MODEL4992089662
type: SBMLModel
species: metaid mATP
species: metaid eHy
reaction: 110247
parameter: 106786
species: metaid gluc
species: metaid ATP
area units: area
species: 106677
time units: 013121
species: metaid eL
substance units: 106194
reaction: 109250
reaction: 107399
reaction: 109593
species: metaid K
units def: 106386
species: metaid NAD
curated: false
reaction: 110477
species: metaid mFADH
reaction: 108464
species: metaid AMP
reaction: 108354
species: metaid eO2
units def: 106471
units def: 106218
species: metaid eAd
reaction: 110067
species: metaid CO2
species: metaid Ox
species: metaid Phos
species: metaid Ad
is: http://identifiers.org/taxonomy/9606
species: metaid mCO2
species: metaid PCr
species: metaid Na
reaction: 110187
species: metaid Cr
parameter: 106726
parameter: 106750
rule: 106834
species: metaid mNAD
reaction: 109044
reaction: 109946
species: metaid mADP
reaction: 109788
species: metaid eBiC
reaction: 110007
parameter: 106798
species: metaid ADP
name: Banaji2005_Brain_Cell_Metabolism
reaction: 108634
reaction: 107897
species: metaid eNa
reaction: 107825
units def: 106314
reaction: 109358
species: metaid ePy0
reaction: 109716
species: metaid L0
species: metaid mO2
rule: 106846
species: metaid lac
species: metaid mBiC
compartment: metaid Vol ecs
reaction: 108875
units def: 106194
species: metaid BiC
species: metaid Py0
reaction: 109467
reaction: 107026
species: metaid mPhos
reaction: 108078
species: metaid egluc
species: metaid suc
parameter: 106774
species: metaid mNADH
reaction: 108706
reaction: 107691

metaid mATP
type: Species
constant: false
in compartment: metaid Vol inm
has only substance units: false
is: SBO:0000247
initial concentration: 14.1732283464567
is: CHEBI:15422
name: ATP
boundary condition: false
initial amount: NaN

metaid Vol inm
type: Compartment
is: GO:0005759
constant: true
size: 0.08
spatial dimensions: 3.0
name: mitochondrial matrix

metaid eHy
type: Species
has only substance units: false
in compartment: metaid Vol ecs
name: hydrogen ion
boundary condition: true
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:15378
initial concentration: 5.623413252E-5

metaid Vol ecs
type: Compartment
is: GO:0005576
constant: true
size: 0.2
spatial dimensions: 3.0
name: extracellular

110247
type: Reaction
kinetic law: 110284
product: 110272
reactant: 110259
is: SBO:0000185
fast: false
reversible: true
name: potassium diffusion

110296
type: LocalParameter
units: 106314
value: 0.00110055857788

106314
type: SBMLUnitsDef
unit: 106338
unit: 106326
name: litre per second

106338
type: SBMLUnit
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND

106326
type: SBMLUnit
exponent: 1.0
scale: 1
multipler: 1.0
kind: LITRE

110272
type: SpeciesReference
stoichiometry: 1.0
species: metaid K

metaid K
type: Species
constant: false
boundary condition: false
name: potassium ion
has only substance units: false
is: SBO:0000247
initial concentration: 180.0
is: CHEBI:29103
initial amount: NaN
in compartment: metaid Vol exm

metaid Vol exm
type: Compartment
is: GO:0005737
constant: true
size: 0.72
spatial dimensions: 3.0
name: cytoplasm

110259
type: SpeciesReference
stoichiometry: 1.0
species: metaid eK

metaid eK
type: Species
is: CHEBI:29103
name: potassium ion
in compartment: metaid Vol ecs
constant: false
initial concentration: 2.8
initial amount: NaN
is: SBO:0000247
boundary condition: true
has only substance units: false

106786
type: Parameter
constant: false
units: 106507
value: NaN

106507
type: SBMLUnitsDef
unit: 106519
name: millivolt

106519
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: VOLT

metaid gluc
type: Species
boundary condition: false
has only substance units: false
name: glucose
initial concentration: 1.4
in compartment: metaid Vol exm
is: SBO:0000247
is: CHEBI:17234
constant: false
initial amount: NaN

metaid ATP
type: Species
has only substance units: false
is: CHEBI:15422
initial concentration: 3.0
initial amount: NaN
is: SBO:0000247
name: ATP
boundary condition: false
constant: false
in compartment: metaid Vol exm

106677
type: Species
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: metaid Vol exm
name: sites on cellular proteins bound to protons

metaid eL
type: Species
name: lactic acid
initial concentration: 7.7505304385E-4
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: true
in compartment: metaid Vol ecs
is: CHEBI:28358
has only substance units: false

106206
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

109250
type: Reaction
is: SBO:0000185
fast: false
kinetic law: 109310
name: pyruvate transport
reactant: 109262
product: 109286
reversible: true
product: 109298
reactant: 109274

109346
type: LocalParameter
units: dimensionless
value: 0.5

109334
type: LocalParameter
units: 106218
value: 5.3997401390841E-6

106218
type: SBMLUnitsDef
unit: 106254
unit: 106242
unit: 106230
name: litre millimolar cubed per second

