MODEL4132046015
type: SBMLModel
species: 299650
species: 299309
reaction: 299880
reaction: 301256
reaction: 300510
species: 298851
reaction: 301340
reaction: 300044
species: 298937
reaction: 301261
reaction: 299948
species: 299745
species: 299678
reaction: 300741
reaction: 301138
species: 299587
species: 299077
reaction: 300312
reaction: 300732
reaction: 301224
species: 299175
reaction: 300578
species: 299681
species: 299000
species: 299808
reaction: 301154
reaction: 300371
species: 299230
reaction: 300725
reaction: 300562
species: 299157
reaction: 301215
reaction: 300140
reaction: 301208
reaction: 300133
reaction: 300012
species: 299832
reaction: 301045
reaction: 300425
species: 299741
species: 299534
reaction: 299884
reaction: 300618
reaction: 300616
reaction: 300094
reaction: 300364
reaction: 299893
reaction: 301106
species: 299031
species: 299171
species: 299726
reaction: 301199
species: 298861
reaction: 301016
reaction: 301007
reaction: 300546
reaction: 300539
species: 298967
species: 299300
species: 299332
species: 299259
reaction: 301281
reaction: 300418
species: 299472
reaction: 300255
reaction: 299877
species: 299108
reaction: 300623
species: 299188
reaction: 301122
reaction: 301115
species: 298974
species: 299761
species: 299027
species: 299608
species: 299013
species: 299527
reaction: 301023
reaction: 300309

299650
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: p68*

298802
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: genes

299309
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F5

298793
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: nucleus

299880
type: Reaction
product: 020220
reactant: 020208
reactant: 020196
notes: Competition between ARF and E2F1 to bind DP1. PMID: 16135794 ARF relocalize DP1 from the cytoplasm to the nucleolus PMID: 12446760
fast: false
reversible: false

020220
type: SpeciesReference
stoichiometry: 1.0
species: 299295

299295
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p14ARF*/DP1*

020208
type: SpeciesReference
stoichiometry: 1.0
species: 298849

298849
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p14ARF*

020196
type: SpeciesReference
stoichiometry: 1.0
species: 298827

298827
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: DP1*

298800
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: cell

301256
type: Reaction
product: 033686
reactant: 033674
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

033686
type: SpeciesReference
stoichiometry: 1.0
species: 299778

299778
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: UXT

033674
type: SpeciesReference
stoichiometry: 1.0
species: 299313

299313
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6

300510
type: Reaction
product: 027031
reactant: 027019
notes: PMID: 15897325
fast: false
reversible: false

027031
type: SpeciesReference
stoichiometry: 1.0
species: 299398

299398
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCAM

027019
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299840
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F1_alone

298851
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: a22_degraded

301340
type: Reaction
product: 034544
reactant: 034532
fast: false
reversible: false

034544
type: SpeciesReference
stoichiometry: 1.0
species: 299838

299838
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F3_alone

034532
type: SpeciesReference
stoichiometry: 1.0
species: 299337

299337
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F cofactors

300044
type: Reaction
product: 022334
reactant: 022321
notes: PMID: 12459251 PMID: 10385618 T286 phosphorylation promote association of cyclin D1 with its nuclear exporter CRM1, leading to cytoplasmic translocation of cylcin D1 PMID: 12851486
fast: false
reversible: false

022334
type: SpeciesReference
stoichiometry: 1.0
species: 299106

299106
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK6/cyclin D1*

022321
type: SpeciesReference
stoichiometry: 1.0
species: 299101

299101
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK6/cyclin D1*

298937
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p130*/E2F4/DP2*

301261
type: Reaction
product: 033734
reactant: 033722
notes: PMID: 16582100
fast: false
reversible: false

033734
type: SpeciesReference
stoichiometry: 1.0
species: 299780

299780
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BMI1

033722
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299948
type: Reaction
modifier: 021085
product: 021073
reactant: 021061
notes: PMID: 8380224 PMID: 9315635 PMID: 10773440
fast: false
reversible: false

298974
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: PP1

021073
type: SpeciesReference
stoichiometry: 1.0
species: 298810

298810
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*

021061
type: SpeciesReference
stoichiometry: 1.0
species: 298813

298813
type: Species
notes: Inhibition of E2F binding by phosphorylation at several of the 7 C-terminal sites or at one of the two serines 807 and 811. PMID : 9315635
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*

299745
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TP53INP1

299678
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ECE1

300741
type: Reaction
product: 029119
reactant: 029107
notes: Notes by CellDesigner PMID: 15731768
fast: false
reversible: false

029119
type: SpeciesReference
stoichiometry: 1.0
species: 299594

299594
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PPP1R13B

029107
type: SpeciesReference
stoichiometry: 1.0
species: 299843

299843
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F2_alone

301138
type: Reaction
product: 032606
reactant: 032594
notes: PMID: 15713665
fast: false
reversible: false

032606
type: SpeciesReference
stoichiometry: 1.0
species: 299699

299699
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: p27Kip*

032594
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299587
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RPL8

299077
type: Species
notes: molecular chaperone protein.
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: HSP90

300312
type: Reaction
product: 025431
reactant: 025419
notes: Nuclear translocation during the G2 to M transition. PMID: 8348613 Translocation via the proteins of the 14-3-3 group. PMID: 12814430 (ref REACTOME) PMID: 9836640 PMID: 9889122 (from REACTOME) PMID: 11063929
fast: false
reversible: false

025431
type: SpeciesReference
stoichiometry: 1.0
species: 299184

299184
type: Species
notes: Inactivated by CHEK1 and CHEK2 PMID: 12478465
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC25C

