MODEL9087255381
type: SBMLModel
reaction: 770516
reaction: 773176
reaction: 775675
species: 767156
reaction: 776215
reaction: 772916
species: 768076
reaction: 773836
reaction: 770676
rule: 769596
reaction: 774355
reaction: 773856
reaction: 776435
species: 764776
reaction: 770696
species: 767176
reaction: 771456
reaction: 770796
reaction: 775515
species: 766496
species: 764536
species: 766196
species: 768436
species: 766156
reaction: 773116
species: 765016
species: 764296
reaction: 771176
species: 768636
reaction: 771476
reaction: 771016
species: 765836
reaction: 773496
reaction: 771696
reaction: 775635
reaction: 773756
is described by: http://identifiers.org/pubmed/16110334
reaction: 771776
reaction: 776955
species: 764216
compartment: 763777
reaction: 775155
species: 767016
reaction: 773296
reaction: 772696
reaction: 775175
reaction: 775435
reaction: 774935
species: 768596
species: 765176
species: 765356
reaction: 774436
reaction: 773776
species: 767776
reaction: 773316
species: 767496
reaction: 771376
species: 768396
species: 767296
reaction: 774236
reaction: 776595
species: 766016
reaction: 774276
species: 765116
reaction: 771856
species: 765896
species: 766916
species: 769316
species: 766216
species: 766996
reaction: 770236
species: 766736
reaction: 770436
species: 764016
rule: 769656
species: 768096
species: 768056
species: 766936
reaction: 774576

770516
type: Reaction
kinetic law: 346568
product: 346556
reactant: 346544
reactant: 346532
notes: Same as for transloc_1
fast: false
reversible: true

346568
type: KineticLaw
local parameters: 830133
local parameters: 830130
notes: kf*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*NMDAR-kb*CaMKII_minus_thr286_minus_CaM_minus_PSD

830133
type: LocalParameter
units: 344978
value: 0.0

345002
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

344990
type: SBMLUnit
exponent: 1.0
scale: 0
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kind: LITRE

830130
type: LocalParameter
units: 345062
value: 1.08E-20

345099
type: SBMLUnit
exponent: -1.0
scale: 0
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kind: SECOND

345087
type: SBMLUnit
exponent: -1.0
scale: -6
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kind: MOLE

345074
type: SBMLUnit
exponent: 2.0
scale: 0
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kind: LITRE

346556
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species: 765736

765736
type: Species
constant: false
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has only substance units: false
initial concentration: 0.0
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763776
type: Compartment
constant: true
size: 1.0E-17
spatial dimensions: 3.0

346544
type: SpeciesReference
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species: 767616

767616
type: Species
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has only substance units: false
initial concentration: 120.0
initial amount: NaN
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346532
type: SpeciesReference
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species: 764636

764636
type: Species
constant: false
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763757
type: Compartment
constant: true
size: 9.0E-17
spatial dimensions: 3.0

773176
type: Reaction
kinetic law: 352890
product: 352878
reactant: 352866
reactant: 352854
notes: Rate is 1/6 of the CaM stim form. We\'ll just reduce all lf k1, k2, k3 so that the Vmax goes down 1/6.
fast: false
reversible: true

352890
type: KineticLaw
local parameters: 830775
local parameters: 830772
notes: k1*cAMP*AC_slash_PDE1-k2*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx

830775
type: LocalParameter
units: 344978
value: 6.003E-16

830772
type: LocalParameter
units: 345062
value: 1.8900054E-17

352878
type: SpeciesReference
stoichiometry: 1.0
species: 765656

765656
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
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352866
type: SpeciesReference
stoichiometry: 1.0
species: 765636

765636
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.59259259259259
initial amount: NaN
in compartment: 763757

352854
type: SpeciesReference
stoichiometry: 1.0
species: 763916

763916
type: Species
constant: false
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has only substance units: false
initial concentration: 0.0
initial amount: NaN
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775675
type: Reaction
kinetic law: 359635
product: 359623
product: 359611
reactant: 359599
fast: false
reversible: false

359635
type: KineticLaw
local parameters: 831397
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx

831397
type: LocalParameter
units: 344978
value: 1.8E-16

359623
type: SpeciesReference
stoichiometry: 1.0
species: 767636

767636
type: Species
constant: false
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has only substance units: false
initial concentration: 0.0
initial amount: NaN
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359611
type: SpeciesReference
stoichiometry: 1.0
species: 767316

767316
type: Species
constant: false
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has only substance units: false
initial concentration: 0.0
initial amount: NaN
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359599
type: SpeciesReference
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species: 767776

767776
type: Species
constant: false
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has only substance units: false
initial concentration: 0.0
initial amount: NaN
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767156
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00538592592592593
initial amount: NaN
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776215
type: Reaction
kinetic law: 360941
product: 360929
reactant: 360917
reactant: 360905
fast: false
reversible: true

360941
type: KineticLaw
local parameters: 831520
local parameters: 831517
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx

831520
type: LocalParameter
units: 344978
value: 7.2E-16

831517
type: LocalParameter
units: 345062
value: 1.8106416E-16

360929
type: SpeciesReference
stoichiometry: 1.0
species: 768056

768056
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
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360917
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360905
type: SpeciesReference
stoichiometry: 1.0
species: 767456

767456
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

772916
type: Reaction
kinetic law: 352257
product: 352245
product: 352233
reactant: 352220
fast: false
reversible: false

352257
type: KineticLaw
local parameters: 830712
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx

830712
type: LocalParameter
units: 344978
value: 1.8E-16

352245
type: SpeciesReference
stoichiometry: 1.0
species: 765076

765076
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.111111111111111
initial amount: NaN
in compartment: 763757

352233
type: SpeciesReference
stoichiometry: 1.0
species: 766296

766296
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 8.0
initial amount: NaN
in compartment: 763776

352220
type: SpeciesReference
stoichiometry: 1.0
species: 765136

765136
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.21555555555556E-7
initial amount: NaN
in compartment: 763757

768076
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

773836
type: Reaction
kinetic law: 354479
product: 354467
product: 354455
reactant: 354442
fast: false
reversible: false

354479
type: KineticLaw
local parameters: 830922
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx

830922
type: LocalParameter
units: 344978
value: 5.0E-18

354467
type: SpeciesReference
stoichiometry: 1.0
species: 769136

769136
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763776

354455
type: SpeciesReference
stoichiometry: 1.0
species: 768576

768576
type: Species
constant: false
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has only substance units: false
initial concentration: 0.0
initial amount: NaN
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354442
type: SpeciesReference
stoichiometry: 1.0
species: 766196

766196
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 763776

770676
type: Reaction
kinetic law: 346931
product: 346919
reactant: 346907
reactant: 346895
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true

346931
type: KineticLaw
local parameters: 830181
local parameters: 830178
notes: kf*CaM_minus_Ca3*Ca-kb*CaM_minus_Ca4

830181
type: LocalParameter
units: 344978
value: 9.0E-16

830178
type: LocalParameter
units: 345062
value: 4.1849946E-17

346919
type: SpeciesReference
stoichiometry: 1.0
species: 763796

763796
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

346907
type: SpeciesReference
stoichiometry: 1.0
species: 763936

763936
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 763757

346895
type: SpeciesReference
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species: 764956

764956
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

774355
type: Reaction
kinetic law: 355838
product: 355826
product: 355814
reactant: 355802
fast: false
reversible: false

355838
type: KineticLaw
local parameters: 831046
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx

831046
type: LocalParameter
units: 344978
value: 1.7E-18

355826
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species: 766376

766376
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 8.0
initial amount: NaN
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355814
type: SpeciesReference
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species: 768616

768616
type: Species
constant: false
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initial concentration: 0.0
initial amount: NaN
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355802
type: SpeciesReference
stoichiometry: 1.0
species: 766576

766576
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

773856
type: Reaction
kinetic law: 354527
product: 354515
reactant: 354503
reactant: 354491
fast: false
reversible: true

354527
type: KineticLaw
local parameters: 830928
local parameters: 830925
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx

830928
type: LocalParameter
units: 344978
value: 2.0E-17

830925
type: LocalParameter
units: 345062
value: 2.77776E-19

354515
type: SpeciesReference
stoichiometry: 1.0
species: 766216

766216
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 763776

354503
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354491
type: SpeciesReference
stoichiometry: 1.0
species: 768776

768776
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

776435
type: Reaction
kinetic law: 361472
product: 361460
product: 361448
reactant: 361436
fast: false
reversible: false

361472
type: KineticLaw
local parameters: 831568
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx

831568
type: LocalParameter
units: 344978
value: 1.8E-16

361460
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361448
type: SpeciesReference
stoichiometry: 1.0
species: 768716

768716
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

361436
type: SpeciesReference
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species: 768156

768156
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

764776
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

770696
type: Reaction
kinetic law: 346967
product: 346955
reactant: 346943
fast: false
reversible: true

346967
type: KineticLaw
local parameters: 830187
local parameters: 830184
notes: kf*AMPAR_slash_GluR23_M-kb*AMPAR_slash_GluR23_I

830187
type: LocalParameter
units: 344978
value: 1.26E-19

830184
type: LocalParameter
units: 344978
value: 3.5E-21

346955
type: SpeciesReference
stoichiometry: 1.0
species: 767276

767276
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0925925925925926
initial amount: NaN
in compartment: 763757

346943
type: SpeciesReference
stoichiometry: 1.0
species: 767256

767256
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.5
initial amount: NaN
in compartment: 763776

767176
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

771456
type: Reaction
kinetic law: 348706
product: 348694
reactant: 348682
reactant: 348670
fast: false
reversible: true

348706
type: KineticLaw
local parameters: 830385
local parameters: 830382
notes: k1*AMPAR_slash_A_B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx

830385
type: LocalParameter
units: 344978
value: 2.16E-15

830382
type: LocalParameter
units: 345062
value: 3.5998992E-16

348694
type: SpeciesReference
stoichiometry: 1.0
species: 764037

764037
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

348682
type: SpeciesReference
stoichiometry: 1.0
species: 763956

763956
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

348670
type: SpeciesReference
stoichiometry: 1.0
species: 767516

767516
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

770796
type: Reaction
kinetic law: 347195
product: 347183
reactant: 347171
fast: false
reversible: true

347195
type: KineticLaw
local parameters: 830217
local parameters: 830214
notes: kf*AMPAR_slash_A835_star_845_star__B835_star_845_star_-kb*AMPAR_slash_AMPAR_deg

830217
type: LocalParameter
units: 344978
value: 0.0

830214
type: LocalParameter
units: 344978
value: 3.24E-21

347183
type: SpeciesReference
stoichiometry: 1.0
species: 768896

768896
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

347171
type: SpeciesReference
stoichiometry: 1.0
species: 767456

775515
type: Reaction
kinetic law: 359247
product: 359235
product: 359223
reactant: 359211
fast: false
reversible: false

359247
type: KineticLaw
local parameters: 831361
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx

831361
type: LocalParameter
units: 344978
value: 3.06E-17

359235
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359223
type: SpeciesReference
stoichiometry: 1.0
species: 765056

765056
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

359211
type: SpeciesReference
stoichiometry: 1.0
species: 767696

767696
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

766496
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

764536
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

768436
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 27.3333333333333
initial amount: NaN
in compartment: 763776

766156
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 763776

773116
type: Reaction
kinetic law: 352744
product: 352731
product: 352719
reactant: 352706
fast: false
reversible: false

352744
type: KineticLaw
local parameters: 830760
notes: k3*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx

830760
type: LocalParameter
units: 344978
value: 9.0E-16

352731
type: SpeciesReference
stoichiometry: 1.0
species: 765556

765556
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.555555555555556
initial amount: NaN
in compartment: 763757

352719
type: SpeciesReference
stoichiometry: 1.0
species: 765536

765536
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

352706
type: SpeciesReference
stoichiometry: 1.0
species: 765576

765576
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

765016
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

764296
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

771176
type: Reaction
kinetic law: 348027
product: 348015
reactant: 348003
reactant: 347991
fast: false
reversible: true

348027
type: KineticLaw
local parameters: 830322
local parameters: 830319
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

830322
type: LocalParameter
units: 344978
value: 9.0E-16

830319
type: LocalParameter
units: 345062
value: 2.2062942E-16

348015
type: SpeciesReference
stoichiometry: 1.0
species: 763876

763876
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

348003
type: SpeciesReference
stoichiometry: 1.0
species: 763797

763797
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 763757

347991
type: SpeciesReference
stoichiometry: 1.0
species: 764656

764656
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

768636
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

771476
type: Reaction
kinetic law: 348754
product: 348742
product: 348730
reactant: 348718
fast: false
reversible: false

348754
type: KineticLaw
local parameters: 830388
notes: k3*PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx

830388
type: LocalParameter
units: 344978
value: 5.4E-16

348742
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348730
type: SpeciesReference
stoichiometry: 1.0
species: 767536

767536
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

348718
type: SpeciesReference
stoichiometry: 1.0
species: 764037

771016
type: Reaction
kinetic law: 347652
product: 347640
reactant: 347627
fast: false
reversible: true

347652
type: KineticLaw
local parameters: 830283
local parameters: 830280
notes: kf*basal_CaMKII_PSD_control-kb*basal_CaMKII_PSD

830283
type: LocalParameter
units: 344978
value: 1.0E-17

830280
type: LocalParameter
units: 344978
value: 1.0E-17

347640
type: SpeciesReference
stoichiometry: 1.0
species: 768416

768416
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763776

347627
type: SpeciesReference
stoichiometry: 1.0
species: 768996

768996
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763776

765836
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

773496
type: Reaction
kinetic law: 353662
product: 353650
reactant: 353638
reactant: 353626
fast: false
reversible: true

353662
type: KineticLaw
local parameters: 830847
local parameters: 830844
notes: k1*AMPAR_memb_slash_A_B*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx

830847
type: LocalParameter
units: 344978
value: 2.0E-17

830844
type: LocalParameter
units: 345062
value: 2.77776E-19

353650
type: SpeciesReference
stoichiometry: 1.0
species: 766036

766036
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 763776

353638
type: SpeciesReference
stoichiometry: 1.0
species: 769136

353626
type: SpeciesReference
stoichiometry: 1.0
species: 768516

768516
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

771696
type: Reaction
kinetic law: 349286
product: 349274
reactant: 349262
reactant: 349250
fast: false
reversible: true

349286
type: KineticLaw
local parameters: 830439
local parameters: 830436
notes: k1*AMPAR_slash_A_B845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx

830439
type: LocalParameter
units: 344978
value: 2.16E-15

830436
type: LocalParameter
units: 345062
value: 3.5998992E-16

349274
type: SpeciesReference
stoichiometry: 1.0
species: 764136

764136
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

349262
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349250
type: SpeciesReference
stoichiometry: 1.0
species: 767376

767376
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

775635
type: Reaction
kinetic law: 359539
product: 359527
product: 359515
reactant: 359503
fast: false
reversible: false

359539
type: KineticLaw
local parameters: 831388
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx

831388
type: LocalParameter
units: 344978
value: 1.8E-16

359527
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359515
type: SpeciesReference
stoichiometry: 1.0
species: 767296

767296
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

359503
type: SpeciesReference
stoichiometry: 1.0
species: 767756

767756
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

773756
type: Reaction
kinetic law: 354286
product: 354274
product: 354262
reactant: 354250
fast: false
reversible: false

354286
type: KineticLaw
local parameters: 830904
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx

830904
type: LocalParameter
units: 344978
value: 5.0E-18

354274
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354262
type: SpeciesReference
stoichiometry: 1.0
species: 768756

768756
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

354250
type: SpeciesReference
stoichiometry: 1.0
species: 766156

771776
type: Reaction
kinetic law: 349478
product: 349466
reactant: 349454
reactant: 349442
fast: false
reversible: true

349478
type: KineticLaw
local parameters: 830457
local parameters: 830454
notes: k1*AMPAR_slash_A_B831_star_845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx

830457
type: LocalParameter
units: 344978
value: 2.16E-15

830454
type: LocalParameter
units: 345062
value: 3.5998992E-16

349466
type: SpeciesReference
stoichiometry: 1.0
species: 764176

764176
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

349454
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349442
type: SpeciesReference
stoichiometry: 1.0
species: 767476

767476
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

776955
type: Reaction
kinetic law: 362730
product: 362718
product: 362706
reactant: 362694
fast: false
reversible: false

362730
type: KineticLaw
local parameters: 831685
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx

831685
type: LocalParameter
units: 344978
value: 6.0E-17

362718
type: SpeciesReference
stoichiometry: 1.0
species: 769456

769456
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

362706
type: SpeciesReference
stoichiometry: 1.0
species: 765816

765816
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

362694
type: SpeciesReference
stoichiometry: 1.0
species: 768456

768456
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

764216
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

763777
type: Compartment
constant: true
size: 5.0E-15
spatial dimensions: 3.0

775155
type: Reaction
kinetic law: 358351
product: 358339
product: 358327
reactant: 358315
fast: false
reversible: false

358351
type: KineticLaw
local parameters: 831280
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx

831280
type: LocalParameter
units: 344978
value: 3.5E-18

358339
type: SpeciesReference
stoichiometry: 1.0
species: 766376

358327
type: SpeciesReference
stoichiometry: 1.0
species: 768536

768536
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

358315
type: SpeciesReference
stoichiometry: 1.0
species: 767096

767096
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

767016
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

773296
type: Reaction
kinetic law: 353178
product: 353166
reactant: 353154
reactant: 353142
fast: false
reversible: true

353178
type: KineticLaw
local parameters: 830802
local parameters: 830799
notes: k1*CaMKII_minus_CaM_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx

830802
type: LocalParameter
units: 344978
value: 2.0E-17

830799
type: LocalParameter
units: 345062
value: 4.99998E-20

353166
type: SpeciesReference
stoichiometry: 1.0
species: 765856

765856
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

353154
type: SpeciesReference
stoichiometry: 1.0
species: 769096

769096
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763776

353142
type: SpeciesReference
stoichiometry: 1.0
species: 765756

765756
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

772696
type: Reaction
kinetic law: 351725
product: 351713
reactant: 351701
reactant: 351689
fast: false
reversible: true

351725
type: KineticLaw
local parameters: 830664
local parameters: 830661
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx

830664
type: LocalParameter
units: 344978
value: 1.8E-16

830661
type: LocalParameter
units: 345062
value: 9.91197E-19

351713
type: SpeciesReference
stoichiometry: 1.0
species: 764716

764716
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.44537037037037E-8
initial amount: NaN
in compartment: 763757

351701
type: SpeciesReference
stoichiometry: 1.0
species: 769036

769036
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

351689
type: SpeciesReference
stoichiometry: 1.0
species: 764616

764616
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

775175
type: Reaction
kinetic law: 358400
product: 358388
reactant: 358376
reactant: 358363
fast: false
reversible: true

358400
type: KineticLaw
local parameters: 831286
local parameters: 831283
notes: k1*CaMKII_minus_thr305_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

831286
type: LocalParameter
units: 344978
value: 8.0E-18

831283
type: LocalParameter
units: 345062
value: 4.99998E-18

358388
type: SpeciesReference
stoichiometry: 1.0
species: 767116

767116
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

358376
type: SpeciesReference
stoichiometry: 1.0
species: 766376

358363
type: SpeciesReference
stoichiometry: 1.0
species: 768836

768836
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

775435
type: Reaction
kinetic law: 359054
product: 359042
product: 359030
reactant: 359018
fast: false
reversible: false

359054
type: KineticLaw
local parameters: 831343
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx

831343
type: LocalParameter
units: 344978
value: 6.03E-17

359042
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359030
type: SpeciesReference
stoichiometry: 1.0
species: 764856

764856
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 763757

359018
type: SpeciesReference
stoichiometry: 1.0
species: 767656

767656
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

774935
type: Reaction
kinetic law: 357821
product: 357808
reactant: 357796
reactant: 357784
fast: false
reversible: true

357821
type: KineticLaw
local parameters: 831232
local parameters: 831229
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx

831232
type: LocalParameter
units: 344978
value: 1.4E-17

831229
type: LocalParameter
units: 345062
value: 8.7498E-18

357808
type: SpeciesReference
stoichiometry: 1.0
species: 766996

766996
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

357796
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357784
type: SpeciesReference
stoichiometry: 1.0
species: 768636

768596
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

765176
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

765356
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

774436
type: Reaction
kinetic law: 356271
product: 356259
reactant: 356247
reactant: 356235
fast: false
reversible: true

356271
type: KineticLaw
local parameters: 831088
local parameters: 831085
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx

831088
type: LocalParameter
units: 344978
value: 1.4E-17

831085
type: LocalParameter
units: 345062
value: 8.7498E-18

356259
type: SpeciesReference
stoichiometry: 1.0
species: 766676

766676
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

356247
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356235
type: SpeciesReference
stoichiometry: 1.0
species: 768616

773776
type: Reaction
kinetic law: 354334
product: 354322
reactant: 354310
reactant: 354298
fast: false
reversible: true

354334
type: KineticLaw
local parameters: 830910
local parameters: 830907
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx

830910
type: LocalParameter
units: 344978
value: 2.0E-17

830907
type: LocalParameter
units: 345062
value: 2.77776E-19

354322
type: SpeciesReference
stoichiometry: 1.0
species: 766176

766176
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 763776

354310
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354298
type: SpeciesReference
stoichiometry: 1.0
species: 768676

768676
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

773316
type: Reaction
kinetic law: 353227
product: 353214
product: 353202
reactant: 353190
fast: false
reversible: false

353227
type: KineticLaw
local parameters: 830805
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx

830805
type: LocalParameter
units: 344978
value: 5.0E-18

353214
type: SpeciesReference
stoichiometry: 1.0
species: 769096

353202
type: SpeciesReference
stoichiometry: 1.0
species: 765736

353190
type: SpeciesReference
stoichiometry: 1.0
species: 765856

767496
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

771376
type: Reaction
kinetic law: 348512
product: 348500
reactant: 348488
reactant: 348476
fast: false
reversible: true

348512
type: KineticLaw
local parameters: 830367
local parameters: 830364
notes: k1*AMPAR_slash_A_B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx

830367
type: LocalParameter
units: 344978
value: 2.16E-15

830364
type: LocalParameter
units: 345062
value: 3.5998992E-16

348500
type: SpeciesReference
stoichiometry: 1.0
species: 764017

764017
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

348488
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348476
type: SpeciesReference
stoichiometry: 1.0
species: 767296

768396
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

774236
type: Reaction
kinetic law: 355449
product: 355437
product: 355424
reactant: 355412
fast: false
reversible: false

355449
type: KineticLaw
local parameters: 831010
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx

831010
type: LocalParameter
units: 344978
value: 1.7E-18

355437
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355424
type: SpeciesReference
stoichiometry: 1.0
species: 768596

355412
type: SpeciesReference
stoichiometry: 1.0
species: 766496

776595
type: Reaction
kinetic law: 361858
product: 361846
product: 361834
reactant: 361822
fast: false
reversible: false

361858
type: KineticLaw
local parameters: 831604
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx

831604
type: LocalParameter
units: 344978
value: 1.8E-16

361846
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361834
type: SpeciesReference
stoichiometry: 1.0
species: 768736

768736
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

361822
type: SpeciesReference
stoichiometry: 1.0
species: 768236

768236
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

766016
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 763776

774276
type: Reaction
kinetic law: 355596
product: 355583
reactant: 355570
reactant: 355558
fast: false
reversible: true

355596
type: KineticLaw
local parameters: 831025
local parameters: 831022
notes: k1*AMPAR_memb_slash_A_B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx

831025
type: LocalParameter
units: 344978
value: 6.8E-18

831022
type: LocalParameter
units: 345062
value: 8.7498E-18

355583
type: SpeciesReference
stoichiometry: 1.0
species: 766536

766536
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

355570
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355558
type: SpeciesReference
stoichiometry: 1.0
species: 768656

768656
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

765116
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00691
initial amount: NaN
in compartment: 763757

771856
type: Reaction
kinetic law: 349672
product: 349660
reactant: 349648
reactant: 349636
fast: false
reversible: true

349672
type: KineticLaw
local parameters: 830475
local parameters: 830472
notes: k1*AMPAR_slash_A845_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx

830475
type: LocalParameter
units: 344978
value: 2.16E-15

830472
type: LocalParameter
units: 345062
value: 3.5998992E-16

349660
type: SpeciesReference
stoichiometry: 1.0
species: 764196

764196
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

349648
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349636
type: SpeciesReference
stoichiometry: 1.0
species: 767336

767336
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

765896
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

766916
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

769316
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

770236
type: Reaction
kinetic law: 345931
product: 345919
reactant: 345907
reactant: 345895
notes: Hasler et al FASEB J 6:2734-2741 1992 say Kd =1e-7M for type II, 5.6e-8 M for type I. Take mean which comes to 2e-13 #/cell Smith et al PNAS USA 78:3 1591-1595 1981 have better data. First kf/kb=2.1e7/M = 3.5e-5 (#/cell). Ogreid and Doskeland Febs Lett 129:2 287-292 1981 have figs suggesting time course of complete assoc is < 1 min.
fast: false
reversible: true

345931
type: KineticLaw
local parameters: 830049
local parameters: 830046
notes: kf*PKA_slash_R2C2*cAMP-kb*PKA_slash_R2C2_minus_cAMP

830049
type: LocalParameter
units: 344978
value: 2.97E-15

830046
type: LocalParameter
units: 345062
value: 4.86E-15

345919
type: SpeciesReference
stoichiometry: 1.0
species: 765296

765296
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

345907
type: SpeciesReference
stoichiometry: 1.0
species: 763916

345895
type: SpeciesReference
stoichiometry: 1.0
species: 765276

765276
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: 763757

766736
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

770436
type: Reaction
kinetic law: 346387
product: 346375
reactant: 346363
reactant: 346351
notes: For olf epi PDE1, affinity is 7 nM. Assume same for brain. Reaction should be pretty fast. Assume kb = 5/sec. Then kf = 5 / (0.007 * 6e5) = 1.2e-3
fast: false
reversible: true

