MODEL9086207764
type: SBMLModel
reaction: 409199
reaction: 412919
reaction: 407220
reaction: 410359
reaction: 410319
reaction: 410159
reaction: 408779
species: 401780
reaction: 409499
species: 405500
species: 404660
reaction: 410079
species: 403620
species: 404120
reaction: 407379
reaction: 409519
reaction: 410499
species: 406280
species: 402280
species: 403840
reaction: 411859
species: 403120
reaction: 411899
reaction: 411139
species: 405900
reaction: 413279
species: 401900
reaction: 411699
species: 404140
reaction: 409859
reaction: 412299
reaction: 407739
reaction: 408099
reaction: 409919
reaction: 412599
species: 404420
reaction: 408479
reaction: 409679
species: 403780
species: 400740
species: 403700
reaction: 413639
reaction: 408399
reaction: 407559
species: 405620
species: 406140
species: 405840
reaction: 407899
species: 405320
reaction: 408879
species: 401320
reaction: 411299
reaction: 411919
reaction: 407240
species: 405640
reaction: 409299
reaction: 410719
species: 401540
reaction: 410179
species: 404580
reaction: 408799
reaction: 407200
species: 405340
reaction: 408599
reaction: 410519
species: 401340
reaction: 410559
species: 405480
species: 401480
reaction: 407399
species: 405000
species: 401000
reaction: 410859
species: 402120
species: 405280
reaction: 410899
reaction: 412399
species: 401280
species: 404900

409199
type: Reaction
kinetic law: 264254
product: 264242
reactant: 264229
reactant: 264217
fast: false
reversible: true

264254
type: KineticLaw
local parameters: 207688
local parameters: 207686
notes: k1*AMPAR_slash_A845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx

207688
type: LocalParameter
units: 257775
value: 7.2E-16

257799
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

257787
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

207686
type: LocalParameter
units: 257862
value: 1.8106416E-16

257901
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

257888
type: SBMLUnit
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE

257875
type: SBMLUnit
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE

264242
type: SpeciesReference
stoichiometry: 1.0
species: 402320

402320
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

400680
type: Compartment
constant: true
size: 9.0E-17
spatial dimensions: 3.0

264229
type: SpeciesReference
stoichiometry: 1.0
species: 402200

402200
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

264217
type: SpeciesReference
stoichiometry: 1.0
species: 405220

405220
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

412919
type: Reaction
kinetic law: 273358
product: 273346
reactant: 273334
reactant: 273322
fast: false
reversible: true

273358
type: KineticLaw
local parameters: 208161
local parameters: 208159
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx

208161
type: LocalParameter
units: 257775
value: 6.8E-18

208159
type: LocalParameter
units: 257862
value: 8.7498E-18

273346
type: SpeciesReference
stoichiometry: 1.0
species: 404720

404720
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

400700
type: Compartment
constant: true
size: 1.0E-17
spatial dimensions: 3.0

273334
type: SpeciesReference
stoichiometry: 1.0
species: 404280

404280
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 400700

273322
type: SpeciesReference
stoichiometry: 1.0
species: 405800

405800
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

407220
type: Reaction
kinetic law: 258894
product: 258882
reactant: 258870
notes: Diffusional equilibrium between PSD- and cytosolic compartment. According to D. Bary in Cell Movements 2nd ed 2001 D for proteins is 5e-7 cm^2/s giving 10 ms for a translocation of 1 um.
fast: false
reversible: true

258894
type: KineticLaw
local parameters: 207394
local parameters: 207392
notes: kf*CaM_slash_CaM_minus_Ca4_minus_PSD-kb*CaM_slash_CaM_minus_Ca4

207394
type: LocalParameter
units: 257775
value: 5.4E-15

207392
type: LocalParameter
units: 257775
value: 5.4E-15

258882
type: SpeciesReference
stoichiometry: 1.0
species: 401780

401780
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

258870
type: SpeciesReference
stoichiometry: 1.0
species: 401720

401720
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

410359
type: Reaction
kinetic law: 267059
product: 267047
reactant: 267035
reactant: 267023
fast: false
reversible: true

267059
type: KineticLaw
local parameters: 207833
local parameters: 207831
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx

207833
type: LocalParameter
units: 257775
value: 7.2E-16

207831
type: LocalParameter
units: 257862
value: 2.011824E-17

267047
type: SpeciesReference
stoichiometry: 1.0
species: 402920

402920
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

267035
type: SpeciesReference
stoichiometry: 1.0
species: 402200

267023
type: SpeciesReference
stoichiometry: 1.0
species: 405800

410319
type: Reaction
kinetic law: 266963
product: 266951
reactant: 266939
reactant: 266926
fast: false
reversible: true

266963
type: KineticLaw
local parameters: 207828
local parameters: 207826
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx

207828
type: LocalParameter
units: 257775
value: 7.2E-16

207826
type: LocalParameter
units: 257862
value: 2.011824E-17

266951
type: SpeciesReference
stoichiometry: 1.0
species: 402900

402900
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

266939
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266926
type: SpeciesReference
stoichiometry: 1.0
species: 405800

410159
type: Reaction
kinetic law: 266575
product: 266563
reactant: 266551
reactant: 266539
fast: false
reversible: true

266575
type: KineticLaw
local parameters: 207808
local parameters: 207806
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx

207808
type: LocalParameter
units: 257775
value: 7.2E-16

207806
type: LocalParameter
units: 257862
value: 2.011824E-17

266563
type: SpeciesReference
stoichiometry: 1.0
species: 402820

402820
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

266551
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266539
type: SpeciesReference
stoichiometry: 1.0
species: 405780

405780
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

408779
type: Reaction
kinetic law: 263186
product: 263174
reactant: 263162
reactant: 263149
fast: false
reversible: true

263186
type: KineticLaw
local parameters: 207634
local parameters: 207632
notes: k1*CaMKII_slash_CaMKII_minus_thr286*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

207634
type: LocalParameter
units: 257775
value: 9.0E-16

207632
type: LocalParameter
units: 257862
value: 2.2062942E-16

263174
type: SpeciesReference
stoichiometry: 1.0
species: 402020

402020
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

263162
type: SpeciesReference
stoichiometry: 1.0
species: 401980

401980
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 400680

263149
type: SpeciesReference
stoichiometry: 1.0
species: 400840

400840
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

409499
type: Reaction
kinetic law: 264980
product: 264968
product: 264956
reactant: 264944
fast: false
reversible: false

264980
type: KineticLaw
local parameters: 207724
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx

207724
type: LocalParameter
units: 257775
value: 1.8E-16

264968
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264956
type: SpeciesReference
stoichiometry: 1.0
species: 405440

405440
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

264944
type: SpeciesReference
stoichiometry: 1.0
species: 402460

402460
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

405500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

404660
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

410079
type: Reaction
kinetic law: 266383
product: 266371
reactant: 266359
reactant: 266347
fast: false
reversible: true

266383
type: KineticLaw
local parameters: 207798
local parameters: 207796
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx

207798
type: LocalParameter
units: 257775
value: 7.2E-16

207796
type: LocalParameter
units: 257862
value: 2.011824E-17

266371
type: SpeciesReference
stoichiometry: 1.0
species: 402780

402780
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

266359
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266347
type: SpeciesReference
stoichiometry: 1.0
species: 405700

405700
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

403620
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

404120
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

407379
type: Reaction
kinetic law: 259561
product: 259549
reactant: 259537
notes: Random rate.
fast: false
reversible: true

259561
type: KineticLaw
local parameters: 207436
local parameters: 207434
notes: kf*AC_slash_AC2_star_-kb*AC_slash_AC2

207436
type: LocalParameter
units: 257775
value: 0.0

207434
type: LocalParameter
units: 257775
value: 9.0E-18

259549
type: SpeciesReference
stoichiometry: 1.0
species: 403940

403940
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 400680

259537
type: SpeciesReference
stoichiometry: 1.0
species: 403920

403920
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

409519
type: Reaction
kinetic law: 265028
product: 265016
reactant: 265004
reactant: 264992
fast: false
reversible: true

265028
type: KineticLaw
local parameters: 207728
local parameters: 207726
notes: k1*AMPAR_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx

207728
type: LocalParameter
units: 257775
value: 7.2E-16

207726
type: LocalParameter
units: 257862
value: 1.8106416E-16

265016
type: SpeciesReference
stoichiometry: 1.0
species: 402480

402480
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

265004
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264992
type: SpeciesReference
stoichiometry: 1.0
species: 405280

405280
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

410499
type: Reaction
kinetic law: 267396
product: 267384
product: 267372
reactant: 267360
fast: false
reversible: false

267396
type: KineticLaw
local parameters: 207849
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx

207849
type: LocalParameter
units: 257775
value: 6.03E-17

267384
type: SpeciesReference
stoichiometry: 1.0
species: 402200

267372
type: SpeciesReference
stoichiometry: 1.0
species: 401640

401640
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 400700

267360
type: SpeciesReference
stoichiometry: 1.0
species: 402980

402980
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

406280
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

402280
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

403840
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

411859
type: Reaction
kinetic law: 270788
product: 270776
product: 270764
reactant: 270752
fast: false
reversible: false

270788
type: KineticLaw
local parameters: 208024
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx

208024
type: LocalParameter
units: 257775
value: 5.4E-16

270776
type: SpeciesReference
stoichiometry: 1.0
species: 403180

403180
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

270764
type: SpeciesReference
stoichiometry: 1.0
species: 405620

405620
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

270752
type: SpeciesReference
stoichiometry: 1.0
species: 403880

403880
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

403120
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

411899
type: Reaction
kinetic law: 270885
modifier: 270873
product: 270861
reactant: 270849
notes: Reduced Km to match expt data for basal activation of AC2 by PKC. Now k1 = 2.9e-6, k2 = 72, k3 = 18 18 Feb: Raised Km to 300 based on BRENDA data. Unlikely to make much difference, given the vast amount of ATP.
fast: false
reversible: false

270885
type: KineticLaw
local parameters: 208031
local parameters: 208029
notes: kcat*AC_slash_AC2_star_*AC_slash_ATP/(Km+AC_slash_ATP)

208031
type: LocalParameter
units: 257739
value: 300.001920012288

257763
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

257751
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

208029
type: LocalParameter
units: 257775
value: 1.8E-16

270861
type: SpeciesReference
stoichiometry: 1.0
species: 404160

404160
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

270849
type: SpeciesReference
stoichiometry: 1.0
species: 405900

405900
type: Species
notes: ATP is present in all cells between 2 and 10 mM. See Lehninger
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2000.0
initial amount: NaN
in compartment: 400680

411139
type: Reaction
kinetic law: 269044
product: 269032
product: 269020
reactant: 269007
fast: false
reversible: false

269044
type: KineticLaw
local parameters: 207934
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx

207934
type: LocalParameter
units: 257775
value: 5.4E-16

269032
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269020
type: SpeciesReference
stoichiometry: 1.0
species: 405300

405300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

269007
type: SpeciesReference
stoichiometry: 1.0
species: 403520

403520
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

413279
type: Reaction
kinetic law: 274228
product: 274216
reactant: 274204
reactant: 274192
fast: false
reversible: true

274228
type: KineticLaw
local parameters: 208206
local parameters: 208204
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx

208206
type: LocalParameter
units: 257775
value: 1.4E-17

208204
type: LocalParameter
units: 257862
value: 8.7498E-18

274216
type: SpeciesReference
stoichiometry: 1.0
species: 404900

404900
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

274204
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274192
type: SpeciesReference
stoichiometry: 1.0
species: 405620

401900
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.99333333333333E-6
initial amount: NaN
in compartment: 400680

411699
type: Reaction
kinetic law: 270401
product: 270389
product: 270377
reactant: 270365
fast: false
reversible: false

270401
type: KineticLaw
local parameters: 208004
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx

208004
type: LocalParameter
units: 257775
value: 5.4E-16

270389
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270377
type: SpeciesReference
stoichiometry: 1.0
species: 405660

405660
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

270365
type: SpeciesReference
stoichiometry: 1.0
species: 403800

403800
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

404140
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400720

400720
type: Compartment
constant: true
size: 5.0E-15
spatial dimensions: 3.0

409859
type: Reaction
kinetic law: 265850
product: 265838
product: 265826
reactant: 265814
fast: false
reversible: false

265850
type: KineticLaw
local parameters: 207769
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx

207769
type: LocalParameter
units: 257775
value: 1.8E-16

265838
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265826
type: SpeciesReference
stoichiometry: 1.0
species: 405640

405640
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

265814
type: SpeciesReference
stoichiometry: 1.0
species: 402660

402660
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

412299
type: Reaction
kinetic law: 271852
product: 271840
product: 271828
reactant: 271816
fast: false
reversible: false

271852
type: KineticLaw
local parameters: 208080
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx

208080
type: LocalParameter
units: 257775
value: 1.7E-18

271840
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271828
type: SpeciesReference
stoichiometry: 1.0
species: 405580

405580
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

271816
type: SpeciesReference
stoichiometry: 1.0
species: 404400

404400
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

407739
type: Reaction
kinetic law: 260558
product: 260546
reactant: 260534
reactant: 260522
notes: See Hanson and Schulman again, for afterburst rates of phosph.
fast: false
reversible: true

260558
type: KineticLaw
local parameters: 207500
local parameters: 207498
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx

207500
type: LocalParameter
units: 257775
value: 2.16E-15

207498
type: LocalParameter
units: 257862
value: 1.5428556E-17

260546
type: SpeciesReference
stoichiometry: 1.0
species: 400900

400900
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.90055555555556E-8
initial amount: NaN
in compartment: 400680

260534
type: SpeciesReference
stoichiometry: 1.0
species: 406000

406000
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400680

260522
type: SpeciesReference
stoichiometry: 1.0
species: 400840

408099
type: Reaction
kinetic law: 261482
product: 261470
product: 261458
reactant: 261445
fast: false
reversible: false

261482
type: KineticLaw
local parameters: 207545
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx

207545
type: LocalParameter
units: 257775
value: 5.0E-18

261470
type: SpeciesReference
stoichiometry: 1.0
species: 406100

406100
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400700

261458
type: SpeciesReference
stoichiometry: 1.0
species: 405720

405720
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

261445
type: SpeciesReference
stoichiometry: 1.0
species: 401260

401260
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 400700

409919
type: Reaction
kinetic law: 265997
product: 265985
reactant: 265973
reactant: 265961
fast: false
reversible: true

265997
type: KineticLaw
local parameters: 207778
local parameters: 207776
notes: k1*AMPAR_memb_slash_A_B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx

207778
type: LocalParameter
units: 257775
value: 7.2E-16

207776
type: LocalParameter
units: 257862
value: 2.011824E-17

265985
type: SpeciesReference
stoichiometry: 1.0
species: 402700

402700
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

265973
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265961
type: SpeciesReference
stoichiometry: 1.0
species: 405640

412599
type: Reaction
kinetic law: 272588
product: 272576
reactant: 272564
reactant: 272552
fast: false
reversible: true

272588
type: KineticLaw
local parameters: 208120
local parameters: 208118
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx

208120
type: LocalParameter
units: 257775
value: 1.4E-17

208118
type: LocalParameter
units: 257862
value: 8.7498E-18

272576
type: SpeciesReference
stoichiometry: 1.0
species: 404560

404560
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

272564
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272552
type: SpeciesReference
stoichiometry: 1.0
species: 405700

404420
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

408479
type: Reaction
kinetic law: 262453
product: 262441
product: 262429
reactant: 262417
fast: false
reversible: false

262453
type: KineticLaw
local parameters: 207595
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx

207595
type: LocalParameter
units: 257775
value: 5.0E-18

262441
type: SpeciesReference
stoichiometry: 1.0
species: 406100

262429
type: SpeciesReference
stoichiometry: 1.0
species: 405560

405560
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

262417
type: SpeciesReference
stoichiometry: 1.0
species: 401460

401460
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 400700

409679
type: Reaction
kinetic law: 265415
product: 265403
reactant: 265391
reactant: 265378
fast: false
reversible: true

265415
type: KineticLaw
local parameters: 207748
local parameters: 207746
notes: k1*AMPAR_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx

207748
type: LocalParameter
units: 257775
value: 7.2E-16

207746
type: LocalParameter
units: 257862
value: 1.8106416E-16

265403
type: SpeciesReference
stoichiometry: 1.0
species: 402560

402560
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

265391
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265378
type: SpeciesReference
stoichiometry: 1.0
species: 405280

403780
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

400740
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 400680

403700
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

413639
type: Reaction
kinetic law: 275110
product: 275098
reactant: 275086
reactant: 275074
notes: Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4
fast: false
reversible: true

275110
type: KineticLaw
local parameters: 208251
local parameters: 208249
notes: k1*AC_slash_AC2*PKC_minus_active-k2*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx

208251
type: LocalParameter
units: 257775
value: 1.44E-15

208249
type: LocalParameter
units: 257862
value: 5.399946E-17

275098
type: SpeciesReference
stoichiometry: 1.0
species: 405100

405100
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.00703703703704E-5
initial amount: NaN
in compartment: 400680

275086
type: SpeciesReference
stoichiometry: 1.0
species: 405040

405040
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 400680

275074
type: SpeciesReference
stoichiometry: 1.0
species: 403940

408399
type: Reaction
kinetic law: 262211
product: 262199
reactant: 262187
reactant: 262175
fast: false
reversible: true

262211
type: KineticLaw
local parameters: 207584
local parameters: 207582
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx

207584
type: LocalParameter
units: 257775
value: 2.0E-17

207582
type: LocalParameter
units: 257862
value: 2.77776E-19

262199
type: SpeciesReference
stoichiometry: 1.0
species: 401420

401420
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 400700

262187
type: SpeciesReference
stoichiometry: 1.0
species: 406100

262175
type: SpeciesReference
stoichiometry: 1.0
species: 405700

407559
type: Reaction
kinetic law: 260168
product: 260156
reactant: 260144
reactant: 260131
notes: Exo rates are scaled from earlier model versions to account for binding of anchor. We have about 200 molecules of anchor in the whole model. Here we select rates to give us a max of about 150 molecules of GluR at the synapse.
fast: false
reversible: true

260168
type: KineticLaw
local parameters: 207475
local parameters: 207473
notes: kf*AMPAR_slash_A845_star__B845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A845_star__B845_star_

207475
type: LocalParameter
units: 257775
value: 8.0E-20

207473
type: LocalParameter
units: 257862
value: 1.08E-19

260156
type: SpeciesReference
stoichiometry: 1.0
species: 405680

405680
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

260144
type: SpeciesReference
stoichiometry: 1.0
species: 405840

405840
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 27.3333333333333
initial amount: NaN
in compartment: 400700

260131
type: SpeciesReference
stoichiometry: 1.0
species: 405280

406140
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

407899
type: Reaction
kinetic law: 260947
product: 260935
reactant: 260923
reactant: 260911
fast: false
reversible: true

260947
type: KineticLaw
local parameters: 207519
local parameters: 207517
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx

207519
type: LocalParameter
units: 257775
value: 2.0E-17

207517
type: LocalParameter
units: 257862
value: 2.77776E-19

260935
type: SpeciesReference
stoichiometry: 1.0
species: 401160

401160
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 400700

260923
type: SpeciesReference
stoichiometry: 1.0
species: 406100

260911
type: SpeciesReference
stoichiometry: 1.0
species: 405680

405320
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

408879
type: Reaction
kinetic law: 263430
product: 263418
product: 263405
reactant: 263393
fast: false
reversible: false

263430
type: KineticLaw
local parameters: 207645
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

207645
type: LocalParameter
units: 257775
value: 2.25E-16

263418
type: SpeciesReference
stoichiometry: 1.0
species: 401980

263405
type: SpeciesReference
stoichiometry: 1.0
species: 400940

400940
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

263393
type: SpeciesReference
stoichiometry: 1.0
species: 402060

402060
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

401320
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 400700

411299
type: Reaction
kinetic law: 269436
product: 269423
product: 269411
reactant: 269399
fast: false
reversible: false

269436
type: KineticLaw
local parameters: 207954
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx

207954
type: LocalParameter
units: 257775
value: 5.4E-16

269423
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269411
type: SpeciesReference
stoichiometry: 1.0
species: 405680

269399
type: SpeciesReference
stoichiometry: 1.0
species: 403600

403600
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

411919
type: Reaction
kinetic law: 270933
product: 270921
reactant: 270909
reactant: 270897
notes: Best rates are from Conti et al Biochem 34 7979-7987 1995. Though these are for the Sertoli cell form, it looks like they carry nicely into alternatively spliced brain form. See Sette et al JBC 269:28 18271-18274 Km ~2 uM, Vmax est ~ 10 umol/min/mg for pure form. Brain protein is 93 kD but this was 67. So k3 ~10, k2 ~40, k1 ~4.2e-6
fast: false
reversible: true

270933
type: KineticLaw
local parameters: 208034
local parameters: 208032
notes: k1*AC_slash_cAMP*AC_slash_cAMP_minus_PDE-k2*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx

208034
type: LocalParameter
units: 257775
value: 3.6E-15

208032
type: LocalParameter
units: 257862
value: 2.2680162E-16

270921
type: SpeciesReference
stoichiometry: 1.0
species: 404000

404000
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

270909
type: SpeciesReference
stoichiometry: 1.0
species: 403980

403980
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.555555555555556
initial amount: NaN
in compartment: 400680

270897
type: SpeciesReference
stoichiometry: 1.0
species: 404160

407240
type: Reaction
kinetic law: 258943
product: 258930
reactant: 258918
reactant: 258906
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true

258943
type: KineticLaw
local parameters: 207397
local parameters: 207395
notes: kf*PP1_slash_I1_star_*PP1_slash_PP1_minus_active-kb*PP1_slash_PP1_minus_I1_star_

207397
type: LocalParameter
units: 257775
value: 9.0E-18

207395
type: LocalParameter
units: 257862
value: 4.4998254E-14

258930
type: SpeciesReference
stoichiometry: 1.0
species: 401840

401840
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

258918
type: SpeciesReference
stoichiometry: 1.0
species: 401980

258906
type: SpeciesReference
stoichiometry: 1.0
species: 401820

401820
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

409299
type: Reaction
kinetic law: 264498
product: 264486
product: 264474
reactant: 264462
fast: false
reversible: false

264498
type: KineticLaw
local parameters: 207699
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx

207699
type: LocalParameter
units: 257775
value: 1.8E-16

264486
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264474
type: SpeciesReference
stoichiometry: 1.0
species: 405400

405400
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

264462
type: SpeciesReference
stoichiometry: 1.0
species: 402360

402360
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

410719
type: Reaction
kinetic law: 267984
product: 267972
product: 267960
reactant: 267948
fast: false
reversible: false

267984
type: KineticLaw
local parameters: 207879
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx

207879
type: LocalParameter
units: 257775
value: 5.4E-16

267972
type: SpeciesReference
stoichiometry: 1.0
species: 403180

267960
type: SpeciesReference
stoichiometry: 1.0
species: 405420

405420
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

267948
type: SpeciesReference
stoichiometry: 1.0
species: 403300

403300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

401540
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

410179
type: Reaction
kinetic law: 266623
product: 266611
product: 266599
reactant: 266587
fast: false
reversible: false

266623
type: KineticLaw
local parameters: 207809
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_8_sbc__slash_PP2B_sbo_8_sbc__cplx

207809
type: LocalParameter
units: 257775
value: 1.8E-16

266611
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266599
type: SpeciesReference
stoichiometry: 1.0
species: 405720

266587
type: SpeciesReference
stoichiometry: 1.0
species: 402820

404580
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

408799
type: Reaction
kinetic law: 263235
product: 263222
product: 263210
reactant: 263198
fast: false
reversible: false

263235
type: KineticLaw
local parameters: 207635
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

207635
type: LocalParameter
units: 257775
value: 2.25E-16

263222
type: SpeciesReference
stoichiometry: 1.0
species: 401980

263210
type: SpeciesReference
stoichiometry: 1.0
species: 400760

400760
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 20.0
initial amount: NaN
in compartment: 400680

263198
type: SpeciesReference
stoichiometry: 1.0
species: 402020

407200
type: Reaction
kinetic law: 258858
product: 258845
reactant: 258833
reactant: 258821
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true

258858
type: KineticLaw
local parameters: 207391
local parameters: 207389
notes: kf*CaM_slash_CaM_minus_Ca3*Ca-kb*CaM_slash_CaM_minus_Ca4

207391
type: LocalParameter
units: 257775
value: 9.0E-16

207389
type: LocalParameter
units: 257862
value: 4.1849946E-17

258845
type: SpeciesReference
stoichiometry: 1.0
species: 401780

258833
type: SpeciesReference
stoichiometry: 1.0
species: 400740

258821
type: SpeciesReference
stoichiometry: 1.0
species: 401700

401700
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

405340
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

408599
type: Reaction
kinetic law: 262752
product: 262740
product: 262728
reactant: 262716
fast: false
reversible: false

262752
type: KineticLaw
local parameters: 207610
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx

207610
type: LocalParameter
units: 257775
value: 1.8E-16

262740
type: SpeciesReference
stoichiometry: 1.0
species: 401880

401880
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.111111111111111
initial amount: NaN
in compartment: 400680

262728
type: SpeciesReference
stoichiometry: 1.0
species: 401800

401800
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.8
initial amount: NaN
in compartment: 400680

262716
type: SpeciesReference
stoichiometry: 1.0
species: 401900

410519
type: Reaction
kinetic law: 267444
product: 267432
reactant: 267420
reactant: 267408
notes: Same rates as PKA-phosph-I1
fast: false
reversible: true

267444
type: KineticLaw
local parameters: 207853
local parameters: 207851
notes: k1*AC_slash_cAMP_minus_PDE*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx

207853
type: LocalParameter
units: 257775
value: 3.24E-15

207851
type: LocalParameter
units: 257862
value: 5.399946E-16

267432
type: SpeciesReference
stoichiometry: 1.0
species: 403200

403200
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

267420
type: SpeciesReference
stoichiometry: 1.0
species: 403180

267408
type: SpeciesReference
stoichiometry: 1.0
species: 403980

401340
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 400700

410559
type: Reaction
kinetic law: 267542
product: 267530
reactant: 267518
reactant: 267505
notes: #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
fast: false
reversible: true

267542
type: KineticLaw
local parameters: 207858
local parameters: 207856
notes: k1*PP1_slash_I1*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx

207858
type: LocalParameter
units: 257775
value: 3.24E-15

207856
type: LocalParameter
units: 257862
value: 5.399946E-16

267530
type: SpeciesReference
stoichiometry: 1.0
species: 403220

403220
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

267518
type: SpeciesReference
stoichiometry: 1.0
species: 403180

267505
type: SpeciesReference
stoichiometry: 1.0
species: 401800

405480
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

401480
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

407399
type: Reaction
kinetic law: 259648
product: 259636
reactant: 259624
reactant: 259612
notes: For olf epi PDE1, affinity is 7 nM. Assume same for brain. Reaction should be pretty fast. Assume kb = 5/sec. Then kf = 5 / (0.007 * 6e5) = 1.2e-3
fast: false
reversible: true

