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321979
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notes: k3*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx

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notes: Rates set by the translocation experiments of Shen and Meyer, Science 1999.
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319983
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notes: kf*CaMKII_minus_PSD-kb*CaMKII_slash_CaMKII*NMDAR

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713821
type: Reaction
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product: 322244
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322268
type: KineticLaw
local parameters: 037053
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx

037053
type: LocalParameter
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714041
type: Reaction
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fast: false
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322800
type: KineticLaw
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notes: k1*CaMKII_star__star__star__minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

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value: 8.0E-18

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713981
type: Reaction
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fast: false
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322655
type: KineticLaw
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notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

037073
type: LocalParameter
units: 319057
value: 2.0E-18

322642
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713801
type: Reaction
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fast: false
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322220
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notes: k1*CaMKII_minus_CaM_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx

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value: 2.0E-17

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713281
type: Reaction
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reactant: 320919
notes: #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
fast: false
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notes: k1*PP1_slash_I1*PKA_minus_active-k2*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx

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322606
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notes: k1*CaMKII_star__star__star__minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

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notes: kf*Ca_control_cyt-kb*Ca

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value: 9.0E-15

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value: 9.0E-15

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notes: kf*basal_CaMKII_PSD_control-kb*basal_CaMKII_PSD

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value: 1.0E-17

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value: 1.0E-17

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713261
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product: 320883
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fast: false
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notes: k3*PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

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units: 319057
value: 2.25E-16

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fast: false
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322076
type: KineticLaw
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notes: k3*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx

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value: 3.06E-18

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reactant: 319800
fast: false
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notes: kf*CaMKII_minus_PSD*CaM_minus_Ca4_minus_PSD-kb*CaMKII_minus_CaM_minus_PSD

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value: 4.99998E-16

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713001
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fast: false
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notes: kf*CaMKII_minus_CaM_minus_PSD-kb*CaM_minus_Ca4_minus_PSD*CaMKII_minus_PSD

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value: 0.0

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value: 5.0E-17

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fast: false
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notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx

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type: LocalParameter
units: 319057
value: 1.8E-16

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713041
type: Reaction
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product: 320371
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fast: false
reversible: true

320384
type: KineticLaw
local parameters: 036962
local parameters: 036961
notes: kf*Ca_control_PSD-kb*Ca_minus_PSD

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type: LocalParameter
units: 319057
value: 1.0E-15

036961
type: LocalParameter
units: 319057
value: 1.0E-15

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initial concentration: 0.08
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type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
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in compartment: 710661

713521
type: Reaction
kinetic law: 321534
product: 321522
reactant: 321510
reactant: 321498
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true

321534
type: KineticLaw
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local parameters: 037015
notes: k1*PP1_slash_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx

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type: LocalParameter
units: 319057
value: 7.50006E-16

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type: LocalParameter
units: 319142
value: 5.81256E-17

321522
type: SpeciesReference
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species: 711281

711281
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.99333333333333E-6
initial amount: NaN
in compartment: 710641

321510
type: SpeciesReference
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species: 711261

321498
type: SpeciesReference
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species: 711201

713661
type: Reaction
kinetic law: 321883
product: 321871
product: 321859
reactant: 321847
fast: false
reversible: false

321883
type: KineticLaw
local parameters: 037033
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx

037033
type: LocalParameter
units: 319057
value: 1.8E-16

321871
type: SpeciesReference
stoichiometry: 1.0
species: 711261

321859
type: SpeciesReference
stoichiometry: 1.0
species: 711761

711761
type: Species
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type: Species
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initial amount: NaN
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type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 710661

711861
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661

712901
type: Reaction
kinetic law: 320079
product: 320067
reactant: 320055
reactant: 320043
notes: Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
fast: false
reversible: true

320079
type: KineticLaw
local parameters: 036947
local parameters: 036946
notes: kf*CaMKII_minus_thr286_minus_PSD*CaM_minus_Ca4_minus_PSD-kb*CaMKII_minus_thr286_minus_CaM_minus_PSD

036947
type: LocalParameter
units: 319057
value: 1.0E-18

036946
type: LocalParameter
units: 319142
value: 1.00002E-14

320067
type: SpeciesReference
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species: 711461

320055
type: SpeciesReference
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type: SpeciesReference
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711501
type: Species
constant: false
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712621
type: Reaction
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product: 319385
reactant: 319373
reactant: 319361
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true

319397
type: KineticLaw
local parameters: 036915
local parameters: 036914
notes: kf*CaM_minus_TR2_minus_Ca2*Ca-kb*CaM_minus_Ca3

036915
type: LocalParameter
units: 319057
value: 9.0E-16

036914
type: LocalParameter
units: 319142
value: 3.2400162E-16

319385
type: SpeciesReference
stoichiometry: 1.0
species: 711141

711141
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641

319373
type: SpeciesReference
stoichiometry: 1.0
species: 710821

319361
type: SpeciesReference
stoichiometry: 1.0
species: 711161

711161
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641

711641
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00254583333333333
initial amount: NaN
in compartment: 710661

712661
type: Reaction
kinetic law: 319495
product: 319482
reactant: 319470
reactant: 319458
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true

319495
type: KineticLaw
local parameters: 036919
local parameters: 036918
notes: kf*CaM_minus_TR2_minus_Ca2_minus_PSD*Ca_minus_PSD-kb*CaM_minus_Ca3_minus_PSD

036919
type: LocalParameter
units: 319057
value: 1.0E-16

036918
type: LocalParameter
units: 319142
value: 3.6E-17

319482
type: SpeciesReference
stoichiometry: 1.0
species: 711641

319470
type: SpeciesReference
stoichiometry: 1.0
species: 711681

319458
type: SpeciesReference
stoichiometry: 1.0
species: 711621

711621
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661

711721
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661

713081
type: Reaction
kinetic law: 320468
product: 320456
reactant: 320444
reactant: 320432
fast: false
reversible: true

320468
type: KineticLaw
local parameters: 036966
local parameters: 036965
notes: k1*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