346387
type: KineticLaw
local parameters: 830109
local parameters: 830106
notes: kf*AC_slash_PDE1*CaM_minus_Ca4-kb*AC_slash_CaM_dot_PDE1

830109
type: LocalParameter
units: 344978
value: 4.5E-16

830106
type: LocalParameter
units: 345062
value: 6.479838E-14

346375
type: SpeciesReference
stoichiometry: 1.0
species: 765676

765676
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

346363
type: SpeciesReference
stoichiometry: 1.0
species: 763796

346351
type: SpeciesReference
stoichiometry: 1.0
species: 765636

764016
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

768096
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

766936
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

774576
type: Reaction
kinetic law: 356809
product: 356797
product: 356785
reactant: 356773
fast: false
reversible: false

356809
type: KineticLaw
local parameters: 831136
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx

831136
type: LocalParameter
units: 344978
value: 1.7E-18

356797
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356785
type: SpeciesReference
stoichiometry: 1.0
species: 768556

768556
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

356773
type: SpeciesReference
stoichiometry: 1.0
species: 766776

766776
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

771396
type: Reaction
kinetic law: 348562
product: 348549
product: 348537
reactant: 348524
fast: false
reversible: false

348562
type: KineticLaw
local parameters: 830370
notes: k3*PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx

830370
type: LocalParameter
units: 344978
value: 5.4E-16

348549
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348537
type: SpeciesReference
stoichiometry: 1.0
species: 767336

348524
type: SpeciesReference
stoichiometry: 1.0
species: 764017

772836
type: Reaction
kinetic law: 352064
product: 352052
product: 352040
reactant: 352028
fast: false
reversible: false

352064
type: KineticLaw
local parameters: 830694
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx

830694
type: LocalParameter
units: 344978
value: 1.8E-16

352052
type: SpeciesReference
stoichiometry: 1.0
species: 765076

352040
type: SpeciesReference
stoichiometry: 1.0
species: 764996

764996
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 763757

352028
type: SpeciesReference
stoichiometry: 1.0
species: 765096

765096
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.99333333333333E-6
initial amount: NaN
in compartment: 763757

765036
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

764556
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

774435
type: Reaction
kinetic law: 356223
product: 356211
product: 356199
reactant: 356187
fast: false
reversible: false

356223
type: KineticLaw
local parameters: 831082
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx

831082
type: LocalParameter
units: 344978
value: 3.5E-18

356211
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356199
type: SpeciesReference
stoichiometry: 1.0
species: 768656

356187
type: SpeciesReference
stoichiometry: 1.0
species: 766656

766656
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

776235
type: Reaction
kinetic law: 360989
product: 360977
product: 360965
reactant: 360953
fast: false
reversible: false

360989
type: KineticLaw
local parameters: 831523
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx

831523
type: LocalParameter
units: 344978
value: 1.8E-16

360977
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360965
type: SpeciesReference
stoichiometry: 1.0
species: 767576

767576
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

360953
type: SpeciesReference
stoichiometry: 1.0
species: 768056

772436
type: Reaction
kinetic law: 351090
product: 351077
product: 351065
reactant: 351052
fast: false
reversible: false

351090
type: KineticLaw
local parameters: 830604
notes: k3*PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx

830604
type: LocalParameter
units: 344978
value: 5.4E-16

351077
type: SpeciesReference
stoichiometry: 1.0
species: 763956

351065
type: SpeciesReference
stoichiometry: 1.0
species: 768736

351052
type: SpeciesReference
stoichiometry: 1.0
species: 764476

764476
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

770576
type: Reaction
kinetic law: 346714
product: 346702
reactant: 346690
reactant: 346678
notes: Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
fast: false
reversible: true

346714
type: KineticLaw
local parameters: 830151
local parameters: 830148
notes: kf*CaMKII_minus_thr286_minus_PSD*CaM_minus_Ca4_minus_PSD-kb*CaMKII_minus_thr286_minus_CaM_minus_PSD

830151
type: LocalParameter
units: 344978
value: 1.0E-18

830148
type: LocalParameter
units: 345062
value: 1.00002E-14

346702
type: SpeciesReference
stoichiometry: 1.0
species: 765736

346690
type: SpeciesReference
stoichiometry: 1.0
species: 765936

765936
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

346678
type: SpeciesReference
stoichiometry: 1.0
species: 765776

765776
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

768196
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

769276
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

770816
type: Reaction
kinetic law: 347231
product: 347219
reactant: 347207
fast: false
reversible: true

347231
type: KineticLaw
local parameters: 830223
local parameters: 830220
notes: kf*AMPAR_slash_A845_star__B831_star_845_star_-kb*AMPAR_slash_AMPAR_deg

830223
type: LocalParameter
units: 344978
value: 0.0

830220
type: LocalParameter
units: 344978
value: 3.24E-21

347219
type: SpeciesReference
stoichiometry: 1.0
species: 768896

347207
type: SpeciesReference
stoichiometry: 1.0
species: 767436

767436
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

776995
type: Reaction
kinetic law: 362826
product: 362814
product: 362802
reactant: 362790
fast: false
reversible: false

362826
type: KineticLaw
local parameters: 831694
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx

831694
type: LocalParameter
units: 344978
value: 5.0E-18

362814
type: SpeciesReference
stoichiometry: 1.0
species: 769456

362802
type: SpeciesReference
stoichiometry: 1.0
species: 765736

362790
type: SpeciesReference
stoichiometry: 1.0
species: 768476

768476
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

765696
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

764076
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

776835
type: Reaction
kinetic law: 362441
product: 362429
product: 362417
reactant: 362405
fast: false
reversible: false

362441
type: KineticLaw
local parameters: 831658
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx

831658
type: LocalParameter
units: 344978
value: 1.8E-16

362429
type: SpeciesReference
stoichiometry: 1.0
species: 767636

362417
type: SpeciesReference
stoichiometry: 1.0
species: 768576

362405
type: SpeciesReference
stoichiometry: 1.0
species: 768356

768356
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

772176
type: Reaction
kinetic law: 350458
product: 350445
reactant: 350432
reactant: 350419
fast: false
reversible: true

350458
type: KineticLaw
local parameters: 830547
local parameters: 830544
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx

830547
type: LocalParameter
units: 344978
value: 2.16E-15

830544
type: LocalParameter
units: 345062
value: 3.999888E-17

350445
type: SpeciesReference
stoichiometry: 1.0
species: 764356

764356
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

350432
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350419
type: SpeciesReference
stoichiometry: 1.0
species: 768716

773236
type: Reaction
kinetic law: 353034
product: 353022
product: 353010
reactant: 352998
fast: false
reversible: false

353034
type: KineticLaw
local parameters: 830787
notes: k3*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx

830787
type: LocalParameter
units: 344978
value: 9.0E-16

353022
type: SpeciesReference
stoichiometry: 1.0
species: 765676

353010
type: SpeciesReference
stoichiometry: 1.0
species: 765536

352998
type: SpeciesReference
stoichiometry: 1.0
species: 765696

772456
type: Reaction
kinetic law: 351139
product: 351127
reactant: 351115
reactant: 351102
fast: false
reversible: true

351139
type: KineticLaw
local parameters: 830610
local parameters: 830607
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx

830610
type: LocalParameter
units: 344978
value: 2.16E-15

830607
type: LocalParameter
units: 345062
value: 3.999888E-17

351127
type: SpeciesReference
stoichiometry: 1.0
species: 764496

764496
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

351115
type: SpeciesReference
stoichiometry: 1.0
species: 763956

351102
type: SpeciesReference
stoichiometry: 1.0
species: 768556

770176
type: Reaction
kinetic law: 345786
product: 345774
reactant: 345762
reactant: 345750
notes: This process is probably much more complicated and involves CaM. However, as I can\'t find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11
fast: false
reversible: true

345786
type: KineticLaw
local parameters: 830031
local parameters: 830028
notes: kf*Ca^2*PP2B_slash_CaNAB_minus_Ca2-kb*CaNAB_minus_Ca4

830031
type: LocalParameter
units: 344978
value: 9.0E-17

830028
type: LocalParameter
units: 345014
value: 3.24008424E-16

345050
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

345038
type: SBMLUnit
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE

345026
type: SBMLUnit
exponent: 3.0
scale: 0
multipler: 1.0
kind: LITRE

345774
type: SpeciesReference
stoichiometry: 1.0
species: 765176

345762
type: SpeciesReference
stoichiometry: 1.0
species: 765256

765256
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

345750
type: SpeciesReference
stoichiometry: 2.0
species: 763936

765616
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

774476
type: Reaction
kinetic law: 356472
product: 356459
reactant: 356446
reactant: 356433
fast: false
reversible: true

356472
type: KineticLaw
local parameters: 831106
local parameters: 831103
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx

831106
type: LocalParameter
units: 344978
value: 6.8E-18

831103
type: LocalParameter
units: 345062
value: 8.7498E-18

356459
type: SpeciesReference
stoichiometry: 1.0
species: 766716

766716
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

356446
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356433
type: SpeciesReference
stoichiometry: 1.0
species: 768796

768796
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

772496
type: Reaction
kinetic law: 351235
product: 351223
reactant: 351211
reactant: 351199
fast: false
reversible: true

351235
type: KineticLaw
local parameters: 830619
local parameters: 830616
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx

830619
type: LocalParameter
units: 344978
value: 2.16E-15

830616
type: LocalParameter
units: 345062
value: 3.999888E-17

351223
type: SpeciesReference
stoichiometry: 1.0
species: 764516

764516
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

351211
type: SpeciesReference
stoichiometry: 1.0
species: 763956

351199
type: SpeciesReference
stoichiometry: 1.0
species: 768756

773996
type: Reaction
kinetic law: 354867
product: 354855
product: 354843
reactant: 354831
fast: false
reversible: false

354867
type: KineticLaw
local parameters: 830956
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx

830956
type: LocalParameter
units: 344978
value: 5.0E-18

354855
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354843
type: SpeciesReference
stoichiometry: 1.0
species: 768576

354831
type: SpeciesReference
stoichiometry: 1.0
species: 766276

766276
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 763776

773536
type: Reaction
kinetic law: 353758
product: 353746
reactant: 353734
reactant: 353722
fast: false
reversible: true

353758
type: KineticLaw
local parameters: 830856
local parameters: 830853
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx

830856
type: LocalParameter
units: 344978
value: 2.0E-17

830853
type: LocalParameter
units: 345062
value: 2.77776E-19

353746
type: SpeciesReference
stoichiometry: 1.0
species: 766056

766056
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 763776

353734
type: SpeciesReference
stoichiometry: 1.0
species: 769136

353722
type: SpeciesReference
stoichiometry: 1.0
species: 768696

768696
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

770836
type: Reaction
kinetic law: 347267
product: 347255
reactant: 347243
fast: false
reversible: true

347267
type: KineticLaw
local parameters: 830229
local parameters: 830226
notes: kf*AMPAR_slash_A831_star_845_star__B845_star_-kb*AMPAR_slash_AMPAR_deg

830229
type: LocalParameter
units: 344978
value: 0.0

830226
type: LocalParameter
units: 344978
value: 3.24E-21

347255
type: SpeciesReference
stoichiometry: 1.0
species: 768896

347243
type: SpeciesReference
stoichiometry: 1.0
species: 767416

767416
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

765376
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

772776
type: Reaction
kinetic law: 351918
product: 351906
reactant: 351894
reactant: 351882
fast: false
reversible: true

351918
type: KineticLaw
local parameters: 830682
local parameters: 830679
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx

830682
type: LocalParameter
units: 344978
value: 1.8E-16

830679
type: LocalParameter
units: 345062
value: 6.428808E-19

351906
type: SpeciesReference
stoichiometry: 1.0
species: 764756

764756
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.89444444444444E-5
initial amount: NaN
in compartment: 763757

351894
type: SpeciesReference
stoichiometry: 1.0
species: 769056

769056
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763757

351882
type: SpeciesReference
stoichiometry: 1.0
species: 764616

767796
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

776135
type: Reaction
kinetic law: 360747
product: 360735
reactant: 360723
reactant: 360710
fast: false
reversible: true

360747
type: KineticLaw
local parameters: 831502
local parameters: 831499
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx

831502
type: LocalParameter
units: 344978
value: 7.2E-16

831499
type: LocalParameter
units: 345062
value: 1.8106416E-16

360735
type: SpeciesReference
stoichiometry: 1.0
species: 768016

768016
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

360723
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360710
type: SpeciesReference
stoichiometry: 1.0
species: 767416

765196
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

767716
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

776155
type: Reaction
kinetic law: 360795
product: 360783
product: 360771
reactant: 360759
fast: false
reversible: false

360795
type: KineticLaw
local parameters: 831505
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx

831505
type: LocalParameter
units: 344978
value: 1.8E-16

360783
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360771
type: SpeciesReference
stoichiometry: 1.0
species: 767356

767356
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

360759
type: SpeciesReference
stoichiometry: 1.0
species: 768016

775095
type: Reaction
kinetic law: 358207
product: 358195
reactant: 358183
reactant: 358171
fast: false
reversible: true

358207
type: KineticLaw
local parameters: 831268
local parameters: 831265
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx

831268
type: LocalParameter
units: 344978
value: 1.4E-17

831265
type: LocalParameter
units: 345062
value: 8.7498E-18

358195
type: SpeciesReference
stoichiometry: 1.0
species: 767076

767076
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

358183
type: SpeciesReference
stoichiometry: 1.0
species: 766376

358171
type: SpeciesReference
stoichiometry: 1.0
species: 768636

774495
type: Reaction
kinetic law: 356521
product: 356509
product: 356497
reactant: 356485
fast: false
reversible: false

356521
type: KineticLaw
local parameters: 831109
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx

831109
type: LocalParameter
units: 344978
value: 1.7E-18

356509
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356497
type: SpeciesReference
stoichiometry: 1.0
species: 768736

356485
type: SpeciesReference
stoichiometry: 1.0
species: 766716

768376
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

774036
type: Reaction
kinetic law: 354963
product: 354951
product: 354939
reactant: 354927
fast: false
reversible: false

354963
type: KineticLaw
local parameters: 830965
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

830965
type: LocalParameter
units: 344978
value: 2.0E-18

354951
type: SpeciesReference
stoichiometry: 1.0
species: 766376

354939
type: SpeciesReference
stoichiometry: 1.0
species: 765756

354927
type: SpeciesReference
stoichiometry: 1.0
species: 766396

766396
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

772096
type: Reaction
kinetic law: 350254
product: 350242
reactant: 350230
reactant: 350218
fast: false
reversible: true

350254
type: KineticLaw
local parameters: 830529
local parameters: 830526
notes: k1*AMPAR_memb_slash_A_B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx

830529
type: LocalParameter
units: 344978
value: 2.16E-15

830526
type: LocalParameter
units: 345062
value: 3.999888E-17

350242
type: SpeciesReference
stoichiometry: 1.0
species: 764316

764316
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

350230
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350218
type: SpeciesReference
stoichiometry: 1.0
species: 768516

773556
type: Reaction
kinetic law: 353806
product: 353794
product: 353782
reactant: 353770
fast: false
reversible: false

353806
type: KineticLaw
local parameters: 830859
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx

830859
type: LocalParameter
units: 344978
value: 5.0E-18

353794
type: SpeciesReference
stoichiometry: 1.0
species: 769136

353782
type: SpeciesReference
stoichiometry: 1.0
species: 768796

353770
type: SpeciesReference
stoichiometry: 1.0
species: 766056

774815
type: Reaction
kinetic law: 357530
product: 357518
reactant: 357506
reactant: 357494
fast: false
reversible: true

357530
type: KineticLaw
local parameters: 831205
local parameters: 831202
notes: k1*AMPAR_memb_slash_A_B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx

831205
type: LocalParameter
units: 344978
value: 1.4E-17

831202
type: LocalParameter
units: 345062
value: 8.7498E-18

357518
type: SpeciesReference
stoichiometry: 1.0
species: 766936

357506
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357494
type: SpeciesReference
stoichiometry: 1.0
species: 768556

772796
type: Reaction
kinetic law: 351968
product: 351955
product: 351942
reactant: 351930
fast: false
reversible: false

351968
type: KineticLaw
local parameters: 830685
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx

830685
type: LocalParameter
units: 344978
value: 4.5E-17

351955
type: SpeciesReference
stoichiometry: 1.0
species: 769056

351942
type: SpeciesReference
stoichiometry: 1.0
species: 764636

351930
type: SpeciesReference
stoichiometry: 1.0
species: 764756

344966
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

344954
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

774316
type: Reaction
kinetic law: 355694
product: 355682
reactant: 355670
reactant: 355658
fast: false
reversible: true

355694
type: KineticLaw
local parameters: 831034
local parameters: 831031
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx

831034
type: LocalParameter
units: 344978
value: 6.8E-18

831031
type: LocalParameter
units: 345062
value: 8.7498E-18

355682
type: SpeciesReference
stoichiometry: 1.0
species: 766556

766556
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

355670
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355658
type: SpeciesReference
stoichiometry: 1.0
species: 768776

771156
type: Reaction
kinetic law: 347979
product: 347967
product: 347955
reactant: 347943
fast: false
reversible: false

347979
type: KineticLaw
local parameters: 830316
notes: k3*PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

830316
type: LocalParameter
units: 344978
value: 2.25E-16

347967
type: SpeciesReference
stoichiometry: 1.0
species: 763797

347955
type: SpeciesReference
stoichiometry: 1.0
species: 764676

764676
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

347943
type: SpeciesReference
stoichiometry: 1.0
species: 763856

763856
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

772336
type: Reaction
kinetic law: 350845
product: 350832
reactant: 350820
reactant: 350808
fast: false
reversible: true

350845
type: KineticLaw
local parameters: 830583
local parameters: 830580
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx

830583
type: LocalParameter
units: 344978
value: 2.16E-15

830580
type: LocalParameter
units: 345062
value: 3.999888E-17

350832
type: SpeciesReference
stoichiometry: 1.0
species: 764436

764436
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

350820
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350808
type: SpeciesReference
stoichiometry: 1.0
species: 768736

774835
type: Reaction
kinetic law: 357578
product: 357566
product: 357554
reactant: 357542
fast: false
reversible: false

357578
type: KineticLaw
local parameters: 831208
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx

831208
type: LocalParameter
units: 344978
value: 3.5E-18

357566
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357554
type: SpeciesReference
stoichiometry: 1.0
species: 768516

357542
type: SpeciesReference
stoichiometry: 1.0
species: 766936

764836
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

769336
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

765216
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

770776
type: Reaction
kinetic law: 347159
product: 347147
product: 347135
reactant: 347123
fast: false
reversible: true

347159
type: KineticLaw
local parameters: 830211
local parameters: 830208
notes: kf*AMPAR_memb_slash_A_B-kb*AMPAR_slash_A_B*Anchor

830211
type: LocalParameter
units: 345062
value: 0.0

830208
type: LocalParameter
units: 344978
value: 8.0E-21

347147
type: SpeciesReference
stoichiometry: 1.0
species: 768436

347135
type: SpeciesReference
stoichiometry: 1.0
species: 767296

347123
type: SpeciesReference
stoichiometry: 1.0
species: 768516

345123
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

769956
type: Reaction
kinetic law: 345279
product: 345266
reactant: 345253
reactant: 345240
notes: Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
fast: false
reversible: true

345279
type: KineticLaw
local parameters: 829965
local parameters: 829962
notes: kf*CaMKII_slash_CaMKII_minus_thr286*CaM_minus_Ca4-kb*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM

829965
type: LocalParameter
units: 344978
value: 9.0E-18

829962
type: LocalParameter
units: 345062
value: 9.001692E-14

345266
type: SpeciesReference
stoichiometry: 1.0
species: 764636

345253
type: SpeciesReference
stoichiometry: 1.0
species: 763796

345240
type: SpeciesReference
stoichiometry: 1.0
species: 764676

770316
type: Reaction
kinetic law: 346123
product: 346111
product: 346099
reactant: 346087
notes: This has to be fast, as the activation of PKA by cAMP is also fast. kf was 10
fast: false
reversible: true

346123
type: KineticLaw
local parameters: 830073
local parameters: 830070
notes: kf*PKA_slash_R2C2_minus_cAMP4-kb*PKA_minus_active*PKA_slash_R2C_minus_cAMP4

830073
type: LocalParameter
units: 345062
value: 1.6199838E-15

830070
type: LocalParameter
units: 344978
value: 5.4E-15

346111
type: SpeciesReference
stoichiometry: 1.0
species: 765376

346099
type: SpeciesReference
stoichiometry: 1.0
species: 763956

346087
type: SpeciesReference
stoichiometry: 1.0
species: 765356

773616
type: Reaction
kinetic law: 353950
product: 353938
reactant: 353926
reactant: 353914
fast: false
reversible: true

353950
type: KineticLaw
local parameters: 830874
local parameters: 830871
notes: k1*AMPAR_memb_slash_A845_star__B*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx

830874
type: LocalParameter
units: 344978
value: 2.0E-17

830871
type: LocalParameter
units: 345062
value: 2.77776E-19

353938
type: SpeciesReference
stoichiometry: 1.0
species: 766096

766096
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 763776

353926
type: SpeciesReference
stoichiometry: 1.0
species: 769136

353914
type: SpeciesReference
stoichiometry: 1.0
species: 768596

771636
type: Reaction
kinetic law: 349141
product: 349129
product: 349117
reactant: 349105
fast: false
reversible: false

349141
type: KineticLaw
local parameters: 830424
notes: k3*PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx

830424
type: LocalParameter
units: 344978
value: 5.4E-16

349129
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349117
type: SpeciesReference
stoichiometry: 1.0
species: 767476

349105
type: SpeciesReference
stoichiometry: 1.0
species: 764096

764096
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

773636
type: Reaction
kinetic law: 353998
product: 353986
product: 353974
reactant: 353962
fast: false
reversible: false

353998
type: KineticLaw
local parameters: 830877
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx

830877
type: LocalParameter
units: 344978
value: 5.0E-18

353986
type: SpeciesReference
stoichiometry: 1.0
species: 769136

353974
type: SpeciesReference
stoichiometry: 1.0
species: 768676

353962
type: SpeciesReference
stoichiometry: 1.0
species: 766096

776095
type: Reaction
kinetic law: 360650
product: 360638
reactant: 360626
reactant: 360614
fast: false
reversible: true

360650
type: KineticLaw
local parameters: 831493
local parameters: 831490
notes: k1*AMPAR_slash_A845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx

831493
type: LocalParameter
units: 344978
value: 7.2E-16

831490
type: LocalParameter
units: 345062
value: 1.8106416E-16

360638
type: SpeciesReference
stoichiometry: 1.0
species: 767996

767996
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

360626
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360614
type: SpeciesReference
stoichiometry: 1.0
species: 767396

767396
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

775475
type: Reaction
kinetic law: 359151
product: 359139
product: 359127
reactant: 359115
fast: false
reversible: false

359151
type: KineticLaw
local parameters: 831352
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx

831352
type: LocalParameter
units: 344978
value: 3.06E-17

359139
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359127
type: SpeciesReference
stoichiometry: 1.0
species: 764996

359115
type: SpeciesReference
stoichiometry: 1.0
species: 767676

767676
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

774336
type: Reaction
kinetic law: 355790
product: 355778
reactant: 355766
reactant: 355754
fast: false
reversible: true

355790
type: KineticLaw
local parameters: 831043
local parameters: 831040
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx

831043
type: LocalParameter
units: 344978
value: 6.8E-18

831040
type: LocalParameter
units: 345062
value: 8.7498E-18

355778
type: SpeciesReference
stoichiometry: 1.0
species: 766576

355766
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355754
type: SpeciesReference
stoichiometry: 1.0
species: 768776

774995
type: Reaction
kinetic law: 357966
product: 357954
product: 357942
reactant: 357929
fast: false
reversible: false

357966
type: KineticLaw
local parameters: 831244
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx

831244
type: LocalParameter
units: 344978
value: 3.5E-18

357954
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357942
type: SpeciesReference
stoichiometry: 1.0
species: 768556

357929
type: SpeciesReference
stoichiometry: 1.0
species: 767016

771236
type: Reaction
kinetic law: 348175
product: 348163
product: 348151
reactant: 348139
fast: false
reversible: false

348175
type: KineticLaw
local parameters: 830334
notes: k3*PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

830334
type: LocalParameter
units: 344978
value: 2.25E-16

348163
type: SpeciesReference
stoichiometry: 1.0
species: 763797

348151
type: SpeciesReference
stoichiometry: 1.0
species: 764596

764596
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 20.0
initial amount: NaN
in compartment: 763757

348139
type: SpeciesReference
stoichiometry: 1.0
species: 763896

763896
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

773936
type: Reaction
kinetic law: 354721
product: 354709
reactant: 354697
reactant: 354684
fast: false
reversible: true

354721
type: KineticLaw
local parameters: 830944
local parameters: 830941
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx

830944
type: LocalParameter
units: 344978
value: 2.0E-17

830941
type: LocalParameter
units: 345062
value: 2.77776E-19

354709
type: SpeciesReference
stoichiometry: 1.0
species: 766256

766256
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 763776

354697
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354684
type: SpeciesReference
stoichiometry: 1.0
species: 768616

763836
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

771996
type: Reaction
kinetic law: 350012
product: 349999
product: 349987
reactant: 349975
fast: false
reversible: false

350012
type: KineticLaw
local parameters: 830505
notes: k3*PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx

830505
type: LocalParameter
units: 344978
value: 5.4E-16

349999
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349987
type: SpeciesReference
stoichiometry: 1.0
species: 767456

349975
type: SpeciesReference
stoichiometry: 1.0
species: 764256

764256
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

768216
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

775815
type: Reaction
kinetic law: 359973
product: 359961
reactant: 359949
reactant: 359937
fast: false
reversible: true

359973
type: KineticLaw
local parameters: 831430
local parameters: 831427
notes: k1*AMPAR_slash_A831_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx

831430
type: LocalParameter
units: 344978
value: 7.2E-16

831427
type: LocalParameter
units: 345062
value: 1.8106416E-16

359961
type: SpeciesReference
stoichiometry: 1.0
species: 767856

767856
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

359949
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359937
type: SpeciesReference
stoichiometry: 1.0
species: 767596

