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notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx

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299011
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notes: k1*AMPAR_memb_slash_A845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx

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569614
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293008
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notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx

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572774
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300753
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notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx

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570014
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293978
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notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx

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569255
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291886
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notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx

052138
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295427
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298625
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notes: k1*CaMKII_slash_CaMKII_star__star__star__minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

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572414
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299884
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notes: k1*AMPAR_memb_slash_A831_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx

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notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx

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571694
type: Reaction
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reactant: 298103
notes: This form has about twice the activity of the unphosphorylated form. See Sette et al JBC 269:28 18271-18274 1994. We\'ll ignore cGMP effects for now.
fast: false
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298139
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notes: k1*AC_slash_cAMP*AC_slash_cAMP_minus_PDE_star_-k2*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx

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296634
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notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx

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571234
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297022
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notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx

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568115
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product: 288962
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288986
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notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx

051946
type: LocalParameter
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value: 5.0E-18

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fast: false
reversible: true

294269
type: KineticLaw
local parameters: 052298
local parameters: 052295
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx

052298
type: LocalParameter
units: 284709
value: 7.2E-16

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type: LocalParameter
units: 284793
value: 2.011824E-17

294257
type: SpeciesReference
stoichiometry: 1.0
species: 562415

562415
type: Species
constant: false
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species: 561675

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species: 565075

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571654
type: Reaction
kinetic law: 298043
product: 298031
reactant: 298019
reactant: 298007
notes: Best rates are from Conti et al Biochem 34 7979-7987 1995. Though these are for the Sertoli cell form, it looks like they carry nicely into alternatively spliced brain form. See Sette et al JBC 269:28 18271-18274 Km ~2 uM, Vmax est ~ 10 umol/min/mg for pure form. Brain protein is 93 kD but this was 67. So k3 ~10, k2 ~40, k1 ~4.2e-6
fast: false
reversible: true

298043
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notes: k1*AC_slash_cAMP*AC_slash_cAMP_minus_PDE-k2*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx

052546
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units: 284709
value: 3.6E-15

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type: LocalParameter
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value: 2.2680162E-16

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species: 563455

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species: 563635

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566915
type: Reaction
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product: 286207
reactant: 286194
reactant: 286181
fast: false
reversible: true

286219
type: KineticLaw
local parameters: 051780
local parameters: 051778
notes: kf*PKA_slash_R2C2_minus_cAMP2*AC_slash_cAMP-kb*PKA_slash_R2C2_minus_cAMP3

051780
type: LocalParameter
units: 284709
value: 9.9E-15

051778
type: LocalParameter
units: 284793
value: 6.750054E-15

286207
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constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

286194
type: SpeciesReference
stoichiometry: 1.0
species: 563635

286181
type: SpeciesReference
stoichiometry: 1.0
species: 562515

562515
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

563695
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

564435
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

564695
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

568775
type: Reaction
kinetic law: 290581
product: 290568
reactant: 290556
reactant: 290544
fast: false
reversible: true

290581
type: KineticLaw
local parameters: 052058
local parameters: 052055
notes: k1*CaMKII_slash_CaMK_minus_thr305*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

052058
type: LocalParameter
units: 284709
value: 9.0E-16

052055
type: LocalParameter
units: 284793
value: 2.2062942E-16

290568
type: SpeciesReference
stoichiometry: 1.0
species: 561555

561555
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

290556
type: SpeciesReference
stoichiometry: 1.0
species: 561455

561455
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 560155

290544
type: SpeciesReference
stoichiometry: 1.0
species: 560415

560415
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

569115
type: Reaction
kinetic law: 291404
product: 291392
product: 291380
reactant: 291368
fast: false
reversible: false

291404
type: KineticLaw
local parameters: 052107
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx

052107
type: LocalParameter
units: 284709
value: 1.8E-16

291392
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291380
type: SpeciesReference
stoichiometry: 1.0
species: 564655

564655
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

291368
type: SpeciesReference
stoichiometry: 1.0
species: 561795

561795
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

563435
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

570914
type: Reaction
kinetic law: 296153
product: 296141
product: 296129
reactant: 296117
fast: false
reversible: false

296153
type: KineticLaw
local parameters: 052421
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx

052421
type: LocalParameter
units: 284709
value: 5.4E-16

296141
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296129
type: SpeciesReference
stoichiometry: 1.0
species: 564775

564775
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

296117
type: SpeciesReference
stoichiometry: 1.0
species: 562995

562995
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

563855
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

570554
type: Reaction
kinetic law: 295283
product: 295270
product: 295258
reactant: 295246
fast: false
reversible: false

295283
type: KineticLaw
local parameters: 052366
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx

052366
type: LocalParameter
units: 284709
value: 5.4E-16

295270
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295258
type: SpeciesReference
stoichiometry: 1.0
species: 564735

564735
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

295246
type: SpeciesReference
stoichiometry: 1.0
species: 562815

562815
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

568175
type: Reaction
kinetic law: 289132
product: 289119
reactant: 289106
reactant: 289094
fast: false
reversible: true

289132
type: KineticLaw
local parameters: 051956
local parameters: 051954
notes: k1*AMPAR_memb_slash_A_B831_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx

051956
type: LocalParameter
units: 284709
value: 2.0E-17

051954
type: LocalParameter
units: 284793
value: 2.77776E-19

289119
type: SpeciesReference
stoichiometry: 1.0
species: 560855

560855
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 560175

289106
type: SpeciesReference
stoichiometry: 1.0
species: 565595

289094
type: SpeciesReference
stoichiometry: 1.0
species: 565000

565000
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

566395
type: Reaction
kinetic law: 284998
product: 284986
product: 284973
reactant: 284961
notes: Same as for back_1
fast: false
reversible: true

284998
type: KineticLaw
local parameters: 051702
local parameters: 051700
notes: kf*CaMKII_slash_CaMKII_minus_thr305_minus_PSD-kb*CaMKII_slash_CaMK_minus_thr305*CaMKII_slash_NMDAR

051702
type: LocalParameter
units: 284793
value: 5.4E-21

051700
type: LocalParameter
units: 284709
value: 3.0E-18

284986
type: SpeciesReference
stoichiometry: 1.0
species: 560495

560495
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120.0
initial amount: NaN
in compartment: 560175

284973
type: SpeciesReference
stoichiometry: 1.0
species: 560415

284961
type: SpeciesReference
stoichiometry: 1.0
species: 560435

560435
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

571774
type: Reaction
kinetic law: 298333
product: 298321
reactant: 298309
reactant: 298296
notes: Max activity ~10umol/min/mg in presence of lots of CaM. Affinity is low, 40 uM. k3 = 10, k2 = 40, k1 = (50/40) / 6e5.
fast: false
reversible: true

298333
type: KineticLaw
local parameters: 052565
local parameters: 052562
notes: k1*AC_slash_cAMP*AC_slash_CaM_dot_PDE1-k2*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx

052565
type: LocalParameter
units: 284709
value: 3.6E-15

052562
type: LocalParameter
units: 284793
value: 1.1339838E-16

298321
type: SpeciesReference
stoichiometry: 1.0
species: 563595

563595
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

298309
type: SpeciesReference
stoichiometry: 1.0
species: 563575

563575
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

298296
type: SpeciesReference
stoichiometry: 1.0
species: 563635

568595
type: Reaction
kinetic law: 290146
product: 290134
product: 290122
reactant: 290110
fast: false
reversible: false

290146
type: KineticLaw
local parameters: 052021
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx

052021
type: LocalParameter
units: 284709
value: 1.8E-16

290134
type: SpeciesReference
stoichiometry: 1.0
species: 561355

561355
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.111111111111111
initial amount: NaN
in compartment: 560155

290122
type: SpeciesReference
stoichiometry: 1.0
species: 563735

563735
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

290110
type: SpeciesReference
stoichiometry: 1.0
species: 561435

566655
type: Reaction
kinetic law: 285609
product: 285596
reactant: 285584
reactant: 285572
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true

285609
type: KineticLaw
local parameters: 051741
local parameters: 051739
notes: kf*CaM_slash_CaM_minus_TR2_minus_Ca2_minus_PSD*Ca_minus_PSD-kb*CaM_slash_CaM_minus_Ca3_minus_PSD

051741
type: LocalParameter
units: 284709
value: 1.0E-16

051739
type: LocalParameter
units: 284793
value: 3.6E-17

285596
type: SpeciesReference
stoichiometry: 1.0
species: 561215

561215
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

285584
type: SpeciesReference
stoichiometry: 1.0
species: 563655

563655
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 560175

285572
type: SpeciesReference
stoichiometry: 1.0
species: 561235

561235
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

560515
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

572654
type: Reaction
kinetic law: 300463
product: 300451
reactant: 300439
reactant: 300427
fast: false
reversible: true

300463
type: KineticLaw
local parameters: 052709
local parameters: 052706
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx

052709
type: LocalParameter
units: 284709
value: 6.8E-18

052706
type: LocalParameter
units: 284793
value: 8.7498E-18

300451
type: SpeciesReference
stoichiometry: 1.0
species: 564195

564195
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

300439
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300427
type: SpeciesReference
stoichiometry: 1.0
species: 565255

565255
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

570934
type: Reaction
kinetic law: 296201
product: 296189
reactant: 296177
reactant: 296165
fast: false
reversible: true

296201
type: KineticLaw
local parameters: 052426
local parameters: 052423
notes: k1*AMPAR_slash_A845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx

052426
type: LocalParameter
units: 284709
value: 2.16E-15

052423
type: LocalParameter
units: 284793
value: 3.5998992E-16

296189
type: SpeciesReference
stoichiometry: 1.0
species: 563015

563015
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

296177
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296165
type: SpeciesReference
stoichiometry: 1.0
species: 564895

564895
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

562615
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.259259259259259
initial amount: NaN
in compartment: 560155

572954
type: Reaction
kinetic law: 301188
product: 301176
product: 301164
reactant: 301152
fast: false
reversible: false

301188
type: KineticLaw
local parameters: 052756
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx

052756
type: LocalParameter
units: 284709
value: 3.5E-18

301176
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301164
type: SpeciesReference
stoichiometry: 1.0
species: 565235

565235
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

301152
type: SpeciesReference
stoichiometry: 1.0
species: 564335

564335
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

572134
type: Reaction
kinetic law: 299206
product: 299194
reactant: 299182
reactant: 299170
fast: false
reversible: true

299206
type: KineticLaw
local parameters: 052623
local parameters: 052620
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx

052623
type: LocalParameter
units: 284709
value: 6.8E-18

052620
type: LocalParameter
units: 284793
value: 8.7498E-18

299194
type: SpeciesReference
stoichiometry: 1.0
species: 563935

563935
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

299182
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299170
type: SpeciesReference
stoichiometry: 1.0
species: 565215

565215
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

561155
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

563955
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

561615
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

569355
type: Reaction
kinetic law: 292273
product: 292261
product: 292249
reactant: 292236
fast: false
reversible: false

292273
type: KineticLaw
local parameters: 052163
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx

052163
type: LocalParameter
units: 284709
value: 1.8E-16

292261
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292249
type: SpeciesReference
stoichiometry: 1.0
species: 564955

564955
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

292236
type: SpeciesReference
stoichiometry: 1.0
species: 561975

561975
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

571794
type: Reaction
kinetic law: 298382
product: 298370
product: 298358
reactant: 298345
fast: false
reversible: false

298382
type: KineticLaw
local parameters: 052566
notes: k3*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx

052566
type: LocalParameter
units: 284709
value: 9.0E-16

298370
type: SpeciesReference
stoichiometry: 1.0
species: 563575

298358
type: SpeciesReference
stoichiometry: 1.0
species: 563435

298345
type: SpeciesReference
stoichiometry: 1.0
species: 563595

572714
type: Reaction
kinetic law: 300609
product: 300596
product: 300584
reactant: 300572
fast: false
reversible: false

300609
type: KineticLaw
local parameters: 052716
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx

052716
type: LocalParameter
units: 284709
value: 1.7E-18

300596
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300584
type: SpeciesReference
stoichiometry: 1.0
species: 565015

565015
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

300572
type: SpeciesReference
stoichiometry: 1.0
species: 564215

564215
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

564175
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

563555
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

560795
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 560175

564615
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

568055
type: Reaction
kinetic law: 288840
product: 288828
reactant: 288816
reactant: 288804
fast: false
reversible: true

288840
type: KineticLaw
local parameters: 051939
local parameters: 051937
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx

051939
type: LocalParameter
units: 284709
value: 2.0E-17

051937
type: LocalParameter
units: 284793
value: 2.77776E-19

288828
type: SpeciesReference
stoichiometry: 1.0
species: 560795

288816
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288804
type: SpeciesReference
stoichiometry: 1.0
species: 565235

563615
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560195

560195
type: Compartment
constant: true
size: 5.0E-15
spatial dimensions: 3.0

567615
type: Reaction
kinetic law: 287777
product: 287765
reactant: 287753
reactant: 287741
fast: false
reversible: true

287777
type: KineticLaw
local parameters: 051883
local parameters: 051881
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx

051883
type: LocalParameter
units: 284709
value: 1.8E-16

051881
type: LocalParameter
units: 284793
value: 1.2857616E-18

287765
type: SpeciesReference
stoichiometry: 1.0
species: 560395

287753
type: SpeciesReference
stoichiometry: 1.0
species: 565495

287741
type: SpeciesReference
stoichiometry: 1.0
species: 560255

560255
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

564595
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

566535
type: Reaction
kinetic law: 285328
product: 285316
reactant: 285303
reactant: 285290
notes: Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
fast: false
reversible: true

285328
type: KineticLaw
local parameters: 051723
local parameters: 051721
notes: kf*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*CaM_slash_CaM_minus_Ca4_minus_PSD-kb*CaMKII_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD

051723
type: LocalParameter
units: 284709
value: 1.0E-18

051721
type: LocalParameter
units: 284793
value: 1.00002E-14

285316
type: SpeciesReference
stoichiometry: 1.0
species: 560555

560555
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

285303
type: SpeciesReference
stoichiometry: 1.0
species: 561195

561195
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

285290
type: SpeciesReference
stoichiometry: 1.0
species: 560515

570814
type: Reaction
kinetic law: 295912
product: 295900
reactant: 295888
reactant: 295876
fast: false
reversible: true

295912
type: KineticLaw
local parameters: 052408
local parameters: 052405
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx

052408
type: LocalParameter
units: 284709
value: 2.16E-15

052405
type: LocalParameter
units: 284793
value: 3.5998992E-16

295900
type: SpeciesReference
stoichiometry: 1.0
species: 562955

295888
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295876
type: SpeciesReference
stoichiometry: 1.0
species: 564855

564855
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

572834
type: Reaction
kinetic law: 300897
product: 300885
product: 300873
reactant: 300861
fast: false
reversible: false

300897
type: KineticLaw
local parameters: 052737
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx

052737
type: LocalParameter
units: 284709
value: 3.5E-18

300885
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300873
type: SpeciesReference
stoichiometry: 1.0
species: 565135

300861
type: SpeciesReference
stoichiometry: 1.0
species: 564275

564275
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

570074
type: Reaction
kinetic law: 294123
product: 294110
product: 294098
reactant: 294086
fast: false
reversible: false

294123
type: KineticLaw
local parameters: 052285
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx

052285
type: LocalParameter
units: 284709
value: 1.8E-16

294110
type: SpeciesReference
stoichiometry: 1.0
species: 561675

294098
type: SpeciesReference
stoichiometry: 1.0
species: 565195

294086
type: SpeciesReference
stoichiometry: 1.0
species: 562375

562375
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

567135
type: Reaction
kinetic law: 286717
product: 286705
reactant: 286693
reactant: 286681
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true

286717
type: KineticLaw
local parameters: 051813
local parameters: 051811
notes: kf*PP1_PSD_slash_I1_star_*PP1_PSD_slash_PP1_minus_active_PSD-kb*PP1_PSD_slash_PP1_minus_I1_star_

051813
type: LocalParameter
units: 284709
value: 1.0E-18

051811
type: LocalParameter
units: 284793
value: 4.9998E-15

286705
type: SpeciesReference
stoichiometry: 1.0
species: 563715

563715
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

286693
type: SpeciesReference
stoichiometry: 1.0
species: 563755

286681
type: SpeciesReference
stoichiometry: 1.0
species: 563695

570494
type: Reaction
kinetic law: 295138
product: 295126
reactant: 295114
reactant: 295102
fast: false
reversible: true

295138
type: KineticLaw
local parameters: 052359
local parameters: 052356
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx

052359
type: LocalParameter
units: 284709
value: 2.16E-15

052356
type: LocalParameter
units: 284793
value: 3.5998992E-16

295126
type: SpeciesReference
stoichiometry: 1.0
species: 562795

562795
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

295114
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295102
type: SpeciesReference
stoichiometry: 1.0
species: 564915

564915
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

569235
type: Reaction
kinetic law: 291789
product: 291777
product: 291765
reactant: 291753
fast: false
reversible: false

291789
type: KineticLaw
local parameters: 052131
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx

052131
type: LocalParameter
units: 284709
value: 1.8E-16

291777
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291765
type: SpeciesReference
stoichiometry: 1.0
species: 564655

291753
type: SpeciesReference
stoichiometry: 1.0
species: 561875

561875
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

572854
type: Reaction
kinetic law: 300945
product: 300933
reactant: 300921
reactant: 300909
fast: false
reversible: true

300945
type: KineticLaw
local parameters: 052742
local parameters: 052739
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx

052742
type: LocalParameter
units: 284709
value: 1.4E-17

052739
type: LocalParameter
units: 284793
value: 8.7498E-18

300933
type: SpeciesReference
stoichiometry: 1.0
species: 564295

564295
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

300921
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300909
type: SpeciesReference
stoichiometry: 1.0
species: 565115

567195
type: Reaction
kinetic law: 286862
product: 286850
product: 286838
reactant: 286826
fast: false
reversible: true

286862
type: KineticLaw
local parameters: 051822
local parameters: 051820
notes: kf*AMPAR_memb_slash_A831_star__B-kb*AMPAR_slash_A831_star__B*AMPAR_memb_slash_Anchor

051822
type: LocalParameter
units: 284793
value: 0.0

051820
type: LocalParameter
units: 284709
value: 8.0E-21

286850
type: SpeciesReference
stoichiometry: 1.0
species: 565295

565295
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 27.3333333333333
initial amount: NaN
in compartment: 560175

286838
type: SpeciesReference
stoichiometry: 1.0
species: 564675

286826
type: SpeciesReference
stoichiometry: 1.0
species: 564995

565715
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

569534
type: Reaction
kinetic law: 292812
product: 292800
reactant: 292788
reactant: 292776
fast: false
reversible: true

292812
type: KineticLaw
local parameters: 052202
local parameters: 052199
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx

052202
type: LocalParameter
units: 284709
value: 7.2E-16

052199
type: LocalParameter
units: 284793
value: 1.8106416E-16

292800
type: SpeciesReference
stoichiometry: 1.0
species: 562095

562095
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

292788
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292776
type: SpeciesReference
stoichiometry: 1.0
species: 564815

564815
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

564035
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

563035
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

564455
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

562835
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

569294
type: Reaction
kinetic law: 292031
product: 292019
reactant: 292007
reactant: 291995
fast: false
reversible: true

292031
type: KineticLaw
local parameters: 052149
local parameters: 052146
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx

052149
type: LocalParameter
units: 284709
value: 7.2E-16

052146
type: LocalParameter
units: 284793
value: 1.8106416E-16

292019
type: SpeciesReference
stoichiometry: 1.0
species: 561935

561935
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

292007
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291995
type: SpeciesReference
stoichiometry: 1.0
species: 564855

562315
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

571674
type: Reaction
kinetic law: 298091
product: 298079
product: 298067
reactant: 298055
fast: false
reversible: false

298091
type: KineticLaw
local parameters: 052547
notes: k3*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx

052547
type: LocalParameter
units: 284709
value: 9.0E-16

298079
type: SpeciesReference
stoichiometry: 1.0
species: 563455

298067
type: SpeciesReference
stoichiometry: 1.0
species: 563435

298055
type: SpeciesReference
stoichiometry: 1.0
species: 563475

568795
type: Reaction
kinetic law: 290629
product: 290617
product: 290605
reactant: 290593
fast: false
reversible: false

290629
type: KineticLaw
local parameters: 052059
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

052059
type: LocalParameter
units: 284709
value: 2.25E-16

290617
type: SpeciesReference
stoichiometry: 1.0
species: 561455

290605
type: SpeciesReference
stoichiometry: 1.0
species: 560235

560235
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 20.0
initial amount: NaN
in compartment: 560155

290593
type: SpeciesReference
stoichiometry: 1.0
species: 561555

562115
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 560155

569135
type: Reaction
kinetic law: 291500
product: 291488
product: 291476
reactant: 291464
fast: false
reversible: false

291500
type: KineticLaw
local parameters: 052113
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx

052113
type: LocalParameter
units: 284709
value: 1.8E-16

291488
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291476
type: SpeciesReference
stoichiometry: 1.0
species: 564675

291464
type: SpeciesReference
stoichiometry: 1.0
species: 561815

561815
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

571974
type: Reaction
kinetic law: 298818
product: 298806
reactant: 298794
reactant: 298782
fast: false
reversible: true

298818
type: KineticLaw
local parameters: 052597
local parameters: 052594
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx

052597
type: LocalParameter
units: 284709
value: 6.8E-18

052594
type: LocalParameter
units: 284793
value: 8.7498E-18

298806
type: SpeciesReference
stoichiometry: 1.0
species: 563855

298794
type: SpeciesReference
stoichiometry: 1.0
species: 563755

298782
type: SpeciesReference
stoichiometry: 1.0
species: 565135

560875
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 560175

569934
type: Reaction
kinetic law: 293784
product: 293772
reactant: 293760
reactant: 293748
fast: false
reversible: true

293784
type: KineticLaw
local parameters: 052264
local parameters: 052261
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx

052264
type: LocalParameter
units: 284709
value: 7.2E-16

052261
type: LocalParameter
units: 284793
value: 2.011824E-17

293772
type: SpeciesReference
stoichiometry: 1.0
species: 562315

293760
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293748
type: SpeciesReference
stoichiometry: 1.0
species: 565235

566615
type: Reaction
kinetic law: 285510
product: 285498
reactant: 285486
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true

285510
type: KineticLaw
local parameters: 051735
local parameters: 051733
notes: kf*CaM_slash_neurogranin_star_-kb*CaM_slash_neurogranin

051735
type: LocalParameter
units: 284709
value: 0.0

051733
type: LocalParameter
units: 284709
value: 4.5E-19

285498
type: SpeciesReference
stoichiometry: 1.0
species: 561055

561055
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 560155

285486
type: SpeciesReference
stoichiometry: 1.0
species: 561035

567015
type: Reaction
kinetic law: 286463
product: 286451
reactant: 286439
reactant: 286427
notes: Half-max at 20 nM CaM (Tang et al JBC 266:13 8595-8603 1991 kb/kf = 20 nM = 12000 #/cell so kf = kb/12000 = kb * 8.333e-5
fast: false
reversible: true

286463
type: KineticLaw
local parameters: 051795
local parameters: 051793
notes: kf*CaM_slash_CaM_minus_Ca4*AC_slash_AC1-kb*AC_slash_AC1_minus_CaM

051795
type: LocalParameter
units: 284709
value: 9.0E-17

051793
type: LocalParameter
units: 284793
value: 4.4999712E-15

286451
type: SpeciesReference
stoichiometry: 1.0
species: 563375

563375
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

286439
type: SpeciesReference
stoichiometry: 1.0
species: 562115

286427
type: SpeciesReference
stoichiometry: 1.0
species: 561255

561255
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

564935
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

570374
type: Reaction
kinetic law: 294850
product: 294838
reactant: 294826
reactant: 294814
fast: false
reversible: true

294850
type: KineticLaw
local parameters: 052340
local parameters: 052337
notes: k1*AMPAR_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx

052340
type: LocalParameter
units: 284709
value: 2.16E-15

052337
type: LocalParameter
units: 284793
value: 3.5998992E-16

294838
type: SpeciesReference
stoichiometry: 1.0
species: 562735

562735
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

294826
type: SpeciesReference
stoichiometry: 1.0
species: 562655

294814
type: SpeciesReference
stoichiometry: 1.0
species: 564655

569415
type: Reaction
kinetic law: 292475
product: 292463
product: 292451
reactant: 292439
fast: false
reversible: false

