MODEL4968912141
type: SBMLModel
length unit: length
reaction: 458606
species: 458526
species: 458506
reaction: 458566
units def: 099605
units def: 099520
is described by: http://identifiers.org/pubmed/12667087
units def: 099557
name: Phillips2003_RasGTPase
species: 458466
notes: Ras is an important regulator of cell growth in all eukaryotic cells. The model represent hydrolysis of active Ras-bound GTP to give inactive Ras-bound GDP catalyzed by GTPase activating proteins i.e NF1. The inactive Ras-bound GDP turns signalling off. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
volume units: metaid_0000217
time units: 013121
compartment: 458387
compartment: 458388
species: 458446
reaction: 458646
species: 458546
species: 458486
substance units: 099605
species: 458406
reaction: 458626
species: 458426
reaction: 458586
area units: area
curated: false

458606
type: Reaction
kinetic law: 099786
product: 099774
reactant: 099762
notes: Activation of Ras by GAP (i.e NF1) Kf = 418 /sec Kb = 5.5 /sec Table 3, Phillips RA et al 2003 Biochemistry 3956-3965
fast: false
reversible: true

099786
type: KineticLaw
local parameters: 099810
local parameters: 099798
notes: kf*RasGTP_minus_NF1-kb*RasGTP_minus_NF1_star_

099810
type: LocalParameter
units: 099520
value: 2.8798E-12

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exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

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type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

099798
type: LocalParameter
units: 099520
value: 2.188648E-10

099774
type: SpeciesReference
stoichiometry: 1.0
species: 458466

458466
type: Species
constant: false
boundary condition: false
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initial concentration: 0.0
initial amount: NaN
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458388
type: Compartment
constant: true
size: 5.236E-13
spatial dimensions: 3.0

099762
type: SpeciesReference
stoichiometry: 1.0
species: 458446

458446
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 458388

458526
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 458388

458506
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 458388

458566
type: Reaction
kinetic law: 099654
product: 099642
reactant: 099629
notes: First step in hydrolysis of GTP bound to Ras complexed with NF1 - a mammalian GAP Kf = 19.5 /sec Kb = 0.22 /sec Table 3, Phillips RA et al 2003 Biochemistry 3956-3965
fast: false
reversible: true

099654
type: KineticLaw
local parameters: 099678
local parameters: 099666
notes: kf*RasGTP_minus_NF1_star_-kb*RasGDP_minus_NF1_Pi

099678
type: LocalParameter
units: 099520
value: 1.15192E-13

099666
type: LocalParameter
units: 099520
value: 1.02102E-11

099642
type: SpeciesReference
stoichiometry: 1.0
species: 458486

458486
type: Species
constant: false
boundary condition: false
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initial amount: NaN
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species: 458466

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exponent: 1.0
scale: -6
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kind: MOLE

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scale: 0
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kind: SECOND

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type: SBMLUnit
exponent: -1.0
scale: -6
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kind: MOLE

099569
type: SBMLUnit
exponent: 2.0
scale: 0
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kind: LITRE

458387
type: Compartment
constant: true
size: 1.0E-18
spatial dimensions: 3.0

458646
type: Reaction
kinetic law: 099930
product: 099918
reactant: 099906
reactant: 099894
notes: Binding of NF1 to Ras.GTP NF1 is a mammalian GAP Kd = 5.3 uM Table 3, Phillips RA et al 2003 Biochemistry 3956-3965
fast: false
reversible: true

099930
type: KineticLaw
local parameters: 099954
local parameters: 099942
notes: kf*RasGTP*NF1-kb*RasGTP_minus_NF1

099954
type: LocalParameter
units: 099520
value: 3.330096E-12

099942
type: LocalParameter
units: 099557
value: 6.283184040672E-13

099918
type: SpeciesReference
stoichiometry: 1.0
species: 458446

099906
type: SpeciesReference
stoichiometry: 1.0
species: 458546

458546
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 9.99936338171632
initial amount: NaN
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099894
type: SpeciesReference
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species: 458426

458426
type: Species
constant: false
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initial concentration: 1.0
initial amount: NaN
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458406
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 458388

458626
type: Reaction
kinetic law: 099858
product: 099846
product: 099834
reactant: 099822
notes: Dissociation of NF1 from Ras.GDP NF1 is a mammalian GAP Kf = 46.5 /sec Kb = 1.2 /sec/uM Table 3, Phillips RA et al 2003 Biochemistry 3956-3965
fast: false
reversible: true

099858
type: KineticLaw
local parameters: 099882
local parameters: 099870
notes: kf*RasGDP_NF1-kb*RasGDP*NF1

099882
type: LocalParameter
units: 099557
value: 6.283184040672E-13

099870
type: LocalParameter
units: 099520
value: 2.43474E-11

099846
type: SpeciesReference
stoichiometry: 1.0
species: 458546

099834
type: SpeciesReference
stoichiometry: 1.0
species: 458526

099822
type: SpeciesReference
stoichiometry: 1.0
species: 458506

458586
type: Reaction
kinetic law: 099726
product: 099714
product: 099702
reactant: 099690
notes: Second step in hydrolysis of GTP bound to Ras is complexed with NF1 - a mammalian GAP Kf = 40 /sec Kb = 108 /M/sec = 1.08e-04 /uM/sec Phillips RA et al 2003 Biochemistry 3956-3965
fast: false
reversible: true

099726
type: KineticLaw
local parameters: 099750
local parameters: 099738
notes: kf*RasGDP_minus_NF1_Pi-kb*Pi*RasGDP_NF1

099750
type: LocalParameter
units: 099557
value: 5.654816288352E-17

099738
type: LocalParameter
units: 099520
value: 2.0944E-11

099714
type: SpeciesReference
stoichiometry: 1.0
species: 458506

099702
type: SpeciesReference
stoichiometry: 1.0
species: 458406

099690
type: SpeciesReference
stoichiometry: 1.0
species: 458486