767596
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

770336
type: Reaction
kinetic law: 346171
product: 346159
product: 346147
reactant: 346135
fast: false
reversible: true

346171
type: KineticLaw
local parameters: 830079
local parameters: 830076
notes: kf*PKA_slash_R2C_minus_cAMP4-kb*PKA_minus_active*PKA_slash_R2_minus_cAMP4

830079
type: LocalParameter
units: 345062
value: 1.6199838E-15

830076
type: LocalParameter
units: 344978
value: 5.4E-15

346159
type: SpeciesReference
stoichiometry: 1.0
species: 765396

765396
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

346147
type: SpeciesReference
stoichiometry: 1.0
species: 763956

346135
type: SpeciesReference
stoichiometry: 1.0
species: 765376

771756
type: Reaction
kinetic law: 349430
product: 349418
product: 349406
reactant: 349394
fast: false
reversible: false

349430
type: KineticLaw
local parameters: 830451
notes: k3*PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx

830451
type: LocalParameter
units: 344978
value: 5.4E-16

349418
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349406
type: SpeciesReference
stoichiometry: 1.0
species: 767416

349394
type: SpeciesReference
stoichiometry: 1.0
species: 764156

764156
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

771256
type: Reaction
kinetic law: 348223
product: 348211
reactant: 348199
reactant: 348187
notes: Same rates as PKA-phosph-I1
fast: false
reversible: true

348223
type: KineticLaw
local parameters: 830340
local parameters: 830337
notes: k1*AC_slash_cAMP_minus_PDE*PKA_minus_active-k2*PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx

830340
type: LocalParameter
units: 344978
value: 3.24E-15

830337
type: LocalParameter
units: 345062
value: 5.399946E-16

348211
type: SpeciesReference
stoichiometry: 1.0
species: 763976

763976
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

348199
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348187
type: SpeciesReference
stoichiometry: 1.0
species: 765556

768976
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 763776

769256
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

769296
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

765456
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

775075
type: Reaction
kinetic law: 358159
product: 358146
product: 358134
reactant: 358122
fast: false
reversible: false

358159
type: KineticLaw
local parameters: 831262
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx

831262
type: LocalParameter
units: 344978
value: 3.5E-18

358146
type: SpeciesReference
stoichiometry: 1.0
species: 766376

358134
type: SpeciesReference
stoichiometry: 1.0
species: 768716

358122
type: SpeciesReference
stoichiometry: 1.0
species: 767056

767056
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

775775
type: Reaction
kinetic law: 359877
product: 359865
reactant: 359853
reactant: 359841
fast: false
reversible: true

359877
type: KineticLaw
local parameters: 831421
local parameters: 831418
notes: k1*AMPAR_slash_A_B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx

831421
type: LocalParameter
units: 344978
value: 7.2E-16

831418
type: LocalParameter
units: 345062
value: 1.8106416E-16

359865
type: SpeciesReference
stoichiometry: 1.0
species: 767836

767836
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

359853
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359841
type: SpeciesReference
stoichiometry: 1.0
species: 767376

774616
type: Reaction
kinetic law: 356953
product: 356941
reactant: 356929
reactant: 356917
fast: false
reversible: true

356953
type: KineticLaw
local parameters: 831151
local parameters: 831148
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx

831151
type: LocalParameter
units: 344978
value: 6.8E-18

831148
type: LocalParameter
units: 345062
value: 8.7498E-18

356941
type: SpeciesReference
stoichiometry: 1.0
species: 766816

766816
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

356929
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356917
type: SpeciesReference
stoichiometry: 1.0
species: 768816

768816
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

773276
type: Reaction
kinetic law: 353130
product: 353118
product: 353106
reactant: 353094
fast: false
reversible: false

353130
type: KineticLaw
local parameters: 830796
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx

830796
type: LocalParameter
units: 344978
value: 6.0E-17

353118
type: SpeciesReference
stoichiometry: 1.0
species: 769096

353106
type: SpeciesReference
stoichiometry: 1.0
species: 765816

353094
type: SpeciesReference
stoichiometry: 1.0
species: 765836

771296
type: Reaction
kinetic law: 348319
product: 348307
reactant: 348295
reactant: 348283
notes: #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
fast: false
reversible: true

348319
type: KineticLaw
local parameters: 830349
local parameters: 830346
notes: k1*PP1_slash_I1*PKA_minus_active-k2*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx

830349
type: LocalParameter
units: 344978
value: 3.24E-15

830346
type: LocalParameter
units: 345062
value: 5.399946E-16

348307
type: SpeciesReference
stoichiometry: 1.0
species: 763996

763996
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

348295
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348283
type: SpeciesReference
stoichiometry: 1.0
species: 764996

772676
type: Reaction
kinetic law: 351676
product: 351664
product: 351651
reactant: 351639
fast: false
reversible: false

351676
type: KineticLaw
local parameters: 830658
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx

830658
type: LocalParameter
units: 344978
value: 5.4E-16

351664
type: SpeciesReference
stoichiometry: 1.0
species: 769036

351651
type: SpeciesReference
stoichiometry: 1.0
species: 764656

351639
type: SpeciesReference
stoichiometry: 1.0
species: 764696

764696
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6.3262962962963E-11
initial amount: NaN
in compartment: 763757

775415
type: Reaction
kinetic law: 359006
product: 358994
reactant: 358982
reactant: 358970
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true

359006
type: KineticLaw
local parameters: 831340
local parameters: 831337
notes: k1*CaM_slash_neurogranin_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx

831340
type: LocalParameter
units: 344978
value: 2.403E-16

831337
type: LocalParameter
units: 345062
value: 3.0024108E-17

358994
type: SpeciesReference
stoichiometry: 1.0
species: 767656

358982
type: SpeciesReference
stoichiometry: 1.0
species: 767636

358970
type: SpeciesReference
stoichiometry: 1.0
species: 764836

775995
type: Reaction
kinetic law: 360408
product: 360396
product: 360384
reactant: 360372
fast: false
reversible: false

360408
type: KineticLaw
local parameters: 831469
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx

831469
type: LocalParameter
units: 344978
value: 1.8E-16

360396
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360384
type: SpeciesReference
stoichiometry: 1.0
species: 767596

360372
type: SpeciesReference
stoichiometry: 1.0
species: 767936

767936
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

772216
type: Reaction
kinetic law: 350555
product: 350543
reactant: 350531
reactant: 350519
fast: false
reversible: true

350555
type: KineticLaw
local parameters: 830556
local parameters: 830553
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx

830556
type: LocalParameter
units: 344978
value: 2.16E-15

830553
type: LocalParameter
units: 345062
value: 3.999888E-17

350543
type: SpeciesReference
stoichiometry: 1.0
species: 764376

764376
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

350531
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350519
type: SpeciesReference
stoichiometry: 1.0
species: 768616

771556
type: Reaction
kinetic law: 348948
product: 348935
product: 348923
reactant: 348911
fast: false
reversible: false

348948
type: KineticLaw
local parameters: 830406
notes: k3*PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx

830406
type: LocalParameter
units: 344978
value: 5.4E-16

348935
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348923
type: SpeciesReference
stoichiometry: 1.0
species: 767376

348911
type: SpeciesReference
stoichiometry: 1.0
species: 764057

764057
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

776815
type: Reaction
kinetic law: 362392
product: 362380
reactant: 362368
reactant: 362355
fast: false
reversible: true

362392
type: KineticLaw
local parameters: 831655
local parameters: 831652
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx

831655
type: LocalParameter
units: 344978
value: 7.2E-16

831652
type: LocalParameter
units: 345062
value: 2.011824E-17

362380
type: SpeciesReference
stoichiometry: 1.0
species: 768356

362368
type: SpeciesReference
stoichiometry: 1.0
species: 767636

362355
type: SpeciesReference
stoichiometry: 1.0
species: 768636

766856
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

770716
type: Reaction
kinetic law: 347015
product: 347003
product: 346991
reactant: 346979
fast: false
reversible: true

347015
type: KineticLaw
local parameters: 830193
local parameters: 830190
notes: kf*AMPAR_memb_slash_A831_star__B831_star_-kb*AMPAR_slash_A831_star__B831_star_*Anchor

830193
type: LocalParameter
units: 345062
value: 0.0

830190
type: LocalParameter
units: 344978
value: 8.0E-21

347003
type: SpeciesReference
stoichiometry: 1.0
species: 768436

346991
type: SpeciesReference
stoichiometry: 1.0
species: 767556

767556
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

346979
type: SpeciesReference
stoichiometry: 1.0
species: 768576

773156
type: Reaction
kinetic law: 352841
product: 352829
product: 352817
reactant: 352805
fast: false
reversible: false

352841
type: KineticLaw
local parameters: 830769
notes: k3*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx

830769
type: LocalParameter
units: 344978
value: 1.8E-15

352829
type: SpeciesReference
stoichiometry: 1.0
species: 765596

765596
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

352817
type: SpeciesReference
stoichiometry: 1.0
species: 765536

352805
type: SpeciesReference
stoichiometry: 1.0
species: 765616

769396
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763757

774216
type: Reaction
kinetic law: 355399
product: 355386
reactant: 355374
reactant: 355362
fast: false
reversible: true

355399
type: KineticLaw
local parameters: 831007
local parameters: 831004
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx

831007
type: LocalParameter
units: 344978
value: 6.8E-18

831004
type: LocalParameter
units: 345062
value: 8.7498E-18

355386
type: SpeciesReference
stoichiometry: 1.0
species: 766496

355374
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355362
type: SpeciesReference
stoichiometry: 1.0
species: 768696

772236
type: Reaction
kinetic law: 350603
product: 350591
product: 350579
reactant: 350567
fast: false
reversible: false

350603
type: KineticLaw
local parameters: 830559
notes: k3*PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx

830559
type: LocalParameter
units: 344978
value: 5.4E-16

350591
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350579
type: SpeciesReference
stoichiometry: 1.0
species: 768776

350567
type: SpeciesReference
stoichiometry: 1.0
species: 764376

769996
type: Reaction
kinetic law: 345375
product: 345363
reactant: 345351
reactant: 345339
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true

345375
type: KineticLaw
local parameters: 829977
local parameters: 829974
notes: kf*CaM_minus_TR2_minus_Ca2*Ca-kb*CaM_minus_Ca3

829977
type: LocalParameter
units: 344978
value: 9.0E-16

829974
type: LocalParameter
units: 345062
value: 3.2400162E-16

345363
type: SpeciesReference
stoichiometry: 1.0
species: 764956

345351
type: SpeciesReference
stoichiometry: 1.0
species: 763936

345339
type: SpeciesReference
stoichiometry: 1.0
species: 764976

764976
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

774256
type: Reaction
kinetic law: 355497
product: 355485
reactant: 355473
reactant: 355461
fast: false
reversible: true

355497
type: KineticLaw
local parameters: 831016
local parameters: 831013
notes: k1*AMPAR_memb_slash_A845_star__B*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx

831016
type: LocalParameter
units: 344978
value: 6.8E-18

831013
type: LocalParameter
units: 345062
value: 8.7498E-18

355485
type: SpeciesReference
stoichiometry: 1.0
species: 766516

766516
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

355473
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355461
type: SpeciesReference
stoichiometry: 1.0
species: 768596

768136
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

768176
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

771836
type: Reaction
kinetic law: 349624
product: 349612
product: 349599
reactant: 349587
fast: false
reversible: false

349624
type: KineticLaw
local parameters: 830469
notes: k3*PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx

830469
type: LocalParameter
units: 344978
value: 5.4E-16

349612
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349599
type: SpeciesReference
stoichiometry: 1.0
species: 767456

349587
type: SpeciesReference
stoichiometry: 1.0
species: 764177

764177
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

767036
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

767956
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

774735
type: Reaction
kinetic law: 357338
product: 357326
reactant: 357314
reactant: 357302
fast: false
reversible: true

357338
type: KineticLaw
local parameters: 831187
local parameters: 831184
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx

831187
type: LocalParameter
units: 344978
value: 1.4E-17

831184
type: LocalParameter
units: 345062
value: 8.7498E-18

357326
type: SpeciesReference
stoichiometry: 1.0
species: 766896

766896
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

357314
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357302
type: SpeciesReference
stoichiometry: 1.0
species: 768796

763744
type: Compartment
constant: true
size: 1.0E-18
spatial dimensions: 3.0

773016
type: Reaction
kinetic law: 352499
product: 352487
reactant: 352475
reactant: 352463
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true

352499
type: KineticLaw
local parameters: 830736
local parameters: 830733
notes: k1*PP1_PSD_slash_I1_star_*CaNAB_minus_Ca4-k2*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx

830736
type: LocalParameter
units: 344978
value: 1.224E-17

830733
type: LocalParameter
units: 345062
value: 3.420036E-19

352487
type: SpeciesReference
stoichiometry: 1.0
species: 765216

352475
type: SpeciesReference
stoichiometry: 1.0
species: 765176

352463
type: SpeciesReference
stoichiometry: 1.0
species: 766316

766316
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

774275
type: Reaction
kinetic law: 355546
product: 355534
product: 355522
reactant: 355509
fast: false
reversible: false

355546
type: KineticLaw
local parameters: 831019
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx

831019
type: LocalParameter
units: 344978
value: 1.7E-18

355534
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355522
type: SpeciesReference
stoichiometry: 1.0
species: 768516

355509
type: SpeciesReference
stoichiometry: 1.0
species: 766516

773056
type: Reaction
kinetic law: 352597
modifier: 352585
product: 352572
reactant: 352559
notes: 17 Feb 2005 Halved Vmax as the amount of enzyme has been doubled to get an integer value in the spine. 18 Feb 2005. Updated Km from BRENDA: EC No 4.6.1.1 Rat Km: 0.95 mM Turnover 12/sec. Human Km: 0.3 mM 12 umol/min/mg for mammalia, turnover is 12/sec See PMID 8663304 by Dessauer and Gilman JBC 271 1996 Unfortunately turnover range is from 34 down to 0.1 in different studies, according to BRENDA.
fast: false
reversible: false

352597
type: KineticLaw
local parameters: 830745
local parameters: 830742
notes: kcat*AC_slash_AC1_minus_CaM*AC_slash_ATP/(Km+AC_slash_ATP)

830745
type: LocalParameter
units: 344942
value: 299.9976000192

830742
type: LocalParameter
units: 344978
value: 4.05E-16

352572
type: SpeciesReference
stoichiometry: 1.0
species: 763916

352559
type: SpeciesReference
stoichiometry: 1.0
species: 768856

768856
type: Species
notes: ATP is present in all cells between 2 and 10 mM. See Lehninger
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2000.0
initial amount: NaN
in compartment: 763757

770216
type: Reaction
kinetic law: 345882
product: 345870
reactant: 345858
reactant: 345846
fast: false
reversible: true

345882
type: KineticLaw
local parameters: 830043
local parameters: 830040
notes: kf*CaM_minus_Ca4*CaNAB_minus_Ca4-kb*CaM_Ca_n_minus_CaNAB

830043
type: LocalParameter
units: 344978
value: 9.0E-17

830040
type: LocalParameter
units: 345062
value: 5.399946E-14

345870
type: SpeciesReference
stoichiometry: 1.0
species: 767636

345858
type: SpeciesReference
stoichiometry: 1.0
species: 765176

345846
type: SpeciesReference
stoichiometry: 1.0
species: 763796

764816
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

774755
type: Reaction
kinetic law: 357386
product: 357374
product: 357362
reactant: 357350
fast: false
reversible: false

357386
type: KineticLaw
local parameters: 831190
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx

831190
type: LocalParameter
units: 344978
value: 3.5E-18

357374
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357362
type: SpeciesReference
stoichiometry: 1.0
species: 768696

357350
type: SpeciesReference
stoichiometry: 1.0
species: 766896

772816
type: Reaction
kinetic law: 352016
product: 352004
reactant: 351992
reactant: 351980
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true

352016
type: KineticLaw
local parameters: 830691
local parameters: 830688
notes: k1*PP1_slash_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx

830691
type: LocalParameter
units: 344978
value: 7.50006E-16

830688
type: LocalParameter
units: 345062
value: 5.81256E-17

352004
type: SpeciesReference
stoichiometry: 1.0
species: 765096

351992
type: SpeciesReference
stoichiometry: 1.0
species: 765076

351980
type: SpeciesReference
stoichiometry: 1.0
species: 765016

770496
type: Reaction
kinetic law: 346520
product: 346508
reactant: 346496
reactant: 346484
notes: Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers
fast: false
reversible: true

346520
type: KineticLaw
local parameters: 830127
local parameters: 830124
notes: kf*CaMKII_slash_CaMKII_minus_CaM*NMDAR-kb*CaMKII_minus_CaM_minus_PSD

830127
type: LocalParameter
units: 344978
value: 0.0

830124
type: LocalParameter
units: 345062
value: 1.08E-20

346508
type: SpeciesReference
stoichiometry: 1.0
species: 765756

346496
type: SpeciesReference
stoichiometry: 1.0
species: 767616

346484
type: SpeciesReference
stoichiometry: 1.0
species: 764616

770556
type: Reaction
kinetic law: 346666
product: 346653
product: 346640
reactant: 346628
notes: Same as for back_1
fast: false
reversible: true

346666
type: KineticLaw
local parameters: 830145
local parameters: 830142
notes: kf*CaMKII_minus_thr305_minus_PSD-kb*CaMKII_slash_CaMK_minus_thr305*NMDAR

830145
type: LocalParameter
units: 345062
value: 5.4E-21

830142
type: LocalParameter
units: 344978
value: 3.0E-18

346653
type: SpeciesReference
stoichiometry: 1.0
species: 767616

346640
type: SpeciesReference
stoichiometry: 1.0
species: 764776

346628
type: SpeciesReference
stoichiometry: 1.0
species: 768836

765956
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 763776

765916
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00254583333333333
initial amount: NaN
in compartment: 763776

772616
type: Reaction
kinetic law: 351529
product: 351517
reactant: 351505
reactant: 351493
fast: false
reversible: true

351529
type: KineticLaw
local parameters: 830646
local parameters: 830643
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx

830646
type: LocalParameter
units: 344978
value: 2.16E-15

830643
type: LocalParameter
units: 345062
value: 3.999888E-17

351517
type: SpeciesReference
stoichiometry: 1.0
species: 764576

764576
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

351505
type: SpeciesReference
stoichiometry: 1.0
species: 763956

351493
type: SpeciesReference
stoichiometry: 1.0
species: 768576

767876
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

776475
type: Reaction
kinetic law: 361569
product: 361557
product: 361545
reactant: 361532
fast: false
reversible: false

361569
type: KineticLaw
local parameters: 831577
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx

831577
type: LocalParameter
units: 344978
value: 1.8E-16

361557
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361545
type: SpeciesReference
stoichiometry: 1.0
species: 768616

361532
type: SpeciesReference
stoichiometry: 1.0
species: 768176

774116
type: Reaction
kinetic law: 355158
product: 355146
product: 355133
reactant: 355121
fast: false
reversible: false

355158
type: KineticLaw
local parameters: 830983
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

830983
type: LocalParameter
units: 344978
value: 2.0E-18

355146
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355133
type: SpeciesReference
stoichiometry: 1.0
species: 765776

355121
type: SpeciesReference
stoichiometry: 1.0
species: 766436

766436
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

764336
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

763816
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

768916
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763757

772956
type: Reaction
kinetic law: 352353
product: 352341
product: 352329
reactant: 352317
fast: false
reversible: false

352353
type: KineticLaw
local parameters: 830721
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx

830721
type: LocalParameter
units: 344978
value: 1.8E-16

352341
type: SpeciesReference
stoichiometry: 1.0
species: 765076

352329
type: SpeciesReference
stoichiometry: 1.0
species: 766356

766356
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

352317
type: SpeciesReference
stoichiometry: 1.0
species: 765156

765156
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00127907407407407
initial amount: NaN
in compartment: 763757

774395
type: Reaction
kinetic law: 356031
product: 356019
product: 356007
reactant: 355995
fast: false
reversible: false

356031
type: KineticLaw
local parameters: 831064
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx

831064
type: LocalParameter
units: 344978
value: 1.7E-18

356019
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356007
type: SpeciesReference
stoichiometry: 1.0
species: 768536

355995
type: SpeciesReference
stoichiometry: 1.0
species: 766616

766616
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

765476
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 763757

770936
type: Reaction
kinetic law: 347495
product: 347483
reactant: 347471
reactant: 347459
notes: Exo rates are scaled from earlier model versions to account for binding of anchor. We have about 200 molecules of anchor in the whole model. Here we select rates to give us a max of about 150 molecules of GluR at the synapse.
fast: false
reversible: true

347495
type: KineticLaw
local parameters: 830259
local parameters: 830256
notes: kf*AMPAR_slash_A845_star__B845_star_*Anchor-kb*AMPAR_memb_slash_A845_star__B845_star_

830259
type: LocalParameter
units: 344978
value: 8.0E-20

830256
type: LocalParameter
units: 345062
value: 1.08E-19

347483
type: SpeciesReference
stoichiometry: 1.0
species: 768696

347471
type: SpeciesReference
stoichiometry: 1.0
species: 768436

347459
type: SpeciesReference
stoichiometry: 1.0
species: 767396

776495
type: Reaction
kinetic law: 361617
product: 361605
reactant: 361593
reactant: 361581
fast: false
reversible: true

361617
type: KineticLaw
local parameters: 831583
local parameters: 831580
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx

831583
type: LocalParameter
units: 344978
value: 7.2E-16

831580
type: LocalParameter
units: 345062
value: 2.011824E-17

361605
type: SpeciesReference
stoichiometry: 1.0
species: 768196

361593
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361581
type: SpeciesReference
stoichiometry: 1.0
species: 768716

769416
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

776035
type: Reaction
kinetic law: 360504
product: 360492
product: 360480
reactant: 360468
fast: false
reversible: false

360504
type: KineticLaw
local parameters: 831478
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx

831478
type: LocalParameter
units: 344978
value: 1.8E-16

360492
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360480
type: SpeciesReference
stoichiometry: 1.0
species: 767476

360468
type: SpeciesReference
stoichiometry: 1.0
species: 767956

776755
type: Reaction
kinetic law: 362247
product: 362234
product: 362222
reactant: 362210
fast: false
reversible: false

362247
type: KineticLaw
local parameters: 831640
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx

831640
type: LocalParameter
units: 344978
value: 1.8E-16

362234
type: SpeciesReference
stoichiometry: 1.0
species: 767636

362222
type: SpeciesReference
stoichiometry: 1.0
species: 768756

362210
type: SpeciesReference
stoichiometry: 1.0
species: 768316

768316
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

766876
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

772276
type: Reaction
kinetic law: 350699
product: 350687
product: 350675
reactant: 350663
fast: false
reversible: false

350699
type: KineticLaw
local parameters: 830568
notes: k3*PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx

830568
type: LocalParameter
units: 344978
value: 5.4E-16

350687
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350675
type: SpeciesReference
stoichiometry: 1.0
species: 768716

350663
type: SpeciesReference
stoichiometry: 1.0
species: 764396

764396
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

776795
type: Reaction
kinetic law: 362343
product: 362331
product: 362319
reactant: 362307
fast: false
reversible: false

362343
type: KineticLaw
local parameters: 831649
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx

831649
type: LocalParameter
units: 344978
value: 1.8E-16

362331
type: SpeciesReference
stoichiometry: 1.0
species: 767636

362319
type: SpeciesReference
stoichiometry: 1.0
species: 768636

362307
type: SpeciesReference
stoichiometry: 1.0
species: 768336

768336
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

772556
type: Reaction
kinetic law: 351382
product: 351370
product: 351358
reactant: 351346
fast: false
reversible: false

351382
type: KineticLaw
local parameters: 830631
notes: k3*PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx

830631
type: LocalParameter
units: 344978
value: 5.4E-16

351370
type: SpeciesReference
stoichiometry: 1.0
species: 763956

351358
type: SpeciesReference
stoichiometry: 1.0
species: 768816

351346
type: SpeciesReference
stoichiometry: 1.0
species: 764536

774475
type: Reaction
kinetic law: 356420
product: 356407
product: 356394
reactant: 356381
fast: false
reversible: false

356420
type: KineticLaw
local parameters: 831100
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx

831100
type: LocalParameter
units: 344978
value: 3.5E-18

356407
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356394
type: SpeciesReference
stoichiometry: 1.0
species: 768516

356381
type: SpeciesReference
stoichiometry: 1.0
species: 766696

766696
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

776395
type: Reaction
kinetic law: 361375
product: 361363
product: 361351
reactant: 361339
fast: false
reversible: false

361375
type: KineticLaw
local parameters: 831559
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx

831559
type: LocalParameter
units: 344978
value: 1.8E-16

361363
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361351
type: SpeciesReference
stoichiometry: 1.0
species: 768516

361339
type: SpeciesReference
stoichiometry: 1.0
species: 768136

764936
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

769436
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

770956
type: Reaction
kinetic law: 347543
product: 347531
product: 347519
reactant: 347507
fast: false
reversible: true

347543
type: KineticLaw
local parameters: 830265
local parameters: 830262
notes: kf*CaMKII_minus_CaM_minus_PSD-kb*CaM_minus_Ca4_minus_PSD*CaMKII_minus_PSD

830265
type: LocalParameter
units: 345062
value: 0.0

830262
type: LocalParameter
units: 344978
value: 5.0E-17

347531
type: SpeciesReference
stoichiometry: 1.0
species: 765796

765796
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

347519
type: SpeciesReference
stoichiometry: 1.0
species: 765936

347507
type: SpeciesReference
stoichiometry: 1.0
species: 765756

765876
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

773796
type: Reaction
kinetic law: 354382
product: 354370
product: 354358
reactant: 354346
fast: false
reversible: false

354382
type: KineticLaw
local parameters: 830913
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx

830913
type: LocalParameter
units: 344978
value: 5.0E-18

354370
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354358
type: SpeciesReference
stoichiometry: 1.0
species: 768636

