MODEL9087474843
type: SBMLModel
reaction: 743678
species: 742918
reaction: 748278
species: 742038
reaction: 745378
reaction: 743978
reaction: 747738
reaction: 744858
reaction: 749418
area units: area
species: 739079
species: 738059
reaction: 745678
reaction: 747878
species: 739999
species: 740779
reaction: 744498
species: 739259
reaction: 744458
species: 738879
species: 741619
reaction: 745238
species: 741559
species: 742118
species: 737679
species: 738139
reaction: 745038
species: 740419
species: 738559
reaction: 746598
species: 741978
reaction: 750618
reaction: 750698
species: 742758
species: 737859
species: 742818
reaction: 743858
species: 738819
reaction: 743898
reaction: 748758
reaction: 750418
units def: 371276
species: 741799
species: 740859
reaction: 746078
reaction: 750758
species: 742058
notes: This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
reaction: 746538
reaction: 748818
reaction: 746838
reaction: 748898
species: 740179
species: 738079
species: 739599
reaction: 750058
reaction: 749198
reaction: 746258
rule: 743318
species: 742998
reaction: 750398
rule: 743058
species: 739279
reaction: 746018
rule: 743098
reaction: 750118
reaction: 750198
species: 741639
species: 737759
species: 740119
species: 740439
reaction: 749138
species: 742138
reaction: 747378
reaction: 749738
reaction: 747098
species: 742838
species: 739919
reaction: 747558

743678
type: Reaction
kinetic law: 372011
product: 371999
reactant: 371987
reactant: 371975
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true

372011
type: KineticLaw
local parameters: 689360
local parameters: 689359
notes: kf*PP1_slash_I1_star_*PP1_minus_active-kb*PP1_slash_PP1_minus_I1_star_

689360
type: LocalParameter
units: 371312
value: 9.0E-18

371337
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

371325
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

689359
type: LocalParameter
units: 371397
value: 4.4998254E-14

371433
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

371421
type: SBMLUnit
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE

371409
type: SBMLUnit
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE

371999
type: SpeciesReference
stoichiometry: 1.0
species: 738019

738019
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

737339
type: Compartment
constant: true
size: 9.0E-17
spatial dimensions: 3.0

371987
type: SpeciesReference
stoichiometry: 1.0
species: 737419

737419
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 737339

371975
type: SpeciesReference
stoichiometry: 1.0
species: 737999

737999
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

742918
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

737359
type: Compartment
constant: true
size: 1.0E-17
spatial dimensions: 3.0

748278
type: Reaction
kinetic law: 383037
product: 383025
product: 383013
reactant: 383001
fast: false
reversible: false

383037
type: KineticLaw
local parameters: 689931
notes: k3*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx

689931
type: LocalParameter
units: 371312
value: 9.0E-16

383025
type: SpeciesReference
stoichiometry: 1.0
species: 740159

740159
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

383013
type: SpeciesReference
stoichiometry: 1.0
species: 740019

740019
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

383001
type: SpeciesReference
stoichiometry: 1.0
species: 740179

740179
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

742038
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

745378
type: Reaction
kinetic law: 376002
product: 375990
reactant: 375978
reactant: 375966
fast: false
reversible: true

376002
type: KineticLaw
local parameters: 689604
local parameters: 689602
notes: k1*AMPAR_slash_A845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx

689604
type: LocalParameter
units: 371312
value: 7.2E-16

689602
type: LocalParameter
units: 371397
value: 1.8106416E-16

375990
type: SpeciesReference
stoichiometry: 1.0
species: 738359

738359
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

375978
type: SpeciesReference
stoichiometry: 1.0
species: 738199

738199
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

375966
type: SpeciesReference
stoichiometry: 1.0
species: 741439

741439
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

743978
type: Reaction
kinetic law: 372748
product: 372735
reactant: 372723
notes: Represents diffusion, from a volume of 9e-20 to 5e-18. Assuming neck dimensions of 0.1 x 0.1 microns, this works out to a diffusion const of about 270 um^2/sec, which is pretty conservative. It is what cAMP does in frog cilia.
fast: false
reversible: true

372748
type: KineticLaw
local parameters: 689408
local parameters: 689407
notes: kf*cAMP-kb*AC_slash_cAMP_in_dend

689408
type: LocalParameter
units: 371312
value: 2.7E-14

689407
type: LocalParameter
units: 371312
value: 2.7E-14

372735
type: SpeciesReference
stoichiometry: 1.0
species: 740199

740199
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737379

737379
type: Compartment
constant: true
size: 5.0E-15
spatial dimensions: 3.0

372723
type: SpeciesReference
stoichiometry: 1.0
species: 737539

737539
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

747738
type: Reaction
kinetic law: 381721
product: 381708
reactant: 381696
reactant: 381684
fast: false
reversible: true

381721
type: KineticLaw
local parameters: 689869
local parameters: 689868
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx

689869
type: LocalParameter
units: 371312
value: 2.16E-15

689868
type: LocalParameter
units: 371397
value: 3.999888E-17

381708
type: SpeciesReference
stoichiometry: 1.0
species: 739779

739779
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

381696
type: SpeciesReference
stoichiometry: 1.0
species: 739239

739239
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

381684
type: SpeciesReference
stoichiometry: 1.0
species: 741559

741559
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

744858
type: Reaction
kinetic law: 374746
product: 374734
reactant: 374722
reactant: 374710
notes: See Hanson and Schulman again, for afterburst rates of phosph.
fast: false
reversible: true

374746
type: KineticLaw
local parameters: 689530
local parameters: 689528
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx

689530
type: LocalParameter
units: 371312
value: 2.16E-15

689528
type: LocalParameter
units: 371397
value: 7.714278E-18

374734
type: SpeciesReference
stoichiometry: 1.0
species: 737719

737719
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.90055555555556E-8
initial amount: NaN
in compartment: 737339

374722
type: SpeciesReference
stoichiometry: 1.0
species: 742618

742618
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737339

374710
type: SpeciesReference
stoichiometry: 1.0
species: 737659

737659
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

749418
type: Reaction
kinetic law: 385793
product: 385780
reactant: 385768
reactant: 385756
fast: false
reversible: true

385793
type: KineticLaw
local parameters: 690060
local parameters: 690058
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx

690060
type: LocalParameter
units: 371312
value: 1.4E-17

690058
type: LocalParameter
units: 371397
value: 8.7498E-18

385780
type: SpeciesReference
stoichiometry: 1.0
species: 740959

740959
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

385768
type: SpeciesReference
stoichiometry: 1.0
species: 740379

740379
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 737359

385756
type: SpeciesReference
stoichiometry: 1.0
species: 741839

741839
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

739079
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

738059
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.111111111111111
initial amount: NaN
in compartment: 737339

745678
type: Reaction
kinetic law: 376735
product: 376723
product: 376711
reactant: 376699
fast: false
reversible: false

376735
type: KineticLaw
local parameters: 689637
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx

689637
type: LocalParameter
units: 371312
value: 1.8E-16

376723
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376711
type: SpeciesReference
stoichiometry: 1.0
species: 741499

741499
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

376699
type: SpeciesReference
stoichiometry: 1.0
species: 738499

738499
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

747878
type: Reaction
kinetic law: 382062
product: 382050
product: 382038
reactant: 382026
fast: false
reversible: false

382062
type: KineticLaw
local parameters: 689884
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx

689884
type: LocalParameter
units: 371312
value: 5.4E-16

382050
type: SpeciesReference
stoichiometry: 1.0
species: 739239

382038
type: SpeciesReference
stoichiometry: 1.0
species: 741759

741759
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

382026
type: SpeciesReference
stoichiometry: 1.0
species: 739839

739839
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

739999
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 737339

740779
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

744498
type: Reaction
kinetic law: 373871
product: 373859
product: 373847
reactant: 373835
notes: Same as for back_1
fast: false
reversible: true

373871
type: KineticLaw
local parameters: 689486
local parameters: 689485
notes: kf*CaMKII_PSD_slash_CaMKII_minus_thr305_minus_PSD-kb*CaMKII_slash_CaMK_minus_thr305*CaMKII_PSD_slash_NMDAR

689486
type: LocalParameter
units: 371397
value: 5.4E-21

689485
type: LocalParameter
units: 371312
value: 3.0E-18

373859
type: SpeciesReference
stoichiometry: 1.0
species: 742398

742398
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120.0
initial amount: NaN
in compartment: 737359

373847
type: SpeciesReference
stoichiometry: 1.0
species: 737759

737759
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

373835
type: SpeciesReference
stoichiometry: 1.0
species: 741939

741939
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

739259
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

744458
type: Reaction
kinetic law: 373775
product: 373762
reactant: 373750
reactant: 373738
fast: false
reversible: true

373775
type: KineticLaw
local parameters: 689480
local parameters: 689479
notes: kf*CaMKII_PSD_slash_CaMKII_minus_PSD*CaM_minus_Ca4_minus_PSD-kb*CaMKII_PSD_slash_CaMKII_minus_CaM_minus_PSD

689480
type: LocalParameter
units: 371312
value: 0.0

689479
type: LocalParameter
units: 371397
value: 4.99998E-16

373762
type: SpeciesReference
stoichiometry: 1.0
species: 741979

741979
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

373750
type: SpeciesReference
stoichiometry: 1.0
species: 740259

740259
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

373738
type: SpeciesReference
stoichiometry: 1.0
species: 741959

741959
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

738879
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

741619
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

745238
type: Reaction
kinetic law: 375664
product: 375652
product: 375640
reactant: 375628
fast: false
reversible: false

375664
type: KineticLaw
local parameters: 689572
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx

689572
type: LocalParameter
units: 371312
value: 3.06E-17

375652
type: SpeciesReference
stoichiometry: 1.0
species: 738199

375640
type: SpeciesReference
stoichiometry: 1.0
species: 740299

740299
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 737359

375628
type: SpeciesReference
stoichiometry: 1.0
species: 738279

738279
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

742118
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 737359

737679
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6.3262962962963E-11
initial amount: NaN
in compartment: 737339

738139
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00127907407407407
initial amount: NaN
in compartment: 737339

745038
type: Reaction
kinetic law: 375182
product: 375169
product: 375156
reactant: 375144
fast: false
reversible: false

375182
type: KineticLaw
local parameters: 689549
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx

689549
type: LocalParameter
units: 371312
value: 1.8E-16

375169
type: SpeciesReference
stoichiometry: 1.0
species: 738059

375156
type: SpeciesReference
stoichiometry: 1.0
species: 740299

375144
type: SpeciesReference
stoichiometry: 1.0
species: 738119

738119
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.21555555555556E-7
initial amount: NaN
in compartment: 737339

740419
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

738559
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

746598
type: Reaction
kinetic law: 378962
product: 378950
product: 378938
reactant: 378926
fast: false
reversible: false

378962
type: KineticLaw
local parameters: 689740
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx

689740
type: LocalParameter
units: 371312
value: 6.03E-17

378950
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378938
type: SpeciesReference
stoichiometry: 1.0
species: 737899

737899
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 737359

378926
type: SpeciesReference
stoichiometry: 1.0
species: 738979

738979
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

741978
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

750618
type: Reaction
kinetic law: 388716
product: 388704
reactant: 388691
reactant: 388679
fast: false
reversible: true

388716
type: KineticLaw
local parameters: 690186
local parameters: 690184
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx

690186
type: LocalParameter
units: 371312
value: 2.0E-17

690184
type: LocalParameter
units: 371397
value: 2.77776E-19

388704
type: SpeciesReference
stoichiometry: 1.0
species: 742278

742278
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 737359

388691
type: SpeciesReference
stoichiometry: 1.0
species: 742978

742978
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737359

388679
type: SpeciesReference
stoichiometry: 1.0
species: 741699

741699
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

750698
type: Reaction
kinetic law: 388912
product: 388899
reactant: 388886
reactant: 388874
fast: false
reversible: true

388912
type: KineticLaw
local parameters: 690194
local parameters: 690192
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx

690194
type: LocalParameter
units: 371312
value: 2.0E-17

690192
type: LocalParameter
units: 371397
value: 2.77776E-19

388899
type: SpeciesReference
stoichiometry: 1.0
species: 742318

742318
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 737359

388886
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388874
type: SpeciesReference
stoichiometry: 1.0
species: 741799

741799
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

742758
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

737859
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 737359

742818
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

743858
type: Reaction
kinetic law: 372445
product: 372433
product: 372421
reactant: 372409
notes: This has to be fast, as the activation of PKA by cAMP is also fast. kf was 10
fast: false
reversible: true

372445
type: KineticLaw
local parameters: 689387
local parameters: 689386
notes: kf*PKA_slash_R2C2_minus_cAMP4-kb*PKA_slash_PKA_minus_active*PKA_slash_R2C_minus_cAMP4

689387
type: LocalParameter
units: 371397
value: 1.6199838E-15

689386
type: LocalParameter
units: 371312
value: 5.4E-15

372433
type: SpeciesReference
stoichiometry: 1.0
species: 739159

739159
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

372421
type: SpeciesReference
stoichiometry: 1.0
species: 739239

372409
type: SpeciesReference
stoichiometry: 1.0
species: 739139

739139
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

738819
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

743898
type: Reaction
kinetic law: 372542
product: 372530
reactant: 372518
reactant: 372506
notes: This has to be set to zero for matching the expts in vitro. In vivo we need to consider the inhibition though. kf = 1e-5 kb = 1
fast: false
reversible: true

372542
type: KineticLaw
local parameters: 689393
local parameters: 689392
notes: kf*PKA_slash_PKA_minus_active*PKA_slash_PKA_minus_inhibitor-kb*PKA_slash_inhibited_minus_PKA

689393
type: LocalParameter
units: 371312
value: 9.0E-17

689392
type: LocalParameter
units: 371397
value: 5.399946E-15

372530
type: SpeciesReference
stoichiometry: 1.0
species: 739219

739219
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

372518
type: SpeciesReference
stoichiometry: 1.0
species: 739199

739199
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.259259259259259
initial amount: NaN
in compartment: 737339

372506
type: SpeciesReference
stoichiometry: 1.0
species: 739239

748758
type: Reaction
kinetic law: 384200
product: 384188
product: 384176
reactant: 384164
fast: false
reversible: false

384200
type: KineticLaw
local parameters: 689985
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx

689985
type: LocalParameter
units: 371312
value: 3.5E-18

384188
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384176
type: SpeciesReference
stoichiometry: 1.0
species: 741539

741539
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

384164
type: SpeciesReference
stoichiometry: 1.0
species: 740619

740619
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

750418
type: Reaction
kinetic law: 388232
product: 388220
reactant: 388207
reactant: 388195
fast: false
reversible: true

388232
type: KineticLaw
local parameters: 690166
local parameters: 690164
notes: k1*AMPAR_memb_slash_A_B845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx

690166
type: LocalParameter
units: 371312
value: 2.0E-17

690164
type: LocalParameter
units: 371397
value: 2.77776E-19

388220
type: SpeciesReference
stoichiometry: 1.0
species: 742178

742178
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 737359

388207
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388195
type: SpeciesReference
stoichiometry: 1.0
species: 741679

741679
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

371300
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

371288
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

740859
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

746078
type: Reaction
kinetic law: 377703
product: 377691
product: 377678
reactant: 377666
fast: false
reversible: false

377703
type: KineticLaw
local parameters: 689682
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx

689682
type: LocalParameter
units: 371312
value: 1.8E-16

377691
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377678
type: SpeciesReference
stoichiometry: 1.0
species: 741539

377666
type: SpeciesReference
stoichiometry: 1.0
species: 738719

738719
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

750758
type: Reaction
kinetic law: 389057
product: 389045
product: 389033
reactant: 389021
fast: false
reversible: false

389057
type: KineticLaw
local parameters: 690199
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx

690199
type: LocalParameter
units: 371312
value: 5.0E-18

389045
type: SpeciesReference
stoichiometry: 1.0
species: 742978

389033
type: SpeciesReference
stoichiometry: 1.0
species: 741779

741779
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

389021
type: SpeciesReference
stoichiometry: 1.0
species: 742338

742338
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 737359

742058
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

746538
type: Reaction
kinetic law: 378817
product: 378805
reactant: 378793
reactant: 378781
fast: false
reversible: true

378817
type: KineticLaw
local parameters: 689734
local parameters: 689733
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx

689734
type: LocalParameter
units: 371312
value: 7.2E-16

689733
type: LocalParameter
units: 371397
value: 2.011824E-17

378805
type: SpeciesReference
stoichiometry: 1.0
species: 738959

738959
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

378793
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378781
type: SpeciesReference
stoichiometry: 1.0
species: 741779

748818
type: Reaction
kinetic law: 384345
product: 384333
reactant: 384321
reactant: 384309
fast: false
reversible: true

384345
type: KineticLaw
local parameters: 689992
local parameters: 689991
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx

689992
type: LocalParameter
units: 371312
value: 6.8E-18

689991
type: LocalParameter
units: 371397
value: 8.7498E-18

384333
type: SpeciesReference
stoichiometry: 1.0
species: 740659

740659
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

384321
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384309
type: SpeciesReference
stoichiometry: 1.0
species: 741819

741819
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

746838
type: Reaction
kinetic law: 379542
product: 379530
product: 379518
reactant: 379506
fast: false
reversible: false

379542
type: KineticLaw
local parameters: 689767
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx

689767
type: LocalParameter
units: 371312
value: 5.4E-16

379530
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379518
type: SpeciesReference
stoichiometry: 1.0
species: 741239

741239
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

379506
type: SpeciesReference
stoichiometry: 1.0
species: 739319

739319
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

748898
type: Reaction
kinetic law: 384537
product: 384525
reactant: 384513
reactant: 384501
fast: false
reversible: true

384537
type: KineticLaw
local parameters: 690001
local parameters: 690000
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx

690001
type: LocalParameter
units: 371312
value: 6.8E-18

690000
type: LocalParameter
units: 371397
value: 8.7498E-18

384525
type: SpeciesReference
stoichiometry: 1.0
species: 740699

740699
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

384513
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384501
type: SpeciesReference
stoichiometry: 1.0
species: 741699

738079
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.99333333333333E-6
initial amount: NaN
in compartment: 737339

739599
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

750058
type: Reaction
kinetic law: 387363
product: 387351
reactant: 387339
reactant: 387327
fast: false
reversible: true

387363
type: KineticLaw
local parameters: 690130
local parameters: 690128
notes: k1*CaMKII_PSD_slash_CaMKII_minus_PSD*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD-k2*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_act_autoph_slash_CaM_act_autoph_cplx

690130
type: LocalParameter
units: 371312
value: 8.0E-17

690128
type: LocalParameter
units: 371397
value: 3.12498E-19

387351
type: SpeciesReference
stoichiometry: 1.0
species: 742019

742019
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

387339
type: SpeciesReference
stoichiometry: 1.0
species: 742918

387327
type: SpeciesReference
stoichiometry: 1.0
species: 741959

749198
type: Reaction
kinetic law: 385263
product: 385251
product: 385239
reactant: 385227
fast: false
reversible: false

385263
type: KineticLaw
local parameters: 690034
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx

690034
type: LocalParameter
units: 371312
value: 3.5E-18

385251
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385239
type: SpeciesReference
stoichiometry: 1.0
species: 741619

385227
type: SpeciesReference
stoichiometry: 1.0
species: 740839

740839
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

746258
type: Reaction
kinetic law: 378140
product: 378128
reactant: 378116
reactant: 378104
fast: false
reversible: true

378140
type: KineticLaw
local parameters: 689703
local parameters: 689701
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx

689703
type: LocalParameter
units: 371312
value: 7.2E-16

689701
type: LocalParameter
units: 371397
value: 2.011824E-17

378128
type: SpeciesReference
stoichiometry: 1.0
species: 738819

378116
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378104
type: SpeciesReference
stoichiometry: 1.0
species: 741819

742998
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

750398
type: Reaction
kinetic law: 388183
product: 388171
product: 388159
reactant: 388147
fast: false
reversible: false

388183
type: KineticLaw
local parameters: 690163
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx

690163
type: LocalParameter
units: 371312
value: 5.0E-18

388171
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388159
type: SpeciesReference
stoichiometry: 1.0
species: 741819

388147
type: SpeciesReference
stoichiometry: 1.0
species: 742158

742158
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 737359

739279
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

746018
type: Reaction
kinetic law: 377557
product: 377545
reactant: 377533
reactant: 377520
fast: false
reversible: true

377557
type: KineticLaw
local parameters: 689676
local parameters: 689674
notes: k1*AMPAR_memb_slash_A_B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx

689676
type: LocalParameter
units: 371312
value: 7.2E-16

689674
type: LocalParameter
units: 371397
value: 2.011824E-17

377545
type: SpeciesReference
stoichiometry: 1.0
species: 738699

738699
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

377533
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377520
type: SpeciesReference
stoichiometry: 1.0
species: 741679

750118
type: Reaction
kinetic law: 387508
product: 387496
product: 387484
reactant: 387472
fast: false
reversible: false

387508
type: KineticLaw
local parameters: 690135
notes: k3*CaMKII_PSD_slash_tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx

690135
type: LocalParameter
units: 371312
value: 6.0E-17

387496
type: SpeciesReference
stoichiometry: 1.0
species: 742938

742938
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737359

387484
type: SpeciesReference
stoichiometry: 1.0
species: 741958

741958
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

387472
type: SpeciesReference
stoichiometry: 1.0
species: 742038

750198
type: Reaction
kinetic law: 387700
product: 387688
product: 387676
reactant: 387664
fast: false
reversible: false

387700
type: KineticLaw
local parameters: 690143
notes: k3*CaMKII_PSD_slash_tot_minus_auto_minus_PSD_slash_auton_minus_autoph_slash_auton_minus_autoph_cplx

690143
type: LocalParameter
units: 371312
value: 2.0E-17

387688
type: SpeciesReference
stoichiometry: 1.0
species: 742938

387676
type: SpeciesReference
stoichiometry: 1.0
species: 741978

387664
type: SpeciesReference
stoichiometry: 1.0
species: 742058

741639
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

740119
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.59259259259259
initial amount: NaN
in compartment: 737339

740439
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

749138
type: Reaction
kinetic law: 385119
product: 385106
reactant: 385094
reactant: 385081
fast: false
reversible: true

385119
type: KineticLaw
local parameters: 690028
local parameters: 690027
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx

690028
type: LocalParameter
units: 371312
value: 1.4E-17

690027
type: LocalParameter
units: 371397
value: 8.7498E-18

385106
type: SpeciesReference
stoichiometry: 1.0
species: 740819

740819
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

385094
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385081
type: SpeciesReference
stoichiometry: 1.0
species: 741819

742138
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 737359

747378
type: Reaction
kinetic law: 380851
product: 380839
reactant: 380827
reactant: 380815
fast: false
reversible: true

380851
type: KineticLaw
local parameters: 689829
local parameters: 689827
notes: k1*AMPAR_slash_A845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx

689829
type: LocalParameter
units: 371312
value: 2.16E-15

689827
type: LocalParameter
units: 371397
value: 3.5998992E-16

380839
type: SpeciesReference
stoichiometry: 1.0
species: 739599

380827
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380815
type: SpeciesReference
stoichiometry: 1.0
species: 741439

749738
type: Reaction
kinetic law: 386578
product: 386565
reactant: 386553
reactant: 386541
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

386578
type: KineticLaw
local parameters: 690096
local parameters: 690094
notes: k1*CaM_slash_neurogranin_minus_CaM_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx

690096
type: LocalParameter
units: 371312
value: 1.26E-16

690094
type: LocalParameter
units: 371397
value: 6.11982E-19

386565
type: SpeciesReference
stoichiometry: 1.0
species: 741139

741139
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

386553
type: SpeciesReference
stoichiometry: 1.0
species: 741039

741039
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 737339

386541
type: SpeciesReference
stoichiometry: 1.0
species: 737879

737879
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

747098
type: Reaction
kinetic law: 380174
product: 380162
reactant: 380150
reactant: 380138
fast: false
reversible: true

380174
type: KineticLaw
local parameters: 689797
local parameters: 689796
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx

689797
type: LocalParameter
units: 371312
value: 2.16E-15

689796
type: LocalParameter
units: 371397
value: 3.5998992E-16

380162
type: SpeciesReference
stoichiometry: 1.0
species: 739459

739459
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

380150
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380138
type: SpeciesReference
stoichiometry: 1.0
species: 741459

741459
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

742838
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

739919
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

747558
type: Reaction
kinetic law: 381286
product: 381274
product: 381262
reactant: 381250
fast: false
reversible: false

381286
type: KineticLaw
local parameters: 689848
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx

689848
type: LocalParameter
units: 371312
value: 5.4E-16

381274
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381262
type: SpeciesReference
stoichiometry: 1.0
species: 741619

381250
type: SpeciesReference
stoichiometry: 1.0
species: 739679

739679
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

743878
type: Reaction
kinetic law: 372494
product: 372482
product: 372469
reactant: 372457
fast: false
reversible: true

372494
type: KineticLaw
local parameters: 689390
local parameters: 689389
notes: kf*PKA_slash_R2C_minus_cAMP4-kb*PKA_slash_PKA_minus_active*PKA_slash_R2_minus_cAMP4

689390
type: LocalParameter
units: 371397
value: 1.6199838E-15

689389
type: LocalParameter
units: 371312
value: 5.4E-15

372482
type: SpeciesReference
stoichiometry: 1.0
species: 739179

739179
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

372469
type: SpeciesReference
stoichiometry: 1.0
species: 739239

372457
type: SpeciesReference
stoichiometry: 1.0
species: 739159

749878
type: Reaction
kinetic law: 386929
product: 386916
product: 386904
reactant: 386892
fast: false
reversible: false

386929
type: KineticLaw
local parameters: 690111
notes: k3*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

690111
type: LocalParameter
units: 371312
value: 2.0E-18

386916
type: SpeciesReference
stoichiometry: 1.0
species: 741859

741859
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737359

386904
type: SpeciesReference
stoichiometry: 1.0
species: 741978

386892
type: SpeciesReference
stoichiometry: 1.0
species: 741918

741918
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

749658
type: Reaction
kinetic law: 386385
product: 386373
reactant: 386361
reactant: 386349
notes: Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4
fast: false
reversible: true