259648
type: KineticLaw
local parameters: 207442
local parameters: 207440
notes: kf*AC_slash_PDE1*CaM_slash_CaM_minus_Ca4-kb*AC_slash_CaM_dot_PDE1

207442
type: LocalParameter
units: 257775
value: 4.5E-16

207440
type: LocalParameter
units: 257862
value: 6.479838E-14

259636
type: SpeciesReference
stoichiometry: 1.0
species: 404100

404100
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

259624
type: SpeciesReference
stoichiometry: 1.0
species: 401780

259612
type: SpeciesReference
stoichiometry: 1.0
species: 404060

404060
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.59259259259259
initial amount: NaN
in compartment: 400680

405000
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

401000
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

410859
type: Reaction
kinetic law: 268321
product: 268309
reactant: 268297
reactant: 268285
fast: false
reversible: true

268321
type: KineticLaw
local parameters: 207898
local parameters: 207896
notes: k1*AMPAR_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx

207898
type: LocalParameter
units: 257775
value: 2.16E-15

207896
type: LocalParameter
units: 257862
value: 3.5998992E-16

268309
type: SpeciesReference
stoichiometry: 1.0
species: 403380

403380
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

268297
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268285
type: SpeciesReference
stoichiometry: 1.0
species: 405400

402120
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

410899
type: Reaction
kinetic law: 268417
product: 268405
reactant: 268393
reactant: 268382
fast: false
reversible: true

268417
type: KineticLaw
local parameters: 207903
local parameters: 207901
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx

207903
type: LocalParameter
units: 257775
value: 2.16E-15

207901
type: LocalParameter
units: 257862
value: 3.5998992E-16

268405
type: SpeciesReference
stoichiometry: 1.0
species: 403400

403400
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

268393
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268382
type: SpeciesReference
stoichiometry: 1.0
species: 405440

412399
type: Reaction
kinetic law: 272092
product: 272080
reactant: 272068
reactant: 272056
fast: false
reversible: true

272092
type: KineticLaw
local parameters: 208094
local parameters: 208092
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx

208094
type: LocalParameter
units: 257775
value: 6.8E-18

208092
type: LocalParameter
units: 257862
value: 8.7498E-18

272080
type: SpeciesReference
stoichiometry: 1.0
species: 404460

404460
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

272068
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272056
type: SpeciesReference
stoichiometry: 1.0
species: 405760

405760
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

401280
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 400700

408959
type: Reaction
kinetic law: 263673
product: 263661
reactant: 263649
reactant: 263637
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true

263673
type: KineticLaw
local parameters: 207658
local parameters: 207656
notes: k1*PP1_PSD_slash_I1_star_*PP2B_slash_CaNAB_minus_Ca4-k2*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx

207658
type: LocalParameter
units: 257775
value: 1.224E-17

207656
type: LocalParameter
units: 257862
value: 3.420036E-19

263661
type: SpeciesReference
stoichiometry: 1.0
species: 402180

402180
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

263649
type: SpeciesReference
stoichiometry: 1.0
species: 402140

402140
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

263637
type: SpeciesReference
stoichiometry: 1.0
species: 404220

404220
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

401400
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.06666666666667E-215
initial amount: NaN
in compartment: 400700

413299
type: Reaction
kinetic law: 274276
product: 274264
product: 274252
reactant: 274240
fast: false
reversible: false

274276
type: KineticLaw
local parameters: 208207
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_26_sbc__slash_PP1_sbo_26_sbc__cplx

208207
type: LocalParameter
units: 257775
value: 3.5E-18

274264
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274252
type: SpeciesReference
stoichiometry: 1.0
species: 405660

274240
type: SpeciesReference
stoichiometry: 1.0
species: 404900

408019
type: Reaction
kinetic law: 261238
product: 261226
reactant: 261214
reactant: 261202
fast: false
reversible: true

261238
type: KineticLaw
local parameters: 207534
local parameters: 207532
notes: k1*AMPAR_memb_slash_A_B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx

207534
type: LocalParameter
units: 257775
value: 2.0E-17

207532
type: LocalParameter
units: 257862
value: 2.77776E-19

261226
type: SpeciesReference
stoichiometry: 1.0
species: 401220

401220
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 400700

261214
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261202
type: SpeciesReference
stoichiometry: 1.0
species: 405500

407759
type: Reaction
kinetic law: 260607
product: 260595
product: 260582
reactant: 260570
fast: false
reversible: false

260607
type: KineticLaw
local parameters: 207501
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_305_slash_auton_305_cplx

207501
type: LocalParameter
units: 257775
value: 5.4E-16

260595
type: SpeciesReference
stoichiometry: 1.0
species: 406000

260582
type: SpeciesReference
stoichiometry: 1.0
species: 400820

400820
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

260570
type: SpeciesReference
stoichiometry: 1.0
species: 400900

402840
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

413099
type: Reaction
kinetic law: 273794
product: 273782
product: 273769
reactant: 273756
fast: false
reversible: false

273794
type: KineticLaw
local parameters: 208182
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx

208182
type: LocalParameter
units: 257775
value: 3.5E-18

273782
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273769
type: SpeciesReference
stoichiometry: 1.0
species: 405680

273756
type: SpeciesReference
stoichiometry: 1.0
species: 404800

404800
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

408499
type: Reaction
kinetic law: 262501
product: 262489
reactant: 262477
reactant: 262465
fast: false
reversible: true

262501
type: KineticLaw
local parameters: 207599
local parameters: 207597
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD-k2*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx

207599
type: LocalParameter
units: 257775
value: 2.4E-16

207597
type: LocalParameter
units: 257862
value: 3.69594E-18

262489
type: SpeciesReference
stoichiometry: 1.0
species: 401480

262477
type: SpeciesReference
stoichiometry: 1.0
species: 406120

406120
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

262465
type: SpeciesReference
stoichiometry: 1.0
species: 401040

401040
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

407419
type: Reaction
kinetic law: 259684
product: 259672
reactant: 259660
notes: Represents diffusion, from a volume of 9e-20 to 5e-18. Assuming neck dimensions of 0.1 x 0.1 microns, this works out to a diffusion const of about 270 um^2/sec, which is pretty conservative. It is what cAMP does in frog cilia.
fast: false
reversible: true

259684
type: KineticLaw
local parameters: 207445
local parameters: 207443
notes: kf*AC_slash_cAMP-kb*AC_slash_cAMP_in_dend

207445
type: LocalParameter
units: 257775
value: 2.7E-14

207443
type: LocalParameter
units: 257775
value: 2.7E-14

259672
type: SpeciesReference
stoichiometry: 1.0
species: 404140

259660
type: SpeciesReference
stoichiometry: 1.0
species: 404160

401660
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

412699
type: Reaction
kinetic law: 272830
product: 272818
product: 272806
reactant: 272794
fast: false
reversible: false

272830
type: KineticLaw
local parameters: 208131
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx

208131
type: LocalParameter
units: 257775
value: 3.5E-18

272818
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272806
type: SpeciesReference
stoichiometry: 1.0
species: 405500

272794
type: SpeciesReference
stoichiometry: 1.0
species: 404600

404600
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

402080
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

413659
type: Reaction
kinetic law: 275158
product: 275146
product: 275134
reactant: 275122
fast: false
reversible: false

275158
type: KineticLaw
local parameters: 208252
notes: k3*PKC_minus_active_slash_phosph_minus_AC2_slash_phosph_minus_AC2_cplx

208252
type: LocalParameter
units: 257775
value: 3.6E-16

275146
type: SpeciesReference
stoichiometry: 1.0
species: 405040

275134
type: SpeciesReference
stoichiometry: 1.0
species: 403920

275122
type: SpeciesReference
stoichiometry: 1.0
species: 405100

407579
type: Reaction
kinetic law: 260204
product: 260192
reactant: 260180
fast: false
reversible: true

260204
type: KineticLaw
local parameters: 207478
local parameters: 207476
notes: kf*AMPAR_memb_slash_GluR23_M-kb*AMPAR_slash_GluR23_I

207478
type: LocalParameter
units: 257775
value: 1.26E-19

207476
type: LocalParameter
units: 257775
value: 3.5E-21

260192
type: SpeciesReference
stoichiometry: 1.0
species: 405160

405160
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0925925925925926
initial amount: NaN
in compartment: 400680

260180
type: SpeciesReference
stoichiometry: 1.0
species: 405820

405820
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.5
initial amount: NaN
in compartment: 400700

413619
type: Reaction
kinetic law: 275062
product: 275050
product: 275038
product: 275026
reactant: 275014
fast: false
reversible: false

275062
type: KineticLaw
local parameters: 208247
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx

208247
type: LocalParameter
units: 257775
value: 3.15E-17

275050
type: SpeciesReference
stoichiometry: 1.0
species: 405040

275038
type: SpeciesReference
stoichiometry: 1.0
species: 401560

401560
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

275026
type: SpeciesReference
stoichiometry: 1.0
species: 401520

401520
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 400680

275014
type: SpeciesReference
stoichiometry: 1.0
species: 405080

405080
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

403340
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

413459
type: Reaction
kinetic law: 274663
product: 274651
product: 274639
reactant: 274627
fast: false
reversible: false

274663
type: KineticLaw
local parameters: 208227
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx

208227
type: LocalParameter
units: 257775
value: 3.5E-18

274651
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274639
type: SpeciesReference
stoichiometry: 1.0
species: 405600

405600
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

274627
type: SpeciesReference
stoichiometry: 1.0
species: 404980

404980
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

406300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

402300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

413319
type: Reaction
kinetic law: 274325
product: 274313
reactant: 274301
reactant: 274288
fast: false
reversible: true

274325
type: KineticLaw
local parameters: 208211
local parameters: 208209
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx

208211
type: LocalParameter
units: 257775
value: 1.4E-17

208209
type: LocalParameter
units: 257862
value: 8.7498E-18

274313
type: SpeciesReference
stoichiometry: 1.0
species: 404920

404920
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

274301
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274288
type: SpeciesReference
stoichiometry: 1.0
species: 405560

411120
type: Reaction
kinetic law: 268995
product: 268983
reactant: 268971
reactant: 268959
fast: false
reversible: true

268995
type: KineticLaw
local parameters: 207933
local parameters: 207931
notes: k1*AMPAR_slash_A831_star_845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_29_sbc__slash_PKA_sbo_29_sbc__cplx

207933
type: LocalParameter
units: 257775
value: 2.16E-15

207931
type: LocalParameter
units: 257862
value: 3.5998992E-16

268983
type: SpeciesReference
stoichiometry: 1.0
species: 403520

268971
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268959
type: SpeciesReference
stoichiometry: 1.0
species: 405240

405240
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

401680
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

409399
type: Reaction
kinetic law: 264740
product: 264728
reactant: 264716
reactant: 264704
fast: false
reversible: true

264740
type: KineticLaw
local parameters: 207713
local parameters: 207711
notes: k1*AMPAR_slash_A831_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx

207713
type: LocalParameter
units: 257775
value: 7.2E-16

207711
type: LocalParameter
units: 257862
value: 1.8106416E-16

264728
type: SpeciesReference
stoichiometry: 1.0
species: 402420

402420
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

264716
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264704
type: SpeciesReference
stoichiometry: 1.0
species: 405480

402520
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

403280
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

404840
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

409359
type: Reaction
kinetic law: 264644
product: 264632
reactant: 264620
reactant: 264608
fast: false
reversible: true

264644
type: KineticLaw
local parameters: 207708
local parameters: 207706
notes: k1*AMPAR_slash_A_B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx

207708
type: LocalParameter
units: 257775
value: 7.2E-16

207706
type: LocalParameter
units: 257862
value: 1.8106416E-16

264632
type: SpeciesReference
stoichiometry: 1.0
species: 402400

402400
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

264620
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264608
type: SpeciesReference
stoichiometry: 1.0
species: 405260

405260
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

408899
type: Reaction
kinetic law: 263480
product: 263467
reactant: 263455
reactant: 263443
fast: false
reversible: true

263480
type: KineticLaw
local parameters: 207648
local parameters: 207646
notes: k1*CaMKII_slash_CaMK_minus_thr305*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

207648
type: LocalParameter
units: 257775
value: 9.0E-16

207646
type: LocalParameter
units: 257862
value: 2.2062942E-16

263467
type: SpeciesReference
stoichiometry: 1.0
species: 402080

263455
type: SpeciesReference
stoichiometry: 1.0
species: 401980

263443
type: SpeciesReference
stoichiometry: 1.0
species: 400940

411939
type: Reaction
kinetic law: 270982
product: 270970
product: 270957
reactant: 270945
fast: false
reversible: false

270982
type: KineticLaw
local parameters: 208035
notes: k3*AC_slash_cAMP_minus_PDE_slash_PDE_slash_PDE_cplx

208035
type: LocalParameter
units: 257775
value: 9.0E-16

270970
type: SpeciesReference
stoichiometry: 1.0
species: 403980

270957
type: SpeciesReference
stoichiometry: 1.0
species: 403960

403960
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

270945
type: SpeciesReference
stoichiometry: 1.0
species: 404000

406960
type: Reaction
kinetic law: 258218
product: 258206
reactant: 258193
reactant: 258181
notes: Same as for transloc_1
fast: false
reversible: true

258218
type: KineticLaw
local parameters: 207349
local parameters: 207347
notes: kf*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*CaMKII_slash_NMDAR-kb*CaMKII_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD

207349
type: LocalParameter
units: 257775
value: 0.0

207347
type: LocalParameter
units: 257862
value: 1.08E-20

258206
type: SpeciesReference
stoichiometry: 1.0
species: 401080

401080
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

258193
type: SpeciesReference
stoichiometry: 1.0
species: 401020

401020
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 120.0
initial amount: NaN
in compartment: 400700

258181
type: SpeciesReference
stoichiometry: 1.0
species: 400800

400800
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

404640
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

405140
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

408699
type: Reaction
kinetic law: 262993
product: 262981
reactant: 262969
reactant: 262956
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true

262993
type: KineticLaw
local parameters: 207624
local parameters: 207622
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx

207624
type: LocalParameter
units: 257775
value: 7.50006E-16

207622
type: LocalParameter
units: 257862
value: 6.4584E-18

262981
type: SpeciesReference
stoichiometry: 1.0
species: 401960

401960
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00127907407407407
initial amount: NaN
in compartment: 400680

262969
type: SpeciesReference
stoichiometry: 1.0
species: 401880

262956
type: SpeciesReference
stoichiometry: 1.0
species: 404240

404240
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

409279
type: Reaction
kinetic law: 264450
product: 264437
reactant: 264425
reactant: 264413
fast: false
reversible: true

264450
type: KineticLaw
local parameters: 207698
local parameters: 207696
notes: k1*AMPAR_slash_A845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_19_sbc__slash_PP2B_sbo_19_sbc__cplx

207698
type: LocalParameter
units: 257775
value: 7.2E-16

207696
type: LocalParameter
units: 257862
value: 1.8106416E-16

264437
type: SpeciesReference
stoichiometry: 1.0
species: 402360

264425
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264413
type: SpeciesReference
stoichiometry: 1.0
species: 405420

401600
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 26.3333333333333
initial amount: NaN
in compartment: 400700

404860
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

403100
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

406260
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

402260
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

410579
type: Reaction
kinetic law: 267595
product: 267581
product: 267568
reactant: 267555
fast: false
reversible: false

267595
type: KineticLaw
local parameters: 207859
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_slash_PKA_minus_phosph_minus_I1_cplx

207859
type: LocalParameter
units: 257775
value: 8.1E-16

267581
type: SpeciesReference
stoichiometry: 1.0
species: 403180

267568
type: SpeciesReference
stoichiometry: 1.0
species: 401820

267555
type: SpeciesReference
stoichiometry: 1.0
species: 403220

410279
type: Reaction
kinetic law: 266866
product: 266854
reactant: 266842
reactant: 266830
fast: false
reversible: true

266866
type: KineticLaw
local parameters: 207823
local parameters: 207821
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx

207823
type: LocalParameter
units: 257775
value: 7.2E-16

207821
type: LocalParameter
units: 257862
value: 2.011824E-17

266854
type: SpeciesReference
stoichiometry: 1.0
species: 402880

402880
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

266842
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266830
type: SpeciesReference
stoichiometry: 1.0
species: 405660

409719
type: Reaction
kinetic law: 265511
product: 265499
reactant: 265487
reactant: 265475
fast: false
reversible: true

265511
type: KineticLaw
local parameters: 207753
local parameters: 207751
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx

207753
type: LocalParameter
units: 257775
value: 7.2E-16

207751
type: LocalParameter
units: 257862
value: 1.8106416E-16

265499
type: SpeciesReference
stoichiometry: 1.0
species: 402580

402580
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

265487
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265475
type: SpeciesReference
stoichiometry: 1.0
species: 405300

410539
type: Reaction
kinetic law: 267492
product: 267480
product: 267468
reactant: 267456
fast: false
reversible: false

267492
type: KineticLaw
local parameters: 207854
notes: k3*PKA_slash_PKA_minus_active_slash_phosph_minus_PDE_slash_phosph_minus_PDE_cplx

207854
type: LocalParameter
units: 257775
value: 8.1E-16

267480
type: SpeciesReference
stoichiometry: 1.0
species: 403180

267468
type: SpeciesReference
stoichiometry: 1.0
species: 404020

404020
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

267456
type: SpeciesReference
stoichiometry: 1.0
species: 403200

410879
type: Reaction
kinetic law: 268369
product: 268357
product: 268345
reactant: 268333
fast: false
reversible: false

268369
type: KineticLaw
local parameters: 207899
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_22_sbc__slash_PKA_sbo_22_sbc__cplx

207899
type: LocalParameter
units: 257775
value: 5.4E-16

268357
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268345
type: SpeciesReference
stoichiometry: 1.0
species: 405360

405360
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

268333
type: SpeciesReference
stoichiometry: 1.0
species: 403380

400860
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6.3262962962963E-11
initial amount: NaN
in compartment: 400680

404300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

411339
type: Reaction
kinetic law: 269532
product: 269520
product: 269508
reactant: 269496
fast: false
reversible: false

269532
type: KineticLaw
local parameters: 207959
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx

207959
type: LocalParameter
units: 257775
value: 5.4E-16

269520
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269508
type: SpeciesReference
stoichiometry: 1.0
species: 405580

269496
type: SpeciesReference
stoichiometry: 1.0
species: 403620

411479
type: Reaction
kinetic law: 269870
product: 269858
reactant: 269846
reactant: 269834
fast: false
reversible: true

269870
type: KineticLaw
local parameters: 207978
local parameters: 207976
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx

207978
type: LocalParameter
units: 257775
value: 2.16E-15

207976
type: LocalParameter
units: 257862
value: 3.999888E-17

269858
type: SpeciesReference
stoichiometry: 1.0
species: 403700

269846
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269834
type: SpeciesReference
stoichiometry: 1.0
species: 405520

405520
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

410099
type: Reaction
kinetic law: 266431
product: 266419
product: 266407
reactant: 266395
fast: false
reversible: false

266431
type: KineticLaw
local parameters: 207799
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_6_sbc__slash_PP2B_sbo_6_sbc__cplx

207799
type: LocalParameter
units: 257775
value: 1.8E-16

266419
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266407
type: SpeciesReference
stoichiometry: 1.0
species: 405520

266395
type: SpeciesReference
stoichiometry: 1.0
species: 402780

404520
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

409539
type: Reaction
kinetic law: 265076
product: 265064
product: 265052
reactant: 265040
fast: false
reversible: false

265076
type: KineticLaw
local parameters: 207729
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_25_sbc__slash_PP2B_sbo_25_sbc__cplx

207729
type: LocalParameter
units: 257775
value: 1.8E-16

265064
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265052
type: SpeciesReference
stoichiometry: 1.0
species: 405260

265040
type: SpeciesReference
stoichiometry: 1.0
species: 402480

408979
type: Reaction
kinetic law: 263721
product: 263709
product: 263697
reactant: 263685
fast: false
reversible: false

263721
type: KineticLaw
local parameters: 207659
notes: k3*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_PSD_slash_dephosph_inhib1_noCaM_PSD_cplx

207659
type: LocalParameter
units: 257775
value: 3.06E-18

263709
type: SpeciesReference
stoichiometry: 1.0
species: 402140

263697
type: SpeciesReference
stoichiometry: 1.0
species: 404200

404200
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.0
initial amount: NaN
in compartment: 400700

263685
type: SpeciesReference
stoichiometry: 1.0
species: 402180

403680
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

404320
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

412799
type: Reaction
kinetic law: 273070
product: 273058
reactant: 273046
reactant: 273034
fast: false
reversible: true

273070
type: KineticLaw
local parameters: 208146
local parameters: 208143
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx

208146
type: LocalParameter
units: 257775
value: 6.8E-18

208143
type: LocalParameter
units: 257862
value: 8.7498E-18

273058
type: SpeciesReference
stoichiometry: 1.0
species: 404660

273046
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273034
type: SpeciesReference
stoichiometry: 1.0
species: 405720

409879
type: Reaction
kinetic law: 265900
product: 265887
reactant: 265875
reactant: 265863
fast: false
reversible: true

265900
type: KineticLaw
local parameters: 207773
local parameters: 207771
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx

207773
type: LocalParameter
units: 257775
value: 7.2E-16

207771
type: LocalParameter
units: 257862
value: 2.011824E-17

265887
type: SpeciesReference
stoichiometry: 1.0
species: 402680

402680
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

265875
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265863
type: SpeciesReference
stoichiometry: 1.0
species: 405680

407439
type: Reaction
kinetic law: 259780
product: 259768
reactant: 259756
reactant: 259744
notes: K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
fast: false
reversible: true

259780
type: KineticLaw
local parameters: 207451
local parameters: 207449
notes: kf*PP1_PSD_slash_I1_star_*PP1_PSD_slash_PP1_minus_active_PSD-kb*PP1_PSD_slash_PP1_minus_I1_star_

207451
type: LocalParameter
units: 257775
value: 1.0E-18

207449
type: LocalParameter
units: 257862
value: 4.9998E-15

259768
type: SpeciesReference
stoichiometry: 1.0
species: 404240

259756
type: SpeciesReference
stoichiometry: 1.0
species: 404280

259744
type: SpeciesReference
stoichiometry: 1.0
species: 404220

407040
type: Reaction
kinetic law: 258398
product: 258386
reactant: 258374
reactant: 258362
notes: Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
fast: false
reversible: true

258398
type: KineticLaw
local parameters: 207361
local parameters: 207359
notes: kf*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*CaM_slash_CaM_minus_Ca4_minus_PSD-kb*CaMKII_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD

207361
type: LocalParameter
units: 257775
value: 1.0E-18

207359
type: LocalParameter
units: 257862
value: 1.00002E-14

258386
type: SpeciesReference
stoichiometry: 1.0
species: 401080

258374
type: SpeciesReference
stoichiometry: 1.0
species: 401720

258362
type: SpeciesReference
stoichiometry: 1.0
species: 401040

412019
type: Reaction
kinetic law: 271177
product: 271165
product: 271152
reactant: 271140
fast: false
reversible: false

271177
type: KineticLaw
local parameters: 208045
notes: k3*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx

208045
type: LocalParameter
units: 257775
value: 1.5003E-16

271165
type: SpeciesReference
stoichiometry: 1.0
species: 404060

271152
type: SpeciesReference
stoichiometry: 1.0
species: 403960

271140
type: SpeciesReference
stoichiometry: 1.0
species: 404080

404080
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

413479
type: Reaction
kinetic law: 274711
product: 274699
reactant: 274687
reactant: 274675
fast: false
reversible: true

274711
type: KineticLaw
local parameters: 208231
local parameters: 208229
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx

208231
type: LocalParameter
units: 257775
value: 1.4E-17

208229
type: LocalParameter
units: 257862
value: 8.7498E-18

274699
type: SpeciesReference
stoichiometry: 1.0
species: 405000

274687
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274675
type: SpeciesReference
stoichiometry: 1.0
species: 405560

407259
type: Reaction
kinetic law: 258991
product: 258979
product: 258967
reactant: 258955
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true

258991
type: KineticLaw
local parameters: 207400
local parameters: 207398
notes: kf*PP1_slash_PP1_minus_I1-kb*PP1_slash_PP1_minus_active*PP1_slash_I1

207400
type: LocalParameter
units: 257862
value: 0.0

207398
type: LocalParameter
units: 257775
value: 9.0E-17

258979
type: SpeciesReference
stoichiometry: 1.0
species: 401800

258967
type: SpeciesReference
stoichiometry: 1.0
species: 401980

258955
type: SpeciesReference
stoichiometry: 1.0
species: 401860

401860
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

402940
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

404480
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

413139
type: Reaction
kinetic law: 273891
product: 273879
product: 273867
reactant: 273855
fast: false
reversible: false

273891
type: KineticLaw
local parameters: 208187
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx

208187
type: LocalParameter
units: 257775
value: 3.5E-18

273879
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273867
type: SpeciesReference
stoichiometry: 1.0
species: 405580

273855
type: SpeciesReference
stoichiometry: 1.0
species: 404820

404820
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

407100
type: Reaction
kinetic law: 258544
product: 258531
reactant: 258519
reactant: 258507
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true

258544
type: KineticLaw
local parameters: 207370
local parameters: 207368
notes: kf*CaM_slash_neurogranin*CaM_slash_CaM-kb*CaM_slash_neurogranin_minus_CaM

207370
type: LocalParameter
units: 257775
value: 9.0E-17

207368
type: LocalParameter
units: 257862
value: 2.7000216E-17

258531
type: SpeciesReference
stoichiometry: 1.0
species: 401540

258519
type: SpeciesReference
stoichiometry: 1.0
species: 401520

258507
type: SpeciesReference
stoichiometry: 1.0
species: 401580

401580
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 400680

408940
type: Reaction
kinetic law: 263625
product: 263612
product: 263600
reactant: 263588
fast: false
reversible: false

263625
type: KineticLaw
local parameters: 207654
notes: k3*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx

207654
type: LocalParameter
units: 257775
value: 3.06E-18

263612
type: SpeciesReference
stoichiometry: 1.0
species: 402140

263600
type: SpeciesReference
stoichiometry: 1.0
species: 401800

263588
type: SpeciesReference
stoichiometry: 1.0
species: 402160

402160
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

409379
type: Reaction
kinetic law: 264692
product: 264680
product: 264668
reactant: 264656
fast: false
reversible: false

264692
type: KineticLaw
local parameters: 207709
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_21_sbc__slash_PP2B_sbo_21_sbc__cplx

