MODEL8938094216
type: SBMLModel
species: metaid_0000006
species: metaid_0000015
length unit: length
parameter: metaid_0000042
parameter: metaid_0000041
parameter: metaid_0000039
species: metaid_0000013
parameter: metaid_0000044
reaction: metaid_0000071
parameter: metaid_0000036
reaction: metaid_0000083
reaction: metaid_0000065
species: metaid_0000017
parameter: metaid_0000030
species: metaid_0000009
time units: 131570
reaction: metaid_0000088
reaction: metaid_0000068
reaction: metaid_0000067
species: metaid_0000007
curated: false
species: metaid_0000012
rule: metaid_0000060
parameter: metaid_0000046
parameter: metaid_0000045
reaction: metaid_0000072
substance units: metaid_0000048
parameter: metaid_0000031
species: metaid_0000010
species: metaid_0000091
parameter: metaid_0000043
units def: metaid_0000048
parameter: metaid_0000037
reaction: metaid_0000084
species: metaid_0000016
rule: metaid_0000056
species: metaid_0000008
reaction: metaid_0000089
reaction: metaid_0000069
notes: This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
parameter: metaid_0000034
reaction: metaid_0000082
name: dAlcantara2003_SynapticPlasticity
compartment: metaid_0000003
reaction: metaid_0000090
parameter: metaid_0000040
reaction: metaid_0000087
species: metaid_0000011
parameter: metaid_0000032
volume units: 679943
area units: area
species: metaid_0000019
parameter: metaid_0000038
reaction: metaid_0000086
reaction: metaid_0000085
parameter: metaid_0000035
is described by: http://identifiers.org/pubmed/12823459
species: metaid_0000018
species: metaid_0000059
reaction: metaid_0000070

metaid_0000006
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: S*

metaid_0000003
type: Compartment
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units: 679943
size: 1.0
spatial dimensions: 3.0
name: spine

metaid_0000015
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: metaid_0000003
name: R

metaid_0000042
type: Parameter
constant: true
value: 1.0
name: r2

metaid_0000041
type: Parameter
constant: true
value: 0.1
name: r1 times PKA*

metaid_0000039
type: Parameter
constant: true
value: 2000.0
name: d1

metaid_0000013
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: D*

metaid_0000044
type: Parameter
constant: true
value: 0.1
name: r4

metaid_0000071
type: Reaction
kinetic law: 138773
modifier: 138761
product: 138749
reactant: 138737
fast: false
reversible: false
name: full AMPAR activation by active CaMKII

metaid_0000008
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: K'

138749
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

metaid_0000017
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: R*

138737
type: SpeciesReference
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species: metaid_0000016

metaid_0000016
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: R'

metaid_0000036
type: Parameter
constant: true
value: 0.03
name: k4

metaid_0000083
type: Reaction
kinetic law: 138917
modifier: 138905
product: 138893
reactant: 138881
fast: false
reversible: false
name: CaMKII dephosphorylation

metaid_0000018
type: Species
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boundary condition: false
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initial concentration: 2.0
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138893
type: SpeciesReference
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species: metaid_0000008

138881
type: SpeciesReference
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species: metaid_0000009

metaid_0000009
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
name: K*

metaid_0000065
type: Reaction
kinetic law: 138567
product: 138554
reactant: 138542
reactant: 138530
fast: false
reversible: false
name: CaMKII binding to CaM

138554
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

138542
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

138530
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000007

metaid_0000007
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.5
initial amount: NaN
in compartment: metaid_0000003
name: K

metaid_0000030
type: Parameter
constant: true
value: 7.0
name: Kd

metaid_0000088
type: Reaction
kinetic law: 139163
modifier: 139151
product: 139138
reactant: 139126
fast: false
reversible: false
name: full AMPAR activation by autophosphorylated CaMKII

139138
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

139126
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

metaid_0000068
type: Reaction
kinetic law: 138652
product: 138640
reactant: 138628
reactant: 138616
fast: false
reversible: false
name: Calcineurin or PP2B activation

138640
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000011
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000003
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138628
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

