MODEL8687196544
type: SBMLModel
compartment: 631734
units def: 124186
parameter: 631810
parameter: 631782
parameter: 631851
rule: 631772
rule: 631762
parameter: 631842
parameter: 631832
parameter: 631824
parameter: 631819
rule: 631745
parameter: 631813
parameter: 631785
parameter: 631788
parameter: 631844
parameter: 631847
parameter: 631826
rule: 631738
rule: 631754
rule: 631744
rule: 631736
rule: 631769
is described by: http://identifiers.org/pubmed/16339881
parameter: 631815
parameter: 631799
parameter: 631849
rule: 631741
units def: 124088
parameter: 631779
rule: 631759
units def: 124113
parameter: 631781
rule: 631765
parameter: 631840
parameter: 631830
parameter: 631822
parameter: 631808
rule: 631756
volume units: 679943
substance units: metaid_0000106
parameter: 631820
parameter: 631811
parameter: 631801
parameter: 631802
parameter: 631795
rule: 631760
rule: 631739
parameter: 631846
parameter: 631836
name: Niederer2006_CardiacMyocyteRelaxation
parameter: 631776
units def: 124150
parameter: 631804
parameter: 631817
parameter: 631807
parameter: 631798
parameter: 631838
rule: 631742
parameter: 631791
rule: 631750
parameter: 631778
curated: false
rule: 631766
area units: area
rule: 631757
rule: 631747
units def: 124283
notes: This a model from the article: A quantitative analysis of cardiac myocyte relaxation: a simulation study. Niederer SA, Hunter PJ, Smith NP. Biophys J. 2006:90(5):1697-722. 16339881 , Abstract: The determinants of relaxation in cardiac muscle are poorly understood, yet compromised relaxation accompanies various pathologies and impaired pump function. In this study, we develop a model of active contraction to elucidate the relative importance of the [Ca2+]i transient magnitude, the unbinding of Ca2+ from troponin C (TnC), and the length-dependence of tension and Ca2+ sensitivity on relaxation. Using the framework proposed by one of our researchers, we extensively reviewed experimental literature, to quantitatively characterize the binding of Ca2+ to TnC, the kinetics of tropomyosin, the availability of binding sites, and the kinetics of crossbridge binding after perturbations in sarcomere length. Model parameters were determined from multiple experimental results and modalities (skinned and intact preparations) and model results were validated against data from length step, caged Ca2+, isometric twitches, and the half-time to relaxation with increasing sarcomere length experiments. A factorial analysis found that the [Ca2+]i transient and the unbinding of Ca2+ from TnC were the primary determinants of relaxation, with a fivefold greater effect than that of length-dependent maximum tension and twice the effect of tension-dependent binding of Ca2+ to TnC and length-dependent Ca2+ sensitivity. The affects of the [Ca2+]i transient and the unbinding rate of Ca2+ from TnC were tightly coupled with the effect of increasing either factor, depending on the reference [Ca2+]i transient and unbinding rate. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Niederer, Hunter, Smith. (2006) - version02 The original CellML model was created by: Terkildsen, Jonna, j.terkildsen@auckland.ac.nz The University of Auckland Auckland …
length unit: length
parameter: 631793
parameter: 631784
units def: 124064
rule: 631763
parameter: 631834
rule: 631771
rule: 631748
parameter: 631773
parameter: 631805

631734
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

124186
type: SBMLUnitsDef
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unit: 124210
unit: 124198
name: per_mM_per_ms

124222
type: SBMLUnit
exponent: -1.0
scale: -3
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kind: SECOND

124210
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scale: 0
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kind: LITRE

124198
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE

631810
type: Parameter
constant: true
units: 124064
value: 0.2
name: k_Ref_off

124064
type: SBMLUnitsDef
unit: 124076
name: per_ms

124076
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND

631782
type: Parameter
constant: true
units: 124064
value: 0.002
name: alpha_r1

631851
type: Parameter
constant: false
units: 124150
value: NaN
name: Tension

124150
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unit: 124162
name: N_per_mm2