292475
type: KineticLaw
local parameters: 052177
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx

052177
type: LocalParameter
units: 284709
value: 1.8E-16

292463
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292451
type: SpeciesReference
stoichiometry: 1.0
species: 564855

292439
type: SpeciesReference
stoichiometry: 1.0
species: 562015

567075
type: Reaction
kinetic law: 286584
product: 286572
reactant: 286560
reactant: 286548
notes: For olf epi PDE1, affinity is 7 nM. Assume same for brain. Reaction should be pretty fast. Assume kb = 5/sec. Then kf = 5 / (0.007 * 6e5) = 1.2e-3
fast: false
reversible: true

286584
type: KineticLaw
local parameters: 051804
local parameters: 051802
notes: kf*AC_slash_PDE1*CaM_slash_CaM_minus_Ca4-kb*AC_slash_CaM_dot_PDE1

051804
type: LocalParameter
units: 284709
value: 4.5E-16

051802
type: LocalParameter
units: 284793
value: 6.479838E-14

286572
type: SpeciesReference
stoichiometry: 1.0
species: 563575

286560
type: SpeciesReference
stoichiometry: 1.0
species: 561255

286548
type: SpeciesReference
stoichiometry: 1.0
species: 563535

563535
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.59259259259259
initial amount: NaN
in compartment: 560155

568915
type: Reaction
kinetic law: 290920
product: 290908
product: 290896
reactant: 290884
fast: false
reversible: false

290920
type: KineticLaw
local parameters: 052077
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx

052077
type: LocalParameter
units: 284709
value: 6.03E-17

290908
type: SpeciesReference
stoichiometry: 1.0
species: 561675

290896
type: SpeciesReference
stoichiometry: 1.0
species: 561055

290884
type: SpeciesReference
stoichiometry: 1.0
species: 561695

561115
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 560175

561095
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

572114
type: Reaction
kinetic law: 299158
product: 299146
product: 299134
reactant: 299122
fast: false
reversible: false

299158
type: KineticLaw
local parameters: 052618
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx

052618
type: LocalParameter
units: 284709
value: 1.7E-18

299146
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299134
type: SpeciesReference
stoichiometry: 1.0
species: 564975

299122
type: SpeciesReference
stoichiometry: 1.0
species: 563915

563915
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

563155
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

571854
type: Reaction
kinetic law: 298528
product: 298516
reactant: 298504
reactant: 298492
fast: false
reversible: true

298528
type: KineticLaw
local parameters: 052577
local parameters: 052574
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

052577
type: LocalParameter
units: 284709
value: 1.0E-16

052574
type: LocalParameter
units: 284793
value: 6.2502E-17

298516
type: SpeciesReference
stoichiometry: 1.0
species: 563795

563795
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

298504
type: SpeciesReference
stoichiometry: 1.0
species: 563755

298492
type: SpeciesReference
stoichiometry: 1.0
species: 560515

569015
type: Reaction
kinetic law: 291163
product: 291151
reactant: 291139
reactant: 291127
fast: false
reversible: true

291163
type: KineticLaw
local parameters: 052094
local parameters: 052091
notes: k1*PP1_PSD_slash_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx

052094
type: LocalParameter
units: 284709
value: 1.224E-16

052091
type: LocalParameter
units: 284793
value: 3.420036E-18

291151
type: SpeciesReference
stoichiometry: 1.0
species: 561755

561755
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

291139
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291127
type: SpeciesReference
stoichiometry: 1.0
species: 563695

563315
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

568975
type: Reaction
kinetic law: 291066
product: 291054
reactant: 291042
reactant: 291030
fast: false
reversible: true

291066
type: KineticLaw
local parameters: 052088
local parameters: 052085
notes: k1*PP1_slash_PP1_minus_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx

052088
type: LocalParameter
units: 284709
value: 1.224E-16

052085
type: LocalParameter
units: 284793
value: 3.0779838E-17

291054
type: SpeciesReference
stoichiometry: 1.0
species: 561735

561735
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

291042
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291030
type: SpeciesReference
stoichiometry: 1.0
species: 561315

561315
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

572734
type: Reaction
kinetic law: 300657
product: 300645
reactant: 300633
reactant: 300621
fast: false
reversible: true

300657
type: KineticLaw
local parameters: 052722
local parameters: 052719
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx

052722
type: LocalParameter
units: 284709
value: 6.8E-18

052719
type: LocalParameter
units: 284793
value: 8.7498E-18

300645
type: SpeciesReference
stoichiometry: 1.0
species: 564235

564235
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

300633
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300621
type: SpeciesReference
stoichiometry: 1.0
species: 565075

565675
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

565415
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 560155

568075
type: Reaction
kinetic law: 288889
product: 288877
product: 288865
reactant: 288852
fast: false
reversible: false

288889
type: KineticLaw
local parameters: 051942
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx

051942
type: LocalParameter
units: 284709
value: 5.0E-18

288877
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288865
type: SpeciesReference
stoichiometry: 1.0
species: 565255

288852
type: SpeciesReference
stoichiometry: 1.0
species: 560795

567795
type: Reaction
kinetic law: 288212
product: 288200
product: 288188
reactant: 288176
fast: false
reversible: false

288212
type: KineticLaw
local parameters: 051904
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx

051904
type: LocalParameter
units: 284709
value: 5.0E-18

288200
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288188
type: SpeciesReference
stoichiometry: 1.0
species: 565155

288176
type: SpeciesReference
stoichiometry: 1.0
species: 560655

560655
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 560175

565835
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

571034
type: Reaction
kinetic law: 296490
product: 296478
reactant: 296466
reactant: 296454
fast: false
reversible: true

296490
type: KineticLaw
local parameters: 052444
local parameters: 052441
notes: k1*AMPAR_memb_slash_A845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx

052444
type: LocalParameter
units: 284709
value: 2.16E-15

052441
type: LocalParameter
units: 284793
value: 3.999888E-17

296478
type: SpeciesReference
stoichiometry: 1.0
species: 563075

563075
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

296466
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296454
type: SpeciesReference
stoichiometry: 1.0
species: 565035

568495
type: Reaction
kinetic law: 289905
product: 289893
reactant: 289881
reactant: 289869
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true

289905
type: KineticLaw
local parameters: 052008
local parameters: 052006
notes: k1*PP1_slash_PP1_minus_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx

052008
type: LocalParameter
units: 284709
value: 7.50006E-16

052006
type: LocalParameter
units: 284793
value: 5.81256E-17

289893
type: SpeciesReference
stoichiometry: 1.0
species: 561395

561395
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00691
initial amount: NaN
in compartment: 560155

289881
type: SpeciesReference
stoichiometry: 1.0
species: 561355

289869
type: SpeciesReference
stoichiometry: 1.0
species: 561315

570874
type: Reaction
kinetic law: 296057
product: 296045
product: 296033
reactant: 296021
fast: false
reversible: false

296057
type: KineticLaw
local parameters: 052415
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx

052415
type: LocalParameter
units: 284709
value: 5.4E-16

296045
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296033
type: SpeciesReference
stoichiometry: 1.0
species: 564755

564755
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

296021
type: SpeciesReference
stoichiometry: 1.0
species: 562975

562975
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

560575
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

560995
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 560155

566795
type: Reaction
kinetic law: 285926
product: 285914
product: 285902
reactant: 285889
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true

285926
type: KineticLaw
local parameters: 051762
local parameters: 051760
notes: kf*PP1_slash_PP1_minus_I1-kb*PP1_slash_PP1_minus_active*PP1_slash_I1

051762
type: LocalParameter
units: 284793
value: 0.0

051760
type: LocalParameter
units: 284709
value: 9.0E-17

285914
type: SpeciesReference
stoichiometry: 1.0
species: 561275

561275
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 560155

285902
type: SpeciesReference
stoichiometry: 1.0
species: 561455

285889
type: SpeciesReference
stoichiometry: 1.0
species: 561335

561335
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

562675
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

570514
type: Reaction
kinetic law: 295186
product: 295174
product: 295162
reactant: 295150
fast: false
reversible: false

295186
type: KineticLaw
local parameters: 052360
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx

052360
type: LocalParameter
units: 284709
value: 5.4E-16

295174
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295162
type: SpeciesReference
stoichiometry: 1.0
species: 564935

295150
type: SpeciesReference
stoichiometry: 1.0
species: 562795

561915
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

571314
type: Reaction
kinetic law: 297215
product: 297203
product: 297191
reactant: 297179
fast: false
reversible: false

297215
type: KineticLaw
local parameters: 052492
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx

052492
type: LocalParameter
units: 284709
value: 5.4E-16

297203
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297191
type: SpeciesReference
stoichiometry: 1.0
species: 565235

297179
type: SpeciesReference
stoichiometry: 1.0
species: 563215

563215
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

572614
type: Reaction
kinetic law: 300367
product: 300354
reactant: 300342
reactant: 300330
fast: false
reversible: true

300367
type: KineticLaw
local parameters: 052702
local parameters: 052699
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx

052702
type: LocalParameter
units: 284709
value: 6.8E-18

052699
type: LocalParameter
units: 284793
value: 8.7498E-18

300354
type: SpeciesReference
stoichiometry: 1.0
species: 564175

300342
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300330
type: SpeciesReference
stoichiometry: 1.0
species: 565255

568435
type: Reaction
kinetic law: 289760
product: 289748
product: 289736
reactant: 289724
fast: false
reversible: false

289760
type: KineticLaw
local parameters: 051995
notes: k3*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx

051995
type: LocalParameter
units: 284709
value: 5.0E-18

289748
type: SpeciesReference
stoichiometry: 1.0
species: 565615

565615
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

289736
type: SpeciesReference
stoichiometry: 1.0
species: 560555

289724
type: SpeciesReference
stoichiometry: 1.0
species: 560975

560975
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

571154
type: Reaction
kinetic law: 296828
product: 296816
product: 296804
reactant: 296792
fast: false
reversible: false

296828
type: KineticLaw
local parameters: 052464
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx

052464
type: LocalParameter
units: 284709
value: 5.4E-16

296816
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296804
type: SpeciesReference
stoichiometry: 1.0
species: 565215

296792
type: SpeciesReference
stoichiometry: 1.0
species: 563135

563135
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

560675
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 560175

569554
type: Reaction
kinetic law: 292860
product: 292848
product: 292836
reactant: 292824
fast: false
reversible: false

292860
type: KineticLaw
local parameters: 052203
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx

052203
type: LocalParameter
units: 284709
value: 1.8E-16

292848
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292836
type: SpeciesReference
stoichiometry: 1.0
species: 564935

292824
type: SpeciesReference
stoichiometry: 1.0
species: 562095

565535
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 560155

570274
type: Reaction
kinetic law: 294609
product: 294597
product: 294584
reactant: 294572
fast: false
reversible: false

294609
type: KineticLaw
local parameters: 052320
notes: k3*PKA_slash_PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx

052320
type: LocalParameter
units: 284709
value: 8.1E-16

294597
type: SpeciesReference
stoichiometry: 1.0
species: 562655

294584
type: SpeciesReference
stoichiometry: 1.0
species: 563495

294572
type: SpeciesReference
stoichiometry: 1.0
species: 562675

567515
type: Reaction
kinetic law: 287530
product: 287517
product: 287504
reactant: 287491
fast: false
reversible: false

287530
type: KineticLaw
local parameters: 051868
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx

051868
type: LocalParameter
units: 284709
value: 5.4E-16

287517
type: SpeciesReference
stoichiometry: 1.0
species: 565475

287504
type: SpeciesReference
stoichiometry: 1.0
species: 560295

560295
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

287491
type: SpeciesReference
stoichiometry: 1.0
species: 560335

560335
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6.3262962962963E-11
initial amount: NaN
in compartment: 560155

562135
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

571734
type: Reaction
kinetic law: 298236
product: 298224
reactant: 298212
reactant: 298199
notes: Rate is 1/6 of the CaM stim form. We\'ll just reduce all lf k1, k2, k3 so that the Vmax goes down 1/6.
fast: false
reversible: true

298236
type: KineticLaw
local parameters: 052558
local parameters: 052555
notes: k1*AC_slash_cAMP*AC_slash_PDE1-k2*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx

052558
type: LocalParameter
units: 284709
value: 6.003E-16

052555
type: LocalParameter
units: 284793
value: 1.8900054E-17

298224
type: SpeciesReference
stoichiometry: 1.0
species: 563555

298212
type: SpeciesReference
stoichiometry: 1.0
species: 563535

298199
type: SpeciesReference
stoichiometry: 1.0
species: 563635

562915
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

567935
type: Reaction
kinetic law: 288550
product: 288538
reactant: 288526
reactant: 288514
fast: false
reversible: true

288550
type: KineticLaw
local parameters: 051924
local parameters: 051922
notes: k1*AMPAR_memb_slash_A_B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx

051924
type: LocalParameter
units: 284709
value: 2.0E-17

051922
type: LocalParameter
units: 284793
value: 2.77776E-19

288538
type: SpeciesReference
stoichiometry: 1.0
species: 560735

560735
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 560175

288526
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288514
type: SpeciesReference
stoichiometry: 1.0
species: 565095

565095
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

568855
type: Reaction
kinetic law: 290775
product: 290763
reactant: 290751
reactant: 290739
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true

290775
type: KineticLaw
local parameters: 052070
local parameters: 052067
notes: k1*PP1_PSD_slash_I1_star_*PP2B_slash_CaNAB_minus_Ca4-k2*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx

052070
type: LocalParameter
units: 284709
value: 1.224E-17

052067
type: LocalParameter
units: 284793
value: 3.420036E-19

290763
type: SpeciesReference
stoichiometry: 1.0
species: 561655

561655
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

290751
type: SpeciesReference
stoichiometry: 1.0
species: 561615

290739
type: SpeciesReference
stoichiometry: 1.0
species: 563695

563275
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

566635
type: Reaction
kinetic law: 285559
product: 285547
reactant: 285535
reactant: 285523
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true

285559
type: KineticLaw
local parameters: 051738
local parameters: 051736
notes: kf*CaM_slash_CaM_minus_PSD*Ca_minus_PSD^2-kb*CaM_slash_CaM_minus_TR2_minus_Ca2_minus_PSD

051738
type: LocalParameter
units: 284709
value: 7.2E-16

051736
type: LocalParameter
units: 284745
value: 7.2E-16

284781
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

284769
type: SBMLUnit
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE

284757
type: SBMLUnit
exponent: 3.0
scale: 0
multipler: 1.0
kind: LITRE

285547
type: SpeciesReference
stoichiometry: 1.0
species: 561235

285535
type: SpeciesReference
stoichiometry: 2.0
species: 563655

285523
type: SpeciesReference
stoichiometry: 1.0
species: 561075

561075
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 560175

569914
type: Reaction
kinetic law: 293736
product: 293724
product: 293712
reactant: 293700
fast: false
reversible: false

293736
type: KineticLaw
local parameters: 052259
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx

052259
type: LocalParameter
units: 284709
value: 1.8E-16

293724
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293712
type: SpeciesReference
stoichiometry: 1.0
species: 565175

293700
type: SpeciesReference
stoichiometry: 1.0
species: 562295

562295
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

564535
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00538592592592593
initial amount: NaN
in compartment: 560155

564135
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

570394
type: Reaction
kinetic law: 294898
product: 294886
product: 294874
reactant: 294862
fast: false
reversible: false

294898
type: KineticLaw
local parameters: 052341
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx

052341
type: LocalParameter
units: 284709
value: 5.4E-16

294886
type: SpeciesReference
stoichiometry: 1.0
species: 562655

294874
type: SpeciesReference
stoichiometry: 1.0
species: 564695

294862
type: SpeciesReference
stoichiometry: 1.0
species: 562735

567995
type: Reaction
kinetic law: 288695
product: 288682
product: 288670
reactant: 288658
fast: false
reversible: false

288695
type: KineticLaw
local parameters: 051930
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx

051930
type: LocalParameter
units: 284709
value: 5.0E-18

288682
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288670
type: SpeciesReference
stoichiometry: 1.0
species: 565115

288658
type: SpeciesReference
stoichiometry: 1.0
species: 560755

560755
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 560175

572534
type: Reaction
kinetic law: 300172
product: 300160
reactant: 300148
reactant: 300136
fast: false
reversible: true

300172
type: KineticLaw
local parameters: 052689
local parameters: 052686
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx

052689
type: LocalParameter
units: 284709
value: 6.8E-18

052686
type: LocalParameter
units: 284793
value: 8.7498E-18

300160
type: SpeciesReference
stoichiometry: 1.0
species: 564135

300148
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300136
type: SpeciesReference
stoichiometry: 1.0
species: 565175

568375
type: Reaction
kinetic law: 289616
product: 289604
reactant: 289592
reactant: 289580
fast: false
reversible: true

289616
type: KineticLaw
local parameters: 051984
local parameters: 051982
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD-k2*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx

051984
type: LocalParameter
units: 284709
value: 2.4E-16

051982
type: LocalParameter
units: 284793
value: 3.69594E-18

289604
type: SpeciesReference
stoichiometry: 1.0
species: 560955

560955
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

289592
type: SpeciesReference
stoichiometry: 1.0
species: 565615

289580
type: SpeciesReference
stoichiometry: 1.0
species: 560515

570194
type: Reaction
kinetic law: 294414
product: 294402
product: 294390
reactant: 294378
fast: false
reversible: false

294414
type: KineticLaw
local parameters: 052306
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx

052306
type: LocalParameter
units: 284709
value: 1.8E-16

294402
type: SpeciesReference
stoichiometry: 1.0
species: 561675

294390
type: SpeciesReference
stoichiometry: 1.0
species: 565015

294378
type: SpeciesReference
stoichiometry: 1.0
species: 562435

566975
type: Reaction
kinetic law: 286366
product: 286353
product: 286341
reactant: 286328
fast: false
reversible: true

286366
type: KineticLaw
local parameters: 051789
local parameters: 051787
notes: kf*PKA_slash_R2C_minus_cAMP4-kb*PKA_slash_PKA_minus_active*PKA_slash_R2_minus_cAMP4

051789
type: LocalParameter
units: 284793
value: 1.6199838E-15

051787
type: LocalParameter
units: 284709
value: 5.4E-15

286353
type: SpeciesReference
stoichiometry: 1.0
species: 562595

562595
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

286341
type: SpeciesReference
stoichiometry: 1.0
species: 562655

286328
type: SpeciesReference
stoichiometry: 1.0
species: 562575

562575
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

568875
type: Reaction
kinetic law: 290823
product: 290811
product: 290799
reactant: 290787
fast: false
reversible: false

290823
type: KineticLaw
local parameters: 052071
notes: k3*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx

052071
type: LocalParameter
units: 284709
value: 3.06E-18

290811
type: SpeciesReference
stoichiometry: 1.0
species: 561615

290799
type: SpeciesReference
stoichiometry: 1.0
species: 563675

563675
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 560175

290787
type: SpeciesReference
stoichiometry: 1.0
species: 561655

573414
type: Reaction
kinetic law: 302318
product: 302306
reactant: 302294
reactant: 302282
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

302318
type: KineticLaw
local parameters: 052857
local parameters: 052854
notes: k1*CaM_slash_neurogranin_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx

052857
type: LocalParameter
units: 284709
value: 2.106E-16

052854
type: LocalParameter
units: 284793
value: 1.020006E-18

302306
type: SpeciesReference
stoichiometry: 1.0
species: 564595

302294
type: SpeciesReference
stoichiometry: 1.0
species: 564515

564515
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 560155

302282
type: SpeciesReference
stoichiometry: 1.0
species: 561115

569434
type: Reaction
kinetic law: 292523
product: 292511
reactant: 292499
reactant: 292487
fast: false
reversible: true

292523
type: KineticLaw
local parameters: 052182
local parameters: 052179
notes: k1*AMPAR_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx

052182
type: LocalParameter
units: 284709
value: 7.2E-16

052179
type: LocalParameter
units: 284793
value: 1.8106416E-16

292511
type: SpeciesReference
stoichiometry: 1.0
species: 562035

292499
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292487
type: SpeciesReference
stoichiometry: 1.0
species: 564755

571614
type: Reaction
kinetic law: 297947
modifier: 297935
product: 297923
reactant: 297911
notes: 17 Feb 2005 Halved Vmax as the amount of enzyme has been doubled to get an integer value in the spine. 18 Feb 2005. Updated Km from BRENDA: EC No 4.6.1.1 Rat Km: 0.95 mM Turnover 12/sec. Human Km: 0.3 mM 12 umol/min/mg for mammalia, turnover is 12/sec See PMID 8663304 by Dessauer and Gilman JBC 271 1996 Unfortunately turnover range is from 34 down to 0.1 in different studies, according to BRENDA.
fast: false
reversible: false

297947
type: KineticLaw
local parameters: 052540
local parameters: 052537
notes: kcat*AC_slash_AC1_minus_CaM*AC_slash_ATP/(Km+AC_slash_ATP)

052540
type: LocalParameter
units: 284673
value: 299.9976000192

284697
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

284685
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

052537
type: LocalParameter
units: 284709
value: 4.05E-16

297923
type: SpeciesReference
stoichiometry: 1.0
species: 563635

297911
type: SpeciesReference
stoichiometry: 1.0
species: 565355

565355
type: Species
notes: ATP is present in all cells between 2 and 10 mM. See Lehninger
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2000.0
initial amount: NaN
in compartment: 560155

568735
type: Reaction
kinetic law: 290484
product: 290472
reactant: 290460
reactant: 290448
fast: false
reversible: true

290484
type: KineticLaw
local parameters: 052049
local parameters: 052047
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

052049
type: LocalParameter
units: 284709
value: 9.0E-16

052047
type: LocalParameter
units: 284793
value: 2.2062942E-16

290472
type: SpeciesReference
stoichiometry: 1.0
species: 561535

561535
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

290460
type: SpeciesReference
stoichiometry: 1.0
species: 561455

290448
type: SpeciesReference
stoichiometry: 1.0
species: 560295

572554
type: Reaction
kinetic law: 300220
product: 300208
product: 300196
reactant: 300184
fast: false
reversible: false

300220
type: KineticLaw
local parameters: 052690
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx

052690
type: LocalParameter
units: 284709
value: 1.7E-18

300208
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300196
type: SpeciesReference
stoichiometry: 1.0
species: 565000

300184
type: SpeciesReference
stoichiometry: 1.0
species: 564135

573474
type: Reaction
kinetic law: 302474
product: 302462
product: 302450
product: 302438
reactant: 302426
fast: false
reversible: false

302474
type: KineticLaw
local parameters: 052867
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx

052867
type: LocalParameter
units: 284709
value: 3.15E-17

302462
type: SpeciesReference
stoichiometry: 1.0
species: 564515

302450
type: SpeciesReference
stoichiometry: 1.0
species: 561135

561135
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

302438
type: SpeciesReference
stoichiometry: 1.0
species: 561075

302426
type: SpeciesReference
stoichiometry: 1.0
species: 564615

565435
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 560155

569494
type: Reaction
kinetic law: 292715
product: 292703
reactant: 292691
reactant: 292679
fast: false
reversible: true

292715
type: KineticLaw
local parameters: 052196
local parameters: 052193
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx

052196
type: LocalParameter
units: 284709
value: 7.2E-16

052193
type: LocalParameter
units: 284793
value: 1.8106416E-16

292703
type: SpeciesReference
stoichiometry: 1.0
species: 562075

562075
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

292691
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292679
type: SpeciesReference
stoichiometry: 1.0
species: 564795

564795
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

566515
type: Reaction
kinetic law: 285278
product: 285265
reactant: 285253
reactant: 285241
fast: false
reversible: true

285278
type: KineticLaw
local parameters: 051720
local parameters: 051718
notes: kf*CaMKII_slash_CaMKII_minus_PSD*CaM_slash_CaM_minus_Ca4_minus_PSD-kb*CaMKII_slash_CaMKII_minus_CaM_minus_PSD

051720
type: LocalParameter
units: 284709
value: 0.0

051718
type: LocalParameter
units: 284793
value: 4.99998E-16

285265
type: SpeciesReference
stoichiometry: 1.0
species: 560535

560535
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

285253
type: SpeciesReference
stoichiometry: 1.0
species: 561195

285241
type: SpeciesReference
stoichiometry: 1.0
species: 560475

560475
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

573054
type: Reaction
kinetic law: 301430
product: 301418
reactant: 301405
reactant: 301393
fast: false
reversible: true