106254
type: SBMLUnit
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND

106242
type: SBMLUnit
exponent: -2.0
scale: 1
multipler: 1.0
kind: LITRE

106230
type: SBMLUnit
exponent: 3.0
scale: -3
multipler: 1.0
kind: MOLE

109322
type: LocalParameter
units: 106435
value: 1.372460087E-5

106435
type: SBMLUnitsDef
unit: 106459
unit: 106447
name: millimolar squared

106459
type: SBMLUnit
exponent: -2.0
scale: 1
multipler: 1.0
kind: LITRE

106447
type: SBMLUnit
exponent: 2.0
scale: -3
multipler: 1.0
kind: MOLE

109262
type: SpeciesReference
stoichiometry: 1.0
species: metaid Py0

metaid Py0
type: Species
in compartment: metaid Vol exm
initial concentration: 0.12
initial amount: NaN
name: pyruvate
is: SBO:0000247
boundary condition: false
is: CHEBI:15361
constant: false
has only substance units: false

109286
type: SpeciesReference
stoichiometry: 1.0
species: metaid mPy0

metaid mPy0
type: Species
name: pyruvate
is: SBO:0000247
boundary condition: false
initial concentration: 0.38218288373136
has only substance units: false
initial amount: NaN
is: CHEBI:15361
constant: false
in compartment: metaid Vol inm

109298
type: SpeciesReference
stoichiometry: 1.0
species: metaid mHy

metaid mHy
type: Species
constant: false
initial amount: NaN
name: hydrogen ion
is: SBO:0000247
is: CHEBI:15378
initial concentration: 2.13796209E-5
has only substance units: false
boundary condition: false
in compartment: metaid Vol inm

109274
type: SpeciesReference
stoichiometry: 1.0
species: metaid Hy

metaid Hy
type: Species
boundary condition: false
initial amount: NaN
in compartment: metaid Vol exm
constant: false
is: CHEBI:15378
has only substance units: false
is: SBO:0000247
name: hydrogen ion
initial concentration: 8.511380382E-5

107399
type: Reaction
reactant: 107411
fast: false
product: 107447
reactant: 107435
product: 107472
name: final stages of the TCA cycle
reactant: 107423
kinetic law: 107496
product: 107484
product: 107459
is: SBO:0000176
reversible: true

107411
type: SpeciesReference
stoichiometry: 1.0
species: metaid suc

metaid suc
type: Species
in compartment: metaid Vol inm
is: CHEBI:15741
initial concentration: 0.1
constant: false
name: succinate
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

107447
type: SpeciesReference
stoichiometry: 1.0
species: metaid Ox

metaid Ox
type: Species
boundary condition: false
in compartment: metaid Vol inm
has only substance units: false
is: CHEBI:16452
initial concentration: 0.54
constant: false
name: oxaloacetate
is: SBO:0000247
initial amount: NaN

107435
type: SpeciesReference
stoichiometry: 1.0
species: metaid mFAD

metaid mFAD
type: Species
initial concentration: 0.1
in compartment: metaid Vol inm
name: FAD
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16238

107472
type: SpeciesReference
stoichiometry: 1.0
species: metaid mHy

107423
type: SpeciesReference
stoichiometry: 1.0
species: metaid mNAD

metaid mNAD
type: Species
constant: false
name: NAD
boundary condition: false
is: CHEBI:15846
initial amount: NaN
in compartment: metaid Vol inm
initial concentration: 9.09090909090909
has only substance units: false
is: SBO:0000247

107545
type: LocalParameter
units: 106386
value: 1.3809705

106386
type: SBMLUnitsDef
unit: 106423
unit: 106411
unit: 106399
name: millimolar per second

106423
type: SBMLUnit
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND

106411
type: SBMLUnit
exponent: -1.0
scale: 1
multipler: 1.0
kind: LITRE

106399
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

107533
type: LocalParameter
units: 106350
value: 0.3

106350
type: SBMLUnitsDef
unit: 106374
unit: 106362
name: millimolar

106374
type: SBMLUnit
exponent: -1.0
scale: 1
multipler: 1.0
kind: LITRE

106362
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

107520
type: LocalParameter
units: 106350
value: 0.45454545454546

107508
type: LocalParameter
units: 106350
value: 0.1

107484
type: SpeciesReference
stoichiometry: 1.0
species: metaid mFADH

metaid mFADH
type: Species
constant: false
in compartment: metaid Vol inm
initial amount: NaN
initial concentration: 1.22
has only substance units: false
is: SBO:0000247
name: FADH2
is: CHEBI:17877
boundary condition: false

107459
type: SpeciesReference
stoichiometry: 1.0
species: metaid mNADH

metaid mNADH
type: Species
boundary condition: false
is: CHEBI:16908
in compartment: metaid Vol inm
is: SBO:0000247
initial concentration: 0.90909090909091
constant: false
has only substance units: false
initial amount: NaN
name: NADH

109593
type: Reaction
kinetic law: 109632
product: 109619
reactant: 109606
is: SBO:0000185
fast: false
reversible: true
name: oxygen diffusion

109644
type: LocalParameter
units: 106314
value: 1.73434285714286

109619
type: SpeciesReference
stoichiometry: 1.0
species: metaid mO2

metaid mO2
type: Species
initial amount: NaN
constant: false
has only substance units: false
in compartment: metaid Vol inm
name: oxygen
is: CHEBI:15379
initial concentration: 0.02275
is: SBO:0000247
boundary condition: false

