MODEL9087766308
type: SBMLModel
length unit: length
volume units: 679943
notes: This model was taken from the Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. This model shows kinetic binding of L-Arginine to neuronal nitric oxide synthase. Model shows the substrate (L-Arginine) binding to nNOS in a two-step reversible fashion. First there is rapid binding equilibrium between Im-nNOS and L-Arginine to form an intermediate that contains bound imidazole and L-Arginine. This is followed by a slower conformational change in the Im-enzyme-substrate complex that is associated with release of bound imidazole and generation of a modified enzyme-substrate complex which is detected due to spectral change. Replicates Figure 4 panel) This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
units def: 398172
time units: 131570
area units: area
reaction: 999285
species: 999165
substance units: 398256
reaction: 999265
curated: false
species: 999185
name: Abu-Soud1999_L-Arginine
units def: 398256
species: 999205
compartment: 999130
compartment: 999145
species: 999245
units def: 398208
species: 999225
is described by: http://identifiers.org/pubmed/10493814

398196
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

398184
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

999285
type: Reaction
kinetic law: 398364
product: 398352
product: 398340
reactant: 398328
notes: Release of Imidazole from complex of L-Arginine and Imidazole bound rat brain neuronal Nitric Oxide Synthase. Abu-Soud HM et al. Biochemistry. 1999 21;38(38):12446-51.
fast: false
reversible: true

398364
type: KineticLaw
local parameters: 239862
local parameters: 239860
notes: kf*Im_minus_nNOS_minus_L_minus_Arginine-kb*nNOS_minus_L_minus_Arginine*Imidazole

239862
type: LocalParameter
units: 398208
value: 7.5E-19

398244
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

398232
type: SBMLUnit
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE

398220
type: SBMLUnit
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE

239860
type: LocalParameter
units: 398172
value: 1.35E-16

398352
type: SpeciesReference
stoichiometry: 1.0
species: 999245

999245
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 999145

999145
type: Compartment
constant: true
size: 1.6667E-18
spatial dimensions: 3.0

398340
type: SpeciesReference
stoichiometry: 1.0
species: 999225

999225
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 999145

398328
type: SpeciesReference
stoichiometry: 1.0
species: 999205

999205
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 999145

999165
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 999145

398268
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

999265
type: Reaction
kinetic law: 398316
product: 398304
reactant: 398292
reactant: 398280
notes: Binding of L-Arginine to Imidazole bound rat brain neuronal Nitric Oxide Synthase. Kd = 0.5mM = 500uM Abu-Soud HM et al. Biochemistry. 1999 21;38(38):12446-51.
fast: false
reversible: true

398316
type: KineticLaw
local parameters: 239858
local parameters: 239856
notes: kf*L_minus_Arginine*Im_minus_nNOS-kb*Im_minus_nNOS_minus_L_minus_Arginine

239858
type: LocalParameter
units: 398172
value: 2.08333333333333E-13

239856
type: LocalParameter
units: 398208
value: 4.16666666666667E-16

398304
type: SpeciesReference
stoichiometry: 1.0
species: 999205

398292
type: SpeciesReference
stoichiometry: 1.0
species: 999165

398280
type: SpeciesReference
stoichiometry: 1.0
species: 999185

999185
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6000.0
initial amount: NaN
in compartment: 999145

999130
type: Compartment
constant: true
size: 1.0E-18
spatial dimensions: 3.0