301430
type: KineticLaw
local parameters: 052778
local parameters: 052775
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx

052778
type: LocalParameter
units: 284709
value: 1.4E-17

052775
type: LocalParameter
units: 284793
value: 8.7498E-18

301418
type: SpeciesReference
stoichiometry: 1.0
species: 564395

564395
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

301405
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301393
type: SpeciesReference
stoichiometry: 1.0
species: 565015

572974
type: Reaction
kinetic law: 301236
product: 301224
reactant: 301212
reactant: 301200
fast: false
reversible: true

301236
type: KineticLaw
local parameters: 052762
local parameters: 052759
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx

052762
type: LocalParameter
units: 284709
value: 1.4E-17

052759
type: LocalParameter
units: 284793
value: 8.7498E-18

301224
type: SpeciesReference
stoichiometry: 1.0
species: 564355

564355
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

301212
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301200
type: SpeciesReference
stoichiometry: 1.0
species: 565195

567815
type: Reaction
kinetic law: 288260
product: 288248
reactant: 288236
reactant: 288224
fast: false
reversible: true

288260
type: KineticLaw
local parameters: 051908
local parameters: 051906
notes: k1*AMPAR_memb_slash_A845_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx

051908
type: LocalParameter
units: 284709
value: 2.0E-17

051906
type: LocalParameter
units: 284793
value: 2.77776E-19

288248
type: SpeciesReference
stoichiometry: 1.0
species: 560675

288236
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288224
type: SpeciesReference
stoichiometry: 1.0
species: 565035

568755
type: Reaction
kinetic law: 290532
product: 290520
product: 290508
reactant: 290496
fast: false
reversible: false

290532
type: KineticLaw
local parameters: 052052
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

052052
type: LocalParameter
units: 284709
value: 2.25E-16

290520
type: SpeciesReference
stoichiometry: 1.0
species: 561455

290508
type: SpeciesReference
stoichiometry: 1.0
species: 560415

290496
type: SpeciesReference
stoichiometry: 1.0
species: 561535

560595
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

568475
type: Reaction
kinetic law: 289857
product: 289844
product: 289832
reactant: 289820
fast: false
reversible: false

289857
type: KineticLaw
local parameters: 052003
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx

052003
type: LocalParameter
units: 284709
value: 1.8E-16

289844
type: SpeciesReference
stoichiometry: 1.0
species: 561355

289832
type: SpeciesReference
stoichiometry: 1.0
species: 561275

289820
type: SpeciesReference
stoichiometry: 1.0
species: 561375

561375
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.99333333333333E-6
initial amount: NaN
in compartment: 560155

570977
type: Reaction
kinetic law: 296297
product: 296285
reactant: 296273
reactant: 296261
fast: false
reversible: true

296297
type: KineticLaw
local parameters: 052432
local parameters: 052429
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx

052432
type: LocalParameter
units: 284709
value: 2.16E-15

052429
type: LocalParameter
units: 284793
value: 3.5998992E-16

296285
type: SpeciesReference
stoichiometry: 1.0
species: 563035

296273
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296261
type: SpeciesReference
stoichiometry: 1.0
species: 564935

573074
type: Reaction
kinetic law: 301478
product: 301466
product: 301454
reactant: 301442
fast: false
reversible: false

301478
type: KineticLaw
local parameters: 052779
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx

052779
type: LocalParameter
units: 284709
value: 3.5E-18

301466
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301454
type: SpeciesReference
stoichiometry: 1.0
species: 565000

301442
type: SpeciesReference
stoichiometry: 1.0
species: 564395

567875
type: Reaction
kinetic law: 288405
product: 288393
product: 288381
reactant: 288369
fast: false
reversible: false

288405
type: KineticLaw
local parameters: 051915
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx

051915
type: LocalParameter
units: 284709
value: 5.0E-18

288393
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288381
type: SpeciesReference
stoichiometry: 1.0
species: 564995

288369
type: SpeciesReference
stoichiometry: 1.0
species: 560695

560695
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 560175

568275
type: Reaction
kinetic law: 289374
product: 289362
product: 289350
reactant: 289337
fast: false
reversible: false

289374
type: KineticLaw
local parameters: 051967
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx

051967
type: LocalParameter
units: 284709
value: 5.0E-18

289362
type: SpeciesReference
stoichiometry: 1.0
species: 565595

289350
type: SpeciesReference
stoichiometry: 1.0
species: 565195

289337
type: SpeciesReference
stoichiometry: 1.0
species: 560895

560895
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 560175

573354
type: Reaction
kinetic law: 302174
product: 302162
product: 302150
product: 302138
reactant: 302126
fast: false
reversible: false

302174
type: KineticLaw
local parameters: 052842
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx

052842
type: LocalParameter
units: 284709
value: 3.15E-17

302162
type: SpeciesReference
stoichiometry: 1.0
species: 564515

302150
type: SpeciesReference
stoichiometry: 1.0
species: 561035

302138
type: SpeciesReference
stoichiometry: 1.0
species: 560995

302126
type: SpeciesReference
stoichiometry: 1.0
species: 564555

564555
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

569154
type: Reaction
kinetic law: 291548
product: 291536
reactant: 291524
reactant: 291512
fast: false
reversible: true

291548
type: KineticLaw
local parameters: 052118
local parameters: 052115
notes: k1*AMPAR_slash_A845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx

052118
type: LocalParameter
units: 284709
value: 7.2E-16

052115
type: LocalParameter
units: 284793
value: 1.8106416E-16

291536
type: SpeciesReference
stoichiometry: 1.0
species: 561835

561835
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

291524
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291512
type: SpeciesReference
stoichiometry: 1.0
species: 564895

569314
type: Reaction
kinetic law: 292128
product: 292116
reactant: 292103
reactant: 292091
fast: false
reversible: true

292128
type: KineticLaw
local parameters: 052156
local parameters: 052153
notes: k1*AMPAR_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx

052156
type: LocalParameter
units: 284709
value: 7.2E-16

052153
type: LocalParameter
units: 284793
value: 1.8106416E-16

292116
type: SpeciesReference
stoichiometry: 1.0
species: 561955

561955
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

292103
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292091
type: SpeciesReference
stoichiometry: 1.0
species: 564755

570794
type: Reaction
kinetic law: 295864
product: 295851
product: 295839
reactant: 295827
fast: false
reversible: false

295864
type: KineticLaw
local parameters: 052403
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx

052403
type: LocalParameter
units: 284709
value: 5.4E-16

295851
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295839
type: SpeciesReference
stoichiometry: 1.0
species: 564795

295827
type: SpeciesReference
stoichiometry: 1.0
species: 562935

562935
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

565555
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 560175

569814
type: Reaction
kinetic law: 293493
product: 293480
reactant: 293468
reactant: 293456
fast: false
reversible: true

293493
type: KineticLaw
local parameters: 052246
local parameters: 052243
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx

052246
type: LocalParameter
units: 284709
value: 7.2E-16

052243
type: LocalParameter
units: 284793
value: 2.011824E-17

293480
type: SpeciesReference
stoichiometry: 1.0
species: 562255

562255
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

293468
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293456
type: SpeciesReference
stoichiometry: 1.0
species: 565155

571134
type: Reaction
kinetic law: 296780
product: 296768
reactant: 296756
reactant: 296744
fast: false
reversible: true

296780
type: KineticLaw
local parameters: 052463
local parameters: 052460
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx

052463
type: LocalParameter
units: 284709
value: 2.16E-15

052460
type: LocalParameter
units: 284793
value: 3.999888E-17

296768
type: SpeciesReference
stoichiometry: 1.0
species: 563135

296756
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296744
type: SpeciesReference
stoichiometry: 1.0
species: 565155

567395
type: Reaction
kinetic law: 287285
product: 287273
reactant: 287260
notes: Represents both synthesis and degradation of the receptor. The rate is set to be rather fast for now. The forward rate also includes scaling terms because the AMPAR_bulk is in the dendritic volume of 5e-18. This means that we need to lower Kf to account for the difference in volumes. Effectively Kf is 1/sec, but the scaled version becomes 9e-20/5e-18 = 0.018
fast: false
reversible: true

287285
type: KineticLaw
local parameters: 051852
local parameters: 051850
notes: kf*AMPAR_slash_AMPAR_bulk-kb*AMPAR_slash_A_B

051852
type: LocalParameter
units: 284709
value: 9.0E-17

051850
type: LocalParameter
units: 284709
value: 9.0E-17

287273
type: SpeciesReference
stoichiometry: 1.0
species: 564655

287260
type: SpeciesReference
stoichiometry: 1.0
species: 565395

565395
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.011111
initial amount: NaN
in compartment: 560195

571554
type: Reaction
kinetic law: 297803
product: 297791
product: 297779
reactant: 297767
fast: false
reversible: false

297803
type: KineticLaw
local parameters: 052529
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx

052529
type: LocalParameter
units: 284709
value: 5.4E-16

297791
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297779
type: SpeciesReference
stoichiometry: 1.0
species: 565195

297767
type: SpeciesReference
stoichiometry: 1.0
species: 563335

563335
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

570294
type: Reaction
kinetic law: 294658
product: 294645
reactant: 294633
reactant: 294621
notes: #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
fast: false
reversible: true

294658
type: KineticLaw
local parameters: 052326
local parameters: 052323
notes: k1*PP1_slash_I1*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx

052326
type: LocalParameter
units: 284709
value: 3.24E-15

052323
type: LocalParameter
units: 284793
value: 5.399946E-16

294645
type: SpeciesReference
stoichiometry: 1.0
species: 562695

294633
type: SpeciesReference
stoichiometry: 1.0
species: 562655

294621
type: SpeciesReference
stoichiometry: 1.0
species: 561275

572014
type: Reaction
kinetic law: 298915
product: 298903
reactant: 298891
reactant: 298879
fast: false
reversible: true

298915
type: KineticLaw
local parameters: 052603
local parameters: 052600
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx

052603
type: LocalParameter
units: 284709
value: 6.8E-18

052600
type: LocalParameter
units: 284793
value: 8.7498E-18

298903
type: SpeciesReference
stoichiometry: 1.0
species: 563875

563875
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

298891
type: SpeciesReference
stoichiometry: 1.0
species: 563755

298879
type: SpeciesReference
stoichiometry: 1.0
species: 565135

568675
type: Reaction
kinetic law: 290339
product: 290327
product: 290315
reactant: 290303
fast: false
reversible: false

290339
type: KineticLaw
local parameters: 052036
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

052036
type: LocalParameter
units: 284709
value: 2.25E-16

290327
type: SpeciesReference
stoichiometry: 1.0
species: 561455

290315
type: SpeciesReference
stoichiometry: 1.0
species: 560235

290303
type: SpeciesReference
stoichiometry: 1.0
species: 561495

561495
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

572434
type: Reaction
kinetic law: 299932
product: 299920
product: 299908
reactant: 299896
fast: false
reversible: false

299932
type: KineticLaw
local parameters: 052669
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx

052669
type: LocalParameter
units: 284709
value: 3.5E-18

299920
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299908
type: SpeciesReference
stoichiometry: 1.0
species: 564975

299896
type: SpeciesReference
stoichiometry: 1.0
species: 564075

570094
type: Reaction
kinetic law: 294172
product: 294160
reactant: 294147
reactant: 294135
fast: false
reversible: true

294172
type: KineticLaw
local parameters: 052291
local parameters: 052288
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx

052291
type: LocalParameter
units: 284709
value: 7.2E-16

052288
type: LocalParameter
units: 284793
value: 2.011824E-17

294160
type: SpeciesReference
stoichiometry: 1.0
species: 562395

562395
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

294147
type: SpeciesReference
stoichiometry: 1.0
species: 561675

294135
type: SpeciesReference
stoichiometry: 1.0
species: 565255

571754
type: Reaction
kinetic law: 298284
product: 298272
product: 298260
reactant: 298248
fast: false
reversible: false

298284
type: KineticLaw
local parameters: 052559
notes: k3*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx

052559
type: LocalParameter
units: 284709
value: 1.5003E-16

298272
type: SpeciesReference
stoichiometry: 1.0
species: 563535

298260
type: SpeciesReference
stoichiometry: 1.0
species: 563435

298248
type: SpeciesReference
stoichiometry: 1.0
species: 563555

569374
type: Reaction
kinetic law: 292323
product: 292310
reactant: 292297
reactant: 292285
fast: false
reversible: true

292323
type: KineticLaw
local parameters: 052169
local parameters: 052166
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx

052169
type: LocalParameter
units: 284709
value: 7.2E-16

052166
type: LocalParameter
units: 284793
value: 1.8106416E-16

292310
type: SpeciesReference
stoichiometry: 1.0
species: 561995

561995
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

292297
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292285
type: SpeciesReference
stoichiometry: 1.0
species: 564795

569794
type: Reaction
kinetic law: 293444
product: 293432
product: 293420
reactant: 293408
fast: false
reversible: false

293444
type: KineticLaw
local parameters: 052241
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx

052241
type: LocalParameter
units: 284709
value: 1.8E-16

293432
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293420
type: SpeciesReference
stoichiometry: 1.0
species: 565055

293408
type: SpeciesReference
stoichiometry: 1.0
species: 562235

562235
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

567755
type: Reaction
kinetic law: 288116
product: 288104
product: 288092
reactant: 288080
fast: false
reversible: false

288116
type: KineticLaw
local parameters: 051899
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx

051899
type: LocalParameter
units: 284709
value: 5.0E-18

288104
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288092
type: SpeciesReference
stoichiometry: 1.0
species: 565215

288080
type: SpeciesReference
stoichiometry: 1.0
species: 560635

560635
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 560175

572494
type: Reaction
kinetic law: 300076
product: 300064
reactant: 300052
reactant: 300040
fast: false
reversible: true

300076
type: KineticLaw
local parameters: 052683
local parameters: 052680
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx

052683
type: LocalParameter
units: 284709
value: 6.8E-18

052680
type: LocalParameter
units: 284793
value: 8.7498E-18

300064
type: SpeciesReference
stoichiometry: 1.0
species: 564115

564115
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

300052
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300040
type: SpeciesReference
stoichiometry: 1.0
species: 565235

567335
type: Reaction
kinetic law: 287151
product: 287139
reactant: 287127
reactant: 287115
fast: false
reversible: true

287151
type: KineticLaw
local parameters: 051843
local parameters: 051841
notes: kf*AMPAR_slash_A845_star__B831_star_845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A845_star__B831_star_845_star_

051843
type: LocalParameter
units: 284709
value: 8.0E-20

051841
type: LocalParameter
units: 284793
value: 1.08E-19

287139
type: SpeciesReference
stoichiometry: 1.0
species: 565235

287127
type: SpeciesReference
stoichiometry: 1.0
species: 565295

287115
type: SpeciesReference
stoichiometry: 1.0
species: 564795

562895
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

566995
type: Reaction
kinetic law: 286415
product: 286403
reactant: 286391
reactant: 286378
notes: This has to be set to zero for matching the expts in vitro. In vivo we need to consider the inhibition though. kf = 1e-5 kb = 1
fast: false
reversible: true

286415
type: KineticLaw
local parameters: 051792
local parameters: 051790
notes: kf*PKA_slash_PKA_minus_active*PKA_slash_PKA_minus_inhibitor-kb*PKA_slash_inhibited_minus_PKA

051792
type: LocalParameter
units: 284709
value: 9.0E-17

051790
type: LocalParameter
units: 284793
value: 5.399946E-15

286403
type: SpeciesReference
stoichiometry: 1.0
species: 562635

562635
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

286391
type: SpeciesReference
stoichiometry: 1.0
species: 562615

286378
type: SpeciesReference
stoichiometry: 1.0
species: 562655

566415
type: Reaction
kinetic law: 285047
product: 285034
product: 285022
reactant: 285010
notes: Rates set by the translocation experiments of Shen and Meyer, Science 1999.
fast: false
reversible: true

285047
type: KineticLaw
local parameters: 051705
local parameters: 051703
notes: kf*CaMKII_slash_CaMKII_minus_PSD-kb*CaMKII_slash_CaMKII*CaMKII_slash_NMDAR

051705
type: LocalParameter
units: 284793
value: 5.4E-21

051703
type: LocalParameter
units: 284709
value: 3.0E-18

285034
type: SpeciesReference
stoichiometry: 1.0
species: 560495

285022
type: SpeciesReference
stoichiometry: 1.0
species: 560235

285010
type: SpeciesReference
stoichiometry: 1.0
species: 560475

568195
type: Reaction
kinetic law: 289181
product: 289168
product: 289156
reactant: 289144
fast: false
reversible: false

289181
type: KineticLaw
local parameters: 051957
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx

051957
type: LocalParameter
units: 284709
value: 5.0E-18

289168
type: SpeciesReference
stoichiometry: 1.0
species: 565595

289156
type: SpeciesReference
stoichiometry: 1.0
species: 565015

289144
type: SpeciesReference
stoichiometry: 1.0
species: 560855

565795
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

568355
type: Reaction
kinetic law: 289568
product: 289556
product: 289544
reactant: 289532
fast: false
reversible: false

289568
type: KineticLaw
local parameters: 051979
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx

051979
type: LocalParameter
units: 284709
value: 5.0E-18

289556
type: SpeciesReference
stoichiometry: 1.0
species: 565595

289544
type: SpeciesReference
stoichiometry: 1.0
species: 565015

289532
type: SpeciesReference
stoichiometry: 1.0
species: 560935

560935
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 560175

561775
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

569195
type: Reaction
kinetic law: 291693
product: 291681
product: 291669
reactant: 291657
fast: false
reversible: false

291693
type: KineticLaw
local parameters: 052125
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx

052125
type: LocalParameter
units: 284709
value: 1.8E-16

291681
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291669
type: SpeciesReference
stoichiometry: 1.0
species: 564915

291657
type: SpeciesReference
stoichiometry: 1.0
species: 561855

561855
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

567275
type: Reaction
kinetic law: 287018
product: 287006
reactant: 286994
fast: false
reversible: true

287018
type: KineticLaw
local parameters: 051834
local parameters: 051832
notes: kf*AMPAR_slash_A831_star_845_star__B845_star_-kb*AMPAR_slash_AMPAR_deg

051834
type: LocalParameter
units: 284709
value: 0.0

051832
type: LocalParameter
units: 284709
value: 3.24E-21

287006
type: SpeciesReference
stoichiometry: 1.0
species: 565375

565375
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

286994
type: SpeciesReference
stoichiometry: 1.0
species: 564775

570995
type: Reaction
kinetic law: 296394
product: 296382
reactant: 296370
reactant: 296358
fast: false
reversible: true

296394
type: KineticLaw
local parameters: 052438
local parameters: 052435
notes: k1*AMPAR_memb_slash_A_B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_slash_PKA_cplx

052438
type: LocalParameter
units: 284709
value: 2.16E-15

052435
type: LocalParameter
units: 284793
value: 3.999888E-17

296382
type: SpeciesReference
stoichiometry: 1.0
species: 563055

563055
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

296370
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296358
type: SpeciesReference
stoichiometry: 1.0
species: 565095

570994
type: Reaction
kinetic law: 296346
product: 296334
product: 296321
reactant: 296309
fast: false
reversible: false

296346
type: KineticLaw
local parameters: 052433
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx

052433
type: LocalParameter
units: 284709
value: 5.4E-16

296334
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296321
type: SpeciesReference
stoichiometry: 1.0
species: 564815

296309
type: SpeciesReference
stoichiometry: 1.0
species: 563035

572314
type: Reaction
kinetic law: 299640
product: 299628
product: 299616
reactant: 299604
fast: false
reversible: false

299640
type: KineticLaw
local parameters: 052650
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx

052650
type: LocalParameter
units: 284709
value: 3.5E-18

299628
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299616
type: SpeciesReference
stoichiometry: 1.0
species: 565135

299604
type: SpeciesReference
stoichiometry: 1.0
species: 564015

564015
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

571634
type: Reaction
kinetic law: 297995
modifier: 297983
product: 297971
reactant: 297959
notes: Reduced Km to match expt data for basal activation of AC2 by PKC. Now k1 = 2.9e-6, k2 = 72, k3 = 18 18 Feb: Raised Km to 300 based on BRENDA data. Unlikely to make much difference, given the vast amount of ATP.
fast: false
reversible: false

297995
type: KineticLaw
local parameters: 052543
local parameters: 052541
notes: kcat*AC_slash_AC2_star_*AC_slash_ATP/(Km+AC_slash_ATP)

052543
type: LocalParameter
units: 284673
value: 300.001920012288

052541
type: LocalParameter
units: 284709
value: 1.8E-16

563395
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

297971
type: SpeciesReference
stoichiometry: 1.0
species: 563635

297959
type: SpeciesReference
stoichiometry: 1.0
species: 565355

561635
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

562195
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

569254
type: Reaction
kinetic law: 291837
product: 291825
reactant: 291813
reactant: 291801
fast: false
reversible: true

291837
type: KineticLaw
local parameters: 052137
local parameters: 052134
notes: k1*AMPAR_slash_A831_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx

052137
type: LocalParameter
units: 284709
value: 7.2E-16

052134
type: LocalParameter
units: 284793
value: 1.8106416E-16

291825
type: SpeciesReference
stoichiometry: 1.0
species: 561895

291813
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291801
type: SpeciesReference
stoichiometry: 1.0
species: 564955

570674
type: Reaction
kinetic law: 295573
product: 295561
product: 295548
reactant: 295536
fast: false
reversible: false

295573
type: KineticLaw
local parameters: 052385
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx

052385
type: LocalParameter
units: 284709
value: 5.4E-16

295561
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295548
type: SpeciesReference
stoichiometry: 1.0
species: 564855

295536
type: SpeciesReference
stoichiometry: 1.0
species: 562875

562875
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

571014
type: Reaction
kinetic law: 296442
product: 296430
product: 296418
reactant: 296406
fast: false
reversible: false

296442
type: KineticLaw
local parameters: 052439
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_slash_PKA_cplx

052439
type: LocalParameter
units: 284709
value: 5.4E-16

296430
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296418
type: SpeciesReference
stoichiometry: 1.0
species: 565135

296406
type: SpeciesReference
stoichiometry: 1.0
species: 563055

560835
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 560175

569514
type: Reaction
kinetic law: 292764
product: 292752
product: 292739
reactant: 292727
fast: false
reversible: false

292764
type: KineticLaw
local parameters: 052197
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx

052197
type: LocalParameter
units: 284709
value: 1.8E-16

292752
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292739
type: SpeciesReference
stoichiometry: 1.0
species: 564895

292727
type: SpeciesReference
stoichiometry: 1.0
species: 562075

560215
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 560155

571434
type: Reaction
kinetic law: 297513
product: 297501
product: 297488
reactant: 297476
fast: false
reversible: false

297513
type: KineticLaw
local parameters: 052510
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx

052510
type: LocalParameter
units: 284709
value: 5.4E-16

297501
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297488
type: SpeciesReference
stoichiometry: 1.0
species: 565115

297476
type: SpeciesReference
stoichiometry: 1.0
species: 563275

572374
type: Reaction
kinetic law: 299787
product: 299774
reactant: 299762
reactant: 299749
fast: false
reversible: true

299787
type: KineticLaw
local parameters: 052661
local parameters: 052658
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx

052661
type: LocalParameter
units: 284709
value: 1.4E-17

052658
type: LocalParameter
units: 284793
value: 8.7498E-18

299774
type: SpeciesReference
stoichiometry: 1.0
species: 564055

564055
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

299762
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299749
type: SpeciesReference
stoichiometry: 1.0
species: 565055

568555
type: Reaction
kinetic law: 290049
product: 290037
product: 290025
reactant: 290013
fast: false
reversible: false

290049
type: KineticLaw
local parameters: 052015
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx

052015
type: LocalParameter
units: 284709
value: 1.8E-16

290037
type: SpeciesReference
stoichiometry: 1.0
species: 561355

290025
type: SpeciesReference
stoichiometry: 1.0
species: 563675

290013
type: SpeciesReference
stoichiometry: 1.0
species: 561415

561415
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.21555555555556E-7
initial amount: NaN
in compartment: 560155

573394
type: Reaction
kinetic law: 302270
product: 302258
product: 302246
reactant: 302234
fast: false
reversible: false

302270
type: KineticLaw
local parameters: 052851
notes: k3*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx

052851
type: LocalParameter
units: 284709
value: 3.6E-16

302258
type: SpeciesReference
stoichiometry: 1.0
species: 564515

302246
type: SpeciesReference
stoichiometry: 1.0
species: 563395

302234
type: SpeciesReference
stoichiometry: 1.0
species: 564575

564575
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.00703703703704E-5
initial amount: NaN
in compartment: 560155

569075
type: Reaction
kinetic law: 291308
product: 291296
product: 291284
reactant: 291272
fast: false
reversible: false

291308
type: KineticLaw
local parameters: 052101
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx

052101
type: LocalParameter
units: 284709
value: 3.06E-17

291296
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291284
type: SpeciesReference
stoichiometry: 1.0
species: 563735

291272
type: SpeciesReference
stoichiometry: 1.0
species: 561775

563235
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

567695
type: Reaction
kinetic law: 287971
product: 287959
reactant: 287947
reactant: 287934
fast: false
reversible: true

287971
type: KineticLaw
local parameters: 051893
local parameters: 051891
notes: k1*CaMKII_slash_CaMKII_minus_CaM_minus_PSD*CaMKII_slash_tot_minus_auto_minus_PSD-k2*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx

051893
type: LocalParameter
units: 284709
value: 2.0E-17

051891
type: LocalParameter
units: 284793
value: 1.99998E-19

287959
type: SpeciesReference
stoichiometry: 1.0
species: 560595

287947
type: SpeciesReference
stoichiometry: 1.0
species: 565555

287934
type: SpeciesReference
stoichiometry: 1.0
species: 560535

562455
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

562055
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

573374
type: Reaction
kinetic law: 302222
product: 302210
reactant: 302198
reactant: 302186
notes: Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4
fast: false
reversible: true

302222
type: KineticLaw
local parameters: 052848
local parameters: 052845
notes: k1*AC_slash_AC2*PKC_minus_active-k2*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx

052848
type: LocalParameter
units: 284709
value: 1.44E-15

052845
type: LocalParameter
units: 284793
value: 5.399946E-17

302210
type: SpeciesReference
stoichiometry: 1.0
species: 564575

302198
type: SpeciesReference
stoichiometry: 1.0
species: 564515

302186
type: SpeciesReference
stoichiometry: 1.0
species: 563415

563415
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 560155

570254
type: Reaction
kinetic law: 294560
product: 294548
reactant: 294536
reactant: 294524
notes: Same rates as PKA-phosph-I1
fast: false
reversible: true

294560
type: KineticLaw
local parameters: 052319
local parameters: 052316
notes: k1*AC_slash_cAMP_minus_PDE*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx

052319
type: LocalParameter
units: 284709
value: 3.24E-15

052316
type: LocalParameter
units: 284793
value: 5.399946E-16

294548
type: SpeciesReference
stoichiometry: 1.0
species: 562675

294536
type: SpeciesReference
stoichiometry: 1.0
species: 562655

294524
type: SpeciesReference
stoichiometry: 1.0
species: 563455

562475
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: 560155

566875
type: Reaction
kinetic law: 286121
product: 286109
reactant: 286097
reactant: 286084
notes: Hasler et al FASEB J 6:2734-2741 1992 say Kd =1e-7M for type II, 5.6e-8 M for type I. Take mean which comes to 2e-13 #/cell Smith et al PNAS USA 78:3 1591-1595 1981 have better data. First kf/kb=2.1e7/M = 3.5e-5 (#/cell). Ogreid and Doskeland Febs Lett 129:2 287-292 1981 have figs suggesting time course of complete assoc is < 1 min.
fast: false
reversible: true

286121
type: KineticLaw
local parameters: 051774
local parameters: 051772
notes: kf*PKA_slash_R2C2*AC_slash_cAMP-kb*PKA_slash_R2C2_minus_cAMP

051774
type: LocalParameter
units: 284709
value: 2.97E-15

051772
type: LocalParameter
units: 284793
value: 4.86E-15

286109
type: SpeciesReference
stoichiometry: 1.0
species: 562495

562495
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

286097
type: SpeciesReference
stoichiometry: 1.0
species: 563635

286084
type: SpeciesReference
stoichiometry: 1.0
species: 562475

561475
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

570154
type: Reaction
kinetic law: 294318
product: 294306
product: 294294
reactant: 294281
fast: false
reversible: false

294318
type: KineticLaw
local parameters: 052299
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx

052299
type: LocalParameter
units: 284709
value: 1.8E-16

294306
type: SpeciesReference
stoichiometry: 1.0
species: 561675

294294
type: SpeciesReference
stoichiometry: 1.0
species: 565015

294281
type: SpeciesReference
stoichiometry: 1.0
species: 562415

571574
type: Reaction
kinetic law: 297851
product: 297839
reactant: 297827
reactant: 297815
fast: false
reversible: true

297851
type: KineticLaw
local parameters: 052534
local parameters: 052531
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx

052534
type: LocalParameter
units: 284709
value: 2.16E-15

052531
type: LocalParameter
units: 284793
value: 3.999888E-17

297839
type: SpeciesReference
stoichiometry: 1.0
species: 563355

563355
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

297827
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297815
type: SpeciesReference
stoichiometry: 1.0
species: 565015

568695
type: Reaction
kinetic law: 290387
product: 290375
reactant: 290363
reactant: 290351
fast: false
reversible: true

290387
type: KineticLaw
local parameters: 052041
local parameters: 052039
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

052041
type: LocalParameter
units: 284709
value: 9.0E-16

052039
type: LocalParameter
units: 284793
value: 2.2062942E-16

290375
type: SpeciesReference
stoichiometry: 1.0
species: 561515

561515
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

290363
type: SpeciesReference
stoichiometry: 1.0
species: 561455

290351
type: SpeciesReference
stoichiometry: 1.0
species: 560295

567375
type: Reaction
kinetic law: 287248
product: 287236
reactant: 287224
reactant: 287212
notes: Exo rates are scaled from earlier model versions to account for binding of anchor. We have about 200 molecules of anchor in the whole model. Here we select rates to give us a max of about 150 molecules of GluR at the synapse.
fast: false
reversible: true

287248
type: KineticLaw
local parameters: 051849
local parameters: 051847
notes: kf*AMPAR_slash_A845_star__B845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A845_star__B845_star_

051849
type: LocalParameter
units: 284709
value: 8.0E-20

051847
type: LocalParameter
units: 284793
value: 1.08E-19

287236
type: SpeciesReference
stoichiometry: 1.0
species: 565135

287224
type: SpeciesReference
stoichiometry: 1.0
species: 565295

287212
type: SpeciesReference
stoichiometry: 1.0
species: 564755

284853
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

571994
type: Reaction
kinetic law: 298867
product: 298855
product: 298843
reactant: 298830
fast: false
reversible: false

298867
type: KineticLaw
local parameters: 052598
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx

052598
type: LocalParameter
units: 284709
value: 1.7E-18

298855
type: SpeciesReference
stoichiometry: 1.0
species: 563755

298843
type: SpeciesReference
stoichiometry: 1.0
species: 565095

298830
type: SpeciesReference
stoichiometry: 1.0
species: 563855

573014
type: Reaction
kinetic law: 301332
product: 301320
reactant: 301308
reactant: 301296
fast: false
reversible: true

301332
type: KineticLaw
local parameters: 052769
local parameters: 052766
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx

052769
type: LocalParameter
units: 284709
value: 1.4E-17

052766
type: LocalParameter
units: 284793
value: 8.7498E-18

301320
type: SpeciesReference
stoichiometry: 1.0
species: 564375

564375
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

301308
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301296
type: SpeciesReference
stoichiometry: 1.0
species: 565075

567775
type: Reaction
kinetic law: 288164
product: 288152
reactant: 288140
reactant: 288128
fast: false
reversible: true

288164
type: KineticLaw
local parameters: 051903
local parameters: 051901
notes: k1*AMPAR_memb_slash_A_B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx

051903
type: LocalParameter
units: 284709
value: 2.0E-17

051901
type: LocalParameter
units: 284793
value: 2.77776E-19

288152
type: SpeciesReference
stoichiometry: 1.0
species: 560655

288140
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288128
type: SpeciesReference
stoichiometry: 1.0
species: 565095

566755
type: Reaction
kinetic law: 285827
product: 285815
reactant: 285803
notes: Diffusional equilibrium between PSD- and cytosolic compartment. According to D. Bary in Cell Movements 2nd ed 2001 D for proteins is 5e-7 cm^2/s giving 10 ms for a translocation of 1 um.
fast: false
reversible: true

285827
type: KineticLaw
local parameters: 051756
local parameters: 051754
notes: kf*CaM_slash_CaM_minus_Ca4_minus_PSD-kb*CaM_slash_CaM_minus_Ca4

051756
type: LocalParameter
units: 284709
value: 5.4E-15

051754
type: LocalParameter
units: 284709
value: 5.4E-15

285815
type: SpeciesReference
stoichiometry: 1.0
species: 561255

285803
type: SpeciesReference
stoichiometry: 1.0
species: 561195

561175
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

567575
type: Reaction
kinetic law: 287681
product: 287669
reactant: 287657
reactant: 287645
notes: See Hanson and Schulman again, for afterburst rates of phosph.
fast: false
reversible: true

287681
type: KineticLaw
local parameters: 051878
local parameters: 051876
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx

051878
type: LocalParameter
units: 284709
value: 2.16E-15

051876
type: LocalParameter
units: 284793
value: 1.5428556E-17

287669
type: SpeciesReference
stoichiometry: 1.0
species: 560375

560375
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.90055555555556E-8
initial amount: NaN
in compartment: 560155

287657
type: SpeciesReference
stoichiometry: 1.0
species: 565495

287645
type: SpeciesReference
stoichiometry: 1.0
species: 560315

560315
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

563775
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

567295
type: Reaction
kinetic law: 287054
product: 287042
reactant: 287030
fast: false
reversible: true

287054
type: KineticLaw
local parameters: 051837
local parameters: 051835
notes: kf*AMPAR_slash_A845_star__B845_star_-kb*AMPAR_slash_AMPAR_deg

051837
type: LocalParameter
units: 284709
value: 0.0

051835
type: LocalParameter
units: 284709
value: 3.24E-21

287042
type: SpeciesReference
stoichiometry: 1.0
species: 565375

287030
type: SpeciesReference
stoichiometry: 1.0
species: 564755

567095
type: Reaction
kinetic law: 286620
product: 286608
reactant: 286596
notes: Represents diffusion, from a volume of 9e-20 to 5e-18. Assuming neck dimensions of 0.1 x 0.1 microns, this works out to a diffusion const of about 270 um^2/sec, which is pretty conservative. It is what cAMP does in frog cilia.
fast: false
reversible: true

286620
type: KineticLaw
local parameters: 051807
local parameters: 051805
notes: kf*AC_slash_cAMP-kb*AC_slash_cAMP_in_dend

051807
type: LocalParameter
units: 284709
value: 2.7E-14

051805
type: LocalParameter
units: 284709
value: 2.7E-14

286608
type: SpeciesReference
stoichiometry: 1.0
species: 563615

286596
type: SpeciesReference
stoichiometry: 1.0
species: 563635

571934
type: Reaction
kinetic law: 298722
product: 298710
reactant: 298698
reactant: 298686
fast: false
reversible: true

298722
type: KineticLaw
local parameters: 052591
local parameters: 052588
notes: k1*CaMKII_slash_CaMKII_star__star__star__minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

052591
type: LocalParameter
units: 284709
value: 1.0E-16

052588
type: LocalParameter
units: 284793
value: 6.2502E-17

298710
type: SpeciesReference
stoichiometry: 1.0
species: 563835

563835
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

298698
type: SpeciesReference
stoichiometry: 1.0
species: 563755

298686
type: SpeciesReference
stoichiometry: 1.0
species: 560455

564095
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

572794
type: Reaction
kinetic law: 300801
product: 300789
product: 300777
reactant: 300765
fast: false
reversible: false

300801
type: KineticLaw
local parameters: 052730
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx

052730
type: LocalParameter
units: 284709
value: 3.5E-18

300789
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300777
type: SpeciesReference
stoichiometry: 1.0
species: 565095

300765
type: SpeciesReference
stoichiometry: 1.0
species: 564255

569274
type: Reaction
kinetic law: 291935
product: 291922
reactant: 291910
reactant: 291898
fast: false
reversible: true

291935
type: KineticLaw
local parameters: 052143
local parameters: 052140
notes: k1*AMPAR_slash_A_B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx

052143
type: LocalParameter
units: 284709
value: 7.2E-16

052140
type: LocalParameter
units: 284793
value: 1.8106416E-16

291922
type: SpeciesReference
stoichiometry: 1.0
species: 561915

291910
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291898
type: SpeciesReference
stoichiometry: 1.0
species: 564835

564835
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

570694
type: Reaction
kinetic law: 295622
product: 295610
reactant: 295598
reactant: 295585
fast: false
reversible: true

295622
type: KineticLaw
local parameters: 052390
local parameters: 052387
notes: k1*AMPAR_slash_A_B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx

052390
type: LocalParameter
units: 284709
value: 2.16E-15

052387
type: LocalParameter
units: 284793
value: 3.5998992E-16

295610
type: SpeciesReference
stoichiometry: 1.0
species: 562895

295598
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295585
type: SpeciesReference
stoichiometry: 1.0
species: 564735

569694
type: Reaction
kinetic law: 293201
product: 293189
reactant: 293177
reactant: 293165
fast: false
reversible: true

293201
type: KineticLaw
local parameters: 052228
local parameters: 052225
notes: k1*AMPAR_memb_slash_A845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx

052228
type: LocalParameter
units: 284709
value: 7.2E-16

052225
type: LocalParameter
units: 284793
value: 2.011824E-17

293189
type: SpeciesReference
stoichiometry: 1.0
species: 562195

293177
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293165
type: SpeciesReference
stoichiometry: 1.0
species: 565035

571874
type: Reaction
kinetic law: 298577
product: 298565
product: 298553
reactant: 298540
fast: false
reversible: false

298577
type: KineticLaw
local parameters: 052578
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

052578
type: LocalParameter
units: 284709
value: 2.5E-17

298565
type: SpeciesReference
stoichiometry: 1.0
species: 563755

298553
type: SpeciesReference
stoichiometry: 1.0
species: 560475

298540
type: SpeciesReference
stoichiometry: 1.0
species: 563795

568995
type: Reaction
kinetic law: 291115
product: 291103
product: 291091
reactant: 291078
fast: false
reversible: false

291115
type: KineticLaw
local parameters: 052089
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx

052089
type: LocalParameter
units: 284709
value: 3.06E-17

291103
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291091
type: SpeciesReference
stoichiometry: 1.0
species: 561335

291078
type: SpeciesReference
stoichiometry: 1.0
species: 561735

571454
type: Reaction
kinetic law: 297562
product: 297549
reactant: 297537
reactant: 297525
fast: false
reversible: true

297562
type: KineticLaw
local parameters: 052516
local parameters: 052513
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx

052516
type: LocalParameter
units: 284709
value: 2.16E-15

052513
type: LocalParameter
units: 284793
value: 3.999888E-17

297549
type: SpeciesReference
stoichiometry: 1.0
species: 563295

563295
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

297537
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297525
type: SpeciesReference
stoichiometry: 1.0
species: 565195

560715
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 560175

568255
type: Reaction
kinetic law: 289325
product: 289313
reactant: 289301
reactant: 289289
fast: false
reversible: true

289325
type: KineticLaw
local parameters: 051966
local parameters: 051964
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx

051966
type: LocalParameter
units: 284709
value: 2.0E-17

051964
type: LocalParameter
units: 284793
value: 2.77776E-19

289313
type: SpeciesReference
stoichiometry: 1.0
species: 560895

289301
type: SpeciesReference
stoichiometry: 1.0
species: 565595

289289
type: SpeciesReference
stoichiometry: 1.0
species: 565155

567455
type: Reaction
kinetic law: 287394
product: 287382
reactant: 287370
fast: false
reversible: true

287394
type: KineticLaw
local parameters: 051861
local parameters: 051859
notes: kf*Ca_control_cyt-kb*Ca

051861
type: LocalParameter
units: 284709
value: 9.0E-15

051859
type: LocalParameter
units: 284709
value: 9.0E-15

287382
type: SpeciesReference
stoichiometry: 1.0
species: 560215

287370
type: SpeciesReference
stoichiometry: 1.0
species: 565435

570754
type: Reaction
kinetic law: 295766
product: 295754
product: 295742
reactant: 295730
fast: false
reversible: false

295766
type: KineticLaw
local parameters: 052397
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx

052397
type: LocalParameter
units: 284709
value: 5.4E-16

295754
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295742
type: SpeciesReference
stoichiometry: 1.0
species: 564775

295730
type: SpeciesReference
stoichiometry: 1.0
species: 562915

571214
type: Reaction
kinetic law: 296974
product: 296962
reactant: 296950
reactant: 296937
fast: false
reversible: true

296974
type: KineticLaw
local parameters: 052477
local parameters: 052474
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx

052477
type: LocalParameter
units: 284709
value: 2.16E-15

052474
type: LocalParameter
units: 284793
value: 3.999888E-17

296962
type: SpeciesReference
stoichiometry: 1.0
species: 563175

296950
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296937
type: SpeciesReference
stoichiometry: 1.0
species: 564995

569095
type: Reaction
kinetic law: 291356
product: 291344
reactant: 291332
reactant: 291320
fast: false
reversible: true

291356
type: KineticLaw
local parameters: 052106
local parameters: 052103
notes: k1*AMPAR_slash_A845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx

052106
type: LocalParameter
units: 284709
value: 7.2E-16

052103
type: LocalParameter
units: 284793
value: 1.8106416E-16

291344
type: SpeciesReference
stoichiometry: 1.0
species: 561795

291332
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291320
type: SpeciesReference
stoichiometry: 1.0
species: 564695

571514
type: Reaction
kinetic law: 297706
product: 297694
product: 297682
reactant: 297670
fast: false
reversible: false

297706
type: KineticLaw
local parameters: 052523
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx

052523
type: LocalParameter
units: 284709
value: 5.4E-16

297694
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297682
type: SpeciesReference
stoichiometry: 1.0
species: 565255

297670
type: SpeciesReference
stoichiometry: 1.0
species: 563315

571814
type: Reaction
kinetic law: 298431
product: 298419
reactant: 298406
reactant: 298394
fast: false
reversible: true

298431
type: KineticLaw
local parameters: 052571
local parameters: 052568
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

052571
type: LocalParameter
units: 284709
value: 1.0E-16

052568
type: LocalParameter
units: 284793
value: 6.2502E-17

298419
type: SpeciesReference
stoichiometry: 1.0
species: 563775

298406
type: SpeciesReference
stoichiometry: 1.0
species: 563755

298394
type: SpeciesReference
stoichiometry: 1.0
species: 560555

568635
type: Reaction
kinetic law: 290243
product: 290231
product: 290219
reactant: 290207
fast: false
reversible: false

290243
type: KineticLaw
local parameters: 052028
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

052028
type: LocalParameter
units: 284709
value: 2.25E-16

290231
type: SpeciesReference
stoichiometry: 1.0
species: 561455

290219
type: SpeciesReference
stoichiometry: 1.0
species: 560255

290207
type: SpeciesReference
stoichiometry: 1.0
species: 561475

564475
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

566855
type: Reaction
kinetic law: 286072
product: 286060
reactant: 286048
reactant: 286036
fast: false
reversible: true

286072
type: KineticLaw
local parameters: 051771
local parameters: 051769
notes: kf*CaM_slash_CaM_minus_Ca4*PP2B_slash_CaNAB_minus_Ca4-kb*PP2B_slash_CaM_Ca_n_minus_CaNAB

051771
type: LocalParameter
units: 284709
value: 9.0E-17

051769
type: LocalParameter
units: 284793
value: 5.399946E-14

286060
type: SpeciesReference
stoichiometry: 1.0
species: 561675

286048
type: SpeciesReference
stoichiometry: 1.0
species: 561615

286036
type: SpeciesReference
stoichiometry: 1.0
species: 561255

562335
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

568315
type: Reaction
kinetic law: 289471
product: 289459
product: 289446
reactant: 289434
fast: false
reversible: false

289471
type: KineticLaw
local parameters: 051972
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx

051972
type: LocalParameter
units: 284709
value: 5.0E-18

289459
type: SpeciesReference
stoichiometry: 1.0
species: 565595

289446
type: SpeciesReference
stoichiometry: 1.0
species: 565075

289434
type: SpeciesReference
stoichiometry: 1.0
species: 560915

560915
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 560175

569155
type: Reaction
kinetic law: 291597
product: 291585
product: 291573
reactant: 291560
fast: false
reversible: false

291597
type: KineticLaw
local parameters: 052119
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx

052119
type: LocalParameter
units: 284709
value: 1.8E-16

291585
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291573
type: SpeciesReference
stoichiometry: 1.0
species: 564875

291560
type: SpeciesReference
stoichiometry: 1.0
species: 561835

570174
type: Reaction
kinetic law: 294366
product: 294354
reactant: 294342
reactant: 294330
fast: false
reversible: true

294366
type: KineticLaw
local parameters: 052305
local parameters: 052302
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx

052305
type: LocalParameter
units: 284709
value: 7.2E-16

052302
type: LocalParameter
units: 284793
value: 2.011824E-17

294354
type: SpeciesReference
stoichiometry: 1.0
species: 562435

294342
type: SpeciesReference
stoichiometry: 1.0
species: 561675

294330
type: SpeciesReference
stoichiometry: 1.0
species: 565195

562755
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

571334
type: Reaction
kinetic law: 297263
product: 297251
reactant: 297239
reactant: 297227
fast: false
reversible: true

297263
type: KineticLaw
local parameters: 052497
local parameters: 052494
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx

052497
type: LocalParameter
units: 284709
value: 2.16E-15

052494
type: LocalParameter
units: 284793
value: 3.999888E-17

297251
type: SpeciesReference
stoichiometry: 1.0
species: 563235

297239
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297227
type: SpeciesReference
stoichiometry: 1.0
species: 565115

561295
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

568155
type: Reaction
kinetic law: 289082
product: 289070
product: 289058
reactant: 289046
fast: false
reversible: false

289082
type: KineticLaw
local parameters: 051952
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx

051952
type: LocalParameter
units: 284709
value: 5.0E-18

289070
type: SpeciesReference
stoichiometry: 1.0
species: 565595

289058
type: SpeciesReference
stoichiometry: 1.0
species: 565075

289046
type: SpeciesReference
stoichiometry: 1.0
species: 560835

570594
type: Reaction
kinetic law: 295379
product: 295367
product: 295355
reactant: 295343
fast: false
reversible: false

295379
type: KineticLaw
local parameters: 052372
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx

052372
type: LocalParameter
units: 284709
value: 5.4E-16

295367
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295355
type: SpeciesReference
stoichiometry: 1.0
species: 564955

295343
type: SpeciesReference
stoichiometry: 1.0
species: 562835

570954
type: Reaction
kinetic law: 296249
product: 296237
product: 296225
reactant: 296213
fast: false
reversible: false

296249
type: KineticLaw
local parameters: 052427
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx

052427
type: LocalParameter
units: 284709
value: 5.4E-16

296237
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296225
type: SpeciesReference
stoichiometry: 1.0
species: 564795

296213
type: SpeciesReference
stoichiometry: 1.0
species: 563015

572514
type: Reaction
kinetic law: 300124
product: 300112
product: 300100
reactant: 300088
fast: false
reversible: false

300124
type: KineticLaw
local parameters: 052684
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx

052684
type: LocalParameter
units: 284709
value: 1.7E-18

300112
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300100
type: SpeciesReference
stoichiometry: 1.0
species: 565115

300088
type: SpeciesReference
stoichiometry: 1.0
species: 564115

572934
type: Reaction
kinetic law: 301140
product: 301128
reactant: 301116
reactant: 301104
fast: false
reversible: true

301140
type: KineticLaw
local parameters: 052755
local parameters: 052753
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx

052755
type: LocalParameter
units: 284709
value: 1.4E-17

052753
type: LocalParameter
units: 284793
value: 8.7498E-18

301128
type: SpeciesReference
stoichiometry: 1.0
species: 564335

301116
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301104
type: SpeciesReference
stoichiometry: 1.0
species: 565255

570634
type: Reaction
kinetic law: 295476
product: 295464
product: 295452
reactant: 295440
fast: false
reversible: false