036966
type: LocalParameter
units: 319057
value: 9.0E-16

036965
type: LocalParameter
units: 319142
value: 2.2062942E-16

320456
type: SpeciesReference
stoichiometry: 1.0
species: 710721

320444
type: SpeciesReference
stoichiometry: 1.0
species: 710701

320432
type: SpeciesReference
stoichiometry: 1.0
species: 710941

711041
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.90055555555556E-8
initial amount: NaN
in compartment: 710641

712121
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 710641

713721
type: Reaction
kinetic law: 322027
product: 322015
reactant: 322003
reactant: 321991
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true

322027
type: KineticLaw
local parameters: 037042
local parameters: 037040
notes: k1*PP1_PSD_slash_I1_star_*CaNAB_minus_Ca4-k2*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx

037042
type: LocalParameter
units: 319057
value: 1.224E-17

037040
type: LocalParameter
units: 319142
value: 3.420036E-19

322015
type: SpeciesReference
stoichiometry: 1.0
species: 711401

322003
type: SpeciesReference
stoichiometry: 1.0
species: 711361

321991
type: SpeciesReference
stoichiometry: 1.0
species: 711721

714281
type: Reaction
kinetic law: 323376
product: 323364
reactant: 323352
reactant: 323340
fast: false
reversible: true

323376
type: KineticLaw
local parameters: 037112
local parameters: 037110
notes: k1*CaMKII_minus_CaM_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx

037112
type: LocalParameter
units: 319057
value: 2.0E-17

037110
type: LocalParameter
units: 319142
value: 7.8126E-20

323364
type: SpeciesReference
stoichiometry: 1.0
species: 712061

712061
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661

323352
type: SpeciesReference
stoichiometry: 1.0
species: 712361

712361
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661

323340
type: SpeciesReference
stoichiometry: 1.0
species: 711481

713201
type: Reaction
kinetic law: 320761
product: 320749
reactant: 320737
reactant: 320725
fast: false
reversible: true

320761
type: KineticLaw
local parameters: 036977
local parameters: 036975
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

036977
type: LocalParameter
units: 319057
value: 9.0E-16

036975
type: LocalParameter
units: 319142
value: 2.2062942E-16

320749
type: SpeciesReference
stoichiometry: 1.0
species: 710781

710781
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641

320737
type: SpeciesReference
stoichiometry: 1.0
species: 710701

320725
type: SpeciesReference
stoichiometry: 1.0
species: 710961

710961
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641

714061
type: Reaction
kinetic law: 322848
product: 322836
product: 322824
reactant: 322812
fast: false
reversible: false

322848
type: KineticLaw
local parameters: 037083
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

037083
type: LocalParameter
units: 319057
value: 2.0E-18

322836
type: SpeciesReference
stoichiometry: 1.0
species: 711781

322824
type: SpeciesReference
stoichiometry: 1.0
species: 711501

322812
type: SpeciesReference
stoichiometry: 1.0
species: 711881

712981
type: Reaction
kinetic law: 320261
product: 320249
reactant: 320237
reactant: 320225
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true

320261
type: KineticLaw
local parameters: 036956
local parameters: 036955
notes: kf*CaM_minus_Ca3*Ca-kb*CaM_minus_Ca4

036956
type: LocalParameter
units: 319057
value: 9.0E-16

036955
type: LocalParameter
units: 319142
value: 4.1849946E-17

320249
type: SpeciesReference
stoichiometry: 1.0
species: 710681

710681
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641

320237
type: SpeciesReference
stoichiometry: 1.0
species: 710821

320225
type: SpeciesReference
stoichiometry: 1.0
species: 711141

711821
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661

712081
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661

713241
type: Reaction
kinetic law: 320859
product: 320846
reactant: 320833
reactant: 320821
fast: false
reversible: true

320859
type: KineticLaw
local parameters: 036982
local parameters: 036980
notes: k1*CaMKII_slash_CaMK_minus_thr305*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

036982
type: LocalParameter
units: 319057
value: 9.0E-16

036980
type: LocalParameter
units: 319142
value: 2.2062942E-16

320846
type: SpeciesReference
stoichiometry: 1.0
species: 710801

320833
type: SpeciesReference
stoichiometry: 1.0
species: 710701

320821
type: SpeciesReference
stoichiometry: 1.0
species: 711081

712321
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 22.0
initial amount: NaN
in compartment: 710641

712001
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641

713641
type: Reaction
kinetic law: 321835
product: 321823
reactant: 321811
reactant: 321798
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true

321835
type: KineticLaw
local parameters: 037032
local parameters: 037030
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx

037032
type: LocalParameter
units: 319057
value: 7.50006E-16

037030
type: LocalParameter
units: 319142
value: 6.4584E-18

321823
type: SpeciesReference
stoichiometry: 1.0
species: 711341

321811
type: SpeciesReference
stoichiometry: 1.0
species: 711261

321798
type: SpeciesReference
stoichiometry: 1.0
species: 711741

711741
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661

713221
type: Reaction
kinetic law: 320809
product: 320797
product: 320785
reactant: 320773
fast: false
reversible: false

320809
type: KineticLaw
local parameters: 036978
notes: k3*PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

036978
type: LocalParameter
units: 319057
value: 2.25E-16

320797
type: SpeciesReference
stoichiometry: 1.0
species: 710701

320785
type: SpeciesReference
stoichiometry: 1.0
species: 711081

320773
type: SpeciesReference
stoichiometry: 1.0
species: 710781

713421
type: Reaction
kinetic law: 321294
product: 321282
product: 321270
reactant: 321257
fast: false
reversible: false

321294
type: KineticLaw
local parameters: 037003
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx

037003
type: LocalParameter
units: 319057
value: 4.5E-17

321282
type: SpeciesReference
stoichiometry: 1.0
species: 712201

712201
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641

321270
type: SpeciesReference
stoichiometry: 1.0
species: 710941

321257
type: SpeciesReference
stoichiometry: 1.0
species: 711021

711021
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.44537037037037E-8
initial amount: NaN
in compartment: 710641

712841
type: Reaction
kinetic law: 319935
product: 319923
reactant: 319911
reactant: 319899
notes: Same as for transloc_1
fast: false
reversible: true