025419
type: SpeciesReference
stoichiometry: 1.0
species: 299182

299182
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC25C

300732
type: Reaction
product: 029023
reactant: 029011
notes: Notes by CellDesigner PMID: 12438307 reaction: direct
fast: false
reversible: false

029023
type: SpeciesReference
stoichiometry: 1.0
species: 299689

299689
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MYCN

029011
type: SpeciesReference
stoichiometry: 1.0
species: 299843

301224
type: Reaction
product: 033422
reactant: 033410
notes: PMID: 15044096
fast: false
reversible: false

033422
type: SpeciesReference
stoichiometry: 1.0
species: 299767

299767
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: WWOX

033410
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299175
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: cyclin B1*/CDC2

300578
type: Reaction
product: 027679
reactant: 027667
notes: PMID: 15897325
fast: false
reversible: false

027679
type: SpeciesReference
stoichiometry: 1.0
species: 299587

027667
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299681
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RRM2

299000
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: EZH2

299808
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p19INK4d*

301154
type: Reaction
product: 032750
reactant: 032738
notes: PMID: 15105421
fast: false
reversible: false

032750
type: SpeciesReference
stoichiometry: 1.0
species: 299715

299715
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SIVA

032738
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300371
type: Reaction
product: 026055
reactant: 026043
notes: PMID: 12389032
fast: false
reversible: false

026055
type: SpeciesReference
stoichiometry: 1.0
species: 299510

299510
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CASP9

026043
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299230
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK2/cyclin A2*/CDKN1B

300725
type: Reaction
product: 028951
reactant: 028939
notes: Notes by CellDesigner PMID: 16144839
fast: false
reversible: false

028951
type: SpeciesReference
stoichiometry: 1.0
species: 299554

299554
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MELK

028939
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300562
type: Reaction
product: 027511
reactant: 027499
notes: PMID: 15867358
fast: false
reversible: false

027511
type: SpeciesReference
stoichiometry: 1.0
species: 299552

299552
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PTGS2

027499
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299157
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin B1*/CDC2

301215
type: Reaction
product: 033326
reactant: 033314
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false

033326
type: SpeciesReference
stoichiometry: 1.0
species: 299763

299763
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TRIM55

033314
type: SpeciesReference
stoichiometry: 1.0
species: 298923

298923
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F4

300140
type: Reaction
modifier: 023342
product: 023330
reactant: 023318
notes: Dephosphorylation of CDC2 induces its activation. PMID: 10373560 PMID: 8348613 PMID: 12814430 (ref REACTOME) PMID: 10827953 PMID: 8440392 PMID: 15456846 PMID: 12524548 PMID: 8119945 PMID: 8428594 PMID: 15107615 PMID: 12411508
fast: false
reversible: false

023330
type: SpeciesReference
stoichiometry: 1.0
species: 299173

299173
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC2/cyclin B1*

023318
type: SpeciesReference
stoichiometry: 1.0
species: 299180

299180
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: cyclin B1*/CDC2

301208
type: Reaction
product: 033254
reactant: 033242
notes: PMID: 15897325
fast: false
reversible: false

033254
type: SpeciesReference
stoichiometry: 1.0
species: 299759

299759
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: UBB

033242
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300133
type: Reaction
product: 023270
reactant: 023258
notes: PMID: 10373560 The NES (Nuclear Export Signal) of cyclin B induces its active export. This export seems to be done via a CRM1 complex and could need the GTPaseRan/TC4. PMID: 9679058 (ref REACTOME) PMID: 9670027 PMID: 9679058
fast: false
reversible: false

023270
type: SpeciesReference
stoichiometry: 1.0
species: 299180

023258
type: SpeciesReference
stoichiometry: 1.0
species: 299164

299164
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin B1*/CDC2

300012
type: Reaction
product: 021913
reactant: 021901
reactant: 021889
notes: (ref REACTOME) PMID: 8078588 PMID: 8741839 PMID: 8001816 PMID: 8259215
fast: false
reversible: false

021913
type: SpeciesReference
stoichiometry: 1.0
species: 299060

299060
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK4/CDKN2B

021901
type: SpeciesReference
stoichiometry: 1.0
species: 299058

299058
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p15INK4b*

021889
type: SpeciesReference
stoichiometry: 1.0
species: 299056

299056
type: Species
notes: The native protein is first correctly folded by HSP90 and CDC37 before being able to bind to the D-type cyclins. PMID: 10385618 PMID: 10498883 (NF = non folded)
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK4

299832
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin A2*/CDK2/p130

301045
type: Reaction
product: 031717
reactant: 031705
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false

031717
type: SpeciesReference
stoichiometry: 1.0
species: 299525

299525
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PRKDC

031705
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300425
type: Reaction
product: 026527
reactant: 026515
notes: PMID: 11564866 PMID: 8441401
fast: false
reversible: false

026527
type: SpeciesReference
stoichiometry: 1.0
species: 299598

299598
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: DHFR

026515
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299741
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: STMN1

299534
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MTHFD1

299884
type: Reaction
product: 020256
reactant: 020244
reactant: 020232
notes: E2F1 sequestrated by ARF in the nucleolus. PMID: 16135794 PMID: 12446760
fast: false
reversible: false

020256
type: SpeciesReference
stoichiometry: 1.0
species: 298894

298894
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/p14ARF*

020244
type: SpeciesReference
stoichiometry: 1.0
species: 298849

020232
type: SpeciesReference
stoichiometry: 1.0
species: 298863

298863
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1

300618
type: Reaction
product: 028039
reactant: 028027
notes: Notes by CellDesigner PMID: 12771133 reaction: direct
fast: false
reversible: false

