine to form glycine and pyruvate (Danpure and Jennings 1988). The active form of the enzyme is a homodimer (Zhang et al. 2003) with one molecule of pyridoxal phosphate bound to each subunit (Coulter-Mackie et al. 2005). Mutations in this enzyme are associated with primary hyperoxaluria type I. Mutant alleles encode both catalytically inactive proteins and active ones that are mis-localized to mitochondria (Purdue et al. 1990; Takada et al. 1990).

UnificationXref8308
type: UnificationXref
id: REACT_21894
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21894.1

UnificationXref49
type: UnificationXref
id: REACT_32263
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32263.10

UnificationXref6515
type: UnificationXref
id: 194688
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194688

UnificationXref8309
type: UnificationXref
id: Q54XC1
db: UniProt

UnificationXref6516
type: UnificationXref
id: REACT_10528
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10528.1

UnificationXref47
type: UnificationXref
id: 3645404
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645404

UnificationXref6517
type: UnificationXref
id: CHEBI:18364
db: ChEBI

UnificationXref48
type: UnificationXref
id: 3645405
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645405

UnificationXref6518
type: UnificationXref
id: 194704
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194704

UnificationXref8304
type: UnificationXref
id: CHEBI:17172
db: ChEBI

UnificationXref45
type: UnificationXref
id: 3645400
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645400

UnificationXref6511
type: UnificationXref
id: 194725
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194725

UnificationXref8305
type: UnificationXref
id: 109328
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109328

UnificationXref46
type: UnificationXref
id: 3645402
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645402

UnificationXref6512
type: UnificationXref
id: REACT_10783
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10783.1

UnificationXref8306
type: UnificationXref
id: REACT_3479
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3479.2

UnificationXref43
type: UnificationXref
id: 3645398
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645398

UnificationXref6513
type: UnificationXref
id: 194681
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194681

UniProt:Q55E06
type: ProteinReference
xref: UnificationXref9875
organism: Dictyostelium discoideum

UnificationXref8307
type: UnificationXref
id: 500118
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500118

UnificationXref44
type: UnificationXref
id: 3645399
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645399

UnificationXref6514
type: UnificationXref
id: REACT_10169
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10169.1

UnificationXref6519
type: UnificationXref
id: REACT_10787
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10787.1

http://identifiers.org/pubmed/12573255
type: PublicationXref
id: 12573255
author: Hegele, RA
author: Cao, H
author: Mok, A
db: Pubmed
title: Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase
source: Genomics 81:1-5
year: 2003

Evidence1365
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10672018
comment: Cytosolic kynurenine 3-monooxygenase catalyzes the reaction of L-kynurenine, NADPH + H+, and O2 to form 3-hydroxy-L-kynurenine, NADP+, and H2O.

Evidence1364
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16376499
comment: CCBL2 (KAT 3) catalyzes the reaction of kynurenine and pyruvate to form 4-(2-aminophenyl)-2,4-dioxobutanoate and alanine. CCBL2 is known only as the predicted protein product of a cloned human gene closely homologous to CCBL1 (Yu et al. 2006) and all of the structural and catalytic properties annotated here are inferred from those of CCBL1.

Evidence1363
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7883047
xref: http://identifiers.org/pubmed/15364907
xref: http://identifiers.org/pubmed/19338303
xref: http://identifiers.org/pubmed/13069505
xref: http://identifiers.org/pubmed/8294935
comment: CCBL1 (KAT 1) catalyzes the reaction of kynurenine and pyruvate to form 4-(2-aminophenyl)-2,4-dioxobutanoate and alanine. The active form of CCBL1 is a homodimer with one molecule of pyridoxal phosphate bound to each monomer (Baran et al. 1994; Han et al. 2009; Rossi et al. 2004). The enzyme's cytosolic localization is inferred from that of recombinant protein overexpressed in transfected cells (Perry et al. 1995). The pH optimum observed for CCBL1 in vitro is 9.5 - 10.0, so its role in kynurenine metabolism in vivo is not clear (Baran et al. 1994). Biochemical studies of CCBL1 activity in vitro (e.g., Baren et al. 1994) invariably measure kynurenic acid as the reaction product, not 4-(2-aminophenyl)-2,4-dioxobutanoate, the product to be expected from transamination of kynurenine. The condensation of 4-(2-aminophenyl)-2,4-dioxobutanoate and elimination of a water molecule to form kynurenic acid has not been demonstrated directly. As noted by Miller et al. (1953), discussing their characterization of a bacterial form of the enzyme, "The keto acid assumed to be formed prior to ring closure in the conversion of kynurenine to kynurenic acid has not yet been detected. In principle, such detection should be possible, since it is sufficiently stable to have been synthesized. It also remains to be established whether ring closure is spontaneous, enzymatic, or both. The formation of kynurenic acid from L-kynurenine by the L-amino acid oxidase of Neurospora suggests, however, that ring closure can be spontaneous, unless the somewhat improbable assumption is made that Neurospora filtrate contained the ring-closing enzyme."

Evidence1362
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8666386
xref: http://identifiers.org/pubmed/1907934
xref: http://identifiers.org/pubmed/11469796
comment: Cytosolic tryptophan 2,3-dioxygenase (TDO) tetramer catalyzes the conversion of L-tryptophan and oxygen to formylkynurenine. The structure and catalytic properties of the human enzyme are inferred from the close similarity of its predicted amino acid sequence (Comings et al. 1995) to that of the well-studied rat enzyme (Dick et al. 2001). In the body, TDO is found predominantly in the liver and is induced by metabolites such as tryptophan and histidine, and by glucocorticoids. These properties, together with TDO's narrow substrate specificity, are consistent with the hypothesis that the enzyme functions functions primarily in tryptophan catabolism and NAD biosynthesis (Taylor and Feng 1991).

Evidence1361
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2417
comment: Proline is catabolized in two steps to yield L-glutamate gamma-semialdehyde, which can react further with glutamate to yield ornithine and alpha-ketoglutarate (annotated as a reaction of amino acid synthesis and interconversion) or with NAD+ to yield glutamate and NADH + H+ (Phang et al. 2001).

http://identifiers.org/pubmed/8246982
type: PublicationXref
id: 8246982
author: Wagner, BJ
author: Brewer, G
author: DeHaven, K
author: Schaefer, AW
author: Long, L
author: Crater, D
author: Ehrenman, K
author: Zhang, W
author: DeMaria, CT
db: Pubmed
title: Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1
source: Mol Cell Biol 13:7652-65
year: 1993

Evidence1360
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9700195
xref: http://identifiers.org/pubmed/8621661
xref: http://identifiers.org/pubmed/3944130
comment: Mitochondrial delta-1-pyrroline-5-carboxylate dehydrogenase (ALDH4A1) catalyzes the reaction of L-glutamate gamma-semialdehyde and NAD+ to form glutamate and NADH + H+ (Hu et al. 1996). The enzyme is a dimer (Forte-McRobbie and Pietruszko 1986). ALDH4A1 mutations cause type II hyperprolinemia in vivo (Geraghty et al. 1998).

UniProt:Q55E04
type: ProteinReference
xref: UnificationXref7187
organism: Dictyostelium discoideum

UnificationXref8301
type: UnificationXref
id: REACT_2753
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2753.2

UnificationXref42
type: UnificationXref
id: 3645397
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645397

UnificationXref8300
type: UnificationXref
id: 109330
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109330

UnificationXref41
type: UnificationXref
id: 3645396
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645396

UnificationXref8303
type: UnificationXref
id: REACT_21512
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21512.1

UnificationXref40
type: UnificationXref
id: 3645395
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645395

UnificationXref6510
type: UnificationXref
id: GO:0005635
db: GENE ONTOLOGY

UnificationXref8302
type: UnificationXref
id: 500120
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500120

Evidence1369
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/13069505
xref: http://identifiers.org/pubmed/18056995
comment: AADAT dimer localized in the mitochondrial matrix catalyzes the reaction of kynurenine and 2-oxoglutarate to form 4-(2-aminophenyl)-2,4-dioxobutanoate and glutamate (Han et al. 2008). Biochemical studies of kynurenine transamination in vitro invariably measure kynurenic acid, not 4-(2-aminophenyl)-2,4-dioxobutanoate, the expected transamination product. As noted by Miller et al. (1953), "The keto acid assumed to be formed prior to ring closure in the conversion of kynurenine to kynurenic acid has not yet been detected. In principle, such detection should be possible, since it is sufficiently stable to have been synthesized. It also remains to be established whether ring closure is spontaneous, enzymatic, or both. The formation of kynurenic acid from L-kynurenine by the L-amino acid oxidase of Neurospora suggests, however, that ring closure can be spontaneous, unless the somewhat improbable assumption is made that Neurospora filtrate contained the ring-closing enzyme."

http://identifiers.org/pubmed/15215243
type: PublicationXref
id: 15215243
author: Graf, SA
author: Shirihai, OS
author: Corson, ED
author: Haigh, SE
db: Pubmed
title: Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me)
source: J Biol Chem 279:42954-63
year: 2004

Evidence1368
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12140278
comment: At the beginning of this reaction, 1 molecule of '2-Amino-3-carboxymuconate semialdehyde' is present. At the end of this reaction, 1 molecule of 'CO2', and 1 molecule of '2-Aminomuconate semialdehyde' are present. This reaction takes place in the 'cytoplasm' and is mediated by the 'carboxy-lyase activity' of '2-amino-3-carboxymuconate-6-semialdehyde decarboxylase homodimer'.

Evidence1367
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7514594
comment: Cytosolic 3-hydroxyanthranilate oxygenase catalyzes the reaction of 3-hydroxyanthranilate and O2 to form 2-amino-3-carboxymuconate semialdehyde.

Evidence1366
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9180257
comment: Cytosolic kynureninase catalyzes the hydrolysis of 3-hydroxy-L-kynurenine to form L-alanine and 3-hydroxyanthranilate.

UnificationXref36
type: UnificationXref
id: 3645401
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645401

UnificationXref6528
type: UnificationXref
id: 3644609
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644609

UnificationXref37
type: UnificationXref
id: 3645392
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645392

UnificationXref6529
type: UnificationXref
id: 3644611
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644611

UnificationXref38
type: UnificationXref
id: 3645393
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645393

UnificationXref6526
type: UnificationXref
id: 194633
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194633

UnificationXref39
type: UnificationXref
id: 3645394
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645394

UnificationXref6527
type: UnificationXref
id: REACT_10958
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10958.1

UnificationXref32
type: UnificationXref
id: 3645403
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645403

UnificationXref6524
type: UnificationXref
id: 3644602
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644602

UniProt:Q55DN5
type: ProteinReference
xref: UnificationXref3510
organism: Dictyostelium discoideum

UnificationXref33
type: UnificationXref
id: 3645390
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645390

UnificationXref6525
type: UnificationXref
id: REACT_155218
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155218.3

UnificationXref34
type: UnificationXref
id: 3645389
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645389

UnificationXref6522
type: UnificationXref
id: Q54PP1
db: UniProt

UnificationXref35
type: UnificationXref
id: 3645391
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645391

UnificationXref6523
type: UnificationXref
id: 3644600
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644600

Evidence1374
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10029540
xref: http://identifiers.org/pubmed/11583147
comment: S-Adenosylmethionine decarboxylase belongs to a small class of amino acid decarboxylases that use a covalently bound pyruvate as a prosthetic group. It is an essential enzyme for polyamine biosynthesis and provides an important target for the design of anti-parasitic and cancer chemotherapeutic agents. It catalyzes the formation of the aminopropyl group donor in the biosynthesis of the polyamines spermidine and spermine. These pyruvoyl-dependent decarboxylases also form amines such as histamine, decarboxylated S-adenosylmethionine, phosphatidylethanolamine (a component of membrane phospholipids), and -alanine (a precursor of coenzyme A), which are all of critical importance in cellular physiology and provide important targets for drug design.

Evidence1373
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2433
comment: The urea cycle yields urea, the major form in which excess nitrogen is excreted from the human body, and the amino acid arginine (Brusilow and Horwich 2001). It consists of four reactions: that of ornithine and carbamoyl phosphate to form citrulline, of citrulline and aspartate to form argininosuccinate, the cleavage of argininosuccinate to yield fumarate and arginine, and the cleavage of arginine to yield urea and re-form ornithine. The carbamoyl phosphate consumed in this cycle is synthesized in the mitochondria from bicarbonate and ammonia, and this synthesis in turn is dependent on the presence of N-acetylglutamate, which allosterically activates carbamoyl synthetase I enzyme. The synthesis of N-acetylglutamate is stimulated by high levels of arginine. Increased levels of free amino acids, indicated by elevated arginine levels, thus stimulate urea synthesis. Two enzymes catalyze the hydrolysis of arginine to yield ornithine and urea. Cytosolic ARG1 is the canonical urea cycle enzyme. Mitochondrial ARG2 likewise catalyzes urea production from arginine and may have a substantial sparing effect in patients lacking ARG1 enzyme, so its reaction is annotated here although the role of ARG2 under normal physiological conditions remains unclear.

Evidence1376
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19620624
comment: Equilibrium between 5'-methylthio ribose-1-phosphate and 5'-methylthio ribulose-1-phosphate is catalyzed by 5'-methylthio ribose-1-phosphate isomerase. (Kabuyama et al, 2009)

Evidence1375
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2069720
comment: Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.

Evidence1370
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1772073
comment: Tryptophan is catabolized in seven steps to yield aminomuconate. Intermedistes in this process are used as well for the synthesis of serotonin and kynurenine (Peters 1991).

Evidence1372
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12948741
xref: http://identifiers.org/pubmed/10369256
xref: http://identifiers.org/pubmed/12807890
comment: The mitochondrial ornithine transporters SLC25A15 and SLC25A2 mediate the exchange of cytosolic ornithine for citrulline from the mitochondrial matrix. SLC25A15 was the first protein shown to have this function, identified because mutations in the protein are associated with elevated levels of ammonia, ornithine, and citrulline in affected individuals (Camacho et al. 1999). The second transporter, SLC25A2, identified later, is also expressed in normal cells and their apparently partly redundant function may explain the relatively mild symptoms associated with SLC25A15 deficiency compared to other defects of the urea cycle (Fiermonte et al. 2003).

Evidence1371
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12459178
xref: http://identifiers.org/pubmed/15050968
comment: Mitochondrial N acetylglutamate synthetase (NAGS) catalyzes the reaction of glutamate and acetyl-CoA to form N-acetylglutamate and CoA. NAGS is activated by arginine and the N-acetylglutamate produced in the reaction in turn is required to activate carbamoyl synthetase I. Consistent with this regulatory role in urea synthesis, NAGS mutations in humans are associated with hyperammonemia (Caldovic et al. 2002; Morizono et al. 2004).

http://identifiers.org/pubmed/11964406
type: PublicationXref
id: 11964406
author: Nicchitta, CV
author: Potter, MD
db: Pubmed
title: Endoplasmic reticulum-bound ribosomes reside in stable association with the translocon following termination of protein synthesis
source: J Biol Chem 277:23314-20
year: 2002

UnificationXref6521
type: UnificationXref
id: REACT_10513
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10513.1

UnificationXref6520
type: UnificationXref
id: 194668
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194668

UnificationXref31
type: UnificationXref
id: GO:0012507
db: GENE ONTOLOGY

UnificationXref30
type: UnificationXref
id: 3645388
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645388

Evidence1378
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: The human enzyme with 5'-methylthio ribulose-1-phosphate isomerase activity is probably produced from the APIP gene, according to its orthology with the yeast Mde1p enzyme.

Evidence1377
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19620624
comment: Equilibrium between 5'-methylthio ribose-1-phosphate and 5'-methylthio ribulose-1-phosphate is catalyzed by 5'-methylthio ribose-1-phosphate isomerase. (Kabuyama et al, 2009)

http://identifiers.org/pubmed/6323448
type: PublicationXref
id: 6323448
author: Cline, A
author: Moulton, AD
author: Nienhuis, AW
author: Chen, MJ
author: Humphries, RK
author: Shimada, T
author: Maizel, J
db: Pubmed
title: The functional human dihydrofolate reductase gene
source: J Biol Chem 259:3933-43
year: 1984

Evidence1379
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15843022
comment: Acireductone synthase (also: enolase-phosphatase E1) catalyzes the dephosphorylation and conversion to enolate of 2,3-dioxo-5'-methylthiopentane-1-phosphate, yielding acireductone. (Wang et al, 2005)

UnificationXref23
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

UnificationXref24
type: UnificationXref
id: CHEBI:15996
db: ChEBI

UnificationXref21
type: UnificationXref
id: 3645376
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645376

UnificationXref22
type: UnificationXref
id: 3645377
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645377

UnificationXref27
type: UnificationXref
id: 3645353
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645353

UnificationXref28
type: UnificationXref
id: 3645354
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645354

UnificationXref25
type: UnificationXref
id: 29438
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438

UnificationXref26
type: UnificationXref
id: REACT_2875
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2875.1

UnificationXref29
type: UnificationXref
id: 3645378
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645378

Evidence1343
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18056996
xref: http://identifiers.org/pubmed/18056995
xref: http://identifiers.org/pubmed/12126930
comment: Kynurenine/alpha-aminoadipate aminotransferase (AADAT) catalyzes the reversible reaction of alpha-ketoadipate and glutamate to form alpha-aminoadipate and alpha-ketoglutarate. Crystallographic studies have demonstrated that active AADAT enzyme is a homodimer with a pyridoxal phosphate moiety covalently attached to each monomer (Han et al. 2008; Rossi et al. 2008). The enzyme is inferred to be located within the mitochondrion because of a mitochondrial localization sequence motif at the aminoterminal end of the AADAT polypeptide (Goh et al. 2002).

Evidence1342
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18056996
xref: http://identifiers.org/pubmed/18056995
xref: http://identifiers.org/pubmed/12126930
comment: Kynurenine/alpha-aminoadipate aminotransferase (AADAT) catalyzes the reversible reaction of alpha-aminoadipate and alpha-ketoglutarate to form alpha-ketoadipate and glutamate. Crystallographic studies have demonstrated that active AADAT enzyme is a homodimer with a pyridoxal phosphate moiety covalently attached to each monomer (Han et al. 2008; Rossi et al. 2008). The enzyme is inferred to be located within the mitochondrion because of a mitochondrial localization sequence motif at the aminoterminal end of the AADAT polypeptide (Goh et al. 2002).

Evidence1341
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19885858
xref: http://identifiers.org/pubmed/16491085
comment: Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) catalyzes the reaction of alpha-aminoadipic semialdehyde and NAD+ to form alpha-aminoadipate and NADH + H+ (Mills et al. 2006). Unpublished crystallographic data (PDB 2J6L) indicate that the enzyme is a homodimer. Recent immunofluorescence studies of both endogenous and GFP-tagged ALDH7A1 proteins in cultured human embryonic kidney cells indicate that the protein is present in both mitochondria and the cytosol (Wong et al. 2010).

Evidence1340
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10775527
xref: http://identifiers.org/pubmed/6434529
comment: The saccharopine dehydrogenase activity of lysine-ketoglutarate reductase / saccharopine dehydrogenase homotetramer in the mitochondrial matrix catalyzes the reaction of saccharopine (N6-(L-1,3-Dicarboxypropyl)-L-lysine), H2O, and NAD+ to form 'L-2-Aminoadipate 6-semialdehyde, glutamate, and NADH + H+ (Markovitz et al. 1984; Sacksteder et al. 2001).

Evidence1347
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2399
xref: http://identifiers.org/pubmed/6434529
xref: PublicationXref2398
xref: http://identifiers.org/pubmed/12126930
comment: In humans, most catabolism of L-lysine normally proceeds via a sequence of seven reactions which feeds into the pathway for fatty acid catabolism. In the first two reactions, catalyzed by a single enzyme complex, lysine is combined with alpha-ketoglutarate to form saccharopine, which in turn is cleaved and oxidized to yield glutamate and alpha-ketoadipic semialdehyde. The latter molecule is further oxidized to alpha-ketoadipate. Alpha-ketoadipate is oxidatively decarboxylated by the alpha-ketoglutarate dehydrogenase complex (the same enzyme complex responsible for the conversion of alpha-ketoglutarate to succinyl-CoA in the citric acid cycle), yielding glutaryl-CoA. Glutaryl-CoA is converted to crotonyl-CoA, crotonyl-CoA is converted to beta-hydroxybutyryl-CoA, and beta-hydroxybutyryl-CoA is converted to acetoacetyl-CoA. The products of lysine catabolism are thus exclusively ketogenic; i.e., under starvation conditions they can be used for the synthesis of ketone bodies, beta-hydroxybutyrate and acetoacetate, but not for the net synthesis of glucose (Cox 2001; Goodman and Freeman 2001).

Evidence1346
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18775954
xref: http://identifiers.org/pubmed/15274622
comment: Mitochondrial glutaryl-CoA dehydrogenase (GCDH) catalyzes the reaction of glutaryl-CoA and FAD to form crotonyl-CoA, FADH2, and CO2. The active enzyme is a tetramer of GCDH polypeptides lacking a 44-residue aminoterminal mitochondrial targeting sequence. Mutations in GCDH cause glutaric aciduria type 1 in vivo (Fu et al. 2004; Keyser et al. 2008).

Evidence1345
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15946682
xref: http://identifiers.org/pubmed/9727038
xref: http://identifiers.org/pubmed/2188967
xref: http://identifiers.org/pubmed/11752427
comment: The mitochondrial alpha-ketoglutarate dehydrogenase complex catalyzes the reaction of alpha-ketoadipate, CoASH, and NAD+ to form glutaryl-CoA, CO2, and NADH. The enzyme complex contains multiple copies of three different proteins, E1 (OGDH), E2 (DLST), and E3 (DLD), each with distinct catalytic activities (Reed and Hackert 1990; Zhou et al 2001). The reaction starts with the oxidative decarboxylation of alpha-ketoadipate catalyzed by E1alpha and beta (alpha ketoglutarate dehydrogenase). Lipoamide cofactor associated with E1 is reduced at the same time. Next, the glutaryl group derived from alpha ketoglutarate is transferred to coenzyme A in two steps catalyzed E2 (dihydrolipolyl transacetylase). Finally, the oxidized form of lipoamide is regenerated and electrons are transferred to NAD+ in two steps catalyzed by E3 (dihydrolipoyl dehydrogenase). The biochemical details of this reaction have been worked out with alpha ketoglutarate dehydrogenase complex and subunits purified from bovine tissue (McCartney et al. 1998). While all of the human proteins are known as predicted protein products of cloned genes, direct experimental evidence for their functions is available only for E3 (DLD) (Brautigam et al. 2005).

Evidence1344
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11083877
comment: SLC25A21, the mitochondrial 2-oxodicarboxylate carrier, mediates the exchange of 2-oxoadipate and 2-oxoglutarate across the inner mitochondrial membrane. While the exchange is reversible, under physiological conditions it proceeds in the direction of 2-oxoadipate import into the mitochondrial matrix and 2-oxoglutarate export (Fiermonte et al. 2001).

UnificationXref20
type: UnificationXref
id: Q54T59
db: UniProt

Evidence1349
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2400
xref: http://identifiers.org/pubmed/9642259
comment: Cytosolic phenylalanine hydroxylase (PAH) catalyzes the reaction of phenylalanine, molecular oxygen and tetrahydrobiopterin to form tyrosine, water, and 4 alpha-hydroxytetrahydrobiopterin. The active form of the enzyme is a homotetramer (Fusetti et al. 1998).

Evidence1348
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7883047
xref: http://identifiers.org/pubmed/15364907
xref: http://identifiers.org/pubmed/19338303
xref: http://identifiers.org/pubmed/8294935
comment: CCBL1 (KAT 1) catalyzes the reaction of phenylalanine and pyruvate to form 3-(indol-3-yl)pyruvate and alanine. The active form of CCBL1 is a homodimer with one molecule of pyridoxal phosphate bound to each monomer (Baran et al. 1994; Han et al. 2009; Rossi et al. 2004). The enzyme's cytosolic localization is inferred from that of recombinant protein overexpressed in transfected cells (Perry et al. 1995).

UnificationXref10
type: UnificationXref
id: 3645359
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645359

UnificationXref6502
type: UnificationXref
id: REACT_4966
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4966.2

UnificationXref11
type: UnificationXref
id: DDB0235166
db: Ensembl

UnificationXref6503
type: UnificationXref
id: CHEBI:17813
db: ChEBI

UnificationXref12
type: UnificationXref
id: 3645363
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645363

UnificationXref6500
type: UnificationXref
id: CHEBI:30751
db: ChEBI

UnificationXref13
type: UnificationXref
id: DDB0216749
db: Ensembl

UnificationXref6501
type: UnificationXref
id: 29460
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29460

UnificationXref14
type: UnificationXref
id: 3645367
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645367

UnificationXref6506
type: UnificationXref
id: Q1ZXH9
db: UniProt

UnificationXref15
type: UnificationXref
id: 3645368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645368

UnificationXref6507
type: UnificationXref
id: 3644606
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644606

UnificationXref16
type: UnificationXref
id: 3645369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645369

UnificationXref6504
type: UnificationXref
id: 194644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194644

UnificationXref17
type: UnificationXref
id: 3645370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645370

UnificationXref6505
type: UnificationXref
id: REACT_10253
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10253.1

UnificationXref18
type: UnificationXref
id: 3645371
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645371

UnificationXref19
type: UnificationXref
id: 3645372
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645372

UnificationXref6508
type: UnificationXref
id: 3644608
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644608

UnificationXref6509
type: UnificationXref
id: REACT_92384
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92384.9

Evidence1350
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8444860
xref: http://identifiers.org/pubmed/7744010
xref: http://identifiers.org/pubmed/8352282
comment: Cytosolic pterin-4-alpha-carbinolamine dehydratase (PCDB1) catalyzes the reaction of 4a-hydroxytetrahydrobiopterin to form q-dihydrobiopterin and water (Hauer et al. 1993. The active enzyme is a homotetramer (Ficner et al. 1995); mutations in the PCDB1 gene are associated with mild hyperphenylalanemia in vivo (Citron et al. 1993).

http://identifiers.org/pubmed/22946059
type: PublicationXref
id: 22946059
author: Kunzelmann, Karl
author: Schreiber, Rainer
author: Tian, Yuemin
db: Pubmed
title: Anoctamins are a family of Ca2+ activated Cl- channels
source: J. Cell. Sci.
year: 2012

UniProt:P07829
type: ProteinReference
xref: UnificationXref1323
organism: Dictyostelium discoideum

Evidence1352
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2407
comment: Cytosolic tyrosine aminotransferase (TAT) catalyzes the reversible reaction of tyrosine and alpha-keto (2-oxo) glutarate to form 3-(4-hydroxyphenyl)pyruvate and glutamate (Mitchell et al. 2001). The enzymatic activity of the protein encoded by the cloned human TAT cDNA is inferred from the biochemical properties of its rat homologue. Unpublished crystallographic studies (PDB 3DYD) have shown TAT to be a homodimer with a pyridoxal phosphate moity attached to lysine-280 in each monomer.

UniProt:P07828
type: ProteinReference
xref: UnificationXref1331
organism: Dictyostelium discoideum

Evidence1351
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3033643
xref: http://identifiers.org/pubmed/8262916
comment: Cytosolic dihydropteridine reductase (QDPR) catalyzes the reaction of q-dihydrobiopterin with NADH + H+to form tetrahydrobiopterin and NAD+. The enzyme is a homodimer (Lockyer et al. 1987; Su et al. 1993).

Evidence1354
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10942115
comment: Cytosolic 4-hydroxyphenylpyruvate dioxygenase (HPD) catalyzes the reaction of 3-(4-Hydroxyphenyl)pyruvate with molecular oxygen to form homogentisate and CO2 (Ruetschi et al. 2000). Unpublished crystallographic data indicate that the enzyme is a homodimer (PDB 3ISQ).

Evidence1353
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2407
comment: Cytosolic tyrosine aminotransferase (TAT) catalyzes the reversible reaction of 3-(4-hydroxyphenyl)pyruvate and glutamate to form tyrosine and alpha-keto (2-oxo) glutarate (Mitchell et al. 2001). The enzymatic activity of the protein encoded by the cloned human TAT cDNA is inferred from the biochemical properties of its rat homologue. Unpublished crystallographic studies (PDB 3DYD) have shown TAT to be a homodimer with a pyridoxal phosphate moity attached to lysine-280 in each monomer.

Evidence1356
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11327815
comment: Cytosolic maleylacetoacetic acid isomerase (GSTZ1) catalyzes the conversion of 4-maleylacetoacetate to 4-fumarylacetoacetate. The enzyme is a homodimer (Polekhina et al. 2001).

Evidence1355
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10876237
xref: http://identifiers.org/pubmed/8782815
comment: Cytosolic homogentisate 1,2-dioxygenase (HGD) catalyzes the reaction of homogentisate and molecular oxygen to form 4-maleylacetoacetate. The activity of human HGD is inferred from the phenotype of alkaptonuria patients, in whom HGD activity is defective (Fernandez-Canon et al. 1996). HGD is a homohexamer (Titus et al. 2000).

Evidence1358
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2400
xref: PublicationXref2407
comment: The first reaction in this pathway converts phenylalanine to tyrosine, coupled to the conversion of tetrahydrobiopterin to 4a-hydroxytetrahydrobiopterin, catalyzed by phenylalanine hydroxylase. (Deficiencies in this enzyme are responsible for the commonest form of phenylketonuria (PKU) in humans.) This reaction functions both as the first step in the pathway by which the body disposes of excess phenylalanine, and as a source of the amino acid tyrosine. The next two reactions are responsible for the regeneration of tetrahydrobiopterin from 4a-hydroxytetrahydrobiopterin. The following five reactions convert tyrosine to fumarate, an intermediate in the citric acid cycle, and acetoacetate, a ketone body.

Evidence1357
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8364576
comment: Cytosolic fumarylacetoacetase catalyzes the hydrolysis of 4-fumarylacetoacetate to form fumarate and acetoacetate (Labelle et al. 1993).

Evidence1359
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15662599
comment: The dehydrogenation of proline to L-1-pyrroline-5-carboxylate coupled to the conversion of FAD to FADH2 is the first step in proline breakdown (Bender et al. 2005). Proline dehydrogenase (PRODH), the enzyme that catalyzes this reaction, is found in liver, kidney, and brain cells, where it is tightly bound to the inner mitochondrial membrane.

UniProt:Q55DL0
type: ProteinReference
xref: UnificationXref8435
organism: Dictyostelium discoideum

p(S27)-G protein alpha (z):GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2292
component stoichiometry: Stoichiometry2293
component: SmallMolecule11
component: Protein2522
xref: UnificationXref11225
cellular location: GO:0005886
comment: Reactome DB_ID: 3648196

Evidence1326
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15342248
xref: http://identifiers.org/pubmed/12696021
comment: Mitochondrial 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10; HADH2) catalyzes the reversible reaction of alpha-methylacetoacetyl-CoA and NADH + H+ to form alpha-methyl-beta-hydroxybutyryl-CoA and NAD+ (Ofman et al. 2003). Crystallographic data indicate that the enzyme is a homotetramer (Kissinger et al. 2004).

UnificationXref6553
type: UnificationXref
id: CHEBI:63844
db: ChEBI

Heterotrimeric G-protein Gi (active) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2289
component stoichiometry: Stoichiometry2290
component: G-protein beta-gamma complex (name copied from entity in Homo sapiens)
component: G-protein alpha (i): GTP (name copied from entity in Homo sapiens)
xref: UnificationXref11201
cellular location: GO:0005886
comment: Reactome DB_ID: 3646222

Evidence1327
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17371050
comment: Mitochondrial acetyl-CoA acetyltransferase (ACAT1) catalyzes the reaction of alpha-methyl-acetoacetyl-CoA and CoA to form propionyl-CoA and acetyl-CoA. Structural studies have shown the active enzyme to be a tetramer of ACAT1 polypeptides whose aminoterminal 34 residues, a mitochondrial targeting sequence, have been removed (Haapalainen et al. 2007).

UnificationXref6554
type: UnificationXref
id: 194657
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194657

RhoA,B,C:GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2297
component stoichiometry: Stoichiometry2296
component: SmallMolecule91
component: PhysicalEntity269
xref: UnificationXref11239
cellular location: GO:0005886
comment: Reactome DB_ID: 3646912

Evidence1328
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9889013
xref: http://identifiers.org/pubmed/14752098
xref: http://identifiers.org/pubmed/12359132
comment: Mitochondrial isobutyryl-CoA dehydrogenase (ACAD8) catalyzes the reaction of isobutyryl-CoA and FAD to form methacrylyl-CoA and FADH2 (Roe et al. 1999; Nguyen et al. 2002). Crystallographic studies have shown the active enzyme to be a tetramer of ACAD8 polypeptides whose aminoterminal 23 residues, a mitochondrial targeting sequence, have been removed (Bataille et al. 2004).

UnificationXref6551
type: UnificationXref
id: 194723
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194723

UniProt:P07830
type: ProteinReference
xref: UnificationXref1329
organism: Dictyostelium discoideum

G-protein alpha (z):GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2295
component stoichiometry: Stoichiometry2294
component: SmallMolecule91
component: Protein1094
xref: UnificationXref11229
cellular location: GO:0005886
comment: Reactome DB_ID: 3646781

Evidence1329
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8824301
comment: Mitochondrial 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) catalyzes the hydrolysis of beta-hydroxyisobutyryl-CoA to form beta-hydroxyisobutyrate (3-hydroxy-2-methylpropanoate) and CoA (Hawes et al. 1996).

UnificationXref6552
type: UnificationXref
id: REACT_10930
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10930.1

Evidence1322
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11181649
xref: http://identifiers.org/pubmed/11406611
comment: Methylcrotonyl CoA carboxylase (MCCA) catalyzes the reversible reaction of beta-methylglutaconyl-CoA, ADP, orthophosphate, and H2O to form beta-methylcrotonyl-CoA, ATP, and CO2. Active MCCA is composed of two polypeptides, MCCA1 and MCCA2 (Baumgartner et al. 2001; Holzinger et al. 2001). The enzyme has been purified from fibroblast mitochondria. By analogy to the more thoroughly studied bovine homologue, MCCA is thought to be a hexamer of six MCCA1:MCCA2 dimers, and the MCCA1 polypeptides are thought to have biotin moieties covalently bound to a lysine residue at position 681 in the polypeptide chain. Mitochondrial import of MCCA1 and 2 is associated with removal of aminoterminal mitochondrial targeting sequences but the exact lengths of these sequences have not been determined.

Evidence1323
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11738050
xref: http://identifiers.org/pubmed/3082934
xref: http://identifiers.org/pubmed/12434311
comment: Mitochondrial ethylglutaconyl-CoA hydratase (AUH) catalyzes the hydrolysis of beta-methylglutaconyl-CoA to yield beta-hydroxy-beta-methylglutaryl-CoA (IJlst et al. 2002; Narisawa et al. 1986). Crystallographic studies have shown the active enzyme to be a hexamer of AUH polypeptides whose aminoterminal 67 residues, a mitochondrial targeting sequence, have been removed ((Kurimoto et al. 2001).

UnificationXref6550
type: UnificationXref
id: CHEBI:63841
db: ChEBI

Evidence1324
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11013134
xref: http://identifiers.org/pubmed/10832746
comment: Mitochondrial 2-methyl branched chain acyl-CoA dehydrogenase (ACADSB) catalyzes the reaction of alpha-methylbutyryl-CoA and FAD to form 'tiglyl-CoA and FADH2 (Andresen et al. 2000; Gibson et al. 2000). Unpublished crystallographic data (PDB 2JIF) indicate that the enzyme is a tetramer of ACADSB polypeptides whose aminoterminal 51 residues, a mitochondrial targeting sequence, have been removed.

Evidence1325
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15342248
xref: http://identifiers.org/pubmed/12696021
comment: Mitochondrial 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10; HADH2) catalyzes the reversible reaction of alpha-methyl-beta-hydroxybutyryl-CoA and NAD+ to form alpha-methylacetoacetyl-CoA and NADH + H+ (Ofman et al. 2003). Crystallographic data indicate that the enzyme is a homotetramer (Kissinger et al. 2004).

http://identifiers.org/pubmed/17560368
type: PublicationXref
id: 17560368
author: Peters, L
author: Meister, G
db: Pubmed
title: Argonaute proteins: mediators of RNA silencing
source: Mol Cell 26:611-23
year: 2007

Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2280
component stoichiometry: Stoichiometry2287
component: GABAB receptor:GABA (name copied from entity in Homo sapiens)
component: Heterotrimeric G-protein Gi (inactive) (name copied from entity in Homo sapiens)
xref: UnificationXref11200
cellular location: GO:0005886
comment: Reactome DB_ID: 3646220

Evidence1320
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9214289
xref: http://identifiers.org/pubmed/6928646
xref: http://identifiers.org/pubmed/3597357
comment: Mitochondrial isovaleryl dehydrogenase (IVD) catalyzes the reaction of isovaleryl-CoA and FAD to form beta-methylcrotonyl-CoA and FADH2 (Finocchiaro et al. 1978; Rhead and Tanaka 1980). Crystallographic studies demonstrated the existene of a tetramer of IVD polypeptides lacking an aminoterminal mitochondrial targeting sequence (Tiffany et al. 1997).

G-protein alpha (z):GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2277
component stoichiometry: Stoichiometry2278
component: SmallMolecule11
component: Protein1094
xref: UnificationXref11189
cellular location: GO:0005886
comment: Reactome DB_ID: 3646773

Evidence1321
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7356336
xref: http://identifiers.org/pubmed/11181649
xref: http://identifiers.org/pubmed/11406611
xref: http://identifiers.org/pubmed/16023992
comment: Methylcrotonyl CoA carboxylase (MCCA) catalyzes the reversible reaction of beta-methylcrotonyl-CoA, ATP, and CO2 to form beta-methylglutaconyl-CoA, ADP, orthophosphate, and H2O. Active MCCA is composed of two polypeptides, MCCA1 and MCCA2 (Baumgartner et al. 2001; Holzinger et al. 2001). The enzyme has been purified from fibroblast mitochondria. By analogy to the more thoroughly studied bovine homologue, MCCA is thought to be a hexamer of six MCCA1:MCCA2 dimers, and the MCCA1 polypeptide is thought to have a biotin moiety covalently bound to lysine residue 681. Localization of the complex to the mitochondrial inner membrane is inferred from studies of the bovine homologue (Hector et al. 1980). Mitochondrial import of MCCA1 and 2 is associated with removal of aminoterminal mitochondrial targeting sequences (Stadler et al. 2005).

Ensembl:DDB0304755
type: ProteinReference
xref: UnificationXref6837
organism: Dictyostelium discoideum

G-protein alpha (i):GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2282
component stoichiometry: Stoichiometry2281
component: SmallMolecule91
component: PhysicalEntity144
xref: UnificationXref11193
cellular location: GO:0005886
comment: Reactome DB_ID: 3646211

Heterotrimeric G-protein Gi (inactive) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2286
component stoichiometry: Stoichiometry2283
component: G-protein beta-gamma complex (name copied from entity in Homo sapiens)
component: G-protein alpha (i):GDP (name copied from entity in Homo sapiens)
xref: UnificationXref11199
cellular location: GO:0005886
comment: Reactome DB_ID: 3646219

Ensembl:DDB0217387
type: ProteinReference
xref: UnificationXref6856
organism: Dictyostelium discoideum

Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2291
component stoichiometry: Stoichiometry2288
component: GABAB receptor:GABA (name copied from entity in Homo sapiens)
component: Heterotrimeric G-protein Gi (active) (name copied from entity in Homo sapiens)
xref: UnificationXref11202
cellular location: GO:0005886
comment: Reactome DB_ID: 3646223

Ensembl:DDB0168012
type: ProteinReference
xref: UnificationXref6858
organism: Dictyostelium discoideum

G-protein beta-gamma complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2284
component stoichiometry: Stoichiometry2285
component: PhysicalEntity267
component: Protein2510
xref: UnificationXref11198
cellular location: GO:0005886
comment: Reactome DB_ID: 3646218

ROS
type: SmallMoleculeReference
name: Reactive oxygen species
name: Reactive oxygen species [ChEBI:26523]
xref: UnificationXref1161

Ensembl:DDB0252759
type: ProteinReference
xref: UnificationXref6813
organism: Dictyostelium discoideum

Ensembl:DDB0184541
type: ProteinReference
xref: UnificationXref6815
organism: Dictyostelium discoideum

UnificationXref6559
type: UnificationXref
id: 194661
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194661

UnificationXref6558
type: UnificationXref
id: CHEBI:52386
db: ChEBI

UnificationXref6557
type: UnificationXref
id: REACT_91114
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91114.9

UnificationXref6556
type: UnificationXref
id: 3644596
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644596

UnificationXref6555
type: UnificationXref
id: REACT_10167
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10167.1

http://identifiers.org/pubmed/6311078
type: PublicationXref
id: 6311078
author: Hammarström, Sven
db: Pubmed
title: Leukotrienes
source: Annu Rev Biochem 52:355-77
year: 1983

UniProt:Q55DR6
type: ProteinReference
xref: UnificationXref5936
organism: Dictyostelium discoideum

RhoGTPase:GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2273
component stoichiometry: Stoichiometry2272
component: PhysicalEntity266
component: SmallMolecule2
xref: UnificationXref11171
cellular location: GO:0005829
comment: Reactome DB_ID: 3644674

Evidence1339
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10775527
xref: http://identifiers.org/pubmed/6434529
comment: The saccharopine dehydrogenase activity of lysine-ketoglutarate reductase / saccharopine dehydrogenase homotetramer in the mitochondrial matrix catalyzes the reaction of lysine, alpha-ketoglutarate, and NADPH + H+ to form saccharopine, NADP+, and H2O (Markovitz et al. 1984; Sacksteder et al. 2001).

UnificationXref6562
type: UnificationXref
id: REACT_154030
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154030.3

Inactivated RhoGTPase:GDP:GDI complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2275
component stoichiometry: Stoichiometry2274
component: RhoGTPase:GDP (name copied from entity in Homo sapiens)
component: Protein2486
xref: UnificationXref11172
cellular location: GO:0005829
comment: Reactome DB_ID: 3644675

UnificationXref6563
type: UnificationXref
id: CHEBI:18252
db: ChEBI

RhoGTPase:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2270
component stoichiometry: Stoichiometry2271
component: SmallMolecule11
component: PhysicalEntity264
xref: UnificationXref11043
cellular location: GO:0005886
comment: Reactome DB_ID: 3644677

Evidence1337
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10773664
xref: http://identifiers.org/pubmed/7901203
xref: http://identifiers.org/pubmed/12815595
comment: Cytosolic formimidoyltransferase-cyclodeaminase (FTCD) catalyzes the reaction of N-formiminoglutamate and tetrahydrofolate to form glutamate and 5-formiminotetrahydrofolate. The gene encoding the human enzyme has beeen cloned and its sequence can encode a protein homologous the the biochemically characterized porcine protein (Solans et al. 2000; Murley et al. 1993). The function of FTCD in vivo was established by identification of missense mutations that reduce enzyme activity in patients with glutamate formiminotransferase deficiency (Hilton et al. 2003). Human FTCD is inferred to be an octamer by homology to the porcine enzyme (Murley et al. 1993).

UnificationXref6564
type: UnificationXref
id: 194691
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194691

UniProt:Q55E35
type: ProteinReference
xref: UnificationXref12207
organism: Dictyostelium discoideum

RhoGTPase:GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2269
component stoichiometry: Stoichiometry2268
component: SmallMolecule91
component: PhysicalEntity264
xref: UnificationXref11042
cellular location: GO:0005886
comment: Reactome DB_ID: 3644642

Evidence1338
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/5057083
comment: The major pathway of histidine catabolism, annotated here, proceeds in four steps to yield glutamate and, in the process, convert one molecule of tetrahydrofolate to 5-formiminotetrahydrofolate (Morris et al. 1972). Histidine can also be decarboxylated to form histamine.

UnificationXref6565
type: UnificationXref
id: REACT_10642
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10642.2

UniProt:Q55E32
type: ProteinReference
xref: UnificationXref6569
organism: Dictyostelium discoideum

UniProt:Q55DR2
type: ProteinReference
xref: UnificationXref128
organism: Dictyostelium discoideum

Evidence1335
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15221005
xref: http://identifiers.org/pubmed/19304569
comment: Cytosolic urocanate hydratase (UROC1) catalyzes the hydrolysis of urocanate to form 4-imidazolone-5-propanoate. Human UROC1 was first identified in surveys of genes differentially expressed in hepatoblastoma (Yamamda et al. 2004). Recent biochemical and molecular studies of UROC1 protein and cDNA from a patient with urocanic aciduria has confirmed the function of UROC1 in vivo (Espinos et al. 2009).

Evidence1336
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15221005
comment: Cytosolic imidazolonepropionase catalyzes the hydrolysis of 4-imidazolone-5-propanoate to form N-Formimino-L-glutamate. While evidence from many experimental systems indicates that this reaction occurs, existence of the human enzyme is inferred only from high-throughput screening studies (e.g., Yamada et al. 2004).

http://identifiers.org/pubmed/8892014
type: PublicationXref
id: 8892014
author: Treacy, E
author: Thompson, GN
author: Pitt, JJ
author: Cotton, RG
author: Seller, K
author: Ramus, S
db: Pubmed
title: In vivo disposal of phenylalanine in phenylketonuria: a study of two siblings
source: J Inherit Metab Dis 19:595-602
year: 1996

Evidence1333
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2380
xref: PublicationXref2356
comment: The branched-chain amino acids, leucine, isoleucine, and valine, are all essential amino acids (i.e., ones required in the diet). They are major constituents of muscle protein. The breakdown of these amino acids starts with two common steps catalyzed by enzymes that act on all three amino acids: reversible transamination by branched-chain amino acid aminotransferase, and irreversible oxidative decarboxylation by the branched-chain ketoacid dehydrogenase complex. Isovaleryl-CoA is produced from leucine by these two reactions, alpha-methylbutyryl-CoA from isoleucine, and isobutyryl-CoA from valine. These acyl-CoA's undergo dehydrogenation, catalyzed by three different but related enzymes, and the breakdown pathways then diverge. Leucine is ultimately converted to acetyl-CoA and acetoacetate; isoleucine to acetyl-CoA and succinyl-CoA; and valine to succinyl-CoA. Under fasting conditions, substantial amounts of all three amino acids are generated by protein breakdown. In muscle, the final products of leucine, isoleucine, and valine catabolism can be fully oxidized via the citric acid cycle; in liver they can be directed toward the synthesis of ketone bodies (acetoacetate and acetyl-CoA) and glucose (succinyl-CoA) (Chuang & Shih 2001, Sweetman & Williams 2001).

UnificationXref6560
type: UnificationXref
id: REACT_10977
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10977.1

G-protein alpha (z):GTP:Adenylate cyclase (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2279
component stoichiometry: Stoichiometry2276
component: G-protein alpha (z):GTP (name copied from entity in Homo sapiens)
component: Adenylate cyclase (Mg2+ cofactor) (name copied from entity in Homo sapiens)
xref: UnificationXref11190
cellular location: GO:0005886
comment: Reactome DB_ID: 3646774

Evidence1334
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15806399
comment: Cytosolic histidine ammonia lyase (HAL) catalyzes the reaction of histidine to form urocanate and NH4+ (Kawai et al. 2005).

UnificationXref6561
type: UnificationXref
id: 3644612
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644612

PIP3:PDK1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2257
component stoichiometry: Stoichiometry2256
component: SmallMolecule1140
component: Protein149
xref: UnificationXref10939
cellular location: GO:0005886
comment: Reactome DB_ID: 3642768

Evidence1331
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/13416257
comment: Mitochondrial 3-hydroxyisobutyrate dehydrogenase (HIBADH) catalyzes the reversible reaction of methylmalonyl semialdehyde and NADH + H+ to form beta-hydroxyisobutyrate and NAD+. The biochemical properties of human HIBADH are inferred from those of its better-studied porcine homologue (Robinson and Coon 1957). Unpublished crystallographic studies (PDB 2GF2) have shown the active enzyme to be a tetramer of HIBADH polypeptides whose aminoterminal 40 residues, a mitochondrial targeting sequence, have been removed.

Evidence1332
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10947204
xref: http://identifiers.org/pubmed/1527093
comment: Mitochondrial methylmalonate semialdehyde dehydrogenase (ALDH6A1) catalyzes the reaction of methylmalonate semialdehyde, NAD+, and CoA to form propionyl-CoA, CO2, and NADH + H+. A human ALDH6A1 gene has been cloned. Its sequence is closely homologous to that of the better-characterized rat enzyme (Kedishvili et al. 1992) and a missense mutation in a normally well-conserved codon has been found in the allele of the gene from a patient with a defect in methylmalonic semialdehyde dehydrogenase activity (Chambliss et al. 2000).

Evidence1330
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/13416257
comment: Mitochondrial 3-hydroxyisobutyrate dehydrogenase (HIBADH) catalyzes the reversible reaction of beta-hydroxyisobutyrate and NAD+ to form methylmalonyl semialdehyde and NADH + H+. The biochemical properties of human HIBADH are inferred from those of its better-studied porcine homologue (Robinson and Coon 1957). Unpublished crystallographic studies (PDB 2GF2) have shown the active enzyme to be a tetramer of HIBADH polypeptides whose aminoterminal 40 residues, a mitochondrial targeting sequence, have been removed.

Ub-RNF41 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2267
component stoichiometry: Stoichiometry2266
component: Protein2396
component: Protein217
xref: UnificationXref11007
cellular location: GO:0005829
comment: Reactome DB_ID: 3649385

PIP3:RhoA (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2265
component stoichiometry: Stoichiometry2264
component: SmallMolecule1140
component: Protein2393
xref: UnificationXref10986
cellular location: GO:0005886
comment: Reactome DB_ID: 3645321

RAC1:GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2263
component stoichiometry: Stoichiometry2262
component: SmallMolecule91
component: Protein117
xref: UnificationXref10962
cellular location: GO:0005886
comment: Reactome DB_ID: 3645460

Ensembl:DDB0219574
type: ProteinReference
xref: UnificationXref7081
organism: Dictyostelium discoideum

PIP3:AKT2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2259
component stoichiometry: Stoichiometry2258
component: SmallMolecule1140
component: Protein2387
xref: UnificationXref10943
cellular location: GO:0005886
comment: Reactome DB_ID: 3642774

Ensembl:DDB0231750
type: ProteinReference
xref: UnificationXref6881
organism: Dictyostelium discoideum

UnificationXref6567
type: UnificationXref
id: 195691
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=195691

UnificationXref6566
type: UnificationXref
id: CHEBI:16290
db: ChEBI

UnificationXref6569
type: UnificationXref
id: Q55E32
db: UniProt

UnificationXref6568
type: UnificationXref
id: REACT_10447
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10447.1

p-AMPK heterotrimer:AMP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2252
component stoichiometry: Stoichiometry2253
component: p-AMPK heterotrimer (name copied from entity in Homo sapiens)
component: SmallMolecule8
xref: UnificationXref10922
cellular location: GO:0005829
comment: Reactome DB_ID: 3646333

Evidence1300
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11863375
xref: http://identifiers.org/pubmed/19360321
comment: Glutamic-pyruvate transaminase 2 (alanine aminotransferase 2) (GPT2) catalyzes the reversible reaction of alanine and 2-oxoglutarate (alpha-ketoglutarate) to form pyruvate and glutamate (Yang et al. 2002). Unpublished crystallographic data are consistent with a homodimeric structure for the enzyme with one molecule of pyridoxal phosphate associated with each monomer (PDB 3IHJ). Recent studies of organelles purified from cultured human muscle cells suggest that GPT2 is localized to mitochondria (Glinghammar et al. 2009).

UniProt:Q55DQ0
type: ProteinReference
xref: UnificationXref7621
organism: Dictyostelium discoideum

p-AMPK heterotrimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2251
component stoichiometry: Stoichiometry2250
component stoichiometry: Stoichiometry2249
component: Protein2384
component: Protein90
component: Protein93
xref: UnificationXref10921
cellular location: GO:0005829
comment: Reactome DB_ID: 3645171

Evidence1301
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11863375
xref: http://identifiers.org/pubmed/19360321
comment: Glutamic-pyruvate transaminase 2 (alanine aminotransferase 2) (GPT2) catalyzes the reversible reaction of pyruvate and glutamate to form alanine and 2-oxoglutarate (alpha-ketoglutarate) (Yang et al. 2002). Unpublished crystallographic data are consistent with a homodimeric structure for the enzyme with one molecule of pyridoxal phosphate associated with each monomer (PDB 3IHJ). Recent studies of organelles purified from cultured human muscle cells suggest that GPT2 is localized to mitochondria (Glinghammar et al. 2009).

UniProt:Q55E21
type: ProteinReference
xref: UnificationXref10789
organism: Dictyostelium discoideum

Evidence1302
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2241899
comment: Cytosolic aspartate aminotransferase (glutamate oxaloacetate transaminase 1 - GOT1) catalyzes the reversible reaction of oxaloacetate and glutamate to form aspartate and 2-oxoglutarate (alpha-ketoglutarate) (Doyle et al. 1990). Unpublished crystallographic data (PBD 3IIO) suggest the enzyme is a homodimer.

http://identifiers.org/pubmed/8102790
type: PublicationXref
id: 8102790
author: Bergeron, JJ
author: Cameron, PH
author: Thomas, DY
author: Ou, WJ
db: Pubmed
title: Association of folding intermediates of glycoproteins with calnexin during protein maturation
source: Nature 364:771-6
year: 1993

Evidence1303
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4052435
comment: Mitochondrial glutamate oxaloacetate transaminase 2 (aspartate aminotransferase 2 - GOT2) catalyzes the reversible reaction of aspartate and 2-oxoglutarate (alpha-ketoglutarate) to form oxaloacetate and glutamate (Martini et al. 1985). The active form of the enzyme is inferred to be a dimer with one molecule of pyridoxal phosphate associated with each monomer.

Activated mTORC1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2237
component stoichiometry: Stoichiometry2236
component stoichiometry: Stoichiometry2238
component stoichiometry: Stoichiometry2235
component: Rheb:GTP (name copied from entity in Homo sapiens)
component: Protein162
component: Protein160
component: Protein2366
xref: UnificationXref10872
cellular location: GO:0005829
comment: Reactome DB_ID: 3643712

Evidence1304
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9514741
xref: http://identifiers.org/pubmed/6819292
xref: http://identifiers.org/pubmed/1737786
xref: PublicationXref2336
comment: Mitochondrial ornithine aminotransferase (OAT) catalyzes the reversible reaction of ornithine and alpha-ketoglutarate to form glutamate semialdehyde and glutamate (Ohura et al. 1982). The active enzyme is a hexamer (Shen et al. 1998). Inherited OAT deficiency leads to ornithine accumulation in vivo and gyrate atrophy of the choroid and retina (Brody et al. 1992; Valle and Simell 2001).

UnificationXref6531
type: UnificationXref
id: CHEBI:63842
db: ChEBI

Rheb:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2233
component stoichiometry: Stoichiometry2234
component: SmallMolecule1
component: Protein2365
xref: UnificationXref10867
cellular location: GO:0005829
comment: Reactome DB_ID: 3643698

Evidence1305
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1737786
xref: PublicationXref2336
comment: Mitochondrial ornithine aminotransferase (OAT) catalyzes the reversible reaction of glutamate semialdehyde and glutamate to form ornithine and alpha-ketoglutarate (Ohura et al. 1982). The active enzyme is a hexamer (Shen et al. 1998). Inherited OAT deficiency leads to ornithine accumulation in vivo and gyrate atrophy of the choroid and retina (Brody et al. 1992; Vallee and Simell 2001).

UnificationXref6532
type: UnificationXref
id: 194735
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194735

eIF4E:4E-BP1-P (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2247
component stoichiometry: Stoichiometry2248
component: Protein2382
component: Protein2383
xref: UnificationXref10910
cellular location: GO:0005829
comment: Reactome DB_ID: 3643717

Evidence1306
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2564390
comment: Cytosolic asparagine synthase (ASNS) catalyzes the reaction of aspartate, glutamine, and ATP to form asparagine, glutamate, AMP, and pyrophosphate. Studies of the recombinant protein expressed in E. coli suggest that the active form of the enzyme is a dimer (Van Heeke and Schuster 1989).

eIF4E:4E-BP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2243
component stoichiometry: Stoichiometry2244
component: Protein2382
component: Protein2381
xref: UnificationXref10908
cellular location: GO:0005829
comment: Reactome DB_ID: 3641537

Evidence1307
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11903050
xref: http://identifiers.org/pubmed/12054821
xref: http://identifiers.org/pubmed/429360
comment: Mitochondrial glutamate dehydrogenase 1 (GLUD1) catalyzes the reversible reaction of 2-oxoglutarate, NAD(P)H + H+, and ammonia to form glutamate and NAD(P)+ (Fang et al. 2002). Mature GLUD1 protein lacks the 53 aminoterminal residues of the nascent protein (Julliard and Smith 1979), which function as a mitochondrial import signal. The active form of the enzyme is a hexamer, allosterically activated by ADP and inhibited by GTP (Fang et al. 2002; Smith et al. 2002).

UnificationXref6530
type: UnificationXref
id: REACT_153911
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153911.3

UPF1:eRF3 Complex on Translated mRNA (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2228
component stoichiometry: Stoichiometry2229
component: Protein2268
component: Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction (name copied from entity in Homo sapiens)
xref: UnificationXref10818
cellular location: GO:0005829
comment: Reactome DB_ID: 3648655

mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2224
component stoichiometry: Stoichiometry2223
component stoichiometry: Stoichiometry2222
component stoichiometry: Stoichiometry2221
component: PhysicalEntity252
component: Protein2269
component: Cap Binding Complex (CBC) (name copied from entity in Homo sapiens)
component: PhysicalEntity263
xref: UnificationXref10816
cellular location: GO:0005829
comment: Reactome DB_ID: 3648653

Rheb:GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2231
component stoichiometry: Stoichiometry2232
component: SmallMolecule2
component: Protein2365
xref: UnificationXref10866
cellular location: GO:0005829
comment: Reactome DB_ID: 3643697

Slo3 Channel (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2230
component: Protein2364
xref: UnificationXref10841
cellular location: GO:0005886
comment: Reactome DB_ID: 3651322

3beta-Hydroxyandrost-5-en-17-one
type: SmallMoleculeReference
name: Dehydroepiandrosterone [ChEBI:28689]
name: DHEA
name: Dehydroisoandrosterone
name: Dehydroepiandrosterone
name: DHA
xref: UnificationXref2465

http://identifiers.org/pubmed/9207117
type: PublicationXref
id: 9207117
author: Zhou, B
author: Gitschier, J
db: Pubmed
title: hCTR1: a human gene for copper uptake identified by complementation in yeast
source: Proc Natl Acad Sci U S A 94:7481-6
year: 1997

Ensembl:DDB0188326
type: ProteinReference
xref: UnificationXref7124
organism: Dictyostelium discoideum

Ensembl:DDB0234213
type: ProteinReference
xref: UnificationXref7137
organism: Dictyostelium discoideum

Ensembl:DDB0205575
type: ProteinReference
xref: UnificationXref7126
organism: Dictyostelium discoideum

Evidence1309
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7883047
xref: http://identifiers.org/pubmed/15364907
xref: http://identifiers.org/pubmed/19338303
xref: http://identifiers.org/pubmed/8294935
comment: CCBL1 (KAT 1) catalyzes the reaction of glutamine and pyruvate to form 2-oxoglutaramate and alanine. The active form of CCBL1 is a homodimer with one molecule of pyridoxal phosphate bound to each monomer (Baran et al. 1994; Han et al. 2009; Rossi et al. 2004). The enzyme's cytosolic localization is inferred from that of recombinant protein overexpressed in transfected cells (Perry et al. 1995).

UnificationXref6536
type: UnificationXref
id: DDB0302376
db: Ensembl

Evidence1308
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11903050
xref: http://identifiers.org/pubmed/12054821
xref: http://identifiers.org/pubmed/429360
comment: Mitochondrial glutamate dehydrogenase 1 (GLUD1) catalyzes the reversible reaction of glutamate and NAD(P)+ to form 2-oxoglutarate, NAD(P)H + H+, and ammonia (Fang et al. 2002). Mature GLUD1 protein lacks the 53 aminoterminal residues of the nascent protein (Julliard and Smith 1979), which function as a mitochondrial import signal. The active form of the enzyme is a hexamer, allosterically activated by ADP and inhibited by GTP (Fang et al. 2002; Smith et al. 2002).

UnificationXref6535
type: UnificationXref
id: 3644578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644578

UnificationXref6534
type: UnificationXref
id: Q55D52
db: UniProt

http://identifiers.org/pubmed/14609716
type: PublicationXref
id: 14609716
author: Karlsson, A
author: Johansson, M
author: Van Rompay, AR
db: Pubmed
title: Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
source: Pharmacol Ther 100:119-139
year: 2003

UnificationXref6533
type: UnificationXref
id: REACT_10298
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10298.1

UnificationXref6539
type: UnificationXref
id: 3644586
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644586

UnificationXref6538
type: UnificationXref
id: Q55D54
db: UniProt

UnificationXref6537
type: UnificationXref
id: 3644582
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644582

Evidence1313
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15021249
comment: L-Serine is needed in human brain in large amounts as precursor to important biomolecules such as nucleotides, phospholipids and the neurotransmitters glycine and D-serine. The pathway for its synthesis starts with 3-phosphoglycerate and it later needs glutamate as an amination agent. Deficiencies in the participating enzymes lead to severe neurological symptoms that are treatable with serine if treatment starts early (de Koning & Klomp 2004).

Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2225
component stoichiometry: Stoichiometry2219
component stoichiometry: Stoichiometry2227
component stoichiometry: Stoichiometry2226
component stoichiometry: Stoichiometry2220
component: GDP bound eRF3 (name copied from entity in Homo sapiens)
component: 80S ribosome (name copied from entity in Homo sapiens)
component: mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction (name copied from entity in Homo sapiens)
component: SmallMolecule1138
component: Protein2272
xref: UnificationXref10817
cellular location: GO:0005829
comment: Reactome DB_ID: 3648654

Evidence1314
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: These reactions mediate the synthesis of aspartate, asparagine, glutamate, and glutamine from ammonia and intermediates of glycolysis, and allow the utilization of the carbon atoms from these four amino acids for glucose synthesis under fasting conditions. These reactions also provide a means to collect nitrogen, both as ammonia and as amino groups, and direct it towards urea synthesis. Transamination, the conversion of an amino acid to the corresponding alpha-keto acid coupled to the conversion of a molecule of alpha-ketoglutarate to glutamate, is the first step in the catabolism of most amino acids. Transamination reactions are freely reversible so they also provide a means to balance concentrations of various amino acids and alpha-keto (2-oxo) acids in the cytosol.

http://identifiers.org/pubmed/12627223
type: PublicationXref
id: 12627223
author: Miyano, M
author: Irikura, Daisuke
author: Matsumura, H
author: Kumasaka, T
author: Kai, Y
author: Uodome, N
author: Urade, Y
author: Yamamoto, M
author: Inoue, T
author: Kinugasa, S
author: Okazaki, N
db: Pubmed
title: Mechanism of metal activation of human hematopoietic prostaglandin D synthase
source: Nat Struct Biol 10:291-6
year: 2003

SMG1:Phosphorylated UPF1:EJC:Translated mRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2218
component stoichiometry: Stoichiometry2217
component stoichiometry: Stoichiometry2216
component: Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction (name copied from entity in Homo sapiens)
component: SMG1:SMG8:SMG9 Complex (name copied from entity in Homo sapiens)
component: Protein2362
xref: UnificationXref10809
cellular location: GO:0005829
comment: Reactome DB_ID: 3648692

Evidence1311
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12633500
comment: The amino group needed for serine biosynthesis comes from glutamate. Its transfer onto 3-phosphonooxpyruvate is catalysed by the PSAT1 dimer which needs pyridoxal phosphate as cofactor. (Baek et al. 2003)

SMG1:SMG8:SMG9 Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2211
component stoichiometry: Stoichiometry2212
component stoichiometry: Stoichiometry2210
component: PhysicalEntity262
component: Protein2361
component: PhysicalEntity261
xref: UnificationXref10806
cellular location: GO:0005829
comment: Reactome DB_ID: 3648690

Evidence1312
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9188776
comment: Dephosphorylation of O-phospho-L-serine to L-serine proceeds through a phospho-enzyme intermediate of the catalysing phosphatase PSP (Collet et al. 1997).

Magoh-Y14 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2201
component stoichiometry: Stoichiometry2200
component: Protein2358
component: Protein2357
xref: UnificationXref10793
cellular location: GO:0005829
comment: Reactome DB_ID: 3642345

Evidence1317
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9165094
xref: http://identifiers.org/pubmed/12269802
xref: http://identifiers.org/pubmed/11264579
comment: Mitochondrial branched-chain-amino-acid aminotransferase (BCAT2) catalyzes the reversible reactions of leucine, isoleucine, or valine with alpha-ketoglutarate (2-oxoglutarate) to form alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate, respectively, and glutamate (Bledsoe et al. 1997). The active enzyme is a homodimer (Yennawar et al. 2001, 2002). In the body, this enzyme is widely expressed but is especially abundant in muscle tissue.

UnificationXref6540
type: UnificationXref
id: 3644587
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644587

Core Exon Junction Complex (Core EJC) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2199
component stoichiometry: Stoichiometry2203
component stoichiometry: Stoichiometry2202
component: Magoh-Y14 complex (name copied from entity in Homo sapiens)
component: Protein2356
component: PhysicalEntity259
xref: UnificationXref10795
cellular location: GO:0005829
comment: Reactome DB_ID: 3648668

Evidence1318
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9165094
xref: http://identifiers.org/pubmed/12269802
xref: http://identifiers.org/pubmed/11264579
comment: Mitochondrial branched-chain-amino-acid aminotransferase (BCAT2) catalyzes the reversible reactions of alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate with glutamate to form leucine, isoleucine, or valine, respectively, and alpha-ketoglutarate (Bledsoe et al. 1997). The active enzyme is a homodimer (Yennawar et al. 2001, 2002). In the body, this enzyme is widely expressed but is especially abundant in muscle tissue.

UnificationXref6541
type: UnificationXref
id: 3644589
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644589

Exon Junction:UPF2:UPF3 Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2205
component stoichiometry: Stoichiometry2206
component stoichiometry: Stoichiometry2204
component stoichiometry: Stoichiometry2207
component: Protein2359
component: Protein2360
component: Core Exon Junction Complex (Core EJC) (name copied from entity in Homo sapiens)
component: PhysicalEntity260
xref: UnificationXref10800
cellular location: GO:0005829
comment: Reactome DB_ID: 3648674

Evidence1315
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16141215
comment: Cytosolic branched-chain-amino-acid aminotransferase (BCAT1) catalyzes the reversible reactions of leucine, isoleucine, or valine with alpha-ketoglutarate (2-oxoglutarate) to form alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate, respectively, and glutamate. The active enzyme is a homodimer. Hutson and colleagues have argues that cytosolic BCAT1 plays a major role in the generation of glutamate involved in synaptic transmission in neural tissue (Goto et al. 2005).

UnificationXref6542
type: UnificationXref
id: REACT_106654
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106654.9

GDP bound eRF3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2196
component stoichiometry: Stoichiometry2197
component: SmallMolecule2
component: Protein2355
xref: UnificationXref10786
cellular location: GO:0005829
comment: Reactome DB_ID: 3643416

Evidence1316
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16141215
comment: Cytosolic branched-chain-amino-acid aminotransferase (BCAT1) catalyzes the reversible reactions of alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate with glutamate to form leucine, isoleucine, or valine, respectively, and alpha-ketoglutarate (2-oxoglutarate). The active enzyme is a homodimer (Goto et al. 2005).

UnificationXref6543
type: UnificationXref
id: CHEBI:50593
db: ChEBI

40S ribosomal complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2170
component stoichiometry: Stoichiometry2193
component stoichiometry: Stoichiometry2191
component stoichiometry: Stoichiometry2175
component stoichiometry: Stoichiometry2187
component stoichiometry: Stoichiometry2162
component stoichiometry: Stoichiometry2169
component stoichiometry: Stoichiometry2161
component stoichiometry: Stoichiometry2176
component stoichiometry: Stoichiometry2167
component stoichiometry: Stoichiometry2171
component stoichiometry: Stoichiometry2166
component stoichiometry: Stoichiometry2180
component stoichiometry: Stoichiometry2174
component stoichiometry: Stoichiometry2192
component stoichiometry: Stoichiometry2173
component stoichiometry: Stoichiometry2177
component stoichiometry: Stoichiometry2164
component stoichiometry: Stoichiometry2178
component stoichiometry: Stoichiometry2190
component stoichiometry: Stoichiometry2182
component stoichiometry: Stoichiometry2179
component stoichiometry: Stoichiometry2185
component stoichiometry: Stoichiometry2188
component stoichiometry: Stoichiometry2184
component stoichiometry: Stoichiometry2168
component stoichiometry: Stoichiometry2181
component stoichiometry: Stoichiometry2172
component stoichiometry: Stoichiometry2163
component stoichiometry: Stoichiometry2183
component stoichiometry: Stoichiometry2186
component stoichiometry: Stoichiometry2165
component stoichiometry: Stoichiometry2189
component: Protein2333
component: Protein2330
component: Protein2337
component: Protein2341
component: Protein2340
component: Protein2339
component: Protein2336
component: Protein2343
component: Protein2354
component: Protein2329
component: Protein2324
component: Protein2323
component: Protein2351
component: Protein2328
component: Protein2342
component: Protein2345
component: PhysicalEntity258
component: Protein2325
component: Protein2349
component: Protein2350
component: Protein2338
component: Protein2344
component: Protein2331
component: Protein2346
component: Protein2335
component: Protein2348
component: Protein2352
component: Protein2327
component: Protein2326
component: Protein2347
component: Protein2353
component: Protein2334
component: Protein2332
xref: UnificationXref10782
cellular location: GO:0005829
comment: Reactome DB_ID: 3641452

60S ribosomal complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2155
component stoichiometry: Stoichiometry2135
component stoichiometry: Stoichiometry2158
component stoichiometry: Stoichiometry2153
component stoichiometry: Stoichiometry2133
component stoichiometry: Stoichiometry2110
component stoichiometry: Stoichiometry2156
component stoichiometry: Stoichiometry2114
component stoichiometry: Stoichiometry2141
component stoichiometry: Stoichiometry2154
component stoichiometry: Stoichiometry2142
component stoichiometry: Stoichiometry2119
component stoichiometry: Stoichiometry2144
component stoichiometry: Stoichiometry2143
component stoichiometry: Stoichiometry2136
component stoichiometry: Stoichiometry2147
component stoichiometry: Stoichiometry2139
component stoichiometry: Stoichiometry2159
component stoichiometry: Stoichiometry2127
component stoichiometry: Stoichiometry2125
component stoichiometry: Stoichiometry2115
component stoichiometry: Stoichiometry2112
component stoichiometry: Stoichiometry2116
component stoichiometry: Stoichiometry2121
component stoichiometry: Stoichiometry2132
component stoichiometry: Stoichiometry2120
component stoichiometry: Stoichiometry2149
component stoichiometry: Stoichiometry2151
component stoichiometry: Stoichiometry2130
component stoichiometry: Stoichiometry2129
component stoichiometry: Stoichiometry2123
component stoichiometry: Stoichiometry2126
component stoichiometry: Stoichiometry2111
component stoichiometry: Stoichiometry2113
component stoichiometry: Stoichiometry2138
component stoichiometry: Stoichiometry2109
component stoichiometry: Stoichiometry2134
component stoichiometry: Stoichiometry2128
component stoichiometry: Stoichiometry2150
component stoichiometry: Stoichiometry2122
component stoichiometry: Stoichiometry2140
component stoichiometry: Stoichiometry2137
component stoichiometry: Stoichiometry2152
component stoichiometry: Stoichiometry2131
component stoichiometry: Stoichiometry2118
component stoichiometry: Stoichiometry2148
component stoichiometry: Stoichiometry2108
component stoichiometry: Stoichiometry2145
component stoichiometry: Stoichiometry2157
component stoichiometry: Stoichiometry2124
component stoichiometry: Stoichiometry2146
component stoichiometry: Stoichiometry2117
component: Protein2274
component: Protein2304
component: Protein2285
component: Protein2291
component: Protein2296
component: Protein2282
component: Protein2283
component: Protein2305
component: Protein2318
component: Protein2293
component: PhysicalEntity257
component: Protein2300
component: Protein2302
component: Protein2278
component: PhysicalEntity255
component: Protein2299
component: Protein2284
component: Protein2295
component: PhysicalEntity256
component: Protein2313
component: Protein2320
component: Protein2279
component: Protein2289
component: Protein2287
component: Protein2288
component: Protein2292

80S ribosome (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2194
component stoichiometry: Stoichiometry2160
component: 60S ribosomal complex (name copied from entity in Homo sapiens)
component: 40S ribosomal complex (name copied from entity in Homo sapiens)
xref: UnificationXref10783
cellular location: GO:0005829
comment: Reactome DB_ID: 3641760

Evidence1310
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19235232
comment: Serine biosynthesis starts from 3-phosphoglycerate, a glycolysis intermediate. Its dehydrogenation is catalysed by tetrameric phosphoglycerate dehydrogenase PHGDH. (Tabatabaie et al. 2009).

long-chain fatty acid anion
type: SmallMoleculeReference
name: long-chain fatty acid anion [ChEBI:57560]
xref: UnificationXref6829

Ensembl:DDB0219484
type: ProteinReference
xref: UnificationXref7203
organism: Dictyostelium discoideum

RNA Polymerase III Transcription Initiation
type: Pathway
data source: Provenance1
pathway component: REACT 29496.10
evidence: Evidence1770
xref: UnificationXref12004
xref: UnificationXref12003
pathway order: PathwayStep1738
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref6545
type: UnificationXref
id: REACT_10464
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10464.1

UnificationXref6544
type: UnificationXref
id: 194667
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194667

UnificationXref6547
type: UnificationXref
id: 3644593
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644593

Evidence1319
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10745006
xref: http://identifiers.org/pubmed/15946682
xref: http://identifiers.org/pubmed/11839747
xref: http://identifiers.org/pubmed/2188967
xref: http://identifiers.org/pubmed/7918575
xref: PublicationXref2356
comment: The mitochondrial nranched-chain alpha-ketoacid dehydrogenase (BKCD) complex catalyzes the reactions of alpha-ketoisocaproate, alpha-keto beta-methylvalerate, or aalpha-ketoisovalerate with CoA and NAD+ to form isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA, respectively, and CO2 and NADH (Chuang and Shih 2001). While bovine and microbial BCKD complexes have been characterized most extensively (Reed and Hackert 1990), structural studies of individual components and subcomplexes of human BKCD have confirmed their structures and roles in the overall oxidative carboxylation process, and have related these features to the disruptive effects of mutations on branched-chain amino acid metabolism in vivo: E1a and E1b components - AEvarsson et al. 2000; E2 - Chang et al. 2002; E3- Brautigam et al. 2005. In addition, structural studies have confirmed the lipoylation of lysine residue 44 in E2 protein (Chang et al. 2002) and the loss of an aminoterminal mitochondrial transport sequence from mature E3 protein (Bruatigam et al. 2005). Loss of mitochondrial transport sequences from proteins E1a, E1b, and E2 has been domstrated by sequence analysis (Wynn et al. 1999).

