MODEL7980735163
type: SBMLModel
parameter: 467877
parameter: 467710
parameter: 467843
parameter: 467922
rule: 467691
rule: 467649
parameter: 467825
parameter: 467870
parameter: 467756
parameter: 467889
parameter: 467738
parameter: 467722
parameter: 467801
parameter: 467789
parameter: 467855
parameter: 467704
rule: 467637
parameter: 467890
parameter: 467837
parameter: 467776
units def: 993809
parameter: 467768
parameter: 467782
parameter: 467734
curated: false
parameter: 467867
parameter: 467830
parameter: 467857
parameter: 467716
parameter: 467849
rule: 467683
parameter: 467902
units def: 993833
parameter: 467884
rule: 467668
is described by: http://identifiers.org/pubmed/15653786
parameter: 467750
parameter: 467917
parameter: 467901
parameter: 467883
parameter: 467728
parameter: 467783
rule: 467650
rule: 467671
parameter: 467896
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parameter: 467762
parameter: 467895
parameter: 467795
units def: 994016
parameter: 467729
parameter: 467774
parameter: 467907
parameter: 467743
rule: 467685
parameter: 467702
parameter: 467842
rule: 467692
parameter: 467824
rule: 467652
parameter: 467755
rule: 467673
parameter: 467737
notes: This a model from the article: Ionic current model of a hypoglossal motoneuron. Purvis LK, Butera RJ. J Neurophysiol. 2005:93(2):723-33. 18068197 , Abstract: We have developed a single-compartment, electrophysiological, hypoglossal motoneuron (HM) model based primarily on experimental data from neonatal rat HMs. The model is able to reproduce the fine features of the HM action potential: the fast afterhyperpolarization, the afterdepolarization, and the medium-duration afterhyperpolarization (mAHP). The model also reproduces the repetitive firing properties seen in neonatal HMs and replicates the neuron's response to pharmacological experiments. The model was used to study the role of specific ionic currents in HM firing and how variations in the densities of these currents may account for age-dependent changes in excitability seen in HMs. By varying the density of a fast inactivating calcium current, the model alternates between accelerating and adapting firing patterns. Modeling the age-dependent increase in H current density accounts for the decrease in mAHP duration observed experimentally, but does not fully account for the decrease in input resistance. An increase in the density of the voltage-dependent potassium currents and the H current is required to account for the decrease in input resistance. These changes also account for the age-dependent decrease in action potential duration. This model was taken from the CellML repository and automatically converted to SBML. The original model was: purvis, butera, (2005) - version03 The original CellML model was created by: Nunns, Geoffrey, Rogan gnunns1@jhem.jhu.edu The University of Auckland Auckland Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been ded…
parameter: 467800
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parameter: 467749
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467728
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993894
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467701
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467920
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993906
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