207709
type: LocalParameter
units: 257775
value: 1.8E-16

264680
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264668
type: SpeciesReference
stoichiometry: 1.0
species: 405180

405180
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

264656
type: SpeciesReference
stoichiometry: 1.0
species: 402400

406980
type: Reaction
kinetic law: 258254
product: 258242
reactant: 258230
fast: false
reversible: true

258254
type: KineticLaw
local parameters: 207352
local parameters: 207350
notes: kf*CaMKII_slash_basal_CaMKII_PSD_control-kb*CaMKII_slash_basal_CaMKII_PSD

207352
type: LocalParameter
units: 257775
value: 1.0E-17

207350
type: LocalParameter
units: 257775
value: 1.0E-17

258242
type: SpeciesReference
stoichiometry: 1.0
species: 401140

401140
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400700

258230
type: SpeciesReference
stoichiometry: 1.0
species: 405880

405880
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400700

412939
type: Reaction
kinetic law: 273406
product: 273394
product: 273382
reactant: 273370
fast: false
reversible: false

273406
type: KineticLaw
local parameters: 208162
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_17_sbc__slash_PP1_sbo_17_sbc__cplx

208162
type: LocalParameter
units: 257775
value: 1.7E-18

273394
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273382
type: SpeciesReference
stoichiometry: 1.0
species: 405620

273370
type: SpeciesReference
stoichiometry: 1.0
species: 404720

412979
type: Reaction
kinetic law: 273502
product: 273490
product: 273478
reactant: 273466
fast: false
reversible: false

273502
type: KineticLaw
local parameters: 208167
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx

208167
type: LocalParameter
units: 257775
value: 1.7E-18

273490
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273478
type: SpeciesReference
stoichiometry: 1.0
species: 405560

273466
type: SpeciesReference
stoichiometry: 1.0
species: 404740

404740
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

410379
type: Reaction
kinetic law: 267107
product: 267095
product: 267083
reactant: 267071
fast: false
reversible: false

267107
type: KineticLaw
local parameters: 207834
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_13_sbc__slash_PP2B_sbo_13_sbc__cplx

207834
type: LocalParameter
units: 257775
value: 1.8E-16

267095
type: SpeciesReference
stoichiometry: 1.0
species: 402200

267083
type: SpeciesReference
stoichiometry: 1.0
species: 405620

267071
type: SpeciesReference
stoichiometry: 1.0
species: 402920

406020
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 22.0
initial amount: NaN
in compartment: 400680

410299
type: Reaction
kinetic law: 266914
product: 266902
product: 266890
reactant: 266878
fast: false
reversible: false

266914
type: KineticLaw
local parameters: 207824
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_11_sbc__slash_PP2B_sbo_11_sbc__cplx

207824
type: LocalParameter
units: 257775
value: 1.8E-16

266902
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266890
type: SpeciesReference
stoichiometry: 1.0
species: 405540

405540
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

266878
type: SpeciesReference
stoichiometry: 1.0
species: 402880

405980
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

411019
type: Reaction
kinetic law: 268706
product: 268694
reactant: 268682
reactant: 268670
fast: false
reversible: true

268706
type: KineticLaw
local parameters: 207918
local parameters: 207916
notes: k1*AMPAR_slash_A_B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx

207918
type: LocalParameter
units: 257775
value: 2.16E-15

207916
type: LocalParameter
units: 257862
value: 3.5998992E-16

268694
type: SpeciesReference
stoichiometry: 1.0
species: 403460

403460
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

268682
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268670
type: SpeciesReference
stoichiometry: 1.0
species: 405360

411439
type: Reaction
kinetic law: 269774
product: 269762
reactant: 269750
reactant: 269738
fast: false
reversible: true

269774
type: KineticLaw
local parameters: 207973
local parameters: 207971
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx

207973
type: LocalParameter
units: 257775
value: 2.16E-15

207971
type: LocalParameter
units: 257862
value: 3.999888E-17

269762
type: SpeciesReference
stoichiometry: 1.0
species: 403680

269750
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269738
type: SpeciesReference
stoichiometry: 1.0
species: 405600

410199
type: Reaction
kinetic law: 266671
product: 266659
reactant: 266647
reactant: 266635
fast: false
reversible: true

266671
type: KineticLaw
local parameters: 207813
local parameters: 207811
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx

207813
type: LocalParameter
units: 257775
value: 7.2E-16

207811
type: LocalParameter
units: 257862
value: 2.011824E-17

266659
type: SpeciesReference
stoichiometry: 1.0
species: 402840

266647
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266635
type: SpeciesReference
stoichiometry: 1.0
species: 405780

409739
type: Reaction
kinetic law: 265559
product: 265547
product: 265535
reactant: 265523
fast: false
reversible: false

265559
type: KineticLaw
local parameters: 207754
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_30_sbc__slash_PP2B_sbo_30_sbc__cplx

207754
type: LocalParameter
units: 257775
value: 1.8E-16

265547
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265535
type: SpeciesReference
stoichiometry: 1.0
species: 405240

265523
type: SpeciesReference
stoichiometry: 1.0
species: 402580

402740
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

411499
type: Reaction
kinetic law: 269918
product: 269906
product: 269894
reactant: 269882
fast: false
reversible: false

269918
type: KineticLaw
local parameters: 207979
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_6_sbc__slash_PKA_sbo_6_sbc__cplx

207979
type: LocalParameter
units: 257775
value: 5.4E-16

269906
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269894
type: SpeciesReference
stoichiometry: 1.0
species: 405700

269882
type: SpeciesReference
stoichiometry: 1.0
species: 403700

411359
type: Reaction
kinetic law: 269580
product: 269568
reactant: 269556
reactant: 269544
fast: false
reversible: true

269580
type: KineticLaw
local parameters: 207963
local parameters: 207961
notes: k1*AMPAR_memb_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx

207963
type: LocalParameter
units: 257775
value: 2.16E-15

207961
type: LocalParameter
units: 257862
value: 3.999888E-17

269568
type: SpeciesReference
stoichiometry: 1.0
species: 403640

403640
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

269556
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269544
type: SpeciesReference
stoichiometry: 1.0
species: 405500

411319
type: Reaction
kinetic law: 269484
product: 269472
reactant: 269460
reactant: 269448
fast: false
reversible: true

269484
type: KineticLaw
local parameters: 207958
local parameters: 207956
notes: k1*AMPAR_memb_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_2_sbc__slash_PKA_sbo_2_sbc__cplx

207958
type: LocalParameter
units: 257775
value: 2.16E-15

207956
type: LocalParameter
units: 257862
value: 3.999888E-17

269472
type: SpeciesReference
stoichiometry: 1.0
species: 403620

269460
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269448
type: SpeciesReference
stoichiometry: 1.0
species: 405500

411159
type: Reaction
kinetic law: 269093
product: 269081
reactant: 269069
reactant: 269056
fast: false
reversible: true

269093
type: KineticLaw
local parameters: 207938
local parameters: 207936
notes: k1*AMPAR_slash_A845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx

207938
type: LocalParameter
units: 257775
value: 2.16E-15

207936
type: LocalParameter
units: 257862
value: 3.5998992E-16

269081
type: SpeciesReference
stoichiometry: 1.0
species: 403540

403540
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

269069
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269056
type: SpeciesReference
stoichiometry: 1.0
species: 405420

404360
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

409559
type: Reaction
kinetic law: 265124
product: 265112
reactant: 265100
reactant: 265088
fast: false
reversible: true

265124
type: KineticLaw
local parameters: 207733
local parameters: 207731
notes: k1*AMPAR_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx

207733
type: LocalParameter
units: 257775
value: 7.2E-16

207731
type: LocalParameter
units: 257862
value: 1.8106416E-16

265112
type: SpeciesReference
stoichiometry: 1.0
species: 402500

402500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

265100
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265088
type: SpeciesReference
stoichiometry: 1.0
species: 405300

406200
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

412119
type: Reaction
kinetic law: 271417
product: 271405
reactant: 271393
reactant: 271381
fast: false
reversible: true

271417
type: KineticLaw
local parameters: 208059
local parameters: 208057
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

208059
type: LocalParameter
units: 257775
value: 1.0E-16

208057
type: LocalParameter
units: 257862
value: 6.2502E-17

271405
type: SpeciesReference
stoichiometry: 1.0
species: 404320

271393
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271381
type: SpeciesReference
stoichiometry: 1.0
species: 401040

409219
type: Reaction
kinetic law: 264303
product: 264291
product: 264278
reactant: 264266
fast: false
reversible: false

264303
type: KineticLaw
local parameters: 207689
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_17_sbc__slash_PP2B_sbo_17_sbc__cplx

207689
type: LocalParameter
units: 257775
value: 1.8E-16

264291
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264278
type: SpeciesReference
stoichiometry: 1.0
species: 405180

264266
type: SpeciesReference
stoichiometry: 1.0
species: 402320

403320
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

409939
type: Reaction
kinetic law: 266045
product: 266033
product: 266021
reactant: 266009
fast: false
reversible: false

266045
type: KineticLaw
local parameters: 207779
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_2_sbc__slash_PP2B_sbo_2_sbc__cplx

207779
type: LocalParameter
units: 257775
value: 1.8E-16

266033
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266021
type: SpeciesReference
stoichiometry: 1.0
species: 405500

266009
type: SpeciesReference
stoichiometry: 1.0
species: 402700

409899
type: Reaction
kinetic law: 265949
product: 265937
product: 265925
reactant: 265913
fast: false
reversible: false

265949
type: KineticLaw
local parameters: 207774
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_1_sbc__slash_PP2B_sbo_1_sbc__cplx

207774
type: LocalParameter
units: 257775
value: 1.8E-16

265937
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265925
type: SpeciesReference
stoichiometry: 1.0
species: 405580

265913
type: SpeciesReference
stoichiometry: 1.0
species: 402680

409699
type: Reaction
kinetic law: 265463
product: 265451
product: 265439
reactant: 265427
fast: false
reversible: false

265463
type: KineticLaw
local parameters: 207749
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_29_sbc__slash_PP2B_sbo_29_sbc__cplx

207749
type: LocalParameter
units: 257775
value: 1.8E-16

265451
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265439
type: SpeciesReference
stoichiometry: 1.0
species: 405220

265427
type: SpeciesReference
stoichiometry: 1.0
species: 402560

407180
type: Reaction
kinetic law: 258773
product: 258761
reactant: 258749
reactant: 258737
notes: Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987
fast: false
reversible: true

258773
type: KineticLaw
local parameters: 207385
local parameters: 207383
notes: kf*CaM_slash_neurogranin_PSD*CaM_slash_CaM_minus_PSD-kb*CaM_slash_neurogranin_minus_CaM_PSD

207385
type: LocalParameter
units: 257775
value: 1.0E-17

207383
type: LocalParameter
units: 257862
value: 3.0E-18

258761
type: SpeciesReference
stoichiometry: 1.0
species: 401620

401620
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

258749
type: SpeciesReference
stoichiometry: 1.0
species: 401600

258737
type: SpeciesReference
stoichiometry: 1.0
species: 401640

400960
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

407060
type: Reaction
kinetic law: 258447
product: 258435
reactant: 258423
reactant: 258410
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true

258447
type: KineticLaw
local parameters: 207364
local parameters: 207362
notes: kf*CaM_slash_CaM*Ca^2-kb*CaM_slash_CaM_minus_TR2_minus_Ca2

207364
type: LocalParameter
units: 257775
value: 6.48E-15

207362
type: LocalParameter
units: 257811
value: 6.47990604E-15

257848
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

257835
type: SBMLUnit
exponent: -2.0
scale: -6
multipler: 1.0
kind: MOLE

257823
type: SBMLUnit
exponent: 3.0
scale: 0
multipler: 1.0
kind: LITRE

258435
type: SpeciesReference
stoichiometry: 1.0
species: 401680

258423
type: SpeciesReference
stoichiometry: 2.0
species: 400740

258410
type: SpeciesReference
stoichiometry: 1.0
species: 401520

402600
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

407779
type: Reaction
kinetic law: 260655
product: 260643
reactant: 260631
reactant: 260619
fast: false
reversible: true

260655
type: KineticLaw
local parameters: 207505
local parameters: 207503
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_autonomous_CaMKII-k2*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx

207505
type: LocalParameter
units: 257775
value: 1.8E-16

207503
type: LocalParameter
units: 257862
value: 1.2857616E-18

260643
type: SpeciesReference
stoichiometry: 1.0
species: 400920

400920
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.89444444444444E-5
initial amount: NaN
in compartment: 400680

260631
type: SpeciesReference
stoichiometry: 1.0
species: 406000

260619
type: SpeciesReference
stoichiometry: 1.0
species: 400780

400780
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

406360
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

407120
type: Reaction
kinetic law: 258580
product: 258568
reactant: 258556
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true

258580
type: KineticLaw
local parameters: 207373
local parameters: 207371
notes: kf*CaM_slash_neurogranin_star_-kb*CaM_slash_neurogranin

207373
type: LocalParameter
units: 257775
value: 0.0

207371
type: LocalParameter
units: 257775
value: 4.5E-19

258568
type: SpeciesReference
stoichiometry: 1.0
species: 401580

258556
type: SpeciesReference
stoichiometry: 1.0
species: 401560

413159
type: Reaction
kinetic law: 273939
product: 273927
reactant: 273915
reactant: 273903
fast: false
reversible: true

273939
type: KineticLaw
local parameters: 208191
local parameters: 208189
notes: k1*AMPAR_memb_slash_A_B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx

208191
type: LocalParameter
units: 257775
value: 1.4E-17

208189
type: LocalParameter
units: 257862
value: 8.7498E-18

273927
type: SpeciesReference
stoichiometry: 1.0
species: 404840

273915
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273903
type: SpeciesReference
stoichiometry: 1.0
species: 405540

403480
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

403000
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: 400680

407460
type: Reaction
kinetic law: 259878
product: 259866
product: 259854
reactant: 259841
fast: false
reversible: true

259878
type: KineticLaw
local parameters: 207457
local parameters: 207455
notes: kf*AMPAR_memb_slash_A_B831_star_-kb*AMPAR_slash_A_B831_star_*AMPAR_memb_slash_Anchor

207457
type: LocalParameter
units: 257862
value: 0.0

207455
type: LocalParameter
units: 257775
value: 8.0E-21

259866
type: SpeciesReference
stoichiometry: 1.0
species: 405840

259854
type: SpeciesReference
stoichiometry: 1.0
species: 405400

259841
type: SpeciesReference
stoichiometry: 1.0
species: 405540

412819
type: Reaction
kinetic law: 273118
product: 273106
product: 273094
reactant: 273082
fast: false
reversible: false

273118
type: KineticLaw
local parameters: 208147
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_14_sbc__slash_PP1_sbo_14_sbc__cplx

208147
type: LocalParameter
units: 257775
value: 1.7E-18

273106
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273094
type: SpeciesReference
stoichiometry: 1.0
species: 405540

273082
type: SpeciesReference
stoichiometry: 1.0
species: 404660

410399
type: Reaction
kinetic law: 267155
product: 267143
reactant: 267131
reactant: 267119
fast: false
reversible: true

267155
type: KineticLaw
local parameters: 207838
local parameters: 207836
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx

207838
type: LocalParameter
units: 257775
value: 7.2E-16

207836
type: LocalParameter
units: 257862
value: 2.011824E-17

267143
type: SpeciesReference
stoichiometry: 1.0
species: 402940

267131
type: SpeciesReference
stoichiometry: 1.0
species: 402200

267119
type: SpeciesReference
stoichiometry: 1.0
species: 405620

412999
type: Reaction
kinetic law: 273550
product: 273538
reactant: 273526
reactant: 273514
fast: false
reversible: true

273550
type: KineticLaw
local parameters: 208171
local parameters: 208169
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx

208171
type: LocalParameter
units: 257775
value: 6.8E-18

208169
type: LocalParameter
units: 257862
value: 8.7498E-18

273538
type: SpeciesReference
stoichiometry: 1.0
species: 404760

404760
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

273526
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273514
type: SpeciesReference
stoichiometry: 1.0
species: 405620

407260
type: Reaction
kinetic law: 259040
product: 259028
reactant: 259016
reactant: 259004
notes: This process is probably much more complicated and involves CaM. However, as I can\'t find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11
fast: false
reversible: true

259040
type: KineticLaw
local parameters: 207403
local parameters: 207401
notes: kf*Ca^2*PP2B_slash_CaNAB_minus_Ca2-kb*PP2B_slash_CaNAB_minus_Ca4

207403
type: LocalParameter
units: 257775
value: 9.0E-17

207401
type: LocalParameter
units: 257811
value: 3.24008424E-16

259028
type: SpeciesReference
stoichiometry: 1.0
species: 402140

259016
type: SpeciesReference
stoichiometry: 1.0
species: 402120

259004
type: SpeciesReference
stoichiometry: 2.0
species: 400740

407420
type: Reaction
kinetic law: 259732
product: 259720
product: 259708
reactant: 259696
notes: Let us assume that the equil in this case is very far over to the right. This is probably safe.
fast: false
reversible: true

259732
type: KineticLaw
local parameters: 207448
local parameters: 207446
notes: kf*PP1_PSD_slash_PP1_minus_I1-kb*PP1_PSD_slash_I1*PP1_PSD_slash_PP1_minus_active_PSD

207448
type: LocalParameter
units: 257862
value: 0.0

207446
type: LocalParameter
units: 257775
value: 1.0E-17

259720
type: SpeciesReference
stoichiometry: 1.0
species: 404280

259708
type: SpeciesReference
stoichiometry: 1.0
species: 404200

259696
type: SpeciesReference
stoichiometry: 1.0
species: 404260

404260
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

412959
type: Reaction
kinetic law: 273454
product: 273442
reactant: 273430
reactant: 273418
fast: false
reversible: true

273454
type: KineticLaw
local parameters: 208166
local parameters: 208164
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_18_sbc__slash_PP1_sbo_18_sbc__cplx

208166
type: LocalParameter
units: 257775
value: 6.8E-18

208164
type: LocalParameter
units: 257862
value: 8.7498E-18

273442
type: SpeciesReference
stoichiometry: 1.0
species: 404740

273430
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273418
type: SpeciesReference
stoichiometry: 1.0
species: 405740

405740
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

410739
type: Reaction
kinetic law: 268032
product: 268020
reactant: 268008
reactant: 267996
fast: false
reversible: true

268032
type: KineticLaw
local parameters: 207883
local parameters: 207881
notes: k1*AMPAR_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx

207883
type: LocalParameter
units: 257775
value: 2.16E-15

207881
type: LocalParameter
units: 257862
value: 3.5998992E-16

268020
type: SpeciesReference
stoichiometry: 1.0
species: 403320

268008
type: SpeciesReference
stoichiometry: 1.0
species: 403180

267996
type: SpeciesReference
stoichiometry: 1.0
species: 405440

408119
type: Reaction
kinetic law: 261531
product: 261519
reactant: 261506
reactant: 261494
fast: false
reversible: true

261531
type: KineticLaw
local parameters: 207549
local parameters: 207547
notes: k1*AMPAR_memb_slash_A845_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx

207549
type: LocalParameter
units: 257775
value: 2.0E-17

207547
type: LocalParameter
units: 257862
value: 2.77776E-19

261519
type: SpeciesReference
stoichiometry: 1.0
species: 401280

261506
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261494
type: SpeciesReference
stoichiometry: 1.0
species: 405580

410779
type: Reaction
kinetic law: 268128
product: 268116
reactant: 268104
reactant: 268092
fast: false
reversible: true

268128
type: KineticLaw
local parameters: 207888
local parameters: 207886
notes: k1*AMPAR_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx

207888
type: LocalParameter
units: 257775
value: 2.16E-15

207886
type: LocalParameter
units: 257862
value: 3.5998992E-16

268116
type: SpeciesReference
stoichiometry: 1.0
species: 403340

268104
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268092
type: SpeciesReference
stoichiometry: 1.0
species: 405180

403720
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

412619
type: Reaction
kinetic law: 272636
product: 272624
product: 272612
reactant: 272600
fast: false
reversible: false

272636
type: KineticLaw
local parameters: 208121
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_9_sbc__slash_PP1_sbo_9_sbc__cplx

208121
type: LocalParameter
units: 257775
value: 3.5E-18

272624
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272612
type: SpeciesReference
stoichiometry: 1.0
species: 405640

272600
type: SpeciesReference
stoichiometry: 1.0
species: 404560

403860
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

411419
type: Reaction
kinetic law: 269726
product: 269714
product: 269702
reactant: 269690
fast: false
reversible: false

269726
type: KineticLaw
local parameters: 207969
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx

207969
type: LocalParameter
units: 257775
value: 5.4E-16

269714
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269702
type: SpeciesReference
stoichiometry: 1.0
species: 405760

269690
type: SpeciesReference
stoichiometry: 1.0
species: 403660

403660
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

404500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

409419
type: Reaction
kinetic law: 264788
product: 264776
product: 264764
reactant: 264752
fast: false
reversible: false

264788
type: KineticLaw
local parameters: 207714
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_22_sbc__slash_PP2B_sbo_22_sbc__cplx

207714
type: LocalParameter
units: 257775
value: 1.8E-16

264776
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264764
type: SpeciesReference
stoichiometry: 1.0
species: 405200

405200
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

264752
type: SpeciesReference
stoichiometry: 1.0
species: 402420

404180
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 400700

411179
type: Reaction
kinetic law: 269142
product: 269130
product: 269118
reactant: 269105
fast: false
reversible: false

269142
type: KineticLaw
local parameters: 207939
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_30_sbc__slash_PKA_sbo_30_sbc__cplx

207939
type: LocalParameter
units: 257775
value: 5.4E-16

269130
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269118
type: SpeciesReference
stoichiometry: 1.0
species: 405320

269105
type: SpeciesReference
stoichiometry: 1.0
species: 403540

400663
type: Compartment
constant: true
size: 1.0E-18
spatial dimensions: 3.0

408039
type: Reaction
kinetic law: 261286
product: 261274
product: 261262
reactant: 261250
fast: false
reversible: false

261286
type: KineticLaw
local parameters: 207535
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_3_sbc__slash_CaMKII_sbo_3_sbc__cplx

207535
type: LocalParameter
units: 257775
value: 5.0E-18

261274
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261262
type: SpeciesReference
stoichiometry: 1.0
species: 405520

261250
type: SpeciesReference
stoichiometry: 1.0
species: 401220

401940
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.21555555555556E-7
initial amount: NaN
in compartment: 400680

409239
type: Reaction
kinetic law: 264353
product: 264340
reactant: 264327
reactant: 264315
fast: false
reversible: true

264353
type: KineticLaw
local parameters: 207693
local parameters: 207691
notes: k1*AMPAR_slash_A831_star_845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx

207693
type: LocalParameter
units: 257775
value: 7.2E-16

207691
type: LocalParameter
units: 257862
value: 1.8106416E-16

264340
type: SpeciesReference
stoichiometry: 1.0
species: 402340

402340
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

264327
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264315
type: SpeciesReference
stoichiometry: 1.0
species: 405240

401200
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 400700

410919
type: Reaction
kinetic law: 268465
product: 268453
product: 268441
reactant: 268429
fast: false
reversible: false

268465
type: KineticLaw
local parameters: 207904
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_23_sbc__slash_PKA_sbo_23_sbc__cplx

207904
type: LocalParameter
units: 257775
value: 5.4E-16

268453
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268441
type: SpeciesReference
stoichiometry: 1.0
species: 405380

405380
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

268429
type: SpeciesReference
stoichiometry: 1.0
species: 403400

408999
type: Reaction
kinetic law: 263770
product: 263757
reactant: 263745
reactant: 263733
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true

263770
type: KineticLaw
local parameters: 207663
local parameters: 207661
notes: k1*CaM_slash_neurogranin_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx

207663
type: LocalParameter
units: 257775
value: 2.403E-16

207661
type: LocalParameter
units: 257862
value: 3.0024108E-17

263757
type: SpeciesReference
stoichiometry: 1.0
species: 402220

402220
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

263745
type: SpeciesReference
stoichiometry: 1.0
species: 402200

263733
type: SpeciesReference
stoichiometry: 1.0
species: 401560

410239
type: Reaction
kinetic law: 266769
product: 266757
reactant: 266745
reactant: 266732
fast: false
reversible: true

266769
type: KineticLaw
local parameters: 207818
local parameters: 207816
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx

207818
type: LocalParameter
units: 257775
value: 7.2E-16

207816
type: LocalParameter
units: 257862
value: 2.011824E-17

266757
type: SpeciesReference
stoichiometry: 1.0
species: 402860

402860
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

266745
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266732
type: SpeciesReference
stoichiometry: 1.0
species: 405720

409959
type: Reaction
kinetic law: 266093
product: 266081
reactant: 266069
reactant: 266057
fast: false
reversible: true

266093
type: KineticLaw
local parameters: 207783
local parameters: 207781
notes: k1*AMPAR_memb_slash_A845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx

207783
type: LocalParameter
units: 257775
value: 7.2E-16

207781
type: LocalParameter
units: 257862
value: 2.011824E-17

266081
type: SpeciesReference
stoichiometry: 1.0
species: 402720

402720
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

266069
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266057
type: SpeciesReference
stoichiometry: 1.0
species: 405580

412219
type: Reaction
kinetic law: 271659
product: 271647
product: 271634
reactant: 271622
fast: false
reversible: false

271659
type: KineticLaw
local parameters: 208070
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

208070
type: LocalParameter
units: 257775
value: 2.5E-17

271647
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271634
type: SpeciesReference
stoichiometry: 1.0
species: 400960

271622
type: SpeciesReference
stoichiometry: 1.0
species: 404360

407799
type: Reaction
kinetic law: 260703
product: 260691
product: 260679
reactant: 260667
fast: false
reversible: false

260703
type: KineticLaw
local parameters: 207506
notes: k3*CaMKII_slash_tot_autonomous_CaMKII_slash_auton_286_slash_auton_286_cplx

207506
type: LocalParameter
units: 257775
value: 4.5E-17

260691
type: SpeciesReference
stoichiometry: 1.0
species: 406000

260679
type: SpeciesReference
stoichiometry: 1.0
species: 400800

260667
type: SpeciesReference
stoichiometry: 1.0
species: 400920

413679
type: Reaction
kinetic law: 275206
product: 275194
reactant: 275182
reactant: 275170
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

275206
type: KineticLaw
local parameters: 208256
local parameters: 208254
notes: k1*CaM_slash_neurogranin_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx

208256
type: LocalParameter
units: 257775
value: 2.106E-16

208254
type: LocalParameter
units: 257862
value: 1.020006E-18

275194
type: SpeciesReference
stoichiometry: 1.0
species: 405120

405120
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

275182
type: SpeciesReference
stoichiometry: 1.0
species: 405040

275170
type: SpeciesReference
stoichiometry: 1.0
species: 401640

403040
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

407459
type: Reaction
kinetic law: 259829
product: 259817
product: 259804
reactant: 259792
fast: false
reversible: true