295476
type: KineticLaw
local parameters: 052378
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx

052378
type: LocalParameter
units: 284709
value: 5.4E-16

295464
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295452
type: SpeciesReference
stoichiometry: 1.0
species: 564835

295440
type: SpeciesReference
stoichiometry: 1.0
species: 562855

571394
type: Reaction
kinetic law: 297416
product: 297404
product: 297391
reactant: 297379
fast: false
reversible: false

297416
type: KineticLaw
local parameters: 052504
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx

052504
type: LocalParameter
units: 284709
value: 5.4E-16

297404
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297391
type: SpeciesReference
stoichiometry: 1.0
species: 565175

297379
type: SpeciesReference
stoichiometry: 1.0
species: 563255

563255
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

572274
type: Reaction
kinetic law: 299543
product: 299531
product: 299519
reactant: 299507
fast: false
reversible: false

299543
type: KineticLaw
local parameters: 052644
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx

052644
type: LocalParameter
units: 284709
value: 1.7E-18

299531
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299519
type: SpeciesReference
stoichiometry: 1.0
species: 564995

299507
type: SpeciesReference
stoichiometry: 1.0
species: 563995

563995
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

568515
type: Reaction
kinetic law: 289953
product: 289941
product: 289929
reactant: 289917
fast: false
reversible: false

289953
type: KineticLaw
local parameters: 052009
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx

052009
type: LocalParameter
units: 284709
value: 1.8E-16

289941
type: SpeciesReference
stoichiometry: 1.0
species: 561355

289929
type: SpeciesReference
stoichiometry: 1.0
species: 561335

289917
type: SpeciesReference
stoichiometry: 1.0
species: 561395

573034
type: Reaction
kinetic law: 301381
product: 301369
product: 301357
reactant: 301344
fast: false
reversible: false

301381
type: KineticLaw
local parameters: 052772
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx

052772
type: LocalParameter
units: 284709
value: 3.5E-18

301369
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301357
type: SpeciesReference
stoichiometry: 1.0
species: 565115

301344
type: SpeciesReference
stoichiometry: 1.0
species: 564375

572694
type: Reaction
kinetic law: 300560
product: 300548
reactant: 300536
reactant: 300524
fast: false
reversible: true

300560
type: KineticLaw
local parameters: 052715
local parameters: 052712
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx

052715
type: LocalParameter
units: 284709
value: 6.8E-18

052712
type: LocalParameter
units: 284793
value: 8.7498E-18

300548
type: SpeciesReference
stoichiometry: 1.0
species: 564215

300536
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300524
type: SpeciesReference
stoichiometry: 1.0
species: 565195

573294
type: Reaction
kinetic law: 302018
product: 302006
reactant: 301994
reactant: 301982
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

302018
type: KineticLaw
local parameters: 052830
local parameters: 052827
notes: k1*CaM_slash_neurogranin*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx

052830
type: LocalParameter
units: 284709
value: 2.106E-16

052827
type: LocalParameter
units: 284793
value: 9.180054E-18

302006
type: SpeciesReference
stoichiometry: 1.0
species: 564535

301994
type: SpeciesReference
stoichiometry: 1.0
species: 564515

301982
type: SpeciesReference
stoichiometry: 1.0
species: 561055

566735
type: Reaction
kinetic law: 285791
product: 285779
reactant: 285767
reactant: 285755
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true

285791
type: KineticLaw
local parameters: 051753
local parameters: 051751
notes: kf*CaM_slash_CaM_minus_Ca3*Ca-kb*CaM_slash_CaM_minus_Ca4

051753
type: LocalParameter
units: 284709
value: 9.0E-16

051751
type: LocalParameter
units: 284793
value: 4.1849946E-17

285779
type: SpeciesReference
stoichiometry: 1.0
species: 561255

285767
type: SpeciesReference
stoichiometry: 1.0
species: 560215

285755
type: SpeciesReference
stoichiometry: 1.0
species: 561175

569035
type: Reaction
kinetic law: 291211
product: 291199
product: 291187
reactant: 291175
fast: false
reversible: false

291211
type: KineticLaw
local parameters: 052095
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx

052095
type: LocalParameter
units: 284709
value: 3.06E-17

291199
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291187
type: SpeciesReference
stoichiometry: 1.0
species: 563675

291175
type: SpeciesReference
stoichiometry: 1.0
species: 561755

567595
type: Reaction
kinetic law: 287729
product: 287717
product: 287705
reactant: 287693
fast: false
reversible: false

287729
type: KineticLaw
local parameters: 051879
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx

051879
type: LocalParameter
units: 284709
value: 5.4E-16

287717
type: SpeciesReference
stoichiometry: 1.0
species: 565495

287705
type: SpeciesReference
stoichiometry: 1.0
species: 560295

287693
type: SpeciesReference
stoichiometry: 1.0
species: 560375

570537
type: Reaction
kinetic law: 295234
product: 295222
reactant: 295210
reactant: 295198
fast: false
reversible: true

295234
type: KineticLaw
local parameters: 052365
local parameters: 052362
notes: k1*AMPAR_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx

052365
type: LocalParameter
units: 284709
value: 2.16E-15

052362
type: LocalParameter
units: 284793
value: 3.5998992E-16

295222
type: SpeciesReference
stoichiometry: 1.0
species: 562815

295210
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295198
type: SpeciesReference
stoichiometry: 1.0
species: 564655

570214
type: Reaction
kinetic law: 294463
product: 294451
reactant: 294439
reactant: 294427
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true

294463
type: KineticLaw
local parameters: 052312
local parameters: 052309
notes: k1*CaM_slash_neurogranin_star__PSD*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx

052312
type: LocalParameter
units: 284709
value: 2.403E-16

052309
type: LocalParameter
units: 284793
value: 3.336012E-18

294451
type: SpeciesReference
stoichiometry: 1.0
species: 562455

294439
type: SpeciesReference
stoichiometry: 1.0
species: 561675

294427
type: SpeciesReference
stoichiometry: 1.0
species: 561135

562215
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

569994
type: Reaction
kinetic law: 293929
product: 293917
product: 293905
reactant: 293893
fast: false
reversible: false

293929
type: KineticLaw
local parameters: 052271
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx

052271
type: LocalParameter
units: 284709
value: 1.8E-16

293917
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293905
type: SpeciesReference
stoichiometry: 1.0
species: 565000

293893
type: SpeciesReference
stoichiometry: 1.0
species: 562335

570054
type: Reaction
kinetic law: 294074
product: 294062
reactant: 294050
reactant: 294038
fast: false
reversible: true

294074
type: KineticLaw
local parameters: 052284
local parameters: 052281
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx

052284
type: LocalParameter
units: 284709
value: 7.2E-16

052281
type: LocalParameter
units: 284793
value: 2.011824E-17

294062
type: SpeciesReference
stoichiometry: 1.0
species: 562375

294050
type: SpeciesReference
stoichiometry: 1.0
species: 561675

294038
type: SpeciesReference
stoichiometry: 1.0
species: 565255

565855
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

569215
type: Reaction
kinetic law: 291741
product: 291729
reactant: 291717
reactant: 291705
fast: false
reversible: true

291741
type: KineticLaw
local parameters: 052130
local parameters: 052127
notes: k1*AMPAR_slash_A_B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx

052130
type: LocalParameter
units: 284709
value: 7.2E-16

052127
type: LocalParameter
units: 284793
value: 1.8106416E-16

291729
type: SpeciesReference
stoichiometry: 1.0
species: 561875

291717
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291705
type: SpeciesReference
stoichiometry: 1.0
species: 564735

565455
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 560175

569674
type: Reaction
kinetic law: 293153
product: 293141
product: 293128
reactant: 293116
fast: false
reversible: false

293153
type: KineticLaw
local parameters: 052222
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx

052222
type: LocalParameter
units: 284709
value: 1.8E-16

293141
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293128
type: SpeciesReference
stoichiometry: 1.0
species: 564975

293116
type: SpeciesReference
stoichiometry: 1.0
species: 562175

573174
type: Reaction
kinetic law: 301719
product: 301707
reactant: 301695
reactant: 301683
fast: false
reversible: true

301719
type: KineticLaw
local parameters: 052803
local parameters: 052800
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx

052803
type: LocalParameter
units: 284709
value: 1.4E-17

052800
type: LocalParameter
units: 284793
value: 8.7498E-18

301707
type: SpeciesReference
stoichiometry: 1.0
species: 564455

301695
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301683
type: SpeciesReference
stoichiometry: 1.0
species: 565075

567475
type: Reaction
kinetic law: 287430
product: 287418
reactant: 287406
fast: false
reversible: true

287430
type: KineticLaw
local parameters: 051864
local parameters: 051862
notes: kf*Ca_control_PSD-kb*Ca_minus_PSD

051864
type: LocalParameter
units: 284709
value: 1.0E-15

051862
type: LocalParameter
units: 284709
value: 1.0E-15

287418
type: SpeciesReference
stoichiometry: 1.0
species: 563655

287406
type: SpeciesReference
stoichiometry: 1.0
species: 565455

571534
type: Reaction
kinetic law: 297755
product: 297743
reactant: 297730
reactant: 297718
fast: false
reversible: true

297755
type: KineticLaw
local parameters: 052528
local parameters: 052525
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx

052528
type: LocalParameter
units: 284709
value: 2.16E-15

052525
type: LocalParameter
units: 284793
value: 3.999888E-17

297743
type: SpeciesReference
stoichiometry: 1.0
species: 563335

297730
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297718
type: SpeciesReference
stoichiometry: 1.0
species: 565015

571035
type: Reaction
kinetic law: 296538
product: 296526
product: 296514
reactant: 296502
fast: false
reversible: false

296538
type: KineticLaw
local parameters: 052445
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx

052445
type: LocalParameter
units: 284709
value: 5.4E-16

296526
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296514
type: SpeciesReference
stoichiometry: 1.0
species: 565135

296502
type: SpeciesReference
stoichiometry: 1.0
species: 563075

571954
type: Reaction
kinetic law: 298770
product: 298758
product: 298746
reactant: 298734
fast: false
reversible: false

298770
type: KineticLaw
local parameters: 052592
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

052592
type: LocalParameter
units: 284709
value: 2.5E-17

298758
type: SpeciesReference
stoichiometry: 1.0
species: 563755

298746
type: SpeciesReference
stoichiometry: 1.0
species: 560435

298734
type: SpeciesReference
stoichiometry: 1.0
species: 563835

568655
type: Reaction
kinetic law: 290291
product: 290279
reactant: 290267
reactant: 290255
fast: false
reversible: true

290291
type: KineticLaw
local parameters: 052033
local parameters: 052031
notes: k1*CaMKII_slash_CaMKII_minus_thr286*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

052033
type: LocalParameter
units: 284709
value: 9.0E-16

052031
type: LocalParameter
units: 284793
value: 2.2062942E-16

290279
type: SpeciesReference
stoichiometry: 1.0
species: 561495

290267
type: SpeciesReference
stoichiometry: 1.0
species: 561455

290255
type: SpeciesReference
stoichiometry: 1.0
species: 560315

568615
type: Reaction
kinetic law: 290195
product: 290183
reactant: 290170
reactant: 290158
fast: false
reversible: true

290195
type: KineticLaw
local parameters: 052025
local parameters: 052023
notes: k1*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

052025
type: LocalParameter
units: 284709
value: 9.0E-16

052023
type: LocalParameter
units: 284793
value: 2.2062942E-16

290183
type: SpeciesReference
stoichiometry: 1.0
species: 561475

290170
type: SpeciesReference
stoichiometry: 1.0
species: 561455

290158
type: SpeciesReference
stoichiometry: 1.0
species: 560275

566595
type: Reaction
kinetic law: 285474
product: 285462
reactant: 285450
reactant: 285438
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true

285474
type: KineticLaw
local parameters: 051732
local parameters: 051730
notes: kf*CaM_slash_neurogranin*CaM_slash_CaM-kb*CaM_slash_neurogranin_minus_CaM

051732
type: LocalParameter
units: 284709
value: 9.0E-17

051730
type: LocalParameter
units: 284793
value: 2.7000216E-17

285462
type: SpeciesReference
stoichiometry: 1.0
species: 561015

561015
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

285450
type: SpeciesReference
stoichiometry: 1.0
species: 560995

285438
type: SpeciesReference
stoichiometry: 1.0
species: 561055

569874
type: Reaction
kinetic law: 293640
product: 293627
product: 293614
reactant: 293602
fast: false
reversible: false

293640
type: KineticLaw
local parameters: 052253
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx

052253
type: LocalParameter
units: 284709
value: 1.8E-16

293627
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293614
type: SpeciesReference
stoichiometry: 1.0
species: 564995

293602
type: SpeciesReference
stoichiometry: 1.0
species: 562275

567895
type: Reaction
kinetic law: 288454
product: 288442
reactant: 288430
reactant: 288417
fast: false
reversible: true

288454
type: KineticLaw
local parameters: 051919
local parameters: 051917
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx

051919
type: LocalParameter
units: 284709
value: 2.0E-17

051917
type: LocalParameter
units: 284793
value: 2.77776E-19

288442
type: SpeciesReference
stoichiometry: 1.0
species: 560715

288430
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288417
type: SpeciesReference
stoichiometry: 1.0
species: 565135

569175
type: Reaction
kinetic law: 291645
product: 291633
reactant: 291621
reactant: 291609
fast: false
reversible: true

291645
type: KineticLaw
local parameters: 052124
local parameters: 052121
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx

052124
type: LocalParameter
units: 284709
value: 7.2E-16

052121
type: LocalParameter
units: 284793
value: 1.8106416E-16

291633
type: SpeciesReference
stoichiometry: 1.0
species: 561855

291621
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291609
type: SpeciesReference
stoichiometry: 1.0
species: 564935

566355
type: Reaction
kinetic law: 284901
product: 284889
reactant: 284877
reactant: 284865
notes: This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
fast: false
reversible: true

284901
type: KineticLaw
local parameters: 051696
local parameters: 051693
notes: kf*CaM_slash_CaM_minus_Ca4*CaMKII_slash_CaMKII-kb*CaMKII_slash_CaMKII_minus_CaM

051696
type: LocalParameter
units: 284709
value: 4.5E-16

051693
type: LocalParameter
units: 284793
value: 4.4999712E-15

284889
type: SpeciesReference
stoichiometry: 1.0
species: 560255

284877
type: SpeciesReference
stoichiometry: 1.0
species: 560235

284865
type: SpeciesReference
stoichiometry: 1.0
species: 561255

568135
type: Reaction
kinetic law: 289034
product: 289022
reactant: 289010
reactant: 288998
fast: false
reversible: true

289034
type: KineticLaw
local parameters: 051951
local parameters: 051948
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx

051951
type: LocalParameter
units: 284709
value: 2.0E-17

051948
type: LocalParameter
units: 284793
value: 2.77776E-19

289022
type: SpeciesReference
stoichiometry: 1.0
species: 560835

289010
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288998
type: SpeciesReference
stoichiometry: 1.0
species: 565115

570654
type: Reaction
kinetic law: 295524
product: 295512
reactant: 295500
reactant: 295488
fast: false
reversible: true

295524
type: KineticLaw
local parameters: 052384
local parameters: 052381
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx

052384
type: LocalParameter
units: 284709
value: 2.16E-15

052381
type: LocalParameter
units: 284793
value: 3.5998992E-16

295512
type: SpeciesReference
stoichiometry: 1.0
species: 562875

295500
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295488
type: SpeciesReference
stoichiometry: 1.0
species: 564915

572914
type: Reaction
kinetic law: 301092
product: 301080
product: 301068
reactant: 301056
fast: false
reversible: false

301092
type: KineticLaw
local parameters: 052752
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx

052752
type: LocalParameter
units: 284709
value: 3.5E-18

301080
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301068
type: SpeciesReference
stoichiometry: 1.0
species: 564975

301056
type: SpeciesReference
stoichiometry: 1.0
species: 564315

564315
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

571414
type: Reaction
kinetic law: 297464
product: 297452
reactant: 297440
reactant: 297428
fast: false
reversible: true

297464
type: KineticLaw
local parameters: 052509
local parameters: 052506
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx

052509
type: LocalParameter
units: 284709
value: 2.16E-15

052506
type: LocalParameter
units: 284793
value: 3.999888E-17

297452
type: SpeciesReference
stoichiometry: 1.0
species: 563275

297440
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297428
type: SpeciesReference
stoichiometry: 1.0
species: 565000

569394
type: Reaction
kinetic law: 292375
product: 292362
product: 292349
reactant: 292336
fast: false
reversible: false

292375
type: KineticLaw
local parameters: 052170
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx

052170
type: LocalParameter
units: 284709
value: 1.8E-16

292362
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292349
type: SpeciesReference
stoichiometry: 1.0
species: 564835

292336
type: SpeciesReference
stoichiometry: 1.0
species: 561995

571834
type: Reaction
kinetic law: 298480
product: 298468
product: 298456
reactant: 298443
fast: false
reversible: false

298480
type: KineticLaw
local parameters: 052572
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

052572
type: LocalParameter
units: 284709
value: 2.5E-17

298468
type: SpeciesReference
stoichiometry: 1.0
species: 563755

298456
type: SpeciesReference
stoichiometry: 1.0
species: 560535

298443
type: SpeciesReference
stoichiometry: 1.0
species: 563775

568535
type: Reaction
kinetic law: 290001
product: 289989
reactant: 289977
reactant: 289965
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true

290001
type: KineticLaw
local parameters: 052014
local parameters: 052011
notes: k1*PP1_PSD_slash_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx

052014
type: LocalParameter
units: 284709
value: 7.50006E-16

052011
type: LocalParameter
units: 284793
value: 6.4584E-18

289989
type: SpeciesReference
stoichiometry: 1.0
species: 561415

289977
type: SpeciesReference
stoichiometry: 1.0
species: 561355

289965
type: SpeciesReference
stoichiometry: 1.0
species: 563695

568955
type: Reaction
kinetic law: 291018
product: 291005
product: 290993
reactant: 290980
fast: false
reversible: false

291018
type: KineticLaw
local parameters: 052083
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx

052083
type: LocalParameter
units: 284709
value: 3.06E-17

291005
type: SpeciesReference
stoichiometry: 1.0
species: 561675

290993
type: SpeciesReference
stoichiometry: 1.0
species: 561275

290980
type: SpeciesReference
stoichiometry: 1.0
species: 561715

566475
type: Reaction
kinetic law: 285180
product: 285168
reactant: 285156
fast: false
reversible: true

285180
type: KineticLaw
local parameters: 051714
local parameters: 051712
notes: kf*CaMKII_slash_basal_CaMKII_PSD_control-kb*CaMKII_slash_basal_CaMKII_PSD

051714
type: LocalParameter
units: 284709
value: 1.0E-17

051712
type: LocalParameter
units: 284709
value: 1.0E-17

285168
type: SpeciesReference
stoichiometry: 1.0
species: 560615

560615
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 560175

285156
type: SpeciesReference
stoichiometry: 1.0
species: 565335

565335
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 560175

572674
type: Reaction
kinetic law: 300511
product: 300499
product: 300487
reactant: 300475
fast: false
reversible: false

300511
type: KineticLaw
local parameters: 052710
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx

052710
type: LocalParameter
units: 284709
value: 1.7E-18

300499
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300487
type: SpeciesReference
stoichiometry: 1.0
species: 565075

300475
type: SpeciesReference
stoichiometry: 1.0
species: 564195

567355
type: Reaction
kinetic law: 287200
product: 287188
reactant: 287175
reactant: 287163
fast: false
reversible: true

287200
type: KineticLaw
local parameters: 051846
local parameters: 051844
notes: kf*AMPAR_slash_A831_star_845_star__B845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A831_star_845_star__B845_star_

051846
type: LocalParameter
units: 284709
value: 8.0E-20

051844
type: LocalParameter
units: 284793
value: 1.08E-19

287188
type: SpeciesReference
stoichiometry: 1.0
species: 565215

287175
type: SpeciesReference
stoichiometry: 1.0
species: 565295

287163
type: SpeciesReference
stoichiometry: 1.0
species: 564775

568215
type: Reaction
kinetic law: 289229
product: 289217
reactant: 289205
reactant: 289192
fast: false
reversible: true

289229
type: KineticLaw
local parameters: 051961
local parameters: 051959
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx

051961
type: LocalParameter
units: 284709
value: 2.0E-17

051959
type: LocalParameter
units: 284793
value: 2.77776E-19

289217
type: SpeciesReference
stoichiometry: 1.0
species: 560875

289205
type: SpeciesReference
stoichiometry: 1.0
species: 565595

289192
type: SpeciesReference
stoichiometry: 1.0
species: 565215

569634
type: Reaction
kinetic law: 293056
product: 293044
product: 293032
reactant: 293020
fast: false
reversible: false

293056
type: KineticLaw
local parameters: 052216
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx

052216
type: LocalParameter
units: 284709
value: 1.8E-16

293044
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293032
type: SpeciesReference
stoichiometry: 1.0
species: 565035

293020
type: SpeciesReference
stoichiometry: 1.0
species: 562155

567655
type: Reaction
kinetic law: 287874
product: 287861
reactant: 287849
reactant: 287837
fast: false
reversible: true

287874
type: KineticLaw
local parameters: 051888
local parameters: 051886
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*CaMKII_slash_tot_minus_auto_minus_PSD-k2*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx

051888
type: LocalParameter
units: 284709
value: 2.4E-16

051886
type: LocalParameter
units: 284793
value: 2.4E-18

287861
type: SpeciesReference
stoichiometry: 1.0
species: 560575

287849
type: SpeciesReference
stoichiometry: 1.0
species: 565555

287837
type: SpeciesReference
stoichiometry: 1.0
species: 560515

569055
type: Reaction
kinetic law: 291260
product: 291248
reactant: 291236
reactant: 291223
fast: false
reversible: true

291260
type: KineticLaw
local parameters: 052100
local parameters: 052097
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx

052100
type: LocalParameter
units: 284709
value: 1.224E-16

052097
type: LocalParameter
units: 284793
value: 3.420036E-18

291248
type: SpeciesReference
stoichiometry: 1.0
species: 561775

291236
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291223
type: SpeciesReference
stoichiometry: 1.0
species: 563715

563975
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

572194
type: Reaction
kinetic law: 299351
product: 299339
product: 299327
reactant: 299315
fast: false
reversible: false

299351
type: KineticLaw
local parameters: 052631
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx

052631
type: LocalParameter
units: 284709
value: 1.7E-18

299339
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299327
type: SpeciesReference
stoichiometry: 1.0
species: 565055

299315
type: SpeciesReference
stoichiometry: 1.0
species: 563955

570854
type: Reaction
kinetic law: 296009
product: 295997
reactant: 295985
reactant: 295973
fast: false
reversible: true

296009
type: KineticLaw
local parameters: 052414
local parameters: 052411
notes: k1*AMPAR_slash_A845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx

052414
type: LocalParameter
units: 284709
value: 2.16E-15

052411
type: LocalParameter
units: 284793
value: 3.5998992E-16

295997
type: SpeciesReference
stoichiometry: 1.0
species: 562975

295985
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295973
type: SpeciesReference
stoichiometry: 1.0
species: 564695

568015
type: Reaction
kinetic law: 288743
product: 288731
reactant: 288719
reactant: 288707
fast: false
reversible: true

288743
type: KineticLaw
local parameters: 051934
local parameters: 051932
notes: k1*AMPAR_memb_slash_A_B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx

051934
type: LocalParameter
units: 284709
value: 2.0E-17

051932
type: LocalParameter
units: 284793
value: 2.77776E-19

288731
type: SpeciesReference
stoichiometry: 1.0
species: 560775

560775
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 560175

288719
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288707
type: SpeciesReference
stoichiometry: 1.0
species: 564975

565875
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

566495
type: Reaction
kinetic law: 285229
product: 285216
product: 285204
reactant: 285192
fast: false
reversible: true

285229
type: KineticLaw
local parameters: 051717
local parameters: 051715
notes: kf*CaMKII_slash_CaMKII_minus_CaM_minus_PSD-kb*CaM_slash_CaM_minus_Ca4_minus_PSD*CaMKII_slash_CaMKII_minus_PSD

