MODEL7817907010
type: SBMLModel
parameter: 103806
parameter: 103846
parameter: 103852
parameter: 103668
units def: 891436
notes: This a model from the article: Riluzole-induced block of voltage-gated Na+ current and activation of BKCa channels in cultured differentiated human skeletal muscle cells. Wang YJ, Lin MW, Lin AA, Wu SN. Life Sci. (2008) 82(1-2) pp 11-20; Pubmed ID: 18068197 , Abstract: Riluzole is known to be of therapeutic use in the management of amyotrophic lateral sclerosis. In this study, we investigated the effects of riluzole on ion currents in cultured differentiated human skeletal muscle cells (dHSkMCs). Western blotting revealed the protein expression of alpha-subunits for both large-conductance Ca2+-activated K+ (BK(Ca)) channel and Na+ channel (Na(v)1.5) in these cells. Riluzole could reduce the frequency of spontaneous beating in dHSkMCs. In whole-cell configuration, riluzole suppressed voltage-gated Na+ current (I(Na)) in a concentration-dependent manner with an IC50 value of 2.3 microM. Riluzole (10 microM) also effectively increased Ca2+-activated K+ current (I(K(Ca))) which could be reversed by iberiotoxin (200 nM) and paxilline (1 microM), but not by apamin (200 nM). In inside-out patches, when applied to the inside of the cell membrane, riluzole (10 microM) increased BK(Ca)-channel activity with a decrease in mean closed time. Simulation studies also unraveled that both decreased conductance of I(Na) and increased conductance of I(K(Ca)) utilized to mimic riluzole actions in skeletal muscle cells could combine to decrease the amplitude of action potentials and increase the repolarization of action potentials. Taken together, inhibition of I(Na) and stimulation of BK(Ca)-channel activity caused by this drug are partly, if not entirely, responsible for its muscle relaxant actions in clinical setting. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Wang_Lin_Lin_Wu, 1999, version02 The original CellML model was created by: Nunns, Geoffrey, Rogan gnunns1(at)jhem.jhu.edu The University of Auckland Auckland Bio…
parameter: 103682
rule: 103644
parameter: 103674
compartment: 103577
parameter: 103832
rule: 103614
parameter: 103794
parameter: 103786
parameter: 103800
parameter: 103840
rule: 103640
parameter: 103748
parameter: 103766
rule: 103610
parameter: 103662
parameter: 103780
parameter: 103820
parameter: 103838
units def: 891161
parameter: 103716
parameter: 103774
units def: 891137
parameter: 103818
parameter: 103696
parameter: 103736
parameter: 103742
parameter: 103760
parameter: 103808
rule: 103632
rule: 103598
rule: 103602
parameter: 103722
parameter: 103684
parameter: 103676
units def: 891052
parameter: 103812
parameter: 103834
parameter: 103690
parameter: 103730
rule: 103594
units def: 891472
parameter: 103802
parameter: 103670
parameter: 103710
parameter: 103728
parameter: 103798
parameter: 103768
units def: 891276
parameter: 103664
parameter: 103782
parameter: 103822
parameter: 103708
rule: 103646
name: Wang2008_Rilusole_SkeletalMuscleCells
rule: 103608
parameter: 103738
time units: 891472
rule: 103586
area units: area
parameter: 103770
parameter: 103762
units def: 891089
parameter: 103754
parameter: 103724
is described by: http://identifiers.org/pubmed/18068197
rule: 103582
rule: 103638
parameter: 103814
units def: 891250
rule: 103628
parameter: 103688
parameter: 103658
parameter: 103804

103806
type: Parameter
constant: true
units: 891113
value: 50.0
name: E_Ca

891113
type: SBMLUnitsDef
unit: 891125
name: millivolt

891125
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: VOLT

103846
type: Parameter
constant: true
units: 891113
value: 40.0
name: V_beta_n

103852
type: Parameter
constant: true
units: 891328
value: 0.0229
name: alpha_n_max

891328
type: SBMLUnitsDef
unit: 891352
unit: 891340
name: per_millivolt_per_millisecond

891352
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: VOLT

891340
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND

103668
type: Parameter
constant: true
units: 891089
value: 6.0
name: t_1

891089
type: SBMLUnitsDef
unit: 891101
name: millisecond

891101
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND

891436
type: SBMLUnitsDef
unit: 891460
unit: 891448
name: nanosiemens_per_millivolt

891460
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: VOLT

891448
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: SIEMENS

103682
type: Parameter
constant: true
units: 891089
value: NaN
name: time

103674
type: Parameter
constant: false
units: 891161
value: NaN
name: I_Na

891161
type: SBMLUnitsDef
unit: 891174
name: picoampere

891174
type: SBMLUnit
exponent: 1.0
scale: -12
multipler: 1.0
kind: AMPERE

103577
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

103832
type: Parameter
constant: true
units: 891224
value: 0.415
name: g_K

891224
type: SBMLUnitsDef
unit: 891237
name: nanosiemens

891237
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: SIEMENS

103794
type: Parameter
constant: true
units: 891186
value: 0.01
name: f_er

891186
type: SBMLUnitsDef
unit: 891211
unit: 891198
name: per_picoampere_per_millisecond