109606
type: SpeciesReference
stoichiometry: 1.0
species: metaid O2

metaid O2
type: Species
initial concentration: 0.0455
constant: false
initial amount: NaN
name: oxygen
is: CHEBI:15379
has only substance units: false
in compartment: metaid Vol exm
boundary condition: false
is: SBO:0000247

metaid NAD
type: Species
is: CHEBI:15846
in compartment: metaid Vol exm
initial concentration: 0.2970297029703
name: NAD
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false

110477
type: Reaction
kinetic law: 110513
product: 110501
reactant: 110489
is: SBO:0000185
fast: false
reversible: true
name: lactic acid diffusion

110525
type: LocalParameter
units: 106314
value: 0.0401243

110501
type: SpeciesReference
stoichiometry: 1.0
species: metaid lac

metaid lac
type: Species
constant: false
name: lactic acid
is: CHEBI:28358
has only substance units: false
is: SBO:0000247
boundary condition: false
in compartment: metaid Vol exm
initial amount: NaN
initial concentration: 0.0012335333887

110489
type: SpeciesReference
stoichiometry: 1.0
species: metaid eL

108464
type: Reaction
kinetic law: 108513
product: 108501
product: 108488
reactant: 108476
is: SBO:0000176
fast: false
reversible: true
name: non-pumping ATP use

108537
type: LocalParameter
units: 106386
value: 0.14897283194444

108525
type: LocalParameter
units: 106350
value: 0.3

108501
type: SpeciesReference
stoichiometry: 1.0
species: metaid Phos

metaid Phos
type: Species
is: CHEBI:43474
has only substance units: false
name: inorganic phosphate
initial amount: NaN
constant: false
in compartment: metaid Vol exm
initial concentration: 1.5
is: SBO:0000247
boundary condition: false

108488
type: SpeciesReference
stoichiometry: 1.0
species: metaid ADP

metaid ADP
type: Species
name: ADP
is: CHEBI:16761
is: SBO:0000247
initial amount: NaN
initial concentration: 0.35
in compartment: metaid Vol exm
has only substance units: false
boundary condition: false
constant: false

108476
type: SpeciesReference
stoichiometry: 1.0
species: metaid ATP

metaid AMP
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
in compartment: metaid Vol exm
name: AMP
initial concentration: 0.11366534740545
is: CHEBI:16027
is: SBO:0000247

108354
type: Reaction
fast: false
reactant: 108366
is: SBO:0000176
reversible: true
name: PCr to ATP interconversion
reactant: 108379
reactant: 108391
product: 108403
product: 108416
kinetic law: 108428

108366
type: SpeciesReference
stoichiometry: 1.0
species: metaid PCr

metaid PCr
type: Species
in compartment: metaid Vol exm
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:17287
initial concentration: 5.85
name: phosphocreatine
initial amount: NaN

108379
type: SpeciesReference
stoichiometry: 1.0
species: metaid ADP

108391
type: SpeciesReference
stoichiometry: 1.0
species: metaid Hy

108403
type: SpeciesReference
stoichiometry: 1.0
species: metaid Cr

metaid Cr
type: Species
is: CHEBI:16919
has only substance units: false
name: creatine
initial amount: NaN
in compartment: metaid Vol exm
initial concentration: 3.9
boundary condition: false
constant: false
is: SBO:0000247

108416
type: SpeciesReference
stoichiometry: 1.0
species: metaid ATP

108452
type: LocalParameter
units: 106531
value: 2.521086835E-5

106531
type: SBMLUnitsDef
unit: 106568
unit: 106555
unit: 106543
name: per millimolar per second

106568
type: SBMLUnit
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND

106555
type: SBMLUnit
exponent: 1.0
scale: 1
multipler: 1.0
kind: LITRE

106543
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE

108440
type: LocalParameter
units: 106580
value: 1.69258214789161

106580
type: SBMLUnitsDef
unit: 106616
unit: 106604
unit: 106592
name: per millimolar squared per second

106616
type: SBMLUnit
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND

106604
type: SBMLUnit
exponent: 2.0
scale: 1
multipler: 1.0
kind: LITRE

106592
type: SBMLUnit
exponent: -2.0
scale: -3
multipler: 1.0
kind: MOLE

metaid eO2
type: Species
initial concentration: 0.05
initial amount: NaN
in compartment: metaid Vol ecs
has only substance units: false
is: SBO:0000247
boundary condition: true
name: oxygen
is: CHEBI:15379
constant: false

106471
type: SBMLUnitsDef
unit: 106495
unit: 106483
name: millimole per second

106495
type: SBMLUnit
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND

106483
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

metaid eAd
type: Species
constant: false
in compartment: metaid Vol ecs
boundary condition: true
name: adenosine
initial concentration: 1.0E-5
is: SBO:0000247
is: CHEBI:16335
initial amount: NaN
has only substance units: false

110067
type: Reaction
kinetic law: 110103
product: 110091
reactant: 110079
is: SBO:0000185
fast: false
reversible: true
name: CO2 diffusion

110115
type: LocalParameter
units: 106314
value: 0.14712903673276

110091
type: SpeciesReference
stoichiometry: 1.0
species: metaid CO2

metaid CO2
type: Species
name: carbon dioxide
initial amount: NaN
in compartment: metaid Vol exm
boundary condition: false
is: CHEBI:16526
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 2.052