259829
type: KineticLaw
local parameters: 207454
local parameters: 207452
notes: kf*AMPAR_memb_slash_A831_star__B831_star_-kb*AMPAR_slash_A831_star__B831_star_*AMPAR_memb_slash_Anchor

207454
type: LocalParameter
units: 257862
value: 0.0

207452
type: LocalParameter
units: 257775
value: 8.0E-21

259817
type: SpeciesReference
stoichiometry: 1.0
species: 405840

259804
type: SpeciesReference
stoichiometry: 1.0
species: 405440

259792
type: SpeciesReference
stoichiometry: 1.0
species: 405560

407599
type: Reaction
kinetic law: 260241
product: 260228
reactant: 260216
fast: false
reversible: true

260241
type: KineticLaw
local parameters: 207481
local parameters: 207479
notes: kf*PKC_minus_control-kb*PKC_minus_active

207481
type: LocalParameter
units: 257775
value: 2.25E-16

207479
type: LocalParameter
units: 257775
value: 2.25E-16

260228
type: SpeciesReference
stoichiometry: 1.0
species: 405040

260216
type: SpeciesReference
stoichiometry: 1.0
species: 405920

405920
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 400680

406880
type: Reaction
kinetic law: 258024
product: 258012
reactant: 258000
reactant: 257988
notes: Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
fast: false
reversible: true

258024
type: KineticLaw
local parameters: 207337
local parameters: 207335
notes: kf*CaMKII_slash_CaMKII_minus_thr286*CaM_slash_CaM_minus_Ca4-kb*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM

207337
type: LocalParameter
units: 257775
value: 9.0E-18

207335
type: LocalParameter
units: 257862
value: 9.001692E-14

258012
type: SpeciesReference
stoichiometry: 1.0
species: 400800

258000
type: SpeciesReference
stoichiometry: 1.0
species: 401780

257988
type: SpeciesReference
stoichiometry: 1.0
species: 400840

406080
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400700

406180
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

402000
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

408319
type: Reaction
kinetic law: 262018
product: 262005
reactant: 261993
reactant: 261980
fast: false
reversible: true

262018
type: KineticLaw
local parameters: 207574
local parameters: 207572
notes: k1*AMPAR_memb_slash_A_B831_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx

207574
type: LocalParameter
units: 257775
value: 2.0E-17

207572
type: LocalParameter
units: 257862
value: 2.77776E-19

262005
type: SpeciesReference
stoichiometry: 1.0
species: 401380

401380
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.02566666666667E-215
initial amount: NaN
in compartment: 400700

261993
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261980
type: SpeciesReference
stoichiometry: 1.0
species: 405540

413499
type: Reaction
kinetic law: 274760
product: 274748
product: 274736
reactant: 274723
fast: false
reversible: false

274760
type: KineticLaw
local parameters: 208232
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_31_sbc__slash_PP1_sbo_31_sbc__cplx

208232
type: LocalParameter
units: 257775
value: 3.5E-18

274748
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274736
type: SpeciesReference
stoichiometry: 1.0
species: 405520

274723
type: SpeciesReference
stoichiometry: 1.0
species: 405000

408219
type: Reaction
kinetic law: 261773
product: 261761
product: 261749
reactant: 261737
fast: false
reversible: false

261773
type: KineticLaw
local parameters: 207560
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx

207560
type: LocalParameter
units: 257775
value: 5.0E-18

261761
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261749
type: SpeciesReference
stoichiometry: 1.0
species: 405800

261737
type: SpeciesReference
stoichiometry: 1.0
species: 401320

407819
type: Reaction
kinetic law: 260753
product: 260740
reactant: 260728
reactant: 260715
fast: false
reversible: true

260753
type: KineticLaw
local parameters: 207510
local parameters: 207508
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_PSD*CaMKII_slash_tot_minus_auto_minus_PSD-k2*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx

207510
type: LocalParameter
units: 257775
value: 2.4E-16

207508
type: LocalParameter
units: 257862
value: 2.4E-18

260740
type: SpeciesReference
stoichiometry: 1.0
species: 401100

401100
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

260728
type: SpeciesReference
stoichiometry: 1.0
species: 406060

406060
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400700

260715
type: SpeciesReference
stoichiometry: 1.0
species: 401040

401360
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 400700

411959
type: Reaction
kinetic law: 271031
product: 271019
reactant: 271006
reactant: 270994
notes: This form has about twice the activity of the unphosphorylated form. See Sette et al JBC 269:28 18271-18274 1994. We\'ll ignore cGMP effects for now.
fast: false
reversible: true

271031
type: KineticLaw
local parameters: 208039
local parameters: 208037
notes: k1*AC_slash_cAMP*AC_slash_cAMP_minus_PDE_star_-k2*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx

208039
type: LocalParameter
units: 257775
value: 7.2E-15

208037
type: LocalParameter
units: 257862
value: 4.5359838E-16

271019
type: SpeciesReference
stoichiometry: 1.0
species: 404040

404040
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

271006
type: SpeciesReference
stoichiometry: 1.0
species: 404020

270994
type: SpeciesReference
stoichiometry: 1.0
species: 404160

411999
type: Reaction
kinetic law: 271127
product: 271115
reactant: 271103
reactant: 271091
notes: Rate is 1/6 of the CaM stim form. We\'ll just reduce all lf k1, k2, k3 so that the Vmax goes down 1/6.
fast: false
reversible: true

271127
type: KineticLaw
local parameters: 208044
local parameters: 208042
notes: k1*AC_slash_cAMP*AC_slash_PDE1-k2*AC_slash_PDE1_slash_PDE1_slash_PDE1_cplx

208044
type: LocalParameter
units: 257775
value: 6.003E-16

208042
type: LocalParameter
units: 257862
value: 1.8900054E-17

271115
type: SpeciesReference
stoichiometry: 1.0
species: 404080

271103
type: SpeciesReference
stoichiometry: 1.0
species: 404060

271091
type: SpeciesReference
stoichiometry: 1.0
species: 404160

407280
type: Reaction
kinetic law: 259140
product: 259127
reactant: 259115
reactant: 259103
fast: false
reversible: true

259140
type: KineticLaw
local parameters: 207409
local parameters: 207407
notes: kf*CaM_slash_CaM_minus_Ca4*PP2B_slash_CaNAB_minus_Ca4-kb*PP2B_slash_CaM_Ca_n_minus_CaNAB

207409
type: LocalParameter
units: 257775
value: 9.0E-17

207407
type: LocalParameter
units: 257862
value: 5.399946E-14

259127
type: SpeciesReference
stoichiometry: 1.0
species: 402200

259115
type: SpeciesReference
stoichiometry: 1.0
species: 402140

259103
type: SpeciesReference
stoichiometry: 1.0
species: 401780

408139
type: Reaction
kinetic law: 261579
product: 261567
product: 261555
reactant: 261543
fast: false
reversible: false

261579
type: KineticLaw
local parameters: 207550
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_6_sbc__slash_CaMKII_sbo_6_sbc__cplx

207550
type: LocalParameter
units: 257775
value: 5.0E-18

261567
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261555
type: SpeciesReference
stoichiometry: 1.0
species: 405660

261543
type: SpeciesReference
stoichiometry: 1.0
species: 401280

410759
type: Reaction
kinetic law: 268080
product: 268068
product: 268056
reactant: 268044
fast: false
reversible: false

268080
type: KineticLaw
local parameters: 207884
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_19_sbc__slash_PKA_sbo_19_sbc__cplx

207884
type: LocalParameter
units: 257775
value: 5.4E-16

268068
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268056
type: SpeciesReference
stoichiometry: 1.0
species: 405460

405460
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

268044
type: SpeciesReference
stoichiometry: 1.0
species: 403320

410799
type: Reaction
kinetic law: 268176
product: 268164
product: 268152
reactant: 268140
fast: false
reversible: false

268176
type: KineticLaw
local parameters: 207889
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_20_sbc__slash_PKA_sbo_20_sbc__cplx

207889
type: LocalParameter
units: 257775
value: 5.4E-16

268164
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268152
type: SpeciesReference
stoichiometry: 1.0
species: 405260

268140
type: SpeciesReference
stoichiometry: 1.0
species: 403340

411219
type: Reaction
kinetic law: 269239
product: 269227
product: 269215
reactant: 269203
fast: false
reversible: false

269239
type: KineticLaw
local parameters: 207944
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx

207944
type: LocalParameter
units: 257775
value: 5.4E-16

269227
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269215
type: SpeciesReference
stoichiometry: 1.0
species: 405340

269203
type: SpeciesReference
stoichiometry: 1.0
species: 403560

403560
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

412639
type: Reaction
kinetic law: 272685
product: 272672
reactant: 272660
reactant: 272648
fast: false
reversible: true

272685
type: KineticLaw
local parameters: 208125
local parameters: 208123
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx

208125
type: LocalParameter
units: 257775
value: 1.4E-17

208123
type: LocalParameter
units: 257862
value: 8.7498E-18

272672
type: SpeciesReference
stoichiometry: 1.0
species: 404580

272660
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272648
type: SpeciesReference
stoichiometry: 1.0
species: 405600

408719
type: Reaction
kinetic law: 263041
product: 263029
product: 263017
reactant: 263005
fast: false
reversible: false

263041
type: KineticLaw
local parameters: 207625
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__PSD_cplx

207625
type: LocalParameter
units: 257775
value: 1.8E-16

263029
type: SpeciesReference
stoichiometry: 1.0
species: 401880

263017
type: SpeciesReference
stoichiometry: 1.0
species: 404260

263005
type: SpeciesReference
stoichiometry: 1.0
species: 401960

410599
type: Reaction
kinetic law: 267647
product: 267634
reactant: 267621
reactant: 267608
fast: false
reversible: true

267647
type: KineticLaw
local parameters: 207863
local parameters: 207861
notes: k1*PP1_PSD_slash_I1*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx

207863
type: LocalParameter
units: 257775
value: 3.24E-15

207861
type: LocalParameter
units: 257862
value: 5.99994E-17

267634
type: SpeciesReference
stoichiometry: 1.0
species: 403240

403240
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

267621
type: SpeciesReference
stoichiometry: 1.0
species: 403180

267608
type: SpeciesReference
stoichiometry: 1.0
species: 404200

403420
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

408519
type: Reaction
kinetic law: 262550
product: 262538
product: 262526
reactant: 262514
fast: false
reversible: false

262550
type: KineticLaw
local parameters: 207600
notes: k3*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_slash_CaM_minus_act_minus_305_minus_PSD_cplx

207600
type: LocalParameter
units: 257775
value: 6.0E-17

262538
type: SpeciesReference
stoichiometry: 1.0
species: 406120

262526
type: SpeciesReference
stoichiometry: 1.0
species: 400980

400980
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

262514
type: SpeciesReference
stoichiometry: 1.0
species: 401480

409759
type: Reaction
kinetic law: 265608
product: 265596
reactant: 265584
reactant: 265572
fast: false
reversible: true

265608
type: KineticLaw
local parameters: 207758
local parameters: 207756
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx

207758
type: LocalParameter
units: 257775
value: 7.2E-16

207756
type: LocalParameter
units: 257862
value: 1.8106416E-16

265596
type: SpeciesReference
stoichiometry: 1.0
species: 402600

265584
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265572
type: SpeciesReference
stoichiometry: 1.0
species: 405320

407319
type: Reaction
kinetic law: 259285
product: 259273
reactant: 259261
reactant: 259249
fast: false
reversible: true

259285
type: KineticLaw
local parameters: 207418
local parameters: 207416
notes: kf*PKA_slash_R2C2_minus_cAMP2*AC_slash_cAMP-kb*PKA_slash_R2C2_minus_cAMP3

207418
type: LocalParameter
units: 257775
value: 9.9E-15

207416
type: LocalParameter
units: 257862
value: 6.750054E-15

259273
type: SpeciesReference
stoichiometry: 1.0
species: 403060

403060
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

259261
type: SpeciesReference
stoichiometry: 1.0
species: 404160

259249
type: SpeciesReference
stoichiometry: 1.0
species: 403040

408059
type: Reaction
kinetic law: 261336
product: 261324
reactant: 261311
reactant: 261299
fast: false
reversible: true

261336
type: KineticLaw
local parameters: 207539
local parameters: 207537
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx

207539
type: LocalParameter
units: 257775
value: 2.0E-17

207537
type: LocalParameter
units: 257862
value: 2.77776E-19

261324
type: SpeciesReference
stoichiometry: 1.0
species: 401240

401240
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 7.1375E-215
initial amount: NaN
in compartment: 400700

261311
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261299
type: SpeciesReference
stoichiometry: 1.0
species: 405680

406400
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

412319
type: Reaction
kinetic law: 271900
product: 271888
reactant: 271876
reactant: 271864
fast: false
reversible: true

271900
type: KineticLaw
local parameters: 208084
local parameters: 208082
notes: k1*AMPAR_memb_slash_A845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx

208084
type: LocalParameter
units: 257775
value: 6.8E-18

208082
type: LocalParameter
units: 257862
value: 8.7498E-18

271888
type: SpeciesReference
stoichiometry: 1.0
species: 404420

271876
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271864
type: SpeciesReference
stoichiometry: 1.0
species: 405580

413219
type: Reaction
kinetic law: 274083
product: 274071
product: 274059
reactant: 274047
fast: false
reversible: false

274083
type: KineticLaw
local parameters: 208197
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx

208197
type: LocalParameter
units: 257775
value: 3.5E-18

274071
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274059
type: SpeciesReference
stoichiometry: 1.0
species: 405780

274047
type: SpeciesReference
stoichiometry: 1.0
species: 404860

410939
type: Reaction
kinetic law: 268514
product: 268502
reactant: 268490
reactant: 268478
fast: false
reversible: true

268514
type: KineticLaw
local parameters: 207908
local parameters: 207906
notes: k1*AMPAR_slash_A_B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx

207908
type: LocalParameter
units: 257775
value: 2.16E-15

207906
type: LocalParameter
units: 257862
value: 3.5998992E-16

268502
type: SpeciesReference
stoichiometry: 1.0
species: 403420

268490
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268478
type: SpeciesReference
stoichiometry: 1.0
species: 405260

401760
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

402800
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

412239
type: Reaction
kinetic law: 271707
product: 271695
reactant: 271683
reactant: 271671
fast: false
reversible: true

271707
type: KineticLaw
local parameters: 208074
local parameters: 208072
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx

208074
type: LocalParameter
units: 257775
value: 6.8E-18

208072
type: LocalParameter
units: 257862
value: 8.7498E-18

271695
type: SpeciesReference
stoichiometry: 1.0
species: 404380

404380
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

271683
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271671
type: SpeciesReference
stoichiometry: 1.0
species: 405680

413019
type: Reaction
kinetic law: 273599
product: 273586
product: 273574
reactant: 273562
fast: false
reversible: false

273599
type: KineticLaw
local parameters: 208172
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_19_sbc__slash_PP1_sbo_19_sbc__cplx

208172
type: LocalParameter
units: 257775
value: 1.7E-18

273586
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273574
type: SpeciesReference
stoichiometry: 1.0
species: 405560

273562
type: SpeciesReference
stoichiometry: 1.0
species: 404760

410219
type: Reaction
kinetic law: 266720
product: 266708
product: 266696
reactant: 266683
fast: false
reversible: false

266720
type: KineticLaw
local parameters: 207814
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_9_sbc__slash_PP2B_sbo_9_sbc__cplx

207814
type: LocalParameter
units: 257775
value: 1.8E-16

266708
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266696
type: SpeciesReference
stoichiometry: 1.0
species: 405660

266683
type: SpeciesReference
stoichiometry: 1.0
species: 402840

412039
type: Reaction
kinetic law: 271225
product: 271213
reactant: 271201
reactant: 271189
notes: Max activity ~10umol/min/mg in presence of lots of CaM. Affinity is low, 40 uM. k3 = 10, k2 = 40, k1 = (50/40) / 6e5.
fast: false
reversible: true

271225
type: KineticLaw
local parameters: 208049
local parameters: 208047
notes: k1*AC_slash_cAMP*AC_slash_CaM_dot_PDE1-k2*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx

208049
type: LocalParameter
units: 257775
value: 3.6E-15

208047
type: LocalParameter
units: 257862
value: 1.1339838E-16

271213
type: SpeciesReference
stoichiometry: 1.0
species: 404120

271201
type: SpeciesReference
stoichiometry: 1.0
species: 404100

271189
type: SpeciesReference
stoichiometry: 1.0
species: 404160

413699
type: Reaction
kinetic law: 275254
product: 275242
product: 275230
reactant: 275218
fast: false
reversible: false

275254
type: KineticLaw
local parameters: 208257
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_PSD_slash_PKC_minus_phosph_minus_neurogranin_PSD_cplx

208257
type: LocalParameter
units: 257775
value: 5.22E-17

275242
type: SpeciesReference
stoichiometry: 1.0
species: 405040

275230
type: SpeciesReference
stoichiometry: 1.0
species: 401660

275218
type: SpeciesReference
stoichiometry: 1.0
species: 405120

402540
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

408419
type: Reaction
kinetic law: 262308
product: 262296
reactant: 262284
reactant: 262272
fast: false
reversible: true

262308
type: KineticLaw
local parameters: 207589
local parameters: 207587
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx

207589
type: LocalParameter
units: 257775
value: 2.0E-17

207587
type: LocalParameter
units: 257862
value: 2.77776E-19

262296
type: SpeciesReference
stoichiometry: 1.0
species: 401440

401440
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.04433333333333E-215
initial amount: NaN
in compartment: 400700

262284
type: SpeciesReference
stoichiometry: 1.0
species: 406100

262272
type: SpeciesReference
stoichiometry: 1.0
species: 405600

407479
type: Reaction
kinetic law: 259927
product: 259915
product: 259903
reactant: 259890
fast: false
reversible: true

259927
type: KineticLaw
local parameters: 207460
local parameters: 207458
notes: kf*AMPAR_memb_slash_A831_star__B-kb*AMPAR_slash_A831_star__B*AMPAR_memb_slash_Anchor

207460
type: LocalParameter
units: 257862
value: 0.0

207458
type: LocalParameter
units: 257775
value: 8.0E-21

259915
type: SpeciesReference
stoichiometry: 1.0
species: 405840

259903
type: SpeciesReference
stoichiometry: 1.0
species: 405200

259890
type: SpeciesReference
stoichiometry: 1.0
species: 405520

413359
type: Reaction
kinetic law: 274422
product: 274410
reactant: 274398
reactant: 274385
fast: false
reversible: true

274422
type: KineticLaw
local parameters: 208216
local parameters: 208214
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx

208216
type: LocalParameter
units: 257775
value: 1.4E-17

208214
type: LocalParameter
units: 257862
value: 8.7498E-18

274410
type: SpeciesReference
stoichiometry: 1.0
species: 404940

404940
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

274398
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274385
type: SpeciesReference
stoichiometry: 1.0
species: 405800

406340
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

407279
type: Reaction
kinetic law: 259091
product: 259078
reactant: 259065
reactant: 259052
notes: going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1.
fast: false
reversible: true

259091
type: KineticLaw
local parameters: 207406
local parameters: 207404
notes: kf*PP2B_slash_CaNAB*Ca^2-kb*PP2B_slash_CaNAB_minus_Ca2

207406
type: LocalParameter
units: 257775
value: 9.0E-17

207404
type: LocalParameter
units: 257811
value: 9.00720324E-13

259078
type: SpeciesReference
stoichiometry: 1.0
species: 402120

259065
type: SpeciesReference
stoichiometry: 2.0
species: 400740

259052
type: SpeciesReference
stoichiometry: 1.0
species: 402100

402100
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 400680

406860
type: Reaction
kinetic law: 257976
product: 257964
reactant: 257952
reactant: 257939
notes: This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
fast: false
reversible: true

257976
type: KineticLaw
local parameters: 207334
local parameters: 207332
notes: kf*CaM_slash_CaM_minus_Ca4*CaMKII_slash_CaMKII-kb*CaMKII_slash_CaMKII_minus_CaM

207334
type: LocalParameter
units: 257775
value: 4.5E-16

207332
type: LocalParameter
units: 257862
value: 4.4999712E-15

257964
type: SpeciesReference
stoichiometry: 1.0
species: 400780

257952
type: SpeciesReference
stoichiometry: 1.0
species: 400760

257939
type: SpeciesReference
stoichiometry: 1.0
species: 401780

407320
type: Reaction
kinetic law: 259333
product: 259321
reactant: 259309
reactant: 259297
fast: false
reversible: true

259333
type: KineticLaw
local parameters: 207421
local parameters: 207419
notes: kf*AC_slash_cAMP*PKA_slash_R2C2_minus_cAMP3-kb*PKA_slash_R2C2_minus_cAMP4

207421
type: LocalParameter
units: 257775
value: 2.925E-15

207419
type: LocalParameter
units: 257862
value: 6.750054E-15

259321
type: SpeciesReference
stoichiometry: 1.0
species: 403080

403080
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

259309
type: SpeciesReference
stoichiometry: 1.0
species: 403060

259297
type: SpeciesReference
stoichiometry: 1.0
species: 404160

407919
type: Reaction
kinetic law: 260995
product: 260983
product: 260971
reactant: 260959
fast: false
reversible: false

260995
type: KineticLaw
local parameters: 207520
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_slash_CaMKII_cplx

207520
type: LocalParameter
units: 257775
value: 5.0E-18

260983
type: SpeciesReference
stoichiometry: 1.0
species: 406100

260971
type: SpeciesReference
stoichiometry: 1.0
species: 405760

260959
type: SpeciesReference
stoichiometry: 1.0
species: 401160

404880
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

408239
type: Reaction
kinetic law: 261821
product: 261809
reactant: 261797
reactant: 261785
fast: false
reversible: true

261821
type: KineticLaw
local parameters: 207564
local parameters: 207562
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx

207564
type: LocalParameter
units: 257775
value: 2.0E-17

207562
type: LocalParameter
units: 257862
value: 2.77776E-19

261809
type: SpeciesReference
stoichiometry: 1.0
species: 401340

261797
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261785
type: SpeciesReference
stoichiometry: 1.0
species: 405720

407839
type: Reaction
kinetic law: 260801
product: 260789
product: 260777
reactant: 260765
fast: false
reversible: false

260801
type: KineticLaw
local parameters: 207511
notes: k3*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_305_minus_PSD_slash_auton_minus_305_minus_PSD_cplx

207511
type: LocalParameter
units: 257775
value: 6.0E-17

260789
type: SpeciesReference
stoichiometry: 1.0
species: 406060

260777
type: SpeciesReference
stoichiometry: 1.0
species: 400980

260765
type: SpeciesReference
stoichiometry: 1.0
species: 401100

413179
type: Reaction
kinetic law: 273987
product: 273975
product: 273963
reactant: 273951
fast: false
reversible: false

273987
type: KineticLaw
local parameters: 208192
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_23_sbc__slash_PP1_sbo_23_sbc__cplx

208192
type: LocalParameter
units: 257775
value: 3.5E-18

273975
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273963
type: SpeciesReference
stoichiometry: 1.0
species: 405500

273951
type: SpeciesReference
stoichiometry: 1.0
species: 404840

408819
type: Reaction
kinetic law: 263284
product: 263272
reactant: 263259
reactant: 263247
fast: false
reversible: true

263284
type: KineticLaw
local parameters: 207639
local parameters: 207637
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

207639
type: LocalParameter
units: 257775
value: 9.0E-16

207637
type: LocalParameter
units: 257862
value: 2.2062942E-16

263272
type: SpeciesReference
stoichiometry: 1.0
species: 402040

402040
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

263259
type: SpeciesReference
stoichiometry: 1.0
species: 401980

263247
type: SpeciesReference
stoichiometry: 1.0
species: 400820

411979
type: Reaction
kinetic law: 271079
product: 271067
product: 271055
reactant: 271043
fast: false
reversible: false

271079
type: KineticLaw
local parameters: 208040
notes: k3*AC_slash_cAMP_minus_PDE_star__slash_PDE_star__slash_PDE_star__cplx

208040
type: LocalParameter
units: 257775
value: 1.8E-15

271067
type: SpeciesReference
stoichiometry: 1.0
species: 404020

271055
type: SpeciesReference
stoichiometry: 1.0
species: 403960

271043
type: SpeciesReference
stoichiometry: 1.0
species: 404040

412439
type: Reaction
kinetic law: 272189
product: 272177
reactant: 272165
reactant: 272152
fast: false
reversible: true

272189
type: KineticLaw
local parameters: 208099
local parameters: 208097
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx

208099
type: LocalParameter
units: 257775
value: 6.8E-18

208097
type: LocalParameter
units: 257862
value: 8.7498E-18

272177
type: SpeciesReference
stoichiometry: 1.0
species: 404480

272165
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272152
type: SpeciesReference
stoichiometry: 1.0
species: 405760

407639
type: Reaction
kinetic law: 260316
product: 260303
reactant: 260291
fast: false
reversible: true

260316
type: KineticLaw
local parameters: 207487
local parameters: 207485
notes: kf*Ca_control_PSD-kb*Ca_minus_PSD

207487
type: LocalParameter
units: 257775
value: 1.0E-15

207485
type: LocalParameter
units: 257775
value: 1.0E-15

260303
type: SpeciesReference
stoichiometry: 1.0
species: 404180

260291
type: SpeciesReference
stoichiometry: 1.0
species: 405960

405960
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 400700

404680
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

408619
type: Reaction
kinetic law: 262800
product: 262788
reactant: 262776
reactant: 262764
notes: k1 changed from 3.3e-6 to 6.6e-6
fast: false
reversible: true

262800
type: KineticLaw
local parameters: 207614
local parameters: 207612
notes: k1*PP1_slash_PP1_minus_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx

207614
type: LocalParameter
units: 257775
value: 7.50006E-16

207612
type: LocalParameter
units: 257862
value: 5.81256E-17

262788
type: SpeciesReference
stoichiometry: 1.0
species: 401920

401920
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00691
initial amount: NaN
in compartment: 400680

262776
type: SpeciesReference
stoichiometry: 1.0
species: 401880

262764
type: SpeciesReference
stoichiometry: 1.0
species: 401840

411239
type: Reaction
kinetic law: 269288
product: 269276
reactant: 269263
reactant: 269251
fast: false
reversible: true

269288
type: KineticLaw
local parameters: 207948
local parameters: 207946
notes: k1*AMPAR_memb_slash_A_B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_slash_PKA_cplx

207948
type: LocalParameter
units: 257775
value: 2.16E-15

207946
type: LocalParameter
units: 257862
value: 3.999888E-17

269276
type: SpeciesReference
stoichiometry: 1.0
species: 403580

403580
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

269263
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269251
type: SpeciesReference
stoichiometry: 1.0
species: 405640