319935
type: KineticLaw
local parameters: 036941
local parameters: 036940
notes: kf*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*NMDAR-kb*CaMKII_minus_thr286_minus_CaM_minus_PSD

036941
type: LocalParameter
units: 319057
value: 0.0

036940
type: LocalParameter
units: 319142
value: 1.08E-20

319923
type: SpeciesReference
stoichiometry: 1.0
species: 711461

319911
type: SpeciesReference
stoichiometry: 1.0
species: 711901

319899
type: SpeciesReference
stoichiometry: 1.0
species: 710941

712761
type: Reaction
kinetic law: 319739
product: 319727
reactant: 319714
reactant: 319701
notes: going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1
fast: false
reversible: true

319739
type: KineticLaw
local parameters: 036933
local parameters: 036932
notes: kf*PP2B_slash_CaNAB*Ca^2-kb*PP2B_slash_CaNAB_minus_Ca2

036933
type: LocalParameter
units: 319057
value: 9.0E-17

036932
type: LocalParameter
units: 319093
value: 9.00720324E-13

319129
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

319117
type: SBMLUnit
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE

319105
type: SBMLUnit
exponent: 3.0
scale: 0
multipler: 1.0
kind: LITRE

319727
type: SpeciesReference
stoichiometry: 1.0
species: 711441

711441
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641

319714
type: SpeciesReference
stoichiometry: 2.0
species: 710821

319701
type: SpeciesReference
stoichiometry: 1.0
species: 711421

712821
type: Reaction
kinetic law: 319887
product: 319874
reactant: 319861
reactant: 319848
notes: Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers
fast: false
reversible: true

319887
type: KineticLaw
local parameters: 036939
local parameters: 036938
notes: kf*CaMKII_slash_CaMKII_minus_CaM*NMDAR-kb*CaMKII_minus_CaM_minus_PSD

036939
type: LocalParameter
units: 319057
value: 0.0

036938
type: LocalParameter
units: 319142
value: 1.08E-20

319874
type: SpeciesReference
stoichiometry: 1.0
species: 711481

319861
type: SpeciesReference
stoichiometry: 1.0
species: 711901

319848
type: SpeciesReference
stoichiometry: 1.0
species: 710921

713441
type: Reaction
kinetic law: 321342
product: 321330
reactant: 321318
reactant: 321306
notes: See Hanson and Schulman again, for afterburst rates of phosph.
fast: false
reversible: true

321342
type: KineticLaw
local parameters: 037007
local parameters: 037005
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx

037007
type: LocalParameter
units: 319057
value: 2.16E-15

037005
type: LocalParameter
units: 319142
value: 7.714278E-18

321330
type: SpeciesReference
stoichiometry: 1.0
species: 711041

321318
type: SpeciesReference
stoichiometry: 1.0
species: 712221

321306
type: SpeciesReference
stoichiometry: 1.0
species: 710981

712741
type: Reaction
kinetic law: 319689
product: 319677
reactant: 319664
reactant: 319652
notes: This process is probably much more complicated and involves CaM. However, as I can\'t find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11
fast: false
reversible: true

319689
type: KineticLaw
local parameters: 036931
local parameters: 036930
notes: kf*Ca^2*PP2B_slash_CaNAB_minus_Ca2-kb*CaNAB_minus_Ca4

036931
type: LocalParameter
units: 319057
value: 9.0E-17

036930
type: LocalParameter
units: 319093
value: 3.24008424E-16

319677
type: SpeciesReference
stoichiometry: 1.0
species: 711361

319664
type: SpeciesReference
stoichiometry: 1.0
species: 711441

319652
type: SpeciesReference
stoichiometry: 2.0
species: 710821

711101
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 710641

712641
type: Reaction
kinetic law: 319446
product: 319434
reactant: 319422
reactant: 319410
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true

319446
type: KineticLaw
local parameters: 036917
local parameters: 036916
notes: kf*CaM_slash_CaM_minus_PSD*Ca_minus_PSD^2-kb*CaM_minus_TR2_minus_Ca2_minus_PSD

036917
type: LocalParameter
units: 319057
value: 7.2E-16

036916
type: LocalParameter
units: 319093
value: 7.2E-16

319434
type: SpeciesReference
stoichiometry: 1.0
species: 711621

319422
type: SpeciesReference
stoichiometry: 2.0
species: 711681

319410
type: SpeciesReference
stoichiometry: 1.0
species: 711121

711121
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 710661

711561
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661

713181
type: Reaction
kinetic law: 320713
product: 320701
product: 320689
reactant: 320677
fast: false
reversible: false

320713
type: KineticLaw
local parameters: 036973
notes: k3*PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

036973
type: LocalParameter
units: 319057
value: 2.25E-16

320701
type: SpeciesReference
stoichiometry: 1.0
species: 710701

320689
type: SpeciesReference
stoichiometry: 1.0
species: 710981

320677
type: SpeciesReference
stoichiometry: 1.0
species: 710761

710761
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641

713161
type: Reaction
kinetic law: 320665
product: 320653
reactant: 320641
reactant: 320628
fast: false
reversible: true

320665
type: KineticLaw
local parameters: 036972
local parameters: 036971
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

036972
type: LocalParameter
units: 319057
value: 9.0E-16

036971
type: LocalParameter
units: 319142
value: 2.2062942E-16

320653
type: SpeciesReference
stoichiometry: 1.0
species: 710761

320641
type: SpeciesReference
stoichiometry: 1.0
species: 710701

320628
type: SpeciesReference
stoichiometry: 1.0
species: 710961

713861
type: Reaction
kinetic law: 322365
product: 322352
product: 322340
reactant: 322328
fast: false
reversible: false

322365
type: KineticLaw
local parameters: 037058
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_autoph_slash_auton_minus_autoph_cplx

037058
type: LocalParameter
units: 319057
value: 2.0E-17

322352
type: SpeciesReference
stoichiometry: 1.0
species: 712241

322340
type: SpeciesReference
stoichiometry: 1.0
species: 711501

322328
type: SpeciesReference
stoichiometry: 1.0
species: 711601

711601
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661

713841
type: Reaction
kinetic law: 322316
product: 322304
reactant: 322292
reactant: 322280
fast: false
reversible: true