028039
type: SpeciesReference
stoichiometry: 1.0
species: 299427

299427
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDC2

028027
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300616
type: Reaction
product: 028015
reactant: 028003
notes: Notes by CellDesigner PMID: 12771133 reaction: direct
fast: false
reversible: false

028015
type: SpeciesReference
stoichiometry: 1.0
species: 299585

299585
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CCNB2

028003
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300094
type: Reaction
modifier: 022838
product: 022826
reactant: 022814
notes: CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin. PMID: 12814430 WEE1 allows CDC2 to stay in an inactive state after its translocation during G2. PMID: 10373560 PMID: 8348613 PMID: 9001210 (ref REACTOME) PMID: 1384126 PMID: 15037762
fast: false
reversible: false

299128
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: WEE1

022826
type: SpeciesReference
stoichiometry: 1.0
species: 299162

299162
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin B1*/CDC2

022814
type: SpeciesReference
stoichiometry: 1.0
species: 299157

300364
type: Reaction
product: 025983
reactant: 025971
notes: PMID: 12389032
fast: false
reversible: false

025983
type: SpeciesReference
stoichiometry: 1.0
species: 299604

299604
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CASP3

025971
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299893
type: Reaction
modifier: 020364
product: 020352
reactant: 020340
notes: PMID: 10753885
fast: false
reversible: false

298807
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: HDAC1

020352
type: SpeciesReference
stoichiometry: 1.0
species: 298877

298877
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/DP1*

020340
type: SpeciesReference
stoichiometry: 1.0
species: 298879

298879
type: Species
notes: active form
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/DP1*

301106
type: Reaction
product: 032294
reactant: 032282
notes: PMID: 12766778
fast: false
reversible: false

032294
type: SpeciesReference
stoichiometry: 1.0
species: 299667

299667
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TK1

032282
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299031
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: HP1gamma*/BAT8/EHMT1/_br_DP1*/MGA/E2F6/MAX

299171
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK7/cyclin H*/MNAT1

299726
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SNX19

301199
type: Reaction
product: 033182
reactant: 033170
notes: PMID: 15195143
fast: false
reversible: false

033182
type: SpeciesReference
stoichiometry: 1.0
species: 299750

299750
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TOPBP1

033170
type: SpeciesReference
stoichiometry: 1.0
species: 299840

298861
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: sa376_degraded

301016
type: Reaction
product: 031429
reactant: 031417
notes: Notes by CellDesigner PMID: 11564866 PMID: 12150994 reaction: direct
fast: false
reversible: false

031429
type: SpeciesReference
stoichiometry: 1.0
species: 299483

299483
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MYC

031417
type: SpeciesReference
stoichiometry: 1.0
species: 298923

301007
type: Reaction
product: 031333
reactant: 031321
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false

031333
type: SpeciesReference
stoichiometry: 1.0
species: 299539

299539
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MRPL27

031321
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300546
type: Reaction
product: 027367
reactant: 027355
notes: PMID: 12139485
fast: false
reversible: false

027367
type: SpeciesReference
stoichiometry: 1.0
species: 299572

299572
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PFKFB*

027355
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300539
type: Reaction
product: 027295
reactant: 027283
notes: PMID: 12665581
fast: false
reversible: false

027295
type: SpeciesReference
stoichiometry: 1.0
species: 299384

299384
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: NPAT

027283
type: SpeciesReference
stoichiometry: 1.0
species: 299840

298967
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK6/CDKN1A

299300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p14ARF*/MDM2

299332
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDKN3

299259
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p27Kip1*

301281
type: Reaction
product: 033926
reactant: 033914
notes: PMID: 16580749
fast: false
reversible: false

033926
type: SpeciesReference
stoichiometry: 1.0
species: 299786

299786
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDCA7

033914
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300418
type: Reaction
product: 026450
reactant: 026437
notes: PMID: 15313206
fast: false
reversible: false

026450
type: SpeciesReference
stoichiometry: 1.0
species: 299457

299457
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CSDA

026437
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299472
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CHEK2

300255
type: Reaction
reversible: false
modifier: 024758
reactant: 024734
product: 024746
notes: PMID: 15024084 ATM phosphorylates p53 in case of DNA double-strand breaks. ATR phosphorylates p53 in case of other types of DNA damages. PMID: 15140942 E2F1 stimulates ATM to phosphorylate p53 (and Chk2) PMID: 15140942 (ref REACTOME) PMID: 9843217 PMID: 9733515 PMID: 9733514
modifier: 024770
fast: false
modifier: 024782

298842
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CHEK2

024734
type: SpeciesReference
stoichiometry: 1.0
species: 299282

299282
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p53*

024746
type: SpeciesReference
stoichiometry: 1.0
species: 299284

299284
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p53*

298840
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: ATR

299293
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: ATM/NBS1

299877
type: Reaction
product: 020184
reactant: 020172
reactant: 020160
notes: Upon DNA damage and ATM phosphorylation, the transcriptional activity, the apoptotic and the S phase-inducing activites of E2F1 are inhibited by binding to TopBP1 (inhibition RB-independant). Induce damage repair. PMID: 15838517 PMID: 12697828
fast: false
reversible: false

020184
type: SpeciesReference
stoichiometry: 1.0
species: 298901

298901
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/DP1*/TopBP1

020172
type: SpeciesReference
stoichiometry: 1.0
species: 298854

298854
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: TOPBP1

020160
type: SpeciesReference
stoichiometry: 1.0
species: 298899

298899
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/DP1*

299108
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: cyclin D1*/CDK4

300623
type: Reaction
product: 028087
reactant: 028075
notes: Notes by CellDesigner PMID: 12004135 reaction: direct
fast: false
reversible: false