UnificationXref6546
type: UnificationXref
id: Q54TU9
db: UniProt

UnificationXref6549
type: UnificationXref
id: REACT_156684
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156684.3

http://identifiers.org/pubmed/20110263
type: PublicationXref
id: 20110263
author: Kersten, S
author: de Groot, PJ
author: de Vries, SC
author: Muller, M
author: Degenhardt, T
author: Carlberg, C
author: Vaisanen, S
author: Heinaniemi, M
author: van der Meer, DL
db: Pubmed
title: Profiling of promoter occupancy by PPAR{alpha} in human hepatoma cells via ChIP-chip analysis
source: Nucleic Acids Res
year: 2010

UnificationXref6548
type: UnificationXref
id: 3644595
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644595

UnificationXref6590
type: UnificationXref
id: 3644480
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644480

Ensembl:DDB0232045
type: ProteinReference
xref: UnificationXref7596
organism: Dictyostelium discoideum

Signaling by SCF-KIT
type: Pathway
data source: Provenance1
pathway component: REACT 149199.4
evidence: Evidence1592
xref: UnificationXref11000
xref: UnificationXref10999
pathway order: PathwayStep71
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

BRF1:mRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2079
component stoichiometry: Stoichiometry2080
component: Protein2253
component: PhysicalEntity247
xref: UnificationXref10546
cellular location: GO:0005829
comment: Reactome DB_ID: 3647810

Phosphorylated BRF1 (Ser92, Ser203):mRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2084
component stoichiometry: Stoichiometry2083
component: PhysicalEntity247
component: Protein2254
xref: UnificationXref10550
cellular location: GO:0005829
comment: Reactome DB_ID: 3647818

TTP:mRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2085
component stoichiometry: Stoichiometry2087
component stoichiometry: Stoichiometry2086
component: Protein2256
component: PhysicalEntity248
component: Protein2255
xref: UnificationXref10560
cellular location: GO:0005829
comment: Reactome DB_ID: 3647788

UnificationXref6598
type: UnificationXref
id: REACT_10931
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10931.1

HuR with phosphoserine221 and phosphoserine158:mRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2093
component stoichiometry: Stoichiometry2092
component: PhysicalEntity249
component: Protein2260
xref: UnificationXref10584
cellular location: GO:0005654
comment: Reactome DB_ID: 3647869

UnificationXref6597
type: UnificationXref
id: 192136
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192136

HuR with phosphoserine221 and phosphoserine318:mRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2095
component stoichiometry: Stoichiometry2094
component: Protein2264
component: PhysicalEntity250
xref: UnificationXref10589
cellular location: GO:0005654
comment: Reactome DB_ID: 3647870

UnificationXref6596
type: UnificationXref
id: CHEBI:17899
db: ChEBI

HuR with Unknown Phosphorylation: mRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2096
component stoichiometry: Stoichiometry2097
component: Protein2257
component: PhysicalEntity251
xref: UnificationXref10594
cellular location: GO:0005654
comment: Reactome DB_ID: 3647830

UnificationXref6595
type: UnificationXref
id: REACT_96410
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96410.9

(GlcN)1 (Ino(acyl)-P)1 (Man)4 (EtN)3 (P)3
type: SmallMoleculeReference
xref: UnificationXref12534

SMG1:UPF1:EJC:Translated mRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2098
component stoichiometry: Stoichiometry2209
component stoichiometry: Stoichiometry2213
component: Protein2268
component: Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction (name copied from entity in Homo sapiens)
component: SMG1:SMG8:SMG9 Complex (name copied from entity in Homo sapiens)
xref: UnificationXref10807
cellular location: GO:0005829
comment: Reactome DB_ID: 3648691

UnificationXref6594
type: UnificationXref
id: 3644499
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644499

Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2107
component stoichiometry: Stoichiometry2195
component stoichiometry: Stoichiometry2106
component stoichiometry: Stoichiometry2208
component stoichiometry: Stoichiometry2198
component stoichiometry: Stoichiometry2099
component: mRNA Complex with a Premature Termination Codon Preceding an Exon Junction (name copied from entity in Homo sapiens)
component: GDP bound eRF3 (name copied from entity in Homo sapiens)
component: 80S ribosome (name copied from entity in Homo sapiens)
component: Exon Junction:UPF2:UPF3 Complex (name copied from entity in Homo sapiens)
component: SmallMolecule1138
component: Protein2272
xref: UnificationXref10801
cellular location: GO:0005829
comment: Reactome DB_ID: 3648675

UnificationXref6593
type: UnificationXref
id: 3644489
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644489

mRNA Complex with a Premature Termination Codon Preceding an Exon Junction (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2104
component stoichiometry: Stoichiometry2101
component stoichiometry: Stoichiometry2105
component stoichiometry: Stoichiometry2100
component: PhysicalEntity253
component: PhysicalEntity252
component: Protein2269
component: Cap Binding Complex (CBC) (name copied from entity in Homo sapiens)
xref: UnificationXref10614
cellular location: GO:0005829
comment: Reactome DB_ID: 3648662

Ensembl:DDB0302550
type: ProteinReference
xref: UnificationXref7422
organism: Dictyostelium discoideum

UnificationXref6592
type: UnificationXref
id: 3644488
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644488

(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI
type: SmallMoleculeReference
name: acyl-GPI group
xref: UnificationXref12524

Cap Binding Complex (CBC) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2103
component stoichiometry: Stoichiometry2102
component: Protein2270
component: Protein2271
xref: UnificationXref10611
cellular location: GO:0005829
comment: Reactome DB_ID: 3642348

UnificationXref6591
type: UnificationXref
id: 3644484
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644484

Ubiquitinated AUF1 Tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2077
component: Protein2250
xref: UnificationXref10536
cellular location: GO:0005829
comment: Reactome DB_ID: 3647806

UnificationXref6599
type: UnificationXref
id: CHEBI:2290
db: ChEBI

Ensembl:DDB0231606
type: ProteinReference
xref: UnificationXref7418
organism: Dictyostelium discoideum

Ensembl:DDB0217804
type: ProteinReference
xref: UnificationXref7420
organism: Dictyostelium discoideum

THF-polyglutamate
type: SmallMoleculeReference
name: Tetrahydrofolyl-[Glu](n)
name: Tetrahydrofolyl-[Glu](n) [ChEBI:9484]
name: Tetrahydrofolyl-[Glu](n+1)
xref: UnificationXref8957

Decapped mRNA:LSM1-7 Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2067
component stoichiometry: Stoichiometry2068
component: PhysicalEntity245
component: Lsm1-7 Complex (name copied from entity in Homo sapiens)
xref: UnificationXref10511
cellular location: GO:0005829
comment: Reactome DB_ID: 3647264

Phosphorylated AUF1 p40 Dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2070
component: Protein2249
xref: UnificationXref10523
cellular location: GO:0005829
comment: Reactome DB_ID: 3647795

AUF1 Tetramer: Destabilized mRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2075
component stoichiometry: Stoichiometry2074
component: PhysicalEntity246
component: AUF1 Tetramer (isoform p37 or p40)
xref: UnificationXref10530
cellular location: GO:0005829
comment: Reactome DB_ID: 3647800

UniProt:Q55DV9
type: ProteinReference
xref: UnificationXref9778
organism: Dictyostelium discoideum

AUF1 Dimer (isoform p37 or p40)
type: Complex
data source: Provenance1
member physical entity: Phosphorylated AUF1 p40 Dimer (name copied from entity in Homo sapiens)
member physical entity: AUF1 p37 Dimer (name copied from entity in Homo sapiens)
xref: UnificationXref10524
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3647796

AUF1 p37 Dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2069
component: Protein2248
xref: UnificationXref10521
cellular location: GO:0005829
comment: Reactome DB_ID: 3647791

Phosphorylated AUF1 p40 Tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2073
component: Protein2249
xref: UnificationXref10528
cellular location: GO:0005829
comment: Reactome DB_ID: 3647798

Ubiquitinated AUF1 Tetramer: Destabilized mRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2078
component stoichiometry: Stoichiometry2076
component: PhysicalEntity246
component: Ubiquitinated AUF1 Tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref10537
cellular location: GO:0005829
comment: Reactome DB_ID: 3647807

AUF1 Tetramer (isoform p37 or p40)
type: Complex
data source: Provenance1
member physical entity: AUF1 p37 Tetramer (name copied from entity in Homo sapiens)
member physical entity: Phosphorylated AUF1 p40 Tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref10529
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3647799

AUF1 p37 Tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2072
component: Protein2248
xref: UnificationXref10527
cellular location: GO:0005829
comment: Reactome DB_ID: 3647797

(S)-3-Hydroxyoctanoyl-CoA
type: SmallMoleculeReference
name: (S)-Hydroxyoctanoyl-CoA [ChEBI:28632]
name: (S)-Hydroxyoctanoyl-CoA
xref: UnificationXref6054

UniProt:Q9GS21
type: ProteinReference
xref: UnificationXref10626
organism: Dictyostelium discoideum

UniProt:Q55E61
type: ProteinReference
xref: UnificationXref3543
organism: Dictyostelium discoideum

UnificationXref6572
type: UnificationXref
id: REACT_104081
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104081.9

UnificationXref6571
type: UnificationXref
id: 3644861
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644861

UnificationXref6570
type: UnificationXref
id: 3644859
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644859

UniProt:Q55E68
type: ProteinReference
xref: UnificationXref2086
organism: Dictyostelium discoideum

UnificationXref6576
type: UnificationXref
id: CHEBI:17737
db: ChEBI

UnificationXref6575
type: UnificationXref
id: REACT_10906
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10906.1

UnificationXref6574
type: UnificationXref
id: 195655
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=195655

UnificationXref6573
type: UnificationXref
id: CHEBI:27910
db: ChEBI

UnificationXref6579
type: UnificationXref
id: 3644868
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644868

UnificationXref6577
type: UnificationXref
id: 196420
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=196420

UnificationXref6578
type: UnificationXref
id: REACT_10980
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10980.2

Procainamide [ChEBI:8428]
type: SmallMoleculeReference
name: Procainamide
xref: UnificationXref3004

http://identifiers.org/pubmed/8163052
type: PublicationXref
id: 8163052
author: Gomis, R
author: Malaisse, WJ
author: Sener, A
author: Fernandez-Alvarez, J
author: Conget, I
author: Rasschaert, J
db: Pubmed
title: Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients
source: Diabetologia 37:177-81
year: 1994

http://identifiers.org/pubmed/15080793
type: PublicationXref
id: 15080793
author: Wenk, MR
author: Uhlén, P
author: Lee, E
author: De Camilli, P
author: Ehrlich, BE
author: Degray, B
author: Johenning, FW
db: Pubmed
title: InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1
source: Biochem J 382:687-94
year: 2004

1-Phosphatidyl-D-myo-inositol
type: SmallMoleculeReference
name: 1-phosphatidyl-1D-myo-inositol [ChEBI:16749]
name: PtdIns
name: 1-Phosphatidyl-myo-inositol
name: 1-phosphatidyl-1D-myo-inositol
name: 1,2-diacyl-sn-glycero(3)phospho(1)-D-myo-inositol
name: phosphoinositide
name: 1-(3-sn-phosphatidyl)-D-myo-inositol
name: Phosphatidyl-1D-myo-inositol
name: (3-Phosphatidyl)-1-D-inositol
xref: UnificationXref12455

http://identifiers.org/pubmed/9461497
type: PublicationXref
id: 9461497
author: Zhang, H
author: Tai, HH
author: Ensor, CM
db: Pubmed
title: Purification, cDNA cloning and expression of 15-oxoprostaglandin 13-reductase from pig lung
source: Biochem J 330:103-8
year: 1998

UnificationXref93
type: UnificationXref
id: 3645180
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645180

UnificationXref6581
type: UnificationXref
id: REACT_153873
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153873.3

UnificationXref92
type: UnificationXref
id: DDB0233655
db: Ensembl

UnificationXref6580
type: UnificationXref
id: 3644870
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644870

UnificationXref91
type: UnificationXref
id: REACT_81052
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81052.9

UnificationXref6583
type: UnificationXref
id: REACT_106916
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106916.9

dolichyl D-mannosyl phosphate [ChEBI:15809]
type: SmallMoleculeReference
name: Dolichyl phosphate D-mannose
name: dolichyl D-mannosyl phosphate
xref: UnificationXref12441

UnificationXref90
type: UnificationXref
id: 3645139
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645139

UnificationXref6582
type: UnificationXref
id: 3652033
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652033

UnificationXref97
type: UnificationXref
id: 3645192
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645192

UnificationXref6585
type: UnificationXref
id: 192195
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192195

UnificationXref96
type: UnificationXref
id: REACT_105713
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105713.9

UnificationXref6584
type: UnificationXref
id: CHEBI:28477
db: ChEBI

UnificationXref95
type: UnificationXref
id: 3645191
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645191

UnificationXref6587
type: UnificationXref
id: CHEBI:2288
db: ChEBI

UnificationXref94
type: UnificationXref
id: 3645181
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645181

UnificationXref6586
type: UnificationXref
id: REACT_10471
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10471.1

UnificationXref6588
type: UnificationXref
id: 192064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192064

UnificationXref6589
type: UnificationXref
id: REACT_10393
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10393.1

UnificationXref98
type: UnificationXref
id: 3645193
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645193

UnificationXref99
type: UnificationXref
id: REACT_82160
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82160.9

3-Methyl-2-oxopentanoate
type: SmallMoleculeReference
name: 2-Oxo-3-methylvalerate
name: 3-Methyl-2-oxopentanoate [ChEBI:28654]
xref: UnificationXref9173

RelationshipXref177
type: RelationshipXref
id: 3647106
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647106

UnificationXref2008
type: UnificationXref
id: Q54C29
db: UniProt

RelationshipXref176
type: RelationshipXref
id: GO:0015333
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2007
type: UnificationXref
id: 3641963
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641963

RelationshipXref175
type: RelationshipXref
id: 3645951
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645951

UnificationXref2006
type: UnificationXref
id: Q86KZ2
db: UniProt

SequenceSite2788
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref174
type: RelationshipXref
id: GO:0005310
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2005
type: UnificationXref
id: 3641951
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641951

SequenceSite2789
type: SequenceSite
position status: EQUAL
sequence position: 697

RelationshipXref173
type: RelationshipXref
id: GO:0006865
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2004
type: UnificationXref
id: Q55G81
db: UniProt

SequenceSite2786
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref172
type: RelationshipXref
id: 3646006
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3646006

UnificationXref2003
type: UnificationXref
id: 3641947
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641947

SequenceSite2787
type: SequenceSite
position status: EQUAL
sequence position: 683

RelationshipXref171
type: RelationshipXref
id: 3646003
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3646003

UnificationXref2002
type: UnificationXref
id: 3641942
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641942

SequenceSite2784
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref170
type: RelationshipXref
id: 3646009
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3646009

UnificationXref2001
type: UnificationXref
id: 3641946
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641946

SequenceSite2785
type: SequenceSite
position status: EQUAL
sequence position: 683

SequenceSite2782
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2783
type: SequenceSite
position status: EQUAL
sequence position: 698

SequenceSite2780
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2781
type: SequenceSite
position status: EQUAL
sequence position: 698

UnificationXref4389
type: UnificationXref
id: 30185
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30185

UnificationXref4388
type: UnificationXref
id: CHEBI:16311
db: ChEBI

UnificationXref2009
type: UnificationXref
id: 3641967
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641967

UnificationXref4384
type: UnificationXref
id: 30595
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30595

UnificationXref4385
type: UnificationXref
id: REACT_4491
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4491.1

UniProt:Q55D99
type: ProteinReference
xref: UnificationXref503
organism: Dictyostelium discoideum

UnificationXref4386
type: UnificationXref
id: 3639822
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639822

UnificationXref4387
type: UnificationXref
id: REACT_103048
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103048.9

UnificationXref4380
type: UnificationXref
id: REACT_2826
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2826.1

UnificationXref4381
type: UnificationXref
id: CHEBI:15713
db: ChEBI

UnificationXref4382
type: UnificationXref
id: 113562
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113562

UnificationXref4383
type: UnificationXref
id: REACT_3782
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3782.1

UniProt:Q8T2T5
type: ProteinReference
xref: UnificationXref8052
organism: Dictyostelium discoideum

UnificationXref2000
type: UnificationXref
id: DDB0304902
db: Ensembl

RelationshipXref178
type: RelationshipXref
id: GO:0006811
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/6434529
type: PublicationXref
id: 6434529
author: Chuang, DT
author: Cox, RP
author: Markovitz, PJ
db: Pubmed
title: Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.
source: J Biol Chem 259:11643-6
year: 1984

RelationshipXref179
type: RelationshipXref
id: GO:0005353
db: GENE ONTOLOGY
relationship type: MI:0355

Propanoyl-CoA:carbon dioxide ligase alpha subunit
type: Protein
entity reference: Ensembl:DDB0230063
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PCCA_HUMAN
name: propionyl-CoA carboxylase alpha chain, apoprotein
name: PCCase alpha subunit
name: DDB0230063
name: Propionyl-CoA carboxylase alpha chain, mitochondrial precursor
xref: UnificationXref8830
feature: FragmentFeature1706
cellular location: GO:0005829
comment: Reactome DB_ID: 3651536
display name: PCCA

RelationshipXref186
type: RelationshipXref
id: GO:0015758
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite2777
type: SequenceSite
position status: EQUAL
sequence position: 786

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0204262
data source: Provenance1
name: DDB0204262
name: MMAB_HUMAN
name: MMAB
xref: UnificationXref8814
feature: FragmentFeature1705
cellular location: GO:0005759
comment: Reactome DB_ID: 3651647
display name: Cob

RelationshipXref185
type: RelationshipXref
id: 3647774
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647774

SequenceSite2778
type: SequenceSite
position status: EQUAL
sequence position: 1

Propanoyl-CoA:carbon dioxide ligase alpha subunit
type: Protein
entity reference: Ensembl:DDB0230063
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: PCCA_HUMAN
name: propionyl-CoA carboxylase alpha chain, apoprotein
name: PCCase alpha subunit
name: DDB0230063
name: Propionyl-CoA carboxylase alpha chain, mitochondrial precursor
xref: UnificationXref8837
feature: FragmentFeature1708
feature: ModificationFeature192
cellular location: GO:0005829
comment: Reactome DB_ID: 3651539
display name: Btn-PCCA

RelationshipXref188
type: RelationshipXref
id: GO:0055056
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite2779
type: SequenceSite
position status: EQUAL
sequence position: 2346

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0235357
data source: Provenance1
name: Propanoyl-CoA:carbon dioxide ligase beta subunit
name: PCCB_HUMAN
name: DDB0235357
name: Propionyl-CoA carboxylase beta chain, mitochondrial precursor
name: propionyl-CoA carboxylase beta chain
name: PCCase beta subunit
xref: UnificationXref8831
feature: FragmentFeature1707
cellular location: GO:0005829
comment: Reactome DB_ID: 3651535
display name: PCCB

RelationshipXref187
type: RelationshipXref
id: GO:0008645
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref182
type: RelationshipXref
id: 3644314
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644314

SequenceSite2773
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref181
type: RelationshipXref
id: GO:0015149
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite2774
type: SequenceSite
position status: EQUAL
sequence position: 303

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0189571
data source: Provenance1
name: MTRR_HUMAN
name: Methionine synthase reductase
name: DDB0189571
xref: UnificationXref8780
feature: FragmentFeature1704
cellular location: GO:0005829
comment: Reactome DB_ID: 3644087
display name: MTRR

RelationshipXref184
type: RelationshipXref
id: 3640260
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640260

SequenceSite2775
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref183
type: RelationshipXref
id: GO:0005355
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite2776
type: SequenceSite
position status: EQUAL
sequence position: 1101

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54KE6
data source: Provenance1
name: Q54KE6
name: methylcrotonyl-CoA carboxylase alpha chain
xref: UnificationXref8850
feature: FragmentFeature1712
cellular location: GO:0005829
comment: Reactome DB_ID: 3651578
display name: MCCC1

SequenceSite2770
type: SequenceSite
position status: EQUAL
sequence position: 1332

RelationshipXref180
type: RelationshipXref
id: 3644312
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644312

SequenceSite2771
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite2772
type: SequenceSite
position status: EQUAL
sequence position: 1332

http://identifiers.org/pubmed/8946167
type: PublicationXref
id: 8946167
author: Blanch, L
author: Anson, D S
author: Hopwood, J J
author: Scott, H S
author: Guo, X H
author: Karageorgos, L E
author: Weber, B
db: Pubmed
title: Structure and sequence of the human sulphamidase gene
source: DNA Res. 3:269-71
year: 1996

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0304892
data source: Provenance1
name: DDB0304892
name: BPL1_HUMAN
name: Biotin--protein ligase ecNumber6.3.4.-/ecNumber
xref: UnificationXref8841
feature: FragmentFeature1709
cellular location: GO:0005829
comment: Reactome DB_ID: 3651545
display name: HLCS

Homologues of HLCS
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8846
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3651554

UnificationXref4379
type: UnificationXref
id: 29470
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29470

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0304891
data source: Provenance1
name: DDB0304891
name: BPL1_HUMAN
name: Biotin--protein ligase ecNumber6.3.4.-/ecNumber
xref: UnificationXref8845
feature: FragmentFeature1711
cellular location: GO:0005829
comment: Reactome DB_ID: 3651553
display name: HLCS

UnificationXref4378
type: UnificationXref
id: CHEBI:17677
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0304893
data source: Provenance1
name: DDB0304893
name: BPL1_HUMAN
name: Biotin--protein ligase ecNumber6.3.4.-/ecNumber
xref: UnificationXref8843
feature: FragmentFeature1710
cellular location: GO:0005829
comment: Reactome DB_ID: 3651549
display name: HLCS

UnificationXref4377
type: UnificationXref
id: REACT_92979
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92979.9

UnificationXref4375
type: UnificationXref
id: REACT_154932
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154932.3

UnificationXref4376
type: UnificationXref
id: 3652010
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652010

UnificationXref4373
type: UnificationXref
id: 3644279
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644279

UnificationXref4374
type: UnificationXref
id: 3644280
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644280

UnificationXref4371
type: UnificationXref
id: 3639864
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639864

UnificationXref4372
type: UnificationXref
id: 3643946
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643946

UnificationXref4370
type: UnificationXref
id: 3639859
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639859

UniProt:Q55CY3
type: ProteinReference
xref: UnificationXref9330
organism: Dictyostelium discoideum

trans-Hex-2-enoyl-CoA [ChEBI:28706]
type: SmallMoleculeReference
name: trans-Hex-2-enoyl-CoA
xref: UnificationXref6061

RelationshipXref189
type: RelationshipXref
id: 3647199
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647199

http://identifiers.org/pubmed/8228618
type: PublicationXref
id: 8228618
author: Brown, EJ
author: Lefkowith, JB
author: Bromley, FA
author: Lennartz, MR
db: Pubmed
title: Immunoglobulin G-mediated phagocytosis activates a calcium-independent, phosphatidylethanolamine-specific phospholipase
source: J Leukoc Biol 54:389-98
year: 1993

UniProt:Q8T2Q6
type: ProteinReference
xref: UnificationXref6791
organism: Dictyostelium discoideum

RelationshipXref195
type: RelationshipXref
id: 3647359
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647359

RelationshipXref194
type: RelationshipXref
id: GO:0015307
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref193
type: RelationshipXref
id: 3647216
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647216

RelationshipXref192
type: RelationshipXref
id: 3647208
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647208

Homologues of SLC25A16
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref8722
cellular location: GO:0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3645079

RelationshipXref199
type: RelationshipXref
id: 3647368
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647368

Bifunctional coenzyme A synthase
type: Protein
entity reference: Ensembl:DDB0231517
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: COAS_HUMAN
name: DDB0231517
xref: UnificationXref8713
feature: FragmentFeature1697
cellular location: GO:0005741
comment: Reactome DB_ID: 3644881
display name: COASY

RelationshipXref198
type: RelationshipXref
id: GO:0005381
db: GENE ONTOLOGY
relationship type: MI:0355

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54Y51
data source: Provenance1
name: Phosphopantothenoylcysteine decarboxylase
name: Q54Y51
name: COAC_HUMAN
xref: UnificationXref8705
feature: FragmentFeature1696
cellular location: GO:0005829
comment: Reactome DB_ID: 3644896
display name: PPCDC

RelationshipXref197
type: RelationshipXref
id: 3647365
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647365

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0231514
data source: Provenance1
name: DDB0231514
name: COAB
name: PPCS_HUMAN
name: Phosphopantothenate-cysteine ligase
xref: UnificationXref8697
feature: FragmentFeature1695
cellular location: GO:0005829
comment: Reactome DB_ID: 3644874
display name: PPCS

RelationshipXref196
type: RelationshipXref
id: GO:0051139
db: GENE ONTOLOGY
relationship type: MI:0355

PNPO(1-216)
type: Protein
entity reference: Q54YS6
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q54YS6
name: Pyridoxine-5'-phosphate oxidase
xref: UnificationXref8756
feature: FragmentFeature1701
cellular location: GO:0005829
comment: Reactome DB_ID: 3648838
display name: PNPO

UnificationXref4367
type: UnificationXref
id: Q54KM3
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q55EK9
data source: Provenance1
name: Q55EK9
name: Pyridoxal kinase
xref: UnificationXref8733
feature: FragmentFeature1700
cellular location: GO:0005829
comment: Reactome DB_ID: 3648829
display name: PDXK

UnificationXref4366
type: UnificationXref
id: REACT_159206
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159206.3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54DU1
data source: Provenance1
name: Grave disease autoantigen
name: SLC25A16
xref: UnificationXref8721
feature: FragmentFeature1699
cellular location: GO:0005743
comment: Reactome DB_ID: 3645078
display name: Q54DU1

UnificationXref4369
type: UnificationXref
id: 3639858
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639858

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54QI8
data source: Provenance1
name: Grave disease autoantigen
name: SLC25A16
xref: UnificationXref8719
feature: FragmentFeature1698
cellular location: GO:0005743
comment: Reactome DB_ID: 3645074
display name: Q54QI8

UnificationXref4368
type: UnificationXref
id: 3639863
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639863

http://identifiers.org/pubmed/15720390
type: PublicationXref
id: 15720390
author: Fabre, AL
author: Orlean, P
author: Taron, CH
db: Pubmed
title: Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly
source: FEBS J 272:1160-8
year: 2005

RelationshipXref191
type: RelationshipXref
id: 3647196
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647196

RelationshipXref190
type: RelationshipXref
id: GO:0051119
db: GENE ONTOLOGY
relationship type: MI:0355

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54P92
data source: Provenance1
name: Methionine synthase
name: Q54P92
xref: UnificationXref8777
feature: FragmentFeature1703
cellular location: GO:0005829
comment: Reactome DB_ID: 3644092
display name: MTR

http://identifiers.org/pubmed/11826276
type: PublicationXref
id: 11826276
author: Bennett, MJ
author: Rinaldo, P
author: Matern, D
db: Pubmed
title: Fatty acid oxidation disorders.
source: Annu Rev Physiol 64:477-502
year: 2002

Q54KD1
type: Protein
entity reference: Q54KD1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Probable lysosomal cobalamin transporter
name: LMBD1_HUMAN
xref: UnificationXref8770
feature: FragmentFeature1702
cellular location: GO:0005765
comment: Reactome DB_ID: 3651608
display name: LMBRD1

UnificationXref8399
type: UnificationXref
id: 3641859
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641859

UnificationXref4360
type: UnificationXref
id: 3644030
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644030

http://identifiers.org/pubmed/9207062
type: PublicationXref
id: 9207062
author: Demple, B
author: Wilson, DM
author: Bennett, RA
author: Wong, D
db: Pubmed
title: Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.
source: Proc Natl Acad Sci U S A 94:7166-9
year: 1997

UnificationXref4361
type: UnificationXref
id: 3644031
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644031

UnificationXref8397
type: UnificationXref
id: REACT_3334
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3334.2

UnificationXref4362
type: UnificationXref
id: 3644065
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644065

http://identifiers.org/pubmed/10366852
type: PublicationXref
id: 10366852
author: Soderling, TR
db: Pubmed
title: The Ca-calmodulin-dependent protein kinase cascade
source: Trends Biochem Sci 24:232-6
year: 1999

UnificationXref8398
type: UnificationXref
id: Q27564
db: UniProt

UnificationXref4363
type: UnificationXref
id: REACT_159788
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159788.3

UnificationXref8395
type: UnificationXref
id: CHEBI:17013
db: ChEBI

UnificationXref4364
type: UnificationXref
id: 3644033
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644033

UnificationXref8396
type: UnificationXref
id: 109366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109366

UnificationXref4365
type: UnificationXref
id: 3644035
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644035

UnificationXref8393
type: UnificationXref
id: 3642787
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642787

UnificationXref8394
type: UnificationXref
id: 3642789
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642789

UnificationXref8391
type: UnificationXref
id: REACT_101038
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101038.9

UnificationXref8392
type: UnificationXref
id: 3642786
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642786

UnificationXref8390
type: UnificationXref
id: 3641845
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641845

SequenceSite2795
type: SequenceSite
position status: EQUAL
sequence position: 559

SequenceSite2796
type: SequenceSite
position status: EQUAL
sequence position: 38

SequenceSite2797
type: SequenceSite
position status: EQUAL
sequence position: 456

SequenceSite2798
type: SequenceSite
position status: EQUAL
sequence position: 1

SASP
type: Protein
entity reference: Q54KN7
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: Q54KN7
name: ATL-derived factor
name: ADF
name: Surface associated sulphydryl protein
xref: UnificationXref8552
feature: FragmentFeature1685
cellular location: GO:0005654
comment: Reactome DB_ID: 3642948
display name: TXN

SequenceSite2799
type: SequenceSite
position status: EQUAL
sequence position: 283

non-metastatic cells 1, protein (NM23A) expressed in
type: Protein
entity reference: P22887
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Tumor metastatic process-associated protein
name: Nucleoside diphosphate kinase A
name: nm23-H1
name: P22887
name: Metastasis inhibition factor nm23
name: NDP kinase A
name: NME1(2-152)
xref: UnificationXref8573
feature: FragmentFeature1687
cellular location: GO:0005829
comment: Reactome DB_ID: 3647964
display name: NDK A

SASP
type: Protein
entity reference: P29447
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: ATL-derived factor
name: ADF
name: P29447
name: Surface associated sulphydryl protein
xref: UnificationXref8553
feature: FragmentFeature1686
cellular location: GO:0005654
comment: Reactome DB_ID: 3642949
display name: TXN

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54LQ6
data source: Provenance1
name: Q54LQ6
name: Inosine triphosphate pyrophosphatase
xref: UnificationXref8623
feature: FragmentFeature1689
cellular location: GO:0005829
comment: Reactome DB_ID: 3651223
display name: ITPA

UnificationXref4358
type: UnificationXref
id: 3644076
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644076

Nucleoside diphosphate kinase, mitochondrial
type: Protein
entity reference: P22887
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P22887
name: nm23-H4
name: non-metastatic cells 4, protein expressed in
name: NDP kinase, mitochondrial
xref: UnificationXref8611
feature: FragmentFeature1688
cellular location: GO:0005743
comment: Reactome DB_ID: 3648016
display name: NME4

UnificationXref4357
type: UnificationXref
id: 3644032
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644032

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q559K0
data source: Provenance1
name: Solute carrier family19 member 2
name: Thiamine transporter 1
name: SLC19A2
name: Q559K0
xref: UnificationXref8668
feature: FragmentFeature1691
cellular location: GO:0005886
comment: Reactome DB_ID: 3645094
display name: THTR1

UnificationXref4356
type: UnificationXref
id: 3639856
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639856

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0204862
data source: Provenance1
name: Nudix motif 5
name: ADP-sugar pyrophosphatase
name: DDB0204862
xref: UnificationXref8644
feature: FragmentFeature1690
cellular location: GO:0005829
comment: Reactome DB_ID: 3651025
display name: NUDT5

UnificationXref4355
type: UnificationXref
id: 3639855
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639855

SequenceSite2790
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0185283
data source: Provenance1
name: Q8NFF5_HUMAN
name: FAD1 flavin adenine dinucleotide synthetase homolog
name: DDB0185283
xref: UnificationXref8681
feature: FragmentFeature1693
cellular location: GO:0005829
comment: Reactome DB_ID: 3644903
display name: FLAD1

SequenceSite2791
type: SequenceSite
position status: EQUAL
sequence position: 697

Steroid hormones
type: Pathway
data source: Provenance1
pathway component: REACT 96247.9
pathway component: REACT 134590.5
pathway component: REACT 98944.9
pathway component: REACT 89387.9
evidence: Evidence275
xref: UnificationXref2555
xref: UnificationXref2556
pathway order: PathwayStep256
pathway order: PathwayStep263
pathway order: PathwayStep265
pathway order: PathwayStep259
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0189361
data source: Provenance1
name: TPK1_HUMAN
name: Thiamin pyrophosphokinase 1
name: DDB0189361
xref: UnificationXref8674
feature: FragmentFeature1692
cellular location: GO:0005829
comment: Reactome DB_ID: 3644887
display name: TPK1

SequenceSite2792
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2793
type: SequenceSite
position status: EQUAL
sequence position: 308

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0232174
data source: Provenance1
name: DDB0232174
name: Ectonucleotide pyrophosphatase/phosphodiesterase 1
name: NPP1_HUMAN
xref: UnificationXref8684
feature: FragmentFeature1694
cellular location: GO:0005886
comment: Reactome DB_ID: 3644909
display name: ENPP1

UnificationXref4359
type: UnificationXref
id: REACT_90998
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90998.9

SequenceSite2794
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref4350
type: UnificationXref
id: 3643882
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643882

UnificationXref4353
type: UnificationXref
id: 3643944
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643944

UnificationXref4354
type: UnificationXref
id: REACT_156633
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156633.3

UnificationXref4351
type: UnificationXref
id: 3643883
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643883

UnificationXref4352
type: UnificationXref
id: 3643943
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643943

UniProt:Q55D85
type: ProteinReference
xref: UnificationXref6496
organism: Dictyostelium discoideum

UniProt:Q55CW5
type: ProteinReference
xref: UnificationXref10713
organism: Dictyostelium discoideum

RelationshipXref132
type: RelationshipXref
id: GO:0016556
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref133
type: RelationshipXref
id: GO:0000398
db: GENE ONTOLOGY
relationship type: MI:0359

ATP6V0A (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2339
component stoichiometry: Stoichiometry2338
component stoichiometry: Stoichiometry2341
component stoichiometry: Stoichiometry2340
component: Protein2620
component: Protein2621
component: Protein2619
component: Protein2618
xref: UnificationXref11487
cellular location: GO:0030670
comment: Reactome DB_ID: 3649237

RelationshipXref130
type: RelationshipXref
id: GO:0006370
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2049
type: UnificationXref
id: Q54KR9
db: UniProt

RelationshipXref131
type: RelationshipXref
id: GO:0016554
db: GENE ONTOLOGY
relationship type: MI:0359

Ensembl:DDB0188248
type: ProteinReference
xref: UnificationXref6340
organism: Dictyostelium discoideum

UnificationXref2047
type: UnificationXref
id: Q55D17
db: UniProt

UnificationXref2048
type: UnificationXref
id: 3640935
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640935

Inhibition of replication initiation of damaged DNA by RB1/E2F1
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction308
evidence: Evidence546
xref: UnificationXref4333
xref: UnificationXref4334
pathway order: PathwayStep531
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref2045
type: UnificationXref
id: 3642695
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642695

UnificationXref2046
type: UnificationXref
id: REACT_82482
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82482.9

FGFR1 fusion mutant dimers:TKIs (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2351
component stoichiometry: Stoichiometry2352
component: SmallMolecule1146
component: FGFR1 fusion mutant dimers
xref: UnificationXref11553
cellular location: GO:0005829
comment: Reactome DB_ID: 3650418

UnificationXref2044
type: UnificationXref
id: 3642694
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642694

Activated FGFR1 fusion mutants:PLC-gamma (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2353
component stoichiometry: Stoichiometry2354
component stoichiometry: Stoichiometry2355
component: SmallMolecule17
component: Protein1501
component: p-FGFR1 fusion mutant dimers
xref: UnificationXref11556
cellular location: GO:0005829
comment: Reactome DB_ID: 3650427

UnificationXref2043
type: UnificationXref
id: REACT_3793
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3793.1

Activated FGFR1 fusion mutants:p-PLCgamma (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2359
component stoichiometry: Stoichiometry2358
component: p-FGFR1 fusion mutant dimers
component: Protein145
xref: UnificationXref11559
cellular location: GO:0005829
comment: Reactome DB_ID: 3650429

RelationshipXref139
type: RelationshipXref
id: GO:0006700
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2042
type: UnificationXref
id: 111345
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111345

L-amino acid oxidase (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2361
component stoichiometry: Stoichiometry2360
component: SmallMolecule1154
component: Protein2635
xref: UnificationXref11590
cellular location: GO:0005576
comment: Reactome DB_ID: 3650797

RelationshipXref138
type: RelationshipXref
id: 3644866
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644866

UnificationXref2041
type: UnificationXref
id: REACT_78229
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78229.9

FGFR1 fusion mutant dimers
type: Complex
data source: Provenance1
member physical entity: CUX1-FGFR1 fusion mutant dimer (name copied from entity in Homo sapiens)
xref: UnificationXref11531
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3650416

RelationshipXref137
type: RelationshipXref
id: GO:0004032
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2040
type: UnificationXref
id: 3642693
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642693

CUX1-FGFR1 fusion mutant dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2346
component: Protein2633
xref: UnificationXref11530
cellular location: GO:0005829
comment: Reactome DB_ID: 3650415

RelationshipXref136
type: RelationshipXref
id: GO:0031124
db: GENE ONTOLOGY
relationship type: MI:0359

p-FGFR1 fusion mutant dimers
type: Complex
data source: Provenance1
member physical entity: CUX1-p-FGFR1 fusion mutant dimer (name copied from entity in Homo sapiens)
xref: UnificationXref11536
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3650424

RelationshipXref135
type: RelationshipXref
id: GO:0008334
db: GENE ONTOLOGY
relationship type: MI:0359

CUX1-p-FGFR1 fusion mutant dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2349
component: Protein2634
xref: UnificationXref11535
cellular location: GO:0005829
comment: Reactome DB_ID: 3650423

RelationshipXref134
type: RelationshipXref
id: GO:0008380
db: GENE ONTOLOGY
relationship type: MI:0359

AKT1 E17K mutant:PIP2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2363
component stoichiometry: Stoichiometry2362
component: Protein2652
component: SmallMolecule12
xref: UnificationXref11662
cellular location: GO:0005886
comment: Reactome DB_ID: 3650954

Ensembl:DDB0230167
type: ProteinReference
xref: UnificationXref6150
organism: Dictyostelium discoideum

PDPK1:p-S473-AKT1 E17K mutant:PIP2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2367
component stoichiometry: Stoichiometry2366
component: p-S473-AKT1 E17K mutant:PIP2 (name copied from entity in Homo sapiens)
component: PDPK1:PIP2 (name copied from entity in Homo sapiens)
xref: UnificationXref11669
cellular location: GO:0005886
comment: Reactome DB_ID: 3650966

RelationshipXref141
type: RelationshipXref
id: 3644535
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644535

UnificationXref2038
type: UnificationXref
id: REACT_5463
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5463.1

http://identifiers.org/pubmed/11742412
type: PublicationXref
id: 11742412
author: Saltiel, AR
author: Kahn, CR
db: Pubmed
title: Insulin signalling and the regulation of glucose and lipid metabolism
source: Nature 414:799-806
year: 2001

p-S473-AKT1 E17K mutant:PIP2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2365
component stoichiometry: Stoichiometry2364
component: Protein2653
component: SmallMolecule12
xref: UnificationXref11666
cellular location: GO:0005886
comment: Reactome DB_ID: 3650965

RelationshipXref142
type: RelationshipXref
id: GO:0003845
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2039
type: UnificationXref
id: 3642691
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642691

RelationshipXref143
type: RelationshipXref
id: 3644562
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644562

Ensembl:DDB0202803
type: ProteinReference
xref: UnificationXref6110
organism: Dictyostelium discoideum

RelationshipXref144
type: RelationshipXref
id: GO:0006704
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2034
type: UnificationXref
id: REACT_4307
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4307.1

UnificationXref2035
type: UnificationXref
id: 3642690
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642690

Ensembl:DDB0187533
type: ProteinReference
xref: UnificationXref6107
organism: Dictyostelium discoideum

UnificationXref2036
type: UnificationXref
id: REACT_93667
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93667.9

Ensembl:DDB0235357
type: ProteinReference
xref: UnificationXref6089
organism: Dictyostelium discoideum

RelationshipXref140
type: RelationshipXref
id: GO:0004508
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2037
type: UnificationXref
id: 111344
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111344

Ensembl:DDB0230063
type: ProteinReference
xref: UnificationXref6091
organism: Dictyostelium discoideum

Paused processive elongation complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2388
component stoichiometry: Stoichiometry2394
component stoichiometry: Stoichiometry2384
component stoichiometry: Stoichiometry2395
component stoichiometry: Stoichiometry2386
component stoichiometry: Stoichiometry2385
component stoichiometry: Stoichiometry2398
component stoichiometry: Stoichiometry2387
component stoichiometry: Stoichiometry2389
component stoichiometry: Stoichiometry2399
component: DSIF complex (name copied from entity in Homo sapiens)
component: Protein2671
component: FACT complex (name copied from entity in Homo sapiens)
component: Elongin Complex (name copied from entity in Homo sapiens)
component: P-TEFb complex (name copied from entity in Homo sapiens)
component: PhysicalEntity283
component: PhysicalEntity284
component: NELF complex (name copied from entity in Homo sapiens)
component: RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: Protein1129
xref: UnificationXref11757
cellular location: GO:0005654
comment: Reactome DB_ID: 3643243

UnificationXref2031
type: UnificationXref
id: 3642687
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642687

Elongin Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2383
component stoichiometry: Stoichiometry2380
component: Protein2667
component: Elongin B:C complex (name copied from entity in Homo sapiens)
xref: UnificationXref11743
cellular location: GO:0005654
comment: Reactome DB_ID: 3643238

RelationshipXref149
type: RelationshipXref
id: GO:0017081
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2030
type: UnificationXref
id: REACT_5617
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5617.1

http://identifiers.org/pubmed/18660845
type: PublicationXref
id: 18660845
author: Zhao, FQ
author: Keating, AF
db: Pubmed
title: Functional properties and genomics of glucose transporters
source: Curr Genomics 8:113-28
year: 2007

FACT complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2376
component stoichiometry: Stoichiometry2375
component: Protein2661
component: Protein2660
xref: UnificationXref11723
cellular location: GO:0005654
comment: Reactome DB_ID: 3643227

UnificationXref2033
type: UnificationXref
id: 111349
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111349

P-TEFb complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2378
component stoichiometry: Stoichiometry2377
component stoichiometry: Stoichiometry2379
component: Protein2663
component: Protein2662
component: Protein2664
xref: UnificationXref11734
cellular location: GO:0005654
comment: Reactome DB_ID: 3643189

UnificationXref2032
type: UnificationXref
id: 3642688
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642688

IDH1 R132H dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2372
component: Protein2656
xref: UnificationXref11706
cellular location: GO:0005829
comment: Reactome DB_ID: 3648372

RelationshipXref146
type: RelationshipXref
id: GO:0004303
db: GENE ONTOLOGY
relationship type: MI:0355

DSIF complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2374
component stoichiometry: Stoichiometry2373
component: Protein2659
component: Protein648
xref: UnificationXref11716
cellular location: GO:0005654
comment: Reactome DB_ID: 3643205

RelationshipXref145
type: RelationshipXref
id: GO:0006702
db: GENE ONTOLOGY
relationship type: MI:0359

AKT inhibitors:AKT (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2370
component stoichiometry: Stoichiometry2371
component: PhysicalEntity281
component: SmallMolecule1159
xref: UnificationXref11694
cellular location: GO:0005829
comment: Reactome DB_ID: 3651044

RelationshipXref148
type: RelationshipXref
id: GO:0006703
db: GENE ONTOLOGY
relationship type: MI:0359

IDH1 R132mutant dimers
type: Complex
data source: Provenance1
member physical entity: IDH1 R132H dimer (name copied from entity in Homo sapiens)
xref: UnificationXref11707
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3648373

RelationshipXref147
type: RelationshipXref
id: 3648318
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648318

RelationshipXref150
type: RelationshipXref
id: 3646487
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3646487

UnificationXref2025
type: UnificationXref
id: REACT_33657
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33657.10

Ensembl:DDB0234143
type: ProteinReference
xref: UnificationXref6486
organism: Dictyostelium discoideum

RelationshipXref151
type: RelationshipXref
id: GO:0005319
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2026
type: UnificationXref
id: 113571
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113571

UnificationXref2023
type: UnificationXref
id: REACT_3796
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3796.2

UnificationXref2024
type: UnificationXref
id: 3642686
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642686

RelationshipXref154
type: RelationshipXref
id: 3646448
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3646448

UnificationXref2029
type: UnificationXref
id: 29626
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29626

RelationshipXref155
type: RelationshipXref
id: GO:0015248
db: GENE ONTOLOGY
relationship type: MI:0355

Ensembl:DDB0302376
type: ProteinReference
xref: UnificationXref6536
organism: Dictyostelium discoideum

RelationshipXref152
type: RelationshipXref
id: 3649428
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649428

UnificationXref2027
type: UnificationXref
id: REACT_5587
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5587.1

RelationshipXref153
type: RelationshipXref
id: GO:0005324
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2028
type: UnificationXref
id: CHEBI:17345
db: ChEBI

RelationshipXref159
type: RelationshipXref
id: 3649436
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649436

RhoA/B/C:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2298
component stoichiometry: Stoichiometry2299
component: SmallMolecule11
component: PhysicalEntity269
xref: UnificationXref11240
cellular location: GO:0005886
comment: Reactome DB_ID: 3646913

RelationshipXref158
type: RelationshipXref
id: 3646435
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3646435

G protein alpha:GTP complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2301
component stoichiometry: Stoichiometry2300
component: PhysicalEntity270
component: SmallMolecule1
xref: UnificationXref11255
cellular location: GO:0005886
comment: Reactome DB_ID: 3642981

RelationshipXref157
type: RelationshipXref
id: GO:0015232
db: GENE ONTOLOGY
relationship type: MI:0355

G-protein alpha:GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2302
component stoichiometry: Stoichiometry2303
component: SmallMolecule2
component: PhysicalEntity270
xref: UnificationXref11256
cellular location: GO:0005886
comment: Reactome DB_ID: 3643103

RelationshipXref156
type: RelationshipXref
id: 3645775
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645775

Activated PLC beta 1/4 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2304
component stoichiometry: Stoichiometry2305
component: Protein2530
component: G protein alpha:GTP complex (name copied from entity in Homo sapiens)
xref: UnificationXref11262
cellular location: GO:0005886
comment: Reactome DB_ID: 3642982

UnificationXref2022
type: UnificationXref
id: 113550
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113550

PP2B catalytic (Fe3+, Zn2+) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2307
component stoichiometry: Stoichiometry2308
component stoichiometry: Stoichiometry2306
component: SmallMolecule108
component: Protein2531
component: SmallMolecule109
xref: UnificationXref11277
cellular location: GO:0005829
comment: Reactome DB_ID: 3645277

UnificationXref2021
type: UnificationXref
id: 3642684
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642684

PP2B catalytic (Fe3+, Zn2+):Active Calmodulin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2312
component stoichiometry: Stoichiometry2310
component stoichiometry: Stoichiometry2311
component stoichiometry: Stoichiometry2309
component: Active Calmodulin (name copied from entity in Homo sapiens)
component: SmallMolecule108
component: Protein2531
component: SmallMolecule109
xref: UnificationXref11278
cellular location: GO:0005829
comment: Reactome DB_ID: 3645278

UnificationXref2020
type: UnificationXref
id: REACT_5790
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5790.1

METAP1/2
type: Complex
data source: Provenance1
member physical entity: METAP2:2Co2+ (name copied from entity in Homo sapiens)
member physical entity: METAP1:2Co2+ (name copied from entity in Homo sapiens)
xref: UnificationXref11367
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3651315

METAP1:2Co2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2314
component stoichiometry: Stoichiometry2313
component: SmallMolecule1144
component: Protein2569
xref: UnificationXref11363
cellular location: GO:0005829
comment: Reactome DB_ID: 3651309

METAP2:2Co2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2315
component stoichiometry: Stoichiometry2316
component: SmallMolecule1144
component: Protein2570
xref: UnificationXref11366
cellular location: GO:0005829
comment: Reactome DB_ID: 3651314

Guanylate cyclase activating proteins:Ca2+
type: Complex
data source: Provenance1
member physical entity: GUCA1C:Ca2+ (name copied from entity in Homo sapiens)
member physical entity: GUCA1B:Ca2+ (name copied from entity in Homo sapiens)
member physical entity: GUCA1A:Ca2+ (name copied from entity in Homo sapiens)
xref: UnificationXref11409
cellular location: GO:0097381
display name: GUCA:Ca2+
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3651433

UnificationXref4399
type: UnificationXref
id: REACT_5621
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5621.1

http://identifiers.org/pubmed/15274622
type: PublicationXref
id: 15274622
author: Kim, JJ
author: Wang, M
author: Fu, Z
author: Paschke, R
author: Frerman, FE
author: Rao, KS
db: Pubmed
title: Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions
source: Biochemistry 43:9674-84
year: 2004

http://identifiers.org/pubmed/12669019
type: PublicationXref
id: 12669019
author: Desjardins, M
db: Pubmed
title: ER-mediated phagocytosis: a new membrane for new functions
source: Nat Rev Immunol 3:280-91
year: 2003

UnificationXref2012
type: UnificationXref
id: 72084
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72084

RelationshipXref160
type: RelationshipXref
id: GO:0043225
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2013
type: UnificationXref
id: REACT_5393
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5393.1

RelationshipXref161
type: RelationshipXref
id: 3649543
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649543

UnificationXref2014
type: UnificationXref
id: 29428
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29428

Ensembl:DDB0188724
type: ProteinReference
xref: UnificationXref6393
organism: Dictyostelium discoideum

RelationshipXref162
type: RelationshipXref
id: GO:0008559
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2015
type: UnificationXref
id: REACT_3913
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3913.3

RelationshipXref163
type: RelationshipXref
id: 3649566
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649566

UnificationXref2016
type: UnificationXref
id: 3642682
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642682

RelationshipXref164
type: RelationshipXref
id: GO:0005395
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2017
type: UnificationXref
id: 3642683
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642683

RelationshipXref165
type: RelationshipXref
id: 3649574
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649574

UnificationXref2018
type: UnificationXref
id: REACT_108007
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108007.9

RelationshipXref166
type: RelationshipXref
id: GO:0055085
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2019
type: UnificationXref
id: 111341
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111341

GUCA1C:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2321
component stoichiometry: Stoichiometry2322
component: Protein2589
component: SmallMolecule22
xref: UnificationXref11408
cellular location: GO:0097381
comment: Reactome DB_ID: 3651432

RelationshipXref168
type: RelationshipXref
id: 3645913
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645913

UBA2:SAE1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2324
component stoichiometry: Stoichiometry2323
component: Protein2606
component: Protein2605
xref: UnificationXref11446
cellular location: GO:0005654
comment: Reactome DB_ID: 3651512

RelationshipXref167
type: RelationshipXref
id: GO:0015171
db: GENE ONTOLOGY
relationship type: MI:0355

GUCA1A:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2317
component stoichiometry: Stoichiometry2318
component: Protein2577
component: SmallMolecule22
xref: UnificationXref11406
cellular location: GO:0097381
comment: Reactome DB_ID: 3651430

GUCA1B:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2320
component stoichiometry: Stoichiometry2319
component: Protein2583
component: SmallMolecule22
xref: UnificationXref11407
cellular location: GO:0097381
comment: Reactome DB_ID: 3651431

RelationshipXref169
type: RelationshipXref
id: 3645916
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3645916

ATP6V0 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2331
component stoichiometry: Stoichiometry2342
component stoichiometry: Stoichiometry2336
component stoichiometry: Stoichiometry2334
component stoichiometry: Stoichiometry2337
component: ATP6V0D (name copied from entity in Homo sapiens)
component: ATP6V0C hexamer (name copied from entity in Homo sapiens)
component: ATP6V0A (name copied from entity in Homo sapiens)
component: ATP6V0E (name copied from entity in Homo sapiens)
component: Protein2617
xref: UnificationXref11488
cellular location: GO:0030670
comment: Reactome DB_ID: 3649247

UnificationXref4390
type: UnificationXref
id: REACT_5885
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5885.1

ATP6V0E (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2330
component stoichiometry: Stoichiometry2329
component: PhysicalEntity273
component: PhysicalEntity272
xref: UnificationXref11476
cellular location: GO:0030670
comment: Reactome DB_ID: 3649246

http://identifiers.org/pubmed/6434534
type: PublicationXref
id: 6434534
author: Gracy, RW
author: Yuan, PM
author: Lu, HS
db: Pubmed
title: Primary structure of human triosephosphate isomerase
source: J Biol Chem 259:11958-68
year: 1984

SUMO1 S-glycyl-cys173 UBA2:SAE1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2326
component stoichiometry: Stoichiometry2325
component: Protein2606
component: Protein2607
xref: UnificationXref11449
cellular location: GO:0005654
comment: Reactome DB_ID: 3651519

UnificationXref2011
type: UnificationXref
id: 3642680
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642680

V-ATPase (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2343
component stoichiometry: Stoichiometry2344
component: ATP6V1 (name copied from entity in Homo sapiens)
component: ATP6V0 (name copied from entity in Homo sapiens)
xref: UnificationXref11489
cellular location: GO:0030670
comment: Reactome DB_ID: 3649248

UnificationXref2010
type: UnificationXref
id: 3641972
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641972

UnificationXref4394
type: UnificationXref
id: CHEBI:18077
db: ChEBI

UnificationXref4393
type: UnificationXref
id: REACT_4670
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4670.1

ATP6V0D (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2332
component stoichiometry: Stoichiometry2333
component: Protein2615
component: Protein2614
xref: UnificationXref11479
cellular location: GO:0030670
comment: Reactome DB_ID: 3649243

UnificationXref4392
type: UnificationXref
id: 29892
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29892

ATP6V0C hexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2335
component: Protein2616
xref: UnificationXref11481
cellular location: GO:0030670
comment: Reactome DB_ID: 3649240

UnificationXref4391
type: UnificationXref
id: CHEBI:16497
db: ChEBI

UnificationXref4398
type: UnificationXref
id: 29604
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29604

UnificationXref4397
type: UnificationXref
id: CHEBI:16284
db: ChEBI

http://identifiers.org/pubmed/15274629
type: PublicationXref
id: 15274629
author: Takeuchi, N
author: Heck, A
author: Spencer, AC
author: Watanabe, K
author: Spremulli, LL
db: Pubmed
title: Characterization of the human mitochondrial methionyl-tRNA synthetase
source: Biochemistry 43:9743-54
year: 2004

UnificationXref4396
type: UnificationXref
id: REACT_2773
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2773.1

UnificationXref4395
type: UnificationXref
id: 30187
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30187

http://identifiers.org/pubmed/7354069
type: PublicationXref
id: 7354069
author: Anderson, PM
author: Desnick, RJ
db: Pubmed
title: Purification and properties of uroporphyrinogen I synthase from human erythrocytes. Identification of stable enzyme-substrate intermediates.
source: J Biol Chem 255:1993-9
year: 1980

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54VA2
data source: Provenance1
name: Q54VA2
name: Fumarase
name: fumarate hydratase
name: Fumarate hydratase, mitochondrial
xref: UnificationXref8058
feature: FragmentFeature1639
cellular location: GO:0005759
comment: Reactome DB_ID: 3640610
display name: FH

UnificationXref8330
type: UnificationXref
id: 3642497
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642497

UnificationXref8331
type: UnificationXref
id: 3642498
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642498

UnificationXref8332
type: UnificationXref
id: 3642499
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642499

UnificationXref2080
type: UnificationXref
id: 3651880
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651880

UnificationXref8333
type: UnificationXref
id: 3642501
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642501

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q55AI5
data source: Provenance1
name: Succinyl-CoA synthetase, betaA chain
name: Q55AI5
xref: UnificationXref8036
feature: FragmentFeature1635
cellular location: GO:0005759
comment: Reactome DB_ID: 3640639
display name: SUCLA2

UnificationXref8334
type: UnificationXref
id: REACT_87638
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87638.9

SDHA
type: Protein
entity reference: Q9U3X4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Flavoprotein subunit of complex II
name: Succinate Dehydrogenase complex subunit A
name: Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial
name: Q9U3X4
xref: UnificationXref8045
feature: FragmentFeature1636
cellular location: GO:0005743
comment: Reactome DB_ID: 3640617
display name: Fp

UnificationXref8335
type: UnificationXref
id: 3651793
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651793

Succinate dehydrogenase (ubiquinone) iron-sulfur protein, mitochondrial
type: Protein
entity reference: Q55CC2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SDHB
name: Q55CC2
name: Succinate Dehydrogenase complex subunit B
name: Iron-sulfur subunit of complex II
xref: UnificationXref8050
feature: FragmentFeature1637
cellular location: GO:0005743
comment: Reactome DB_ID: 3640622
display name: Ip

UnificationXref8336
type: UnificationXref
id: REACT_156642
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156642.3

Succinate Dehydrogenase complex subunit C
type: Protein
entity reference: UniProt:Q8T2T5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Succinate dehydrogenase complex subunit C
name: CYBL
name: QPS1
name: Q8T2T5
name: Succinate-ubiquinone oxidoreductase cytochrome B large subunit
name: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor
name: Integral membrane protein CII-3
name: QPs-1
xref: UnificationXref8053
feature: FragmentFeature1638
cellular location: GO:0005743
comment: Reactome DB_ID: 3640627
display name: SDHC

UnificationXref2085
type: UnificationXref
id: 3641292
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641292

UnificationXref2086
type: UnificationXref
id: Q55E68
db: UniProt

UnificationXref2087
type: UnificationXref
id: 3641291
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641291

UnificationXref2088
type: UnificationXref
id: 3641294
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641294

UnificationXref2081
type: UnificationXref
id: REACT_159441
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159441.3

UnificationXref2082
type: UnificationXref
id: Q54J73
db: UniProt

UnificationXref2083
type: UnificationXref
id: 3641283
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641283

UnificationXref2084
type: UnificationXref
id: 3641293
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641293

SequenceSite2700
type: SequenceSite
position status: EQUAL
sequence position: 529

SequenceSite2701
type: SequenceSite
position status: EQUAL
sequence position: 122

SequenceSite2702
type: SequenceSite
position status: EQUAL
sequence position: 311

SequenceSite2703
type: SequenceSite
position status: EQUAL
sequence position: 122

UnificationXref2089
type: UnificationXref
id: 3641295
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641295

UnificationXref4309
type: UnificationXref
id: REACT_156963
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156963.3

UniProt:Q55DB4
type: ProteinReference
xref: UnificationXref9500
organism: Dictyostelium discoideum

UnificationXref4308
type: UnificationXref
id: 3640124
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640124

UnificationXref8338
type: UnificationXref
id: REACT_82354
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82354.9

Q54YZ4
type: Protein
entity reference: Q54YZ4
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Electron Transfer Flavoprotein beta subunit
name: ETF-beta
xref: UnificationXref8114
feature: FragmentFeature1642
cellular location: GO:0005759
comment: Reactome DB_ID: 3643819
display name: ETFB

UnificationXref4307
type: UnificationXref
id: REACT_3468
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3468.1

UnificationXref8337
type: UnificationXref
id: 3651783
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651783

Q54GJ7
type: Protein
entity reference: Q54GJ7
data source: Provenance1
xref: UnificationXref8092
cellular location: GO:0005759
comment: Reactome DB_ID: 3648348

UnificationXref4306
type: UnificationXref
id: 113518
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113518

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54XM6
data source: Provenance1
name: Q54XM6
xref: UnificationXref8124
feature: FragmentFeature1643
cellular location: GO:0005759
comment: Reactome DB_ID: 3643827
display name: ETFDH

UnificationXref4305
type: UnificationXref
id: REACT_142444
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142444.5

UnificationXref8339
type: UnificationXref
id: CHEBI:17672
db: ChEBI

Q54FD7
type: Protein
entity reference: Q54FD7
data source: Provenance1
xref: UnificationXref8116
cellular location: GO:0005759
comment: Reactome DB_ID: 3643815

UnificationXref4304
type: UnificationXref
id: 3644290
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644290

UnificationXref4303
type: UnificationXref
id: 3640157
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640157

UnificationXref4302
type: UnificationXref
id: 3640156
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640156

http://identifiers.org/pubmed/17331073
type: PublicationXref
id: 17331073
author: Wei, Y
author: Hornemann, T
author: von Eckardstein, A
db: Pubmed
title: Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?
source: Biochem J 405:157-64
year: 2007

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0305158
data source: Provenance1
name: DDB0305158
name: D-2-hydroxyglutarate dehydrogenase
xref: UnificationXref8077
feature: FragmentFeature1641
cellular location: GO:0005759
comment: Reactome DB_ID: 3648354
display name: D2HGDH

UnificationXref4301
type: UnificationXref
id: 3640155
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640155

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q55GI5
data source: Provenance1
name: L-2-hydroxyglutarate dehydrogenase
name: Q55GI5
xref: UnificationXref8070
feature: FragmentFeature1640
cellular location: GO:0005743
comment: Reactome DB_ID: 3648364
display name: L2HGDH

UnificationXref4300
type: UnificationXref
id: REACT_154776
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154776.3

UnificationXref8342
type: UnificationXref
id: P20054
db: UniProt

UnificationXref8343
type: UnificationXref
id: 3641793
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641793

UnificationXref8340
type: UnificationXref
id: 111647
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111647

Q55BI2
type: Protein
entity reference: Q55BI2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Isocitrate dehydrogenase (NAD) subunit alpha, mitochondrial precursor
name: isocitrate dehydrogenase 3 (NAD+) alpha
name: NAD+-specific ICDH
name: Isocitric dehydrogenase
xref: UnificationXref8002
feature: FragmentFeature1628
cellular location: GO:0005759
comment: Reactome DB_ID: 3640584
display name: IDH3A

UnificationXref8341
type: UnificationXref
id: REACT_2904
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2904.2

isocitrate dehydrogenase 3 (NAD+) gamma
type: Protein
entity reference: Q54B68
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Isocitrate dehydrogenase (NAD) subunit gamma, mitochondrial precursor
name: NAD+-specific ICDH
name: Isocitric dehydrogenase
name: Q54B68
xref: UnificationXref8005
feature: FragmentFeature1629
cellular location: GO:0005759
comment: Reactome DB_ID: 3640589
display name: IDH3G

UnificationXref8346
type: UnificationXref
id: REACT_89432
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89432.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54XS2
data source: Provenance1
name: aconitase 2, mitochondrial
name: Q54XS2
name: Aconitase
name: Aconitate hydratase, mitochondrial precursor
name: Citrate hydro-lyase
xref: UnificationXref7994
feature: FragmentFeature1626
cellular location: GO:0005759
comment: Reactome DB_ID: 3640597
display name: ACO2

UnificationXref8347
type: UnificationXref
id: CHEBI:15859
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54B68
data source: Provenance1
name: NAD+-specific ICDH
name: Isocitrate dehydrogenase (NAD) subunit beta, mitochondrial precursor
name: isocitrate dehydrogenase 3 (NAD+) beta
name: Isocitric dehydrogenase
name: Q54B68
xref: UnificationXref8000
feature: FragmentFeature1627
cellular location: GO:0005759
comment: Reactome DB_ID: 3640588
display name: IDH3B

UnificationXref8344
type: UnificationXref
id: 3641794
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641794

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P36413
data source: Provenance1
name: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
name: ODP2_HUMAN
name: PBC
name: pyruvate dehydrogenase E2 subunit
name: PDC-E2
name: P36413
name: 2xLipo-DLAT
name: M2 antigen complex 70 kDa subunit
name: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor
name: 70 kDa mitochondrial autoantigen of primary biliary cirrhosis
xref: UnificationXref7979
feature: FragmentFeature1624
feature: ModificationFeature198
feature: ModificationFeature199
cellular location: GO:0005759
comment: Reactome DB_ID: 3640840
display name: E2

RelationshipXref109
type: RelationshipXref
id: GO:0004693
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref8345
type: UnificationXref
id: 3641800
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641800

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q553V1
data source: Provenance1
name: Q553V1
name: Citrate synthase, mitochondrial precursor
name: citrate synthase
xref: UnificationXref7987
feature: FragmentFeature1625
cellular location: GO:0005759
comment: Reactome DB_ID: 3640603
display name: CS

UnificationXref2076
type: UnificationXref
id: 3651878
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651878

RelationshipXref107
type: RelationshipXref
id: 3650947
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3650947

UnificationXref2077
type: UnificationXref
id: REACT_155796
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155796.3

RelationshipXref108
type: RelationshipXref
id: GO:0007092
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/7354072
type: PublicationXref
id: 7354072
author: Bodlaender, P
author: Shemin, D
author: Bevan, DR
db: Pubmed
title: Mechanism of porphobilinogen synthase. Requirement of Zn2+ for enzyme activity.
source: J Biol Chem 255:2030-5
year: 1980

UnificationXref2074
type: UnificationXref
id: 3642731
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642731

RelationshipXref105
type: RelationshipXref
id: GO:0031018
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2075
type: UnificationXref
id: REACT_156055
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156055.3

RelationshipXref106
type: RelationshipXref
id: GO:0016301
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2072
type: UnificationXref
id: 3642729
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642729

RelationshipXref103
type: RelationshipXref
id: 3648149
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648149

UnificationXref2073
type: UnificationXref
id: 3642730
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642730

RelationshipXref104
type: RelationshipXref
id: GO:0007411
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/8128219
type: PublicationXref
id: 8128219
author: Tonks, N K
author: Flint, A J
author: Barford, D
db: Pubmed
title: Crystal structure of human protein tyrosine phosphatase 1B
source: Science 263:1397-404
year: 1994

UnificationXref2070
type: UnificationXref
id: O76494
db: UniProt

RelationshipXref101
type: RelationshipXref
id: 3649230
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649230

UnificationXref2071
type: UnificationXref
id: 3642728
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642728

RelationshipXref102
type: RelationshipXref
id: GO:0019221
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref100
type: RelationshipXref
id: GO:0045087
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref2079
type: UnificationXref
id: REACT_159131
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159131.3

UnificationXref2078
type: UnificationXref
id: 3651879
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651879

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q869S7
data source: Provenance1
name: Q869S7
name: Succinyl-CoA synthetase, betaG chain
xref: UnificationXref8031
feature: FragmentFeature1634
cellular location: GO:0005759
comment: Reactome DB_ID: 3640923
display name: SUCLG2

UniProt:Q6RZZ9
type: ProteinReference
xref: UnificationXref5112
organism: Dictyostelium discoideum

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P36967
data source: Provenance1
name: SUCLG1(28-333)
name: Succinyl-CoA synthetase, alpha-chain
xref: UnificationXref8029
feature: FragmentFeature1633
cellular location: GO:0005759
comment: Reactome DB_ID: 3640635
display name: P36967

UnificationXref8349
type: UnificationXref
id: REACT_3042
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3042.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54JE4
data source: Provenance1
name: 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor
name: 2-oxoglutarate dehydrogenase E1
name: Q54JE4
name: ODO1_HUMAN
name: Alpha-ketoglutarate dehydrogenase
name: alpha-ketoglutarate dehydrogenase E1 apoenzyme
xref: UnificationXref8022
feature: FragmentFeature1632
cellular location: GO:0005759
comment: Reactome DB_ID: 3640680
display name: OGDH

UnificationXref8348
type: UnificationXref
id: 111628
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111628

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q869Y7
data source: Provenance1
name: alpha-ketoglutarate dehydrogenase E2
name: Q869Y7
name: Dihydrolipoamide succinyltransferase
name: Lipo-DLST
xref: UnificationXref8016
feature: FragmentFeature1631
feature: ModificationFeature200
cellular location: GO:0005759
comment: Reactome DB_ID: 3640687
display name: DLST

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0231372
data source: Provenance1
name: DDB0231372
name: NAD
name: nicotinamide nucleotide transhydrogenase
xref: UnificationXref8011
feature: FragmentFeature1630
cellular location: GO:0005743
comment: Reactome DB_ID: 3647876
display name: NNT

UniProt:Q8T2J9
type: ProteinReference
xref: UnificationXref8851
organism: Dictyostelium discoideum

UniProt:Q55DC0
type: ProteinReference
xref: UnificationXref1344
organism: Dictyostelium discoideum

UnificationXref8311
type: UnificationXref
id: 3642187
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642187

UnificationXref8312
type: UnificationXref
id: 3642189
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642189

UnificationXref8313
type: UnificationXref
id: REACT_77127
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77127.9

UnificationXref8314
type: UnificationXref
id: CHEBI:17712
db: ChEBI

N-glycan trimming in the ER and Calnexin/Calreticulin cycle
type: Pathway
data source: Provenance1
pathway component: Calnexin/calreticulin cycle
pathway component: BiochemicalReaction1183
evidence: Evidence1893
xref: RelationshipXref1432
xref: UnificationXref12877
xref: UnificationXref12876
pathway order: PathwayStep1858
pathway order: PathwayStep1847
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref8310
type: UnificationXref
id: 3642186
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642186

RelationshipXref112
type: RelationshipXref
id: 3651201
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651201

SequenceSite2716
type: SequenceSite
position status: EQUAL
sequence position: 1185

UnificationXref2060
type: UnificationXref
id: 3642665
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642665

RelationshipXref113
type: RelationshipXref
id: 3651143
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651143

SequenceSite2715
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2061
type: UnificationXref
id: 3642681
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642681

RelationshipXref114
type: RelationshipXref
id: GO:0007062
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite2718
type: SequenceSite
position status: EQUAL
sequence position: 1234

UnificationXref2062
type: UnificationXref
id: REACT_32256
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32256.10

RelationshipXref115
type: RelationshipXref
id: 3651286
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651286

SequenceSite2717
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref2063
type: UnificationXref
id: 3642666
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642666

RelationshipXref116
type: RelationshipXref
id: GO:0004721
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2064
type: UnificationXref
id: REACT_83429
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83429.9

RelationshipXref117
type: RelationshipXref
id: 2529016
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2529016

SequenceSite2719
type: SequenceSite
position status: EQUAL
sequence position: 2

http://identifiers.org/pubmed/10681399
type: PublicationXref
id: 10681399
author: Harris, RC
author: Capdevila, JH
author: Falck, JR
db: Pubmed
title: Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase
source: J Lipid Res 41:163-81
year: 2000

UnificationXref2065
type: UnificationXref
id: 3651865
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651865

RelationshipXref118
type: RelationshipXref
id: GO:0000236
db: GENE ONTOLOGY
relationship type: MI:0359

O-linked glycosylation of mucins
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1199
pathway component: BiochemicalReaction1198
pathway component: BiochemicalReaction1201
pathway component: BiochemicalReaction1200
evidence: Evidence1909
xref: UnificationXref12998
xref: UnificationXref12997
xref: RelationshipXref1517
pathway order: PathwayStep1872
pathway order: PathwayStep1871
pathway order: PathwayStep1874
pathway order: PathwayStep1873
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref2066
type: UnificationXref
id: 77601
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77601

RelationshipXref119
type: RelationshipXref
id: GO:0008234
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref2068
type: UnificationXref
id: Q6TMI9
db: UniProt

UnificationXref2067
type: UnificationXref
id: REACT_4094
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4094.2

SequenceSite2720
type: SequenceSite
position status: EQUAL
sequence position: 1175

UnificationXref2069
type: UnificationXref
id: 3642727
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642727

SequenceSite2721
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2722
type: SequenceSite
position status: EQUAL
sequence position: 608

SequenceSite2723
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref111
type: RelationshipXref
id: GO:0000088
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite2724
type: SequenceSite
position status: EQUAL
sequence position: 756

RelationshipXref110
type: RelationshipXref
id: 3644073
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644073

SequenceSite2725
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8319
type: UnificationXref
id: 3642194
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642194

UnificationXref8316
type: UnificationXref
id: REACT_3957
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3957.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54C70
data source: Provenance1
name: ODPA_HUMAN
name: Q54C70
name: pyruvate dehydrogenase E1 alpha apoprotein
name: Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor
name: PDHE1-A type I
xref: UnificationXref7969
feature: FragmentFeature1621
cellular location: GO:0005759
comment: Reactome DB_ID: 3640829
display name: PDHA1

UnificationXref8315
type: UnificationXref
id: 30064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30064

Q54EW8
type: Protein
entity reference: Q54EW8
data source: Provenance1
name: Glycine cleavage system L protein
name: Note: the coordinates are copied over from Homo sapiens.
name: Dihydrolipoamide dehydrogenase, mitochondrial
xref: UnificationXref7965
feature: FragmentFeature1620
cellular location: GO:0005759
comment: Reactome DB_ID: 3640423
display name: DLD

UnificationXref8318
type: UnificationXref
id: 3642193
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642193

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q86AD5
data source: Provenance1
name: proX
name: E3-binding protein
name: Pyruvate dehydrogenase protein X component, mitochondrial precursor
name: E3BP
name: ODPX_HUMAN
name: Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex
name: pyruvate dehydrogenase complex X component (E3 binding protein)
name: Q86AD5
xref: UnificationXref7976
feature: FragmentFeature1623
cellular location: GO:0005759
comment: Reactome DB_ID: 3640845
display name: PDHX

http://identifiers.org/pubmed/12515382
type: PublicationXref
id: 12515382
author: Arndt-Jovin, DJ
author: Ingelfinger, D
author: Achsel, T
author: Lührmann, R
db: Pubmed
title: The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci
source: RNA 8:1489-501
year: 2002

UnificationXref8317
type: UnificationXref
id: Q86AW9
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q86HX0
data source: Provenance1
name: Pyruvate dehydrogenase E1 component beta subunit, mitochondrial precursor
name: ODPA_HUMAN
name: PDHE1-B
name: Q86HX0
name: pyruvate dehydrogenase E1 beta apoprotein
xref: UnificationXref7971
feature: FragmentFeature1622
cellular location: GO:0005759
comment: Reactome DB_ID: 3640833
display name: PDHB

UnificationXref8324
type: UnificationXref
id: REACT_2530
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2530.1

UnificationXref8325
type: UnificationXref
id: 113535
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113535

UnificationXref8322
type: UnificationXref
id: CHEBI:16240
db: ChEBI

UnificationXref8323
type: UnificationXref
id: 113575
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113575

UnificationXref8320
type: UnificationXref
id: 3642196
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642196

UnificationXref8321
type: UnificationXref
id: REACT_30688
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30688.10

UnificationXref2050
type: UnificationXref
id: 3640931
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640931

RelationshipXref125
type: RelationshipXref
id: GO:0004651
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite2707
type: SequenceSite
position status: EQUAL
sequence position: 315

UnificationXref2051
type: UnificationXref
id: 3640936
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640936

RelationshipXref126
type: RelationshipXref
id: 3642685
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642685

SequenceSite2706
type: SequenceSite
position status: EQUAL
sequence position: 556

Regulation of mitotic cell cycle
type: Pathway
data source: Provenance1
pathway component: REACT 107295.9
evidence: Evidence634
xref: UnificationXref4716
xref: UnificationXref4715
pathway order: PathwayStep619
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

RelationshipXref123
type: RelationshipXref
id: GO:0000910
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite2705
type: SequenceSite
position status: EQUAL
sequence position: 315

RelationshipXref124
type: RelationshipXref
id: GO:0000087
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite2704
type: SequenceSite
position status: EQUAL
sequence position: 311

UnificationXref2054
type: UnificationXref
id: 3640997
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640997

RelationshipXref129
type: RelationshipXref
id: 3642692
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642692

UnificationXref2055
type: UnificationXref
id: 3640998
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640998

UnificationXref2052
type: UnificationXref
id: 72085
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72085

RelationshipXref127
type: RelationshipXref
id: GO:0004484
db: GENE ONTOLOGY
relationship type: MI:0355