110079
type: SpeciesReference
stoichiometry: 1.0
species: metaid eCO2

metaid eCO2
type: Species
in compartment: metaid Vol ecs
is: CHEBI:16526
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: 1.7838252
is: SBO:0000247
name: carbon dioxide
constant: false

metaid Ad
type: Species
has only substance units: false
constant: false
is: CHEBI:16335
is: SBO:0000247
initial concentration: 1.0E-5
in compartment: metaid Vol exm
boundary condition: false
name: adenosine
initial amount: NaN

metaid mCO2
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 2.4624
in compartment: metaid Vol inm
boundary condition: false
constant: false
is: SBO:0000247
name: carbon dioxide
is: CHEBI:16526

metaid Na
type: Species
initial concentration: 15.0
name: sodium ion
initial amount: NaN
is: CHEBI:29101
boundary condition: false
constant: false
is: SBO:0000247
in compartment: metaid Vol exm
has only substance units: false

110187
type: Reaction
kinetic law: 110223
product: 110211
reactant: 110199
is: SBO:0000185
fast: false
reversible: true
name: adenosine diffusion

110235
type: LocalParameter
units: 106314
value: 0.00180821003624

110211
type: SpeciesReference
stoichiometry: 1.0
species: metaid Ad

110199
type: SpeciesReference
stoichiometry: 1.0
species: metaid eAd

106726
type: Parameter
constant: true
units: 106507
value: 26.73

106750
type: Parameter
constant: false
units: 106507
value: NaN

109044
type: Reaction
kinetic law: 109092
product: 109080
product: 109068
reactant: 109056
is: SBO:0000176
fast: false
reversible: true
name: production and dissociation of carbonic acid

109117
type: LocalParameter
units: 106531
value: 74.4632928753754

109104
type: LocalParameter
units: 106653
value: 0.05882600137155

106653
type: SBMLUnitsDef
unit: 106665
name: per second

106665
type: SBMLUnit
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND

109080
type: SpeciesReference
stoichiometry: 1.0
species: metaid eBiC

metaid eBiC
type: Species
in compartment: metaid Vol ecs
name: bicarbonate ion
is: CHEBI:17544
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000247
initial concentration: 25.0599030317216
constant: false

109068
type: SpeciesReference
stoichiometry: 1.0
species: metaid eHy

109056
type: SpeciesReference
stoichiometry: 1.0
species: metaid eCO2

109946
type: Reaction
kinetic law: 109982
product: 109970
reactant: 109958
is: SBO:0000185
fast: false
reversible: true
name: glucose transport

109994
type: LocalParameter
units: 106314
value: 0.00982672403768

109970
type: SpeciesReference
stoichiometry: 1.0
species: metaid gluc

109958
type: SpeciesReference
stoichiometry: 1.0
species: metaid egluc

metaid egluc
type: Species
name: glucose
in compartment: metaid Vol ecs
constant: false
is: CHEBI:17234
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: true
initial concentration: 2.08792

metaid mADP
type: Species
initial concentration: 0.82677165354331
has only substance units: false
in compartment: metaid Vol inm
is: SBO:0000247
name: ADP
constant: false
initial amount: NaN
is: CHEBI:16761
boundary condition: false

109788
type: Reaction
fast: false
reactant: 109800
reversible: true
kinetic law: 109885
reactant: 109812
product: 109861
reactant: 109824
name: active sodium potassium exchange
is: SBO:0000185
product: 109837
product: 109849
product: 109873

109800
type: SpeciesReference
stoichiometry: 1.0
species: metaid ATP

109934
type: LocalParameter
units: 106471
value: 0.7293709852

109921
type: LocalParameter
units: dimensionless
value: 0.21739130434783

109909
type: LocalParameter
units: dimensionless
value: 0.01088888888889

109897
type: LocalParameter
units: 106350
value: 1.4

109812
type: SpeciesReference
stoichiometry: 2.0
species: metaid eK

109861
type: SpeciesReference
stoichiometry: 2.0
species: metaid K

109824
type: SpeciesReference
stoichiometry: 3.0
species: metaid Na

109837
type: SpeciesReference
stoichiometry: 1.0
species: metaid ADP

109849
type: SpeciesReference
stoichiometry: 1.0
species: metaid Phos

109873
type: SpeciesReference
stoichiometry: 3.0
species: metaid eNa

metaid eNa
type: Species
initial concentration: 138.0
is: SBO:0000247
in compartment: metaid Vol ecs
constant: false
boundary condition: true
name: sodium ion
initial amount: NaN
has only substance units: false
is: CHEBI:29101

110007
type: Reaction
kinetic law: 110043
product: 110031
reactant: 110019
is: SBO:0000185
fast: false
reversible: true
name: oxygen diffusion

110055
type: LocalParameter
units: 106314
value: 8.76806666666666

110031
type: SpeciesReference
stoichiometry: 1.0
species: metaid O2

110019
type: SpeciesReference
stoichiometry: 1.0
species: metaid eO2

106798
type: Parameter
constant: false
units: 106386
value: NaN

108634
type: Reaction
kinetic law: 108670
product: 108658
reactant: 108646
is: SBO:0000176
fast: false
reversible: true
name: AMP degradation