028087
type: SpeciesReference
stoichiometry: 1.0
species: 299507

299507
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDC25A

028075
type: SpeciesReference
stoichiometry: 1.0
species: 299313

299188
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC25C

301122
type: Reaction
product: 032462
reactant: 032450
notes: PMID: 11937641 PMID: 15210709
fast: false
reversible: false

032462
type: SpeciesReference
stoichiometry: 1.0
species: 299674

299674
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TP73

032450
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301115
type: Reaction
product: 032390
reactant: 032378
notes: PMID: 17471234
fast: false
reversible: false

032390
type: SpeciesReference
stoichiometry: 1.0
species: 299708

299708
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PAC1

032378
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299761
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TUBA3

299027
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: RYBP/RING1/BMI1*/_br_MEL-18*/PHC1

299608
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RQCD1

299013
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: EED

299527
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: POLA

301023
type: Reaction
product: 031501
reactant: 031489
notes: PMID: 12665581
fast: false
reversible: false

031501
type: SpeciesReference
stoichiometry: 1.0
species: 299384

031489
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300309
type: Reaction
product: 025407
reactant: 025395
notes: Phosphorylated CDC25 interacts with the 14-3-3 proteins which keep CDC25 outside of the nucleus. PMID: 12814430 PMID: 11313932 PMID: 11897663
fast: false
reversible: false

025407
type: SpeciesReference
stoichiometry: 1.0
species: 299318

299318
type: Species
notes: Needs verification: which form of CDC25 gets phosphorylated on Ser216 by Chek1,2???
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC25C

025395
type: SpeciesReference
stoichiometry: 1.0
species: 299304

299304
type: Species
notes: Needs verification: which form of CDC25 gets phosphorylated on Ser216 by Chek1,2???
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC25C

300854
type: Reaction
product: 029923
reactant: 029911
notes: Notes by CellDesigner PMID: 15510213 reaction: direct
fast: false
reversible: false

029923
type: SpeciesReference
stoichiometry: 1.0
species: 299378

299378
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PCNA

029911
type: SpeciesReference
stoichiometry: 1.0
species: 299838

299615
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: JPH2

299663
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F7

300691
type: Reaction
product: 028663
reactant: 028651
notes: Notes by CellDesigner PMID: 12077144
fast: false
reversible: false

028663
type: SpeciesReference
stoichiometry: 1.0
species: 299423

299423
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDKN2C

028651
type: SpeciesReference
stoichiometry: 1.0
species: 299843

299982
type: Reaction
product: 021517
reactant: 021505
reactant: 021493
notes: PMID: 15126619
fast: false
reversible: false

021517
type: SpeciesReference
stoichiometry: 1.0
species: 299038

299038
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: MAX/MGA

021505
type: SpeciesReference
stoichiometry: 1.0
species: 299009

299009
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: MAX

021493
type: SpeciesReference
stoichiometry: 1.0
species: 299007

299007
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: MGA

300514
type: Reaction
product: 027079
reactant: 027067
notes: PMID: 12909625
fast: false
reversible: false

027079
type: SpeciesReference
stoichiometry: 1.0
species: 299394

299394
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCM3

027067
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300684
type: Reaction
product: 028591
reactant: 028579
notes: PMID: 8618861
fast: false
reversible: false

028591
type: SpeciesReference
stoichiometry: 1.0
species: 299671

299671
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: Cyclin E*

028579
type: SpeciesReference
stoichiometry: 1.0
species: 299843

301337
type: Reaction
product: 034519
reactant: 034507
reactant: 034495
notes: p130 binds to and inhibits cyclinE-CDK2, independantly of its phosphorylation state. PMID: 15456871 PMID: 12006580 PMID: 11237530
fast: false
reversible: false

034519
type: SpeciesReference
stoichiometry: 1.0
species: 299834

299834
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*/CDK2/p130

034507
type: SpeciesReference
stoichiometry: 1.0
species: 298960

298960
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*/CDK2

034495
type: SpeciesReference
stoichiometry: 1.0
species: 298906

298906
type: Species
notes: Shuttling of p130 between the nucleus and cytoplasm PMID: 11756542
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p130*

299973
type: Reaction
product: 021421
reactant: 021409
fast: false
reversible: false

021421
type: SpeciesReference
stoichiometry: 1.0
species: 299029

299029
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6/DP2*

021409
type: SpeciesReference
stoichiometry: 1.0
species: 299040

299040
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F6/DP2*

300931
type: Reaction
product: 030613
reactant: 030601
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

030613
type: SpeciesReference
stoichiometry: 1.0
species: 299472

030601
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299757
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: UHRF1

300185
type: Reaction
modifier: 023906
product: 023894
reactant: 023882
notes: PMID: 11355576
fast: false
reversible: false

023894
type: SpeciesReference
stoichiometry: 1.0
species: 299193

299193
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK2

023882
type: SpeciesReference
stoichiometry: 1.0
species: 299200

299200
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK2

301097
type: Reaction
product: 032222
reactant: 032210
fast: false
reversible: false

032222
type: SpeciesReference
stoichiometry: 1.0
species: 299838

032210
type: SpeciesReference
stoichiometry: 1.0
species: 299661

299661
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F Family

300239
type: Reaction
product: 024578
reactant: 024566
reactant: 024554
notes: Inhibition of PCNA by p21. PMID: 12814430
fast: false
reversible: false