SequenceSite2709
type: SequenceSite
position status: EQUAL
sequence position: 29

UnificationXref2053
type: UnificationXref
id: REACT_3987
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3987.1

RelationshipXref128
type: RelationshipXref
id: 3642689
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642689

SequenceSite2708
type: SequenceSite
position status: EQUAL
sequence position: 556

UnificationXref2059
type: UnificationXref
id: REACT_93299
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93299.9

UnificationXref2058
type: UnificationXref
id: 3642696
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642696

SequenceSite2710
type: SequenceSite
position status: EQUAL
sequence position: 677

UnificationXref2057
type: UnificationXref
id: REACT_114145
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114145.8

UnificationXref2056
type: UnificationXref
id: 3642697
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642697

UniProt:Q55DA0
type: ProteinReference
xref: UnificationXref2631
organism: Dictyostelium discoideum

RelationshipXref122
type: RelationshipXref
id: 3643439
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643439

SequenceSite2713
type: SequenceSite
position status: EQUAL
sequence position: 1

RelationshipXref121
type: RelationshipXref
id: GO:0000090
db: GENE ONTOLOGY
relationship type: MI:0359

SequenceSite2714
type: SequenceSite
position status: EQUAL
sequence position: 1216

UniProt:Q55DA2
type: ProteinReference
xref: UnificationXref10376
organism: Dictyostelium discoideum

RelationshipXref120
type: RelationshipXref
id: 3651165
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary3
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651165

SequenceSite2711
type: SequenceSite
position status: EQUAL
sequence position: 59

SequenceSite2712
type: SequenceSite
position status: EQUAL
sequence position: 743

UnificationXref8329
type: UnificationXref
id: O77229
db: UniProt

UnificationXref8328
type: UnificationXref
id: REACT_4475
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4475.1

UniProt:Q9GSG9
type: ProteinReference
xref: UnificationXref1293
organism: Dictyostelium discoideum

UnificationXref8327
type: UnificationXref
id: 113569
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113569

UnificationXref8326
type: UnificationXref
id: REACT_5022
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5022.2

UnificationXref8370
type: UnificationXref
id: CHEBI:17625
db: ChEBI

SequenceSite2737
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2738
type: SequenceSite
position status: EQUAL
sequence position: 762

UnificationXref8372
type: UnificationXref
id: REACT_22071
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22071.1

SequenceSite2739
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8371
type: UnificationXref
id: 500739
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500739

UnificationXref8374
type: UnificationXref
id: 500742
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500742

UnificationXref4343
type: UnificationXref
id: 3651943
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651943

UnificationXref8373
type: UnificationXref
id: CHEBI:17622
db: ChEBI

UnificationXref4342
type: UnificationXref
id: REACT_155022
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155022.3

UnificationXref8376
type: UnificationXref
id: Q54BW5
db: UniProt

UnificationXref4341
type: UnificationXref
id: 3651944
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651944

UnificationXref8375
type: UnificationXref
id: REACT_21695
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21695.1

UnificationXref4340
type: UnificationXref
id: REACT_159430
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159430.3

UnificationXref8378
type: UnificationXref
id: 3641904
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641904

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P20425
data source: Provenance1
name: P20425
name: Deoxycytidylate kinase
name: UMP-CMP kinase
name: Cytidine monophosphate kinase
name: Cytidylate kinase
xref: UnificationXref8504
feature: FragmentFeature1676
cellular location: GO:0005829
comment: Reactome DB_ID: 3641778
display name: CMPK1

UnificationXref8377
type: UnificationXref
id: 3641903
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641903

UnificationXref8379
type: UnificationXref
id: 3641906
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641906

SASP
type: Protein
entity reference: Q54KN7
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: Q54KN7
name: ATL-derived factor
name: thioredoxin, oxidized
name: 2xHC-TXN
name: Surface associated sulphydryl protein
xref: UnificationXref8546
feature: ModificationFeature203
feature: FragmentFeature1682
feature: ModificationFeature204
cellular location: GO:0005654
comment: Reactome DB_ID: 3642956
display name: ADF

SASP
type: Protein
entity reference: P29447
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: ATL-derived factor
name: thioredoxin, oxidized
name: 2xHC-TXN
name: P29447
name: Surface associated sulphydryl protein
xref: UnificationXref8547
feature: FragmentFeature1683
feature: ModificationFeature206
feature: ModificationFeature205
cellular location: GO:0005654
comment: Reactome DB_ID: 3642959
display name: ADF

Homologues of TXN
type: Protein
data source: Provenance1
member physical entity: SASP
xref: UnificationXref8554
cellular location: GO:0005654
comment: Reactome DB_ID: 3642950
comment: Converted from EntitySet in Reactome

UnificationXref4348
type: UnificationXref
id: REACT_105551
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105551.9

SASP
type: Protein
entity reference: Q1ZXE0
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: ATL-derived factor
name: ADF
name: Q1ZXE0
name: Surface associated sulphydryl protein
xref: UnificationXref8551
feature: FragmentFeature1684
cellular location: GO:0005654
comment: Reactome DB_ID: 3642947
display name: TXN

UnificationXref4349
type: UnificationXref
id: 3643881
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643881

CTP synthase 2
type: Protein
entity reference: Q54V77
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q54V77
xref: UnificationXref8533
feature: FragmentFeature1679
cellular location: GO:0005829
comment: Reactome DB_ID: 3648024
display name: CTPS2

UnificationXref4346
type: UnificationXref
id: REACT_107492
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107492.9

glutathione reductase
type: Protein
entity reference: UniProt:Q8T137
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: GSR isoform 2
name: GSR-2
name: GRase
name: Q8T137
name: GSHR_HUMAN
name: Glutathione reductase, mitochondrial precursor
xref: UnificationXref8541
feature: FragmentFeature1680
cellular location: GO:0005829
comment: Reactome DB_ID: 3640908
display name: GR

UnificationXref4347
type: UnificationXref
id: 3651697
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651697

Homologues of 2xHC-TXN
type: Protein
data source: Provenance1
member physical entity: SASP
xref: UnificationXref8548
cellular location: GO:0005654
comment: Reactome DB_ID: 3642960
comment: Converted from EntitySet in Reactome

UnificationXref4344
type: UnificationXref
id: REACT_101076
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101076.9

SASP
type: Protein
entity reference: Q1ZXE0
data source: Provenance1
name: Thioredoxin
name: Note: the coordinates are copied over from Homo sapiens.
name: ATL-derived factor
name: thioredoxin, oxidized
name: 2xHC-TXN
name: Q1ZXE0
name: Surface associated sulphydryl protein
xref: UnificationXref8545
feature: FragmentFeature1681
feature: ModificationFeature202
feature: ModificationFeature201
cellular location: GO:0005654
comment: Reactome DB_ID: 3642953
display name: ADF

UnificationXref4345
type: UnificationXref
id: 3651696
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651696

SequenceSite2745
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2744
type: SequenceSite
position status: EQUAL
sequence position: 1573

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54GN2
data source: Provenance1
name: dTMP kinase
name: deoxythymidylate kinase (thymidylate kinase)
name: Thymidylate kinase
name: DTYMK(2-212)
xref: UnificationXref8522
feature: FragmentFeature1677
cellular location: GO:0005829
comment: Reactome DB_ID: 3641866
display name: Q54GN2

SequenceSite2747
type: SequenceSite
position status: EQUAL
sequence position: 1

UTP--ammonia ligase
type: Protein
entity reference: Q54V77
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: CTP synthase
name: Q54V77
name: CTP synthetase
xref: UnificationXref8529
feature: FragmentFeature1678
cellular location: GO:0005829
comment: Reactome DB_ID: 3641896
display name: CTPS1

SequenceSite2746
type: SequenceSite
position status: EQUAL
sequence position: 416

SequenceSite2741
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2740
type: SequenceSite
position status: EQUAL
sequence position: 762

SequenceSite2743
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2742
type: SequenceSite
position status: EQUAL
sequence position: 1258

UnificationXref8383
type: UnificationXref
id: 500759
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500759

SequenceSite2728
type: SequenceSite
position status: EQUAL
sequence position: 789

UnificationXref8382
type: UnificationXref
id: REACT_30611
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30611.10

SequenceSite2729
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref8381
type: UnificationXref
id: 3651772
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651772

SequenceSite2726
type: SequenceSite
position status: EQUAL
sequence position: 2302

UnificationXref8380
type: UnificationXref
id: REACT_76954
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_76954.9

SequenceSite2727
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8387
type: UnificationXref
id: Q8T154
db: UniProt

UnificationXref4330
type: UnificationXref
id: REACT_2843
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2843.2

UnificationXref8386
type: UnificationXref
id: REACT_21421
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21421.1

UnificationXref8385
type: UnificationXref
id: 500761
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500761

UnificationXref4332
type: UnificationXref
id: REACT_28980
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28980.10

UnificationXref8384
type: UnificationXref
id: REACT_21676
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21676.1

UnificationXref4331
type: UnificationXref
id: 3643271
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643271

UnificationXref8389
type: UnificationXref
id: 3641843
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641843

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54BW5
data source: Provenance1
name: deoxyuridine triphosphatase isoform 2
name: Q54BW5
name: dUTP pyrophosphatase
xref: UnificationXref8377
feature: FragmentFeature1666
cellular location: GO:0005654
comment: Reactome DB_ID: 3641903
display name: DUT-2

UnificationXref8388
type: UnificationXref
id: 3641842
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641842

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P09556
data source: Provenance1
name: Orotate phosphoribosyltransferase
name: UMPS(2-480)
name: OMPdecase
name: OPRtase
name: UMP synthase
name: uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)
name: Uridine 5'-monophosphate synthase
name: P09556
name: Uridine 5'-monophosphate synthase (UMP synthase) (Includes: Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRtase); Orotidine 5'- phosphate decarboxylase (EC 4.1.1.23) (OMPdecase))
name: Orotidine 5'- phosphate decarboxylase
xref: UnificationXref8364
feature: FragmentFeature1665
cellular location: GO:0005829
comment: Reactome DB_ID: 3641784
display name: UMPS

Q54QJ9
type: Protein
entity reference: Q54QJ9
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenylate kinase isoenzyme 2, mitochondrial
name: adenylate kinase 2
name: ATP-AMP transphosphorylase
name: Adenylate kinase isoenzyme 2, mitochondrial (EC 2.7.4.3) (ATP-AMP transphosphorylase)
xref: UnificationXref8469
feature: FragmentFeature1674
cellular location: GO:0005758
comment: Reactome DB_ID: 3642837
display name: AK2

UnificationXref4337
type: UnificationXref
id: REACT_152952
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152952.3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54XF2
data source: Provenance1
name: Guanylate kinase (EC 2.7.4.8) (GMP kinase)
name: Q54XF2
name: GMP kinase
name: guanylate kinase 1
xref: UnificationXref8482
feature: FragmentFeature1675
cellular location: GO:0005829
comment: Reactome DB_ID: 3641977
display name: GUK1

UnificationXref4338
type: UnificationXref
id: 3643276
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643276

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q55DL0
data source: Provenance1
name: Dihydropyrimidinase
name: Hydantoinase
name: DPYS
name: DHPase
name: Q55DL0
xref: UnificationXref8436
feature: FragmentFeature1672
cellular location: GO:0005829
comment: Reactome DB_ID: 3641828
display name: DHP

UnificationXref4339
type: UnificationXref
id: 3643277
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643277

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q964D8
data source: Provenance1
name: N-carbamoyl-beta-alanine amidohydrolase
name: BUP-1
name: Beta-alanine synthase
name: Q964D8
name: Beta-ureidopropionase
xref: UnificationXref8444
feature: FragmentFeature1673
cellular location: GO:0005829
comment: Reactome DB_ID: 3641835
display name: UPB1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54I82
data source: Provenance1
name: Q54I82
name: Cytidine deaminase
name: Cytidine aminohydrolase
xref: UnificationXref8414
feature: FragmentFeature1670
cellular location: GO:0005829
comment: Reactome DB_ID: 3641849
display name: CDA

UnificationXref4333
type: UnificationXref
id: 3651942
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651942

UniProt:Q8T2F3
type: ProteinReference
xref: UnificationXref10354
organism: Dictyostelium discoideum

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q55FT1
data source: Provenance1
name: Q55FT1
name: Dihydropyrimidine dehydrogenase (NADP+)
name: DHPDHase
name: Dihydrouracil dehydrogenase
name: Dihydrothymine dehydrogenase
xref: UnificationXref8425
feature: FragmentFeature1671
cellular location: GO:0005829
comment: Reactome DB_ID: 3641821
display name: DPYD

UnificationXref4334
type: UnificationXref
id: REACT_114637
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114637.8

Uridine monophosphokinase 2
type: Protein
entity reference: UniProt:Q8T154
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cytidine monophosphokinase 2
name: Q8T154
name: Uridine-cytidine kinase 2
name: UCK2(2-261)
xref: UnificationXref8392
feature: FragmentFeature1668
cellular location: GO:0005829
comment: Reactome DB_ID: 3642786
display name: UCK 2

UnificationXref4335
type: UnificationXref
id: 3643274
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643274

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q27564
data source: Provenance1
name: Thymidine kinase, cytosolic
name: TK1(1-234)
name: Thymidine kinase, cytosolic (EC 2.7.1.21)
name: thymidine kinase 1, soluble
xref: UnificationXref8399
feature: FragmentFeature1669
cellular location: GO:0005829
comment: Reactome DB_ID: 3641859
display name: Q27564

UnificationXref4336
type: UnificationXref
id: 3643275
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643275

SequenceSite2736
type: SequenceSite
position status: EQUAL
sequence position: 1416

UCK 1
type: Protein
entity reference: UniProt:Q8T154
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Uridine monophosphokinase 1
name: Cytidine monophosphokinase 1
name: Q8T154
name: Uridine-cytidine kinase 1
xref: UnificationXref8388
feature: FragmentFeature1667
cellular location: GO:0005829
comment: Reactome DB_ID: 3641842
display name: UCK1

SequenceSite2735
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2734
type: SequenceSite
position status: EQUAL
sequence position: 1693

SequenceSite2733
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2732
type: SequenceSite
position status: EQUAL
sequence position: 1265

SequenceSite2731
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2730
type: SequenceSite
position status: EQUAL
sequence position: 1290

SequenceSite2759
type: SequenceSite
position status: EQUAL
sequence position: 31

UnificationXref8350
type: UnificationXref
id: 3641798
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641798

UnificationXref8356
type: UnificationXref
id: REACT_32516
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32516.10

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54DD0
data source: Provenance1
name: Q54DD0
name: AMP deaminase 3
name: Erythrocyte AMP deaminase
name: AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase)
name: AMP deaminase isoform E
name: erythrocyte AMP deaminase
xref: UnificationXref8262
feature: FragmentFeature1656
cellular location: GO:0005829
comment: Reactome DB_ID: 3642659
display name: AMPD3

UnificationXref8355
type: UnificationXref
id: 3641796
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641796

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54DD0
data source: Provenance1
name: Q54DD0
name: AMP deaminase isoform L
name: AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L)
name: AMP deaminase 2
xref: UnificationXref8260
feature: FragmentFeature1655
cellular location: GO:0005829
comment: Reactome DB_ID: 3642657
display name: AMPD2

UnificationXref8358
type: UnificationXref
id: 76632
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76632

UnificationXref8357
type: UnificationXref
id: CHEBI:16742
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54KF3
data source: Provenance1
name: Adenosine deaminase-like protein
name: Q54KF3
xref: UnificationXref8273
feature: FragmentFeature1657
cellular location: GO:0005829
comment: Reactome DB_ID: 3650800
display name: ADAL

UnificationXref8352
type: UnificationXref
id: CHEBI:17025
db: ChEBI

UnificationXref4321
type: UnificationXref
id: 68422
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=68422

UnificationXref8351
type: UnificationXref
id: REACT_96047
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96047.9

UnificationXref4320
type: UnificationXref
id: REACT_107132
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107132.9

UnificationXref8354
type: UnificationXref
id: REACT_4914
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4914.1

UnificationXref8353
type: UnificationXref
id: 76630
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76630

Homologues of APRT
type: Protein
data source: Provenance1
member physical entity: Adenine phosphoribosyltransferase
xref: UnificationXref8281
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3642166

UnificationXref4324
type: UnificationXref
id: 68424
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=68424

Adenine phosphoribosyltransferase
type: Protein
entity reference: Q55C82
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q55C82
xref: UnificationXref8278
feature: FragmentFeature1658
cellular location: GO:0005829
comment: Reactome DB_ID: 3642161
display name: APRT

UnificationXref4325
type: UnificationXref
id: REACT_2531
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2531.1

Adenine phosphoribosyltransferase
type: Protein
entity reference: Ensembl:DDB0187721
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: DDB0187721
xref: UnificationXref8280
feature: FragmentFeature1659
cellular location: GO:0005829
comment: Reactome DB_ID: 3642165
display name: APRT

UnificationXref4322
type: UnificationXref
id: REACT_3288
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3288.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54NJ8
data source: Provenance1
name: HGPRTase
name: Hypoxanthine-guanine phosphoribosyltransferase
name: Q54NJ8
name: HGPRT
xref: UnificationXref8290
feature: FragmentFeature1660
cellular location: GO:0005829
comment: Reactome DB_ID: 3642173
display name: HPRT1

UnificationXref4323
type: UnificationXref
id: 3639820
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639820

UnificationXref8359
type: UnificationXref
id: REACT_5211
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5211.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54XC1
data source: Provenance1
name: Q54XC1
name: cytosolic purine 5'-nucleotidase
name: high Km 5'-nucleotidase
name: Cytosolic purine 5'-nucleotidase
name: 5'-nucleotidase cytosolic II
xref: UnificationXref8310
feature: FragmentFeature1661
cellular location: GO:0005829
comment: Reactome DB_ID: 3642186
display name: NT5C2

UnificationXref4328
type: UnificationXref
id: REACT_3748
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3748.1

Removal of licensing factors from origins
type: Pathway
data source: Provenance1
pathway component: REACT 96221.9
pathway component: REACT 28463.10
pathway component: BiochemicalReaction325
evidence: Evidence596
xref: UnificationXref4552
xref: UnificationXref4551
pathway order: PathwayStep557
pathway order: PathwayStep556
pathway order: PathwayStep552
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

Q86AW9
type: Protein
entity reference: Q86AW9
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: GAH
name: Guanase
name: Guanine deaminase
name: p51-nedasin
name: Guanine aminohydrolase
name: Guanine aminase
xref: UnificationXref8318
feature: FragmentFeature1662
cellular location: GO:0005829
comment: Reactome DB_ID: 3642193
display name: GDA

UnificationXref4329
type: UnificationXref
id: 113656
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113656

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O77229
data source: Provenance1
name: O77229
name: Catalase apoprotein (EC 1.11.1.6)
name: Catalase
name: CATA_HUMAN
xref: UnificationXref8330
feature: FragmentFeature1663
cellular location: GO:0005782
comment: Reactome DB_ID: 3642497
display name: CAT

UnificationXref4326
type: UnificationXref
id: 3640046
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640046

SequenceSite2761
type: SequenceSite
position status: EQUAL
sequence position: 31

P20054
type: Protein
entity reference: UniProt:P20054
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Aspartate carbamoyltransferase
name: Dihydroorotase
name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
name: CAD protein (Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3))
name: Glutamine-dependent carbamoyl-phosphate synthase
xref: UnificationXref8343
feature: FragmentFeature1664
cellular location: GO:0005829
comment: Reactome DB_ID: 3641793
display name: CAD

UnificationXref4327
type: UnificationXref
id: 113499
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113499

SequenceSite2760
type: SequenceSite
position status: EQUAL
sequence position: 487

SequenceSite2763
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2762
type: SequenceSite
position status: EQUAL
sequence position: 487

SequenceSite2765
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2764
type: SequenceSite
position status: EQUAL
sequence position: 277

SequenceSite2767
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2766
type: SequenceSite
position status: EQUAL
sequence position: 288

SequenceSite2769
type: SequenceSite
position status: EQUAL
sequence position: 22

SequenceSite2768
type: SequenceSite
position status: EQUAL
sequence position: 558

UnificationXref8361
type: UnificationXref
id: 111629
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111629

UnificationXref2095
type: UnificationXref
id: 3641301
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641301

UnificationXref8360
type: UnificationXref
id: CHEBI:15842
db: ChEBI

UnificationXref2094
type: UnificationXref
id: 3641300
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641300

UnificationXref2093
type: UnificationXref
id: 3641299
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641299

SequenceSite2748
type: SequenceSite
position status: EQUAL
sequence position: 491

UnificationXref2092
type: UnificationXref
id: Q54N48
db: UniProt

SequenceSite2749
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2099
type: UnificationXref
id: 3641274
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641274

UnificationXref2098
type: UnificationXref
id: DDB0233706
db: Ensembl

UnificationXref2097
type: UnificationXref
id: 3641270
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641270

G-protein mediated events
type: Pathway
data source: Provenance1
pathway component: Adenylate cyclase inhibitory pathway
pathway component: REACT 30880.10
evidence: Evidence1630
xref: UnificationXref11274
xref: UnificationXref11273
pathway order: PathwayStep384
pathway order: PathwayStep1605
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref2096
type: UnificationXref
id: DDB0233705
db: Ensembl

UnificationXref8369
type: UnificationXref
id: REACT_86723
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86723.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q86L14
data source: Provenance1
name: Inosinicase
name: Bifunctional purine biosynthesis protein PURH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP synthetase) (ATIC))
name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
name: IMP cyclohydrolase
name: Bifunctional purine biosynthesis protein PURH
name: Q86L14
name: IMP synthetase
name: AICAR transformylase
name: Phosphoribosylaminoimidazolecarboxamide formyltransferase
xref: UnificationXref8195
feature: FragmentFeature1647
cellular location: GO:0005829
comment: Reactome DB_ID: 3641997
display name: ATIC

UnificationXref8368
type: UnificationXref
id: 3641787
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641787

FGAM synthase
type: Protein
entity reference: Q54JC8
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: FGAMS
name: Formylglycinamide ribotide synthetase
name: Phosphoribosylformylglycinamidine synthase
name: Formylglycinamide ribotide amidotransferase
name: Q54JC8
name: FGARAT
xref: UnificationXref8180
feature: FragmentFeature1646
cellular location: GO:0005829
comment: Reactome DB_ID: 3642012
display name: PFAS

UnificationXref8367
type: UnificationXref
id: REACT_81573
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81573.9

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
type: Protein
entity reference: Q54GJ2
data source: Provenance1
name: GAR transformylase
name: Trifunctional purine biosynthetic protein adenosine-3 (Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase))
name: Trifunctional purine biosynthetic protein adenosine-3
name: GARS
name: AIRS
name: 5'-phosphoribosylglycinamide transformylase
name: Phosphoribosylamine--glycine ligase
name: Glycinamide ribonucleotide synthetase
name: Note: the coordinates are copied over from Homo sapiens.
name: AIR synthase
name: Phosphoribosylformylglycinamidine cyclo-ligase
name: Phosphoribosylglycinamide formyltransferase
name: Q54GJ2
name: Phosphoribosyl-aminoimidazole synthetase
name: GART(2-1010)
name: Phosphoribosylglycinamide synthetase
xref: UnificationXref8162
feature: FragmentFeature1645
cellular location: GO:0005829
comment: Reactome DB_ID: 3642006
display name: GART

UnificationXref8366
type: UnificationXref
id: 3641789
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641789

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q86A85
data source: Provenance1
name: GPAT
name: Glutamine phosphoribosylpyrophosphate amidotransferase
name: Amidophosphoribosyltransferase precursor (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (GPAT)
name: ATASE
name: Amidophosphoribosyltransferase precursor
name: phosphoribosyl pyrophosphate amidotransferase
name: Q86A85
name: glutamine phosphoribosylpyrophosphate amidotransferase
name: amidophosphoribosyltransferase
xref: UnificationXref8137
feature: FragmentFeature1644
cellular location: GO:0005829
comment: Reactome DB_ID: 3642022
display name: PPAT

UnificationXref8365
type: UnificationXref
id: 3641785
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641785

UnificationXref2091
type: UnificationXref
id: 3641287
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641287

UnificationXref8364
type: UnificationXref
id: 3641784
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641784

UnificationXref2090
type: UnificationXref
id: Q54ZS8
db: UniProt

UnificationXref8363
type: UnificationXref
id: P09556
db: UniProt

UnificationXref4310
type: UnificationXref
id: 3651707
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651707

UnificationXref8362
type: UnificationXref
id: REACT_3215
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3215.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P32073
data source: Provenance1
name: guanine monophosphate synthetase
name: Glutamine amidotransferase
name: GMP synthetase
name: P32073
name: GMP synthase (glutamine-hydrolyzing)
xref: UnificationXref8211
feature: FragmentFeature1649
cellular location: GO:0005829
comment: Reactome DB_ID: 3641983
display name: GMPS

UnificationXref4311
type: UnificationXref
id: REACT_103160
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103160.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P21900
data source: Provenance1
name: IMP--aspartate ligase 1
name: AMPSase 1
name: P21900
name: Adenylosuccinate synthetase isozyme 1
name: AdSS 1
name: adenylosuccinate synthetase 1
name: adenylosuccinate synthetase like 1
xref: UnificationXref8218
feature: FragmentFeature1650
cellular location: GO:0005829
comment: Reactome DB_ID: 3642934
display name: ADSSL1

UnificationXref4312
type: UnificationXref
id: 3643273
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643273

UnificationXref4313
type: UnificationXref
id: 3639854
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639854

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54QQ0
data source: Provenance1
name: IMP (inosine monophosphate) dehydrogenase 1
name: Inosine-5'-monophosphate dehydrogenase 1 (EC 1.1.1.205) (IMP dehydrogenase 1) (IMPDH-I) (IMPD 1)
name: IMP dehydrogenase 1
name: IMPDH-I
name: Inosine-5'-monophosphate dehydrogenase 1
name: Q54QQ0
name: IMPD 1
xref: UnificationXref8205
feature: FragmentFeature1648
cellular location: GO:0005829
comment: Reactome DB_ID: 3641989
display name: IMPDH1

UnificationXref4314
type: UnificationXref
id: Q54LA0
db: UniProt

Adenosine kinase
type: Protein
entity reference: Q54MB5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q54MB5
name: ADK(2-362)
name: Adenosine 5'-phosphotransferase
xref: UnificationXref8253
feature: FragmentFeature1653
cellular location: GO:0005829
comment: Reactome DB_ID: 3642758
display name: AK

UnificationXref4315
type: UnificationXref
id: 3648087
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648087

SequenceSite2750
type: SequenceSite
position status: EQUAL
sequence position: 441

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54DD0
data source: Provenance1
name: AMP deaminase 1 (EC 3.5.4.6) (Myoadenylate deaminase) (AMP deaminase isoform M)
name: Q54DD0
name: Myoadenylate deaminase
name: AMP deaminase isoform M
name: myoadenylate deaminase
name: AMP deaminase 1
xref: UnificationXref8258
feature: FragmentFeature1654
cellular location: GO:0005829
comment: Reactome DB_ID: 3642655
display name: AMPD1

UnificationXref4316
type: UnificationXref
id: 3648088
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648088

IMP--aspartate ligase 2
type: Protein
entity reference: P21900
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P21900
name: Adenylosuccinate synthetase (EC 6.3.4.4) (IMP--aspartate ligase) (AdSS) (AMPSase)
name: ADSS(2-456)
name: AMPSase 2
name: Adenylosuccinate synthetase 2
name: adenylosuccinate synthetase
xref: UnificationXref8221
feature: FragmentFeature1651
cellular location: GO:0005829
comment: Reactome DB_ID: 3642937
display name: AdSS 2

UnificationXref4317
type: UnificationXref
id: 3648089
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648089

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54KF3
data source: Provenance1
name: Adenosine aminohydrolase
name: Q54KF3
name: Adenosine deaminase
xref: UnificationXref8247
feature: FragmentFeature1652
cellular location: GO:0005829
comment: Reactome DB_ID: 3642180
display name: ADA

UnificationXref4318
type: UnificationXref
id: REACT_83562
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83562.9

UnificationXref4319
type: UnificationXref
id: 3652215
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652215

SequenceSite2754
type: SequenceSite
position status: EQUAL
sequence position: 491

SequenceSite2753
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2752
type: SequenceSite
position status: EQUAL
sequence position: 426

SequenceSite2751
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2758
type: SequenceSite
position status: EQUAL
sequence position: 410

SequenceSite2757
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2756
type: SequenceSite
position status: EQUAL
sequence position: 441

SequenceSite2755
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9045610
type: PublicationXref
id: 9045610
author: Weaver, PL
author: Chuang, RY
author: Chang, TH
author: Liu, Z
db: Pubmed
title: Requirement of the DEAD-Box protein ded1p for messenger RNA translation.
source: Science 275:1468-71
year: 1997

Apoptotic execution phase
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction991
pathway component: REACT 127192.5
pathway component: BiochemicalReaction992
evidence: Evidence1502
xref: RelationshipXref1322
xref: UnificationXref10434
xref: UnificationXref10435
pathway order: PathwayStep1480
pathway order: PathwayStep1481
pathway order: PathwayStep1482
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref8400
type: UnificationXref
id: 3641860
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641860

UnificationXref8402
type: UnificationXref
id: REACT_108769
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108769.9

UnificationXref8401
type: UnificationXref
id: 3641862
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641862

UnificationXref6618
type: UnificationXref
id: REACT_109094
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_109094.9

UnificationXref6619
type: UnificationXref
id: CHEBI:27505
db: ChEBI

http://identifiers.org/pubmed/3129195
type: PublicationXref
id: 3129195
author: Baeuerle, PA
author: Baltimore, D
db: Pubmed
title: Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor
source: Cell 53:211-7
year: 1988

UnificationXref8403
type: UnificationXref
id: CHEBI:15698
db: ChEBI

UnificationXref6610
type: UnificationXref
id: 3644495
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644495

UnificationXref8404
type: UnificationXref
id: 109379
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109379

UnificationXref6611
type: UnificationXref
id: 3644496
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644496

UniProt:Q55GS6
type: ProteinReference
xref: UnificationXref9292
organism: Dictyostelium discoideum

UnificationXref8405
type: UnificationXref
id: REACT_3054
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3054.2

UnificationXref6612
type: UnificationXref
id: 3644498
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644498

UnificationXref8406
type: UnificationXref
id: 500829
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500829

UnificationXref6613
type: UnificationXref
id: REACT_78952
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78952.9

UnificationXref8407
type: UnificationXref
id: REACT_21803
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21803.1

UnificationXref6614
type: UnificationXref
id: CHEBI:28047
db: ChEBI

UnificationXref8408
type: UnificationXref
id: CHEBI:16450
db: ChEBI

UnificationXref6615
type: UnificationXref
id: 192030
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192030

UnificationXref8409
type: UnificationXref
id: 109383
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109383

UnificationXref6616
type: UnificationXref
id: REACT_10392
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10392.1

UnificationXref6617
type: UnificationXref
id: 3644500
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644500

UnificationXref6620
type: UnificationXref
id: 192342
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192342

SequenceSite2802
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2801
type: SequenceSite
position status: EQUAL
sequence position: 278

SequenceSite2800
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref6629
type: UnificationXref
id: REACT_10685
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10685.1

http://identifiers.org/pubmed/18772396
type: PublicationXref
id: 18772396
author: Zhang, X
author: Shinjo, SM
author: Rasheed, BA
author: Lin, JC
author: Carter, H
author: Jones, S
author: Keir, S
author: Parmigiani, G
author: Yan, H
author: McLendon, R
author: Olivi, A
author: Nikolsky, Y
author: Diaz Jr, LA
author: Tekleab, H
author: Vogelstein, B
author: Kinzler, KW
author: Velculescu, VE
author: Papadopoulos, N
author: Mankoo, P
author: Marie, SK
author: Parsons, DW
author: Busam, DA
author: Riggins, GJ
author: Bigner, DD
author: Karchin, R
author: Hartigan, J
author: Angenendt, P
author: Leary, RJ
author: Smith, DR
author: Strausberg, RL
author: Gallia, GL
author: Siu, IM
author: Nikolskaya, T
db: Pubmed
title: An integrated genomic analysis of human glioblastoma multiforme
source: Science 321:1807-12
year: 2008

UnificationXref6623
type: UnificationXref
id: 193422
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193422

http://identifiers.org/pubmed/17035995
type: PublicationXref
id: 17035995
author: De Camilli, P
author: Di Paolo, G
db: Pubmed
title: Phosphoinositides in cell regulation and membrane dynamics
source: Nature 443:651-7
year: 2006

UnificationXref6624
type: UnificationXref
id: REACT_10198
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10198.1

UnificationXref6621
type: UnificationXref
id: REACT_10191
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10191.2

UnificationXref6622
type: UnificationXref
id: CHEBI:52050
db: ChEBI

UnificationXref6627
type: UnificationXref
id: CHEBI:27393
db: ChEBI

UnificationXref6628
type: UnificationXref
id: 193459
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193459

UnificationXref6625
type: UnificationXref
id: 3644507
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644507

UnificationXref6626
type: UnificationXref
id: REACT_31955
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31955.10

UnificationXref8422
type: UnificationXref
id: 70986
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70986

UnificationXref8421
type: UnificationXref
id: REACT_2801
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2801.1

Evidence1009
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14527956
comment: At the Golgi membrane, phosphatidylinositide phosphatase SAC1 (SACM1L) dephosphorylates phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol (PI) but not as efficiently as phosphatidylinositol 4-phosphate (PI4P) dephosphorylation. No significant activity of this enzyme towards phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) was detected (Rohde et al. 2003).

UnificationXref8424
type: UnificationXref
id: Q55FT1
db: UniProt

Evidence1008
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7628435
xref: http://identifiers.org/pubmed/8999962
xref: http://identifiers.org/pubmed/10766823
xref: http://identifiers.org/pubmed/10805725
comment: At the Golgi membrane, phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) aka VPS34 is bound to phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4). This PIK3C3:PIK2R4 complex and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 3-phosphate (PI3P). The following lists the above proteins with their corresponding literature references: PIK3C3:PIK2R4 (Panaretou et al. 1997, Volinia et al. 1995) and PIK3C2A (Arcaro et al. 2000, Domin et al. 2000).

UnificationXref6631
type: UnificationXref
id: 193388
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193388

UnificationXref8423
type: UnificationXref
id: REACT_5528
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5528.1

Evidence1007
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14527956
comment: At the Golgi membrane, phosphatidylinositide phosphatase SAC1 (SACM1L) efficiently dephosphorylates phosphatidylinositol 4-phosphate (PI4P), and to a lesser extent phosphatidylinositol 3-phosphate (PI3P), to phosphatidylinositol (PI). No significant activity of this enzyme towards phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) was detected (Rohde et al. 2003).

UnificationXref6630
type: UnificationXref
id: CHEBI:27403
db: ChEBI

Evidence1006
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9405935
comment: At the Golgi membrane, activated phosphatidylinositol 4-kinase beta (PI4KB) complexed to ADP-ribosylation factor 1/3 (ARF1/3) phosphorylates phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) (Suzuki et al. 1997).

Evidence1005
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9148941
xref: http://identifiers.org/pubmed/10559940
xref: http://identifiers.org/pubmed/17555535
comment: At the Golgi membrane, ADP-ribosylation factor 1 and 3 (ARF1 and ARF3) complexed to GTP bind to phosphatidylinositol 4-kinase beta (PI4KB) and activate it (Haynes et al. 2007, Wong et al. 1997, Godi et al. 1999).

Downstream Signaling Events Of B Cell Receptor (BCR)
type: Pathway
data source: Provenance1
pathway component: REACT 149199.4
pathway component: REACT 154383.3
pathway component: REACT 159808.3
evidence: Evidence76
xref: UnificationXref631
xref: UnificationXref630
pathway order: PathwayStep71
pathway order: PathwayStep59
pathway order: PathwayStep62
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref8420
type: UnificationXref
id: 73584
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73584

Evidence1004
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10101268
xref: http://identifiers.org/pubmed/11923287
xref: http://identifiers.org/pubmed/11279162
xref: http://identifiers.org/pubmed/10559940
xref: http://identifiers.org/pubmed/12324459
comment: At the Golgi membrane, phosphatidylinositol 4-kinase alpha (PI4KA) (Gehrmann et al. 1999, Godi et al. 1999), or phosphatidylinositol 4-kinase type 2-alpha/beta (PI4K2A/B) (Balla et al. 2002, Minogue et al. 2001, Wei et al. 2002) phosphorylate phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P).

Evidence1003
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10101268
xref: http://identifiers.org/pubmed/9148941
xref: http://identifiers.org/pubmed/14527956
xref: http://identifiers.org/pubmed/12324459
comment: At the endoplasmic reticulum (ER) membrane, phosphatidylinositol (PI) and phosphatidylinositol 4-phosphate (PI4P) are interconverted (Wong et al. 1997, Gehrmann et al. 1999, Wei et al. 2002, Rohde et al. 2003).

Evidence1002
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14527956
comment: At the endoplasmic reticulum (ER) membrane, transmembrane protein phosphatidylinositide phosphatase SAC1 (SACM1L) efficiently dephosphorylates phosphatidylinositol 4-phosphate (PI4P), and to a lesser extent phosphatidylinositol 3-phosphate (PI3P), to phosphatidylinositol (PI). No significant activity of this enzyme towards phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) was detected (Rohde et al. 2003).

Evidence1001
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10101268
xref: http://identifiers.org/pubmed/9148941
xref: http://identifiers.org/pubmed/12324459
comment: At the endoplasmic reticulum (ER) membrane, phosphatidylinositol 4-kinase alpha (PI4KA) (Wong et al. 1997, Gehrmann et al. 1999) or phosphatidylinositol 4-kinase type 2-beta (PI4K2B) (Wei et al. 2002) phosphorylate phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P).

Evidence1000
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/21704024
xref: http://identifiers.org/pubmed/21683693
xref: PublicationXref1838
xref: http://identifiers.org/pubmed/20823909
xref: http://identifiers.org/pubmed/19703651
xref: http://identifiers.org/pubmed/21220505
xref: http://identifiers.org/pubmed/21382416
comment: Glycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids act as precursors of lipid mediators such as platelet-activating factor and eicosanoids. Cellular membranes contains a distinct composition of various glycerophospholipids such as phosphatidic acid (PA), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylglycerol (PG), phosphatidylinositol (PI), cardiolipin (CL), lysophosphatidic acid (LPA) and lysobisphosphatidic acid (also known as bis(monoacylglycerol) hydrogen phosphate - BMP). Glycerophospholipids are first formed by the de novo (Kennedy) pathway using fatty acids activated as acyl-CoA donors. However, the acyl groups of glycerophospholipids are highly diverse and distributed in an asymmetric manner. Saturated and monounsaturated fatty acids are usually esterified at the sn-1 position, whereas polyunsaturated acyl groups are esterified at the sn-2 position. Subsequent acyl chain remodeling (Lands cycle) generates the diverse glycerophospholipid composition and asymmetry characteristic of cell membranes. In the de novo pathway of glycerophospholipid biosynthesis, lysophosphatidic acid (LPA) is initially formed from glycerol 3-phosphate (G3P). Next, LPA is converted to PA by a LPA acyltransferase (AGPAT, also known as LPAAT), then PA is metabolized into two types of glycerol derivatives. The first is diacylglycerol (DAG) which is converted to triacylglycerol (TAG), PC, and PE. Subsequently, PS is synthesized from PC or PE. The second is cytidine diphosphate-diacylglycerol (CDP-DAG), which is processed into PI, PG, CL, and BMP. Each glycerophospholipid is involved in acyl chain remodeling via cleavage by phospholipases followed by reacylation by an acyltransferase. Most of the glycerophospholipids are synthesized at the endoplasmic reticulum (ER), however, some, most notably c…

UnificationXref8429
type: UnificationXref
id: 3641822
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641822

UnificationXref6636
type: UnificationXref
id: 192339
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192339

UnificationXref6637
type: UnificationXref
id: REACT_10827
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10827.1

UnificationXref6638
type: UnificationXref
id: 3644541
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644541

UnificationXref6639
type: UnificationXref
id: REACT_99860
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99860.9

UnificationXref8425
type: UnificationXref
id: 3641821
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641821

UnificationXref6632
type: UnificationXref
id: REACT_10857
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10857.1

UnificationXref8426
type: UnificationXref
id: CHEBI:17621
db: ChEBI

UnificationXref6633
type: UnificationXref
id: 3644543
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644543

Regulation of the Fanconi anemia pathway
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction283
evidence: Evidence495
xref: UnificationXref4116
xref: UnificationXref4117
pathway order: PathwayStep482
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref8427
type: UnificationXref
id: 73524
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73524

UnificationXref6634
type: UnificationXref
id: REACT_84955
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_84955.9

UnificationXref8428
type: UnificationXref
id: REACT_3399
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3399.2

UnificationXref6635
type: UnificationXref
id: CHEBI:27379
db: ChEBI

http://identifiers.org/pubmed/2040271
type: PublicationXref
id: 2040271
author: Sadahiro, S
author: Matsuda, T
author: Takenaka, M
author: Tanaka, T
author: Noguchi, T
author: Hirai, H
author: Imai, E
author: Yamada, K
db: Pubmed
title: Isolation and characterization of the human pyruvate kinase M gene
source: Eur J Biochem 198:101-6
year: 1991

UnificationXref8413
type: UnificationXref
id: Q54I82
db: UniProt

Evidence1019
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16914545
xref: http://identifiers.org/pubmed/17008356
xref: http://identifiers.org/pubmed/12646134
xref: http://identifiers.org/pubmed/14660569
xref: http://identifiers.org/pubmed/11733541
xref: http://identifiers.org/pubmed/12118066
xref: http://identifiers.org/pubmed/15840652
xref: http://identifiers.org/pubmed/11676921
xref: http://identifiers.org/pubmed/11302699
xref: http://identifiers.org/pubmed/10224048
xref: http://identifiers.org/pubmed/17651088
comment: At the plasma membrane, synaptojanin-1 aka Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1) (Guo et al. 1999), -2 (SYNJ2) and some myotubularins (MTMs) dephosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol (PI). The MTMs involved are: myotubularin (MTM1) (Cao et al. 2007, Tronchere et al. 2004, Schaletzky et al. 2003, Laporte et al. 2002, Kim et al. 2002) and myotubularin-related proteins 1 (MTMR1) (Kim et al. 2002, Tronchere et al. 2004), 3 (MTMR3) (Kim et al. 2002, Zhao et al. 2001, Walker et al. 2001, Lorenzo et al. 2005), 6 (MTMR6) (Schaletzky et al. 2003, Kim et al. 2002, Choudhury et al. 2006), and 14 (MTMR14) (Tosch et al. 2006).

UnificationXref6642
type: UnificationXref
id: REACT_10890
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10890.1

UnificationXref8412
type: UnificationXref
id: REACT_21686
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21686.1

Evidence1018
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9660759
xref: http://identifiers.org/pubmed/11604140
xref: http://identifiers.org/pubmed/9211928
xref: http://identifiers.org/pubmed/9367159
xref: http://identifiers.org/pubmed/19896968
xref: http://identifiers.org/pubmed/12422219
xref: http://identifiers.org/pubmed/18753295
comment: At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) and beta (PIP4K2B) homodimers and heterodimers (Clarke et al. 2010), along with phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). The following lists the above proteins with their corresponding literature references: PIP4K2A (Zhang et al. 1997, Rameh et al. 1997, Clarke et al. 2008), PIP4K2B (Zhang et al. 1997, Rameh et al. 1997), PIP5K1A (Zhang et al. 1997, Tolias et al. 1998), PIP5K1B (Zhang et al. 1997, Tolias et al. 1998), and PIP5K1C (Wenk et al. 2001, Di Paolo et al. 2002).

UnificationXref6641
type: UnificationXref
id: 193403
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193403

UnificationXref8411
type: UnificationXref
id: 500430
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500430

UnificationXref6640
type: UnificationXref
id: CHEBI:28533
db: ChEBI

UniProt:Q55GT5
type: ProteinReference
xref: UnificationXref12187
organism: Dictyostelium discoideum

UnificationXref8410
type: UnificationXref
id: REACT_3530
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3530.2

Evidence1015
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9660759
xref: http://identifiers.org/pubmed/11604140
xref: http://identifiers.org/pubmed/9211928
xref: http://identifiers.org/pubmed/12422219
xref: http://identifiers.org/pubmed/12847086
comment: At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) to produce phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3). This is a minor reaction, however, and its physiological role is uncertain. The following lists the above proteins with their corresponding literature references: PIP5K1A (Zhang et al. 1997, Tolias et al. 1998), PIP5K1B (Zhang et al. 1997, Tolias et al. 1998), and PIP5K1C (Wenk et al. 2001, Di Paolo et al. 2002, Krauss et al. 2003).

Evidence1014
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12536145
xref: http://identifiers.org/pubmed/18093523
xref: http://identifiers.org/pubmed/10753883
xref: http://identifiers.org/pubmed/10593988
xref: http://identifiers.org/pubmed/9428629
xref: http://identifiers.org/pubmed/10224048
xref: http://identifiers.org/pubmed/11084340
xref: http://identifiers.org/pubmed/15080793
comment: At the plasma membrane, Synaptojanin-1 (SYNJ1) and -2 (SYNJ2), inositol polyphosphate 5-phosphatase K (INPP5K) aka SKIP, phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) aka PIPP dephosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to form phosphatidylinositol 4-phosphate (PI4P). SYNJ1/2 both have an N-terminal Sac1-like domain, a central 5-phosphatase domain and a C-terminal proline-rich segment, with this latter part being the most divergent part of the protein sequence. The following lists the above proteins with their corresponding literature references: SYNJ1 (Johenning et al. 2004, Haffner et al. 1997, Guo et al. 1999, Mani et al. 2007), SYNJ2 (Malecz et al. 2000), INPP5K (Injuin et al. 2000, Gurung et al. 2003), and INPP5J (Gurung et al. 2003, Mochizuki & Takenawa 1999).

Evidence1017
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12808147
xref: http://identifiers.org/pubmed/9811831
comment: At the plasma membrane, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase aka phosphatase and tensin homolog (PTEN) dephosphorylates phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) to phosphatidylinositol 4-phosphate (PI4P) (Myers et al. 1998, Das et al. 2003).

Evidence1016
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9660833
xref: http://identifiers.org/pubmed/12536145
xref: http://identifiers.org/pubmed/11349134
xref: http://identifiers.org/pubmed/10822173
xref: http://identifiers.org/pubmed/10753883
xref: http://identifiers.org/pubmed/8769125
xref: http://identifiers.org/pubmed/10593988
xref: http://identifiers.org/pubmed/10194451
xref: http://identifiers.org/pubmed/8723348
comment: At the plasma membrane, phosphatidylinositol 5-phosphatases dephosphorylate phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). The phosphatidylinositol 5-phosphatases involved are: inositol polyphosphate 5-phosphatase K (INPP5K) aka SKIP (Ijuin et al. 2000, Gurung et al. 2003), phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) aka PIPP (Gurung et al. 2003, Mochizuki & Takenawa 1999), phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) aka SHIP1 (Drayer et al. 1995, Kavanaugh et al. 1996, Dunant et al. 2000), and phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) aka SHIP2 (Habib et al. 1998, Wisniewski et al. 1999, Pesesse et al. 2001).

Evidence1011
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18950639
xref: http://identifiers.org/pubmed/17556371
comment: At the Golgi membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger. The FIG4 phosphatase component dephosphorylates phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) (Sbrissa et al. 2007, Sbrissa et al. 2008).

Evidence1010
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10419465
xref: http://identifiers.org/pubmed/18950639
xref: http://identifiers.org/pubmed/11706043
xref: http://identifiers.org/pubmed/10567352
xref: http://identifiers.org/pubmed/17556371
comment: At the Golgi membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger (Sbrissa et al. 2002). The PIKFYVE kinase component phosphorylates phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,5-bisphosphate PI(3,5)P2 (Sbrissa et al. 1999, McEwen et al. 1999). The PAS complex is present in the cytosol and is recruited to the membrane (Sbrissa et al. 2007). VAC14 acts as a scaffolding protein via its C-terminal domain (Sbrissa et al. 2008).

Evidence1013
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15464023
xref: http://identifiers.org/pubmed/17245604
xref: http://identifiers.org/pubmed/9211928
xref: http://identifiers.org/pubmed/12422219
xref: http://identifiers.org/pubmed/16979564
comment: At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 4-phosphate (PI4P) to produce phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). The following lists the above proteins with their corresponding literature references: PIP5K1A (Halstead et al. 2006, Zhang et al. 1997), PIP5K1B (Zhang et al. 1997), and PIP5K1C (Di Paolo et al. 2002). This reaction is of particular interest because its regulation by small GTPases of the RHO and ARF families, not yet annotated here, ties the process of phosphatidylinositol phosphate biosynthesis to regulation of the actin cytoskeleton and vesicular trafficking, and hence to diverse aspects of cell motility and signalling (Oude Weernink et al., 2004, 2007).

Evidence1012
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11279162
xref: http://identifiers.org/pubmed/14527956
xref: http://identifiers.org/pubmed/18950639
xref: http://identifiers.org/pubmed/10559940
xref: http://identifiers.org/pubmed/10766823
xref: http://identifiers.org/pubmed/10805725
xref: http://identifiers.org/pubmed/17556371
comment: At the Golgi membrane, phosphatidylinositol 4-phosphate (PI4P) is primarily generated from phosphorylation of phosphatidylinositol (PI). Other phosphoinositides are also generated by the action of various kinases and phosphatases such as: phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Godi et al. 1999, Minogue et al. 2001, Rohde et al. 2003, Sbrissa et al. 2007, Sbrissa et al. 2008, Domin et al. 2000, Arcaro et al. 2000).

UnificationXref4506
type: UnificationXref
id: 3642370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642370

UnificationXref4507
type: UnificationXref
id: REACT_152864
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152864.3

UnificationXref4508
type: UnificationXref
id: 3651844
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651844

UnificationXref4509
type: UnificationXref
id: REACT_158931
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158931.3

UnificationXref6649
type: UnificationXref
id: REACT_10249
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10249.1

UnificationXref8418
type: UnificationXref
id: 3651776
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651776

UnificationXref4500
type: UnificationXref
id: REACT_79083
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79083.9

UnificationXref6647
type: UnificationXref
id: CHEBI:63839
db: ChEBI

UnificationXref8419
type: UnificationXref
id: REACT_78751
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78751.9

UnificationXref4501
type: UnificationXref
id: 3642366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642366

UnificationXref6648
type: UnificationXref
id: 193745
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193745

UnificationXref8416
type: UnificationXref
id: 3641852
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641852

UnificationXref4502
type: UnificationXref
id: 3642367
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642367

UnificationXref6645
type: UnificationXref
id: 3652034
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652034

UnificationXref8417
type: UnificationXref
id: REACT_81775
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81775.9

UnificationXref4503
type: UnificationXref
id: 3642368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642368

UnificationXref6646
type: UnificationXref
id: REACT_88402
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88402.9

UnificationXref8414
type: UnificationXref
id: 3641849
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641849

UnificationXref4504
type: UnificationXref
id: REACT_156510
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156510.3

UnificationXref6643
type: UnificationXref
id: 3644542
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644542

UnificationXref8415
type: UnificationXref
id: 3641850
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641850

UnificationXref4505
type: UnificationXref
id: 3642369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642369

UnificationXref6644
type: UnificationXref
id: REACT_102724
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102724.9

Evidence1020
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9660759
comment: At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A) and beta (PIP5K1B) phosphorylate phosphatidylinositol (PI) to produce phosphatidylinositol 5-phosphate (PI5P) (Tolias et al. 1998).

Evidence1023
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16914545
xref: http://identifiers.org/pubmed/17008356
xref: http://identifiers.org/pubmed/12646134
xref: http://identifiers.org/pubmed/14660569
xref: http://identifiers.org/pubmed/12118066
xref: http://identifiers.org/pubmed/15840652
xref: http://identifiers.org/pubmed/11676921
xref: http://identifiers.org/pubmed/10224048
xref: http://identifiers.org/pubmed/17651088
comment: At the plasma membrane, synaptojanin-1 aka Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1) (Guo et al. 1999), -2 (SYNJ2) and some myotubularins (MTMs) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P). The MTMs involved are: myotubularin (MTM1) (Cao et al. 2007, Tronchere et al. 2004, Schaletzky et al. 2003, Laporte et al. 2002) and myotubularin-related proteins 1 (MTMR1) (Tronchere et al. 2004), 3 (MTMR3) (Walker et al. 2001, Lorenzo et al. 2005), 6 (MTMR6) (Schaletzky et al. 2003, Choudhury et al. 2006), and 14 (MTMR14) (Tosch et al. 2006).

Evidence1024
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9367159
xref: http://identifiers.org/pubmed/19896968
xref: http://identifiers.org/pubmed/18753295
comment: At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) and beta (PIP4K2B) homodimers and heterodimers (Clarke et al. 2010) phosphorylate phosphatidylinositol 5-phosphate (PI5P) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). The following lists the above proteins with their corresponding literature references: PIP4K2A (Rameh et al. 1997, Clarke et al. 2008) and PIP4K2B (Rameh et al. 1997).

Evidence1021
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9660759
comment: At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A) and beta (PIP5K1B) phosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Tolias et al. 1998).

Evidence1022
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18093523
xref: http://identifiers.org/pubmed/10224048
xref: http://identifiers.org/pubmed/11084340
comment: At the plasma membrane, synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 aka synaptojanin-1 (SYNJ1) (Guo et al. 1999, Mani et al. 2007) and -2 (SYNJ2) (Malecz et al. 2000) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P).

Evidence1027
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10419465
xref: http://identifiers.org/pubmed/17651088
xref: http://identifiers.org/pubmed/11706043
xref: http://identifiers.org/pubmed/17556371
comment: At the early endosome membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger (Sbrissa et al. 2002, Cao et al. 2007). The PIKFYVE kinase component phosphorylates phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,5-bisphosphate PI(3,5)P2 (Sbrissa et al. 1999). The PAS complex is present in the cytosol and is recruited to the membrane (Sbrissa et al. 2007).

Evidence1028
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18950639
xref: http://identifiers.org/pubmed/17556371
comment: At the early endosome membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger. The FIG4 phosphatase component dephosphorylates phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) (Sbrissa et al. 2007, Sbrissa et al. 2008).

Evidence1025
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18093523
xref: http://identifiers.org/pubmed/10224048
xref: http://identifiers.org/pubmed/11084340
xref: http://identifiers.org/pubmed/15080793
comment: At the plasma membrane, synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 aka Synaptojanin-1 (SYNJ1) (Guo et al. 1999, Mani et al. 2007, Johenning et al. 2004) and -2 (SYNJ2) (Malecz et al. 2000) dephosphorylate phosphatidylinositol 4-phosphate (PI4P) phosphatidylinositol (PI). The SAC1 domains of SYNJ1 and SYNJ2 demonstrate 4-phosphatase activity.

Evidence1026
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9660759
xref: http://identifiers.org/pubmed/12646134
xref: http://identifiers.org/pubmed/12536145
xref: http://identifiers.org/pubmed/9113989
xref: http://identifiers.org/pubmed/9211928
xref: http://identifiers.org/pubmed/11733541
xref: http://identifiers.org/pubmed/19896968
xref: http://identifiers.org/pubmed/10224048
comment: At the plasma membrane, subsequent phosphorylation of phosphatidylinositol 4-phosphate (PI4P) produces phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) while the actions of various other kinases and phosphatases produces phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 5-phosphate (PI5P), phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Zhang et al. 1997, Gurung et al. 2003, Guo et al. 1999, Vanhaesebroeck et al. 1997, Tolias et al. 1998, Schaletzky et al. 2003, Kim et al. 2002, Clarke et al. 2010).

http://identifiers.org/pubmed/18989317
type: PublicationXref
id: 18989317
author: Unterholzner, L
author: Bowie, AG
db: Pubmed
title: Viral evasion and subversion of pattern-recognition receptor signalling
source: Nat Rev Immunol 8:911-22
year: 2008

http://identifiers.org/pubmed/3356695
type: PublicationXref
id: 3356695
author: Panniers, R
author: Rowlands, AG
author: Henshaw, EC
db: Pubmed
title: The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2.
source: J Biol Chem 263:5526-33
year: 1988

Evidence1029
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18524850
xref: http://identifiers.org/pubmed/17651088
xref: http://identifiers.org/pubmed/16787938
comment: At the early endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2) and myotubularin-related protein 4 (MTMR4) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P). The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008), MTMR2 (Cao et al. 2008), and MTMR4 (Lorenzo et al. 2006).

Ensembl:DDB0233655
type: ProteinReference
xref: UnificationXref92
organism: Dictyostelium discoideum

Ensembl:DDB0237970
type: ProteinReference
xref: UnificationXref124
organism: Dictyostelium discoideum

http://identifiers.org/pubmed/17402747
type: PublicationXref
id: 17402747
author: Magni, G
author: Franchetti, P
author: Cimadamore, F
author: Cappellacci, L
author: Orsomando, G
author: Scotti, S
author: Sorci, L
author: Petrelli, R
db: Pubmed
title: Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis
source: Biochemistry 46:4912-22
year: 2007

Evidence1030
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7628435
xref: http://identifiers.org/pubmed/17651088
xref: http://identifiers.org/pubmed/8999962
xref: http://identifiers.org/pubmed/10766823
xref: http://identifiers.org/pubmed/10805725
comment: At the early endosome membrane, phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) aka VPS34 binds to phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4). The PIK3C3:PIK3R4 complex and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 3-phosphate (PI3P). The following lists the above proteins with their corresponding literature references: PIK3C3:PIK3R4 complex (Panaretou et al. 1997, Volinia et al. 1995, Cao et al. 2007) and PIK3C2A (Arcaro et al. 2000, Domin et al. 2000).

Evidence1031
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11733541
xref: http://identifiers.org/pubmed/18524850
xref: http://identifiers.org/pubmed/11302699
xref: http://identifiers.org/pubmed/17651088
xref: http://identifiers.org/pubmed/16787938
comment: At the early endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2), and myotubularin-related protein 4 (MTMR4) dephosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol (PI). The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008, Kim et al. 2002), MTMR2 (Cao et al. 2008, Kim et al. 2002), and MTMR4 (Lorenzo et al. 2006, Zhao et al. 2001).

Evidence1032
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11733541
xref: http://identifiers.org/pubmed/18950639
xref: http://identifiers.org/pubmed/18524850
xref: http://identifiers.org/pubmed/17651088
xref: http://identifiers.org/pubmed/10805725
xref: http://identifiers.org/pubmed/17556371
comment: At the early endosome membrane, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is generated in two steps from phosphatidylinositol 3,4-bisphosphate PI(3,4)P2 by the action of various kinases and phosphatases (Sbrissa et al. 2007, Sbrissa et al. 2008, Cao et al. 2007, Cao et al. 2008, Arcaro et al. 2000, Kim et al. 2002).

Evidence1033
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10419465
xref: http://identifiers.org/pubmed/17651088
xref: http://identifiers.org/pubmed/11706043
xref: http://identifiers.org/pubmed/17556371
comment: At the late endosome membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger (Sbrissa et al. 2002, Cao et al. 2007). The PIKFYVE kinase component phosphorylates phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,5-bisphosphate PI(3,5)P2 (Sbrissa et al. 1999). The PAS complex is present in the cytosol and is recruited to the membrane (Sbrissa et al. 2007).

Evidence1034
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18950639
xref: http://identifiers.org/pubmed/17556371
comment: At the late endosome membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger. The FIG4 phosphatase component dephosphorylates phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) (Sbrissa et al. 2007, Sbrissa et al. 2008).

http://identifiers.org/pubmed/9923613
type: PublicationXref
id: 9923613
author: Caffrey, JJ
author: Hidaka, K
author: Hirata, M
author: Shears, Stephen B
author: Matsuda, M
db: Pubmed
title: The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification
source: FEBS Lett 442:99-104
year: 1999

Evidence1035
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14722070
xref: http://identifiers.org/pubmed/14660569
xref: http://identifiers.org/pubmed/12890864
xref: http://identifiers.org/pubmed/18524850
xref: http://identifiers.org/pubmed/17651088
xref: http://identifiers.org/pubmed/16787938
comment: At the late endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2), myotubularin-related protein 4 (MTMR4), and myotubularin-related protein 7 (MTMR7) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P). The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008, Tsujita et al. 2004, Tronchere et al. 2004), MTMR2 (Cao et al. 2008), MTMR4 (Lorenzo et al. 2006), and MTMR7 (Mochizuki & Majerus 2003, Lorenzo et al. 2006).

Evidence1036
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10419465
xref: http://identifiers.org/pubmed/12270933
comment: At the late endosome membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger. The PIKFYVE kinase component phosphorylates phosphatidylinositol (PI) to phosphatidylinositol 5-phosphate (PI5P) (Sbrissa et al. 1999, Sbrissa et al. 2002). The PAS complex is present in the cytosol and is recruited to the membrane.

http://identifiers.org/pubmed/2069720
type: PublicationXref
id: 2069720
author: Myöhänen, S
author: Kauppinen, L
author: Jänne, J
author: Wahlfors, J
author: Alhonen, L
db: Pubmed
title: Human spermidine synthase gene: structure and chromosomal localization
source: DNA Cell Biol 10:467-74
year: 1991

Evidence1037
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7628435
xref: http://identifiers.org/pubmed/17651088
xref: http://identifiers.org/pubmed/8999962
xref: http://identifiers.org/pubmed/10766823
xref: http://identifiers.org/pubmed/10805725
comment: At the late endosome membrane, phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) aka VPS34 binds to phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4). The PIK3C3:PIK3R4 complex and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 3-phosphate (PI3P). The following lists the above proteins with their corresponding literature references: PIK3C3:PIK3R4 (Panaretou et al. 1997, Volinia et al. 1995, Cao et al. 2007) and PIK3C2A (Arcaro et al. 2000, Domin et al. 2000).

Evidence1038
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14722070
xref: http://identifiers.org/pubmed/14660569
xref: http://identifiers.org/pubmed/12890864
xref: http://identifiers.org/pubmed/11733541
xref: http://identifiers.org/pubmed/18524850
xref: http://identifiers.org/pubmed/17651088
xref: http://identifiers.org/pubmed/16787938
comment: At the late endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2), myotubularin-related protein 4 (MTMR4), and myotubularin-related protein 7 (MTMR7) dephosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol (PI). The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008, Tsujita et al. 2004, Tronchere et al. 2004, Kim et al. 2002); MTMR2 (Cao et al. 2008, Kim et al. 2002); MTMR4 (Lorenzo et al. 2006); and MTMR7 (Mochizuki & Majerus 2003, Lorenzo et al. 2006).

Evidence1039
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11733541
xref: http://identifiers.org/pubmed/18950639
xref: http://identifiers.org/pubmed/18524850
xref: http://identifiers.org/pubmed/17651088
xref: http://identifiers.org/pubmed/10805725
xref: http://identifiers.org/pubmed/17556371
comment: At the late endosome membrane, the primary event is the dephosphorylation of the phosphoinositide phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 5-phosphate (PI5P) (Sbrissa et al. 2007, Sbrissa et al. 2008, Cao et al. 2007, Cao et al. 2008, Arcaro et al. 2000, Kim et al. 2002).

UniProt:Q55GN3
type: ProteinReference
xref: UnificationXref12324
organism: Dictyostelium discoideum

UniProt:Q55GN6
type: ProteinReference
xref: UnificationXref7139
organism: Dictyostelium discoideum

Evidence1045
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11734571
xref: http://identifiers.org/pubmed/8656081
xref: http://identifiers.org/pubmed/9089413
comment: 3-hydroxy tetracosahexaenoyl-CoA undergoes dehydrogenation to form 1-(3-oxo-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA, catalysed by DBP. DBP is a bifunctional enzyme, involved in the hydration of a variety of trans-2,3-dehydroacyl-CoA's but also mediating dehydrogenation of a variety of 3-hydroxyacyl-CoA's (Jiang et al. 1997).

Evidence1046
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11734571
xref: http://identifiers.org/pubmed/8656081
comment: The final step in the beta-oxidation process is the thiolytic cleavage of 1-(3-oxo-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA to form docosahexaenoyl-CoA (DHA-CoA). This step is catalysed by both sterol carrier protein X (SCPx) and the classic 3-ketoacyl-CoA thiolase (this reaction) (Ferdinandusse et al. 2001).

Evidence1043
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12324224
xref: http://identifiers.org/pubmed/12897190
xref: http://identifiers.org/pubmed/8663162
xref: http://identifiers.org/pubmed/11500517
xref: http://identifiers.org/pubmed/8656081
comment: The 24-carbon tetracosahexaenoyl-CoA (6,9,12,15,18,21-24:6(n-3) is transported to peroxisomes to undergo a putative single cycle of peroxisomal beta-oxidation, producing Docosahexaenoic Acid (DHA) (Sprecher 2002, Luthria et al. 1996).

Evidence1044
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11500517
xref: http://identifiers.org/pubmed/11734571
xref: http://identifiers.org/pubmed/8656081
xref: http://identifiers.org/pubmed/9089413
comment: Delta2-THA-CoA is hydrated to 3-hydroxyacyl-CoA intermediate 1-(3-hydroxy-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA by HSD17B4/DBP (d-bifunctional protein) dimer.

Evidence1041
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9242906
comment: Phospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such as choline. These molecules are a major constituent of cellular membranes, where their diverse structures and asymmetric distributions play major roles in determining membrane properties (Dowhan 1997). The four major classes of phospholipids in human plasma membranes are phosphatidylethanolamine, phosphatidylserine, phosphatidylcholine, and sphingomyelin. The first three are derivatives of glycerol while sphingomyelin is a derivative of serine. Here, pathways for the metabolism of glycerophospholipids, phosphphatidylinositol (PI), and sphingolipids are annotated.

Kinesins
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction400
pathway component: BiochemicalReaction398
pathway component: BiochemicalReaction396
pathway component: BiochemicalReaction395
pathway component: BiochemicalReaction399
pathway component: BiochemicalReaction394
pathway component: BiochemicalReaction397
evidence: Evidence696
xref: UnificationXref5144
xref: RelationshipXref369
xref: UnificationXref5145
pathway order: PathwayStep679
pathway order: PathwayStep678
pathway order: PathwayStep674
pathway order: PathwayStep677
pathway order: PathwayStep676
pathway order: PathwayStep675
pathway order: PathwayStep673
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

Evidence1042
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref1917
xref: http://identifiers.org/pubmed/7061494
comment: In the first step the precursor apha-linolenic (9,12,15-18:3(n-3)) acid is activated to a high energy form known as alpha-linolenoyl-CoA (9Z,12Z,15Z-octadecatrienoyl-CoA) by the iron enzyme long-chain-fatty-acid-CoA-ligase (acyl-CoA synthetase 1, ACSL1) and coenzyme A.

Evidence1040
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20192774
xref: http://identifiers.org/pubmed/19196647
xref: http://identifiers.org/pubmed/18216768
xref: http://identifiers.org/pubmed/16828287
xref: http://identifiers.org/pubmed/17330069
xref: http://identifiers.org/pubmed/15269334
xref: http://identifiers.org/pubmed/18216767
xref: http://identifiers.org/pubmed/20043944
xref: http://identifiers.org/pubmed/20559318
xref: http://identifiers.org/pubmed/17035995
xref: http://identifiers.org/pubmed/20861159
xref: http://identifiers.org/pubmed/18784754
xref: http://identifiers.org/pubmed/18726176
xref: http://identifiers.org/pubmed/17605038
xref: http://identifiers.org/pubmed/15170460
comment: Phosphatidylinositol (PI), a membrane phospholipid, can be reversibly phosphorylated at the 3, 4, and 5 positions of the inositol ring to generate seven phosphoinositides: phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P), phosphatidylinositol 5-phosphate (PI5P), phosphatidylinositol 3,4-bisphosphate PI(3,4)P2, phosphatidylinositol 4,5-bisphosphate PI(4,5)P2, phosphatidylinositol 3,5-bisphosphate PI(3,5)P2, and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3). These seven phosphoinositides, which are heterogeneously distributed within cells, can serve as signature components of different intracellular compartment membranes and so help to mediate specificity of membrane interactions. Phosphoinositide levels are tightly regulated spatially and temporally by the action of various kinases and phosphatases whilst PI(4,5)P2 is also a substrate for phospholipase C. The differential localisation of each of these enzymes on specific compartment membranes ensures maintenance of the heterogeneous distribution of phosphoinositides despite the continuous membrane flow from one compartment to another. PI is primarily synthesised in the endoplasmic reticulum from where the phospholipid is exported to other compartments via membrane traffic or via cytosolic phospholipid transfer proteins. Phosphorylation of PI to PI4P primarily occurs in the Golgi, where PI4P plays an important role in the biogenesis of transport vesicles such as the secretory vesicle involved in its transport to the plasma membrane. At this place, PI4P has a major function acting as a precursor of PI(4,5)P2, which is located predominantly at this membrane. PI(4,5)P2 binds and regulates a wide range of proteins that function on the cell surface and serves as a precursor for second messengers. Additionally, it helps define this membrane as a target for secretory vesicles, functions as a coreceptor in endocytic processes, and functions as a cofactor for actin nucleation. At the pl…

Evidence1049
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12897190
xref: http://identifiers.org/pubmed/9684854
xref: http://identifiers.org/pubmed/11500517
comment: Prior to this reaction all the enzymes involved in the desaturation and elongation of linoleic acid are located in the ER, but for this last step tetracosapentaenoyl-CoA must be transferred to the peroxisomes for partial beta-oxidation to docosapentaenoyl-CoA (DPA-CoA, 4,7,10,13,16-22:5(n-6)) (Su et al. 2001).

Evidence1047
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8443237
xref: http://identifiers.org/pubmed/16828546
comment: Alpha-linolenic acid (ALA, 18:3(n-3)) is an omega-3 fatty acid, supplied through diet as it cannot be synthesized by humans. ALA has an important role in human health. It is converted to long chain more unsaturated n-3 fatty acids by a series of alternating desaturation and elongation reactions. Omega-3 products of ALA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reduce inflammation and may help lower risk of chronic diseases, such as heart disease and arthritis. All the desaturation and elongation steps occur in the endoplasmic reticulum (ER) except for the final step which requires translocation to peroxisomes for partial beta-oxidation. The alpha-linolenic acid pathway involves the following steps: 18:3(n-3)--> 18:4(n-3)-->20:4(n-3)-->20:5(n-3)-->22:5(n-3)-->24:5(n-3)-->24:6(n-3)-->22:6(n-3). Two desaturation enzymes are involved in this process: delta-6 desaturase that converts 18:3(n-3) to 18:4(n-3) and 24:5(n-3) to 24:6(n-3) respectively, delta-5 desaturase 20:4(n-3) to 20:5(n-3). (Sprecher 2002).

Evidence1048
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref1917
xref: http://identifiers.org/pubmed/20480548
xref: http://identifiers.org/pubmed/7061494
xref: http://identifiers.org/pubmed/18024425
comment: The dietary essential fatty acid (EFA) linoleic acid (LA) is activated to a high energy form known as linoleoyl-CoA by the action of long-chain acyl-CoA synthetases (ACSLs). Thioesterification of long-chain fatty acids into their acyl-CoA derivatives is considered to be the first committed step in fatty acid metabolism. Formation of acyl-CoA allows an otherwise non-reactive fatty acid to participate in biosynthetic or catabolic pathways. This acyl CoA form is converted to its longer-chain polyunsaturated products by a series of desaturation and elongation reactions (Ellis et al. 2010, Watkins 2008).

http://identifiers.org/pubmed/11470804
type: PublicationXref
id: 11470804
author: Yamamoto, TT
author: Kamataki, A
author: Magoori, K
author: Takei, YA
author: Sakai, J
author: Sone, H
author: Fujino, T
author: Ioka, RX
author: Takahashi, S
db: Pubmed
title: Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product
source: J Biol Chem 276:35961-6
year: 2001

Evidence1054
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11672424
xref: http://identifiers.org/pubmed/12627223
comment: Prostaglandin D2 (PGD2) is a structural isomer of prostaglandin E2 (PGE2). There is a 9-keto and 11-hydroxy group on PGE2 with these substituents reversed on PGD2. PGD2 is formed by two evolutionarily distinct, but functionally convergent, prostaglandin D synthases: lipocalin-type prostaglandin-D synthase aka Prostaglandin-H2 D-isomerase (PTDGS) and hematopoietic prostaglandin D synthase (HPGDS). One of the main differences between these two proteins is that HPGDS requires glutathione (GSH) for catalysis while PTDGS can function without this cofactor. Here, HPGDS with GSH promotes the isomerisation of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2) (Jowsey et al. 2001, Inoue et al. 2003).

Evidence1055
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3862115
xref: http://identifiers.org/pubmed/15047184
comment: Aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS is the enzyme involved in NADPH-dependent prostaglandin D2 11-keto reductase activity of reducing prostaglandin D2 (PGD2) to 11-epi-Prostaglandin F2alpha (11-epi-PGF2a) (Liston & Roberts 1985, Koda et al. 2004).

Evidence1056
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8576264
xref: http://identifiers.org/pubmed/17449869
comment: Prostaglandin reductase 1 (PTGR1) aka LTB4DH is a 13-prostaglandin reductase which metabolises eicosanoids by catalysing NADH/NADPH-dependant double bond reduction in 15-keto-prostaglandin E2 (15k-PGE2) and F2alpha (15k-PGF2a) to produce 13,14-dihydro-15-keto-prostaglandin E2 (dhk-PGE2) and F2alpha (dhk-PGF2a) respectively (Yokomizo 1996). This has been inferred from the reaction event in mice involving prostaglandin reductase 2 (Ptgr2) (Chou et al. 2007).

Evidence1057
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref1943
xref: http://identifiers.org/pubmed/20655950
xref: http://identifiers.org/pubmed/19244215
comment: The bioactive prostaglandin (PG) signalling molecules, including PGA2, PGE2, PGF2a, and PGI2 (prostacyclin) are synthesised from arachidonic acid and its products by various prostaglandin synthase type enzymes. Prostaglandin H2 (PGH2) is the starting point for the synthesis of Thromboxanes (TXs) (Buczynski et al. 2009, Vance & Vance 2008). PGs and TXs are collectively known as the prostanoids. Two enzymes, PTGS1 and 2 (COX1 and 2) both catalyze the two-step conversion of arachidonic acid to PGH2. PTGS1 is constitutively expressed in many cell types while PTGS2 is induced in response to stress and mediates the syntheses of prostaglandins associated with pain, fever, and inflammation. Aspirin irreversibly inactivates both enzymes (though it acts more efficiently on PTGS1), explaining both its antiinflammatory effects and side effects like perturbed gastic acid secretion. Drugs like celecoxib, by specifically inhibiting PTGS2, have a strong anti-inflammatory effect with fewer side effects. These PTGS2-specific drugs, however, probably because of their effects on the balance of prostaglandin synthesis in platelets and endothelial cells, can also promote blood clot formation (Buczynski et al. 2009; Stables & Gilroy 2011).

Evidence1050
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12324224
xref: http://identifiers.org/pubmed/8609415
xref: http://identifiers.org/pubmed/17168669
xref: http://identifiers.org/pubmed/14636670
xref: http://identifiers.org/pubmed/10903473
comment: Linoleic acid (LA, 18:2(n-6)) is an omega-6 fatty acid obtained through diet, mainly from vegetable oils. Omega-6 fatty acids helps stimulate skin and hair growth, maintain bone health, regulate metabolism, and maintain the reproductive system. All the desaturation and elongation steps occur in the endoplasmic reticulum (ER) except for the final step which requires translocation to peroxisomes for partial beta-oxidation. The linoleic acid pathway involves the following steps: 18:2(n-6)-->18:3(n-6)--> 20:3(n-6)-->20:4(n-6)-->22:4(n-6)-->24:4(n-6)-->24:5(n-6)-->22:5(n-6). Two desaturation enzymes are involved in this process: delta-6 desaturase which converts 18:2(n-6) to 18:3 (n-6) and 24:4(n-6) to 24:5(n-6) respectively, and delta-5 desaturase which converts 20:3(n-6) to 20:4(n-6). (Sprecher 2002).