891211
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND

891198
type: SBMLUnit
exponent: -1.0
scale: -12
multipler: 1.0
kind: AMPERE

103786
type: Parameter
constant: true
units: dimensionless
value: 4.5E-6
name: alpha

103800
type: Parameter
constant: false
units: 891161
value: NaN
name: I_Ca

103840
type: Parameter
constant: true
units: 891113
value: -40.0
name: E_n

103748
type: Parameter
constant: false
units: 891276
value: NaN
name: beta_Vm

891276
type: SBMLUnitsDef
unit: 891289
name: per_millisecond

891289
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND

103766
type: Parameter
constant: false
units: dimensionless
value: NaN
name: w

103662
type: Parameter
constant: false
units: 891161
value: NaN
name: I_stim

103780
type: Parameter
constant: false
units: 891161
value: NaN
name: j_leak

103820
type: Parameter
constant: false
units: dimensionless
value: NaN
name: d_infinity

103838
type: Parameter
constant: true
units: 891113
value: NaN
name: V_m

103716
type: Parameter
constant: true
units: 891276
value: 0.0156
name: alpha_h_max

103774
type: Parameter
constant: false
units: dimensionless
value: 0.15
name: c

891137
type: SBMLUnitsDef
unit: 891149
name: picofarad

891149
type: SBMLUnit
exponent: 1.0
scale: -12
multipler: 1.0
kind: FARAD

103818
type: Parameter
constant: false
units: 891089
value: NaN
name: tau_d

103696
type: Parameter
constant: true
units: 891328
value: 0.208
name: alpha_m_max

103736
type: Parameter
constant: false
units: dimensionless
value: 0.15
name: o

103742
type: Parameter
constant: true
units: dimensionless
value: NaN
name: c

103760
type: Parameter
constant: true
units: 891276
value: 0.48
name: a_bar

103808
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: d

103722
type: Parameter
constant: true
units: 891250
value: 15.0
name: R_s

891250
type: SBMLUnitsDef
unit: 891263
name: per_nanosiemens

891263
type: SBMLUnit
exponent: -1.0
scale: -9
multipler: 1.0
kind: SIEMENS

103684
type: Parameter
constant: true
units: 891113
value: NaN
name: V_m

103676
type: Parameter
constant: true
units: 891224
value: 0.45
name: g_Na

891052
type: SBMLUnitsDef
unit: 891076
unit: 891064
name: kilocoulombs_per_mole

891076
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE

891064
type: SBMLUnit
exponent: 1.0
scale: 3
multipler: 1.0
kind: COULOMB

103812
type: Parameter
constant: true
units: 891089
value: NaN
name: time

103834
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: n

103690
type: Parameter
constant: true
units: 891113
value: 18.0
name: V_beta_m

103730
type: Parameter
constant: true
units: 891113
value: NaN
name: V_m

891472
type: SBMLUnitsDef
unit: 891485
name: time

891485
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND

103802
type: Parameter
constant: false
units: 891224
value: NaN
name: g_Ca

103670
type: Parameter
constant: false
units: dimensionless
value: NaN
name: H_0

103710
type: Parameter
constant: true
units: 891113
value: 7.6
name: V_beta_h

103728
type: Parameter
constant: true
units: 891089
value: NaN
name: time

103798
type: Parameter
constant: true
units: dimensionless
value: 5.0
name: v_cytver