024578
type: SpeciesReference
stoichiometry: 1.0
species: 299266

299266
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: PCNA/CDKN1A

024566
type: SpeciesReference
stoichiometry: 1.0
species: 299825

299825
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p21Cip*

024554
type: SpeciesReference
stoichiometry: 1.0
species: 299261

299261
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: PCNA

300815
type: Reaction
product: 029803
reactant: 029791
notes: Notes by CellDesigner PMID: 8760872 reaction: direct PMID: 10766737PMID: 10733529
fast: false
reversible: false

029803
type: SpeciesReference
stoichiometry: 1.0
species: 299462

299462
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MYBL2

029791
type: SpeciesReference
stoichiometry: 1.0
species: 299838

299248
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: MNAT1

299845
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6/DP1*

301095
type: Reaction
product: 032198
reactant: 032186
fast: false
reversible: false

032198
type: SpeciesReference
stoichiometry: 1.0
species: 299843

032186
type: SpeciesReference
stoichiometry: 1.0
species: 299661

299754
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TOP2A

300530
type: Reaction
product: 027223
reactant: 027211
notes: PMID: 11564866 PMID: 90001421
fast: false
reversible: false

027223
type: SpeciesReference
stoichiometry: 1.0
species: 299483

027211
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301228
type: Reaction
product: 033446
reactant: 033434
fast: false
reversible: false

033446
type: SpeciesReference
stoichiometry: 1.0
species: 299770

299770
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ZNF83

033434
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300153
type: Reaction
modifier: 023522
product: 023510
reactant: 023498
notes: PMID: 16123593
fast: false
reversible: false

298805
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: APC/CDC20

023510
type: SpeciesReference
stoichiometry: 1.0
species: 299146

299146
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: a871_degraded

023498
type: SpeciesReference
stoichiometry: 1.0
species: 299144

299144
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin B1*

300025
type: Reaction
modifier: 022084
modifier: 022072
product: 022060
reactant: 022048
notes: All three Cip/Kip family members direct the accumulation of cylinD-CDK complexes in the nucleus. PMID: 10385618
fast: false
reversible: false

299088
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p27Kip1*

022060
type: SpeciesReference
stoichiometry: 1.0
species: 299097

299097
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK4

022048
type: SpeciesReference
stoichiometry: 1.0
species: 299117

299117
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: cyclin D1*/CDK4

299861
type: Reaction
modifier: 019980
product: 019968
reactant: 019956
notes: Phosphorylation of E2F1 leads to the end of transcription stimulation. PMID: 15840440 Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation). PMID: 15133492 PMID: 9556498 PMID: 15123636 Phosphorylation of both DP-1 and E2F1 PMID: 16135794 Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation. PMID: 11980909 Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb. PMID: 16213134
fast: false
reversible: false

298886
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin A2*/CDK2

019968
type: SpeciesReference
stoichiometry: 1.0
species: 298892

298892
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/DP1*/PCAF

019956
type: SpeciesReference
stoichiometry: 1.0
species: 298881

298881
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/DP1*/PCAF

299104
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK4

299966
type: Reaction
modifier: 021361
product: 021349
product: 021337
reactant: 021325
notes: pRB phosphorylation PMID: 9315635 PMID: 12006580 Brg1 phosphorylation PMID: 11420722 Brg1 (in the SWI/SNF complex) and pRB are phosphorylated, simultaneously with the complex dissociation. Phosphorylation of pRB PMID: 9315635 PMID: 12006580 Phosphorylation of Brg1 (SWI/SNF complex) PMID: 11420722
fast: false
reversible: false

021349
type: SpeciesReference
stoichiometry: 1.0
species: 298978

298978
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: SWI/SNF

021337
type: SpeciesReference
stoichiometry: 1.0
species: 298883

298883
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*/E2F1/DP1*

021325
type: SpeciesReference
stoichiometry: 1.0
species: 298987

298987
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*/E2F1/DP1*/SWI/SNF

300761
type: Reaction
product: 029275
reactant: 029263
notes: PMID: 15510213
fast: false
reversible: false

029275
type: SpeciesReference
stoichiometry: 1.0
species: 299559

299559
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: cyclin B1*

029263
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300214
type: Reaction
product: 024278
reactant: 024266
reactant: 024254
fast: false
reversible: false

024278
type: SpeciesReference
stoichiometry: 1.0
species: 298805

024266
type: SpeciesReference
stoichiometry: 1.0
species: 299142

299142
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC20

024254
type: SpeciesReference
stoichiometry: 1.0
species: 299237

299237
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: APC

300300
type: Reaction
modifier: 025311
product: 025299
reactant: 025287
notes: Phosphorylation at T145 is catalyzed by the protein serine/threonine kinase Akt PMID: 16775416 PMID: 15798220
fast: false
reversible: false

299198
type: Species
notes: UNIPROT: P31749 Q6ZS54 P55010 Q9BV07 Q9BWB6 Q6ZMW5 O15040 Q8TBZ3 P31749
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: AKT1

025299
type: SpeciesReference
stoichiometry: 1.0
species: 299818

299818
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p21Cip*

025287
type: SpeciesReference
stoichiometry: 1.0
species: 299825

299523
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PSMA4

301244
type: Reaction
product: 033614
reactant: 033602
notes: PMID: 12909625
fast: false
reversible: false

033614
type: SpeciesReference
stoichiometry: 1.0
species: 299778

033602
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300461
type: Reaction
product: 026815
reactant: 026803
notes: PMID: 15044096
fast: false
reversible: false