400880
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.44537037037037E-8
initial amount: NaN
in compartment: 400680

411039
type: Reaction
kinetic law: 268754
product: 268742
product: 268730
reactant: 268718
fast: false
reversible: false

268754
type: KineticLaw
local parameters: 207919
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_26_sbc__slash_PKA_sbo_26_sbc__cplx

207919
type: LocalParameter
units: 257775
value: 5.4E-16

268742
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268730
type: SpeciesReference
stoichiometry: 1.0
species: 405320

268718
type: SpeciesReference
stoichiometry: 1.0
species: 403460

403140
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.259259259259259
initial amount: NaN
in compartment: 400680

413539
type: Reaction
kinetic law: 274856
product: 274844
product: 274832
reactant: 274820
fast: false
reversible: false

274856
type: KineticLaw
local parameters: 208237
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

208237
type: LocalParameter
units: 257775
value: 2.5E-17

274844
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274832
type: SpeciesReference
stoichiometry: 1.0
species: 401000

274820
type: SpeciesReference
stoichiometry: 1.0
species: 405020

405020
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

408539
type: Reaction
kinetic law: 262602
product: 262589
reactant: 262576
reactant: 262563
fast: false
reversible: true

262602
type: KineticLaw
local parameters: 207604
local parameters: 207602
notes: k1*CaMKII_slash_CaMKII_minus_CaM_minus_PSD*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD-k2*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx

207604
type: LocalParameter
units: 257775
value: 2.0E-17

207602
type: LocalParameter
units: 257862
value: 3.07998E-19

262589
type: SpeciesReference
stoichiometry: 1.0
species: 401500

401500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

262576
type: SpeciesReference
stoichiometry: 1.0
species: 406120

262563
type: SpeciesReference
stoichiometry: 1.0
species: 401060

401060
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

413345
type: Reaction
kinetic law: 274373
product: 274361
product: 274349
reactant: 274337
fast: false
reversible: false

274373
type: KineticLaw
local parameters: 208212
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_27_sbc__slash_PP1_sbo_27_sbc__cplx

208212
type: LocalParameter
units: 257775
value: 3.5E-18

274361
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274349
type: SpeciesReference
stoichiometry: 1.0
species: 405540

274337
type: SpeciesReference
stoichiometry: 1.0
species: 404920

411379
type: Reaction
kinetic law: 269629
product: 269617
product: 269605
reactant: 269592
fast: false
reversible: false

269629
type: KineticLaw
local parameters: 207964
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_3_sbc__slash_PKA_sbo_3_sbc__cplx

207964
type: LocalParameter
units: 257775
value: 5.4E-16

269617
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269605
type: SpeciesReference
stoichiometry: 1.0
species: 405640

269592
type: SpeciesReference
stoichiometry: 1.0
species: 403640

409779
type: Reaction
kinetic law: 265656
product: 265644
product: 265632
reactant: 265620
fast: false
reversible: false

265656
type: KineticLaw
local parameters: 207759
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_31_sbc__slash_PP2B_sbo_31_sbc__cplx

207759
type: LocalParameter
units: 257775
value: 1.8E-16

265644
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265632
type: SpeciesReference
stoichiometry: 1.0
species: 405420

265620
type: SpeciesReference
stoichiometry: 1.0
species: 402600

409019
type: Reaction
kinetic law: 263818
product: 263806
product: 263794
reactant: 263782
fast: false
reversible: false

263818
type: KineticLaw
local parameters: 207664
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_slash_dephosph_neurogranin_cplx

207664
type: LocalParameter
units: 257775
value: 6.03E-17

263806
type: SpeciesReference
stoichiometry: 1.0
species: 402200

263794
type: SpeciesReference
stoichiometry: 1.0
species: 401580

263782
type: SpeciesReference
stoichiometry: 1.0
species: 402220

404340
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

409579
type: Reaction
kinetic law: 265173
product: 265161
product: 265149
reactant: 265136
fast: false
reversible: false

265173
type: KineticLaw
local parameters: 207734
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_26_sbc__slash_PP2B_sbo_26_sbc__cplx

207734
type: LocalParameter
units: 257775
value: 1.8E-16

265161
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265149
type: SpeciesReference
stoichiometry: 1.0
species: 405480

265136
type: SpeciesReference
stoichiometry: 1.0
species: 402500

409439
type: Reaction
kinetic law: 264836
product: 264824
reactant: 264812
reactant: 264800
fast: false
reversible: true

264836
type: KineticLaw
local parameters: 207718
local parameters: 207716
notes: k1*AMPAR_slash_A_B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx

207718
type: LocalParameter
units: 257775
value: 7.2E-16

207716
type: LocalParameter
units: 257862
value: 1.8106416E-16

264824
type: SpeciesReference
stoichiometry: 1.0
species: 402440

402440
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

264812
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264800
type: SpeciesReference
stoichiometry: 1.0
species: 405360

412339
type: Reaction
kinetic law: 271948
product: 271936
product: 271924
reactant: 271912
fast: false
reversible: false

271948
type: KineticLaw
local parameters: 208085
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_2_sbc__slash_PP1_sbo_2_sbc__cplx

208085
type: LocalParameter
units: 257775
value: 1.7E-18

271936
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271924
type: SpeciesReference
stoichiometry: 1.0
species: 405500

271912
type: SpeciesReference
stoichiometry: 1.0
species: 404420

412139
type: Reaction
kinetic law: 271465
product: 271453
product: 271441
reactant: 271429
fast: false
reversible: false

271465
type: KineticLaw
local parameters: 208060
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286b_slash_Deph_minus_thr286b_cplx

208060
type: LocalParameter
units: 257775
value: 2.5E-17

271453
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271441
type: SpeciesReference
stoichiometry: 1.0
species: 401000

271429
type: SpeciesReference
stoichiometry: 1.0
species: 404320

411199
type: Reaction
kinetic law: 269191
product: 269179
reactant: 269166
reactant: 269154
fast: false
reversible: true

269191
type: KineticLaw
local parameters: 207943
local parameters: 207941
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_31_sbc__slash_PKA_sbo_31_sbc__cplx

207943
type: LocalParameter
units: 257775
value: 2.16E-15

207941
type: LocalParameter
units: 257862
value: 3.5998992E-16

269179
type: SpeciesReference
stoichiometry: 1.0
species: 403560

269166
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269154
type: SpeciesReference
stoichiometry: 1.0
species: 405460

410019
type: Reaction
kinetic law: 266238
product: 266226
product: 266214
reactant: 266202
fast: false
reversible: false

266238
type: KineticLaw
local parameters: 207789
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx

207789
type: LocalParameter
units: 257775
value: 1.8E-16

266226
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266214
type: SpeciesReference
stoichiometry: 1.0
species: 405700

266202
type: SpeciesReference
stoichiometry: 1.0
species: 402740

413039
type: Reaction
kinetic law: 273647
product: 273635
reactant: 273623
reactant: 273611
fast: false
reversible: true

273647
type: KineticLaw
local parameters: 208176
local parameters: 208174
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx

208176
type: LocalParameter
units: 257775
value: 1.4E-17

208174
type: LocalParameter
units: 257862
value: 8.7498E-18

273635
type: SpeciesReference
stoichiometry: 1.0
species: 404780

404780
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

273623
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273611
type: SpeciesReference
stoichiometry: 1.0
species: 405720

410619
type: Reaction
kinetic law: 267696
product: 267684
product: 267672
reactant: 267660
fast: false
reversible: false

267696
type: KineticLaw
local parameters: 207864
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_minus_phosph_minus_I1_PSD_slash_PKA_minus_phosph_minus_I1_PSD_cplx

207864
type: LocalParameter
units: 257775
value: 8.1E-16

267684
type: SpeciesReference
stoichiometry: 1.0
species: 403180

267672
type: SpeciesReference
stoichiometry: 1.0
species: 404220

267660
type: SpeciesReference
stoichiometry: 1.0
species: 403240

412059
type: Reaction
kinetic law: 271273
product: 271261
product: 271249
reactant: 271237
fast: false
reversible: false

271273
type: KineticLaw
local parameters: 208050
notes: k3*AC_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_slash_CaM_dot_PDE1_cplx

208050
type: LocalParameter
units: 257775
value: 9.0E-16

271261
type: SpeciesReference
stoichiometry: 1.0
species: 404100

271249
type: SpeciesReference
stoichiometry: 1.0
species: 403960

271237
type: SpeciesReference
stoichiometry: 1.0
species: 404120

406160
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

411719
type: Reaction
kinetic law: 270450
product: 270438
reactant: 270426
reactant: 270413
fast: false
reversible: true

270450
type: KineticLaw
local parameters: 208008
local parameters: 208006
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx

208008
type: LocalParameter
units: 257775
value: 2.16E-15

208006
type: LocalParameter
units: 257862
value: 3.999888E-17

270438
type: SpeciesReference
stoichiometry: 1.0
species: 403820

403820
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

270426
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270413
type: SpeciesReference
stoichiometry: 1.0
species: 405740

407340
type: Reaction
kinetic law: 259429
product: 259417
product: 259405
reactant: 259393
fast: false
reversible: true

259429
type: KineticLaw
local parameters: 207427
local parameters: 207425
notes: kf*PKA_slash_R2C_minus_cAMP4-kb*PKA_slash_PKA_minus_active*PKA_slash_R2_minus_cAMP4

207427
type: LocalParameter
units: 257862
value: 1.6199838E-15

207425
type: LocalParameter
units: 257775
value: 5.4E-15

259417
type: SpeciesReference
stoichiometry: 1.0
species: 403120

259405
type: SpeciesReference
stoichiometry: 1.0
species: 403180

259393
type: SpeciesReference
stoichiometry: 1.0
species: 403100

405860
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400680

413379
type: Reaction
kinetic law: 274470
product: 274458
product: 274446
reactant: 274434
fast: false
reversible: false

274470
type: KineticLaw
local parameters: 208217
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_28_sbc__slash_PP1_sbo_28_sbc__cplx

208217
type: LocalParameter
units: 257775
value: 3.5E-18

274458
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274446
type: SpeciesReference
stoichiometry: 1.0
species: 405760

274434
type: SpeciesReference
stoichiometry: 1.0
species: 404940

409979
type: Reaction
kinetic law: 266142
product: 266130
product: 266117
reactant: 266105
fast: false
reversible: false

266142
type: KineticLaw
local parameters: 207784
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_3_sbc__slash_PP2B_sbo_3_sbc__cplx

207784
type: LocalParameter
units: 257775
value: 1.8E-16

266130
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266117
type: SpeciesReference
stoichiometry: 1.0
species: 405500

266105
type: SpeciesReference
stoichiometry: 1.0
species: 402720

407299
type: Reaction
kinetic law: 259188
product: 259176
reactant: 259164
reactant: 259152
notes: Hasler et al FASEB J 6:2734-2741 1992 say Kd =1e-7M for type II, 5.6e-8 M for type I. Take mean which comes to 2e-13 #/cell Smith et al PNAS USA 78:3 1591-1595 1981 have better data. First kf/kb=2.1e7/M = 3.5e-5 (#/cell). Ogreid and Doskeland Febs Lett 129:2 287-292 1981 have figs suggesting time course of complete assoc is < 1 min.
fast: false
reversible: true

259188
type: KineticLaw
local parameters: 207412
local parameters: 207410
notes: kf*PKA_slash_R2C2*AC_slash_cAMP-kb*PKA_slash_R2C2_minus_cAMP

207412
type: LocalParameter
units: 257775
value: 2.97E-15

207410
type: LocalParameter
units: 257862
value: 4.86E-15

259176
type: SpeciesReference
stoichiometry: 1.0
species: 403020

403020
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

259164
type: SpeciesReference
stoichiometry: 1.0
species: 404160

259152
type: SpeciesReference
stoichiometry: 1.0
species: 403000

407939
type: Reaction
kinetic law: 261044
product: 261032
reactant: 261020
reactant: 261007
fast: false
reversible: true

261044
type: KineticLaw
local parameters: 207524
local parameters: 207522
notes: k1*AMPAR_memb_slash_A_B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx

207524
type: LocalParameter
units: 257775
value: 2.0E-17

207522
type: LocalParameter
units: 257862
value: 2.77776E-19

261032
type: SpeciesReference
stoichiometry: 1.0
species: 401180

401180
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.588E-215
initial amount: NaN
in compartment: 400700

261020
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261007
type: SpeciesReference
stoichiometry: 1.0
species: 405640

407300
type: Reaction
kinetic law: 259237
product: 259225
reactant: 259213
reactant: 259200
notes: For now let us set this to the same Km (1e-7M) as site B. This gives kf/kb = .7e-7M * 1e6 / (6e5^2) : 1/(6e5^2) = 2e-13:2.77e-12 Smith et al have better values. They say that this is cooperative, so the consts are now kf/kb =8.3e-4
fast: false
reversible: true

259237
type: KineticLaw
local parameters: 207415
local parameters: 207413
notes: kf*PKA_slash_R2C2_minus_cAMP*AC_slash_cAMP-kb*PKA_slash_R2C2_minus_cAMP2

207415
type: LocalParameter
units: 257775
value: 2.97E-15

207413
type: LocalParameter
units: 257862
value: 4.86E-15

259225
type: SpeciesReference
stoichiometry: 1.0
species: 403040

259213
type: SpeciesReference
stoichiometry: 1.0
species: 404160

259200
type: SpeciesReference
stoichiometry: 1.0
species: 403020

407140
type: Reaction
kinetic law: 258628
product: 258616
reactant: 258604
reactant: 258592
notes: Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
fast: false
reversible: true

258628
type: KineticLaw
local parameters: 207376
local parameters: 207374
notes: kf*CaM_slash_CaM_minus_PSD*Ca_minus_PSD^2-kb*CaM_slash_CaM_minus_TR2_minus_Ca2_minus_PSD

207376
type: LocalParameter
units: 257775
value: 7.2E-16

207374
type: LocalParameter
units: 257811
value: 7.2E-16

258616
type: SpeciesReference
stoichiometry: 1.0
species: 401760

258604
type: SpeciesReference
stoichiometry: 2.0
species: 404180

258592
type: SpeciesReference
stoichiometry: 1.0
species: 401600

411559
type: Reaction
kinetic law: 270062
product: 270050
reactant: 270038
reactant: 270026
fast: false
reversible: true

270062
type: KineticLaw
local parameters: 207988
local parameters: 207986
notes: k1*AMPAR_memb_slash_A_B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx

207988
type: LocalParameter
units: 257775
value: 2.16E-15

207986
type: LocalParameter
units: 257862
value: 3.999888E-17

270050
type: SpeciesReference
stoichiometry: 1.0
species: 403740

403740
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

270038
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270026
type: SpeciesReference
stoichiometry: 1.0
species: 405720

402620
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

411519
type: Reaction
kinetic law: 269966
product: 269954
reactant: 269942
reactant: 269930
fast: false
reversible: true

269966
type: KineticLaw
local parameters: 207983
local parameters: 207981
notes: k1*AMPAR_memb_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx

207983
type: LocalParameter
units: 257775
value: 2.16E-15

207981
type: LocalParameter
units: 257862
value: 3.999888E-17

269954
type: SpeciesReference
stoichiometry: 1.0
species: 403720

269942
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269930
type: SpeciesReference
stoichiometry: 1.0
species: 405520

412539
type: Reaction
kinetic law: 272436
product: 272423
product: 272409
reactant: 272396
fast: false
reversible: false

272436
type: KineticLaw
local parameters: 208110
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx

208110
type: LocalParameter
units: 257775
value: 1.7E-18

272423
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272409
type: SpeciesReference
stoichiometry: 1.0
species: 405520

272396
type: SpeciesReference
stoichiometry: 1.0
species: 404520

408080
type: Reaction
kinetic law: 261433
product: 261421
reactant: 261409
reactant: 261397
fast: false
reversible: true

261433
type: KineticLaw
local parameters: 207544
local parameters: 207542
notes: k1*AMPAR_memb_slash_A_B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_5_sbc__slash_CaMKII_sbo_5_sbc__cplx

207544
type: LocalParameter
units: 257775
value: 2.0E-17

207542
type: LocalParameter
units: 257862
value: 2.77776E-19

261421
type: SpeciesReference
stoichiometry: 1.0
species: 401260

261409
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261397
type: SpeciesReference
stoichiometry: 1.0
species: 405640

407480
type: Reaction
kinetic law: 259975
product: 259963
product: 259951
reactant: 259939
fast: false
reversible: true

259975
type: KineticLaw
local parameters: 207463
local parameters: 207461
notes: kf*AMPAR_memb_slash_A_B-kb*AMPAR_slash_A_B*AMPAR_memb_slash_Anchor

207463
type: LocalParameter
units: 257862
value: 0.0

207461
type: LocalParameter
units: 257775
value: 8.0E-21

259963
type: SpeciesReference
stoichiometry: 1.0
species: 405840

259951
type: SpeciesReference
stoichiometry: 1.0
species: 405180

259939
type: SpeciesReference
stoichiometry: 1.0
species: 405500

413199
type: Reaction
kinetic law: 274035
product: 274023
reactant: 274011
reactant: 273999
fast: false
reversible: true

274035
type: KineticLaw
local parameters: 208196
local parameters: 208194
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_24_sbc__slash_PP1_sbo_24_sbc__cplx

208196
type: LocalParameter
units: 257775
value: 1.4E-17

208194
type: LocalParameter
units: 257862
value: 8.7498E-18

274023
type: SpeciesReference
stoichiometry: 1.0
species: 404860

274011
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273999
type: SpeciesReference
stoichiometry: 1.0
species: 405800

412839
type: Reaction
kinetic law: 273166
product: 273154
reactant: 273142
reactant: 273130
fast: false
reversible: true

273166
type: KineticLaw
local parameters: 208151
local parameters: 208149
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx

208151
type: LocalParameter
units: 257775
value: 6.8E-18

208149
type: LocalParameter
units: 257862
value: 8.7498E-18

273154
type: SpeciesReference
stoichiometry: 1.0
species: 404680

273142
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273130
type: SpeciesReference
stoichiometry: 1.0
species: 405660

412459
type: Reaction
kinetic law: 272237
product: 272225
product: 272213
reactant: 272201
fast: false
reversible: false

272237
type: KineticLaw
local parameters: 208100
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_5_sbc__slash_PP1_sbo_5_sbc__cplx

208100
type: LocalParameter
units: 257775
value: 1.7E-18

272225
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272213
type: SpeciesReference
stoichiometry: 1.0
species: 405600

272201
type: SpeciesReference
stoichiometry: 1.0
species: 404480

408339
type: Reaction
kinetic law: 262066
product: 262054
product: 262042
reactant: 262030
fast: false
reversible: false

262066
type: KineticLaw
local parameters: 207575
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_11_sbc__slash_CaMKII_sbo_11_sbc__cplx

207575
type: LocalParameter
units: 257775
value: 5.0E-18

262054
type: SpeciesReference
stoichiometry: 1.0
species: 406100

262042
type: SpeciesReference
stoichiometry: 1.0
species: 405560

262030
type: SpeciesReference
stoichiometry: 1.0
species: 401380

412879
type: Reaction
kinetic law: 273262
product: 273250
reactant: 273238
reactant: 273226
fast: false
reversible: true

273262
type: KineticLaw
local parameters: 208156
local parameters: 208154
notes: k1*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx

208156
type: LocalParameter
units: 257775
value: 6.8E-18

208154
type: LocalParameter
units: 257862
value: 8.7498E-18

273250
type: SpeciesReference
stoichiometry: 1.0
species: 404700

404700
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

273238
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273226
type: SpeciesReference
stoichiometry: 1.0
species: 405800

412419
type: Reaction
kinetic law: 272140
product: 272128
product: 272116
reactant: 272104
fast: false
reversible: false

272140
type: KineticLaw
local parameters: 208095
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_4_sbc__slash_PP1_sbo_4_sbc__cplx

208095
type: LocalParameter
units: 257775
value: 1.7E-18

272128
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272116
type: SpeciesReference
stoichiometry: 1.0
species: 405700

272104
type: SpeciesReference
stoichiometry: 1.0
species: 404460

406900
type: Reaction
kinetic law: 258072
product: 258060
product: 258048
reactant: 258036
notes: Same as for back_1
fast: false
reversible: true

258072
type: KineticLaw
local parameters: 207340
local parameters: 207338
notes: kf*CaMKII_slash_CaMKII_minus_thr305_minus_PSD-kb*CaMKII_slash_CaMK_minus_thr305*CaMKII_slash_NMDAR

207340
type: LocalParameter
units: 257862
value: 5.4E-21

207338
type: LocalParameter
units: 257775
value: 3.0E-18

258060
type: SpeciesReference
stoichiometry: 1.0
species: 401020

258048
type: SpeciesReference
stoichiometry: 1.0
species: 400940

258036
type: SpeciesReference
stoichiometry: 1.0
species: 400960

407659
type: Reaction
kinetic law: 260365
product: 260353
reactant: 260340
reactant: 260328
notes: Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
fast: false
reversible: true

260365
type: KineticLaw
local parameters: 207490
local parameters: 207488
notes: k1*CaMKII_slash_CaMKII_minus_thr286*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx

207490
type: LocalParameter
units: 257775
value: 2.16E-15

207488
type: LocalParameter
units: 257862
value: 2.3767344E-17

260353
type: SpeciesReference
stoichiometry: 1.0
species: 400860

260340
type: SpeciesReference
stoichiometry: 1.0
species: 405980

260328
type: SpeciesReference
stoichiometry: 1.0
species: 400840

402760
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

408639
type: Reaction
kinetic law: 262848
product: 262836
product: 262824
reactant: 262812
fast: false
reversible: false

262848
type: KineticLaw
local parameters: 207615
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__slash_PP2A_minus_dephosph_minus_PP1_minus_I_star__cplx

207615
type: LocalParameter
units: 257775
value: 1.8E-16

262836
type: SpeciesReference
stoichiometry: 1.0
species: 401880

262824
type: SpeciesReference
stoichiometry: 1.0
species: 401860

262812
type: SpeciesReference
stoichiometry: 1.0
species: 401920

411059
type: Reaction
kinetic law: 268802
product: 268790
reactant: 268778
reactant: 268766
fast: false
reversible: true

268802
type: KineticLaw
local parameters: 207923
local parameters: 207921
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx

207923
type: LocalParameter
units: 257775
value: 2.16E-15

207921
type: LocalParameter
units: 257862
value: 3.5998992E-16

268790
type: SpeciesReference
stoichiometry: 1.0
species: 403480

268778
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268766
type: SpeciesReference
stoichiometry: 1.0
species: 405380

408400
type: Reaction
kinetic law: 262260
product: 262248
product: 262236
reactant: 262223
fast: false
reversible: false

262260
type: KineticLaw
local parameters: 207585
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_13_sbc__slash_CaMKII_sbo_13_sbc__cplx

207585
type: LocalParameter
units: 257775
value: 5.0E-18

262248
type: SpeciesReference
stoichiometry: 1.0
species: 406100

262236
type: SpeciesReference
stoichiometry: 1.0
species: 405740

262223
type: SpeciesReference
stoichiometry: 1.0
species: 401420

413559
type: Reaction
kinetic law: 274905
product: 274893
reactant: 274881
reactant: 274868
notes: Rates from Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

274905
type: KineticLaw
local parameters: 208241
local parameters: 208239
notes: k1*CaM_slash_neurogranin*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx

208241
type: LocalParameter
units: 257775
value: 2.106E-16

208239
type: LocalParameter
units: 257862
value: 9.180054E-18

274893
type: SpeciesReference
stoichiometry: 1.0
species: 405060

405060
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00538592592592593
initial amount: NaN
in compartment: 400680

274881
type: SpeciesReference
stoichiometry: 1.0
species: 405040

274868
type: SpeciesReference
stoichiometry: 1.0
species: 401580

409119
type: Reaction
kinetic law: 264061
product: 264049
reactant: 264037
reactant: 264025
fast: false
reversible: true

264061
type: KineticLaw
local parameters: 207678
local parameters: 207676
notes: k1*PP1_PSD_slash_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx

207678
type: LocalParameter
units: 257775
value: 1.224E-16

207676
type: LocalParameter
units: 257862
value: 3.420036E-18

264049
type: SpeciesReference
stoichiometry: 1.0
species: 402280

264037
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264025
type: SpeciesReference
stoichiometry: 1.0
species: 404220

413519
type: Reaction
kinetic law: 274808
product: 274796
reactant: 274784
reactant: 274772
fast: false
reversible: true

274808
type: KineticLaw
local parameters: 208236
local parameters: 208234
notes: k1*CaMKII_slash_CaMKII_minus_thr305_minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

208236
type: LocalParameter
units: 257775
value: 1.0E-16

208234
type: LocalParameter
units: 257862
value: 2.45142E-17

274796
type: SpeciesReference
stoichiometry: 1.0
species: 405020

274784
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274772
type: SpeciesReference
stoichiometry: 1.0
species: 400960

411399
type: Reaction
kinetic law: 269678
product: 269666
reactant: 269654
reactant: 269641
fast: false
reversible: true

269678
type: KineticLaw
local parameters: 207968
local parameters: 207966
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_4_sbc__slash_PKA_sbo_4_sbc__cplx

207968
type: LocalParameter
units: 257775
value: 2.16E-15

207966
type: LocalParameter
units: 257862
value: 3.999888E-17

269666
type: SpeciesReference
stoichiometry: 1.0
species: 403660

269654
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269641
type: SpeciesReference
stoichiometry: 1.0
species: 405700

401740
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

257927
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

410119
type: Reaction
kinetic law: 266479
product: 266467
reactant: 266455
reactant: 266443
fast: false
reversible: true

266479
type: KineticLaw
local parameters: 207803
local parameters: 207801
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx

207803
type: LocalParameter
units: 257775
value: 7.2E-16

207801
type: LocalParameter
units: 257862
value: 2.011824E-17

266467
type: SpeciesReference
stoichiometry: 1.0
species: 402800

266455
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266443
type: SpeciesReference
stoichiometry: 1.0
species: 405600

409599
type: Reaction
kinetic law: 265221
product: 265209
reactant: 265197
reactant: 265185
fast: false
reversible: true

265221
type: KineticLaw
local parameters: 207738
local parameters: 207736
notes: k1*AMPAR_slash_A845_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx

207738
type: LocalParameter
units: 257775
value: 7.2E-16

207736
type: LocalParameter
units: 257862
value: 1.8106416E-16

265209
type: SpeciesReference
stoichiometry: 1.0
species: 402520

265197
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265185
type: SpeciesReference
stoichiometry: 1.0
species: 405320

404620
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

409459
type: Reaction
kinetic law: 264884
product: 264872
product: 264860
reactant: 264848
fast: false
reversible: false

264884
type: KineticLaw
local parameters: 207719
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_23_sbc__slash_PP2B_sbo_23_sbc__cplx