322316
type: KineticLaw
local parameters: 037057
local parameters: 037055
notes: k1*CaMKII_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_autoph_slash_auton_minus_autoph_cplx

037057
type: LocalParameter
units: 319057
value: 8.0E-17

037055
type: LocalParameter
units: 319142
value: 1.99998E-19

322304
type: SpeciesReference
stoichiometry: 1.0
species: 711601

322292
type: SpeciesReference
stoichiometry: 1.0
species: 712241

322280
type: SpeciesReference
stoichiometry: 1.0
species: 711521

713621
type: Reaction
kinetic law: 321785
product: 321772
product: 321759
reactant: 321746
fast: false
reversible: false

321785
type: KineticLaw
local parameters: 037028
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx

037028
type: LocalParameter
units: 319057
value: 1.8E-16

321772
type: SpeciesReference
stoichiometry: 1.0
species: 711261

321759
type: SpeciesReference
stoichiometry: 1.0
species: 711701

321746
type: SpeciesReference
stoichiometry: 1.0
species: 711321

711321
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.21555555555556E-7
initial amount: NaN
in compartment: 710641

714241
type: Reaction
kinetic law: 323280
product: 323268
reactant: 323256
reactant: 323244
fast: false
reversible: true

323280
type: KineticLaw
local parameters: 037107
local parameters: 037105
notes: k1*CaMKII_minus_thr286_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx

037107
type: LocalParameter
units: 319057
value: 2.4E-16

037105
type: LocalParameter
units: 319142
value: 9.375E-19

323268
type: SpeciesReference
stoichiometry: 1.0
species: 712041

712041
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661

323256
type: SpeciesReference
stoichiometry: 1.0
species: 712361

323244
type: SpeciesReference
stoichiometry: 1.0
species: 711501

712261
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661

713461
type: Reaction
kinetic law: 321390
product: 321378
product: 321366
reactant: 321354
fast: false
reversible: false

321390
type: KineticLaw
local parameters: 037008
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx

037008
type: LocalParameter
units: 319057
value: 5.4E-16

321378
type: SpeciesReference
stoichiometry: 1.0
species: 712221

321366
type: SpeciesReference
stoichiometry: 1.0
species: 710961

321354
type: SpeciesReference
stoichiometry: 1.0
species: 711041

713401
type: Reaction
kinetic law: 321245
product: 321233
reactant: 321220
reactant: 321208
fast: false
reversible: true

321245
type: KineticLaw
local parameters: 037002
local parameters: 037000
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx

037002
type: LocalParameter
units: 319057
value: 1.8E-16

037000
type: LocalParameter
units: 319142
value: 9.91197E-19

321233
type: SpeciesReference
stoichiometry: 1.0
species: 711021

321220
type: SpeciesReference
stoichiometry: 1.0
species: 712201

321208
type: SpeciesReference
stoichiometry: 1.0
species: 710921

712581
type: Reaction
kinetic law: 319301
product: 319288
reactant: 319276
reactant: 319264
notes: Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
fast: false
reversible: true

319301
type: KineticLaw
local parameters: 036911
local parameters: 036909
notes: kf*CaMKII_slash_CaMKII_minus_thr286*CaM_minus_Ca4-kb*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM

036911
type: LocalParameter
units: 319057
value: 9.0E-18

036909
type: LocalParameter
units: 319142
value: 9.001692E-14

319288
type: SpeciesReference
stoichiometry: 1.0
species: 710941

319276
type: SpeciesReference
stoichiometry: 1.0
species: 710681

319264
type: SpeciesReference
stoichiometry: 1.0
species: 710981

714141
type: Reaction
kinetic law: 323040
product: 323028
product: 323016
reactant: 323004
fast: false
reversible: false

323040
type: KineticLaw
local parameters: 037093
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx

037093
type: LocalParameter
units: 319057
value: 3.06E-17

323028
type: SpeciesReference
stoichiometry: 1.0
species: 711921

323016
type: SpeciesReference
stoichiometry: 1.0
species: 711241

323004
type: SpeciesReference
stoichiometry: 1.0
species: 711961

711961
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641

712941
type: Reaction
kinetic law: 320164
product: 320152
product: 320140
reactant: 320128
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true

320164
type: KineticLaw
local parameters: 036952
local parameters: 036951
notes: kf*PP1_PSD_slash_PP1_minus_I1-kb*PP1_PSD_slash_I1*PP1_minus_active_PSD

036952
type: LocalParameter
units: 319142
value: 0.0

036951
type: LocalParameter
units: 319057
value: 1.0E-17

320152
type: SpeciesReference
stoichiometry: 1.0
species: 711781

320140
type: SpeciesReference
stoichiometry: 1.0
species: 711701

320128
type: SpeciesReference
stoichiometry: 1.0
species: 711761

711801
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710661

713941
type: Reaction
kinetic law: 322558
product: 322546
product: 322534
reactant: 322522
fast: false
reversible: false

322558
type: KineticLaw
local parameters: 037068
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

037068
type: LocalParameter
units: 319057
value: 2.0E-18

322546
type: SpeciesReference
stoichiometry: 1.0
species: 711781

322534
type: SpeciesReference
stoichiometry: 1.0
species: 711521

322522
type: SpeciesReference
stoichiometry: 1.0
species: 711821

712561
type: Reaction
kinetic law: 319252
product: 319240
reactant: 319227
reactant: 319215
notes: This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
fast: false
reversible: true

319252
type: KineticLaw
local parameters: 036908
local parameters: 036907
notes: kf*CaM_minus_Ca4*CaMKII_slash_CaMKII-kb*CaMKII_slash_CaMKII_minus_CaM

036908
type: LocalParameter
units: 319057
value: 4.5E-16

036907
type: LocalParameter
units: 319142
value: 4.4999712E-15

319240
type: SpeciesReference
stoichiometry: 1.0
species: 710921

319227
type: SpeciesReference
stoichiometry: 1.0
species: 710901

319215
type: SpeciesReference
stoichiometry: 1.0
species: 710681

713921
type: Reaction
kinetic law: 322510
product: 322498
reactant: 322486
reactant: 322474
fast: false
reversible: true