386385
type: KineticLaw
local parameters: 690087
local parameters: 690085
notes: k1*AC_slash_AC2*PKC_minus_active-k2*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx

690087
type: LocalParameter
units: 371312
value: 1.44E-15

690085
type: LocalParameter
units: 371397
value: 5.399946E-17

386373
type: SpeciesReference
stoichiometry: 1.0
species: 741099

741099
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.00703703703704E-5
initial amount: NaN
in compartment: 737339

386361
type: SpeciesReference
stoichiometry: 1.0
species: 741039

386349
type: SpeciesReference
stoichiometry: 1.0
species: 739999

746758
type: Reaction
kinetic law: 379349
product: 379337
product: 379325
reactant: 379313
fast: false
reversible: false

379349
type: KineticLaw
local parameters: 689758
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx

689758
type: LocalParameter
units: 371312
value: 8.1E-16

379337
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379325
type: SpeciesReference
stoichiometry: 1.0
species: 737999

379313
type: SpeciesReference
stoichiometry: 1.0
species: 739279

740879
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

750818
type: Reaction
kinetic law: 389209
product: 389197
reactant: 389185
reactant: 389173
fast: false
reversible: true

389209
type: KineticLaw
local parameters: 690206
local parameters: 690205
notes: k1*AMPAR_memb_slash_A831_star__B*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx

690206
type: LocalParameter
units: 371312
value: 2.0E-17

690205
type: LocalParameter
units: 371397
value: 2.77776E-19

389197
type: SpeciesReference
stoichiometry: 1.0
species: 742378

742378
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 737359

389185
type: SpeciesReference
stoichiometry: 1.0
species: 742978

389173
type: SpeciesReference
stoichiometry: 1.0
species: 741559

747238
type: Reaction
kinetic law: 380512
product: 380500
product: 380488
reactant: 380475
fast: false
reversible: false

380512
type: KineticLaw
local parameters: 689812
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx

689812
type: LocalParameter
units: 371312
value: 5.4E-16

380500
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380488
type: SpeciesReference
stoichiometry: 1.0
species: 741339

741339
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

380475
type: SpeciesReference
stoichiometry: 1.0
species: 739519

739519
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

738899
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

738159
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 737339

747038
type: Reaction
kinetic law: 380029
product: 380017
product: 380005
reactant: 379993
fast: false
reversible: false

380029
type: KineticLaw
local parameters: 689790
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx

689790
type: LocalParameter
units: 371312
value: 5.4E-16

380017
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380005
type: SpeciesReference
stoichiometry: 1.0
species: 741499

379993
type: SpeciesReference
stoichiometry: 1.0
species: 739419

739419
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

746898
type: Reaction
kinetic law: 379689
product: 379676
reactant: 379664
reactant: 379651
fast: false
reversible: true

379689
type: KineticLaw
local parameters: 689775
local parameters: 689773
notes: k1*AMPAR_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx

689775
type: LocalParameter
units: 371312
value: 2.16E-15

689773
type: LocalParameter
units: 371397
value: 3.5998992E-16

379676
type: SpeciesReference
stoichiometry: 1.0
species: 739359

739359
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

379664
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379651
type: SpeciesReference
stoichiometry: 1.0
species: 741419

741419
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

746858
type: Reaction
kinetic law: 379590
product: 379578
reactant: 379566
reactant: 379554
fast: false
reversible: true

379590
type: KineticLaw
local parameters: 689770
local parameters: 689769
notes: k1*AMPAR_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx

689770
type: LocalParameter
units: 371312
value: 2.16E-15

689769
type: LocalParameter
units: 371397
value: 3.5998992E-16

379578
type: SpeciesReference
stoichiometry: 1.0
species: 739339

739339
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

379566
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379554
type: SpeciesReference
stoichiometry: 1.0
species: 741219

741219
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

748598
type: Reaction
kinetic law: 383814
product: 383802
product: 383789
reactant: 383777
fast: false
reversible: false

383814
type: KineticLaw
local parameters: 689967
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx

689967
type: LocalParameter
units: 371312
value: 1.7E-18

383802
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383789
type: SpeciesReference
stoichiometry: 1.0
species: 741559

383777
type: SpeciesReference
stoichiometry: 1.0
species: 740539

740539
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

744258
type: Reaction
kinetic law: 373350
product: 373338
reactant: 373326
reactant: 373314
fast: false
reversible: true

373350
type: KineticLaw
local parameters: 689450
local parameters: 689449
notes: kf*AMPAR_slash_A835_star_845_star__B835_star_845_star_*Anchor-kb*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_

689450
type: LocalParameter
units: 371312
value: 8.0E-20

689449
type: LocalParameter
units: 371397
value: 1.08E-19

373338
type: SpeciesReference
stoichiometry: 1.0
species: 741839

373326
type: SpeciesReference
stoichiometry: 1.0
species: 741519

741519
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 27.3333333333333
initial amount: NaN
in compartment: 737359

373314
type: SpeciesReference
stoichiometry: 1.0
species: 741359

741359
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

744218
type: Reaction
kinetic law: 373266
product: 373253
reactant: 373241
fast: false
reversible: true

373266
type: KineticLaw
local parameters: 689444
local parameters: 689443
notes: kf*AMPAR_slash_A831_star_845_star__B845_star_-kb*AMPAR_slash_AMPAR_deg

689444
type: LocalParameter
units: 371312
value: 0.0

689443
type: LocalParameter
units: 371312
value: 3.24E-21

373253
type: SpeciesReference
stoichiometry: 1.0
species: 742478

742478
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

373241
type: SpeciesReference
stoichiometry: 1.0
species: 741319

741319
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

748398
type: Reaction
kinetic law: 383329
product: 383317
product: 383305
reactant: 383293
fast: false
reversible: false

383329
type: KineticLaw
local parameters: 689944
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx

689944
type: LocalParameter
units: 371312
value: 1.7E-18

383317
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383305
type: SpeciesReference
stoichiometry: 1.0
species: 741539

383293
type: SpeciesReference
stoichiometry: 1.0
species: 740439

744058
type: Reaction
kinetic law: 372928
product: 372916
reactant: 372904
reactant: 372892
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true

372928
type: KineticLaw
local parameters: 689420
local parameters: 689419
notes: kf*CaM_minus_Ca3*Ca-kb*CaM_minus_Ca4

689420
type: LocalParameter
units: 371312
value: 9.0E-16

689419
type: LocalParameter
units: 371397
value: 4.1849946E-17

372916
type: SpeciesReference
stoichiometry: 1.0
species: 737399

737399
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

372904
type: SpeciesReference
stoichiometry: 1.0
species: 737559

737559
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 737339

372892
type: SpeciesReference
stoichiometry: 1.0
species: 737939

737939
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

749318
type: Reaction
kinetic law: 385551
product: 385539
product: 385527
reactant: 385515
fast: false
reversible: false

385551
type: KineticLaw
local parameters: 690048
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx

690048
type: LocalParameter
units: 371312
value: 3.5E-18

385539
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385527
type: SpeciesReference
stoichiometry: 1.0
species: 741759

385515
type: SpeciesReference
stoichiometry: 1.0
species: 740899

740899
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

746418
type: Reaction
kinetic law: 378526
product: 378514
reactant: 378502
reactant: 378490
fast: false
reversible: true

378526
type: KineticLaw
local parameters: 689721
local parameters: 689719
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx

689721
type: LocalParameter
units: 371312
value: 7.2E-16

689719
type: LocalParameter
units: 371397
value: 2.011824E-17

378514
type: SpeciesReference
stoichiometry: 1.0
species: 738899

378502
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378490
type: SpeciesReference
stoichiometry: 1.0
species: 741839

740139
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

743638
type: Reaction
kinetic law: 371927
product: 371915
reactant: 371903
reactant: 371891
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true

371927
type: KineticLaw
local parameters: 689354
local parameters: 689353
notes: kf*CaM_slash_neurogranin_PSD*CaM_slash_CaM_minus_PSD-kb*CaM_slash_neurogranin_minus_CaM_PSD

689354
type: LocalParameter
units: 371312
value: 1.0E-17

689353
type: LocalParameter
units: 371397
value: 3.0E-18

371915
type: SpeciesReference
stoichiometry: 1.0
species: 737879

371903
type: SpeciesReference
stoichiometry: 1.0
species: 737859

371891
type: SpeciesReference
stoichiometry: 1.0
species: 737899

748538
type: Reaction
kinetic law: 383668
product: 383656
reactant: 383644
reactant: 383632
fast: false
reversible: true

383668
type: KineticLaw
local parameters: 689961
local parameters: 689959
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx

689961
type: LocalParameter
units: 371312
value: 6.8E-18

689959
type: LocalParameter
units: 371397
value: 8.7498E-18

383656
type: SpeciesReference
stoichiometry: 1.0
species: 740519

740519
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

383644
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383632
type: SpeciesReference
stoichiometry: 1.0
species: 741739

741739
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

742078
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 737359

744938
type: Reaction
kinetic law: 374938
product: 374926
reactant: 374914
reactant: 374902
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true

374938
type: KineticLaw
local parameters: 689539
local parameters: 689537
notes: k1*PP1_slash_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx

689539
type: LocalParameter
units: 371312
value: 7.50006E-16

689537
type: LocalParameter
units: 371397
value: 5.81256E-17

374926
type: SpeciesReference
stoichiometry: 1.0
species: 738079

374914
type: SpeciesReference
stoichiometry: 1.0
species: 738059

374902
type: SpeciesReference
stoichiometry: 1.0
species: 737999

749718
type: Reaction
kinetic law: 386529
product: 386517
product: 386505
reactant: 386493
fast: false
reversible: false

386529
type: KineticLaw
local parameters: 690093
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx

690093
type: LocalParameter
units: 371312
value: 5.22E-17

386517
type: SpeciesReference
stoichiometry: 1.0
species: 741039

386505
type: SpeciesReference
stoichiometry: 1.0
species: 737919

737919
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

386493
type: SpeciesReference
stoichiometry: 1.0
species: 741119

741119
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

747778
type: Reaction
kinetic law: 381817
product: 381805
reactant: 381793
reactant: 381781
fast: false
reversible: true

381817
type: KineticLaw
local parameters: 689874
local parameters: 689872
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx

689874
type: LocalParameter
units: 371312
value: 2.16E-15

689872
type: LocalParameter
units: 371397
value: 3.999888E-17

381805
type: SpeciesReference
stoichiometry: 1.0
species: 739799

739799
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

381793
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381781
type: SpeciesReference
stoichiometry: 1.0
species: 741759

749458
type: Reaction
kinetic law: 385891
product: 385879
reactant: 385867
reactant: 385855
fast: false
reversible: true

385891
type: KineticLaw
local parameters: 690064
local parameters: 690063
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx

690064
type: LocalParameter
units: 371312
value: 1.4E-17

690063
type: LocalParameter
units: 371397
value: 8.7498E-18

385879
type: SpeciesReference
stoichiometry: 1.0
species: 740979

740979
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

385867
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385855
type: SpeciesReference
stoichiometry: 1.0
species: 741779

744978
type: Reaction
kinetic law: 375036
product: 375024
reactant: 375012
reactant: 374999
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true

375036
type: KineticLaw
local parameters: 689543
local parameters: 689542
notes: k1*PP1_slash_PP1_minus_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx

689543
type: LocalParameter
units: 371312
value: 7.50006E-16

689542
type: LocalParameter
units: 371397
value: 5.81256E-17

375024
type: SpeciesReference
stoichiometry: 1.0
species: 738099

738099
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00691
initial amount: NaN
in compartment: 737339

375012
type: SpeciesReference
stoichiometry: 1.0
species: 738059

374999
type: SpeciesReference
stoichiometry: 1.0
species: 738019

745098
type: Reaction
kinetic law: 375328
product: 375315
reactant: 375303
reactant: 375291
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true

375328
type: KineticLaw
local parameters: 689557
local parameters: 689555
notes: k1*CaM_slash_neurogranin_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx

689557
type: LocalParameter
units: 371312
value: 2.403E-16

689555
type: LocalParameter
units: 371397
value: 3.0024108E-17

375315
type: SpeciesReference
stoichiometry: 1.0
species: 738219

738219
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

375303
type: SpeciesReference
stoichiometry: 1.0
species: 738199

375291
type: SpeciesReference
stoichiometry: 1.0
species: 737819

737819
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

745558
type: Reaction
kinetic law: 376446
product: 376434
product: 376422
reactant: 376409
fast: false
reversible: false

376446
type: KineticLaw
local parameters: 689623
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx

689623
type: LocalParameter
units: 371312
value: 1.8E-16

376434
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376422
type: SpeciesReference
stoichiometry: 1.0
species: 741419

376409
type: SpeciesReference
stoichiometry: 1.0
species: 738439

738439
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

749018
type: Reaction
kinetic law: 384827
product: 384815
reactant: 384803
reactant: 384791
fast: false
reversible: true

384827
type: KineticLaw
local parameters: 690015
local parameters: 690013
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx

690015
type: LocalParameter
units: 371312
value: 6.8E-18

690013
type: LocalParameter
units: 371397
value: 8.7498E-18

384815
type: SpeciesReference
stoichiometry: 1.0
species: 740759

740759
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

384803
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384791
type: SpeciesReference
stoichiometry: 1.0
species: 741779

744418
type: Reaction
kinetic law: 373678
product: 373666
reactant: 373654
notes: This reaction comes into play when stochastic calculations are used. If we do not have a stochastic step here then the levels of basal_CaMKII_PSD are just a fixed number, which is probably not a good representation of stochasticity. Having a reaction for the basal activity ensures that the basal activity too exhibits some fluctuations.
fast: false
reversible: true

373678
type: KineticLaw
local parameters: 689474
local parameters: 689473
notes: kf*CaMKII_PSD_slash_basal_CaMKII_PSD_control-kb*CaMKII_PSD_slash_basal_CaMKII_PSD

689474
type: LocalParameter
units: 371312
value: 1.0E-17

689473
type: LocalParameter
units: 371312
value: 1.0E-17

373666
type: SpeciesReference
stoichiometry: 1.0
species: 742059

742059
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737359

373654
type: SpeciesReference
stoichiometry: 1.0
species: 742578

742578
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737359

739299
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

743578
type: Reaction
kinetic law: 371783
product: 371771
reactant: 371759
reactant: 371747
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true

371783
type: KineticLaw
local parameters: 689345
local parameters: 689344
notes: kf*CaM_slash_CaM_minus_PSD*Ca_minus_PSD^2-kb*CaM_minus_TR2_minus_Ca2_minus_PSD

689345
type: LocalParameter
units: 371312
value: 7.2E-16

689344
type: LocalParameter
units: 371349
value: 7.2E-16

371385
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

371373
type: SBMLUnit
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE

371361
type: SBMLUnit
exponent: 3.0
scale: 0
multipler: 1.0
kind: LITRE

371771
type: SpeciesReference
stoichiometry: 1.0
species: 740219

740219
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

371759
type: SpeciesReference
stoichiometry: 2.0
species: 740279

740279
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 737359

371747
type: SpeciesReference
stoichiometry: 1.0
species: 737859

738179
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

748178
type: Reaction
kinetic law: 382795
product: 382783
reactant: 382771
reactant: 382759
notes: This form has about twice the activity of the unphosphorylated form. See Sette et al JBC 269:28 18271-18274 1994. We\'ll ignore cGMP effects for now.
fast: false
reversible: true

382795
type: KineticLaw
local parameters: 689920
local parameters: 689919
notes: k1*cAMP*AC_slash_cAMP_minus_PDE_star_-k2*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx

689920
type: LocalParameter
units: 371312
value: 7.2E-15

689919
type: LocalParameter
units: 371397
value: 4.5359838E-16

382783
type: SpeciesReference
stoichiometry: 1.0
species: 740099

740099
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

382771
type: SpeciesReference
stoichiometry: 1.0
species: 740079

740079
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

382759
type: SpeciesReference
stoichiometry: 1.0
species: 737539

745278
type: Reaction
kinetic law: 375761
product: 375749
product: 375737
reactant: 375725
fast: false
reversible: false

375761
type: KineticLaw
local parameters: 689576
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx

689576
type: LocalParameter
units: 371312
value: 3.06E-17

375749
type: SpeciesReference
stoichiometry: 1.0
species: 738199

375737
type: SpeciesReference
stoichiometry: 1.0
species: 740359

740359
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

375725
type: SpeciesReference
stoichiometry: 1.0
species: 738299

738299
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

741659
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

737779
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 737339

740459
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

747438
type: Reaction
kinetic law: 380996
product: 380984
product: 380972
reactant: 380960
fast: false
reversible: false

380996
type: KineticLaw
local parameters: 689835
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx

689835
type: LocalParameter
units: 371312
value: 5.4E-16

380984
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380972
type: SpeciesReference
stoichiometry: 1.0
species: 741359

380960
type: SpeciesReference
stoichiometry: 1.0
species: 739619

739619
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

750658
type: Reaction
kinetic law: 388812
product: 388800
reactant: 388788
reactant: 388776
fast: false
reversible: true

388812
type: KineticLaw
local parameters: 690190
local parameters: 690188
notes: k1*AMPAR_memb_slash_A_B831_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx

690190
type: LocalParameter
units: 371312
value: 2.0E-17

690188
type: LocalParameter
units: 371397
value: 2.77776E-19

388800
type: SpeciesReference
stoichiometry: 1.0
species: 742298

742298
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 737359

388788
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388776
type: SpeciesReference
stoichiometry: 1.0
species: 741579

741579
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

737479
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

744438
type: Reaction
kinetic law: 373726
product: 373714
product: 373702
reactant: 373690
fast: false
reversible: true

373726
type: KineticLaw
local parameters: 689477
local parameters: 689476
notes: kf*CaMKII_PSD_slash_CaMKII_minus_CaM_minus_PSD-kb*CaM_minus_Ca4_minus_PSD*CaMKII_PSD_slash_CaMKII_minus_PSD

689477
type: LocalParameter
units: 371397
value: 0.0

689476
type: LocalParameter
units: 371312
value: 5.0E-17

373714
type: SpeciesReference
stoichiometry: 1.0
species: 741959

373702
type: SpeciesReference
stoichiometry: 1.0
species: 740259

373690
type: SpeciesReference
stoichiometry: 1.0
species: 741979

742858
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

737959
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

748118
type: Reaction
kinetic law: 382650
modifier: 382637
product: 382624
reactant: 382611
notes: Reduced Km to match expt data for basal activation of AC2 by PKC. Now k1 = 2.9e-6, k2 = 72, k3 = 18 18 Feb: Raised Km to 300 based on BRENDA data. Unlikely to make much difference, given the vast amount of ATP.
fast: false
reversible: false

382650
type: KineticLaw
local parameters: 689913
local parameters: 689911
notes: kcat*AC_slash_AC2_star_*AC_slash_ATP/(Km+AC_slash_ATP)

689913
type: LocalParameter
units: 371276
value: 300.001920012288

689911
type: LocalParameter
units: 371312
value: 1.8E-16

739979
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

382624
type: SpeciesReference
stoichiometry: 1.0
species: 737539

382611
type: SpeciesReference
stoichiometry: 1.0
species: 742438

742438
type: Species
notes: ATP is present in all cells between 2 and 10 mM. See Lehninger
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2000.0
initial amount: NaN
in compartment: 737339

746398
type: Reaction
kinetic law: 378478
product: 378466
product: 378454
reactant: 378441
fast: false
reversible: false

378478
type: KineticLaw
local parameters: 689718
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx

689718
type: LocalParameter
units: 371312
value: 1.8E-16

378466
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378454
type: SpeciesReference
stoichiometry: 1.0
species: 741579

378441
type: SpeciesReference
stoichiometry: 1.0
species: 738879

745218
type: Reaction
kinetic law: 375616
product: 375604
reactant: 375592
reactant: 375580
fast: false
reversible: true

375616
type: KineticLaw
local parameters: 689570
local parameters: 689569
notes: k1*PP1_PSD_slash_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx

689570
type: LocalParameter
units: 371312
value: 1.224E-16

689569
type: LocalParameter
units: 371397
value: 3.420036E-18

375604
type: SpeciesReference
stoichiometry: 1.0
species: 738279

375592
type: SpeciesReference
stoichiometry: 1.0
species: 738199

375580
type: SpeciesReference
stoichiometry: 1.0
species: 740319

740319
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

745918
type: Reaction
kinetic law: 377316
product: 377303
product: 377291
reactant: 377278
fast: false
reversible: false

377316
type: KineticLaw
local parameters: 689664
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx

689664
type: LocalParameter
units: 371312
value: 1.8E-16

377303
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377291
type: SpeciesReference
stoichiometry: 1.0
species: 741479

741479
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

377278
type: SpeciesReference
stoichiometry: 1.0
species: 738619

738619
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

750458
type: Reaction
kinetic law: 388328
product: 388316
reactant: 388304
reactant: 388292
fast: false
reversible: true

388328
type: KineticLaw
local parameters: 690170
local parameters: 690168
notes: k1*AMPAR_memb_slash_A845_star__B*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx

690170
type: LocalParameter
units: 371312
value: 2.0E-17

690168
type: LocalParameter
units: 371397
value: 2.77776E-19

388316
type: SpeciesReference
stoichiometry: 1.0
species: 742198

742198
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 737359

388304
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388292
type: SpeciesReference
stoichiometry: 1.0
species: 741619

738739
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

745998
type: Reaction
kinetic law: 377508
product: 377496
product: 377484
reactant: 377472
fast: false
reversible: false

377508
type: KineticLaw
local parameters: 689673
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx

689673
type: LocalParameter
units: 371312
value: 1.8E-16

377496
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377484
type: SpeciesReference
stoichiometry: 1.0
species: 741619

377472
type: SpeciesReference
stoichiometry: 1.0
species: 738659

738659
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

744778
type: Reaction
kinetic law: 374550
product: 374538
reactant: 374526
reactant: 374514
notes: Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
fast: false
reversible: true

374550
type: KineticLaw
local parameters: 689521
local parameters: 689519
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx

689521
type: LocalParameter
units: 371312
value: 2.16E-15

689519
type: LocalParameter
units: 371397
value: 1.1894364E-17

374538
type: SpeciesReference
stoichiometry: 1.0
species: 737679

374526
type: SpeciesReference
stoichiometry: 1.0
species: 742598

742598
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

374514
type: SpeciesReference
stoichiometry: 1.0
species: 737659

750798
type: Reaction
kinetic law: 389161
product: 389148
product: 389135
reactant: 389122
fast: false
reversible: false

389161
type: KineticLaw
local parameters: 690203
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx

690203
type: LocalParameter
units: 371312
value: 5.0E-18

389148
type: SpeciesReference
stoichiometry: 1.0
species: 742978

389135
type: SpeciesReference
stoichiometry: 1.0
species: 741659

389122
type: SpeciesReference
stoichiometry: 1.0
species: 742358

742358
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 737359

746578
type: Reaction
kinetic law: 378914
product: 378902
reactant: 378890
reactant: 378878
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true

378914
type: KineticLaw
local parameters: 689739
local parameters: 689737
notes: k1*CaM_slash_neurogranin_star__PSD*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx

689739
type: LocalParameter
units: 371312
value: 2.403E-16

689737
type: LocalParameter
units: 371397
value: 3.336012E-18

378902
type: SpeciesReference
stoichiometry: 1.0
species: 738979

378890
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378878
type: SpeciesReference
stoichiometry: 1.0
species: 737919

748938
type: Reaction
kinetic law: 384634
product: 384622
reactant: 384610
reactant: 384597
fast: false
reversible: true

384634
type: KineticLaw
local parameters: 690006
local parameters: 690004
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx

690006
type: LocalParameter
units: 371312
value: 6.8E-18

690004
type: LocalParameter
units: 371397
value: 8.7498E-18

384622
type: SpeciesReference
stoichiometry: 1.0
species: 740719

740719
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

384610
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384597
type: SpeciesReference
stoichiometry: 1.0
species: 741839

750018
type: Reaction
kinetic law: 387266
product: 387254
reactant: 387242
reactant: 387230
fast: false
reversible: true

387266
type: KineticLaw
local parameters: 690126
local parameters: 690124
notes: k1*CaMKII_PSD_slash_CaMKII_minus_CaM_minus_PSD*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD-k2*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx

690126
type: LocalParameter
units: 371312
value: 2.0E-17

690124
type: LocalParameter
units: 371397
value: 7.8126E-20

387254
type: SpeciesReference
stoichiometry: 1.0
species: 742018

742018
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

387242
type: SpeciesReference
stoichiometry: 1.0
species: 742918

387230
type: SpeciesReference
stoichiometry: 1.0
species: 741979

738259
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

750318
type: Reaction
kinetic law: 387990
product: 387978
product: 387966
reactant: 387953
fast: false
reversible: false

387990
type: KineticLaw
local parameters: 690155
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx

690155
type: LocalParameter
units: 371312
value: 5.0E-18

387978
type: SpeciesReference
stoichiometry: 1.0
species: 742978

387966
type: SpeciesReference
stoichiometry: 1.0
species: 741639

387953
type: SpeciesReference
stoichiometry: 1.0
species: 742118

740399
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

740799
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

746058
type: Reaction
kinetic law: 377654
product: 377642
reactant: 377630
reactant: 377618
fast: false
reversible: true

377654
type: KineticLaw
local parameters: 689680
local parameters: 689679
notes: k1*AMPAR_memb_slash_A845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx

689680
type: LocalParameter
units: 371312
value: 7.2E-16

689679
type: LocalParameter
units: 371397
value: 2.011824E-17

377642
type: SpeciesReference
stoichiometry: 1.0
species: 738719

377630
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377618
type: SpeciesReference
stoichiometry: 1.0
species: 741619

748418
type: Reaction
kinetic law: 383377
product: 383365
reactant: 383353
reactant: 383341
fast: false
reversible: true

383377
type: KineticLaw
local parameters: 689947
local parameters: 689946
notes: k1*AMPAR_memb_slash_A_B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx

