MODEL9808533471
type: SBMLModel
parameter: 739651
parameter: 739621
parameter: 739631
parameter: 739601
rule: 739572
parameter: 739655
rule: 739548
parameter: 739675
parameter: 739645
parameter: 739685
parameter: 739580
parameter: 739606
rule: 739522
parameter: 739679
rule: 739516
units def: 517656
parameter: 739594
parameter: 739627
units def: 517717
compartment: 739513
units def: 517632
is described by: http://identifiers.org/pubmed/1185607
parameter: 739612
parameter: 739652
notes: This a model from the article: Reconstruction of the electrical activity of cardiac Purkinje fibres. McAllister RE, Noble D, Tsien RW. J Physiol. 1975; 251(1):1-59 1185607 , Abstract: 1. The electrical activity of Cardiac Purkinje fibres was reconstructed using a mathematical model of the membrane current. The individual components of ionic curent were described by equations which wee based as closely as possible on previous experiments using the voltage clamp technique. 2. Membrane action potentials and pace-maker activity were calculated and compared with time course of underlying changes in two functionally distinct outeard currents, iX1 and iK2. 3. The repolarization of the theoretical action potential is triggered by the onset of iX1, which becomes activated over the plateau range of potentials. iK2 also activates during the plateau but does not play a controlling role in the repolarization. Hwever, iK2 does govern the slow pace-maker depolarization through its subsequent deactivation at negative potentials. 4. The individual phases of the calculated action potential and their 'experimental' modifications were compared with published records. The upstroke is generated by a Hodgkin-Huxley type sodium conductance (gNa), and rises with a maximum rate of 478 V/sec, somewhat less than experimentally observed values ( up to 800 V/sec). The discrepancy is discussed in relation to experimental attempts at measuring gNa. 5. The ole of the transient outward chloride current (called igr) was studied in calculations of the rapid phase of repolarization and 'notch' configuration... This model was taken from the CellML repository and automatically converted to SBML. The original model was: McAllister, Noble, Tsien.(1975) - version05 The original CellML model was created by: Noble,Penny,J penny.noble@dpag.ox.ac.uk Department of Physiology, Anatomy & Genetics. University of Oxford This model originates from BioModels Database: A Database of Annotated Published Models (http://w…
parameter: 739636
parameter: 739718
rule: 739555
rule: 739545
rule: 739539
rule: 739551
parameter: 739585
parameter: 739595
rule: 739570
rule: 739558
rule: 739564
parameter: 739589
rule: 739554
parameter: 739681
parameter: 739622
parameter: 739586
rule: 739524
parameter: 739642
parameter: 739666
parameter: 739646
parameter: 739663
parameter: 739603
area units: area
parameter: 739667
parameter: 739619
parameter: 739582
units def: 517825
parameter: 739609
parameter: 739672
rule: 739537
rule: 739561
rule: 739531
rule: 739521
parameter: 739676
rule: 739515
parameter: 739591
rule: 739534
rule: 739540
rule: 739528
rule: 739518
parameter: 739658
rule: 739530
rule: 739519
parameter: 739613
parameter: 739577
parameter: 739682
parameter: 739597
parameter: 739657
parameter: 739637
parameter: 739628
parameter: 739643
rule: 739567
rule: 739557
rule: 739563

739651
type: Parameter
constant: false
units: 517789
value: NaN
name: I_x2

517789
type: SBMLUnitsDef
unit: 517813
unit: 517801
name: microA_per_cm2

517813
type: SBMLUnit
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE

517801
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: AMPERE

739621
type: Parameter
constant: false
units: dimensionless
value: NaN
name: d1

739631
type: Parameter
constant: false
units: 517607
value: NaN
name: alpha_s

517607
type: SBMLUnitsDef
unit: 517619
name: per_millisecond

517619
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND

739601
type: Parameter
constant: true
units: 517717
value: 0.8
name: g_si

517717
type: SBMLUnitsDef
unit: 517741
unit: 517729
name: milliS_per_cm2

517741
type: SBMLUnit
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE

517729
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: SIEMENS

739655
type: Parameter
constant: false
units: 517607
value: NaN
name: beta_x2

739675
type: Parameter
constant: false
units: 517607
value: NaN
name: beta_r

739645
type: Parameter
constant: false
units: 517607
value: NaN
name: beta_x1

739685
type: Parameter
constant: false
units: 517789
value: NaN
name: i_Cl_b

739580
type: Parameter
constant: false
units: 517789
value: NaN
name: i_Na

739606
type: Parameter
constant: false
units: dimensionless
value: 0.00293135
name: d

739679
type: Parameter
constant: false
units: 517789
value: NaN
name: i_K1

517656
type: SBMLUnitsDef
unit: 517669
name: per_millivolt

517669
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: VOLT

739594
type: Parameter
constant: false
units: 517607
value: NaN
name: alpha_h

739627
type: Parameter
constant: false
units: 517789
value: NaN
name: I_K2

739513
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

517632
type: SBMLUnitsDef
unit: 517644
name: millivolt

517644
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: VOLT

739612
type: Parameter
constant: true
units: 517583
value: NaN
name: time

517583
type: SBMLUnitsDef
unit: 517595
name: millisecond

517595
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND

739652
type: Parameter
constant: false
units: dimensionless
value: 0.0176854
name: x2