207719
type: LocalParameter
units: 257775
value: 1.8E-16

264872
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264860
type: SpeciesReference
stoichiometry: 1.0
species: 405400

264848
type: SpeciesReference
stoichiometry: 1.0
species: 402440

409259
type: Reaction
kinetic law: 264401
product: 264389
product: 264377
reactant: 264365
fast: false
reversible: false

264401
type: KineticLaw
local parameters: 207694
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_18_sbc__slash_PP2B_sbo_18_sbc__cplx

207694
type: LocalParameter
units: 257775
value: 1.8E-16

264389
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264377
type: SpeciesReference
stoichiometry: 1.0
species: 405200

264365
type: SpeciesReference
stoichiometry: 1.0
species: 402340

410039
type: Reaction
kinetic law: 266286
product: 266274
reactant: 266262
reactant: 266250
fast: false
reversible: true

266286
type: KineticLaw
local parameters: 207793
local parameters: 207791
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx

207793
type: LocalParameter
units: 257775
value: 7.2E-16

207791
type: LocalParameter
units: 257862
value: 2.011824E-17

266274
type: SpeciesReference
stoichiometry: 1.0
species: 402760

266262
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266250
type: SpeciesReference
stoichiometry: 1.0
species: 405760

412159
type: Reaction
kinetic law: 271514
product: 271502
reactant: 271489
reactant: 271477
fast: false
reversible: true

271514
type: KineticLaw
local parameters: 208064
local parameters: 208062
notes: k1*CaMKII_slash_CaMKII_star__star__star__minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

208064
type: LocalParameter
units: 257775
value: 1.0E-16

208062
type: LocalParameter
units: 257862
value: 2.45142E-17

271502
type: SpeciesReference
stoichiometry: 1.0
species: 404340

271489
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271477
type: SpeciesReference
stoichiometry: 1.0
species: 400980

407339
type: Reaction
kinetic law: 259381
product: 259369
product: 259357
reactant: 259345
notes: This has to be fast, as the activation of PKA by cAMP is also fast. kf was 10
fast: false
reversible: true

259381
type: KineticLaw
local parameters: 207424
local parameters: 207422
notes: kf*PKA_slash_R2C2_minus_cAMP4-kb*PKA_slash_PKA_minus_active*PKA_slash_R2C_minus_cAMP4

207424
type: LocalParameter
units: 257862
value: 1.6199838E-15

207422
type: LocalParameter
units: 257775
value: 5.4E-15

259369
type: SpeciesReference
stoichiometry: 1.0
species: 403100

259357
type: SpeciesReference
stoichiometry: 1.0
species: 403180

259345
type: SpeciesReference
stoichiometry: 1.0
species: 403080

407620
type: Reaction
kinetic law: 260278
product: 260266
reactant: 260254
fast: false
reversible: true

260278
type: KineticLaw
local parameters: 207484
local parameters: 207482
notes: kf*Ca_control_cyt-kb*Ca

207484
type: LocalParameter
units: 257775
value: 9.0E-15

207482
type: LocalParameter
units: 257775
value: 9.0E-15

260266
type: SpeciesReference
stoichiometry: 1.0
species: 400740

260254
type: SpeciesReference
stoichiometry: 1.0
species: 405940

405940
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.08
initial amount: NaN
in compartment: 400680

410419
type: Reaction
kinetic law: 267203
product: 267191
product: 267179
reactant: 267167
fast: false
reversible: false

267203
type: KineticLaw
local parameters: 207839
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_14_sbc__slash_PP2B_sbo_14_sbc__cplx

207839
type: LocalParameter
units: 257775
value: 1.8E-16

267191
type: SpeciesReference
stoichiometry: 1.0
species: 402200

267179
type: SpeciesReference
stoichiometry: 1.0
species: 405560

267167
type: SpeciesReference
stoichiometry: 1.0
species: 402940

410459
type: Reaction
kinetic law: 267300
product: 267288
product: 267276
reactant: 267264
fast: false
reversible: false

267300
type: KineticLaw
local parameters: 207844
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx

207844
type: LocalParameter
units: 257775
value: 1.8E-16

267288
type: SpeciesReference
stoichiometry: 1.0
species: 402200

267276
type: SpeciesReference
stoichiometry: 1.0
species: 405560

267264
type: SpeciesReference
stoichiometry: 1.0
species: 402960

402960
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

406240
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

402240
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

411819
type: Reaction
kinetic law: 270692
product: 270680
product: 270668
reactant: 270656
fast: false
reversible: false

270692
type: KineticLaw
local parameters: 208019
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx

208019
type: LocalParameter
units: 257775
value: 5.4E-16

270680
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270668
type: SpeciesReference
stoichiometry: 1.0
species: 405740

270656
type: SpeciesReference
stoichiometry: 1.0
species: 403860

403360
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

409819
type: Reaction
kinetic law: 265754
product: 265741
product: 265728
reactant: 265716
fast: false
reversible: false

265754
type: KineticLaw
local parameters: 207764
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx

207764
type: LocalParameter
units: 257775
value: 1.8E-16

265741
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265728
type: SpeciesReference
stoichiometry: 1.0
species: 405460

265716
type: SpeciesReference
stoichiometry: 1.0
species: 402620

411619
type: Reaction
kinetic law: 270208
product: 270196
product: 270184
reactant: 270172
fast: false
reversible: false

270208
type: KineticLaw
local parameters: 207994
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx

207994
type: LocalParameter
units: 257775
value: 5.4E-16

270196
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270184
type: SpeciesReference
stoichiometry: 1.0
species: 405780

270172
type: SpeciesReference
stoichiometry: 1.0
species: 403760

403760
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

411659
type: Reaction
kinetic law: 270305
product: 270293
product: 270281
reactant: 270269
fast: false
reversible: false

270305
type: KineticLaw
local parameters: 207999
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx

207999
type: LocalParameter
units: 257775
value: 5.4E-16

270293
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270281
type: SpeciesReference
stoichiometry: 1.0
species: 405720

270269
type: SpeciesReference
stoichiometry: 1.0
species: 403780

409999
type: Reaction
kinetic law: 266190
product: 266178
reactant: 266166
reactant: 266154
fast: false
reversible: true

266190
type: KineticLaw
local parameters: 207788
local parameters: 207786
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_4_sbc__slash_PP2B_sbo_4_sbc__cplx

207788
type: LocalParameter
units: 257775
value: 7.2E-16

207786
type: LocalParameter
units: 257862
value: 2.011824E-17

266178
type: SpeciesReference
stoichiometry: 1.0
species: 402740

266166
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266154
type: SpeciesReference
stoichiometry: 1.0
species: 405760

409619
type: Reaction
kinetic law: 265269
product: 265257
product: 265245
reactant: 265233
fast: false
reversible: false

265269
type: KineticLaw
local parameters: 207739
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_27_sbc__slash_PP2B_sbo_27_sbc__cplx

207739
type: LocalParameter
units: 257775
value: 1.8E-16

265257
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265245
type: SpeciesReference
stoichiometry: 1.0
species: 405360

265233
type: SpeciesReference
stoichiometry: 1.0
species: 402520

407160
type: Reaction
kinetic law: 258725
product: 258713
reactant: 258700
reactant: 258688
notes: Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10
fast: false
reversible: true

258725
type: KineticLaw
local parameters: 207382
local parameters: 207380
notes: kf*CaM_slash_CaM_minus_Ca3_minus_PSD*Ca_minus_PSD-kb*CaM_slash_CaM_minus_Ca4_minus_PSD

207382
type: LocalParameter
units: 257775
value: 1.0E-16

207380
type: LocalParameter
units: 257862
value: 4.65012E-18

258713
type: SpeciesReference
stoichiometry: 1.0
species: 401720

258700
type: SpeciesReference
stoichiometry: 1.0
species: 404180

258688
type: SpeciesReference
stoichiometry: 1.0
species: 401740

411579
type: Reaction
kinetic law: 270111
product: 270098
product: 270086
reactant: 270074
fast: false
reversible: false

270111
type: KineticLaw
local parameters: 207989
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_8_sbc__slash_PKA_sbo_8_sbc__cplx

207989
type: LocalParameter
units: 257775
value: 5.4E-16

270098
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270086
type: SpeciesReference
stoichiometry: 1.0
species: 405780

270074
type: SpeciesReference
stoichiometry: 1.0
species: 403740

411539
type: Reaction
kinetic law: 270014
product: 270002
product: 269990
reactant: 269978
fast: false
reversible: false

270014
type: KineticLaw
local parameters: 207984
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_7_sbc__slash_PKA_sbo_7_sbc__cplx

207984
type: LocalParameter
units: 257775
value: 5.4E-16

270002
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269990
type: SpeciesReference
stoichiometry: 1.0
species: 405600

269978
type: SpeciesReference
stoichiometry: 1.0
species: 403720

408439
type: Reaction
kinetic law: 262356
product: 262344
product: 262332
reactant: 262320
fast: false
reversible: false

262356
type: KineticLaw
local parameters: 207590
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_14_sbc__slash_CaMKII_sbo_14_sbc__cplx

207590
type: LocalParameter
units: 257775
value: 5.0E-18

262344
type: SpeciesReference
stoichiometry: 1.0
species: 406100

262332
type: SpeciesReference
stoichiometry: 1.0
species: 405620

262320
type: SpeciesReference
stoichiometry: 1.0
species: 401440

412559
type: Reaction
kinetic law: 272488
product: 272475
reactant: 272462
reactant: 272449
fast: false
reversible: true

272488
type: KineticLaw
local parameters: 208114
local parameters: 208112
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx

208114
type: LocalParameter
units: 257775
value: 1.4E-17

208112
type: LocalParameter
units: 257862
value: 8.7498E-18

272475
type: SpeciesReference
stoichiometry: 1.0
species: 404540

404540
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

272462
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272449
type: SpeciesReference
stoichiometry: 1.0
species: 405760

412519
type: Reaction
kinetic law: 272383
product: 272371
reactant: 272358
reactant: 272346
fast: false
reversible: true

272383
type: KineticLaw
local parameters: 208109
local parameters: 208107
notes: k1*AMPAR_memb_slash_A831_star_845_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_7_sbc__slash_PP1_sbo_7_sbc__cplx

208109
type: LocalParameter
units: 257775
value: 6.8E-18

208107
type: LocalParameter
units: 257862
value: 8.7498E-18

272371
type: SpeciesReference
stoichiometry: 1.0
species: 404520

272358
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272346
type: SpeciesReference
stoichiometry: 1.0
species: 405600

407979
type: Reaction
kinetic law: 261141
product: 261128
reactant: 261116
reactant: 261104
fast: false
reversible: true

261141
type: KineticLaw
local parameters: 207529
local parameters: 207527
notes: k1*AMPAR_memb_slash_A845_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx

207529
type: LocalParameter
units: 257775
value: 2.0E-17

207527
type: LocalParameter
units: 257862
value: 2.77776E-19

261128
type: SpeciesReference
stoichiometry: 1.0
species: 401200

261116
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261104
type: SpeciesReference
stoichiometry: 1.0
species: 405580

408359
type: Reaction
kinetic law: 262114
product: 262102
reactant: 262090
reactant: 262078
fast: false
reversible: true

262114
type: KineticLaw
local parameters: 207579
local parameters: 207577
notes: k1*AMPAR_memb_slash_A831_star_845_star__B845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx

207579
type: LocalParameter
units: 257775
value: 2.0E-17

207577
type: LocalParameter
units: 257862
value: 2.77776E-19

262102
type: SpeciesReference
stoichiometry: 1.0
species: 401400

262090
type: SpeciesReference
stoichiometry: 1.0
species: 406100

262078
type: SpeciesReference
stoichiometry: 1.0
species: 405760

408199
type: Reaction
kinetic law: 261725
product: 261712
reactant: 261700
reactant: 261688
fast: false
reversible: true

261725
type: KineticLaw
local parameters: 207559
local parameters: 207557
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_8_sbc__slash_CaMKII_sbo_8_sbc__cplx

207559
type: LocalParameter
units: 257775
value: 2.0E-17

207557
type: LocalParameter
units: 257862
value: 2.77776E-19

261712
type: SpeciesReference
stoichiometry: 1.0
species: 401320

261700
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261688
type: SpeciesReference
stoichiometry: 1.0
species: 405780

412899
type: Reaction
kinetic law: 273310
product: 273298
product: 273286
reactant: 273274
fast: false
reversible: false

273310
type: KineticLaw
local parameters: 208157
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_16_sbc__slash_PP1_sbo_16_sbc__cplx

208157
type: LocalParameter
units: 257775
value: 1.7E-18

273298
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273286
type: SpeciesReference
stoichiometry: 1.0
species: 405740

273274
type: SpeciesReference
stoichiometry: 1.0
species: 404700

408159
type: Reaction
kinetic law: 261628
product: 261616
reactant: 261604
reactant: 261592
fast: false
reversible: true

261628
type: KineticLaw
local parameters: 207554
local parameters: 207552
notes: k1*AMPAR_memb_slash_A_B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx

207554
type: LocalParameter
units: 257775
value: 2.0E-17

207552
type: LocalParameter
units: 257862
value: 2.77776E-19

261616
type: SpeciesReference
stoichiometry: 1.0
species: 401300

401300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.80016666666667E-215
initial amount: NaN
in compartment: 400700

261604
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261592
type: SpeciesReference
stoichiometry: 1.0
species: 405500

412859
type: Reaction
kinetic law: 273214
product: 273202
product: 273190
reactant: 273178
fast: false
reversible: false

273214
type: KineticLaw
local parameters: 208152
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_15_sbc__slash_PP1_sbo_15_sbc__cplx

208152
type: LocalParameter
units: 257775
value: 1.7E-18

273202
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273190
type: SpeciesReference
stoichiometry: 1.0
species: 405540

273178
type: SpeciesReference
stoichiometry: 1.0
species: 404680

408739
type: Reaction
kinetic law: 263089
product: 263077
reactant: 263065
reactant: 263053
fast: false
reversible: true

263089
type: KineticLaw
local parameters: 207629
local parameters: 207627
notes: k1*CaMKII_slash_CaMKII_minus_thr286_star__minus_CaM*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

207629
type: LocalParameter
units: 257775
value: 9.0E-16

207627
type: LocalParameter
units: 257862
value: 2.2062942E-16

263077
type: SpeciesReference
stoichiometry: 1.0
species: 402000

263065
type: SpeciesReference
stoichiometry: 1.0
species: 401980

263053
type: SpeciesReference
stoichiometry: 1.0
species: 400800

410139
type: Reaction
kinetic law: 266527
product: 266515
product: 266503
reactant: 266491
fast: false
reversible: false

266527
type: KineticLaw
local parameters: 207804
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_7_sbc__slash_PP2B_sbo_7_sbc__cplx

207804
type: LocalParameter
units: 257775
value: 1.8E-16

266515
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266503
type: SpeciesReference
stoichiometry: 1.0
species: 405520

266491
type: SpeciesReference
stoichiometry: 1.0
species: 402800

408559
type: Reaction
kinetic law: 262654
product: 262641
product: 262628
reactant: 262615
fast: false
reversible: false

262654
type: KineticLaw
local parameters: 207605
notes: k3*CaMKII_slash_tot_minus_CaM_minus_CaMKII_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_slash_CaM_minus_act_minus_286_minus_PSD_cplx

207605
type: LocalParameter
units: 257775
value: 5.0E-18

262641
type: SpeciesReference
stoichiometry: 1.0
species: 406120

262628
type: SpeciesReference
stoichiometry: 1.0
species: 401080

262615
type: SpeciesReference
stoichiometry: 1.0
species: 401500

408660
type: Reaction
kinetic law: 262896
product: 262884
reactant: 262872
reactant: 262860
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true

262896
type: KineticLaw
local parameters: 207619
local parameters: 207617
notes: k1*PP1_PSD_slash_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx

207619
type: LocalParameter
units: 257775
value: 7.50006E-16

207617
type: LocalParameter
units: 257862
value: 6.4584E-18

262884
type: SpeciesReference
stoichiometry: 1.0
species: 401940

262872
type: SpeciesReference
stoichiometry: 1.0
species: 401880

262860
type: SpeciesReference
stoichiometry: 1.0
species: 404220

407199
type: Reaction
kinetic law: 258809
product: 258797
reactant: 258785
notes: This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.
fast: false
reversible: true

258809
type: KineticLaw
local parameters: 207388
local parameters: 207386
notes: kf*CaM_slash_neurogranin_star__PSD-kb*CaM_slash_neurogranin_PSD

207388
type: LocalParameter
units: 257775
value: 0.0

207386
type: LocalParameter
units: 257775
value: 5.0E-20

258797
type: SpeciesReference
stoichiometry: 1.0
species: 401640

258785
type: SpeciesReference
stoichiometry: 1.0
species: 401660

407359
type: Reaction
kinetic law: 259477
product: 259465
reactant: 259453
reactant: 259441
notes: This has to be set to zero for matching the expts in vitro. In vivo we need to consider the inhibition though. kf = 1e-5 kb = 1
fast: false
reversible: true

259477
type: KineticLaw
local parameters: 207430
local parameters: 207428
notes: kf*PKA_slash_PKA_minus_active*PKA_slash_PKA_minus_inhibitor-kb*PKA_slash_inhibited_minus_PKA

207430
type: LocalParameter
units: 257775
value: 9.0E-17

207428
type: LocalParameter
units: 257862
value: 5.399946E-15

259465
type: SpeciesReference
stoichiometry: 1.0
species: 403160

403160
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

259453
type: SpeciesReference
stoichiometry: 1.0
species: 403140

259441
type: SpeciesReference
stoichiometry: 1.0
species: 403180

413239
type: Reaction
kinetic law: 274132
product: 274120
reactant: 274107
reactant: 274095
fast: false
reversible: true

274132
type: KineticLaw
local parameters: 208201
local parameters: 208199
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx

208201
type: LocalParameter
units: 257775
value: 1.4E-17

208199
type: LocalParameter
units: 257862
value: 8.7498E-18

274120
type: SpeciesReference
stoichiometry: 1.0
species: 404880

274107
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274095
type: SpeciesReference
stoichiometry: 1.0
species: 405740

410479
type: Reaction
kinetic law: 267348
product: 267336
reactant: 267324
reactant: 267312
notes: From Seki et al ABB 316(2):673-679
fast: false
reversible: true

267348
type: KineticLaw
local parameters: 207848
local parameters: 207846
notes: k1*CaM_slash_neurogranin_star__PSD*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_neurogranin_PSD_slash_dephosph_neurogranin_PSD_cplx

207848
type: LocalParameter
units: 257775
value: 2.403E-16

207846
type: LocalParameter
units: 257862
value: 3.336012E-18

267336
type: SpeciesReference
stoichiometry: 1.0
species: 402980

267324
type: SpeciesReference
stoichiometry: 1.0
species: 402200

267312
type: SpeciesReference
stoichiometry: 1.0
species: 401660

407159
type: Reaction
kinetic law: 258676
product: 258664
reactant: 258652
reactant: 258640
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true

258676
type: KineticLaw
local parameters: 207379
local parameters: 207377
notes: kf*CaM_slash_CaM_minus_TR2_minus_Ca2_minus_PSD*Ca_minus_PSD-kb*CaM_slash_CaM_minus_Ca3_minus_PSD

207379
type: LocalParameter
units: 257775
value: 1.0E-16

207377
type: LocalParameter
units: 257862
value: 3.6E-17

258664
type: SpeciesReference
stoichiometry: 1.0
species: 401740

258652
type: SpeciesReference
stoichiometry: 1.0
species: 404180

258640
type: SpeciesReference
stoichiometry: 1.0
species: 401760

410819
type: Reaction
kinetic law: 268225
product: 268213
reactant: 268200
reactant: 268188
fast: false
reversible: true

268225
type: KineticLaw
local parameters: 207893
local parameters: 207891
notes: k1*AMPAR_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx

207893
type: LocalParameter
units: 257775
value: 2.16E-15

207891
type: LocalParameter
units: 257862
value: 3.5998992E-16

268213
type: SpeciesReference
stoichiometry: 1.0
species: 403360

268200
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268188
type: SpeciesReference
stoichiometry: 1.0
species: 405200

410959
type: Reaction
kinetic law: 268562
product: 268550
product: 268538
reactant: 268526
fast: false
reversible: false

268562
type: KineticLaw
local parameters: 207909
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_24_sbc__slash_PKA_sbo_24_sbc__cplx

207909
type: LocalParameter
units: 257775
value: 5.4E-16

268550
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268538
type: SpeciesReference
stoichiometry: 1.0
species: 405280

268526
type: SpeciesReference
stoichiometry: 1.0
species: 403420

410439
type: Reaction
kinetic law: 267252
product: 267240
reactant: 267227
reactant: 267215
fast: false
reversible: true

267252
type: KineticLaw
local parameters: 207843
local parameters: 207841
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_15_sbc__slash_PP2B_sbo_15_sbc__cplx

207843
type: LocalParameter
units: 257775
value: 7.2E-16

207841
type: LocalParameter
units: 257862
value: 2.011824E-17

267240
type: SpeciesReference
stoichiometry: 1.0
species: 402960

267227
type: SpeciesReference
stoichiometry: 1.0
species: 402200

267215
type: SpeciesReference
stoichiometry: 1.0
species: 405740

410999
type: Reaction
kinetic law: 268658
product: 268646
product: 268634
reactant: 268622
fast: false
reversible: false

268658
type: KineticLaw
local parameters: 207914
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx

207914
type: LocalParameter
units: 257775
value: 5.4E-16

268646
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268634
type: SpeciesReference
stoichiometry: 1.0
species: 405300

268622
type: SpeciesReference
stoichiometry: 1.0
species: 403440

403440
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

412259
type: Reaction
kinetic law: 271756
product: 271744
product: 271732
reactant: 271719
fast: false
reversible: false

271756
type: KineticLaw
local parameters: 208075
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_slash_PP1_cplx

208075
type: LocalParameter
units: 257775
value: 1.7E-18

271744
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271732
type: SpeciesReference
stoichiometry: 1.0
species: 405640

271719
type: SpeciesReference
stoichiometry: 1.0
species: 404380

408919
type: Reaction
kinetic law: 263528
product: 263516
product: 263504
reactant: 263492
fast: false
reversible: false

263528
type: KineticLaw
local parameters: 207649
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305a_slash_Deph_minus_thr305a_cplx

207649
type: LocalParameter
units: 257775
value: 2.25E-16

263516
type: SpeciesReference
stoichiometry: 1.0
species: 401980

263504
type: SpeciesReference
stoichiometry: 1.0
species: 400760

263492
type: SpeciesReference
stoichiometry: 1.0
species: 402080

411679
type: Reaction
kinetic law: 270353
product: 270341
reactant: 270329
reactant: 270317
fast: false
reversible: true

270353
type: KineticLaw
local parameters: 208003
local parameters: 208001
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_11_sbc__slash_PKA_sbo_11_sbc__cplx

208003
type: LocalParameter
units: 257775
value: 2.16E-15

208001
type: LocalParameter
units: 257862
value: 3.999888E-17

270341
type: SpeciesReference
stoichiometry: 1.0
species: 403800

270329
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270317
type: SpeciesReference
stoichiometry: 1.0
species: 405540

411639
type: Reaction
kinetic law: 270257
product: 270244
reactant: 270232
reactant: 270220
fast: false
reversible: true

270257
type: KineticLaw
local parameters: 207998
local parameters: 207996
notes: k1*AMPAR_memb_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_10_sbc__slash_PKA_sbo_10_sbc__cplx

207998
type: LocalParameter
units: 257775
value: 2.16E-15

207996
type: LocalParameter
units: 257862
value: 3.999888E-17

270244
type: SpeciesReference
stoichiometry: 1.0
species: 403780

270232
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270220
type: SpeciesReference
stoichiometry: 1.0
species: 405540

407719
type: Reaction
kinetic law: 260510
product: 260498
product: 260486
reactant: 260474
fast: false
reversible: false

260510
type: KineticLaw
local parameters: 207496
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx

207496
type: LocalParameter
units: 257775
value: 4.5E-17

260498
type: SpeciesReference
stoichiometry: 1.0
species: 405980

260486
type: SpeciesReference
stoichiometry: 1.0
species: 400800

260474
type: SpeciesReference
stoichiometry: 1.0
species: 400880

413059
type: Reaction
kinetic law: 273695
product: 273683
product: 273671
reactant: 273659
fast: false
reversible: false

273695
type: KineticLaw
local parameters: 208177
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_20_sbc__slash_PP1_sbo_20_sbc__cplx

208177
type: LocalParameter
units: 257775
value: 3.5E-18

273683
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273671
type: SpeciesReference
stoichiometry: 1.0
species: 405640

273659
type: SpeciesReference
stoichiometry: 1.0
species: 404780

407499
type: Reaction
kinetic law: 260023
product: 260011
reactant: 259999
reactant: 259987
fast: false
reversible: true

260023
type: KineticLaw
local parameters: 207466
local parameters: 207464
notes: kf*AMPAR_slash_A835_star_845_star__B835_star_845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A835_star_845_star__B835_star_845_star_

207466
type: LocalParameter
units: 257775
value: 8.0E-20

207464
type: LocalParameter
units: 257862
value: 1.08E-19

260011
type: SpeciesReference
stoichiometry: 1.0
species: 405800

259999
type: SpeciesReference
stoichiometry: 1.0
species: 405840

259987
type: SpeciesReference
stoichiometry: 1.0
species: 405340

409639
type: Reaction
kinetic law: 265317
product: 265305
reactant: 265293
reactant: 265281
fast: false
reversible: true

265317
type: KineticLaw
local parameters: 207743
local parameters: 207741
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx

207743
type: LocalParameter
units: 257775
value: 7.2E-16

207741
type: LocalParameter
units: 257862
value: 1.8106416E-16

265305
type: SpeciesReference
stoichiometry: 1.0
species: 402540

265293
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265281
type: SpeciesReference
stoichiometry: 1.0
species: 405340

412079
type: Reaction
kinetic law: 271321
product: 271309
reactant: 271297
reactant: 271285
fast: false
reversible: true

271321
type: KineticLaw
local parameters: 208054
local parameters: 208052
notes: k1*CaMKII_slash_CaMKII_minus_thr286_minus_CaM_minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

208054
type: LocalParameter
units: 257775
value: 1.0E-16

208052
type: LocalParameter
units: 257862
value: 6.2502E-17

271309
type: SpeciesReference
stoichiometry: 1.0
species: 404300

271297
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271285
type: SpeciesReference
stoichiometry: 1.0
species: 401080

407519
type: Reaction
kinetic law: 260071
product: 260059
reactant: 260047
reactant: 260035
fast: false
reversible: true

260071
type: KineticLaw
local parameters: 207469
local parameters: 207467
notes: kf*AMPAR_slash_A845_star__B831_star_845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A845_star__B831_star_845_star_

