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name: Yang2008_AAnetwork_PLT
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created:
  W3 CDTF: Thu Apr 22 02:06:26 BST 2010
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modified:
  W3 CDTF: Thu Mar 03 23:47:36 GMT 2011
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is described by: http://identifiers.org/pubmed/18985027
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creator:
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    orgname: EMBL-EBI
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modified:
  W3 CDTF: Thu Mar 03 23:47:36 GMT 2011
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notes: This is the arachidonic acid metabolic network model for human platelet cells (PLT) described in the article: Finding multiple target optimal intervention in disease-related molecular network. Yang K, Bai H, Ouyang Q, Lai L, Tang C. Mol Syst Biol. 2008;4:228. Epub 2008 Nov 4.; PMID: 18985027 ,doi: 10.1038/msb.2008.60 Abstract: Drugs against multiple targets may overcome the many limitations of single targets and achieve a more effective and safer control of the disease. Numerous high-throughput experiments have been performed in this emerging field. However, systematic identification of multiple drug targets and their best intervention requires knowledge of the underlying disease network and calls for innovative computational methods that exploit the network structure and dynamics. Here, we develop a robust computational algorithm for finding multiple target optimal intervention (MTOI) solutions in a disease network. MTOI identifies potential drug targets and suggests optimal combinations of the target intervention that best restore the network to a normal state, which can be customer designed. We applied MTOI to an inflammation-related network. The well-known side effects of the traditional non-steriodal anti-inflammatory drugs and the recently recalled Vioxx were correctly accounted for in our network model. A number of promising MTOI solutions were found to be both effective and safer. The model is an updated version of the supplementary material of the article ( Supplementary Information 3 ). The only difference are the parameter names. Originally created by libAntimony v1.3 (using libSBML 4.1.0-b1) This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In…
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