Evidence1051
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12324224
xref: http://identifiers.org/pubmed/10903473
xref: http://identifiers.org/pubmed/16828546
comment: There are two major classes of polyunsaturated fatty acids (PUFAs): the omega-3 (n-3) and the omega-6 (n-6) fatty acids, where the number corresponds to the position of the first double bond proximate to the methyl end of the fatty acid. Omega-3 and omega-6 fatty acids are considered essential fatty acids. Humans cannot synthesize them, instead they are supplied through diet. Linoleic acid (LA, 18:2(n-6)), a major component of omega-6 fatty acids and alpha-linolenic acid (ALA, 18:2(n-3)) a major component of omega-3 fatty acids are the two main dietary essential fatty acids (EFAs) in humans. ALA and LA obtained from diet are converted in the body into their longer chain and more unsaturated omega-3 and omega-6 products by a series of desaturation and elongation steps. Metabolism of ALA and LA to their corresponding products is mediated via common enzyme systems. In humans ALA is finally converted to docosahexaenoic acid (DHA, C22:6(n-3)), and LA is converted to docosapentaenoic acid (DPA, C22:5(n-6)). The intermediary omega-3 and omega-6 series fatty acids play a significant role in health and disease by generating potent modulatory molecules for inflammatory responses, including eicosanoids (prostaglandins, and leukotrienes), and cytokines (interleukins) and affecting the gene expression of various bioactive molecules (Kapoor & Huang 2006, Sprecher 2002, Burdge 2006).

Evidence1052
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16475787
xref: http://identifiers.org/pubmed/10622721
xref: http://identifiers.org/pubmed/14979715
comment: Aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS is responsible for the reduction of prostaglandin H2 (PGH2) to prostaglandin F2alpha (PGF2a) (Suzuki-Yamamoto et al. 1999, Komoto et al. 2004, Komoto et al. 2006). There is an additional way of achieving this reaction involving the prostamide/prostaglandin F synthase, FAM213B and thioredoxin (TRX).

Evidence1053
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10922363
comment: Prostaglandin E2 (PGE2) is the most abundant prostanoid in the body and is a major mediator of inflammation in diseases such as osteoarthritis and rheumatoid arthritis. The product of arachidonic acid, prostaglandin H2 (PGH2) serves as the substrate for the isomerization to PGE2. The conversion is carried out by prostaglandin E synthase (PGES), of which there are three forms. Two are membrane-bound enzymes and are designated as mPGES-1 (functionally linked with COX-2) and mPGES-2 (golgi membrane-associated, functionally coupled with both COX-1 and COX-2). The other is cytosolic (cPGES, PTGES3) and functionally linked to COX-1 to produce PGE2 immediately. In this reaction, cPGES is used for conversion of PGH2 to PGE2.

Evidence1058
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2995393
xref: http://identifiers.org/pubmed/6490615
comment: Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that catalyzes the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) to the dihydroxy acid leukotriene B4 (LTB4) (Radmark et al. 1984, McGee & Fitzpatrick 1985).

Evidence1059
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9461497
xref: http://identifiers.org/pubmed/8394361
xref: http://identifiers.org/pubmed/8576264
comment: Prostaglandin reductase 1 (PTGR1) aka LTB4DH metabolizes eicosanoids by catalysing the oxidation of leukotriene B4 (LTB4) to form 12-oxo-Leukotriene B4 (12-oxoLTB4) aka 12-Keto-LTB4. The gene was originally cloned as leukotriene B4 12-hydroxydehydrogenase (LTB4DH) but was later discovered to have dual functionality as a prostaglandin reductase (Yokomizo et al. 1996). This reaction has been inferred from a reaction in pigs (Yokomizo et al. 1993, Ensor et al. 1998).

UniProt:Q55GP8
type: ProteinReference
xref: UnificationXref11099
organism: Dictyostelium discoideum

UnificationXref6606
type: UnificationXref
id: REACT_10957
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10957.1

UnificationXref6605
type: UnificationXref
id: 192087
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192087

UnificationXref6604
type: UnificationXref
id: CHEBI:16496
db: ChEBI

UnificationXref6603
type: UnificationXref
id: REACT_94804
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94804.9

UnificationXref6602
type: UnificationXref
id: 3644491
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644491

UnificationXref6601
type: UnificationXref
id: REACT_10258
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10258.1

UnificationXref6600
type: UnificationXref
id: 191980
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191980

Evidence1060
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2753893
xref: http://identifiers.org/pubmed/10064732
comment: On formation, leukotriene C4 (LTC4) is exported to the extracellular region by the ABCC1 transporter (Sjolinder et al. 1999, Lam et al. 1989) and processed further by cleavage reactions.

UnificationXref6609
type: UnificationXref
id: 3644494
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644494

UnificationXref6608
type: UnificationXref
id: 3644493
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644493

UnificationXref6607
type: UnificationXref
id: 3644492
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644492

UnificationXref2414
type: UnificationXref
id: 3644519
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644519

UnificationXref2415
type: UnificationXref
id: Q554S4
db: UniProt

UnificationXref2412
type: UnificationXref
id: 3644518
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644518

UnificationXref2413
type: UnificationXref
id: Q54SV9
db: UniProt

UnificationXref2410
type: UnificationXref
id: 3644517
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644517

UnificationXref2411
type: UnificationXref
id: Q556M5
db: UniProt

UnificationXref6698
type: UnificationXref
id: 3644551
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644551

UnificationXref6699
type: UnificationXref
id: REACT_108344
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108344.9

pol II open pre-initiation complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2456
component stoichiometry: Stoichiometry2461
component stoichiometry: Stoichiometry2454
component stoichiometry: Stoichiometry2455
component stoichiometry: Stoichiometry2462
component stoichiometry: Stoichiometry2460
component stoichiometry: Stoichiometry2465
component: Protein2682
component: TFIIA (name copied from entity in Homo sapiens)
component: TFIID (name copied from entity in Homo sapiens)
component: TFIIE (name copied from entity in Homo sapiens)
component: TFIIH (name copied from entity in Homo sapiens)
component: RNA Polymerase II (unphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: PhysicalEntity291
xref: UnificationXref11807
cellular location: GO:0005654
comment: Reactome DB_ID: 3642397

UnificationXref2418
type: UnificationXref
id: 3644521
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644521

Aborted elongation complex after arrest (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2435
component stoichiometry: Stoichiometry2434
component stoichiometry: Stoichiometry2437
component stoichiometry: Stoichiometry2438
component stoichiometry: Stoichiometry2433
component stoichiometry: Stoichiometry2432
component stoichiometry: Stoichiometry2436
component stoichiometry: Stoichiometry2442
component stoichiometry: Stoichiometry2441
component stoichiometry: Stoichiometry2439
component stoichiometry: Stoichiometry2440
component: DSIF complex (name copied from entity in Homo sapiens)
component: TFIIF (name copied from entity in Homo sapiens)
component: Protein2671
component: FACT complex (name copied from entity in Homo sapiens)
component: Elongin Complex (name copied from entity in Homo sapiens)
component: P-TEFb complex (name copied from entity in Homo sapiens)
component: PhysicalEntity283
component: PhysicalEntity284
component: NELF complex (name copied from entity in Homo sapiens)
component: Complex308
component: Protein1129
xref: UnificationXref11771
cellular location: GO:0005654
comment: Reactome DB_ID: 3643245

UnificationXref2419
type: UnificationXref
id: Q54CS3
db: UniProt

UnificationXref2416
type: UnificationXref
id: 3644520
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644520

UnificationXref2417
type: UnificationXref
id: Q54QD2
db: UniProt

pol II promoter:TFIID:TFIIA:TFIIB complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2471
component stoichiometry: Stoichiometry2467
component stoichiometry: Stoichiometry2470
component: Protein2682
component: TFIIA (name copied from entity in Homo sapiens)
component: pol II promoter:TFIID complex (name copied from entity in Homo sapiens)
xref: UnificationXref11811
cellular location: GO:0005654
comment: Reactome DB_ID: 3642330

UnificationXref6693
type: UnificationXref
id: 3644548
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644548

pol II promoter:TFIID complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2469
component stoichiometry: Stoichiometry2468
component: TFIID (name copied from entity in Homo sapiens)
component: PhysicalEntity293
xref: UnificationXref11810
cellular location: GO:0005654
comment: Reactome DB_ID: 3642329

UnificationXref6692
type: UnificationXref
id: REACT_10938
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10938.1

pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2476
component stoichiometry: Stoichiometry2477
component: pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex (name copied from entity in Homo sapiens)
component: TFIIE (name copied from entity in Homo sapiens)
xref: UnificationXref11818
cellular location: GO:0005654
comment: Reactome DB_ID: 3642762

UnificationXref6691
type: UnificationXref
id: 193843
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193843

Pol II initiation complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2484
component stoichiometry: Stoichiometry2487
component stoichiometry: Stoichiometry2486
component stoichiometry: Stoichiometry2480
component stoichiometry: Stoichiometry2479
component stoichiometry: Stoichiometry2485
component: Protein2682
component: TFIIA (name copied from entity in Homo sapiens)
component: TFIID (name copied from entity in Homo sapiens)
component: TFIIE (name copied from entity in Homo sapiens)
component: PhysicalEntity294
component: RNA Polymearse II:NTP:TFIIF complex (name copied from entity in Homo sapiens)
xref: UnificationXref11828
cellular location: GO:0005654
comment: Reactome DB_ID: 3642399

UnificationXref6690
type: UnificationXref
id: REACT_118457
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118457.7

TFIIA (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2458
component stoichiometry: Stoichiometry2459
component stoichiometry: Stoichiometry2457
component: Protein2679
component: Protein2680
component: Protein2681
xref: UnificationXref11800
cellular location: GO:0005654
comment: Reactome DB_ID: 3642096

UnificationXref6697
type: UnificationXref
id: REACT_10427
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10427.1

TFIIE (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2463
component stoichiometry: Stoichiometry2464
component: PhysicalEntity292
component: Protein2683
xref: UnificationXref11806
cellular location: GO:0005654
comment: Reactome DB_ID: 3642141

UnificationXref6696
type: UnificationXref
id: 193842
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193842

pol II closed pre-initiation complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2474
component stoichiometry: Stoichiometry2473
component stoichiometry: Stoichiometry2475
component: pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex (name copied from entity in Homo sapiens)
component: TFIIE (name copied from entity in Homo sapiens)
component: TFIIH (name copied from entity in Homo sapiens)
xref: UnificationXref11813
cellular location: GO:0005654
comment: Reactome DB_ID: 3642401

UnificationXref6695
type: UnificationXref
id: CHEBI:28540
db: ChEBI

Processing of Intronless Pre-mRNAs
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction144
pathway component: BiochemicalReaction143
evidence: Evidence261
xref: UnificationXref2351
xref: UnificationXref2350
pathway order: PathwayStep251
pathway order: PathwayStep252
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2472
component stoichiometry: Stoichiometry2466
component: RNA Polymerase II (unphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: pol II promoter:TFIID:TFIIA:TFIIB complex (name copied from entity in Homo sapiens)
xref: UnificationXref11812
cellular location: GO:0005654
comment: Reactome DB_ID: 3642331

UnificationXref6694
type: UnificationXref
id: REACT_87073
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87073.9

http://identifiers.org/pubmed/15611369
type: PublicationXref
id: 15611369
author: O'Donnell, CJ
author: Grant, SW
author: Cupples, LA
author: Waterman, MR
author: Brown, NJ
author: Demissie, S
author: Wang, Y
author: Womble, KE
author: Capdevila, JH
author: Gainer, JV
author: Bellamine, A
author: Dawson, EP
author: Guo, CY
db: Pubmed
title: Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension
source: Circulation 111:63-9
year: 2005

TFIID (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2451
component stoichiometry: Stoichiometry2446
component stoichiometry: Stoichiometry2444
component stoichiometry: Stoichiometry2450
component stoichiometry: Stoichiometry2453
component stoichiometry: Stoichiometry2447
component stoichiometry: Stoichiometry2449
component stoichiometry: Stoichiometry2452
component stoichiometry: Stoichiometry2445
component stoichiometry: Stoichiometry2443
component stoichiometry: Stoichiometry2448
component: PhysicalEntity290
component: Protein2675
component: Protein2677
component: PhysicalEntity289
component: Protein2674
component: Protein2673
component: PhysicalEntity287
component: Protein2678
component: PhysicalEntity288
component: Protein2676
component: Protein2672
xref: UnificationXref11792
cellular location: GO:0005654
comment: Reactome DB_ID: 3642133

http://identifiers.org/pubmed/22798961
type: PublicationXref
id: 22798961
author: Wang, Xiaohong
author: Li, Ju-Pi
author: Chuang, Huai-Chia
author: Tan, Tse-Hua
db: Pubmed
title: Regulation of PKC-? function by phosphorylation in T cell receptor signaling
source: Front Immunol 3:197
year: 2012

UnificationXref2423
type: UnificationXref
id: Q54DT2
db: UniProt

UnificationXref2424
type: UnificationXref
id: 3644524
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644524

UnificationXref2425
type: UnificationXref
id: Q1ZXL7
db: UniProt

UnificationXref2426
type: UnificationXref
id: 3644525
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644525

UnificationXref2420
type: UnificationXref
id: 3644522
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644522

UnificationXref2421
type: UnificationXref
id: Q1ZXF3
db: UniProt

UnificationXref2422
type: UnificationXref
id: 3644523
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644523

http://identifiers.org/pubmed/19416660
type: PublicationXref
id: 19416660
author: Ren, M
author: Xu, Y
author: Malhotra, A
author: Schlame, M
db: Pubmed
title: Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species
source: Biochim Biophys Acta 1791:314-20
year: 2009

UnificationXref2427
type: UnificationXref
id: Q1ZXF5
db: UniProt

UnificationXref2428
type: UnificationXref
id: 3644526
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644526

UnificationXref2429
type: UnificationXref
id: Q54SK0
db: UniProt

RNA Pol II (hypophosphorylated):capped pre-mRNA complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2415
component stoichiometry: Stoichiometry2414
component stoichiometry: Stoichiometry2413
component stoichiometry: Stoichiometry2429
component: Protein2671
component: RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: PhysicalEntity76
component: Cap Binding Complex (CBC) (name copied from entity in Homo sapiens)
xref: UnificationXref11766
cellular location: GO:0005654
comment: Reactome DB_ID: 3643212

RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2417
component stoichiometry: Stoichiometry2425
component stoichiometry: Stoichiometry2427
component stoichiometry: Stoichiometry2422
component stoichiometry: Stoichiometry2420
component stoichiometry: Stoichiometry2421
component stoichiometry: Stoichiometry2416
component stoichiometry: Stoichiometry2424
component stoichiometry: Stoichiometry2418
component stoichiometry: Stoichiometry2428
component stoichiometry: Stoichiometry2419
component stoichiometry: Stoichiometry2423
component stoichiometry: Stoichiometry2426
component: Protein647
component: Protein636
component: Protein645
component: Protein637
component: Protein646
component: TFIIF (name copied from entity in Homo sapiens)
component: Protein639
component: Protein644
component: Protein643
component: Protein642
component: Protein638
component: Protein641
component: Protein640
xref: UnificationXref11765
cellular location: GO:0005654
comment: Reactome DB_ID: 3643211

DSIF:NELF:early elongation complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2431
component stoichiometry: Stoichiometry2411
component: RNA Pol II (hypophosphorylated) complex bound to DSIF protein (name copied from entity in Homo sapiens)
component: NELF complex (name copied from entity in Homo sapiens)
xref: UnificationXref11768
cellular location: GO:0005654
comment: Reactome DB_ID: 3643214

RNA Pol II (hypophosphorylated) complex bound to DSIF protein (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2430
component stoichiometry: Stoichiometry2412
component: RNA Pol II (hypophosphorylated):capped pre-mRNA complex (name copied from entity in Homo sapiens)
component: DSIF complex (name copied from entity in Homo sapiens)
xref: UnificationXref11767
cellular location: GO:0005654
comment: Reactome DB_ID: 3643213

RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2396
component stoichiometry: Stoichiometry2397
component: TFIIF (name copied from entity in Homo sapiens)
component: Complex308
xref: UnificationXref11754
cellular location: GO:0005654
comment: Reactome DB_ID: 3643174

Processive elongation complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2409
component stoichiometry: Stoichiometry2403
component stoichiometry: Stoichiometry2407
component stoichiometry: Stoichiometry2405
component stoichiometry: Stoichiometry2408
component stoichiometry: Stoichiometry2402
component stoichiometry: Stoichiometry2401
component stoichiometry: Stoichiometry2410
component stoichiometry: Stoichiometry2406
component stoichiometry: Stoichiometry2404
component stoichiometry: Stoichiometry2400
component: DSIF complex (name copied from entity in Homo sapiens)
component: Protein2671
component: FACT complex (name copied from entity in Homo sapiens)
component: Elongin Complex (name copied from entity in Homo sapiens)
component: SmallMolecule345
component: P-TEFb complex (name copied from entity in Homo sapiens)
component: PhysicalEntity283
component: PhysicalEntity284
component: NELF complex (name copied from entity in Homo sapiens)
component: RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: Protein1129
xref: UnificationXref11758
cellular location: GO:0005654
comment: Reactome DB_ID: 3643241

Elongin B:C complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2382
component stoichiometry: Stoichiometry2381
component: PhysicalEntity282
component: Protein2668
xref: UnificationXref11742
cellular location: GO:0005654
comment: Reactome DB_ID: 3643237

NELF complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2390
component stoichiometry: Stoichiometry2393
component stoichiometry: Stoichiometry2391
component stoichiometry: Stoichiometry2392
component: Protein2670
component: PhysicalEntity285
component: PhysicalEntity286
component: Protein2669
xref: UnificationXref11753
cellular location: GO:0005654
comment: Reactome DB_ID: 3643200

UnificationXref2432
type: UnificationXref
id: 3644528
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644528

UnificationXref2433
type: UnificationXref
id: Q54ZM4
db: UniProt

UnificationXref2430
type: UnificationXref
id: 3644527
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644527

UnificationXref2431
type: UnificationXref
id: Q54Q53
db: UniProt

UnificationXref2436
type: UnificationXref
id: 3644530
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644530

UnificationXref2437
type: UnificationXref
id: Q54D38
db: UniProt

UnificationXref2434
type: UnificationXref
id: 3644529
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644529

UnificationXref2435
type: UnificationXref
id: Q54LT7
db: UniProt

UnificationXref2438
type: UnificationXref
id: 3644531
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644531

UnificationXref2439
type: UnificationXref
id: Q556M4
db: UniProt

http://identifiers.org/pubmed/19487573
type: PublicationXref
id: 19487573
author: Agami, Reuven
author: Rouhanifard, Sara H
author: Holland, Eric C
author: Tuschl, Thomas
author: Huse, Jason T
author: Hambardzumyan, Dolores
author: Brennan, Cameron
author: Sohn-Lee, Cherin
author: le Sage, Carlos
author: Wee, Boyoung
author: Pena, John
db: Pubmed
title: The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
source: Genes Dev. 23:1327-37
year: 2009

Active RNA Polymerase I (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2569
component stoichiometry: Stoichiometry2570
component: RNA Polymerase I Holoenzyme (name copied from entity in Homo sapiens)
component: Protein2688
xref: UnificationXref11916
cellular location: GO:0005654
comment: Reactome DB_ID: 3641928

http://identifiers.org/pubmed/14660560
type: PublicationXref
id: 14660560
author: Yu, Y
author: Arnold, E
author: Shen, N
author: Ding, Jianping
author: Xu, X
author: Jin, Y
author: Xu, F
author: Jia, J
author: Liu, Y
db: Pubmed
title: Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity
source: J Biol Chem 279:8378-88
year: 2004

RNA Polymerase III:TFIIIB:TFIIIC:Type 2 Open Promoter Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2602
component stoichiometry: Stoichiometry2592
component stoichiometry: Stoichiometry2598
component stoichiometry: Stoichiometry2571
component: TFIIIB-Type 1 and 2 Promoter Selective Complex (name copied from entity in Homo sapiens)
component: PhysicalEntity305
component: RNA Polymerase III Holoenzyme (name copied from entity in Homo sapiens)
component: TFIIIC (name copied from entity in Homo sapiens)
xref: UnificationXref11957
cellular location: GO:0005654
comment: Reactome DB_ID: 3643166

RNA Polymerase III Holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2584
component stoichiometry: Stoichiometry2585
component stoichiometry: Stoichiometry2574
component stoichiometry: Stoichiometry2577
component stoichiometry: Stoichiometry2575
component stoichiometry: Stoichiometry2576
component stoichiometry: Stoichiometry2582
component stoichiometry: Stoichiometry2581
component stoichiometry: Stoichiometry2583
component stoichiometry: Stoichiometry2590
component stoichiometry: Stoichiometry2591
component stoichiometry: Stoichiometry2586
component stoichiometry: Stoichiometry2578
component: Protein2690
component: Protein2684
component: Protein645
component: Protein637
component: HsRPC4:HsRPC5 (name copied from entity in Homo sapiens)
component: HsRPC8:HsRPC9 (name copied from entity in Homo sapiens)
component: Protein2685
component: HsRPC6:HsRPC3:HsRPC7 (name copied from entity in Homo sapiens)
component: Protein2693
component: Protein2691
component: Protein643
component: Protein642
component: Protein638
xref: UnificationXref11942
cellular location: GO:0005654
comment: Reactome DB_ID: 3643141

HsRPC8:HsRPC9 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2572
component stoichiometry: Stoichiometry2573
component: Protein2689
component: PhysicalEntity306
xref: UnificationXref11931
cellular location: GO:0005654
comment: Reactome DB_ID: 3643120

HsRPC4:HsRPC5 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2580
component stoichiometry: Stoichiometry2579
component: Protein2692
component: PhysicalEntity307
xref: UnificationXref11936
cellular location: GO:0005654
comment: Reactome DB_ID: 3643126

HsRPC6:HsRPC3:HsRPC7 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2589
component stoichiometry: Stoichiometry2587
component stoichiometry: Stoichiometry2588
component: Protein2695
component: Protein2694
component: PhysicalEntity308
xref: UnificationXref11941
cellular location: GO:0005654
comment: Reactome DB_ID: 3643136

TFIIIC (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2597
component stoichiometry: Stoichiometry2593
component stoichiometry: Stoichiometry2595
component stoichiometry: Stoichiometry2596
component stoichiometry: Stoichiometry2594
component: PhysicalEntity310
component: PhysicalEntity309
component: Protein2697
component: Protein2698
component: Protein2696
xref: UnificationXref11951
cellular location: GO:0005654
comment: Reactome DB_ID: 3643165

http://identifiers.org/pubmed/15381398
type: PublicationXref
id: 15381398
author: Jaffe, EK
db: Pubmed
title: The porphobilinogen synthase catalyzed reaction mechanism
source: Bioorg Chem 32:316-25
year: 2004

http://identifiers.org/pubmed/14660569
type: PublicationXref
id: 14660569
author: Chaussade, C
author: Mandel, JL
author: Liaubet, L
author: Payrastre, B
author: Pendaries, C
author: Tronchère, H
author: Laporte, J
author: Pirola, L
db: Pubmed
title: Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells
source: J Biol Chem 279:7304-12
year: 2004

Elongation complex prior to separation (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2549
component stoichiometry: Stoichiometry2542
component stoichiometry: Stoichiometry2547
component stoichiometry: Stoichiometry2551
component stoichiometry: Stoichiometry2546
component stoichiometry: Stoichiometry2544
component stoichiometry: Stoichiometry2550
component stoichiometry: Stoichiometry2543
component stoichiometry: Stoichiometry2548
component stoichiometry: Stoichiometry2545
component stoichiometry: Stoichiometry2541
component: DSIF complex (name copied from entity in Homo sapiens)
component: PhysicalEntity302
component: Protein2671
component: FACT complex (name copied from entity in Homo sapiens)
component: Elongin Complex (name copied from entity in Homo sapiens)
component: SmallMolecule345
component: P-TEFb complex (name copied from entity in Homo sapiens)
component: PhysicalEntity283
component: NELF complex (name copied from entity in Homo sapiens)
component: RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: Protein1129
xref: UnificationXref11893
cellular location: GO:0005654
comment: Reactome DB_ID: 3643247

Elongation complex with separated and uncleaved transcript (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2559
component stoichiometry: Stoichiometry2562
component stoichiometry: Stoichiometry2555
component stoichiometry: Stoichiometry2558
component stoichiometry: Stoichiometry2556
component stoichiometry: Stoichiometry2561
component stoichiometry: Stoichiometry2560
component stoichiometry: Stoichiometry2553
component stoichiometry: Stoichiometry2557
component stoichiometry: Stoichiometry2554
component stoichiometry: Stoichiometry2552
component: DSIF complex (name copied from entity in Homo sapiens)
component: Protein2671
component: FACT complex (name copied from entity in Homo sapiens)
component: Elongin Complex (name copied from entity in Homo sapiens)
component: SmallMolecule345
component: PhysicalEntity303
component: P-TEFb complex (name copied from entity in Homo sapiens)
component: PhysicalEntity283
component: NELF complex (name copied from entity in Homo sapiens)
component: RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: Protein1129
xref: UnificationXref11898
cellular location: GO:0005654
comment: Reactome DB_ID: 3643248

RNA Polymerase I Holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2567
component stoichiometry: Stoichiometry2564
component stoichiometry: Stoichiometry2563
component stoichiometry: Stoichiometry2566
component stoichiometry: Stoichiometry2568
component stoichiometry: Stoichiometry2565
component: Protein2684
component: Protein2687
component: Protein645
component: Protein2686
component: Protein2685
component: Protein638
xref: UnificationXref11911
cellular location: GO:0005654
comment: Reactome DB_ID: 3641927

http://identifiers.org/pubmed/7913615
type: PublicationXref
id: 7913615
author: Sheng, H
author: Warner, TD
author: Murad, F
author: Mitchell, JA
db: Pubmed
title: Effects of cyclic GMP on smooth muscle relaxation
source: Adv Pharmacol 26:171-94
year: 1994

UnificationXref2441
type: UnificationXref
id: Q1ZXG3
db: UniProt

UnificationXref2442
type: UnificationXref
id: 3644533
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644533

UnificationXref2443
type: UnificationXref
id: 3644534
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644534

UnificationXref2444
type: UnificationXref
id: 3644536
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644536

UnificationXref2445
type: UnificationXref
id: REACT_154243
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154243.3

UnificationXref2446
type: UnificationXref
id: CHEBI:17650
db: ChEBI

UnificationXref2447
type: UnificationXref
id: 193977
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193977

UnificationXref2448
type: UnificationXref
id: REACT_10255
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10255.2

UnificationXref2449
type: UnificationXref
id: CHEBI:16962
db: ChEBI

RNA Polymearse II:NTP:TFIIF complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2482
component stoichiometry: Stoichiometry2483
component stoichiometry: Stoichiometry2481
component: SmallMolecule345
component: TFIIH (name copied from entity in Homo sapiens)
component: RNA Polymerase II (unphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
xref: UnificationXref11827
cellular location: GO:0005654
comment: Reactome DB_ID: 3642398

pol II transcription complex containing 9 nucleotide long transcript (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2518
component stoichiometry: Stoichiometry2517
component stoichiometry: Stoichiometry2516
component: PhysicalEntity299
component: TFIIH (name copied from entity in Homo sapiens)
component: RNA Polymerase II (unphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
xref: UnificationXref11855
cellular location: GO:0005654
comment: Reactome DB_ID: 3642408

pol II transcription complex containing 11 nucleotide long transcript (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2519
component stoichiometry: Stoichiometry2521
component stoichiometry: Stoichiometry2520
component: PhysicalEntity300
component: TFIIH (name copied from entity in Homo sapiens)
component: RNA Polymerase II (unphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
xref: UnificationXref11858
cellular location: GO:0005654
comment: Reactome DB_ID: 3642650

pol II transcription complex containing 3 Nucleotide long transcript (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2506
component stoichiometry: Stoichiometry2503
component stoichiometry: Stoichiometry2508
component stoichiometry: Stoichiometry2504
component stoichiometry: Stoichiometry2502
component stoichiometry: Stoichiometry2507
component stoichiometry: Stoichiometry2505
component: Protein2682
component: TFIIA (name copied from entity in Homo sapiens)
component: TFIID (name copied from entity in Homo sapiens)
component: PhysicalEntity297
component: TFIIE (name copied from entity in Homo sapiens)
component: TFIIH (name copied from entity in Homo sapiens)
component: RNA Polymerase II (unphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
xref: UnificationXref11845
cellular location: GO:0005654
comment: Reactome DB_ID: 3642384

pol II transcription complex containing 4 nucleotide long transcript (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2509
component stoichiometry: Stoichiometry2511
component stoichiometry: Stoichiometry2513
component stoichiometry: Stoichiometry2514
component stoichiometry: Stoichiometry2510
component stoichiometry: Stoichiometry2512
component: TFIIA (name copied from entity in Homo sapiens)
component: TFIID (name copied from entity in Homo sapiens)
component: TFIIE (name copied from entity in Homo sapiens)
component: TFIIH (name copied from entity in Homo sapiens)
component: RNA Polymerase II (unphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: PhysicalEntity298
xref: UnificationXref11850
cellular location: GO:0005654
comment: Reactome DB_ID: 3642406

Early elongation complex with hyperphosphorylated Pol II CTD (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2534
component stoichiometry: Stoichiometry2530
component stoichiometry: Stoichiometry2529
component stoichiometry: Stoichiometry2531
component stoichiometry: Stoichiometry2533
component stoichiometry: Stoichiometry2532
component: PhysicalEntity301
component: DSIF complex (name copied from entity in Homo sapiens)
component: Protein2671
component: P-TEFb complex (name copied from entity in Homo sapiens)
component: NELF complex (name copied from entity in Homo sapiens)
component: RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
xref: UnificationXref11883
cellular location: GO:0005654
comment: Reactome DB_ID: 3643210

Elongation complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2536
component stoichiometry: Stoichiometry2535
component stoichiometry: Stoichiometry2537
component stoichiometry: Stoichiometry2538
component stoichiometry: Stoichiometry2540
component stoichiometry: Stoichiometry2539
component: Early elongation complex with hyperphosphorylated Pol II CTD (name copied from entity in Homo sapiens)
component: FACT complex (name copied from entity in Homo sapiens)
component: Elongin Complex (name copied from entity in Homo sapiens)
component: PhysicalEntity283
component: TFIIH (name copied from entity in Homo sapiens)
component: Protein1129
xref: UnificationXref11888
cellular location: GO:0005654
comment: Reactome DB_ID: 3643240

Pol II transcription complex containing extruded transcript to +30 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2525
component stoichiometry: Stoichiometry2523
component stoichiometry: Stoichiometry2524
component: PhysicalEntity69
component: TFIIH (name copied from entity in Homo sapiens)
component: RNA Polymerase II (unphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
xref: UnificationXref11861
cellular location: GO:0005654
comment: Reactome DB_ID: 3642667

Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2528
component stoichiometry: Stoichiometry2526
component stoichiometry: Stoichiometry2527
component: PhysicalEntity69
component: RNA polymerase II (phosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: TFIIH (name copied from entity in Homo sapiens)
xref: UnificationXref11870
cellular location: GO:0005654
comment: Reactome DB_ID: 3642668

Pol II Initiation complex with phosphodiester-PPi intermediate (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2494
component stoichiometry: Stoichiometry2491
component stoichiometry: Stoichiometry2490
component stoichiometry: Stoichiometry2489
component stoichiometry: Stoichiometry2493
component stoichiometry: Stoichiometry2492
component stoichiometry: Stoichiometry2488
component: Protein2682
component: TFIIA (name copied from entity in Homo sapiens)
component: TFIID (name copied from entity in Homo sapiens)
component: TFIIE (name copied from entity in Homo sapiens)
component: PhysicalEntity295
component: TFIIH (name copied from entity in Homo sapiens)
component: RNA Polymerase II (unphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
xref: UnificationXref11833
cellular location: GO:0005654
comment: Reactome DB_ID: 3642403

http://identifiers.org/pubmed/9763615
type: PublicationXref
id: 9763615
author: Roy, P
author: Sauter, B
author: Francisco, LM
author: Albert, ML
author: Silverstein, RL
author: Pearce, SF
author: Bhardwaj, N
db: Pubmed
title: Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
source: J Exp Med 188:1359-68
year: 1998

pol II transcription complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2497
component stoichiometry: Stoichiometry2495
component stoichiometry: Stoichiometry2500
component stoichiometry: Stoichiometry2496
component stoichiometry: Stoichiometry2498
component stoichiometry: Stoichiometry2501
component stoichiometry: Stoichiometry2499
component: Protein2682
component: TFIIA (name copied from entity in Homo sapiens)
component: TFIID (name copied from entity in Homo sapiens)
component: TFIIE (name copied from entity in Homo sapiens)
component: PhysicalEntity296
component: TFIIH (name copied from entity in Homo sapiens)
component: RNA Polymerase II (unphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
xref: UnificationXref11838
cellular location: GO:0005654
comment: Reactome DB_ID: 3642142

UnificationXref2440
type: UnificationXref
id: 3644532
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644532

UnificationXref6657
type: UnificationXref
id: REACT_10645
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10645.1

UnificationXref6656
type: UnificationXref
id: 193724
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193724

UnificationXref6655
type: UnificationXref
id: CHEBI:63838
db: ChEBI

UnificationXref6654
type: UnificationXref
id: REACT_32113
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32113.10

UnificationXref6659
type: UnificationXref
id: 193760
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193760

UnificationXref6658
type: UnificationXref
id: CHEBI:63829
db: ChEBI

(S)-Hydroxydecanoyl-CoA
type: SmallMoleculeReference
name: (S)-3-Hydroxydecanoyl-CoA
name: (S)-Hydroxydecanoyl-CoA [ChEBI:28325]
xref: UnificationXref6044

40S:eIF3:eIF1A (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2640
component stoichiometry: Stoichiometry2628
component stoichiometry: Stoichiometry2641
component: eIF3 subunits complex (name copied from entity in Homo sapiens)
component: PhysicalEntity320
component: 40S ribosomal complex (name copied from entity in Homo sapiens)
xref: UnificationXref12073
cellular location: GO:0005829
comment: Reactome DB_ID: 3641771

Ensembl:DDB0304892
type: ProteinReference
xref: UnificationXref8840
organism: Dictyostelium discoideum

UniProt:Q9BMX0
type: ProteinReference
xref: UnificationXref10615
organism: Dictyostelium discoideum

ternary complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2627
component stoichiometry: Stoichiometry2626
component: eIF2:GTP (name copied from entity in Homo sapiens)
component: PhysicalEntity319
xref: UnificationXref12046
cellular location: GO:0005829
comment: Reactome DB_ID: 3641510

Ensembl:DDB0304893
type: ProteinReference
xref: UnificationXref8842
organism: Dictyostelium discoideum

43S complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2642
component stoichiometry: Stoichiometry2645
component stoichiometry: Stoichiometry2644
component stoichiometry: Stoichiometry2643
component: eIF3 subunits complex (name copied from entity in Homo sapiens)
component: ternary complex (name copied from entity in Homo sapiens)
component: PhysicalEntity320
component: 40S ribosomal complex (name copied from entity in Homo sapiens)
xref: UnificationXref12074
cellular location: GO:0005829
comment: Reactome DB_ID: 3641511

Ensembl:DDB0304891
type: ProteinReference
xref: UnificationXref8844
organism: Dictyostelium discoideum

eIF3 subunits complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2629
component stoichiometry: Stoichiometry2632
component stoichiometry: Stoichiometry2635
component stoichiometry: Stoichiometry2631
component stoichiometry: Stoichiometry2630
component stoichiometry: Stoichiometry2636
component stoichiometry: Stoichiometry2634
component stoichiometry: Stoichiometry2639
component stoichiometry: Stoichiometry2637
component stoichiometry: Stoichiometry2638
component stoichiometry: Stoichiometry2633
component: PhysicalEntity321
component: Protein2711
component: Protein2710
component: Protein2709
component: Protein2705
component: Protein2706
component: Protein2708
component: Protein2712
component: Protein2714
component: Protein2713
component: Protein2707
xref: UnificationXref12072
cellular location: GO:0005829
comment: Reactome DB_ID: 3641494

eIF2:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2625
component stoichiometry: Stoichiometry2624
component: eIF2 subunit complex (name copied from entity in Homo sapiens)
component: SmallMolecule1
xref: UnificationXref12041
cellular location: GO:0005829
comment: Reactome DB_ID: 3641509

Ensembl:DDB0189571
type: ProteinReference
xref: UnificationXref8779
organism: Dictyostelium discoideum

Ensembl:DDB0204262
type: ProteinReference
xref: UnificationXref8813
organism: Dictyostelium discoideum

eIF5B:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2658
component stoichiometry: Stoichiometry2657
component: Protein2715
component: SmallMolecule1
xref: UnificationXref12100
cellular location: GO:0005829
comment: Reactome DB_ID: 3641765

http://identifiers.org/pubmed/9188692
type: PublicationXref
id: 9188692
author: Gill, GN
author: Kurten, RC
author: Cadena, DL
db: Pubmed
title: The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis
source: Biochemistry 36:6960-7
year: 1997

eIF4F (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2651
component stoichiometry: Stoichiometry2650
component stoichiometry: Stoichiometry2652
component: Protein2382
component: eIF4A subunits complex (name copied from entity in Homo sapiens)
component: PhysicalEntity252
xref: UnificationXref12087
cellular location: GO:0005829
comment: Reactome DB_ID: 3641521

UnificationXref6652
type: UnificationXref
id: REACT_10574
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10574.2

48S complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2654
component stoichiometry: Stoichiometry2655
component stoichiometry: Stoichiometry2653
component stoichiometry: Stoichiometry2647
component stoichiometry: Stoichiometry2646
component: PhysicalEntity322
component: PhysicalEntity325
component: PhysicalEntity326
component: eIF4F (name copied from entity in Homo sapiens)
component: 43S complex (name copied from entity in Homo sapiens)
xref: UnificationXref12090
cellular location: GO:0005829
comment: Reactome DB_ID: 3641524

UnificationXref6653
type: UnificationXref
id: 3644545
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644545

http://identifiers.org/pubmed/7923172
type: PublicationXref
id: 7923172
author: Momparler, RL
author: Laliberte, J
db: Pubmed
title: Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA
source: Cancer Res 54:5401-7
year: 1994

80S:Met-tRNAi:mRNA:eIF5B:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2661
component stoichiometry: Stoichiometry2659
component stoichiometry: Stoichiometry2656
component stoichiometry: Stoichiometry2660
component: eIF5B:GTP (name copied from entity in Homo sapiens)
component: 80S ribosome (name copied from entity in Homo sapiens)
component: PhysicalEntity326
component: PhysicalEntity319
xref: UnificationXref12101
cellular location: GO:0005829
comment: Reactome DB_ID: 3641766

UnificationXref6650
type: UnificationXref
id: CHEBI:63830
db: ChEBI

eIF4A subunits complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2649
component stoichiometry: Stoichiometry2648
component: PhysicalEntity324
component: PhysicalEntity323
xref: UnificationXref12086
cellular location: GO:0005829
comment: Reactome DB_ID: 3641515

UnificationXref6651
type: UnificationXref
id: 193707
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193707

UnificationXref6666
type: UnificationXref
id: 3644547
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644547

UnificationXref6665
type: UnificationXref
id: REACT_10192
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10192.1

UnificationXref6668
type: UnificationXref
id: CHEBI:63831
db: ChEBI

UnificationXref6667
type: UnificationXref
id: REACT_112160
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112160.8

UnificationXref6669
type: UnificationXref
id: 213285
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=213285

http://identifiers.org/pubmed/20435355
type: PublicationXref
id: 20435355
author: Palczewski, Krzysztof
db: Pubmed
title: Retinoids for treatment of retinal diseases
source: Trends Pharmacol. Sci. 31:284-95
year: 2010

http://identifiers.org/pubmed/20462400
type: PublicationXref
id: 20462400
author: Henley, Jeremy M
author: Wilkinson, Kevin A
db: Pubmed
title: Mechanisms, regulation and consequences of protein SUMOylation
source: Biochem. J. 428:133-45
year: 2010

Ensembl:DDB0205980
type: ProteinReference
xref: UnificationXref8879
organism: Dictyostelium discoideum

TFIIIB:TFIIIC:Type 2 Promoter Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2607
component stoichiometry: Stoichiometry2608
component: TFIIIC:Type 2 Promoter Complex (name copied from entity in Homo sapiens)
component: TFIIIB-Type 1 and 2 Promoter Selective Complex (name copied from entity in Homo sapiens)
xref: UnificationXref11974
cellular location: GO:0005654
comment: Reactome DB_ID: 3643169

RNA Polymerase III:TFIIIB:TFIIIC:Type 2 Promoter Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2610
component stoichiometry: Stoichiometry2609
component: TFIIIB:TFIIIC:Type 2 Promoter Complex (name copied from entity in Homo sapiens)
component: RNA Polymerase III Holoenzyme (name copied from entity in Homo sapiens)
xref: UnificationXref11975
cellular location: GO:0005654
comment: Reactome DB_ID: 3643170

Elongating RNA Polymerase III Transcription Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2604
component stoichiometry: Stoichiometry2603
component: RNA Polymerase III Holoenzyme (name copied from entity in Homo sapiens)
component: PhysicalEntity313
xref: UnificationXref11966
cellular location: GO:0005654
comment: Reactome DB_ID: 3643259

TFIIIB-Type 1 and 2 Promoter Selective Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2599
component stoichiometry: Stoichiometry2600
component stoichiometry: Stoichiometry2601
component: Protein2700
component: PhysicalEntity288
component: Protein2699
xref: UnificationXref11956
cellular location: GO:0005654
comment: Reactome DB_ID: 3643150

UniProt:Q55GV3
type: ProteinReference
xref: UnificationXref507
organism: Dictyostelium discoideum

eIF2 subunit complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2623
component stoichiometry: Stoichiometry2622
component stoichiometry: Stoichiometry2621
component: Protein2702
component: Protein2703
component: Protein2704
xref: UnificationXref12040
cellular location: GO:0005829
comment: Reactome DB_ID: 3641508

http://identifiers.org/pubmed/12375236
type: PublicationXref
id: 12375236
author: McDonnell, Maeve
author: Whitehead, Alexander S
author: Hoess, Katy
author: Doolin, Marie-Therese
author: Mitchell, Laura E
author: Barbaux, Sandrine
db: Pubmed
title: Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida
source: Am. J. Hum. Genet. 71:1222-6
year: 2002

multiubiquitinated Cyclin A associated with MCC:APC/C complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2618
component stoichiometry: Stoichiometry2619
component: Cdc2:Cyclin A:MCC:APC/C complex (name copied from entity in Homo sapiens)
component: Protein217
xref: UnificationXref12027
cellular location: GO:0005829
comment: Reactome DB_ID: 3644018

UnificationXref6660
type: UnificationXref
id: REACT_10353
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10353.1

Cdc2:Cyclin A:MCC:APC/C complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2616
component stoichiometry: Stoichiometry2615
component: Cyclin A:phospho-Cdc2(Thr 161) complex (name copied from entity in Homo sapiens)
component: Complex313
xref: UnificationXref12024
cellular location: GO:0005829
comment: Reactome DB_ID: 3644017

UnificationXref6661
type: UnificationXref
id: 3644544
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644544

Cyclin A:phospho-Cdc2(Thr 161) complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2614
component stoichiometry: Stoichiometry2613
component: Protein1181
component: Protein580
xref: UnificationXref12023
cellular location: GO:0005829
comment: Reactome DB_ID: 3644016

UnificationXref6662
type: UnificationXref
id: REACT_84586
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_84586.9

Paused RNA Polymerase III Transcription Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2611
component stoichiometry: Stoichiometry2612
component: PhysicalEntity317
component: RNA Polymerase III Holoenzyme (name copied from entity in Homo sapiens)
xref: UnificationXref11989
cellular location: GO:0005654
comment: Reactome DB_ID: 3643262

UnificationXref6663
type: UnificationXref
id: CHEBI:17278
db: ChEBI

TFIIIC:Type 2 Promoter Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2606
component stoichiometry: Stoichiometry2605
component: TFIIIC (name copied from entity in Homo sapiens)
component: PhysicalEntity315
xref: UnificationXref11973
cellular location: GO:0005654
comment: Reactome DB_ID: 3643168

UnificationXref6664
type: UnificationXref
id: 193728
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193728

UnificationXref6679
type: UnificationXref
id: 193829
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193829

UnificationXref6678
type: UnificationXref
id: CHEBI:48834
db: ChEBI

UnificationXref6677
type: UnificationXref
id: REACT_10863
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10863.1

PublicationXref2765
type: PublicationXref
id: 9780120884650
author: Evan Jones, R
author: López, KH
db: ISBN
title: Human reproductive biology
source: Human reproductive biology (Book)
year: 2006

UnificationXref6676
type: UnificationXref
id: 193813
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193813

Signal Recognition Particle (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2744
component stoichiometry: Stoichiometry2742
component stoichiometry: Stoichiometry2748
component stoichiometry: Stoichiometry2745
component stoichiometry: Stoichiometry2747
component stoichiometry: Stoichiometry2743
component stoichiometry: Stoichiometry2746
component: Protein2723
component: Protein2725
component: PhysicalEntity330
component: Protein2726
component: Protein2722
component: Protein2727
component: Protein2724
xref: UnificationXref12163
cellular location: GO:0005829
comment: Reactome DB_ID: 3650351

SRP receptor (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2751
component stoichiometry: Stoichiometry2752
component: Protein2728
component: Protein2729
xref: UnificationXref12171
cellular location: GO:0005789
comment: Reactome DB_ID: 3650323

SRP:polypeptide+signal:ribosome (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2749
component stoichiometry: Stoichiometry2750
component: ribosome:mRNA:polypeptide+signal (name copied from entity in Homo sapiens)
component: Signal Recognition Particle (name copied from entity in Homo sapiens)
xref: UnificationXref12164
cellular location: GO:0005829
comment: Reactome DB_ID: 3650353

Translocon:TRAP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2762
component stoichiometry: Stoichiometry2760
component stoichiometry: Stoichiometry2758
component stoichiometry: Stoichiometry2761
component stoichiometry: Stoichiometry2759
component stoichiometry: Stoichiometry2767
component: Protein2736
component: Protein2735
component: Translocon (name copied from entity in Homo sapiens)
component: Protein2734
component: TRAP Complex (name copied from entity in Homo sapiens)
component: PhysicalEntity331
xref: UnificationXref12194
cellular location: GO:0005789
comment: Reactome DB_ID: 3650380

SRP receptor:SRP:ribosome:polypeptide+signal (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2754
component stoichiometry: Stoichiometry2753
component: SRP receptor (name copied from entity in Homo sapiens)
component: SRP:polypeptide+signal:ribosome (name copied from entity in Homo sapiens)
xref: UnificationXref12172
cellular location: GO:0005789
comment: Reactome DB_ID: 3650354

TRAP Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2766
component stoichiometry: Stoichiometry2765
component stoichiometry: Stoichiometry2763
component stoichiometry: Stoichiometry2764
component: Protein2738
component: Protein2737
component: PhysicalEntity332
component: Protein2739
xref: UnificationXref12193
cellular location: GO:0005789
comment: Reactome DB_ID: 3650364

Translocon (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2755
component stoichiometry: Stoichiometry2756
component stoichiometry: Stoichiometry2757
component: Protein2730
component: Protein2732
component: Protein2733
xref: UnificationXref12179
cellular location: GO:0005789
comment: Reactome DB_ID: 3650369

membrane-bound ribosome:mRNA:polypeptide+signal (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2769
component stoichiometry: Stoichiometry2770
component stoichiometry: Stoichiometry2771
component: PhysicalEntity333
component: 80S ribosome (name copied from entity in Homo sapiens)
component: PhysicalEntity326
xref: UnificationXref12197
cellular location: GO:0005789
comment: Reactome DB_ID: 3650381

UnificationXref6674
type: UnificationXref
id: REACT_112535
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112535.8

polypeptide+signal:Translocon (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2768
component stoichiometry: Stoichiometry2772
component: membrane-bound ribosome:mRNA:polypeptide+signal (name copied from entity in Homo sapiens)
component: Translocon:TRAP (name copied from entity in Homo sapiens)
xref: UnificationXref12198
cellular location: GO:0005789
comment: Reactome DB_ID: 3650382

UnificationXref6675
type: UnificationXref
id: CHEBI:48333
db: ChEBI

UnificationXref6672
type: UnificationXref
id: REACT_144124
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144124.5

cleaved polypeptide:Translocon (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2773
component stoichiometry: Stoichiometry2777
component: membrane-bound ribosome:mRNA:cleaved polypeptide (name copied from entity in Homo sapiens)
component: Translocon:TRAP (name copied from entity in Homo sapiens)
xref: UnificationXref12206
cellular location: GO:0005789
comment: Reactome DB_ID: 3650385

UnificationXref6673
type: UnificationXref
id: 3652042
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652042

UnificationXref6670
type: UnificationXref
id: REACT_13314
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13314.1

UnificationXref6671
type: UnificationXref
id: 3644546
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644546

Regulation of PLK1 Activity at G2/M Transition
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction354
evidence: Evidence618
xref: UnificationXref4639
xref: UnificationXref4638
pathway order: PathwayStep603
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref2406
type: UnificationXref
id: 3644515
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644515

UnificationXref2405
type: UnificationXref
id: Q1ZXA4
db: UniProt

UnificationXref2408
type: UnificationXref
id: 3644516
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644516

UnificationXref2407
type: UnificationXref
id: Q1ZXL2
db: UniProt

UnificationXref6688
type: UnificationXref
id: REACT_10201
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10201.1

UnificationXref2409
type: UnificationXref
id: Q54E98
db: UniProt

UnificationXref6687
type: UnificationXref
id: 193830
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193830

UnificationXref6689
type: UnificationXref
id: 3644550
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644550

Ensembl:DDB0204862
type: ProteinReference
xref: UnificationXref8643
organism: Dictyostelium discoideum

UnificationXref2400
type: UnificationXref
id: 3644512
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644512

UnificationXref2402
type: UnificationXref
id: 3644513
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644513

UnificationXref2401
type: UnificationXref
id: Q54QD0
db: UniProt

UnificationXref2404
type: UnificationXref
id: 3644514
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644514

UnificationXref2403
type: UnificationXref
id: Q1ZXA1
db: UniProt

80S:Met-tRNAi:mRNA (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2665
component stoichiometry: Stoichiometry2666
component stoichiometry: Stoichiometry2664
component: 80S ribosome (name copied from entity in Homo sapiens)
component: PhysicalEntity326
component: PhysicalEntity319
xref: UnificationXref12103
cellular location: GO:0005829
comment: Reactome DB_ID: 3641768

Ensembl:DDB0189361
type: ProteinReference
xref: UnificationXref8673
organism: Dictyostelium discoideum

eIF5B:GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2663
component stoichiometry: Stoichiometry2662
component: SmallMolecule2
component: Protein2715
xref: UnificationXref12102
cellular location: GO:0005829
comment: Reactome DB_ID: 3641767

Ensembl:DDB0185283
type: ProteinReference
xref: UnificationXref8680
organism: Dictyostelium discoideum

eIF2:GDP: eIF2B (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2678
component stoichiometry: Stoichiometry2677
component stoichiometry: Stoichiometry2679
component: eIF2B subunits complex (name copied from entity in Homo sapiens)
component: SmallMolecule2
component: eIF2 subunit complex (name copied from entity in Homo sapiens)
xref: UnificationXref12123
cellular location: GO:0005829
comment: Reactome DB_ID: 3641563

Ensembl:DDB0231517
type: ProteinReference
xref: UnificationXref8712
organism: Dictyostelium discoideum

eIF2:GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2675
component stoichiometry: Stoichiometry2676
component: SmallMolecule2
component: eIF2 subunit complex (name copied from entity in Homo sapiens)
xref: UnificationXref12122
cellular location: GO:0005829
comment: Reactome DB_ID: 3641530

eIF2B subunits complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2670
component stoichiometry: Stoichiometry2671
component stoichiometry: Stoichiometry2674
component stoichiometry: Stoichiometry2673
component stoichiometry: Stoichiometry2672
component: Protein2716
component: Protein2717
component: Protein2720
component: Protein2719
component: Protein2718
xref: UnificationXref12121
cellular location: GO:0005829
comment: Reactome DB_ID: 3641562

Ensembl:DDB0231514
type: ProteinReference
xref: UnificationXref8696
organism: Dictyostelium discoideum

40S:Met-tRNAi:mRNA (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2667
component stoichiometry: Stoichiometry2668
component stoichiometry: Stoichiometry2669
component: PhysicalEntity326
component: 40S ribosomal complex (name copied from entity in Homo sapiens)
component: PhysicalEntity319
xref: UnificationXref12106
cellular location: GO:0005829
comment: Reactome DB_ID: 3641529

ribosome:mRNA:polypeptide+signal (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2741
component stoichiometry: Stoichiometry2740
component stoichiometry: Stoichiometry2739
component: 80S ribosome (name copied from entity in Homo sapiens)
component: PhysicalEntity326
component: PhysicalEntity329
xref: UnificationXref12147
cellular location: GO:0005829
comment: Reactome DB_ID: 3650352

UnificationXref6683
type: UnificationXref
id: CHEBI:48825
db: ChEBI

http://identifiers.org/pubmed/10648173
type: PublicationXref
id: 10648173
author: Menear, K
author: Baldock, D
author: Graff, P
author: Jones, CE
author: Akhlaq, M
author: Graham, B
db: Pubmed
title: Purification and characterization of human Syk produced using a baculovirus expression system
source: Protein Expr Purif 18:86-94
year: 2000

phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2738
component stoichiometry: Stoichiometry2737
component: 43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP (name copied from entity in Homo sapiens)
component: Protein2721
xref: UnificationXref12138
cellular location: GO:0005829
comment: Reactome DB_ID: 3643467

UnificationXref6684
type: UnificationXref
id: 193835
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193835

http://identifiers.org/pubmed/19261456
type: PublicationXref
id: 19261456
author: Procko, E
author: Gaudet, R
db: Pubmed
title: Antigen processing and presentation: TAPping into ABC transporters
source: Curr Opin Immunol 21:84-91
year: 2009

43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2734
component stoichiometry: Stoichiometry2735
component stoichiometry: Stoichiometry2732
component stoichiometry: Stoichiometry2736
component stoichiometry: Stoichiometry2731
component stoichiometry: Stoichiometry2733
component: PhysicalEntity322
component: PhysicalEntity325
component: eIF4F (name copied from entity in Homo sapiens)
component: 43S complex (name copied from entity in Homo sapiens)
component: Protein2269
component: PhysicalEntity328
xref: UnificationXref12136
cellular location: GO:0005829
comment: Reactome DB_ID: 3643466

UnificationXref6685
type: UnificationXref
id: REACT_10821
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10821.1

60s ribosomal complex lacking L13a subunit (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2726
component stoichiometry: Stoichiometry2688
component stoichiometry: Stoichiometry2720
component stoichiometry: Stoichiometry2710
component stoichiometry: Stoichiometry2701
component stoichiometry: Stoichiometry2713
component stoichiometry: Stoichiometry2718
component stoichiometry: Stoichiometry2704
component stoichiometry: Stoichiometry2686
component stoichiometry: Stoichiometry2693
component stoichiometry: Stoichiometry2707
component stoichiometry: Stoichiometry2692
component stoichiometry: Stoichiometry2709
component stoichiometry: Stoichiometry2719
component stoichiometry: Stoichiometry2714
component stoichiometry: Stoichiometry2724
component stoichiometry: Stoichiometry2699
component stoichiometry: Stoichiometry2722
component stoichiometry: Stoichiometry2691
component stoichiometry: Stoichiometry2695
component stoichiometry: Stoichiometry2727
component stoichiometry: Stoichiometry2689
component stoichiometry: Stoichiometry2730
component stoichiometry: Stoichiometry2716
component stoichiometry: Stoichiometry2694
component stoichiometry: Stoichiometry2712
component stoichiometry: Stoichiometry2680
component stoichiometry: Stoichiometry2683
component stoichiometry: Stoichiometry2682
component stoichiometry: Stoichiometry2703
component stoichiometry: Stoichiometry2723
component stoichiometry: Stoichiometry2681
component stoichiometry: Stoichiometry2690
component stoichiometry: Stoichiometry2687
component stoichiometry: Stoichiometry2706
component stoichiometry: Stoichiometry2729
component stoichiometry: Stoichiometry2684
component stoichiometry: Stoichiometry2717
component stoichiometry: Stoichiometry2685
component stoichiometry: Stoichiometry2715
component stoichiometry: Stoichiometry2708
component stoichiometry: Stoichiometry2697
component stoichiometry: Stoichiometry2702
component stoichiometry: Stoichiometry2721
component stoichiometry: Stoichiometry2696
component stoichiometry: Stoichiometry2728
component stoichiometry: Stoichiometry2711
component stoichiometry: Stoichiometry2700
component stoichiometry: Stoichiometry2698
component stoichiometry: Stoichiometry2705
component stoichiometry: Stoichiometry2725
component: Protein2274
component: Protein2304
component: Protein2285
component: Protein2291
component: Protein2296
component: Protein2282
component: Protein2283
component: Protein2305
component: Protein2318
component: Protein2293
component: PhysicalEntity257
component: Protein2300
component: Protein2302
component: Protein2278
component: PhysicalEntity255
component: Protein2299
component: Protein2284
component: Protein2295
component: PhysicalEntity256
component: Protein2313
component: Protein2320
component: Protein2279
component: Protein2289
component: Protein2287
component: Protein2288
component: Protein2310
component: Protein2286

UnificationXref6686
type: UnificationXref
id: CHEBI:48778
db: ChEBI

UnificationXref6680
type: UnificationXref
id: REACT_10380
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10380.2

UnificationXref6681
type: UnificationXref
id: 3644549
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644549

UnificationXref6682
type: UnificationXref
id: REACT_118242
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118242.7

eRF3-GDP:eRF1:80S Ribosome:mRNA:tRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2800
component stoichiometry: Stoichiometry2801
component stoichiometry: Stoichiometry2798
component stoichiometry: Stoichiometry2799
component stoichiometry: Stoichiometry2802
component: GDP bound eRF3 (name copied from entity in Homo sapiens)
component: 80S ribosome (name copied from entity in Homo sapiens)
component: PhysicalEntity326
component: SmallMolecule1138
component: Protein2272
xref: UnificationXref12310
cellular location: GO:0005829
comment: Reactome DB_ID: 3643422

Calmodulin:CaMK IV (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry361
component stoichiometry: Stoichiometry360
component: Active Calmodulin (name copied from entity in Homo sapiens)
component: Protein508
xref: UnificationXref1528
cellular location: GO:0005829
comment: Reactome DB_ID: 3643007

Prefoldin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2807
component stoichiometry: Stoichiometry2804
component stoichiometry: Stoichiometry2808
component stoichiometry: Stoichiometry2803
component stoichiometry: Stoichiometry2805
component stoichiometry: Stoichiometry2806
component: Protein2753
component: Protein2755
component: Protein2756
component: Protein2757
component: Protein2758
component: Protein2754
xref: UnificationXref12336
cellular location: GO:0005829
comment: Reactome DB_ID: 3646656

membrane-bound ribosome:mRNA:cleaved polypeptide (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2775
component stoichiometry: Stoichiometry2774
component stoichiometry: Stoichiometry2776
component: 80S ribosome (name copied from entity in Homo sapiens)
component: PhysicalEntity326
component: PhysicalEntity335
xref: UnificationXref12205
cellular location: GO:0005789
comment: Reactome DB_ID: 3650384

UnificationXref2381
type: UnificationXref
id: REACT_89387
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89387.9

PAK1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry340
component: Protein165
xref: UnificationXref1372
cellular location: GO:0005829
comment: Reactome DB_ID: 3647582

Signal Peptidase (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2780
component stoichiometry: Stoichiometry2781
component stoichiometry: Stoichiometry2782
component stoichiometry: Stoichiometry2778
component stoichiometry: Stoichiometry2779
component: Protein2742
component: Protein2744
component: Protein2743
component: Protein2740
component: Protein2741
xref: UnificationXref12216
cellular location: GO:0005789
comment: Reactome DB_ID: 3650403

UnificationXref2380
type: UnificationXref
id: 3652046
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652046

RAC1/CDC42:PAK dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry342
component stoichiometry: Stoichiometry341
component: Active RAC1/CDC42
component: PAK1 dimer (name copied from entity in Homo sapiens)
xref: UnificationXref1373
cellular location: GO:0005829
comment: Reactome DB_ID: 3650658

80S:Met-tRNAi:mRNA:aminoacyl-tRNA (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2784
component stoichiometry: Stoichiometry2783
component: 80S:Met-tRNAi:mRNA (name copied from entity in Homo sapiens)
component: SmallMolecule1165
xref: UnificationXref12283
cellular location: GO:0005829
comment: Reactome DB_ID: 3643475

RAC1/CDC42:p-S144,T423-PAK (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry345
component stoichiometry: Stoichiometry344
component: Active RAC1/CDC42
component: Protein440
xref: UnificationXref1380
cellular location: GO:0005829
comment: Reactome DB_ID: 3650659

80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2785
component stoichiometry: Stoichiometry2787
component stoichiometry: Stoichiometry2786
component: 80S ribosome (name copied from entity in Homo sapiens)
component: PhysicalEntity326
component: PhysicalEntity336
xref: UnificationXref12286
cellular location: GO:0005829
comment: Reactome DB_ID: 3643411

Active LIMK1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry347
component: Protein449
xref: UnificationXref1394
cellular location: GO:0005829
comment: Reactome DB_ID: 3646894

eEF2:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2788
component stoichiometry: Stoichiometry2789
component: Protein2745
component: SmallMolecule1
xref: UnificationXref12294
cellular location: GO:0005829
comment: Reactome DB_ID: 3643491

UnificationXref2385
type: UnificationXref
id: CHEBI:15379
db: ChEBI

pCofilin: Active LIMK-1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry348
component stoichiometry: Stoichiometry349
component: Active LIMK1 (name copied from entity in Homo sapiens)
component: Protein450
xref: UnificationXref1398
cellular location: GO:0005829
comment: Reactome DB_ID: 3646900

UniProt:Q55GA4
type: ProteinReference
xref: UnificationXref1916
organism: Dictyostelium discoideum

GTP bound eRF3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2790
component stoichiometry: Stoichiometry2791
component: Protein2355
component: SmallMolecule1
xref: UnificationXref12301
cellular location: GO:0005829
comment: Reactome DB_ID: 3643424

UnificationXref2384
type: UnificationXref
id: REACT_10552
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10552.2

Adenylate cyclase (Mg2+ cofactor) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry352
component stoichiometry: Stoichiometry353
component: SmallMolecule106
component: PhysicalEntity52
xref: UnificationXref1498
cellular location: GO:0005886
comment: Reactome DB_ID: 3643099

eRF3-GTP:eRF1:80S Ribosome:mRNA:peptidyl-tRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2793
component stoichiometry: Stoichiometry2792
component stoichiometry: Stoichiometry2794
component: GTP bound eRF3 (name copied from entity in Homo sapiens)
component: 80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide (name copied from entity in Homo sapiens)
component: Protein2272
xref: UnificationXref12302
cellular location: GO:0005829
comment: Reactome DB_ID: 3643425

UnificationXref2383
type: UnificationXref
id: 193103
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193103

PKA tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry356
component stoichiometry: Stoichiometry355
component: Protein351
component: Protein504
xref: UnificationXref1506
cellular location: GO:0005829
comment: Reactome DB_ID: 3643050

eRF3-GDP:eRF1:80S Ribosome:mRNA:peptidyl-tRNA Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2795
component stoichiometry: Stoichiometry2797
component stoichiometry: Stoichiometry2796
component: 80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide (name copied from entity in Homo sapiens)
component: GDP bound eRF3 (name copied from entity in Homo sapiens)
component: Protein2272
xref: UnificationXref12305
cellular location: GO:0005829
comment: Reactome DB_ID: 3643421

UnificationXref2382
type: UnificationXref
id: CHEBI:16581
db: ChEBI

cAMP:PKA regulatory subunit (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry358
component stoichiometry: Stoichiometry359
component: Protein504
component: SmallMolecule90
xref: UnificationXref1507
cellular location: GO:0005829
comment: Reactome DB_ID: 3643051

UnificationXref2388
type: UnificationXref
id: CHEBI:28750
db: ChEBI

UnificationXref2389
type: UnificationXref
id: 193124
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193124

UnificationXref2386
type: UnificationXref
id: 29368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29368

Ensembl:DDB0187721
type: ProteinReference
xref: UnificationXref8279
organism: Dictyostelium discoideum

UnificationXref2387
type: UnificationXref
id: REACT_5251
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5251.2

Mother filament:branching complex:daughter filament (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry338
component stoichiometry: Stoichiometry339
component: PhysicalEntity50
component: Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin (name copied from entity in Homo sapiens)
xref: UnificationXref1369
cellular location: GO:0005829
comment: Reactome DB_ID: 3650572

CCT/TriC(ADP):Sphingosine kinase 1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2856
component stoichiometry: Stoichiometry2855
component: CCT/TriC(ADP) (name copied from entity in Homo sapiens)
component: Homologues of SPHK1
xref: UnificationXref12383
cellular location: GO:0005829
comment: Reactome DB_ID: 3646771

Mother filament:ARP2/3:actin:GDP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry335
component stoichiometry: Stoichiometry334
component stoichiometry: Stoichiometry331
component: PhysicalEntity50
component: ARP2/3 complex (ATP bound) (name copied from entity in Homo sapiens)
component: Actin:ADP (name copied from entity in Homo sapiens)
xref: UnificationXref1366
cellular location: GO:0005829
comment: Reactome DB_ID: 3650672

Actin:ADP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry332
component stoichiometry: Stoichiometry333
component: SmallMolecule6
component: Protein416
xref: UnificationXref1365
cellular location: GO:0005829
comment: Reactome DB_ID: 3649499

CCT/TriC(ADP)-associated non-native tubulin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2822
component stoichiometry: Stoichiometry2823
component: Protein2767
component: CCT/TriC(ADP) (name copied from entity in Homo sapiens)
xref: UnificationXref12363
cellular location: GO:0005829
comment: Reactome DB_ID: 3646621

ARP3:ATP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry312
component stoichiometry: Stoichiometry313
component: Protein413
component: SmallMolecule5
xref: UnificationXref1310
cellular location: GO:0005829
comment: Reactome DB_ID: 3647467

CCT/TriC(ATP):unfolded tubulin complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2828
component stoichiometry: Stoichiometry2832
component stoichiometry: Stoichiometry2833
component stoichiometry: Stoichiometry2829
component stoichiometry: Stoichiometry2831
component stoichiometry: Stoichiometry2835
component stoichiometry: Stoichiometry2826
component stoichiometry: Stoichiometry2834
component stoichiometry: Stoichiometry2830
component stoichiometry: Stoichiometry2827
component: Protein2762
component: Protein2760
component: Protein2759
component: Protein2765
component: Protein2767
component: SmallMolecule5
component: Protein2761
component: Protein2766
component: Protein2764
component: Protein2763
xref: UnificationXref12364
cellular location: GO:0005829
comment: Reactome DB_ID: 3646605

ARP2:ATP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry317
component stoichiometry: Stoichiometry316
component: Protein415
component: SmallMolecule5
xref: UnificationXref1315
cellular location: GO:0005829
comment: Reactome DB_ID: 3647472

CCT/TriC(ADP) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2818
component stoichiometry: Stoichiometry2813
component stoichiometry: Stoichiometry2816
component stoichiometry: Stoichiometry2812
component stoichiometry: Stoichiometry2819
component stoichiometry: Stoichiometry2814
component stoichiometry: Stoichiometry2817
component stoichiometry: Stoichiometry2815
component stoichiometry: Stoichiometry2811
component: Protein2762
component: SmallMolecule6
component: Protein2760
component: Protein2759
component: Protein2765
component: Protein2761
component: Protein2766
component: Protein2764
component: Protein2763
xref: UnificationXref12356
cellular location: GO:0005829
comment: Reactome DB_ID: 3646606

UnificationXref2370
type: UnificationXref
id: REACT_10773
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10773.2

CDC42-GTP:WASP/N-WASP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry306
component stoichiometry: Stoichiometry307
component stoichiometry: Stoichiometry305
component: Protein406
component: CDC42:GTP (name copied from entity in Homo sapiens)
component: SmallMolecule12
xref: UnificationXref1297
cellular location: GO:0005829
comment: Reactome DB_ID: 3647441

actin/tubulin-bound CCT/TriC(ADP) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2821
component stoichiometry: Stoichiometry2820
component: CCT/TriC(ADP) (name copied from entity in Homo sapiens)
component: PhysicalEntity338
xref: UnificationXref12357
cellular location: GO:0005829
comment: Reactome DB_ID: 3646736

ARP2/3 complex (ATP bound) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry311
component stoichiometry: Stoichiometry315
component stoichiometry: Stoichiometry314
component stoichiometry: Stoichiometry309
component stoichiometry: Stoichiometry308
component stoichiometry: Stoichiometry310
component stoichiometry: Stoichiometry318
component: Protein414
component: Protein409
component: ARP2:ATP (name copied from entity in Homo sapiens)
component: Protein412
component: ARP3:ATP (name copied from entity in Homo sapiens)
component: Protein410
component: Protein411
xref: UnificationXref1316
cellular location: GO:0005829
comment: Reactome DB_ID: 3647473

CCT/TriC(ATP)-associated actin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2852
component stoichiometry: Stoichiometry2842
component: CCT/TriC(ATP) (name copied from entity in Homo sapiens)
component: Protein416
xref: UnificationXref12374
cellular location: GO:0005829
comment: Reactome DB_ID: 3646758

UnificationXref2372
type: UnificationXref
id: 3644862
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644862

Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry327
component stoichiometry: Stoichiometry328
component stoichiometry: Stoichiometry326
component: CDC42-GTP:p-WASP/p-N-WASP:WIP:SH3 proteins (name copied from entity in Homo sapiens)
component: ARP2/3 complex (ATP bound) (name copied from entity in Homo sapiens)
component: G-actin (name copied from entity in Homo sapiens)
xref: UnificationXref1358
cellular location: GO:0005829
comment: Reactome DB_ID: 3647498

CCT/TriC(ATP) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2845
component stoichiometry: Stoichiometry2844
component stoichiometry: Stoichiometry2851
component stoichiometry: Stoichiometry2847
component stoichiometry: Stoichiometry2848
component stoichiometry: Stoichiometry2843
component stoichiometry: Stoichiometry2846
component stoichiometry: Stoichiometry2850
component stoichiometry: Stoichiometry2849
component: Protein2762
component: Protein2760
component: Protein2759
component: Protein2765
component: SmallMolecule5
component: Protein2761
component: Protein2766
component: Protein2764
component: Protein2763
xref: UnificationXref12373
cellular location: GO:0005829
comment: Reactome DB_ID: 3646757

UnificationXref2371
type: UnificationXref
id: Q54NZ7
db: UniProt

Mother filament:branching complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry329
component stoichiometry: Stoichiometry330
component: PhysicalEntity50
component: Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin (name copied from entity in Homo sapiens)
xref: UnificationXref1362
cellular location: GO:0005829
comment: Reactome DB_ID: 3650664

tubulin-GTP folding intermediate (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2838
component stoichiometry: Stoichiometry2837
component: Protein2767
component: SmallMolecule1
xref: UnificationXref12367
cellular location: GO:0005829
comment: Reactome DB_ID: 3646607

UnificationXref2374
type: UnificationXref
id: 3644863
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644863

G-actin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry320
component stoichiometry: Stoichiometry319
component: Protein416
component: SmallMolecule5
xref: UnificationXref1340
cellular location: GO:0005829
comment: Reactome DB_ID: 3647497

CCT/TriC (ADP) associated actin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2840
component stoichiometry: Stoichiometry2839
component: Protein416
component: CCT/TriC(ADP) (name copied from entity in Homo sapiens)
xref: UnificationXref12372
cellular location: GO:0005829
comment: Reactome DB_ID: 3646760

UnificationXref2373
type: UnificationXref
id: Q55FL3
db: UniProt

CDC42-GTP:p-WASP/p-N-WASP:WIP:SH3 proteins (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry323
component stoichiometry: Stoichiometry325
component stoichiometry: Stoichiometry322
component stoichiometry: Stoichiometry321
component stoichiometry: Stoichiometry324
component: PhysicalEntity49
component: CDC42:GTP (name copied from entity in Homo sapiens)
component: Protein428
component: SmallMolecule12
component: PhysicalEntity48
xref: UnificationXref1357
cellular location: GO:0005829
comment: Reactome DB_ID: 3647496

UnificationXref2375
type: UnificationXref
id: Q6IMN8
db: UniProt

UnificationXref2376
type: UnificationXref
id: 3644864
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644864

Gap-filling DNA repair synthesis and ligation in GG-NER
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction275
evidence: Evidence480
xref: RelationshipXref298
xref: UnificationXref4056
xref: UnificationXref4057
pathway order: PathwayStep467
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference46
data source: Provenance1
name: AMPK beta2
name: DDB0237814
xref: UnificationXref7885
feature: FragmentFeature1611
cellular location: GO:0005654
comment: Reactome DB_ID: 3643639
display name: PRKAB2

UnificationXref2377
type: UnificationXref
id: 3644865
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644865

http://identifiers.org/pubmed/9949182
type: PublicationXref
id: 9949182
author: Pébusque, MJ
author: Grégoire, MJ
author: Zhang, B
author: Jonveaux, P
author: Popovici, C
author: Lafage-Pochitaloff, M
author: Birnbaum, D
db: Pubmed
title: The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
source: Blood 93:1381-9
year: 1999

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q8T277
data source: Provenance1
name: Q8T277
name: AMPK gamma2
xref: UnificationXref7886
feature: FragmentFeature1612
cellular location: GO:0005654
comment: Reactome DB_ID: 3643643
display name: PRKAG2

UnificationXref2378
type: UnificationXref
id: 3644867
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644867

Prefoldin-associated actin/tubulin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry2809
component stoichiometry: Stoichiometry2810
component: Prefoldin (name copied from entity in Homo sapiens)
component: PhysicalEntity338
xref: UnificationXref12337
cellular location: GO:0005829
comment: Reactome DB_ID: 3646735

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54YF2
data source: Provenance1
name: Q54YF2
name: AMPK alpha2
xref: UnificationXref7887
feature: FragmentFeature1613
cellular location: GO:0005654
comment: Reactome DB_ID: 3643635
display name: PRKAA2

UnificationXref2379
type: UnificationXref
id: REACT_107357
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107357.9

phospho-p-T172-PRKAA2
type: Protein
entity reference: Q54YF2
data source: Provenance1
xref: UnificationXref7895
feature: ModificationFeature12
feature: FragmentFeature1614
cellular location: GO:0005654
comment: Reactome DB_ID: 3643674

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54WJ0
data source: Provenance1
name: Q54WJ0
name: STK11(1-433)
xref: UnificationXref7898
feature: FragmentFeature1615
cellular location: GO:0005654
comment: Reactome DB_ID: 3643679
display name: LKB-1

ACC
type: Protein
data source: Provenance1
member physical entity: Protein1555
member physical entity: Protein1530
xref: UnificationXref7905
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3643650