689947
type: LocalParameter
units: 371312
value: 6.8E-18

689946
type: LocalParameter
units: 371397
value: 8.7498E-18

383365
type: SpeciesReference
stoichiometry: 1.0
species: 740459

383353
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383341
type: SpeciesReference
stoichiometry: 1.0
species: 741679

742238
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 737359

737799
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

740039
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.555555555555556
initial amount: NaN
in compartment: 737339

749178
type: Reaction
kinetic law: 385215
product: 385203
reactant: 385191
reactant: 385179
fast: false
reversible: true

385215
type: KineticLaw
local parameters: 690033
local parameters: 690031
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx

690033
type: LocalParameter
units: 371312
value: 1.4E-17

690031
type: LocalParameter
units: 371397
value: 8.7498E-18

385203
type: SpeciesReference
stoichiometry: 1.0
species: 740839

385191
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385179
type: SpeciesReference
stoichiometry: 1.0
species: 741699

746238
type: Reaction
kinetic law: 378091
product: 378079
product: 378067
reactant: 378055
fast: false
reversible: false

378091
type: KineticLaw
local parameters: 689700
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx

689700
type: LocalParameter
units: 371312
value: 1.8E-16

378079
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378067
type: SpeciesReference
stoichiometry: 1.0
species: 741559

378055
type: SpeciesReference
stoichiometry: 1.0
species: 738799

738799
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

749778
type: Reaction
kinetic law: 386687
product: 386675
reactant: 386662
reactant: 386650
fast: false
reversible: true

386687
type: KineticLaw
local parameters: 690100
local parameters: 690099
notes: k1*CaMKII_PSD_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD-k2*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

690100
type: LocalParameter
units: 371312
value: 8.0E-18

690099
type: LocalParameter
units: 371397
value: 4.99998E-18

386675
type: SpeciesReference
stoichiometry: 1.0
species: 741879

741879
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

386662
type: SpeciesReference
stoichiometry: 1.0
species: 741859

386650
type: SpeciesReference
stoichiometry: 1.0
species: 741998

741998
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

750378
type: Reaction
kinetic law: 388135
product: 388123
reactant: 388111
reactant: 388099
fast: false
reversible: true

388135
type: KineticLaw
local parameters: 690162
local parameters: 690160
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx

690162
type: LocalParameter
units: 371312
value: 2.0E-17

690160
type: LocalParameter
units: 371397
value: 2.77776E-19

388123
type: SpeciesReference
stoichiometry: 1.0
species: 742158

388111
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388099
type: SpeciesReference
stoichiometry: 1.0
species: 741719

741719
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

745438
type: Reaction
kinetic law: 376147
product: 376135
product: 376123
reactant: 376111
fast: false
reversible: false

376147
type: KineticLaw
local parameters: 689610
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx

689610
type: LocalParameter
units: 371312
value: 1.8E-16

376135
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376123
type: SpeciesReference
stoichiometry: 1.0
species: 741459

376111
type: SpeciesReference
stoichiometry: 1.0
species: 738379

738379
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

737499
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

742878
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

737979
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 737339

739899
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

750098
type: Reaction
kinetic law: 387460
product: 387447
reactant: 387435
reactant: 387423
fast: false
reversible: true

387460
type: KineticLaw
local parameters: 690134
local parameters: 690132
notes: k1*CaMKII_PSD_slash_CaMKII_minus_thr286_minus_PSD*CaMKII_PSD_slash_tot_minus_auto_minus_PSD-k2*CaMKII_PSD_slash_tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx

690134
type: LocalParameter
units: 371312
value: 2.4E-16

690132
type: LocalParameter
units: 371397
value: 6.0E-19

387447
type: SpeciesReference
stoichiometry: 1.0
species: 742038

387435
type: SpeciesReference
stoichiometry: 1.0
species: 742938

387423
type: SpeciesReference
stoichiometry: 1.0
species: 741978

743838
type: Reaction
kinetic law: 372397
product: 372385
reactant: 372373
reactant: 372361
fast: false
reversible: true

372397
type: KineticLaw
local parameters: 689384
local parameters: 689383
notes: kf*cAMP*PKA_slash_R2C2_minus_cAMP3-kb*PKA_slash_R2C2_minus_cAMP4

689384
type: LocalParameter
units: 371312
value: 2.925E-15

689383
type: LocalParameter
units: 371397
value: 6.750054E-15

372385
type: SpeciesReference
stoichiometry: 1.0
species: 739139

372373
type: SpeciesReference
stoichiometry: 1.0
species: 739119

739119
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

372361
type: SpeciesReference
stoichiometry: 1.0
species: 737539

749958
type: Reaction
kinetic law: 387122
product: 387110
product: 387098
reactant: 387086
fast: false
reversible: false

387122
type: KineticLaw
local parameters: 690119
notes: k3*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

690119
type: LocalParameter
units: 371312
value: 2.0E-18

387110
type: SpeciesReference
stoichiometry: 1.0
species: 741859

387098
type: SpeciesReference
stoichiometry: 1.0
species: 741959

387086
type: SpeciesReference
stoichiometry: 1.0
species: 741938

741938
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

749698
type: Reaction
kinetic law: 386481
product: 386469
reactant: 386457
reactant: 386445
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

386481
type: KineticLaw
local parameters: 690091
local parameters: 690090
notes: k1*CaM_slash_neurogranin_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx

690091
type: LocalParameter
units: 371312
value: 2.106E-16

690090
type: LocalParameter
units: 371397
value: 1.020006E-18

386469
type: SpeciesReference
stoichiometry: 1.0
species: 741119

386457
type: SpeciesReference
stoichiometry: 1.0
species: 741039

386445
type: SpeciesReference
stoichiometry: 1.0
species: 737899

748738
type: Reaction
kinetic law: 384152
product: 384140
reactant: 384128
reactant: 384116
fast: false
reversible: true

384152
type: KineticLaw
local parameters: 689983
local parameters: 689982
notes: k1*AMPAR_memb_slash_A831_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx

689983
type: LocalParameter
units: 371312
value: 1.4E-17

689982
type: LocalParameter
units: 371397
value: 8.7498E-18

384140
type: SpeciesReference
stoichiometry: 1.0
species: 740619

384128
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384116
type: SpeciesReference
stoichiometry: 1.0
species: 741559

746798
type: Reaction
kinetic law: 379445
product: 379433
product: 379421
reactant: 379409
fast: false
reversible: false

379445
type: KineticLaw
local parameters: 689763
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx

689763
type: LocalParameter
units: 371312
value: 8.1E-16

379433
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379421
type: SpeciesReference
stoichiometry: 1.0
species: 740319

379409
type: SpeciesReference
stoichiometry: 1.0
species: 739299

747278
type: Reaction
kinetic law: 380609
product: 380596
product: 380584
reactant: 380572
fast: false
reversible: false

380609
type: KineticLaw
local parameters: 689817
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx

689817
type: LocalParameter
units: 371312
value: 5.4E-16

380596
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380584
type: SpeciesReference
stoichiometry: 1.0
species: 741359

380572
type: SpeciesReference
stoichiometry: 1.0
species: 739539

739539
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

747078
type: Reaction
kinetic law: 380126
product: 380114
product: 380102
reactant: 380089
fast: false
reversible: false

380126
type: KineticLaw
local parameters: 689794
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx

689794
type: LocalParameter
units: 371312
value: 5.4E-16

380114
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380102
type: SpeciesReference
stoichiometry: 1.0
species: 741379

741379
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

380089
type: SpeciesReference
stoichiometry: 1.0
species: 739439

739439
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

746818
type: Reaction
kinetic law: 379494
product: 379481
reactant: 379469
reactant: 379457
fast: false
reversible: true

379494
type: KineticLaw
local parameters: 689766
local parameters: 689764
notes: k1*AMPAR_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx

689766
type: LocalParameter
units: 371312
value: 2.16E-15

689764
type: LocalParameter
units: 371397
value: 3.5998992E-16

379481
type: SpeciesReference
stoichiometry: 1.0
species: 739319

379469
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379457
type: SpeciesReference
stoichiometry: 1.0
species: 741199

741199
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

750038
type: Reaction
kinetic law: 387315
product: 387303
product: 387291
reactant: 387278
fast: false
reversible: false

387315
type: KineticLaw
local parameters: 690127
notes: k3*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx

690127
type: LocalParameter
units: 371312
value: 5.0E-18

387303
type: SpeciesReference
stoichiometry: 1.0
species: 742918

387291
type: SpeciesReference
stoichiometry: 1.0
species: 741998

387278
type: SpeciesReference
stoichiometry: 1.0
species: 742018

744298
type: Reaction
kinetic law: 373447
product: 373435
reactant: 373423
reactant: 373411
fast: false
reversible: true

373447
type: KineticLaw
local parameters: 689456
local parameters: 689455
notes: kf*AMPAR_slash_A831_star_845_star__B845_star_*Anchor-kb*AMPAR_memb_slash_A831_star_845_star__B845_star_

689456
type: LocalParameter
units: 371312
value: 8.0E-20

689455
type: LocalParameter
units: 371397
value: 1.08E-19

373435
type: SpeciesReference
stoichiometry: 1.0
species: 741799

373423
type: SpeciesReference
stoichiometry: 1.0
species: 741519

373411
type: SpeciesReference
stoichiometry: 1.0
species: 741319

737320
type: Compartment
constant: true
size: 1.0E-18
spatial dimensions: 3.0

747218
type: Reaction
kinetic law: 380463
product: 380451
reactant: 380439
reactant: 380427
fast: false
reversible: true

380463
type: KineticLaw
local parameters: 689811
local parameters: 689809
notes: k1*AMPAR_slash_A_B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx

689811
type: LocalParameter
units: 371312
value: 2.16E-15

689809
type: LocalParameter
units: 371397
value: 3.5998992E-16

380451
type: SpeciesReference
stoichiometry: 1.0
species: 739519

380439
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380427
type: SpeciesReference
stoichiometry: 1.0
species: 741379

742639
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737339

744098
type: Reaction
kinetic law: 373012
product: 373000
product: 372988
reactant: 372976
fast: false
reversible: true

373012
type: KineticLaw
local parameters: 689426
local parameters: 689425
notes: kf*AMPAR_memb_slash_A831_star__B831_star_-kb*AMPAR_slash_A831_star__B831_star_*Anchor

689426
type: LocalParameter
units: 371397
value: 0.0

689425
type: LocalParameter
units: 371312
value: 8.0E-21

373000
type: SpeciesReference
stoichiometry: 1.0
species: 741519

372988
type: SpeciesReference
stoichiometry: 1.0
species: 741459

372976
type: SpeciesReference
stoichiometry: 1.0
species: 741599

741599
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

749398
type: Reaction
kinetic law: 385744
product: 385732
product: 385720
reactant: 385708
fast: false
reversible: false

385744
type: KineticLaw
local parameters: 690057
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx

690057
type: LocalParameter
units: 371312
value: 3.5E-18

385732
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385720
type: SpeciesReference
stoichiometry: 1.0
species: 741579

385708
type: SpeciesReference
stoichiometry: 1.0
species: 740939

740939
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

749358
type: Reaction
kinetic law: 385648
product: 385636
product: 385623
reactant: 385611
fast: false
reversible: false

385648
type: KineticLaw
local parameters: 690052
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx

690052
type: LocalParameter
units: 371312
value: 3.5E-18

385636
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385623
type: SpeciesReference
stoichiometry: 1.0
species: 741699

385611
type: SpeciesReference
stoichiometry: 1.0
species: 740919

740919
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

746458
type: Reaction
kinetic law: 378624
product: 378612
reactant: 378600
reactant: 378587
fast: false
reversible: true

378624
type: KineticLaw
local parameters: 689725
local parameters: 689724
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx

689725
type: LocalParameter
units: 371312
value: 7.2E-16

689724
type: LocalParameter
units: 371397
value: 2.011824E-17

378612
type: SpeciesReference
stoichiometry: 1.0
species: 738919

738919
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

378600
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378587
type: SpeciesReference
stoichiometry: 1.0
species: 741839

738759
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

741059
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00538592592592593
initial amount: NaN
in compartment: 737339

748578
type: Reaction
kinetic law: 383765
product: 383753
reactant: 383741
reactant: 383729
fast: false
reversible: true

383765
type: KineticLaw
local parameters: 689965
local parameters: 689964
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx

689965
type: LocalParameter
units: 371312
value: 6.8E-18

689964
type: LocalParameter
units: 371397
value: 8.7498E-18

383753
type: SpeciesReference
stoichiometry: 1.0
species: 740539

383741
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383729
type: SpeciesReference
stoichiometry: 1.0
species: 741639

742958
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737359

744238
type: Reaction
kinetic law: 373302
product: 373290
reactant: 373278
fast: false
reversible: true

373302
type: KineticLaw
local parameters: 689447
local parameters: 689446
notes: kf*AMPAR_slash_A845_star__B845_star_-kb*AMPAR_slash_AMPAR_deg

689447
type: LocalParameter
units: 371312
value: 0.0

689446
type: LocalParameter
units: 371312
value: 3.24E-21

373290
type: SpeciesReference
stoichiometry: 1.0
species: 742478

373278
type: SpeciesReference
stoichiometry: 1.0
species: 741299

741299
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

749498
type: Reaction
kinetic law: 385987
product: 385975
reactant: 385963
reactant: 385951
fast: false
reversible: true

385987
type: KineticLaw
local parameters: 690069
local parameters: 690067
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx

690069
type: LocalParameter
units: 371312
value: 1.4E-17

690067
type: LocalParameter
units: 371397
value: 8.7498E-18

385975
type: SpeciesReference
stoichiometry: 1.0
species: 740999

740999
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

385963
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385951
type: SpeciesReference
stoichiometry: 1.0
species: 741659

738939
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

742258
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 737359

745598
type: Reaction
kinetic law: 376542
product: 376530
product: 376518
reactant: 376506
fast: false
reversible: false

376542
type: KineticLaw
local parameters: 689628
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx

689628
type: LocalParameter
units: 371312
value: 1.8E-16

376530
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376518
type: SpeciesReference
stoichiometry: 1.0
species: 741459

376506
type: SpeciesReference
stoichiometry: 1.0
species: 738459

738459
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

747958
type: Reaction
kinetic law: 382254
product: 382242
product: 382230
reactant: 382218
fast: false
reversible: false

382254
type: KineticLaw
local parameters: 689893
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx

689893
type: LocalParameter
units: 371312
value: 5.4E-16

382242
type: SpeciesReference
stoichiometry: 1.0
species: 739239

382230
type: SpeciesReference
stoichiometry: 1.0
species: 741839

382218
type: SpeciesReference
stoichiometry: 1.0
species: 739879

739879
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

749638
type: Reaction
kinetic law: 386337
product: 386325
product: 386312
product: 386300
reactant: 386288
fast: false
reversible: false

386337
type: KineticLaw
local parameters: 690084
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx

690084
type: LocalParameter
units: 371312
value: 3.15E-17

386325
type: SpeciesReference
stoichiometry: 1.0
species: 741039

386312
type: SpeciesReference
stoichiometry: 1.0
species: 737819

386300
type: SpeciesReference
stoichiometry: 1.0
species: 737779

386288
type: SpeciesReference
stoichiometry: 1.0
species: 741079

741079
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

749058
type: Reaction
kinetic law: 384924
product: 384912
reactant: 384899
reactant: 384887
fast: false
reversible: true

384924
type: KineticLaw
local parameters: 690019
local parameters: 690018
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx

690019
type: LocalParameter
units: 371312
value: 6.8E-18

690018
type: LocalParameter
units: 371397
value: 8.7498E-18

384912
type: SpeciesReference
stoichiometry: 1.0
species: 740779

384899
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384887
type: SpeciesReference
stoichiometry: 1.0
species: 741659

743538
type: Reaction
kinetic law: 371699
product: 371686
reactant: 371674
reactant: 371662
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true

371699
type: KineticLaw
local parameters: 689339
local parameters: 689338
notes: kf*CaM_slash_neurogranin*CaM_slash_CaM-kb*CaM_slash_neurogranin_minus_CaM

689339
type: LocalParameter
units: 371312
value: 9.0E-17

689338
type: LocalParameter
units: 371397
value: 2.7000216E-17

371686
type: SpeciesReference
stoichiometry: 1.0
species: 737799

371674
type: SpeciesReference
stoichiometry: 1.0
species: 737779

371662
type: SpeciesReference
stoichiometry: 1.0
species: 737839

737839
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 737339

739479
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

745118
type: Reaction
kinetic law: 375376
product: 375364
product: 375352
reactant: 375340
fast: false
reversible: false

375376
type: KineticLaw
local parameters: 689558
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx

689558
type: LocalParameter
units: 371312
value: 6.03E-17

375364
type: SpeciesReference
stoichiometry: 1.0
species: 738199

375352
type: SpeciesReference
stoichiometry: 1.0
species: 737839

375340
type: SpeciesReference
stoichiometry: 1.0
species: 738219

745078
type: Reaction
kinetic law: 375279
product: 375267
product: 375255
reactant: 375243
fast: false
reversible: false

375279
type: KineticLaw
local parameters: 689554
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx

689554
type: LocalParameter
units: 371312
value: 1.8E-16

375267
type: SpeciesReference
stoichiometry: 1.0
species: 738059

375255
type: SpeciesReference
stoichiometry: 1.0
species: 740359

375243
type: SpeciesReference
stoichiometry: 1.0
species: 738139

740059
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

744678
type: Reaction
kinetic law: 374307
product: 374295
product: 374283
reactant: 374271
fast: false
reversible: false

374307
type: KineticLaw
local parameters: 689509
notes: k3*PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

689509
type: LocalParameter
units: 371312
value: 2.25E-16

374295
type: SpeciesReference
stoichiometry: 1.0
species: 737419

374283
type: SpeciesReference
stoichiometry: 1.0
species: 737659

374271
type: SpeciesReference
stoichiometry: 1.0
species: 737479

743558
type: Reaction
kinetic law: 371735
product: 371723
reactant: 371711
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true

371735
type: KineticLaw
local parameters: 689342
local parameters: 689341
notes: kf*CaM_slash_neurogranin_star_-kb*CaM_slash_neurogranin

689342
type: LocalParameter
units: 371312
value: 0.0

689341
type: LocalParameter
units: 371312
value: 4.5E-19

371723
type: SpeciesReference
stoichiometry: 1.0
species: 737839

371711
type: SpeciesReference
stoichiometry: 1.0
species: 737819

748198
type: Reaction
kinetic law: 382843
product: 382831
product: 382819
reactant: 382807
fast: false
reversible: false

382843
type: KineticLaw
local parameters: 689922
notes: k3*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx

689922
type: LocalParameter
units: 371312
value: 1.8E-15

382831
type: SpeciesReference
stoichiometry: 1.0
species: 740079

382819
type: SpeciesReference
stoichiometry: 1.0
species: 740019

382807
type: SpeciesReference
stoichiometry: 1.0
species: 740099

748158
type: Reaction
kinetic law: 382747
product: 382735
product: 382723
reactant: 382711
fast: false
reversible: false

382747
type: KineticLaw
local parameters: 689917
notes: k3*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx

689917
type: LocalParameter
units: 371312
value: 9.0E-16

382735
type: SpeciesReference
stoichiometry: 1.0
species: 740039

382723
type: SpeciesReference
stoichiometry: 1.0
species: 740019

382711
type: SpeciesReference
stoichiometry: 1.0
species: 740059

745258
type: Reaction
kinetic law: 375713
product: 375700
reactant: 375688
reactant: 375676
fast: false
reversible: true

375713
type: KineticLaw
local parameters: 689575
local parameters: 689573
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx

689575
type: LocalParameter
units: 371312
value: 1.224E-16

689573
type: LocalParameter
units: 371397
value: 3.420036E-18

375700
type: SpeciesReference
stoichiometry: 1.0
species: 738299

375688
type: SpeciesReference
stoichiometry: 1.0
species: 738199

375676
type: SpeciesReference
stoichiometry: 1.0
species: 740339

740339
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

748798
type: Reaction
kinetic law: 384297
product: 384285
product: 384273
reactant: 384261
fast: false
reversible: false

384297
type: KineticLaw
local parameters: 689989
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx

689989
type: LocalParameter
units: 371312
value: 1.7E-18

384285
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384273
type: SpeciesReference
stoichiometry: 1.0
species: 741759

384261
type: SpeciesReference
stoichiometry: 1.0
species: 740639

740639
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

745958
type: Reaction
kinetic law: 377412
product: 377400
product: 377388
reactant: 377376
fast: false
reversible: false

377412
type: KineticLaw
local parameters: 689668
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx

689668
type: LocalParameter
units: 371312
value: 1.8E-16

377400
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377388
type: SpeciesReference
stoichiometry: 1.0
species: 741679

377376
type: SpeciesReference
stoichiometry: 1.0
species: 738639

738639
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

747618
type: Reaction
kinetic law: 381431
product: 381419
reactant: 381407
reactant: 381395
fast: false
reversible: true

381431
type: KineticLaw
local parameters: 689856
local parameters: 689854
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx

689856
type: LocalParameter
units: 371312
value: 2.16E-15

689854
type: LocalParameter
units: 371397
value: 3.999888E-17

381419
type: SpeciesReference
stoichiometry: 1.0
species: 739719

739719
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

381407
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381395
type: SpeciesReference
stoichiometry: 1.0
species: 741739

738779
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

744738
type: Reaction
kinetic law: 374454
product: 374442
reactant: 374429
reactant: 374416
fast: false
reversible: true

374454
type: KineticLaw
local parameters: 689516
local parameters: 689515
notes: k1*CaMKII_slash_CaMK_minus_thr305*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

689516
type: LocalParameter
units: 371312
value: 9.0E-16

689515
type: LocalParameter
units: 371397
value: 2.2062942E-16

374442
type: SpeciesReference
stoichiometry: 1.0
species: 737519

737519
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

374429
type: SpeciesReference
stoichiometry: 1.0
species: 737419

374416
type: SpeciesReference
stoichiometry: 1.0
species: 737759

748978
type: Reaction
kinetic law: 384731
product: 384719
reactant: 384707
reactant: 384695
fast: false
reversible: true

384731
type: KineticLaw
local parameters: 690010
local parameters: 690009
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx

690010
type: LocalParameter
units: 371312
value: 6.8E-18

690009
type: LocalParameter
units: 371397
value: 8.7498E-18

384719
type: SpeciesReference
stoichiometry: 1.0
species: 740739

740739
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

384707
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384695
type: SpeciesReference
stoichiometry: 1.0
species: 741839

744918
type: Reaction
kinetic law: 374890
product: 374878
product: 374866
reactant: 374854
fast: false
reversible: false

374890
type: KineticLaw
local parameters: 689536
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx

689536
type: LocalParameter
units: 371312
value: 4.5E-17

374878
type: SpeciesReference
stoichiometry: 1.0
species: 742618

374866
type: SpeciesReference
stoichiometry: 1.0
species: 737619

737619
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

374854
type: SpeciesReference
stoichiometry: 1.0
species: 737739

737739
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.89444444444444E-5
initial amount: NaN
in compartment: 737339

750638
type: Reaction
kinetic law: 388764
product: 388752
product: 388740
reactant: 388728
fast: false
reversible: false

388764
type: KineticLaw
local parameters: 690187
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx

690187
type: LocalParameter
units: 371312
value: 5.0E-18

388752
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388740
type: SpeciesReference
stoichiometry: 1.0
species: 741659

388728
type: SpeciesReference
stoichiometry: 1.0
species: 742278

747758
type: Reaction
kinetic law: 381769
product: 381757
product: 381745
reactant: 381733
fast: false
reversible: false

381769
type: KineticLaw
local parameters: 689871
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx

689871
type: LocalParameter
units: 371312
value: 5.4E-16

381757
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381745
type: SpeciesReference
stoichiometry: 1.0
species: 741639

381733
type: SpeciesReference
stoichiometry: 1.0
species: 739779

745778
type: Reaction
kinetic law: 376976
product: 376964
reactant: 376952
reactant: 376940
fast: false
reversible: true

376976
type: KineticLaw
local parameters: 689649
local parameters: 689647
notes: k1*AMPAR_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx

689649
type: LocalParameter
units: 371312
value: 7.2E-16

689647
type: LocalParameter
units: 371397
value: 1.8106416E-16

376964
type: SpeciesReference
stoichiometry: 1.0
species: 738559

376952
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376940
type: SpeciesReference
stoichiometry: 1.0
species: 741299

744378
type: Reaction
kinetic law: 373605
product: 373593
reactant: 373581
fast: false
reversible: true

373605
type: KineticLaw
local parameters: 689468
local parameters: 689467
notes: kf*Ca_control_PSD-kb*Ca_minus_PSD

689468
type: LocalParameter
units: 371312
value: 1.0E-15

689467
type: LocalParameter
units: 371312
value: 1.0E-15

373593
type: SpeciesReference
stoichiometry: 1.0
species: 740279

373581
type: SpeciesReference
stoichiometry: 1.0
species: 742538

742538
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 737359

746298
type: Reaction
kinetic law: 378236
product: 378224
reactant: 378212
reactant: 378200
fast: false
reversible: true

378236
type: KineticLaw
local parameters: 689707
local parameters: 689706
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx

689707
type: LocalParameter
units: 371312
value: 7.2E-16

689706
type: LocalParameter
units: 371397
value: 2.011824E-17

378224
type: SpeciesReference
stoichiometry: 1.0
species: 738839

738839
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

378212
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378200
type: SpeciesReference
stoichiometry: 1.0
species: 741819

750358
type: Reaction
kinetic law: 388087
product: 388075
product: 388063
reactant: 388051
fast: false
reversible: false

388087
type: KineticLaw
local parameters: 690159
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx

690159
type: LocalParameter
units: 371312
value: 5.0E-18

388075
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388063
type: SpeciesReference
stoichiometry: 1.0
species: 741559

388051
type: SpeciesReference
stoichiometry: 1.0
species: 742138

741159
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.5
initial amount: NaN
in compartment: 737359

746098
type: Reaction
kinetic law: 377752
product: 377740
reactant: 377728
reactant: 377715
fast: false
reversible: true

377752
type: KineticLaw
local parameters: 689685
local parameters: 689683
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx

689685
type: LocalParameter
units: 371312
value: 7.2E-16

689683
type: LocalParameter
units: 371397
value: 2.011824E-17

377740
type: SpeciesReference
stoichiometry: 1.0
species: 738739

377728
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377715
type: SpeciesReference
stoichiometry: 1.0
species: 741799

750278
type: Reaction
kinetic law: 387893
product: 387881
product: 387869
reactant: 387857
fast: false
reversible: false

387893
type: KineticLaw
local parameters: 690151
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx

690151
type: LocalParameter
units: 371312
value: 5.0E-18

387881
type: SpeciesReference
stoichiometry: 1.0
species: 742978

387869
type: SpeciesReference
stoichiometry: 1.0
species: 741739

387857
type: SpeciesReference
stoichiometry: 1.0
species: 742098

742098
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 737359

748458
type: Reaction
kinetic law: 383475
product: 383463
reactant: 383450
reactant: 383437
fast: false
reversible: true

383475
type: KineticLaw
local parameters: 689952
local parameters: 689950
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx

689952
type: LocalParameter
units: 371312
value: 6.8E-18

689950
type: LocalParameter
units: 371397
value: 8.7498E-18

383463
type: SpeciesReference
stoichiometry: 1.0
species: 740479

740479
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

383450
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383437
type: SpeciesReference
stoichiometry: 1.0
species: 741799

744478
type: Reaction
kinetic law: 373823
product: 373811
reactant: 373799
reactant: 373787
notes: Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
fast: false
reversible: true

373823
type: KineticLaw
local parameters: 689483
local parameters: 689482
notes: kf*CaMKII_PSD_slash_CaMKII_minus_thr286_minus_PSD*CaM_minus_Ca4_minus_PSD-kb*CaMKII_PSD_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD

689483
type: LocalParameter
units: 371312
value: 1.0E-18

689482
type: LocalParameter
units: 371397
value: 1.00002E-14

373811
type: SpeciesReference
stoichiometry: 1.0
species: 741998

373799
type: SpeciesReference
stoichiometry: 1.0
species: 740259

373787
type: SpeciesReference
stoichiometry: 1.0
species: 741978

743738
type: Reaction
kinetic law: 372156
product: 372144
reactant: 372132
reactant: 372120
notes: going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1
fast: false
reversible: true

372156
type: KineticLaw
local parameters: 689369
local parameters: 689368
notes: kf*PP2B_slash_CaNAB*Ca^2-kb*PP2B_slash_CaNAB_minus_Ca2

689369
type: LocalParameter
units: 371312
value: 9.0E-17

689368
type: LocalParameter
units: 371349
value: 9.00720324E-13

372144
type: SpeciesReference
stoichiometry: 1.0
species: 738179

372132
type: SpeciesReference
stoichiometry: 2.0
species: 737559

372120
type: SpeciesReference
stoichiometry: 1.0
species: 738159

739499
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

743778
type: Reaction
kinetic law: 372252
product: 372240
reactant: 372228
reactant: 372216
notes: Hasler et al FASEB J 6:2734-2741 1992 say Kd =1e-7M for type II, 5.6e-8 M for type I. Take mean which comes to 2e-13 #/cell Smith et al PNAS USA 78:3 1591-1595 1981 have better data. First kf/kb=2.1e7/M = 3.5e-5 (#/cell). Ogreid and Doskeland Febs Lett 129:2 287-292 1981 have figs suggesting time course of complete assoc is < 1 min.
fast: false
reversible: true

372252
type: KineticLaw
local parameters: 689375
local parameters: 689374
notes: kf*PKA_slash_R2C2*cAMP-kb*PKA_slash_R2C2_minus_cAMP

689375
type: LocalParameter
units: 371312
value: 2.97E-15

689374
type: LocalParameter
units: 371397
value: 4.86E-15

372240
type: SpeciesReference
stoichiometry: 1.0
species: 739079

372228
type: SpeciesReference
stoichiometry: 1.0
species: 737539

372216
type: SpeciesReference
stoichiometry: 1.0
species: 739059

739059
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: 737339

748638
type: Reaction
kinetic law: 383910
product: 383898
product: 383886
reactant: 383874
fast: false
reversible: false

383910
type: KineticLaw
local parameters: 689971
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx

689971
type: LocalParameter
units: 371312
value: 3.5E-18

383898
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383886
type: SpeciesReference
stoichiometry: 1.0
species: 741719

383874
type: SpeciesReference
stoichiometry: 1.0
species: 740559

740559
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

747418
type: Reaction
kinetic law: 380948
product: 380936
reactant: 380924
reactant: 380912
fast: false
reversible: true

380948
type: KineticLaw
local parameters: 689833
local parameters: 689832
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx

689833
type: LocalParameter
units: 371312
value: 2.16E-15

689832
type: LocalParameter
units: 371397
value: 3.5998992E-16

380936
type: SpeciesReference
stoichiometry: 1.0
species: 739619

380924
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380912
type: SpeciesReference
stoichiometry: 1.0
species: 741479

745478
type: Reaction
kinetic law: 376244
product: 376232
product: 376220
reactant: 376208
fast: false
reversible: false

376244
type: KineticLaw
local parameters: 689614
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx

689614
type: LocalParameter
units: 371312
value: 1.8E-16

376232
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376220
type: SpeciesReference
stoichiometry: 1.0
species: 741199

376208
type: SpeciesReference
stoichiometry: 1.0
species: 738399

738399
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

737599
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

738419
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

749918
type: Reaction
kinetic law: 387025
product: 387013
product: 387001
reactant: 386989
fast: false
reversible: false

387025
type: KineticLaw
local parameters: 690115
notes: k3*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

690115
type: LocalParameter
units: 371312
value: 2.0E-18

387013
type: SpeciesReference
stoichiometry: 1.0
species: 741859

387001
type: SpeciesReference
stoichiometry: 1.0
species: 741939

386989
type: SpeciesReference
stoichiometry: 1.0
species: 741919

741919
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

747598
type: Reaction
kinetic law: 381383
product: 381371
product: 381358
reactant: 381346
fast: false
reversible: false

381383
type: KineticLaw
local parameters: 689853
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx

689853
type: LocalParameter
units: 371312
value: 5.4E-16

381371
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381358
type: SpeciesReference
stoichiometry: 1.0
species: 741679

381346
type: SpeciesReference
stoichiometry: 1.0
species: 739699

739699
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

746718
type: Reaction
kinetic law: 379253
product: 379240
product: 379228
reactant: 379216
fast: false
reversible: false

379253
type: KineticLaw
local parameters: 689754
notes: k3*PKA_slash_PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx

689754
type: LocalParameter
units: 371312
value: 8.1E-16

379240
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379228
type: SpeciesReference
stoichiometry: 1.0
species: 740079

379216
type: SpeciesReference
stoichiometry: 1.0
species: 739259

748778
type: Reaction
kinetic law: 384249
product: 384236
reactant: 384224
reactant: 384212
fast: false
reversible: true

384249
type: KineticLaw
local parameters: 689988
local parameters: 689986
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx

689988
type: LocalParameter
units: 371312
value: 6.8E-18

689986
type: LocalParameter
units: 371397
value: 8.7498E-18

384236
type: SpeciesReference
stoichiometry: 1.0
species: 740639

384224
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384212
type: SpeciesReference
stoichiometry: 1.0
species: 741819

742039
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

745978
type: Reaction
kinetic law: 377460
product: 377448
reactant: 377436
reactant: 377424
fast: false
reversible: true

377460
type: KineticLaw
local parameters: 689671
local parameters: 689670
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx

689671
type: LocalParameter
units: 371312
value: 7.2E-16

689670
type: LocalParameter
units: 371397
value: 2.011824E-17

377448
type: SpeciesReference
stoichiometry: 1.0
species: 738659

377436
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377424
type: SpeciesReference
stoichiometry: 1.0
species: 741719

745418
type: Reaction
kinetic law: 376099
product: 376087
reactant: 376075
reactant: 376063
fast: false
reversible: true

376099
type: KineticLaw
local parameters: 689608
local parameters: 689607
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx

689608
type: LocalParameter
units: 371312
value: 7.2E-16

689607
type: LocalParameter
units: 371397
value: 1.8106416E-16

376087
type: SpeciesReference
stoichiometry: 1.0
species: 738379

376075
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376063
type: SpeciesReference
stoichiometry: 1.0
species: 741479

747118
type: Reaction
kinetic law: 380222
product: 380210
product: 380198
reactant: 380186
fast: false
reversible: false

380222
type: KineticLaw
local parameters: 689799
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx

689799
type: LocalParameter
units: 371312
value: 5.4E-16

380210
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380198
type: SpeciesReference
stoichiometry: 1.0
species: 741399

741399
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

380186
type: SpeciesReference
stoichiometry: 1.0
species: 739459

748078
type: Reaction
kinetic law: 382545
product: 382533
product: 382520
reactant: 382508
fast: false
reversible: false

382545
type: KineticLaw
local parameters: 689907
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx

689907
type: LocalParameter
units: 371312
value: 5.4E-16

382533
type: SpeciesReference
stoichiometry: 1.0
species: 739239

382520
type: SpeciesReference
stoichiometry: 1.0
species: 741659

382508
type: SpeciesReference
stoichiometry: 1.0
species: 739939

739939
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

750078
type: Reaction
kinetic law: 387411
product: 387399
product: 387387
reactant: 387375
fast: false
reversible: false

387411
type: KineticLaw
local parameters: 690131
notes: k3*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_act_autoph_slash_CaM_act_autoph_cplx

690131
type: LocalParameter
units: 371312
value: 2.0E-17

387399
type: SpeciesReference
stoichiometry: 1.0
species: 742918

387387
type: SpeciesReference
stoichiometry: 1.0
species: 741978

387375
type: SpeciesReference
stoichiometry: 1.0
species: 742019

748038
type: Reaction
kinetic law: 382447
product: 382435
product: 382423
reactant: 382411
fast: false
reversible: false

382447
type: KineticLaw
local parameters: 689902
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx

689902
type: LocalParameter
units: 371312
value: 5.4E-16

382435
type: SpeciesReference
stoichiometry: 1.0
species: 739239

382423
type: SpeciesReference
stoichiometry: 1.0
species: 741779

382411
type: SpeciesReference
stoichiometry: 1.0
species: 739919

747258
type: Reaction
kinetic law: 380560
product: 380548
reactant: 380536
reactant: 380524
fast: false
reversible: true

380560
type: KineticLaw
local parameters: 689815
local parameters: 689814
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx

689815
type: LocalParameter
units: 371312
value: 2.16E-15

689814
type: LocalParameter
units: 371397
value: 3.5998992E-16

380548
type: SpeciesReference
stoichiometry: 1.0
species: 739539

380536
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380524
type: SpeciesReference
stoichiometry: 1.0
species: 741399

744138
type: Reaction
kinetic law: 373109
product: 373097
product: 373085
reactant: 373073
fast: false
reversible: true

373109
type: KineticLaw
local parameters: 689432
local parameters: 689431
notes: kf*AMPAR_memb_slash_A831_star__B-kb*AMPAR_slash_A831_star__B*Anchor

689432
type: LocalParameter
units: 371397
value: 0.0

689431
type: LocalParameter
units: 371312
value: 8.0E-21

373097
type: SpeciesReference
stoichiometry: 1.0
species: 741519

373085
type: SpeciesReference
stoichiometry: 1.0
species: 741219

373073
type: SpeciesReference
stoichiometry: 1.0
species: 741559

746498
type: Reaction
kinetic law: 378720
product: 378708
reactant: 378696
reactant: 378684
fast: false
reversible: true

378720
type: KineticLaw
local parameters: 689730
local parameters: 689728
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx

689730
type: LocalParameter
units: 371312
value: 7.2E-16

689728
type: LocalParameter
units: 371397
value: 2.011824E-17

378708
type: SpeciesReference
stoichiometry: 1.0
species: 738939

378696
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378684
type: SpeciesReference
stoichiometry: 1.0
species: 741659

750518
type: Reaction
kinetic law: 388473
product: 388461
product: 388449
reactant: 388437
fast: false
reversible: false

388473
type: KineticLaw
local parameters: 690175
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx

690175
type: LocalParameter
units: 371312
value: 5.0E-18

388461
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388449
type: SpeciesReference
stoichiometry: 1.0
species: 741579

388437
type: SpeciesReference
stoichiometry: 1.0
species: 742218

742218
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 737359

750598
type: Reaction
kinetic law: 388667
product: 388655
product: 388643
reactant: 388631
fast: false
reversible: false

388667
type: KineticLaw
local parameters: 690183
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx

690183
type: LocalParameter
units: 371312
value: 5.0E-18

388655
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388643
type: SpeciesReference
stoichiometry: 1.0
species: 741779

388631
type: SpeciesReference
stoichiometry: 1.0
species: 742258

745858
type: Reaction
kinetic law: 377170
product: 377158
reactant: 377146
reactant: 377134
fast: false
reversible: true

377170
type: KineticLaw
local parameters: 689658
local parameters: 689656
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx

689658
type: LocalParameter
units: 371312
value: 7.2E-16

689656
type: LocalParameter
units: 371397
value: 1.8106416E-16

377158
type: SpeciesReference
stoichiometry: 1.0
species: 738599

738599
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

377146
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377134
type: SpeciesReference
stoichiometry: 1.0
species: 741339

744278
type: Reaction
kinetic law: 373398
product: 373386
reactant: 373374
reactant: 373362
fast: false
reversible: true

373398
type: KineticLaw
local parameters: 689453
local parameters: 689452
notes: kf*AMPAR_slash_A845_star__B831_star_845_star_*Anchor-kb*AMPAR_memb_slash_A845_star__B831_star_845_star_

689453
type: LocalParameter
units: 371312
value: 8.0E-20

689452
type: LocalParameter
units: 371397
value: 1.08E-19

373386
type: SpeciesReference
stoichiometry: 1.0
species: 741819

373374
type: SpeciesReference
stoichiometry: 1.0
species: 741519

373362
type: SpeciesReference
stoichiometry: 1.0
species: 741339

749758
type: Reaction
kinetic law: 386638
product: 386626
product: 386614
product: 386602
reactant: 386590
fast: false
reversible: false

386638
type: KineticLaw
local parameters: 690097
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx

690097
type: LocalParameter
units: 371312
value: 3.15E-17

386626
type: SpeciesReference
stoichiometry: 1.0
species: 741039

386614
type: SpeciesReference
stoichiometry: 1.0
species: 737919

386602
type: SpeciesReference
stoichiometry: 1.0
species: 737859

386590
type: SpeciesReference
stoichiometry: 1.0
species: 741139

746638
type: Reaction
kinetic law: 379059
product: 379047
product: 379035
reactant: 379023
fast: false
reversible: false

379059
type: KineticLaw
local parameters: 689745
notes: k3*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx

689745
type: LocalParameter
units: 371312
value: 3.06E-18

379047
type: SpeciesReference
stoichiometry: 1.0
species: 738999

738999
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

379035
type: SpeciesReference
stoichiometry: 1.0
species: 737979

379023
type: SpeciesReference
stoichiometry: 1.0
species: 739019

739019
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

749538
type: Reaction
kinetic law: 386084
product: 386072
reactant: 386060
reactant: 386048
fast: false
reversible: true

386084
type: KineticLaw
local parameters: 690073
local parameters: 690072
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx

690073
type: LocalParameter
units: 371312
value: 1.4E-17

690072
type: LocalParameter
units: 371397
value: 8.7498E-18

386072
type: SpeciesReference
stoichiometry: 1.0
species: 741019

741019
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

386060
type: SpeciesReference
stoichiometry: 1.0
species: 740379

386048
type: SpeciesReference
stoichiometry: 1.0
species: 741599

371457
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

749378
type: Reaction
kinetic law: 385696
product: 385684
reactant: 385672
reactant: 385660
fast: false
reversible: true

385696
type: KineticLaw
local parameters: 690055
local parameters: 690054
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx

690055
type: LocalParameter
units: 371312
value: 1.4E-17

690054
type: LocalParameter
units: 371397
value: 8.7498E-18

385684
type: SpeciesReference
stoichiometry: 1.0
species: 740939

385672
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385660
type: SpeciesReference
stoichiometry: 1.0
species: 741599

749338
type: Reaction
kinetic law: 385599
product: 385587
reactant: 385575
reactant: 385563
fast: false
reversible: true

385599
type: KineticLaw
local parameters: 690051
local parameters: 690049
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx

690051
type: LocalParameter
units: 371312
value: 1.4E-17

690049
type: LocalParameter
units: 371397
value: 8.7498E-18

385587
type: SpeciesReference
stoichiometry: 1.0
species: 740919

385575
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385563
type: SpeciesReference
stoichiometry: 1.0
species: 741659

745518
type: Reaction
kinetic law: 376344
product: 376331
product: 376318
reactant: 376305
fast: false
reversible: false

376344
type: KineticLaw
local parameters: 689619
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx

689619
type: LocalParameter
units: 371312
value: 1.8E-16

376331
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376318
type: SpeciesReference
stoichiometry: 1.0
species: 741219

376305
type: SpeciesReference
stoichiometry: 1.0
species: 738419

749938
type: Reaction
kinetic law: 387074
product: 387062
reactant: 387050
reactant: 387037
fast: false
reversible: true

387074
type: KineticLaw
local parameters: 690118
local parameters: 690116
notes: k1*CaMKII_PSD_slash_CaMKII_minus_thr305_minus_PSD*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD-k2*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

690118
type: LocalParameter
units: 371312
value: 8.0E-18

690116
type: LocalParameter
units: 371397
value: 4.99998E-18

387062
type: SpeciesReference
stoichiometry: 1.0
species: 741938

387050
type: SpeciesReference
stoichiometry: 1.0
species: 741859

387037
type: SpeciesReference
stoichiometry: 1.0
species: 741939

739639
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

747998
type: Reaction
kinetic law: 382351
product: 382339
product: 382327
reactant: 382315
fast: false
reversible: false

382351
type: KineticLaw
local parameters: 689898
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx

689898
type: LocalParameter
units: 371312
value: 5.4E-16

382339
type: SpeciesReference
stoichiometry: 1.0
species: 739239

382327
type: SpeciesReference
stoichiometry: 1.0
species: 741839

382315
type: SpeciesReference
stoichiometry: 1.0
species: 739899

749678
type: Reaction
kinetic law: 386433
product: 386421
product: 386409
reactant: 386397
fast: false
reversible: false

386433
type: KineticLaw
local parameters: 690088
notes: k3*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx

690088
type: LocalParameter
units: 371312
value: 3.6E-16

386421
type: SpeciesReference
stoichiometry: 1.0
species: 741039

386409
type: SpeciesReference
stoichiometry: 1.0
species: 739979

386397
type: SpeciesReference
stoichiometry: 1.0
species: 741099

746778
type: Reaction
kinetic law: 379397
product: 379385
reactant: 379373
reactant: 379361
fast: false
reversible: true

379397
type: KineticLaw
local parameters: 689761
local parameters: 689760
notes: k1*PP1_PSD_slash_I1*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx

689761
type: LocalParameter
units: 371312
value: 3.24E-15

689760
type: LocalParameter
units: 371397
value: 5.99994E-17

379385
type: SpeciesReference
stoichiometry: 1.0
species: 739299

379373
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379361
type: SpeciesReference
stoichiometry: 1.0
species: 740299

746738
type: Reaction
kinetic law: 379301
product: 379289
reactant: 379277
reactant: 379265
notes: #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
fast: false
reversible: true

379301
type: KineticLaw
local parameters: 689757
local parameters: 689755
notes: k1*PP1_slash_I1*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx

689757
type: LocalParameter
units: 371312
value: 3.24E-15

689755
type: LocalParameter
units: 371397
value: 5.399946E-16

379289
type: SpeciesReference
stoichiometry: 1.0
species: 739279

379277
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379265
type: SpeciesReference
stoichiometry: 1.0
species: 737979

750838
type: Reaction
kinetic law: 389257
product: 389245
product: 389233
reactant: 389221
fast: false
reversible: false

389257
type: KineticLaw
local parameters: 690208
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx

690208
type: LocalParameter
units: 371312
value: 5.0E-18

389245
type: SpeciesReference
stoichiometry: 1.0
species: 742978

389233
type: SpeciesReference
stoichiometry: 1.0
species: 741599

389221
type: SpeciesReference
stoichiometry: 1.0
species: 742378

741179
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0925925925925926
initial amount: NaN
in compartment: 737339

745158
type: Reaction
kinetic law: 375472
product: 375460
product: 375448
reactant: 375436
fast: false
reversible: false

375472
type: KineticLaw
local parameters: 689563
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx

689563
type: LocalParameter
units: 371312
value: 3.06E-17

375460
type: SpeciesReference
stoichiometry: 1.0
species: 738199

375448
type: SpeciesReference
stoichiometry: 1.0
species: 737979

375436
type: SpeciesReference
stoichiometry: 1.0
species: 738239

738239
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

744638
type: Reaction
kinetic law: 374210
product: 374198
product: 374186
reactant: 374173
fast: false
reversible: false

374210
type: KineticLaw
local parameters: 689504
notes: k3*PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

689504
type: LocalParameter
units: 371312
value: 2.25E-16

374198
type: SpeciesReference
stoichiometry: 1.0
species: 737419

374186
type: SpeciesReference
stoichiometry: 1.0
species: 737579

737579
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 20.0
initial amount: NaN
in compartment: 737339

374173
type: SpeciesReference
stoichiometry: 1.0
species: 737459

737459
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

747478
type: Reaction
kinetic law: 381093
product: 381080
product: 381068
reactant: 381056
fast: false
reversible: false

381093
type: KineticLaw
local parameters: 689839
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_slash_PKA_cplx

689839
type: LocalParameter
units: 371312
value: 5.4E-16

381080
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381068
type: SpeciesReference
stoichiometry: 1.0
species: 741719

381056
type: SpeciesReference
stoichiometry: 1.0
species: 739639

749038
type: Reaction
kinetic law: 384875
product: 384863
product: 384851
reactant: 384839
fast: false
reversible: false

384875
type: KineticLaw
local parameters: 690016
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx

690016
type: LocalParameter
units: 371312
value: 1.7E-18

384863
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384851
type: SpeciesReference
stoichiometry: 1.0
species: 741599

384839
type: SpeciesReference
stoichiometry: 1.0
species: 740759

743518
type: Reaction
kinetic law: 371650
product: 371638
reactant: 371626
reactant: 371614
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true

371650
type: KineticLaw
local parameters: 689336
local parameters: 689335
notes: kf*CaM_minus_TR2_minus_Ca2*Ca-kb*CaM_minus_Ca3

689336
type: LocalParameter
units: 371312
value: 9.0E-16

689335
type: LocalParameter
units: 371397
value: 3.2400162E-16

371638
type: SpeciesReference
stoichiometry: 1.0
species: 737939

371626
type: SpeciesReference
stoichiometry: 1.0
species: 737559

371614
type: SpeciesReference
stoichiometry: 1.0
species: 737959

743598
type: Reaction
kinetic law: 371831
product: 371819
reactant: 371807
reactant: 371795
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true

371831
type: KineticLaw
local parameters: 689348
local parameters: 689347
notes: kf*CaM_minus_TR2_minus_Ca2_minus_PSD*Ca_minus_PSD-kb*CaM_minus_Ca3_minus_PSD

689348
type: LocalParameter
units: 371312
value: 1.0E-16

689347
type: LocalParameter
units: 371397
value: 3.6E-17

371819
type: SpeciesReference
stoichiometry: 1.0
species: 740239

740239
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

371807
type: SpeciesReference
stoichiometry: 1.0
species: 740279

371795
type: SpeciesReference
stoichiometry: 1.0
species: 740219

745298
type: Reaction
kinetic law: 375809
product: 375797
reactant: 375785
reactant: 375773
fast: false
reversible: true

375809
type: KineticLaw
local parameters: 689579
local parameters: 689578
notes: k1*AMPAR_slash_A845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx

689579
type: LocalParameter
units: 371312
value: 7.2E-16

689578
type: LocalParameter
units: 371397
value: 1.8106416E-16

375797
type: SpeciesReference
stoichiometry: 1.0
species: 738319

738319
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

375785
type: SpeciesReference
stoichiometry: 1.0
species: 738199

375773
type: SpeciesReference
stoichiometry: 1.0
species: 741239

740679
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

747658
type: Reaction
kinetic law: 381527
product: 381515
reactant: 381503
reactant: 381491
fast: false
reversible: true

381527
type: KineticLaw
local parameters: 689860
local parameters: 689859
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx

689860
type: LocalParameter
units: 371312
value: 2.16E-15

689859
type: LocalParameter
units: 371397
value: 3.999888E-17

381515
type: SpeciesReference
stoichiometry: 1.0
species: 739739

739739
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

381503
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381491
type: SpeciesReference
stoichiometry: 1.0
species: 741639

746438
type: Reaction
kinetic law: 378575
product: 378562
product: 378550
reactant: 378538
fast: false
reversible: false

378575
type: KineticLaw
local parameters: 689722
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx

689722
type: LocalParameter
units: 371312
value: 1.8E-16

378562
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378550
type: SpeciesReference
stoichiometry: 1.0
species: 741779

378538
type: SpeciesReference
stoichiometry: 1.0
species: 738899

742558
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00925933333333333
initial amount: NaN
in compartment: 737379

737699
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.44537037037037E-8
initial amount: NaN
in compartment: 737339

744658
type: Reaction
kinetic law: 374259
product: 374247
reactant: 374235
reactant: 374223
fast: false
reversible: true

374259
type: KineticLaw
local parameters: 689507
local parameters: 689506
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

689507
type: LocalParameter
units: 371312
value: 9.0E-16

689506
type: LocalParameter
units: 371397
value: 2.2062942E-16

374247
type: SpeciesReference
stoichiometry: 1.0
species: 737479

374235
type: SpeciesReference
stoichiometry: 1.0
species: 737419

374223
type: SpeciesReference
stoichiometry: 1.0
species: 737639

737639
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

738579
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

750678
type: Reaction
kinetic law: 388862
product: 388850
product: 388837
reactant: 388825
fast: false
reversible: false

