MODEL7909395757
type: SBMLModel
parameter: 623101
rule: 623056
parameter: 623074
parameter: 623094
parameter: 623095
rule: 623038
parameter: 623082
substance units: 106194
parameter: 623089
parameter: 623119
rule: 623047
rule: 623061
parameter: 623076
rule: 623067
parameter: 623077
parameter: 623106
parameter: 623107
rule: 623059
parameter: 623104
parameter: 623113
rule: 623064
parameter: 623098
parameter: 623085
parameter: 623086
units def: 960682
parameter: 623092
name: Razumova2000_MyofilamentContractileBehaviour
parameter: 623079
parameter: 623073
parameter: 623110
rule: 623039
parameter: 623080
parameter: 623088
compartment: 623036
parameter: 623118
rule: 623062
parameter: 623091
rule: 623043
rule: 623055
parameter: 623103
parameter: 623100
area units: area
rule: 623040
parameter: 623112
rule: 623065
parameter: 623097
length unit: length
rule: 623052
parameter: 623069
volume units: metaid_0000217
curated: false
is described by: http://identifiers.org/pubmed/10827989
parameter: 623115
parameter: 623116
rule: 623050
parameter: 623083
parameter: 623070
time units: 945099
parameter: 623071
rule: 623046
rule: 623041
rule: 623058
parameter: 623109
rule: 623053
notes: This a model from the article: Different myofilament nearest-neighbor interactions have distinctive effects on contractile behavior. Razumova MV, Bukatina AE, Campbell KB. Biophys J. 2000;78(6):3120-37 10827989 , Abstract: Cooperativity in contractile behavior of myofilament systems almost assuredly arises because of interactions between neighboring sites. These interactions may be of different kinds. Tropomyosin thin-filament regulatory units may have neighbors in steric blocking positions (off) or steric permissive positions (on). The position of these neighbors influence the tendency for the regulatory unit to assume the on or off state. Likewise, the tendency of a myosin cross-bridge to achieve a force-bearing state may be influenced by whether neighboring cross-bridges are in force-bearing states. Also, a cross-bridge in the force-bearing state may influence the tendency of a regulatory unit to enter the on state. We used a mathematical model to examine the influence of each of these three kinds of neighbor interactions on the steady-state force-pCa relation and on the dynamic force redevelopment process. Each neighbor interaction was unique in its effects on maximal Ca(2+)-activated force, position, and symmetry of the force-pCa curve and on the Hill coefficient. Also, each neighbor interaction had a distinctive effect on the time course of force development as assessed by its rate coefficient, k(dev). These diverse effects suggest that variations in all three kinds of nearest-neighbor interactions may be responsible for a wide variety of currently unexplained observations of myofilament contractile behavior. This model was taken from the CellML repository and automatically converted to SBML. The original model was: razumova, bukatina, campbell. (2000) - version03 The original CellML model was created by: Nunns, Geoffrey, Rogan gnunns1@jhem.jhu.edu The University of Auckland Auckland Bioengineering Institute This model originates from BioModels Database: A Dat…
rule: 623049
rule: 623044

623101
type: Parameter
constant: true
units: 960682
value: 4.0
name: g

960682
type: SBMLUnitsDef
unit: 960694
name: per_second

960694
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

623074
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: A_1

623094
type: Parameter
constant: true
units: 960682
value: 50.0
name: k_Ca_off

623095
type: Parameter
constant: true
units: 960682
value: 50.0
name: f_0

623082
type: Parameter
constant: false
units: dimensionless
value: NaN
name: lambda_A_1

623089
type: Parameter
constant: true
units: 960682
value: 0.0
name: k_0_on

623119
type: Parameter
constant: false
units: 960682
value: NaN
name: k_off

623076
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: A_2

623077
type: Parameter
constant: false
units: dimensionless
value: NaN
name: lambda_off

623106
type: Parameter
constant: true
units: dimensionless
value: 1.0
name: w

623107
type: Parameter
constant: true
units: dimensionless
value: 1.0
name: v

623104
type: Parameter
constant: true
units: dimensionless
value: 1.0
name: u

623113
type: Parameter
constant: false
units: 960682
value: NaN
name: k_w_off

623098
type: Parameter
constant: true
units: 960682
value: 8.0
name: h

623085
type: Parameter
constant: false
units: dimensionless
value: NaN
name: lambda_A2_cyc

623086
type: Parameter
constant: false
units: dimensionless
value: NaN
name: Ca

623092
type: Parameter
constant: true
units: 960682
value: 120.0
name: k_Ca_on

623079
type: Parameter
constant: false
units: dimensionless
value: NaN
name: lambda_on

623073
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: D

623110
type: Parameter
constant: false
units: 960682
value: NaN
name: k_u_off

623080
type: Parameter
constant: false
units: dimensionless
value: NaN
name: lambda_D

623088
type: Parameter
constant: false
units: dimensionless
value: NaN
name: Ca_50

623036
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

623118
type: Parameter
constant: false
units: 960682
value: NaN
name: k_on

623091
type: Parameter
constant: true
units: 960682
value: 100.0
name: k_0_off

623103
type: Parameter
constant: true
units: dimensionless
value: 1.0
name: n_H

623100
type: Parameter
constant: true
units: 960682
value: 6.0
name: h_prime

623112
type: Parameter
constant: false
units: 960682
value: NaN
name: k_w_on

623097
type: Parameter
constant: true
units: 960682
value: 400.0
name: f_prime_0

623069
type: Parameter
constant: false
units: dimensionless
value: NaN
name: F

623115
type: Parameter
constant: false
units: 960682
value: NaN
name: f

623116
type: Parameter
constant: false
units: 960682
value: NaN
name: f_prime

623083
type: Parameter
constant: false
units: dimensionless
value: NaN
name: lambda_A_2

623070
type: Parameter
constant: true
units: dimensionless
value: 1.0
name: R_T

623071
type: Parameter
constant: false
units: dimensionless
value: NaN
name: R_off

623109
type: Parameter
constant: false
units: 960682
value: NaN
name: k_u_on