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q94465
data source: Provenance1
name: Q94465
name: GTP cyclohydrolase 1
name: GCH1_HUMAN
xref: UnificationXref7918
feature: FragmentFeature1616
cellular location: GO:0005829
comment: Reactome DB_ID: 3649579
display name: GCH1

phospho-p-S19-PTS
type: Protein
entity reference: Q1ZXI0
data source: Provenance1
xref: UnificationXref7935
feature: FragmentFeature1617
feature: ModificationFeature196
cellular location: GO:0005829
comment: Reactome DB_ID: 3649590

phospho-p-S213-SPR
type: Protein
entity reference: Q54GP3
data source: Provenance1
xref: UnificationXref7940
feature: ModificationFeature197
feature: FragmentFeature1618
cellular location: GO:0005829
comment: Reactome DB_ID: 3649598

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54LA0
data source: Provenance1
name: Dihydrofolate reductase
name: DYR_HUMAN
name: Q54LA0
xref: UnificationXref7952
feature: FragmentFeature1619
cellular location: GO:0005829
comment: Reactome DB_ID: 3644962
display name: DHFR

http://identifiers.org/pubmed/4358634
type: PublicationXref
id: 4358634
author: Roth, DG
author: Deuel, TF
author: Shelton, E
db: Pubmed
title: Purification and properties of phosphoribosyl pyrophosphate synthetase from rat liver
source: J Biol Chem 249:291-296
year: 1974

ISG15:UBE1L (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry403
component stoichiometry: Stoichiometry402
component: Protein213
component: Protein387
xref: UnificationXref1634
cellular location: GO:0005829
comment: Reactome DB_ID: 3649229

pPLCgamma:PIP2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry404
component stoichiometry: Stoichiometry405
component: Protein545
component: SmallMolecule12
xref: UnificationXref1652
cellular location: GO:0005886
comment: Reactome DB_ID: 3648148

pPAK1:Rac1-GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry407
component stoichiometry: Stoichiometry408
component: RAC1-GTP (name copied from entity in Homo sapiens)
component: Protein440
xref: UnificationXref1659
cellular location: GO:0005829
comment: Reactome DB_ID: 3647593

Ensembl:DDB0305158
type: ProteinReference
xref: UnificationXref8076
organism: Dictyostelium discoideum

CaN catalytic alpha/beta:Zn++:Fe3+:CaM:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry387
component stoichiometry: Stoichiometry391
component: Active Calmodulin (name copied from entity in Homo sapiens)
component: CaN catalytic alpha/beta:Zn++:Fe3+ (name copied from entity in Homo sapiens)
xref: UnificationXref1610
cellular location: GO:0005654
comment: Reactome DB_ID: 3651484

CaN catalytic alpha/beta:Zn++:Fe3+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry388
component stoichiometry: Stoichiometry389
component stoichiometry: Stoichiometry390
component: SmallMolecule111
component: SmallMolecule110
component: Protein540
xref: UnificationXref1609
cellular location: GO:0005654
comment: Reactome DB_ID: 3651483

RasGRPs:DAG:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry395
component stoichiometry: Stoichiometry396
component stoichiometry: Stoichiometry397
component: SmallMolecule16
component: Protein543
component: SmallMolecule22
xref: UnificationXref1619
cellular location: GO:0005886
comment: Reactome DB_ID: 3651490

p-5Y-PKC-theta:DAG (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry400
component stoichiometry: Stoichiometry399
component: SmallMolecule16
component: Protein544
xref: UnificationXref1623
cellular location: GO:0005886
comment: Reactome DB_ID: 3651461

NFAT:CaN:CaM (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry394
component stoichiometry: Stoichiometry393
component: PhysicalEntity54
component: CaN:CaM:Ca2+ (name copied from entity in Homo sapiens)
xref: UnificationXref1613
cellular location: GO:0005654
comment: Reactome DB_ID: 3651487

CaN alpha regulatory:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry385
component stoichiometry: Stoichiometry384
component: SmallMolecule107
component: Protein539
xref: UnificationXref1601
cellular location: GO:0005654
comment: Reactome DB_ID: 3651479

CaN:CaM:Ca2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry392
component stoichiometry: Stoichiometry386
component: CaN catalytic alpha/beta:Zn++:Fe3+:CaM:Ca2+ (name copied from entity in Homo sapiens)
component: CaN alpha regulatory:Ca2+ (name copied from entity in Homo sapiens)
xref: UnificationXref1611
cellular location: GO:0005654
comment: Reactome DB_ID: 3651485

http://identifiers.org/pubmed/9874197
type: PublicationXref
id: 9874197
author: Brees, C
author: Van Veldhoven, PP
author: Fransen, M
author: Baes, M
author: Wylin, T
author: Mannaerts, GP
db: Pubmed
title: Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii
source: Eur J Biochem 258:332-8
year: 1998

UniProt:Q55GD6
type: ProteinReference
xref: UnificationXref2166
organism: Dictyostelium discoideum

http://identifiers.org/pubmed/1439791
type: PublicationXref
id: 1439791
author: Cerione, RA
author: Witte, ON
author: Leonard, D
author: Maru, Y
author: Evans, T
author: Hart, MJ
db: Pubmed
title: A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs
source: Science 258:812-5
year: 1992

UnificationXref2394
type: UnificationXref
id: 3644509
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644509

PPP3CA/B:Calmodulin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry380
component stoichiometry: Stoichiometry379
component: Active Calmodulin (name copied from entity in Homo sapiens)
component: PPP3CA/B:Fe3+:Zn2+ (name copied from entity in Homo sapiens)
xref: UnificationXref1594
cellular location: GO:0005829
comment: Reactome DB_ID: 3650641

UniProt:Q55GD9
type: ProteinReference
xref: UnificationXref157
organism: Dictyostelium discoideum

Ensembl:DDB0231372
type: ProteinReference
xref: UnificationXref8010
organism: Dictyostelium discoideum

UnificationXref2393
type: UnificationXref
id: Q54EM5
db: UniProt

NFAT:CaN:CaM (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry383
component stoichiometry: Stoichiometry382
component: PhysicalEntity53
component: Calcineurin:Calmodulin (CaN:CaM) (name copied from entity in Homo sapiens)
xref: UnificationXref1599
cellular location: GO:0005829
comment: Reactome DB_ID: 3651477

UnificationXref2396
type: UnificationXref
id: 3644510
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644510

Calcineurin:Calmodulin (CaN:CaM) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry381
component stoichiometry: Stoichiometry378
component: PPP3CA/B:Calmodulin (name copied from entity in Homo sapiens)
component: Calcineurin alpha regulatory subunit:Calcium (name copied from entity in Homo sapiens)
xref: UnificationXref1595
cellular location: GO:0005829
comment: Reactome DB_ID: 3650642

UnificationXref2395
type: UnificationXref
id: Q86A22
db: UniProt

Calcineurin alpha regulatory subunit:Calcium (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry377
component stoichiometry: Stoichiometry376
component: Protein535
component: SmallMolecule22
xref: UnificationXref1593
cellular location: GO:0005829
comment: Reactome DB_ID: 3650638

UnificationXref2390
type: UnificationXref
id: REACT_10659
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10659.1

Calcineurin (CaN) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry375
component stoichiometry: Stoichiometry371
component: PPP3CA/B:Fe3+:Zn2+ (name copied from entity in Homo sapiens)
component: Protein535
xref: UnificationXref1592
cellular location: GO:0005829
comment: Reactome DB_ID: 3650645

PPP3CA/B:Fe3+:Zn2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry374
component stoichiometry: Stoichiometry373
component stoichiometry: Stoichiometry372
component: SmallMolecule108
component: Protein536
component: SmallMolecule109
xref: UnificationXref1591
cellular location: GO:0005829
comment: Reactome DB_ID: 3650640

UnificationXref2392
type: UnificationXref
id: 3644508
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644508

phospho-CaMK IV:Calmodulin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry368
component stoichiometry: Stoichiometry369
component: active Calmodulin (name copied from entity in Homo sapiens)
component: Protein521
xref: UnificationXref1551
cellular location: GO:0005654
comment: Reactome DB_ID: 3643035

UnificationXref2391
type: UnificationXref
id: Q1ZXN4
db: UniProt

active Calmodulin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry366
component stoichiometry: Stoichiometry367
component: SmallMolecule107
component: Protein514
xref: UnificationXref1544
cellular location: GO:0005654
comment: Reactome DB_ID: 3643034

UniProt:Q55GE2
type: ProteinReference
xref: UnificationXref9385
organism: Dictyostelium discoideum

Active Calmodulin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry362
component stoichiometry: Stoichiometry363
component: SmallMolecule107
component: Protein514
xref: UnificationXref1534
cellular location: GO:0005654
comment: Reactome DB_ID: 3643016

Calmodulin:CaMK IV (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry365
component stoichiometry: Stoichiometry364
component: Active Calmodulin (name copied from entity in Homo sapiens)
component: Protein515
xref: UnificationXref1541
cellular location: GO:0005654
comment: Reactome DB_ID: 3643017

UnificationXref2397
type: UnificationXref
id: Q55AJ4
db: UniProt

UnificationXref2398
type: UnificationXref
id: 3644511
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644511

UnificationXref2399
type: UnificationXref
id: Q54NY3
db: UniProt

http://identifiers.org/pubmed/13679574
type: PublicationXref
id: 13679574
author: Bouvier, M
author: Rousseau, G
author: Angers, S
author: Charest, PG
author: Kohout, T
author: Azzi, M
author: Piñeyro, G
db: Pubmed
title: Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
source: Proc Natl Acad Sci U S A 100:11406-11
year: 2003

CK2 Phosphorylated Condensin I (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry469
component stoichiometry: Stoichiometry468
component stoichiometry: Stoichiometry467
component stoichiometry: Stoichiometry471
component stoichiometry: Stoichiometry470
component: Protein591
component: Protein590
component: Protein592
component: Protein594
component: Protein593
xref: UnificationXref1796
cellular location: GO:0005829
comment: Reactome DB_ID: 3651274

5-Phosphoribose 1-diphosphate biosynthesis
type: Pathway
data source: Provenance1
name: Synthesis of cytosolic 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) from D-ribose 5-phosphate
pathway component: BiochemicalReaction445
pathway component: BiochemicalReaction444
evidence: Evidence754
xref: RelationshipXref437
xref: UnificationXref5510
xref: UnificationXref5509
pathway order: PathwayStep734
pathway order: PathwayStep735
display name: PRPP biosynthesis
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

Condensin I (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry463
component stoichiometry: Stoichiometry462
component stoichiometry: Stoichiometry461
component stoichiometry: Stoichiometry460
component stoichiometry: Stoichiometry464
component: Protein590
component: Protein587
component: Protein586
component: Protein589
component: Protein588
xref: UnificationXref1791
cellular location: GO:0005829
comment: Reactome DB_ID: 3651254

CDK1 Phosphorylated Condensin I (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry482
component stoichiometry: Stoichiometry481
component stoichiometry: Stoichiometry483
component stoichiometry: Stoichiometry479
component stoichiometry: Stoichiometry480
component: Protein590
component: Protein589
component: Protein599
component: Protein598
component: Protein600
xref: UnificationXref1812
cellular location: GO:0005829
comment: Reactome DB_ID: 3651264

Casein kinase II (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry472
component stoichiometry: Stoichiometry473
component stoichiometry: Stoichiometry474
component: Protein595
component: Protein596
component: Protein597
xref: UnificationXref1802
cellular location: GO:0005829
comment: Reactome DB_ID: 3651285

UnificationXref2340
type: UnificationXref
id: REACT_114241
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114241.8

Phosphatidylinositol-3,4,5-trisphosphate
type: SmallMoleculeReference
name: PIP3
name: PtsIns(3,4,5)P3
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]
name: PtsIns-3,4,5-P3
name: 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
xref: UnificationXref10936

UnificationXref2341
type: UnificationXref
id: 112158
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=112158

ESPL1 Autocleaved (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry485
component stoichiometry: Stoichiometry484
component stoichiometry: Stoichiometry486
component: Protein602
component: Protein604
component: Protein603
xref: UnificationXref1824
cellular location: GO:0005829
comment: Reactome DB_ID: 3651164

http://identifiers.org/pubmed/14988808
type: PublicationXref
id: 14988808
author: Jakobs, C
author: Huck, JH
author: Verhoeven, NM
author: van der Knaap, MS
author: Struys, EA
author: Salomons, GS
db: Pubmed
title: Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathy
source: Am J Hum Genet 74:745-51
year: 2004

UnificationXref4480
type: UnificationXref
id: 3640091
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640091

UnificationXref4481
type: UnificationXref
id: 3640092
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640092

http://identifiers.org/pubmed/1550217
type: PublicationXref
id: 1550217
author: Gould, GW
author: Bell, GI
author: Burant, CF
author: Davidson, NO
author: Ifkovits, CA
author: Hausman, AM
author: Buse, JB
db: Pubmed
title: Human intestinal glucose transporter expression and localization of GLUT5
source: Am J Physiol 262:C795-800
year: 1992

UnificationXref4482
type: UnificationXref
id: REACT_86611
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86611.9

UnificationXref4483
type: UnificationXref
id: 3651702
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651702

UnificationXref4484
type: UnificationXref
id: REACT_33489
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33489.10

UnificationXref4485
type: UnificationXref
id: 3651703
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651703

UnificationXref4486
type: UnificationXref
id: REACT_105564
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105564.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54S87
data source: Provenance1
name: LASS4
name: LAG1 homolog, ceramide synthase 4
name: Q54S87
xref: UnificationXref7645
feature: FragmentFeature1590
cellular location: GO:0005789
comment: Reactome DB_ID: 3647137
display name: CERS4

UnificationXref4488
type: UnificationXref
id: REACT_4386
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4386.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54S87
data source: Provenance1
name: LASS3
name: LAG1 homolog, ceramide synthase 3
name: Q54S87
xref: UnificationXref7644
feature: FragmentFeature1589
cellular location: GO:0005789
comment: Reactome DB_ID: 3647136
display name: CERS3

UnificationXref4487
type: UnificationXref
id: 68452
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=68452

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54S87
data source: Provenance1
name: LAG1 homolog, ceramide synthase 2
name: LASS2
name: Q54S87
xref: UnificationXref7643
feature: FragmentFeature1588
cellular location: GO:0005789
comment: Reactome DB_ID: 3647135
display name: CERS2

LAG1 homologs, ceramide synthases
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7648
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3647140
display name: LASS proteins

UnificationXref4489
type: UnificationXref
id: 69172
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69172

sphingosine-1-phosphate phosphatase
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7656
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3647175
display name: SGPP

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54S87
data source: Provenance1
name: LAG1 homolog, ceramide synthase 6
name: LASS6
name: Q54S87
xref: UnificationXref7647
feature: FragmentFeature1592
cellular location: GO:0005789
comment: Reactome DB_ID: 3647139
display name: CERS6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54S87
data source: Provenance1
name: LAG1 homolog, ceramide synthase 5
name: LASS5
name: Q54S87
xref: UnificationXref7646
feature: FragmentFeature1591
cellular location: GO:0005789
comment: Reactome DB_ID: 3647138
display name: CERS5

UnificationXref2345
type: UnificationXref
id: 3642720
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642720

UnificationXref2344
type: UnificationXref
id: 3642719
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642719

UnificationXref2343
type: UnificationXref
id: 3642718
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642718

UnificationXref2342
type: UnificationXref
id: REACT_5389
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5389.1

Ac-Cohesin:PDS5:p-CDCA5:WAPAL (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry440
component stoichiometry: Stoichiometry439
component stoichiometry: Stoichiometry441
component stoichiometry: Stoichiometry442
component: PhysicalEntity57
component: Protein577
component: Ac-Cohesin Complex (name copied from entity in Homo sapiens)
component: PhysicalEntity59
xref: UnificationXref1763
cellular location: GO:0005694
comment: Reactome DB_ID: 3651134

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q86KF9
data source: Provenance1
name: sphingosine kinase 2
name: Q86KF9
xref: UnificationXref7637
feature: FragmentFeature1587
cellular location: GO:0005829
comment: Reactome DB_ID: 3647144
display name: SPHK2

UnificationXref2349
type: UnificationXref
id: REACT_30065
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30065.10

CCNB:p-T161-CDK1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry446
component stoichiometry: Stoichiometry445
component: Protein581
component: Protein580
xref: UnificationXref1769
cellular location: GO:0005829
comment: Reactome DB_ID: 3651200

Q6B516
type: Protein
entity reference: Q6B516
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: sphingosine kinase 2
xref: UnificationXref7636
feature: FragmentFeature1586
cellular location: GO:0005829
comment: Reactome DB_ID: 3647143
display name: SPHK2

UnificationXref2348
type: UnificationXref
id: 3642722
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642722

Sister Chromosomal Arms:p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry458
component stoichiometry: Stoichiometry457
component: p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL (name copied from entity in Homo sapiens)
component: PhysicalEntity58
xref: UnificationXref1776
cellular location: GO:0005694
comment: Reactome DB_ID: 3651142

Homologues of SPHK2
type: Protein
data source: Provenance1
member physical entity: Q6B516
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7638
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3647145

UnificationXref2347
type: UnificationXref
id: 3642721
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642721

p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry455
component stoichiometry: Stoichiometry449
component stoichiometry: Stoichiometry456
component stoichiometry: Stoichiometry448
component: PhysicalEntity57
component: Protein577
component: p-STAG2,RAD21-Ac-Cohesin (name copied from entity in Homo sapiens)
component: PhysicalEntity59
xref: UnificationXref1775
cellular location: GO:0005694
comment: Reactome DB_ID: 3651141

http://identifiers.org/pubmed/9883897
type: PublicationXref
id: 9883897
author: Csere, P
author: Lill, R
author: Kispal, G
db: Pubmed
title: Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p
source: FEBS Lett 441:266-70
year: 1998

UnificationXref2346
type: UnificationXref
id: REACT_112667
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112667.8

p-STAG2,RAD21-Ac-Cohesin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry453
component stoichiometry: Stoichiometry451
component stoichiometry: Stoichiometry452
component stoichiometry: Stoichiometry454
component stoichiometry: Stoichiometry450
component: Protein585
component: Protein584
component: Protein576
component: Protein574
component: Protein575
xref: UnificationXref1774
cellular location: GO:0005694
comment: Reactome DB_ID: 3651140

Ac-Cohesin:PDS5:CDCA5:WAPAL (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry433
component stoichiometry: Stoichiometry427
component stoichiometry: Stoichiometry426
component stoichiometry: Stoichiometry434
component: PhysicalEntity57
component: Protein577
component: Ac-Cohesin Complex (name copied from entity in Homo sapiens)
component: PhysicalEntity56
xref: UnificationXref1758
cellular location: GO:0005694
comment: Reactome DB_ID: 3651198

Sister Chromosomal Arms:Ac-Cohesin:PDS5:CDCA5:WAPAL (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry435
component stoichiometry: Stoichiometry436
component: PhysicalEntity58
component: Ac-Cohesin:PDS5:CDCA5:WAPAL (name copied from entity in Homo sapiens)
xref: UnificationXref1761
cellular location: GO:0005694
comment: Reactome DB_ID: 3651199

p-T161-CDK1:CCNB1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry425
component stoichiometry: Stoichiometry424
component: Protein571
component: Protein570
xref: UnificationXref1733
cellular location: GO:0005654
comment: Reactome DB_ID: 3643906

p-T216,S189,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:PLK1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry421
component stoichiometry: Stoichiometry419
component stoichiometry: Stoichiometry420
component stoichiometry: Stoichiometry418
component: Protein558
component: p-RAB1:GTP (name copied from entity in Homo sapiens)
component: PhysicalEntity55
component: Protein559
xref: UnificationXref1710
cellular location: GO:0000139
comment: Reactome DB_ID: 3650946

Sister Chromosomal Arms:Ac-Cohesin:PDS5:p-CDCA5:WAPAL (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry443
component stoichiometry: Stoichiometry444
component: PhysicalEntity58
component: Ac-Cohesin:PDS5:p-CDCA5:WAPAL (name copied from entity in Homo sapiens)
xref: UnificationXref1764
cellular location: GO:0005694
comment: Reactome DB_ID: 3651135

UnificationXref2330
type: UnificationXref
id: REACT_85243
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85243.9

Ac-Cohesin Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry431
component stoichiometry: Stoichiometry428
component stoichiometry: Stoichiometry429
component stoichiometry: Stoichiometry432
component stoichiometry: Stoichiometry430
component: Protein573
component: Protein576
component: Protein575
component: Protein574
component: Protein572
xref: UnificationXref1753
cellular location: GO:0005694
comment: Reactome DB_ID: 3651125

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q556J2
data source: Provenance1
name: Q556J2
name: 3-ketodihydrosphingosine reductase
xref: UnificationXref7583
feature: FragmentFeature1577
cellular location: GO:0005789
comment: Reactome DB_ID: 3647113
display name: KDSR

UnificationXref4470
type: UnificationXref
id: Q54BN3
db: UniProt

UnificationXref4471
type: UnificationXref
id: 3640072
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640072

UnificationXref4474
type: UnificationXref
id: 3640083
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640083

UnificationXref4475
type: UnificationXref
id: REACT_34250
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34250.10

UnificationXref4472
type: UnificationXref
id: 3640081
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640081

UnificationXref4473
type: UnificationXref
id: 3640082
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640082

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54EX5
data source: Provenance1
name: PXLP-SPTLC3
name: Q54EX5
name: serine palmitoyltransferase 3
xref: UnificationXref7610
feature: FragmentFeature1581
feature: ModificationFeature194
cellular location: GO:0005789
comment: Reactome DB_ID: 3647127
display name: SPTLC3

UnificationXref4479
type: UnificationXref
id: REACT_31925
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31925.10

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54EX5
data source: Provenance1
name: PXLP-SPTLC2
name: Q54EX5
name: serine palmitoyltransferase 2
xref: UnificationXref7608
feature: ModificationFeature193
feature: FragmentFeature1580
cellular location: GO:0005789
comment: Reactome DB_ID: 3647124
display name: SPTLC2

UnificationXref2339
type: UnificationXref
id: 3651873
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651873

UnificationXref4478
type: UnificationXref
id: 3640090
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640090

Q55DQ0
type: Protein
entity reference: UniProt:Q55DQ0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: alkaline ceramidase 3
xref: UnificationXref7622
feature: FragmentFeature1582
cellular location: GO:0005789
comment: Reactome DB_ID: 3647160
display name: ACER3

UnificationXref4477
type: UnificationXref
id: 3640089
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640089

Ensembl:DDB0232174
type: ProteinReference
xref: UnificationXref7744
organism: Dictyostelium discoideum

Homologues of ACER3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q55DQ0
xref: UnificationXref7625
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3647165

UnificationXref4476
type: UnificationXref
id: 3640088
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640088

Homologues of SPHK1
type: Protein
data source: Provenance1
member physical entity: Q6B516
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7635
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3646770

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q6TMJ1
data source: Provenance1
name: alkaline ceramidase 3
name: Q6TMJ1
xref: UnificationXref7624
feature: FragmentFeature1583
cellular location: GO:0005789
comment: Reactome DB_ID: 3647164
display name: ACER3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q86KF9
data source: Provenance1
name: Q86KF9
name: Sphingosine kinase 1
xref: UnificationXref7634
feature: FragmentFeature1585
cellular location: GO:0005829
comment: Reactome DB_ID: 3646769
display name: SPHK1

http://identifiers.org/pubmed/9883880
type: PublicationXref
id: 9883880
author: Callebaut, I
author: Dehoux, P
author: Cossart, P
db: Pubmed
title: EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family
source: FEBS Lett 441:181-5
year: 1998

Q6B516
type: Protein
entity reference: Q6B516
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Sphingosine kinase 1
xref: UnificationXref7632
feature: FragmentFeature1584
cellular location: GO:0005829
comment: Reactome DB_ID: 3646765
display name: SPHK1

UnificationXref2332
type: UnificationXref
id: REACT_2672
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2672.1

UnificationXref2331
type: UnificationXref
id: 110756
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110756

UnificationXref2334
type: UnificationXref
id: DDB0304822
db: Ensembl

UnificationXref2333
type: UnificationXref
id: 3642709
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642709

Ensembl:DDB0184404
type: ProteinReference
xref: UnificationXref7736
organism: Dictyostelium discoideum

UnificationXref2336
type: UnificationXref
id: 3642714
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642714

p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry415
component stoichiometry: Stoichiometry411
component stoichiometry: Stoichiometry412
component: Protein555
component: p-RAB1:GTP (name copied from entity in Homo sapiens)
component: PhysicalEntity55
xref: UnificationXref1705
cellular location: GO:0000139
comment: Reactome DB_ID: 3650942

UnificationXref2335
type: UnificationXref
id: 3642713
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642713

p-RAB1:GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry413
component stoichiometry: Stoichiometry414
component: Protein556
component: SmallMolecule1
xref: UnificationXref1704
cellular location: GO:0000139
comment: Reactome DB_ID: 3650941

Q55FL5
type: Protein
entity reference: UniProt:Q55FL5
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: serine palmitoyltransferase 1
xref: UnificationXref7606
feature: FragmentFeature1579
cellular location: GO:0005789
comment: Reactome DB_ID: 3647119
display name: SPTLC1

UnificationXref2338
type: UnificationXref
id: REACT_106369
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106369.9

GLUT4 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry410
component: Protein136
xref: UnificationXref1691
cellular location: GO:0005886
comment: Reactome DB_ID: 3640258

Ensembl:DDB0233869
type: ProteinReference
xref: UnificationXref7711
organism: Dictyostelium discoideum

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0232045
data source: Provenance1
name: DEGS1(2-323)
name: DDB0232045
name: sphingolipid delta(4)-desaturase 1
name: degenerative spermatocyte homolog 1
xref: UnificationXref7597
feature: FragmentFeature1578
cellular location: GO:0005789
comment: Reactome DB_ID: 3647152
display name: DEGS1

UnificationXref2337
type: UnificationXref
id: 3642715
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642715

p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:PLK1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry416
component stoichiometry: Stoichiometry417
component: Protein558
component: p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP (name copied from entity in Homo sapiens)
xref: UnificationXref1708
cellular location: GO:0000139
comment: Reactome DB_ID: 3650943

UnificationXref2362
type: UnificationXref
id: CHEBI:16474
db: ChEBI

UnificationXref2363
type: UnificationXref
id: 29364
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29364

MPS IIIB - Sanfilippo syndrome B
type: Pathway
data source: Provenance1
pathway component: REACT 131313.5
evidence: Evidence1692
xref: UnificationXref11605
xref: UnificationXref11606
pathway order: PathwayStep758
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref2360
type: UnificationXref
id: 70106
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106

UnificationXref2361
type: UnificationXref
id: REACT_4941
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4941.2

DNA polymerase alpha:primase (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry538
component stoichiometry: Stoichiometry539
component stoichiometry: Stoichiometry541
component stoichiometry: Stoichiometry540
component: Protein628
component: Protein630
component: Protein629
component: PhysicalEntity67
xref: UnificationXref1939
cellular location: GO:0005654
comment: Reactome DB_ID: 3639808

Cdc45:CDK:DDK:Mcm10:pre-replicative complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry537
component stoichiometry: Stoichiometry536
component: CDK:DDK:Mcm10:pre-replicative complex (name copied from entity in Homo sapiens)
component: Protein625
xref: UnificationXref1929
cellular location: GO:0005654
comment: Reactome DB_ID: 3639844

http://identifiers.org/pubmed/14530973
type: PublicationXref
id: 14530973
author: Mackenzie, B
author: Hediger, MA
db: Pubmed
title: SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1
source: Pflugers Arch 447:571-9
year: 2004

DNA polymerase epsilon:origin complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry542
component stoichiometry: Stoichiometry545
component: PhysicalEntity61
component: DNA polymerase epsilon (name copied from entity in Homo sapiens)
xref: UnificationXref1945
cellular location: GO:0005654
comment: Reactome DB_ID: 3639818

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: O97470
data source: Provenance1
name: ADP/ATP translocase 1
name: ADP,ATP carrier protein, heart/skeletal muscle isoform T1
name: SLC25A4
name: O97470
name: adenine nucleotide translocator 1
name: Adenine nucleotide translocator 1
name: ADP/ATP translocase 1 monomer
xref: UnificationXref7869
feature: FragmentFeature1610
cellular location: GO:0005743
comment: Reactome DB_ID: 3643622
display name: ANT 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54VB3
data source: Provenance1
name: COQ7_HUMAN
name: Q54VB3
name: Ubiquinone biosynthesis protein COQ7 homolog
xref: UnificationXref7831
feature: FragmentFeature1609
cellular location: GO:0005743
comment: Reactome DB_ID: 3650876
display name: COQ7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54VN2
data source: Provenance1
name: Q54VN2
name: COQ5_HUMAN
name: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial ecNumber2.1.1.201/ecNumber
xref: UnificationXref7824
feature: FragmentFeature1608
cellular location: GO:0005759
comment: Reactome DB_ID: 3650862
display name: COQ5

COQ3_HUMAN
type: Protein
entity reference: Q54XD0
data source: Provenance1
name: Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial ecNumber2.1.1.114/ecNumber
name: Note: the coordinates are copied over from Homo sapiens.
name: Q54XD0
name: COQ3(?-369)
xref: UnificationXref7814
feature: FragmentFeature1607
cellular location: GO:0005759
comment: Reactome DB_ID: 3650849
display name: COQ3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54EN1
data source: Provenance1
name: Ubiquinone biosynthesis monooxygenase COQ6 ecNumber1.14.13.-/ecNumber
name: COQ6_HUMAN
name: Q54EN1
xref: UnificationXref7802
feature: FragmentFeature1606
cellular location: GO:0005743
comment: Reactome DB_ID: 3650855
display name: COQ6

Para-hydroxybenzoate--polyprenyltransferase, mitochondrial
type: Protein
entity reference: Q54U71
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: COQ2_HUMAN
name: Q54U71
xref: UnificationXref7785
feature: FragmentFeature1605
cellular location: GO:0005743
comment: Reactome DB_ID: 3650868
display name: COQ2

DDK (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry525
component stoichiometry: Stoichiometry526
component: Protein626
component: PhysicalEntity64
xref: UnificationXref1921
cellular location: GO:0005654
comment: Reactome DB_ID: 3639839

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54VJ9
data source: Provenance1
name: Decaprenyl-diphosphate synthase subunit 2 ecNumber2.5.1.91/ecNumber
name: DLP1_HUMAN
name: Q54VJ9
xref: UnificationXref7774
feature: FragmentFeature1604
cellular location: GO:0005759
comment: Reactome DB_ID: 3650886
display name: PDSS2

Mcm10:active pre-replicative complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry531
component stoichiometry: Stoichiometry530
component: PhysicalEntity65
component: active pre-replicative complex (name copied from entity in Homo sapiens)
xref: UnificationXref1924
cellular location: GO:0005654
comment: Reactome DB_ID: 3639842

UniProt:Q9GTN7
type: ProteinReference
xref: UnificationXref840
organism: Dictyostelium discoideum

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54VJ9
data source: Provenance1
name: Decaprenyl-diphosphate synthase subunit 1 ecNumber2.5.1.91/ecNumber
name: DPS1_HUMAN
name: Q54VJ9
xref: UnificationXref7772
feature: FragmentFeature1603
cellular location: GO:0005759
comment: Reactome DB_ID: 3650884
display name: PDSS1

UnificationXref2369
type: UnificationXref
id: 196066
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=196066

active pre-replicative complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry529
component stoichiometry: Stoichiometry528
component: CDC6:ORC:origin complex (name copied from entity in Homo sapiens)
component: Mcm2-7 complex (name copied from entity in Homo sapiens)
xref: UnificationXref1922
cellular location: GO:0005654
comment: Reactome DB_ID: 3639841

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q55G11
data source: Provenance1
name: ASAH2(1-780)
name: Neutral ceramidase
name: Q55G11
name: ASAH2_HUMAN
xref: UnificationXref7756
feature: FragmentFeature1602
cellular location: GO:0005886
comment: Reactome DB_ID: 3649928
display name: ASAH2

UnificationXref2368
type: UnificationXref
id: CHEBI:63910
db: ChEBI

CDK (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry533
component stoichiometry: Stoichiometry534
component: PhysicalEntity66
component: Protein627
xref: UnificationXref1927
cellular location: GO:0005654
comment: Reactome DB_ID: 3639833

Q54BK2
type: Protein
entity reference: Q54BK2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: ASAH2(1-780)
name: Neutral ceramidase
name: ASAH2_HUMAN
xref: UnificationXref7754
feature: FragmentFeature1601
cellular location: GO:0005886
comment: Reactome DB_ID: 3649924
display name: ASAH2

UnificationXref2367
type: UnificationXref
id: REACT_4609
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4609.3

UnificationXref2366
type: UnificationXref
id: 29366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29366

CDT1:CDC6:ORC:origin complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry521
component stoichiometry: Stoichiometry522
component: PhysicalEntity63
component: CDC6:ORC:origin complex (name copied from entity in Homo sapiens)
xref: UnificationXref1910
cellular location: GO:0005654
comment: Reactome DB_ID: 3639767

UnificationXref2365
type: UnificationXref
id: CHEBI:18009
db: ChEBI

pre-replicative complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry524
component stoichiometry: Stoichiometry523
component: CDT1:CDC6:ORC:origin complex (name copied from entity in Homo sapiens)
component: Mcm2-7 complex (name copied from entity in Homo sapiens)
xref: UnificationXref1911
cellular location: GO:0005654
comment: Reactome DB_ID: 3639793

UnificationXref2364
type: UnificationXref
id: REACT_2991
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2991.3

CDK:DDK:Mcm10:pre-replicative complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry532
component stoichiometry: Stoichiometry535
component stoichiometry: Stoichiometry527
component: DDK (name copied from entity in Homo sapiens)
component: Mcm10:active pre-replicative complex (name copied from entity in Homo sapiens)
component: CDK (name copied from entity in Homo sapiens)
xref: UnificationXref1928
cellular location: GO:0005654
comment: Reactome DB_ID: 3639843

UnificationXref2350
type: UnificationXref
id: 3651877
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651877

UnificationXref2351
type: UnificationXref
id: REACT_103492
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103492.9

UnificationXref2352
type: UnificationXref
id: 3651874
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651874

Mcm2-7 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry520
component stoichiometry: Stoichiometry518
component stoichiometry: Stoichiometry515
component stoichiometry: Stoichiometry517
component stoichiometry: Stoichiometry516
component stoichiometry: Stoichiometry519
component: Protein620
component: Protein622
component: Protein624
component: Protein623
component: Protein621
component: Protein619
xref: UnificationXref1908
cellular location: GO:0005654
comment: Reactome DB_ID: 3639792

CDC6:ORC:origin complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry513
component stoichiometry: Stoichiometry514
component: ORC:origin (name copied from entity in Homo sapiens)
component: Protein618
xref: UnificationXref1891
cellular location: GO:0005654
comment: Reactome DB_ID: 3639764

Orc2 associated with MCM8 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry509
component stoichiometry: Stoichiometry508
component: Protein617
component: Protein613
xref: UnificationXref1883
cellular location: GO:0005654
comment: Reactome DB_ID: 3639762

ORC:origin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry511
component stoichiometry: Stoichiometry504
component stoichiometry: Stoichiometry505
component stoichiometry: Stoichiometry506
component stoichiometry: Stoichiometry512
component stoichiometry: Stoichiometry507
component stoichiometry: Stoichiometry510
component: Protein616
component: Protein614
component: PhysicalEntity62
component: Orc2 associated with MCM8 (name copied from entity in Homo sapiens)
component: PhysicalEntity61
component: Protein615
component: Protein612
xref: UnificationXref1884
cellular location: GO:0005654
comment: Reactome DB_ID: 3639763

UnificationXref4496
type: UnificationXref
id: REACT_90700
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90700.9

UnificationXref4497
type: UnificationXref
id: 3651704
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651704

UnificationXref4494
type: UnificationXref
id: REACT_94764
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94764.9

UnificationXref4495
type: UnificationXref
id: 3651705
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651705

UnificationXref4492
type: UnificationXref
id: REACT_77057
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77057.9

UnificationXref4493
type: UnificationXref
id: 3651706
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651706

UnificationXref4490
type: UnificationXref
id: REACT_4394
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4394.1

UnificationXref4491
type: UnificationXref
id: 3640098
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640098

Homologues of ASAH2(1-780)
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q54BK2
xref: UnificationXref7757
cellular location: GO:0005886
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3649929

SequenceSite2890
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/9331217
type: PublicationXref
id: 9331217
author: Cooper, JA
author: Hart, MC
author: Korshunova, YO
db: Pubmed
title: Vertebrates have conserved capping protein alpha isoforms with specific expression patterns
source: Cell Motil Cytoskeleton 38:120-32
year: 1997

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0232174
data source: Provenance1
name: DDB0232174
name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
name: ENPP7_HUMAN
xref: UnificationXref7745
feature: FragmentFeature1600
cellular location: GO:0005886
comment: Reactome DB_ID: 3649999
display name: ENPP7

SequenceSite2891
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite2892
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2893
type: SequenceSite
position status: EQUAL
sequence position: 512

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54C16
data source: Provenance1
name: Q54C16
name: ASM_HUMAN
name: Sphingomyelin phosphodiesterase
xref: UnificationXref7726
feature: FragmentFeature1597
cellular location: GO:0043202
comment: Reactome DB_ID: 3649912
display name: SMPD1

Homologues of SMPD1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7729
cellular location: GO:0043202
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3649917

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0184404
data source: Provenance1
name: GBA2_HUMAN
name: Non-lysosomal glucosylceramidase
name: DDB0184404
xref: UnificationXref7737
feature: FragmentFeature1599
cellular location: GO:0005886
comment: Reactome DB_ID: 3650576
display name: GBA2

UnificationXref4499
type: UnificationXref
id: 3651693
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651693

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q55C09
data source: Provenance1
name: Q55C09
name: ASM_HUMAN
name: Sphingomyelin phosphodiesterase
xref: UnificationXref7728
feature: FragmentFeature1598
cellular location: GO:0043202
comment: Reactome DB_ID: 3649916
display name: SMPD1

UnificationXref4498
type: UnificationXref
id: REACT_83610
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83610.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q55A00
data source: Provenance1
name: Q55A00
name: sphingosine-1-phosphate phosphatase 2
xref: UnificationXref7655
feature: FragmentFeature1594
cellular location: GO:0005789
comment: Reactome DB_ID: 3647174
display name: SGPP2

UnificationXref2358
type: UnificationXref
id: REACT_10604
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10604.2

Orc1:Orc4:Orc5:Orc3:Orc2:origin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry496
component stoichiometry: Stoichiometry495
component: Protein616
component: Orc4:Orc5:Orc3:Orc2:origin (name copied from entity in Homo sapiens)
xref: UnificationXref1874
cellular location: GO:0005654
comment: Reactome DB_ID: 3639750

SequenceSite2898
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q55A00
data source: Provenance1
name: sphingosine-1-phosphate phosphatase 1
name: Q55A00
xref: UnificationXref7654
feature: FragmentFeature1593
cellular location: GO:0005789
comment: Reactome DB_ID: 3647173
display name: SGPP1

UnificationXref2357
type: UnificationXref
id: 196095
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=196095

ORC complex bound to origin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry499
component stoichiometry: Stoichiometry497
component stoichiometry: Stoichiometry498
component stoichiometry: Stoichiometry502
component stoichiometry: Stoichiometry503
component stoichiometry: Stoichiometry501
component stoichiometry: Stoichiometry500
component: Protein616
component: Protein614
component: PhysicalEntity62
component: Protein613
component: PhysicalEntity61
component: Protein615
component: Protein612
xref: UnificationXref1880
cellular location: GO:0005654
comment: Reactome DB_ID: 3644250

SequenceSite2899
type: SequenceSite
position status: EQUAL
sequence position: 512

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0233869
data source: Provenance1
name: DDB0233869
name: AGAL_HUMAN
name: Alpha-galactosidase A
xref: UnificationXref7712
feature: FragmentFeature1596
cellular location: GO:0043202
comment: Reactome DB_ID: 3649905
display name: GLA

Orc5:Orc3:Orc2:origin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry492
component stoichiometry: Stoichiometry491
component: Protein614
component: Orc3:Orc2:origin (name copied from entity in Homo sapiens)
xref: UnificationXref1864
cellular location: GO:0005654
comment: Reactome DB_ID: 3639738

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54RV9
data source: Provenance1
name: PXLP-SGPL1
name: Q54RV9
name: sphingosine-1-phosphate lyase 1
xref: UnificationXref7663
feature: FragmentFeature1595
feature: ModificationFeature195
cellular location: GO:0005789
comment: Reactome DB_ID: 3647182
display name: SGPL1

UnificationXref2359
type: UnificationXref
id: CHEBI:15378
db: ChEBI

Orc4:Orc5:Orc3:Orc2:origin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry493
component stoichiometry: Stoichiometry494
component: Orc5:Orc3:Orc2:origin (name copied from entity in Homo sapiens)
component: Protein615
xref: UnificationXref1869
cellular location: GO:0005654
comment: Reactome DB_ID: 3639744

ChEBI:26125 phytosterols
type: SmallMoleculeReference
name: phytosterols
xref: UnificationXref2620

UnificationXref2354
type: UnificationXref
id: 3651762
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651762

Orc2:origin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry487
component stoichiometry: Stoichiometry488
component: Protein613
component: PhysicalEntity61
xref: UnificationXref1858
cellular location: GO:0005654
comment: Reactome DB_ID: 3639731

SequenceSite2894
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2353
type: UnificationXref
id: REACT_91535
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91535.9

Orc3:Orc2:origin (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry490
component stoichiometry: Stoichiometry489
component: Protein612
component: Orc2:origin (name copied from entity in Homo sapiens)
xref: UnificationXref1859
cellular location: GO:0005654
comment: Reactome DB_ID: 3639732

SequenceSite2895
type: SequenceSite
position status: EQUAL
sequence position: 512

UnificationXref2356
type: UnificationXref
id: CHEBI:17998
db: ChEBI

SequenceSite2896
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2355
type: UnificationXref
id: REACT_100847
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100847.9

SequenceSite2897
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite2884
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2883
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite2886
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2885
type: SequenceSite
position status: EQUAL
sequence position: 512

UniProt:Q55GJ7
type: ProteinReference
xref: UnificationXref10705
organism: Dictyostelium discoideum

SequenceSite2888
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2887
type: SequenceSite
position status: EQUAL
sequence position: 512

UniProt:Q55GJ6
type: ProteinReference
xref: UnificationXref772
organism: Dictyostelium discoideum

SequenceSite2889
type: SequenceSite
position status: EQUAL
sequence position: 512

UnificationXref4445
type: UnificationXref
id: 3643833
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643833

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q556M4
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: Q556M4
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7507
feature: FragmentFeature1549
cellular location: GO:0005789
comment: Reactome DB_ID: 3642611
display name: CYP1A2

UnificationXref4446
type: UnificationXref
id: REACT_34089
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34089.10

Q1ZXG3
type: Protein
entity reference: Q1ZXG3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P450-P3
name: Cytochrome P450 1A2
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7508
feature: FragmentFeature1550
cellular location: GO:0005789
comment: Reactome DB_ID: 3642615
display name: CYP1A2

UnificationXref4443
type: UnificationXref
id: 169509
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=169509

UniProt:Q55GJ2
type: ProteinReference
xref: UnificationXref13015
organism: Dictyostelium discoideum

Homologues of CYP1B1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q1ZXG3
member physical entity: Q54DT2
xref: UnificationXref7536
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3645622

UnificationXref4444
type: UnificationXref
id: REACT_7610
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7610.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXN4
data source: Provenance1
name: Q1ZXN4
name: Cytochrome P450 1B1
name: CP1B_HUMAN
xref: UnificationXref7510
feature: FragmentFeature1551
cellular location: GO:0005789
comment: Reactome DB_ID: 3645596
display name: CYP1B1

UnificationXref4449
type: UnificationXref
id: 3644242
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644242

SequenceSite2880
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54EM5
data source: Provenance1
name: Cytochrome P450 1B1
name: Q54EM5
name: CP1B_HUMAN
xref: UnificationXref7511
feature: FragmentFeature1552
cellular location: GO:0005789
comment: Reactome DB_ID: 3645597
display name: CYP1B1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q86A22
data source: Provenance1
name: Cytochrome P450 1B1
name: Q86A22
name: CP1B_HUMAN
xref: UnificationXref7512
feature: FragmentFeature1553
cellular location: GO:0005789
comment: Reactome DB_ID: 3645598
display name: CYP1B1

UnificationXref4447
type: UnificationXref
id: 3643831
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643831

SequenceSite2882
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q55AJ4
data source: Provenance1
name: Cytochrome P450 1B1
name: Q55AJ4
name: CP1B_HUMAN
xref: UnificationXref7513
feature: FragmentFeature1554
cellular location: GO:0005789
comment: Reactome DB_ID: 3645599
display name: CYP1B1

UnificationXref4448
type: UnificationXref
id: REACT_78771
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78771.9

SequenceSite2881
type: SequenceSite
position status: EQUAL
sequence position: 512

UnificationXref8477
type: UnificationXref
id: 110092
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110092

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54ZM4
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: Q54ZM4
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7504
feature: FragmentFeature1546
cellular location: GO:0005789
comment: Reactome DB_ID: 3642597
display name: CYP1A2

UnificationXref8476
type: UnificationXref
id: CHEBI:28862
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54Q53
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: Q54Q53
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7503
feature: FragmentFeature1545
cellular location: GO:0005789
comment: Reactome DB_ID: 3642593
display name: CYP1A2

UnificationXref8479
type: UnificationXref
id: 500077
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500077

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54D38
data source: Provenance1
name: Q54D38
name: P450-P3
name: Cytochrome P450 1A2
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7506
feature: FragmentFeature1548
cellular location: GO:0005789
comment: Reactome DB_ID: 3642605
display name: CYP1A2

UnificationXref8478
type: UnificationXref
id: REACT_4501
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4501.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54LT7
data source: Provenance1
name: Q54LT7
name: P450-P3
name: Cytochrome P450 1A2
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7505
feature: FragmentFeature1547
cellular location: GO:0005789
comment: Reactome DB_ID: 3642601
display name: CYP1A2

http://identifiers.org/pubmed/12920597
type: PublicationXref
id: 12920597
author: Hamm, LL
author: Nakhoul, NL
db: Pubmed
title: Non-erythroid Rh glycoproteins: a putative new family of mammalian ammonium transporters
source: Pflugers Arch 447:807-12
year: 2004

UnificationXref8473
type: UnificationXref
id: REACT_100354
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100354.9

UnificationXref4442
type: UnificationXref
id: REACT_7812
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7812.1

UnificationXref8472
type: UnificationXref
id: 3642839
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642839

UnificationXref4441
type: UnificationXref
id: 169515
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=169515

UnificationXref8475
type: UnificationXref
id: REACT_21986
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21986.1

UnificationXref4440
type: UnificationXref
id: REACT_104231
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104231.9

UnificationXref8474
type: UnificationXref
id: 500071
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500071

UnificationXref8471
type: UnificationXref
id: REACT_80989
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80989.9

UnificationXref8470
type: UnificationXref
id: 3642840
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642840

SequenceSite2875
type: SequenceSite
position status: EQUAL
sequence position: 512

http://identifiers.org/pubmed/17222083
type: PublicationXref
id: 17222083
author: Lamarche-Vane, N
author: Tcherkezian, J
db: Pubmed
title: Current knowledge of the large RhoGAP family of proteins
source: Biol Cell 99:67-86
year: 2007

SequenceSite2874
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2873
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite2872
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2879
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite2878
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2877
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite2876
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54CS3
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: Q54CS3
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7497
feature: FragmentFeature1539
cellular location: GO:0005789
comment: Reactome DB_ID: 3642567
display name: CYP1A2

UnificationXref4432
type: UnificationXref
id: 3640058
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640058

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXF3
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: CYPIA2
name: P(3)450
name: P450 4
name: Q1ZXF3
xref: UnificationXref7498
feature: FragmentFeature1540
cellular location: GO:0005789
comment: Reactome DB_ID: 3642571
display name: CYP1A2

UnificationXref4433
type: UnificationXref
id: REACT_82474
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82474.9

UnificationXref4434
type: UnificationXref
id: 3651701
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651701

UnificationXref4435
type: UnificationXref
id: REACT_96221
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96221.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXF5
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: CYPIA2
name: Q1ZXF5
name: P(3)450
name: P450 4
xref: UnificationXref7501
feature: FragmentFeature1543
cellular location: GO:0005789
comment: Reactome DB_ID: 3642585
display name: CYP1A2

UnificationXref4436
type: UnificationXref
id: 3640059
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640059

SequenceSite2871
type: SequenceSite
position status: EQUAL
sequence position: 512

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54SK0
data source: Provenance1
name: Q54SK0
name: P450-P3
name: Cytochrome P450 1A2
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7502
feature: FragmentFeature1544
cellular location: GO:0005789
comment: Reactome DB_ID: 3642589
display name: CYP1A2

UnificationXref4437
type: UnificationXref
id: 3640060
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640060

SequenceSite2870
type: SequenceSite
position status: EQUAL
sequence position: 1

Q54DT2
type: Protein
entity reference: Q54DT2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: P450-P3
name: Cytochrome P450 1A2
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7499
feature: FragmentFeature1541
cellular location: GO:0005789
comment: Reactome DB_ID: 3642575
display name: CYP1A2

UnificationXref4438
type: UnificationXref
id: REACT_102760
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102760.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXL7
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: CYPIA2
name: P(3)450
name: Q1ZXL7
name: P450 4
xref: UnificationXref7500
feature: FragmentFeature1542
cellular location: GO:0005789
comment: Reactome DB_ID: 3642581
display name: CYP1A2

UnificationXref4439
type: UnificationXref
id: 3651699
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651699

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q554S4
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: CYPIA2
name: P(3)450
name: Q554S4
name: P450 4
xref: UnificationXref7495
feature: FragmentFeature1537
cellular location: GO:0005789
comment: Reactome DB_ID: 3642559
display name: CYP1A2

UnificationXref8489
type: UnificationXref
id: REACT_3439
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3439.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54SV9
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: Q54SV9
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7494
feature: FragmentFeature1536
cellular location: GO:0005789
comment: Reactome DB_ID: 3642555
display name: CYP1A2

UnificationXref8488
type: UnificationXref
id: 109378
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109378

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q556M5
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: Q556M5
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7493
feature: FragmentFeature1535
cellular location: GO:0005789
comment: Reactome DB_ID: 3642551
display name: CYP1A2

UnificationXref8487
type: UnificationXref
id: CHEBI:15918
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54E98
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: CYPIA2
name: P(3)450
name: Q54E98
name: P450 4
xref: UnificationXref7492
feature: FragmentFeature1534
cellular location: GO:0005789
comment: Reactome DB_ID: 3642545
display name: CYP1A2

UnificationXref8486
type: UnificationXref
id: REACT_138749
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138749.5

UnificationXref8485
type: UnificationXref
id: 3642833
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642833

UnificationXref8484
type: UnificationXref
id: REACT_92049
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92049.9

UnificationXref4431
type: UnificationXref
id: 3640057
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640057

UnificationXref8483
type: UnificationXref
id: 3641979
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641979

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54QD2
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: Q54QD2
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7496
feature: FragmentFeature1538
cellular location: GO:0005789
comment: Reactome DB_ID: 3642563
display name: CYP1A2

UnificationXref4430
type: UnificationXref
id: 3640056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640056

http://identifiers.org/pubmed/8647866
type: PublicationXref
id: 8647866
author: Kozasa, T
author: Gilman, AG
db: Pubmed
title: Protein kinase C phosphorylates G12 alpha and inhibits its interaction with G beta gamma
source: J Biol Chem 271:12562-7
year: 1996

UnificationXref8482
type: UnificationXref
id: 3641977
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641977

UnificationXref8481
type: UnificationXref
id: Q54XF2
db: UniProt

UnificationXref8480
type: UnificationXref
id: REACT_22011
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22011.1

SequenceSite2869
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite2866
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2865
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite2868
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXL7
data source: Provenance1
name: Cytochrome P450 1B1
name: Q1ZXL7
name: CP1B_HUMAN
xref: UnificationXref7527
feature: FragmentFeature1568
cellular location: GO:0005789
comment: Reactome DB_ID: 3645613
display name: CYP1B1

SequenceSite2867
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite2862
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2861
type: SequenceSite
position status: EQUAL
sequence position: 698

SequenceSite2864
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2863
type: SequenceSite
position status: EQUAL
sequence position: 319

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54LT7
data source: Provenance1
name: Q54LT7
name: Cytochrome P450 1B1
name: CP1B_HUMAN
xref: UnificationXref7532
feature: FragmentFeature1573
cellular location: GO:0005789
comment: Reactome DB_ID: 3645618
display name: CYP1B1

UniProt:Q55GL2
type: ProteinReference
xref: UnificationXref12156
organism: Dictyostelium discoideum

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54D38
data source: Provenance1
name: Q54D38
name: Cytochrome P450 1B1
name: CP1B_HUMAN
xref: UnificationXref7533
feature: FragmentFeature1574
cellular location: GO:0005789
comment: Reactome DB_ID: 3645619
display name: CYP1B1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q556M4
data source: Provenance1
name: Cytochrome P450 1B1
name: Q556M4
name: CP1B_HUMAN
xref: UnificationXref7534
feature: FragmentFeature1575
cellular location: GO:0005789
comment: Reactome DB_ID: 3645620
display name: CYP1B1

UnificationXref4469
type: UnificationXref
id: 3640064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640064

SequenceSite2860
type: SequenceSite
position status: EQUAL
sequence position: 1

Q1ZXG3
type: Protein
entity reference: Q1ZXG3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cytochrome P450 1B1
name: CP1B_HUMAN
xref: UnificationXref7535
feature: FragmentFeature1576
cellular location: GO:0005789
comment: Reactome DB_ID: 3645621
display name: CYP1B1

Activation of NMDA receptor upon glutamate binding and postsynaptic events
type: Pathway
data source: Provenance1
pathway component: REACT 104029.9
evidence: Evidence392
xref: UnificationXref3661
xref: UnificationXref3660
pathway order: PathwayStep380
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXF5
data source: Provenance1
name: Cytochrome P450 1B1
name: Q1ZXF5
name: CP1B_HUMAN
xref: UnificationXref7528
feature: FragmentFeature1569
cellular location: GO:0005789
comment: Reactome DB_ID: 3645614
display name: CYP1B1

UnificationXref4467
type: UnificationXref
id: 3640068
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640068

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54SK0
data source: Provenance1
name: Q54SK0
name: Cytochrome P450 1B1
name: CP1B_HUMAN
xref: UnificationXref7529
feature: FragmentFeature1570
cellular location: GO:0005789
comment: Reactome DB_ID: 3645615
display name: CYP1B1

UnificationXref4468
type: UnificationXref
id: Q54ST4
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54Q53
data source: Provenance1
name: Cytochrome P450 1B1
name: Q54Q53
name: CP1B_HUMAN
xref: UnificationXref7530
feature: FragmentFeature1571
cellular location: GO:0005789
comment: Reactome DB_ID: 3645616
display name: CYP1B1

UnificationXref4465
type: UnificationXref
id: 3640076
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640076

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54ZM4
data source: Provenance1
name: Cytochrome P450 1B1
name: Q54ZM4
name: CP1B_HUMAN
xref: UnificationXref7531
feature: FragmentFeature1572
cellular location: GO:0005789
comment: Reactome DB_ID: 3645617
display name: CYP1B1

UnificationXref4466
type: UnificationXref
id: Q54MD4
db: UniProt

UnificationXref8495
type: UnificationXref
id: CHEBI:17239
db: ChEBI

UnificationXref4464
type: UnificationXref
id: Q54E21
db: UniProt

UnificationXref8494
type: UnificationXref
id: REACT_4046
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4046.2

UnificationXref4463
type: UnificationXref
id: 3640080
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640080

UnificationXref8497
type: UnificationXref
id: REACT_2815
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2815.2

UnificationXref4462
type: UnificationXref
id: Q54MH9
db: UniProt

UnificationXref8496
type: UnificationXref
id: 110094
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110094

UnificationXref4461
type: UnificationXref
id: REACT_89073
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89073.9

UnificationXref8499
type: UnificationXref
id: 110096
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110096

Q54DT2
type: Protein
entity reference: Q54DT2
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Cytochrome P450 1B1
name: CP1B_HUMAN
xref: UnificationXref7526
feature: FragmentFeature1567
cellular location: GO:0005789
comment: Reactome DB_ID: 3645612
display name: CYP1B1

UnificationXref4460
type: UnificationXref
id: 3652006
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652006

UnificationXref8498
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXF3
data source: Provenance1
name: Cytochrome P450 1B1
name: CP1B_HUMAN
name: Q1ZXF3
xref: UnificationXref7525
feature: FragmentFeature1566
cellular location: GO:0005789
comment: Reactome DB_ID: 3645611
display name: CYP1B1

http://identifiers.org/pubmed/15665109
type: PublicationXref
id: 15665109
author: Dirago, L
author: Mifsud, S
author: Hyland, C
author: Alexander, WS
author: Hilton, DJ
author: Carpinelli, MR
author: Nicola, NA
author: Metcalf, D
db: Pubmed
title: Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene
source: Blood 105:3480-7
year: 2005

UnificationXref8491
type: UnificationXref
id: REACT_21486
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21486.1

SequenceSite2858
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8490
type: UnificationXref
id: 500009
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500009

SequenceSite2859
type: SequenceSite
position status: EQUAL
sequence position: 698

UnificationXref8493
type: UnificationXref
id: 110091
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110091

UnificationXref8492
type: UnificationXref
id: CHEBI:28846
db: ChEBI

SequenceSite2857
type: SequenceSite
position status: EQUAL
sequence position: 2261

SequenceSite2856
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2855
type: SequenceSite
position status: EQUAL
sequence position: 2261

SequenceSite2854
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2853
type: SequenceSite
position status: EQUAL
sequence position: 2261

SequenceSite2852
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2851
type: SequenceSite
position status: EQUAL
sequence position: 2261

SequenceSite2850
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54QD2
data source: Provenance1
name: Cytochrome P450 1B1
name: Q54QD2
name: CP1B_HUMAN
xref: UnificationXref7523
feature: FragmentFeature1564
cellular location: GO:0005789
comment: Reactome DB_ID: 3645609
display name: CYP1B1

UnificationXref4458
type: UnificationXref
id: 3644249
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644249

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54CS3
data source: Provenance1
name: Cytochrome P450 1B1
name: Q54CS3
name: CP1B_HUMAN
xref: UnificationXref7524
feature: FragmentFeature1565
cellular location: GO:0005789
comment: Reactome DB_ID: 3645610
display name: CYP1B1

UnificationXref4459
type: UnificationXref
id: REACT_92828
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92828.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54SV9
data source: Provenance1
name: Cytochrome P450 1B1
name: Q54SV9
name: CP1B_HUMAN
xref: UnificationXref7521
feature: FragmentFeature1562
cellular location: GO:0005789
comment: Reactome DB_ID: 3645607
display name: CYP1B1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q554S4
data source: Provenance1
name: Cytochrome P450 1B1
name: Q554S4
name: CP1B_HUMAN
xref: UnificationXref7522
feature: FragmentFeature1563
cellular location: GO:0005789
comment: Reactome DB_ID: 3645608
display name: CYP1B1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54E98
data source: Provenance1
name: Cytochrome P450 1B1
name: Q54E98
name: CP1B_HUMAN
xref: UnificationXref7519
feature: FragmentFeature1560
cellular location: GO:0005789
comment: Reactome DB_ID: 3645605
display name: CYP1B1

UnificationXref4454
type: UnificationXref
id: Q54BL9
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q556M5
data source: Provenance1
name: Cytochrome P450 1B1
name: Q556M5
name: CP1B_HUMAN
xref: UnificationXref7520
feature: FragmentFeature1561
cellular location: GO:0005789
comment: Reactome DB_ID: 3645606
display name: CYP1B1

UnificationXref4455
type: UnificationXref
id: 3644241
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644241

UniProt:Q55GM6
type: ProteinReference
xref: UnificationXref13374
organism: Dictyostelium discoideum

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXA4
data source: Provenance1
name: Cytochrome P450 1B1
name: Q1ZXA4
name: CP1B_HUMAN
xref: UnificationXref7517
feature: FragmentFeature1558
cellular location: GO:0005789
comment: Reactome DB_ID: 3645603
display name: CYP1B1

UnificationXref4456
type: UnificationXref
id: 3644247
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644247

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXL2
data source: Provenance1
name: Cytochrome P450 1B1
name: Q1ZXL2
name: CP1B_HUMAN
xref: UnificationXref7518
feature: FragmentFeature1559
cellular location: GO:0005789
comment: Reactome DB_ID: 3645604
display name: CYP1B1

UnificationXref4457
type: UnificationXref
id: 3644248
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644248

UnificationXref4451
type: UnificationXref
id: 3644237
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644237

UnificationXref4450
type: UnificationXref
id: Q54HR6
db: UniProt

UnificationXref4453
type: UnificationXref
id: 3644246
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3644246

UnificationXref4452
type: UnificationXref
id: Q55EA2
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXA1
data source: Provenance1
name: Cytochrome P450 1B1
name: Q1ZXA1
name: CP1B_HUMAN
xref: UnificationXref7516
feature: FragmentFeature1557
cellular location: GO:0005789
comment: Reactome DB_ID: 3645602
display name: CYP1B1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54QD0
data source: Provenance1
name: Cytochrome P450 1B1
name: Q54QD0
name: CP1B_HUMAN
xref: UnificationXref7515
feature: FragmentFeature1556
cellular location: GO:0005789
comment: Reactome DB_ID: 3645601
display name: CYP1B1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54NY3
data source: Provenance1
name: Cytochrome P450 1B1
name: Q54NY3
name: CP1B_HUMAN
xref: UnificationXref7514
feature: FragmentFeature1555
cellular location: GO:0005789
comment: Reactome DB_ID: 3645600
display name: CYP1B1

SequenceSite2849
type: SequenceSite
position status: EQUAL
sequence position: 2261

SequenceSite2847
type: SequenceSite
position status: EQUAL
sequence position: 727

SequenceSite2848
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref4402
type: UnificationXref
id: 3651692
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651692

UnificationXref4401
type: UnificationXref
id: REACT_28865
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28865.10

UnificationXref4400
type: UnificationXref
id: 3640048
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640048

UnificationXref8437
type: UnificationXref
id: 3641829
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641829

UnificationXref4406
type: UnificationXref
id: 3639866
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639866

UnificationXref8436
type: UnificationXref
id: 3641828
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641828

UnificationXref4405
type: UnificationXref
id: 3639849
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639849

UnificationXref8439
type: UnificationXref
id: REACT_84781
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_84781.9

UnificationXref4404
type: UnificationXref
id: 3639850
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639850

UnificationXref8438
type: UnificationXref
id: 3641831
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641831

UnificationXref4403
type: UnificationXref
id: REACT_80370
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80370.9

UnificationXref4409
type: UnificationXref
id: 3639874
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639874

SequenceSite2840
type: SequenceSite
position status: EQUAL
sequence position: 38

Netrin-1 signaling
type: Pathway
data source: Provenance1
pathway component: REACT 113542.8
evidence: Evidence178
xref: UnificationXref1658
xref: UnificationXref1657
pathway order: PathwayStep172
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref4408
type: UnificationXref
id: 3639870
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639870

SequenceSite2841
type: SequenceSite
position status: EQUAL
sequence position: 508

UnificationXref4407
type: UnificationXref
id: REACT_154162
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154162.3

SequenceSite2842
type: SequenceSite
position status: EQUAL
sequence position: 28

SequenceSite2843
type: SequenceSite
position status: EQUAL
sequence position: 325

SequenceSite2844
type: SequenceSite
position status: EQUAL
sequence position: 40

SequenceSite2845
type: SequenceSite
position status: EQUAL
sequence position: 520

SequenceSite2846
type: SequenceSite
position status: EQUAL
sequence position: 43

SequenceSite2837
type: SequenceSite
position status: EQUAL
sequence position: 427

SequenceSite2836
type: SequenceSite
position status: EQUAL
sequence position: 35

SequenceSite2839
type: SequenceSite
position status: EQUAL
sequence position: 508

SequenceSite2838
type: SequenceSite
position status: EQUAL
sequence position: 38

UnificationXref8432
type: UnificationXref
id: CHEBI:18261
db: ChEBI

http://identifiers.org/pubmed/224930
type: PublicationXref
id: 224930
author: Inoue, K
author: Yamasawa, K
author: Nishimukai, H
db: Pubmed
title: Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes.
source: Biochim Biophys Acta 569:117-23
year: 1979

UnificationXref8433
type: UnificationXref
id: 73588
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73588

UnificationXref8434
type: UnificationXref
id: REACT_4649
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4649.2

UnificationXref8435
type: UnificationXref
id: Q55DL0
db: UniProt

http://identifiers.org/pubmed/18436705
type: PublicationXref
id: 18436705
author: Scheuner, D
author: Kaufman, RJ
db: Pubmed
title: The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes
source: Endocr Rev 29:317-33
year: 2008

UnificationXref8430
type: UnificationXref
id: 3641824
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641824

UnificationXref8431
type: UnificationXref
id: REACT_102683
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102683.9

http://identifiers.org/pubmed/22108505
type: PublicationXref
id: 22108505
author: Basler, Konrad
author: Herr, Patrick
db: Pubmed
title: Porcupine-mediated lipidation is required for Wnt recognition by Wls
source: Dev. Biol. 361:392-402
year: 2012

UnificationXref8449
type: UnificationXref
id: 73541
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73541

http://identifiers.org/pubmed/18614053
type: PublicationXref
id: 18614053
author: Jung, Sung Yun
author: Kim, Seong-Tae
author: Jia, Junling
author: Yang, Tao
author: Shi, Xiaomin
author: Zhang, Pumin
author: Huang, Zhiwei
author: Qin, J
author: Li, Yehua
author: Zhang, Jinglan
author: Fu, Xiaoyong
author: Wang, Y
author: Pan, Xuewen
author: Kim, Beom-Jun
db: Pubmed
title: Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast
source: Mol. Cell 31:143-51
year: 2008

UnificationXref8448
type: UnificationXref
id: CHEBI:27468
db: ChEBI

UnificationXref8447
type: UnificationXref
id: REACT_101466
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_101466.9

SequenceSite2830
type: SequenceSite
position status: EQUAL
sequence position: 37

UniProt:Q55GG6
type: ProteinReference
xref: UnificationXref4039
organism: Dictyostelium discoideum

SequenceSite2831
type: SequenceSite
position status: EQUAL
sequence position: 176

UniProt:Q55GG8
type: ProteinReference
xref: UnificationXref1971
organism: Dictyostelium discoideum

SequenceSite2834
type: SequenceSite
position status: EQUAL
sequence position: 66

SequenceSite2835
type: SequenceSite
position status: EQUAL
sequence position: 418

Toll Like Receptor 4 (TLR4) Cascade
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction69
evidence: Evidence110
xref: UnificationXref1150
xref: RelationshipXref74
xref: UnificationXref1151
pathway order: PathwayStep105
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

SequenceSite2832
type: SequenceSite
position status: EQUAL
sequence position: 33

SequenceSite2833
type: SequenceSite
position status: EQUAL
sequence position: 750

SequenceSite2828
type: SequenceSite
position status: EQUAL
sequence position: 53

SequenceSite2827
type: SequenceSite
position status: EQUAL
sequence position: 694

SequenceSite2826
type: SequenceSite
position status: EQUAL
sequence position: 539

SequenceSite2825
type: SequenceSite
position status: EQUAL
sequence position: 29

SequenceSite2829
type: SequenceSite
position status: EQUAL
sequence position: 728

UnificationXref8445
type: UnificationXref
id: 3641836
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641836

UnificationXref8446
type: UnificationXref
id: 3641838
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641838

UnificationXref8443
type: UnificationXref
id: Q964D8
db: UniProt

UnificationXref8444
type: UnificationXref
id: 3641835
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641835

UnificationXref8441
type: UnificationXref
id: 73590
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73590

UnificationXref8442
type: UnificationXref
id: REACT_3353
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3353.2

UnificationXref8440
type: UnificationXref
id: CHEBI:16958
db: ChEBI

UnificationXref8459
type: UnificationXref
id: 73619
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73619

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXA1
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: Q1ZXA1
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7489
feature: FragmentFeature1531
cellular location: GO:0005789
comment: Reactome DB_ID: 3642533
display name: CYP1A2

UnificationXref4428
type: UnificationXref
id: 3640055
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640055

UnificationXref8458
type: UnificationXref
id: CHEBI:16320
db: ChEBI

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54QD0
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: Q54QD0
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7488
feature: FragmentFeature1530
cellular location: GO:0005789
comment: Reactome DB_ID: 3642529
display name: CYP1A2

UnificationXref4427
type: UnificationXref
id: 3640054
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640054

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXL2
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: Q1ZXL2
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7491
feature: FragmentFeature1533
cellular location: GO:0005789
comment: Reactome DB_ID: 3642541
display name: CYP1A2

UnificationXref4426
type: UnificationXref
id: REACT_156440
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156440.3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXA4
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: CYPIA2
name: Q1ZXA4
name: P(3)450
name: P450 4
xref: UnificationXref7490
feature: FragmentFeature1532
cellular location: GO:0005789
comment: Reactome DB_ID: 3642537
display name: CYP1A2

UnificationXref4425
type: UnificationXref
id: 3640052
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640052

UnificationXref4424
type: UnificationXref
id: REACT_28463
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28463.10

UnificationXref4423
type: UnificationXref
id: 3651698
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651698

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54NY3
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: Q54NY3
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7487
feature: FragmentFeature1529
cellular location: GO:0005789
comment: Reactome DB_ID: 3642525
display name: CYP1A2

UnificationXref4422
type: UnificationXref
id: REACT_28448
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28448.10

UnificationXref4421
type: UnificationXref
id: 3640045
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640045

SequenceSite2821
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2822
type: SequenceSite
position status: EQUAL
sequence position: 2458

SequenceSite2823
type: SequenceSite
position status: EQUAL
sequence position: 28

SequenceSite2824
type: SequenceSite
position status: EQUAL
sequence position: 290

UniProt:Q55GH9
type: ProteinReference
xref: UnificationXref10967
organism: Dictyostelium discoideum

UnificationXref4429
type: UnificationXref
id: REACT_29349
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29349.10

SequenceSite2820
type: SequenceSite
position status: EQUAL
sequence position: 79

SequenceSite2819
type: SequenceSite
position status: EQUAL
sequence position: 2458

SequenceSite2818
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2815
type: SequenceSite
position status: EQUAL
sequence position: 896

SequenceSite2814
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2817
type: SequenceSite
position status: EQUAL
sequence position: 488

SequenceSite2816
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8450
type: UnificationXref
id: REACT_2862
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2862.1

UnificationXref8451
type: UnificationXref
id: 3641853
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641853

UnificationXref4420
type: UnificationXref
id: REACT_91935
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91935.9

UnificationXref8452
type: UnificationXref
id: REACT_95628
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95628.9

UnificationXref8453
type: UnificationXref
id: CHEBI:1670
db: ChEBI

UnificationXref8454
type: UnificationXref
id: 73617
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73617

IRS-related events triggered by IGF1R
type: Pathway
data source: Provenance1
pathway component: REACT 110584.9
evidence: Evidence1642
xref: UnificationXref11302
xref: UnificationXref11301
pathway order: PathwayStep1551
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref8455
type: UnificationXref
id: REACT_3591
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3591.3

UnificationXref8456
type: UnificationXref
id: 3641854
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641854

UnificationXref8457
type: UnificationXref
id: REACT_146496
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146496.5

UnificationXref4415
type: UnificationXref
id: 3639883
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639883

UnificationXref4414
type: UnificationXref
id: 3639882
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639882

UnificationXref4417
type: UnificationXref
id: 3639890
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639890

http://identifiers.org/pubmed/22983114
type: PublicationXref
id: 22983114
author: Boutros, Michael
author: Bartscherer, Kerstin
author: Chaudhary, Varun
author: Gross, Julia Christina
db: Pubmed
title: Active Wnt proteins are secreted on exosomes
source: Nat. Cell Biol. 14:1036-45
year: 2012

UnificationXref8469
type: UnificationXref
id: 3642837
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642837

UnificationXref4416
type: UnificationXref
id: REACT_85240
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85240.9

UnificationXref4411
type: UnificationXref
id: 3639879
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639879

http://identifiers.org/pubmed/7217086
type: PublicationXref
id: 7217086
author: Ortiz, de Montellano PR
author: Beilan, HS
author: Mico, BA
author: Kunze, KL
db: Pubmed
title: Destruction of cytochrome P-450 by ethylene. Structure of the resulting prosthetic heme adduct.
source: J Biol Chem 256:4395-9
year: 1981

UnificationXref4410
type: UnificationXref
id: 3639878
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639878

UnificationXref4413
type: UnificationXref
id: 3639881
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639881

UnificationXref4412
type: UnificationXref
id: 3639880
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639880

UniProt:Q55GI5
type: ProteinReference
xref: UnificationXref8069
organism: Dictyostelium discoideum

SequenceSite2812
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2813
type: SequenceSite
position status: EQUAL
sequence position: 890

SequenceSite2810
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2811
type: SequenceSite
position status: EQUAL
sequence position: 434

UnificationXref4419
type: UnificationXref
id: 3639892
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639892

UnificationXref4418
type: UnificationXref
id: 3639891
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3639891

SequenceSite2809
type: SequenceSite
position status: EQUAL
sequence position: 414

SequenceSite2808
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2807
type: SequenceSite
position status: EQUAL
sequence position: 364

SequenceSite2806
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8460
type: UnificationXref
id: REACT_4433
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4433.4

SequenceSite2805
type: SequenceSite
position status: EQUAL
sequence position: 378

SequenceSite2804
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2803
type: SequenceSite
position status: EQUAL
sequence position: 376

Sphingolipid de novo biosynthesis
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction672
pathway component: BiochemicalReaction681
pathway component: BiochemicalReaction677
pathway component: BiochemicalReaction678
pathway component: BiochemicalReaction674
pathway component: BiochemicalReaction680
pathway component: BiochemicalReaction679
pathway component: BiochemicalReaction683
pathway component: BiochemicalReaction673
pathway component: BiochemicalReaction675
pathway component: BiochemicalReaction682
pathway component: BiochemicalReaction676
evidence: Evidence1084
xref: RelationshipXref805
xref: UnificationXref7684
xref: UnificationXref7683
pathway order: PathwayStep1060
pathway order: PathwayStep1056
pathway order: PathwayStep1057
pathway order: PathwayStep1059
pathway order: PathwayStep1055
pathway order: PathwayStep1063
pathway order: PathwayStep1064
pathway order: PathwayStep1061
pathway order: PathwayStep1062
pathway order: PathwayStep1065
pathway order: PathwayStep1054
pathway order: PathwayStep1058
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref8463
type: UnificationXref
id: 3651775
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651775

UnificationXref8464
type: UnificationXref
id: REACT_107691
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107691.9

http://identifiers.org/pubmed/6693436
type: PublicationXref
id: 6693436
author: Hu, SZ
author: Wang, TS
author: Korn, D
db: Pubmed
title: DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha.
source: J Biol Chem 259:1854-65
year: 1984

UnificationXref8461
type: UnificationXref
id: 3641855
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641855

UnificationXref8462
type: UnificationXref
id: REACT_127881
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127881.5

Transport of inorganic cations/anions and amino acids/oligopeptides
type: Pathway
data source: Provenance1
pathway component: Amino acid transport across the plasma membrane
pathway component: REACT 152931.3
pathway component: REACT 82709.9
evidence: Evidence301
xref: UnificationXref2880
xref: UnificationXref2879
xref: RelationshipXref178
pathway order: PathwayStep288
pathway order: PathwayStep285
pathway order: PathwayStep290
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref8467
type: UnificationXref
id: GO:0005758
db: GENE ONTOLOGY

UnificationXref8468
type: UnificationXref
id: Q54QJ9
db: UniProt

UnificationXref8465
type: UnificationXref
id: 3651773
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651773

UnificationXref8466
type: UnificationXref
id: REACT_105430
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105430.9

Evidence1123
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11698644
xref: http://identifiers.org/pubmed/15118080
xref: http://identifiers.org/pubmed/12110366
xref: http://identifiers.org/pubmed/15664996
xref: http://identifiers.org/pubmed/15496471
comment: ChREBP (Carbohydrate Response Element Binding Protein) is a large multidomain protein containing a nuclear localization signal near its amino terminus, polyproline domains, a basic helix-loop-helix-leucine zipper domain, and a leucine-zipper-like domain (Uyeda et al., 2002). Its dephosphorylation in response to molecular signals associated with the well-fed state allows it to enter the nucleus, interact with MLX protein, and bind to ChRE DNA sequence motifs near Acetyl-CoA carboxylase, Fatty acid synthase, and Pyruvate kinase (L isoform) genes (Ishi et al.2004). This sequence of events is outlined schematically in the picture below (adapted from Kawaguchi et al. (2001) - copyright (2001) National Academy of Sciences, U.S.A.).