388862
type: KineticLaw
local parameters: 690191
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx

690191
type: LocalParameter
units: 371312
value: 5.0E-18

388850
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388837
type: SpeciesReference
stoichiometry: 1.0
species: 741599

388825
type: SpeciesReference
stoichiometry: 1.0
species: 742298

747718
type: Reaction
kinetic law: 381672
product: 381660
product: 381648
reactant: 381636
fast: false
reversible: false

381672
type: KineticLaw
local parameters: 689866
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx

689866
type: LocalParameter
units: 371312
value: 5.4E-16

381660
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381648
type: SpeciesReference
stoichiometry: 1.0
species: 741739

381636
type: SpeciesReference
stoichiometry: 1.0
species: 739759

739759
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

745738
type: Reaction
kinetic law: 376880
product: 376868
reactant: 376856
reactant: 376844
fast: false
reversible: true

376880
type: KineticLaw
local parameters: 689644
local parameters: 689643
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx

689644
type: LocalParameter
units: 371312
value: 7.2E-16

689643
type: LocalParameter
units: 371397
value: 1.8106416E-16

376868
type: SpeciesReference
stoichiometry: 1.0
species: 738539

738539
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

376856
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376844
type: SpeciesReference
stoichiometry: 1.0
species: 741359

744958
type: Reaction
kinetic law: 374987
product: 374974
product: 374962
reactant: 374950
fast: false
reversible: false

374987
type: KineticLaw
local parameters: 689540
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx

689540
type: LocalParameter
units: 371312
value: 1.8E-16

374974
type: SpeciesReference
stoichiometry: 1.0
species: 738059

374962
type: SpeciesReference
stoichiometry: 1.0
species: 737979

374950
type: SpeciesReference
stoichiometry: 1.0
species: 738079

747798
type: Reaction
kinetic law: 381866
product: 381854
product: 381842
reactant: 381829
fast: false
reversible: false

381866
type: KineticLaw
local parameters: 689875
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx

689875
type: LocalParameter
units: 371312
value: 5.4E-16

381854
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381842
type: SpeciesReference
stoichiometry: 1.0
species: 741819

381829
type: SpeciesReference
stoichiometry: 1.0
species: 739799

744998
type: Reaction
kinetic law: 375084
product: 375072
product: 375060
reactant: 375048
fast: false
reversible: false

375084
type: KineticLaw
local parameters: 689545
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx

689545
type: LocalParameter
units: 371312
value: 1.8E-16

375072
type: SpeciesReference
stoichiometry: 1.0
species: 738059

375060
type: SpeciesReference
stoichiometry: 1.0
species: 738039

738039
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

375048
type: SpeciesReference
stoichiometry: 1.0
species: 738099

741259
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

746138
type: Reaction
kinetic law: 377848
product: 377836
reactant: 377824
reactant: 377812
fast: false
reversible: true

377848
type: KineticLaw
local parameters: 689689
local parameters: 689688
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx

689689
type: LocalParameter
units: 371312
value: 7.2E-16

689688
type: LocalParameter
units: 371397
value: 2.011824E-17

377836
type: SpeciesReference
stoichiometry: 1.0
species: 738759

377824
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377812
type: SpeciesReference
stoichiometry: 1.0
species: 741799

750238
type: Reaction
kinetic law: 387796
product: 387784
product: 387772
reactant: 387760
fast: false
reversible: false

387796
type: KineticLaw
local parameters: 690147
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx

690147
type: LocalParameter
units: 371312
value: 5.0E-18

387784
type: SpeciesReference
stoichiometry: 1.0
species: 742978

387772
type: SpeciesReference
stoichiometry: 1.0
species: 741799

387760
type: SpeciesReference
stoichiometry: 1.0
species: 742078

748498
type: Reaction
kinetic law: 383572
product: 383560
reactant: 383548
reactant: 383536
fast: false
reversible: true

383572
type: KineticLaw
local parameters: 689956
local parameters: 689955
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx

689956
type: LocalParameter
units: 371312
value: 6.8E-18

689955
type: LocalParameter
units: 371397
value: 8.7498E-18

383560
type: SpeciesReference
stoichiometry: 1.0
species: 740499

740499
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

383548
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383536
type: SpeciesReference
stoichiometry: 1.0
species: 741799

747318
type: Reaction
kinetic law: 380706
product: 380694
product: 380682
reactant: 380670
fast: false
reversible: false

380706
type: KineticLaw
local parameters: 689821
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx

689821
type: LocalParameter
units: 371312
value: 5.4E-16

380694
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380682
type: SpeciesReference
stoichiometry: 1.0
species: 741299

380670
type: SpeciesReference
stoichiometry: 1.0
species: 739559

739559
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

738479
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

744358
type: Reaction
kinetic law: 373569
product: 373556
reactant: 373544
fast: false
reversible: true

373569
type: KineticLaw
local parameters: 689465
local parameters: 689464
notes: kf*Ca_control_cyt-kb*Ca

689465
type: LocalParameter
units: 371312
value: 9.0E-15

689464
type: LocalParameter
units: 371312
value: 9.0E-15

373556
type: SpeciesReference
stoichiometry: 1.0
species: 737559

373544
type: SpeciesReference
stoichiometry: 1.0
species: 742518

742518
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 737339

746278
type: Reaction
kinetic law: 378188
product: 378176
product: 378164
reactant: 378152
fast: false
reversible: false

378188
type: KineticLaw
local parameters: 689704
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx

689704
type: LocalParameter
units: 371312
value: 1.8E-16

378176
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378164
type: SpeciesReference
stoichiometry: 1.0
species: 741759

378152
type: SpeciesReference
stoichiometry: 1.0
species: 738819

750338
type: Reaction
kinetic law: 388038
product: 388026
reactant: 388014
reactant: 388002
fast: false
reversible: true

388038
type: KineticLaw
local parameters: 690158
local parameters: 690156
notes: k1*AMPAR_memb_slash_A_B*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx

690158
type: LocalParameter
units: 371312
value: 2.0E-17

690156
type: LocalParameter
units: 371397
value: 2.77776E-19

388026
type: SpeciesReference
stoichiometry: 1.0
species: 742138

388014
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388002
type: SpeciesReference
stoichiometry: 1.0
species: 741539

747458
type: Reaction
kinetic law: 381044
product: 381032
reactant: 381020
reactant: 381008
fast: false
reversible: true

381044
type: KineticLaw
local parameters: 689838
local parameters: 689836
notes: k1*AMPAR_memb_slash_A_B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_slash_PKA_cplx

689838
type: LocalParameter
units: 371312
value: 2.16E-15

689836
type: LocalParameter
units: 371397
value: 3.999888E-17

381032
type: SpeciesReference
stoichiometry: 1.0
species: 739639

381020
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381008
type: SpeciesReference
stoichiometry: 1.0
species: 741679

749818
type: Reaction
kinetic law: 386783
product: 386771
reactant: 386759
reactant: 386747
fast: false
reversible: true

386783
type: KineticLaw
local parameters: 690105
local parameters: 690103
notes: k1*CaMKII_PSD_slash_CaMKII_minus_thr286_minus_PSD*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD-k2*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

690105
type: LocalParameter
units: 371312
value: 8.0E-18

690103
type: LocalParameter
units: 371397
value: 4.99998E-18

386771
type: SpeciesReference
stoichiometry: 1.0
species: 741899

741899
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

386759
type: SpeciesReference
stoichiometry: 1.0
species: 741859

386747
type: SpeciesReference
stoichiometry: 1.0
species: 741978

742458
type: Species
notes: This isn\'t explicitly present in the M&L model, but is obviously needed. I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim 7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs, which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984 Lets use a lower level of 30 nM, same ref....
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.5
initial amount: NaN
in compartment: 737339

743918
type: Reaction
kinetic law: 372590
product: 372578
reactant: 372566
reactant: 372554
notes: Half-max at 20 nM CaM (Tang et al JBC 266:13 8595-8603 1991 kb/kf = 20 nM = 12000 #/cell so kf = kb/12000 = kb * 8.333e-5
fast: false
reversible: true

372590
type: KineticLaw
local parameters: 689396
local parameters: 689395
notes: kf*CaM_minus_Ca4*AC_slash_AC1-kb*AC_slash_AC1_minus_CaM

689396
type: LocalParameter
units: 371312
value: 9.0E-17

689395
type: LocalParameter
units: 371397
value: 4.4999712E-15

372578
type: SpeciesReference
stoichiometry: 1.0
species: 738679

738679
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

372566
type: SpeciesReference
stoichiometry: 1.0
species: 739959

739959
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 737339

372554
type: SpeciesReference
stoichiometry: 1.0
species: 737399

743998
type: Reaction
kinetic law: 372784
product: 372772
reactant: 372760
notes: Diffusional equilibrium between PSD- and cytosolic compartment. According to D. Bary in Cell Movements 2nd ed 2001 D for proteins is 5e-7 cm^2/s giving 10 ms for a translocation of 1 um.
fast: false
reversible: true

372784
type: KineticLaw
local parameters: 689411
local parameters: 689410
notes: kf*CaM_minus_Ca4_minus_PSD-kb*CaM_minus_Ca4

689411
type: LocalParameter
units: 371312
value: 5.4E-15

689410
type: LocalParameter
units: 371312
value: 5.4E-15

372772
type: SpeciesReference
stoichiometry: 1.0
species: 737399

372760
type: SpeciesReference
stoichiometry: 1.0
species: 740259

744878
type: Reaction
kinetic law: 374794
product: 374782
product: 374770
reactant: 374758
fast: false
reversible: false

374794
type: KineticLaw
local parameters: 689531
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx

689531
type: LocalParameter
units: 371312
value: 5.4E-16

374782
type: SpeciesReference
stoichiometry: 1.0
species: 742618

374770
type: SpeciesReference
stoichiometry: 1.0
species: 737639

374758
type: SpeciesReference
stoichiometry: 1.0
species: 737719

749998
type: Reaction
kinetic law: 387218
product: 387206
product: 387194
reactant: 387182
fast: false
reversible: false

387218
type: KineticLaw
local parameters: 690123
notes: k3*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx

690123
type: LocalParameter
units: 371312
value: 6.0E-17

387206
type: SpeciesReference
stoichiometry: 1.0
species: 742918

387194
type: SpeciesReference
stoichiometry: 1.0
species: 741958

387182
type: SpeciesReference
stoichiometry: 1.0
species: 741999

741999
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

745938
type: Reaction
kinetic law: 377364
product: 377352
reactant: 377340
reactant: 377328
fast: false
reversible: true

377364
type: KineticLaw
local parameters: 689667
local parameters: 689665
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx

689667
type: LocalParameter
units: 371312
value: 7.2E-16

689665
type: LocalParameter
units: 371397
value: 2.011824E-17

377352
type: SpeciesReference
stoichiometry: 1.0
species: 738639

377340
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377328
type: SpeciesReference
stoichiometry: 1.0
species: 741719

739659
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

747158
type: Reaction
kinetic law: 380318
product: 380306
product: 380294
reactant: 380282
fast: false
reversible: false

380318
type: KineticLaw
local parameters: 689803
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx

689803
type: LocalParameter
units: 371312
value: 5.4E-16

380306
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380294
type: SpeciesReference
stoichiometry: 1.0
species: 741299

380282
type: SpeciesReference
stoichiometry: 1.0
species: 739479

748958
type: Reaction
kinetic law: 384683
product: 384671
product: 384658
reactant: 384646
fast: false
reversible: false

384683
type: KineticLaw
local parameters: 690007
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx

690007
type: LocalParameter
units: 371312
value: 1.7E-18

384671
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384658
type: SpeciesReference
stoichiometry: 1.0
species: 741779

384646
type: SpeciesReference
stoichiometry: 1.0
species: 740719

743478
type: Reaction
kinetic law: 371554
product: 371542
reactant: 371530
reactant: 371517
notes: Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
fast: false
reversible: true

371554
type: KineticLaw
local parameters: 689330
local parameters: 689329
notes: kf*CaMKII_slash_CaMKII_minus_thr286*CaM_minus_Ca4-kb*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM

689330
type: LocalParameter
units: 371312
value: 9.0E-18

689329
type: LocalParameter
units: 371397
value: 9.001692E-14

371542
type: SpeciesReference
stoichiometry: 1.0
species: 737619

371530
type: SpeciesReference
stoichiometry: 1.0
species: 737399

371517
type: SpeciesReference
stoichiometry: 1.0
species: 737659

746978
type: Reaction
kinetic law: 379884
product: 379872
reactant: 379860
reactant: 379847
fast: false
reversible: true

379884
type: KineticLaw
local parameters: 689784
local parameters: 689782
notes: k1*AMPAR_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx

689784
type: LocalParameter
units: 371312
value: 2.16E-15

689782
type: LocalParameter
units: 371397
value: 3.5998992E-16

379872
type: SpeciesReference
stoichiometry: 1.0
species: 739399

739399
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

379860
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379847
type: SpeciesReference
stoichiometry: 1.0
species: 741199

745758
type: Reaction
kinetic law: 376928
product: 376916
product: 376904
reactant: 376892
fast: false
reversible: false

376928
type: KineticLaw
local parameters: 689646
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx

689646
type: LocalParameter
units: 371312
value: 1.8E-16

376916
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376904
type: SpeciesReference
stoichiometry: 1.0
species: 741399

376892
type: SpeciesReference
stoichiometry: 1.0
species: 738539

746118
type: Reaction
kinetic law: 377800
product: 377788
product: 377776
reactant: 377764
fast: false
reversible: false

377800
type: KineticLaw
local parameters: 689686
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx

689686
type: LocalParameter
units: 371312
value: 1.8E-16

377788
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377776
type: SpeciesReference
stoichiometry: 1.0
species: 741739

377764
type: SpeciesReference
stoichiometry: 1.0
species: 738739

747298
type: Reaction
kinetic law: 380658
product: 380646
reactant: 380634
reactant: 380622
fast: false
reversible: true

380658
type: KineticLaw
local parameters: 689820
local parameters: 689818
notes: k1*AMPAR_slash_A845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx

689820
type: LocalParameter
units: 371312
value: 2.16E-15

689818
type: LocalParameter
units: 371397
value: 3.5998992E-16

380646
type: SpeciesReference
stoichiometry: 1.0
species: 739559

380634
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380622
type: SpeciesReference
stoichiometry: 1.0
species: 741239

744178
type: Reaction
kinetic law: 373193
product: 373181
reactant: 373169
fast: false
reversible: true

373193
type: KineticLaw
local parameters: 689438
local parameters: 689437
notes: kf*AMPAR_slash_A835_star_845_star__B835_star_845_star_-kb*AMPAR_slash_AMPAR_deg

689438
type: LocalParameter
units: 371312
value: 0.0

689437
type: LocalParameter
units: 371312
value: 3.24E-21

373181
type: SpeciesReference
stoichiometry: 1.0
species: 742478

373169
type: SpeciesReference
stoichiometry: 1.0
species: 741359

750258
type: Reaction
kinetic law: 387845
product: 387833
reactant: 387820
reactant: 387808
fast: false
reversible: true

387845
type: KineticLaw
local parameters: 690150
local parameters: 690148
notes: k1*AMPAR_memb_slash_A_B845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx

690150
type: LocalParameter
units: 371312
value: 2.0E-17

690148
type: LocalParameter
units: 371397
value: 2.77776E-19

387833
type: SpeciesReference
stoichiometry: 1.0
species: 742098

387820
type: SpeciesReference
stoichiometry: 1.0
species: 742978

387808
type: SpeciesReference
stoichiometry: 1.0
species: 741679

745318
type: Reaction
kinetic law: 375857
product: 375845
product: 375833
reactant: 375821
fast: false
reversible: false

375857
type: KineticLaw
local parameters: 689581
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx

689581
type: LocalParameter
units: 371312
value: 1.8E-16

375845
type: SpeciesReference
stoichiometry: 1.0
species: 738199

375833
type: SpeciesReference
stoichiometry: 1.0
species: 741199

375821
type: SpeciesReference
stoichiometry: 1.0
species: 738319

748438
type: Reaction
kinetic law: 383425
product: 383413
product: 383401
reactant: 383389
fast: false
reversible: false

383425
type: KineticLaw
local parameters: 689949
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx

689949
type: LocalParameter
units: 371312
value: 1.7E-18

383413
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383401
type: SpeciesReference
stoichiometry: 1.0
species: 741539

383389
type: SpeciesReference
stoichiometry: 1.0
species: 740459

748218
type: Reaction
kinetic law: 382891
product: 382879
reactant: 382867
reactant: 382855
notes: Rate is 1/6 of the CaM stim form. We\'ll just reduce all lf k1, k2, k3 so that the Vmax goes down 1/6.
fast: false
reversible: true

382891
type: KineticLaw
local parameters: 689925
local parameters: 689923
notes: k1*cAMP*AC_slash_PDE1-k2*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx

689925
type: LocalParameter
units: 371312
value: 6.003E-16

689923
type: LocalParameter
units: 371397
value: 1.8900054E-17

382879
type: SpeciesReference
stoichiometry: 1.0
species: 740139

382867
type: SpeciesReference
stoichiometry: 1.0
species: 740119

382855
type: SpeciesReference
stoichiometry: 1.0
species: 737539

750558
type: Reaction
kinetic law: 388571
product: 388559
product: 388547
reactant: 388534
fast: false
reversible: false

388571
type: KineticLaw
local parameters: 690179
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx

690179
type: LocalParameter
units: 371312
value: 5.0E-18

388559
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388547
type: SpeciesReference
stoichiometry: 1.0
species: 741839

388534
type: SpeciesReference
stoichiometry: 1.0
species: 742238

748058
type: Reaction
kinetic law: 382496
product: 382484
reactant: 382471
reactant: 382459
fast: false
reversible: true

382496
type: KineticLaw
local parameters: 689905
local parameters: 689904
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx

689905
type: LocalParameter
units: 371312
value: 2.16E-15

689904
type: LocalParameter
units: 371397
value: 3.999888E-17

382484
type: SpeciesReference
stoichiometry: 1.0
species: 739939

382471
type: SpeciesReference
stoichiometry: 1.0
species: 739239

382459
type: SpeciesReference
stoichiometry: 1.0
species: 741599

748018
type: Reaction
kinetic law: 382399
product: 382387
reactant: 382375
reactant: 382363
fast: false
reversible: true

382399
type: KineticLaw
local parameters: 689901
local parameters: 689899
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx

689901
type: LocalParameter
units: 371312
value: 2.16E-15

689899
type: LocalParameter
units: 371397
value: 3.999888E-17

382387
type: SpeciesReference
stoichiometry: 1.0
species: 739919

382375
type: SpeciesReference
stoichiometry: 1.0
species: 739239

382363
type: SpeciesReference
stoichiometry: 1.0
species: 741599

745818
type: Reaction
kinetic law: 377073
product: 377061
reactant: 377048
reactant: 377036
fast: false
reversible: true

377073
type: KineticLaw
local parameters: 689653
local parameters: 689652
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx

689653
type: LocalParameter
units: 371312
value: 7.2E-16

689652
type: LocalParameter
units: 371397
value: 1.8106416E-16

377061
type: SpeciesReference
stoichiometry: 1.0
species: 738579

377048
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377036
type: SpeciesReference
stoichiometry: 1.0
species: 741319

743718
type: Reaction
kinetic law: 372108
product: 372096
reactant: 372084
reactant: 372072
notes: This process is probably much more complicated and involves CaM. However, as I can\'t find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11
fast: false
reversible: true

372108
type: KineticLaw
local parameters: 689366
local parameters: 689365
notes: kf*Ca^2*PP2B_slash_CaNAB_minus_Ca2-kb*PP2B_slash_CaNAB_minus_Ca4

689366
type: LocalParameter
units: 371312
value: 9.0E-17

689365
type: LocalParameter
units: 371349
value: 3.24008424E-16

372096
type: SpeciesReference
stoichiometry: 1.0
species: 738999

372084
type: SpeciesReference
stoichiometry: 1.0
species: 738179

372072
type: SpeciesReference
stoichiometry: 2.0
species: 737559

749798
type: Reaction
kinetic law: 386735
product: 386723
product: 386711
reactant: 386699
fast: false
reversible: false

386735
type: KineticLaw
local parameters: 690102
notes: k3*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

690102
type: LocalParameter
units: 371312
value: 2.0E-18

386723
type: SpeciesReference
stoichiometry: 1.0
species: 741859

386711
type: SpeciesReference
stoichiometry: 1.0
species: 741979

386699
type: SpeciesReference
stoichiometry: 1.0
species: 741879

749578
type: Reaction
kinetic law: 386180
product: 386168
reactant: 386156
reactant: 386144
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

386180
type: KineticLaw
local parameters: 690078
local parameters: 690076
notes: k1*CaM_slash_neurogranin*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx

690078
type: LocalParameter
units: 371312
value: 2.106E-16

690076
type: LocalParameter
units: 371397
value: 9.180054E-18

386168
type: SpeciesReference
stoichiometry: 1.0
species: 741059

386156
type: SpeciesReference
stoichiometry: 1.0
species: 741039

386144
type: SpeciesReference
stoichiometry: 1.0
species: 737839

748618
type: Reaction
kinetic law: 383862
product: 383850
reactant: 383838
reactant: 383826
fast: false
reversible: true

383862
type: KineticLaw
local parameters: 689970
local parameters: 689968
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx

689970
type: LocalParameter
units: 371312
value: 1.4E-17

689968
type: LocalParameter
units: 371397
value: 8.7498E-18

383850
type: SpeciesReference
stoichiometry: 1.0
species: 740559

383838
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383826
type: SpeciesReference
stoichiometry: 1.0
species: 741799

746678
type: Reaction
kinetic law: 379156
product: 379143
product: 379131
reactant: 379119
fast: false
reversible: false

379156
type: KineticLaw
local parameters: 689749
notes: k3*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx

689749
type: LocalParameter
units: 371312
value: 3.06E-18

379143
type: SpeciesReference
stoichiometry: 1.0
species: 738999

379131
type: SpeciesReference
stoichiometry: 1.0
species: 740299

379119
type: SpeciesReference
stoichiometry: 1.0
species: 739039

739039
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

745458
type: Reaction
kinetic law: 376195
product: 376183
reactant: 376171
reactant: 376159
fast: false
reversible: true

376195
type: KineticLaw
local parameters: 689613
local parameters: 689611
notes: k1*AMPAR_slash_A_B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx

689613
type: LocalParameter
units: 371312
value: 7.2E-16

689611
type: LocalParameter
units: 371397
value: 1.8106416E-16

376183
type: SpeciesReference
stoichiometry: 1.0
species: 738399

376171
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376159
type: SpeciesReference
stoichiometry: 1.0
species: 741279

741279
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

749978
type: Reaction
kinetic law: 387170
product: 387158
reactant: 387146
reactant: 387134
fast: false
reversible: true

387170
type: KineticLaw
local parameters: 690122
local parameters: 690120
notes: k1*CaMKII_PSD_slash_CaMKII_minus_thr286_minus_PSD*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD-k2*CaMKII_PSD_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx

690122
type: LocalParameter
units: 371312
value: 2.4E-16

690120
type: LocalParameter
units: 371397
value: 9.375E-19

387158
type: SpeciesReference
stoichiometry: 1.0
species: 741999

387146
type: SpeciesReference
stoichiometry: 1.0
species: 742918

387134
type: SpeciesReference
stoichiometry: 1.0
species: 741978

747918
type: Reaction
kinetic law: 382158
product: 382146
product: 382134
reactant: 382122
fast: false
reversible: false

382158
type: KineticLaw
local parameters: 689889
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx

689889
type: LocalParameter
units: 371312
value: 5.4E-16

382146
type: SpeciesReference
stoichiometry: 1.0
species: 739239

382134
type: SpeciesReference
stoichiometry: 1.0
species: 741699

382122
type: SpeciesReference
stoichiometry: 1.0
species: 739859

739859
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

742418
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 737339

749518
type: Reaction
kinetic law: 386036
product: 386024
product: 386011
reactant: 385999
fast: false
reversible: false

386036
type: KineticLaw
local parameters: 690070
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx

690070
type: LocalParameter
units: 371312
value: 3.5E-18

386024
type: SpeciesReference
stoichiometry: 1.0
species: 740379

386011
type: SpeciesReference
stoichiometry: 1.0
species: 741639

385999
type: SpeciesReference
stoichiometry: 1.0
species: 740999

739819
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

749278
type: Reaction
kinetic law: 385455
product: 385443
product: 385431
reactant: 385419
fast: false
reversible: false

385455
type: KineticLaw
local parameters: 690043
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx

690043
type: LocalParameter
units: 371312
value: 3.5E-18

385443
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385431
type: SpeciesReference
stoichiometry: 1.0
species: 741819

385419
type: SpeciesReference
stoichiometry: 1.0
species: 740879

749238
type: Reaction
kinetic law: 385359
product: 385347
product: 385335
reactant: 385323
fast: false
reversible: false

385359
type: KineticLaw
local parameters: 690039
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx

690039
type: LocalParameter
units: 371312
value: 3.5E-18

385347
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385335
type: SpeciesReference
stoichiometry: 1.0
species: 741539

385323
type: SpeciesReference
stoichiometry: 1.0
species: 740859

746338
type: Reaction
kinetic law: 378333
product: 378321
reactant: 378309
reactant: 378296
fast: false
reversible: true

378333
type: KineticLaw
local parameters: 689712
local parameters: 689710
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx

689712
type: LocalParameter
units: 371312
value: 7.2E-16

689710
type: LocalParameter
units: 371397
value: 2.011824E-17

378321
type: SpeciesReference
stoichiometry: 1.0
species: 738859

738859
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

378309
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378296
type: SpeciesReference
stoichiometry: 1.0
species: 741759

745898
type: Reaction
kinetic law: 377266
product: 377254
reactant: 377242
reactant: 377230
fast: false
reversible: true

377266
type: KineticLaw
local parameters: 689662
local parameters: 689661
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx

689662
type: LocalParameter
units: 371312
value: 7.2E-16

689661
type: LocalParameter
units: 371397
value: 1.8106416E-16

377254
type: SpeciesReference
stoichiometry: 1.0
species: 738619

377242
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377230
type: SpeciesReference
stoichiometry: 1.0
species: 741359

749078
type: Reaction
kinetic law: 384973
product: 384960
product: 384948
reactant: 384936
fast: false
reversible: false

384973
type: KineticLaw
local parameters: 690021
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx

690021
type: LocalParameter
units: 371312
value: 1.7E-18

384960
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384948
type: SpeciesReference
stoichiometry: 1.0
species: 741599

384936
type: SpeciesReference
stoichiometry: 1.0
species: 740779

744118
type: Reaction
kinetic law: 373061
product: 373049
product: 373036
reactant: 373024
fast: false
reversible: true

373061
type: KineticLaw
local parameters: 689429
local parameters: 689428
notes: kf*AMPAR_memb_slash_A_B831_star_-kb*AMPAR_slash_A_B831_star_*Anchor

689429
type: LocalParameter
units: 371397
value: 0.0

689428
type: LocalParameter
units: 371312
value: 8.0E-21

373049
type: SpeciesReference
stoichiometry: 1.0
species: 741519

373036
type: SpeciesReference
stoichiometry: 1.0
species: 741419

373024
type: SpeciesReference
stoichiometry: 1.0
species: 741579

747698
type: Reaction
kinetic law: 381624
product: 381612
reactant: 381600
reactant: 381587
fast: false
reversible: true

381624
type: KineticLaw
local parameters: 689865
local parameters: 689863
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx

689865
type: LocalParameter
units: 371312
value: 2.16E-15

689863
type: LocalParameter
units: 371397
value: 3.999888E-17

381612
type: SpeciesReference
stoichiometry: 1.0
species: 739759

381600
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381587
type: SpeciesReference
stoichiometry: 1.0
species: 741559

746478
type: Reaction
kinetic law: 378672
product: 378660
product: 378648
reactant: 378636
fast: false
reversible: false

378672
type: KineticLaw
local parameters: 689727
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx

689727
type: LocalParameter
units: 371312
value: 1.8E-16

378660
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378648
type: SpeciesReference
stoichiometry: 1.0
species: 741659

378636
type: SpeciesReference
stoichiometry: 1.0
species: 738919

748838
type: Reaction
kinetic law: 384393
product: 384381
product: 384369
reactant: 384357
fast: false
reversible: false

384393
type: KineticLaw
local parameters: 689994
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx

689994
type: LocalParameter
units: 371312
value: 1.7E-18

384381
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384369
type: SpeciesReference
stoichiometry: 1.0
species: 741699

384357
type: SpeciesReference
stoichiometry: 1.0
species: 740659

744618
type: Reaction
kinetic law: 374161
product: 374148
reactant: 374136
reactant: 374124
fast: false
reversible: true

374161
type: KineticLaw
local parameters: 689503
local parameters: 689501
notes: k1*CaMKII_slash_CaMKII_minus_thr286*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

689503
type: LocalParameter
units: 371312
value: 9.0E-16

689501
type: LocalParameter
units: 371397
value: 2.2062942E-16

374148
type: SpeciesReference
stoichiometry: 1.0
species: 737459

374136
type: SpeciesReference
stoichiometry: 1.0
species: 737419

374124
type: SpeciesReference
stoichiometry: 1.0
species: 737659

746178
type: Reaction
kinetic law: 377945
product: 377933
reactant: 377921
reactant: 377908
fast: false
reversible: true

377945
type: KineticLaw
local parameters: 689694
local parameters: 689692
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx

689694
type: LocalParameter
units: 371312
value: 7.2E-16

689692
type: LocalParameter
units: 371397
value: 2.011824E-17

377933
type: SpeciesReference
stoichiometry: 1.0
species: 738779

377921
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377908
type: SpeciesReference
stoichiometry: 1.0
species: 741739

747978
type: Reaction
kinetic law: 382303
product: 382291
reactant: 382278
reactant: 382266
fast: false
reversible: true

382303
type: KineticLaw
local parameters: 689896
local parameters: 689895
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx

689896
type: LocalParameter
units: 371312
value: 2.16E-15

689895
type: LocalParameter
units: 371397
value: 3.999888E-17

382291
type: SpeciesReference
stoichiometry: 1.0
species: 739899

382278
type: SpeciesReference
stoichiometry: 1.0
species: 739239

382266
type: SpeciesReference
stoichiometry: 1.0
species: 741659

744558
type: Reaction
kinetic law: 374016
product: 374004
reactant: 373992
reactant: 373980
notes: Same as for transloc_1
fast: false
reversible: true

374016
type: KineticLaw
local parameters: 689495
local parameters: 689494
notes: kf*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*CaMKII_PSD_slash_NMDAR-kb*CaMKII_PSD_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD

689495
type: LocalParameter
units: 371312
value: 0.0

689494
type: LocalParameter
units: 371397
value: 1.08E-20

374004
type: SpeciesReference
stoichiometry: 1.0
species: 741998

373992
type: SpeciesReference
stoichiometry: 1.0
species: 742398

373980
type: SpeciesReference
stoichiometry: 1.0
species: 737619

742498
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 737339

740599
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

744398
type: Reaction
kinetic law: 373642
product: 373629
reactant: 373617
notes: Represents both synthesis and degradation of the receptor. The rate is set to be rather fast for now. The forward rate also includes scaling terms because the AMPAR_bulk is in the dendritic volume of 5e-18. This means that we need to lower Kf to account for the difference in volumes. Effectively Kf is 1/sec, but the scaled version becomes 9e-20/5e-18 = 0.018
fast: false
reversible: true

373642
type: KineticLaw
local parameters: 689471
local parameters: 689470
notes: kf*AMPAR_bulk-kb*AMPAR_slash_A_B

689471
type: LocalParameter
units: 371312
value: 9.0E-17

689470
type: LocalParameter
units: 371312
value: 9.0E-17

373629
type: SpeciesReference
stoichiometry: 1.0
species: 741199

373617
type: SpeciesReference
stoichiometry: 1.0
species: 742558

745138
type: Reaction
kinetic law: 375424
product: 375412
reactant: 375400
reactant: 375388
fast: false
reversible: true

375424
type: KineticLaw
local parameters: 689561
local parameters: 689560
notes: k1*PP1_slash_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx

689561
type: LocalParameter
units: 371312
value: 1.224E-16

689560
type: LocalParameter
units: 371397
value: 3.0779838E-17

375412
type: SpeciesReference
stoichiometry: 1.0
species: 738239

375400
type: SpeciesReference
stoichiometry: 1.0
species: 738199

375388
type: SpeciesReference
stoichiometry: 1.0
species: 737999

748678
type: Reaction
kinetic law: 384007
product: 383994
product: 383982
reactant: 383970
fast: false
reversible: false

384007
type: KineticLaw
local parameters: 689976
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx

689976
type: LocalParameter
units: 371312
value: 3.5E-18

383994
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383982
type: SpeciesReference
stoichiometry: 1.0
species: 741679

383970
type: SpeciesReference
stoichiometry: 1.0
species: 740579

740579
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

744698
type: Reaction
kinetic law: 374355
product: 374343
reactant: 374331
reactant: 374319
fast: false
reversible: true

374355
type: KineticLaw
local parameters: 689512
local parameters: 689510
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

689512
type: LocalParameter
units: 371312
value: 9.0E-16

689510
type: LocalParameter
units: 371397
value: 2.2062942E-16

374343
type: SpeciesReference
stoichiometry: 1.0
species: 737499

374331
type: SpeciesReference
stoichiometry: 1.0
species: 737419

374319
type: SpeciesReference
stoichiometry: 1.0
species: 737639

749858
type: Reaction
kinetic law: 386880
product: 386868
reactant: 386855
reactant: 386843
fast: false
reversible: true

386880
type: KineticLaw
local parameters: 690109
local parameters: 690108
notes: k1*CaMKII_PSD_slash_CaMKII_star__star__star__minus_PSD*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD-k2*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

690109
type: LocalParameter
units: 371312
value: 8.0E-18

690108
type: LocalParameter
units: 371397
value: 4.99998E-18

386868
type: SpeciesReference
stoichiometry: 1.0
species: 741918

386855
type: SpeciesReference
stoichiometry: 1.0
species: 741859

386843
type: SpeciesReference
stoichiometry: 1.0
species: 741958

743958
type: Reaction
kinetic law: 372711
product: 372699
reactant: 372687
reactant: 372675
notes: For olf epi PDE1, affinity is 7 nM. Assume same for brain. Reaction should be pretty fast. Assume kb = 5/sec. Then kf = 5 / (0.007 * 6e5) = 1.2e-3
fast: false
reversible: true

372711
type: KineticLaw
local parameters: 689405
local parameters: 689404
notes: kf*AC_slash_PDE1*CaM_minus_Ca4-kb*AC_slash_CaM_dot_PDE1

689405
type: LocalParameter
units: 371312
value: 4.5E-16

689404
type: LocalParameter
units: 371397
value: 6.479838E-14

372699
type: SpeciesReference
stoichiometry: 1.0
species: 740159

372687
type: SpeciesReference
stoichiometry: 1.0
species: 737399

372675
type: SpeciesReference
stoichiometry: 1.0
species: 740119

744838
type: Reaction
kinetic law: 374698
product: 374686
product: 374674
reactant: 374661
fast: false
reversible: false

374698
type: KineticLaw
local parameters: 689527
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx

689527
type: LocalParameter
units: 371312
value: 4.5E-17

374686
type: SpeciesReference
stoichiometry: 1.0
species: 742598

374674
type: SpeciesReference
stoichiometry: 1.0
species: 737619

374661
type: SpeciesReference
stoichiometry: 1.0
species: 737699

747638
type: Reaction
kinetic law: 381479
product: 381467
product: 381455
reactant: 381443
fast: false
reversible: false

381479
type: KineticLaw
local parameters: 689857
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx

689857
type: LocalParameter
units: 371312
value: 5.4E-16

381467
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381455
type: SpeciesReference
stoichiometry: 1.0
species: 741799

381443
type: SpeciesReference
stoichiometry: 1.0
species: 739719

742678
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

745698
type: Reaction
kinetic law: 376784
product: 376772
reactant: 376760
reactant: 376748
fast: false
reversible: true

376784
type: KineticLaw
local parameters: 689640
local parameters: 689638
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx

689640
type: LocalParameter
units: 371312
value: 7.2E-16

689638
type: LocalParameter
units: 371397
value: 1.8106416E-16

376772
type: SpeciesReference
stoichiometry: 1.0
species: 738519

738519
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

376760
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376748
type: SpeciesReference
stoichiometry: 1.0
species: 741339

745658
type: Reaction
kinetic law: 376687
product: 376675
reactant: 376663
reactant: 376651
fast: false
reversible: true

376687
type: KineticLaw
local parameters: 689635
local parameters: 689634
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx

689635
type: LocalParameter
units: 371312
value: 7.2E-16

689634
type: LocalParameter
units: 371397
value: 1.8106416E-16

376675
type: SpeciesReference
stoichiometry: 1.0
species: 738499

376663
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376651
type: SpeciesReference
stoichiometry: 1.0
species: 741319

737439
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

748918
type: Reaction
kinetic law: 384585
product: 384573
product: 384561
reactant: 384549
fast: false
reversible: false

384585
type: KineticLaw
local parameters: 690003
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx

690003
type: LocalParameter
units: 371312
value: 1.7E-18

384573
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384561
type: SpeciesReference
stoichiometry: 1.0
species: 741579

384549
type: SpeciesReference
stoichiometry: 1.0
species: 740699

746938
type: Reaction
kinetic law: 379787
product: 379775
reactant: 379763
reactant: 379751
fast: false
reversible: true

379787
type: KineticLaw
local parameters: 689779
local parameters: 689778
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx

689779
type: LocalParameter
units: 371312
value: 2.16E-15

689778
type: LocalParameter
units: 371397
value: 3.5998992E-16

379775
type: SpeciesReference
stoichiometry: 1.0
species: 739379

739379
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

379763
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379751
type: SpeciesReference
stoichiometry: 1.0
species: 741459

748998
type: Reaction
kinetic law: 384779
product: 384767
product: 384755
reactant: 384743
fast: false
reversible: false

384779
type: KineticLaw
local parameters: 690012
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx

690012
type: LocalParameter
units: 371312
value: 1.7E-18

384767
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384755
type: SpeciesReference
stoichiometry: 1.0
species: 741659

384743
type: SpeciesReference
stoichiometry: 1.0
species: 740739

745718
type: Reaction
kinetic law: 376832
product: 376820
product: 376808
reactant: 376796
fast: false
reversible: false

376832
type: KineticLaw
local parameters: 689641
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx

689641
type: LocalParameter
units: 371312
value: 1.8E-16

376820
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376808
type: SpeciesReference
stoichiometry: 1.0
species: 741379

376796
type: SpeciesReference
stoichiometry: 1.0
species: 738519

748338
type: Reaction
kinetic law: 383184
product: 383172
reactant: 383160
reactant: 383147
fast: false
reversible: true

383184
type: KineticLaw
local parameters: 689938
local parameters: 689937
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx

689938
type: LocalParameter
units: 371312
value: 6.8E-18

689937
type: LocalParameter
units: 371397
value: 8.7498E-18

383172
type: SpeciesReference
stoichiometry: 1.0
species: 740419

383160
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383147
type: SpeciesReference
stoichiometry: 1.0
species: 741719

745798
type: Reaction
kinetic law: 377024
product: 377012
product: 377000
reactant: 376988
fast: false
reversible: false

377024
type: KineticLaw
local parameters: 689650
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx

689650
type: LocalParameter
units: 371312
value: 1.8E-16

377012
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377000
type: SpeciesReference
stoichiometry: 1.0
species: 741239

376988
type: SpeciesReference
stoichiometry: 1.0
species: 738559

743618
type: Reaction
kinetic law: 371879
product: 371867
reactant: 371855
reactant: 371843
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true

371879
type: KineticLaw
local parameters: 689351
local parameters: 689350
notes: kf*CaM_minus_Ca3_minus_PSD*Ca_minus_PSD-kb*CaM_minus_Ca4_minus_PSD

689351
type: LocalParameter
units: 371312
value: 1.0E-16

689350
type: LocalParameter
units: 371397
value: 4.65012E-18

371867
type: SpeciesReference
stoichiometry: 1.0
species: 740259

371855
type: SpeciesReference
stoichiometry: 1.0
species: 740279

371843
type: SpeciesReference
stoichiometry: 1.0
species: 740239

743658
type: Reaction
kinetic law: 371963
product: 371951
reactant: 371939
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true

371963
type: KineticLaw
local parameters: 689357
local parameters: 689356
notes: kf*CaM_slash_neurogranin_star__PSD-kb*CaM_slash_neurogranin_PSD

689357
type: LocalParameter
units: 371312
value: 0.0

689356
type: LocalParameter
units: 371312
value: 5.0E-20

371951
type: SpeciesReference
stoichiometry: 1.0
species: 737899

371939
type: SpeciesReference
stoichiometry: 1.0
species: 737919

750298
type: Reaction
kinetic law: 387941
product: 387929
reactant: 387917
reactant: 387905
fast: false
reversible: true

387941
type: KineticLaw
local parameters: 690154
local parameters: 690152
notes: k1*AMPAR_memb_slash_A845_star__B*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx

690154
type: LocalParameter
units: 371312
value: 2.0E-17

690152
type: LocalParameter
units: 371397
value: 2.77776E-19

387929
type: SpeciesReference
stoichiometry: 1.0
species: 742118

387917
type: SpeciesReference
stoichiometry: 1.0
species: 742978

387905
type: SpeciesReference
stoichiometry: 1.0
species: 741619

748518
type: Reaction
kinetic law: 383620
product: 383608
product: 383596
reactant: 383584
fast: false
reversible: false

383620
type: KineticLaw
local parameters: 689958
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx

689958
type: LocalParameter
units: 371312
value: 1.7E-18

383608
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383596
type: SpeciesReference
stoichiometry: 1.0
species: 741639

383584
type: SpeciesReference
stoichiometry: 1.0
species: 740499

748478
type: Reaction
kinetic law: 383524
product: 383511
product: 383499
reactant: 383487
fast: false
reversible: false

383524
type: KineticLaw
local parameters: 689953
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx

689953
type: LocalParameter
units: 371312
value: 1.7E-18

383511
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383499
type: SpeciesReference
stoichiometry: 1.0
species: 741739

383487
type: SpeciesReference
stoichiometry: 1.0
species: 740479

748258
type: Reaction
kinetic law: 382988
product: 382975
reactant: 382963
reactant: 382951
notes: Max activity ~10umol/min/mg in presence of lots of CaM. Affinity is low, 40 uM. k3 = 10, k2 = 40, k1 = (50/40) / 6e5.
fast: false
reversible: true

382988
type: KineticLaw
local parameters: 689929
local parameters: 689928
notes: k1*cAMP*AC_slash_CaM_dot_PDE1-k2*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx

689929
type: LocalParameter
units: 371312
value: 3.6E-15

689928
type: LocalParameter
units: 371397
value: 1.1339838E-16

382975
type: SpeciesReference
stoichiometry: 1.0
species: 740179

382963
type: SpeciesReference
stoichiometry: 1.0
species: 740159

382951
type: SpeciesReference
stoichiometry: 1.0
species: 737539

745358
type: Reaction
kinetic law: 375953
product: 375941
product: 375929
reactant: 375917
fast: false
reversible: false

375953
type: KineticLaw
local parameters: 689601
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx

689601
type: LocalParameter
units: 371312
value: 1.8E-16

375941
type: SpeciesReference
stoichiometry: 1.0
species: 738199

375929
type: SpeciesReference
stoichiometry: 1.0
species: 741219

375917
type: SpeciesReference
stoichiometry: 1.0
species: 738339

738339
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

739099
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

743458
type: Reaction
kinetic law: 371505
product: 371493
reactant: 371481
reactant: 371469
notes: This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
fast: false
reversible: true

371505
type: KineticLaw
local parameters: 689327
local parameters: 689326
notes: kf*CaM_minus_Ca4*CaMKII_slash_CaMKII-kb*CaMKII_slash_CaMKII_minus_CaM

689327
type: LocalParameter
units: 371312
value: 4.5E-16

689326
type: LocalParameter
units: 371397
value: 4.4999712E-15

371493
type: SpeciesReference
stoichiometry: 1.0
species: 737599

371481
type: SpeciesReference
stoichiometry: 1.0
species: 737579

371469
type: SpeciesReference
stoichiometry: 1.0
species: 737399

748098
type: Reaction
kinetic law: 382598
modifier: 382585
product: 382572
reactant: 382559
notes: 17 Feb 2005 Halved Vmax as the amount of enzyme has been doubled to get an integer value in the spine. 18 Feb 2005. Updated Km from BRENDA: EC No 4.6.1.1 Rat Km: 0.95 mM Turnover 12/sec. Human Km: 0.3 mM 12 umol/min/mg for mammalia, turnover is 12/sec See PMID 8663304 by Dessauer and Gilman JBC 271 1996 Unfortunately turnover range is from 34 down to 0.1 in different studies, according to BRENDA.
fast: false
reversible: false

382598
type: KineticLaw
local parameters: 689910
local parameters: 689908
notes: kcat*AC_slash_AC1_minus_CaM*AC_slash_ATP/(Km+AC_slash_ATP)

689910
type: LocalParameter
units: 371276
value: 299.9976000192

689908
type: LocalParameter
units: 371312
value: 4.05E-16

382572
type: SpeciesReference
stoichiometry: 1.0
species: 737539

382559
type: SpeciesReference
stoichiometry: 1.0
species: 742438

743758
type: Reaction
kinetic law: 372204
product: 372192
reactant: 372180
reactant: 372168
fast: false
reversible: true

372204
type: KineticLaw
local parameters: 689372
local parameters: 689371
notes: kf*CaM_minus_Ca4*PP2B_slash_CaNAB_minus_Ca4-kb*PP2B_slash_CaM_Ca_n_minus_CaNAB

689372
type: LocalParameter
units: 371312
value: 9.0E-17

689371
type: LocalParameter
units: 371397
value: 5.399946E-14

372192
type: SpeciesReference
stoichiometry: 1.0
species: 738199

372180
type: SpeciesReference
stoichiometry: 1.0
species: 738999

372168
type: SpeciesReference
stoichiometry: 1.0
species: 737399

743798
type: Reaction
kinetic law: 372301
product: 372289
reactant: 372277
reactant: 372265
notes: For now let us set this to the same Km (1e-7M) as site B. This gives kf/kb = .7e-7M * 1e6 / (6e5^2) : 1/(6e5^2) = 2e-13:2.77e-12 Smith et al have better values. They say that this is cooperative, so the consts are now kf/kb =8.3e-4
fast: false
reversible: true

372301
type: KineticLaw
local parameters: 689378
local parameters: 689377
notes: kf*PKA_slash_R2C2_minus_cAMP*cAMP-kb*PKA_slash_R2C2_minus_cAMP2

689378
type: LocalParameter
units: 371312
value: 2.97E-15

689377
type: LocalParameter
units: 371397
value: 4.86E-15

372289
type: SpeciesReference
stoichiometry: 1.0
species: 739099

372277
type: SpeciesReference
stoichiometry: 1.0
species: 737539

372265
type: SpeciesReference
stoichiometry: 1.0
species: 739079

748658
type: Reaction
kinetic law: 383958
product: 383946
reactant: 383934
reactant: 383922
fast: false
reversible: true

383958
type: KineticLaw
local parameters: 689974
local parameters: 689973
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx

689974
type: LocalParameter
units: 371312
value: 1.4E-17

689973
type: LocalParameter
units: 371397
value: 8.7498E-18

383946
type: SpeciesReference
stoichiometry: 1.0
species: 740579

383934
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383922
type: SpeciesReference
stoichiometry: 1.0
species: 741739

745498
type: Reaction
kinetic law: 376292
product: 376280
reactant: 376268
reactant: 376256
fast: false
reversible: true

376292
type: KineticLaw
local parameters: 689617
local parameters: 689616
notes: k1*AMPAR_slash_A831_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx

689617
type: LocalParameter
units: 371312
value: 7.2E-16

689616
type: LocalParameter
units: 371397
value: 1.8106416E-16

376280
type: SpeciesReference
stoichiometry: 1.0
species: 738419

376268
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376256
type: SpeciesReference
stoichiometry: 1.0
species: 741499

750738
type: Reaction
kinetic law: 389008
product: 388996
reactant: 388984
reactant: 388972
fast: false
reversible: true

389008
type: KineticLaw
local parameters: 690198
local parameters: 690196
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx

690198
type: LocalParameter
units: 371312
value: 2.0E-17

690196
type: LocalParameter
units: 371397
value: 2.77776E-19

388996
type: SpeciesReference
stoichiometry: 1.0
species: 742338

388984
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388972
type: SpeciesReference
stoichiometry: 1.0
species: 741739

747858
type: Reaction
kinetic law: 382014
product: 382002
reactant: 381989
reactant: 381977
fast: false
reversible: true

382014
type: KineticLaw
local parameters: 689883
local parameters: 689881
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx

689883
type: LocalParameter
units: 371312
value: 2.16E-15

689881
type: LocalParameter
units: 371397
value: 3.999888E-17

382002
type: SpeciesReference
stoichiometry: 1.0
species: 739839

381989
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381977
type: SpeciesReference
stoichiometry: 1.0
species: 741579

747198
type: Reaction
kinetic law: 380415
product: 380403
product: 380391
reactant: 380379
fast: false
reversible: false

380415
type: KineticLaw
local parameters: 689808
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx

689808
type: LocalParameter
units: 371312
value: 5.4E-16

380403
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380391
type: SpeciesReference
stoichiometry: 1.0
species: 741319

380379
type: SpeciesReference
stoichiometry: 1.0
species: 739499

744818
type: Reaction
kinetic law: 374649
product: 374637
reactant: 374624
reactant: 374612
fast: false
reversible: true

374649
type: KineticLaw
local parameters: 689525
local parameters: 689524
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx

689525
type: LocalParameter
units: 371312
value: 1.8E-16

689524
type: LocalParameter
units: 371397
value: 9.91197E-19

374637
type: SpeciesReference
stoichiometry: 1.0
species: 737699

374624
type: SpeciesReference
stoichiometry: 1.0
species: 742598

374612
type: SpeciesReference
stoichiometry: 1.0
species: 737599

749098
type: Reaction
kinetic law: 385021
product: 385009
reactant: 384997
reactant: 384985
fast: false
reversible: true

385021
type: KineticLaw
local parameters: 690024
local parameters: 690022
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx

690024
type: LocalParameter
units: 371312
value: 1.4E-17

690022
type: LocalParameter
units: 371397
value: 8.7498E-18

385009
type: SpeciesReference
stoichiometry: 1.0
species: 740799

384997
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384985
type: SpeciesReference
stoichiometry: 1.0
species: 741759

745018
type: Reaction
kinetic law: 375132
product: 375120
reactant: 375108
reactant: 375096
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true

375132
type: KineticLaw
local parameters: 689548
local parameters: 689546
notes: k1*PP1_PSD_slash_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx

689548
type: LocalParameter
units: 371312
value: 7.50006E-16

689546
type: LocalParameter
units: 371397
value: 6.4584E-18

375120
type: SpeciesReference
stoichiometry: 1.0
species: 738119

375108
type: SpeciesReference
stoichiometry: 1.0
species: 738059

375096
type: SpeciesReference
stoichiometry: 1.0
species: 740319

749558
type: Reaction
kinetic law: 386132
product: 386120
product: 386108
reactant: 386096
fast: false
reversible: false

386132
type: KineticLaw
local parameters: 690075
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx

690075
type: LocalParameter
units: 371312
value: 3.5E-18

386120
type: SpeciesReference
stoichiometry: 1.0
species: 740379

386108
type: SpeciesReference
stoichiometry: 1.0
species: 741559

386096
type: SpeciesReference
stoichiometry: 1.0
species: 741019

747138
type: Reaction
kinetic law: 380270
product: 380258
reactant: 380246
reactant: 380234
fast: false
reversible: true