026815
type: SpeciesReference
stoichiometry: 1.0
species: 299490

299490
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: FHIT

026803
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301172
type: Reaction
product: 032942
reactant: 032930
notes: PMID: 15897325
fast: false
reversible: false

032942
type: SpeciesReference
stoichiometry: 1.0
species: 299736

299736
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SSR4

032930
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300566
type: Reaction
product: 027559
reactant: 027547
notes: PMID: 12909625
fast: false
reversible: false

027559
type: SpeciesReference
stoichiometry: 1.0
species: 299371

299371
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RBBP4

027547
type: SpeciesReference
stoichiometry: 1.0
species: 299840

298949
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p107*/E2F4/DP2*

299243
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK3

299936
type: Reaction
product: 020893
reactant: 020881
reactant: 020869
reactant: 020857
notes: HDAC1 and Sin3B associate to the promoteurs via E2F4 and p130/p107 PMID: 11959842 HDAC1 and SUV39H1 associate to the promoteurs via E2F4 and p130/p107 PMID: 15769944
fast: false
reversible: false

020893
type: SpeciesReference
stoichiometry: 1.0
species: 298953

298953
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p130*/E2F4/DP2*/_br_Sin3B/HDAC1/SUV39H1

020881
type: SpeciesReference
stoichiometry: 1.0
species: 298908

298908
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: SUV39H1

020869
type: SpeciesReference
stoichiometry: 1.0
species: 298937

020857
type: SpeciesReference
stoichiometry: 1.0
species: 298935

298935
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: Sin3B/HDAC1

299275
type: Species
notes: UNIPROT: Q13315 O00631 Q14964 Q8TDS3 Q8NG43 Q6TZ07 Q8NG45 Q8NG44 Q6TZ08 Q8NG42 Q8TDS2 Q5XKH5 Q6P7P1 Q8TDS0 Q96QM9 Q68DE6 Q7KYL7 Q8TDS1 O95727 Q6IRX2 Q9UPF7 P06401 Q12758 Q9NP02 Q9UCX7 Q13315 O15429 Q16551 Q93007 Q9BZC6 Q93034 O14766
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: ATM

299941
type: Reaction
modifier: 020953
modifier: 020941
product: 020917
notes: PMID: 12006580
modifier: 020929
modifier: 020965
reversible: false
reactant: 020905
fast: false
modifier: 020977

298965
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK4/CDKN1B

298962
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK6/CDKN1B

020917
type: SpeciesReference
stoichiometry: 1.0
species: 298951

298951
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p130*/E2F4/DP2*/_br_Sin3B/HDAC1/SUV39H1

020905
type: SpeciesReference
stoichiometry: 1.0
species: 298953

298971
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK4/CDKN1A

299367
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BUB1

301135
type: Reaction
product: 032582
reactant: 032570
notes: PMID: 12748276 PMID: 15574595
fast: false
reversible: false

032582
type: SpeciesReference
stoichiometry: 1.0
species: 299527

032570
type: SpeciesReference
stoichiometry: 1.0
species: 299838

298910
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p107*

301063
type: Reaction
product: 031885
reactant: 031873
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false

031885
type: SpeciesReference
stoichiometry: 1.0
species: 299610

299610
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RFC5

031873
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299687
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: H19

300454
type: Reaction
product: 026767
reactant: 026755
notes: PMID: 14532106
fast: false
reversible: false

026767
type: SpeciesReference
stoichiometry: 1.0
species: 299412

299412
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: EZH2

026755
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300198
type: Reaction
modifier: 024062
product: 024050
reactant: 024038
notes: Phosphorylation of p27 at Thr-157 by AKT-1 induce its cytoplasmic localization. PMID: 12851486 Phosphorylation of p21 at Thr-145 by AKT-1 induce its cytoplasmic localization. PMID: 11231573
fast: false
reversible: false

024050
type: SpeciesReference
stoichiometry: 1.0
species: 299221

299221
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p27Kip1*

024038
type: SpeciesReference
stoichiometry: 1.0
species: 299088

300121
type: Reaction
product: 023126
reactant: 023114
notes: PMID: 10373560 The NES (Nuclear Export Signal) of cyclin B induces its active export. This export seems to be done via a CRM1 complex and would need the GTPaseRan/TC4 PMID: 9679058 (ref REACTOME) PMID: 9670027 PMID: 9679058
fast: false
reversible: false

023126
type: SpeciesReference
stoichiometry: 1.0
species: 299175

023114
type: SpeciesReference
stoichiometry: 1.0
species: 299157

300445
type: Reaction
product: 026671
reactant: 026659
notes: PMID: 14633988
fast: false
reversible: false

026671
type: SpeciesReference
stoichiometry: 1.0
species: 299346

299346
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: E2F7

026659
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299044
type: Species
notes: Like CDK4, CDK6 has first to be folded by HSP90 and CDC37 before being able to bind D-type cyclins. PMID: 10385618 PMID: 10498883
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK6

299550
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MAD2L1

301070
type: Reaction
product: 031957
reactant: 031945
notes: Notes by CellDesigner PMID: 14688249 reaction: direct
fast: false
reversible: false

031957
type: SpeciesReference
stoichiometry: 1.0
species: 299681

031945
type: SpeciesReference
stoichiometry: 1.0
species: 298923

298870
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1

300797
type: Reaction
product: 029635
reactant: 029623
notes: Notes by CellDesigner PMID: 14532106 reaction: direct
fast: false
reversible: false

029635
type: SpeciesReference
stoichiometry: 1.0
species: 299412

029623
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300345
type: Reaction
product: 025815
reactant: 025803
notes: PMID: 15033491
fast: false
reversible: false