207469
type: LocalParameter
units: 257775
value: 8.0E-20

207467
type: LocalParameter
units: 257862
value: 1.08E-19

260059
type: SpeciesReference
stoichiometry: 1.0
species: 405780

260047
type: SpeciesReference
stoichiometry: 1.0
species: 405840

260035
type: SpeciesReference
stoichiometry: 1.0
species: 405320

408299
type: Reaction
kinetic law: 261968
product: 261956
product: 261944
reactant: 261932
fast: false
reversible: false

261968
type: KineticLaw
local parameters: 207570
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx

207570
type: LocalParameter
units: 257775
value: 5.0E-18

261956
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261944
type: SpeciesReference
stoichiometry: 1.0
species: 405620

261932
type: SpeciesReference
stoichiometry: 1.0
species: 401360

408459
type: Reaction
kinetic law: 262405
product: 262393
reactant: 262380
reactant: 262368
fast: false
reversible: true

262405
type: KineticLaw
local parameters: 207594
local parameters: 207592
notes: k1*AMPAR_memb_slash_A831_star__B*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_15_sbc__slash_CaMKII_sbo_15_sbc__cplx

207594
type: LocalParameter
units: 257775
value: 2.0E-17

207592
type: LocalParameter
units: 257862
value: 2.77776E-19

262393
type: SpeciesReference
stoichiometry: 1.0
species: 401460

262380
type: SpeciesReference
stoichiometry: 1.0
species: 406100

262368
type: SpeciesReference
stoichiometry: 1.0
species: 405520

413399
type: Reaction
kinetic law: 274518
product: 274506
reactant: 274494
reactant: 274482
fast: false
reversible: true

274518
type: KineticLaw
local parameters: 208221
local parameters: 208219
notes: k1*AMPAR_memb_slash_A831_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx

208221
type: LocalParameter
units: 257775
value: 1.4E-17

208219
type: LocalParameter
units: 257862
value: 8.7498E-18

274506
type: SpeciesReference
stoichiometry: 1.0
species: 404960

404960
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

274494
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274482
type: SpeciesReference
stoichiometry: 1.0
species: 405740

408259
type: Reaction
kinetic law: 261869
product: 261857
product: 261845
reactant: 261833
fast: false
reversible: false

261869
type: KineticLaw
local parameters: 207565
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_9_sbc__slash_CaMKII_sbo_9_sbc__cplx

207565
type: LocalParameter
units: 257775
value: 5.0E-18

261857
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261845
type: SpeciesReference
stoichiometry: 1.0
species: 405740

261833
type: SpeciesReference
stoichiometry: 1.0
species: 401340

406040
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: 400680

412659
type: Reaction
kinetic law: 272733
product: 272721
product: 272709
reactant: 272697
fast: false
reversible: false

272733
type: KineticLaw
local parameters: 208126
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_10_sbc__slash_PP1_sbo_10_sbc__cplx

208126
type: LocalParameter
units: 257775
value: 3.5E-18

272721
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272709
type: SpeciesReference
stoichiometry: 1.0
species: 405580

272697
type: SpeciesReference
stoichiometry: 1.0
species: 404580

407859
type: Reaction
kinetic law: 260850
product: 260838
reactant: 260825
reactant: 260813
fast: false
reversible: true

260850
type: KineticLaw
local parameters: 207514
local parameters: 207512
notes: k1*CaMKII_slash_CaMKII_minus_CaM_minus_PSD*CaMKII_slash_tot_minus_auto_minus_PSD-k2*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx

207514
type: LocalParameter
units: 257775
value: 2.0E-17

207512
type: LocalParameter
units: 257862
value: 1.99998E-19

260838
type: SpeciesReference
stoichiometry: 1.0
species: 401120

401120
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

260825
type: SpeciesReference
stoichiometry: 1.0
species: 406060

260813
type: SpeciesReference
stoichiometry: 1.0
species: 401060

408839
type: Reaction
kinetic law: 263332
product: 263320
product: 263308
reactant: 263296
fast: false
reversible: false

263332
type: KineticLaw
local parameters: 207640
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

207640
type: LocalParameter
units: 257775
value: 2.25E-16

263320
type: SpeciesReference
stoichiometry: 1.0
species: 401980

263308
type: SpeciesReference
stoichiometry: 1.0
species: 400840

263296
type: SpeciesReference
stoichiometry: 1.0
species: 402040

413419
type: Reaction
kinetic law: 274567
product: 274555
product: 274543
reactant: 274531
fast: false
reversible: false

274567
type: KineticLaw
local parameters: 208222
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_29_sbc__slash_PP1_sbo_29_sbc__cplx

208222
type: LocalParameter
units: 257775
value: 3.5E-18

274555
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274543
type: SpeciesReference
stoichiometry: 1.0
species: 405700

274531
type: SpeciesReference
stoichiometry: 1.0
species: 404960

408179
type: Reaction
kinetic law: 261676
product: 261664
product: 261652
reactant: 261640
fast: false
reversible: false

261676
type: KineticLaw
local parameters: 207555
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_7_sbc__slash_CaMKII_sbo_7_sbc__cplx

207555
type: LocalParameter
units: 257775
value: 5.0E-18

261664
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261652
type: SpeciesReference
stoichiometry: 1.0
species: 405540

261640
type: SpeciesReference
stoichiometry: 1.0
species: 401300

411259
type: Reaction
kinetic law: 269338
product: 269326
product: 269314
reactant: 269301
fast: false
reversible: false

269338
type: KineticLaw
local parameters: 207949
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_slash_PKA_cplx

207949
type: LocalParameter
units: 257775
value: 5.4E-16

269326
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269314
type: SpeciesReference
stoichiometry: 1.0
species: 405680

269301
type: SpeciesReference
stoichiometry: 1.0
species: 403580

406920
type: Reaction
kinetic law: 258121
product: 258109
product: 258096
reactant: 258084
notes: Rates set by the translocation experiments of Shen and Meyer, Science 1999.
fast: false
reversible: true

258121
type: KineticLaw
local parameters: 207343
local parameters: 207341
notes: kf*CaMKII_slash_CaMKII_minus_PSD-kb*CaMKII_slash_CaMKII*CaMKII_slash_NMDAR

207343
type: LocalParameter
units: 257862
value: 5.4E-21

207341
type: LocalParameter
units: 257775
value: 3.0E-18

258109
type: SpeciesReference
stoichiometry: 1.0
species: 401020

258096
type: SpeciesReference
stoichiometry: 1.0
species: 400760

258084
type: SpeciesReference
stoichiometry: 1.0
species: 401000

409319
type: Reaction
kinetic law: 264548
product: 264535
reactant: 264523
reactant: 264510
fast: false
reversible: true

264548
type: KineticLaw
local parameters: 207703
local parameters: 207701
notes: k1*AMPAR_slash_A831_star_845_star__B831_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx

207703
type: LocalParameter
units: 257775
value: 7.2E-16

207701
type: LocalParameter
units: 257862
value: 1.8106416E-16

264535
type: SpeciesReference
stoichiometry: 1.0
species: 402380

402380
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

264523
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264510
type: SpeciesReference
stoichiometry: 1.0
species: 405460

408759
type: Reaction
kinetic law: 263137
product: 263125
product: 263113
reactant: 263101
fast: false
reversible: false

263137
type: KineticLaw
local parameters: 207630
notes: k3*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

207630
type: LocalParameter
units: 257775
value: 2.25E-16

263125
type: SpeciesReference
stoichiometry: 1.0
species: 401980

263113
type: SpeciesReference
stoichiometry: 1.0
species: 400780

263101
type: SpeciesReference
stoichiometry: 1.0
species: 402000

407679
type: Reaction
kinetic law: 260413
product: 260401
product: 260389
reactant: 260377
fast: false
reversible: false

260413
type: KineticLaw
local parameters: 207491
notes: k3*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_305_slash_CaM_act_305_cplx

207491
type: LocalParameter
units: 257775
value: 5.4E-16

260401
type: SpeciesReference
stoichiometry: 1.0
species: 405980

260389
type: SpeciesReference
stoichiometry: 1.0
species: 400820

260377
type: SpeciesReference
stoichiometry: 1.0
species: 400860

413719
type: Reaction
kinetic law: 275302
product: 275290
reactant: 275278
reactant: 275266
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

275302
type: KineticLaw
local parameters: 208261
local parameters: 208259
notes: k1*CaM_slash_neurogranin_minus_CaM_PSD*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx

208261
type: LocalParameter
units: 257775
value: 1.26E-16

208259
type: LocalParameter
units: 257862
value: 6.11982E-19

275290
type: SpeciesReference
stoichiometry: 1.0
species: 405140

275278
type: SpeciesReference
stoichiometry: 1.0
species: 405040

275266
type: SpeciesReference
stoichiometry: 1.0
species: 401620

411079
type: Reaction
kinetic law: 268851
product: 268839
product: 268826
reactant: 268814
fast: false
reversible: false

268851
type: KineticLaw
local parameters: 207924
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_27_sbc__slash_PKA_sbo_27_sbc__cplx

207924
type: LocalParameter
units: 257775
value: 5.4E-16

268839
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268826
type: SpeciesReference
stoichiometry: 1.0
species: 405340

268814
type: SpeciesReference
stoichiometry: 1.0
species: 403480

403260
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

406220
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

409079
type: Reaction
kinetic law: 263965
product: 263952
reactant: 263940
reactant: 263928
fast: false
reversible: true

263965
type: KineticLaw
local parameters: 207673
local parameters: 207671
notes: k1*PP1_slash_PP1_minus_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx

207673
type: LocalParameter
units: 257775
value: 1.224E-16

207671
type: LocalParameter
units: 257862
value: 3.0779838E-17

263952
type: SpeciesReference
stoichiometry: 1.0
species: 402260

263940
type: SpeciesReference
stoichiometry: 1.0
species: 402200

263928
type: SpeciesReference
stoichiometry: 1.0
species: 401840

409799
type: Reaction
kinetic law: 265704
product: 265692
reactant: 265680
reactant: 265668
fast: false
reversible: true

265704
type: KineticLaw
local parameters: 207763
local parameters: 207761
notes: k1*AMPAR_slash_A835_star_845_star__B835_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_32_sbc__slash_PP2B_sbo_32_sbc__cplx

207763
type: LocalParameter
units: 257775
value: 7.2E-16

207761
type: LocalParameter
units: 257862
value: 1.8106416E-16

265692
type: SpeciesReference
stoichiometry: 1.0
species: 402620

265680
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265668
type: SpeciesReference
stoichiometry: 1.0
species: 405340

409039
type: Reaction
kinetic law: 263866
product: 263854
reactant: 263842
reactant: 263830
fast: false
reversible: true

263866
type: KineticLaw
local parameters: 207668
local parameters: 207666
notes: k1*PP1_slash_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx

207668
type: LocalParameter
units: 257775
value: 1.224E-16

207666
type: LocalParameter
units: 257862
value: 3.0779838E-17

263854
type: SpeciesReference
stoichiometry: 1.0
species: 402240

263842
type: SpeciesReference
stoichiometry: 1.0
species: 402200

263830
type: SpeciesReference
stoichiometry: 1.0
species: 401820

408579
type: Reaction
kinetic law: 262704
product: 262692
reactant: 262680
reactant: 262667
notes: PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
fast: false
reversible: true

262704
type: KineticLaw
local parameters: 207609
local parameters: 207607
notes: k1*PP1_slash_I1_star_*PP1_slash_PP2A-k2*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_slash_PP2A_minus_dephosph_minus_I1_cplx

207609
type: LocalParameter
units: 257775
value: 7.50006E-16

207607
type: LocalParameter
units: 257862
value: 5.81256E-17

262692
type: SpeciesReference
stoichiometry: 1.0
species: 401900

262680
type: SpeciesReference
stoichiometry: 1.0
species: 401880

262667
type: SpeciesReference
stoichiometry: 1.0
species: 401820

412359
type: Reaction
kinetic law: 271996
product: 271984
reactant: 271972
reactant: 271960
fast: false
reversible: true

271996
type: KineticLaw
local parameters: 208089
local parameters: 208087
notes: k1*AMPAR_memb_slash_A_B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx

208089
type: LocalParameter
units: 257775
value: 6.8E-18

208087
type: LocalParameter
units: 257862
value: 8.7498E-18

271984
type: SpeciesReference
stoichiometry: 1.0
species: 404440

404440
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

271972
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271960
type: SpeciesReference
stoichiometry: 1.0
species: 405640

413259
type: Reaction
kinetic law: 274180
product: 274168
product: 274156
reactant: 274144
fast: false
reversible: false

274180
type: KineticLaw
local parameters: 208202
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_25_sbc__slash_PP1_sbo_25_sbc__cplx

208202
type: LocalParameter
units: 257775
value: 3.5E-18

274168
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274156
type: SpeciesReference
stoichiometry: 1.0
species: 405720

274144
type: SpeciesReference
stoichiometry: 1.0
species: 404880

410839
type: Reaction
kinetic law: 268273
product: 268261
product: 268249
reactant: 268237
fast: false
reversible: false

268273
type: KineticLaw
local parameters: 207894
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_21_sbc__slash_PKA_sbo_21_sbc__cplx

207894
type: LocalParameter
units: 257775
value: 5.4E-16

268261
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268249
type: SpeciesReference
stoichiometry: 1.0
species: 405480

268237
type: SpeciesReference
stoichiometry: 1.0
species: 403360

410979
type: Reaction
kinetic law: 268610
product: 268598
reactant: 268586
reactant: 268574
fast: false
reversible: true

268610
type: KineticLaw
local parameters: 207913
local parameters: 207911
notes: k1*AMPAR_slash_A831_star__B845_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_25_sbc__slash_PKA_sbo_25_sbc__cplx

207913
type: LocalParameter
units: 257775
value: 2.16E-15

207911
type: LocalParameter
units: 257862
value: 3.5998992E-16

268598
type: SpeciesReference
stoichiometry: 1.0
species: 403440

268586
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268574
type: SpeciesReference
stoichiometry: 1.0
species: 405480

412279
type: Reaction
kinetic law: 271804
product: 271792
reactant: 271780
reactant: 271768
fast: false
reversible: true

271804
type: KineticLaw
local parameters: 208079
local parameters: 208077
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_1_sbc__slash_PP1_sbo_1_sbc__cplx

208079
type: LocalParameter
units: 257775
value: 6.8E-18

208077
type: LocalParameter
units: 257862
value: 8.7498E-18

271792
type: SpeciesReference
stoichiometry: 1.0
species: 404400

271780
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271768
type: SpeciesReference
stoichiometry: 1.0
species: 405680

410639
type: Reaction
kinetic law: 267744
product: 267732
reactant: 267720
reactant: 267708
fast: false
reversible: true

267744
type: KineticLaw
local parameters: 207868
local parameters: 207866
notes: k1*AMPAR_slash_A_B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx

207868
type: LocalParameter
units: 257775
value: 2.16E-15

207866
type: LocalParameter
units: 257862
value: 3.5998992E-16

267732
type: SpeciesReference
stoichiometry: 1.0
species: 403260

267720
type: SpeciesReference
stoichiometry: 1.0
species: 403180

267708
type: SpeciesReference
stoichiometry: 1.0
species: 405180

406380
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

408939
type: Reaction
kinetic law: 263576
product: 263564
reactant: 263552
reactant: 263540
notes: The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
fast: false
reversible: true

263576
type: KineticLaw
local parameters: 207653
local parameters: 207651
notes: k1*PP1_slash_I1_star_*PP2B_slash_CaNAB_minus_Ca4-k2*PP2B_slash_CaNAB_minus_Ca4_slash_dephosph_inhib1_noCaM_slash_dephosph_inhib1_noCaM_cplx

207653
type: LocalParameter
units: 257775
value: 1.224E-17

207651
type: LocalParameter
units: 257862
value: 3.0779838E-18

263564
type: SpeciesReference
stoichiometry: 1.0
species: 402160

263552
type: SpeciesReference
stoichiometry: 1.0
species: 402140

263540
type: SpeciesReference
stoichiometry: 1.0
species: 401820

410679
type: Reaction
kinetic law: 267888
product: 267876
product: 267864
reactant: 267852
fast: false
reversible: false

267888
type: KineticLaw
local parameters: 207874
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx

207874
type: LocalParameter
units: 257775
value: 5.4E-16

267876
type: SpeciesReference
stoichiometry: 1.0
species: 403180

267864
type: SpeciesReference
stoichiometry: 1.0
species: 405240

267852
type: SpeciesReference
stoichiometry: 1.0
species: 403280

412179
type: Reaction
kinetic law: 271562
product: 271550
product: 271538
reactant: 271526
fast: false
reversible: false

271562
type: KineticLaw
local parameters: 208065
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr305_slash_Deph_minus_thr305_cplx

208065
type: LocalParameter
units: 257775
value: 2.5E-17

271550
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271538
type: SpeciesReference
stoichiometry: 1.0
species: 401040

271526
type: SpeciesReference
stoichiometry: 1.0
species: 404340

411739
type: Reaction
kinetic law: 270498
product: 270486
product: 270474
reactant: 270462
fast: false
reversible: false

270498
type: KineticLaw
local parameters: 208009
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_12_sbc__slash_PKA_sbo_12_sbc__cplx

208009
type: LocalParameter
units: 257775
value: 5.4E-16

270486
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270474
type: SpeciesReference
stoichiometry: 1.0
species: 405800

270462
type: SpeciesReference
stoichiometry: 1.0
species: 403820

407360
type: Reaction
kinetic law: 259525
product: 259513
reactant: 259501
reactant: 259489
notes: Half-max at 20 nM CaM (Tang et al JBC 266:13 8595-8603 1991 kb/kf = 20 nM = 12000 #/cell so kf = kb/12000 = kb * 8.333e-5
fast: false
reversible: true

259525
type: KineticLaw
local parameters: 207433
local parameters: 207431
notes: kf*CaM_slash_CaM_minus_Ca4*AC_slash_AC1-kb*AC_slash_AC1_minus_CaM

207433
type: LocalParameter
units: 257775
value: 9.0E-17

207431
type: LocalParameter
units: 257862
value: 4.4999712E-15

259513
type: SpeciesReference
stoichiometry: 1.0
species: 403900

403900
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

259501
type: SpeciesReference
stoichiometry: 1.0
species: 402640

402640
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0740740740740741
initial amount: NaN
in compartment: 400680

259489
type: SpeciesReference
stoichiometry: 1.0
species: 401780

411779
type: Reaction
kinetic law: 270595
product: 270583
product: 270570
reactant: 270558
fast: false
reversible: false

270595
type: KineticLaw
local parameters: 208014
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx

208014
type: LocalParameter
units: 257775
value: 5.4E-16

270583
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270570
type: SpeciesReference
stoichiometry: 1.0
species: 405800

270558
type: SpeciesReference
stoichiometry: 1.0
species: 403840

413079
type: Reaction
kinetic law: 273744
product: 273731
reactant: 273719
reactant: 273707
fast: false
reversible: true

273744
type: KineticLaw
local parameters: 208181
local parameters: 208179
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_21_sbc__slash_PP1_sbo_21_sbc__cplx

208181
type: LocalParameter
units: 257775
value: 1.4E-17

208179
type: LocalParameter
units: 257862
value: 8.7498E-18

273731
type: SpeciesReference
stoichiometry: 1.0
species: 404800

273719
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273707
type: SpeciesReference
stoichiometry: 1.0
species: 405780

412719
type: Reaction
kinetic law: 272878
product: 272866
reactant: 272854
reactant: 272842
fast: false
reversible: true

272878
type: KineticLaw
local parameters: 208135
local parameters: 208133
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx

208135
type: LocalParameter
units: 257775
value: 6.8E-18

208133
type: LocalParameter
units: 257862
value: 8.7498E-18

272866
type: SpeciesReference
stoichiometry: 1.0
species: 404620

272854
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272842
type: SpeciesReference
stoichiometry: 1.0
species: 405780

412759
type: Reaction
kinetic law: 272974
product: 272962
reactant: 272950
reactant: 272938
fast: false
reversible: true

272974
type: KineticLaw
local parameters: 208140
local parameters: 208138
notes: k1*AMPAR_memb_slash_A845_star__B831_star_845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx

208140
type: LocalParameter
units: 257775
value: 6.8E-18

208138
type: LocalParameter
units: 257862
value: 8.7498E-18

272962
type: SpeciesReference
stoichiometry: 1.0
species: 404640

272950
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272938
type: SpeciesReference
stoichiometry: 1.0
species: 405780

407959
type: Reaction
kinetic law: 261092
product: 261080
product: 261068
reactant: 261056
fast: false
reversible: false

261092
type: KineticLaw
local parameters: 207525
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_1_sbc__slash_CaMKII_sbo_1_sbc__cplx

207525
type: LocalParameter
units: 257775
value: 5.0E-18

261080
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261068
type: SpeciesReference
stoichiometry: 1.0
species: 405700

261056
type: SpeciesReference
stoichiometry: 1.0
species: 401180

412099
type: Reaction
kinetic law: 271369
product: 271357
product: 271345
reactant: 271333
fast: false
reversible: false

271369
type: KineticLaw
local parameters: 208055
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286_slash_Deph_minus_thr286_cplx

208055
type: LocalParameter
units: 257775
value: 2.5E-17

271357
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271345
type: SpeciesReference
stoichiometry: 1.0
species: 401060

271333
type: SpeciesReference
stoichiometry: 1.0
species: 404300

407539
type: Reaction
kinetic law: 260119
product: 260107
reactant: 260095
reactant: 260083
fast: false
reversible: true

260119
type: KineticLaw
local parameters: 207472
local parameters: 207470
notes: kf*AMPAR_slash_A831_star_845_star__B845_star_*AMPAR_memb_slash_Anchor-kb*AMPAR_memb_slash_A831_star_845_star__B845_star_

207472
type: LocalParameter
units: 257775
value: 8.0E-20

207470
type: LocalParameter
units: 257862
value: 1.08E-19

260107
type: SpeciesReference
stoichiometry: 1.0
species: 405760

260095
type: SpeciesReference
stoichiometry: 1.0
species: 405840

260083
type: SpeciesReference
stoichiometry: 1.0
species: 405300

407000
type: Reaction
kinetic law: 258302
product: 258290
product: 258278
reactant: 258266
fast: false
reversible: true

258302
type: KineticLaw
local parameters: 207355
local parameters: 207353
notes: kf*CaMKII_slash_CaMKII_minus_CaM_minus_PSD-kb*CaM_slash_CaM_minus_Ca4_minus_PSD*CaMKII_slash_CaMKII_minus_PSD

207355
type: LocalParameter
units: 257862
value: 0.0

207353
type: LocalParameter
units: 257775
value: 5.0E-17

258290
type: SpeciesReference
stoichiometry: 1.0
species: 401000

258278
type: SpeciesReference
stoichiometry: 1.0
species: 401720

258266
type: SpeciesReference
stoichiometry: 1.0
species: 401060

408279
type: Reaction
kinetic law: 261919
product: 261907
reactant: 261894
reactant: 261882
fast: false
reversible: true

261919
type: KineticLaw
local parameters: 207569
local parameters: 207567
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*CaMKII_slash_actCaMKII_minus_PSD-k2*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_10_sbc__slash_CaMKII_sbo_10_sbc__cplx

207569
type: LocalParameter
units: 257775
value: 2.0E-17

207567
type: LocalParameter
units: 257862
value: 2.77776E-19

261907
type: SpeciesReference
stoichiometry: 1.0
species: 401360

261894
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261882
type: SpeciesReference
stoichiometry: 1.0
species: 405660

412679
type: Reaction
kinetic law: 272782
product: 272770
reactant: 272757
reactant: 272745
fast: false
reversible: true

272782
type: KineticLaw
local parameters: 208130
local parameters: 208128
notes: k1*AMPAR_memb_slash_A831_star__B*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_11_sbc__slash_PP1_sbo_11_sbc__cplx

208130
type: LocalParameter
units: 257775
value: 1.4E-17

208128
type: LocalParameter
units: 257862
value: 8.7498E-18

272770
type: SpeciesReference
stoichiometry: 1.0
species: 404600

272757
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272745
type: SpeciesReference
stoichiometry: 1.0
species: 405520

412479
type: Reaction
kinetic law: 272286
product: 272274
reactant: 272261
reactant: 272249
fast: false
reversible: true

272286
type: KineticLaw
local parameters: 208104
local parameters: 208102
notes: k1*AMPAR_memb_slash_A831_star__B845_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx

208104
type: LocalParameter
units: 257775
value: 6.8E-18

208102
type: LocalParameter
units: 257862
value: 8.7498E-18

272274
type: SpeciesReference
stoichiometry: 1.0
species: 404500

272261
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272249
type: SpeciesReference
stoichiometry: 1.0
species: 405700

407879
type: Reaction
kinetic law: 260899
product: 260886
product: 260874
reactant: 260862
fast: false
reversible: false

260899
type: KineticLaw
local parameters: 207515
notes: k3*CaMKII_slash_tot_minus_auto_minus_PSD_slash_auton_minus_286_minus_PSD_slash_auton_minus_286_minus_PSD_cplx

207515
type: LocalParameter
units: 257775
value: 5.0E-18

260886
type: SpeciesReference
stoichiometry: 1.0
species: 406060

260874
type: SpeciesReference
stoichiometry: 1.0
species: 401080

260862
type: SpeciesReference
stoichiometry: 1.0
species: 401120

413439
type: Reaction
kinetic law: 274615
product: 274603
reactant: 274591
reactant: 274579
fast: false
reversible: true

274615
type: KineticLaw
local parameters: 208226
local parameters: 208224
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_30_sbc__slash_PP1_sbo_30_sbc__cplx

208226
type: LocalParameter
units: 257775
value: 1.4E-17

208224
type: LocalParameter
units: 257862
value: 8.7498E-18

274603
type: SpeciesReference
stoichiometry: 1.0
species: 404980

274591
type: SpeciesReference
stoichiometry: 1.0
species: 404280

274579
type: SpeciesReference
stoichiometry: 1.0
species: 405620

408859
type: Reaction
kinetic law: 263381
product: 263368
reactant: 263356
reactant: 263344
fast: false
reversible: true

263381
type: KineticLaw
local parameters: 207643
local parameters: 207642
notes: k1*CaMKII_slash_CaMKII_star__star__star_*PP1_slash_PP1_minus_active-k2*PP1_slash_PP1_minus_active_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

207643
type: LocalParameter
units: 257775
value: 9.0E-16

207642
type: LocalParameter
units: 257862
value: 2.2062942E-16

263368
type: SpeciesReference
stoichiometry: 1.0
species: 402060

263356
type: SpeciesReference
stoichiometry: 1.0
species: 401980

263344
type: SpeciesReference
stoichiometry: 1.0
species: 400820

411279
type: Reaction
kinetic law: 269387
product: 269374
reactant: 269362
reactant: 269350
fast: false
reversible: true