322510
type: KineticLaw
local parameters: 037067
local parameters: 037065
notes: k1*CaMKII_minus_thr286_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

037067
type: LocalParameter
units: 319057
value: 8.0E-18

037065
type: LocalParameter
units: 319142
value: 4.99998E-18

322498
type: SpeciesReference
stoichiometry: 1.0
species: 711821

322486
type: SpeciesReference
stoichiometry: 1.0
species: 711781

322474
type: SpeciesReference
stoichiometry: 1.0
species: 711501

711981
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641

713141
type: Reaction
kinetic law: 320616
product: 320604
product: 320592
reactant: 320579
fast: false
reversible: false

320616
type: KineticLaw
local parameters: 036970
notes: k3*PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

036970
type: LocalParameter
units: 319057
value: 2.25E-16

320604
type: SpeciesReference
stoichiometry: 1.0
species: 710701

320592
type: SpeciesReference
stoichiometry: 1.0
species: 710901

320579
type: SpeciesReference
stoichiometry: 1.0
species: 710741

712681
type: Reaction
kinetic law: 319543
product: 319531
reactant: 319519
reactant: 319507
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true

319543
type: KineticLaw
local parameters: 036923
local parameters: 036921
notes: kf*CaM_minus_Ca3_minus_PSD*Ca_minus_PSD-kb*CaM_minus_Ca4_minus_PSD

036923
type: LocalParameter
units: 319057
value: 1.0E-16

036921
type: LocalParameter
units: 319142
value: 4.65012E-18

319531
type: SpeciesReference
stoichiometry: 1.0
species: 711661

319519
type: SpeciesReference
stoichiometry: 1.0
species: 711681

319507
type: SpeciesReference
stoichiometry: 1.0
species: 711641

714181
type: Reaction
kinetic law: 323136
product: 323124
product: 323112
reactant: 323100
fast: false
reversible: false

323136
type: KineticLaw
local parameters: 037098
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx

037098
type: LocalParameter
units: 319057
value: 3.06E-17

323124
type: SpeciesReference
stoichiometry: 1.0
species: 711921

323112
type: SpeciesReference
stoichiometry: 1.0
species: 711701

323100
type: SpeciesReference
stoichiometry: 1.0
species: 711981

713601
type: Reaction
kinetic law: 321733
product: 321720
reactant: 321706
reactant: 321693
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true

321733
type: KineticLaw
local parameters: 037027
local parameters: 037025
notes: k1*PP1_PSD_slash_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx

037027
type: LocalParameter
units: 319057
value: 7.50006E-16

037025
type: LocalParameter
units: 319142
value: 6.4584E-18

321720
type: SpeciesReference
stoichiometry: 1.0
species: 711321

321706
type: SpeciesReference
stoichiometry: 1.0
species: 711261

321693
type: SpeciesReference
stoichiometry: 1.0
species: 711721

713121
type: Reaction
kinetic law: 320567
product: 320554
reactant: 320542
reactant: 320530
fast: false
reversible: true

320567
type: KineticLaw
local parameters: 036969
local parameters: 036968
notes: k1*CaMKII_slash_CaMKII_minus_thr286*PP1_minus_active-k2*PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

036969
type: LocalParameter
units: 319057
value: 9.0E-16

036968
type: LocalParameter
units: 319142
value: 2.2062942E-16

320554
type: SpeciesReference
stoichiometry: 1.0
species: 710741

320542
type: SpeciesReference
stoichiometry: 1.0
species: 710701

320530
type: SpeciesReference
stoichiometry: 1.0
species: 710981

713381
type: Reaction
kinetic law: 321196
product: 321183
product: 321171
reactant: 321159
fast: false
reversible: false

321196
type: KineticLaw
local parameters: 036998
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx

036998
type: LocalParameter
units: 319057
value: 5.4E-16

321183
type: SpeciesReference
stoichiometry: 1.0
species: 712201

321171
type: SpeciesReference
stoichiometry: 1.0
species: 710961

321159
type: SpeciesReference
stoichiometry: 1.0
species: 711001

711001
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6.3262962962963E-11
initial amount: NaN
in compartment: 710641

711221
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641

713781
type: Reaction
kinetic law: 322172
product: 322160
product: 322148
reactant: 322136
fast: false
reversible: false

322172
type: KineticLaw
local parameters: 037048
notes: k3*tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx

037048
type: LocalParameter
units: 319057
value: 6.0E-17

322160
type: SpeciesReference
stoichiometry: 1.0
species: 712241

322148
type: SpeciesReference
stoichiometry: 1.0
species: 711541

322136
type: SpeciesReference
stoichiometry: 1.0
species: 711561

319203
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

712701
type: Reaction
kinetic law: 319591
product: 319579
reactant: 319567
reactant: 319555
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true

319591
type: KineticLaw
local parameters: 036927
local parameters: 036925
notes: kf*PP1_slash_I1_star_*PP1_minus_active-kb*PP1_slash_PP1_minus_I1_star_

036927
type: LocalParameter
units: 319057
value: 9.0E-18

036925
type: LocalParameter
units: 319142
value: 4.4998254E-14

319579
type: SpeciesReference
stoichiometry: 1.0
species: 711221

319567
type: SpeciesReference
stoichiometry: 1.0
species: 710701

319555
type: SpeciesReference
stoichiometry: 1.0
species: 711201

714341
type: Reaction
kinetic law: 323523
product: 323511
product: 323499
reactant: 323487
fast: false
reversible: false

323523
type: KineticLaw
local parameters: 037118
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_act_autoph_slash_CaM_act_autoph_cplx

037118
type: LocalParameter
units: 319057
value: 2.0E-17

323511
type: SpeciesReference
stoichiometry: 1.0
species: 712361

323499
type: SpeciesReference
stoichiometry: 1.0
species: 711501

323487
type: SpeciesReference
stoichiometry: 1.0
species: 712081

714121
type: Reaction
kinetic law: 322992
product: 322980
reactant: 322968
reactant: 322956
fast: false
reversible: true