025815
type: SpeciesReference
stoichiometry: 1.0
species: 299518

299518
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: AURKB

025803
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301212
type: Reaction
product: 033302
reactant: 033290
notes: PMID: 15936277
fast: false
reversible: false

033302
type: SpeciesReference
stoichiometry: 1.0
species: 299761

033290
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300550
type: Reaction
product: 027415
reactant: 027403
notes: PMID: 16181749
fast: false
reversible: false

027415
type: SpeciesReference
stoichiometry: 1.0
species: 299373

299373
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PNRC2

027403
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301036
type: Reaction
product: 031621
reactant: 031609
notes: Notes by CellDesigner PMID: 15105433 reaction: directPMID: 15510213
fast: false
reversible: false

031621
type: SpeciesReference
stoichiometry: 1.0
species: 299529

299529
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PLK1

031609
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300979
type: Reaction
product: 031069
reactant: 031057
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false

031069
type: SpeciesReference
stoichiometry: 1.0
species: 299615

031057
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300000
type: Reaction
product: 021757
reactant: 021745
reactant: 021733
notes: PMID: 15536069
fast: false
reversible: false

021757
type: SpeciesReference
stoichiometry: 1.0
species: 299022

299022
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6/EPC1/Sin3B/EZH2/DP1*/EED

021745
type: SpeciesReference
stoichiometry: 1.0
species: 298931

298931
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: SIN3B

021733
type: SpeciesReference
stoichiometry: 1.0
species: 299018

299018
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6/DP1*/EPC1/EZH2/EED

301296
type: Reaction
product: 034070
reactant: 034058
fast: false
reversible: false

034070
type: SpeciesReference
stoichiometry: 1.0
species: 299814

299814
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: UDG1A

034058
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300527
type: Reaction
product: 027199
reactant: 027187
notes: PMID: 10766737 PMID: 8760872
fast: false
reversible: false

027199
type: SpeciesReference
stoichiometry: 1.0
species: 299462

027187
type: SpeciesReference
stoichiometry: 1.0
species: 299840

298903
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p130*

301043
type: Reaction
product: 031693
reactant: 031681
notes: Notes by CellDesigner PMID: 15711575 PMID: 12110166 reaction: direct
fast: false
reversible: false

031693
type: SpeciesReference
stoichiometry: 1.0
species: 299596

299596
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PPARG

031681
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299979
type: Reaction
product: 021481
reactant: 021469
reactant: 021457
notes: PMID: 15536069
fast: false
reversible: false

021481
type: SpeciesReference
stoichiometry: 1.0
species: 299016

299016
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6/DP1*/EPC1

021469
type: SpeciesReference
stoichiometry: 1.0
species: 298998

298998
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: EPC1

021457
type: SpeciesReference
stoichiometry: 1.0
species: 299845

299858
type: Reaction
modifier: 019920
modifier: 019932
notes: Acetylation of E2F1 (or activators E2Fs) on 3 lysine residues by PCAF increases its DNA-binding activity, stabilizes the protein and stimulates its transactivation potentiel. PMID: 15126619 Stabilisation of E2F1 by acetylation of Lys-117, Lys-120 and Lys-125 by PCAF and, to a lesser extent, p300 acetyltransferases. PMID: 15123636 Acetylated lysines on E2F1 are conserved and acetylated on E2F2 and E2F3. Acetylation by p300/CBP. PMID: 10753885
reactant: 019896
fast: false
product: 019908
modifier: 019944
reversible: false

298817
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: EP300

298822
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CREBBP

019896
type: SpeciesReference
stoichiometry: 1.0
species: 298877

019908
type: SpeciesReference
stoichiometry: 1.0
species: 298879

298857
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: PCAF

300781
type: Reaction
product: 029467
reactant: 029455
notes: Notes by CellDesigner PMID: 15210709 reaction: direct
fast: false
reversible: false

029467
type: SpeciesReference
stoichiometry: 1.0
species: 299507

029455
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301103
type: Reaction
product: 032270
reactant: 032258
notes: PMID: 15897325
fast: false
reversible: false

032270
type: SpeciesReference
stoichiometry: 1.0
species: 299713

299713
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SNRPE

032258
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299202
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: a852_degraded

300947
type: Reaction
product: 030781
reactant: 030769
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false

030781
type: SpeciesReference
stoichiometry: 1.0
species: 299626

299626
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: DRF1

030769
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300352
type: Reaction
product: 025863
reactant: 025851
notes: PMID: 14684737
fast: false
reversible: false

025863
type: SpeciesReference
stoichiometry: 1.0
species: 299441

299441
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BBC3

025851
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299630
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CSTF1

298980
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*/E2F1/DP1*/SWI/SNF/_br_HDAC1/SUV39H1/HP1gamma*

300907
type: Reaction
product: 030437
reactant: 030424
notes: Notes by CellDesigner PMID: 15510213 PMID: 16135806 reaction: direct
fast: false
reversible: false

030437
type: SpeciesReference
stoichiometry: 1.0
species: 299427

030424
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300543
type: Reaction
product: 027343
reactant: 027331
notes: PMID: 15510213
fast: false
reversible: false

027343
type: SpeciesReference
stoichiometry: 1.0
species: 299378

027331
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300499
type: Reaction
product: 026959
reactant: 026947
notes: PMID: 15464731
fast: false
reversible: false

026959
type: SpeciesReference
stoichiometry: 1.0
species: 299406

299406
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ISYNA1

026947
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300166
type: Reaction
modifier: 023654
product: 023642
reactant: 023630
notes: CDK activity stimulated by its CAK-complex phosphorylation. PMID: 12459251 PMID: 12814430 (ref REACTOME) PMID: 7629134
fast: false
reversible: false