380270
type: KineticLaw
local parameters: 689802
local parameters: 689800
notes: k1*AMPAR_slash_A_B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx

689802
type: LocalParameter
units: 371312
value: 2.16E-15

689800
type: LocalParameter
units: 371397
value: 3.5998992E-16

380258
type: SpeciesReference
stoichiometry: 1.0
species: 739479

380246
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380234
type: SpeciesReference
stoichiometry: 1.0
species: 741279

745198
type: Reaction
kinetic law: 375568
product: 375556
product: 375544
reactant: 375532
fast: false
reversible: false

375568
type: KineticLaw
local parameters: 689567
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx

689567
type: LocalParameter
units: 371312
value: 3.06E-17

375556
type: SpeciesReference
stoichiometry: 1.0
species: 738199

375544
type: SpeciesReference
stoichiometry: 1.0
species: 738039

375532
type: SpeciesReference
stoichiometry: 1.0
species: 738259

746958
type: Reaction
kinetic law: 379835
product: 379823
product: 379811
reactant: 379799
fast: false
reversible: false

379835
type: KineticLaw
local parameters: 689781
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx

689781
type: LocalParameter
units: 371312
value: 5.4E-16

379823
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379811
type: SpeciesReference
stoichiometry: 1.0
species: 741479

379799
type: SpeciesReference
stoichiometry: 1.0
species: 739379

746378
type: Reaction
kinetic law: 378429
product: 378417
reactant: 378405
reactant: 378393
fast: false
reversible: true

378429
type: KineticLaw
local parameters: 689716
local parameters: 689715
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx

689716
type: LocalParameter
units: 371312
value: 7.2E-16

689715
type: LocalParameter
units: 371397
value: 2.011824E-17

378417
type: SpeciesReference
stoichiometry: 1.0
species: 738879

378405
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378393
type: SpeciesReference
stoichiometry: 1.0
species: 741699

750478
type: Reaction
kinetic law: 388376
product: 388364
product: 388352
reactant: 388340
fast: false
reversible: false

388376
type: KineticLaw
local parameters: 690171
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx

690171
type: LocalParameter
units: 371312
value: 5.0E-18

388364
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388352
type: SpeciesReference
stoichiometry: 1.0
species: 741699

388340
type: SpeciesReference
stoichiometry: 1.0
species: 742198

749118
type: Reaction
kinetic law: 385069
product: 385057
product: 385045
reactant: 385033
fast: false
reversible: false

385069
type: KineticLaw
local parameters: 690025
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx

690025
type: LocalParameter
units: 371312
value: 3.5E-18

385057
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385045
type: SpeciesReference
stoichiometry: 1.0
species: 741679

385033
type: SpeciesReference
stoichiometry: 1.0
species: 740799

744158
type: Reaction
kinetic law: 373157
product: 373145
product: 373133
reactant: 373121
fast: false
reversible: true

373157
type: KineticLaw
local parameters: 689435
local parameters: 689434
notes: kf*AMPAR_memb_slash_A_B-kb*AMPAR_slash_A_B*Anchor

689435
type: LocalParameter
units: 371397
value: 0.0

689434
type: LocalParameter
units: 371312
value: 8.0E-21

373145
type: SpeciesReference
stoichiometry: 1.0
species: 741519

373133
type: SpeciesReference
stoichiometry: 1.0
species: 741199

373121
type: SpeciesReference
stoichiometry: 1.0
species: 741539

746518
type: Reaction
kinetic law: 378769
product: 378757
product: 378744
reactant: 378732
fast: false
reversible: false

378769
type: KineticLaw
local parameters: 689731
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx

689731
type: LocalParameter
units: 371312
value: 1.8E-16

378757
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378744
type: SpeciesReference
stoichiometry: 1.0
species: 741599

378732
type: SpeciesReference
stoichiometry: 1.0
species: 738939

748878
type: Reaction
kinetic law: 384489
product: 384477
product: 384465
reactant: 384453
fast: false
reversible: false

384489
type: KineticLaw
local parameters: 689998
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx

689998
type: LocalParameter
units: 371312
value: 1.7E-18

384477
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384465
type: SpeciesReference
stoichiometry: 1.0
species: 741579

384453
type: SpeciesReference
stoichiometry: 1.0
species: 740679

750538
type: Reaction
kinetic law: 388521
product: 388509
reactant: 388497
reactant: 388485
fast: false
reversible: true

388521
type: KineticLaw
local parameters: 690178
local parameters: 690176
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx

690178
type: LocalParameter
units: 371312
value: 2.0E-17

690176
type: LocalParameter
units: 371397
value: 2.77776E-19

388509
type: SpeciesReference
stoichiometry: 1.0
species: 742238

388497
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388485
type: SpeciesReference
stoichiometry: 1.0
species: 741819

749258
type: Reaction
kinetic law: 385407
product: 385395
reactant: 385383
reactant: 385371
fast: false
reversible: true

385407
type: KineticLaw
local parameters: 690042
local parameters: 690040
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx

690042
type: LocalParameter
units: 371312
value: 1.4E-17

690040
type: LocalParameter
units: 371397
value: 8.7498E-18

385395
type: SpeciesReference
stoichiometry: 1.0
species: 740879

385383
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385371
type: SpeciesReference
stoichiometry: 1.0
species: 741839

749218
type: Reaction
kinetic law: 385311
product: 385299
reactant: 385287
reactant: 385275
fast: false
reversible: true

385311
type: KineticLaw
local parameters: 690037
local parameters: 690036
notes: k1*AMPAR_memb_slash_A_B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx

690037
type: LocalParameter
units: 371312
value: 1.4E-17

690036
type: LocalParameter
units: 371397
value: 8.7498E-18

385299
type: SpeciesReference
stoichiometry: 1.0
species: 740859

385287
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385275
type: SpeciesReference
stoichiometry: 1.0
species: 741579

746318
type: Reaction
kinetic law: 378284
product: 378272
product: 378260
reactant: 378248
fast: false
reversible: false

378284
type: KineticLaw
local parameters: 689709
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx

689709
type: LocalParameter
units: 371312
value: 1.8E-16

378272
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378260
type: SpeciesReference
stoichiometry: 1.0
species: 741699

378248
type: SpeciesReference
stoichiometry: 1.0
species: 738839

745878
type: Reaction
kinetic law: 377218
product: 377206
product: 377194
reactant: 377182
fast: false
reversible: false

377218
type: KineticLaw
local parameters: 689659
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx

689659
type: LocalParameter
units: 371312
value: 1.8E-16

377206
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377194
type: SpeciesReference
stoichiometry: 1.0
species: 741439

377182
type: SpeciesReference
stoichiometry: 1.0
species: 738599

746658
type: Reaction
kinetic law: 379107
product: 379095
reactant: 379083
reactant: 379071
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true

379107
type: KineticLaw
local parameters: 689748
local parameters: 689746
notes: k1*PP1_PSD_slash_I1_star_*PP2B_slash_CaNAB_minus_Ca4-k2*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx

689748
type: LocalParameter
units: 371312
value: 1.224E-17

689746
type: LocalParameter
units: 371397
value: 3.420036E-19

379095
type: SpeciesReference
stoichiometry: 1.0
species: 739039

379083
type: SpeciesReference
stoichiometry: 1.0
species: 738999

379071
type: SpeciesReference
stoichiometry: 1.0
species: 740319

742778
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

750178
type: Reaction
kinetic law: 387652
product: 387640
reactant: 387628
reactant: 387616
fast: false
reversible: true

387652
type: KineticLaw
local parameters: 690142
local parameters: 690140
notes: k1*CaMKII_PSD_slash_CaMKII_minus_PSD*CaMKII_PSD_slash_tot_minus_auto_minus_PSD-k2*CaMKII_PSD_slash_tot_minus_auto_minus_PSD_slash_auton_minus_autoph_slash_auton_minus_autoph_cplx

690142
type: LocalParameter
units: 371312
value: 8.0E-17

690140
type: LocalParameter
units: 371397
value: 1.99998E-19

387640
type: SpeciesReference
stoichiometry: 1.0
species: 742058

387628
type: SpeciesReference
stoichiometry: 1.0
species: 742938

387616
type: SpeciesReference
stoichiometry: 1.0
species: 741959

744518
type: Reaction
kinetic law: 373920
product: 373908
product: 373895
reactant: 373883
notes: Rates set by the translocation experiments of Shen and Meyer, Science 1999. Note that this reaction also incorporates a translocation between compartments of different volumes.
fast: false
reversible: true

373920
type: KineticLaw
local parameters: 689489
local parameters: 689488
notes: kf*CaMKII_PSD_slash_CaMKII_minus_PSD-kb*CaMKII_slash_CaMKII*CaMKII_PSD_slash_NMDAR

689489
type: LocalParameter
units: 371397
value: 5.4E-21

689488
type: LocalParameter
units: 371312
value: 3.0E-18

373908
type: SpeciesReference
stoichiometry: 1.0
species: 742398

373895
type: SpeciesReference
stoichiometry: 1.0
species: 737579

373883
type: SpeciesReference
stoichiometry: 1.0
species: 741959

747358
type: Reaction
kinetic law: 380803
product: 380791
product: 380779
reactant: 380767
fast: false
reversible: false

380803
type: KineticLaw
local parameters: 689826
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx

689826
type: LocalParameter
units: 371312
value: 5.4E-16

380791
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380779
type: SpeciesReference
stoichiometry: 1.0
species: 741319

380767
type: SpeciesReference
stoichiometry: 1.0
species: 739579

739579
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

744598
type: Reaction
kinetic law: 374112
product: 374100
product: 374088
reactant: 374076
fast: false
reversible: false

374112
type: KineticLaw
local parameters: 689500
notes: k3*PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

689500
type: LocalParameter
units: 371312
value: 2.25E-16

374100
type: SpeciesReference
stoichiometry: 1.0
species: 737419

374088
type: SpeciesReference
stoichiometry: 1.0
species: 737599

374076
type: SpeciesReference
stoichiometry: 1.0
species: 737439

743939
type: Reaction
kinetic law: 372662
product: 372650
reactant: 372638
notes: The rates for this are poorly constrained. In adipocytes (probably a different PDE) the dephosphorylation is complete within 15 min, but there are no intermediate time points so it could be much faster. Identity of phosphatase etc is still unknown.
fast: false
reversible: true

372662
type: KineticLaw
local parameters: 689402
local parameters: 689401
notes: kf*AC_slash_cAMP_minus_PDE_star_-kb*AC_slash_cAMP_minus_PDE

689402
type: LocalParameter
units: 371312
value: 0.0

689401
type: LocalParameter
units: 371312
value: 9.0E-19

372650
type: SpeciesReference
stoichiometry: 1.0
species: 740039

372638
type: SpeciesReference
stoichiometry: 1.0
species: 740079

745178
type: Reaction
kinetic law: 375520
product: 375508
reactant: 375496
reactant: 375484
fast: false
reversible: true

375520
type: KineticLaw
local parameters: 689566
local parameters: 689564
notes: k1*PP1_slash_PP1_minus_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx

689566
type: LocalParameter
units: 371312
value: 1.224E-16

689564
type: LocalParameter
units: 371397
value: 3.0779838E-17

375508
type: SpeciesReference
stoichiometry: 1.0
species: 738259

375496
type: SpeciesReference
stoichiometry: 1.0
species: 738199

375484
type: SpeciesReference
stoichiometry: 1.0
species: 738019

747538
type: Reaction
kinetic law: 381238
product: 381226
reactant: 381214
reactant: 381202
fast: false
reversible: true

381238
type: KineticLaw
local parameters: 689847
local parameters: 689845
notes: k1*AMPAR_memb_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx

689847
type: LocalParameter
units: 371312
value: 2.16E-15

689845
type: LocalParameter
units: 371397
value: 3.999888E-17

381226
type: SpeciesReference
stoichiometry: 1.0
species: 739679

381214
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381202
type: SpeciesReference
stoichiometry: 1.0
species: 741539

747498
type: Reaction
kinetic law: 381141
product: 381129
reactant: 381117
reactant: 381105
fast: false
reversible: true

381141
type: KineticLaw
local parameters: 689842
local parameters: 689841
notes: k1*AMPAR_memb_slash_A845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx

689842
type: LocalParameter
units: 371312
value: 2.16E-15

689841
type: LocalParameter
units: 371397
value: 3.999888E-17

381129
type: SpeciesReference
stoichiometry: 1.0
species: 739659

381117
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381105
type: SpeciesReference
stoichiometry: 1.0
species: 741619

744338
type: Reaction
kinetic law: 373532
product: 373519
reactant: 373507
fast: false
reversible: true

373532
type: KineticLaw
local parameters: 689462
local parameters: 689461
notes: kf*PKC_minus_control-kb*PKC_minus_active

689462
type: LocalParameter
units: 371312
value: 2.25E-16

689461
type: LocalParameter
units: 371312
value: 2.25E-16

373519
type: SpeciesReference
stoichiometry: 1.0
species: 741039

373507
type: SpeciesReference
stoichiometry: 1.0
species: 742498

744538
type: Reaction
kinetic law: 373968
product: 373956
reactant: 373944
reactant: 373932
notes: Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers Note that this reaction also incorporates a translocation between compartments of different volumes.
fast: false
reversible: true

373968
type: KineticLaw
local parameters: 689492
local parameters: 689491
notes: kf*CaMKII_slash_CaMKII_minus_CaM*CaMKII_PSD_slash_NMDAR-kb*CaMKII_PSD_slash_CaMKII_minus_CaM_minus_PSD

689492
type: LocalParameter
units: 371312
value: 0.0

689491
type: LocalParameter
units: 371397
value: 1.08E-20

373956
type: SpeciesReference
stoichiometry: 1.0
species: 741979

373944
type: SpeciesReference
stoichiometry: 1.0
species: 742398

373932
type: SpeciesReference
stoichiometry: 1.0
species: 737599

749438
type: Reaction
kinetic law: 385842
product: 385830
product: 385818
reactant: 385806
fast: false
reversible: false

385842
type: KineticLaw
local parameters: 690061
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx

690061
type: LocalParameter
units: 371312
value: 3.5E-18

385830
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385818
type: SpeciesReference
stoichiometry: 1.0
species: 741799

385806
type: SpeciesReference
stoichiometry: 1.0
species: 740959

747678
type: Reaction
kinetic law: 381575
product: 381563
product: 381551
reactant: 381539
fast: false
reversible: false

381575
type: KineticLaw
local parameters: 689862
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx

689862
type: LocalParameter
units: 371312
value: 5.4E-16

381563
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381551
type: SpeciesReference
stoichiometry: 1.0
species: 741799

381539
type: SpeciesReference
stoichiometry: 1.0
species: 739739

745618
type: Reaction
kinetic law: 376591
product: 376578
reactant: 376566
reactant: 376554
fast: false
reversible: true

376591
type: KineticLaw
local parameters: 689631
local parameters: 689629
notes: k1*AMPAR_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx

689631
type: LocalParameter
units: 371312
value: 7.2E-16

689629
type: LocalParameter
units: 371397
value: 1.8106416E-16

376578
type: SpeciesReference
stoichiometry: 1.0
species: 738479

376566
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376554
type: SpeciesReference
stoichiometry: 1.0
species: 741299

747018
type: Reaction
kinetic law: 379981
product: 379969
reactant: 379957
reactant: 379945
fast: false
reversible: true

379981
type: KineticLaw
local parameters: 689788
local parameters: 689787
notes: k1*AMPAR_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx

689788
type: LocalParameter
units: 371312
value: 2.16E-15

689787
type: LocalParameter
units: 371397
value: 3.5998992E-16

379969
type: SpeciesReference
stoichiometry: 1.0
species: 739419

379957
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379945
type: SpeciesReference
stoichiometry: 1.0
species: 741219

747818
type: Reaction
kinetic law: 381915
product: 381903
reactant: 381890
reactant: 381878
fast: false
reversible: true

381915
type: KineticLaw
local parameters: 689878
local parameters: 689877
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx

689878
type: LocalParameter
units: 371312
value: 2.16E-15

689877
type: LocalParameter
units: 371397
value: 3.999888E-17

381903
type: SpeciesReference
stoichiometry: 1.0
species: 739819

381890
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381878
type: SpeciesReference
stoichiometry: 1.0
species: 741699

749838
type: Reaction
kinetic law: 386831
product: 386819
product: 386807
reactant: 386795
fast: false
reversible: false

386831
type: KineticLaw
local parameters: 690106
notes: k3*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

690106
type: LocalParameter
units: 371312
value: 2.0E-18

386819
type: SpeciesReference
stoichiometry: 1.0
species: 741859

386807
type: SpeciesReference
stoichiometry: 1.0
species: 741959

386795
type: SpeciesReference
stoichiometry: 1.0
species: 741899

742798
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

748378
type: Reaction
kinetic law: 383280
product: 383268
reactant: 383256
reactant: 383244
fast: false
reversible: true

383280
type: KineticLaw
local parameters: 689943
local parameters: 689941
notes: k1*AMPAR_memb_slash_A845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx

689943
type: LocalParameter
units: 371312
value: 6.8E-18

689941
type: LocalParameter
units: 371397
value: 8.7498E-18

383268
type: SpeciesReference
stoichiometry: 1.0
species: 740439

383256
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383244
type: SpeciesReference
stoichiometry: 1.0
species: 741619

744038
type: Reaction
kinetic law: 372880
product: 372868
reactant: 372856
reactant: 372844
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true

372880
type: KineticLaw
local parameters: 689417
local parameters: 689416
notes: kf*PP1_PSD_slash_I1_star_*PP1_PSD_slash_PP1_minus_active_PSD-kb*PP1_PSD_slash_PP1_minus_I1_star_

689417
type: LocalParameter
units: 371312
value: 1.0E-18

689416
type: LocalParameter
units: 371397
value: 4.9998E-15

372868
type: SpeciesReference
stoichiometry: 1.0
species: 740339

372856
type: SpeciesReference
stoichiometry: 1.0
species: 740379

372844
type: SpeciesReference
stoichiometry: 1.0
species: 740319

745638
type: Reaction
kinetic law: 376639
product: 376627
product: 376615
reactant: 376603
fast: false
reversible: false

376639
type: KineticLaw
local parameters: 689632
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx

689632
type: LocalParameter
units: 371312
value: 1.8E-16

376627
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376615
type: SpeciesReference
stoichiometry: 1.0
species: 741279

376603
type: SpeciesReference
stoichiometry: 1.0
species: 738479

743698
type: Reaction
kinetic law: 372060
product: 372047
product: 372035
reactant: 372023
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true

372060
type: KineticLaw
local parameters: 689363
local parameters: 689362
notes: kf*PP1_slash_PP1_minus_I1-kb*PP1_minus_active*PP1_slash_I1

689363
type: LocalParameter
units: 371397
value: 0.0

689362
type: LocalParameter
units: 371312
value: 9.0E-17

372047
type: SpeciesReference
stoichiometry: 1.0
species: 737979

372035
type: SpeciesReference
stoichiometry: 1.0
species: 737419

372023
type: SpeciesReference
stoichiometry: 1.0
species: 738039

746158
type: Reaction
kinetic law: 377896
product: 377884
product: 377872
reactant: 377860
fast: false
reversible: false

377896
type: KineticLaw
local parameters: 689691
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx

689691
type: LocalParameter
units: 371312
value: 1.8E-16

377884
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377872
type: SpeciesReference
stoichiometry: 1.0
species: 741639

377860
type: SpeciesReference
stoichiometry: 1.0
species: 738759

750218
type: Reaction
kinetic law: 387748
product: 387736
reactant: 387724
reactant: 387712
fast: false
reversible: true

387748
type: KineticLaw
local parameters: 690146
local parameters: 690144
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx

690146
type: LocalParameter
units: 371312
value: 2.0E-17

690144
type: LocalParameter
units: 371397
value: 2.77776E-19

387736
type: SpeciesReference
stoichiometry: 1.0
species: 742078

387724
type: SpeciesReference
stoichiometry: 1.0
species: 742978

387712
type: SpeciesReference
stoichiometry: 1.0
species: 741719

748298
type: Reaction
kinetic law: 383086
product: 383074
reactant: 383061
reactant: 383049
fast: false
reversible: true

383086
type: KineticLaw
local parameters: 689934
local parameters: 689932
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx

689934
type: LocalParameter
units: 371312
value: 6.8E-18

689932
type: LocalParameter
units: 371397
value: 8.7498E-18

383074
type: SpeciesReference
stoichiometry: 1.0
species: 740399

383061
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383049
type: SpeciesReference
stoichiometry: 1.0
species: 741719

745398
type: Reaction
kinetic law: 376051
product: 376039
product: 376027
reactant: 376015
fast: false
reversible: false

376051
type: KineticLaw
local parameters: 689605
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx

689605
type: LocalParameter
units: 371312
value: 1.8E-16

376039
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376027
type: SpeciesReference
stoichiometry: 1.0
species: 741419

376015
type: SpeciesReference
stoichiometry: 1.0
species: 738359

748318
type: Reaction
kinetic law: 383135
product: 383122
product: 383110
reactant: 383098
fast: false
reversible: false

383135
type: KineticLaw
local parameters: 689935
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx

689935
type: LocalParameter
units: 371312
value: 1.7E-18

383122
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383110
type: SpeciesReference
stoichiometry: 1.0
species: 741679

383098
type: SpeciesReference
stoichiometry: 1.0
species: 740399

744758
type: Reaction
kinetic law: 374502
product: 374490
product: 374478
reactant: 374466
fast: false
reversible: false

374502
type: KineticLaw
local parameters: 689518
notes: k3*PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

689518
type: LocalParameter
units: 371312
value: 2.25E-16

374490
type: SpeciesReference
stoichiometry: 1.0
species: 737419

374478
type: SpeciesReference
stoichiometry: 1.0
species: 737579

374466
type: SpeciesReference
stoichiometry: 1.0
species: 737519

750778
type: Reaction
kinetic law: 389109
product: 389096
reactant: 389083
reactant: 389070
fast: false
reversible: true

389109
type: KineticLaw
local parameters: 690202
local parameters: 690200
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx

690202
type: LocalParameter
units: 371312
value: 2.0E-17

690200
type: LocalParameter
units: 371397
value: 2.77776E-19

389096
type: SpeciesReference
stoichiometry: 1.0
species: 742358

389083
type: SpeciesReference
stoichiometry: 1.0
species: 742978

389070
type: SpeciesReference
stoichiometry: 1.0
species: 741639

747898
type: Reaction
kinetic law: 382110
product: 382098
reactant: 382086
reactant: 382074
fast: false
reversible: true

382110
type: KineticLaw
local parameters: 689887
local parameters: 689886
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx

689887
type: LocalParameter
units: 371312
value: 2.16E-15

689886
type: LocalParameter
units: 371397
value: 3.999888E-17

382098
type: SpeciesReference
stoichiometry: 1.0
species: 739859

382086
type: SpeciesReference
stoichiometry: 1.0
species: 739239

382074
type: SpeciesReference
stoichiometry: 1.0
species: 741579

748238
type: Reaction
kinetic law: 382939
product: 382927
product: 382915
reactant: 382903
fast: false
reversible: false

382939
type: KineticLaw
local parameters: 689926
notes: k3*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx

689926
type: LocalParameter
units: 371312
value: 1.5003E-16

382927
type: SpeciesReference
stoichiometry: 1.0
species: 740119

382915
type: SpeciesReference
stoichiometry: 1.0
species: 740019

382903
type: SpeciesReference
stoichiometry: 1.0
species: 740139

745338
type: Reaction
kinetic law: 375905
product: 375893
reactant: 375881
reactant: 375869
fast: false
reversible: true

375905
type: KineticLaw
local parameters: 689599
local parameters: 689598
notes: k1*AMPAR_slash_A831_star_845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx

689599
type: LocalParameter
units: 371312
value: 7.2E-16

689598
type: LocalParameter
units: 371397
value: 1.8106416E-16

375893
type: SpeciesReference
stoichiometry: 1.0
species: 738339

375881
type: SpeciesReference
stoichiometry: 1.0
species: 738199

375869
type: SpeciesReference
stoichiometry: 1.0
species: 741259

743938
type: Reaction
kinetic law: 372626
product: 372614
reactant: 372602
notes: Random rate.
fast: false
reversible: true

372626
type: KineticLaw
local parameters: 689399
local parameters: 689398
notes: kf*AC_slash_AC2_star_-kb*AC_slash_AC2

689399
type: LocalParameter
units: 371312
value: 0.0

689398
type: LocalParameter
units: 371312
value: 9.0E-18

372614
type: SpeciesReference
stoichiometry: 1.0
species: 739999

372602
type: SpeciesReference
stoichiometry: 1.0
species: 739979

744898
type: Reaction
kinetic law: 374842
product: 374830
reactant: 374818
reactant: 374806
fast: false
reversible: true

374842
type: KineticLaw
local parameters: 689534
local parameters: 689533
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx

689534
type: LocalParameter
units: 371312
value: 1.8E-16

689533
type: LocalParameter
units: 371397
value: 6.428808E-19

374830
type: SpeciesReference
stoichiometry: 1.0
species: 737739

374818
type: SpeciesReference
stoichiometry: 1.0
species: 742618

374806
type: SpeciesReference
stoichiometry: 1.0
species: 737599

742698
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

745058
type: Reaction
kinetic law: 375230
product: 375218
reactant: 375206
reactant: 375194
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true

375230
type: KineticLaw
local parameters: 689552
local parameters: 689551
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx

689552
type: LocalParameter
units: 371312
value: 7.50006E-16

689551
type: LocalParameter
units: 371397
value: 6.4584E-18

375218
type: SpeciesReference
stoichiometry: 1.0
species: 738139

375206
type: SpeciesReference
stoichiometry: 1.0
species: 738059

375194
type: SpeciesReference
stoichiometry: 1.0
species: 740339

746618
type: Reaction
kinetic law: 379011
product: 378999
reactant: 378987
reactant: 378974
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true

379011
type: KineticLaw
local parameters: 689743
local parameters: 689742
notes: k1*PP1_slash_I1_star_*PP2B_slash_CaNAB_minus_Ca4-k2*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx

689743
type: LocalParameter
units: 371312
value: 1.224E-17

689742
type: LocalParameter
units: 371397
value: 3.0779838E-18

378999
type: SpeciesReference
stoichiometry: 1.0
species: 739019

378987
type: SpeciesReference
stoichiometry: 1.0
species: 738999

378974
type: SpeciesReference
stoichiometry: 1.0
species: 737999

749598
type: Reaction
kinetic law: 386228
product: 386216
product: 386204
reactant: 386192
fast: false
reversible: false

386228
type: KineticLaw
local parameters: 690079
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx

690079
type: LocalParameter
units: 371312
value: 5.22E-17

386216
type: SpeciesReference
stoichiometry: 1.0
species: 741039

386204
type: SpeciesReference
stoichiometry: 1.0
species: 737819

386192
type: SpeciesReference
stoichiometry: 1.0
species: 741059

750718
type: Reaction
kinetic law: 388960
product: 388948
product: 388936
reactant: 388924
fast: false
reversible: false

388960
type: KineticLaw
local parameters: 690195
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx

690195
type: LocalParameter
units: 371312
value: 5.0E-18

388948
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388936
type: SpeciesReference
stoichiometry: 1.0
species: 741839

388924
type: SpeciesReference
stoichiometry: 1.0
species: 742318

747838
type: Reaction
kinetic law: 381965
product: 381952
product: 381940
reactant: 381927
fast: false
reversible: false

381965
type: KineticLaw
local parameters: 689880
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx

689880
type: LocalParameter
units: 371312
value: 5.4E-16

381952
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381940
type: SpeciesReference
stoichiometry: 1.0
species: 741819

381927
type: SpeciesReference
stoichiometry: 1.0
species: 739819

746918
type: Reaction
kinetic law: 379739
product: 379727
product: 379714
reactant: 379702
fast: false
reversible: false

379739
type: KineticLaw
local parameters: 689776
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx

689776
type: LocalParameter
units: 371312
value: 5.4E-16

379727
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379714
type: SpeciesReference
stoichiometry: 1.0
species: 741439

379702
type: SpeciesReference
stoichiometry: 1.0
species: 739359

747178
type: Reaction
kinetic law: 380367
product: 380355
reactant: 380343
reactant: 380330
fast: false
reversible: true

380367
type: KineticLaw
local parameters: 689806
local parameters: 689805
notes: k1*AMPAR_slash_A831_star__B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx

689806
type: LocalParameter
units: 371312
value: 2.16E-15

689805
type: LocalParameter
units: 371397
value: 3.5998992E-16

380355
type: SpeciesReference
stoichiometry: 1.0
species: 739499

380343
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380330
type: SpeciesReference
stoichiometry: 1.0
species: 741499

743498
type: Reaction
kinetic law: 371602
product: 371590
reactant: 371578
reactant: 371566
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true

371602
type: KineticLaw
local parameters: 689333
local parameters: 689332
notes: kf*CaM_slash_CaM*Ca^2-kb*CaM_minus_TR2_minus_Ca2

689333
type: LocalParameter
units: 371312
value: 6.48E-15

689332
type: LocalParameter
units: 371349
value: 6.47990604E-15

371590
type: SpeciesReference
stoichiometry: 1.0
species: 737959

371578
type: SpeciesReference
stoichiometry: 2.0
species: 737559

371566
type: SpeciesReference
stoichiometry: 1.0
species: 737779

746998
type: Reaction
kinetic law: 379933
product: 379921
product: 379908
reactant: 379896
fast: false
reversible: false

379933
type: KineticLaw
local parameters: 689785
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx

689785
type: LocalParameter
units: 371312
value: 5.4E-16

379921
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379908
type: SpeciesReference
stoichiometry: 1.0
species: 741279

379896
type: SpeciesReference
stoichiometry: 1.0
species: 739399

750438
type: Reaction
kinetic law: 388280
product: 388268
product: 388256
reactant: 388244
fast: false
reversible: false

388280
type: KineticLaw
local parameters: 690167
notes: k3*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx

690167
type: LocalParameter
units: 371312
value: 5.0E-18

388268
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388256
type: SpeciesReference
stoichiometry: 1.0
species: 741759

388244
type: SpeciesReference
stoichiometry: 1.0
species: 742178

742638
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 22.0
initial amount: NaN
in compartment: 737339

744198
type: Reaction
kinetic law: 373229
product: 373217
reactant: 373205
fast: false
reversible: true

373229
type: KineticLaw
local parameters: 689441
local parameters: 689440
notes: kf*AMPAR_slash_A845_star__B831_star_845_star_-kb*AMPAR_slash_AMPAR_deg

689441
type: LocalParameter
units: 371312
value: 0.0

689440
type: LocalParameter
units: 371312
value: 3.24E-21

373217
type: SpeciesReference
stoichiometry: 1.0
species: 742478

373205
type: SpeciesReference
stoichiometry: 1.0
species: 741339

746558
type: Reaction
kinetic law: 378865
product: 378853
product: 378841
reactant: 378829
fast: false
reversible: false

378865
type: KineticLaw
local parameters: 689736
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx

689736
type: LocalParameter
units: 371312
value: 1.8E-16

378853
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378841
type: SpeciesReference
stoichiometry: 1.0
species: 741599

378829
type: SpeciesReference
stoichiometry: 1.0
species: 738959

745583
type: Reaction
kinetic law: 376494
product: 376482
reactant: 376470
reactant: 376458
fast: false
reversible: true

376494
type: KineticLaw
local parameters: 689626
local parameters: 689625
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx

689626
type: LocalParameter
units: 371312
value: 7.2E-16

689625
type: LocalParameter
units: 371397
value: 1.8106416E-16

376482
type: SpeciesReference
stoichiometry: 1.0
species: 738459

376470
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376458
type: SpeciesReference
stoichiometry: 1.0
species: 741399

750578
type: Reaction
kinetic law: 388619
product: 388607
reactant: 388595
reactant: 388583
fast: false
reversible: true

388619
type: KineticLaw
local parameters: 690182
local parameters: 690180
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx

690182
type: LocalParameter
units: 371312
value: 2.0E-17

690180
type: LocalParameter
units: 371397
value: 2.77776E-19

388607
type: SpeciesReference
stoichiometry: 1.0
species: 742258

388595
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388583
type: SpeciesReference
stoichiometry: 1.0
species: 741759

742718
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

743818
type: Reaction
kinetic law: 372349
product: 372337
reactant: 372325
reactant: 372313
fast: false
reversible: true

372349
type: KineticLaw
local parameters: 689381
local parameters: 689380
notes: kf*PKA_slash_R2C2_minus_cAMP2*cAMP-kb*PKA_slash_R2C2_minus_cAMP3

689381
type: LocalParameter
units: 371312
value: 9.9E-15

689380
type: LocalParameter
units: 371397
value: 6.750054E-15

372337
type: SpeciesReference
stoichiometry: 1.0
species: 739119

372325
type: SpeciesReference
stoichiometry: 1.0
species: 737539

372313
type: SpeciesReference
stoichiometry: 1.0
species: 739099

749298
type: Reaction
kinetic law: 385503
product: 385491
reactant: 385479
reactant: 385467
fast: false
reversible: true

385503
type: KineticLaw
local parameters: 690046
local parameters: 690045
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx

690046
type: LocalParameter
units: 371312
value: 1.4E-17

690045
type: LocalParameter
units: 371397
value: 8.7498E-18

385491
type: SpeciesReference
stoichiometry: 1.0
species: 740899

385479
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385467
type: SpeciesReference
stoichiometry: 1.0
species: 741779

746358
type: Reaction
kinetic law: 378381
product: 378369
product: 378357
reactant: 378345
fast: false
reversible: false

378381
type: KineticLaw
local parameters: 689713
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx

689713
type: LocalParameter
units: 371312
value: 1.8E-16

378369
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378357
type: SpeciesReference
stoichiometry: 1.0
species: 741579

378345
type: SpeciesReference
stoichiometry: 1.0
species: 738859

748718
type: Reaction
kinetic law: 384104
product: 384092
product: 384080
reactant: 384068
fast: false
reversible: false

384104
type: KineticLaw
local parameters: 689980
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx

689980
type: LocalParameter
units: 371312
value: 3.5E-18

384092
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384080
type: SpeciesReference
stoichiometry: 1.0
species: 741619

384068
type: SpeciesReference
stoichiometry: 1.0
species: 740599

745838
type: Reaction
kinetic law: 377121
product: 377109
product: 377097
reactant: 377085
fast: false
reversible: false

377121
type: KineticLaw
local parameters: 689655
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx

689655
type: LocalParameter
units: 371312
value: 1.8E-16

377109
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377097
type: SpeciesReference
stoichiometry: 1.0
species: 741259

377085
type: SpeciesReference
stoichiometry: 1.0
species: 738579

750498
type: Reaction
kinetic law: 388425
product: 388412
reactant: 388400
reactant: 388388
fast: false
reversible: true

388425
type: KineticLaw
local parameters: 690174
local parameters: 690172
notes: k1*AMPAR_memb_slash_A_B*CaMKII_PSD_slash_actCaMKII_minus_PSD-k2*CaMKII_PSD_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx

690174
type: LocalParameter
units: 371312
value: 2.0E-17

690172
type: LocalParameter
units: 371397
value: 2.77776E-19

388412
type: SpeciesReference
stoichiometry: 1.0
species: 742218

388400
type: SpeciesReference
stoichiometry: 1.0
species: 742978

388388
type: SpeciesReference
stoichiometry: 1.0
species: 741539

746698
type: Reaction
kinetic law: 379204
product: 379192
reactant: 379180
reactant: 379168
notes: Same rates as PKA-phosph-I1
fast: false
reversible: true

379204
type: KineticLaw
local parameters: 689752
local parameters: 689751
notes: k1*AC_slash_cAMP_minus_PDE*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx

689752
type: LocalParameter
units: 371312
value: 3.24E-15

689751
type: LocalParameter
units: 371397
value: 5.399946E-16

379192
type: SpeciesReference
stoichiometry: 1.0
species: 739259

379180
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379168
type: SpeciesReference
stoichiometry: 1.0
species: 740039

746038
type: Reaction
kinetic law: 377606
product: 377594
product: 377582
reactant: 377569
fast: false
reversible: false

377606
type: KineticLaw
local parameters: 689677
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx

689677
type: LocalParameter
units: 371312
value: 1.8E-16

377594
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377582
type: SpeciesReference
stoichiometry: 1.0
species: 741539

377569
type: SpeciesReference
stoichiometry: 1.0
species: 738699

750138
type: Reaction
kinetic law: 387556
product: 387544
reactant: 387532
reactant: 387520
fast: false
reversible: true

387556
type: KineticLaw
local parameters: 690138
local parameters: 690136
notes: k1*CaMKII_PSD_slash_CaMKII_minus_CaM_minus_PSD*CaMKII_PSD_slash_tot_minus_auto_minus_PSD-k2*CaMKII_PSD_slash_tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx

690138
type: LocalParameter
units: 371312
value: 2.0E-17

690136
type: LocalParameter
units: 371397
value: 4.99998E-20

387544
type: SpeciesReference
stoichiometry: 1.0
species: 742039

387532
type: SpeciesReference
stoichiometry: 1.0
species: 742938

387520
type: SpeciesReference
stoichiometry: 1.0
species: 741979

748858
type: Reaction
kinetic law: 384441
product: 384429
reactant: 384417
reactant: 384405
fast: false
reversible: true

384441
type: KineticLaw
local parameters: 689997
local parameters: 689995
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx

689997
type: LocalParameter
units: 371312
value: 6.8E-18

689995
type: LocalParameter
units: 371397
value: 8.7498E-18

384429
type: SpeciesReference
stoichiometry: 1.0
species: 740679

384417
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384405
type: SpeciesReference
stoichiometry: 1.0
species: 741759

747938
type: Reaction
kinetic law: 382206
product: 382194
reactant: 382182
reactant: 382170
fast: false
reversible: true

382206
type: KineticLaw
local parameters: 689892
local parameters: 689890
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx

689892
type: LocalParameter
units: 371312
value: 2.16E-15

689890
type: LocalParameter
units: 371397
value: 3.999888E-17

382194
type: SpeciesReference
stoichiometry: 1.0
species: 739879

382182
type: SpeciesReference
stoichiometry: 1.0
species: 739239

382170
type: SpeciesReference
stoichiometry: 1.0
species: 741779

749158
type: Reaction
kinetic law: 385167
product: 385155
product: 385143
reactant: 385131
fast: false
reversible: false

385167
type: KineticLaw
local parameters: 690030
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx

690030
type: LocalParameter
units: 371312
value: 3.5E-18

385155
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385143
type: SpeciesReference
stoichiometry: 1.0
species: 741719

385131
type: SpeciesReference
stoichiometry: 1.0
species: 740819

746218
type: Reaction
kinetic law: 378043
product: 378030
reactant: 378018
reactant: 378005
fast: false
reversible: true

378043
type: KineticLaw
local parameters: 689698
local parameters: 689697
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx

689698
type: LocalParameter
units: 371312
value: 7.2E-16

689697
type: LocalParameter
units: 371397
value: 2.011824E-17

378030
type: SpeciesReference
stoichiometry: 1.0
species: 738799

378018
type: SpeciesReference
stoichiometry: 1.0
species: 738199

378005
type: SpeciesReference
stoichiometry: 1.0
species: 741639

747398
type: Reaction
kinetic law: 380900
product: 380888
product: 380875
reactant: 380863
fast: false
reversible: false

380900
type: KineticLaw
local parameters: 689830
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx

689830
type: LocalParameter
units: 371312
value: 5.4E-16

380888
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380875
type: SpeciesReference
stoichiometry: 1.0
species: 741339

380863
type: SpeciesReference
stoichiometry: 1.0
species: 739599

750158
type: Reaction
kinetic law: 387604
product: 387592
product: 387580
reactant: 387568
fast: false
reversible: false

387604
type: KineticLaw
local parameters: 690139
notes: k3*CaMKII_PSD_slash_tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx

690139
type: LocalParameter
units: 371312
value: 5.0E-18

387592
type: SpeciesReference
stoichiometry: 1.0
species: 742938

387580
type: SpeciesReference
stoichiometry: 1.0
species: 741998

387568
type: SpeciesReference
stoichiometry: 1.0
species: 742039

747578
type: Reaction
kinetic law: 381334
product: 381322
reactant: 381310
reactant: 381298
fast: false
reversible: true

381334
type: KineticLaw
local parameters: 689851
local parameters: 689850
notes: k1*AMPAR_memb_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx

689851
type: LocalParameter
units: 371312
value: 2.16E-15

689850
type: LocalParameter
units: 371397
value: 3.999888E-17

381322
type: SpeciesReference
stoichiometry: 1.0
species: 739699

381310
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381298
type: SpeciesReference
stoichiometry: 1.0
species: 741539

749898
type: Reaction
kinetic law: 386977
product: 386965
reactant: 386953
reactant: 386941
fast: false
reversible: true

386977
type: KineticLaw
local parameters: 690114
local parameters: 690112
notes: k1*CaMKII_PSD_slash_CaMKII_star__star__star__minus_PSD*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD-k2*PP1_CaMKII_PSD_slash_PP1_minus_active_CaMKII_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

690114
type: LocalParameter
units: 371312
value: 8.0E-18

690112
type: LocalParameter
units: 371397
value: 4.99998E-18

386965
type: SpeciesReference
stoichiometry: 1.0
species: 741919

386953
type: SpeciesReference
stoichiometry: 1.0
species: 741859

386941
type: SpeciesReference
stoichiometry: 1.0
species: 741958

742658
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

747338
type: Reaction
kinetic law: 380754
product: 380742
reactant: 380730
reactant: 380718
fast: false
reversible: true

380754
type: KineticLaw
local parameters: 689824
local parameters: 689823
notes: k1*AMPAR_slash_A831_star_845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx

689824
type: LocalParameter
units: 371312
value: 2.16E-15

689823
type: LocalParameter
units: 371397
value: 3.5998992E-16

380742
type: SpeciesReference
stoichiometry: 1.0
species: 739579

380730
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380718
type: SpeciesReference
stoichiometry: 1.0
species: 741259

744578
type: Reaction
kinetic law: 374064
product: 374052
reactant: 374040
reactant: 374028
fast: false
reversible: true

374064
type: KineticLaw
local parameters: 689498
local parameters: 689497
notes: k1*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

689498
type: LocalParameter
units: 371312
value: 9.0E-16

689497
type: LocalParameter
units: 371397
value: 2.2062942E-16

374052
type: SpeciesReference
stoichiometry: 1.0
species: 737439

374040
type: SpeciesReference
stoichiometry: 1.0
species: 737419

374028
type: SpeciesReference
stoichiometry: 1.0
species: 737619

749478
type: Reaction
kinetic law: 385939
product: 385927
product: 385915
reactant: 385903
fast: false
reversible: false

385939
type: KineticLaw
local parameters: 690066
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx

690066
type: LocalParameter
units: 371312
value: 3.5E-18

385927
type: SpeciesReference
stoichiometry: 1.0
species: 740379

385915
type: SpeciesReference
stoichiometry: 1.0
species: 741739

385903
type: SpeciesReference
stoichiometry: 1.0
species: 740979

747058
type: Reaction
kinetic law: 380077
product: 380065
reactant: 380053
reactant: 380041
fast: false
reversible: true

380077
type: KineticLaw
local parameters: 689793
local parameters: 689791
notes: k1*AMPAR_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx

689793
type: LocalParameter
units: 371312
value: 2.16E-15

689791
type: LocalParameter
units: 371397
value: 3.5998992E-16

380065
type: SpeciesReference
stoichiometry: 1.0
species: 739439

380053
type: SpeciesReference
stoichiometry: 1.0
species: 739239

380041
type: SpeciesReference
stoichiometry: 1.0
species: 741419

746878
type: Reaction
kinetic law: 379639
product: 379627
product: 379614
reactant: 379602
fast: false
reversible: false

379639
type: KineticLaw
local parameters: 689772
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx

689772
type: LocalParameter
units: 371312
value: 5.4E-16

379627
type: SpeciesReference
stoichiometry: 1.0
species: 739239

379614
type: SpeciesReference
stoichiometry: 1.0
species: 741259

379602
type: SpeciesReference
stoichiometry: 1.0
species: 739339

747518
type: Reaction
kinetic law: 381190
product: 381178
product: 381166
reactant: 381154
fast: false
reversible: false

381190
type: KineticLaw
local parameters: 689844
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx

689844
type: LocalParameter
units: 371312
value: 5.4E-16

381178
type: SpeciesReference
stoichiometry: 1.0
species: 739239

381166
type: SpeciesReference
stoichiometry: 1.0
species: 741719

381154
type: SpeciesReference
stoichiometry: 1.0
species: 739659

744318
type: Reaction
kinetic law: 373495
product: 373483
reactant: 373471
reactant: 373459
notes: Exo rates are scaled from earlier model versions to account for binding of anchor. We have about 200 molecules of anchor in the whole model. Here we select rates to give us a max of about 150 molecules of GluR at the synapse.
fast: false
reversible: true

373495
type: KineticLaw
local parameters: 689459
local parameters: 689458
notes: kf*AMPAR_slash_A845_star__B845_star_*Anchor-kb*AMPAR_memb_slash_A845_star__B845_star_

689459
type: LocalParameter
units: 371312
value: 8.0E-20

689458
type: LocalParameter
units: 371397
value: 1.08E-19

373483
type: SpeciesReference
stoichiometry: 1.0
species: 741719

373471
type: SpeciesReference
stoichiometry: 1.0
species: 741519

373459
type: SpeciesReference
stoichiometry: 1.0
species: 741299

749618
type: Reaction
kinetic law: 386276
product: 386264
reactant: 386252
reactant: 386240
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

386276
type: KineticLaw
local parameters: 690082
local parameters: 690081
notes: k1*CaM_slash_neurogranin_minus_CaM*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx

690082
type: LocalParameter
units: 371312
value: 1.26E-16

690081
type: LocalParameter
units: 371397
value: 5.507838E-18

386264
type: SpeciesReference
stoichiometry: 1.0
species: 741079

386252
type: SpeciesReference
stoichiometry: 1.0
species: 741039

386240
type: SpeciesReference
stoichiometry: 1.0
species: 737799

742898
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737339

744078
type: Reaction
kinetic law: 372964
product: 372952
reactant: 372940
fast: false
reversible: true

372964
type: KineticLaw
local parameters: 689423
local parameters: 689422
notes: kf*AMPAR_slash_GluR23_M-kb*AMPAR_slash_GluR23_I

689423
type: LocalParameter
units: 371312
value: 1.26E-19

689422
type: LocalParameter
units: 371312
value: 3.5E-21

372952
type: SpeciesReference
stoichiometry: 1.0
species: 741179

372940
type: SpeciesReference
stoichiometry: 1.0
species: 741159

746198
type: Reaction
kinetic law: 377993
product: 377981
product: 377969
reactant: 377957
fast: false
reversible: false

377993
type: KineticLaw
local parameters: 689695
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx

689695
type: LocalParameter
units: 371312
value: 1.8E-16

377981
type: SpeciesReference
stoichiometry: 1.0
species: 738199

377969
type: SpeciesReference
stoichiometry: 1.0
species: 741559

377957
type: SpeciesReference
stoichiometry: 1.0
species: 738779

748558
type: Reaction
kinetic law: 383717
product: 383705
product: 383693
reactant: 383681
fast: false
reversible: false

383717
type: KineticLaw
local parameters: 689962
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx

689962
type: LocalParameter
units: 371312
value: 1.7E-18

383705
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383693
type: SpeciesReference
stoichiometry: 1.0
species: 741559

383681
type: SpeciesReference
stoichiometry: 1.0
species: 740519

748358
type: Reaction
kinetic law: 383232
product: 383220
product: 383208
reactant: 383196
fast: false
reversible: false

383232
type: KineticLaw
local parameters: 689940
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx

689940
type: LocalParameter
units: 371312
value: 1.7E-18

383220
type: SpeciesReference
stoichiometry: 1.0
species: 740379

383208
type: SpeciesReference
stoichiometry: 1.0
species: 741619

383196
type: SpeciesReference
stoichiometry: 1.0
species: 740419

748138
type: Reaction
kinetic law: 382699
product: 382687
reactant: 382675
reactant: 382663
notes: Best rates are from Conti et al Biochem 34 7979-7987 1995. Though these are for the Sertoli cell form, it looks like they carry nicely into alternatively spliced brain form. See Sette et al JBC 269:28 18271-18274 Km ~2 uM, Vmax est ~ 10 umol/min/mg for pure form. Brain protein is 93 kD but this was 67. So k3 ~10, k2 ~40, k1 ~4.2e-6
fast: false
reversible: true

382699
type: KineticLaw
local parameters: 689916
local parameters: 689914
notes: k1*cAMP*AC_slash_cAMP_minus_PDE-k2*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx

689916
type: LocalParameter
units: 371312
value: 3.6E-15

689914
type: LocalParameter
units: 371397
value: 2.2680162E-16

382687
type: SpeciesReference
stoichiometry: 1.0
species: 740059

382675
type: SpeciesReference
stoichiometry: 1.0
species: 740039

382663
type: SpeciesReference
stoichiometry: 1.0
species: 737539

742738
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 737359

744018
type: Reaction
kinetic law: 372832
product: 372820
product: 372808
reactant: 372796
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true

372832
type: KineticLaw
local parameters: 689414
local parameters: 689413
notes: kf*PP1_PSD_slash_PP1_minus_I1-kb*PP1_PSD_slash_I1*PP1_PSD_slash_PP1_minus_active_PSD

689414
type: LocalParameter
units: 371397
value: 0.0

689413
type: LocalParameter
units: 371312
value: 1.0E-17

372820
type: SpeciesReference
stoichiometry: 1.0
species: 740379

372808
type: SpeciesReference
stoichiometry: 1.0
species: 740299

372796
type: SpeciesReference
stoichiometry: 1.0
species: 740359

744718
type: Reaction
kinetic law: 374404
product: 374391
product: 374379
reactant: 374367
fast: false
reversible: false

374404
type: KineticLaw
local parameters: 689513
notes: k3*PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

689513
type: LocalParameter
units: 371312
value: 2.25E-16

374391
type: SpeciesReference
stoichiometry: 1.0
species: 737419

374379
type: SpeciesReference
stoichiometry: 1.0
species: 737759

374367
type: SpeciesReference
stoichiometry: 1.0
species: 737499

744798
type: Reaction
kinetic law: 374600
product: 374588
product: 374576
reactant: 374563
fast: false
reversible: false

374600
type: KineticLaw
local parameters: 689522
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx

689522
type: LocalParameter
units: 371312
value: 5.4E-16

374588
type: SpeciesReference
stoichiometry: 1.0
species: 742598

374576
type: SpeciesReference
stoichiometry: 1.0
species: 737639

374563
type: SpeciesReference
stoichiometry: 1.0
species: 737679

748698
type: Reaction
kinetic law: 384056
product: 384044
reactant: 384032
reactant: 384019
fast: false
reversible: true

384056
type: KineticLaw
local parameters: 689979
local parameters: 689977
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx

689979
type: LocalParameter
units: 371312
value: 1.4E-17

689977
type: LocalParameter
units: 371397
value: 8.7498E-18

384044
type: SpeciesReference
stoichiometry: 1.0
species: 740599

384032
type: SpeciesReference
stoichiometry: 1.0
species: 740379

384019
type: SpeciesReference
stoichiometry: 1.0
species: 741639

745538
type: Reaction
kinetic law: 376396
product: 376384
reactant: 376371
reactant: 376358
fast: false
reversible: true

376396
type: KineticLaw
local parameters: 689622
local parameters: 689620
notes: k1*AMPAR_slash_A_B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx

689622
type: LocalParameter
units: 371312
value: 7.2E-16

689620
type: LocalParameter
units: 371397
value: 1.8106416E-16

376384
type: SpeciesReference
stoichiometry: 1.0
species: 738439

376371
type: SpeciesReference
stoichiometry: 1.0
species: 738199

376358
type: SpeciesReference
stoichiometry: 1.0
species: 741379