Evidence1122
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the end of this reaction, 1 molecule of '1-acyl-sn-glycerol-3-phosphate acyltransferase alpha ' is present. This reaction takes place in the 'nucleus'.

Evidence1121
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the end of this reaction, 1 molecule of 'Acetyl-CoA carboxylase 2 ' is present. This reaction takes place in the 'nucleus'.

Evidence1120
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: At the end of this reaction, 1 molecule of 'citrate lyase monomer' is present. This reaction takes place in the 'nucleus'.

Disease
type: Pathway
data source: Provenance1
pathway component: REACT 149205.4
pathway component: REACT 138274.5
pathway component: REACT 80808.9
pathway component: REACT 131207.5
pathway component: REACT 130674.5
pathway component: REACT 118090.7
pathway component: REACT 149035.4
pathway component: REACT 161864.2
pathway component: REACT 141635.5
evidence: Evidence1718
xref: UnificationXref11712
xref: UnificationXref11713
pathway order: PathwayStep1643
pathway order: PathwayStep1644
pathway order: PathwayStep1675
pathway order: PathwayStep1646
pathway order: PathwayStep1656
pathway order: PathwayStep1688
pathway order: PathwayStep1671
pathway order: PathwayStep1659
pathway order: PathwayStep1686
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

http://identifiers.org/pubmed/12800216
type: PublicationXref
id: 12800216
author: Zhang, M
author: Zhu, F
db: Pubmed
title: DNA polymerase zeta: new insight into eukaryotic mutagenesis and mammalian embryonic development.
source: World J Gastroenterol 9:1165-9
year: 2003

UnificationXref8543
type: UnificationXref
id: 3640911
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640911

UnificationXref6750
type: UnificationXref
id: REACT_122495
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122495.1

UniProt:Q55G45
type: ProteinReference
xref: UnificationXref11039
organism: Dictyostelium discoideum

UnificationXref8542
type: UnificationXref
id: 3640909
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640909

UnificationXref8545
type: UnificationXref
id: 3642953
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642953

Evidence1129
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19666465
comment: In the second salvage step, dihydrofolate reductase (DHFR) can regenerate BH4 from BH2, a process which increases the BH4:BH2 ratio providing BH4 for coupled eNOS production of NO. In mice cell lines, DHFR inhibition or knockdown diminishes the BH4:BH2 ratio and exacerbates eNOS uncoupling (Crabtree et al. 2009).

UnificationXref6752
type: UnificationXref
id: 428686
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428686

UnificationXref8544
type: UnificationXref
id: REACT_34766
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34766.10

Evidence1128
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18511317
comment: In the first of two salvage steps to maintain BH4 levels in the cell, sepiapterin is taken up by the cell and reduced by sepiapterin reductase (SRP) to form BH2 (Sawabe et al. 2008).

UnificationXref6751
type: UnificationXref
id: CHEBI:17553
db: ChEBI

Evidence1127
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1883349
comment: Sepiapterin reductase (SPR) (Ichinose et al. 1991) reduces DHNTP to tetrahydrobiopterin (BH4).

Evidence1126
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3536512
xref: http://identifiers.org/pubmed/8137809
xref: http://identifiers.org/pubmed/8307017
xref: http://identifiers.org/pubmed/7563095
xref: http://identifiers.org/pubmed/10531334
comment: 6-pyruvoyl tetrahydrobiopterin synthase (PTPS) (Takikawa et al. 1986) catalyses the second step in BH4 biosynthesis, the dephosphorylation of DHNTP to 6-pyruvoyl-tetrahydropterin (PTHP). PTPS is believed to function as a homohexamer (Nar et al. 1994, Bürgisser et al. 1994) and has a requirement for Zn2+ (one Zn2+ ion bound per subunit) and Mg2+ ions for activity (Bürgisser et al. 1995). The phosphorylation of Ser-19 is an essential modification for enzyme activity (Scherer-Oppliger et al. 1999).

http://identifiers.org/pubmed/11851336
type: PublicationXref
id: 11851336
author: Swain, A
author: Dunten, P
author: Crowther, R
author: Kammlott, U
author: Wertheimer, SJ
author: Michel, H
author: Weber, D
author: Ramsey, GB
author: Levin, W
author: Belunis, C
author: Hollfelder, K
db: Pubmed
title: Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site
source: J Mol Biol 316:257-264
year: 2002

UniProt:Q55FS0
type: ProteinReference
xref: UnificationXref9026
organism: Dictyostelium discoideum

UnificationXref8541
type: UnificationXref
id: 3640908
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3640908

Evidence1125
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7663943
xref: http://identifiers.org/pubmed/8068008
comment: The first and rate-limiting enzyme in tetrahydrobiopterin de novo biosynthesis is GTP cyclohydrolase I (GCH1, GTPCHI). Three different isoforms are produced but only isoform 1 is functionally active (Gütlich et al. 1994). GCH1 is functional as a homodecamer. First, a monomer of GCH1 forms a dimer. Then five dimers arrange into a ring-like structure to form the homodecamer (Nar et al. 1995).

http://identifiers.org/pubmed/1270801
type: PublicationXref
id: 1270801
author: Franklin, EC
author: Rosenthal, CJ
author: Greenspan, J
author: Frangione, B
db: Pubmed
title: Isolation and partial characterization of SAA-an amyloid-related protein from human serum
source: J Immunol 116:1415-8
year: 1976

UnificationXref8540
type: UnificationXref
id: Q8T137
db: UniProt

Evidence1124
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12721358
xref: http://identifiers.org/pubmed/15509864
xref: http://identifiers.org/pubmed/12684532
xref: http://identifiers.org/pubmed/12626323
comment: Many hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insulin mediates the storage of excess nutrients, glucagon is involved in the mobilization of energy resources in response to low blood glucose levels, principally by stimulating hepatic glucose output. Small doses of glucagon are sufficient to induce significant glucose elevations. These hormone-driven regulatory pathways enable the body to sense and respond to changed amounts of nutrients in the blood and demands for energy. Glucagon and Insulin act through various metabolites and enzymes that target specific steps in metabolic pathways for sugar and fatty acids. The processes responsible for the long-term control of fat synthesis and short term control of glycolysis by key metabolic products and enzymes are annotated in this module as six specific pathways: Pathway 1. Glucagon signalling in metabolic pathways: In response to low blood glucose, pancreatic alpha-cells release glucagon. The binding of glucagon to its receptor results in increased cAMP synthesis, and Protein Kinase A (PKA) activation. Pathway 2. PKA mediated phosphorylation:PKA phosphorylates key enzymes, e.g., 6-Phosphofructo-2-kinase /Fructose-2,6-bisphosphatase (PF2K-Pase) at serine 36, and regulatory proteins, e.g., Carbohydrate Response Element Binding Protein (ChREBP) at serine 196 and threonine 666. Insulin mediated responses to high blood glucose will be annotated in future versions of Reactome. In brief, the binding of insulin to its receptor leads to increased protein phosphatase activity and to hydrolysis of cAMP by cAMP phosphodiesterase. These events counteract the regulatory effects of glucagon. Pathway 3: Insulin stimulates increased synthesis of Xylulose-5-phosphate (Xy-5-P). Activation of the insulin receptor results indirectly in increased Xy-5-P synthesis from Glyceraldehyde-3-phosphate and …

UnificationXref4610
type: UnificationXref
id: REACT_154405
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154405.3

UnificationXref6757
type: UnificationXref
id: 3649851
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649851

UnificationXref4611
type: UnificationXref
id: 3643903
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643903

UnificationXref6758
type: UnificationXref
id: 3649852
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649852

UnificationXref6759
type: UnificationXref
id: 3649853
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649853

UnificationXref8546
type: UnificationXref
id: 3642956
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642956

UnificationXref4614
type: UnificationXref
id: 3643920
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643920

UnificationXref6753
type: UnificationXref
id: REACT_20211
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20211.2

UnificationXref8547
type: UnificationXref
id: 3642959
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642959

UnificationXref4615
type: UnificationXref
id: REACT_95049
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95049.9

UnificationXref6754
type: UnificationXref
id: Q554D8
db: UniProt

UnificationXref8548
type: UnificationXref
id: 3642960
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642960

UnificationXref4612
type: UnificationXref
id: REACT_156107
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156107.3

UnificationXref6755
type: UnificationXref
id: 3649847
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649847

UnificationXref8549
type: UnificationXref
id: 3642962
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642962

UnificationXref4613
type: UnificationXref
id: 3643919
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643919

UnificationXref6756
type: UnificationXref
id: Q869T9
db: UniProt

UnificationXref4618
type: UnificationXref
id: 170150
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=170150

http://identifiers.org/pubmed/10222061
type: PublicationXref
id: 10222061
author: Meller, N
author: Isakov, N
author: Elitzur, Y
db: Pubmed
title: Protein kinase C-theta (PKCtheta) distribution analysis in hematopoietic cells: proliferating T cells exhibit high proportions of PKCtheta in the particulate fraction
source: Cell Immunol 193:185-93
year: 1999

UnificationXref4619
type: UnificationXref
id: REACT_6526
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_6526.1

UnificationXref4616
type: UnificationXref
id: 3643909
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643909

http://identifiers.org/pubmed/2408761
type: PublicationXref
id: 2408761
author: Sharp, PA
author: Moore, CL
db: Pubmed
title: Accurate cleavage and polyadenylation of exogenous RNA substrate.
source: Cell 41:845-55
year: 1985

UnificationXref4617
type: UnificationXref
id: REACT_154562
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154562.3

Evidence1132
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17237348
comment: Nitric oxide (NO), a multifunctional second messenger, is implicated in physiological functions in mammals that range from immune response and potentiation of synaptic transmission to dilation of blood vessels and muscle relaxation. NO is a highly active molecule that diffuses across cell membranes and cannot be stored inside the producing cell. Its signaling capacity must be controlled at the levels of biosynthesis and local availability. Indeed, NO production by NO synthases is under complex and tight control, being regulated at transcriptional and translational levels, through co- and posttranslational modifications, and by subcellular localization. NO is synthesized from L-arginine by a family of nitric oxide synthases (NOS). Three NOS isoforms have been characterized: neuronal NOS (nNOS, NOS1) primarily found in neuronal tissue and skeletal muscle; inducible NOS (iNOS, NOS2) originally isolated from macrophages and later discovered in many other cells types; and endothelial NOS (eNOS, NOS3) present in vascular endothelial cells, cardiac myocytes, and in blood platelets. The enzymatic activity of all three isoforms is dependent on calmodulin, which binds to nNOS and eNOS at elevated intracellular calcium levels, while it is tightly associated with iNOS even at basal calcium levels. As a result, the enzymatic activity of nNOS and eNOS is modulated by changes in intracellular calcium levels, leading to transient NO production, while iNOS continuously releases NO independent of fluctuations in intracellular calcium levels and is mainly regulated at the gene expression level (Pacher et al. 2007). The NOS enzymes share a common basic structural organization and requirement for substrate cofactors for enzymatic activity. A central calmodulin-binding motif separates an oxygenase (NH2-terminal) domain from a reductase (COOH-terminal) domain. Binding sites for cofactors NADPH, FAD, and FMN are located within the reductase domain, while binding sites for tetrahydrobiopter…

Evidence1131
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16722822
xref: http://identifiers.org/pubmed/12842859
comment: Originally identified as endothelium-derived relaxing factor, eNOS derived NO is a critical signaling molecule in vascular homeostasis. It regulates blood pressure and vascular tone, and is involved in vascular smooth muscle cell proliferation, platelet aggregation, and leukocyte adhesion. Loss of the bioavailability of endothelium derived NO is a key feature of endothelial dysfunction and is implicated in the pathogenesis of cardiovascular disease such as hypertension and atherosclerosis. The endothelial isoform eNOS is unique among the nitric oxide synthase (NOS) family in that it is co-translationally modified at its amino terminus by myristoylation and is further acylated by palmitoylation (two residues next to the myristoylation site). These modifications target eNOS to the plasma membrane caveolae and lipid rafts. eNOS activation and subsequent nitric oxide (NO) production is stimulated by a variety of stimuli, such as fluid shear stress generated by blood flow, vascular endothelial growth factor (VEGF), bradykinin, estrogen, insulin, and angiopoietin. The activity of eNOS is further regulated by numerous post-translational modifications, including protein-protein interactions, phosphorylation, and subcellular localization. Following activation, eNOS shuttles between caveolae and other subcellular compartments such as the noncaveolar plasma membrane portions, Golgi apparatus, and perinuclear structures. This subcellular distribution is variable depending upon cell type and mode of activation. Subcellular localization of eNOS has a profound effect on its ability to produce NO as the availability of its substrates and cofactors will vary with location. eNOS is primarily particulate, and depending on the cell type, eNOS can be found in several membrane compartments: plasma membrane caveolae, lipid rafts, and intracellular membranes such as the Golgi complex. In addition, it has been reported that eNOS can also be detected in the nucleus, however, the conditions a…

Evidence1134
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7273846
xref: http://identifiers.org/pubmed/2188967
comment: Pyruvate sits at an intersection of key pathways of energy metabolism. It is the end product of glycolysis and the starting point for gluconeogenesis, and can be generated by transamination of alanine. It can be converted by the pyruvate dehydrogenase complex to acetyl CoA (Reed and Hackert 1990) which can enter the TCA cycle or serve as the starting point for the syntheses of long chain fatty acids, steroids, and ketone bodies depending on the tissue and metabolic state in which it is formed. It also plays a central role in balancing the energy needs of various tissues in the body. Under conditions in which oxygen supply is limiting, e.g., in exercising muscle, or in the absence of mitochondria, e.g., in red blood cells, re-oxidation of NADH produced by glycolysis cannot be coupled to generation of ATP. Instead, re-oxidation is coupled to the reduction of pyruvate to lactate. This lactate is released into the blood, and is taken up primarily by the liver, where it is oxidized to pyruvate and can be used for gluconeogenesis (Cori 1981).

Evidence1133
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16049940
xref: http://identifiers.org/pubmed/15138885
xref: http://identifiers.org/pubmed/15946682
xref: http://identifiers.org/pubmed/10679936
xref: http://identifiers.org/pubmed/2188967
xref: http://identifiers.org/pubmed/11752427
comment: The mitochondrial pyruvate dehydrogenase complex catalyzes the reaction of pyruvate, CoASH, and NAD+ to form acetylCoA, CO2, and NADH. The enzyme complex contains multiple copies of three different proteins, E1 alpha, E1 beta, E2, and E3, each with distinct catalytic activities (Reed and Hackert 1990; Zhou et al 2001). The reaction starts with the oxidative decarboxylation of pyruvate catalyzed by E1 alpha and beta (pyruvate dehydrogenase). Lipoamide cofactor associated with E1 is reduced at the same time. Next, the acetyl group derived from pyruvate is transferred to coenzyme A in two steps catalyzed by E2 (dihydrolipolyl transacetylase). Finally, the oxidized form of lipoamide is regenerated and electrons are transferred to NAD+ in two steps catalyzed by E3 (dihydrolipoyl dehydrogenase). The biochemical details of this reaction have been worked out with pyruvate dehydrogenase complex and subunits purified from bovine tissue and other non-human sources. Direct evidence for the roles of the corresponding human proteins comes from studies of patients expressing mutant forms of E1 alpha (Lissens et al. 2000), E1 beta (Brown et al. 2004), E2 (Head et al. 2005), and E3 (Brautigam et al. 2005).

Evidence1130
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18321209
xref: http://identifiers.org/pubmed/21550412
xref: http://identifiers.org/pubmed/17555404
xref: http://identifiers.org/pubmed/10727395
comment: Tetrahydrobiopterin (BH4) is an essential co-factor for the aromatic amino acid hydroxylases and glycerol ether monooxygenase and it regulates nitric oxide synthase (NOS) activity. Inherited BH4 deficiency leads to hyperphenylalaninemia, and dopamine and neurotransmitter deficiency in the brain. BH4 maintains enzymatic coupling to L-arginine oxidation to produce NO. Oxidation of BH4 to BH2 results in NOS uncoupling, resulting in superoxide (O2.-) formation rather than NO. Superoxide rapidly reacts with NO to produce peroxynitrite which can further uncouple NOS. These reactive oxygen species (superoxide and peroxynitrite) can contribute to increased oxidative stress in the endothelium leading to atherosclerosis and hypertension (Thöny et al. 2000, Crabtree & Channon 2011, Schulz et al. 2008, Schmidt & Alp 2007). The synthesis, recycling and effects of BH4 are shown here. Three enzymes are required for the de novo biosynthesis of BH4 and two enzymes for the recycling of BH4.

UnificationXref8534
type: UnificationXref
id: 3648025
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648025

UnificationXref6763
type: UnificationXref
id: 3649858
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649858

UnificationXref8533
type: UnificationXref
id: 3648024
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648024

Evidence1139
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2005110
xref: http://identifiers.org/pubmed/10673423
comment: NNT (nicotinamide nucleotide transhydrogenase) associated with the inner mitochondrial membrane catalyzes the reaction of mitochondrial NADPH and NAD+ to form NADP+ and NADH. The reaction is coupled to the translocation of a proton across the inner mitochondrial membrane into the mitochondrial matrix (White et al, 2000). The active form of NNT is inferred to be a homodimer based on the known structure of its bovine homolog (Yamaguchi and Hatefi 1991).

UnificationXref6762
type: UnificationXref
id: 3649856
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649856

UnificationXref8532
type: UnificationXref
id: REACT_78357
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78357.9

UnificationXref6761
type: UnificationXref
id: 3649855
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649855

UnificationXref8531
type: UnificationXref
id: 3641899
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641899

UnificationXref6760
type: UnificationXref
id: 3649854
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649854

UnificationXref8530
type: UnificationXref
id: 3641897
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641897

Evidence1136
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1052766
xref: http://identifiers.org/pubmed/1946331
comment: Mitochondrial aconitase reversibly converts citrate to isocitrate via a cis-aconitate intermediate. Mitochondrial aconitase activity has been demonstrated in diverse human tissue extracts (Slaughter et al. 1975) and a protein homologous to the well-characterized porcine enzyme has been purified from human tissues (Baldwin et al. 1991).

Evidence1135
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9792662
xref: http://identifiers.org/pubmed/9809442
comment: Mitochondrial citrate synthase dimer catalyzes the irreversible reaction of acetyl-CoA, water, and oxaloacetate to form citrate and coenzyme A. This reaction is the entry point of two-carbon units into the citric acid cycle. The reaction is subject to allosteric regulation. The gene encoding the human enzyme has been cloned (Goldenthal et al. 1998), but the enzyme has not been characterized in detail - its properties are inferred from those of the well-studied homologous pig enzyme (e.g., Morgunov and Srere 1998).

Evidence1138
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16737955
xref: http://identifiers.org/pubmed/14555658
xref: http://identifiers.org/pubmed/17432878
xref: http://identifiers.org/pubmed/20435888
comment: Mitochondrial isocitrate dehydrogenase IDH3 catalyzes the irreversible reaction of isocitrate and NAD+ to form alpha ketoglutarate, CO2, and NADH + H+. The enzyme is a heteromer containing four polypeptide chains, two IDH3A, one IDH3B, and one IDH3G, and two Mn++ (Dange and Colman 2010). It is activated by ADP (Soundar et al. 2003, 2006; Bzymek and Colman 2007). This is the first of four oxidation reactions in the citric acid cycle, and the first decarboxylation.

Evidence1137
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1052766
xref: http://identifiers.org/pubmed/1946331
comment: Mitochondrial aconitase reversibly converts isocitrate to citrate via a cis-aconitate intermediate. Mitochondrial aconitase activity has been demonstrated in diverse human tissue extracts (Slaughter et al. 1975) and a protein homologous to the well-characterized porcine enzyme has been purified from human tissues (Baldwin et al. 1991).

UnificationXref4620
type: UnificationXref
id: 182620
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=182620

http://identifiers.org/pubmed/7681363
type: PublicationXref
id: 7681363
author: Tang, Z
author: Coleman, TR
db: Pubmed
title: Negative regulation of the wee1 protein kinase by direct action of the nim1/cdr1 mitotic inducer
source: Cell 72:919-29
year: 1993

UnificationXref8539
type: UnificationXref
id: REACT_3495
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3495.2

UnificationXref4621
type: UnificationXref
id: REACT_8297
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_8297.1

UnificationXref6768
type: UnificationXref
id: 1500603
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500603

UnificationXref4622
type: UnificationXref
id: 3643912
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643912

UnificationXref6769
type: UnificationXref
id: REACT_124825
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124825.1

UnificationXref8537
type: UnificationXref
id: CHEBI:17858
db: ChEBI

UnificationXref4623
type: UnificationXref
id: 3643914
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643914

UnificationXref6766
type: UnificationXref
id: REACT_5335
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5335.1

UnificationXref8538
type: UnificationXref
id: 111745
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111745

UnificationXref4624
type: UnificationXref
id: REACT_86196
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86196.9

UnificationXref6767
type: UnificationXref
id: CHEBI:16732
db: ChEBI

Glucose transport
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction175
pathway component: BiochemicalReaction174
pathway component: BiochemicalReaction176
pathway component: BiochemicalReaction173
evidence: Evidence308
xref: RelationshipXref186
xref: UnificationXref2941
xref: UnificationXref2940
pathway order: PathwayStep295
pathway order: PathwayStep297
pathway order: PathwayStep296
pathway order: PathwayStep294
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref8535
type: UnificationXref
id: 3648027
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3648027

UnificationXref4625
type: UnificationXref
id: 3652007
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652007

UnificationXref6764
type: UnificationXref
id: REACT_144351
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144351.5

UniProt:Q55FR9
type: ProteinReference
xref: UnificationXref84
organism: Dictyostelium discoideum

UnificationXref8536
type: UnificationXref
id: REACT_85039
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85039.9

UnificationXref4626
type: UnificationXref
id: REACT_145425
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145425.5

UnificationXref6765
type: UnificationXref
id: 110614
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110614

UnificationXref4627
type: UnificationXref
id: 3643923
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643923

UnificationXref4628
type: UnificationXref
id: 3643924
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643924

UnificationXref4629
type: UnificationXref
id: 3643925
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643925

ChEBI:28477 7alpha,12alpha-dihydroxycholest-4-en-3-one
type: SmallMoleculeReference
name: 7alpha,12alpha-dihydroxycholest-4-en-3-one
xref: UnificationXref6584

SequenceSite2901
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite2900
type: SequenceSite
position status: EQUAL
sequence position: 1

UniProt:P20054
type: ProteinReference
xref: UnificationXref8342
organism: Dictyostelium discoideum

SequenceSite2906
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2907
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite2908
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2909
type: SequenceSite
position status: EQUAL
sequence position: 512

Evidence1101
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10777520
comment: Mitochondrial COQ3 is an O-methyltransferase required in the reaction to convert 3-demethylubiquinol-10 (DeMQ10H2) to ubiquinol-10 (Q10H2) (Jonassen & Clarke 2000).

SequenceSite2902
type: SequenceSite
position status: EQUAL
sequence position: 1

Evidence1100
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10501970
xref: http://identifiers.org/pubmed/8621692
xref: http://identifiers.org/pubmed/16624818
comment: Ubiquinone biosynthesis protein COQ7 homolog (COQ7) (Vajo et al. 1999) catalyses the hydroxylation of 6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol (DMQ10H2) to 3-demethylubiquinol-10 (DeMQ10H2). This reaction is inferred from the equivalent reaction in yeast (Marbois & Clarke 1996, Tran et al. 2006).

SequenceSite2903
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite2904
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2905
type: SequenceSite
position status: EQUAL
sequence position: 512

UniProt:Q55FQ0
type: ProteinReference
xref: UnificationXref2243
organism: Dictyostelium discoideum

Evidence1105
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12161432
xref: http://identifiers.org/pubmed/11588141
comment: Acetylcholine released by parasympathetic nerve endings in the pancreas causes a potentiation of insulin release when glucose is present at concentrations greater than about 7 mM. Acetylcholine binds the Muscarinic Acetylcholine Receptor M3 on pancreatic beta cells. The binding has two effects: an increase in permeability of the cell to Na+ ions through an unknown mechanism, and the activation of Phospholipase C beta-1 through a heterotrimeric G protein, G(q). After acetylcholine binds the Muscarinic Acetycholine Receptor M3, the receptor activates the G protein Gq by causing the alpha subunit of Gq to exchange GDP for GTP. Activation of Gq in turn activates Phospholipase C beta-1. Phospholipase C beta-1 hydrolyzes the phosphodiester bond at the third position of phosphoinositol 4,5-bisphosphate, producing diacylglycerols (DAG) and inositol 1,4,5-trisphosphate. DAG remains in the cell membrane and causes Protein Kinase C alpha (PKC alpha) to translocate from the cytosol to the membrane. This results in the activation of PKC alpha which then phosphorylates target proteins on serine and threonine residues. One known target of PKC alpha is Myristoylated Alanine-rich C Kinase Substrate (MARCKS), which is believed to affect vesicle transport and may be responsible for the increased traffic of insulin granules seen in response to acetylcholine. Inositol trisphophate binds a receptor, the IP3 receptor, on calcium stores in the cell (probably the endoplasmic reticulum). The release of calcium into the cytosol stimulates the exocytosis of insulin granules.

Evidence1104
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11588141
comment: Diacylglycerol, produced by PLC beta-mediated PIP2 hydrolysis in G alpha (q) signalling, remains in the plasma membrane and binds Protein Kinase C alpha (PKC-alpha), causing PKC-alpha to translocate from the cytosol to the plasma membrane. PKC-alpha is thereby activated and phosphorylates target proteins.

Evidence1103
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Lipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphingolipids, eicosanoids, cholesterol, bile salts, steroid hormones, and fat-soluble vitamins. They function as a major source of energy (fatty acids, triacylglycerols, and ketone bodies), are major constituents of cell membranes (cholesterol and phospholipids), play a major role in their own digestion and uptake (bile salts), and participate in numerous signaling and regulatory processes (steroid hormones, eicosanoids, phosphatidylinositols, and sphingolipids). Because of their poor solubility in water, most lipids in extracellular spaces in the human body are found as complexes with specific carrier proteins. Regulation of the formation and movement of these lipoprotein complexes is a critical aspect of human lipid metabolism, and lipoprotein abnormalities are associated with major human disease processes including atherosclerosis and diabetes. The central steroid in human biology is cholesterol, obtained from animal fats consumed in the diet or synthesized de novo from acetyl-coenzyme A. (Vegetable fats contain various sterols but no cholesterol.) Cholesterol is an essential constituent of lipid bilayer membranes and is the starting point for the biosyntheses of bile acids and salts, steroid hormones, and vitamin D. Bile acids and salts are mostly synthesized in the liver. They are released into the intestine and function as detergents to solubilize dietary fats. Steroid hormones are mostly synthesized in the adrenal gland and gonads. They regulate energy metabolism and stress responses (glucocorticoids), salt balance (mineralocorticoids), and sexual development and function (androgens and estrogens). At the same time, chronically elevated cholesterol levels in the body are associated with the formation of atherosclerotic lesions and hence increased risk of heart attack…

Evidence1102
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/19531029
xref: http://identifiers.org/pubmed/17482885
xref: http://identifiers.org/pubmed/11051212
xref: PublicationXref2019
comment: The length of the polyisoprenoid chain of ubiquinone aka coenzyme Q (Q), varies depending on the species involved: it is 6 in budding yeast, Saccharomyces cerevisiae, (Q6) and 10 in humans (Q10). Most ubiquinone is naturally reduced to ubiquinol (Q10H2 in humans) and it is this form which dominates in most human tissues. It functions as an ubiquitous coenzyme in redox reactions and its ability both to associate with complexes I and III of the electron transport chain and to move freely in the inner mitochondrial membrane are central to its role in electron transport. In eukaryotes ubiquinones/ubiquinols are also found in other membranes such as the endoplasmic reticulum, Golgi vesicles, lysosomes and peroxisomes. Ubiquinol/ubiquinone is synthesized in the following way. Initially, the polyisoprenoid tail is assembled by a polyprenyl diphosphate synthase. Next, 4 hydroxybenzoate polyprenyltransferase (COQ2) catalyses the formation of the covalent linkage between the benzoquinone head group and the tail to produce 4 hydroxy 3 polyprenyl benzoic acid intermediate (DHB, 3 decaprenyl 4 hydroxybenzoic acid in humans). There follows modifications of the aromatic ring starting with hydroxylation, followed by O methylation, and decarboxylation to form the 2 methoxy 6 polyprenyl phenol intermediate (DMPhOH ; 2 methoxy 6 decaprenylphenol in humans). Following this, two additional methylations, one C methylation, and one O methylation step, finally generate the fully substituted hydroquinone, ubiquinol (Szkopinska 2000, Kagan & Quinn 2000, Tran & Clarke 2007, Kawamukai 2009).

UnificationXref8521
type: UnificationXref
id: Q54GN2
db: UniProt

Evidence1109
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12475787
xref: http://identifiers.org/pubmed/11815463
xref: http://identifiers.org/pubmed/8830891
xref: http://identifiers.org/pubmed/15569269
xref: http://identifiers.org/pubmed/17306374
xref: http://identifiers.org/pubmed/17900700
xref: http://identifiers.org/pubmed/11078440
xref: http://identifiers.org/pubmed/9914469
comment: Glucagon-like Peptide-1 (GLP-1) is secreted by L-cells in the intestine in response to glucose and fatty acids. GLP-1 circulates to the beta cells of the pancreas where it binds a G-protein coupled receptor, GLP-1R, on the plasma membrane. The binding activates the heterotrimeric G-protein G(s), causing the alpha subunit of G(s) to exchange GDP for GTP and dissociate from the beta and gamma subunits. The activated G(s) alpha subunit interacts with Adenylyl Cyclase VIII (Adenylate Cyclase VIII, AC VIII) and activates AC VIII to produce cyclic AMP (cAMP). cAMP then has two effects: 1) cAMP activates Protein Kinase A (PKA), and 2) cAMP activates Epac1 and Epac2, two guanyl nucleotide exchange factors. Binding of cAMP to PKA causes the catalytic subunits of PKA to dissociate from the regulatory subunits and become an active kinase. PKA is known to enhance insulin secretion by closing ATP-sensitive potassium channels, closing voltage-gated potassium channels, releasing calcium from the endoplasmic reticulum, and affecting insulin secretory granules. The exact mechanisms for PKA's action are not fully known. After prolonged increases in cAMP, PKA translocates to the nucleus where it regulates the PDX-1 and CREB transcription factors, activating transcription of the insulin gene. cAMP produced by AC VIII also activates Epac1 and Epac2, which catalyze the exchange of GTP for GDP on G-proteins, notably Rap1A.. Rap1A regulates insulin secretory granules and is believed to activate the Raf/MEK/ERK mitogenic pathway leading to proliferation of beta cells. The Epac proteins also interact with RYR calcium channels on the endoplasmic reticulum, the SUR1 subunits of ATP-sensitive potassium channels, and the Piccolo:Rim2 calcium sensor at the plasma membrane.

UnificationXref8520
type: UnificationXref
id: REACT_21449
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21449.1

Evidence1108
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15995848
xref: http://identifiers.org/pubmed/15569269
xref: http://identifiers.org/pubmed/17306374
xref: http://identifiers.org/pubmed/16973695
comment: Epac1 and Epac2 are activated by binding cAMP and positively regulate the exchange of GDP for GTP by the small GTPase Rap1A. The downstream effects of Rap1A:GTP in beta cells are uncertain but may involve increasing the number of "restless newcomer" secretory granules near the plasma membrane and thereby increasing secretion of insulin. Other effects of Rap1A :GTP may include regulating beta cell proliferation through activation of the Raf/MEK/ERK mitogenic cascade and activation of the PI3 Kinase/PDK/PKC cell growth pathway.

UnificationXref8523
type: UnificationXref
id: 3641867
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641867

Evidence1107
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11071853
xref: http://identifiers.org/pubmed/12401793
xref: http://identifiers.org/pubmed/18202100
xref: http://identifiers.org/pubmed/12496249
xref: http://identifiers.org/pubmed/15569269
xref: http://identifiers.org/pubmed/17306374
xref: http://identifiers.org/pubmed/16613879
xref: http://identifiers.org/pubmed/16973695
comment: Each molecule of Epac2 binds 2 molecules of cAMP. Epac2 binds cAMP less tightly than PKA binds cAMP so it is believed that Epac2 binds cAMP after PKA is saturated. The binding of cAMP by Epac2 activates the guanyl nucleotide exchange activity of Epac2. Epac2 has also been shown to directly bind the SUR1 subunits of ATP-gated potassium channels (KATP channels) in beta cells so Epac2 may regulate potassium transport. Epac2 interacts with the calcium sensor Piccolo in a complex with Rim2 at the cell membrane. This may influence exocytosis of insulin. Epac2 also interacts with the ryanodine-sensitive calcium channel on the ER membrane and may cause release of calcium from the ER into the cytosol.

UnificationXref6730
type: UnificationXref
id: REACT_129658
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129658.5

UnificationXref8522
type: UnificationXref
id: 3641866
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641866

Evidence1106
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11071853
xref: http://identifiers.org/pubmed/12401793
xref: http://identifiers.org/pubmed/18202100
xref: http://identifiers.org/pubmed/12496249
xref: http://identifiers.org/pubmed/15569269
xref: http://identifiers.org/pubmed/17306374
xref: http://identifiers.org/pubmed/16613879
xref: http://identifiers.org/pubmed/16973695
comment: Each molecule of Epac1 binds 1 molecule of cAMP. Epac1 binds cAMP less tightly than PKA binds cAMP so it is believed that Epac1 binds cAMP after PKA is saturated. The binding of cAMP by Epac1 activates the guanyl nucleotide exchange activity of Epac1. Epac1 has also been shown to bind the SUR1 subunit of ATP-gated potassium channels (KATP channels) in beta cells so Epac1 may participate in direct regulation of potassium transport. Epac1 also interacts with the calcium sensor Piccolo in a complex with Rim2 at the cell membrane. This may influence exocytosis of insulin.

UnificationXref8524
type: UnificationXref
id: 3641869
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641869

UnificationXref6731
type: UnificationXref
id: 3651856
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651856

UnificationXref8525
type: UnificationXref
id: REACT_102869
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102869.9

UnificationXref6732
type: UnificationXref
id: REACT_90572
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90572.9

UnificationXref8526
type: UnificationXref
id: 3642352
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642352

UnificationXref6733
type: UnificationXref
id: 1500594
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500594

UnificationXref8527
type: UnificationXref
id: REACT_147383
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147383.5

UnificationXref6734
type: UnificationXref
id: REACT_125604
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125604.1

http://identifiers.org/pubmed/19783045
type: PublicationXref
id: 19783045
author: Kongsuphol, Patthara
author: Kunzelmann, Karl
author: Schreiber, Rainer
author: Warth, R
author: Tian, Yuemin
author: Ousingsawat, Jiraporn
author: Aldehni, Fadi
db: Pubmed
title: Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions
source: Cell Calcium 46:233-41
year: 2009

UnificationXref8528
type: UnificationXref
id: Q54V77
db: UniProt

UnificationXref6735
type: UnificationXref
id: 3649691
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649691

UnificationXref8529
type: UnificationXref
id: 3641896
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641896

UnificationXref6736
type: UnificationXref
id: REACT_107469
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107469.9

UniProt:Q55FQ9
type: ProteinReference
xref: UnificationXref909
organism: Dictyostelium discoideum

UnificationXref6737
type: UnificationXref
id: 1498728
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1498728

UnificationXref6738
type: UnificationXref
id: REACT_124200
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124200.1

SequenceSite2910
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref6739
type: UnificationXref
id: CHEBI:35366
db: ChEBI

SequenceSite2912
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/3893466
type: PublicationXref
id: 3893466
author: Jornvall, H
db: Pubmed
title: Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes
source: Alcohol 2:61-6
year: 1985

SequenceSite2911
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite2919
type: SequenceSite
position status: EQUAL
sequence position: 247

SequenceSite2917
type: SequenceSite
position status: EQUAL
sequence position: 279

SequenceSite2918
type: SequenceSite
position status: EQUAL
sequence position: 1

Evidence1110
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7929812
xref: http://identifiers.org/pubmed/8027028
xref: http://identifiers.org/pubmed/8457197
xref: http://identifiers.org/pubmed/11780755
xref: http://identifiers.org/pubmed/7593639
xref: http://identifiers.org/pubmed/17380317
xref: http://identifiers.org/pubmed/9751501
xref: http://identifiers.org/pubmed/8987985
xref: http://identifiers.org/pubmed/7589840
comment: Human pancreatic beta cells express glucose transporters 1 and (GLUT1, GLUT2), which are responsible for uptake of glucose from the extracellular medium into the cytosol. (Rodent pancreatic beta cells express only Glut2.)

SequenceSite2915
type: SequenceSite
position status: EQUAL
sequence position: 512

SequenceSite2916
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/7890667
type: PublicationXref
id: 7890667
author: Liu, SM
author: Cheng, HF
author: Wong, LP
author: King, K
author: Jiang, MJ
author: Chen, CL
author: Lomasney, JW
db: Pubmed
title: Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis
source: J Biol Chem 270:5495-505
year: 1995

Evidence1112
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16321791
xref: http://identifiers.org/pubmed/11815463
xref: http://identifiers.org/pubmed/16556766
xref: http://identifiers.org/pubmed/18200017
xref: http://identifiers.org/pubmed/11078440
comment: Pancreatic beta cells integrate signals from several metabolites and hormones to control the secretion of insulin. In general, glucose triggers insulin secretion while other factors can amplify or inhibit the amount of insulin secreted in response to glucose. Factors which increase insulin secretion include the incretin hormones Glucose-dependent insulinotropic polypeptide (GIP and glucagon-like peptide-1 (GLP-1), acetylcholine, and fatty acids. Factors which inhibit insulin secretion include adrenaline and noradrenaline. Increased blood glucose levels from dietary carbohydrate play a dominant role in insulin release from the beta cells of the pancreas. Glucose catabolism in the beta cell is the transducer that links increased glucose levels to insulin release. Glucose uptake and glycolysis generate cytosolic pyruvate; pyruvate is transported to mitochondria and converted both to oxaloacetate which increases levels of TCA cycle intermediates, and to acetyl-CoA which is oxidized to CO2 via the TCA cycle. The rates of ATP synthesis and transport to the cytosol increase, plasma membrane ATP-sensitive inward rectifying potassium channels (KATP channels) close, the membrane depolarizes, and voltage-gated calcium channels in the membrane open (Muoio and Newgard 2008; Wiederkehr and Wollheim 2006). Elevated calcium concentrations near the plasma membrane cause insulin secretion in two phases: an initial high rate within minutes of glucose stimulation and a slow, sustained release lasting longer than 30 minutes. In the initial phase, 50-100 insulin granules already docked at the membrane are exocytosed. Exocytosis is rendered calcium-dependent by Synaptotagmin V/IX, a calcium-binding membrane protein located in the membrane of the docked granule, although the exact action of Synapototagmin in response to calcium is unknown. Calcium also causes a translocation of reserve granules within the cell towards the plasma membrane for release in the second, sustained phase of secret…

SequenceSite2913
type: SequenceSite
position status: EQUAL
sequence position: 512

Evidence1111
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2648994
xref: http://identifiers.org/pubmed/9587671
xref: http://identifiers.org/pubmed/5857365
xref: http://identifiers.org/pubmed/5840415
comment: A family of antiport, ATP-ADP translocases, preferentially export ATP from the matrix while importing ADP from the cytosol, thereby maintaining a high ADP:ATP ratio in the matrix. When there are increased energy demands on the body, such as under heavy exercise, cytosolic ADP rises and is exchanged with mitochondrial matrix ATP via the transmembrane ADP:ATP translocase. Increased ADP causes the proton-motive force to be discharged and protons enter via ATPase, thereby regenerating the ATP pool. There are 3 isoforms of translocases in humans; isoform 1 is the heart/skeletal muscle form, isoform 2 is the fibroblast form and isoform 3 is the liver form. All isoforms exist as homodimers. The translocase can adopt 2 different conformations, called the CATR (carboxyatractyloside) and BA (bongkrekic acid) conformations. Amongst the endogenous nucleotides, only ADP and ATP can trigger the rapid conversion between the CATR and BA conformations. The reaction can be summed as below: ADPout + ATPin <-> ADPin + ATPout

SequenceSite2914
type: SequenceSite
position status: EQUAL
sequence position: 1

Evidence1114
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12626323
comment: Glucagon and insulin are peptide hormones released from the pancreas into the blood, that normally act in complementary fashion to stabilize blood glucose concentration. When blood glucose levels rise, insulin release stimulates glucose uptake from the blood, glucose breakdown (glycolysis), and glucose storage as glycogen. When blood glucose levels fall, glucagon release stimulates glycogen breakdown and de novo glucose synthesis (gluconeogenesis), while inhibiting glycolysis and glycogen synthesis. At a molecular level, the binding of glucagon to the extracellular face of its receptor causes conformational changes in the receptor that allow the dissociation and activation of subunits Gs and Gq. The activation of Gq leads to the activation of phospholipase C, production of inositol 1,4,5-triphosphate, and subsequent release of intracellular calcium. The activation of Gs leads to activation of adenylate cyclase, an increase in intracellular cAMP levels, and activation of protein kinase A (PKA). Active PKA phosphorylates key enzymes of glycogenolysis, glycogenesis, gluconeogenesis, and glycolysis, modifying their activities. These signal transduction events, and some of their downstream consequences, are illustrated below (adapted from Jiang and Zhang, 2003).

Evidence1113
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Adenylate cyclase catalyses the synthesis of cyclic AMP (cAMP) from ATP. In the absence of cAMP, protein kinase A (PKA) exists as inactive tetramers of two catalytic subunits and two regulatory subunits. cAMP binding to PKA tetramers causes them to dissociate and release their catalytic subunits as active monomers. Four isoforms of the regulatory subunit are known, that differ in their tissue specificity and functional characteristics, but the specific isoform activated in response to glucagon signaling has not yet been identified.

Evidence1116
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12721358
xref: http://identifiers.org/pubmed/12110366
xref: http://identifiers.org/pubmed/12684532
comment: Xylulose-5-phosphate binds to Protein phosphatase 2A (PP2A), activating it. This regulatory step may be the crucial physiological link explaining the coordinately increased rates of glycolysis and lipogenesis generally observed in individuals consuming high-carbohydrate diets.

Evidence1115
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3539386
xref: http://identifiers.org/pubmed/12110366
xref: PublicationXref2055
comment: One of the downstream effects of insulin, mediated via protein phosphatase 2A (PP2A), is increased synthesis of Fructose-2,6-bisphosphate, an allosteric activator of phosphofructokinase 1 (PFK1). PFK1 in turn catalyzes the committed step of glycolysis so the net effect of this whole sequence of events set off by insulin is to increase cytosolic concentrations of the small molecules formed in the course of glycolysis. This in turn drives the increased synthesis of Xylulose-5-phosphate, itself a positive regulator of PP2A.

UniProt:Q55FP1
type: ProteinReference
xref: UnificationXref1996
organism: Dictyostelium discoideum

UniProt:Q55G11
type: ProteinReference
xref: UnificationXref7755
organism: Dictyostelium discoideum

UnificationXref8512
type: UnificationXref
id: REACT_21666
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21666.1

Evidence1118
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15509864
comment: LKB1 phosphorylates threonine residue 172 of the alpha subunit of the AMPK heterotrimer, activating it. LKB1, a serine/threonine kinase, was first identified as the gene whose mutation is associated with the Peutz-Jeghers familial cancer syndrome. This disease phenotype is consistent with the hypothesis that the interaction between LKB1 and AMPK normally plays a key role in the negative regulation of cell growth (Hardie 2004).

UnificationXref6741
type: UnificationXref
id: REACT_121744
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_121744.1

UniProt:Q55G10
type: ProteinReference
xref: UnificationXref8931
organism: Dictyostelium discoideum

UnificationXref8511
type: UnificationXref
id: 499997
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=499997

Evidence1117
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10698692
comment: At the beginning of this reaction, 1 molecule of 'AMPK heterotrimer (inactive)', and 1 molecule of 'AMP' are present. At the end of this reaction, 1 molecule of 'AMPK heterotrimer:AMP' is present. This reaction takes place in the 'nucleus'.

UnificationXref6740
type: UnificationXref
id: 1500593
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500593

UnificationXref8510
type: UnificationXref
id: REACT_4611
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4611.2

Evidence1119
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12829246
xref: http://identifiers.org/pubmed/10698692
xref: http://identifiers.org/pubmed/15509864
xref: http://identifiers.org/pubmed/11724780
comment: AMP-activated protein kinase (AMPK) is a sensor of cellular energy levels. A high cellular ratio of AMP:ATP triggers the phosphorylation and activation of AMPK. Activated AMPK in turn phosphorylates a wide array of target proteins, as shown in the figure below (reproduced from (Hardie et al. 2003), with the permission of D.G. Hardie). These targets include ChREBP (Carbohydrate Response Element Binding Protein), whose inactivation by phosphorylation reduces transcription of key enzymes of the glycolytic and lipogenic pathways.

UnificationXref8515
type: UnificationXref
id: REACT_5210
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5210.2

UnificationXref4601
type: UnificationXref
id: 3643897
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643897

UnificationXref6744
type: UnificationXref
id: 3649615
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649615

UnificationXref8516
type: UnificationXref
id: CHEBI:18075
db: ChEBI

UnificationXref4602
type: UnificationXref
id: REACT_108871
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108871.9

UnificationXref6745
type: UnificationXref
id: REACT_134075
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134075.5

Diphosphatidylglycerol
type: SmallMoleculeReference
name: cardiolipin
name: cardiolipin [ChEBI:28494]
name: cardiolipins
name: 1',3'-Bis(1,2-diacyl-sn-glycero-3-phospho)-sn-glycerol
xref: UnificationXref7027

UnificationXref8513
type: UnificationXref
id: CHEBI:28850
db: ChEBI

UnificationXref4603
type: UnificationXref
id: 3643898
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643898

UnificationXref6742
type: UnificationXref
id: 3649612
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649612

UnificationXref8514
type: UnificationXref
id: 110093
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110093

UnificationXref4604
type: UnificationXref
id: 3643917
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643917

UnificationXref6743
type: UnificationXref
id: 3649613
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649613

http://identifiers.org/pubmed/19073728
type: PublicationXref
id: 19073728
author: Lenschow, DJ
author: Virgin, HW
author: Giannakopoulos, NV
author: Lai, C
author: Haas, AL
author: Arutyunova, E
db: Pubmed
title: ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus
source: J Virol 83:1602-10
year: 2009

UnificationXref8519
type: UnificationXref
id: 499999
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=499999

UnificationXref6748
type: UnificationXref
id: CHEBI:16000
db: ChEBI

UnificationXref6749
type: UnificationXref
id: 1498751
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1498751

UnificationXref8517
type: UnificationXref
id: 110095
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110095

UnificationXref6746
type: UnificationXref
id: 3652297
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652297

http://identifiers.org/pubmed/8662720
type: PublicationXref
id: 8662720
author: Korenberg, J
author: Garrow, TA
author: Qi, H
author: Choi, YJ
author: Shane, B
author: Chen, L
db: Pubmed
title: Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
source: J Biol Chem 271:13077-87
year: 1996

UnificationXref8518
type: UnificationXref
id: REACT_2972
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2972.2

UnificationXref4600
type: UnificationXref
id: 3643896
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643896

UnificationXref6747
type: UnificationXref
id: REACT_140466
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140466.5

UnificationXref4609
type: UnificationXref
id: 3643902
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643902

SequenceSite2923
type: SequenceSite
position status: EQUAL
sequence position: 578

http://identifiers.org/pubmed/21641550
type: PublicationXref
id: 21641550
author: Wiley, Sandra E
author: Guan, Ziqiang
author: Zhang, Ji
author: Perkins, Guy A
author: Raetz, Christian R H
author: Worby, Carolyn A
author: Heacock, Philip
author: Nguyen, Oanh Kim
author: Wang, Jonathan H
author: Murphy, Anne N
author: Engel, James L
author: Dowhan, William
author: Dixon, JE
db: Pubmed
title: Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis
source: Cell Metab. 13:690-700
year: 2011

SequenceSite2922
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2921
type: SequenceSite
position status: EQUAL
sequence position: 307

SequenceSite2920
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref4605
type: UnificationXref
id: 3643918
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643918

UnificationXref4606
type: UnificationXref
id: 3643922
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643922

UnificationXref4607
type: UnificationXref
id: REACT_156791
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156791.3

DAP12 interactions
type: Pathway
data source: Provenance1
pathway component: REACT 149237.4
evidence: Evidence157
xref: UnificationXref1564
xref: UnificationXref1565
pathway order: PathwayStep152
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref4608
type: UnificationXref
id: 3643900
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643900

UnificationXref8500
type: UnificationXref
id: REACT_2602
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2602.2

UnificationXref8501
type: UnificationXref
id: 500006
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=500006

Evidence1168
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7903306
comment: Two human isoenzymes, IMP dehydrogenase 1 and 2 (IMPDH1,2) catalyze the irreversible dehydrogenation of inosine 5'-monophosphate (IMP) to form xanthosine 5'-monophosphate (XMP). The active forms of both isoenzymes are homotetramers, and they are nearly identical in their catalytic efficiencies and their susceptibility to inhibition by XMP (Carr et al. 1993; Colby et al. 1999; Hager et al. 1995). Both enzymes occur as homotetramers (Colby et al. 1999 - IMPDH2; unpubliched data in PDB 1JCN IMPDH1). A variety of experiments suggest that IMPDH1 and 2 have distinct functions in vivo. While IMPDH1 is expressed at constant levels, IMPDH2 is expressed at elevated levels in tumor cells and in mitotic normal cells. In humans, heterozygosity for mutant forms of IMPDH1 is associated with a form of retinitis pigmentosa (Bowne et al. 2002). In laboratory mice, mutations that disrupt the homologue of IMPDH1 have no obvious effect at the level of the whole organism, while ones that disrupt IMPDH2 are lethal (Gu et al. 2003). This reaction is the rate limiting step in the synthesis of guanosine 5'-monophosphate (GMP) from IMP, and GMP competitively inhibits the well-characterized bacterial IMP dehydrogenase enzyme. Evidence for an inhibitory effect of GMP on the human isoenzymes has not been reported. Rather, they appear to be inhibited by XMP; in addition, transcription of one or both IMP dehydrogenase mRNAs may be inhibited by high cellular GMP concentrations (Glesne et al. 1991).

Evidence1169
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7706277
xref: http://identifiers.org/pubmed/8089153
comment: Cytosolic GMP synthase (GMPS) catalyzes the reaction of xanthosine 5'-monophosphate (XMP), ATP, glutamine and water to form guanosine 5'-monophosphate (GMP), AMP, glutamate and pyrophosphate. GMPS is a monomer (Hirst et al. 1994; Nakamura and Lou 1995).

Evidence1166
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8567683
xref: http://identifiers.org/pubmed/18388293
xref: http://identifiers.org/pubmed/11096114
comment: The irreversible transfer of a formyl group to 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR), to yield 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR), is catalyzed by the phosphoribosylaminoimidazolecarboxamide formyltransferase activity of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase enzyme. This cytosolic protein occurs primarily as a dimer (Rayl et al. 1996; Vergis et al. 2001) and may further associate with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

Evidence1167
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8567683
xref: http://identifiers.org/pubmed/18388293
xref: http://identifiers.org/pubmed/11096114
comment: The reversible synthesis of inosine 5'-monophosphate from 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) is catalyzed by the IMP cyclohydrolase activity of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase enzyme. This cytosolic protein occurs primarily as a dimer (Rayl et al. 1996; Vergis et al. 2001) and may further associate with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

Evidence1164
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8110788
xref: http://identifiers.org/pubmed/18388293
comment: The irreversible transfer of an amino group from L-glutamine to 5'-phosphoribosylformylglycinamide (FGAR), forming 5'-phosphoribosylformylglycinamidine (FGAM) and glutamate, accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by phosphoribosylformylglycinamidine synthetase. The human enzyme has been purified and characterized biochemically (Barnes et al. 1994). Fluoresence microscopy studies of cultured human cells have shown that the enzyme is cytosolic and suggest that it may co-localize with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

Evidence1165
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11381136
xref: http://identifiers.org/pubmed/18388293
xref: http://identifiers.org/pubmed/2147474
comment: The irreversible synthesis of cytosolic 5'-phosphoribosyl-5-aminoimidazole (AIR) from 5'-phosphoribosylformylglycinamidine (FGAM), accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by the phosphoribosylaminoimidazole synthetase domain of the trifunctional protein, "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" (GART) (Aimi et al. 1990). The active form of the protein is cytosolic and may co-localize with other enzymes of de novo IMP biosynthesis under some metabolic conditions (Gooljarsingh et al. 2001; An et al. 2008).

Evidence1162
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11381136
xref: http://identifiers.org/pubmed/18388293
xref: http://identifiers.org/pubmed/2147474
comment: The synthesis of cytosolic 5-phosphoribosylglycinamide from 5-phosphoribosylamine and glycine, accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by the phosphoribosylglycinamide synthetase domain of the trifunctional protein, "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" (GART) (Aimi et al. 1990). The active form of the protein is cytosolic (Gooljarsingh et al. 2001; An et al. 2008).

Evidence1163
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11381136
xref: http://identifiers.org/pubmed/18388293
xref: http://identifiers.org/pubmed/12450384
xref: http://identifiers.org/pubmed/2147474
comment: The irreversible transfer of a formyl group to cytosolic 5-phosphoribosylglycinamide (GAR) to form 5'-phosphoribosylformylglycinamide (FGAR) is catalyzed by the phosphoribosylglycinamide formyltransferase domain of the trifunctional protein, "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" (GART) (Aimi et al. 1990; Zhang et al. 2002). Fluoresence microscopy studies of cultured human cells have shown that GART is cytosolic and suggest that it may co-localize with other enzymes of de novo IMP biosynthesis under some metabolic conditions (Gooljarsingh et al. 2001; An et al. 2008).

Evidence1160
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4726295
xref: http://identifiers.org/pubmed/4348202
comment: PRPP stimulates the dissociation of phosphoribosyl pyrophosphate amidotransferase tetramers to form dimers (Holmes et al. 1973a,b).

Evidence1161
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4726295
xref: http://identifiers.org/pubmed/18388293
xref: http://identifiers.org/pubmed/8380692
xref: http://identifiers.org/pubmed/4348202
xref: http://identifiers.org/pubmed/762062
comment: Cytosolic PPAT (phosphoribosyl pyrophosphate amidotransferase) catalyzes the reaction of 5-phospho-alpha-D-ribose 1-diphosphate (PRPP), water, and L-glutamine to form 5-phosphoribosylamine, L-glutamate, and pyrophosphate. This event is the committed step in de novo purine synthesis. The reaction itself is reversible, but it is pulled strongly in the direction of 5'-phosphoribosylamine synthesis by the irreversible hydrolysis of the pyrophosphate that is also formed in the reaction. Fluoresence microscopy studies of cultured human cells have shown that PPAT is cytosolic and suggest that it may co-localize with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008). The PPAT enzyme is inferred to be an iron-sulfur protein, like its well-characterized B. subtilis homologue, because incubation of purified enzyme with molecular oxygen or chelating agents inactivates it, and activity can be restored by incubation with ferrous iron and inorganic sulfide. The stoichiometry of the iron-sulfur moiety and its role in enzyme activity remain unknown (Itakura and Holmes 1979). The fully active form of the enzyme is a dimer, which can associate further to form a tetramer with sharply reduced activity (Holmes et al. 1973b; Iwahana et al. 1993). Interaction of the enzyme with inosine 5'-monophosphate (IMP), guanosine 5'-monophosphate (GMP), and adenosine 5'-monophosphate (AMP), end products of de novo purine biosynthesis, favors tetramer formation, while interaction with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP), a required substrate, favors formation of the active dimer. Kinetic studies suggest that the enzyme's binding site for GMP and IMP is separate from its AMP binding site (Holmes et al. 1973a).

Evidence1170
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1592113
xref: http://identifiers.org/pubmed/15786719
comment: Two isoforms of adenylosuccinate synthetase, ADSS and ADSSL1, catalyze the reaction of IMP, aspartate, and GTP to form adenylosuccinate, GDP, and orthophosphate (Powell et al. 1992; Sun et al. 2005). ADSS is a homotetramer (unpublished crystallographic data - PDB 2V40) and ADSSL1 is inferred to be a tetramer likewise.

http://identifiers.org/pubmed/15585605
type: PublicationXref
id: 15585605
author: Takeda, K
author: Akira, S
db: Pubmed
title: TIRAP/Mal, TRIF and TRAM. Differential utilization of these TIR
source: Int Immunol 17:1-14
year: 2005

UnificationXref6718
type: UnificationXref
id: 3649620
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649620

UnificationXref6717
type: UnificationXref
id: 3649618
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649618

UnificationXref6719
type: UnificationXref
id: REACT_144218
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144218.5

UnificationXref8507
type: UnificationXref
id: 3642351
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642351

UnificationXref6714
type: UnificationXref
id: REACT_125018
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125018.1

UnificationXref8506
type: UnificationXref
id: REACT_107431
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107431.9

UnificationXref6713
type: UnificationXref
id: 1500580
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500580

UnificationXref8509
type: UnificationXref
id: 109382
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109382

UnificationXref6716
type: UnificationXref
id: REACT_125378
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125378.1

UnificationXref8508
type: UnificationXref
id: REACT_82294
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_82294.9

UnificationXref6715
type: UnificationXref
id: 1500590
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500590

UniProt:Q55G06
type: ProteinReference
xref: UnificationXref2863
organism: Dictyostelium discoideum

UnificationXref8503
type: UnificationXref
id: P20425
db: UniProt

UnificationXref6710
type: UnificationXref
id: 3649732
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649732

UnificationXref8502
type: UnificationXref
id: REACT_21784
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21784.1

UniProt:Q55G04
type: ProteinReference
xref: UnificationXref760
organism: Dictyostelium discoideum

UnificationXref8505
type: UnificationXref
id: 3641780
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641780

UnificationXref6712
type: UnificationXref
id: REACT_133475
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133475.5

UnificationXref8504
type: UnificationXref
id: 3641778
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641778

UnificationXref6711
type: UnificationXref
id: 3649734
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649734

UniProt:Q55FN1
type: ProteinReference
xref: UnificationXref6832
organism: Dictyostelium discoideum

Evidence1179
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/2848805
xref: http://identifiers.org/pubmed/11083867
xref: http://identifiers.org/pubmed/10766785
xref: http://identifiers.org/pubmed/12947102
xref: http://identifiers.org/pubmed/17405878
comment: Cytosolic purine 5'-nucleotidase (NT5C2) catalyzes the hydrolysis of GMP, dGMP, IMP, and dIMP to yield the corresponding nucleosides and orthophosphate (Bianchi and Spychala 2003; Spychala et al. 1988). The active form of the enzyme is a tetramer and has an absolute requirement for magnesium ions (Spychala et al. 1988; Wallden et al. 2007). Consistent with the biochemical properties of purified enzyme, cultured cells overexpressing the enzyme from a recombinant DNA clone showed enhanced activity against inosine and guanosine monophosphates, but not adenosine monophosphate (Gazziola et al. 2001; Sala-Newby et al. 2000).

Evidence1175
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/21755941
comment: Cytosolic ADAL (Adenosine DeAminase-Like) catalyzes the reaction of N6-methyl-AMP and water to form IMP and methylamine. The active form of the enzyme is a protein monomer complexed with a zinc ion (Murakami et al. 2011).

Evidence1176
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/457664
comment: Cytosolic APRT dimer catalyzes the reaction of adenine and 5-phospho-alpha-D-ribose 1-diphosphate to form AMP and pyrophosphate (Holden et al. 1979).

Evidence1177
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6300847
comment: Cytosolic hypoxanthine-guanine phosphoribosyltransferase (HPRT1) tetramer catalyzes the reactions of guanine or hypoxanthine with PRPP to form GMP ir IMP and pyrophosphate (Holden and Kelley 1978; Jolly et al. 1983).

Evidence1178
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4620886
comment: Nucleosides and free bases generated by DNA and RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathway of purine biosynthesis. Nucleosides and free bases generated by DNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathway of purine biosynthesis. Nucleosides and free bases generated by RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathways of purine biosynthesis. Under normal conditions, DNA turnover is limited and deoxyribonucleotide salvage operates at a correspondingly low level (Watts 1974).

Evidence1171
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1574589
comment: The purine ribonucleotide inosine 5'-monophosphate (IMP) is assembled on 5-phospho-alpha-D-ribose 1-diphosphate (PRPP), with atoms derived from aspartate, glutamine, glycine, N10-formyl-tetrahydrofolate, and carbon dioxide. Although several of the individual reactions in this sequence are reversible, as indicated by the double-headed arrows in the diagram, other irreversible steps drive the pathway in the direction of IMP synthesis in the normal cell. All of these reactions are thus annotated here only in the direction of IMP synthesis. Guanosine 5'-monophosphate (GMP) and adenosine 5'-monophosphate (AMP) are synthesized from IMP.

Evidence1172
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/3182793
comment: Cytosolic adenosine deaminase (ADA) catalyzes the hydrolysis of 2'deoxyadenosine and adenosine to yield deoxyinosine and inosine, respectively, plus ammonia (Akeson et al. 1988). Unpublished crystallographic data (PDB 3IAR) indicate that the human enzyme is a monomer.

Evidence1173
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/6281270
xref: http://identifiers.org/pubmed/9843365
xref: http://identifiers.org/pubmed/2999129
xref: http://identifiers.org/pubmed/227870
comment: Cytosolic adenosine linase (ADK) catalyzes the reactions of adenosine and deoxyadenosine with ATP to yield the corresponding nucleotide monophosphates and ADP (Andres and Fox 1979). The enzyme is substantially more active on adenosine than deoxyadenosine in vitro (Hurley at al. 1985) though studies of cultured cells suggest that both reactions may be physiologically relevant (Hershfield et al. 1982). The enzyme is a monomer complexed with magnesium (Mathews et al. 1998).

Evidence1174
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9857047
xref: http://identifiers.org/pubmed/1429593
comment: Cytosolic AMP deaminase (AMPD) catalyzes the hydrolysis of AMP to yield IMP and ammonia. Three isoforms of AMPD, E, L, and M, have been identified that differ in their expression patterns in the body. All occur as tetramers and all have qualitatively the same catalytic activity, however (Bausch-Jurken et al. 1992; Mahnke-Zizelman et al. 1998).

Evidence1181
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10656833
xref: http://identifiers.org/pubmed/1999334
comment: Hydrogen peroxide is generated in the course of peroxisomal fatty acid oxidation and purine catabolism, and is rapidly converted to water and molecular oxygen by the enzyme catalase. This enzyme is widely distributed in the body, but is especially abundant in liver, kidney, and red blood cells.

Evidence1180
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10075721
xref: http://identifiers.org/pubmed/19470646
comment: Cytosolic guanine deaminase (GDA) catalyzes the reaction of guanine and water to form xanthine and ammonia (Yuan et al. 1999). The active enzyme is a homodimer (Murphy et al. 2009).

UnificationXref6729
type: UnificationXref
id: 3649803
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649803

UnificationXref6728
type: UnificationXref
id: 3649801
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649801

UniProt:Q55FN7
type: ProteinReference
xref: UnificationXref9223
organism: Dictyostelium discoideum

UnificationXref6727
type: UnificationXref
id: 3649779
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649779

UnificationXref6726
type: UnificationXref
id: 3649778
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649778

UnificationXref6725
type: UnificationXref
id: 3649777
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649777

UnificationXref6724
type: UnificationXref
id: 3649776
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649776

UnificationXref6723
type: UnificationXref
id: 3649775
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649775

UnificationXref6722
type: UnificationXref
id: 3649771
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649771

http://identifiers.org/pubmed/19489725
type: PublicationXref
id: 19489725
author: Joazeiro, CA
author: Deshaies, RJ
db: Pubmed
title: RING domain E3 ubiquitin ligases
source: Annu Rev Biochem 78:399-434
year: 2009

UnificationXref6721
type: UnificationXref
id: REACT_19536
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19536.2

UnificationXref6720
type: UnificationXref
id: 426925
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426925

Evidence1148
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16435184
xref: http://identifiers.org/pubmed/15070399
xref: http://identifiers.org/pubmed/7564244
comment: D2HDGH associated with the mitochondrial inner membrane catalyzes the FAD-dependent reaction of (R)-2-hydroxyglutarate to form 2-oxoglutarate (Achouri et al. 2004). D2HDGH mutations are associated with high levels of (R)-2-hydroxyglutarate in vivo and variable neurological symptoms (Struys et al. 2005; Wanders and Mooyer 1995)).

Evidence1149
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16435184
xref: http://identifiers.org/pubmed/3182820
comment: ADHFE1 catalyzes the reversible reaction of (R)-2-hydroxyglutarate and succinate semialdehyde to form 2-oxoglutarate and 4-hydroxybutyrate (Struys et al. 2005). The localization of human ADHFE1 to the mitochondrial matrix is inferred from the location determined experimentally for its rat homolog (Kaufman et al. 1988).

Evidence1146
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16746585
xref: http://identifiers.org/pubmed/16747180
xref: http://identifiers.org/pubmed/6773467
comment: In the citric acid or tricarboxylic acid (TCA) cycle, the acetyl group of acetyl CoA (derived primarily from oxidative decarboxylation of pyruvate, beta-oxidation of long-chain fatty acids, and catabolism of ketone bodies and several amino acids) can be completely oxidized to CO2 in reactions that also yield one high-energy phosphate bond (as GTP or ATP) and four reducing equivalents (three NADH + H+, and one FADH2). The NADH and FADH2 are then oxidized by the electron transport chain to yield nine more high-energy phosphate bonds (as ATP). All reactions of the citric acid cycle take place in the mitochondrion. Eight canonical reactions mediate the synthesis of citrate from acetyl-CoA and oxaloacetate and the metabolism of citrate to re-form oxaloacetate. Six additional reactions are included here. Three reversible reactions, the interconversions of citrate and isocitrate, of fumarate and malate, and of malate and oxaloacetate are annotated in both their canonical (forward) and reverse directions. The synthesis of succinate from succinyl-CoA can be coupled to the phosphorylation of either GDP (the canonical reaction) or ADP; both reactions are annotated. Two mitochondrial isocitrate dehydrogenase isozymes catalyze the oxidative decarboxylation of isocitrate to form alpha-ketoglutarate (2-oxoglutarate): IDH3 catalyzes the canonical reaction coupled to the reduction of NAD+, while IDH2 catalyzes the same reaction coupled to reduction of NADP+, a reaction whose normal physiological function is unclear. Both reactions are annotated. Finally, a reaction is annotated in which reducing equivalents are transferred from NADPH to NAD+ coupled to proton import across the inner mitochondrial membrane. The cyclical nature of the reactions responsible for the oxidation of acetate was first suggested by Hans Krebs, from biochemical studies of pigeon breast muscle (Krebs et al. 1938; Krebs and Eggleston 1940). Many of the molecular details of individual reactions were worked out by…

http://identifiers.org/pubmed/15063729
type: PublicationXref
id: 15063729
author: Kihara, A
author: Igarashi, Y
author: Mizutani, Y
db: Pubmed
title: Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation
source: FEBS Lett 563:93-7
year: 2004

http://identifiers.org/pubmed/8618861
type: PublicationXref
id: 8618861
author: Nevins, JR
author: DeGregori, J
author: Ohtani, K
db: Pubmed
title: Regulation of the cyclin E gene by transcription factor E2F1
source: Proc Natl Acad Sci U S A 92:12146-50
year: 1995

Evidence1147
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15548604
xref: http://identifiers.org/pubmed/15385440
xref: http://identifiers.org/pubmed/16005139
comment: L2HDGH associated with the mitochondrial inner membrane catalyzes the FAD-dependent reaction of (S)-2-hydroxyglutarate to form 2-oxoglutarate (Rzem et al. 2006). L2HDGH mutations are associated with high levels of (S)-2-hydroxyglutarate in vivo and variable neurological symptoms (Rzem et al. 2004; Topcu et al. 2004).

Evidence1140
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15946682
xref: http://identifiers.org/pubmed/9727038
xref: http://identifiers.org/pubmed/2188967
xref: http://identifiers.org/pubmed/11752427
comment: The mitochondrial alpha-ketoglutarate dehydrogenase complex catalyzes the reaction of alpha-ketoglutarate, CoASH, and NAD+ to form succinyl-CoA, CO2, and NADH. The enzyme complex contains multiple copies of three different proteins, E1 (OGDH), E2 (DLST), and E3 (DLD), each with distinct catalytic activities (Reed and Hackert 1990; Zhou et al 2001). The reaction starts with the oxidative decarboxylation of alpha ketoglutarate catalyzed by E1alpha and beta (alpha ketoglutarate dehydrogenase). Lipoamide cofactor associated with E1 is reduced at the same time. Next, the succinyl group derived from alpha ketoglutarate is transferred to coenzyme A in two steps catalyzed E2 (dihydrolipolyl transacetylase). Finally, the oxidized form of lipoamide is regenerated and electrons are transferred to NAD+ in two steps catalyzed by E3 (dihydrolipoyl dehydrogenase). The biochemical details of this reaction have been worked out with alpha ketoglutarate dehydrogenase complex and subunits purified from bovine tissue (McCartney et al. 1998). While all of the human proteins are known as predicted protein products of cloned genes, direct experimental evidence for their functions is available only for E3 (DLD) (Brautigam et al. 2005).

Evidence1141
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9765290
xref: http://identifiers.org/pubmed/13181903
xref: http://identifiers.org/pubmed/10727444
xref: http://identifiers.org/pubmed/9765291
xref: http://identifiers.org/pubmed/17668387
xref: http://identifiers.org/pubmed/15234968
comment: Mitochondrial succinate CoA ligase (ADP-forming) catalyzes the reversible conversion of succinyl CoA to succinate plus Coenzyme A, coupled to the conversion of ADP and orthophosphate to ATP. The enzyme is a heterodimer containing SUCLG1 and SUCLA2 monomers. The enzyme catalyzing the reaction in vertebrates is a heterodimer that occurs in two isoforms. The enzymes have been purified from pigeon and rat tissue and characterized in detail. Both isoforms, an alpha:betaA heterodimer and an alpha:betaG heterodimer, catalyze the reversible conversion of succinyl CoA to succinate plus Coenzyme A. The alpha:betaA heterodimer couples this conversion to the synthesis of ATP from ADP and orthophosphate, while the alpha:betaG heterodimer couples it to the synthesis of GTP from GDP and orthophosphate (Johnson et al. 1998a,b; Lambeth et al. 2004). Consistent with these results in model systems, patients homozygous for a mutant allele of the gene encoding the ADP enzyme beta subunit, SUCLA2, are deficient in succinyl CoA ligase activity (Elpeleg et al. 2005). Both isoforms are found in vivo, and appear to be expressed at different levels in various tissues. Their relative contributions to the flux of carbon atoms through the TCA cycle are unknown. Genetic and biochemical data suggest that the alpha:betaA isoform may be required to catalyze the reverse reaction, conversion of succinate, Coenzyme A, and ATP to succinyl CoA, ADP, and orthophosphate for heme biosynthesis (Furuyama and Sassa 2000).

Evidence1144
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8200987
comment: Mitochondrial fumarate hydratase catalyzes the reversible reaction of fumarate and water to form malate, the seventh step of the TCA cycle (Bourgeron et al. 1994). Unpublished crystallographic data indicate that the protein is a tetramer (PDB 3E04).

Evidence1145
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8200987
comment: Mitochondrial fumarate hydratase catalyzes the reversible reaction of malate to form fumarate and water (Bourgeron et al. 1994). Unpublished crystallographic data indicate that the protein is a tetramer (PDB 3E04).

Evidence1142
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9765290
xref: http://identifiers.org/pubmed/15877282
xref: http://identifiers.org/pubmed/13181903
xref: http://identifiers.org/pubmed/10727444
xref: http://identifiers.org/pubmed/9765291
xref: http://identifiers.org/pubmed/15234968
comment: Mitochondrial succinate CoA ligase (ADP-forming) catalyzes the reversible conversion of succinyl CoA to succinate plus Coenzyme A, coupled to the conversion of ADP and orthophosphate to ATP. The enzyme is a heterodimer containing SUCLG1 and SUCLA2 monomers. The enzyme catalyzing the reaction in vertebrates is a heterodimer that occurs in two isoforms. The enzymes have been purified from pigeon and rat tissue and characterized in detail. Both isoforms, an alpha:betaA heterodimer and an alpha:betaG heterodimer, catalyze the reversible conversion of succinyl CoA to succinate plus Coenzyme A. The alpha:betaA heterodimer couples this conversion to the synthesis of ATP from ADP and orthophosphate, while the alpha:betaG heterodimer couples it to the synthesis of GTP from GDP and orthophosphate (Johnson et al. 1998a,b; Lambeth et al. 2004). Consistent with these results in model systems, patients homozygous for a mutant allele of the gene encoding the ADP enzyme beta subunit, SUCLA2, are deficient in succinyl CoA ligase activity (Elpeleg et al. 2005). Both isoforms are found in vivo, and appear to be expressed at different levels in various tissues. Their relative contributions to the flux of carbon atoms through the TCA cycle are unknown. Genetic and biochemical data suggest that the alpha:betaA isoform may be required to catalyze the reverse reaction, conversion of succinate, Coenzyme A, and ATP to succinyl CoA, ADP, and orthophosphate for heme biosynthesis (Furuyama and Sassa 2000).

Evidence1143
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16143825
comment: The succinate dehydrogenase complex, associated with the inner mitochondrial membrane, catalyzes the dehydrogenation of succinate to fumarate, reducing the FAD cofactor bound to the enzyme. This redox potential is then used in the electron transfer chain to drive a proton motive force to generate ATP.