322992
type: KineticLaw
local parameters: 037092
local parameters: 037090
notes: k1*PP1_slash_PP1_minus_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx

037092
type: LocalParameter
units: 319057
value: 1.224E-16

037090
type: LocalParameter
units: 319142
value: 3.0779838E-17

322980
type: SpeciesReference
stoichiometry: 1.0
species: 711961

322968
type: SpeciesReference
stoichiometry: 1.0
species: 711921

322956
type: SpeciesReference
stoichiometry: 1.0
species: 711221

713881
type: Reaction
kinetic law: 322413
product: 322401
reactant: 322389
reactant: 322377
fast: false
reversible: true

322413
type: KineticLaw
local parameters: 037062
local parameters: 037060
notes: k1*CaMKII_minus_thr286_minus_CaM_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

037062
type: LocalParameter
units: 319057
value: 8.0E-18

037060
type: LocalParameter
units: 319142
value: 4.99998E-18

322401
type: SpeciesReference
stoichiometry: 1.0
species: 711801

322389
type: SpeciesReference
stoichiometry: 1.0
species: 711781

322377
type: SpeciesReference
stoichiometry: 1.0
species: 711461

714321
type: Reaction
kinetic law: 323475
product: 323463
reactant: 323451
reactant: 323438
fast: false
reversible: true

323475
type: KineticLaw
local parameters: 037117
local parameters: 037115
notes: k1*CaMKII_minus_PSD*tot_minus_CaM_minus_CaMKII_minus_PSD-k2*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_act_autoph_slash_CaM_act_autoph_cplx

037117
type: LocalParameter
units: 319057
value: 8.0E-17

037115
type: LocalParameter
units: 319142
value: 3.12498E-19

323463
type: SpeciesReference
stoichiometry: 1.0
species: 712081

323451
type: SpeciesReference
stoichiometry: 1.0
species: 712361

323438
type: SpeciesReference
stoichiometry: 1.0
species: 711521

714161
type: Reaction
kinetic law: 323088
product: 323076
reactant: 323064
reactant: 323052
fast: false
reversible: true

323088
type: KineticLaw
local parameters: 037097
local parameters: 037095
notes: k1*PP1_PSD_slash_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx

037097
type: LocalParameter
units: 319057
value: 1.224E-16

037095
type: LocalParameter
units: 319142
value: 3.420036E-18

323076
type: SpeciesReference
stoichiometry: 1.0
species: 711981

323064
type: SpeciesReference
stoichiometry: 1.0
species: 711921

323052
type: SpeciesReference
stoichiometry: 1.0
species: 711721

714101
type: Reaction
kinetic law: 322944
product: 322932
product: 322920
reactant: 322908
fast: false
reversible: false

322944
type: KineticLaw
local parameters: 037088
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx

037088
type: LocalParameter
units: 319057
value: 3.06E-17

322932
type: SpeciesReference
stoichiometry: 1.0
species: 711921

322920
type: SpeciesReference
stoichiometry: 1.0
species: 711181

322908
type: SpeciesReference
stoichiometry: 1.0
species: 711941

711941
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 710641

714021
type: Reaction
kinetic law: 322752
product: 322740
product: 322728
reactant: 322716
fast: false
reversible: false

322752
type: KineticLaw
local parameters: 037078
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

037078
type: LocalParameter
units: 319057
value: 2.0E-18

322740
type: SpeciesReference
stoichiometry: 1.0
species: 711781

322728
type: SpeciesReference
stoichiometry: 1.0
species: 711521

322716
type: SpeciesReference
stoichiometry: 1.0
species: 711861

713321
type: Reaction
kinetic law: 321051
product: 321039
reactant: 321027
reactant: 321015
fast: false
reversible: true

321051
type: KineticLaw
local parameters: 036992
local parameters: 036990
notes: k1*PP1_PSD_slash_I1*PKA_minus_active-k2*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx

036992
type: LocalParameter
units: 319057
value: 3.24E-15

036990
type: LocalParameter
units: 319142
value: 5.99994E-17

321039
type: SpeciesReference
stoichiometry: 1.0
species: 710881

321027
type: SpeciesReference
stoichiometry: 1.0
species: 710841

321015
type: SpeciesReference
stoichiometry: 1.0
species: 711701

713101
type: Reaction
kinetic law: 320517
product: 320505
product: 320493
reactant: 320481
fast: false
reversible: false

320517
type: KineticLaw
local parameters: 036967
notes: k3*PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

036967
type: LocalParameter
units: 319057
value: 2.25E-16

320505
type: SpeciesReference
stoichiometry: 1.0
species: 710701

320493
type: SpeciesReference
stoichiometry: 1.0
species: 710921

320481
type: SpeciesReference
stoichiometry: 1.0
species: 710721

710622
type: Compartment
constant: true
size: 1.0E-18
spatial dimensions: 3.0

714221
type: Reaction
kinetic law: 323232
product: 323220
product: 323208
reactant: 323196
fast: false
reversible: false

323232
type: KineticLaw
local parameters: 037103
notes: k3*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx

037103
type: LocalParameter
units: 319057
value: 3.06E-17

323220
type: SpeciesReference
stoichiometry: 1.0
species: 711921

323208
type: SpeciesReference
stoichiometry: 1.0
species: 711761

323196
type: SpeciesReference
stoichiometry: 1.0
species: 712001

713301
type: Reaction
kinetic law: 321003
product: 320991
product: 320979
reactant: 320967
fast: false
reversible: false

321003
type: KineticLaw
local parameters: 036988
notes: k3*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx

036988
type: LocalParameter
units: 319057
value: 8.1E-16

320991
type: SpeciesReference
stoichiometry: 1.0
species: 710841

320979
type: SpeciesReference
stoichiometry: 1.0
species: 711201

320967
type: SpeciesReference
stoichiometry: 1.0
species: 710861

714261
type: Reaction
kinetic law: 323328
product: 323316
product: 323304
reactant: 323292
fast: false
reversible: false

323328
type: KineticLaw
local parameters: 037108
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx

037108
type: LocalParameter
units: 319057
value: 6.0E-17

323316
type: SpeciesReference
stoichiometry: 1.0
species: 712361

323304
type: SpeciesReference
stoichiometry: 1.0
species: 711541

323292
type: SpeciesReference
stoichiometry: 1.0
species: 712041

713481
type: Reaction
kinetic law: 321438
product: 321426
reactant: 321414
reactant: 321402
fast: false
reversible: true

321438
type: KineticLaw
local parameters: 037012
local parameters: 037010
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx

037012
type: LocalParameter
units: 319057
value: 1.8E-16

037010
type: LocalParameter
units: 319142
value: 6.428808E-19

321426
type: SpeciesReference
stoichiometry: 1.0
species: 711061

321414
type: SpeciesReference
stoichiometry: 1.0
species: 712221

321402
type: SpeciesReference
stoichiometry: 1.0
species: 710921

713361
type: Reaction
kinetic law: 321147
product: 321135
reactant: 321123
reactant: 321111
notes: Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
fast: false
reversible: true

321147
type: KineticLaw
local parameters: 036997
local parameters: 036995
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx

036997
type: LocalParameter
units: 319057
value: 2.16E-15

036995
type: LocalParameter
units: 319142
value: 1.1894364E-17

321135
type: SpeciesReference
stoichiometry: 1.0
species: 711001

321123
type: SpeciesReference
stoichiometry: 1.0
species: 712201

321111
type: SpeciesReference
stoichiometry: 1.0
species: 710981

714001
type: Reaction
kinetic law: 322704
product: 322692
reactant: 322680
reactant: 322668
fast: false
reversible: true

322704
type: KineticLaw
local parameters: 037077
local parameters: 037075
notes: k1*CaMKII_minus_thr305_minus_PSD*PP1_minus_active_PSD-k2*PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

037077
type: LocalParameter
units: 319057
value: 8.0E-18

037075
type: LocalParameter
units: 319142
value: 4.99998E-18

322692
type: SpeciesReference
stoichiometry: 1.0
species: 711861

322680
type: SpeciesReference
stoichiometry: 1.0
species: 711781

322668
type: SpeciesReference
stoichiometry: 1.0
species: 712101

712921
type: Reaction
kinetic law: 320116
product: 320104
reactant: 320091
notes: Diffusional equilibrium between PSD- and cytosolic compartment. According to D. Bary in Cell Movements 2nd ed 2001 D for proteins is 5e-7 cm^2/s giving 10 ms for a translocation of 1 um.
fast: false
reversible: true

320116
type: KineticLaw
local parameters: 036950
local parameters: 036948
notes: kf*CaM_minus_Ca4_minus_PSD-kb*CaM_minus_Ca4

036950
type: LocalParameter
units: 319057
value: 5.4E-15

036948
type: LocalParameter
units: 319057
value: 5.4E-15

320104
type: SpeciesReference
stoichiometry: 1.0
species: 710681

320091
type: SpeciesReference
stoichiometry: 1.0
species: 711661

712961
type: Reaction
kinetic law: 320213
product: 320201
reactant: 320188
reactant: 320176
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true

320213
type: KineticLaw
local parameters: 036954
local parameters: 036953
notes: kf*PP1_PSD_slash_I1_star_*PP1_minus_active_PSD-kb*PP1_PSD_slash_PP1_minus_I1_star_

036954
type: LocalParameter
units: 319057
value: 1.0E-18

036953
type: LocalParameter
units: 319142
value: 4.9998E-15

320201
type: SpeciesReference
stoichiometry: 1.0
species: 711741

320188
type: SpeciesReference
stoichiometry: 1.0
species: 711781

320176
type: SpeciesReference
stoichiometry: 1.0
species: 711721

713761
type: Reaction
kinetic law: 322124
product: 322112
reactant: 322100
reactant: 322088
fast: false
reversible: true

322124
type: KineticLaw
local parameters: 037047
local parameters: 037045
notes: k1*CaMKII_minus_thr286_minus_PSD*tot_minus_auto_minus_PSD-k2*tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx

037047
type: LocalParameter
units: 319057
value: 2.4E-16

037045
type: LocalParameter
units: 319142
value: 6.0E-19

322112
type: SpeciesReference
stoichiometry: 1.0
species: 711561

322100
type: SpeciesReference
stoichiometry: 1.0
species: 712241

322088
type: SpeciesReference
stoichiometry: 1.0
species: 711501

713501
type: Reaction
kinetic law: 321486
product: 321474
product: 321462
reactant: 321450
fast: false
reversible: false

321486
type: KineticLaw
local parameters: 037013
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx

037013
type: LocalParameter
units: 319057
value: 4.5E-17

321474
type: SpeciesReference
stoichiometry: 1.0
species: 712221

321462
type: SpeciesReference
stoichiometry: 1.0
species: 710941

321450
type: SpeciesReference
stoichiometry: 1.0
species: 711061

713341
type: Reaction
kinetic law: 321099
product: 321087
product: 321075
reactant: 321063
fast: false
reversible: false

321099
type: KineticLaw
local parameters: 036993
notes: k3*PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx

036993
type: LocalParameter
units: 319057
value: 8.1E-16

321087
type: SpeciesReference
stoichiometry: 1.0
species: 710841

321075
type: SpeciesReference
stoichiometry: 1.0
species: 711721

321063
type: SpeciesReference
stoichiometry: 1.0
species: 710881

713541
type: Reaction
kinetic law: 321582
product: 321570
product: 321558
reactant: 321546
fast: false
reversible: false

321582
type: KineticLaw
local parameters: 037018
notes: k3*PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx

037018
type: LocalParameter
units: 319057
value: 1.8E-16

321570
type: SpeciesReference
stoichiometry: 1.0
species: 711261

321558
type: SpeciesReference
stoichiometry: 1.0
species: 711181

321546
type: SpeciesReference
stoichiometry: 1.0
species: 711281

712721
type: Reaction
kinetic law: 319639
product: 319627
product: 319615
reactant: 319603
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true

319639
type: KineticLaw
local parameters: 036929
local parameters: 036928
notes: kf*PP1_slash_PP1_minus_I1-kb*PP1_minus_active*PP1_slash_I1