051717
type: LocalParameter
units: 284793
value: 0.0

051715
type: LocalParameter
units: 284709
value: 5.0E-17

285216
type: SpeciesReference
stoichiometry: 1.0
species: 560475

285204
type: SpeciesReference
stoichiometry: 1.0
species: 561195

285192
type: SpeciesReference
stoichiometry: 1.0
species: 560535

569754
type: Reaction
kinetic law: 293346
product: 293334
product: 293322
reactant: 293310
fast: false
reversible: false

293346
type: KineticLaw
local parameters: 052235
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx

052235
type: LocalParameter
units: 284709
value: 1.8E-16

293334
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293322
type: SpeciesReference
stoichiometry: 1.0
species: 565155

293310
type: SpeciesReference
stoichiometry: 1.0
species: 562215

567415
type: Reaction
kinetic law: 287321
product: 287309
reactant: 287297
fast: false
reversible: true

287321
type: KineticLaw
local parameters: 051855
local parameters: 051853
notes: kf*AMPAR_memb_slash_GluR23_M-kb*AMPAR_slash_GluR23_I

051855
type: LocalParameter
units: 284709
value: 1.26E-19

051853
type: LocalParameter
units: 284709
value: 3.5E-21

287309
type: SpeciesReference
stoichiometry: 1.0
species: 564635

564635
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0925925925925926
initial amount: NaN
in compartment: 560155

287297
type: SpeciesReference
stoichiometry: 1.0
species: 565275

565275
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.5
initial amount: NaN
in compartment: 560175

567175
type: Reaction
kinetic law: 286814
product: 286801
product: 286789
reactant: 286777
fast: false
reversible: true

286814
type: KineticLaw
local parameters: 051819
local parameters: 051817
notes: kf*AMPAR_memb_slash_A_B831_star_-kb*AMPAR_slash_A_B831_star_*AMPAR_memb_slash_Anchor

051819
type: LocalParameter
units: 284793
value: 0.0

051817
type: LocalParameter
units: 284709
value: 8.0E-21

286801
type: SpeciesReference
stoichiometry: 1.0
species: 565295

286789
type: SpeciesReference
stoichiometry: 1.0
species: 564875

286777
type: SpeciesReference
stoichiometry: 1.0
species: 565000

569275
type: Reaction
kinetic law: 291983
product: 291971
product: 291959
reactant: 291947
fast: false
reversible: false

291983
type: KineticLaw
local parameters: 052144
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx

052144
type: LocalParameter
units: 284709
value: 1.8E-16

291971
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291959
type: SpeciesReference
stoichiometry: 1.0
species: 564875

291947
type: SpeciesReference
stoichiometry: 1.0
species: 561915

570034
type: Reaction
kinetic law: 294026
product: 294014
product: 294002
reactant: 293990
fast: false
reversible: false

294026
type: KineticLaw
local parameters: 052278
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx

052278
type: LocalParameter
units: 284709
value: 1.8E-16

294014
type: SpeciesReference
stoichiometry: 1.0
species: 561675

294002
type: SpeciesReference
stoichiometry: 1.0
species: 565000

293990
type: SpeciesReference
stoichiometry: 1.0
species: 562355

570454
type: Reaction
kinetic law: 295042
product: 295030
reactant: 295018
reactant: 295006
fast: false
reversible: true

295042
type: KineticLaw
local parameters: 052353
local parameters: 052350
notes: k1*AMPAR_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx

052353
type: LocalParameter
units: 284709
value: 2.16E-15

052350
type: LocalParameter
units: 284793
value: 3.5998992E-16

295030
type: SpeciesReference
stoichiometry: 1.0
species: 562775

562775
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

295018
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295006
type: SpeciesReference
stoichiometry: 1.0
species: 564875

562715
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

573194
type: Reaction
kinetic law: 301767
product: 301755
product: 301743
reactant: 301731
fast: false
reversible: false

301767
type: KineticLaw
local parameters: 052806
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx

052806
type: LocalParameter
units: 284709
value: 3.5E-18

301755
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301743
type: SpeciesReference
stoichiometry: 1.0
species: 565055

301731
type: SpeciesReference
stoichiometry: 1.0
species: 564455

572394
type: Reaction
kinetic law: 299835
product: 299823
product: 299811
reactant: 299799
fast: false
reversible: false

299835
type: KineticLaw
local parameters: 052662
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx

052662
type: LocalParameter
units: 284709
value: 3.5E-18

299823
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299811
type: SpeciesReference
stoichiometry: 1.0
species: 565035

299799
type: SpeciesReference
stoichiometry: 1.0
species: 564055

569574
type: Reaction
kinetic law: 292910
product: 292897
reactant: 292884
reactant: 292872
fast: false
reversible: true

292910
type: KineticLaw
local parameters: 052209
local parameters: 052206
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx

052209
type: LocalParameter
units: 284709
value: 7.2E-16

052206
type: LocalParameter
units: 284793
value: 2.011824E-17

292897
type: SpeciesReference
stoichiometry: 1.0
species: 562135

292884
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292872
type: SpeciesReference
stoichiometry: 1.0
species: 565135

567535
type: Reaction
kinetic law: 287583
product: 287569
reactant: 287556
reactant: 287543
fast: false
reversible: true

287583
type: KineticLaw
local parameters: 051873
local parameters: 051870
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx

051873
type: LocalParameter
units: 284709
value: 1.8E-16

051870
type: LocalParameter
units: 284793
value: 1.9805958E-18

287569
type: SpeciesReference
stoichiometry: 1.0
species: 560355

560355
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.44537037037037E-8
initial amount: NaN
in compartment: 560155

287556
type: SpeciesReference
stoichiometry: 1.0
species: 565475

287543
type: SpeciesReference
stoichiometry: 1.0
species: 560255

568415
type: Reaction
kinetic law: 289712
product: 289700
reactant: 289688
reactant: 289676
fast: false
reversible: true

289712
type: KineticLaw
local parameters: 051992
local parameters: 051990
notes: k1*CaMKII_slash_CaMKII_minus_CaM_minus_PSD*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD-k2*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx

051992
type: LocalParameter
units: 284709
value: 2.0E-17

051990
type: LocalParameter
units: 284793
value: 3.07998E-19

289700
type: SpeciesReference
stoichiometry: 1.0
species: 560975

289688
type: SpeciesReference
stoichiometry: 1.0
species: 565615

289676
type: SpeciesReference
stoichiometry: 1.0
species: 560535

571094
type: Reaction
kinetic law: 296682
product: 296670
reactant: 296658
reactant: 296646
fast: false
reversible: true

296682
type: KineticLaw
local parameters: 052456
local parameters: 052453
notes: k1*AMPAR_memb_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx

052456
type: LocalParameter
units: 284709
value: 2.16E-15

052453
type: LocalParameter
units: 284793
value: 3.999888E-17

296670
type: SpeciesReference
stoichiometry: 1.0
species: 563115

563115
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

296658
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296646
type: SpeciesReference
stoichiometry: 1.0
species: 564975

565575
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 560175

570574
type: Reaction
kinetic law: 295331
product: 295319
reactant: 295307
reactant: 295295
fast: false
reversible: true

295331
type: KineticLaw
local parameters: 052371
local parameters: 052368
notes: k1*AMPAR_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx

052371
type: LocalParameter
units: 284709
value: 2.16E-15

052368
type: LocalParameter
units: 284793
value: 3.5998992E-16

295319
type: SpeciesReference
stoichiometry: 1.0
species: 562835

295307
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295295
type: SpeciesReference
stoichiometry: 1.0
species: 564675

565315
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 560155

573254
type: Reaction
kinetic law: 301916
product: 301903
reactant: 301890
reactant: 301877
fast: false
reversible: true

301916
type: KineticLaw
local parameters: 052821
local parameters: 052818
notes: k1*CaMKII_slash_CaMKII_minus_thr305_minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

052821
type: LocalParameter
units: 284709
value: 1.0E-16

052818
type: LocalParameter
units: 284793
value: 2.45142E-17

301903
type: SpeciesReference
stoichiometry: 1.0
species: 564495

564495
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

301890
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301877
type: SpeciesReference
stoichiometry: 1.0
species: 560435

567055
type: Reaction
kinetic law: 286536
product: 286523
reactant: 286511
notes: The rates for this are poorly constrained. In adipocytes (probably a different PDE) the dephosphorylation is complete within 15 min, but there are no intermediate time points so it could be much faster. Identity of phosphatase etc is still unknown.
fast: false
reversible: true

286536
type: KineticLaw
local parameters: 051801
local parameters: 051799
notes: kf*AC_slash_cAMP_minus_PDE_star_-kb*AC_slash_cAMP_minus_PDE

051801
type: LocalParameter
units: 284709
value: 0.0

051799
type: LocalParameter
units: 284709
value: 9.0E-19

286523
type: SpeciesReference
stoichiometry: 1.0
species: 563455

286511
type: SpeciesReference
stoichiometry: 1.0
species: 563495

569594
type: Reaction
kinetic law: 292959
product: 292947
product: 292935
reactant: 292923
fast: false
reversible: false

292959
type: KineticLaw
local parameters: 052210
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx

052210
type: LocalParameter
units: 284709
value: 1.8E-16

292947
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292935
type: SpeciesReference
stoichiometry: 1.0
species: 565095

292923
type: SpeciesReference
stoichiometry: 1.0
species: 562135

569894
type: Reaction
kinetic law: 293688
product: 293676
reactant: 293664
reactant: 293652
fast: false
reversible: true

293688
type: KineticLaw
local parameters: 052258
local parameters: 052255
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx

052258
type: LocalParameter
units: 284709
value: 7.2E-16

052255
type: LocalParameter
units: 284793
value: 2.011824E-17

293676
type: SpeciesReference
stoichiometry: 1.0
species: 562295

293664
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293652
type: SpeciesReference
stoichiometry: 1.0
species: 565235

565735
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

567555
type: Reaction
kinetic law: 287633
product: 287621
product: 287609
reactant: 287596
fast: false
reversible: false

287633
type: KineticLaw
local parameters: 051874
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx

051874
type: LocalParameter
units: 284709
value: 4.5E-17

287621
type: SpeciesReference
stoichiometry: 1.0
species: 565475

287609
type: SpeciesReference
stoichiometry: 1.0
species: 560275

287596
type: SpeciesReference
stoichiometry: 1.0
species: 560355

570334
type: Reaction
kinetic law: 294754
product: 294742
reactant: 294730
reactant: 294718
fast: false
reversible: true

294754
type: KineticLaw
local parameters: 052333
local parameters: 052330
notes: k1*PP1_PSD_slash_I1*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx

052333
type: LocalParameter
units: 284709
value: 3.24E-15

052330
type: LocalParameter
units: 284793
value: 5.99994E-17

294742
type: SpeciesReference
stoichiometry: 1.0
species: 562715

294730
type: SpeciesReference
stoichiometry: 1.0
species: 562655

294718
type: SpeciesReference
stoichiometry: 1.0
species: 563675

570734
type: Reaction
kinetic law: 295718
product: 295706
reactant: 295694
reactant: 295682
fast: false
reversible: true

295718
type: KineticLaw
local parameters: 052396
local parameters: 052393
notes: k1*AMPAR_slash_A831_star__B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx

052396
type: LocalParameter
units: 284709
value: 2.16E-15

052393
type: LocalParameter
units: 284793
value: 3.5998992E-16

295706
type: SpeciesReference
stoichiometry: 1.0
species: 562915

295694
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295682
type: SpeciesReference
stoichiometry: 1.0
species: 564955

566375
type: Reaction
kinetic law: 284949
product: 284937
reactant: 284925
reactant: 284913
notes: Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
fast: false
reversible: true

284949
type: KineticLaw
local parameters: 051699
local parameters: 051697
notes: kf*CaMKII_slash_CaMKII_minus_thr286*CaM_slash_CaM_minus_Ca4-kb*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM

051699
type: LocalParameter
units: 284709
value: 9.0E-18

051697
type: LocalParameter
units: 284793
value: 9.001692E-14

284937
type: SpeciesReference
stoichiometry: 1.0
species: 560275

284925
type: SpeciesReference
stoichiometry: 1.0
species: 561255

284913
type: SpeciesReference
stoichiometry: 1.0
species: 560315

568575
type: Reaction
kinetic law: 290098
product: 290085
reactant: 290073
reactant: 290061
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true

290098
type: KineticLaw
local parameters: 052020
local parameters: 052017
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx

052020
type: LocalParameter
units: 284709
value: 7.50006E-16

052017
type: LocalParameter
units: 284793
value: 6.4584E-18

290085
type: SpeciesReference
stoichiometry: 1.0
species: 561435

290073
type: SpeciesReference
stoichiometry: 1.0
species: 561355

290061
type: SpeciesReference
stoichiometry: 1.0
species: 563715

566675
type: Reaction
kinetic law: 285658
product: 285646
reactant: 285634
reactant: 285622
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true

285658
type: KineticLaw
local parameters: 051744
local parameters: 051742
notes: kf*CaM_slash_CaM_minus_Ca3_minus_PSD*Ca_minus_PSD-kb*CaM_slash_CaM_minus_Ca4_minus_PSD

051744
type: LocalParameter
units: 284709
value: 1.0E-16

051742
type: LocalParameter
units: 284793
value: 4.65012E-18

285646
type: SpeciesReference
stoichiometry: 1.0
species: 561195

285634
type: SpeciesReference
stoichiometry: 1.0
species: 563655

285622
type: SpeciesReference
stoichiometry: 1.0
species: 561215

569954
type: Reaction
kinetic law: 293832
product: 293820
product: 293808
reactant: 293796
fast: false
reversible: false

293832
type: KineticLaw
local parameters: 052265
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx

052265
type: LocalParameter
units: 284709
value: 1.8E-16

293820
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293808
type: SpeciesReference
stoichiometry: 1.0
species: 565115

293796
type: SpeciesReference
stoichiometry: 1.0
species: 562315

572154
type: Reaction
kinetic law: 299255
product: 299243
product: 299230
reactant: 299218
fast: false
reversible: false

299255
type: KineticLaw
local parameters: 052624
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx

052624
type: LocalParameter
units: 284709
value: 1.7E-18

299243
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299230
type: SpeciesReference
stoichiometry: 1.0
species: 565155

299218
type: SpeciesReference
stoichiometry: 1.0
species: 563935

565815
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

572574
type: Reaction
kinetic law: 300269
product: 300257
reactant: 300245
reactant: 300232
fast: false
reversible: true

300269
type: KineticLaw
local parameters: 052696
local parameters: 052693
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx

052696
type: LocalParameter
units: 284709
value: 6.8E-18

052693
type: LocalParameter
units: 284793
value: 8.7498E-18

300257
type: SpeciesReference
stoichiometry: 1.0
species: 564155

564155
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

300245
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300232
type: SpeciesReference
stoichiometry: 1.0
species: 565115

573454
type: Reaction
kinetic law: 302414
product: 302402
reactant: 302390
reactant: 302378
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

302414
type: KineticLaw
local parameters: 052864
local parameters: 052861
notes: k1*CaM_slash_neurogranin_minus_CaM_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx

052864
type: LocalParameter
units: 284709
value: 1.26E-16

052861
type: LocalParameter
units: 284793
value: 6.11982E-19

302402
type: SpeciesReference
stoichiometry: 1.0
species: 564615

302390
type: SpeciesReference
stoichiometry: 1.0
species: 564515

302378
type: SpeciesReference
stoichiometry: 1.0
species: 561095

570894
type: Reaction
kinetic law: 296105
product: 296093
reactant: 296081
reactant: 296069
fast: false
reversible: true

296105
type: KineticLaw
local parameters: 052420
local parameters: 052417
notes: k1*AMPAR_slash_A831_star_845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx

052420
type: LocalParameter
units: 284709
value: 2.16E-15

052417
type: LocalParameter
units: 284793
value: 3.5998992E-16

296093
type: SpeciesReference
stoichiometry: 1.0
species: 562995

296081
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296069
type: SpeciesReference
stoichiometry: 1.0
species: 564715

564715
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

573134
type: Reaction
kinetic law: 301623
product: 301611
reactant: 301599
reactant: 301587
fast: false
reversible: true

301623
type: KineticLaw
local parameters: 052794
local parameters: 052791
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx

052794
type: LocalParameter
units: 284709
value: 1.4E-17

052791
type: LocalParameter
units: 284793
value: 8.7498E-18

301611
type: SpeciesReference
stoichiometry: 1.0
species: 564435

301599
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301587
type: SpeciesReference
stoichiometry: 1.0
species: 565195

568935
type: Reaction
kinetic law: 290968
product: 290956
reactant: 290944
reactant: 290932
fast: false
reversible: true

290968
type: KineticLaw
local parameters: 052082
local parameters: 052079
notes: k1*PP1_slash_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx

052082
type: LocalParameter
units: 284709
value: 1.224E-16

052079
type: LocalParameter
units: 284793
value: 3.0779838E-17

290956
type: SpeciesReference
stoichiometry: 1.0
species: 561715

290944
type: SpeciesReference
stoichiometry: 1.0
species: 561675

290932
type: SpeciesReference
stoichiometry: 1.0
species: 561295

569474
type: Reaction
kinetic law: 292619
product: 292607
reactant: 292595
reactant: 292583
fast: false
reversible: true

292619
type: KineticLaw
local parameters: 052189
local parameters: 052186
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx

052189
type: LocalParameter
units: 284709
value: 7.2E-16

052186
type: LocalParameter
units: 284793
value: 1.8106416E-16

292607
type: SpeciesReference
stoichiometry: 1.0
species: 562055

292595
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292583
type: SpeciesReference
stoichiometry: 1.0
species: 564775

573094
type: Reaction
kinetic law: 301527
product: 301514
reactant: 301502
reactant: 301490
fast: false
reversible: true

301527
type: KineticLaw
local parameters: 052785
local parameters: 052782
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx

052785
type: LocalParameter
units: 284709
value: 1.4E-17

052782
type: LocalParameter
units: 284793
value: 8.7498E-18

301514
type: SpeciesReference
stoichiometry: 1.0
species: 564415

564415
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

301502
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301490
type: SpeciesReference
stoichiometry: 1.0
species: 565255

566815
type: Reaction
kinetic law: 285975
product: 285963
reactant: 285950
reactant: 285938
notes: This process is probably much more complicated and involves CaM. However, as I can\'t find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11
fast: false
reversible: true

285975
type: KineticLaw
local parameters: 051765
local parameters: 051763
notes: kf*Ca^2*PP2B_slash_CaNAB_minus_Ca2-kb*PP2B_slash_CaNAB_minus_Ca4

051765
type: LocalParameter
units: 284709
value: 9.0E-17

051763
type: LocalParameter
units: 284745
value: 3.24008424E-16

285963
type: SpeciesReference
stoichiometry: 1.0
species: 561615

285950
type: SpeciesReference
stoichiometry: 1.0
species: 561595

561595
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

285938
type: SpeciesReference
stoichiometry: 2.0
species: 560215

568035
type: Reaction
kinetic law: 288792
product: 288780
product: 288768
reactant: 288755
fast: false
reversible: false

288792
type: KineticLaw
local parameters: 051935
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx

051935
type: LocalParameter
units: 284709
value: 5.0E-18

288780
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288768
type: SpeciesReference
stoichiometry: 1.0
species: 565000

288755
type: SpeciesReference
stoichiometry: 1.0
species: 560775

568455
type: Reaction
kinetic law: 289808
product: 289796
reactant: 289784
reactant: 289772
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true

289808
type: KineticLaw
local parameters: 052000
local parameters: 051998
notes: k1*PP1_slash_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx

052000
type: LocalParameter
units: 284709
value: 7.50006E-16

051998
type: LocalParameter
units: 284793
value: 5.81256E-17

289796
type: SpeciesReference
stoichiometry: 1.0
species: 561375

289784
type: SpeciesReference
stoichiometry: 1.0
species: 561355

289772
type: SpeciesReference
stoichiometry: 1.0
species: 561295

570834
type: Reaction
kinetic law: 295961
product: 295949
product: 295936
reactant: 295924
fast: false
reversible: false

295961
type: KineticLaw
local parameters: 052409
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx

052409
type: LocalParameter
units: 284709
value: 5.4E-16

295949
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295936
type: SpeciesReference
stoichiometry: 1.0
species: 564815

295924
type: SpeciesReference
stoichiometry: 1.0
species: 562955

566555
type: Reaction
kinetic law: 285376
product: 285364
reactant: 285352
reactant: 285340
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true

285376
type: KineticLaw
local parameters: 051726
local parameters: 051724
notes: kf*CaM_slash_CaM*Ca^2-kb*CaM_slash_CaM_minus_TR2_minus_Ca2

051726
type: LocalParameter
units: 284709
value: 6.48E-15

051724
type: LocalParameter
units: 284745
value: 6.47990604E-15

285364
type: SpeciesReference
stoichiometry: 1.0
species: 561155

285352
type: SpeciesReference
stoichiometry: 2.0
species: 560215

285340
type: SpeciesReference
stoichiometry: 1.0
species: 560995

567435
type: Reaction
kinetic law: 287358
product: 287345
reactant: 287333
fast: false
reversible: true

287358
type: KineticLaw
local parameters: 051858
local parameters: 051856
notes: kf*PKC_minus_control-kb*PKC_minus_active

051858
type: LocalParameter
units: 284709
value: 2.25E-16

051856
type: LocalParameter
units: 284709
value: 2.25E-16

287345
type: SpeciesReference
stoichiometry: 1.0
species: 564515

287333
type: SpeciesReference
stoichiometry: 1.0
species: 565415

572814
type: Reaction
kinetic law: 300849
product: 300837
reactant: 300825
reactant: 300813
fast: false
reversible: true

300849
type: KineticLaw
local parameters: 052736
local parameters: 052733
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx

052736
type: LocalParameter
units: 284709
value: 1.4E-17

052733
type: LocalParameter
units: 284793
value: 8.7498E-18

300837
type: SpeciesReference
stoichiometry: 1.0
species: 564275

300825
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300813
type: SpeciesReference
stoichiometry: 1.0
species: 565235

567855
type: Reaction
kinetic law: 288356
product: 288344
reactant: 288332
reactant: 288320
fast: false
reversible: true

288356
type: KineticLaw
local parameters: 051914
local parameters: 051911
notes: k1*AMPAR_memb_slash_A_B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx

051914
type: LocalParameter
units: 284709
value: 2.0E-17

051911
type: LocalParameter
units: 284793
value: 2.77776E-19

288344
type: SpeciesReference
stoichiometry: 1.0
species: 560695

288332
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288320
type: SpeciesReference
stoichiometry: 1.0
species: 564975

565695
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

567155
type: Reaction
kinetic law: 286765
product: 286753
product: 286741
reactant: 286729
fast: false
reversible: true

286765
type: KineticLaw
local parameters: 051816
local parameters: 051814
notes: kf*AMPAR_memb_slash_A831_star__B831_star_-kb*AMPAR_slash_A831_star__B831_star_*AMPAR_memb_slash_Anchor

051816
type: LocalParameter
units: 284793
value: 0.0

051814
type: LocalParameter
units: 284709
value: 8.0E-21

286753
type: SpeciesReference
stoichiometry: 1.0
species: 565295

286741
type: SpeciesReference
stoichiometry: 1.0
species: 564915

286729
type: SpeciesReference
stoichiometry: 1.0
species: 565015

570474
type: Reaction
kinetic law: 295090
product: 295078
product: 295066
reactant: 295054
fast: false
reversible: false

295090
type: KineticLaw
local parameters: 052354
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx

052354
type: LocalParameter
units: 284709
value: 5.4E-16

295078
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295066
type: SpeciesReference
stoichiometry: 1.0
species: 564895

295054
type: SpeciesReference
stoichiometry: 1.0
species: 562775

569834
type: Reaction
kinetic law: 293541
product: 293529
product: 293517
reactant: 293505
fast: false
reversible: false

293541
type: KineticLaw
local parameters: 052247
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx

052247
type: LocalParameter
units: 284709
value: 1.8E-16

293529
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293517
type: SpeciesReference
stoichiometry: 1.0
species: 564995

293505
type: SpeciesReference
stoichiometry: 1.0
species: 562255

571114
type: Reaction
kinetic law: 296732
product: 296719
product: 296707
reactant: 296695
fast: false
reversible: false

296732
type: KineticLaw
local parameters: 052457
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx

052457
type: LocalParameter
units: 284709
value: 5.4E-16

296719
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296707
type: SpeciesReference
stoichiometry: 1.0
species: 565095