108694
type: LocalParameter
units: 106653
value: 0.01386172409053

108682
type: LocalParameter
units: 106653
value: 1.2195206724773E-6

108658
type: SpeciesReference
stoichiometry: 1.0
species: metaid Ad

108646
type: SpeciesReference
stoichiometry: 1.0
species: metaid AMP

107897
type: Reaction
reactant: 107933
is: SBO:0000176
fast: false
reactant: 107921
product: 107945
product: 107957
kinetic law: 107970
reversible: true
reactant: 107909
name: oxidative phosphorylation

107933
type: SpeciesReference
stoichiometry: 3.0
species: metaid Hy

107921
type: SpeciesReference
stoichiometry: 1.0
species: metaid mPhos

metaid mPhos
type: Species
constant: false
boundary condition: false
is: SBO:0000247
name: inorganic phosphate
in compartment: metaid Vol inm
is: CHEBI:43474
initial amount: NaN
has only substance units: false
initial concentration: 3.2

107945
type: SpeciesReference
stoichiometry: 1.0
species: metaid mATP

107957
type: SpeciesReference
stoichiometry: 3.0
species: metaid mHy

108066
type: LocalParameter
units: 106653
value: 4.585E-14

108054
type: LocalParameter
units: 106653
value: 9.651E-14

108042
type: LocalParameter
units: 106653
value: 1.656E-5

108030
type: LocalParameter
units: dimensionless
value: 6.65E-15

108018
type: LocalParameter
units: dimensionless
value: 7.739E-7

108006
type: LocalParameter
units: dimensionless
value: 1.346E-8

107994
type: LocalParameter
units: 106350
value: -34.9815865155365

107982
type: LocalParameter
units: dimensionless
value: 1710000.0

107909
type: SpeciesReference
stoichiometry: 1.0
species: metaid mADP

107825
type: Reaction
kinetic law: 107861
product: 107849
reactant: 107837
is: SBO:0000185
fast: false
reversible: true
name: proton leak

107885
type: LocalParameter
units: 106628
value: 0.038

106628
type: SBMLUnitsDef
unit: 106641
name: per millivolt

106641
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: VOLT

107873
type: LocalParameter
units: 106471
value: 6.278528285E-5

107849
type: SpeciesReference
stoichiometry: 1.0
species: metaid mHy

107837
type: SpeciesReference
stoichiometry: 1.0
species: metaid Hy

109358
type: Reaction
product: 109394
fast: false
name: phosphate transport
kinetic law: 109418
is: SBO:0000185
product: 109406
reversible: true
reactant: 109382
reactant: 109370

109394
type: SpeciesReference
stoichiometry: 1.0
species: metaid mPhos

109454
type: LocalParameter
units: dimensionless
value: 0.5

109442
type: LocalParameter
units: 106218
value: 0.00186561232274

109430
type: LocalParameter
units: 106435
value: 4.7876514649E-4

109406
type: SpeciesReference
stoichiometry: 1.0
species: metaid mHy

109382
type: SpeciesReference
stoichiometry: 1.0
species: metaid Hy

109370
type: SpeciesReference
stoichiometry: 1.0
species: metaid Phos

metaid ePy0
type: Species
initial concentration: 0.12
boundary condition: true
is: CHEBI:15361
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
in compartment: metaid Vol ecs
name: pyruvate

109716
type: Reaction
kinetic law: 109752
product: 109740
reactant: 109728
is: SBO:0000185
fast: false
reversible: true
name: bicarbonate transport

109776
type: LocalParameter
units: 106314
value: 1.646537405E-5

109764
type: LocalParameter
units: 106314
value: 7.865980171E-5

109740
type: SpeciesReference
stoichiometry: 1.0
species: metaid mBiC

metaid mBiC
type: Species
initial concentration: 90.9883299405421
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:17544
name: bicarbonate ion
in compartment: metaid Vol inm
initial amount: NaN

109728
type: SpeciesReference
stoichiometry: 1.0
species: metaid BiC

metaid BiC
type: Species
in compartment: metaid Vol exm
initial amount: NaN
is: CHEBI:17544
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 19.0460292836137
name: bicarbonate ion

metaid L0
type: Species
constant: false
is: SBO:0000247
in compartment: metaid Vol exm
initial amount: NaN
name: lactate
is: CHEBI:24996
initial concentration: 2.0
has only substance units: false
boundary condition: false

108875
type: Reaction
kinetic law: 108923
product: 108911
product: 108899
reactant: 108887
is: SBO:0000176
fast: false
reversible: true
name: general buffer reaction

108947
type: LocalParameter
units: 106531
value: 678.647439710924

108935
type: LocalParameter
units: 106653
value: 0.28881132523331

108911
type: SpeciesReference
stoichiometry: 1.0
species: metaid Hy

108899
type: SpeciesReference
stoichiometry: 1.0
species: 106689

106689
type: Species
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: metaid Vol exm
name: sites on cellular proteins capable of binding protons

108887
type: SpeciesReference
stoichiometry: 1.0
species: 106677

109467
type: Reaction
reactant: 109479
product: 109516
kinetic law: 109528
fast: false
product: 109504
name: ATP-ADP antiport
is: SBO:0000185
reversible: true
reactant: 109492