739636
type: Parameter
constant: true
units: 517632
value: NaN
name: V

739718
type: Parameter
constant: true
units: 517717
value: 0.01
name: g_Clb

739585
type: Parameter
constant: false
units: dimensionless
value: 0.02566853
name: m

739595
type: Parameter
constant: false
units: 517607
value: NaN
name: beta_h

739589
type: Parameter
constant: true
units: 517632
value: NaN
name: V

739681
type: Parameter
constant: true
units: 517632
value: -30.0
name: E_K1

739622
type: Parameter
constant: true
units: 517632
value: NaN
name: V

739586
type: Parameter
constant: false
units: 517607
value: NaN
name: alpha_m

739642
type: Parameter
constant: false
units: dimensionless
value: 0.02030289
name: x1

739666
type: Parameter
constant: false
units: 517607
value: NaN
name: alpha_q

739646
type: Parameter
constant: true
units: 517632
value: NaN
name: V

739663
type: Parameter
constant: true
units: 517717
value: 2.5
name: g_qr

739603
type: Parameter
constant: true
units: 517717
value: 0.04
name: g_si_

739667
type: Parameter
constant: false
units: 517607
value: NaN
name: beta_q

739619
type: Parameter
constant: true
units: 517583
value: NaN
name: time

739582
type: Parameter
constant: true
units: 517632
value: 40.0
name: E_Na

517825
type: SBMLUnitsDef
unit: 517849
unit: 517837
name: concentration_units

517849
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

517837
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

739609
type: Parameter
constant: false
units: 517607
value: NaN
name: beta_d

739672
type: Parameter
constant: false
units: dimensionless
value: 0.13500116
name: r

739676
type: Parameter
constant: true
units: 517632
value: NaN
name: V

739591
type: Parameter
constant: true
units: 517583
value: NaN
name: time

739658
type: Parameter
constant: true
units: 517583
value: NaN
name: time

739613
type: Parameter
constant: false
units: dimensionless
value: 0.80873917
name: f

739577
type: Parameter
constant: false
units: 517632
value: -78.041367
name: V

739682
type: Parameter
constant: false
units: 517789
value: NaN
name: i_Na_b

739597
type: Parameter
constant: true
units: 517632
value: NaN
name: V

739657
type: Parameter
constant: true
units: 517632
value: NaN
name: V

739637
type: Parameter
constant: true
units: 517583
value: NaN
name: time

739628
type: Parameter
constant: true
units: 517632
value: -110.0
name: E_K

739643
type: Parameter
constant: false
units: 517607
value: NaN
name: alpha_x1

517681
type: SBMLUnitsDef
unit: 517705
unit: 517693
name: per_millivolt_millisecond

517705
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND

517693
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: VOLT

739610
type: Parameter
constant: true
units: 517632
value: NaN
name: V

517862
type: SBMLUnitsDef
unit: 517874
name: time

517874
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND

739630
type: Parameter
constant: false
units: dimensionless
value: 0.75473994
name: s

739654
type: Parameter
constant: false
units: 517607
value: NaN
name: alpha_x2

739634
type: Parameter
constant: true
units: 517632
value: -52.0
name: E_s

739678
type: Parameter
constant: true
units: 517583
value: NaN
name: time

739633
type: Parameter
constant: false
units: 517607
value: NaN
name: beta_s

739673
type: Parameter
constant: false
units: 517607
value: NaN
name: alpha_r

739624
type: Parameter
constant: true
units: 517583
value: NaN
name: time

517753
type: SBMLUnitsDef
unit: 517777
unit: 517765
name: microF_per_cm2

517777
type: SBMLUnit
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE

517765
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: FARAD

739664
type: Parameter
constant: false
units: dimensionless
value: 3.11285794
name: q

739604
type: Parameter
constant: true
units: 517632
value: 70.0
name: E_si

739592
type: Parameter
constant: false
units: dimensionless
value: 0.78656359
name: h

739648
type: Parameter
constant: true
units: 517583
value: NaN
name: time

739615
type: Parameter
constant: false
units: 517607
value: NaN
name: alpha_f

739625
type: Parameter
constant: false
units: 517789
value: NaN
name: i_K2

739669
type: Parameter
constant: true
units: 517632
value: NaN
name: V

739639
type: Parameter
constant: false
units: 517789
value: NaN
name: i_x1

739649
type: Parameter
constant: false
units: 517789
value: NaN
name: i_x2

739607
type: Parameter
constant: false
units: 517607
value: NaN
name: alpha_d

739598
type: Parameter
constant: true
units: 517583
value: NaN
name: time

739670
type: Parameter
constant: true
units: 517583
value: NaN
name: time

739583
type: Parameter
constant: true
units: 517717
value: 150.0
name: g_Na

739616
type: Parameter
constant: false
units: 517607
value: NaN
name: beta_f

739660
type: Parameter
constant: false
units: 517789
value: NaN
name: i_qr

739600
type: Parameter
constant: false
units: 517789
value: NaN
name: i_si

739640
type: Parameter
constant: false
units: 517789
value: NaN
name: I_x1

739588
type: Parameter
constant: false
units: 517607
value: NaN
name: beta_m

739618
type: Parameter
constant: true
units: 517632
value: NaN
name: V

739684
type: Parameter
constant: true
units: 517717
value: 0.105
name: g_Nab

739661
type: Parameter
constant: true
units: 517632
value: -70.0
name: E_Cl

739579
type: Parameter
constant: true
units: 517753
value: 10.0
name: C