103768
type: Parameter
constant: true
units: 891089
value: NaN
name: time

103664
type: Parameter
constant: true
units: 891161
value: 2.0
name: I_mag

103782
type: Parameter
constant: false
units: 891161
value: NaN
name: j_serca

103822
type: Parameter
constant: false
units: 891161
value: NaN
name: I_L

103708
type: Parameter
constant: true
units: 891113
value: 14.7
name: V_alpha_h

103738
type: Parameter
constant: true
units: 891089
value: NaN
name: time

103770
type: Parameter
constant: true
units: dimensionless
value: 0.18
name: kd

103762
type: Parameter
constant: true
units: 891276
value: 0.28
name: b_bar

103754
type: Parameter
constant: true
units: dimensionless
value: 1.0
name: d_2

103724
type: Parameter
constant: true
units: 891137
value: 0.04
name: C_t

103814
type: Parameter
constant: false
units: 891276
value: NaN
name: alpha_d

103688
type: Parameter
constant: true
units: 891113
value: 10.0
name: V_alpha_m

103658
type: Parameter
constant: false
units: 891113
value: -75.0
name: V_m

103804
type: Parameter
constant: true
units: 891436
value: 0.05
name: g_Ca0

103672
type: Parameter
constant: false
units: dimensionless
value: NaN
name: H_1

103712
type: Parameter
constant: false
units: 891276
value: NaN
name: alpha_h

891302
type: SBMLUnitsDef
unit: 891315
name: per_millivolt

891315
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: VOLT

103830
type: Parameter
constant: true
units: 891113
value: -70.0
name: E_K

103655
type: Parameter
constant: true
units: 891364
value: 2577.0
name: RT

891364
type: SBMLUnitsDef
unit: 891388
unit: 891376
name: joule_per_mole

891388
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE

891376
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: JOULE

103660
type: Parameter
constant: true
units: 891137
value: 0.009
name: C_m

103810
type: Parameter
constant: true
units: 891113
value: NaN
name: V_m

891400
type: SBMLUnitsDef
unit: 891424
unit: 891412
name: kilojoule_per_mole

891424
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE

891412
type: SBMLUnit
exponent: 1.0
scale: 3
multipler: 1.0
kind: JOULE

103764
type: Parameter
constant: true
units: 891364
value: NaN
name: RT

103848
type: Parameter
constant: false
units: 891276
value: NaN
name: alpha_n

103704
type: Parameter
constant: true
units: 891113
value: NaN
name: V_m

103756
type: Parameter
constant: true
units: dimensionless
value: 0.18
name: k_1

103726
type: Parameter
constant: false
units: 891113
value: -70.0
name: V_T

103816
type: Parameter
constant: false
units: 891276
value: NaN
name: beta_d

103828
type: Parameter
constant: false
units: 891161
value: NaN
name: I_K

103714
type: Parameter
constant: false
units: 891276
value: NaN
name: beta_h

103854
type: Parameter
constant: true
units: 891276
value: 0.09616
name: beta_n_max

103750
type: Parameter
constant: false
units: 891089
value: NaN
name: tau_Vm

103720
type: Parameter
constant: false
units: 891161
value: NaN
name: I_T

103700
type: Parameter
constant: false
units: dimensionless
value: 1.0
name: h

103788
type: Parameter
constant: true
units: dimensionless
value: 0.2
name: k_pmca

103842
type: Parameter
constant: true
units: 891113
value: -24.6
name: E_d

103796
type: Parameter
constant: true
units: 891186
value: 0.01
name: f_cyt

103706
type: Parameter
constant: true
units: 891113
value: -41.0
name: E_h

103718
type: Parameter
constant: true
units: 891276
value: 3.382
name: beta_h_max

103758
type: Parameter
constant: true
units: dimensionless
value: 0.011
name: k_2

103776
type: Parameter
constant: false
units: dimensionless
value: 200.0
name: cer

103790
type: Parameter
constant: true
units: 891161
value: 0.4
name: k_serca

103744
type: Parameter
constant: false
units: dimensionless
value: NaN
name: o_oinf

103698
type: Parameter
constant: true
units: 891276
value: 2.081
name: beta_m_max

103752
type: Parameter
constant: true
units: dimensionless
value: 0.84
name: d_1

103678
type: Parameter
constant: true
units: 891113
value: 50.0
name: E_Na

103824
type: Parameter
constant: true
units: 891113
value: -75.0
name: E_L

103692
type: Parameter
constant: false
units: 891276
value: NaN
name: alpha_m

103732
type: Parameter
constant: false
units: 891161
value: NaN
name: I_KCa

103702
type: Parameter
constant: true
units: 891089
value: NaN
name: time

103686
type: Parameter
constant: true
units: 891113
value: -42.0
name: E_m

103844
type: Parameter
constant: true
units: 891113
value: 7.0
name: V_alpha_n

103850
type: Parameter
constant: false
units: 891276
value: NaN
name: beta_n

103666
type: Parameter
constant: true
units: 891089
value: 5.0
name: t_0

103680
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: m

103778
type: Parameter
constant: false
units: 891161
value: NaN
name: j_mem

103792
type: Parameter
constant: true
units: 891161
value: 5.0E-4
name: p_leak

103784
type: Parameter
constant: false
units: 891161
value: NaN
name: j_er

103746
type: Parameter
constant: false
units: 891276
value: NaN
name: alpha_Vm

103836
type: Parameter
constant: true
units: 891089
value: NaN
name: time

103772
type: Parameter
constant: true
units: dimensionless
value: NaN
name: c

103826
type: Parameter
constant: true
units: 891224
value: 0.0024
name: g_Lmax

103694
type: Parameter
constant: false
units: 891276
value: NaN
name: beta_m

103734
type: Parameter
constant: true
units: 891224
value: 0.5
name: g_KCa

103740
type: Parameter
constant: true
units: 891113
value: NaN
name: V_m