296695
type: SpeciesReference
stoichiometry: 1.0
species: 563115

572034
type: Reaction
kinetic law: 298963
product: 298951
product: 298939
reactant: 298927
fast: false
reversible: false

298963
type: KineticLaw
local parameters: 052604
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx

052604
type: LocalParameter
units: 284709
value: 1.7E-18

298951
type: SpeciesReference
stoichiometry: 1.0
species: 563755

298939
type: SpeciesReference
stoichiometry: 1.0
species: 565035

298927
type: SpeciesReference
stoichiometry: 1.0
species: 563875

567975
type: Reaction
kinetic law: 288646
product: 288634
reactant: 288622
reactant: 288610
fast: false
reversible: true

288646
type: KineticLaw
local parameters: 051929
local parameters: 051927
notes: k1*AMPAR_memb_slash_A845_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx

051929
type: LocalParameter
units: 284709
value: 2.0E-17

051927
type: LocalParameter
units: 284793
value: 2.77776E-19

288634
type: SpeciesReference
stoichiometry: 1.0
species: 560755

288622
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288610
type: SpeciesReference
stoichiometry: 1.0
species: 565035

570774
type: Reaction
kinetic law: 295815
product: 295802
reactant: 295790
reactant: 295778
fast: false
reversible: true

295815
type: KineticLaw
local parameters: 052402
local parameters: 052399
notes: k1*AMPAR_slash_A_B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx

052402
type: LocalParameter
units: 284709
value: 2.16E-15

052399
type: LocalParameter
units: 284793
value: 3.5998992E-16

295802
type: SpeciesReference
stoichiometry: 1.0
species: 562935

295790
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295778
type: SpeciesReference
stoichiometry: 1.0
species: 564835

568815
type: Reaction
kinetic law: 290677
product: 290665
reactant: 290653
reactant: 290641
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true

290677
type: KineticLaw
local parameters: 052064
local parameters: 052061
notes: k1*PP1_slash_I1_star_*PP2B_slash_CaNAB_minus_Ca4-k2*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx

052064
type: LocalParameter
units: 284709
value: 1.224E-17

052061
type: LocalParameter
units: 284793
value: 3.0779838E-18

290665
type: SpeciesReference
stoichiometry: 1.0
species: 561635

290653
type: SpeciesReference
stoichiometry: 1.0
species: 561615

290641
type: SpeciesReference
stoichiometry: 1.0
species: 561295

571174
type: Reaction
kinetic law: 296877
product: 296865
reactant: 296853
reactant: 296841
fast: false
reversible: true

296877
type: KineticLaw
local parameters: 052470
local parameters: 052467
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx

052470
type: LocalParameter
units: 284709
value: 2.16E-15

052467
type: LocalParameter
units: 284793
value: 3.999888E-17

296865
type: SpeciesReference
stoichiometry: 1.0
species: 563155

296853
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296841
type: SpeciesReference
stoichiometry: 1.0
species: 565055

569354
type: Reaction
kinetic law: 292224
product: 292212
reactant: 292200
reactant: 292188
fast: false
reversible: true

292224
type: KineticLaw
local parameters: 052162
local parameters: 052159
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx

052162
type: LocalParameter
units: 284709
value: 7.2E-16

052159
type: LocalParameter
units: 284793
value: 1.8106416E-16

292212
type: SpeciesReference
stoichiometry: 1.0
species: 561975

292200
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292188
type: SpeciesReference
stoichiometry: 1.0
species: 564775

567315
type: Reaction
kinetic law: 287102
product: 287090
reactant: 287078
reactant: 287066
fast: false
reversible: true

287102
type: KineticLaw
local parameters: 051840
local parameters: 051838
notes: kf*AMPAR_slash_A835_star_845_star__B835_star_845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_

051840
type: LocalParameter
units: 284709
value: 8.0E-20

051838
type: LocalParameter
units: 284793
value: 1.08E-19

287090
type: SpeciesReference
stoichiometry: 1.0
species: 565255

287078
type: SpeciesReference
stoichiometry: 1.0
species: 565295

287066
type: SpeciesReference
stoichiometry: 1.0
species: 564815

567035
type: Reaction
kinetic law: 286499
product: 286487
reactant: 286475
notes: Random rate.
fast: false
reversible: true

286499
type: KineticLaw
local parameters: 051798
local parameters: 051796
notes: kf*AC_slash_AC2_star_-kb*AC_slash_AC2

051798
type: LocalParameter
units: 284709
value: 0.0

051796
type: LocalParameter
units: 284709
value: 9.0E-18

286487
type: SpeciesReference
stoichiometry: 1.0
species: 563415

286475
type: SpeciesReference
stoichiometry: 1.0
species: 563395

571294
type: Reaction
kinetic law: 297167
product: 297155
reactant: 297143
reactant: 297131
fast: false
reversible: true

297167
type: KineticLaw
local parameters: 052491
local parameters: 052488
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx

052491
type: LocalParameter
units: 284709
value: 2.16E-15

052488
type: LocalParameter
units: 284793
value: 3.999888E-17

297155
type: SpeciesReference
stoichiometry: 1.0
species: 563215

297143
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297131
type: SpeciesReference
stoichiometry: 1.0
species: 565175

570354
type: Reaction
kinetic law: 294802
product: 294790
product: 294778
reactant: 294766
fast: false
reversible: false

294802
type: KineticLaw
local parameters: 052334
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx

052334
type: LocalParameter
units: 284709
value: 8.1E-16

294790
type: SpeciesReference
stoichiometry: 1.0
species: 562655

294778
type: SpeciesReference
stoichiometry: 1.0
species: 563695

294766
type: SpeciesReference
stoichiometry: 1.0
species: 562715

573114
type: Reaction
kinetic law: 301575
product: 301563
product: 301551
reactant: 301539
fast: false
reversible: false

301575
type: KineticLaw
local parameters: 052788
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx

052788
type: LocalParameter
units: 284709
value: 3.5E-18

301563
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301551
type: SpeciesReference
stoichiometry: 1.0
species: 565215

301539
type: SpeciesReference
stoichiometry: 1.0
species: 564415

568335
type: Reaction
kinetic law: 289520
product: 289508
reactant: 289495
reactant: 289483
fast: false
reversible: true

289520
type: KineticLaw
local parameters: 051976
local parameters: 051974
notes: k1*AMPAR_memb_slash_A831_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx

051976
type: LocalParameter
units: 284709
value: 2.0E-17

051974
type: LocalParameter
units: 284793
value: 2.77776E-19

289508
type: SpeciesReference
stoichiometry: 1.0
species: 560935

289495
type: SpeciesReference
stoichiometry: 1.0
species: 565595

289483
type: SpeciesReference
stoichiometry: 1.0
species: 564995

570714
type: Reaction
kinetic law: 295670
product: 295658
product: 295646
reactant: 295634
fast: false
reversible: false

295670
type: KineticLaw
local parameters: 052391
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx

052391
type: LocalParameter
units: 284709
value: 5.4E-16

295658
type: SpeciesReference
stoichiometry: 1.0
species: 562655

295646
type: SpeciesReference
stoichiometry: 1.0
species: 564755

295634
type: SpeciesReference
stoichiometry: 1.0
species: 562895

566435
type: Reaction
kinetic law: 285096
product: 285083
reactant: 285071
reactant: 285059
notes: Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers
fast: false
reversible: true

285096
type: KineticLaw
local parameters: 051708
local parameters: 051706
notes: kf*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_NMDAR-kb*CaMKII_slash_CaMKII_minus_CaM_minus_PSD

051708
type: LocalParameter
units: 284709
value: 0.0

051706
type: LocalParameter
units: 284793
value: 1.08E-20

285083
type: SpeciesReference
stoichiometry: 1.0
species: 560535

285071
type: SpeciesReference
stoichiometry: 1.0
species: 560495

285059
type: SpeciesReference
stoichiometry: 1.0
species: 560255

569714
type: Reaction
kinetic law: 293249
product: 293237
product: 293225
reactant: 293213
fast: false
reversible: false

293249
type: KineticLaw
local parameters: 052229
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx

052229
type: LocalParameter
units: 284709
value: 1.8E-16

293237
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293225
type: SpeciesReference
stoichiometry: 1.0
species: 564975

293213
type: SpeciesReference
stoichiometry: 1.0
species: 562195

568395
type: Reaction
kinetic law: 289664
product: 289652
product: 289640
reactant: 289628
fast: false
reversible: false

289664
type: KineticLaw
local parameters: 051987
notes: k3*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx

051987
type: LocalParameter
units: 284709
value: 6.0E-17

289652
type: SpeciesReference
stoichiometry: 1.0
species: 565615

289640
type: SpeciesReference
stoichiometry: 1.0
species: 560455

289628
type: SpeciesReference
stoichiometry: 1.0
species: 560955

572594
type: Reaction
kinetic law: 300318
product: 300306
product: 300294
reactant: 300281
fast: false
reversible: false

300318
type: KineticLaw
local parameters: 052697
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx

052697
type: LocalParameter
units: 284709
value: 1.7E-18

300306
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300294
type: SpeciesReference
stoichiometry: 1.0
species: 565000

300281
type: SpeciesReference
stoichiometry: 1.0
species: 564155

567235
type: Reaction
kinetic law: 286946
product: 286934
reactant: 286922
fast: false
reversible: true

286946
type: KineticLaw
local parameters: 051828
local parameters: 051826
notes: kf*AMPAR_slash_A835_star_845_star__B835_star_845_star_-kb*AMPAR_slash_AMPAR_deg

051828
type: LocalParameter
units: 284709
value: 0.0

051826
type: LocalParameter
units: 284709
value: 3.24E-21

286934
type: SpeciesReference
stoichiometry: 1.0
species: 565375

286922
type: SpeciesReference
stoichiometry: 1.0
species: 564815

572294
type: Reaction
kinetic law: 299592
product: 299580
reactant: 299568
reactant: 299556
fast: false
reversible: true

299592
type: KineticLaw
local parameters: 052649
local parameters: 052646
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx

052649
type: LocalParameter
units: 284709
value: 1.4E-17

052646
type: LocalParameter
units: 284793
value: 8.7498E-18

299580
type: SpeciesReference
stoichiometry: 1.0
species: 564015

299568
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299556
type: SpeciesReference
stoichiometry: 1.0
species: 565215

573154
type: Reaction
kinetic law: 301671
product: 301659
product: 301647
reactant: 301635
fast: false
reversible: false

301671
type: KineticLaw
local parameters: 052797
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx

052797
type: LocalParameter
units: 284709
value: 3.5E-18

301659
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301647
type: SpeciesReference
stoichiometry: 1.0
species: 565155

301635
type: SpeciesReference
stoichiometry: 1.0
species: 564435

573434
type: Reaction
kinetic law: 302366
product: 302354
product: 302342
reactant: 302330
fast: false
reversible: false

302366
type: KineticLaw
local parameters: 052858
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx

052858
type: LocalParameter
units: 284709
value: 5.22E-17

302354
type: SpeciesReference
stoichiometry: 1.0
species: 564515

302342
type: SpeciesReference
stoichiometry: 1.0
species: 561135

302330
type: SpeciesReference
stoichiometry: 1.0
species: 564595

571054
type: Reaction
kinetic law: 296586
product: 296574
reactant: 296562
reactant: 296550
fast: false
reversible: true

296586
type: KineticLaw
local parameters: 052450
local parameters: 052447
notes: k1*AMPAR_memb_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx

052450
type: LocalParameter
units: 284709
value: 2.16E-15

052447
type: LocalParameter
units: 284793
value: 3.999888E-17

296574
type: SpeciesReference
stoichiometry: 1.0
species: 563095

296562
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296550
type: SpeciesReference
stoichiometry: 1.0
species: 564975

569134
type: Reaction
kinetic law: 291452
product: 291440
reactant: 291428
reactant: 291416
fast: false
reversible: true

291452
type: KineticLaw
local parameters: 052112
local parameters: 052109
notes: k1*AMPAR_slash_A831_star_845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx

052112
type: LocalParameter
units: 284709
value: 7.2E-16

052109
type: LocalParameter
units: 284793
value: 1.8106416E-16

291440
type: SpeciesReference
stoichiometry: 1.0
species: 561815

291428
type: SpeciesReference
stoichiometry: 1.0
species: 561675

291416
type: SpeciesReference
stoichiometry: 1.0
species: 564715

571474
type: Reaction
kinetic law: 297610
product: 297598
product: 297586
reactant: 297574
fast: false
reversible: false

297610
type: KineticLaw
local parameters: 052517
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx

052517
type: LocalParameter
units: 284709
value: 5.4E-16

297598
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297586
type: SpeciesReference
stoichiometry: 1.0
species: 565255

297574
type: SpeciesReference
stoichiometry: 1.0
species: 563295

572074
type: Reaction
kinetic law: 299060
product: 299047
product: 299035
reactant: 299023
fast: false
reversible: false

299060
type: KineticLaw
local parameters: 052611
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx

052611
type: LocalParameter
units: 284709
value: 1.7E-18

299047
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299035
type: SpeciesReference
stoichiometry: 1.0
species: 564975

299023
type: SpeciesReference
stoichiometry: 1.0
species: 563895

570234
type: Reaction
kinetic law: 294512
product: 294500
product: 294488
reactant: 294475
fast: false
reversible: false

294512
type: KineticLaw
local parameters: 052313
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx

052313
type: LocalParameter
units: 284709
value: 6.03E-17

294500
type: SpeciesReference
stoichiometry: 1.0
species: 561675

294488
type: SpeciesReference
stoichiometry: 1.0
species: 561115

294475
type: SpeciesReference
stoichiometry: 1.0
species: 562455

567675
type: Reaction
kinetic law: 287922
product: 287910
product: 287898
reactant: 287886
fast: false
reversible: false

287922
type: KineticLaw
local parameters: 051889
notes: k3*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx

051889
type: LocalParameter
units: 284709
value: 6.0E-17

287910
type: SpeciesReference
stoichiometry: 1.0
species: 565555

287898
type: SpeciesReference
stoichiometry: 1.0
species: 560455

287886
type: SpeciesReference
stoichiometry: 1.0
species: 560575

573314
type: Reaction
kinetic law: 302066
product: 302054
product: 302042
reactant: 302030
fast: false
reversible: false

302066
type: KineticLaw
local parameters: 052833
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx

052833
type: LocalParameter
units: 284709
value: 5.22E-17

302054
type: SpeciesReference
stoichiometry: 1.0
species: 564515

302042
type: SpeciesReference
stoichiometry: 1.0
species: 561035

302030
type: SpeciesReference
stoichiometry: 1.0
species: 564535

569854
type: Reaction
kinetic law: 293590
product: 293577
reactant: 293565
reactant: 293553
fast: false
reversible: true

293590
type: KineticLaw
local parameters: 052252
local parameters: 052249
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx

052252
type: LocalParameter
units: 284709
value: 7.2E-16

052249
type: LocalParameter
units: 284793
value: 2.011824E-17

293577
type: SpeciesReference
stoichiometry: 1.0
species: 562275

293565
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293553
type: SpeciesReference
stoichiometry: 1.0
species: 565055

572634
type: Reaction
kinetic law: 300415
product: 300403
product: 300391
reactant: 300379
fast: false
reversible: false

300415
type: KineticLaw
local parameters: 052703
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx

052703
type: LocalParameter
units: 284709
value: 1.7E-18

300403
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300391
type: SpeciesReference
stoichiometry: 1.0
species: 565195

300379
type: SpeciesReference
stoichiometry: 1.0
species: 564175

571594
type: Reaction
kinetic law: 297899
product: 297887
product: 297875
reactant: 297863
fast: false
reversible: false

297899
type: KineticLaw
local parameters: 052535
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx

052535
type: LocalParameter
units: 284709
value: 5.4E-16

297887
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297875
type: SpeciesReference
stoichiometry: 1.0
species: 565075

297863
type: SpeciesReference
stoichiometry: 1.0
species: 563355

572474
type: Reaction
kinetic law: 300028
product: 300016
product: 300004
reactant: 299992
fast: false
reversible: false

300028
type: KineticLaw
local parameters: 052677
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx

052677
type: LocalParameter
units: 284709
value: 1.7E-18

300016
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300004
type: SpeciesReference
stoichiometry: 1.0
species: 565175

299992
type: SpeciesReference
stoichiometry: 1.0
species: 564095

569295
type: Reaction
kinetic law: 292079
product: 292067
product: 292055
reactant: 292043
fast: false
reversible: false

292079
type: KineticLaw
local parameters: 052150
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx

052150
type: LocalParameter
units: 284709
value: 1.8E-16

292067
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292055
type: SpeciesReference
stoichiometry: 1.0
species: 564915

292043
type: SpeciesReference
stoichiometry: 1.0
species: 561935

567955
type: Reaction
kinetic law: 288598
product: 288586
product: 288574
reactant: 288562
fast: false
reversible: false

288598
type: KineticLaw
local parameters: 051925
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx

051925
type: LocalParameter
units: 284709
value: 5.0E-18

288586
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288574
type: SpeciesReference
stoichiometry: 1.0
species: 565175

288562
type: SpeciesReference
stoichiometry: 1.0
species: 560735

571714
type: Reaction
kinetic law: 298187
product: 298175
product: 298163
reactant: 298151
fast: false
reversible: false

298187
type: KineticLaw
local parameters: 052553
notes: k3*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx

052553
type: LocalParameter
units: 284709
value: 1.8E-15

298175
type: SpeciesReference
stoichiometry: 1.0
species: 563495

298163
type: SpeciesReference
stoichiometry: 1.0
species: 563435

298151
type: SpeciesReference
stoichiometry: 1.0
species: 563515

568835
type: Reaction
kinetic law: 290726
product: 290713
product: 290701
reactant: 290689
fast: false
reversible: false

290726
type: KineticLaw
local parameters: 052065
notes: k3*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx

052065
type: LocalParameter
units: 284709
value: 3.06E-18

290713
type: SpeciesReference
stoichiometry: 1.0
species: 561615

290701
type: SpeciesReference
stoichiometry: 1.0
species: 561275

290689
type: SpeciesReference
stoichiometry: 1.0
species: 561635

566935
type: Reaction
kinetic law: 286267
product: 286255
reactant: 286243
reactant: 286231
fast: false
reversible: true

286267
type: KineticLaw
local parameters: 051783
local parameters: 051781
notes: kf*AC_slash_cAMP*PKA_slash_R2C2_minus_cAMP3-kb*PKA_slash_R2C2_minus_cAMP4

051783
type: LocalParameter
units: 284709
value: 2.925E-15

051781
type: LocalParameter
units: 284793
value: 6.750054E-15

286255
type: SpeciesReference
stoichiometry: 1.0
species: 562555

562555
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

286243
type: SpeciesReference
stoichiometry: 1.0
species: 562535

286231
type: SpeciesReference
stoichiometry: 1.0
species: 563635

569334
type: Reaction
kinetic law: 292176
product: 292164
product: 292152
reactant: 292140
fast: false
reversible: false

292176
type: KineticLaw
local parameters: 052157
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx

052157
type: LocalParameter
units: 284709
value: 1.8E-16

292164
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292152
type: SpeciesReference
stoichiometry: 1.0
species: 564735

292140
type: SpeciesReference
stoichiometry: 1.0
species: 561955

570414
type: Reaction
kinetic law: 294946
product: 294934
reactant: 294922
reactant: 294910
fast: false
reversible: true

294946
type: KineticLaw
local parameters: 052347
local parameters: 052344
notes: k1*AMPAR_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx

052347
type: LocalParameter
units: 284709
value: 2.16E-15

052344
type: LocalParameter
units: 284793
value: 3.5998992E-16

294934
type: SpeciesReference
stoichiometry: 1.0
species: 562755

294922
type: SpeciesReference
stoichiometry: 1.0
species: 562655

294910
type: SpeciesReference
stoichiometry: 1.0
species: 564675

566455
type: Reaction
kinetic law: 285144
product: 285132
reactant: 285120
reactant: 285108
notes: Same as for transloc_1
fast: false
reversible: true

285144
type: KineticLaw
local parameters: 051711
local parameters: 051709
notes: kf*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*CaMKII_slash_NMDAR-kb*CaMKII_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD

051711
type: LocalParameter
units: 284709
value: 0.0

051709
type: LocalParameter
units: 284793
value: 1.08E-20

285132
type: SpeciesReference
stoichiometry: 1.0
species: 560555

285120
type: SpeciesReference
stoichiometry: 1.0
species: 560495

285108
type: SpeciesReference
stoichiometry: 1.0
species: 560275

569734
type: Reaction
kinetic law: 293298
product: 293285
reactant: 293273
reactant: 293261
fast: false
reversible: true

293298
type: KineticLaw
local parameters: 052234
local parameters: 052231
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx

052234
type: LocalParameter
units: 284709
value: 7.2E-16

052231
type: LocalParameter
units: 284793
value: 2.011824E-17

293285
type: SpeciesReference
stoichiometry: 1.0
species: 562215

293273
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293261
type: SpeciesReference
stoichiometry: 1.0
species: 565215

569454
type: Reaction
kinetic law: 292571
product: 292559
product: 292547
reactant: 292535
fast: false
reversible: false

292571
type: KineticLaw
local parameters: 052183
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx

052183
type: LocalParameter
units: 284709
value: 1.8E-16

292559
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292547
type: SpeciesReference
stoichiometry: 1.0
species: 564695

292535
type: SpeciesReference
stoichiometry: 1.0
species: 562035

565655
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560155

572354
type: Reaction
kinetic law: 299737
product: 299725
product: 299713
reactant: 299701
fast: false
reversible: false

299737
type: KineticLaw
local parameters: 052656
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx

052656
type: LocalParameter
units: 284709
value: 3.5E-18

299725
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299713
type: SpeciesReference
stoichiometry: 1.0
species: 565095

299701
type: SpeciesReference
stoichiometry: 1.0
species: 564035

571914
type: Reaction
kinetic law: 298674
product: 298662
product: 298650
reactant: 298637
fast: false
reversible: false

298674
type: KineticLaw
local parameters: 052585
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

052585
type: LocalParameter
units: 284709
value: 2.5E-17

298662
type: SpeciesReference
stoichiometry: 1.0
species: 563755

298650
type: SpeciesReference
stoichiometry: 1.0
species: 560515

298637
type: SpeciesReference
stoichiometry: 1.0
species: 563815

573234
type: Reaction
kinetic law: 301864
product: 301852
product: 301840
reactant: 301828
fast: false
reversible: false

301864
type: KineticLaw
local parameters: 052815
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx

052815
type: LocalParameter
units: 284709
value: 3.5E-18

301852
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301840
type: SpeciesReference
stoichiometry: 1.0
species: 564995

301828
type: SpeciesReference
stoichiometry: 1.0
species: 564475

561575
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 560155

567115
type: Reaction
kinetic law: 286668
product: 286656
product: 286644
reactant: 286632
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true

286668
type: KineticLaw
local parameters: 051810
local parameters: 051808
notes: kf*PP1_PSD_slash_PP1_minus_I1-kb*PP1_PSD_slash_I1*PP1_PSD_slash_PP1_minus_active_PSD

051810
type: LocalParameter
units: 284793
value: 0.0

051808
type: LocalParameter
units: 284709
value: 1.0E-17

286656
type: SpeciesReference
stoichiometry: 1.0
species: 563755

286644
type: SpeciesReference
stoichiometry: 1.0
species: 563675

286632
type: SpeciesReference
stoichiometry: 1.0
species: 563735

568715
type: Reaction
kinetic law: 290436
product: 290424
product: 290412
reactant: 290400
fast: false
reversible: false

290436
type: KineticLaw
local parameters: 052044
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

052044
type: LocalParameter
units: 284709
value: 2.25E-16

290424
type: SpeciesReference
stoichiometry: 1.0
species: 561455

290412
type: SpeciesReference
stoichiometry: 1.0
species: 560315

290400
type: SpeciesReference
stoichiometry: 1.0
species: 561515

572994
type: Reaction
kinetic law: 301284
product: 301272
product: 301260
reactant: 301248
fast: false
reversible: false

301284
type: KineticLaw
local parameters: 052763
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx

052763
type: LocalParameter
units: 284709
value: 3.5E-18

301272
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301260
type: SpeciesReference
stoichiometry: 1.0
species: 565175

301248
type: SpeciesReference
stoichiometry: 1.0
species: 564355

569475
type: Reaction
kinetic law: 292667
product: 292655
product: 292643
reactant: 292631
fast: false
reversible: false