354346
type: SpeciesReference
stoichiometry: 1.0
species: 766176

772576
type: Reaction
kinetic law: 351430
product: 351418
reactant: 351406
reactant: 351394
fast: false
reversible: true

351430
type: KineticLaw
local parameters: 830637
local parameters: 830634
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx

830637
type: LocalParameter
units: 344978
value: 2.16E-15

830634
type: LocalParameter
units: 345062
value: 3.999888E-17

351418
type: SpeciesReference
stoichiometry: 1.0
species: 764556

351406
type: SpeciesReference
stoichiometry: 1.0
species: 763956

351394
type: SpeciesReference
stoichiometry: 1.0
species: 768576

767976
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

772116
type: Reaction
kinetic law: 350303
product: 350290
product: 350278
reactant: 350266
fast: false
reversible: false

350303
type: KineticLaw
local parameters: 830532
notes: k3*PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx

830532
type: LocalParameter
units: 344978
value: 5.4E-16

350290
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350278
type: SpeciesReference
stoichiometry: 1.0
species: 768596

350266
type: SpeciesReference
stoichiometry: 1.0
species: 764316

775695
type: Reaction
kinetic law: 359683
product: 359671
reactant: 359659
reactant: 359647
fast: false
reversible: true

359683
type: KineticLaw
local parameters: 831403
local parameters: 831400
notes: k1*AMPAR_slash_A845_star__B831_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx

831403
type: LocalParameter
units: 344978
value: 7.2E-16

831400
type: LocalParameter
units: 345062
value: 1.8106416E-16

359671
type: SpeciesReference
stoichiometry: 1.0
species: 767796

359659
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359647
type: SpeciesReference
stoichiometry: 1.0
species: 767536

769936
type: Reaction
kinetic law: 345227
product: 345214
reactant: 345201
reactant: 345188
notes: This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
fast: false
reversible: true

345227
type: KineticLaw
local parameters: 829959
local parameters: 829956
notes: kf*CaM_minus_Ca4*CaMKII_slash_CaMKII-kb*CaMKII_slash_CaMKII_minus_CaM

829959
type: LocalParameter
units: 344978
value: 4.5E-16

829956
type: LocalParameter
units: 345062
value: 4.4999712E-15

345214
type: SpeciesReference
stoichiometry: 1.0
species: 764616

345201
type: SpeciesReference
stoichiometry: 1.0
species: 764596

345188
type: SpeciesReference
stoichiometry: 1.0
species: 763796

771616
type: Reaction
kinetic law: 349093
product: 349080
reactant: 349068
reactant: 349056
fast: false
reversible: true

349093
type: KineticLaw
local parameters: 830421
local parameters: 830418
notes: k1*AMPAR_slash_A_B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx

830421
type: LocalParameter
units: 344978
value: 2.16E-15

830418
type: LocalParameter
units: 345062
value: 3.5998992E-16

349080
type: SpeciesReference
stoichiometry: 1.0
species: 764096

349068
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349056
type: SpeciesReference
stoichiometry: 1.0
species: 767516

765316
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

775455
type: Reaction
kinetic law: 359102
product: 359090
reactant: 359078
reactant: 359066
fast: false
reversible: true

359102
type: KineticLaw
local parameters: 831349
local parameters: 831346
notes: k1*PP1_slash_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx

831349
type: LocalParameter
units: 344978
value: 1.224E-16

831346
type: LocalParameter
units: 345062
value: 3.0779838E-17

359090
type: SpeciesReference
stoichiometry: 1.0
species: 767676

359078
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359066
type: SpeciesReference
stoichiometry: 1.0
species: 765016

774795
type: Reaction
kinetic law: 357482
product: 357470
product: 357458
reactant: 357446
fast: false
reversible: false

357482
type: KineticLaw
local parameters: 831199
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx

831199
type: LocalParameter
units: 344978
value: 3.5E-18

357470
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357458
type: SpeciesReference
stoichiometry: 1.0
species: 768596

357446
type: SpeciesReference
stoichiometry: 1.0
species: 766916

774635
type: Reaction
kinetic law: 357001
product: 356989
product: 356977
reactant: 356965
fast: false
reversible: false

357001
type: KineticLaw
local parameters: 831154
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx

831154
type: LocalParameter
units: 344978
value: 1.7E-18

356989
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356977
type: SpeciesReference
stoichiometry: 1.0
species: 768636

356965
type: SpeciesReference
stoichiometry: 1.0
species: 766816

769016
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.00925933333333333
initial amount: NaN
in compartment: 763777

773876
type: Reaction
kinetic law: 354575
product: 354563
product: 354551
reactant: 354539
fast: false
reversible: false

354575
type: KineticLaw
local parameters: 830929
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx

830929
type: LocalParameter
units: 344978
value: 5.0E-18

354563
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354551
type: SpeciesReference
stoichiometry: 1.0
species: 768816

354539
type: SpeciesReference
stoichiometry: 1.0
species: 766216

771896
type: Reaction
kinetic law: 349770
product: 349758
reactant: 349746
reactant: 349734
fast: false
reversible: true

349770
type: KineticLaw
local parameters: 830484
local parameters: 830481
notes: k1*AMPAR_slash_A831_star_845_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx

830484
type: LocalParameter
units: 344978
value: 2.16E-15

830481
type: LocalParameter
units: 345062
value: 3.5998992E-16

349758
type: SpeciesReference
stoichiometry: 1.0
species: 764216

349746
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349734
type: SpeciesReference
stoichiometry: 1.0
species: 767356

773916
type: Reaction
kinetic law: 354672
product: 354660
product: 354648
reactant: 354636
fast: false
reversible: false

354672
type: KineticLaw
local parameters: 830938
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx

830938
type: LocalParameter
units: 344978
value: 5.0E-18

354660
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354648
type: SpeciesReference
stoichiometry: 1.0
species: 768756

354636
type: SpeciesReference
stoichiometry: 1.0
species: 766236

766236
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 763776

775255
type: Reaction
kinetic law: 358593
product: 358580
reactant: 358568
reactant: 358556
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

358593
type: KineticLaw
local parameters: 831304
local parameters: 831301
notes: k1*CaM_slash_neurogranin_minus_CaM*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx

831304
type: LocalParameter
units: 344978
value: 1.26E-16

831301
type: LocalParameter
units: 345062
value: 5.507838E-18

358580
type: SpeciesReference
stoichiometry: 1.0
species: 767176

358568
type: SpeciesReference
stoichiometry: 1.0
species: 767136

767136
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 763757

358556
type: SpeciesReference
stoichiometry: 1.0
species: 764816

765716
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763777

773596
type: Reaction
kinetic law: 353902
product: 353890
product: 353878
reactant: 353866
fast: false
reversible: false

353902
type: KineticLaw
local parameters: 830868
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx

830868
type: LocalParameter
units: 344978
value: 5.0E-18

353890
type: SpeciesReference
stoichiometry: 1.0
species: 769136

353878
type: SpeciesReference
stoichiometry: 1.0
species: 768736

353866
type: SpeciesReference
stoichiometry: 1.0
species: 766076

766076
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 763776

766956
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

775755
type: Reaction
kinetic law: 359829
product: 359817
product: 359805
reactant: 359793
fast: false
reversible: false

359829
type: KineticLaw
local parameters: 831415
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx

831415
type: LocalParameter
units: 344978
value: 1.8E-16

359817
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359805
type: SpeciesReference
stoichiometry: 1.0
species: 767556

359793
type: SpeciesReference
stoichiometry: 1.0
species: 767816

767816
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

767896
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

773896
type: Reaction
kinetic law: 354624
product: 354612
reactant: 354599
reactant: 354587
fast: false
reversible: true

354624
type: KineticLaw
local parameters: 830935
local parameters: 830932
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx

830935
type: LocalParameter
units: 344978
value: 2.0E-17

830932
type: LocalParameter
units: 345062
value: 2.77776E-19

354612
type: SpeciesReference
stoichiometry: 1.0
species: 766236

354599
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354587
type: SpeciesReference
stoichiometry: 1.0
species: 768716

771316
type: Reaction
kinetic law: 348367
product: 348355
product: 348343
reactant: 348331
fast: false
reversible: false

348367
type: KineticLaw
local parameters: 830352
notes: k3*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx

830352
type: LocalParameter
units: 344978
value: 8.1E-16

348355
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348343
type: SpeciesReference
stoichiometry: 1.0
species: 765016

348331
type: SpeciesReference
stoichiometry: 1.0
species: 763996

771196
type: Reaction
kinetic law: 348077
product: 348065
product: 348053
reactant: 348040
fast: false
reversible: false

348077
type: KineticLaw
local parameters: 830325
notes: k3*PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

830325
type: LocalParameter
units: 344978
value: 2.25E-16

348065
type: SpeciesReference
stoichiometry: 1.0
species: 763797

348053
type: SpeciesReference
stoichiometry: 1.0
species: 764776

348040
type: SpeciesReference
stoichiometry: 1.0
species: 763876

769076
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

773436
type: Reaction
kinetic law: 353518
product: 353506
product: 353494
reactant: 353482
fast: false
reversible: false

353518
type: KineticLaw
local parameters: 830832
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx

830832
type: LocalParameter
units: 344978
value: 5.0E-18

353506
type: SpeciesReference
stoichiometry: 1.0
species: 769136

353494
type: SpeciesReference
stoichiometry: 1.0
species: 768716

353482
type: SpeciesReference
stoichiometry: 1.0
species: 765996

765996
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 763776

771496
type: Reaction
kinetic law: 348802
product: 348790
reactant: 348778
reactant: 348766
fast: false
reversible: true

348802
type: KineticLaw
local parameters: 830394
local parameters: 830391
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx

830394
type: LocalParameter
units: 344978
value: 2.16E-15

830391
type: LocalParameter
units: 345062
value: 3.5998992E-16

348790
type: SpeciesReference
stoichiometry: 1.0
species: 764056

764056
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

348778
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348766
type: SpeciesReference
stoichiometry: 1.0
species: 767556

772716
type: Reaction
kinetic law: 351773
product: 351761
product: 351749
reactant: 351737
fast: false
reversible: false

351773
type: KineticLaw
local parameters: 830667
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx

830667
type: LocalParameter
units: 344978
value: 4.5E-17

351761
type: SpeciesReference
stoichiometry: 1.0
species: 769036

351749
type: SpeciesReference
stoichiometry: 1.0
species: 764636

351737
type: SpeciesReference
stoichiometry: 1.0
species: 764716

771536
type: Reaction
kinetic law: 348899
product: 348887
reactant: 348875
reactant: 348863
fast: false
reversible: true

348899
type: KineticLaw
local parameters: 830403
local parameters: 830400
notes: k1*AMPAR_slash_A_B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx

830403
type: LocalParameter
units: 344978
value: 2.16E-15

830400
type: LocalParameter
units: 345062
value: 3.5998992E-16

348887
type: SpeciesReference
stoichiometry: 1.0
species: 764057

348875
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348863
type: SpeciesReference
stoichiometry: 1.0
species: 767296

775555
type: Reaction
kinetic law: 359343
product: 359331
product: 359319
reactant: 359307
fast: false
reversible: false

359343
type: KineticLaw
local parameters: 831370
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx

831370
type: LocalParameter
units: 344978
value: 3.06E-17

359331
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359319
type: SpeciesReference
stoichiometry: 1.0
species: 766296

359307
type: SpeciesReference
stoichiometry: 1.0
species: 767716

775595
type: Reaction
kinetic law: 359441
product: 359428
product: 359416
reactant: 359404
fast: false
reversible: false

359441
type: KineticLaw
local parameters: 831379
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx

831379
type: LocalParameter
units: 344978
value: 3.06E-17

359428
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359416
type: SpeciesReference
stoichiometry: 1.0
species: 766356

359404
type: SpeciesReference
stoichiometry: 1.0
species: 767736

767736
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

776975
type: Reaction
kinetic law: 362778
product: 362766
reactant: 362754
reactant: 362742
fast: false
reversible: true

362778
type: KineticLaw
local parameters: 831691
local parameters: 831688
notes: k1*CaMKII_minus_CaM_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx

831691
type: LocalParameter
units: 344978
value: 2.0E-17

831688
type: LocalParameter
units: 345062
value: 7.8126E-20

362766
type: SpeciesReference
stoichiometry: 1.0
species: 768476

362754
type: SpeciesReference
stoichiometry: 1.0
species: 769456

362742
type: SpeciesReference
stoichiometry: 1.0
species: 765756

770616
type: Reaction
kinetic law: 346786
product: 346774
reactant: 346762
notes: Diffusional equilibrium between PSD- and cytosolic compartment. According to D. Bary in Cell Movements 2nd ed 2001 D for proteins is 5e-7 cm^2/s giving 10 ms for a translocation of 1 um.
fast: false
reversible: true

346786
type: KineticLaw
local parameters: 830163
local parameters: 830160
notes: kf*CaM_minus_Ca4_minus_PSD-kb*CaM_minus_Ca4

830163
type: LocalParameter
units: 344978
value: 5.4E-15

830160
type: LocalParameter
units: 344978
value: 5.4E-15

346774
type: SpeciesReference
stoichiometry: 1.0
species: 763796

346762
type: SpeciesReference
stoichiometry: 1.0
species: 765936

775195
type: Reaction
kinetic law: 358448
product: 358436
product: 358424
reactant: 358412
fast: false
reversible: false

358448
type: KineticLaw
local parameters: 831289
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

831289
type: LocalParameter
units: 344978
value: 2.0E-18

358436
type: SpeciesReference
stoichiometry: 1.0
species: 766376

358424
type: SpeciesReference
stoichiometry: 1.0
species: 765796

358412
type: SpeciesReference
stoichiometry: 1.0
species: 767116

775315
type: Reaction
kinetic law: 358751
product: 358738
product: 358726
reactant: 358714
fast: false
reversible: false

358751
type: KineticLaw
local parameters: 831316
notes: k3*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx

831316
type: LocalParameter
units: 344978
value: 3.6E-16

358738
type: SpeciesReference
stoichiometry: 1.0
species: 767136

358726
type: SpeciesReference
stoichiometry: 1.0
species: 765496

765496
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

358714
type: SpeciesReference
stoichiometry: 1.0
species: 767196

767196
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.00703703703704E-5
initial amount: NaN
in compartment: 763757

768496
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

771056
type: Reaction
kinetic law: 347737
product: 347725
reactant: 347713
reactant: 347701
fast: false
reversible: true

347737
type: KineticLaw
local parameters: 830295
local parameters: 830292
notes: k1*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

830295
type: LocalParameter
units: 344978
value: 9.0E-16

830292
type: LocalParameter
units: 345062
value: 2.2062942E-16

347725
type: SpeciesReference
stoichiometry: 1.0
species: 763816

347713
type: SpeciesReference
stoichiometry: 1.0
species: 763797

347701
type: SpeciesReference
stoichiometry: 1.0
species: 764636

772316
type: Reaction
kinetic law: 350796
product: 350784
product: 350772
reactant: 350760
fast: false
reversible: false

350796
type: KineticLaw
local parameters: 830577
notes: k3*PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx

830577
type: LocalParameter
units: 344978
value: 5.4E-16

350784
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350772
type: SpeciesReference
stoichiometry: 1.0
species: 768616

350760
type: SpeciesReference
stoichiometry: 1.0
species: 764416

764416
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

772476
type: Reaction
kinetic law: 351187
product: 351175
product: 351163
reactant: 351151
fast: false
reversible: false

351187
type: KineticLaw
local parameters: 830613
notes: k3*PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx

830613
type: LocalParameter
units: 344978
value: 5.4E-16

351175
type: SpeciesReference
stoichiometry: 1.0
species: 763956

351163
type: SpeciesReference
stoichiometry: 1.0
species: 768676

351151
type: SpeciesReference
stoichiometry: 1.0
species: 764496

774396
type: Reaction
kinetic law: 356079
product: 356067
reactant: 356055
reactant: 356043
fast: false
reversible: true

356079
type: KineticLaw
local parameters: 831070
local parameters: 831067
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx

831070
type: LocalParameter
units: 344978
value: 1.4E-17

831067
type: LocalParameter
units: 345062
value: 8.7498E-18

356067
type: SpeciesReference
stoichiometry: 1.0
species: 766636

766636
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

356055
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356043
type: SpeciesReference
stoichiometry: 1.0
species: 768776

771916
type: Reaction
kinetic law: 349819
product: 349807
product: 349795
reactant: 349783
fast: false
reversible: false

349819
type: KineticLaw
local parameters: 830487
notes: k3*PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx

830487
type: LocalParameter
units: 344978
value: 5.4E-16

349807
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349795
type: SpeciesReference
stoichiometry: 1.0
species: 767416

349783
type: SpeciesReference
stoichiometry: 1.0
species: 764216

775215
type: Reaction
kinetic law: 358496
product: 358484
reactant: 358472
reactant: 358460
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

358496
type: KineticLaw
local parameters: 831295
local parameters: 831292
notes: k1*CaM_slash_neurogranin*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx

831295
type: LocalParameter
units: 344978
value: 2.106E-16

831292
type: LocalParameter
units: 345062
value: 9.180054E-18

358484
type: SpeciesReference
stoichiometry: 1.0
species: 767156

358472
type: SpeciesReference
stoichiometry: 1.0
species: 767136

358460
type: SpeciesReference
stoichiometry: 1.0
species: 764856

777015
type: Reaction
kinetic law: 362874
product: 362862
reactant: 362850
reactant: 362838
fast: false
reversible: true

362874
type: KineticLaw
local parameters: 831700
local parameters: 831697
notes: k1*CaMKII_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_act_autoph_slash_CaM_act_autoph_cplx

831700
type: LocalParameter
units: 344978
value: 8.0E-17

831697
type: LocalParameter
units: 345062
value: 3.12498E-19

362862
type: SpeciesReference
stoichiometry: 1.0
species: 768496

362850
type: SpeciesReference
stoichiometry: 1.0
species: 769456

362838
type: SpeciesReference
stoichiometry: 1.0
species: 765796

769116
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

776535
type: Reaction
kinetic law: 361714
product: 361702
reactant: 361689
reactant: 361677
fast: false
reversible: true

361714
type: KineticLaw
local parameters: 831592
local parameters: 831589
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx

831592
type: LocalParameter
units: 344978
value: 7.2E-16

831589
type: LocalParameter
units: 345062
value: 2.011824E-17

361702
type: SpeciesReference
stoichiometry: 1.0
species: 768216

361689
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361677
type: SpeciesReference
stoichiometry: 1.0
species: 768616

769976
type: Reaction
kinetic law: 345327
product: 345315
reactant: 345303
reactant: 345291
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true

345327
type: KineticLaw
local parameters: 829971
local parameters: 829968
notes: kf*CaM_slash_CaM*Ca^2-kb*CaM_minus_TR2_minus_Ca2

829971
type: LocalParameter
units: 344978
value: 6.48E-15

829968
type: LocalParameter
units: 345014
value: 6.47990604E-15

345315
type: SpeciesReference
stoichiometry: 1.0
species: 764976

345303
type: SpeciesReference
stoichiometry: 2.0
species: 763936

345291
type: SpeciesReference
stoichiometry: 1.0
species: 764796

764796
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 763757

764916
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 763776

776175
type: Reaction
kinetic law: 360843
product: 360831
reactant: 360819
reactant: 360807
fast: false
reversible: true

360843
type: KineticLaw
local parameters: 831511
local parameters: 831508
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx

831511
type: LocalParameter
units: 344978
value: 7.2E-16

831508
type: LocalParameter
units: 345062
value: 1.8106416E-16

360831
type: SpeciesReference
stoichiometry: 1.0
species: 768036

768036
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

360819
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360807
type: SpeciesReference
stoichiometry: 1.0
species: 767436

774975
type: Reaction
kinetic law: 357917
product: 357905
reactant: 357893
reactant: 357881
fast: false
reversible: true

357917
type: KineticLaw
local parameters: 831241
local parameters: 831238
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx

831241
type: LocalParameter
units: 344978
value: 1.4E-17

831238
type: LocalParameter
units: 345062
value: 8.7498E-18

357905
type: SpeciesReference
stoichiometry: 1.0
species: 767016

357893
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357881
type: SpeciesReference
stoichiometry: 1.0
species: 768576

774515
type: Reaction
kinetic law: 356617
product: 356605
product: 356593
reactant: 356581
fast: false
reversible: false

356617
type: KineticLaw
local parameters: 831118
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx

831118
type: LocalParameter
units: 344978
value: 1.7E-18

356605
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356593
type: SpeciesReference
stoichiometry: 1.0
species: 768676

356581
type: SpeciesReference
stoichiometry: 1.0
species: 766736

774016
type: Reaction
kinetic law: 354915
product: 354903
reactant: 354891
reactant: 354879
fast: false
reversible: true

354915
type: KineticLaw
local parameters: 830962
local parameters: 830959
notes: k1*CaMKII_minus_thr286_minus_CaM_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

830962
type: LocalParameter
units: 344978
value: 8.0E-18

830959
type: LocalParameter
units: 345062
value: 4.99998E-18

354903
type: SpeciesReference
stoichiometry: 1.0
species: 766396

354891
type: SpeciesReference
stoichiometry: 1.0
species: 766376

354879
type: SpeciesReference
stoichiometry: 1.0
species: 765736

766336
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

765336
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

770476
type: Reaction
kinetic law: 346472
product: 346460
reactant: 346448
reactant: 346436
fast: false
reversible: true

346472
type: KineticLaw
local parameters: 830121
local parameters: 830118
notes: kf*CaMKII_minus_PSD*CaM_minus_Ca4_minus_PSD-kb*CaMKII_minus_CaM_minus_PSD

830121
type: LocalParameter
units: 344978
value: 0.0

830118
type: LocalParameter
units: 345062
value: 4.99998E-16

346460
type: SpeciesReference
stoichiometry: 1.0
species: 765756

346448
type: SpeciesReference
stoichiometry: 1.0
species: 765936

346436
type: SpeciesReference
stoichiometry: 1.0
species: 765796

776195
type: Reaction
kinetic law: 360892
product: 360880
product: 360868
reactant: 360856
fast: false
reversible: false

360892
type: KineticLaw
local parameters: 831514
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx

831514
type: LocalParameter
units: 344978
value: 1.8E-16

360880
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360868
type: SpeciesReference
stoichiometry: 1.0
species: 767536

360856
type: SpeciesReference
stoichiometry: 1.0
species: 768036

774535
type: Reaction
kinetic law: 356665
product: 356653
reactant: 356641
reactant: 356629
fast: false
reversible: true

356665
type: KineticLaw
local parameters: 831124
local parameters: 831121
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx

831124
type: LocalParameter
units: 344978
value: 6.8E-18

831121
type: LocalParameter
units: 345062
value: 8.7498E-18

356653
type: SpeciesReference
stoichiometry: 1.0
species: 766756

766756
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

356641
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356629
type: SpeciesReference
stoichiometry: 1.0
species: 768736

770116
type: Reaction
kinetic law: 345654
product: 345642
reactant: 345630
reactant: 345618
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true

345654
type: KineticLaw
local parameters: 830013
local parameters: 830010
notes: kf*CaM_slash_neurogranin_PSD*CaM_slash_CaM_minus_PSD-kb*CaM_slash_neurogranin_minus_CaM_PSD

830013
type: LocalParameter
units: 344978
value: 1.0E-17

830010
type: LocalParameter
units: 345062
value: 3.0E-18

345642
type: SpeciesReference
stoichiometry: 1.0
species: 764896

764896
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

345630
type: SpeciesReference
stoichiometry: 1.0
species: 764876

764876
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 763776

345618
type: SpeciesReference
stoichiometry: 1.0
species: 764916

769356
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

775795
type: Reaction
kinetic law: 359925
product: 359913
product: 359901
reactant: 359889
fast: false
reversible: false

359925
type: KineticLaw
local parameters: 831424
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx

831424
type: LocalParameter
units: 344978
value: 1.8E-16

359913
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359901
type: SpeciesReference
stoichiometry: 1.0
species: 767296

359889
type: SpeciesReference
stoichiometry: 1.0
species: 767836

774875
type: Reaction
kinetic law: 357675
product: 357663
product: 357651
reactant: 357639
fast: false
reversible: false

357675
type: KineticLaw
local parameters: 831217
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx

831217
type: LocalParameter
units: 344978
value: 3.5E-18

357663
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357651
type: SpeciesReference
stoichiometry: 1.0
species: 768796

357639
type: SpeciesReference
stoichiometry: 1.0
species: 766956

772876
type: Reaction
kinetic law: 352160
product: 352148
product: 352136
reactant: 352124
fast: false
reversible: false

352160
type: KineticLaw
local parameters: 830703
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx

830703
type: LocalParameter
units: 344978
value: 1.8E-16

352148
type: SpeciesReference
stoichiometry: 1.0
species: 765076

352136
type: SpeciesReference
stoichiometry: 1.0
species: 765056

352124
type: SpeciesReference
stoichiometry: 1.0
species: 765116

775615
type: Reaction
kinetic law: 359490
product: 359478
reactant: 359466
reactant: 359454
fast: false
reversible: true

359490
type: KineticLaw
local parameters: 831385
local parameters: 831382
notes: k1*AMPAR_slash_A845_star__B*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx

831385
type: LocalParameter
units: 344978
value: 7.2E-16

831382
type: LocalParameter
units: 345062
value: 1.8106416E-16

359478
type: SpeciesReference
stoichiometry: 1.0
species: 767756

359466
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359454
type: SpeciesReference
stoichiometry: 1.0
species: 767336

776255
type: Reaction
kinetic law: 361037
product: 361025
reactant: 361013
reactant: 361001
fast: false
reversible: true

361037
type: KineticLaw
local parameters: 831529
local parameters: 831526
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx

831529
type: LocalParameter
units: 344978
value: 7.2E-16

831526
type: LocalParameter
units: 345062
value: 2.011824E-17

361025
type: SpeciesReference
stoichiometry: 1.0
species: 768076

361013
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361001
type: SpeciesReference
stoichiometry: 1.0
species: 768696

765436
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

766976
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

769176
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 22.0
initial amount: NaN
in compartment: 763757