109479
type: SpeciesReference
stoichiometry: 1.0
species: metaid ADP

109516
type: SpeciesReference
stoichiometry: 1.0
species: metaid mADP

109580
type: LocalParameter
units: dimensionless
value: 7.2

109567
type: LocalParameter
units: dimensionless
value: 0.1111

109554
type: LocalParameter
units: dimensionless
value: 0.8

109541
type: LocalParameter
units: 106386
value: 493.779692845496

109504
type: SpeciesReference
stoichiometry: 1.0
species: metaid ATP

109492
type: SpeciesReference
stoichiometry: 1.0
species: metaid mATP

107026
type: Reaction
reversible: true
product: 107074
name: PDH reaction plus first stages of the TCA cycle
fast: false
product: 107111
reactant: 107038
product: 107086
modifier: 107123
is: SBO:0000176
reactant: 107062
product: 107099
reactant: 107050
kinetic law: 107135

107074
type: SpeciesReference
stoichiometry: 1.0
species: metaid AKG

metaid AKG
type: Species
constant: false
initial amount: NaN
in compartment: metaid Vol inm
initial concentration: 0.1
boundary condition: false
is: CHEBI:16810
name: alpha-ketoglutarate
has only substance units: false
is: SBO:0000247

107111
type: SpeciesReference
stoichiometry: 1.0
species: metaid mHy

107038
type: SpeciesReference
stoichiometry: 1.0
species: metaid mPy0

107086
type: SpeciesReference
stoichiometry: 2.0
species: metaid mCO2

107062
type: SpeciesReference
stoichiometry: 2.0
species: metaid mNAD

107099
type: SpeciesReference
stoichiometry: 2.0
species: metaid mNADH

107050
type: SpeciesReference
stoichiometry: 1.0
species: metaid Ox

107195
type: LocalParameter
units: 106386
value: 0.19657949068328

107183
type: LocalParameter
units: 106350
value: 0.03821828837314

107171
type: LocalParameter
units: 106350
value: 6.4E-4

107159
type: LocalParameter
units: 106350
value: 0.90909090909091

107147
type: LocalParameter
units: 106350
value: 0.062

108078
type: Reaction
kinetic law: 108126
product: 108114
product: 108102
reactant: 108090
is: SBO:0000176
fast: false
reversible: true
name: production and dissociation of carbonic acid

108150
type: LocalParameter
units: 106531
value: 34.1712886402221

108138
type: LocalParameter
units: 106653
value: 0.02699531802578

108114
type: SpeciesReference
stoichiometry: 1.0
species: metaid mBiC

108102
type: SpeciesReference
stoichiometry: 1.0
species: metaid mHy

108090
type: SpeciesReference
stoichiometry: 1.0
species: metaid mCO2

106774
type: Parameter
constant: true
units: dimensionless
value: 0.6

108706
type: Reaction
kinetic law: 108754
product: 108742
product: 108730
reactant: 108718
is: SBO:0000176
fast: false
reversible: true
name: lactic acid dissociation

108778
type: LocalParameter
units: 106531
value: 167323.655549796

108766
type: LocalParameter
units: 106653
value: 23090.6644658719

108742
type: SpeciesReference
stoichiometry: 1.0
species: metaid Hy

108730
type: SpeciesReference
stoichiometry: 1.0
species: metaid L0

108718
type: SpeciesReference
stoichiometry: 1.0
species: metaid lac

107691
type: Reaction
name: oxidation of FADH2
reversible: true
kinetic law: 107763
reactant: 107703
product: 107751
reactant: 107715
is: SBO:0000176
product: 107739
fast: false
reactant: 107727

107812
type: LocalParameter
units: 106471
value: 0.041429115

107800
type: LocalParameter
units: 106350
value: 0.0011375

107788
type: LocalParameter
units: dimensionless
value: 0.25118864315096

107776
type: LocalParameter
units: dimensionless
value: 24.4

107703
type: SpeciesReference
stoichiometry: 2.0
species: metaid mFADH

107751
type: SpeciesReference
stoichiometry: 16.0
species: metaid Hy

107715
type: SpeciesReference
stoichiometry: 1.0
species: metaid mO2

107739
type: SpeciesReference
stoichiometry: 2.0
species: metaid mFAD

107727
type: SpeciesReference
stoichiometry: 16.0
species: metaid mHy

106858
type: Reaction
product: 106930
is: SBO:0000176
product: 106918
reversible: true
product: 106954
reactant: 106894
reactant: 106906
fast: false
kinetic law: 106966
reactant: 106870
reactant: 106882
product: 106942
name: glycolysis in one step

106930
type: SpeciesReference
stoichiometry: 2.0
species: metaid Py0

106918
type: SpeciesReference
stoichiometry: 2.0
species: metaid NADH

metaid NADH
type: Species
is: CHEBI:16908
initial amount: NaN
constant: false
name: NADH
has only substance units: false
initial concentration: 0.0029702970297
boundary condition: false
in compartment: metaid Vol exm
is: SBO:0000247