036929
type: LocalParameter
units: 319142
value: 0.0

036928
type: LocalParameter
units: 319057
value: 9.0E-17

319627
type: SpeciesReference
stoichiometry: 1.0
species: 711181

319615
type: SpeciesReference
stoichiometry: 1.0
species: 710701

319603
type: SpeciesReference
stoichiometry: 1.0
species: 711241

714301
type: Reaction
kinetic law: 323425
product: 323413
product: 323400
reactant: 323388
fast: false
reversible: false

323425
type: KineticLaw
local parameters: 037113
notes: k3*tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx

037113
type: LocalParameter
units: 319057
value: 5.0E-18

323413
type: SpeciesReference
stoichiometry: 1.0
species: 712361

323400
type: SpeciesReference
stoichiometry: 1.0
species: 711461

323388
type: SpeciesReference
stoichiometry: 1.0
species: 712061

712281
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 710661

713683
type: Reaction
kinetic law: 321931
product: 321919
reactant: 321907
reactant: 321895
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true

321931
type: KineticLaw
local parameters: 037037
local parameters: 037035
notes: k1*PP1_slash_I1_star_*CaNAB_minus_Ca4-k2*CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx

037037
type: LocalParameter
units: 319057
value: 1.224E-17

037035
type: LocalParameter
units: 319142
value: 3.0779838E-18

321919
type: SpeciesReference
stoichiometry: 1.0
species: 711381

321907
type: SpeciesReference
stoichiometry: 1.0
species: 711361

321895
type: SpeciesReference
stoichiometry: 1.0
species: 711201

714081
type: Reaction
kinetic law: 322896
product: 322884
reactant: 322872
reactant: 322860
fast: false
reversible: true

322896
type: KineticLaw
local parameters: 037087
local parameters: 037085
notes: k1*PP1_slash_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx

037087
type: LocalParameter
units: 319057
value: 1.224E-16

037085
type: LocalParameter
units: 319142
value: 3.0779838E-17

322884
type: SpeciesReference
stoichiometry: 1.0
species: 711941

322872
type: SpeciesReference
stoichiometry: 1.0
species: 711921

322860
type: SpeciesReference
stoichiometry: 1.0
species: 711201

713561
type: Reaction
kinetic law: 321630
product: 321618
reactant: 321606
reactant: 321594
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true

321630
type: KineticLaw
local parameters: 037022
local parameters: 037020
notes: k1*PP1_slash_PP1_minus_I1_star_*PP2A-k2*PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx

037022
type: LocalParameter
units: 319057
value: 7.50006E-16

037020
type: LocalParameter
units: 319142
value: 5.81256E-17

321618
type: SpeciesReference
stoichiometry: 1.0
species: 711301

321606
type: SpeciesReference
stoichiometry: 1.0
species: 711261

321594
type: SpeciesReference
stoichiometry: 1.0
species: 711221

713901
type: Reaction
kinetic law: 322462
product: 322450
product: 322438
reactant: 322425
fast: false
reversible: false

322462
type: KineticLaw
local parameters: 037063
notes: k3*PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

037063
type: LocalParameter
units: 319057
value: 2.0E-18

322450
type: SpeciesReference
stoichiometry: 1.0
species: 711781

322438
type: SpeciesReference
stoichiometry: 1.0
species: 711481

322425
type: SpeciesReference
stoichiometry: 1.0
species: 711801

712781
type: Reaction
kinetic law: 319788
product: 319776
reactant: 319764
reactant: 319751
fast: false
reversible: true

319788
type: KineticLaw
local parameters: 036935
local parameters: 036934
notes: kf*CaM_minus_Ca4*CaNAB_minus_Ca4-kb*CaM_Ca_n_minus_CaNAB

036935
type: LocalParameter
units: 319057
value: 9.0E-17

036934
type: LocalParameter
units: 319142
value: 5.399946E-14

319776
type: SpeciesReference
stoichiometry: 1.0
species: 711921

319764
type: SpeciesReference
stoichiometry: 1.0
species: 711361

319751
type: SpeciesReference
stoichiometry: 1.0
species: 710681

714201
type: Reaction
kinetic law: 323184
product: 323172
reactant: 323160
reactant: 323148
fast: false
reversible: true

323184
type: KineticLaw
local parameters: 037102
local parameters: 037100
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*CaM_Ca_n_minus_CaNAB-k2*CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx

037102
type: LocalParameter
units: 319057
value: 1.224E-16

037100
type: LocalParameter
units: 319142
value: 3.420036E-18

323172
type: SpeciesReference
stoichiometry: 1.0
species: 712001

323160
type: SpeciesReference
stoichiometry: 1.0
species: 711921

323148
type: SpeciesReference
stoichiometry: 1.0
species: 711741

712601
type: Reaction
kinetic law: 319349
product: 319337
reactant: 319325
reactant: 319313
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true

319349
type: KineticLaw
local parameters: 036913
local parameters: 036912
notes: kf*CaM_slash_CaM*Ca^2-kb*CaM_minus_TR2_minus_Ca2

036913
type: LocalParameter
units: 319057
value: 6.48E-15

036912
type: LocalParameter
units: 319093
value: 6.47990604E-15

319337
type: SpeciesReference
stoichiometry: 1.0
species: 711161

319325
type: SpeciesReference
stoichiometry: 2.0
species: 710821

319313
type: SpeciesReference
stoichiometry: 1.0
species: 711101

712341
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 710641

712881
type: Reaction
kinetic law: 320031
product: 320019
product: 320007
reactant: 319995
notes: Same as for back_1
fast: false
reversible: true

320031
type: KineticLaw
local parameters: 036945
local parameters: 036944
notes: kf*CaMKII_minus_thr305_minus_PSD-kb*CaMKII_slash_CaMK_minus_thr305*NMDAR

036945
type: LocalParameter
units: 319142
value: 5.4E-21

036944
type: LocalParameter
units: 319057
value: 3.0E-18

320019
type: SpeciesReference
stoichiometry: 1.0
species: 711901

320007
type: SpeciesReference
stoichiometry: 1.0
species: 711081

319995
type: SpeciesReference
stoichiometry: 1.0
species: 712101