MODEL7891585309
type: SBMLModel
parameter: 685968
parameter: 685978
parameter: 686021
parameter: 686012
parameter: 685996
parameter: 686003
parameter: 685972
parameter: 686041
compartment: 685933
parameter: 686017
curated: false
parameter: 685986
rule: 685964
volume units: metaid_0000217
parameter: 686000
area units: area
parameter: 686032
parameter: 686037
parameter: 686014
units def: 914103
rule: 685954
rule: 685944
parameter: 686052
parameter: 686035
parameter: 686045
length unit: length
parameter: 686028
parameter: 685982
parameter: 686043
parameter: 686019
rule: 685936
time units: 914178
parameter: 685988
parameter: 685998
name: Butera1999_Bursting_Pacemaker_Neuron_Model_1
parameter: 685980
parameter: 685990
rule: 685950
rule: 685940
parameter: 686039
parameter: 686049
rule: 685946
is described by: http://identifiers.org/pubmed/10400966
units def: 914055
parameter: 685974
parameter: 686033
rule: 685960
substance units: 106194
parameter: 686051
parameter: 685967
rule: 685966
parameter: 686056
parameter: 686010
parameter: 686015
parameter: 686025
parameter: 686054
parameter: 686047
units def: 914079
parameter: 685984
parameter: 685994
parameter: 686001
rule: 685942
parameter: 686030
rule: 685956
parameter: 686023
rule: 685938
parameter: 686006
units def: 914128
parameter: 685970
units def: 914154
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notes: This is the model without the slow potassium current, model 1, described in the article: Models of respiratory rhythm generation in the pre-Bötzinger complex. I. Bursting pacemaker neurons. Butera RJ Jr, Rinzel J, Smith JC. J Neurophysiol. 1999 Jul;82(1):382-97. Pubmed ID: 10400966 , full text at the Journal of Neurophysiology . Abstract: A network of oscillatory bursting neurons with excitatory coupling is hypothesized to define the primary kernel for respiratory rhythm generation in the pre-Bötzinger complex (pre-BötC) in mammals. Two minimal models of these neurons are proposed. In model 1, bursting arises via fast activation and slow inactivation of a persistent Na+ current INaP-h. In model 2, bursting arises via a fast-activating persistent Na+ current INaP and slow activation of a K+ current IKS. In both models, action potentials are generated via fast Na+ and K+ currents. The two models have few differences in parameters to facilitate a rigorous comparison of the two different burst-generating mechanisms. Both models are consistent with many of the dynamic features of electrophysiological recordings from pre-BötC oscillatory bursting neurons in vitro, including voltage-dependent activity modes (silence, bursting, and beating), a voltage-dependent burst frequency that can vary from 0.05 to > 1 Hz, and a decaying spike frequency during bursting. These results are robust and persist across a wide range of parameter values for both models. However, the dynamics of model 1 are more consistent with experimental data in that the burst duration decreases as the baseline membrane potential is depolarized and the model has a relatively flat membrane potential trajectory during the interburst interval. We propose several experimental tests to demonstrate the validity of either model and to differentiate between the two mechanisms. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Butera, Rinzel, Smith, 1999 vers…
parameter: 686007
parameter: 685992
parameter: 686008
parameter: 685976
units def: 914178
parameter: 686026
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685968
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value: 21.0
name: C

914154
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914166
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scale: -12
multipler: 1.0
kind: FARAD

685978
type: Parameter
constant: false
units: dimensionless
value: NaN
name: m_infinity

686021
type: Parameter
constant: false
units: 914103
value: NaN
name: i_NaP

914103
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name: picoA

914116
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: AMPERE

686012
type: Parameter
constant: true
units: 914055
value: 10.0
name: tau_n_max

914055
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name: millisecond

914067
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scale: -3
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kind: SECOND

685996
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name: omega_n

914079
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name: millivolt

914091
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scale: -3
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kind: VOLT

686003
type: Parameter
constant: true
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value: 11.2
name: g_K

914128
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name: nanoS

914141
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kind: SIEMENS

685972
type: Parameter
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units: 914103
value: NaN
name: i_Na

686041
type: Parameter
constant: true
units: 914079
value: 6.0
name: omega_h

685933
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

686017
type: Parameter
constant: true
units: 914079
value: NaN
name: V

685986
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name: n

686000
type: Parameter
constant: true
units: 914055
value: NaN
name: time

686032
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units: dimensionless
value: NaN
name: h

686037
type: Parameter
constant: true
units: 914055
value: 10000.0
name: tau_h_max

686014
type: Parameter
constant: true
units: 914079
value: -29.0
name: theta_n

686052
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units: 914103
value: NaN
name: i_tonic_e

686035
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units: 914055
value: NaN
name: tau_h

686045
type: Parameter
constant: true
units: 914055
value: NaN
name: time

686028
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constant: true
units: 914079
value: -6.0
name: omega_m

685982
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units: 914079
value: -5.0
name: omega_m

686043
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686019
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914190
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685988
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units: dimensionless
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name: n_infinity

685998
type: Parameter
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name: V

685980
type: Parameter
constant: true
units: 914079
value: -34.0
name: theta_m

685990
type: Parameter
constant: false
units: 914055
value: NaN
name: tau_n

686039
type: Parameter
constant: true
units: 914079
value: -48.0
name: theta_h

686049
type: Parameter
constant: true
units: 914128
value: 2.8
name: g_L

685974
type: Parameter
constant: true
units: 914079
value: 50.0
name: E_Na

686033
type: Parameter
constant: false
units: dimensionless
value: NaN
name: h_infinity

686051
type: Parameter
constant: true
units: 914079
value: -65.0
name: E_L

685967
type: Parameter
constant: false
units: 914079
value: NaN
name: V

686056
type: Parameter
constant: true
units: 914079
value: 0.0
name: E_syn_e

686010
type: Parameter
constant: false
units: 914055
value: NaN
name: tau_n

686015
type: Parameter
constant: true
units: 914079
value: -4.0
name: omega_n

686025
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units: dimensionless
value: NaN
name: m_infinity

686054
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value: 0.0
name: g_tonic_e

686047
type: Parameter
constant: false
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value: NaN
name: i_L

685984
type: Parameter
constant: true
units: 914079
value: NaN
name: V

685994
type: Parameter
constant: true
units: 914079
value: -29.0
name: theta_n

686001
type: Parameter
constant: false
units: 914103
value: NaN
name: i_K

686030
type: Parameter
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units: 914079
value: NaN
name: V

686023
type: Parameter
constant: true
units: 914128
value: 2.8
name: g_NaP

686006
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value: -85.0
name: E_K

685970
type: Parameter
constant: true
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value: 0.0
name: i_app

686007
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constant: false
units: dimensionless
value: NaN
name: n

685992
type: Parameter
constant: true
units: 914055
value: 10.0
name: tau_n_max

686008
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constant: false
units: dimensionless
value: NaN
name: n_infinity

685976
type: Parameter
constant: true
units: 914128
value: 28.0
name: g_Na

686026
type: Parameter
constant: true
units: 914079
value: -40.0
name: theta_m