106954
type: SpeciesReference
stoichiometry: 2.0
species: metaid ATP

106894
type: SpeciesReference
stoichiometry: 2.0
species: metaid ADP

106906
type: SpeciesReference
stoichiometry: 2.0
species: metaid Phos

107014
type: LocalParameter
units: 106350
value: 0.05

107002
type: LocalParameter
units: 106350
value: 0.3

106990
type: LocalParameter
units: 106350
value: 1.0

106978
type: LocalParameter
units: 106350
value: 0.07

106870
type: SpeciesReference
stoichiometry: 1.0
species: metaid gluc

106882
type: SpeciesReference
stoichiometry: 2.0
species: metaid NAD

106942
type: SpeciesReference
stoichiometry: 4.0
species: metaid Hy

110127
type: Reaction
kinetic law: 110163
product: 110151
reactant: 110139
is: SBO:0000185
fast: false
reversible: true
name: pyruvate diffusion

110175
type: LocalParameter
units: 106314
value: 108.4926021746

110151
type: SpeciesReference
stoichiometry: 1.0
species: metaid Py0

110139
type: SpeciesReference
stoichiometry: 1.0
species: metaid ePy0

110308
type: Reaction
kinetic law: 110344
product: 110332
reactant: 110320
is: SBO:0000185
fast: false
reversible: true
name: sodium diffusion

110356
type: LocalParameter
units: 106314
value: 0.0023782802439

110332
type: SpeciesReference
stoichiometry: 1.0
species: metaid Na

110320
type: SpeciesReference
stoichiometry: 1.0
species: metaid eNa

106738
type: Parameter
constant: true
units: dimensionless
value: 3.0

106762
type: Parameter
constant: true
units: 106507
value: 150.0

106810
type: Parameter
constant: true
units: 106386
value: 0.12973000591182

110368
type: Reaction
fast: false
name: lactate transport
product: 110404
is: SBO:0000185
reactant: 110392
kinetic law: 110428
product: 110416
reactant: 110380
reversible: true

110404
type: SpeciesReference
stoichiometry: 1.0
species: metaid L0

110392
type: SpeciesReference
stoichiometry: 1.0
species: metaid eHy

110464
type: LocalParameter
units: dimensionless
value: 0.5

110452
type: LocalParameter
units: 106218
value: 5.10346312866496E-7

110440
type: LocalParameter
units: 106435
value: 1.1490363516E-4

110416
type: SpeciesReference
stoichiometry: 1.0
species: metaid Hy

110380
type: SpeciesReference
stoichiometry: 1.0
species: metaid eL0

metaid eL0
type: Species
boundary condition: true
initial amount: NaN
in compartment: metaid Vol ecs
has only substance units: false
is: CHEBI:24996
is: SBO:0000247
constant: false
initial concentration: 1.902
name: lactate

W3 CDTF: Fri Feb 03 11:12:16 GMT 2012

109656
type: Reaction
kinetic law: 109692
product: 109680
reactant: 109668
is: SBO:0000185
fast: false
reversible: true
name: CO2 diffusion

109704
type: LocalParameter
units: 106314
value: 0.09614108187134

109680
type: SpeciesReference
stoichiometry: 1.0
species: metaid mCO2

109668
type: SpeciesReference
stoichiometry: 1.0
species: metaid CO2

108790
type: Reaction
kinetic law: 108838
product: 108826
product: 108814
reactant: 108802
is: SBO:0000176
fast: false
reversible: true
name: production and dissociation of carbonic acid

108863
type: LocalParameter
units: 106531
value: 247.520371612693

108850
type: LocalParameter
units: 106653
value: 0.19554109357403

108826
type: SpeciesReference
stoichiometry: 1.0
species: metaid BiC

108814
type: SpeciesReference
stoichiometry: 1.0
species: metaid Hy

108802
type: SpeciesReference
stoichiometry: 1.0
species: metaid CO2

107557
type: Reaction
product: 107606
reactant: 107569
product: 107618
reversible: true
reactant: 107593
is: SBO:0000176
name: oxidation of NADH
reactant: 107581
kinetic law: 107630
fast: false

107606
type: SpeciesReference
stoichiometry: 2.0
species: metaid mNAD

107569
type: SpeciesReference
stoichiometry: 2.0
species: metaid mNADH

107618
type: SpeciesReference
stoichiometry: 20.0
species: metaid Hy

107593
type: SpeciesReference
stoichiometry: 22.0
species: metaid mHy

107581
type: SpeciesReference
stoichiometry: 1.0
species: metaid mO2

107679
type: LocalParameter
units: 106471
value: 0.63086721428571

107667
type: LocalParameter
units: 106350
value: 0.05

107655
type: LocalParameter
units: dimensionless
value: 0.2

107643
type: LocalParameter
units: dimensionless
value: 0.25118864315096

ORG:
  orgname: University of Manchester
n:
  given: Kieran
  family: Smallbone

106701
type: Parameter
constant: true
units: 106350
value: 0.11366534740545

108959
type: Reaction
kinetic law: 109008
product: 108996
product: 108984
reactant: 108972
is: SBO:0000176
fast: false
reversible: true
name: lactic acid dissociation

109032
type: LocalParameter
units: 106531
value: 167323.655549796

109020
type: LocalParameter
units: 106653
value: 23090.6644658719

108996
type: SpeciesReference
stoichiometry: 1.0
species: metaid eHy

108984
type: SpeciesReference
stoichiometry: 1.0
species: metaid eL0

108972
type: SpeciesReference
stoichiometry: 1.0
species: metaid eL

107207
type: Reaction
reactant: 107255
kinetic law: 107327
reactant: 107243
name: middle stages of the TCA cycle
reversible: true
product: 107279
is: SBO:0000176
product: 107315
product: 107303
fast: false
product: 107267
product: 107291
reactant: 107219
reactant: 107231