269387
type: KineticLaw
local parameters: 207953
local parameters: 207951
notes: k1*AMPAR_memb_slash_A845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_1_sbc__slash_PKA_sbo_1_sbc__cplx

207953
type: LocalParameter
units: 257775
value: 2.16E-15

207951
type: LocalParameter
units: 257862
value: 3.999888E-17

269374
type: SpeciesReference
stoichiometry: 1.0
species: 403600

269362
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269350
type: SpeciesReference
stoichiometry: 1.0
species: 405580

407999
type: Reaction
kinetic law: 261190
product: 261178
product: 261166
reactant: 261154
fast: false
reversible: false

261190
type: KineticLaw
local parameters: 207530
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_2_sbc__slash_CaMKII_sbo_2_sbc__cplx

207530
type: LocalParameter
units: 257775
value: 5.0E-18

261178
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261166
type: SpeciesReference
stoichiometry: 1.0
species: 405600

261154
type: SpeciesReference
stoichiometry: 1.0
species: 401200

409339
type: Reaction
kinetic law: 264596
product: 264584
product: 264572
reactant: 264560
fast: false
reversible: false

264596
type: KineticLaw
local parameters: 207704
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_20_sbc__slash_PP2B_sbo_20_sbc__cplx

207704
type: LocalParameter
units: 257775
value: 1.8E-16

264584
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264572
type: SpeciesReference
stoichiometry: 1.0
species: 405440

264560
type: SpeciesReference
stoichiometry: 1.0
species: 402380

406940
type: Reaction
kinetic law: 258169
product: 258157
reactant: 258145
reactant: 258133
notes: Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers
fast: false
reversible: true

258169
type: KineticLaw
local parameters: 207346
local parameters: 207344
notes: kf*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_NMDAR-kb*CaMKII_slash_CaMKII_minus_CaM_minus_PSD

207346
type: LocalParameter
units: 257775
value: 0.0

207344
type: LocalParameter
units: 257862
value: 1.08E-20

258157
type: SpeciesReference
stoichiometry: 1.0
species: 401060

258145
type: SpeciesReference
stoichiometry: 1.0
species: 401020

258133
type: SpeciesReference
stoichiometry: 1.0
species: 400780

409179
type: Reaction
kinetic law: 264205
product: 264193
product: 264181
reactant: 264169
fast: false
reversible: false

264205
type: KineticLaw
local parameters: 207684
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx

207684
type: LocalParameter
units: 257775
value: 3.06E-17

264193
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264181
type: SpeciesReference
stoichiometry: 1.0
species: 404260

264169
type: SpeciesReference
stoichiometry: 1.0
species: 402300

407699
type: Reaction
kinetic law: 260461
product: 260449
reactant: 260437
reactant: 260425
fast: false
reversible: true

260461
type: KineticLaw
local parameters: 207495
local parameters: 207493
notes: k1*CaMKII_slash_CaMKII_minus_CaM*CaMKII_slash_tot_CaM_CaMKII-k2*CaMKII_slash_tot_CaM_CaMKII_slash_CaM_act_286_slash_CaM_act_286_cplx

207495
type: LocalParameter
units: 257775
value: 1.8E-16

207493
type: LocalParameter
units: 257862
value: 1.9805958E-18

260449
type: SpeciesReference
stoichiometry: 1.0
species: 400880

260437
type: SpeciesReference
stoichiometry: 1.0
species: 405980

260425
type: SpeciesReference
stoichiometry: 1.0
species: 400780

413739
type: Reaction
kinetic law: 275362
product: 275350
product: 275338
product: 275326
reactant: 275314
fast: false
reversible: false

275362
type: KineticLaw
local parameters: 208262
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_slash_PKC_minus_phosph_minus_ng_minus_CaM_PSD_cplx

208262
type: LocalParameter
units: 257775
value: 3.15E-17

275350
type: SpeciesReference
stoichiometry: 1.0
species: 405040

275338
type: SpeciesReference
stoichiometry: 1.0
species: 401660

275326
type: SpeciesReference
stoichiometry: 1.0
species: 401600

275314
type: SpeciesReference
stoichiometry: 1.0
species: 405140

413579
type: Reaction
kinetic law: 274954
product: 274942
product: 274929
reactant: 274917
fast: false
reversible: false

274954
type: KineticLaw
local parameters: 208242
notes: k3*PKC_minus_active_slash_PKC_minus_phosph_minus_neurogranin_slash_PKC_minus_phosph_minus_neurogranin_cplx

208242
type: LocalParameter
units: 257775
value: 5.22E-17

274942
type: SpeciesReference
stoichiometry: 1.0
species: 405040

274929
type: SpeciesReference
stoichiometry: 1.0
species: 401560

274917
type: SpeciesReference
stoichiometry: 1.0
species: 405060

409139
type: Reaction
kinetic law: 264109
product: 264097
product: 264085
reactant: 264073
fast: false
reversible: false

264109
type: KineticLaw
local parameters: 207679
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_PSD_slash_dephosph_inhib1_PSD_cplx

207679
type: LocalParameter
units: 257775
value: 3.06E-17

264097
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264085
type: SpeciesReference
stoichiometry: 1.0
species: 404200

264073
type: SpeciesReference
stoichiometry: 1.0
species: 402280

408679
type: Reaction
kinetic law: 262944
product: 262932
product: 262920
reactant: 262908
fast: false
reversible: false

262944
type: KineticLaw
local parameters: 207620
notes: k3*PP1_slash_PP2A_slash_PP2A_minus_dephosph_minus_I1_PSD_slash_PP2A_minus_dephosph_minus_I1_PSD_cplx

207620
type: LocalParameter
units: 257775
value: 1.8E-16

262932
type: SpeciesReference
stoichiometry: 1.0
species: 401880

262920
type: SpeciesReference
stoichiometry: 1.0
species: 404200

262908
type: SpeciesReference
stoichiometry: 1.0
species: 401940

411099
type: Reaction
kinetic law: 268899
product: 268887
reactant: 268875
reactant: 268863
fast: false
reversible: true

268899
type: KineticLaw
local parameters: 207928
local parameters: 207926
notes: k1*AMPAR_slash_A845_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx

207928
type: LocalParameter
units: 257775
value: 2.16E-15

207926
type: LocalParameter
units: 257862
value: 3.5998992E-16

268887
type: SpeciesReference
stoichiometry: 1.0
species: 403500

403500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400680

268875
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268863
type: SpeciesReference
stoichiometry: 1.0
species: 405220

410339
type: Reaction
kinetic law: 267011
product: 266999
product: 266987
reactant: 266975
fast: false
reversible: false

267011
type: KineticLaw
local parameters: 207829
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_12_sbc__slash_PP2B_sbo_12_sbc__cplx

207829
type: LocalParameter
units: 257775
value: 1.8E-16

266999
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266987
type: SpeciesReference
stoichiometry: 1.0
species: 405740

266975
type: SpeciesReference
stoichiometry: 1.0
species: 402900

409059
type: Reaction
kinetic law: 263916
product: 263904
product: 263891
reactant: 263879
fast: false
reversible: false

263916
type: KineticLaw
local parameters: 207669
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_inhib1_slash_dephosph_inhib1_cplx

207669
type: LocalParameter
units: 257775
value: 3.06E-17

263904
type: SpeciesReference
stoichiometry: 1.0
species: 402200

263891
type: SpeciesReference
stoichiometry: 1.0
species: 401800

263879
type: SpeciesReference
stoichiometry: 1.0
species: 402240

409099
type: Reaction
kinetic law: 264013
product: 264001
product: 263989
reactant: 263977
fast: false
reversible: false

264013
type: KineticLaw
local parameters: 207674
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__slash_dephosph_minus_PP1_minus_I_star__cplx

207674
type: LocalParameter
units: 257775
value: 3.06E-17

264001
type: SpeciesReference
stoichiometry: 1.0
species: 402200

263989
type: SpeciesReference
stoichiometry: 1.0
species: 401860

263977
type: SpeciesReference
stoichiometry: 1.0
species: 402260

409479
type: Reaction
kinetic law: 264932
product: 264920
reactant: 264908
reactant: 264896
fast: false
reversible: true

264932
type: KineticLaw
local parameters: 207723
local parameters: 207721
notes: k1*AMPAR_slash_A831_star__B831_star_845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_24_sbc__slash_PP2B_sbo_24_sbc__cplx

207723
type: LocalParameter
units: 257775
value: 7.2E-16

207721
type: LocalParameter
units: 257862
value: 1.8106416E-16

264920
type: SpeciesReference
stoichiometry: 1.0
species: 402460

264908
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264896
type: SpeciesReference
stoichiometry: 1.0
species: 405380

412379
type: Reaction
kinetic law: 272044
product: 272032
product: 272020
reactant: 272008
fast: false
reversible: false

272044
type: KineticLaw
local parameters: 208090
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_3_sbc__slash_PP1_sbo_3_sbc__cplx

208090
type: LocalParameter
units: 257775
value: 1.7E-18

272032
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272020
type: SpeciesReference
stoichiometry: 1.0
species: 405500

272008
type: SpeciesReference
stoichiometry: 1.0
species: 404440

410259
type: Reaction
kinetic law: 266818
product: 266805
product: 266793
reactant: 266781
fast: false
reversible: false

266818
type: KineticLaw
local parameters: 207819
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_10_sbc__slash_PP2B_sbo_10_sbc__cplx

207819
type: LocalParameter
units: 257775
value: 1.8E-16

266805
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266793
type: SpeciesReference
stoichiometry: 1.0
species: 405540

266781
type: SpeciesReference
stoichiometry: 1.0
species: 402860

410059
type: Reaction
kinetic law: 266335
product: 266322
product: 266310
reactant: 266298
fast: false
reversible: false

266335
type: KineticLaw
local parameters: 207794
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_5_sbc__slash_PP2B_sbo_5_sbc__cplx

207794
type: LocalParameter
units: 257775
value: 1.8E-16

266322
type: SpeciesReference
stoichiometry: 1.0
species: 402200

266310
type: SpeciesReference
stoichiometry: 1.0
species: 405600

266298
type: SpeciesReference
stoichiometry: 1.0
species: 402760

411839
type: Reaction
kinetic law: 270740
product: 270728
reactant: 270716
reactant: 270704
fast: false
reversible: true

270740
type: KineticLaw
local parameters: 208023
local parameters: 208021
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_15_sbc__slash_PKA_sbo_15_sbc__cplx

208023
type: LocalParameter
units: 257775
value: 2.16E-15

208021
type: LocalParameter
units: 257862
value: 3.999888E-17

270728
type: SpeciesReference
stoichiometry: 1.0
species: 403880

270716
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270704
type: SpeciesReference
stoichiometry: 1.0
species: 405560

411459
type: Reaction
kinetic law: 269822
product: 269810
product: 269798
reactant: 269786
fast: false
reversible: false

269822
type: KineticLaw
local parameters: 207974
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_5_sbc__slash_PKA_sbo_5_sbc__cplx

207974
type: LocalParameter
units: 257775
value: 5.4E-16

269810
type: SpeciesReference
stoichiometry: 1.0
species: 403180

269798
type: SpeciesReference
stoichiometry: 1.0
species: 405760

269786
type: SpeciesReference
stoichiometry: 1.0
species: 403680

411879
type: Reaction
kinetic law: 270837
modifier: 270825
product: 270812
reactant: 270800
notes: 17 Feb 2005 Halved Vmax as the amount of enzyme has been doubled to get an integer value in the spine. 18 Feb 2005. Updated Km from BRENDA: EC No 4.6.1.1 Rat Km: 0.95 mM Turnover 12/sec. Human Km: 0.3 mM 12 umol/min/mg for mammalia, turnover is 12/sec See PMID 8663304 by Dessauer and Gilman JBC 271 1996 Unfortunately turnover range is from 34 down to 0.1 in different studies, according to BRENDA.
fast: false
reversible: false

270837
type: KineticLaw
local parameters: 208028
local parameters: 208026
notes: kcat*AC_slash_AC1_minus_CaM*AC_slash_ATP/(Km+AC_slash_ATP)

208028
type: LocalParameter
units: 257739
value: 299.9976000192

208026
type: LocalParameter
units: 257775
value: 4.05E-16

270812
type: SpeciesReference
stoichiometry: 1.0
species: 404160

270800
type: SpeciesReference
stoichiometry: 1.0
species: 405900

410699
type: Reaction
kinetic law: 267936
product: 267924
reactant: 267912
reactant: 267900
fast: false
reversible: true

267936
type: KineticLaw
local parameters: 207878
local parameters: 207876
notes: k1*AMPAR_slash_A_B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_18_sbc__slash_PKA_sbo_18_sbc__cplx

207878
type: LocalParameter
units: 257775
value: 2.16E-15

207876
type: LocalParameter
units: 257862
value: 3.5998992E-16

267924
type: SpeciesReference
stoichiometry: 1.0
species: 403300

267912
type: SpeciesReference
stoichiometry: 1.0
species: 403180

267900
type: SpeciesReference
stoichiometry: 1.0
species: 405400

412199
type: Reaction
kinetic law: 271610
product: 271598
reactant: 271586
reactant: 271574
fast: false
reversible: true

271610
type: KineticLaw
local parameters: 208069
local parameters: 208067
notes: k1*CaMKII_slash_CaMKII_star__star__star__minus_PSD*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_Deph_minus_thr286c_slash_Deph_minus_thr286c_cplx

208069
type: LocalParameter
units: 257775
value: 1.0E-16

208067
type: LocalParameter
units: 257862
value: 6.2502E-17

271598
type: SpeciesReference
stoichiometry: 1.0
species: 404360

271586
type: SpeciesReference
stoichiometry: 1.0
species: 404280

271574
type: SpeciesReference
stoichiometry: 1.0
species: 400980

410659
type: Reaction
kinetic law: 267792
product: 267780
product: 267768
reactant: 267756
fast: false
reversible: false

267792
type: KineticLaw
local parameters: 207869
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_17_sbc__slash_PKA_sbo_17_sbc__cplx

207869
type: LocalParameter
units: 257775
value: 5.4E-16

267780
type: SpeciesReference
stoichiometry: 1.0
species: 403180

267768
type: SpeciesReference
stoichiometry: 1.0
species: 405220

267756
type: SpeciesReference
stoichiometry: 1.0
species: 403260

411119
type: Reaction
kinetic law: 268947
product: 268935
product: 268923
reactant: 268911
fast: false
reversible: false

268947
type: KineticLaw
local parameters: 207929
notes: k3*PKA_slash_PKA_minus_active_slash_PKA_sbo_28_sbc__slash_PKA_sbo_28_sbc__cplx

207929
type: LocalParameter
units: 257775
value: 5.4E-16

268935
type: SpeciesReference
stoichiometry: 1.0
species: 403180

268923
type: SpeciesReference
stoichiometry: 1.0
species: 405280

268911
type: SpeciesReference
stoichiometry: 1.0
species: 403500

409839
type: Reaction
kinetic law: 265802
product: 265790
reactant: 265778
reactant: 265766
fast: false
reversible: true

265802
type: KineticLaw
local parameters: 207768
local parameters: 207766
notes: k1*AMPAR_memb_slash_A845_star__B845_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_slash_PP2B_cplx

207768
type: LocalParameter
units: 257775
value: 7.2E-16

207766
type: LocalParameter
units: 257862
value: 2.011824E-17

265790
type: SpeciesReference
stoichiometry: 1.0
species: 402660

265778
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265766
type: SpeciesReference
stoichiometry: 1.0
species: 405680

407380
type: Reaction
kinetic law: 259599
product: 259586
reactant: 259573
notes: The rates for this are poorly constrained. In adipocytes (probably a different PDE) the dephosphorylation is complete within 15 min, but there are no intermediate time points so it could be much faster. Identity of phosphatase etc is still unknown.
fast: false
reversible: true

259599
type: KineticLaw
local parameters: 207439
local parameters: 207437
notes: kf*AC_slash_cAMP_minus_PDE_star_-kb*AC_slash_cAMP_minus_PDE

207439
type: LocalParameter
units: 257775
value: 0.0

207437
type: LocalParameter
units: 257775
value: 9.0E-19

259586
type: SpeciesReference
stoichiometry: 1.0
species: 403980

259573
type: SpeciesReference
stoichiometry: 1.0
species: 404020

407080
type: Reaction
kinetic law: 258495
product: 258483
reactant: 258471
reactant: 258459
notes: K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
fast: false
reversible: true

258495
type: KineticLaw
local parameters: 207367
local parameters: 207365
notes: kf*CaM_slash_CaM_minus_TR2_minus_Ca2*Ca-kb*CaM_slash_CaM_minus_Ca3

207367
type: LocalParameter
units: 257775
value: 9.0E-16

207365
type: LocalParameter
units: 257862
value: 3.2400162E-16

258483
type: SpeciesReference
stoichiometry: 1.0
species: 401700

258471
type: SpeciesReference
stoichiometry: 1.0
species: 400740

258459
type: SpeciesReference
stoichiometry: 1.0
species: 401680

411799
type: Reaction
kinetic law: 270644
product: 270631
reactant: 270619
reactant: 270607
fast: false
reversible: true

270644
type: KineticLaw
local parameters: 208018
local parameters: 208016
notes: k1*AMPAR_memb_slash_A831_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_14_sbc__slash_PKA_sbo_14_sbc__cplx

208018
type: LocalParameter
units: 257775
value: 2.16E-15

208016
type: LocalParameter
units: 257862
value: 3.999888E-17

270631
type: SpeciesReference
stoichiometry: 1.0
species: 403860

270619
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270607
type: SpeciesReference
stoichiometry: 1.0
species: 405560

408079
type: Reaction
kinetic law: 261385
product: 261373
product: 261361
reactant: 261348
fast: false
reversible: false

261385
type: KineticLaw
local parameters: 207540
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_4_sbc__slash_CaMKII_sbo_4_sbc__cplx

207540
type: LocalParameter
units: 257775
value: 5.0E-18

261373
type: SpeciesReference
stoichiometry: 1.0
species: 406100

261361
type: SpeciesReference
stoichiometry: 1.0
species: 405780

261348
type: SpeciesReference
stoichiometry: 1.0
species: 401240

411759
type: Reaction
kinetic law: 270546
product: 270534
reactant: 270522
reactant: 270510
fast: false
reversible: true

270546
type: KineticLaw
local parameters: 208013
local parameters: 208011
notes: k1*AMPAR_memb_slash_A831_star_845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_13_sbc__slash_PKA_sbo_13_sbc__cplx

208013
type: LocalParameter
units: 257775
value: 2.16E-15

208011
type: LocalParameter
units: 257862
value: 3.999888E-17

270534
type: SpeciesReference
stoichiometry: 1.0
species: 403840

270522
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270510
type: SpeciesReference
stoichiometry: 1.0
species: 405620

411599
type: Reaction
kinetic law: 270160
product: 270148
reactant: 270136
reactant: 270123
fast: false
reversible: true

270160
type: KineticLaw
local parameters: 207993
local parameters: 207991
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_9_sbc__slash_PKA_sbo_9_sbc__cplx

207993
type: LocalParameter
units: 257775
value: 2.16E-15

207991
type: LocalParameter
units: 257862
value: 3.999888E-17

270148
type: SpeciesReference
stoichiometry: 1.0
species: 403760

270136
type: SpeciesReference
stoichiometry: 1.0
species: 403180

270123
type: SpeciesReference
stoichiometry: 1.0
species: 405660

412779
type: Reaction
kinetic law: 273022
product: 273010
product: 272998
reactant: 272986
fast: false
reversible: false

273022
type: KineticLaw
local parameters: 208141
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_13_sbc__slash_PP1_sbo_13_sbc__cplx

208141
type: LocalParameter
units: 257775
value: 1.7E-18

273010
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272998
type: SpeciesReference
stoichiometry: 1.0
species: 405660

272986
type: SpeciesReference
stoichiometry: 1.0
species: 404640

412739
type: Reaction
kinetic law: 272926
product: 272914
product: 272902
reactant: 272890
fast: false
reversible: false

272926
type: KineticLaw
local parameters: 208136
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_12_sbc__slash_PP1_sbo_12_sbc__cplx

208136
type: LocalParameter
units: 257775
value: 1.7E-18

272914
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272902
type: SpeciesReference
stoichiometry: 1.0
species: 405720

272890
type: SpeciesReference
stoichiometry: 1.0
species: 404620

412579
type: Reaction
kinetic law: 272540
product: 272528
product: 272515
reactant: 272502
fast: false
reversible: false

272540
type: KineticLaw
local parameters: 208115
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_8_sbc__slash_PP1_sbo_8_sbc__cplx

208115
type: LocalParameter
units: 257775
value: 3.5E-18

272528
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272515
type: SpeciesReference
stoichiometry: 1.0
species: 405680

272502
type: SpeciesReference
stoichiometry: 1.0
species: 404540

407020
type: Reaction
kinetic law: 258350
product: 258338
reactant: 258326
reactant: 258314
fast: false
reversible: true

258350
type: KineticLaw
local parameters: 207358
local parameters: 207356
notes: kf*CaMKII_slash_CaMKII_minus_PSD*CaM_slash_CaM_minus_Ca4_minus_PSD-kb*CaMKII_slash_CaMKII_minus_CaM_minus_PSD

207358
type: LocalParameter
units: 257775
value: 0.0

207356
type: LocalParameter
units: 257862
value: 4.99998E-16

258338
type: SpeciesReference
stoichiometry: 1.0
species: 401060

258326
type: SpeciesReference
stoichiometry: 1.0
species: 401720

258314
type: SpeciesReference
stoichiometry: 1.0
species: 401000

409659
type: Reaction
kinetic law: 265366
product: 265353
product: 265341
reactant: 265329
fast: false
reversible: false

265366
type: KineticLaw
local parameters: 207744
notes: k3*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_PP2B_sbo_28_sbc__slash_PP2B_sbo_28_sbc__cplx

207744
type: LocalParameter
units: 257775
value: 1.8E-16

265353
type: SpeciesReference
stoichiometry: 1.0
species: 402200

265341
type: SpeciesReference
stoichiometry: 1.0
species: 405380

265329
type: SpeciesReference
stoichiometry: 1.0
species: 402540

408379
type: Reaction
kinetic law: 262163
product: 262151
product: 262138
reactant: 262126
fast: false
reversible: false

262163
type: KineticLaw
local parameters: 207580
notes: k3*CaMKII_slash_actCaMKII_minus_PSD_slash_CaMKII_sbo_12_sbc__slash_CaMKII_sbo_12_sbc__cplx

207580
type: LocalParameter
units: 257775
value: 5.0E-18

262151
type: SpeciesReference
stoichiometry: 1.0
species: 406100

262138
type: SpeciesReference
stoichiometry: 1.0
species: 405800

262126
type: SpeciesReference
stoichiometry: 1.0
species: 401400

412499
type: Reaction
kinetic law: 272334
product: 272322
product: 272310
reactant: 272298
fast: false
reversible: false

272334
type: KineticLaw
local parameters: 208105
notes: k3*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_6_sbc__slash_PP1_sbo_6_sbc__cplx

208105
type: LocalParameter
units: 257775
value: 1.7E-18

272322
type: SpeciesReference
stoichiometry: 1.0
species: 404280

272310
type: SpeciesReference
stoichiometry: 1.0
species: 405520

272298
type: SpeciesReference
stoichiometry: 1.0
species: 404500

413119
type: Reaction
kinetic law: 273842
product: 273830
reactant: 273818
reactant: 273806
fast: false
reversible: true

273842
type: KineticLaw
local parameters: 208186
local parameters: 208184
notes: k1*AMPAR_memb_slash_A845_star__B831_star_*PP1_PSD_slash_PP1_minus_active_PSD-k2*PP1_PSD_slash_PP1_minus_active_PSD_slash_PP1_sbo_22_sbc__slash_PP1_sbo_22_sbc__cplx

208186
type: LocalParameter
units: 257775
value: 1.4E-17

208184
type: LocalParameter
units: 257862
value: 8.7498E-18

273830
type: SpeciesReference
stoichiometry: 1.0
species: 404820

273818
type: SpeciesReference
stoichiometry: 1.0
species: 404280

273806
type: SpeciesReference
stoichiometry: 1.0
species: 405660

410660
type: Reaction
kinetic law: 267840
product: 267828
reactant: 267816
reactant: 267804
fast: false
reversible: true

267840
type: KineticLaw
local parameters: 207873
local parameters: 207871
notes: k1*AMPAR_slash_A831_star__B*PKA_slash_PKA_minus_active-k2*PKA_slash_PKA_minus_active_slash_PKA_sbo_16_sbc__slash_PKA_sbo_16_sbc__cplx

207873
type: LocalParameter
units: 257775
value: 2.16E-15

207871
type: LocalParameter
units: 257862
value: 3.5998992E-16

267828
type: SpeciesReference
stoichiometry: 1.0
species: 403280

267816
type: SpeciesReference
stoichiometry: 1.0
species: 403180

267804
type: SpeciesReference
stoichiometry: 1.0
species: 405200

406320
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 400700

413599
type: Reaction
kinetic law: 275002
product: 274990
reactant: 274978
reactant: 274966
notes: Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
fast: false
reversible: true

275002
type: KineticLaw
local parameters: 208246
local parameters: 208244
notes: k1*CaM_slash_neurogranin_minus_CaM*PKC_minus_active-k2*PKC_minus_active_slash_PKC_minus_phosph_minus_ng_minus_CaM_slash_PKC_minus_phosph_minus_ng_minus_CaM_cplx

208246
type: LocalParameter
units: 257775
value: 1.26E-16

208244
type: LocalParameter
units: 257862
value: 5.507838E-18

274990
type: SpeciesReference
stoichiometry: 1.0
species: 405080

274978
type: SpeciesReference
stoichiometry: 1.0
species: 405040

274966
type: SpeciesReference
stoichiometry: 1.0
species: 401540

409159
type: Reaction
kinetic law: 264157
product: 264145
reactant: 264133
reactant: 264121
fast: false
reversible: true

264157
type: KineticLaw
local parameters: 207683
local parameters: 207681
notes: k1*PP1_PSD_slash_PP1_minus_I1_star_*PP2B_slash_CaM_Ca_n_minus_CaNAB-k2*PP2B_slash_CaM_Ca_n_minus_CaNAB_slash_dephosph_minus_PP1_minus_I_star__PSD_slash_dephosph_minus_PP1_minus_I_star__PSD_cplx

207683
type: LocalParameter
units: 257775
value: 1.224E-16

207681
type: LocalParameter
units: 257862
value: 3.420036E-18

264145
type: SpeciesReference
stoichiometry: 1.0
species: 402300

264133
type: SpeciesReference
stoichiometry: 1.0
species: 402200

264121
type: SpeciesReference
stoichiometry: 1.0
species: 404240