124174
type: SBMLUnit
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scale: -3
multipler: 1.0
kind: METRE

124162
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kind: NEWTON

631842
type: Parameter
constant: true
units: dimensionless
value: 138.0
name: A_2

631832
type: Parameter
constant: true
units: dimensionless
value: 0.35
name: a

631824
type: Parameter
constant: true
units: 124150
value: 56.2
name: T_ref

631819
type: Parameter
constant: false
units: dimensionless
value: NaN
name: lambda_prev

631813
type: Parameter
constant: false
units: dimensionless
value: NaN
name: lambda

631785
type: Parameter
constant: true
units: dimensionless
value: 3.0
name: n_Rel

631788
type: Parameter
constant: true
units: dimensionless
value: 3.0
name: n_Hill

631844
type: Parameter
constant: true
units: dimensionless
value: 129.0
name: A_3

631847
type: Parameter
constant: true
units: 124064
value: 0.13
name: alpha_2

631826
type: Parameter
constant: false
units: 124150
value: NaN
name: T_Base

631815
type: Parameter
constant: false
units: dimensionless
value: NaN
name: ExtensionRatio

631799
type: Parameter
constant: false
units: 124064
value: NaN
name: K_1

631849
type: Parameter
constant: true
units: 124064
value: 0.625
name: alpha_3

124088
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name: ms

124101
type: SBMLUnit
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631779
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units: dimensionless
value: NaN
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unit: 124126
name: mM

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631781
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units: 124064
value: 0.008
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631840
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constant: true
units: dimensionless
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name: A_1

631830
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units: dimensionless
value: NaN
name: Q

631822
type: Parameter
constant: true
units: dimensionless
value: 4.9
name: beta_0

631808
type: Parameter
constant: true
units: 124186
value: 100.0
name: k_on

631820
type: Parameter
constant: false
units: dimensionless
value: NaN
name: overlap

631811
type: Parameter
constant: true
units: dimensionless
value: 2.0
name: gamma_trpn

631801
type: Parameter
constant: false
units: 124064
value: NaN
name: alpha_Tm

631802
type: Parameter
constant: false
units: 124064
value: NaN
name: beta_Tm

631795
type: Parameter
constant: false
units: 124113
value: NaN
name: Ca_50

631846
type: Parameter
constant: true
units: 124064
value: 0.03
name: alpha_1

631836
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: Q_2

631776
type: Parameter
constant: false
units: 124113
value: 0.067593139865
name: TRPN

631804
type: Parameter
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units: 124235
value: NaN
name: J_TRPN

124235
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unit: 124259
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name: mM_per_ms

124271
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124259
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124247
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631817
type: Parameter
constant: false
units: 124064
value: NaN
name: dExtensionRatiodt

631807
type: Parameter
constant: false
units: 124064
value: NaN
name: k_off

631798
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units: 124064
value: NaN
name: K_2

631838
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constant: false
units: dimensionless
value: 0.0
name: Q_3

631791
type: Parameter
constant: true
units: dimensionless
value: 0.85
name: z_p

631778
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constant: false
units: dimensionless
value: 0.014417937837
name: z

124283
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124295
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631793
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units: dimensionless
value: -4.0
name: beta_1

631784
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631834
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name: Q_1

631773
type: Parameter
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units: 124113
value: NaN
name: Ca_i

631805
type: Parameter
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units: 124113
value: 0.07
name: Ca_TRPN_Max

631796
type: Parameter
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units: 124113
value: NaN
name: Ca_TRPN_50

631787
type: Parameter
constant: true
units: dimensionless
value: 0.15
name: K_z

631828
type: Parameter
constant: false
units: 124150
value: NaN
name: T_0

631790
type: Parameter
constant: true
units: 124113
value: 0.00105
name: Ca_50ref

631775
type: Parameter
constant: false
units: 124113
value: NaN
name: Ca_b