107255
type: SpeciesReference
stoichiometry: 1.0
species: metaid mPhos

107387
type: LocalParameter
units: 106386
value: 3.4721544

107375
type: LocalParameter
units: 106350
value: 0.64

107363
type: LocalParameter
units: 106350
value: 27.2727272727273

107351
type: LocalParameter
units: 106350
value: 0.08267716535433

107339
type: LocalParameter
units: 106350
value: 0.3

107243
type: SpeciesReference
stoichiometry: 1.0
species: metaid mADP

107279
type: SpeciesReference
stoichiometry: 1.0
species: metaid suc

107315
type: SpeciesReference
stoichiometry: 1.0
species: metaid mATP

107303
type: SpeciesReference
stoichiometry: 1.0
species: metaid mHy

107267
type: SpeciesReference
stoichiometry: 1.0
species: metaid mCO2

107291
type: SpeciesReference
stoichiometry: 1.0
species: metaid mNADH

107219
type: SpeciesReference
stoichiometry: 1.0
species: metaid AKG

107231
type: SpeciesReference
stoichiometry: 1.0
species: metaid mNAD

ORG:
  orgname: University of Essex
n:
  given: Murad
  family: Banaji

ORG:
  orgname: University of Essex
n:
  given: Murad
  family: Banaji

108162
type: Reaction
kinetic law: 108234
name: lactate to pyruvate interconversion
reactant: 108198
reversible: true
reactant: 108186
product: 108222
reactant: 108174
is: SBO:0000176
product: 108210
fast: false

108294
type: LocalParameter
units: 106350
value: 0.0062

108330
type: LocalParameter
units: dimensionless
value: 0.43536879122666

108318
type: LocalParameter
units: 106350
value: 0.034

108342
type: LocalParameter
units: 106386
value: 0.05586005108025

108270
type: LocalParameter
units: 106435
value: 0.24

108282
type: LocalParameter
units: 106350
value: 0.03

108246
type: LocalParameter
units: 106350
value: 1.7022760764E-4

108306
type: LocalParameter
units: 106435
value: 3.4E-5

108258
type: LocalParameter
units: 106350
value: 2.0

108198
type: SpeciesReference
stoichiometry: 1.0
species: metaid Hy

108186
type: SpeciesReference
stoichiometry: 1.0
species: metaid NADH

108222
type: SpeciesReference
stoichiometry: 1.0
species: metaid NAD

108174
type: SpeciesReference
stoichiometry: 1.0
species: metaid Py0

108210
type: SpeciesReference
stoichiometry: 1.0
species: metaid L0

109129
type: Reaction
reactant: 109153
product: 109190
is: SBO:0000185
product: 109178
reactant: 109165
reactant: 109141
product: 109202
kinetic law: 109214
reversible: true
name: malate-aspartate shuttle
fast: false

109153
type: SpeciesReference
stoichiometry: 1.0
species: metaid Hy

109190
type: SpeciesReference
stoichiometry: 1.0
species: metaid mHy

109178
type: SpeciesReference
stoichiometry: 1.0
species: metaid mNADH

109165
type: SpeciesReference
stoichiometry: 1.0
species: metaid mNAD

109141
type: SpeciesReference
stoichiometry: 1.0
species: metaid NADH

109202
type: SpeciesReference
stoichiometry: 1.0
species: metaid NAD

109238
type: LocalParameter
units: 106266
value: 1000.0

106266
type: SBMLUnitsDef
unit: 106302
unit: 106290
unit: 106278
name: litre per millimolar squared per second

106302
type: SBMLUnit
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND

106290
type: SBMLUnit
exponent: 3.0
scale: 1
multipler: 1.0
kind: LITRE

106278
type: SBMLUnit
exponent: -2.0
scale: -3
multipler: 1.0
kind: MOLE

109226
type: LocalParameter
units: 106266
value: 10000.0

108549
type: Reaction
kinetic law: 108598
product: 108586
product: 108574
reactant: 108561
is: SBO:0000176
fast: false
reversible: true
name: adenlyate kinase reaction

108622
type: LocalParameter
units: 106531
value: 379.0

108610
type: LocalParameter
units: 106531
value: 1055.0

108586
type: SpeciesReference
stoichiometry: 1.0
species: metaid AMP

108574
type: SpeciesReference
stoichiometry: 1.0
species: metaid ATP

108561
type: SpeciesReference
stoichiometry: 2.0
species: metaid ADP

ORG:
  orgname: University of Manchester
n:
  given: Kieran
  family: Smallbone

106714
type: Parameter
constant: true
units: 106350
value: 3.0

W3 CDTF: Fri Feb 03 11:12:16 GMT 2012

ORG:
  orgname: University of Manchester
n:
  given: Kieran
  family: Smallbone

W3 CDTF: Fri Feb 03 11:12:16 GMT 2012

W3 CDTF: Fri Feb 03 11:12:16 GMT 2012

W3 CDTF: Fri Dec 05 00:00:00 GMT 2008

ORG:
  orgname: University of Essex
n:
  given: Murad
  family: Banaji