775355
type: Reaction
kinetic law: 358849
product: 358837
product: 358825
reactant: 358812
fast: false
reversible: false

358849
type: KineticLaw
local parameters: 831325
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx

831325
type: LocalParameter
units: 344978
value: 5.22E-17

358837
type: SpeciesReference
stoichiometry: 1.0
species: 767136

358825
type: SpeciesReference
stoichiometry: 1.0
species: 764936

358812
type: SpeciesReference
stoichiometry: 1.0
species: 767216

767216
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

776735
type: Reaction
kinetic law: 362198
product: 362186
reactant: 362173
reactant: 362161
fast: false
reversible: true

362198
type: KineticLaw
local parameters: 831637
local parameters: 831634
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx

831637
type: LocalParameter
units: 344978
value: 7.2E-16

831634
type: LocalParameter
units: 345062
value: 2.011824E-17

362186
type: SpeciesReference
stoichiometry: 1.0
species: 768316

362173
type: SpeciesReference
stoichiometry: 1.0
species: 767636

362161
type: SpeciesReference
stoichiometry: 1.0
species: 768816

773676
type: Reaction
kinetic law: 354094
product: 354082
product: 354070
reactant: 354058
fast: false
reversible: false

354094
type: KineticLaw
local parameters: 830886
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx

830886
type: LocalParameter
units: 344978
value: 5.0E-18

354082
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354070
type: SpeciesReference
stoichiometry: 1.0
species: 768556

354058
type: SpeciesReference
stoichiometry: 1.0
species: 766116

766116
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 763776

774416
type: Reaction
kinetic law: 356175
product: 356163
reactant: 356151
reactant: 356139
fast: false
reversible: true

356175
type: KineticLaw
local parameters: 831079
local parameters: 831076
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx

831079
type: LocalParameter
units: 344978
value: 1.4E-17

831076
type: LocalParameter
units: 345062
value: 8.7498E-18

356163
type: SpeciesReference
stoichiometry: 1.0
species: 766656

356151
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356139
type: SpeciesReference
stoichiometry: 1.0
species: 768716

771276
type: Reaction
kinetic law: 348271
product: 348259
product: 348247
reactant: 348235
fast: false
reversible: false

348271
type: KineticLaw
local parameters: 830343
notes: k3*PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx

830343
type: LocalParameter
units: 344978
value: 8.1E-16

348259
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348247
type: SpeciesReference
stoichiometry: 1.0
species: 765596

348235
type: SpeciesReference
stoichiometry: 1.0
species: 763976

776775
type: Reaction
kinetic law: 362295
product: 362283
reactant: 362271
reactant: 362259
fast: false
reversible: true

362295
type: KineticLaw
local parameters: 831646
local parameters: 831643
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx

831646
type: LocalParameter
units: 344978
value: 7.2E-16

831643
type: LocalParameter
units: 345062
value: 2.011824E-17

362283
type: SpeciesReference
stoichiometry: 1.0
species: 768336

362271
type: SpeciesReference
stoichiometry: 1.0
species: 767636

362259
type: SpeciesReference
stoichiometry: 1.0
species: 768816

776275
type: Reaction
kinetic law: 361085
product: 361073
product: 361061
reactant: 361049
fast: false
reversible: false

361085
type: KineticLaw
local parameters: 831532
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx

831532
type: LocalParameter
units: 344978
value: 1.8E-16

361073
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361061
type: SpeciesReference
stoichiometry: 1.0
species: 768656

361049
type: SpeciesReference
stoichiometry: 1.0
species: 768076

768256
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

768296
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

776575
type: Reaction
kinetic law: 361810
product: 361798
reactant: 361786
reactant: 361774
fast: false
reversible: true

361810
type: KineticLaw
local parameters: 831601
local parameters: 831598
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx

831601
type: LocalParameter
units: 344978
value: 7.2E-16

831598
type: LocalParameter
units: 345062
value: 2.011824E-17

361798
type: SpeciesReference
stoichiometry: 1.0
species: 768236

361786
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361774
type: SpeciesReference
stoichiometry: 1.0
species: 768796

774156
type: Reaction
kinetic law: 355254
product: 355242
product: 355230
reactant: 355218
fast: false
reversible: false

355254
type: KineticLaw
local parameters: 830992
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

830992
type: LocalParameter
units: 344978
value: 2.0E-18

355242
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355230
type: SpeciesReference
stoichiometry: 1.0
species: 768836

355218
type: SpeciesReference
stoichiometry: 1.0
species: 766456

766456
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

776875
type: Reaction
kinetic law: 362537
product: 362525
product: 362513
reactant: 362501
fast: false
reversible: false

362537
type: KineticLaw
local parameters: 831667
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx

831667
type: LocalParameter
units: 344978
value: 1.8E-16

362525
type: SpeciesReference
stoichiometry: 1.0
species: 767636

362513
type: SpeciesReference
stoichiometry: 1.0
species: 768576

362501
type: SpeciesReference
stoichiometry: 1.0
species: 768376

773356
type: Reaction
kinetic law: 353325
product: 353313
product: 353301
reactant: 353289
fast: false
reversible: false

353325
type: KineticLaw
local parameters: 830814
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_autoph_slash_auton_minus_autoph_cplx

830814
type: LocalParameter
units: 344978
value: 2.0E-17

353313
type: SpeciesReference
stoichiometry: 1.0
species: 769096

353301
type: SpeciesReference
stoichiometry: 1.0
species: 765776

353289
type: SpeciesReference
stoichiometry: 1.0
species: 765876

771936
type: Reaction
kinetic law: 349867
product: 349855
reactant: 349843
reactant: 349831
fast: false
reversible: true

349867
type: KineticLaw
local parameters: 830493
local parameters: 830490
notes: k1*AMPAR_slash_A845_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx

830493
type: LocalParameter
units: 344978
value: 2.16E-15

830490
type: LocalParameter
units: 345062
value: 3.5998992E-16

349855
type: SpeciesReference
stoichiometry: 1.0
species: 764236

764236
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

349843
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349831
type: SpeciesReference
stoichiometry: 1.0
species: 767536

774056
type: Reaction
kinetic law: 355012
product: 354999
reactant: 354987
reactant: 354975
fast: false
reversible: true

355012
type: KineticLaw
local parameters: 830971
local parameters: 830968
notes: k1*CaMKII_minus_thr286_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

830971
type: LocalParameter
units: 344978
value: 8.0E-18

830968
type: LocalParameter
units: 345062
value: 4.99998E-18

354999
type: SpeciesReference
stoichiometry: 1.0
species: 766416

766416
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

354987
type: SpeciesReference
stoichiometry: 1.0
species: 766376

354975
type: SpeciesReference
stoichiometry: 1.0
species: 765776

773576
type: Reaction
kinetic law: 353854
product: 353842
reactant: 353830
reactant: 353818
fast: false
reversible: true

353854
type: KineticLaw
local parameters: 830865
local parameters: 830862
notes: k1*AMPAR_memb_slash_A_B845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx

830865
type: LocalParameter
units: 344978
value: 2.0E-17

830862
type: LocalParameter
units: 345062
value: 2.77776E-19

353842
type: SpeciesReference
stoichiometry: 1.0
species: 766076

353830
type: SpeciesReference
stoichiometry: 1.0
species: 769136

353818
type: SpeciesReference
stoichiometry: 1.0
species: 768656

774855
type: Reaction
kinetic law: 357626
product: 357614
reactant: 357602
reactant: 357590
fast: false
reversible: true

357626
type: KineticLaw
local parameters: 831214
local parameters: 831211
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx

831214
type: LocalParameter
units: 344978
value: 1.4E-17

831211
type: LocalParameter
units: 345062
value: 8.7498E-18

357614
type: SpeciesReference
stoichiometry: 1.0
species: 766956

357602
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357590
type: SpeciesReference
stoichiometry: 1.0
species: 768816

775015
type: Reaction
kinetic law: 358014
product: 358002
reactant: 357990
reactant: 357978
fast: false
reversible: true

358014
type: KineticLaw
local parameters: 831250
local parameters: 831247
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx

831250
type: LocalParameter
units: 344978
value: 1.4E-17

831247
type: LocalParameter
units: 345062
value: 8.7498E-18

358002
type: SpeciesReference
stoichiometry: 1.0
species: 767036

357990
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357978
type: SpeciesReference
stoichiometry: 1.0
species: 768816

770276
type: Reaction
kinetic law: 346027
product: 346015
reactant: 346003
reactant: 345991
fast: false
reversible: true

346027
type: KineticLaw
local parameters: 830061
local parameters: 830058
notes: kf*PKA_slash_R2C2_minus_cAMP2*cAMP-kb*PKA_slash_R2C2_minus_cAMP3

830061
type: LocalParameter
units: 344978
value: 9.9E-15

830058
type: LocalParameter
units: 345062
value: 6.750054E-15

346015
type: SpeciesReference
stoichiometry: 1.0
species: 765336

346003
type: SpeciesReference
stoichiometry: 1.0
species: 763916

345991
type: SpeciesReference
stoichiometry: 1.0
species: 765316

773196
type: Reaction
kinetic law: 352938
product: 352926
product: 352914
reactant: 352902
fast: false
reversible: false

352938
type: KineticLaw
local parameters: 830778
notes: k3*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx

830778
type: LocalParameter
units: 344978
value: 1.5003E-16

352926
type: SpeciesReference
stoichiometry: 1.0
species: 765636

352914
type: SpeciesReference
stoichiometry: 1.0
species: 765536

352902
type: SpeciesReference
stoichiometry: 1.0
species: 765656

774615
type: Reaction
kinetic law: 356905
product: 356893
product: 356881
reactant: 356869
fast: false
reversible: false

356905
type: KineticLaw
local parameters: 831145
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx

831145
type: LocalParameter
units: 344978
value: 1.7E-18

356893
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356881
type: SpeciesReference
stoichiometry: 1.0
species: 768756

356869
type: SpeciesReference
stoichiometry: 1.0
species: 766796

766796
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

775235
type: Reaction
kinetic law: 358544
product: 358532
product: 358520
reactant: 358508
fast: false
reversible: false

358544
type: KineticLaw
local parameters: 831298
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx

831298
type: LocalParameter
units: 344978
value: 5.22E-17

358532
type: SpeciesReference
stoichiometry: 1.0
species: 767136

358520
type: SpeciesReference
stoichiometry: 1.0
species: 764836

358508
type: SpeciesReference
stoichiometry: 1.0
species: 767156

775935
type: Reaction
kinetic law: 360264
product: 360252
reactant: 360240
reactant: 360228
fast: false
reversible: true

360264
type: KineticLaw
local parameters: 831457
local parameters: 831454
notes: k1*AMPAR_slash_A845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx

831457
type: LocalParameter
units: 344978
value: 7.2E-16

831454
type: LocalParameter
units: 345062
value: 1.8106416E-16

360252
type: SpeciesReference
stoichiometry: 1.0
species: 767916

767916
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

360240
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360228
type: SpeciesReference
stoichiometry: 1.0
species: 767396

773656
type: Reaction
kinetic law: 354046
product: 354034
reactant: 354022
reactant: 354010
fast: false
reversible: true

354046
type: KineticLaw
local parameters: 830883
local parameters: 830880
notes: k1*AMPAR_memb_slash_A_B*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx

830883
type: LocalParameter
units: 344978
value: 2.0E-17

830880
type: LocalParameter
units: 345062
value: 2.77776E-19

354034
type: SpeciesReference
stoichiometry: 1.0
species: 766116

354022
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354010
type: SpeciesReference
stoichiometry: 1.0
species: 768516

771676
type: Reaction
kinetic law: 349238
product: 349226
product: 349214
reactant: 349201
fast: false
reversible: false

349238
type: KineticLaw
local parameters: 830433
notes: k3*PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx

830433
type: LocalParameter
units: 344978
value: 5.4E-16

349226
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349214
type: SpeciesReference
stoichiometry: 1.0
species: 767496

349201
type: SpeciesReference
stoichiometry: 1.0
species: 764116

764116
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

774415
type: Reaction
kinetic law: 356127
product: 356115
product: 356103
reactant: 356091
fast: false
reversible: false

356127
type: KineticLaw
local parameters: 831073
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx

831073
type: LocalParameter
units: 344978
value: 3.5E-18

356115
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356103
type: SpeciesReference
stoichiometry: 1.0
species: 768696

356091
type: SpeciesReference
stoichiometry: 1.0
species: 766636

774356
type: Reaction
kinetic law: 355886
product: 355874
reactant: 355862
reactant: 355850
fast: false
reversible: true

355886
type: KineticLaw
local parameters: 831052
local parameters: 831049
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx

831052
type: LocalParameter
units: 344978
value: 6.8E-18

831049
type: LocalParameter
units: 345062
value: 8.7498E-18

355874
type: SpeciesReference
stoichiometry: 1.0
species: 766596

766596
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

355862
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355850
type: SpeciesReference
stoichiometry: 1.0
species: 768716

772936
type: Reaction
kinetic law: 352305
product: 352293
reactant: 352281
reactant: 352269
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true

352305
type: KineticLaw
local parameters: 830718
local parameters: 830715
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx

830718
type: LocalParameter
units: 344978
value: 7.50006E-16

830715
type: LocalParameter
units: 345062
value: 6.4584E-18

352293
type: SpeciesReference
stoichiometry: 1.0
species: 765156

352281
type: SpeciesReference
stoichiometry: 1.0
species: 765076

352269
type: SpeciesReference
stoichiometry: 1.0
species: 766336

772376
type: Reaction
kinetic law: 350943
product: 350931
reactant: 350919
reactant: 350907
fast: false
reversible: true

350943
type: KineticLaw
local parameters: 830592
local parameters: 830589
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx

830592
type: LocalParameter
units: 344978
value: 2.16E-15

830589
type: LocalParameter
units: 345062
value: 3.999888E-17

350931
type: SpeciesReference
stoichiometry: 1.0
species: 764456

764456
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

350919
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350907
type: SpeciesReference
stoichiometry: 1.0
species: 768676

771876
type: Reaction
kinetic law: 349722
product: 349709
product: 349697
reactant: 349684
fast: false
reversible: false

349722
type: KineticLaw
local parameters: 830478
notes: k3*PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx

830478
type: LocalParameter
units: 344978
value: 5.4E-16

349709
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349697
type: SpeciesReference
stoichiometry: 1.0
species: 767396

349684
type: SpeciesReference
stoichiometry: 1.0
species: 764196

775835
type: Reaction
kinetic law: 360021
product: 360009
product: 359997
reactant: 359985
fast: false
reversible: false

360021
type: KineticLaw
local parameters: 831433
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx

831433
type: LocalParameter
units: 344978
value: 1.8E-16

360009
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359997
type: SpeciesReference
stoichiometry: 1.0
species: 767316

359985
type: SpeciesReference
stoichiometry: 1.0
species: 767856

773416
type: Reaction
kinetic law: 353470
product: 353457
reactant: 353445
reactant: 353433
fast: false
reversible: true

353470
type: KineticLaw
local parameters: 830829
local parameters: 830826
notes: k1*AMPAR_memb_slash_A_B845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx

830829
type: LocalParameter
units: 344978
value: 2.0E-17

830826
type: LocalParameter
units: 345062
value: 2.77776E-19

353457
type: SpeciesReference
stoichiometry: 1.0
species: 765996

353445
type: SpeciesReference
stoichiometry: 1.0
species: 769136

353433
type: SpeciesReference
stoichiometry: 1.0
species: 768656

769376
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

776015
type: Reaction
kinetic law: 360456
product: 360444
reactant: 360432
reactant: 360420
fast: false
reversible: true

360456
type: KineticLaw
local parameters: 831475
local parameters: 831472
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx

831475
type: LocalParameter
units: 344978
value: 7.2E-16

831472
type: LocalParameter
units: 345062
value: 1.8106416E-16

360444
type: SpeciesReference
stoichiometry: 1.0
species: 767956

360432
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360420
type: SpeciesReference
stoichiometry: 1.0
species: 767436

770356
type: Reaction
kinetic law: 346219
product: 346207
reactant: 346195
reactant: 346183
notes: This has to be set to zero for matching the expts in vitro. In vivo we need to consider the inhibition though. kf = 1e-5 kb = 1
fast: false
reversible: true

346219
type: KineticLaw
local parameters: 830085
local parameters: 830082
notes: kf*PKA_minus_active*PKA_slash_PKA_minus_inhibitor-kb*PKA_slash_inhibited_minus_PKA

830085
type: LocalParameter
units: 344978
value: 9.0E-17

830082
type: LocalParameter
units: 345062
value: 5.399946E-15

346207
type: SpeciesReference
stoichiometry: 1.0
species: 765436

346195
type: SpeciesReference
stoichiometry: 1.0
species: 765416

765416
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.259259259259259
initial amount: NaN
in compartment: 763757

346183
type: SpeciesReference
stoichiometry: 1.0
species: 763956

775535
type: Reaction
kinetic law: 359295
product: 359283
reactant: 359271
reactant: 359259
fast: false
reversible: true

359295
type: KineticLaw
local parameters: 831367
local parameters: 831364
notes: k1*PP1_PSD_slash_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx

831367
type: LocalParameter
units: 344978
value: 1.224E-16

831364
type: LocalParameter
units: 345062
value: 3.420036E-18

359283
type: SpeciesReference
stoichiometry: 1.0
species: 767716

359271
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359259
type: SpeciesReference
stoichiometry: 1.0
species: 766316

774915
type: Reaction
kinetic law: 357772
product: 357760
product: 357748
reactant: 357736
fast: false
reversible: false

357772
type: KineticLaw
local parameters: 831226
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx

831226
type: LocalParameter
units: 344978
value: 3.5E-18

357760
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357748
type: SpeciesReference
stoichiometry: 1.0
species: 768736

357736
type: SpeciesReference
stoichiometry: 1.0
species: 766976

773216
type: Reaction
kinetic law: 352986
product: 352974
reactant: 352962
reactant: 352950
notes: Max activity ~10umol/min/mg in presence of lots of CaM. Affinity is low, 40 uM. k3 = 10, k2 = 40, k1 = (50/40) / 6e5.
fast: false
reversible: true

352986
type: KineticLaw
local parameters: 830784
local parameters: 830781
notes: k1*cAMP*AC_slash_CaM_dot_PDE1-k2*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx

830784
type: LocalParameter
units: 344978
value: 3.6E-15

830781
type: LocalParameter
units: 345062
value: 1.1339838E-16

352974
type: SpeciesReference
stoichiometry: 1.0
species: 765696

352962
type: SpeciesReference
stoichiometry: 1.0
species: 765676

352950
type: SpeciesReference
stoichiometry: 1.0
species: 763916

771096
type: Reaction
kinetic law: 347833
product: 347821
reactant: 347809
reactant: 347797
fast: false
reversible: true

347833
type: KineticLaw
local parameters: 830304
local parameters: 830301
notes: k1*CaMKII_slash_CaMKII_minus_thr286*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

830304
type: LocalParameter
units: 344978
value: 9.0E-16

830301
type: LocalParameter
units: 345062
value: 2.2062942E-16

347821
type: SpeciesReference
stoichiometry: 1.0
species: 763836

347809
type: SpeciesReference
stoichiometry: 1.0
species: 763797

347797
type: SpeciesReference
stoichiometry: 1.0
species: 764676

765976
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 763776

765516
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 763757

775575
type: Reaction
kinetic law: 359392
product: 359379
reactant: 359367
reactant: 359355
fast: false
reversible: true

359392
type: KineticLaw
local parameters: 831376
local parameters: 831373
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx

831376
type: LocalParameter
units: 344978
value: 1.224E-16

831373
type: LocalParameter
units: 345062
value: 3.420036E-18

359379
type: SpeciesReference
stoichiometry: 1.0
species: 767736

359367
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359355
type: SpeciesReference
stoichiometry: 1.0
species: 766336

775855
type: Reaction
kinetic law: 360071
product: 360058
reactant: 360045
reactant: 360033
fast: false
reversible: true

360071
type: KineticLaw
local parameters: 831439
local parameters: 831436
notes: k1*AMPAR_slash_A_B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx

831439
type: LocalParameter
units: 344978
value: 7.2E-16

831436
type: LocalParameter
units: 345062
value: 1.8106416E-16

360058
type: SpeciesReference
stoichiometry: 1.0
species: 767876

360045
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360033
type: SpeciesReference
stoichiometry: 1.0
species: 767476

774636
type: Reaction
kinetic law: 357049
product: 357037
reactant: 357025
reactant: 357013
fast: false
reversible: true

357049
type: KineticLaw
local parameters: 831160
local parameters: 831157
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx

831160
type: LocalParameter
units: 344978
value: 6.8E-18

831157
type: LocalParameter
units: 345062
value: 8.7498E-18

357037
type: SpeciesReference
stoichiometry: 1.0
species: 766836

766836
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

357025
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357013
type: SpeciesReference
stoichiometry: 1.0
species: 768756

776615
type: Reaction
kinetic law: 361906
product: 361894
reactant: 361882
reactant: 361870
fast: false
reversible: true

361906
type: KineticLaw
local parameters: 831610
local parameters: 831607
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx

831610
type: LocalParameter
units: 344978
value: 7.2E-16

831607
type: LocalParameter
units: 345062
value: 2.011824E-17

361894
type: SpeciesReference
stoichiometry: 1.0
species: 768256

361882
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361870
type: SpeciesReference
stoichiometry: 1.0
species: 768796

769196
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

770856
type: Reaction
kinetic law: 347303
product: 347291
reactant: 347279
fast: false
reversible: true

347303
type: KineticLaw
local parameters: 830235
local parameters: 830232
notes: kf*AMPAR_slash_A845_star__B845_star_-kb*AMPAR_slash_AMPAR_deg

830235
type: LocalParameter
units: 344978
value: 0.0

830232
type: LocalParameter
units: 344978
value: 3.24E-21

347291
type: SpeciesReference
stoichiometry: 1.0
species: 768896

347279
type: SpeciesReference
stoichiometry: 1.0
species: 767396

771036
type: Reaction
kinetic law: 347689
product: 347677
reactant: 347664
notes: Represents both synthesis and degradation of the receptor. The rate is set to be rather fast for now. The forward rate also includes scaling terms because the AMPAR_bulk is in the dendritic volume of 5e-18. This means that we need to lower Kf to account for the difference in volumes. Effectively Kf is 1/sec, but the scaled version becomes 9e-20/5e-18 = 0.018
fast: false
reversible: true

347689
type: KineticLaw
local parameters: 830289
local parameters: 830286
notes: kf*AMPAR_bulk-kb*AMPAR_slash_A_B

830289
type: LocalParameter
units: 344978
value: 9.0E-17

830286
type: LocalParameter
units: 344978
value: 9.0E-17

347677
type: SpeciesReference
stoichiometry: 1.0
species: 767296

347664
type: SpeciesReference
stoichiometry: 1.0
species: 769016

769156
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 763776

769216
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

768936
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 763757

771796
type: Reaction
kinetic law: 349527
product: 349515
product: 349503
reactant: 349490
fast: false
reversible: false

349527
type: KineticLaw
local parameters: 830460
notes: k3*PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx

830460
type: LocalParameter
units: 344978
value: 5.4E-16

349515
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349503
type: SpeciesReference
stoichiometry: 1.0
species: 767436

349490
type: SpeciesReference
stoichiometry: 1.0
species: 764176

774376
type: Reaction
kinetic law: 355983
product: 355971
reactant: 355959
reactant: 355947
fast: false
reversible: true

355983
type: KineticLaw
local parameters: 831061
local parameters: 831058
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx

831061
type: LocalParameter
units: 344978
value: 6.8E-18

831058
type: LocalParameter
units: 345062
value: 8.7498E-18

355971
type: SpeciesReference
stoichiometry: 1.0
species: 766616

355959
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355947
type: SpeciesReference
stoichiometry: 1.0
species: 768616

776515
type: Reaction
kinetic law: 361665
product: 361653
product: 361641
reactant: 361629
fast: false
reversible: false

361665
type: KineticLaw
local parameters: 831586
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx

831586
type: LocalParameter
units: 344978
value: 1.8E-16

361653
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361641
type: SpeciesReference
stoichiometry: 1.0
species: 768536

361629
type: SpeciesReference
stoichiometry: 1.0
species: 768196

768276
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

772036
type: Reaction
kinetic law: 350108
product: 350096
product: 350084
reactant: 350072
fast: false
reversible: false

350108
type: KineticLaw
local parameters: 830514
notes: k3*PKA_minus_active_slash_PKA_slash_PKA_cplx

830514
type: LocalParameter
units: 344978
value: 5.4E-16

350096
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350084
type: SpeciesReference
stoichiometry: 1.0
species: 768696

350072
type: SpeciesReference
stoichiometry: 1.0
species: 764276

764276
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

775915
type: Reaction
kinetic law: 360215
product: 360203
product: 360191
reactant: 360179
fast: false
reversible: false

360215
type: KineticLaw
local parameters: 831451
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx

831451
type: LocalParameter
units: 344978
value: 1.8E-16

360203
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360191
type: SpeciesReference
stoichiometry: 1.0
species: 767556

360179
type: SpeciesReference
stoichiometry: 1.0
species: 767896

770876
type: Reaction
kinetic law: 347351
product: 347339
reactant: 347327
reactant: 347315
fast: false
reversible: true

347351
type: KineticLaw
local parameters: 830241
local parameters: 830238
notes: kf*AMPAR_slash_A835_star_845_star__B835_star_845_star_*Anchor-kb*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_

830241
type: LocalParameter
units: 344978
value: 8.0E-20

830238
type: LocalParameter
units: 345062
value: 1.08E-19

347339
type: SpeciesReference
stoichiometry: 1.0
species: 768816

347327
type: SpeciesReference
stoichiometry: 1.0
species: 768436

347315
type: SpeciesReference
stoichiometry: 1.0
species: 767456

772256
type: Reaction
kinetic law: 350651
product: 350639
reactant: 350627
reactant: 350615
fast: false
reversible: true

350651
type: KineticLaw
local parameters: 830565
local parameters: 830562
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx

830565
type: LocalParameter
units: 344978
value: 2.16E-15

830562
type: LocalParameter
units: 345062
value: 3.999888E-17

350639
type: SpeciesReference
stoichiometry: 1.0
species: 764396

350627
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350615
type: SpeciesReference
stoichiometry: 1.0
species: 768536

776635
type: Reaction
kinetic law: 361955
product: 361942
product: 361930
reactant: 361918
fast: false
reversible: false

361955
type: KineticLaw
local parameters: 831613
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx

831613
type: LocalParameter
units: 344978
value: 1.8E-16

361942
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361930
type: SpeciesReference
stoichiometry: 1.0
species: 768676

361918
type: SpeciesReference
stoichiometry: 1.0
species: 768256

770416
type: Reaction
kinetic law: 346339
product: 346327
reactant: 346315
notes: The rates for this are poorly constrained. In adipocytes (probably a different PDE) the dephosphorylation is complete within 15 min, but there are no intermediate time points so it could be much faster. Identity of phosphatase etc is still unknown.
fast: false
reversible: true

346339
type: KineticLaw
local parameters: 830103
local parameters: 830100
notes: kf*AC_slash_cAMP_minus_PDE_star_-kb*AC_slash_cAMP_minus_PDE

830103
type: LocalParameter
units: 344978
value: 0.0

830100
type: LocalParameter
units: 344978
value: 9.0E-19

346327
type: SpeciesReference
stoichiometry: 1.0
species: 765556

346315
type: SpeciesReference
stoichiometry: 1.0
species: 765596

770016
type: Reaction
kinetic law: 345424
product: 345412
reactant: 345400
reactant: 345388
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true

345424
type: KineticLaw
local parameters: 829983
local parameters: 829980
notes: kf*CaM_slash_neurogranin*CaM_slash_CaM-kb*CaM_slash_neurogranin_minus_CaM

829983
type: LocalParameter
units: 344978
value: 9.0E-17

829980
type: LocalParameter
units: 345062
value: 2.7000216E-17

345412
type: SpeciesReference
stoichiometry: 1.0
species: 764816

345400
type: SpeciesReference
stoichiometry: 1.0
species: 764796

345388
type: SpeciesReference
stoichiometry: 1.0
species: 764856

773336
type: Reaction
kinetic law: 353276
product: 353264
reactant: 353252
reactant: 353240
fast: false
reversible: true

353276
type: KineticLaw
local parameters: 830811
local parameters: 830808
notes: k1*CaMKII_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_autoph_slash_auton_minus_autoph_cplx

830811
type: LocalParameter
units: 344978
value: 8.0E-17

830808
type: LocalParameter
units: 345062
value: 1.99998E-19

353264
type: SpeciesReference
stoichiometry: 1.0
species: 765876

353252
type: SpeciesReference
stoichiometry: 1.0
species: 769096

353240
type: SpeciesReference
stoichiometry: 1.0
species: 765796

774575
type: Reaction
kinetic law: 356761
product: 356749
reactant: 356737
reactant: 356725
fast: false
reversible: true

356761
type: KineticLaw
local parameters: 831133
local parameters: 831130
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx

831133
type: LocalParameter
units: 344978
value: 6.8E-18

831130
type: LocalParameter
units: 345062
value: 8.7498E-18

356749
type: SpeciesReference
stoichiometry: 1.0
species: 766776

356737
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356725
type: SpeciesReference
stoichiometry: 1.0
species: 768676

774076
type: Reaction
kinetic law: 355060
product: 355048
product: 355036
reactant: 355024
fast: false
reversible: false

355060
type: KineticLaw
local parameters: 830974
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

830974
type: LocalParameter
units: 344978
value: 2.0E-18

355048
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355036
type: SpeciesReference
stoichiometry: 1.0
species: 765796

355024
type: SpeciesReference
stoichiometry: 1.0
species: 766416

773036
type: Reaction
kinetic law: 352547
product: 352535
product: 352523
reactant: 352511
fast: false
reversible: false

352547
type: KineticLaw
local parameters: 830739
notes: k3*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx

830739
type: LocalParameter
units: 344978
value: 3.06E-18

352535
type: SpeciesReference
stoichiometry: 1.0
species: 765176

352523
type: SpeciesReference
stoichiometry: 1.0
species: 766296

352511
type: SpeciesReference
stoichiometry: 1.0
species: 765216

774296
type: Reaction
kinetic law: 355646
product: 355633
product: 355620
reactant: 355608
fast: false
reversible: false

355646
type: KineticLaw
local parameters: 831028
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx

831028
type: LocalParameter
units: 344978
value: 1.7E-18

355633
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355620
type: SpeciesReference
stoichiometry: 1.0
species: 768516

355608
type: SpeciesReference
stoichiometry: 1.0
species: 766536

770036
type: Reaction
kinetic law: 345460
product: 345448
reactant: 345436
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true

345460
type: KineticLaw
local parameters: 829989
local parameters: 829986
notes: kf*CaM_slash_neurogranin_star_-kb*CaM_slash_neurogranin

829989
type: LocalParameter
units: 344978
value: 0.0

829986
type: LocalParameter
units: 344978
value: 4.5E-19

345448
type: SpeciesReference
stoichiometry: 1.0
species: 764856

345436
type: SpeciesReference
stoichiometry: 1.0
species: 764836

773816
type: Reaction
kinetic law: 354430
product: 354418
reactant: 354406
reactant: 354394
fast: false
reversible: true

354430
type: KineticLaw
local parameters: 830919
local parameters: 830916
notes: k1*AMPAR_memb_slash_A_B831_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx

830919
type: LocalParameter
units: 344978
value: 2.0E-17

830916
type: LocalParameter
units: 345062
value: 2.77776E-19

354418
type: SpeciesReference
stoichiometry: 1.0
species: 766196

354406
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354394
type: SpeciesReference
stoichiometry: 1.0
species: 768556

773076
type: Reaction
kinetic law: 352646
modifier: 352634
product: 352621
reactant: 352609
notes: Reduced Km to match expt data for basal activation of AC2 by PKC. Now k1 = 2.9e-6, k2 = 72, k3 = 18 18 Feb: Raised Km to 300 based on BRENDA data. Unlikely to make much difference, given the vast amount of ATP.
fast: false
reversible: false

352646
type: KineticLaw
local parameters: 830751
local parameters: 830748
notes: kcat*AC_slash_AC2_star_*AC_slash_ATP/(Km+AC_slash_ATP)

830751
type: LocalParameter
units: 344942
value: 300.001920012288

830748
type: LocalParameter
units: 344978
value: 1.8E-16

352621
type: SpeciesReference
stoichiometry: 1.0
species: 763916

352609
type: SpeciesReference
stoichiometry: 1.0
species: 768856

772596
type: Reaction
kinetic law: 351481
product: 351468
product: 351455
reactant: 351443
fast: false
reversible: false

351481
type: KineticLaw
local parameters: 830640
notes: k3*PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx

830640
type: LocalParameter
units: 344978
value: 5.4E-16

351468
type: SpeciesReference
stoichiometry: 1.0
species: 763956

351455
type: SpeciesReference
stoichiometry: 1.0
species: 768756

351443
type: SpeciesReference
stoichiometry: 1.0
species: 764556

771416
type: Reaction
kinetic law: 348610
product: 348598
reactant: 348586
reactant: 348574
fast: false
reversible: true

348610
type: KineticLaw
local parameters: 830376
local parameters: 830373
notes: k1*AMPAR_slash_A831_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx

830376
type: LocalParameter
units: 344978
value: 2.16E-15

830373
type: LocalParameter
units: 345062
value: 3.5998992E-16

348598
type: SpeciesReference
stoichiometry: 1.0
species: 764036

764036
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

348586
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348574
type: SpeciesReference
stoichiometry: 1.0
species: 767316

771436
type: Reaction
kinetic law: 348658
product: 348646
product: 348634
reactant: 348622
fast: false
reversible: false

348658
type: KineticLaw
local parameters: 830379
notes: k3*PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx

830379
type: LocalParameter
units: 344978
value: 5.4E-16

348646
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348634
type: SpeciesReference
stoichiometry: 1.0
species: 767356

348622
type: SpeciesReference
stoichiometry: 1.0
species: 764036

770076
type: Reaction
kinetic law: 345557
product: 345545
reactant: 345533
reactant: 345521
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true

345557
type: KineticLaw
local parameters: 830001
local parameters: 829998
notes: kf*CaM_minus_TR2_minus_Ca2_minus_PSD*Ca_minus_PSD-kb*CaM_minus_Ca3_minus_PSD

830001
type: LocalParameter
units: 344978
value: 1.0E-16

829998
type: LocalParameter
units: 345062
value: 3.6E-17

345545
type: SpeciesReference
stoichiometry: 1.0
species: 765916

345533
type: SpeciesReference
stoichiometry: 1.0
species: 765956

345521
type: SpeciesReference
stoichiometry: 1.0
species: 765896

774775
type: Reaction
kinetic law: 357434
product: 357422
reactant: 357410
reactant: 357398
fast: false
reversible: true

357434
type: KineticLaw
local parameters: 831196
local parameters: 831193
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx

831196
type: LocalParameter
units: 344978
value: 1.4E-17

831193
type: LocalParameter
units: 345062
value: 8.7498E-18

357422
type: SpeciesReference
stoichiometry: 1.0
species: 766916

357410
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357398
type: SpeciesReference
stoichiometry: 1.0
species: 768676

773376
type: Reaction
kinetic law: 353373
product: 353361
reactant: 353349
reactant: 353337
fast: false
reversible: true

353373
type: KineticLaw
local parameters: 830820
local parameters: 830817
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx

830820
type: LocalParameter
units: 344978
value: 2.0E-17

830817
type: LocalParameter
units: 345062
value: 2.77776E-19

353361
type: SpeciesReference
stoichiometry: 1.0
species: 765976

353349
type: SpeciesReference
stoichiometry: 1.0
species: 769136

353337
type: SpeciesReference
stoichiometry: 1.0
species: 768696

768876
type: Species
notes: This isn\'t explicitly present in the M&L model, but is obviously needed. I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim 7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs, which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984 Lets use a lower level of 30 nM, same ref....
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.5
initial amount: NaN
in compartment: 763757

776915
type: Reaction
kinetic law: 362634
product: 362622
product: 362610
reactant: 362598
fast: false
reversible: false

362634
type: KineticLaw
local parameters: 831676
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx

831676
type: LocalParameter
units: 344978
value: 6.03E-17

362622
type: SpeciesReference
stoichiometry: 1.0
species: 767636

362610
type: SpeciesReference
stoichiometry: 1.0
species: 764916

362598
type: SpeciesReference
stoichiometry: 1.0
species: 768396

773096
type: Reaction
kinetic law: 352694
product: 352682
reactant: 352670
reactant: 352658
notes: Best rates are from Conti et al Biochem 34 7979-7987 1995. Though these are for the Sertoli cell form, it looks like they carry nicely into alternatively spliced brain form. See Sette et al JBC 269:28 18271-18274 Km ~2 uM, Vmax est ~ 10 umol/min/mg for pure form. Brain protein is 93 kD but this was 67. So k3 ~10, k2 ~40, k1 ~4.2e-6
fast: false
reversible: true

352694
type: KineticLaw
local parameters: 830757
local parameters: 830754
notes: k1*cAMP*AC_slash_cAMP_minus_PDE-k2*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx

830757
type: LocalParameter
units: 344978
value: 3.6E-15

830754
type: LocalParameter
units: 345062
value: 2.2680162E-16

352682
type: SpeciesReference
stoichiometry: 1.0
species: 765576

352670
type: SpeciesReference
stoichiometry: 1.0
species: 765556

352658
type: SpeciesReference
stoichiometry: 1.0
species: 763916

773976
type: Reaction
kinetic law: 354819
product: 354807
reactant: 354794
reactant: 354782
fast: false
reversible: true

354819
type: KineticLaw
local parameters: 830953
local parameters: 830950
notes: k1*AMPAR_memb_slash_A831_star__B*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx

830953
type: LocalParameter
units: 344978
value: 2.0E-17

830950
type: LocalParameter
units: 345062
value: 2.77776E-19

354807
type: SpeciesReference
stoichiometry: 1.0
species: 766276

354794
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354782
type: SpeciesReference
stoichiometry: 1.0
species: 768536

774136
type: Reaction
kinetic law: 355206
product: 355194
reactant: 355182
reactant: 355170
fast: false
reversible: true

355206
type: KineticLaw
local parameters: 830989
local parameters: 830986
notes: k1*CaMKII_star__star__star__minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

830989
type: LocalParameter
units: 344978
value: 8.0E-18

830986
type: LocalParameter
units: 345062
value: 4.99998E-18

355194
type: SpeciesReference
stoichiometry: 1.0
species: 766456

355182
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355170
type: SpeciesReference
stoichiometry: 1.0
species: 765816

770376
type: Reaction
kinetic law: 346267
product: 346255
reactant: 346243
reactant: 346231
notes: Half-max at 20 nM CaM (Tang et al JBC 266:13 8595-8603 1991 kb/kf = 20 nM = 12000 #/cell so kf = kb/12000 = kb * 8.333e-5
fast: false
reversible: true

346267
type: KineticLaw
local parameters: 830091
local parameters: 830088
notes: kf*CaM_minus_Ca4*AC_slash_AC1-kb*AC_slash_AC1_minus_CaM

830091
type: LocalParameter
units: 344978
value: 9.0E-17

830088
type: LocalParameter
units: 345062
value: 4.4999712E-15

346255
type: SpeciesReference
stoichiometry: 1.0
species: 765456

346243
type: SpeciesReference
stoichiometry: 1.0
species: 765476

346231
type: SpeciesReference
stoichiometry: 1.0
species: 763796

772856
type: Reaction
kinetic law: 352112
product: 352100
reactant: 352088
reactant: 352076
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true

352112
type: KineticLaw
local parameters: 830700
local parameters: 830697
notes: k1*PP1_slash_PP1_minus_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx

830700
type: LocalParameter
units: 344978
value: 7.50006E-16

830697
type: LocalParameter
units: 345062
value: 5.81256E-17

352100
type: SpeciesReference
stoichiometry: 1.0
species: 765116

352088
type: SpeciesReference
stoichiometry: 1.0
species: 765076

352076
type: SpeciesReference
stoichiometry: 1.0
species: 765036

771076
type: Reaction
kinetic law: 347785
product: 347773
product: 347761
reactant: 347749
fast: false
reversible: false

347785
type: KineticLaw
local parameters: 830298
notes: k3*PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

830298
type: LocalParameter
units: 344978
value: 2.25E-16

347773
type: SpeciesReference
stoichiometry: 1.0
species: 763797

347761
type: SpeciesReference
stoichiometry: 1.0
species: 764616

347749
type: SpeciesReference
stoichiometry: 1.0
species: 763816

776335
type: Reaction
kinetic law: 361230
product: 361218
reactant: 361206
reactant: 361194
fast: false
reversible: true

361230
type: KineticLaw
local parameters: 831547
local parameters: 831544
notes: k1*AMPAR_memb_slash_A_B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx

831547
type: LocalParameter
units: 344978
value: 7.2E-16

831544
type: LocalParameter
units: 345062
value: 2.011824E-17

361218
type: SpeciesReference
stoichiometry: 1.0
species: 768116

768116
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

361206
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361194
type: SpeciesReference
stoichiometry: 1.0
species: 768656

772396
type: Reaction
kinetic law: 350991
product: 350979
product: 350967
reactant: 350955
fast: false
reversible: false

350991
type: KineticLaw
local parameters: 830595
notes: k3*PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx

830595
type: LocalParameter
units: 344978
value: 5.4E-16

350979
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350967
type: SpeciesReference
stoichiometry: 1.0
species: 768796

350955
type: SpeciesReference
stoichiometry: 1.0
species: 764456

772076
type: Reaction
kinetic law: 350206
product: 350194
product: 350182
reactant: 350170
fast: false
reversible: false

350206
type: KineticLaw
local parameters: 830523
notes: k3*PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx

830523
type: LocalParameter
units: 344978
value: 5.4E-16

350194
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350182
type: SpeciesReference
stoichiometry: 1.0
species: 768696

350170
type: SpeciesReference
stoichiometry: 1.0
species: 764296

771596
type: Reaction
kinetic law: 349044
product: 349032
product: 349020
reactant: 349008
fast: false
reversible: false

349044
type: KineticLaw
local parameters: 830415
notes: k3*PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx

830415
type: LocalParameter
units: 344978
value: 5.4E-16

349032
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349020
type: SpeciesReference
stoichiometry: 1.0
species: 767596

349008
type: SpeciesReference
stoichiometry: 1.0
species: 764076

776555
type: Reaction
kinetic law: 361762
product: 361750
product: 361738
reactant: 361726
fast: false
reversible: false

361762
type: KineticLaw
local parameters: 831595
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx

831595
type: LocalParameter
units: 344978
value: 1.8E-16

361750
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361738
type: SpeciesReference
stoichiometry: 1.0
species: 768536

361726
type: SpeciesReference
stoichiometry: 1.0
species: 768216

776855
type: Reaction
kinetic law: 362489
product: 362477
reactant: 362465
reactant: 362453
fast: false
reversible: true

362489
type: KineticLaw
local parameters: 831664
local parameters: 831661
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx

831664
type: LocalParameter
units: 344978
value: 7.2E-16

831661
type: LocalParameter
units: 345062
value: 2.011824E-17

362477
type: SpeciesReference
stoichiometry: 1.0
species: 768376

362465
type: SpeciesReference
stoichiometry: 1.0
species: 767636

362453
type: SpeciesReference
stoichiometry: 1.0
species: 768756

768956
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 763757

772996
type: Reaction
kinetic law: 352451
product: 352439
product: 352427
reactant: 352414
fast: false
reversible: false

352451
type: KineticLaw
local parameters: 830730
notes: k3*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx

830730
type: LocalParameter
units: 344978
value: 3.06E-18

352439
type: SpeciesReference
stoichiometry: 1.0
species: 765176

352427
type: SpeciesReference
stoichiometry: 1.0
species: 764996

352414
type: SpeciesReference
stoichiometry: 1.0
species: 765196

764736
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.90055555555556E-8
initial amount: NaN
in compartment: 763757

772016
type: Reaction
kinetic law: 350060
product: 350048
reactant: 350036
reactant: 350024
fast: false
reversible: true

350060
type: KineticLaw
local parameters: 830511
local parameters: 830508
notes: k1*AMPAR_memb_slash_A_B845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_slash_PKA_cplx

830511
type: LocalParameter
units: 344978
value: 2.16E-15

830508
type: LocalParameter
units: 345062
value: 3.999888E-17

350048
type: SpeciesReference
stoichiometry: 1.0
species: 764276

350036
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350024
type: SpeciesReference
stoichiometry: 1.0
species: 768656

770756
type: Reaction
kinetic law: 347111
product: 347099
product: 347087
reactant: 347075
fast: false
reversible: true

347111
type: KineticLaw
local parameters: 830205
local parameters: 830202
notes: kf*AMPAR_memb_slash_A831_star__B-kb*AMPAR_slash_A831_star__B*Anchor

830205
type: LocalParameter
units: 345062
value: 0.0

830202
type: LocalParameter
units: 344978
value: 8.0E-21

347099
type: SpeciesReference
stoichiometry: 1.0
species: 768436

347087
type: SpeciesReference
stoichiometry: 1.0
species: 767316

347075
type: SpeciesReference
stoichiometry: 1.0
species: 768536

776075
type: Reaction
kinetic law: 360601
product: 360589
product: 360577
reactant: 360565
fast: false
reversible: false

360601
type: KineticLaw
local parameters: 831487
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx

831487
type: LocalParameter
units: 344978
value: 1.8E-16

360589
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360577
type: SpeciesReference
stoichiometry: 1.0
species: 767496

360565
type: SpeciesReference
stoichiometry: 1.0
species: 767976

770976
type: Reaction
kinetic law: 347579
product: 347567
reactant: 347555
fast: false
reversible: true

347579
type: KineticLaw
local parameters: 830271
local parameters: 830268
notes: kf*PKC_minus_control-kb*PKC_minus_active

830271
type: LocalParameter
units: 344978
value: 2.25E-16

830268
type: LocalParameter
units: 344978
value: 2.25E-16

347567
type: SpeciesReference
stoichiometry: 1.0
species: 767136

347555
type: SpeciesReference
stoichiometry: 1.0
species: 768936

776415
type: Reaction
kinetic law: 361424
product: 361412
reactant: 361400
reactant: 361388
fast: false
reversible: true

361424
type: KineticLaw
local parameters: 831565
local parameters: 831562
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx

831565
type: LocalParameter
units: 344978
value: 7.2E-16

831562
type: LocalParameter
units: 345062
value: 2.011824E-17

361412
type: SpeciesReference
stoichiometry: 1.0
species: 768156

361400
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361388
type: SpeciesReference
stoichiometry: 1.0
species: 768776

770256
type: Reaction
kinetic law: 345979
product: 345967
reactant: 345955
reactant: 345943
notes: For now let us set this to the same Km (1e-7M) as site B. This gives kf/kb = .7e-7M * 1e6 / (6e5^2) : 1/(6e5^2) = 2e-13:2.77e-12 Smith et al have better values. They say that this is cooperative, so the consts are now kf/kb =8.3e-4
fast: false
reversible: true

345979
type: KineticLaw
local parameters: 830055
local parameters: 830052
notes: kf*PKA_slash_R2C2_minus_cAMP*cAMP-kb*PKA_slash_R2C2_minus_cAMP2

830055
type: LocalParameter
units: 344978
value: 2.97E-15

830052
type: LocalParameter
units: 345062
value: 4.86E-15

345967
type: SpeciesReference
stoichiometry: 1.0
species: 765316

345955
type: SpeciesReference
stoichiometry: 1.0
species: 763916

345943
type: SpeciesReference
stoichiometry: 1.0
species: 765296

772356
type: Reaction
kinetic law: 350895
product: 350882
product: 350869
reactant: 350857
fast: false
reversible: false

350895
type: KineticLaw
local parameters: 830586
notes: k3*PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx

830586
type: LocalParameter
units: 344978
value: 5.4E-16

350882
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350869
type: SpeciesReference
stoichiometry: 1.0
species: 768796

350857
type: SpeciesReference
stoichiometry: 1.0
species: 764436

773716
type: Reaction
kinetic law: 354190
product: 354178
product: 354166
reactant: 354154
fast: false
reversible: false

354190
type: KineticLaw
local parameters: 830895
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx

830895
type: LocalParameter
units: 344978
value: 5.0E-18

354178
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354166
type: SpeciesReference
stoichiometry: 1.0
species: 768816

354154
type: SpeciesReference
stoichiometry: 1.0
species: 766136

766136
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 763776

772656
type: Reaction
kinetic law: 351627
product: 351615
reactant: 351603
reactant: 351591
notes: Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
fast: false
reversible: true

351627
type: KineticLaw
local parameters: 830655
local parameters: 830652
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx

830655
type: LocalParameter
units: 344978
value: 2.16E-15

830652
type: LocalParameter
units: 345062
value: 1.1894364E-17

351615
type: SpeciesReference
stoichiometry: 1.0
species: 764696

351603
type: SpeciesReference
stoichiometry: 1.0
species: 769036

351591
type: SpeciesReference
stoichiometry: 1.0
species: 764676

771656
type: Reaction
kinetic law: 349189
product: 349177
reactant: 349165
reactant: 349153
fast: false
reversible: true

349189
type: KineticLaw
local parameters: 830430
local parameters: 830427
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx

830430
type: LocalParameter
units: 344978
value: 2.16E-15

830427
type: LocalParameter
units: 345062
value: 3.5998992E-16

349177
type: SpeciesReference
stoichiometry: 1.0
species: 764116

349165
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349153
type: SpeciesReference
stoichiometry: 1.0
species: 767556

775495
type: Reaction
kinetic law: 359199
product: 359187
reactant: 359175
reactant: 359163
fast: false
reversible: true

359199
type: KineticLaw
local parameters: 831358
local parameters: 831355
notes: k1*PP1_slash_PP1_minus_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx

831358
type: LocalParameter
units: 344978
value: 1.224E-16

831355
type: LocalParameter
units: 345062
value: 3.0779838E-17

359187
type: SpeciesReference
stoichiometry: 1.0
species: 767696

359175
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359163
type: SpeciesReference
stoichiometry: 1.0
species: 765036

773736
type: Reaction
kinetic law: 354238
product: 354226
reactant: 354214
reactant: 354202
fast: false
reversible: true

354238
type: KineticLaw
local parameters: 830901
local parameters: 830898
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx

830901
type: LocalParameter
units: 344978
value: 2.0E-17

830898
type: LocalParameter
units: 345062
value: 2.77776E-19

354226
type: SpeciesReference
stoichiometry: 1.0
species: 766156

354214
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354202
type: SpeciesReference
stoichiometry: 1.0
species: 768736

775135
type: Reaction
kinetic law: 358303
product: 358291
reactant: 358279
reactant: 358267
fast: false
reversible: true

358303
type: KineticLaw
local parameters: 831277
local parameters: 831274
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx

831277
type: LocalParameter
units: 344978
value: 1.4E-17

831274
type: LocalParameter
units: 345062
value: 8.7498E-18

358291
type: SpeciesReference
stoichiometry: 1.0
species: 767096

358279
type: SpeciesReference
stoichiometry: 1.0
species: 766376

358267
type: SpeciesReference
stoichiometry: 1.0
species: 768576

771336
type: Reaction
kinetic law: 348415
product: 348403
reactant: 348391
reactant: 348379
fast: false
reversible: true

348415
type: KineticLaw
local parameters: 830358
local parameters: 830355
notes: k1*PP1_PSD_slash_I1*PKA_minus_active-k2*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx

830358
type: LocalParameter
units: 344978
value: 3.24E-15

830355
type: LocalParameter
units: 345062
value: 5.99994E-17

348403
type: SpeciesReference
stoichiometry: 1.0
species: 764016

348391
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348379
type: SpeciesReference
stoichiometry: 1.0
species: 766296