Bile salt and organic anion SLC transporters
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction181
evidence: Evidence648
xref: UnificationXref4753
xref: UnificationXref4754
pathway order: PathwayStep306
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UniProt:Q55FM3
type: ProteinReference
xref: UnificationXref7373
organism: Dictyostelium discoideum

UniProt:Q55FM6
type: ProteinReference
xref: UnificationXref9622
organism: Dictyostelium discoideum

Evidence1157
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Oxidation of fatty acids and pyruvate in the mitochondrial matrix yield large amounts of NADH. The respiratory electron transport chain couples the re-oxidation of this NADH to NAD+ to the export of protons from the mitochonrial matrix, generating a chemiosmotic gradient across the inner mitochondrial membrane. This gradient is used to drive the synthesis of ATP; it can also be bypassed by uncoupling proteins to generate heat, a reaction in brown fat that may be important in regulation of body temperature in newborn children.

Evidence1158
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: The metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalents are re-oxidized back to NAD+ in the electron transport chain (ETC), coupling this process with the export of protons across the inner mitochondrial membrane. The chemiosmotic gradient created is used to drive ATP synthesis.

Evidence1159
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/4726295
xref: http://identifiers.org/pubmed/4348202
comment: Cytosolic AMP, GMP, and IMP stimulate the association of phosphoribosyl pyrophosphate amidotransferase (PPAT) dimers to form tetramers (Holmes et al. 1973a,b).

Evidence1150
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16435184
xref: http://identifiers.org/pubmed/3182820
comment: ADHFE1 catalyzes the reversible reaction of 2-oxoglutarate and 4-hydroxybutyrate to form (R)-2-hydroxyglutarate and succinate semialdehyde (Struys et al. 2005). The localization of human ADHFE1 to the mitochondrial matrix is inferred from the location determined experimentally for its rat homolog (Kaufman et al. 1988).

Evidence1151
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18772396
xref: http://identifiers.org/pubmed/19935646
xref: http://identifiers.org/pubmed/16601864
comment: The two stereoisomers of 2-hydroxyglutarate are normally converted to 2-oxoglutarate in the mitochondrial matrix, and can then be metabolized by the citric acid cycle. The physiological sources of 2-hydroxyglutarate have not been established although plausible hypotheses are that it is generated by lysine breakdown or as a byproduct of delta-aminolevulinate metabolism. The stereoisomers are oxidized to 2-oxoglutarate in FAD-dependent reactions catalyzed by the enzymes D2HGDH (specific for R(-)-2-hydroxyglutarate) and L2HGDH (specific for S(-)-2-hydroxyglutarate). An inherited deficiency in either enzyme is associated with accumulation of 2-hydroxyglutarate and variable neurological symptoms. R(-)-2-hydroxyglutarate also reacts reversibly with succinate semialdehyde to form 4-hydroxybutyrate and 2-oxoglutarate, catalyzed by ADHFE1. No deficiencies of this enzyme have been found in patients with elevated 2-hydroxyglutarate levels (Struys 2006).

Evidence1152
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Pyruvate metabolism and the citric acid (TCA) cycle together link the processes of energy metabolism in a human cell with one another and with key biosynthetic reactions. Pyruvate, derived from the reversible oxidation of lactate or transamination of alanine, can be converted to acetyl CoA. Other sources of acetyl CoA include breakdown of free fatty acids and ketone bodies in the fasting state. Acetyl CoA can enter the citric acid cycle, a major source of reducing equivalents used to synthesize ATP, or enter biosynthetic pathways. In addition to its role in energy generation, the citric acid cycle is a source of carbon skeletons for amino acid metabolism and other biosynthetic processes. One such process included here is the interconversion of 2-hydroxyglutarate, probably derived from porphyrin and amino acid metabolism, and 2-oxoglutarate (alpha-ketoglutarate), a citric acid cycle intermediate.

Evidence1153
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8682198
comment: This event is deduced on the basis of bovine experimental data. Complex II (succinate dehydrogenase) transfers electrons from the TCA cycle to ubiquinone. The 6th step in the TCA cycle is where succinate is dehydrogenated to fumarate with subsequent reduction of FAD to FADH2. FADH2 provides the electrons for the transport chain. Succinate dehydrogenase belongs to subclass 1 of the SQR family (succinate:quinone reductase) (classified by Hagerhall, C and Hederstedt, L [1996]). It consists of 4 subunits (referred to as A, B, C and D), all nuclear-encoded and is located on the matrix side of the inner mitochondrial membrane. Subunits A and B are hydrophilic whereas subunits C and D are integral proteins of the inner membrane. SQRs usually contain 3 Fe-S clusters bound by the B subunit. Succinate dehydrogenase contains one [2Fe-2S] cluster, one [4Fe-4S] cluster and one [3Fe-4S] cluster. Additionally, the A subunit has a covalently-bound FAD group. Reduced complex II has this FAD converted to FADH2. The electrons from complex II are transferred to ubiquinone (also called Q, Coenzyme Q or CoQ), a small mobile carrier of electrons located within the inner membrane. Ubiquinone is reduced to ubiquinol during this process.

Evidence1154
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: Electron transfer flavoprotein, ETF, a 63kDa heterodimer composed of alpha and beta subunit, binds one FAD and one AMP per dimer. ETF resides on the matrix face of the mitochondrial inner membrane. Reducing equivalents from the beta-oxidation of fatty acyl CoAs are transferred to ETF, reducing the ETF-bound FAD to FADH2.

Evidence1155
type: Evidence
evidence code: EvidenceCodeVocabulary1
comment: ETF-ubiquinone oxidoreductase (ETF-QO), catalyzes the re-oxidation of reduced ETF, with ubiquinone as the electron acceptor.

Evidence1156
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref2128
xref: PublicationXref2129
xref: http://identifiers.org/pubmed/10647174
xref: PublicationXref2130
xref: http://identifiers.org/pubmed/2862839
xref: PublicationXref2126
xref: PublicationXref2125
comment: Mitochondria are often described as the "powerhouse" of a cell as it is here that energy is largely released from the oxidation of food. Reducing equivalents generated from beta-oxidation of fatty acids and from the Krebs cycle enter the electron transport chain (also called the respiratory chain). During a series of redox reactions, electrons travel down the chain releasing their energy in controlled steps. These reactions drive the active transport of H+ ions from the mitochondrial matrix , through the inner membrane to the intermembrane space. The respiratory chain consists of five main types of carrier; flavins, iron-sulfur centres, quinones, cytochromes (heme proteins) and copper. The two main reducing equivalents entering the respiratory chain are NADH and FADH2. NADH is linked through the NADH-specific dehydrogenase whereas FADH2 is reoxidised within succinate dehydrogenase and a ubiquinone reductase of the fatty acid oxidation pathway. Oxygen is the final acceptor of electrons and with H+ ions, is converted to form water, the end product of aerobic cellular respiration. A proton electrochemical gradient (often called protonmotive force) is established across the inner membrane, with positive charge in the intermembrane space relative to the matrix. Protons driven by the proton-motive force, can enter ATP synthase thus returning to the mitochondrial matrix. ATP synthases use this exergonic flow to form ATP in the matrix, a process called chemiosmotic coupling. A by-product of this process is heat generation. An antiport, ATP-ADP translocase, preferentially exports ATP from the matrix thereby maintaining a high ADP:ATP ratio in the matrix. The tight coupling of electron flow to ATP synthesis means oxygen consumption is dependent on ADP availability (termed respiratory control). High ADP (low ATP) increases electron flow thereby increasing oxygen consumption and low ADP (high ATP) decreases electron flow and thereby decreases oxygen consumption. There are many …

UnificationXref6709
type: UnificationXref
id: REACT_2351
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2351.3

UnificationXref6708
type: UnificationXref
id: 75973
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=75973

UnificationXref6707
type: UnificationXref
id: REACT_93439
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93439.9

UnificationXref6706
type: UnificationXref
id: 3652038
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652038

Mitochondrial ABC transporters
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction158
pathway component: BiochemicalReaction157
evidence: Evidence284
xref: UnificationXref2684
xref: UnificationXref2683
pathway order: PathwayStep272
pathway order: PathwayStep273
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

http://identifiers.org/pubmed/1756912
type: PublicationXref
id: 1756912
author: Morgan, R
author: Rees, A
author: Choi, WH
author: Moller, DE
author: O'Rahilly, S
author: Buse, JB
author: Flier, JS
db: Pubmed
title: Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects
source: Diabetes 40:1712-8
year: 1991

http://identifiers.org/pubmed/9461603
type: PublicationXref
id: 9461603
author: Aguado, B
author: Campbell, RD
db: Pubmed
title: Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex
source: J Biol Chem 273:4096-105
year: 1998

UnificationXref6701
type: UnificationXref
id: REACT_114625
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114625.8

UnificationXref6700
type: UnificationXref
id: 3652043
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652043

UniProt:Q55FL3
type: ProteinReference
xref: UnificationXref2373
organism: Dictyostelium discoideum

UniProt:Q55FL5
type: ProteinReference
xref: UnificationXref7605
organism: Dictyostelium discoideum

UnificationXref6705
type: UnificationXref
id: REACT_85028
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85028.9

UnificationXref6704
type: UnificationXref
id: 3652036
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652036

UnificationXref6703
type: UnificationXref
id: REACT_83477
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83477.9

UnificationXref6702
type: UnificationXref
id: 3652035
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652035

UnificationXref2319
type: UnificationXref
id: REACT_126517
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126517.5

UnificationXref2317
type: UnificationXref
id: REACT_89222
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89222.9

UnificationXref2318
type: UnificationXref
id: 3642326
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642326

UnificationXref2311
type: UnificationXref
id: 3642317
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642317

UnificationXref2312
type: UnificationXref
id: 3642322
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642322

UnificationXref2310
type: UnificationXref
id: 3642316
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642316

UnificationXref2315
type: UnificationXref
id: 3642323
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642323

UnificationXref2316
type: UnificationXref
id: 3642324
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642324

UnificationXref2313
type: UnificationXref
id: 3642325
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642325

UnificationXref2314
type: UnificationXref
id: REACT_96597
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96597.9

UnificationXref2328
type: UnificationXref
id: REACT_83491
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83491.9

UnificationXref2329
type: UnificationXref
id: 3651761
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651761

UnificationXref2320
type: UnificationXref
id: 72156
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72156

UnificationXref2321
type: UnificationXref
id: REACT_2708
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2708.1

http://identifiers.org/pubmed/18043707
type: PublicationXref
id: 18043707
author: Hamm, HE
author: Oldham, WM
db: Pubmed
title: Heterotrimeric G protein activation by G-protein-coupled receptors
source: Nat Rev Mol Cell Biol 9:60-71
year: 2008

UnificationXref2322
type: UnificationXref
id: 3642327
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642327

UnificationXref2323
type: UnificationXref
id: 3642328
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642328

UnificationXref2324
type: UnificationXref
id: REACT_86170
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86170.9

UnificationXref2325
type: UnificationXref
id: 3651835
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651835

UnificationXref2326
type: UnificationXref
id: REACT_34020
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34020.10

UnificationXref2327
type: UnificationXref
id: 3651760
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651760

UniProt:Q8T154
type: ProteinReference
xref: UnificationXref8387
organism: Dictyostelium discoideum

http://identifiers.org/pubmed/8755573
type: PublicationXref
id: 8755573
author: Webster, MK
author: Meyer, AN
author: Donoghue, DJ
author: Hart, KC
author: Galvin, BD
db: Pubmed
title: Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras
source: Proc Natl Acad Sci U S A 93:7894-9
year: 1996

Lysine catabolism
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction885
pathway component: BiochemicalReaction888
pathway component: BiochemicalReaction886
pathway component: BiochemicalReaction883
pathway component: BiochemicalReaction887
pathway component: BiochemicalReaction889
pathway component: BiochemicalReaction890
pathway component: BiochemicalReaction884
evidence: Evidence1347
xref: UnificationXref9401
xref: RelationshipXref1142
xref: UnificationXref9402
pathway order: PathwayStep1325
pathway order: PathwayStep1323
pathway order: PathwayStep1321
pathway order: PathwayStep1328
pathway order: PathwayStep1326
pathway order: PathwayStep1324
pathway order: PathwayStep1327
pathway order: PathwayStep1322
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

PublicationXref2863
type: PublicationXref
id: 8276860
author: Cerione, RA
author: Aaronson, SA
author: Eva, A
author: Evans, T
author: Zheng, Y
author: Zangrilli, D
author: Hart, MJ
db: Pubmed
title: Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product
source: J Biol Chem 269:62-5
year: 1994

RNA Polymerase II holoenzyme complex (phosphorylated) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry564
component stoichiometry: Stoichiometry561
component stoichiometry: Stoichiometry555
component stoichiometry: Stoichiometry557
component stoichiometry: Stoichiometry563
component stoichiometry: Stoichiometry562
component stoichiometry: Stoichiometry554
component stoichiometry: Stoichiometry553
component stoichiometry: Stoichiometry560
component stoichiometry: Stoichiometry559
component stoichiometry: Stoichiometry558
component stoichiometry: Stoichiometry556
component: Protein646
component: Protein639
component: Protein647
component: Protein636
component: Protein645
component: Protein644
component: Protein637
component: Protein643
component: Protein642
component: Protein638
component: Protein641
component: Protein640
xref: UnificationXref1986
cellular location: GO:0005654
comment: Reactome DB_ID: 3640986

TFIIF (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry551
component stoichiometry: Stoichiometry550
component: Protein634
component: Protein635
xref: UnificationXref1966
cellular location: GO:0005654
comment: Reactome DB_ID: 3640995

CAK (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry572
component stoichiometry: Stoichiometry574
component stoichiometry: Stoichiometry573
component: Protein653
component: PhysicalEntity70
component: Protein652
xref: UnificationXref2003
cellular location: GO:0005654
comment: Reactome DB_ID: 3641947

TFIIH (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry575
component stoichiometry: Stoichiometry569
component stoichiometry: Stoichiometry576
component stoichiometry: Stoichiometry571
component stoichiometry: Stoichiometry570
component stoichiometry: Stoichiometry578
component stoichiometry: Stoichiometry577
component: Protein654
component: Protein650
component: Protein651
component: Protein655
component: Protein656
component: Protein649
component: CAK (name copied from entity in Homo sapiens)
xref: UnificationXref2010
cellular location: GO:0005654
comment: Reactome DB_ID: 3641972

DNA polymerase alpha:primase:DNA polymerase alpha:origin complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry547
component stoichiometry: Stoichiometry546
component: DNA polymerase epsilon:origin complex (name copied from entity in Homo sapiens)
component: DNA polymerase alpha:primase (name copied from entity in Homo sapiens)
xref: UnificationXref1946
cellular location: GO:0005654
comment: Reactome DB_ID: 3639819

DNA polymerase epsilon (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry544
component stoichiometry: Stoichiometry543
component: Protein632
component: Protein631
xref: UnificationXref1944
cellular location: GO:0005654
comment: Reactome DB_ID: 3639817

RNA polymerase II (phosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry552
component stoichiometry: Stoichiometry565
component: TFIIF (name copied from entity in Homo sapiens)
component: RNA Polymerase II holoenzyme complex (phosphorylated) (name copied from entity in Homo sapiens)
xref: UnificationXref1987
cellular location: GO:0005654
comment: Reactome DB_ID: 3640996

CE:Pol II CTD:Spt5 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry567
component stoichiometry: Stoichiometry568
component stoichiometry: Stoichiometry579
component stoichiometry: Stoichiometry548
component stoichiometry: Stoichiometry566
component stoichiometry: Stoichiometry549
component: PhysicalEntity69
component: Protein633
component: PhysicalEntity68
component: Protein648
component: RNA polymerase II (phosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: TFIIH (name copied from entity in Homo sapiens)
xref: UnificationXref2011
cellular location: GO:0005654
comment: Reactome DB_ID: 3642680

Capping complex (initial) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry582
component stoichiometry: Stoichiometry581
component stoichiometry: Stoichiometry580
component: PhysicalEntity72
component: CE:Pol II CTD:Spt5 complex (name copied from entity in Homo sapiens)
component: PhysicalEntity71
xref: UnificationXref2016
cellular location: GO:0005654
comment: Reactome DB_ID: 3642682

Capping complex (hydrolyzed) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry585
component stoichiometry: Stoichiometry583
component stoichiometry: Stoichiometry584
component: PhysicalEntity73
component: PhysicalEntity72
component: CE:Pol II CTD:Spt5 complex (name copied from entity in Homo sapiens)
xref: UnificationXref2021
cellular location: GO:0005654
comment: Reactome DB_ID: 3642684

Capping complex (intermediate) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry590
component stoichiometry: Stoichiometry589
component stoichiometry: Stoichiometry586
component: PhysicalEntity73
component: PhysicalEntity72
component: Covalent CE:GMP intermediate complex (name copied from entity in Homo sapiens)
xref: UnificationXref2032
cellular location: GO:0005654
comment: Reactome DB_ID: 3642688

http://identifiers.org/pubmed/10781593
type: PublicationXref
id: 10781593
author: Kinoshita, T
author: Watanabe, R
author: Hong, Y
author: Maeda, Y
author: Inoue, N
author: Ohishi, K
db: Pubmed
title: Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol
source: J Biol Chem 275:20911-9
year: 2000

UnificationXref2306
type: UnificationXref
id: REACT_2916
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2916.1

UnificationXref2307
type: UnificationXref
id: 3642315
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642315

UnificationXref2308
type: UnificationXref
id: 77471
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77471

http://identifiers.org/pubmed/16182515
type: PublicationXref
id: 16182515
author: Hubbard, KB
author: Hepler, JR
db: Pubmed
title: Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins
source: Cell Signal 18:135-50
year: 2006

UnificationXref2309
type: UnificationXref
id: REACT_5715
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5715.1

UnificationXref2302
type: UnificationXref
id: 3642318
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642318

Stem-looped mRNA:ACF complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry607
component stoichiometry: Stoichiometry608
component: PhysicalEntity77
component: Protein659
xref: UnificationXref2073
cellular location: GO:0005654
comment: Reactome DB_ID: 3642730

UnificationXref2303
type: UnificationXref
id: 3642320
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642320

RNA Pol II with phosphorylated CTD: CE complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry606
component stoichiometry: Stoichiometry603
component stoichiometry: Stoichiometry604
component stoichiometry: Stoichiometry605
component: PhysicalEntity69
component: PhysicalEntity68
component: RNA polymerase II (phosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
component: TFIIH (name copied from entity in Homo sapiens)
xref: UnificationXref2060
cellular location: GO:0005654
comment: Reactome DB_ID: 3642665

UnificationXref2304
type: UnificationXref
id: 3642321
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642321

capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry601
component stoichiometry: Stoichiometry602
component: RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA (name copied from entity in Homo sapiens)
component: Cap Binding Complex (CBC) (name copied from entity in Homo sapiens)
xref: UnificationXref2055
cellular location: GO:0005654
comment: Reactome DB_ID: 3640998

UnificationXref2305
type: UnificationXref
id: 77461
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77461

RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry599
component stoichiometry: Stoichiometry600
component: PhysicalEntity76
component: RNA polymerase II (phosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
xref: UnificationXref2054
cellular location: GO:0005654
comment: Reactome DB_ID: 3640997

Cap Binding Complex (CBC) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry597
component stoichiometry: Stoichiometry598
component: Protein658
component: Protein657
xref: UnificationXref2051
cellular location: GO:0005654
comment: Reactome DB_ID: 3640936

Capping complex (with freed 5'- GMP) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry596
component stoichiometry: Stoichiometry595
component stoichiometry: Stoichiometry594
component: PhysicalEntity72
component: CE:Pol II CTD:Spt5 complex (name copied from entity in Homo sapiens)
component: PhysicalEntity75
xref: UnificationXref2044
cellular location: GO:0005654
comment: Reactome DB_ID: 3642694

UnificationXref2300
type: UnificationXref
id: 77464
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77464

Capping complex (GpppN..) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry593
component stoichiometry: Stoichiometry591
component stoichiometry: Stoichiometry592
component: PhysicalEntity72
component: CE:Pol II CTD:Spt5 complex (name copied from entity in Homo sapiens)
component: PhysicalEntity74
xref: UnificationXref2039
cellular location: GO:0005654
comment: Reactome DB_ID: 3642691

UnificationXref2301
type: UnificationXref
id: REACT_4663
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4663.1

Covalent CE:GMP intermediate complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry588
component stoichiometry: Stoichiometry587
component: CE:Pol II CTD:Spt5 complex (name copied from entity in Homo sapiens)
component: SmallMolecule114
xref: UnificationXref2031
cellular location: GO:0005654
comment: Reactome DB_ID: 3642687

UniProt:Q8T137
type: ProteinReference
xref: UnificationXref8540
organism: Dictyostelium discoideum

UniProt:Q55G93
type: ProteinReference
xref: UnificationXref12395
organism: Dictyostelium discoideum

Cleavage and Polyadenylation Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry622
component stoichiometry: Stoichiometry627
component stoichiometry: Stoichiometry609
component stoichiometry: Stoichiometry618
component stoichiometry: Stoichiometry615
component stoichiometry: Stoichiometry614
component: CPSF (name copied from entity in Homo sapiens)
component: Protein662
component: CstF (name copied from entity in Homo sapiens)
component: CF II (name copied from entity in Homo sapiens)
component: Protein664
component: CF I (name copied from entity in Homo sapiens)
xref: UnificationXref2112
cellular location: GO:0005654
comment: Reactome DB_ID: 3641302

http://identifiers.org/pubmed/21944752
type: PublicationXref
id: 21944752
author: Pierrel, F
author: Lill, R
author: Webert, H
author: Mühlenhoff, U
author: Fontecave, M
author: Ozeir, M
db: Pubmed
title: Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency
source: Chem Biol 18:1134-42
year: 2011

UnificationXref6799
type: UnificationXref
id: 3649712
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649712

UnificationXref6798
type: UnificationXref
id: 3649709
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649709

UnificationXref6797
type: UnificationXref
id: REACT_123902
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123902.1

UniProt:Q55G87
type: ProteinReference
xref: UnificationXref1579
organism: Dictyostelium discoideum

UnificationXref6795
type: UnificationXref
id: REACT_122641
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122641.1

UnificationXref6796
type: UnificationXref
id: 1500591
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500591

UnificationXref6793
type: UnificationXref
id: 3649708
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649708

UnificationXref6794
type: UnificationXref
id: 1500595
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500595

UnificationXref6791
type: UnificationXref
id: Q8T2Q6
db: UniProt

UnificationXref6792
type: UnificationXref
id: 3649707
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649707

UnificationXref6790
type: UnificationXref
id: 3649703
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649703

Synthesis of glycosylphosphatidylinositol (GPI)
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1159
pathway component: BiochemicalReaction1160
pathway component: BiochemicalReaction1154
pathway component: BiochemicalReaction1157
pathway component: BiochemicalReaction1158
pathway component: BiochemicalReaction1153
pathway component: BiochemicalReaction1155
pathway component: BiochemicalReaction1156
evidence: Evidence1851
xref: UnificationXref12543
xref: UnificationXref12542
xref: RelationshipXref1457
pathway order: PathwayStep1814
pathway order: PathwayStep1816
pathway order: PathwayStep1812
pathway order: PathwayStep1815
pathway order: PathwayStep1810
pathway order: PathwayStep1811
pathway order: PathwayStep1813
pathway order: PathwayStep1809
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UniProt:Q55G81
type: ProteinReference
xref: UnificationXref2004
organism: Dictyostelium discoideum

Ensembl:DDB0188487
type: ProteinReference
xref: UnificationXref10025
organism: Dictyostelium discoideum

http://identifiers.org/pubmed/10524214
type: PublicationXref
id: 10524214
author: Cregeen, DP
author: Rumsby, G
db: Pubmed
title: Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase
source: Biochim Biophys Acta 1446:383-8
year: 1999

Ensembl:DDB0216893
type: ProteinReference
xref: UnificationXref10027
organism: Dictyostelium discoideum

Ensembl:DDB0188650
type: ProteinReference
xref: UnificationXref10033
organism: Dictyostelium discoideum

Ensembl:DDB0188580
type: ProteinReference
xref: UnificationXref10031
organism: Dictyostelium discoideum

Ensembl:DDB0238631
type: ProteinReference
xref: UnificationXref10029
organism: Dictyostelium discoideum

http://identifiers.org/pubmed/5666113
type: PublicationXref
id: 5666113
author: Luzzatto, L
author: Afolayan, A
db: Pubmed
title: Enzymic properties of different types of human erythrocyte glucose-6-phosphate dehydrogenase, with characterization of two new genetic variants
source: J Clin Invest 47:1833-42
year: 1968

UniProt:Q8T191
type: ProteinReference
xref: UnificationXref12850
organism: Dictyostelium discoideum

Adenylate cyclase inhibitory pathway
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction230
evidence: Evidence395
xref: UnificationXref3729
xref: RelationshipXref264
xref: UnificationXref3728
pathway order: PathwayStep383
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UniProt:Q8T197
type: ProteinReference
xref: UnificationXref2452
organism: Dictyostelium discoideum

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0231750
data source: Provenance1
name: Choline-phosphate cytidylyltransferase B
name: DDB0231750
name: Phosphorylcholine transferase B
name: PCYT1B
xref: UnificationXref6884
feature: FragmentFeature1445
cellular location: GO:0005789
comment: Reactome DB_ID: 3649740
display name: CCTB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0231750
data source: Provenance1
name: CCT-alpha
name: DDB0231750
name: Choline-phosphate cytidylyltransferase A
xref: UnificationXref6882
feature: FragmentFeature1444
cellular location: GO:0005789
comment: Reactome DB_ID: 3649738
display name: PCYT1A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54H80
data source: Provenance1
name: PNMT
name: PEMT2
name: PEMPT
name: Phosphatidylethanolamine N-methyltransferase
name: PEAMT
name: Q54H80
xref: UnificationXref6872
feature: FragmentFeature1443
cellular location: GO:0005789
comment: Reactome DB_ID: 3649798
display name: PEMT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0168012
data source: Provenance1
name: DDB0168012
name: Putative glycerophosphocholine phosphodiesterase GPCPD1
name: GPCPD1
name: Glycerophosphodiester phosphodiesterase 5
xref: UnificationXref6859
feature: FragmentFeature1442
cellular location: GO:0005829
comment: Reactome DB_ID: 3649763
display name: GDE5

15-Keto-PGF2a
type: SmallMoleculeReference
name: 15-Keto-prostaglandin F2alpha
name: 15-Keto-prostaglandin F2alpha [ChEBI:760]
name: 15-Keto-prostaglandin F2a
name: 15-Keto-PGF2alpha
xref: UnificationXref7405

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0217387
data source: Provenance1
name: DDB0217387
name: Putative glycerophosphocholine phosphodiesterase GPCPD1
name: GPCPD1
name: Glycerophosphodiester phosphodiesterase 5
xref: UnificationXref6857
feature: FragmentFeature1441
cellular location: GO:0005829
comment: Reactome DB_ID: 3649759
display name: GDE5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54GL1
data source: Provenance1
name: Q54GL1
name: Putative glycerophosphocholine phosphodiesterase GPCPD1
name: GPCPD1
name: Glycerophosphodiester phosphodiesterase 5
xref: UnificationXref6855
feature: FragmentFeature1440
cellular location: GO:0005829
comment: Reactome DB_ID: 3649755
display name: GDE5

Homologues of GPCPD1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref6860
cellular location: GO:0005829
comment: Reactome DB_ID: 3649764
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0304755
data source: Provenance1
name: MBOA5_HUMAN
name: MBOAT5
name: Lysophospholipid acyltransferase 5
name: DDB0304755
xref: UnificationXref6840
feature: FragmentFeature1439
cellular location: GO:0005789
comment: Reactome DB_ID: 3649607
display name: LPCAT3

UnificationXref6778
type: UnificationXref
id: 3649818
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649818

UnificationXref6777
type: UnificationXref
id: 3649817
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649817

UnificationXref6776
type: UnificationXref
id: REACT_14559
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_14559.2

UnificationXref6775
type: UnificationXref
id: 217314
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=217314

CHPT1(2-406)
type: Protein
entity reference: Q54XM0
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q54XM0
name: Cholinephosphotransferase 1
name: Diacylglycerol cholinephosphotransferase 1
name: CHPT1
xref: UnificationXref6901
feature: FragmentFeature1446
cellular location: GO:0000139
comment: Reactome DB_ID: 3649719
display name: CPT1

http://identifiers.org/pubmed/16854452
type: PublicationXref
id: 16854452
author: Wirtz, KWA
author: Schouten, A
author: Gros, P
db: Pubmed
title: Phosphatidylinositol transfer proteins: from closed for transport to open for exchange
source: Adv Enzyme Regul 46:301-11
year: 2006

UnificationXref6779
type: UnificationXref
id: 3649819
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649819

Homologues of CHPT1(2-406)
type: Protein
data source: Provenance1
member physical entity: CHPT1(2-406)
xref: UnificationXref6903
cellular location: GO:0000139
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3649721

UniProt:Q55FU2
type: ProteinReference
xref: UnificationXref74
organism: Dictyostelium discoideum

UnificationXref6770
type: UnificationXref
id: Q55BZ4
db: UniProt

UnificationXref6773
type: UnificationXref
id: 3649810
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649810

UnificationXref6774
type: UnificationXref
id: REACT_134908
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134908.5

UnificationXref6771
type: UnificationXref
id: 3649807
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649807

UnificationXref6772
type: UnificationXref
id: 3649808
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649808

20-Hydroxy arachidonic acid
type: SmallMoleculeReference
name: 20-HETE
name: 20-Hydroxyicosatetraenoic acid
name: (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
name: 20-Hydroxyeicosatetraenoic acid
name: 20-HETE [ChEBI:34306]
xref: UnificationXref7545

UnificationXref6787
type: UnificationXref
id: 109395
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109395

UnificationXref6786
type: UnificationXref
id: CHEBI:17361
db: ChEBI

UnificationXref6789
type: UnificationXref
id: Q54XM0
db: UniProt

UnificationXref6788
type: UnificationXref
id: REACT_4841
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4841.2

UnificationXref6780
type: UnificationXref
id: 3649820
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649820

UniProt:Q55FT1
type: ProteinReference
xref: UnificationXref8424
organism: Dictyostelium discoideum

UnificationXref6781
type: UnificationXref
id: 3649821
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649821

UnificationXref6782
type: UnificationXref
id: 3649823
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649823

UnificationXref6783
type: UnificationXref
id: REACT_143208
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143208.5

UnificationXref6784
type: UnificationXref
id: 1500581
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500581

UnificationXref6785
type: UnificationXref
id: REACT_124951
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124951.1

UnificationXref2286
type: UnificationXref
id: 3641306
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641306

6xSLC35D1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry889
component: Protein983
xref: UnificationXref3383
cellular location: GO:0005789
comment: Reactome DB_ID: 3644081

UnificationXref2285
type: UnificationXref
id: REACT_5157
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5157.1

Aquaporin-8 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry890
component: Protein985
xref: UnificationXref3427
cellular location: GO:0005886
comment: Reactome DB_ID: 3648043

UnificationXref2284
type: UnificationXref
id: 72073
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72073

Ensembl:DDB0231459
type: ProteinReference
xref: UnificationXref9560
organism: Dictyostelium discoideum

UnificationXref2283
type: UnificationXref
id: 3641253
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641253

http://identifiers.org/pubmed/21554866
type: PublicationXref
id: 21554866
author: Cox, Brian J
author: Biechele, Steffen
author: Rossant, Janet
db: Pubmed
title: Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos
source: Dev. Biol. 355:275-85
year: 2011

GLUT1, GLUT2, GLUT3, GLUT4
type: Complex
data source: Provenance1
member physical entity: GLUT4 tetramer (name copied from entity in Homo sapiens)
member physical entity: GLUT3 tetramer (name copied from entity in Homo sapiens)
member physical entity: GLUT1 tetramer (name copied from entity in Homo sapiens)
member physical entity: GLUT2 tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref2928
cellular location: GO:0005886
display name: GLUT tetramers
comment: Reactome DB_ID: 3640259
comment: Converted from EntitySet in Reactome

UnificationXref2282
type: UnificationXref
id: 3641222
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641222

GLUT1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry881
component: Protein892
xref: UnificationXref2919
cellular location: GO:0005886
comment: Reactome DB_ID: 3640234

UnificationXref2281
type: UnificationXref
id: 3641208
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641208

GLUT3 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry882
component: Protein899
xref: UnificationXref2927
cellular location: GO:0005886
comment: Reactome DB_ID: 3640250

UnificationXref2280
type: UnificationXref
id: DDB0233345
db: Ensembl

GLUT1:ATP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry884
component stoichiometry: Stoichiometry885
component: SmallMolecule201
component: GLUT1 tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref2935
cellular location: GO:0005886
comment: Reactome DB_ID: 3647771

http://identifiers.org/pubmed/14660610
type: PublicationXref
id: 14660610
author: White, JA
author: Ramshaw, HA
author: Petkovich, M
author: Collop, AH
author: Helvig, C
author: Korczak, B
author: Taimi, M
author: Jones, G
author: Amad, M
author: Chuang, SS
db: Pubmed
title: CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids
source: J Biol Chem 279:6305-14
year: 2004

triciribine
type: SmallMoleculeReference
name: triciribine [ChEBI:65310]
xref: UnificationXref11689

Di-peptides
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry878
component: SmallMolecule27
xref: UnificationXref2858
xref: UnificationXref2857
cellular location: GO:0005829
comment: Reactome DB_ID: 427981

Di-peptides/tri-peptides
type: Complex
data source: Provenance1
member physical entity: Tri-peptides
member physical entity: Di-peptides
xref: UnificationXref2861
xref: UnificationXref2862
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 428026

GLUT2 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry880
component: Protein546
xref: UnificationXref2909
cellular location: GO:0005886
comment: Reactome DB_ID: 3640242

Tri-peptides
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry879
component: SmallMolecule27
xref: UnificationXref2860
xref: UnificationXref2859
cellular location: GO:0005829
comment: Reactome DB_ID: 428046

UnificationXref2289
type: UnificationXref
id: 3641305
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641305

UnificationXref2287
type: UnificationXref
id: 3641303
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641303

UnificationXref2288
type: UnificationXref
id: 3641304
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641304

Tri-peptides
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry877
component: SmallMolecule179
xref: UnificationXref2853
xref: UnificationXref2854
cellular location: GO:0005576
comment: Reactome DB_ID: 427999

UnificationXref2273
type: UnificationXref
id: 3641154
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641154

UnificationXref2272
type: UnificationXref
id: 3641112
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641112

Di-peptides/tri-peptides
type: Complex
data source: Provenance1
member physical entity: Di-peptides
member physical entity: Tri-peptides
xref: UnificationXref2855
xref: UnificationXref2856
cellular location: GO:0005576
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 428037

UnificationXref2275
type: UnificationXref
id: Q54MH4
db: UniProt

Di-peptides
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry876
component: SmallMolecule179
xref: UnificationXref2852
xref: UnificationXref2851
cellular location: GO:0005576
comment: Reactome DB_ID: 427956

UnificationXref2274
type: UnificationXref
id: 3641204
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641204

ABC7 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry874
component: Protein827
xref: UnificationXref2668
cellular location: GO:0005743
comment: Reactome DB_ID: 3646433

GTP hydrolysis and joining of the 60S ribosomal subunit
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1123
pathway component: BiochemicalReaction1124
evidence: Evidence1794
xref: UnificationXref12110
xref: UnificationXref12109
pathway order: PathwayStep1758
pathway order: PathwayStep1759
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

MTABC3 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry875
component: Protein828
xref: UnificationXref2680
cellular location: GO:0005741
comment: Reactome DB_ID: 3649435

ABCG5:ABCG8 heterodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry873
component stoichiometry: Stoichiometry872
component: Protein815
component: Protein821
xref: UnificationXref2646
cellular location: GO:0005886
comment: Reactome DB_ID: 3645774

UnificationXref2271
type: UnificationXref
id: 3641107
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641107

UniProt:Q9NCL8
type: ProteinReference
xref: UnificationXref6912
organism: Dictyostelium discoideum

Heme transporters
type: Complex
data source: Provenance1
member physical entity: ABC7 dimer (name copied from entity in Homo sapiens)
xref: UnificationXref2669
cellular location: GO:0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3646434

UnificationXref2270
type: UnificationXref
id: 3641096
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641096

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54EM5
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: CYPIA2
name: Q54EM5
name: P(3)450
name: P450 4
xref: UnificationXref7484
feature: FragmentFeature1526
cellular location: GO:0005789
comment: Reactome DB_ID: 3642513
display name: CYP1A2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q86A22
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: Q86A22
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7485
feature: FragmentFeature1527
cellular location: GO:0005789
comment: Reactome DB_ID: 3642517
display name: CYP1A2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q55AJ4
data source: Provenance1
name: P450-P3
name: Cytochrome P450 1A2
name: CYPIA2
name: P(3)450
name: Q55AJ4
name: P450 4
xref: UnificationXref7486
feature: FragmentFeature1528
cellular location: GO:0005789
comment: Reactome DB_ID: 3642521
display name: CYP1A2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0302550
data source: Provenance1
name: Prostaglandin reductase 1
name: PTGR1_HUMAN
name: DDB0302550
xref: UnificationXref7423
feature: FragmentFeature1523
cellular location: GO:0005829
comment: Reactome DB_ID: 3650820
display name: PTGR1

ABCD2:ABCD3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry870
component stoichiometry: Stoichiometry871
component: Protein813
component: Protein814
xref: UnificationXref2616
cellular location: GO:0005778
comment: Reactome DB_ID: 3646446

http://identifiers.org/pubmed/19359157
type: PublicationXref
id: 19359157
author: Lykke-Andersen, J
author: Rebbapragada, I
db: Pubmed
title: Execution of nonsense-mediated mRNA decay: what defines a substrate?
source: Curr Opin Cell Biol 21:394-402
year: 2009

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P52922
data source: Provenance1
name: P52922
name: Leukotriene A-4 hydrolase-1
name: LKHA4_HUMAN
xref: UnificationXref7436
feature: FragmentFeature1524
cellular location: GO:0005829
comment: Reactome DB_ID: 3645786
display name: LTA4H

ABCD1:ABCD3 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry868
component stoichiometry: Stoichiometry869
component: Protein812
component: Protein814
xref: UnificationXref2615
cellular location: GO:0005778
comment: Reactome DB_ID: 3646445

Homologues of CYP1A2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q54DT2
member physical entity: Q1ZXG3
xref: UnificationXref7509
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3642616

ABCD1:ABCD2 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry867
component stoichiometry: Stoichiometry866
component: Protein813
component: Protein812
xref: UnificationXref2613
cellular location: GO:0005778
comment: Reactome DB_ID: 3646443

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXN4
data source: Provenance1
name: Q1ZXN4
name: P450-P3
name: Cytochrome P450 1A2
name: CYPIA2
name: P(3)450
name: P450 4
xref: UnificationXref7483
feature: FragmentFeature1525
cellular location: GO:0005789
comment: Reactome DB_ID: 3642509
display name: CYP1A2

http://identifiers.org/pubmed/18331591
type: PublicationXref
id: 18331591
author: Foster, LJ
author: Rogers, LD
db: Pubmed
title: Contributions of proteomics to understanding phagosome maturation
source: Cell Microbiol 10:1405-12
year: 2008

UnificationXref2276
type: UnificationXref
id: 3641212
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641212

Homologues of PTGR1
type: Protein
data source: Provenance1
member physical entity: DDB0217804
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7424
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3650821

UnificationXref2277
type: UnificationXref
id: O15698
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0231606
data source: Provenance1
name: Prostaglandin reductase 1
name: DDB0231606
name: PTGR1_HUMAN
xref: UnificationXref7419
feature: FragmentFeature1521
cellular location: GO:0005829
comment: Reactome DB_ID: 3650812
display name: PTGR1

UnificationXref2278
type: UnificationXref
id: 3641214
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641214

DDB0217804
type: Protein
entity reference: Ensembl:DDB0217804
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Prostaglandin reductase 1
name: PTGR1_HUMAN
xref: UnificationXref7421
feature: FragmentFeature1522
cellular location: GO:0005829
comment: Reactome DB_ID: 3650816
display name: PTGR1

UnificationXref2279
type: UnificationXref
id: 3641215
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641215

Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry854
component stoichiometry: Stoichiometry855
component: Protein732
component: Capped Intronless Histone pre-mRNA:CBC complex (name copied from entity in Homo sapiens)
xref: UnificationXref2336
cellular location: GO:0005654
comment: Reactome DB_ID: 3642714

UnificationXref2260
type: UnificationXref
id: 3641007
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641007

capped intronless pre-mRNA:CBC complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry858
component stoichiometry: Stoichiometry856
component stoichiometry: Stoichiometry857
component: PhysicalEntity133
component: Protein658
component: Protein657
xref: UnificationXref2343
cellular location: GO:0005654
comment: Reactome DB_ID: 3642718

Ensembl:DDB0231093
type: ProteinReference
xref: UnificationXref9803
organism: Dictyostelium discoideum

CPSF:capped intronless pre-mRNA:CBC complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry859
component stoichiometry: Stoichiometry860
component: CPSF (name copied from entity in Homo sapiens)
component: capped intronless pre-mRNA:CBC complex (name copied from entity in Homo sapiens)
xref: UnificationXref2344
cellular location: GO:0005654
comment: Reactome DB_ID: 3642719

Ensembl:DDB0205702
type: ProteinReference
xref: UnificationXref9788
organism: Dictyostelium discoideum

CstF:CPSF:capped intronless pre-mRNA:CBC complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry862
component stoichiometry: Stoichiometry861
component: CstF (name copied from entity in Homo sapiens)
component: CPSF:capped intronless pre-mRNA:CBC complex (name copied from entity in Homo sapiens)
xref: UnificationXref2347
cellular location: GO:0005654
comment: Reactome DB_ID: 3642721

HSD11B1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry863
component: Protein764
xref: UnificationXref2457
cellular location: GO:0005789
comment: Reactome DB_ID: 3644561

UnificationXref2264
type: UnificationXref
id: DDB0233648
db: Ensembl

HSD17B1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry864
component: Protein767
xref: UnificationXref2550
cellular location: GO:0005829
comment: Reactome DB_ID: 3648317

UnificationXref2263
type: UnificationXref
id: 3641087
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641087

Ensembl:DDB0206266
type: ProteinReference
xref: UnificationXref9848
organism: Dictyostelium discoideum

ABCD1/2/3 dimers
type: Complex
data source: Provenance1
member physical entity: ABCD2:ABCD3 (name copied from entity in Homo sapiens)
member physical entity: ABCD1:ABCD3 (name copied from entity in Homo sapiens)
member physical entity: ABCD1 homodimer (name copied from entity in Homo sapiens)
member physical entity: ABCD1:ABCD2 (name copied from entity in Homo sapiens)
xref: UnificationXref2617
cellular location: GO:0005778
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3646447

UnificationXref2262
type: UnificationXref
id: REACT_4848
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4848.1

ABCD1 homodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry865
component: Protein812
xref: UnificationXref2611
cellular location: GO:0005778
comment: Reactome DB_ID: 3646441

UnificationXref2261
type: UnificationXref
id: 72051
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72051

http://identifiers.org/pubmed/17698287
type: PublicationXref
id: 17698287
author: Grabowska, AM
author: Watson, SA
db: Pubmed
title: Role of gastrin peptides in carcinogenesis
source: Cancer Lett 257:1-15
year: 2007

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q86AU1
data source: Provenance1
name: HPGDS_HUMAN
name: Hematopoietic prostaglandin D synthase
name: Q86AU1
xref: UnificationXref7387
feature: FragmentFeature1519
cellular location: GO:0005829
comment: Reactome DB_ID: 3644200
display name: HPGDS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54VI4
data source: Provenance1
name: HPGDS_HUMAN
name: Hematopoietic prostaglandin D synthase
name: Q54VI4
xref: UnificationXref7389
feature: FragmentFeature1520
cellular location: GO:0005829
comment: Reactome DB_ID: 3644201
display name: HPGDS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q556P3
data source: Provenance1
name: HPGDS_HUMAN
name: Q556P3
name: Hematopoietic prostaglandin D synthase
xref: UnificationXref7383
feature: FragmentFeature1517
cellular location: GO:0005829
comment: Reactome DB_ID: 3644198
display name: HPGDS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54QV7
data source: Provenance1
name: HPGDS_HUMAN
name: Hematopoietic prostaglandin D synthase
name: Q54QV7
xref: UnificationXref7385
feature: FragmentFeature1518
cellular location: GO:0005829
comment: Reactome DB_ID: 3644199
display name: HPGDS

Homologues of MTMR7
type: Protein
data source: Provenance1
member physical entity: Q54GQ1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7279
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3650076

UnificationXref2267
type: UnificationXref
id: 3641120
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641120

Ensembl:DDB0231749
type: ProteinReference
xref: UnificationXref9755
organism: Dictyostelium discoideum

Q54GQ1
type: Protein
entity reference: Q54GQ1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7277
feature: FragmentFeature1513
cellular location: GO:0005829
comment: Reactome DB_ID: 3650071
display name: MTMR7

UnificationXref2268
type: UnificationXref
id: 3641121
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641121

UnificationXref2265
type: UnificationXref
id: 3641116
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641116

UnificationXref2266
type: UnificationXref
id: DDB0202577
db: Ensembl

Homologues of HPGDS
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7390
cellular location: GO:0005829
comment: Reactome DB_ID: 3644202
comment: Converted from EntitySet in Reactome

http://identifiers.org/pubmed/7378348
type: PublicationXref
id: 7378348
author: So, AG
author: Tan, CK
author: Downey, KM
author: Lee, MY
db: Pubmed
title: Purification of deoxyribonucleic acid polymerase delta from calf thymus: partial characterization of physical properties.
source: Biochemistry 19:2096-101
year: 1980

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q556G3
data source: Provenance1
name: HPGDS_HUMAN
name: Q556G3
name: Hematopoietic prostaglandin D synthase
xref: UnificationXref7381
feature: FragmentFeature1516
cellular location: GO:0005829
comment: Reactome DB_ID: 3644197
display name: HPGDS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q55AZ2
data source: Provenance1
name: Q55AZ2
xref: UnificationXref7278
feature: FragmentFeature1514
cellular location: GO:0005829
comment: Reactome DB_ID: 3650075
display name: MTMR7

Capped Intronless Histone pre-mRNA:CBC complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry853
component stoichiometry: Stoichiometry852
component: PhysicalEntity132
component: Cap Binding Complex (CBC) (name copied from entity in Homo sapiens)
xref: UnificationXref2333
cellular location: GO:0005654
comment: Reactome DB_ID: 3642709

UnificationXref2269
type: UnificationXref
id: 3641079
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641079

PTGES3
type: Protein
entity reference: UniProt:Q55FM3
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Prostaglandin E synthase 3
name: Q55FM3
xref: UnificationXref7374
feature: FragmentFeature1515
cellular location: GO:0005829
comment: Reactome DB_ID: 3645730
display name: cPGES

post exon ligation complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry849
component stoichiometry: Stoichiometry846
component stoichiometry: Stoichiometry850
component stoichiometry: Stoichiometry851
component stoichiometry: Stoichiometry847
component stoichiometry: Stoichiometry848
component: PhysicalEntity101
component: PhysicalEntity131
component: PhysicalEntity98
component: capped, methylated pre-mRNA:CBC Complex (name copied from entity in Homo sapiens)
component: PhysicalEntity113
component: PhysicalEntity89
xref: UnificationXref2322
cellular location: GO:0005654
comment: Reactome DB_ID: 3642327

U6 ATAC snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry816
component stoichiometry: Stoichiometry815
component: PhysicalEntity127
component: snRNP Sm core complex (name copied from entity in Homo sapiens)
xref: UnificationXref2299
cellular location: GO:0005654
comment: Reactome DB_ID: 3642319

Transport of nucleotide sugars
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction212
pathway component: BiochemicalReaction208
pathway component: BiochemicalReaction210
pathway component: BiochemicalReaction213
pathway component: BiochemicalReaction209
pathway component: BiochemicalReaction211
evidence: Evidence356
xref: UnificationXref3414
xref: UnificationXref3415
pathway order: PathwayStep344
pathway order: PathwayStep341
pathway order: PathwayStep345
pathway order: PathwayStep342
pathway order: PathwayStep340
pathway order: PathwayStep343
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

U4 ATAC snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry818
component stoichiometry: Stoichiometry819
component: snRNP Sm core complex (name copied from entity in Homo sapiens)
component: PhysicalEntity128
xref: UnificationXref2302
cellular location: GO:0005654
comment: Reactome DB_ID: 3642318

U4 ATAC:U5:U6 ATAC Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry814
component stoichiometry: Stoichiometry821
component: U5 snRNP (name copied from entity in Homo sapiens)
component: U4 ATAC snRNP:U6 ATAC snRNP (name copied from entity in Homo sapiens)
xref: UnificationXref2304
cellular location: GO:0005654
comment: Reactome DB_ID: 3642321

U4 ATAC snRNP:U6 ATAC snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry820
component stoichiometry: Stoichiometry817
component: U4 ATAC snRNP (name copied from entity in Homo sapiens)
component: U6 ATAC snRNP (name copied from entity in Homo sapiens)
xref: UnificationXref2303
cellular location: GO:0005654
comment: Reactome DB_ID: 3642320

U12 snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry833
component stoichiometry: Stoichiometry831
component stoichiometry: Stoichiometry830
component stoichiometry: Stoichiometry832
component: Protein696
component: snRNP Sm core complex (name copied from entity in Homo sapiens)
component: SF3B (name copied from entity in Homo sapiens)
component: PhysicalEntity130
xref: UnificationXref2310
cellular location: GO:0005654
comment: Reactome DB_ID: 3642316

UnificationXref2251
type: UnificationXref
id: DDB0233749
db: Ensembl

ATAC B Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry836
component stoichiometry: Stoichiometry835
component: ATAC A Complex (name copied from entity in Homo sapiens)
component: U4 ATAC:U5:U6 ATAC Complex (name copied from entity in Homo sapiens)
xref: UnificationXref2312
cellular location: GO:0005654
comment: Reactome DB_ID: 3642322

UnificationXref2250
type: UnificationXref
id: 3641093
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641093

ATAC A Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry827
component stoichiometry: Stoichiometry828
component stoichiometry: Stoichiometry822
component stoichiometry: Stoichiometry826
component stoichiometry: Stoichiometry829
component stoichiometry: Stoichiometry823
component stoichiometry: Stoichiometry834
component: U12 snRNP (name copied from entity in Homo sapiens)
component: PhysicalEntity101
component: PhysicalEntity98
component: U11 snRNP (name copied from entity in Homo sapiens)
component: capped, methylated pre-mRNA:CBC Complex (name copied from entity in Homo sapiens)
component: PhysicalEntity113
component: PhysicalEntity89
xref: UnificationXref2311
cellular location: GO:0005654
comment: Reactome DB_ID: 3642317

UnificationXref2253
type: UnificationXref
id: 3641111
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641111

Ensembl:DDB0234079
type: ProteinReference
xref: UnificationXref9697
organism: Dictyostelium discoideum

U11 snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry824
component stoichiometry: Stoichiometry825
component: PhysicalEntity129
component: snRNP Sm core complex (name copied from entity in Homo sapiens)
xref: UnificationXref2307
cellular location: GO:0005654
comment: Reactome DB_ID: 3642315

UnificationXref2252
type: UnificationXref
id: 3641146
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641146

ATAC C Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry837
component stoichiometry: Stoichiometry844
component stoichiometry: Stoichiometry843
component stoichiometry: Stoichiometry842
component stoichiometry: Stoichiometry845
component stoichiometry: Stoichiometry840
component stoichiometry: Stoichiometry838
component stoichiometry: Stoichiometry839
component stoichiometry: Stoichiometry841
component: U12 snRNP (name copied from entity in Homo sapiens)
component: PhysicalEntity101
component: PhysicalEntity98
component: U11 snRNP (name copied from entity in Homo sapiens)
component: U5 snRNP (name copied from entity in Homo sapiens)
component: capped, methylated pre-mRNA:CBC Complex (name copied from entity in Homo sapiens)
component: U6 ATAC snRNP (name copied from entity in Homo sapiens)
component: PhysicalEntity113
component: PhysicalEntity89
xref: UnificationXref2315
cellular location: GO:0005654
comment: Reactome DB_ID: 3642323

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q55EE1
data source: Provenance1
name: KIAA1073
name: Q55EE1
xref: UnificationXref7249
feature: FragmentFeature1508
cellular location: GO:0005829
comment: Reactome DB_ID: 3650065
display name: MTMR2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q55E04
data source: Provenance1
name: KIAA1073
name: Q55E04
xref: UnificationXref7250
feature: FragmentFeature1509
cellular location: GO:0005829
comment: Reactome DB_ID: 3650066
display name: MTMR2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0188326
data source: Provenance1
name: VAC14
name: DDB0188326
name: ArPIKfyve
name: TAX1BP2
name: VAC14_HUMAN
name: Protein VAC14 homolog
xref: UnificationXref7267
feature: FragmentFeature1510
cellular location: GO:0031902
comment: Reactome DB_ID: 3650108
display name: TRX

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B0G126
data source: Provenance1
name: 1-phosphatidylinositol-3-phosphate 5-kinase
name: PIKFYVE
name: FYV1_HUMAN
name: B0G126
name: KIAA0981
xref: UnificationXref7268
feature: FragmentFeature1511
cellular location: GO:0031902
comment: Reactome DB_ID: 3650104
display name: PIP5K3

DDB0205575
type: Protein
entity reference: Ensembl:DDB0205575
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SAC3
name: Polyphosphoinositide phosphatase
name: FIG4_HUMAN
xref: UnificationXref7269
feature: FragmentFeature1512
cellular location: GO:0031902
comment: Reactome DB_ID: 3650100
display name: FIG4

UnificationXref2254
type: UnificationXref
id: DDB0233771
db: Ensembl

UnificationXref2255
type: UnificationXref
id: 3641138
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641138

UnificationXref2256
type: UnificationXref
id: 3641088
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641088

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54PL3
data source: Provenance1
name: Q54PL3
name: KIAA1073
xref: UnificationXref7244
feature: FragmentFeature1503
cellular location: GO:0005829
comment: Reactome DB_ID: 3650060
display name: MTMR2

UnificationXref2257
type: UnificationXref
id: DDB0233764
db: Ensembl

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54TD5
data source: Provenance1
name: Q54TD5
name: KIAA1073
xref: UnificationXref7245
feature: FragmentFeature1504
cellular location: GO:0005829
comment: Reactome DB_ID: 3650061
display name: MTMR2

hnRNP proteins (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry768
component stoichiometry: Stoichiometry783
component stoichiometry: Stoichiometry781
component stoichiometry: Stoichiometry766
component stoichiometry: Stoichiometry777
component stoichiometry: Stoichiometry782
component stoichiometry: Stoichiometry774
component stoichiometry: Stoichiometry770
component stoichiometry: Stoichiometry767
component stoichiometry: Stoichiometry776
component stoichiometry: Stoichiometry769
component stoichiometry: Stoichiometry771
component stoichiometry: Stoichiometry772
component stoichiometry: Stoichiometry779
component stoichiometry: Stoichiometry778
component stoichiometry: Stoichiometry765
component stoichiometry: Stoichiometry780
component stoichiometry: Stoichiometry773
component stoichiometry: Stoichiometry775
component: PhysicalEntity114
component: Protein713
component: PhysicalEntity108
component: Protein710
component: PhysicalEntity106
component: Protein704
component: Protein715
component: PhysicalEntity91
component: Protein721
component: PhysicalEntity96
component: PhysicalEntity116
component: PhysicalEntity92
component: PhysicalEntity121
component: Protein702
component: Protein727
component: PhysicalEntity94
component: Protein722
component: Protein724
component: PhysicalEntity117
xref: UnificationXref2286
cellular location: GO:0005654
comment: Reactome DB_ID: 3641306

UnificationXref2258
type: UnificationXref
id: 3641100
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641100

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXD2
data source: Provenance1
name: KIAA1073
name: Q1ZXD2
xref: UnificationXref7246
feature: FragmentFeature1505
cellular location: GO:0005829
comment: Reactome DB_ID: 3650062
display name: MTMR2

UnificationXref2259
type: UnificationXref
id: 3641008
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641008

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54C52
data source: Provenance1
name: Q54C52
name: KIAA1073
xref: UnificationXref7247
feature: FragmentFeature1506
cellular location: GO:0005829
comment: Reactome DB_ID: 3650063
display name: MTMR2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54YC2
data source: Provenance1
name: Q54YC2
name: KIAA1073
xref: UnificationXref7248
feature: FragmentFeature1507
cellular location: GO:0005829
comment: Reactome DB_ID: 3650064
display name: MTMR2

http://identifiers.org/pubmed/8089153
type: PublicationXref
id: 8089153
author: Hirst, M
author: Lou, L
author: Nakamura, J
author: Haliday, E
db: Pubmed
title: Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA
source: J Biol Chem 269:23830-23837
year: 1994

UnificationXref2241
type: UnificationXref
id: 3641067
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641067

UnificationXref2242
type: UnificationXref
id: 3641059
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641059

UnificationXref2240
type: UnificationXref
id: REACT_3989
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3989.1

RAD51:RAD52:DNA double strand break end complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry977
component stoichiometry: Stoichiometry976
component: Protein1113
component: Protein1114
xref: UnificationXref3976
cellular location: GO:0005654
comment: Reactome DB_ID: 3642742

http://identifiers.org/pubmed/10681536
type: PublicationXref
id: 10681536
author: Gaither, LA
author: Eide, DJ
db: Pubmed
title: Functional expression of the human hZIP2 zinc transporter
source: J Biol Chem 275:5560-4
year: 2000

RAD52:DNA double-strand break (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry974
component stoichiometry: Stoichiometry975
component: Protein1113
component: PhysicalEntity164
xref: UnificationXref3968
cellular location: GO:0005654
comment: Reactome DB_ID: 3642741

Q54GQ1
type: Protein
entity reference: Q54GQ1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7199
feature: FragmentFeature1497
cellular location: GO:0005829
comment: Reactome DB_ID: 3650148
display name: MTMR6

FEN1:PCNA complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry967
component stoichiometry: Stoichiometry966
component: Protein1105
component: Protein1106
xref: UnificationXref3906
cellular location: GO:0005654
comment: Reactome DB_ID: 3642912

Homologues of MTMR6
type: Protein
data source: Provenance1
member physical entity: Q54GQ1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7202
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3650150

UnificationXref2249
type: UnificationXref
id: 3641148
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641148

Pol zeta complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry969
component stoichiometry: Stoichiometry968
component: Protein1108
component: Protein1107
xref: UnificationXref3923
cellular location: GO:0005654
comment: Reactome DB_ID: 3642889

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q55E04
data source: Provenance1
name: Q55E04
xref: UnificationXref7196
feature: FragmentFeature1496
cellular location: GO:0005829
comment: Reactome DB_ID: 3650146
display name: MTMR1

UnificationXref2248
type: UnificationXref
id: 3641081
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641081

Pol zeta:damaged DNA template complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry971
component stoichiometry: Stoichiometry970
component: Pol zeta complex (name copied from entity in Homo sapiens)
component: PhysicalEntity160
xref: UnificationXref3924
cellular location: GO:0005654
comment: Reactome DB_ID: 3642890

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q55EE1
data source: Provenance1
name: Q55EE1
xref: UnificationXref7195
feature: FragmentFeature1495
cellular location: GO:0005829
comment: Reactome DB_ID: 3650145
display name: MTMR1

UnificationXref2247
type: UnificationXref
id: REACT_4072
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4072.1

RAD50:MRE11 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry972
component stoichiometry: Stoichiometry973
component: Protein1111
component: Protein1112
xref: UnificationXref3955
cellular location: GO:0005654
comment: Reactome DB_ID: 3642361

UnificationXref2246
type: UnificationXref
id: 72039
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72039

LIG3:XRRC1-bound DNA strand containing the ligated residue (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry959
component stoichiometry: Stoichiometry957
component stoichiometry: Stoichiometry958
component: Protein1101
component: LIG3:XRRC1 complex (name copied from entity in Homo sapiens)
component: PhysicalEntity157
xref: UnificationXref3880
cellular location: GO:0005654
comment: Reactome DB_ID: 3642070

UnificationXref2245
type: UnificationXref
id: 3641068
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641068

POL Beta: APE1-bound 5' incised DNA strand break containing first resynthesized base (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry961
component stoichiometry: Stoichiometry960
component: POL Beta: APE1-bound DNA strand break containing incision 5' to AP site (name copied from entity in Homo sapiens)
component: PhysicalEntity159
xref: UnificationXref3891
cellular location: GO:0005654
comment: Reactome DB_ID: 3642926

Metabolism
type: Pathway
data source: Provenance1
pathway component: REACT 156177.3
pathway component: REACT 161664.2
pathway component: REACT 90880.9
pathway component: REACT 29205.10
pathway component: REACT 114699.8
pathway component: REACT 28039.10
pathway component: REACT 32803.10
pathway component: REACT 158062.3
pathway component: REACT 84240.9
pathway component: REACT 131768.5
pathway component: REACT 77686.9
pathway component: REACT 29526.10
pathway component: REACT 139410.5
pathway component: REACT 98086.9
pathway component: REACT 33255.10
evidence: Evidence1492
xref: UnificationXref10389
xref: RelationshipXref1318
xref: UnificationXref10390
pathway order: PathwayStep1401
pathway order: PathwayStep1085
pathway order: PathwayStep1473
pathway order: PathwayStep1469
pathway order: PathwayStep1114
pathway order: PathwayStep1106
pathway order: PathwayStep1209
pathway order: PathwayStep1279
pathway order: PathwayStep1461
pathway order: PathwayStep1449
pathway order: PathwayStep1414
pathway order: PathwayStep1140
pathway order: PathwayStep1456
pathway order: PathwayStep801
pathway order: PathwayStep759
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref2244
type: UnificationXref
id: 3641063
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641063

APE1:DNA ligase I complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry962
component stoichiometry: Stoichiometry963
component: Protein1100
component: Protein1104
xref: UnificationXref3896
cellular location: GO:0005654
comment: Reactome DB_ID: 3642914

UnificationXref2243
type: UnificationXref
id: Q55FQ0
db: UniProt

APE1:FEN1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry964
component stoichiometry: Stoichiometry965
component: Protein1100
component: Protein1105
xref: UnificationXref3901
cellular location: GO:0005654
comment: Reactome DB_ID: 3642920

http://identifiers.org/pubmed/18367721
type: PublicationXref
id: 18367721
author: Skinner, SJ
author: Deleault, KM
author: Whitfield, ML
author: Brooks, SA
author: Gross, RH
author: Townley-Tilson, WH
author: Emmons, J
db: Pubmed
title: Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation
source: RNA 14:888-902
year: 2008

Homologues of MTMR2
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7251
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3650067

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B0G126
data source: Provenance1
name: 1-phosphatidylinositol-3-phosphate 5-kinase
name: PIKFYVE
name: FYV1_HUMAN
name: B0G126
name: KIAA0981
xref: UnificationXref7236
feature: FragmentFeature1502
cellular location: GO:0031901
comment: Reactome DB_ID: 3650193
display name: PIP5K3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0188326
data source: Provenance1
name: VAC14
name: DDB0188326
name: ArPIKfyve
name: TAX1BP2
name: VAC14_HUMAN
name: Protein VAC14 homolog
xref: UnificationXref7235
feature: FragmentFeature1501
cellular location: GO:0031901
comment: Reactome DB_ID: 3650194
display name: TRX

DDB0205575
type: Protein
entity reference: Ensembl:DDB0205575
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SAC3
name: Polyphosphoinositide phosphatase
name: FIG4_HUMAN
xref: UnificationXref7234
feature: FragmentFeature1500
cellular location: GO:0031901
comment: Reactome DB_ID: 3650192
display name: FIG4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0219484
data source: Provenance1
name: DDB0219484
name: C3orf29
xref: UnificationXref7204
feature: FragmentFeature1499
cellular location: GO:0005829
comment: Reactome DB_ID: 3650154
display name: MTMR14

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q55AZ2
data source: Provenance1
name: Q55AZ2
xref: UnificationXref7201
feature: FragmentFeature1498
cellular location: GO:0005829
comment: Reactome DB_ID: 3650149
display name: MTMR6

http://identifiers.org/pubmed/11425315
type: PublicationXref
id: 11425315
author: Peng, H
author: Liu, Q
author: Golde, DW
author: Vera, JC
db: Pubmed
title: The predicted ATP-binding domains in the hexose transporter GLUT1 critically affect transporter activity.
source: Biochemistry 40:7874-81
year: 2001

http://identifiers.org/pubmed/12782243
type: PublicationXref
id: 12782243
author: Prézeau, L
author: Galvez, T
author: Pin, JP
db: Pubmed
title: Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors
source: Pharmacol Ther 98:325-54
year: 2003

UnificationXref2230
type: UnificationXref
id: REACT_3970
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3970.1

UnificationXref2231
type: UnificationXref
id: 3641106
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641106

LIG3:XRCC1:POL Beta:DNA strand break containing replaced unligated residue (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry956
component stoichiometry: Stoichiometry955
component stoichiometry: Stoichiometry954
component: PhysicalEntity156
component: Protein1101
component: LIG3:XRRC1 complex (name copied from entity in Homo sapiens)
xref: UnificationXref3873
cellular location: GO:0005654
comment: Reactome DB_ID: 3642069

LIG3:XRCC1:POL Beta complex at site of base repair (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry953
component stoichiometry: Stoichiometry952
component: POL Beta-bound DNA strand break containing gap left by excised residue (name copied from entity in Homo sapiens)
component: LIG3:XRRC1 complex (name copied from entity in Homo sapiens)
xref: UnificationXref3865
cellular location: GO:0005654
comment: Reactome DB_ID: 3642074

LIG3:XRRC1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry951
component stoichiometry: Stoichiometry950
component: Protein1102
component: Protein1103
xref: UnificationXref3864
cellular location: GO:0005654
comment: Reactome DB_ID: 3642068

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54C52
data source: Provenance1
name: MTM1
name: Q54C52
xref: UnificationXref7182
feature: FragmentFeature1486
cellular location: GO:0005829
comment: Reactome DB_ID: 3650046
display name: CG2

UnificationXref2237
type: UnificationXref
id: 3641142
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641142

POL Beta: APE1-bound DNA strand break containing incision 5' to AP site (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry946
component stoichiometry: Stoichiometry947
component: APE1-bound DNA strand break containing an incision 5' to an AP site (name copied from entity in Homo sapiens)
component: Protein1101
xref: UnificationXref3847
cellular location: GO:0005654
comment: Reactome DB_ID: 3642906

Ensembl:DDB0231371
type: ProteinReference
xref: UnificationXref8922
organism: Dictyostelium discoideum

UnificationXref2236
type: UnificationXref
id: DDB0188064
db: Ensembl

POL Beta-bound DNA strand break containing gap left by excised residue (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry948
component stoichiometry: Stoichiometry949
component: Protein1101
component: PhysicalEntity155
xref: UnificationXref3855
cellular location: GO:0005654
comment: Reactome DB_ID: 3642073

Ensembl:DDB0231370
type: ProteinReference
xref: UnificationXref8920
organism: Dictyostelium discoideum

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q55EE1
data source: Provenance1
name: MTM1
name: Q55EE1
xref: UnificationXref7186
feature: FragmentFeature1488
cellular location: GO:0005829
comment: Reactome DB_ID: 3650054
display name: CG2

UnificationXref2239
type: UnificationXref
id: 71916
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71916

DNA containing an APE1-bound AP site (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry943
component stoichiometry: Stoichiometry942
component: Protein1100
component: PhysicalEntity148
xref: UnificationXref3831
cellular location: GO:0005654
comment: Reactome DB_ID: 3642899

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54YC2
data source: Provenance1
name: MTM1
name: Q54YC2
xref: UnificationXref7184
feature: FragmentFeature1487
cellular location: GO:0005829
comment: Reactome DB_ID: 3650050
display name: CG2

UnificationXref2238
type: UnificationXref
id: 3641006
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641006

APE1-bound DNA strand break containing an incision 5' to an AP site (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry944
component stoichiometry: Stoichiometry945
component: PhysicalEntity154
component: Protein1100
xref: UnificationXref3842
cellular location: GO:0005654
comment: Reactome DB_ID: 3642903

Ensembl:DDB0233076
type: ProteinReference
xref: UnificationXref8900
organism: Dictyostelium discoideum

UnificationXref2233
type: UnificationXref
id: 3641108
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641108

hNTH1 glycosylase:thymine glycol complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry938
component stoichiometry: Stoichiometry939
component: Protein1099
component: PhysicalEntity151
xref: UnificationXref3802
cellular location: GO:0005654
comment: Reactome DB_ID: 3642847

UnificationXref2232
type: UnificationXref
id: 3641083
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641083

DNA containing a hNTH1-bound apurinic/apyrimidinic site (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry940
component stoichiometry: Stoichiometry941
component: Protein1099
component: PhysicalEntity148
xref: UnificationXref3807
cellular location: GO:0005654
comment: Reactome DB_ID: 3642853

UnificationXref2235
type: UnificationXref
id: REACT_5767
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5767.1

UnificationXref2234
type: UnificationXref
id: 72046
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72046

hNTH1 glycosylase: foramidopyrimidine complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry937
component stoichiometry: Stoichiometry936
component: Protein1099
component: PhysicalEntity147
xref: UnificationXref3797
cellular location: GO:0005654
comment: Reactome DB_ID: 3642851

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54C52
data source: Provenance1
name: Q54C52
xref: UnificationXref7193
feature: FragmentFeature1493
cellular location: GO:0005829
comment: Reactome DB_ID: 3650143
display name: MTMR1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXD2
data source: Provenance1
name: Q1ZXD2
xref: UnificationXref7192
feature: FragmentFeature1492
cellular location: GO:0005829
comment: Reactome DB_ID: 3650142
display name: MTMR1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54YC2
data source: Provenance1
name: Q54YC2
xref: UnificationXref7194
feature: FragmentFeature1494
cellular location: GO:0005829
comment: Reactome DB_ID: 3650144
display name: MTMR1

Homologues of MTMR1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7197
cellular location: GO:0005829
comment: Reactome DB_ID: 3650147
comment: Converted from EntitySet in Reactome

Ensembl:DDB0230115
type: ProteinReference
xref: UnificationXref8985
organism: Dictyostelium discoideum

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q55E04
data source: Provenance1
name: MTM1
name: Q55E04
xref: UnificationXref7188
feature: FragmentFeature1489
cellular location: GO:0005829
comment: Reactome DB_ID: 3650058
display name: CG2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54TD5
data source: Provenance1
name: Q54TD5
xref: UnificationXref7191
feature: FragmentFeature1491
cellular location: GO:0005829
comment: Reactome DB_ID: 3650141
display name: MTMR1

http://identifiers.org/pubmed/22522127
type: PublicationXref
id: 22522127
author: Oakley, Aaron J
author: Brock, Joseph
author: Liu, D
author: Board, PG
author: Zhou, Huina
db: Pubmed
title: Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases
source: J. Mol. Biol. 420:190-203
year: 2012

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54PL3
data source: Provenance1
name: Q54PL3
xref: UnificationXref7190
feature: FragmentFeature1490
cellular location: GO:0005829
comment: Reactome DB_ID: 3650140
display name: MTMR1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0234213
data source: Provenance1
name: PIP5K1gamma
name: DDB0234213
xref: UnificationXref7145
feature: FragmentFeature1478
cellular location: GO:0005829
comment: Reactome DB_ID: 3650014
display name: PIP5K1C

http://identifiers.org/pubmed/17635743
type: PublicationXref
id: 17635743
author: Bluteau, D
author: Debili, N
author: Chang, Y
author: Vainchenker, W
db: Pubmed
title: From hematopoietic stem cells to platelets
source: J Thromb Haemost 5:318-27
year: 2007

Pyruvate
type: SmallMoleculeReference
name: Pyruvic acid
name: Pyroracemic acid
name: 2-Oxopropanoate
name: 2-Oxopropanoic acid
name: Pyruvate [ChEBI:32816]
xref: UnificationXref5265

DNA containing an hOGG1-bound apurinic/apyrimidinic site (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry931
component stoichiometry: Stoichiometry930
component: Protein1098
component: PhysicalEntity148
xref: UnificationXref3773
cellular location: GO:0005654
comment: Reactome DB_ID: 3642873

DNA containing an MYH-bound apurinic/apyrimidinic site (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry928
component stoichiometry: Stoichiometry929
component: Protein1097
component: PhysicalEntity148
xref: UnificationXref3770
cellular location: GO:0005654
comment: Reactome DB_ID: 3642877

hNTH1 glycosylase:dihydrouracil complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry934
component stoichiometry: Stoichiometry935
component: Protein1099
component: PhysicalEntity150
xref: UnificationXref3794
cellular location: GO:0005654
comment: Reactome DB_ID: 3642849

UniProt:Q55EZ6
type: ProteinReference
xref: UnificationXref82
organism: Dictyostelium discoideum

hNTH1 glycosylase:cytosine glycol complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry933
component stoichiometry: Stoichiometry932
component: PhysicalEntity149
component: Protein1099
xref: UnificationXref3789
cellular location: GO:0005654
comment: Reactome DB_ID: 3642845

UnificationXref2220
type: UnificationXref
id: 3641077
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641077

Ensembl:DDB0237522
type: ProteinReference
xref: UnificationXref9349
organism: Dictyostelium discoideum

http://identifiers.org/pubmed/17686774
type: PublicationXref
id: 17686774
author: Tamura, A
author: Wakabayashi, K
author: Nakagawa, H
author: Hoshijima, K
author: Ishikawa, T
author: Komada, M
author: Koshiba, S
db: Pubmed
title: Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein
source: J Biol Chem 282:27841-6
year: 2007

UnificationXref2224
type: UnificationXref
id: 3641078
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641078

UnificationXref2223
type: UnificationXref
id: REACT_2529
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2529.1

UnificationXref2222
type: UnificationXref
id: 72056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72056

GABAB receptor:GABA (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry916
component stoichiometry: Stoichiometry917
component: SmallMolecule337
component: GABAB receptor (name copied from entity in Homo sapiens)
xref: UnificationXref3712
cellular location: GO:0005886
comment: Reactome DB_ID: 3646209

UnificationXref2221
type: UnificationXref
id: 3641080
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641080

G-protein alpha (i): GTP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry918
component stoichiometry: Stoichiometry919
component: PhysicalEntity144
component: SmallMolecule11
xref: UnificationXref3724
cellular location: GO:0005886
comment: Reactome DB_ID: 3646221

SYNJ
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Protein1509
xref: UnificationXref7152
cellular location: GO:0005829
comment: Reactome DB_ID: 3650094
comment: Converted from EntitySet in Reactome

UnificationXref2228
type: UnificationXref
id: 3641095
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641095

G-protein alpha (i):GTP:Adenylate cyclase (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry921
component stoichiometry: Stoichiometry920
component: G-protein alpha (i): GTP (name copied from entity in Homo sapiens)
component: Adenylate cyclase (Mg2+ cofactor) (name copied from entity in Homo sapiens)
xref: UnificationXref3725
cellular location: GO:0005886
comment: Reactome DB_ID: 3646777

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q55GN6
data source: Provenance1
name: PIP5K1gamma
name: PIP5K1C
xref: UnificationXref7146
feature: FragmentFeature1479
cellular location: GO:0005829
comment: Reactome DB_ID: 3650015
display name: Q55GN6

UnificationXref2227
type: UnificationXref
id: REACT_4415
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4415.1

MYH glycosylase:adenine complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry923
component stoichiometry: Stoichiometry922
component: Protein1097
component: PhysicalEntity145
xref: UnificationXref3748
cellular location: GO:0005654
comment: Reactome DB_ID: 3642871

UnificationXref2226
type: UnificationXref
id: 72055
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72055

hOGG1 glycosylase:8-oxo guanine complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry924
component stoichiometry: Stoichiometry925
component: Protein1098
component: PhysicalEntity146
xref: UnificationXref3755
cellular location: GO:0005654
comment: Reactome DB_ID: 3642863

