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notes: This model is taken from the Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51 This model shows kinetic binding of HomoArginine to neuronal nitric oxide synthase. Model shows the substrate (Homorginine) binding to nNOS in a two-step reversible fashion. First there is rapid binding equilibrium between Im-nNOS and Homoarginine to form an intermediate that contains bound imidazole and homoarginine. This is followed by a slower conformational change in the Im-enzyme-substrate complex that is associated with release of bound imidazole and generation of a modified enzyme-substrate complex which is detected due to spectral change. Rates approximated based on data in Table 2. The rates for first reaction are not exact since only Kd known and appropriate graphs do not exist for matching the profile. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
species: 011094
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species: 011074
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compartment: 011014
reaction: 011134
units def: 405421
substance units: 405469
is described by: http://identifiers.org/pubmed/10493814
compartment: 010994
species: 011114
volume units: 679943
time units: 131570
units def: 405385
name: Abu-Soud1999_HomoArginine
area units: area
curated: false
species: 011034

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constant: true
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011154
type: Reaction
kinetic law: 405577
product: 405565
reactant: 405553
reactant: 405541
notes: Binding of Homoarginine to Imidazole bound rat brain neuronal Nitric Oxide Synthase. Only Kd is known, Kf and Kb need to be approximated accordingly to match kinetic profiles. Due to lack of appropriate graphs the choice of Kf and Kb here is arbitrary and matches only the Kd. Kd = 10mM = 10000uM Abu-Soud HM et al. Biochemistry. 1999 21;38(38):12446-51
fast: false
reversible: true

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local parameters: 077458
local parameters: 077457
notes: kf*Homoarginine*Im_minus_nNOS-kb*Im_minus_nNOS_minus_Homoarginine

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value: 4.16666666666667E-13

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type: Reaction
kinetic law: 405529
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notes: Release of Imidazole from complex of Homoarginine and Imidazole bound rat brain neuronal Nitric Oxide Synthase. Abu-Soud HM et al. Biochemistry. 1999 21;38(38):12446-51
fast: false
reversible: true

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local parameters: 077456
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notes: kf*Im_minus_nNOS_minus_Homoarginine-kb*nNOS_minus_Homoarginine*Imidazole

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