773956
type: Reaction
kinetic law: 354770
product: 354758
product: 354746
reactant: 354733
fast: false
reversible: false

354770
type: KineticLaw
local parameters: 830947
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx

830947
type: LocalParameter
units: 344978
value: 5.0E-18

354758
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354746
type: SpeciesReference
stoichiometry: 1.0
species: 768636

354733
type: SpeciesReference
stoichiometry: 1.0
species: 766256

772736
type: Reaction
kinetic law: 351822
product: 351809
reactant: 351797
reactant: 351785
notes: See Hanson and Schulman again, for afterburst rates of phosph.
fast: false
reversible: true

351822
type: KineticLaw
local parameters: 830673
local parameters: 830670
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx

830673
type: LocalParameter
units: 344978
value: 2.16E-15

830670
type: LocalParameter
units: 345062
value: 7.714278E-18

351809
type: SpeciesReference
stoichiometry: 1.0
species: 764736

351797
type: SpeciesReference
stoichiometry: 1.0
species: 769056

351785
type: SpeciesReference
stoichiometry: 1.0
species: 764676

774675
type: Reaction
kinetic law: 357145
product: 357133
reactant: 357121
reactant: 357109
fast: false
reversible: true

357145
type: KineticLaw
local parameters: 831169
local parameters: 831166
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx

831169
type: LocalParameter
units: 344978
value: 6.8E-18

831166
type: LocalParameter
units: 345062
value: 8.7498E-18

357133
type: SpeciesReference
stoichiometry: 1.0
species: 766856

357121
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357109
type: SpeciesReference
stoichiometry: 1.0
species: 768636

772296
type: Reaction
kinetic law: 350748
product: 350735
reactant: 350723
reactant: 350711
fast: false
reversible: true

350748
type: KineticLaw
local parameters: 830574
local parameters: 830571
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx

830574
type: LocalParameter
units: 344978
value: 2.16E-15

830571
type: LocalParameter
units: 345062
value: 3.999888E-17

350735
type: SpeciesReference
stoichiometry: 1.0
species: 764416

350723
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350711
type: SpeciesReference
stoichiometry: 1.0
species: 768536

771816
type: Reaction
kinetic law: 349575
product: 349563
reactant: 349551
reactant: 349539
fast: false
reversible: true

349575
type: KineticLaw
local parameters: 830466
local parameters: 830463
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx

830466
type: LocalParameter
units: 344978
value: 2.16E-15

830463
type: LocalParameter
units: 345062
value: 3.5998992E-16

349563
type: SpeciesReference
stoichiometry: 1.0
species: 764177

349551
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349539
type: SpeciesReference
stoichiometry: 1.0
species: 767496

770636
type: Reaction
kinetic law: 346834
product: 346822
product: 346810
reactant: 346798
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true

346834
type: KineticLaw
local parameters: 830169
local parameters: 830166
notes: kf*PP1_PSD_slash_PP1_minus_I1-kb*PP1_PSD_slash_I1*PP1_minus_active_PSD

830169
type: LocalParameter
units: 345062
value: 0.0

830166
type: LocalParameter
units: 344978
value: 1.0E-17

346822
type: SpeciesReference
stoichiometry: 1.0
species: 766376

346810
type: SpeciesReference
stoichiometry: 1.0
species: 766296

346798
type: SpeciesReference
stoichiometry: 1.0
species: 766356

771356
type: Reaction
kinetic law: 348463
product: 348451
product: 348439
reactant: 348427
fast: false
reversible: false

348463
type: KineticLaw
local parameters: 830361
notes: k3*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx

830361
type: LocalParameter
units: 344978
value: 8.1E-16

348451
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348439
type: SpeciesReference
stoichiometry: 1.0
species: 766316

348427
type: SpeciesReference
stoichiometry: 1.0
species: 764016

775335
type: Reaction
kinetic law: 358800
product: 358788
reactant: 358776
reactant: 358763
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

358800
type: KineticLaw
local parameters: 831322
local parameters: 831319
notes: k1*CaM_slash_neurogranin_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx

831322
type: LocalParameter
units: 344978
value: 2.106E-16

831319
type: LocalParameter
units: 345062
value: 1.020006E-18

358788
type: SpeciesReference
stoichiometry: 1.0
species: 767216

358776
type: SpeciesReference
stoichiometry: 1.0
species: 767136

358763
type: SpeciesReference
stoichiometry: 1.0
species: 764916

773476
type: Reaction
kinetic law: 353614
product: 353602
product: 353590
reactant: 353578
fast: false
reversible: false

353614
type: KineticLaw
local parameters: 830841
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx

830841
type: LocalParameter
units: 344978
value: 5.0E-18

353602
type: SpeciesReference
stoichiometry: 1.0
species: 769136

353590
type: SpeciesReference
stoichiometry: 1.0
species: 768616

353578
type: SpeciesReference
stoichiometry: 1.0
species: 766016

772756
type: Reaction
kinetic law: 351870
product: 351858
product: 351846
reactant: 351834
fast: false
reversible: false

351870
type: KineticLaw
local parameters: 830676
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx

830676
type: LocalParameter
units: 344978
value: 5.4E-16

351858
type: SpeciesReference
stoichiometry: 1.0
species: 769056

351846
type: SpeciesReference
stoichiometry: 1.0
species: 764656

351834
type: SpeciesReference
stoichiometry: 1.0
species: 764736

770656
type: Reaction
kinetic law: 346883
product: 346871
reactant: 346858
reactant: 346846
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true

346883
type: KineticLaw
local parameters: 830175
local parameters: 830172
notes: kf*PP1_PSD_slash_I1_star_*PP1_minus_active_PSD-kb*PP1_PSD_slash_PP1_minus_I1_star_

830175
type: LocalParameter
units: 344978
value: 1.0E-18

830172
type: LocalParameter
units: 345062
value: 4.9998E-15

346871
type: SpeciesReference
stoichiometry: 1.0
species: 766336

346858
type: SpeciesReference
stoichiometry: 1.0
species: 766376

346846
type: SpeciesReference
stoichiometry: 1.0
species: 766316

776295
type: Reaction
kinetic law: 361134
product: 361122
reactant: 361110
reactant: 361097
fast: false
reversible: true

361134
type: KineticLaw
local parameters: 831538
local parameters: 831535
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx

831538
type: LocalParameter
units: 344978
value: 7.2E-16

831535
type: LocalParameter
units: 345062
value: 2.011824E-17

361122
type: SpeciesReference
stoichiometry: 1.0
species: 768096

361110
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361097
type: SpeciesReference
stoichiometry: 1.0
species: 768696

766476
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763776

770296
type: Reaction
kinetic law: 346075
product: 346063
reactant: 346051
reactant: 346039
fast: false
reversible: true

346075
type: KineticLaw
local parameters: 830067
local parameters: 830064
notes: kf*cAMP*PKA_slash_R2C2_minus_cAMP3-kb*PKA_slash_R2C2_minus_cAMP4

830067
type: LocalParameter
units: 344978
value: 2.925E-15

830064
type: LocalParameter
units: 345062
value: 6.750054E-15

346063
type: SpeciesReference
stoichiometry: 1.0
species: 765356

346051
type: SpeciesReference
stoichiometry: 1.0
species: 765336

346039
type: SpeciesReference
stoichiometry: 1.0
species: 763916

770996
type: Reaction
kinetic law: 347615
product: 347603
reactant: 347591
fast: false
reversible: true

347615
type: KineticLaw
local parameters: 830277
local parameters: 830274
notes: kf*Ca_control_PSD-kb*Ca_minus_PSD

830277
type: LocalParameter
units: 344978
value: 1.0E-15

830274
type: LocalParameter
units: 344978
value: 1.0E-15

347603
type: SpeciesReference
stoichiometry: 1.0
species: 765956

347591
type: SpeciesReference
stoichiometry: 1.0
species: 768976

771736
type: Reaction
kinetic law: 349382
product: 349370
reactant: 349358
reactant: 349346
fast: false
reversible: true

349382
type: KineticLaw
local parameters: 830448
local parameters: 830445
notes: k1*AMPAR_slash_A831_star__B845_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx

830448
type: LocalParameter
units: 344978
value: 2.16E-15

830445
type: LocalParameter
units: 345062
value: 3.5998992E-16

349370
type: SpeciesReference
stoichiometry: 1.0
species: 764156

349358
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349346
type: SpeciesReference
stoichiometry: 1.0
species: 767596

772156
type: Reaction
kinetic law: 350406
product: 350393
product: 350380
reactant: 350367
fast: false
reversible: false

350406
type: KineticLaw
local parameters: 830541
notes: k3*PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx

830541
type: LocalParameter
units: 344978
value: 5.4E-16

350393
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350380
type: SpeciesReference
stoichiometry: 1.0
species: 768656

350367
type: SpeciesReference
stoichiometry: 1.0
species: 764336

774335
type: Reaction
kinetic law: 355742
product: 355730
product: 355718
reactant: 355706
fast: false
reversible: false

355742
type: KineticLaw
local parameters: 831037
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx

831037
type: LocalParameter
units: 344978
value: 1.7E-18

355730
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355718
type: SpeciesReference
stoichiometry: 1.0
species: 768716

355706
type: SpeciesReference
stoichiometry: 1.0
species: 766556

772416
type: Reaction
kinetic law: 351040
product: 351028
reactant: 351015
reactant: 351003
fast: false
reversible: true

351040
type: KineticLaw
local parameters: 830601
local parameters: 830598
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx

830601
type: LocalParameter
units: 344978
value: 2.16E-15

830598
type: LocalParameter
units: 345062
value: 3.999888E-17

351028
type: SpeciesReference
stoichiometry: 1.0
species: 764476

351015
type: SpeciesReference
stoichiometry: 1.0
species: 763956

351003
type: SpeciesReference
stoichiometry: 1.0
species: 768556

775735
type: Reaction
kinetic law: 359781
product: 359768
reactant: 359755
reactant: 359743
fast: false
reversible: true

359781
type: KineticLaw
local parameters: 831412
local parameters: 831409
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx

831412
type: LocalParameter
units: 344978
value: 7.2E-16

831409
type: LocalParameter
units: 345062
value: 1.8106416E-16

359768
type: SpeciesReference
stoichiometry: 1.0
species: 767816

359755
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359743
type: SpeciesReference
stoichiometry: 1.0
species: 767576

774375
type: Reaction
kinetic law: 355935
product: 355923
product: 355911
reactant: 355898
fast: false
reversible: false

355935
type: KineticLaw
local parameters: 831055
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx

831055
type: LocalParameter
units: 344978
value: 1.7E-18

355923
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355911
type: SpeciesReference
stoichiometry: 1.0
species: 768536

355898
type: SpeciesReference
stoichiometry: 1.0
species: 766596

770136
type: Reaction
kinetic law: 345690
product: 345678
reactant: 345666
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true

345690
type: KineticLaw
local parameters: 830019
local parameters: 830016
notes: kf*CaM_slash_neurogranin_star__PSD-kb*CaM_slash_neurogranin_PSD

830019
type: LocalParameter
units: 344978
value: 0.0

830016
type: LocalParameter
units: 344978
value: 5.0E-20

345678
type: SpeciesReference
stoichiometry: 1.0
species: 764916

345666
type: SpeciesReference
stoichiometry: 1.0
species: 764936

775295
type: Reaction
kinetic law: 358702
product: 358689
reactant: 358677
reactant: 358665
notes: Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4
fast: false
reversible: true

358702
type: KineticLaw
local parameters: 831313
local parameters: 831310
notes: k1*AC_slash_AC2*PKC_minus_active-k2*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx

831313
type: LocalParameter
units: 344978
value: 1.44E-15

831310
type: LocalParameter
units: 345062
value: 5.399946E-17

358689
type: SpeciesReference
stoichiometry: 1.0
species: 767196

358677
type: SpeciesReference
stoichiometry: 1.0
species: 767136

358665
type: SpeciesReference
stoichiometry: 1.0
species: 765516

774895
type: Reaction
kinetic law: 357724
product: 357712
reactant: 357699
reactant: 357687
fast: false
reversible: true

357724
type: KineticLaw
local parameters: 831223
local parameters: 831220
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx

831223
type: LocalParameter
units: 344978
value: 1.4E-17

831220
type: LocalParameter
units: 345062
value: 8.7498E-18

357712
type: SpeciesReference
stoichiometry: 1.0
species: 766976

357699
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357687
type: SpeciesReference
stoichiometry: 1.0
species: 768756

776695
type: Reaction
kinetic law: 362101
product: 362089
reactant: 362076
reactant: 362064
fast: false
reversible: true

362101
type: KineticLaw
local parameters: 831628
local parameters: 831625
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx

831628
type: LocalParameter
units: 344978
value: 7.2E-16

831625
type: LocalParameter
units: 345062
value: 2.011824E-17

362089
type: SpeciesReference
stoichiometry: 1.0
species: 768296

362076
type: SpeciesReference
stoichiometry: 1.0
species: 767636

362064
type: SpeciesReference
stoichiometry: 1.0
species: 768676

770156
type: Reaction
kinetic law: 345738
product: 345726
product: 345714
reactant: 345702
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true

345738
type: KineticLaw
local parameters: 830025
local parameters: 830022
notes: kf*PP1_slash_PP1_minus_I1-kb*PP1_minus_active*PP1_slash_I1

830025
type: LocalParameter
units: 345062
value: 0.0

830022
type: LocalParameter
units: 344978
value: 9.0E-17

345726
type: SpeciesReference
stoichiometry: 1.0
species: 764996

345714
type: SpeciesReference
stoichiometry: 1.0
species: 763797

345702
type: SpeciesReference
stoichiometry: 1.0
species: 765056

772056
type: Reaction
kinetic law: 350158
product: 350146
reactant: 350133
reactant: 350121
fast: false
reversible: true

350158
type: KineticLaw
local parameters: 830520
local parameters: 830517
notes: k1*AMPAR_memb_slash_A845_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx

830520
type: LocalParameter
units: 344978
value: 2.16E-15

830517
type: LocalParameter
units: 345062
value: 3.999888E-17

350146
type: SpeciesReference
stoichiometry: 1.0
species: 764296

350133
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350121
type: SpeciesReference
stoichiometry: 1.0
species: 768596

771576
type: Reaction
kinetic law: 348996
product: 348984
reactant: 348972
reactant: 348960
fast: false
reversible: true

348996
type: KineticLaw
local parameters: 830412
local parameters: 830409
notes: k1*AMPAR_slash_A831_star__B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx

830412
type: LocalParameter
units: 344978
value: 2.16E-15

830409
type: LocalParameter
units: 345062
value: 3.5998992E-16

348984
type: SpeciesReference
stoichiometry: 1.0
species: 764076

348972
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348960
type: SpeciesReference
stoichiometry: 1.0
species: 767316

770601
type: Reaction
kinetic law: 346750
product: 346738
reactant: 346726
fast: false
reversible: true

346750
type: KineticLaw
local parameters: 830157
local parameters: 830154
notes: kf*Ca_control_cyt-kb*Ca

830157
type: LocalParameter
units: 344978
value: 9.0E-15

830154
type: LocalParameter
units: 344978
value: 9.0E-15

346738
type: SpeciesReference
stoichiometry: 1.0
species: 763936

346726
type: SpeciesReference
stoichiometry: 1.0
species: 768956

775375
type: Reaction
kinetic law: 358898
product: 358886
reactant: 358873
reactant: 358861
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

358898
type: KineticLaw
local parameters: 831331
local parameters: 831328
notes: k1*CaM_slash_neurogranin_minus_CaM_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx

831331
type: LocalParameter
units: 344978
value: 1.26E-16

831328
type: LocalParameter
units: 345062
value: 6.11982E-19

358886
type: SpeciesReference
stoichiometry: 1.0
species: 767236

767236
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

358873
type: SpeciesReference
stoichiometry: 1.0
species: 767136

358861
type: SpeciesReference
stoichiometry: 1.0
species: 764896

776115
type: Reaction
kinetic law: 360698
product: 360686
product: 360674
reactant: 360662
fast: false
reversible: false

360698
type: KineticLaw
local parameters: 831496
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx

831496
type: LocalParameter
units: 344978
value: 1.8E-16

360686
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360674
type: SpeciesReference
stoichiometry: 1.0
species: 767336

360662
type: SpeciesReference
stoichiometry: 1.0
species: 767996

773696
type: Reaction
kinetic law: 354142
product: 354130
reactant: 354118
reactant: 354106
fast: false
reversible: true

354142
type: KineticLaw
local parameters: 830892
local parameters: 830889
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx

830892
type: LocalParameter
units: 344978
value: 2.0E-17

830889
type: LocalParameter
units: 345062
value: 2.77776E-19

354130
type: SpeciesReference
stoichiometry: 1.0
species: 766136

354118
type: SpeciesReference
stoichiometry: 1.0
species: 769136

354106
type: SpeciesReference
stoichiometry: 1.0
species: 768796

775395
type: Reaction
kinetic law: 358958
product: 358946
product: 358934
product: 358922
reactant: 358910
fast: false
reversible: false

358958
type: KineticLaw
local parameters: 831334
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx

831334
type: LocalParameter
units: 344978
value: 3.15E-17

358946
type: SpeciesReference
stoichiometry: 1.0
species: 767136

358934
type: SpeciesReference
stoichiometry: 1.0
species: 764936

358922
type: SpeciesReference
stoichiometry: 1.0
species: 764876

358910
type: SpeciesReference
stoichiometry: 1.0
species: 767236

772976
type: Reaction
kinetic law: 352402
product: 352390
reactant: 352377
reactant: 352365
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true

352402
type: KineticLaw
local parameters: 830727
local parameters: 830724
notes: k1*PP1_slash_I1_star_*CaNAB_minus_Ca4-k2*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx

830727
type: LocalParameter
units: 344978
value: 1.224E-17

830724
type: LocalParameter
units: 345062
value: 3.0779838E-18

352390
type: SpeciesReference
stoichiometry: 1.0
species: 765196

352377
type: SpeciesReference
stoichiometry: 1.0
species: 765176

352365
type: SpeciesReference
stoichiometry: 1.0
species: 765016

770736
type: Reaction
kinetic law: 347063
product: 347051
product: 347039
reactant: 347027
fast: false
reversible: true

347063
type: KineticLaw
local parameters: 830199
local parameters: 830196
notes: kf*AMPAR_memb_slash_A_B831_star_-kb*AMPAR_slash_A_B831_star_*Anchor

830199
type: LocalParameter
units: 345062
value: 0.0

830196
type: LocalParameter
units: 344978
value: 8.0E-21

347051
type: SpeciesReference
stoichiometry: 1.0
species: 768436

347039
type: SpeciesReference
stoichiometry: 1.0
species: 767516

347027
type: SpeciesReference
stoichiometry: 1.0
species: 768556

769916
type: Reaction
kinetic law: 345175
product: 345162
reactant: 345149
reactant: 345136
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true

345175
type: KineticLaw
local parameters: 829953
local parameters: 829950
notes: kf*PP1_slash_I1_star_*PP1_minus_active-kb*PP1_slash_PP1_minus_I1_star_

829953
type: LocalParameter
units: 344978
value: 9.0E-18

829950
type: LocalParameter
units: 345062
value: 4.4998254E-14

345162
type: SpeciesReference
stoichiometry: 1.0
species: 765036

345149
type: SpeciesReference
stoichiometry: 1.0
species: 763797

345136
type: SpeciesReference
stoichiometry: 1.0
species: 765016

774176
type: Reaction
kinetic law: 355302
product: 355290
reactant: 355278
reactant: 355266
fast: false
reversible: true

355302
type: KineticLaw
local parameters: 830998
local parameters: 830995
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx

830998
type: LocalParameter
units: 344978
value: 6.8E-18

830995
type: LocalParameter
units: 345062
value: 8.7498E-18

355290
type: SpeciesReference
stoichiometry: 1.0
species: 766476

355278
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355266
type: SpeciesReference
stoichiometry: 1.0
species: 768696

769236
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 763757

771136
type: Reaction
kinetic law: 347931
product: 347919
reactant: 347906
reactant: 347893
fast: false
reversible: true

347931
type: KineticLaw
local parameters: 830313
local parameters: 830310
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

830313
type: LocalParameter
units: 344978
value: 9.0E-16

830310
type: LocalParameter
units: 345062
value: 2.2062942E-16

347919
type: SpeciesReference
stoichiometry: 1.0
species: 763856

347906
type: SpeciesReference
stoichiometry: 1.0
species: 763797

347893
type: SpeciesReference
stoichiometry: 1.0
species: 764656

775895
type: Reaction
kinetic law: 360167
product: 360155
reactant: 360143
reactant: 360131
fast: false
reversible: true

360167
type: KineticLaw
local parameters: 831448
local parameters: 831445
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx

831448
type: LocalParameter
units: 344978
value: 7.2E-16

831445
type: LocalParameter
units: 345062
value: 1.8106416E-16

360155
type: SpeciesReference
stoichiometry: 1.0
species: 767896

360143
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360131
type: SpeciesReference
stoichiometry: 1.0
species: 767496

770536
type: Reaction
kinetic law: 346616
product: 346604
product: 346592
reactant: 346580
notes: Rates set by the translocation experiments of Shen and Meyer, Science 1999.
fast: false
reversible: true

346616
type: KineticLaw
local parameters: 830139
local parameters: 830136
notes: kf*CaMKII_minus_PSD-kb*CaMKII_slash_CaMKII*NMDAR

830139
type: LocalParameter
units: 345062
value: 5.4E-21

830136
type: LocalParameter
units: 344978
value: 3.0E-18

346604
type: SpeciesReference
stoichiometry: 1.0
species: 767616

346592
type: SpeciesReference
stoichiometry: 1.0
species: 764596

346580
type: SpeciesReference
stoichiometry: 1.0
species: 765796

776055
type: Reaction
kinetic law: 360553
product: 360540
reactant: 360528
reactant: 360516
fast: false
reversible: true

360553
type: KineticLaw
local parameters: 831484
local parameters: 831481
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx

831484
type: LocalParameter
units: 344978
value: 7.2E-16

831481
type: LocalParameter
units: 345062
value: 1.8106416E-16

360540
type: SpeciesReference
stoichiometry: 1.0
species: 767976

360528
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360516
type: SpeciesReference
stoichiometry: 1.0
species: 767456

774196
type: Reaction
kinetic law: 355350
product: 355338
product: 355326
reactant: 355314
fast: false
reversible: false

355350
type: KineticLaw
local parameters: 831001
notes: k3*PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx

831001
type: LocalParameter
units: 344978
value: 1.7E-18

355338
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355326
type: SpeciesReference
stoichiometry: 1.0
species: 768656

355314
type: SpeciesReference
stoichiometry: 1.0
species: 766476

776315
type: Reaction
kinetic law: 361182
product: 361170
product: 361158
reactant: 361146
fast: false
reversible: false

361182
type: KineticLaw
local parameters: 831541
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx

831541
type: LocalParameter
units: 344978
value: 1.8E-16

361170
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361158
type: SpeciesReference
stoichiometry: 1.0
species: 768596

361146
type: SpeciesReference
stoichiometry: 1.0
species: 768096

771956
type: Reaction
kinetic law: 349915
product: 349903
product: 349891
reactant: 349879
fast: false
reversible: false

349915
type: KineticLaw
local parameters: 830496
notes: k3*PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx

830496
type: LocalParameter
units: 344978
value: 5.4E-16

349903
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349891
type: SpeciesReference
stoichiometry: 1.0
species: 767436

349879
type: SpeciesReference
stoichiometry: 1.0
species: 764236

776655
type: Reaction
kinetic law: 362003
product: 361991
reactant: 361979
reactant: 361967
fast: false
reversible: true

362003
type: KineticLaw
local parameters: 831619
local parameters: 831616
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx

831619
type: LocalParameter
units: 344978
value: 7.2E-16

831616
type: LocalParameter
units: 345062
value: 2.011824E-17

361991
type: SpeciesReference
stoichiometry: 1.0
species: 768276

361979
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361967
type: SpeciesReference
stoichiometry: 1.0
species: 768736

771216
type: Reaction
kinetic law: 348127
product: 348114
reactant: 348101
reactant: 348089
fast: false
reversible: true

348127
type: KineticLaw
local parameters: 830331
local parameters: 830328
notes: k1*CaMKII_slash_CaMK_minus_thr305*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

830331
type: LocalParameter
units: 344978
value: 9.0E-16

830328
type: LocalParameter
units: 345062
value: 2.2062942E-16

348114
type: SpeciesReference
stoichiometry: 1.0
species: 763896

348101
type: SpeciesReference
stoichiometry: 1.0
species: 763797

348089
type: SpeciesReference
stoichiometry: 1.0
species: 764776

775035
type: Reaction
kinetic law: 358062
product: 358050
product: 358038
reactant: 358026
fast: false
reversible: false

358062
type: KineticLaw
local parameters: 831253
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx

831253
type: LocalParameter
units: 344978
value: 3.5E-18

358050
type: SpeciesReference
stoichiometry: 1.0
species: 766376

358038
type: SpeciesReference
stoichiometry: 1.0
species: 768776

358026
type: SpeciesReference
stoichiometry: 1.0
species: 767036

774555
type: Reaction
kinetic law: 356713
product: 356701
product: 356689
reactant: 356677
fast: false
reversible: false

356713
type: KineticLaw
local parameters: 831127
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx

831127
type: LocalParameter
units: 344978
value: 1.7E-18

356701
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356689
type: SpeciesReference
stoichiometry: 1.0
species: 768556

356677
type: SpeciesReference
stoichiometry: 1.0
species: 766756

771976
type: Reaction
kinetic law: 349963
product: 349951
reactant: 349939
reactant: 349927
fast: false
reversible: true

349963
type: KineticLaw
local parameters: 830502
local parameters: 830499
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx

830502
type: LocalParameter
units: 344978
value: 2.16E-15

830499
type: LocalParameter
units: 345062
value: 3.5998992E-16

349951
type: SpeciesReference
stoichiometry: 1.0
species: 764256

349939
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349927
type: SpeciesReference
stoichiometry: 1.0
species: 767576