UnificationXref2225
type: UnificationXref
id: 3641101
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641101

hOGG1 glycosylase: formamidopyrimidine complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry927
component stoichiometry: Stoichiometry926
component: Protein1098
component: PhysicalEntity147
xref: UnificationXref3760
cellular location: GO:0005654
comment: Reactome DB_ID: 3642865

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54VR4
data source: Provenance1
name: PIP5K2B
name: PIP4K2B
xref: UnificationXref7167
feature: FragmentFeature1482
cellular location: GO:0005829
comment: Reactome DB_ID: 3650025
display name: Q54VR4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54VR4
data source: Provenance1
name: PIP5K2A
name: PIP4K2A
name: Q54VR4
xref: UnificationXref7165
feature: FragmentFeature1481
cellular location: GO:0005829
comment: Reactome DB_ID: 3650023
display name: PIP5K2

INPP5(2)
type: Protein
data source: Provenance1
member physical entity: Protein146
member physical entity: Protein1508
xref: UnificationXref7157
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3650134

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q8I7P4
data source: Provenance1
name: KIAA0348
name: Q8I7P4
xref: UnificationXref7151
feature: FragmentFeature1480
cellular location: GO:0005829
comment: Reactome DB_ID: 3650093
display name: SYNJ2

UnificationXref2229
type: UnificationXref
id: 72052
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72052

COPII (Coat Protein 2) Mediated Vesicle Transport
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1
evidence: Evidence2
xref: RelationshipXref1
xref: UnificationXref51
xref: UnificationXref52
pathway order: PathwayStep1
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q1ZXD2
data source: Provenance1
name: MTM1
name: Q1ZXD2
xref: UnificationXref7180
feature: FragmentFeature1485
cellular location: GO:0005829
comment: Reactome DB_ID: 3650042
display name: CG2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54TD5
data source: Provenance1
name: MTM1
name: Q54TD5
xref: UnificationXref7178
feature: FragmentFeature1484
cellular location: GO:0005829
comment: Reactome DB_ID: 3650038
display name: CG2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54PL3
data source: Provenance1
name: MTM1
name: Q54PL3
xref: UnificationXref7176
feature: FragmentFeature1483
cellular location: GO:0005829
comment: Reactome DB_ID: 3650034
display name: CG2

Homologues of MTM1
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7189
cellular location: GO:0005829
comment: Reactome DB_ID: 3650059
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P54676
data source: Provenance1
name: PIK3C3
name: PI3K class III Catalytic subunit
name: P54676
xref: UnificationXref7112
feature: FragmentFeature1470
cellular location: GO:0005829
comment: Reactome DB_ID: 3644284
display name: VPS34

UnificationXref4591
type: UnificationXref
id: 3643862
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643862

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: B0G126
data source: Provenance1
name: 1-phosphatidylinositol-3-phosphate 5-kinase
name: PIKFYVE
name: FYV1_HUMAN
name: B0G126
name: KIAA0981
xref: UnificationXref7123
feature: FragmentFeature1471
cellular location: GO:0000139
comment: Reactome DB_ID: 3650124
display name: PIP5K3

UnificationXref4592
type: UnificationXref
id: 3643863
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643863

UnificationXref4590
type: UnificationXref
id: 3643860
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643860

UnificationXref4595
type: UnificationXref
id: 3643879
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643879

UnificationXref4596
type: UnificationXref
id: REACT_157163
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157163.3

UnificationXref4593
type: UnificationXref
id: 3643864
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643864

UnificationXref4594
type: UnificationXref
id: REACT_156087
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156087.3

Homodimer of 4 aminobutyrate aminotransferase (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry913
component: Protein1046
xref: UnificationXref3610
cellular location: GO:0005759
comment: Reactome DB_ID: 3648536

ATP6V0C hexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry910
component: Protein1020
xref: UnificationXref3501
cellular location: GO:0010008
comment: Reactome DB_ID: 3642219

ATP6V0 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry909
component stoichiometry: Stoichiometry908
component stoichiometry: Stoichiometry911
component stoichiometry: Stoichiometry907
component stoichiometry: Stoichiometry906
component: PhysicalEntity142
component: Protein1011
component: ATP6V0C hexamer (name copied from entity in Homo sapiens)
component: Protein1017
component: Protein1016
xref: UnificationXref3502
cellular location: GO:0010008
comment: Reactome DB_ID: 3642229

ATP6V1G dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry900
component: Protein1003
xref: UnificationXref3476
cellular location: GO:0005829
comment: Reactome DB_ID: 3642268

GABAB receptor (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry915
component stoichiometry: Stoichiometry914
component: Protein1075
component: Protein1059
xref: UnificationXref3709
cellular location: GO:0005886
comment: Reactome DB_ID: 3646208

Ensembl:DDB0230054
type: ProteinReference
xref: UnificationXref9159
organism: Dictyostelium discoideum

UnificationXref2211
type: UnificationXref
id: 3641072
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641072

UnificationXref2210
type: UnificationXref
id: Q54NS6
db: UniProt

ABCG2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry891
component: Protein988
xref: UnificationXref3453
cellular location: GO:0005886
comment: Reactome DB_ID: 3648646

http://identifiers.org/pubmed/14521508
type: PublicationXref
id: 14521508
author: Fransson, A
author: Aspenstrom, P
author: Saras, J
db: Pubmed
title: Rho GTPases have diverse effects on the organization of the actin filament system
source: Biochem J 377:327-37
year: 2004

UnificationXref2213
type: UnificationXref
id: 3641126
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641126

UnificationXref2212
type: UnificationXref
id: 3641105
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641105

UnificationXref2215
type: UnificationXref
id: 3641129
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641129

ATP6V1B trimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry895
component: Protein998
xref: UnificationXref3466
cellular location: GO:0005829
comment: Reactome DB_ID: 3642241

http://identifiers.org/pubmed/19261609
type: PublicationXref
id: 19261609
author: Vitvitsky, V
author: Singh, S
author: Banerjee, R
author: Zhu, W
author: Chiku, T
author: Padovani, D
db: Pubmed
title: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia
source: J Biol Chem 284:11601-12
year: 2009

UnificationXref2214
type: UnificationXref
id: 3641128
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641128

ATP6V1A trimer (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry897
component: Protein1001
xref: UnificationXref3469
cellular location: GO:0005829
comment: Reactome DB_ID: 3642234

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0188326
data source: Provenance1
name: VAC14
name: DDB0188326
name: ArPIKfyve
name: TAX1BP2
name: VAC14_HUMAN
name: Protein VAC14 homolog
xref: UnificationXref7125
feature: FragmentFeature1472
cellular location: GO:0000139
comment: Reactome DB_ID: 3650123
display name: TRX

UnificationXref2217
type: UnificationXref
id: 3641009
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641009

V-ATPase (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry912
component stoichiometry: Stoichiometry905
component: ATP6V1 (name copied from entity in Homo sapiens)
component: ATP6V0 (name copied from entity in Homo sapiens)
xref: UnificationXref3503
cellular location: GO:0010008
comment: Reactome DB_ID: 3642274

UnificationXref2216
type: UnificationXref
id: DDB0233639
db: Ensembl

ATP6V1 (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry904
component stoichiometry: Stoichiometry894
component stoichiometry: Stoichiometry896
component stoichiometry: Stoichiometry898
component stoichiometry: Stoichiometry901
component stoichiometry: Stoichiometry903
component stoichiometry: Stoichiometry902
component stoichiometry: Stoichiometry899
component: Protein1006
component: Protein1002
component: ATP6V1B trimer (name copied from entity in Homo sapiens)
component: Protein1010
component: Protein1007
component: ATP6V1A trimer (name copied from entity in Homo sapiens)
component: Protein995
component: ATP6V1G dimer (name copied from entity in Homo sapiens)
xref: UnificationXref3485
cellular location: GO:0005829
comment: Reactome DB_ID: 3642273

Homologues of PIP5K1A
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7141
cellular location: GO:0005829
comment: Reactome DB_ID: 3650010
comment: Converted from EntitySet in Reactome

UnificationXref2219
type: UnificationXref
id: 3641147
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641147

DDB0205575
type: Protein
entity reference: Ensembl:DDB0205575
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: SAC3
name: Polyphosphoinositide phosphatase
name: FIG4_HUMAN
xref: UnificationXref7127
feature: FragmentFeature1473
cellular location: GO:0000139
comment: Reactome DB_ID: 3650122
display name: FIG4

UnificationXref2218
type: UnificationXref
id: 3641110
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3641110

UnificationXref4599
type: UnificationXref
id: 3643878
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643878

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q55GN6
data source: Provenance1
name: PI51A_HUMAN
name: PIP5K1A
name: Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
xref: UnificationXref7140
feature: FragmentFeature1475
cellular location: GO:0005829
comment: Reactome DB_ID: 3650009
display name: Q55GN6

UnificationXref4598
type: UnificationXref
id: Q54EV7
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0234213
data source: Provenance1
name: PI51A_HUMAN
name: DDB0234213
name: Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
xref: UnificationXref7138
feature: FragmentFeature1474
cellular location: GO:0005829
comment: Reactome DB_ID: 3650005
display name: PIP5K1A

UnificationXref4597
type: UnificationXref
id: 3643880
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643880

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0234213
data source: Provenance1
name: Phosphatidylinositol-4-phosphate 5-kinase type-1 beta
name: DDB0234213
name: PIP5K1B
name: PI51B_HUMAN
xref: UnificationXref7142
feature: FragmentFeature1476
cellular location: GO:0005829
comment: Reactome DB_ID: 3650011
display name: STM7

Homologues of PIP5K1B
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7144
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3650013

Homologues of PIP5K1C
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7147
cellular location: GO:0005829
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3650016

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q55GN6
data source: Provenance1
name: Phosphatidylinositol-4-phosphate 5-kinase type-1 beta
name: PIP5K1B
name: Q55GN6
name: PI51B_HUMAN
xref: UnificationXref7143
feature: FragmentFeature1477
cellular location: GO:0005829
comment: Reactome DB_ID: 3650012
display name: STM7

ChEBI:53023 (GlcNAc)2 (Man)6 (PP-Dol)1
type: SmallMoleculeReference
name: (GlcNAc)2 (Man)6 (PP-Dol)1
xref: UnificationXref12682

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P54677
data source: Provenance1
name: PIK4CB
name: P54677
xref: UnificationXref7092
feature: FragmentFeature1466
cellular location: GO:0005829
comment: Reactome DB_ID: 3650190
display name: PI4KB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P54677
data source: Provenance1
name: PIK4CB
name: P54677
xref: UnificationXref7096
feature: FragmentFeature1467
cellular location: GO:0000139
comment: Reactome DB_ID: 3650115
display name: PI4KB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0219574
data source: Provenance1
name: KIAA0851
name: DDB0219574
xref: UnificationXref7102
feature: FragmentFeature1468
cellular location: GO:0000139
comment: Reactome DB_ID: 3650173
display name: SACM1L

SequenceSite2981
type: SequenceSite
position status: EQUAL
sequence position: 293

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54S77
data source: Provenance1
name: PI3K class III regulatory subunit
name: PIK3R4(2-1358)
name: Q54S77
xref: UnificationXref7109
feature: FragmentFeature1469
cellular location: GO:0005829
comment: Reactome DB_ID: 3644288
display name: PIK3R4

SequenceSite2980
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref6800
type: UnificationXref
id: 3649713
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649713

http://identifiers.org/pubmed/8428657
type: PublicationXref
id: 8428657
author: Yang, DC
author: Donovan, D
author: Vogeli, G
author: Vilalta, A
author: Wood, L
db: Pubmed
title: Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase
source: Gene 123:181-6
year: 1993

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference221
data source: Provenance1
name: DDB0235270
name: PLA2G6
xref: UnificationXref7039
feature: FragmentFeature1462
cellular location: GO:0005743
comment: Reactome DB_ID: 3649663
display name: iPLA2

UnificationXref4588
type: UnificationXref
id: 3643855
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643855

UnificationXref6801
type: UnificationXref
id: 3649714
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649714

UniProt:Q55FJ5
type: ProteinReference
xref: UnificationXref1256
organism: Dictyostelium discoideum

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54DX7
data source: Provenance1
name: TAZ_HUMAN
name: Q54DX7
name: Tafazzin
xref: UnificationXref7048
feature: FragmentFeature1463
cellular location: GO:0005743
comment: Reactome DB_ID: 3649670
display name: TAZ

UnificationXref4589
type: UnificationXref
id: 3643857
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643857

UnificationXref6802
type: UnificationXref
id: 3649715
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649715

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54ZN9
data source: Provenance1
name: PIK4CA
name: Q54ZN9
name: PI4KA
xref: UnificationXref7078
feature: FragmentFeature1464
cellular location: GO:0005829
comment: Reactome DB_ID: 3650086
display name: PI4K

UnificationXref4586
type: UnificationXref
id: 3643853
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643853

UnificationXref6803
type: UnificationXref
id: 3649716
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649716

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0219574
data source: Provenance1
name: KIAA0851
name: DDB0219574
xref: UnificationXref7082
feature: FragmentFeature1465
cellular location: GO:0005789
comment: Reactome DB_ID: 3650176
display name: SACM1L

UnificationXref4587
type: UnificationXref
id: 3643854
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643854

UnificationXref6804
type: UnificationXref
id: 3649718
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3649718

SequenceSite2987
type: SequenceSite
position status: EQUAL
sequence position: 475

UnificationXref6805
type: UnificationXref
id: REACT_130731
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130731.5

http://identifiers.org/pubmed/9268380
type: PublicationXref
id: 9268380
author: Fattaey, A
author: Booher, RN
author: Holman, PS
db: Pubmed
title: Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity
source: J Biol Chem 272:22300-6
year: 1997

SequenceSite2986
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref6806
type: UnificationXref
id: 1500644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500644

SequenceSite2989
type: SequenceSite
position status: EQUAL
sequence position: 326

UnificationXref6807
type: UnificationXref
id: REACT_123472
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123472.1

SequenceSite2988
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref6808
type: UnificationXref
id: 1524083
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524083

SequenceSite2983
type: SequenceSite
position status: EQUAL
sequence position: 373

UnificationXref6809
type: UnificationXref
id: REACT_124336
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124336.1

SequenceSite2982
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2985
type: SequenceSite
position status: EQUAL
sequence position: 230

SequenceSite2984
type: SequenceSite
position status: EQUAL
sequence position: 2

Evidence1097
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12721307
xref: http://identifiers.org/pubmed/21944752
xref: http://identifiers.org/pubmed/21540551
comment: A flavin-dependent monooxygenase involved in ubiquinone/ubiquinol biosynthesis, COQ6 (Heeringa et al. 2011) catalyses the C5-hydroxylation of 3-decaprenyl-4-hydroxybenzoic acid (DHB) to 3,4-dihydroxy-5-decaprenylbenzoic acid (DHDB). COQ6 is a peripheral membrane protein that localizes to the matrix side of the inner mitochondrial membrane (Gin et al. 2003). This reaction involving COQ6 is inferred from the equivalent reaction in yeast (Ozeir et al. 2011, Gin et al. 2003).

Evidence1096
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15153069
xref: http://identifiers.org/pubmed/17916383
comment: 4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2) catalyses the combination of 4-hydroxybenzoic acid, aka para-hydroxybenzoic acid (PHB) with the polyisoprenoid tail all-trans-decaprenyl diphosphate (all-E-10PrP2) to form 3-decaprenyl-4-hydroxybenzoic acid (DHB) (Forsgren et a l. 2004, Tekle et al. 2008). This reaction is irreversible and occurs in the mitochondria.

Evidence1095
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16262699
xref: http://identifiers.org/pubmed/17916383
comment: The polyprenyl diphosphate synthase consists of a tetramer comprising two units of decaprenyl-diphosphate synthase subunit 1 (PDSS1) and two units of decaprenyl-diphosphate synthase subunit 2 (PDSS2). It catalyses the combination of 2-trans,6-trans-farnesyl diphosphate (FPP) with isopentenyl diphosphate (IPPP) to form the polyisoprenoid tail all-trans-decaprenyl diphosphate (all-E-10PrP2) (Saiki et al. 2005, Tekle et al. 2008).

Evidence1094
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12011104
xref: http://identifiers.org/pubmed/18216770
xref: http://identifiers.org/pubmed/18165232
comment: Sphingolipids are derivatives of long chain sphingoid bases such as sphingosine (trans-1,3-dihydroxy 2-amino-4-octadecene), an 18-carbon unsaturated amino alcohol which is the most abundant sphingoid base in mammals. Amide linkage of a fatty acid to sphingosine yields ceramides. Esterification of phosphocholine to ceramides yields sphingomyelin, and ceramide glycosylation yields glycosylceramides. Introduction of sialic acid residues yields gangliosides. These molecules appear to be essential components of cell membranes, and intermediates in the pathways of sphingolipid synthesis and breakdown modulate processes including apoptosis and T cell trafficking. While sphingolipids are abundant in a wide variety of foodstuffs, these dietary molecules are mostly degraded by the intestinal flora and intestinal enzymes. The body primarily depends on de novo synthesis for its sphingolipid supply (Hannun and Obeid 2008; Merrill 2002). De novo synthesis proceeds in four steps: the condensation of palmitoyl-CoA and serine to form 3-ketosphinganine, the reduction of 3-ketosphinganine to sphinganine, the acylation of sphinganine with a long-chain fatty acyl CoA to form dihydroceramide, and the desaturation of dihydroceramide to form ceramide. Other sphingolipids involved in signaling are derived from ceramide and its biosynthetic intermediates. These include sphinganine (dihydrosphingosine) 1-phosphate, phytoceramide, sphingosine, and sphingosine 1-phosphate. Sphingomyelin is synthesized in a single step in the membrane of the Golgi apparatus from ceramides generated in the endoplasmic reticulum (ER) membrane and transferred to the Golgi by CERT (ceramide transfer protein), an isoform of COL4A3BP that is associated with the ER membrane as a complex with PPM1L (protein phosphatase 1-like) and VAPA or VAPB (VAMP-associated proteins A or B). Sphingomyelin synthesis appears to be regulated primarily at the level of this transport process through the reversible phosphorylation of CERT …

SequenceSite2979
type: SequenceSite
position status: EQUAL
sequence position: 293

http://identifiers.org/pubmed/17222168
type: PublicationXref
id: 17222168
author: Agre, P
author: Frøkiaer, J
author: Nielsen, S
author: Kwon, TH
db: Pubmed
title: Regulation and dysregulation of aquaporins in water balance disorders
source: J Intern Med 261:53-64
year: 2007

Evidence1099
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9083049
comment: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) catalyses the C-methyltransferase conversion of 2-methoxy-6-decaprenyl-1,4-benzoquinol (MDMQ10H2) to 6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol (DMQ10H2). This reaction is inferred from the equivalent reaction in yeast (Barkovich et al. 1997).

Evidence1098
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10777520
comment: Mitochondrial COQ3 is an O-methyltransferase required in the reaction to convert 3,4-dihydroxy-5-decaprenylbenzoic acid (DHDB) to 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid (MHDB) (Jonassen & Clarke 2000).

UnificationXref4585
type: UnificationXref
id: 3643847
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643847

UnificationXref4584
type: UnificationXref
id: 3643846
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643846

UnificationXref4583
type: UnificationXref
id: 3643843
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643843

UnificationXref4582
type: UnificationXref
id: REACT_154629
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154629.3

(Glc)2 (GlcNAc)2 (Man)9 (PP-Dol)1
type: SmallMoleculeReference
name: ChEBI:53020 (Glc)2 (GlcNAc)2 (Man)9 (PP-Dol)1
xref: UnificationXref12717

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference219
data source: Provenance1
name: PLA2G6
name: DDB0235279
xref: UnificationXref7037
feature: FragmentFeature1460
cellular location: GO:0005743
comment: Reactome DB_ID: 3649655
display name: iPLA2

UnificationXref4581
type: UnificationXref
id: 3643871
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643871

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference218
data source: Provenance1
name: PLA2G6
name: DDB0235269
xref: UnificationXref7036
feature: FragmentFeature1459
cellular location: GO:0005743
comment: Reactome DB_ID: 3649651
display name: iPLA2

UnificationXref4580
type: UnificationXref
id: REACT_158101
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158101.3

ChEBI:53022 (GlcNAc)2 (Man)5 (PP-Dol)1
type: SmallMoleculeReference
name: (GlcNAc)2 (Man)5 (PP-Dol)1
xref: UnificationXref12663

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference220
data source: Provenance1
name: DDB0235280
name: PLA2G6
xref: UnificationXref7038
feature: FragmentFeature1461
cellular location: GO:0005743
comment: Reactome DB_ID: 3649659
display name: iPLA2

ChEBI:53014 N(6)-carboxymethyl-L-lysine
type: SmallMoleculeReference
name: N(6)-carboxymethyl-L-lysine
xref: UnificationXref1182

Inflammasomes
type: Pathway
data source: Provenance1
pathway component: REACT 134202.5
evidence: Evidence114
xref: UnificationXref1173
xref: UnificationXref1174
pathway order: PathwayStep109
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

Homologues of PLA2G6
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref7040
cellular location: GO:0005743
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3649664

UnificationXref4579
type: UnificationXref
id: 3643916
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643916

SequenceSite2970
type: SequenceSite
position status: EQUAL
sequence position: 1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: ProteinReference217
data source: Provenance1
name: PLA2G6
name: DDB0231758
xref: UnificationXref7035
feature: FragmentFeature1458
cellular location: GO:0005743
comment: Reactome DB_ID: 3649647
display name: iPLA2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7KWX2
data source: Provenance1
name: Phosphatidylglycerophosphate synthase 1
name: PGP synthase 1
name: Q7KWX2
name: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
xref: UnificationXref7016
feature: FragmentFeature1456
cellular location: GO:0005743
comment: Reactome DB_ID: 3649697
display name: PGS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q86IG3
data source: Provenance1
name: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 ecNumber3.1.3.27/ecNumber
name: Q86IG3
xref: UnificationXref7022
feature: FragmentFeature1457
cellular location: GO:0005743
comment: Reactome DB_ID: 3649814
display name: PTPMT1

Phospholipase D4
type: Protein
entity reference: Q54K50
data source: Provenance1
name: Q54K50
name: Note: the coordinates are copied over from Homo sapiens.
name: Choline phosphatase 4
xref: UnificationXref7002
feature: FragmentFeature1454
cellular location: GO:0005789
comment: Reactome DB_ID: 3649789
display name: PLD4

UnificationXref4575
type: UnificationXref
id: 3643915
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643915

(Glc)3 (GlcNAc)2 (Man)9 (PP-Dol)1
type: SmallMoleculeReference
name: ChEBI:53019 (Glc)3 (GlcNAc)2 (Man)9 (PP-Dol)1
xref: UnificationXref12724

Phospholipase D4
type: Protein
entity reference: Q54SA1
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Q54SA1
name: Choline phosphatase 4
xref: UnificationXref7003
feature: FragmentFeature1455
cellular location: GO:0005789
comment: Reactome DB_ID: 3649790
display name: PLD4

UnificationXref4576
type: UnificationXref
id: 3643895
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643895

UnificationXref4577
type: UnificationXref
id: 3643442
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643442

Homologues of PLD4
type: Protein
data source: Provenance1
member physical entity: Phospholipase D4
xref: UnificationXref7004
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3649791

UnificationXref4578
type: UnificationXref
id: 3643907
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643907

SequenceSite2978
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2977
type: SequenceSite
position status: EQUAL
sequence position: 293

SequenceSite2976
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/16469117
type: PublicationXref
id: 16469117
author: High, S
author: Miller, FW
author: Dobberstein, B
author: Römisch, K
db: Pubmed
title: Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages
source: Arthritis Res Ther 8:R39
year: 2006

SequenceSite2975
type: SequenceSite
position status: EQUAL
sequence position: 418

Evidence1090
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/17105727
xref: http://identifiers.org/pubmed/11489889
comment: Human glucosylceramidase 2 (GBA2) hydrolyses the glucosidic bond of glucocerebrosides to form ceramide at the plasma membrane (Matern et al. 2001, Boot et al. 2007).

SequenceSite2974
type: SequenceSite
position status: EQUAL
sequence position: 1

Evidence1091
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12885774
xref: http://identifiers.org/pubmed/15458386
comment: Membrane-bound ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) mediates the hydrolysis of sphingomyelin to ceramide and choline phosphate (Duan et al. 2003, Wu et al. 2005).

SequenceSite2973
type: SequenceSite
position status: EQUAL
sequence position: 615

Evidence1092
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16229686
xref: http://identifiers.org/pubmed/15845354
comment: Neutral ceramidase (ASAH2) is an enzyme localised to the plasma membrane that catalyses the hydrolysis of ceramide to sphingosine and free fatty acid (Hwang et al. 2005, Galadari et al. 2006).

SequenceSite2972
type: SequenceSite
position status: EQUAL
sequence position: 1

Evidence1093
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/20919643
comment: The steps involved in the synthesis of glycosphingolipids (sphingolipids with one or more sugars attached) are annotated here (Gault et al. 2010).

SequenceSite2971
type: SequenceSite
position status: EQUAL
sequence position: 503

Evidence1084
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12011104
xref: http://identifiers.org/pubmed/20919643
comment: The main steps involved in de novo sphingolipid synthesis are annotated here (Merrill 2002, Gault et al. 2010).

Evidence1083
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18558101
xref: http://identifiers.org/pubmed/11018465
comment: SGPL1 (sphingosine-1-phosphate lyase 1), associated with the endoplasmic reticulum membrane, catalyzes the cleavage of cytosolic sphingosine 1-phosphate to form phosphoethanolamine and hexadec-2-enal (Van Veldhoven et al. 2000; Fyrst and Saba 2008).

Evidence1086
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/5822067
comment: Beta-galactosidase can hydrolyse a galactose moeity from globosides to form cerebrosides. Here, lactosylceramide is hydrolysed to glucosylceramide (Asp et al. 1969).

http://identifiers.org/pubmed/17222174
type: PublicationXref
id: 17222174
author: Van Schaftingen, E
author: Linster, CL
db: Pubmed
title: Vitamin C: biosynthesis, recycling and degradation in mammals
source: FEBS J 274:1-22
year: 2007

Evidence1085
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1928092
xref: http://identifiers.org/pubmed/5822067
xref: http://identifiers.org/pubmed/1907800
comment: Gangliosides are glycosphingolipids in which oligosaccharide chains containing N-acetylneuraminic acid (NeuNAc) are attached to a ceramide. The prototypical ganglioside GM1 can be hydrolysed to the GM2 ganglioside by beta-galactosidase (GLB1), cleaving off the terminal galactose (Asp et al. 1969). Defects in GLB1 causes the lysosomal storage diseases GM1-gangliosidosis (Yoshida et al. 1991) and Morquio syndrome B (Oshima et al. 1991).

Evidence1088
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16595074
xref: http://identifiers.org/pubmed/7504405
xref: http://identifiers.org/pubmed/15003450
xref: http://identifiers.org/pubmed/3014515
comment: Alpha-galactosidase A (GLA) (Bishop et al. 1986) removes the terminal galactose residue from glycolipids or glycoproteins resulting in galactose and an alcohol. An example is the Fabry disease substrate globotriaosylceramide (Gb3Cer) which is hydrolysed to form galactose and lactosylceramide. GLA functions as a homodimer (Garman & Garboczi 2004) and defects in this enzyme lead to Fabry disease (FD) (MIM:301500), a rare X-linked sphingolipidosis disease where glycolipids such as GB3 accumulate in many tissues (Garman & Garboczi 2004, Eng et al. 1993). Multiple mutations in GLA can cause the disease symptoms of Fabry disease (Shabeer et al. 2006).

Evidence1087
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12662933
xref: http://identifiers.org/pubmed/2965147
xref: http://identifiers.org/pubmed/2971395
comment: There are two major forms of bHEX: hexosaminidase A and B. The A form is a trimer of the subunits alpha, beta A and beta B. The B form is a tetramer of 2 beta A and 2 beta B subunits (O'Dowd et al. 1988, Mahuran et al. 1988). Both are able to cleave GalNAc from globoside (a glycosphingolipid with more than one sugar attached as the side chain). Here, globoside is cleaved to form Gb3Cer (a globotriaosylceramide) (Mark et al. 2003).

SequenceSite2968
type: SequenceSite
position status: EQUAL
sequence position: 2

Evidence1089
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/1840600
xref: http://identifiers.org/pubmed/1718266
xref: http://identifiers.org/pubmed/19405096
xref: http://identifiers.org/pubmed/1740330
comment: Sphingomyelin phosphodiesterase (SMPD1), also called acid sphingomyelinase (ASM), is a lysosomal phosphodiesterase that hydrolyses sphingomyelin to ceramide and phosphocholine (Schuchman et al. 1991, Schuchman et al. 1992). Defects in SMPD1 are the cause of two types of Niemann-Pick disease. Type A (NPDA, Niemann-Pick disease classical infantile form) (MIM:257200) (Ferlinz et al. 1991) and type B (NPDB, Niemann-Pick disease visceral form) (MIM:607616) (Rodriguez-Pascau et al. 2009).

SequenceSite2969
type: SequenceSite
position status: EQUAL
sequence position: 732

UnificationXref4572
type: UnificationXref
id: 3643904
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643904

UnificationXref4571
type: UnificationXref
id: REACT_159210
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159210.3

UnificationXref4574
type: UnificationXref
id: REACT_132342
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132342.5

UnificationXref4573
type: UnificationXref
id: 3643905
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643905

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54SA1
data source: Provenance1
name: Phospholipase D3
name: Q54SA1
xref: UnificationXref7000
feature: FragmentFeature1453
cellular location: GO:0005789
comment: Reactome DB_ID: 3649787
display name: PLD3

Q54K50
type: Protein
entity reference: Q54K50
data source: Provenance1
name: Note: the coordinates are copied over from Homo sapiens.
name: Phospholipase D3
xref: UnificationXref6999
feature: FragmentFeature1452
cellular location: GO:0005789
comment: Reactome DB_ID: 3649783
display name: PLD3

Homologues of PLD3
type: Protein
data source: Provenance1
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q54K50
xref: UnificationXref7001
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3649788

UnificationXref4570
type: UnificationXref
id: 3643911
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643911

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Ensembl:DDB0304755
data source: Provenance1
name: Lysophosphatidylinositol acyltransferase
name: Lysophospholipid acyltransferase 7
name: MBOAT7
name: LPLAT 7
name: Membrane-bound O-acyltransferase domain-containing protein 7
name: DDB0304755
xref: UnificationXref6986
feature: FragmentFeature1451
cellular location: GO:0005789
comment: Reactome DB_ID: 3649621
display name: LPIAT

UnificationXref4566
type: UnificationXref
id: 3643889
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643889

UnificationXref4567
type: UnificationXref
id: REACT_154332
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154332.3

UnificationXref4564
type: UnificationXref
id: 3643856
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643856

CHPT1(2-406)
type: Protein
entity reference: UniProt:Q8T2Q6
data source: Provenance1
name: Q8T2Q6
name: Note: the coordinates are copied over from Homo sapiens.
name: Cholinephosphotransferase 1
name: Diacylglycerol cholinephosphotransferase 1
name: CHPT1
xref: UnificationXref6902
feature: FragmentFeature1447
cellular location: GO:0000139
comment: Reactome DB_ID: 3649720
display name: CPT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q9NCL8
data source: Provenance1
name: Phosphatidylinositol transfer protein beta isoform
name: PIPNB_HUMAN
name: Q9NCL8
xref: UnificationXref6913
feature: FragmentFeature1448
cellular location: GO:0005789
comment: Reactome DB_ID: 3649824
display name: PITPNB

UnificationXref4565
type: UnificationXref
id: 3643886
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643886

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q9NCL8
data source: Provenance1
name: Phosphatidylinositol transfer protein beta isoform
name: PIPNB_HUMAN
name: Q9NCL8
xref: UnificationXref6917
feature: FragmentFeature1449
cellular location: GO:0000139
comment: Reactome DB_ID: 3649748
display name: PITPNB

LPCAT
type: Protein
data source: Provenance1
member physical entity: Protein1689
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref6935
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3649609

LPSAT
type: Protein
data source: Provenance1
member physical entity: Protein1688
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref6961
cellular location: GO:0005789
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 3649633

UnificationXref4568
type: UnificationXref
id: 3643887
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643887

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q54P27
data source: Provenance1
name: PI synthase
name: CDP-diacylglycerol--inositol 3-phosphatidyltransferase
name: Q54P27
name: PtdIns synthase
name: Phosphatidylinositol synthase
xref: UnificationXref6975
feature: FragmentFeature1450
cellular location: GO:0005789
comment: Reactome DB_ID: 3649728
display name: CDIPT

UnificationXref4569
type: UnificationXref
id: 3643910
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643910

Evidence1081
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10947957
xref: http://identifiers.org/pubmed/10802064
xref: http://identifiers.org/pubmed/10751414
comment: SPHK1 and 2 (sphingosine kinases 1 and 2) catalyze the reaction of sphingosine and ATP to form sphingosine 1-phosphate and ADP. Both enzymes are found in the cytosol (although they are also present in membrane-associated forms). Both enzymes also catalyze the phosphorylation of sphinganine (dihydrosphingosine) (Liu et al. 2000; Nava et al. 2000; Pitson et al. 2000).

Evidence1082
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12815058
xref: http://identifiers.org/pubmed/12411432
comment: SGPP1 and 2 (sphingosine-1-phosphate phosphatase 1 and 2) enzymes associated with the endoplasmic reticulum membrane catalyze the hydrolysis of cytosolic sphingosine 1-phosphate to form sphingosine and orthophosphate (Johnson et al. 2003; Ogawa et al. 2003).

CDC6 association with the ORC:origin complex
type: Pathway
data source: Provenance1
pathway component: TemplateReaction6
pathway component: BiochemicalReaction121
evidence: Evidence223
xref: UnificationXref1894
xref: UnificationXref1895
pathway order: PathwayStep215
pathway order: PathwayStep214
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

Evidence1080
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/18558101
xref: http://identifiers.org/pubmed/11018465
comment: SGPL1 (sphingosine-1-phosphate lyase 1), associated with the endoplasmic reticulum membrane, catalyzes the cleavage of cytosolic sphinganine (dihydrosphingosine) 1-phosphate to form phosphoethanolamine and hexadecanal (Van Veldhoven et al. 2000; Fyrst and Saba 2008).

http://identifiers.org/pubmed/11264579
type: PublicationXref
id: 11264579
author: Hutson, SM
author: Conway, ME
author: Dunbar, J
author: Farber, GK
author: Yennawar, NH
db: Pubmed
title: The structure of human mitochondrial branched-chain aminotransferase.
source: Acta Crystallogr D Biol Crystallogr 57:506-15
year: 2001

UnificationXref8590
type: UnificationXref
id: REACT_3541
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3541.2

Evidence1079
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/12815058
xref: http://identifiers.org/pubmed/12411432
comment: SGPP1 and 2 (sphingosine-1-phosphate phosphatase 1 and 2) enzymes associated with the endoplasmic reticulum membrane catalyze the hydrolysis of cytosolic sphinganine 1-phosphate to form sphinganine (dihydrosphingosine) and orthophosphate (Johnson et al. 2003; Ogawa et al. 2003).

Evidence1078
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/16100120
xref: http://identifiers.org/pubmed/16793762
xref: http://identifiers.org/pubmed/18165233
comment: LASS (âlongevity assurance homologâ, also known as ceramide synthase, CerS) enzymes associated with the endoplasmic reticulum membrane catalyze the reaction of sphinganine (dihydrosphingosine) and a long-chain fatty acyl CoA such as stearyl-CoA to form a dihydroceramide and CoASH (Pewzner-Jung et al. 2006). Six human LASS genes have been identified; they differ in the identities of the fatty acyl CoAs that they use most efficiently as substrates (Lahiri and Futerman 2005; Laviad et al. 2008).

UnificationXref8592
type: UnificationXref
id: REACT_4471
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4471.2

Evidence1077
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10947957
xref: http://identifiers.org/pubmed/10802064
xref: http://identifiers.org/pubmed/10751414
comment: SPHK1 and 2 (sphingosine kinases 1 and 2) each catalyze the reaction of sphinganine (dihydrosphingosine) and ATP to form dihydrosphingosine 1-phosphate and ADP. Both enzymes are found in the cytosol (although they are also present in membrane-associated forms). Both enzymes also catalyze the phosphorylation of sphingosine (Liu et al. 2000; Nava et al. 2000; Pitson et al. 2000).

UnificationXref8591
type: UnificationXref
id: 110693
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110693

Evidence1076
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/11356846
comment: ACER3 (alkaline ceramidase 3) catalyzes the hydrolysis of phytoceramide to yield a free fatty acid (annotated here as stearate) and phytosphingosine. ACER3 mRNA is widely expressed in the body, although most abundant in placenta. Immunofluoresence studies of cultured cells over-expressing GFP-tagged protein suggest its localization to membranes of the endoplasmic reticulum (annotated here) and also the Golgi apparatus (Mao et al. 2001).

Evidence1075
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/10722674
xref: http://identifiers.org/pubmed/17023427
xref: http://identifiers.org/pubmed/11242114
xref: http://identifiers.org/pubmed/17331073
xref: http://identifiers.org/pubmed/9363775
comment: SPTLC (serine palmitoyltransferase) enzyme complexes associated with the endoplasmic reticulum membrane catalyze the reaction of palmitoyl-CoA and serine to form 3-ketosphinganine. SPTLC2 and SPTLC3 polypeptides exhibit enzyme activity when either is complexed with SPTLC1. SPTLC1 and 2 are abundant and widely expressed in human tissues, while SPTLC3 is expressed only in a smaller group of tissues and at variable levels. Results of studies in which siRNA was used to reduce levels of the three endogenous mRNAs differentially suggest that SPTLC2 and 3 both encode active serine palmitoyltransferases (Hornemann et al. 2006). Neither human nor mouse SPTLC1 has detectable enzyme activity, but the protein has an essential function, as mutations that disrupt it are associated with hereditary neuropathy (Dawkins et al. 2001). Studies of mouse and hamster proteins support the hypothesis that heterodimerization with SPTLC1 stabilizes SPTLC2 (or 3) and mediates its localization to the endoplasmic reticulum membrane (Hanada et al. 2000; Weiss and Stoffel 1997). Analyses of complexes extracted from human placenta, and of cultured human cells over-expressing various SPTLC constructs, suggest that these heterodimers may associate into larger complexes (Hanada et al. 2000; Weiss and Stoffel 1997; Hornemann et al. 2006, 2007).

Evidence1074
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15063729
comment: DEGS2 (sphingolipid C4-hydroxylase 2 / âdegenerative spermatocyte homolog 2â) enzyme associated with the cytosolic face of the endoplasmic reticulum catalyzes the hydroxylation of dihydroceramide to form phytoceramide (Mizutani et al. 2004). Sequence similarity to the bifunctional mouse DEGS2 enzyme suggests that human DEGS2 protein might also catalyze the C4-dehydrogenation of dihydroceramide, but this hypothesis has not been tested experimentally.

Evidence1073
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9188692
xref: http://identifiers.org/pubmed/11937514
xref: http://identifiers.org/pubmed/9312549
comment: DEGS1 (sphingolipid delta(4)-desaturase 1 / âdegenerative spermatocyte homolog 1â) enzyme associated with the cytosolic face of the endoplasmic reticulum catalyzes the desaturation of dihydroceramide to form ceramide (Cadena et al. 1997; Ternes et al. 2002). The stoichiometry and cofactor requirements of the reaction are inferred from those observed in studies of ceramide synthesis in vitro catalyzed by rat liver microsomes (Michel et al. 1997). DEGS1 may also catalyze the 4-hydroxylation of dihydroceramide to form 4-hydroxysphinganine, but with low efficiency.

Evidence1072
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15328338
comment: KDSR (3-ketodihydrosphingosine reductase) enzyme associated with the cytosolic face of the endoplasmic reticulum membrane catalyzes the reduction of 3-ketosphinganine by NADPH to form sphinganine (dihydrosphingosine) (Kihara and Igarashi 2004).

UnificationXref8598
type: UnificationXref
id: REACT_4564
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4564.1

UnificationXref8597
type: UnificationXref
id: 110731
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110731

DNA replication initiation
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction316
pathway component: BiochemicalReaction317
evidence: Evidence561
xref: UnificationXref4402
xref: UnificationXref4403
xref: RelationshipXref322
pathway order: PathwayStep546
pathway order: PathwayStep545
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref8599
type: UnificationXref
id: 110653
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110653

UnificationXref8594
type: UnificationXref
id: REACT_21808
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21808.1

UnificationXref4563
type: UnificationXref
id: REACT_159230
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159230.3

UnificationXref8593
type: UnificationXref
id: 482803
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=482803

UnificationXref4562
type: UnificationXref
id: 3643894
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643894

UnificationXref8596
type: UnificationXref
id: REACT_4926
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4926.1

UnificationXref4561
type: UnificationXref
id: 3643892
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643892

UnificationXref8595
type: UnificationXref
id: 110577
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110577

UnificationXref4560
type: UnificationXref
id: 3643891
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643891

UniProt:Q55FI1
type: ProteinReference
xref: UnificationXref3608
organism: Dictyostelium discoideum

UnificationXref4553
type: UnificationXref
id: 3651690
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651690

UnificationXref4554
type: UnificationXref
id: REACT_90985
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90985.9

http://identifiers.org/pubmed/8137809
type: PublicationXref
id: 8137809
author: Thöny, B
author: Huber, R
author: Heizmann, CW
author: Bürgisser, D
author: Nar, H
db: Pubmed
title: Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis
source: EMBO J 13:1255-62
year: 1994

UniProt:Q55FI3
type: ProteinReference
xref: UnificationXref13254
organism: Dictyostelium discoideum

UnificationXref4555
type: UnificationXref
id: 3643884
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643884

UnificationXref4556
type: UnificationXref
id: 3643885
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643885

UnificationXref4557
type: UnificationXref
id: REACT_154459
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154459.3

SequenceSite2992
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref4558
type: UnificationXref
id: 3643888
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643888

SequenceSite2991
type: SequenceSite
position status: EQUAL
sequence position: 326

UnificationXref4559
type: UnificationXref
id: 3643890
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3643890

SequenceSite2990
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2996
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/1400883
type: PublicationXref
id: 1400883
author: Larsen, PR
author: Kieffer, JD
author: Berry, MJ
author: Harney, JW
author: Warne, RL
author: Mandel, SJ
db: Pubmed
title: Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase
source: J Clin Endocrinol Metab 75:1133-9
year: 1992

SequenceSite2995
type: SequenceSite
position status: EQUAL
sequence position: 323

Evidence1070
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref1943
xref: http://identifiers.org/pubmed/10681399
xref: http://identifiers.org/pubmed/19244215
comment: The epoxidation of arachidonic acid by cytochrome P450s (CYPs) results in the formation of unique bioactive lipid mediators termed epoxyeicosatrienoic acids (EETs). Each double bond has been shown to be susceptible to oxidation, resulting in 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET. The majority of the EET biological activities are diminished by the hydrolysis to the corresponding dihydroxyeicosatrienoic acids (DHET) (Capdevila et al. 2000, Buczynski et al. 2009, Vance & Vance 2008).

SequenceSite2994
type: SequenceSite
position status: EQUAL
sequence position: 1

Evidence1071
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref1943
xref: http://identifiers.org/pubmed/19244215
comment: Eicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth muscle contraction and relaxation, and the release of gastric acid. Eicosanoids are synthesized in humans primarily from arachidonic acid (all-cis 5,8,11,14-eicosatetraenoic acid) that is released from membrane phospholipids. Once released, arachidonic acid is acted on by prostaglandin G/H synthases (PTGS, also known as cyclooxygenases (COX)) to form prostaglandins and thromboxanes, by arachidonate lipoxygenases (ALOX) to form leukotrienes, epoxygenases (cytochrome P450s and epoxide hydrolase) to form epoxides such as 15-eicosatetraenoic acids, and omega-hydrolases (cytochrome P450s) to form hydroxyeicosatetraenoic acids (Buczynski et al. 2009, Vance & Vance 2008). Levels of free arachidonic acid in the cell are normally very low so the rate of synthesis of eicosanoids is determined primarily by the activity of phospholipase A2, which mediates phospholipid cleavage to generate free arachidonic acid. The enzymes involved in arachidonic acid metabolism are typically constitutively expressed so the subset of these enzymes expressed by a cell determines the range of eicosanoids it can synthesize. Eicosanoids are unstable, undergoing conversion to inactive forms with half-times under physiological conditions of seconds or minutes. Many of these reactions appear to be spontaneous.

SequenceSite2993
type: SequenceSite
position status: EQUAL
sequence position: 326

SequenceSite2999
type: SequenceSite
position status: EQUAL
sequence position: 323

SequenceSite2998
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2997
type: SequenceSite
position status: EQUAL
sequence position: 323

Evidence1066
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/14660610
xref: http://identifiers.org/pubmed/12432928
xref: http://identifiers.org/pubmed/15258110
xref: http://identifiers.org/pubmed/15611369
xref: http://identifiers.org/pubmed/9618440
comment: Several cytochrome P450s (CYPs) convert arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). The CYPs and their references are as follows: CYP4A11 (Gainer et al. 2005, Powell 1998); CYP4F2 (Powell et al. 1998, Kikuta et al. 2002); CYP2U1 (Chuang et al. 2004); CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004).

http://identifiers.org/pubmed/2900981
type: PublicationXref
id: 2900981
author: Palsdottir, A
author: Jensson, O
author: Arnason, A
author: Thorsteinsson, L
author: Grubb, A
author: Abrahamson, M
author: Olafsson, I
db: Pubmed
title: Mutation in cystatin C gene causes hereditary brain haemorrhage
source: Lancet 2:603-4
year: 1988

Evidence1065
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/9435160
xref: http://identifiers.org/pubmed/14660610
xref: http://identifiers.org/pubmed/15258110
xref: http://identifiers.org/pubmed/15611369
comment: Several cytochrome P450s (CYPs) convert arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-HETE). The CYPs and their references are as follows: CYP2C8 (Bylund et al. 1998); CYP2C9 (Bylund et al. 1998); CYP2C19 (Bylund et al. 1998); CYP4A11 (Gainer et al. 2005); CYP2U1 (Chuang et al. 2004); CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004).

Evidence1068
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15258110
xref: http://identifiers.org/pubmed/8631948
comment: Several cytochrome P450s (CYPs) convert arachidonic acid to 5,6-epoxyeicosatrienoic acid (5,6-EET). The CYPs and their references are as follows: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2J2 (Wu et al. 1996).

Evidence1067
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref1943
xref: http://identifiers.org/pubmed/10681399
xref: http://identifiers.org/pubmed/19244215
comment: Similar to the lipoxygenases, cytochrome P450 (CYP) enzymes catalyse the hydroxylation and epoxygenation of arachidonic acid. However, whereas lipoxygenases use an active non-heme iron to abstract hydrogen directly from arachidonic acid, CYPs contain a heme-iron active site that oxidizes its substrate by a different mechanism. They hydroxylate arachidonic acid between C-5 and C-15 to produce lipoxygenase-like hydroxyeicosatetraenoic acids (HETEs) and add a hydroxyl moiety to the sp3-hybridized omega-carbons to form a unique class of HETEs. The transfer of oxygen to the unstable arachidonic acid intermediate terminates the reaction by forming HETE or epoxy-eicosatrienoic acid (EETs), respectively (Capdevila et al. 2000, Buczynski et al. 2009, Vance & Vance 2008).

Evidence1062
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/8576264
xref: http://identifiers.org/pubmed/10837478
comment: Prostaglandin reductase 1 (PTGR1) aka LTB4DH, a 15-oxoprostaglandin 13-reductase (Yokomizo et al. 1996), metabolises 15-oxo lipoxin A4 aka 15-keto-LXA4 (15k-LXA4) to produce 13,14-dihydro-15-keto-Lipoxin A4 (dhk-LXA4). This reaction has been inferred from a reaction in pig (Clish et al. 2000).

Evidence1061
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref1943
xref: http://identifiers.org/pubmed/19130894
xref: http://identifiers.org/pubmed/6311078
xref: http://identifiers.org/pubmed/19244215
xref: http://identifiers.org/pubmed/17623009
comment: Leukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attraction and activation of leukocytes. LTs were discovered in 1938 and were termed the "slow release substance" (SRS) until their structures were determined in 1979 and they were then renamed to leukotrienes. LTs are derived from arachidonic acid through action by arachidonate 5-lipoxygenase (ALOX5). Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are generated as products derived from leukotriene A4 (LTA4). Eoxins are generated from leukotrienes (LTs) and resemble cysteinyl leukotrienes but have a different three-dimensional structure (Murphy & Gijon 2007, Hammarstrom 1983, MA.Claesson 2009, Vance & Vance 2008, Buczynski et al. 2009).

Evidence1064
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/15258110
comment: Cytochrome P450s 1A1 (CYP1A1), 1A2 (CYP1A2), and 1B1 (CYP1B1) convert arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids (16-, 17-, and 18-HETEs) (Choudhary et al. 2004).

Evidence1063
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: PublicationXref1943
xref: http://identifiers.org/pubmed/16968948
xref: http://identifiers.org/pubmed/19244215
comment: Lipoxins A4 (LXA4) and B4 (LXB4), structurally characterized from human neutrophils incubated with 15-hydroperoxy-eicosatetraenoic acid (15-HpETE), each contain three hydroxyl moieties and a conjugated tetraene. The third hydroxyl of LXA4 is positioned at C-6, and of LXB4 at C-14. The action of arachidonate 5-lipoxygenase (ALOX5), in concert with an arachidonate 12-lipoxygenase (ALOX12) or arachidonate 15-lipoxygenase (ALOX15) activity, has been shown to produce lipoxins by three distinct pathways. Neutrophil ALOX5 can produce and secrete leukotriene A4 (LTA4) that is taken up by platelets, where it is acted upon by ALOX12 to form lipoxins. Likewise, ALOX15s can generate either 15-hydroperoxy-eicosatetraenoic acid (15-HpETE) or 15-hydro-eicosatetraenoic acid (15-HETE) that can be taken up by monocytes and neutrophils, where highly expressed ALOX5 uses it to generate lipoxins. Finally, aspirin acetylated prostaglandin G/H synthase 2 (PTGS2), rendered unable to synthesize prostaglandins, can act as a 15-lipoxygenase. This leads to the formation of 15R-HETE and culminates in creation of epi-lipoxins, which have altered stereochemistry at the C-15 hydroxyl but similar biological potency (Chiang et al. 2006, Buczynski et al. 2009, Vance & Vance 2008).

Acyl chain remodelling of PE
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction585
pathway component: BiochemicalReaction584
pathway component: BiochemicalReaction583
evidence: Evidence958
xref: UnificationXref6850
xref: UnificationXref6849
xref: RelationshipXref662
pathway order: PathwayStep938
pathway order: PathwayStep939
pathway order: PathwayStep937
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

UnificationXref4550
type: UnificationXref
id: REACT_96916
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96916.9

Evidence1069
type: Evidence
evidence code: EvidenceCodeVocabulary1
xref: http://identifiers.org/pubmed/7625847
xref: http://identifiers.org/pubmed/15258110
xref: http://identifiers.org/pubmed/8631948
xref: http://identifiers.org/pubmed/9866708
comment: Several cytochrome P450s (CYPs) convert arachidonic acid to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (8,9-, 11,12-, 14,15-EETs). The CYPs and their references are as follows: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2C8, CYP2C9 (Rifkind et al. 1995); CYP2C19 (Bylund et al. 1998, Rifkind et al. 1995); CYP2J2 (Wu et al. 1996).

UnificationXref4552
type: UnificationXref
id: REACT_89845
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89845.9

UnificationXref4551
type: UnificationXref
id: 3651700
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651700

SequenceSite2942
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2943
type: SequenceSite
position status: EQUAL
sequence position: 520

SequenceSite2944
type: SequenceSite
position status: EQUAL
sequence position: 1

http://identifiers.org/pubmed/18767960
type: PublicationXref
id: 18767960
author: Antonellis, A
author: Green, ED
db: Pubmed
title: The role of aminoacyl-tRNA synthetases in genetic diseases
source: Annu Rev Genomics Hum Genet 9:87-107
year: 2008

SequenceSite2945
type: SequenceSite
position status: EQUAL
sequence position: 520

Dictyostelium discoideum
type: BioSource
xref: UnificationXref2

SequenceSite2940
type: SequenceSite
position status: EQUAL
sequence position: 40

SequenceSite2941
type: SequenceSite
position status: EQUAL
sequence position: 493

UnificationXref4549
type: UnificationXref
id: 3651689
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651689

http://identifiers.org/pubmed/2995985
type: PublicationXref
id: 2995985
author: Evans, DR
author: Kelly, RE
author: Pastra-Landis, SC
author: Lee, L
db: Pubmed
title: Oligomeric structure of the multifunctional protein CAD that initiates pyrimidine biosynthesis in mammalian cells
source: Proc Natl Acad Sci USA 82:6802-6806
year: 1985

UnificationXref8579
type: UnificationXref
id: 110638
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110638

UnificationXref4548
type: UnificationXref
id: REACT_96081
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96081.9

UnificationXref4547
type: UnificationXref
id: 3651694
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651694

UnificationXref4546
type: UnificationXref
id: REACT_153362
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153362.3

http://identifiers.org/pubmed/6022858
type: PublicationXref
id: 6022858
author: Younathan, ES
author: Pynes, GD
db: Pubmed
title: Purification and some properties of inorganic pyrophosphatase from human erythrocytes
source: J Biol Chem 242:2119-23
year: 1967

UnificationXref4545
type: UnificationXref
id: 3652366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3652366

UnificationXref4544
type: UnificationXref
id: REACT_157536
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157536.3

UnificationXref4543
type: UnificationXref
id: 3651205
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651205

UnificationXref4542
type: UnificationXref
id: 3651204
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651204

UnificationXref8571
type: UnificationXref
id: REACT_21786
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21786.1

UnificationXref4540
type: UnificationXref
id: REACT_151483
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151483.1

UnificationXref8572
type: UnificationXref
id: P22887
db: UniProt

UnificationXref4541
type: UnificationXref
id: 3651203
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651203

UnificationXref8573
type: UnificationXref
id: 3647964
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647964

UnificationXref8574
type: UnificationXref
id: 3647965
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647965

UnificationXref8575
type: UnificationXref
id: 3647967
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647967

http://identifiers.org/pubmed/18201392
type: PublicationXref
id: 18201392
author: Clarke, LA
db: Pubmed
title: The mucopolysaccharidoses: a success of molecular medicine
source: Expert Rev Mol Med 10:e1
year: 2008

UnificationXref8576
type: UnificationXref
id: REACT_156291
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156291.3

UnificationXref8577
type: UnificationXref
id: 3647968
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3647968

Spliceosomal Intermediate C Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry808
component stoichiometry: Stoichiometry786
component stoichiometry: Stoichiometry795
component stoichiometry: Stoichiometry761
component stoichiometry: Stoichiometry799
component stoichiometry: Stoichiometry810
component stoichiometry: Stoichiometry805
component stoichiometry: Stoichiometry791
component stoichiometry: Stoichiometry793
component stoichiometry: Stoichiometry812
component stoichiometry: Stoichiometry785
component stoichiometry: Stoichiometry803
component stoichiometry: Stoichiometry757
component stoichiometry: Stoichiometry797
component stoichiometry: Stoichiometry763
component stoichiometry: Stoichiometry792
component stoichiometry: Stoichiometry804
component stoichiometry: Stoichiometry758
component stoichiometry: Stoichiometry788
component stoichiometry: Stoichiometry764
component stoichiometry: Stoichiometry802
component stoichiometry: Stoichiometry801
component stoichiometry: Stoichiometry790
component stoichiometry: Stoichiometry796
component stoichiometry: Stoichiometry798
component stoichiometry: Stoichiometry806
component stoichiometry: Stoichiometry811
component stoichiometry: Stoichiometry789
component stoichiometry: Stoichiometry794
component stoichiometry: Stoichiometry800
component stoichiometry: Stoichiometry807
component stoichiometry: Stoichiometry762
component stoichiometry: Stoichiometry760
component stoichiometry: Stoichiometry809
component stoichiometry: Stoichiometry759
component stoichiometry: Stoichiometry813
component stoichiometry: Stoichiometry787
component stoichiometry: Stoichiometry784
component: PhysicalEntity120
component: PhysicalEntity125
component: Protein718
component: PhysicalEntity86
component: hnRNP proteins (name copied from entity in Homo sapiens)
component: PhysicalEntity97
component: Protein708
component: PhysicalEntity101
component: Protein723
component: PhysicalEntity98
component: Cleavage and Polyadenylation Complex (name copied from entity in Homo sapiens)
component: Protein720
component: U5 snRNP (name copied from entity in Homo sapiens)
component: Protein706
component: U6 snRNP (name copied from entity in Homo sapiens)
component: Protein714
component: PhysicalEntity119
component: PhysicalEntity107
component: PhysicalEntity90
component: Protein728
component: Protein705
component: Protein689
component: PhysicalEntity115
component: Protein709
component: PhysicalEntity89
component: Protein731
component: PhysicalEntity99
component: Protein703
component: PhysicalEntity124
component: Protein719
component: PhysicalEntity87
component: capped, methylated pre-mRNA:CBC Complex (name copied from entity in Homo sapiens)
component: PhysicalEntity126
component: PhysicalEntity113
component: U2 snRNP (name copied from entity in Homo sapiens)
component: PhysicalEntity102
component: PhysicalEntity122
component: PhysicalEntity123
xref: UnificationXref2290
cellular location: GO:0005654

UnificationXref8578
type: UnificationXref
id: REACT_157010
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157010.3

U1 snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry730
component stoichiometry: Stoichiometry731
component stoichiometry: Stoichiometry732
component stoichiometry: Stoichiometry728
component stoichiometry: Stoichiometry729
component: PhysicalEntity111
component: snRNP Sm core complex (name copied from entity in Homo sapiens)
component: Protein716
component: PhysicalEntity110
component: Protein717
xref: UnificationXref2245
cellular location: GO:0005654
comment: Reactome DB_ID: 3641068

Calnexin/calreticulin cycle
type: Pathway
data source: Provenance1
pathway component: REACT 95071.9
pathway component: BiochemicalReaction1184
pathway component: BiochemicalReaction1185
pathway component: BiochemicalReaction1186
evidence: Evidence1892
xref: UnificationXref12875
xref: UnificationXref12874
pathway order: PathwayStep1848
pathway order: PathwayStep1857
pathway order: PathwayStep1849
pathway order: PathwayStep1850
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

RNA Polymerase II holoenzyme complex (unphosphorylated) (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry698
component stoichiometry: Stoichiometry697
component stoichiometry: Stoichiometry702
component stoichiometry: Stoichiometry692
component stoichiometry: Stoichiometry694
component stoichiometry: Stoichiometry701
component stoichiometry: Stoichiometry699
component stoichiometry: Stoichiometry695
component stoichiometry: Stoichiometry693
component stoichiometry: Stoichiometry691
component stoichiometry: Stoichiometry700
component stoichiometry: Stoichiometry696
component: Protein646
component: Protein639
component: Protein647
component: Protein636
component: Protein645
component: Protein644
component: Protein637
component: Protein643
component: Protein642
component: Protein707
component: Protein638
component: Protein640
xref: UnificationXref2205
cellular location: GO:0005654
comment: Reactome DB_ID: 3641000

RNA Polymerase II (unphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry690
component stoichiometry: Stoichiometry703
component: TFIIF (name copied from entity in Homo sapiens)
component: RNA Polymerase II holoenzyme complex (unphosphorylated) (name copied from entity in Homo sapiens)
xref: UnificationXref2206
cellular location: GO:0005654
comment: Reactome DB_ID: 3641001

SequenceSite2939
type: SequenceSite
position status: EQUAL
sequence position: 414

capped, methylated pre-mRNA:CBC Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry706
component stoichiometry: Stoichiometry704
component stoichiometry: Stoichiometry705
component: PhysicalEntity95
component: Cap Binding Complex (CBC) (name copied from entity in Homo sapiens)
component: RNA Polymerase II (unphosphorylated):TFIIF complex (name copied from entity in Homo sapiens)
xref: UnificationXref2209
cellular location: GO:0005654
comment: Reactome DB_ID: 3641002

Spliceosomal E Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry723
component stoichiometry: Stoichiometry746
component stoichiometry: Stoichiometry684
component stoichiometry: Stoichiometry721
component stoichiometry: Stoichiometry745
component stoichiometry: Stoichiometry688
component stoichiometry: Stoichiometry681
component stoichiometry: Stoichiometry733
component stoichiometry: Stoichiometry714
component stoichiometry: Stoichiometry717
component stoichiometry: Stoichiometry711
component stoichiometry: Stoichiometry749
component stoichiometry: Stoichiometry708
component stoichiometry: Stoichiometry680
component stoichiometry: Stoichiometry682
component stoichiometry: Stoichiometry718
component stoichiometry: Stoichiometry686
component stoichiometry: Stoichiometry741
component stoichiometry: Stoichiometry748
component stoichiometry: Stoichiometry710
component stoichiometry: Stoichiometry687
component stoichiometry: Stoichiometry735
component stoichiometry: Stoichiometry707
component stoichiometry: Stoichiometry712
component stoichiometry: Stoichiometry724
component stoichiometry: Stoichiometry726
component stoichiometry: Stoichiometry737
component stoichiometry: Stoichiometry689
component stoichiometry: Stoichiometry734
component stoichiometry: Stoichiometry685
component stoichiometry: Stoichiometry727
component stoichiometry: Stoichiometry709
component stoichiometry: Stoichiometry750
component stoichiometry: Stoichiometry738
component stoichiometry: Stoichiometry719
component stoichiometry: Stoichiometry742
component stoichiometry: Stoichiometry713
component stoichiometry: Stoichiometry722
component stoichiometry: Stoichiometry751
component stoichiometry: Stoichiometry743
component stoichiometry: Stoichiometry720
component stoichiometry: Stoichiometry715
component stoichiometry: Stoichiometry716
component stoichiometry: Stoichiometry736
component stoichiometry: Stoichiometry679
component stoichiometry: Stoichiometry747
component stoichiometry: Stoichiometry683
component stoichiometry: Stoichiometry740
component stoichiometry: Stoichiometry744
component stoichiometry: Stoichiometry725
component stoichiometry: Stoichiometry739
component: PhysicalEntity108
component: PhysicalEntity112
component: Protein718
component: PhysicalEntity97
component: PhysicalEntity100
component: PhysicalEntity96
component: PhysicalEntity116
component: PhysicalEntity101
component: Protein723
component: PhysicalEntity92
component: Protein702
component: Protein727
component: U1 snRNP (name copied from entity in Homo sapiens)
component: Protein720
component: Protein714
component: PhysicalEntity107
component: PhysicalEntity90
component: Protein713
component: Protein705
component: PhysicalEntity104
component: Protein709
component: Protein715
component: Protein721
component: PhysicalEntity99
component: PhysicalEntity121
component: Protein719
component: capped, methylated pre-mRNA:CBC Complex (name copied from entity in Homo sapiens)

SF3A (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry674
component stoichiometry: Stoichiometry672
component stoichiometry: Stoichiometry673
component: Protein699
component: Protein697
component: Protein698
xref: UnificationXref2182
cellular location: GO:0005654
comment: Reactome DB_ID: 3641173

SequenceSite2936
type: SequenceSite
position status: EQUAL
sequence position: 1

SF3B (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry665
component stoichiometry: Stoichiometry667
component stoichiometry: Stoichiometry666
component stoichiometry: Stoichiometry663
component stoichiometry: Stoichiometry664
component: Protein694
component: Protein690
component: Protein692
component: Protein693
component: Protein695
xref: UnificationXref2172
cellular location: GO:0005654
comment: Reactome DB_ID: 3641194

SequenceSite2935
type: SequenceSite
position status: EQUAL
sequence position: 414

DARPP-32 events
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction1042
pathway component: BiochemicalReaction92
evidence: Evidence1632
xref: UnificationXref11282
xref: UnificationXref11281
pathway order: PathwayStep1607
pathway order: PathwayStep141
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

U2 snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry676
component stoichiometry: Stoichiometry662
component stoichiometry: Stoichiometry661
component stoichiometry: Stoichiometry671
component stoichiometry: Stoichiometry670
component stoichiometry: Stoichiometry668
component stoichiometry: Stoichiometry675
component stoichiometry: Stoichiometry677
component stoichiometry: Stoichiometry669
component: SF3A (name copied from entity in Homo sapiens)
component: Protein700
component: Protein696
component: Protein690
component: snRNP Sm core complex (name copied from entity in Homo sapiens)
component: SF3B (name copied from entity in Homo sapiens)
component: Protein691
component: Protein701
component: PhysicalEntity88
xref: UnificationXref2187
cellular location: GO:0005654
comment: Reactome DB_ID: 3641203

SequenceSite2938
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8570
type: UnificationXref
id: 482625
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=482625

Spliceosomal A Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry753
component stoichiometry: Stoichiometry659
component stoichiometry: Stoichiometry678
component stoichiometry: Stoichiometry755
component stoichiometry: Stoichiometry660
component stoichiometry: Stoichiometry752
component stoichiometry: Stoichiometry754
component stoichiometry: Stoichiometry658
component: Protein689
component: PhysicalEntity86
component: Spliceosomal E Complex (name copied from entity in Homo sapiens)
component: PhysicalEntity87
component: U2 snRNP (name copied from entity in Homo sapiens)
component: PhysicalEntity122
component: Protein731
component: Protein728
xref: UnificationXref2282
cellular location: GO:0005654
comment: Reactome DB_ID: 3641222

SequenceSite2937
type: SequenceSite
position status: EQUAL
sequence position: 414

SequenceSite2933
type: SequenceSite
position status: EQUAL
sequence position: 414

SequenceSite2934
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2931
type: SequenceSite
position status: EQUAL
sequence position: 658

SequenceSite2932
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref4539
type: UnificationXref
id: 1638792
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1638792

SequenceSite2930
type: SequenceSite
position status: EQUAL
sequence position: 59

6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositols
type: SmallMoleculeReference
name: 6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol [ChEBI:53059]
name: 6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol
xref: UnificationXref12517

UnificationXref4536
type: UnificationXref
id: 3651196
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651196

(GlcN)1 (Ino(acyl)-P)1 (Man)2 (EtN)1 (P)1
type: SmallMoleculeReference
xref: UnificationXref12508

UnificationXref4535
type: UnificationXref
id: 3651194
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651194

UnificationXref4538
type: UnificationXref
id: GO:0000775
db: GENE ONTOLOGY

6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositols
type: SmallMoleculeReference
name: 6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol
name: 6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol [ChEBI:53056]
xref: UnificationXref12497

UnificationXref4537
type: UnificationXref
id: REACT_157431
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157431.3

UnificationXref4532
type: UnificationXref
id: DDB0304904
db: Ensembl

UnificationXref4531
type: UnificationXref
id: REACT_151476
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151476.1

UnificationXref4534
type: UnificationXref
id: 3651193
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651193

UnificationXref4533
type: UnificationXref
id: 3651192
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651192

UnificationXref8584
type: UnificationXref
id: REACT_2983
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2983.2

http://identifiers.org/pubmed/1335363
type: PublicationXref
id: 1335363
author: Birnbaumer, L
db: Pubmed
title: Receptor-to-effector signaling through G proteins: roles for beta gamma dimers as well as alpha subunits
source: Cell 71:1069-72
year: 1992

UnificationXref8585
type: UnificationXref
id: 110680
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110680

UnificationXref8582
type: UnificationXref
id: REACT_5595
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5595.2

UnificationXref8583
type: UnificationXref
id: 110652
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110652

UnificationXref4530
type: UnificationXref
id: 2485002
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2485002

UnificationXref8588
type: UnificationXref
id: REACT_3368
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3368.2

U6 snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry651
component stoichiometry: Stoichiometry647
component stoichiometry: Stoichiometry648
component stoichiometry: Stoichiometry650
component stoichiometry: Stoichiometry649
component: PhysicalEntity84
component: Protein684
component: snRNP Sm core complex (name copied from entity in Homo sapiens)
component: Protein688
component: Protein674
xref: UnificationXref2152
cellular location: GO:0005654
comment: Reactome DB_ID: 3641057

UnificationXref8589
type: UnificationXref
id: 110720
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110720

U4 snRNP:U6 snRNP complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry652
component stoichiometry: Stoichiometry656
component: U4 snRNP (name copied from entity in Homo sapiens)
component: U6 snRNP (name copied from entity in Homo sapiens)
xref: UnificationXref2155
cellular location: GO:0005654
comment: Reactome DB_ID: 3641058

UnificationXref8586
type: UnificationXref
id: REACT_4429
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4429.2

UnificationXref8587
type: UnificationXref
id: 110668
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110668

U4 snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry653
component stoichiometry: Stoichiometry654
component stoichiometry: Stoichiometry655
component: Protein688
component: PhysicalEntity85
component: Protein674
xref: UnificationXref2154
cellular location: GO:0005654
comment: Reactome DB_ID: 3641019

Spliceosomal B Complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry657
component stoichiometry: Stoichiometry646
component stoichiometry: Stoichiometry756
component: U4 snRNP:U6 snRNP complex (name copied from entity in Homo sapiens)
component: Spliceosomal A Complex (name copied from entity in Homo sapiens)
component: U5 snRNP (name copied from entity in Homo sapiens)
xref: UnificationXref2283
cellular location: GO:0005654
comment: Reactome DB_ID: 3641253

CPSF (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry626
component stoichiometry: Stoichiometry624
component stoichiometry: Stoichiometry623
component stoichiometry: Stoichiometry625
component: PhysicalEntity82
component: Protein670
component: Protein671
component: Protein669
xref: UnificationXref2111
cellular location: GO:0005654
comment: Reactome DB_ID: 3641266

snRNP Sm core complex (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry634
component stoichiometry: Stoichiometry635
component stoichiometry: Stoichiometry639
component stoichiometry: Stoichiometry638
component stoichiometry: Stoichiometry640
component stoichiometry: Stoichiometry637
component stoichiometry: Stoichiometry636
component: Protein681
component: Protein680
component: Protein678
component: Protein677
component: Protein682
component: Protein679
component: Protein683
xref: UnificationXref2139
cellular location: GO:0005654
comment: Reactome DB_ID: 3641056

SequenceSite2929
type: SequenceSite
position status: EQUAL
sequence position: 680

U5 snRNP (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry630
component stoichiometry: Stoichiometry628
component stoichiometry: Stoichiometry643
component stoichiometry: Stoichiometry633
component stoichiometry: Stoichiometry641
component stoichiometry: Stoichiometry631
component stoichiometry: Stoichiometry632
component stoichiometry: Stoichiometry642
component stoichiometry: Stoichiometry645
component stoichiometry: Stoichiometry644
component stoichiometry: Stoichiometry629
component: Protein675
component: Protein676
component: Protein673
component: Protein684
component: snRNP Sm core complex (name copied from entity in Homo sapiens)
component: Protein685
component: Protein672
component: Protein687
component: Protein686
component: Protein674
component: PhysicalEntity83
xref: UnificationXref2148
cellular location: GO:0005654
comment: Reactome DB_ID: 3641252

SequenceSite2928
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref8580
type: UnificationXref
id: REACT_5419
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5419.2

CF I (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry610
component stoichiometry: Stoichiometry613
component stoichiometry: Stoichiometry611
component stoichiometry: Stoichiometry612
component: PhysicalEntity78
component: Protein663
component: PhysicalEntity80
component: PhysicalEntity79
xref: UnificationXref2089
cellular location: GO:0005654
comment: Reactome DB_ID: 3641295

SequenceSite2927
type: SequenceSite
position status: EQUAL
sequence position: 424

UnificationXref8581
type: UnificationXref
id: 110732
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110732

SequenceSite2926
type: SequenceSite
position status: EQUAL
sequence position: 27

CstF (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry621
component stoichiometry: Stoichiometry619
component stoichiometry: Stoichiometry620
component: Protein667
component: Protein668
component: Protein666
xref: UnificationXref2102
cellular location: GO:0005654
comment: Reactome DB_ID: 3641279

SequenceSite2925
type: SequenceSite
position status: EQUAL
sequence position: 736

CF II (name copied from entity in Homo sapiens)
type: Complex
data source: Provenance1
component stoichiometry: Stoichiometry617
component stoichiometry: Stoichiometry616
component: Protein665
component: PhysicalEntity81
xref: UnificationXref2095
cellular location: GO:0005654
comment: Reactome DB_ID: 3641301

SequenceSite2924
type: SequenceSite
position status: EQUAL
sequence position: 2

SequenceSite2960
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2961
type: SequenceSite
position status: EQUAL
sequence position: 419

UnificationXref4529
type: UnificationXref
id: CHEBI:15346
db: ChEBI

SequenceSite2962
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref4528
type: UnificationXref
id: 3651188
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651188

SequenceSite2963
type: SequenceSite
position status: EQUAL
sequence position: 300

SequenceSite2964
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2965
type: SequenceSite
position status: EQUAL
sequence position: 417

Clathrin derived vesicle budding
type: Pathway
data source: Provenance1
pathway component: BiochemicalReaction11
pathway component: BiochemicalReaction12
pathway component: BiochemicalReaction10
evidence: Evidence17
xref: UnificationXref151
xref: UnificationXref150
pathway order: PathwayStep16
pathway order: PathwayStep15
pathway order: PathwayStep14
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: Dictyostelium discoideum

SequenceSite2966
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2967
type: SequenceSite
position status: EQUAL
sequence position: 574

UnificationXref4523
type: UnificationXref
id: 113560
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113560

UnificationXref4522
type: UnificationXref
id: 3651184
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651184

UnificationXref4521
type: UnificationXref
id: 3651183
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651183

UnificationXref4520
type: UnificationXref
id: 3651182
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651182

http://identifiers.org/pubmed/9305914
type: PublicationXref
id: 9305914
author: Ishimi, Y
db: Pubmed
title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
source: J Biol Chem 272:24508-13
year: 1997

UnificationXref8558
type: UnificationXref
id: 110090
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110090

UnificationXref4527
type: UnificationXref
id: 3651187
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651187

UnificationXref8557
type: UnificationXref
id: CHEBI:16174
db: ChEBI

UnificationXref4526
type: UnificationXref
id: 3651186
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651186

UnificationXref4525
type: UnificationXref
id: 3651185
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3651185

UnificationXref8559
type: UnificationXref
id: REACT_4457
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4457.2

UnificationXref4524
type: UnificationXref
id: REACT_3947
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3947.2

UnificationXref8553
type: UnificationXref
id: 3642949
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642949

UnificationXref8554
type: UnificationXref
id: 3642950
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642950

UnificationXref8555
type: UnificationXref
id: 3642961
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642961

UnificationXref8556
type: UnificationXref
id: REACT_135948
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135948.5

UnificationXref8550
type: UnificationXref
id: REACT_157637
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157637.3

UnificationXref8551
type: UnificationXref
id: 3642947
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642947

http://identifiers.org/pubmed/14638695
type: PublicationXref
id: 14638695
author: Lu, M
author: Haney, LB
author: Brugnera, E
author: Hengartner, MO
author: Tosello-Trampont, AC
author: Klingele, D
author: Ravichandran, KS
author: Kinchen, JM
author: Chen, Q
author: Grimsley, CM
db: Pubmed
title: Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration
source: J Biol Chem 279:6087-97
year: 2004

UnificationXref8552
type: UnificationXref
id: 3642948
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3642948

SequenceSite2958
type: SequenceSite
position status: EQUAL
sequence position: 1