138616
type: SpeciesReference
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species: metaid_0000010

metaid_0000010
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: metaid_0000003
name: N

metaid_0000067
type: Reaction
kinetic law: 138603
product: 138591
reactant: 138579
fast: false
reversible: false
name: CaMKII autophosphorylation

138591
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

138579
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000012
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.0
initial amount: NaN
in compartment: metaid_0000003
name: D

metaid_0000046
type: Parameter
constant: true
value: 3.0E-5
name: p2

metaid_0000045
type: Parameter
constant: true
value: 0.03
name: p1

metaid_0000072
type: Reaction
kinetic law: 138821
product: 138809
reactant: 138797
reactant: 138785
fast: false
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name: PP1 inactivation

138809
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species: metaid_0000019

metaid_0000019
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138797
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138785
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species: metaid_0000013

metaid_0000048
type: SBMLUnitsDef
unit: 138518
name: substance

138518
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

metaid_0000031
type: Parameter
constant: true
value: 4.0
name: Hill coefficient

metaid_0000091
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.001
initial amount: NaN
in compartment: metaid_0000003
name: Ca2plus

metaid_0000043
type: Parameter
constant: true
value: 10.0
name: r3

metaid_0000037
type: Parameter
constant: true
value: 1666.0
name: n1

metaid_0000084
type: Reaction
kinetic law: 138966
product: 138954
product: 138942
reactant: 138930
fast: false
reversible: false
name: Calcineurin or PP2B inactivation

138954
type: SpeciesReference
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species: metaid_0000010

138942
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species: metaid_0000006

138930
type: SpeciesReference
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species: metaid_0000011

metaid_0000089
type: Reaction
kinetic law: 139211
modifier: 139199
product: 139187
reactant: 139175
fast: false
reversible: false
name: intermediate AMPAR deactivation

139187
type: SpeciesReference
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species: metaid_0000016

139175
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

metaid_0000069
type: Reaction
kinetic law: 138688
product: 138676
reactant: 138664
fast: false
reversible: false
name: DARPP-32 activation

138676
type: SpeciesReference
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species: metaid_0000013

138664
type: SpeciesReference
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species: metaid_0000012

metaid_0000034
type: Parameter
constant: true
value: 2.17
name: k2

metaid_0000082
type: Reaction
kinetic law: 138869
product: 138857
product: 138845
reactant: 138833
fast: false
reversible: false
name: CaM unbinding from CaMKII

138857
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000006

138845
type: SpeciesReference
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species: metaid_0000007

138833
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000090
type: Reaction
kinetic law: 139259
product: 139247
product: 139235
reactant: 139223
fast: false
reversible: false
name: PP1 activation

139247
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

139235
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

139223
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

metaid_0000040
type: Parameter
constant: true
value: 0.002
name: d2 times PKA*

metaid_0000087
type: Reaction
kinetic law: 139114
modifier: 139102
product: 139090
reactant: 139078
fast: false
reversible: false
name: AMPAR complete deactivation by PP1

139090
type: SpeciesReference
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species: metaid_0000015

139078
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

metaid_0000032
type: Parameter
constant: true
value: 150.0
name: k1

metaid_0000038
type: Parameter
constant: true
value: 10.0
name: n2

metaid_0000086
type: Reaction
kinetic law: 139066
modifier: 139054
product: 139041
reactant: 139029
fast: false
reversible: false
name: AMPAR complete deactivation by calcineurin

139041
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015

139029
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

metaid_0000085
type: Reaction
kinetic law: 139016
modifier: 139003
product: 138990
reactant: 138978
fast: false
reversible: false
name: DARPP-32 deactivation

138990
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

138978
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

metaid_0000035
type: Parameter
constant: true
value: 0.5
name: k3

metaid_0000059
type: Species
constant: true
boundary condition: false
has only substance units: false
initial concentration: 30.0
initial amount: NaN
in compartment: metaid_0000003
name: S total

metaid_0000070
type: Reaction
kinetic law: 138725
product: 138713
reactant: 138701
fast: false
reversible: false
name: AMPAR intermediate activation

138713
type: SpeciesReference
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species: metaid_0000016

138701
type: SpeciesReference
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species: metaid_0000015