772136
type: Reaction
kinetic law: 350354
product: 350341
reactant: 350328
reactant: 350316
fast: false
reversible: true

350354
type: KineticLaw
local parameters: 830538
local parameters: 830535
notes: k1*AMPAR_memb_slash_A_B*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx

830538
type: LocalParameter
units: 344978
value: 2.16E-15

830535
type: LocalParameter
units: 345062
value: 3.999888E-17

350341
type: SpeciesReference
stoichiometry: 1.0
species: 764336

350328
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350316
type: SpeciesReference
stoichiometry: 1.0
species: 768516

776895
type: Reaction
kinetic law: 362586
product: 362573
reactant: 362561
reactant: 362549
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true

362586
type: KineticLaw
local parameters: 831673
local parameters: 831670
notes: k1*CaM_slash_neurogranin_star__PSD*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx

831673
type: LocalParameter
units: 344978
value: 2.403E-16

831670
type: LocalParameter
units: 345062
value: 3.336012E-18

362573
type: SpeciesReference
stoichiometry: 1.0
species: 768396

362561
type: SpeciesReference
stoichiometry: 1.0
species: 767636

362549
type: SpeciesReference
stoichiometry: 1.0
species: 764936

771516
type: Reaction
kinetic law: 348851
product: 348839
product: 348827
reactant: 348814
fast: false
reversible: false

348851
type: KineticLaw
local parameters: 830397
notes: k3*PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx

830397
type: LocalParameter
units: 344978
value: 5.4E-16

348839
type: SpeciesReference
stoichiometry: 1.0
species: 763956

348827
type: SpeciesReference
stoichiometry: 1.0
species: 767576

348814
type: SpeciesReference
stoichiometry: 1.0
species: 764056

775955
type: Reaction
kinetic law: 360312
product: 360300
product: 360288
reactant: 360276
fast: false
reversible: false

360312
type: KineticLaw
local parameters: 831460
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx

831460
type: LocalParameter
units: 344978
value: 1.8E-16

360300
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360288
type: SpeciesReference
stoichiometry: 1.0
species: 767376

360276
type: SpeciesReference
stoichiometry: 1.0
species: 767916

773136
type: Reaction
kinetic law: 352792
product: 352780
reactant: 352768
reactant: 352756
notes: This form has about twice the activity of the unphosphorylated form. See Sette et al JBC 269:28 18271-18274 1994. We\'ll ignore cGMP effects for now.
fast: false
reversible: true

352792
type: KineticLaw
local parameters: 830766
local parameters: 830763
notes: k1*cAMP*AC_slash_cAMP_minus_PDE_star_-k2*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx

830766
type: LocalParameter
units: 344978
value: 7.2E-15

830763
type: LocalParameter
units: 345062
value: 4.5359838E-16

352780
type: SpeciesReference
stoichiometry: 1.0
species: 765616

352768
type: SpeciesReference
stoichiometry: 1.0
species: 765596

352756
type: SpeciesReference
stoichiometry: 1.0
species: 763916

772636
type: Reaction
kinetic law: 351578
product: 351566
product: 351554
reactant: 351541
fast: false
reversible: false

351578
type: KineticLaw
local parameters: 830649
notes: k3*PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx

830649
type: LocalParameter
units: 344978
value: 5.4E-16

351566
type: SpeciesReference
stoichiometry: 1.0
species: 763956

351554
type: SpeciesReference
stoichiometry: 1.0
species: 768636

351541
type: SpeciesReference
stoichiometry: 1.0
species: 764576

775055
type: Reaction
kinetic law: 358110
product: 358098
reactant: 358086
reactant: 358074
fast: false
reversible: true

358110
type: KineticLaw
local parameters: 831259
local parameters: 831256
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx

831259
type: LocalParameter
units: 344978
value: 1.4E-17

831256
type: LocalParameter
units: 345062
value: 8.7498E-18

358098
type: SpeciesReference
stoichiometry: 1.0
species: 767056

358086
type: SpeciesReference
stoichiometry: 1.0
species: 766376

358074
type: SpeciesReference
stoichiometry: 1.0
species: 768756

774655
type: Reaction
kinetic law: 357097
product: 357085
product: 357073
reactant: 357061
fast: false
reversible: false

357097
type: KineticLaw
local parameters: 831163
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx

831163
type: LocalParameter
units: 344978
value: 1.7E-18

357085
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357073
type: SpeciesReference
stoichiometry: 1.0
species: 768576

357061
type: SpeciesReference
stoichiometry: 1.0
species: 766836

776455
type: Reaction
kinetic law: 361520
product: 361508
reactant: 361496
reactant: 361484
fast: false
reversible: true

361520
type: KineticLaw
local parameters: 831574
local parameters: 831571
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx

831574
type: LocalParameter
units: 344978
value: 7.2E-16

831571
type: LocalParameter
units: 345062
value: 2.011824E-17

361508
type: SpeciesReference
stoichiometry: 1.0
species: 768176

361496
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361484
type: SpeciesReference
stoichiometry: 1.0
species: 768776

775975
type: Reaction
kinetic law: 360360
product: 360348
reactant: 360336
reactant: 360324
fast: false
reversible: true

360360
type: KineticLaw
local parameters: 831466
local parameters: 831463
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx

831466
type: LocalParameter
units: 344978
value: 7.2E-16

831463
type: LocalParameter
units: 345062
value: 1.8106416E-16

360348
type: SpeciesReference
stoichiometry: 1.0
species: 767936

360336
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360324
type: SpeciesReference
stoichiometry: 1.0
species: 767416

773516
type: Reaction
kinetic law: 353710
product: 353698
product: 353686
reactant: 353674
fast: false
reversible: false

353710
type: KineticLaw
local parameters: 830850
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx

830850
type: LocalParameter
units: 344978
value: 5.0E-18

353698
type: SpeciesReference
stoichiometry: 1.0
species: 769136

353686
type: SpeciesReference
stoichiometry: 1.0
species: 768536

353674
type: SpeciesReference
stoichiometry: 1.0
species: 766036

771116
type: Reaction
kinetic law: 347881
product: 347869
product: 347857
reactant: 347845
fast: false
reversible: false

347881
type: KineticLaw
local parameters: 830307
notes: k3*PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

830307
type: LocalParameter
units: 344978
value: 2.25E-16

347869
type: SpeciesReference
stoichiometry: 1.0
species: 763797

347857
type: SpeciesReference
stoichiometry: 1.0
species: 764596

347845
type: SpeciesReference
stoichiometry: 1.0
species: 763836

775655
type: Reaction
kinetic law: 359587
product: 359575
reactant: 359563
reactant: 359551
fast: false
reversible: true

359587
type: KineticLaw
local parameters: 831394
local parameters: 831391
notes: k1*AMPAR_slash_A831_star_845_star__B*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx

831394
type: LocalParameter
units: 344978
value: 7.2E-16

831391
type: LocalParameter
units: 345062
value: 1.8106416E-16

359575
type: SpeciesReference
stoichiometry: 1.0
species: 767776

359563
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359551
type: SpeciesReference
stoichiometry: 1.0
species: 767356

775875
type: Reaction
kinetic law: 360119
product: 360107
product: 360095
reactant: 360083
fast: false
reversible: false

360119
type: KineticLaw
local parameters: 831442
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx

831442
type: LocalParameter
units: 344978
value: 1.8E-16

360107
type: SpeciesReference
stoichiometry: 1.0
species: 767636

360095
type: SpeciesReference
stoichiometry: 1.0
species: 767516

360083
type: SpeciesReference
stoichiometry: 1.0
species: 767876

773456
type: Reaction
kinetic law: 353566
product: 353554
reactant: 353542
reactant: 353530
fast: false
reversible: true

353566
type: KineticLaw
local parameters: 830838
local parameters: 830835
notes: k1*AMPAR_memb_slash_A845_star__B*actCaMKII_minus_PSD-k2*actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx

830838
type: LocalParameter
units: 344978
value: 2.0E-17

830835
type: LocalParameter
units: 345062
value: 2.77776E-19

353554
type: SpeciesReference
stoichiometry: 1.0
species: 766016

353542
type: SpeciesReference
stoichiometry: 1.0
species: 769136

353530
type: SpeciesReference
stoichiometry: 1.0
species: 768596

774695
type: Reaction
kinetic law: 357241
product: 357229
reactant: 357217
reactant: 357205
fast: false
reversible: true

357241
type: KineticLaw
local parameters: 831178
local parameters: 831175
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx

831178
type: LocalParameter
units: 344978
value: 1.4E-17

831175
type: LocalParameter
units: 345062
value: 8.7498E-18

357229
type: SpeciesReference
stoichiometry: 1.0
species: 766876

357217
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357205
type: SpeciesReference
stoichiometry: 1.0
species: 768736

774955
type: Reaction
kinetic law: 357869
product: 357857
product: 357845
reactant: 357833
fast: false
reversible: false

357869
type: KineticLaw
local parameters: 831235
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx

831235
type: LocalParameter
units: 344978
value: 3.5E-18

357857
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357845
type: SpeciesReference
stoichiometry: 1.0
species: 768676

357833
type: SpeciesReference
stoichiometry: 1.0
species: 766996

775115
type: Reaction
kinetic law: 358255
product: 358243
product: 358231
reactant: 358219
fast: false
reversible: false

358255
type: KineticLaw
local parameters: 831271
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx

831271
type: LocalParameter
units: 344978
value: 3.5E-18

358243
type: SpeciesReference
stoichiometry: 1.0
species: 766376

358231
type: SpeciesReference
stoichiometry: 1.0
species: 768616

358219
type: SpeciesReference
stoichiometry: 1.0
species: 767076

774456
type: Reaction
kinetic law: 356368
product: 356356
reactant: 356344
reactant: 356332
fast: false
reversible: true

356368
type: KineticLaw
local parameters: 831097
local parameters: 831094
notes: k1*AMPAR_memb_slash_A831_star__B*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx

831097
type: LocalParameter
units: 344978
value: 1.4E-17

831094
type: LocalParameter
units: 345062
value: 8.7498E-18

356356
type: SpeciesReference
stoichiometry: 1.0
species: 766696

356344
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356332
type: SpeciesReference
stoichiometry: 1.0
species: 768536

774676
type: Reaction
kinetic law: 357193
product: 357181
product: 357169
reactant: 357157
fast: false
reversible: false

357193
type: KineticLaw
local parameters: 831172
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx

831172
type: LocalParameter
units: 344978
value: 1.7E-18

357181
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357169
type: SpeciesReference
stoichiometry: 1.0
species: 768576

357157
type: SpeciesReference
stoichiometry: 1.0
species: 766856

770896
type: Reaction
kinetic law: 347399
product: 347387
reactant: 347375
reactant: 347363
fast: false
reversible: true

347399
type: KineticLaw
local parameters: 830247
local parameters: 830244
notes: kf*AMPAR_slash_A845_star__B831_star_845_star_*Anchor-kb*AMPAR_memb_slash_A845_star__B831_star_845_star_

830247
type: LocalParameter
units: 344978
value: 8.0E-20

830244
type: LocalParameter
units: 345062
value: 1.08E-19

347387
type: SpeciesReference
stoichiometry: 1.0
species: 768796

347375
type: SpeciesReference
stoichiometry: 1.0
species: 768436

347363
type: SpeciesReference
stoichiometry: 1.0
species: 767436

770456
type: Reaction
kinetic law: 346423
product: 346411
reactant: 346399
notes: Represents diffusion, from a volume of 9e-20 to 5e-18. Assuming neck dimensions of 0.1 x 0.1 microns, this works out to a diffusion const of about 270 um^2/sec, which is pretty conservative. It is what cAMP does in frog cilia.
fast: false
reversible: true

346423
type: KineticLaw
local parameters: 830115
local parameters: 830112
notes: kf*cAMP-kb*AC_slash_cAMP_in_dend

830115
type: LocalParameter
units: 344978
value: 2.7E-14

830112
type: LocalParameter
units: 344978
value: 2.7E-14

346411
type: SpeciesReference
stoichiometry: 1.0
species: 765716

346399
type: SpeciesReference
stoichiometry: 1.0
species: 763916

771716
type: Reaction
kinetic law: 349334
product: 349322
product: 349310
reactant: 349298
fast: false
reversible: false

349334
type: KineticLaw
local parameters: 830442
notes: k3*PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx

830442
type: LocalParameter
units: 344978
value: 5.4E-16

349322
type: SpeciesReference
stoichiometry: 1.0
species: 763956

349310
type: SpeciesReference
stoichiometry: 1.0
species: 767396

349298
type: SpeciesReference
stoichiometry: 1.0
species: 764136

777035
type: Reaction
kinetic law: 362922
product: 362910
product: 362898
reactant: 362886
fast: false
reversible: false

362922
type: KineticLaw
local parameters: 831703
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_act_autoph_slash_CaM_act_autoph_cplx

831703
type: LocalParameter
units: 344978
value: 2.0E-17

362910
type: SpeciesReference
stoichiometry: 1.0
species: 769456

362898
type: SpeciesReference
stoichiometry: 1.0
species: 765776

362886
type: SpeciesReference
stoichiometry: 1.0
species: 768496

765236
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 763757

774595
type: Reaction
kinetic law: 356857
product: 356845
reactant: 356833
reactant: 356821
fast: false
reversible: true

356857
type: KineticLaw
local parameters: 831142
local parameters: 831139
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx

831142
type: LocalParameter
units: 344978
value: 6.8E-18

831139
type: LocalParameter
units: 345062
value: 8.7498E-18

356845
type: SpeciesReference
stoichiometry: 1.0
species: 766796

356833
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356821
type: SpeciesReference
stoichiometry: 1.0
species: 768816

770196
type: Reaction
kinetic law: 345834
product: 345822
reactant: 345810
reactant: 345798
notes: going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1
fast: false
reversible: true

345834
type: KineticLaw
local parameters: 830037
local parameters: 830034
notes: kf*PP2B_slash_CaNAB*Ca^2-kb*PP2B_slash_CaNAB_minus_Ca2

830037
type: LocalParameter
units: 344978
value: 9.0E-17

830034
type: LocalParameter
units: 345014
value: 9.00720324E-13

345822
type: SpeciesReference
stoichiometry: 1.0
species: 765256

345810
type: SpeciesReference
stoichiometry: 2.0
species: 763936

345798
type: SpeciesReference
stoichiometry: 1.0
species: 765236

774096
type: Reaction
kinetic law: 355108
product: 355096
reactant: 355084
reactant: 355072
fast: false
reversible: true

355108
type: KineticLaw
local parameters: 830980
local parameters: 830977
notes: k1*CaMKII_star__star__star__minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

830980
type: LocalParameter
units: 344978
value: 8.0E-18

830977
type: LocalParameter
units: 345062
value: 4.99998E-18

355096
type: SpeciesReference
stoichiometry: 1.0
species: 766436

355084
type: SpeciesReference
stoichiometry: 1.0
species: 766376

355072
type: SpeciesReference
stoichiometry: 1.0
species: 765816

770056
type: Reaction
kinetic law: 345509
product: 345497
reactant: 345485
reactant: 345473
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true

345509
type: KineticLaw
local parameters: 829995
local parameters: 829992
notes: kf*CaM_slash_CaM_minus_PSD*Ca_minus_PSD^2-kb*CaM_minus_TR2_minus_Ca2_minus_PSD

829995
type: LocalParameter
units: 344978
value: 7.2E-16

829992
type: LocalParameter
units: 345014
value: 7.2E-16

345497
type: SpeciesReference
stoichiometry: 1.0
species: 765896

345485
type: SpeciesReference
stoichiometry: 2.0
species: 765956

345473
type: SpeciesReference
stoichiometry: 1.0
species: 764876

775715
type: Reaction
kinetic law: 359731
product: 359719
product: 359707
reactant: 359695
fast: false
reversible: false

359731
type: KineticLaw
local parameters: 831406
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx

831406
type: LocalParameter
units: 344978
value: 1.8E-16

359719
type: SpeciesReference
stoichiometry: 1.0
species: 767636

359707
type: SpeciesReference
stoichiometry: 1.0
species: 767516

359695
type: SpeciesReference
stoichiometry: 1.0
species: 767796

770096
type: Reaction
kinetic law: 345606
product: 345594
reactant: 345581
reactant: 345569
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true

345606
type: KineticLaw
local parameters: 830007
local parameters: 830004
notes: kf*CaM_minus_Ca3_minus_PSD*Ca_minus_PSD-kb*CaM_minus_Ca4_minus_PSD

830007
type: LocalParameter
units: 344978
value: 1.0E-16

830004
type: LocalParameter
units: 345062
value: 4.65012E-18

345594
type: SpeciesReference
stoichiometry: 1.0
species: 765936

345581
type: SpeciesReference
stoichiometry: 1.0
species: 765956

345569
type: SpeciesReference
stoichiometry: 1.0
species: 765916

775275
type: Reaction
kinetic law: 358653
product: 358641
product: 358629
product: 358617
reactant: 358605
fast: false
reversible: false

358653
type: KineticLaw
local parameters: 831307
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx

831307
type: LocalParameter
units: 344978
value: 3.15E-17

358641
type: SpeciesReference
stoichiometry: 1.0
species: 767136

358629
type: SpeciesReference
stoichiometry: 1.0
species: 764836

358617
type: SpeciesReference
stoichiometry: 1.0
species: 764796

358605
type: SpeciesReference
stoichiometry: 1.0
species: 767176

773396
type: Reaction
kinetic law: 353421
product: 353409
product: 353397
reactant: 353385
fast: false
reversible: false

353421
type: KineticLaw
local parameters: 830823
notes: k3*actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx

830823
type: LocalParameter
units: 344978
value: 5.0E-18

353409
type: SpeciesReference
stoichiometry: 1.0
species: 769136

353397
type: SpeciesReference
stoichiometry: 1.0
species: 768776

353385
type: SpeciesReference
stoichiometry: 1.0
species: 765976

776715
type: Reaction
kinetic law: 362149
product: 362137
product: 362125
reactant: 362113
fast: false
reversible: false

362149
type: KineticLaw
local parameters: 831631
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx

831631
type: LocalParameter
units: 344978
value: 1.8E-16

362137
type: SpeciesReference
stoichiometry: 1.0
species: 767636

362125
type: SpeciesReference
stoichiometry: 1.0
species: 768556

362113
type: SpeciesReference
stoichiometry: 1.0
species: 768296

776675
type: Reaction
kinetic law: 362051
product: 362039
product: 362027
reactant: 362015
fast: false
reversible: false

362051
type: KineticLaw
local parameters: 831622
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx

831622
type: LocalParameter
units: 344978
value: 1.8E-16

362039
type: SpeciesReference
stoichiometry: 1.0
species: 767636

362027
type: SpeciesReference
stoichiometry: 1.0
species: 768556

362015
type: SpeciesReference
stoichiometry: 1.0
species: 768276

772516
type: Reaction
kinetic law: 351284
product: 351272
product: 351259
reactant: 351247
fast: false
reversible: false

351284
type: KineticLaw
local parameters: 830622
notes: k3*PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx

830622
type: LocalParameter
units: 344978
value: 5.4E-16

351272
type: SpeciesReference
stoichiometry: 1.0
species: 763956

351259
type: SpeciesReference
stoichiometry: 1.0
species: 768816

351247
type: SpeciesReference
stoichiometry: 1.0
species: 764516

774455
type: Reaction
kinetic law: 356319
product: 356307
product: 356295
reactant: 356283
fast: false
reversible: false

356319
type: KineticLaw
local parameters: 831091
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx

831091
type: LocalParameter
units: 344978
value: 3.5E-18

356307
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356295
type: SpeciesReference
stoichiometry: 1.0
species: 768596

356283
type: SpeciesReference
stoichiometry: 1.0
species: 766676

776935
type: Reaction
kinetic law: 362682
product: 362670
reactant: 362658
reactant: 362646
fast: false
reversible: true

362682
type: KineticLaw
local parameters: 831682
local parameters: 831679
notes: k1*CaMKII_minus_thr286_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx

831682
type: LocalParameter
units: 344978
value: 2.4E-16

831679
type: LocalParameter
units: 345062
value: 9.375E-19

362670
type: SpeciesReference
stoichiometry: 1.0
species: 768456

362658
type: SpeciesReference
stoichiometry: 1.0
species: 769456

362646
type: SpeciesReference
stoichiometry: 1.0
species: 765776

770916
type: Reaction
kinetic law: 347447
product: 347435
reactant: 347423
reactant: 347411
fast: false
reversible: true

347447
type: KineticLaw
local parameters: 830253
local parameters: 830250
notes: kf*AMPAR_slash_A831_star_845_star__B845_star_*Anchor-kb*AMPAR_memb_slash_A831_star_845_star__B845_star_

830253
type: LocalParameter
units: 344978
value: 8.0E-20

830250
type: LocalParameter
units: 345062
value: 1.08E-19

347435
type: SpeciesReference
stoichiometry: 1.0
species: 768776

347423
type: SpeciesReference
stoichiometry: 1.0
species: 768436

347411
type: SpeciesReference
stoichiometry: 1.0
species: 767416

770396
type: Reaction
kinetic law: 346303
product: 346291
reactant: 346279
notes: Random rate.
fast: false
reversible: true

346303
type: KineticLaw
local parameters: 830097
local parameters: 830094
notes: kf*AC_slash_AC2_star_-kb*AC_slash_AC2

830097
type: LocalParameter
units: 344978
value: 0.0

830094
type: LocalParameter
units: 344978
value: 9.0E-18

346291
type: SpeciesReference
stoichiometry: 1.0
species: 765516

346279
type: SpeciesReference
stoichiometry: 1.0
species: 765496

772196
type: Reaction
kinetic law: 350507
product: 350495
product: 350483
reactant: 350471
fast: false
reversible: false

350507
type: KineticLaw
local parameters: 830550
notes: k3*PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx

830550
type: LocalParameter
units: 344978
value: 5.4E-16

350495
type: SpeciesReference
stoichiometry: 1.0
species: 763956

350483
type: SpeciesReference
stoichiometry: 1.0
species: 768776

350471
type: SpeciesReference
stoichiometry: 1.0
species: 764356

772896
type: Reaction
kinetic law: 352208
product: 352196
reactant: 352184
reactant: 352172
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true

352208
type: KineticLaw
local parameters: 830709
local parameters: 830706
notes: k1*PP1_PSD_slash_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx

830709
type: LocalParameter
units: 344978
value: 7.50006E-16

830706
type: LocalParameter
units: 345062
value: 6.4584E-18

352196
type: SpeciesReference
stoichiometry: 1.0
species: 765136

352184
type: SpeciesReference
stoichiometry: 1.0
species: 765076

352172
type: SpeciesReference
stoichiometry: 1.0
species: 766316

773256
type: Reaction
kinetic law: 353082
product: 353070
reactant: 353058
reactant: 353046
fast: false
reversible: true

353082
type: KineticLaw
local parameters: 830793
local parameters: 830790
notes: k1*CaMKII_minus_thr286_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx

830793
type: LocalParameter
units: 344978
value: 2.4E-16

830790
type: LocalParameter
units: 345062
value: 6.0E-19

353070
type: SpeciesReference
stoichiometry: 1.0
species: 765836

353058
type: SpeciesReference
stoichiometry: 1.0
species: 769096

353046
type: SpeciesReference
stoichiometry: 1.0
species: 765776

772536
type: Reaction
kinetic law: 351333
product: 351321
reactant: 351309
reactant: 351297
fast: false
reversible: true

351333
type: KineticLaw
local parameters: 830628
local parameters: 830625
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PKA_minus_active-k2*PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx

830628
type: LocalParameter
units: 344978
value: 2.16E-15

830625
type: LocalParameter
units: 345062
value: 3.999888E-17

351321
type: SpeciesReference
stoichiometry: 1.0
species: 764536

351309
type: SpeciesReference
stoichiometry: 1.0
species: 763956

351297
type: SpeciesReference
stoichiometry: 1.0
species: 768636

776355
type: Reaction
kinetic law: 361279
product: 361267
product: 361254
reactant: 361242
fast: false
reversible: false

361279
type: KineticLaw
local parameters: 831550
notes: k3*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx

831550
type: LocalParameter
units: 344978
value: 1.8E-16

361267
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361254
type: SpeciesReference
stoichiometry: 1.0
species: 768516

361242
type: SpeciesReference
stoichiometry: 1.0
species: 768116

774496
type: Reaction
kinetic law: 356569
product: 356557
reactant: 356545
reactant: 356533
fast: false
reversible: true

356569
type: KineticLaw
local parameters: 831115
local parameters: 831112
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx

831115
type: LocalParameter
units: 344978
value: 6.8E-18

831112
type: LocalParameter
units: 345062
value: 8.7498E-18

356557
type: SpeciesReference
stoichiometry: 1.0
species: 766736

356545
type: SpeciesReference
stoichiometry: 1.0
species: 766376

356533
type: SpeciesReference
stoichiometry: 1.0
species: 768796

776375
type: Reaction
kinetic law: 361327
product: 361315
reactant: 361303
reactant: 361291
fast: false
reversible: true

361327
type: KineticLaw
local parameters: 831556
local parameters: 831553
notes: k1*AMPAR_memb_slash_A845_star__B*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx

831556
type: LocalParameter
units: 344978
value: 7.2E-16

831553
type: LocalParameter
units: 345062
value: 2.011824E-17

361315
type: SpeciesReference
stoichiometry: 1.0
species: 768136

361303
type: SpeciesReference
stoichiometry: 1.0
species: 767636

361291
type: SpeciesReference
stoichiometry: 1.0
species: 768596

774715
type: Reaction
kinetic law: 357290
product: 357278
product: 357266
reactant: 357253
fast: false
reversible: false

357290
type: KineticLaw
local parameters: 831181
notes: k3*PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx

831181
type: LocalParameter
units: 344978
value: 3.5E-18

357278
type: SpeciesReference
stoichiometry: 1.0
species: 766376

357266
type: SpeciesReference
stoichiometry: 1.0
species: 768656

357253
type: SpeciesReference
stoichiometry: 1.0
species: 766876