292667
type: KineticLaw
local parameters: 052190
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx

052190
type: LocalParameter
units: 284709
value: 1.8E-16

292655
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292643
type: SpeciesReference
stoichiometry: 1.0
species: 564715

292631
type: SpeciesReference
stoichiometry: 1.0
species: 562055

567835
type: Reaction
kinetic law: 288308
product: 288296
product: 288284
reactant: 288272
fast: false
reversible: false

288308
type: KineticLaw
local parameters: 051909
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx

051909
type: LocalParameter
units: 284709
value: 5.0E-18

288296
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288284
type: SpeciesReference
stoichiometry: 1.0
species: 565055

288272
type: SpeciesReference
stoichiometry: 1.0
species: 560675

568235
type: Reaction
kinetic law: 289277
product: 289265
product: 289253
reactant: 289241
fast: false
reversible: false

289277
type: KineticLaw
local parameters: 051962
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx

051962
type: LocalParameter
units: 284709
value: 5.0E-18

289265
type: SpeciesReference
stoichiometry: 1.0
species: 565595

289253
type: SpeciesReference
stoichiometry: 1.0
species: 565255

289241
type: SpeciesReference
stoichiometry: 1.0
species: 560875

571494
type: Reaction
kinetic law: 297658
product: 297646
reactant: 297634
reactant: 297622
fast: false
reversible: true

297658
type: KineticLaw
local parameters: 052522
local parameters: 052519
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx

052522
type: LocalParameter
units: 284709
value: 2.16E-15

052519
type: LocalParameter
units: 284793
value: 3.999888E-17

297646
type: SpeciesReference
stoichiometry: 1.0
species: 563315

297634
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297622
type: SpeciesReference
stoichiometry: 1.0
species: 565075

565895
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

572094
type: Reaction
kinetic law: 299110
product: 299098
reactant: 299085
reactant: 299074
fast: false
reversible: true

299110
type: KineticLaw
local parameters: 052617
local parameters: 052614
notes: k1*AMPAR_memb_slash_A_B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx

052617
type: LocalParameter
units: 284709
value: 6.8E-18

052614
type: LocalParameter
units: 284793
value: 8.7498E-18

299098
type: SpeciesReference
stoichiometry: 1.0
species: 563915

299085
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299074
type: SpeciesReference
stoichiometry: 1.0
species: 565095

568295
type: Reaction
kinetic law: 289422
product: 289410
reactant: 289398
reactant: 289386
fast: false
reversible: true

289422
type: KineticLaw
local parameters: 051971
local parameters: 051969
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx

051971
type: LocalParameter
units: 284709
value: 2.0E-17

051969
type: LocalParameter
units: 284793
value: 2.77776E-19

289410
type: SpeciesReference
stoichiometry: 1.0
species: 560915

289398
type: SpeciesReference
stoichiometry: 1.0
species: 565595

289386
type: SpeciesReference
stoichiometry: 1.0
species: 565055

565515
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 22.0
initial amount: NaN
in compartment: 560155

568095
type: Reaction
kinetic law: 288938
product: 288925
reactant: 288913
reactant: 288901
fast: false
reversible: true

288938
type: KineticLaw
local parameters: 051945
local parameters: 051943
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx

051945
type: LocalParameter
units: 284709
value: 2.0E-17

051943
type: LocalParameter
units: 284793
value: 2.77776E-19

288925
type: SpeciesReference
stoichiometry: 1.0
species: 560815

288913
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288901
type: SpeciesReference
stoichiometry: 1.0
species: 565175

573334
type: Reaction
kinetic law: 302114
product: 302102
reactant: 302090
reactant: 302078
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

302114
type: KineticLaw
local parameters: 052839
local parameters: 052836
notes: k1*CaM_slash_neurogranin_minus_CaM*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx

052839
type: LocalParameter
units: 284709
value: 1.26E-16

052836
type: LocalParameter
units: 284793
value: 5.507838E-18

302102
type: SpeciesReference
stoichiometry: 1.0
species: 564555

302090
type: SpeciesReference
stoichiometry: 1.0
species: 564515

302078
type: SpeciesReference
stoichiometry: 1.0
species: 561015

566835
type: Reaction
kinetic law: 286024
product: 286012
reactant: 285999
reactant: 285987
notes: going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1.
fast: false
reversible: true

286024
type: KineticLaw
local parameters: 051768
local parameters: 051766
notes: kf*PP2B_slash_CaNAB*Ca^2-kb*PP2B_slash_CaNAB_minus_Ca2

051768
type: LocalParameter
units: 284709
value: 9.0E-17

051766
type: LocalParameter
units: 284745
value: 9.00720324E-13

286012
type: SpeciesReference
stoichiometry: 1.0
species: 561595

285999
type: SpeciesReference
stoichiometry: 2.0
species: 560215

285987
type: SpeciesReference
stoichiometry: 1.0
species: 561575

567715
type: Reaction
kinetic law: 288020
product: 288008
product: 287996
reactant: 287983
fast: false
reversible: false

288020
type: KineticLaw
local parameters: 051894
notes: k3*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx

051894
type: LocalParameter
units: 284709
value: 5.0E-18

288008
type: SpeciesReference
stoichiometry: 1.0
species: 565555

287996
type: SpeciesReference
stoichiometry: 1.0
species: 560555

287983
type: SpeciesReference
stoichiometry: 1.0
species: 560595

570314
type: Reaction
kinetic law: 294706
product: 294694
product: 294682
reactant: 294670
fast: false
reversible: false

294706
type: KineticLaw
local parameters: 052327
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx

052327
type: LocalParameter
units: 284709
value: 8.1E-16

294694
type: SpeciesReference
stoichiometry: 1.0
species: 562655

294682
type: SpeciesReference
stoichiometry: 1.0
species: 561295

294670
type: SpeciesReference
stoichiometry: 1.0
species: 562695

572454
type: Reaction
kinetic law: 299980
product: 299968
reactant: 299956
reactant: 299944
fast: false
reversible: true

299980
type: KineticLaw
local parameters: 052674
local parameters: 052671
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx

052674
type: LocalParameter
units: 284709
value: 6.8E-18

052671
type: LocalParameter
units: 284793
value: 8.7498E-18

299968
type: SpeciesReference
stoichiometry: 1.0
species: 564095

299956
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299944
type: SpeciesReference
stoichiometry: 1.0
species: 565235

572874
type: Reaction
kinetic law: 300995
product: 300983
product: 300971
reactant: 300958
fast: false
reversible: false

300995
type: KineticLaw
local parameters: 052743
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx

052743
type: LocalParameter
units: 284709
value: 3.5E-18

300983
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300971
type: SpeciesReference
stoichiometry: 1.0
species: 565035

300958
type: SpeciesReference
stoichiometry: 1.0
species: 564295

571374
type: Reaction
kinetic law: 297366
product: 297353
reactant: 297340
reactant: 297327
fast: false
reversible: true

297366
type: KineticLaw
local parameters: 052503
local parameters: 052500
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx

052503
type: LocalParameter
units: 284709
value: 2.16E-15

052500
type: LocalParameter
units: 284793
value: 3.999888E-17

297353
type: SpeciesReference
stoichiometry: 1.0
species: 563255

297340
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297327
type: SpeciesReference
stoichiometry: 1.0
species: 565000

566955
type: Reaction
kinetic law: 286315
product: 286303
product: 286291
reactant: 286279
notes: This has to be fast, as the activation of PKA by cAMP is also fast. kf was 10
fast: false
reversible: true

286315
type: KineticLaw
local parameters: 051786
local parameters: 051784
notes: kf*PKA_slash_R2C2_minus_cAMP4-kb*PKA_slash_PKA_minus_active*PKA_slash_R2C_minus_cAMP4

051786
type: LocalParameter
units: 284793
value: 1.6199838E-15

051784
type: LocalParameter
units: 284709
value: 5.4E-15

286303
type: SpeciesReference
stoichiometry: 1.0
species: 562575

286291
type: SpeciesReference
stoichiometry: 1.0
species: 562655

286279
type: SpeciesReference
stoichiometry: 1.0
species: 562555

572254
type: Reaction
kinetic law: 299495
product: 299483
reactant: 299471
reactant: 299459
fast: false
reversible: true

299495
type: KineticLaw
local parameters: 052643
local parameters: 052640
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx

052643
type: LocalParameter
units: 284709
value: 6.8E-18

052640
type: LocalParameter
units: 284793
value: 8.7498E-18

299483
type: SpeciesReference
stoichiometry: 1.0
species: 563995

299471
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299459
type: SpeciesReference
stoichiometry: 1.0
species: 565055

569774
type: Reaction
kinetic law: 293396
product: 293384
reactant: 293372
reactant: 293359
fast: false
reversible: true

293396
type: KineticLaw
local parameters: 052240
local parameters: 052237
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx

052240
type: LocalParameter
units: 284709
value: 7.2E-16

052237
type: LocalParameter
units: 284793
value: 2.011824E-17

293384
type: SpeciesReference
stoichiometry: 1.0
species: 562235

293372
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293359
type: SpeciesReference
stoichiometry: 1.0
species: 565215

567735
type: Reaction
kinetic law: 288068
product: 288056
reactant: 288044
reactant: 288032
fast: false
reversible: true

288068
type: KineticLaw
local parameters: 051898
local parameters: 051896
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx

051898
type: LocalParameter
units: 284709
value: 2.0E-17

051896
type: LocalParameter
units: 284793
value: 2.77776E-19

288056
type: SpeciesReference
stoichiometry: 1.0
species: 560635

288044
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288032
type: SpeciesReference
stoichiometry: 1.0
species: 565135

573274
type: Reaction
kinetic law: 301969
product: 301956
product: 301943
reactant: 301929
fast: false
reversible: false

301969
type: KineticLaw
local parameters: 052824
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

052824
type: LocalParameter
units: 284709
value: 2.5E-17

301956
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301943
type: SpeciesReference
stoichiometry: 1.0
species: 560475

301929
type: SpeciesReference
stoichiometry: 1.0
species: 564495

570434
type: Reaction
kinetic law: 294994
product: 294982
product: 294970
reactant: 294958
fast: false
reversible: false

294994
type: KineticLaw
local parameters: 052348
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx

052348
type: LocalParameter
units: 284709
value: 5.4E-16

294982
type: SpeciesReference
stoichiometry: 1.0
species: 562655

294970
type: SpeciesReference
stoichiometry: 1.0
species: 564715

294958
type: SpeciesReference
stoichiometry: 1.0
species: 562755

566715
type: Reaction
kinetic law: 285743
product: 285731
reactant: 285719
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true

285743
type: KineticLaw
local parameters: 051750
local parameters: 051748
notes: kf*CaM_slash_neurogranin_star__PSD-kb*CaM_slash_neurogranin_PSD

051750
type: LocalParameter
units: 284709
value: 0.0

051748
type: LocalParameter
units: 284709
value: 5.0E-20

285731
type: SpeciesReference
stoichiometry: 1.0
species: 561115

285719
type: SpeciesReference
stoichiometry: 1.0
species: 561135

567255
type: Reaction
kinetic law: 286982
product: 286970
reactant: 286958
fast: false
reversible: true

286982
type: KineticLaw
local parameters: 051831
local parameters: 051829
notes: kf*AMPAR_slash_A845_star__B831_star_845_star_-kb*AMPAR_slash_AMPAR_deg

051831
type: LocalParameter
units: 284709
value: 0.0

051829
type: LocalParameter
units: 284709
value: 3.24E-21

286970
type: SpeciesReference
stoichiometry: 1.0
species: 565375

286958
type: SpeciesReference
stoichiometry: 1.0
species: 564795

566695
type: Reaction
kinetic law: 285707
product: 285695
reactant: 285683
reactant: 285670
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true

285707
type: KineticLaw
local parameters: 051747
local parameters: 051745
notes: kf*CaM_slash_neurogranin_PSD*CaM_slash_CaM_minus_PSD-kb*CaM_slash_neurogranin_minus_CaM_PSD

051747
type: LocalParameter
units: 284709
value: 1.0E-17

051745
type: LocalParameter
units: 284793
value: 3.0E-18

285695
type: SpeciesReference
stoichiometry: 1.0
species: 561095

285683
type: SpeciesReference
stoichiometry: 1.0
species: 561075

285670
type: SpeciesReference
stoichiometry: 1.0
species: 561115

569974
type: Reaction
kinetic law: 293881
product: 293869
reactant: 293857
reactant: 293844
fast: false
reversible: true

293881
type: KineticLaw
local parameters: 052270
local parameters: 052267
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx

052270
type: LocalParameter
units: 284709
value: 7.2E-16

052267
type: LocalParameter
units: 284793
value: 2.011824E-17

293869
type: SpeciesReference
stoichiometry: 1.0
species: 562335

293857
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293844
type: SpeciesReference
stoichiometry: 1.0
species: 565175

572174
type: Reaction
kinetic law: 299303
product: 299291
reactant: 299279
reactant: 299267
fast: false
reversible: true

299303
type: KineticLaw
local parameters: 052630
local parameters: 052627
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx

052630
type: LocalParameter
units: 284709
value: 6.8E-18

052627
type: LocalParameter
units: 284793
value: 8.7498E-18

299291
type: SpeciesReference
stoichiometry: 1.0
species: 563955

299279
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299267
type: SpeciesReference
stoichiometry: 1.0
species: 565215

572334
type: Reaction
kinetic law: 299689
product: 299676
reactant: 299664
reactant: 299652
fast: false
reversible: true

299689
type: KineticLaw
local parameters: 052655
local parameters: 052652
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx

052655
type: LocalParameter
units: 284709
value: 1.4E-17

052652
type: LocalParameter
units: 284793
value: 8.7498E-18

299676
type: SpeciesReference
stoichiometry: 1.0
species: 564035

299664
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299652
type: SpeciesReference
stoichiometry: 1.0
species: 565155

572754
type: Reaction
kinetic law: 300705
product: 300693
product: 300681
reactant: 300669
fast: false
reversible: false

300705
type: KineticLaw
local parameters: 052723
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx

052723
type: LocalParameter
units: 284709
value: 1.7E-18

300693
type: SpeciesReference
stoichiometry: 1.0
species: 563755

300681
type: SpeciesReference
stoichiometry: 1.0
species: 565015

300669
type: SpeciesReference
stoichiometry: 1.0
species: 564235

573214
type: Reaction
kinetic law: 301816
product: 301803
reactant: 301791
reactant: 301779
fast: false
reversible: true

301816
type: KineticLaw
local parameters: 052812
local parameters: 052809
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx

052812
type: LocalParameter
units: 284709
value: 1.4E-17

052809
type: LocalParameter
units: 284793
value: 8.7498E-18

301803
type: SpeciesReference
stoichiometry: 1.0
species: 564475

301791
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301779
type: SpeciesReference
stoichiometry: 1.0
species: 565015

569654
type: Reaction
kinetic law: 293104
product: 293092
reactant: 293080
reactant: 293068
fast: false
reversible: true

293104
type: KineticLaw
local parameters: 052221
local parameters: 052218
notes: k1*AMPAR_memb_slash_A_B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx

052221
type: LocalParameter
units: 284709
value: 7.2E-16

052218
type: LocalParameter
units: 284793
value: 2.011824E-17

293092
type: SpeciesReference
stoichiometry: 1.0
species: 562175

293080
type: SpeciesReference
stoichiometry: 1.0
species: 561675

293068
type: SpeciesReference
stoichiometry: 1.0
species: 565095

567495
type: Reaction
kinetic law: 287479
product: 287467
reactant: 287454
reactant: 287442
notes: Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
fast: false
reversible: true

287479
type: KineticLaw
local parameters: 051867
local parameters: 051865
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx

051867
type: LocalParameter
units: 284709
value: 2.16E-15

051865
type: LocalParameter
units: 284793
value: 2.3767344E-17

287467
type: SpeciesReference
stoichiometry: 1.0
species: 560335

287454
type: SpeciesReference
stoichiometry: 1.0
species: 565475

287442
type: SpeciesReference
stoichiometry: 1.0
species: 560315

571254
type: Reaction
kinetic law: 297071
product: 297058
reactant: 297046
reactant: 297034
fast: false
reversible: true

297071
type: KineticLaw
local parameters: 052484
local parameters: 052481
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx

052484
type: LocalParameter
units: 284709
value: 2.16E-15

052481
type: LocalParameter
units: 284793
value: 3.999888E-17

297058
type: SpeciesReference
stoichiometry: 1.0
species: 563195

297046
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297034
type: SpeciesReference
stoichiometry: 1.0
species: 564995

567915
type: Reaction
kinetic law: 288502
product: 288490
product: 288478
reactant: 288466
fast: false
reversible: false

288502
type: KineticLaw
local parameters: 051920
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx

051920
type: LocalParameter
units: 284709
value: 5.0E-18

288490
type: SpeciesReference
stoichiometry: 1.0
species: 565595

288478
type: SpeciesReference
stoichiometry: 1.0
species: 565235

288466
type: SpeciesReference
stoichiometry: 1.0
species: 560715

570114
type: Reaction
kinetic law: 294221
product: 294209
product: 294196
reactant: 294184
fast: false
reversible: false

294221
type: KineticLaw
local parameters: 052292
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx

052292
type: LocalParameter
units: 284709
value: 1.8E-16

294209
type: SpeciesReference
stoichiometry: 1.0
species: 561675

294196
type: SpeciesReference
stoichiometry: 1.0
species: 565075

294184
type: SpeciesReference
stoichiometry: 1.0
species: 562395

566575
type: Reaction
kinetic law: 285426
product: 285414
reactant: 285401
reactant: 285388
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true

285426
type: KineticLaw
local parameters: 051729
local parameters: 051727
notes: kf*CaM_slash_CaM_minus_TR2_minus_Ca2*Ca-kb*CaM_slash_CaM_minus_Ca3

051729
type: LocalParameter
units: 284709
value: 9.0E-16

051727
type: LocalParameter
units: 284793
value: 3.2400162E-16

285414
type: SpeciesReference
stoichiometry: 1.0
species: 561175

285401
type: SpeciesReference
stoichiometry: 1.0
species: 560215

285388
type: SpeciesReference
stoichiometry: 1.0
species: 561155

566895
type: Reaction
kinetic law: 286169
product: 286157
reactant: 286145
reactant: 286133
notes: For now let us set this to the same Km (1e-7M) as site B. This gives kf/kb = .7e-7M * 1e6 / (6e5^2) : 1/(6e5^2) = 2e-13:2.77e-12 Smith et al have better values. They say that this is cooperative, so the consts are now kf/kb =8.3e-4
fast: false
reversible: true

286169
type: KineticLaw
local parameters: 051777
local parameters: 051775
notes: kf*PKA_slash_R2C2_minus_cAMP*AC_slash_cAMP-kb*PKA_slash_R2C2_minus_cAMP2

051777
type: LocalParameter
units: 284709
value: 2.97E-15

051775
type: LocalParameter
units: 284793
value: 4.86E-15

286157
type: SpeciesReference
stoichiometry: 1.0
species: 562515

286145
type: SpeciesReference
stoichiometry: 1.0
species: 563635

286133
type: SpeciesReference
stoichiometry: 1.0
species: 562495

569414
type: Reaction
kinetic law: 292427
product: 292414
reactant: 292401
reactant: 292388
fast: false
reversible: true

292427
type: KineticLaw
local parameters: 052176
local parameters: 052173
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx

052176
type: LocalParameter
units: 284709
value: 7.2E-16

052173
type: LocalParameter
units: 284793
value: 1.8106416E-16

292414
type: SpeciesReference
stoichiometry: 1.0
species: 562015

292401
type: SpeciesReference
stoichiometry: 1.0
species: 561675

292388
type: SpeciesReference
stoichiometry: 1.0
species: 564815

565755
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

572214
type: Reaction
kinetic law: 299399
product: 299387
reactant: 299375
reactant: 299363
fast: false
reversible: true

299399
type: KineticLaw
local parameters: 052637
local parameters: 052634
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx

052637
type: LocalParameter
units: 284709
value: 6.8E-18

052634
type: LocalParameter
units: 284793
value: 8.7498E-18

299387
type: SpeciesReference
stoichiometry: 1.0
species: 563975

299375
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299363
type: SpeciesReference
stoichiometry: 1.0
species: 565155

572894
type: Reaction
kinetic law: 301044
product: 301032
reactant: 301020
reactant: 301007
fast: false
reversible: true

301044
type: KineticLaw
local parameters: 052749
local parameters: 052746
notes: k1*AMPAR_memb_slash_A_B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx

052749
type: LocalParameter
units: 284709
value: 1.4E-17

052746
type: LocalParameter
units: 284793
value: 8.7498E-18

301032
type: SpeciesReference
stoichiometry: 1.0
species: 564315

301020
type: SpeciesReference
stoichiometry: 1.0
species: 563755

301007
type: SpeciesReference
stoichiometry: 1.0
species: 565000

560136
type: Compartment
constant: true
size: 1.0E-18
spatial dimensions: 3.0

565775
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 560175

571194
type: Reaction
kinetic law: 296925
product: 296913
product: 296901
reactant: 296889
fast: false
reversible: false

296925
type: KineticLaw
local parameters: 052471
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx

052471
type: LocalParameter
units: 284709
value: 5.4E-16

296913
type: SpeciesReference
stoichiometry: 1.0
species: 562655

296901
type: SpeciesReference
stoichiometry: 1.0
species: 565215

296889
type: SpeciesReference
stoichiometry: 1.0
species: 563155

571354
type: Reaction
kinetic law: 297314
product: 297301
product: 297288
reactant: 297276
fast: false
reversible: false

297314
type: KineticLaw
local parameters: 052498
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx

052498
type: LocalParameter
units: 284709
value: 5.4E-16

297301
type: SpeciesReference
stoichiometry: 1.0
species: 562655

297288
type: SpeciesReference
stoichiometry: 1.0
species: 565235

297276
type: SpeciesReference
stoichiometry: 1.0
species: 563235

572234
type: Reaction
kinetic law: 299447
product: 299435
product: 299423
reactant: 299411
fast: false
reversible: false

299447
type: KineticLaw
local parameters: 052638
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx

052638
type: LocalParameter
units: 284709
value: 1.7E-18

299435
type: SpeciesReference
stoichiometry: 1.0
species: 563755

299423
type: SpeciesReference
stoichiometry: 1.0
species: 564995

299411
type: SpeciesReference
stoichiometry: 1.0
species: 563975

568895
type: Reaction
kinetic law: 290872
product: 290860
reactant: 290848
reactant: 290836
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true

290872
type: KineticLaw
local parameters: 052076
local parameters: 052073
notes: k1*CaM_slash_neurogranin_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx

052076
type: LocalParameter
units: 284709
value: 2.403E-16

052073
type: LocalParameter
units: 284793
value: 3.0024108E-17

290860
type: SpeciesReference
stoichiometry: 1.0
species: 561695

290848
type: SpeciesReference
stoichiometry: 1.0
species: 561675

290836
type: SpeciesReference
stoichiometry: 1.0
species: 561035

566775
type: Reaction
kinetic law: 285877
product: 285864
reactant: 285851
reactant: 285839
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true

285877
type: KineticLaw
local parameters: 051759
local parameters: 051757
notes: kf*PP1_slash_I1_star_*PP1_slash_PP1_minus_active-kb*PP1_slash_PP1_minus_I1_star_

051759
type: LocalParameter
units: 284709
value: 9.0E-18

051757
type: LocalParameter
units: 284793
value: 4.4998254E-14

285864
type: SpeciesReference
stoichiometry: 1.0
species: 561315

285851
type: SpeciesReference
stoichiometry: 1.0
species: 561455

285839
type: SpeciesReference
stoichiometry: 1.0
species: 561295

567215
type: Reaction
kinetic law: 286910
product: 286898
product: 286886
reactant: 286874
fast: false
reversible: true

286910
type: KineticLaw
local parameters: 051825
local parameters: 051823
notes: kf*AMPAR_memb_slash_A_B-kb*AMPAR_slash_A_B*AMPAR_memb_slash_Anchor

051825
type: LocalParameter
units: 284793
value: 0.0

051823
type: LocalParameter
units: 284709
value: 8.0E-21

286898
type: SpeciesReference
stoichiometry: 1.0
species: 565295

286886
type: SpeciesReference
stoichiometry: 1.0
species: 564655

286874
type: SpeciesReference
stoichiometry: 1.0
species: 564975