023642
type: SpeciesReference
stoichiometry: 1.0
species: 298960

023630
type: SpeciesReference
stoichiometry: 1.0
species: 299224

299224
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*/CDK2

300954
type: Reaction
product: 030829
reactant: 030817
notes: Notes by CellDesigner PMID: 14633988 reaction: direct
fast: false
reversible: false

030829
type: SpeciesReference
stoichiometry: 1.0
species: 299346

030817
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300406
type: Reaction
product: 026347
reactant: 026335
fast: false
reversible: false

026347
type: SpeciesReference
stoichiometry: 1.0
species: 299420

299420
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: carboxylesterase*

026335
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301325
type: Reaction
modifier: 034371
product: 034359
reactant: 034347
notes: PMID: 15798220
fast: false
reversible: false

298958
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin A2*/CDK2

034359
type: SpeciesReference
stoichiometry: 1.0
species: 299823

299823
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p21Cip*

034347
type: SpeciesReference
stoichiometry: 1.0
species: 299825

300620
type: Reaction
product: 028063
reactant: 028051
notes: PMID: 15574595
fast: false
reversible: false

028063
type: SpeciesReference
stoichiometry: 1.0
species: 299556

299556
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDC6

028051
type: SpeciesReference
stoichiometry: 1.0
species: 299313

301318
type: Reaction
product: 034286
reactant: 034274
notes: PMID: 15574595
fast: false
reversible: false

034286
type: SpeciesReference
stoichiometry: 1.0
species: 299667

034274
type: SpeciesReference
stoichiometry: 1.0
species: 299313

301110
type: Reaction
product: 032342
reactant: 032330
notes: PMID: 16325355
fast: false
reversible: false

032342
type: SpeciesReference
stoichiometry: 1.0
species: 299701

299701
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCM8

032330
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300171
type: Reaction
modifier: 023726
product: 023714
reactant: 023702
notes: Phosphorylation of p27 by cyclin E/CDK2 at Thr-187 results in targeting p27 for its degradation by proteolysis PMID: 10385618
fast: false
reversible: false

023714
type: SpeciesReference
stoichiometry: 1.0
species: 299219

299219
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p27Kip1*

023702
type: SpeciesReference
stoichiometry: 1.0
species: 299088

298976
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: HP1gamma*

299270
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin A2*/CDK2/CDKN1A

300765
type: Reaction
product: 029323
reactant: 029311
notes: Notes by CellDesigner CCND3 induced by E2F3a PMID: 12611887
fast: false
reversible: false

029323
type: SpeciesReference
stoichiometry: 1.0
species: 299430

299430
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CCND3

029311
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300758
type: Reaction
product: 029251
reactant: 029239
notes: PMID: 15510213 PMID: 10733529
fast: false
reversible: false

029251
type: SpeciesReference
stoichiometry: 1.0
species: 299432

299432
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: cyclin A2*

029239
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300970
type: Reaction
product: 030973
reactant: 030961
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false

030973
type: SpeciesReference
stoichiometry: 1.0
species: 299623

299623
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: FBXO5

030961
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300595
type: Reaction
product: 027823
reactant: 027811
notes: Notes by CellDesigner PMID: 15271987 reaction: direct
fast: false
reversible: false

027823
type: SpeciesReference
stoichiometry: 1.0
species: 299516

299516
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BIRC5

027811
type: SpeciesReference
stoichiometry: 1.0
species: 299309

300656
type: Reaction
product: 028327
reactant: 028315
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

028327
type: SpeciesReference
stoichiometry: 1.0
species: 299378

028315
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300649
type: Reaction
product: 028255
reactant: 028243
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

028255
type: SpeciesReference
stoichiometry: 1.0
species: 299394

028243
type: SpeciesReference
stoichiometry: 1.0
species: 299313

301148
type: Reaction
product: 032702
reactant: 032690
notes: PMID: 16325355
fast: false
reversible: false

032702
type: SpeciesReference
stoichiometry: 1.0
species: 299701

032690
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300227
type: Reaction
modifier: 024434
product: 024422
reactant: 024410
notes: CDK activity stimulated by its CAK-complex phosphorylation. PMID: 12459251 (ref REACTOME) PMID: 16782892
fast: false
reversible: false

024422
type: SpeciesReference
stoichiometry: 1.0
species: 298962

024410
type: SpeciesReference
stoichiometry: 1.0
species: 299093

299093
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK6/CDKN1B

301090
type: Reaction
product: 032150
reactant: 032138
fast: false
reversible: false

032150
type: SpeciesReference
stoichiometry: 1.0
species: 299661

032138
type: SpeciesReference
stoichiometry: 1.0
species: 298863

300397
type: Reaction
product: 026272
reactant: 026260
notes: PMID: 10030670
fast: false
reversible: false

026272
type: SpeciesReference
stoichiometry: 1.0
species: 299425

299425
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: p21Cip*

026260
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299453
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ACTG1

300999
type: Reaction
product: 031261
reactant: 031249
notes: Notes by CellDesigner PMID: 15195143 reaction: direct
fast: false
reversible: false

031261
type: SpeciesReference
stoichiometry: 1.0
species: 299391

299391
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCM10

031249
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300020
type: Reaction
product: 022035
reactant: 022023
reactant: 022011
notes: (ref REACTOME) PMID: 9106657
fast: false
reversible: false

022035
type: SpeciesReference
stoichiometry: 1.0
species: 299119

299119
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK6/cyclin D1*

022023
type: SpeciesReference
stoichiometry: 1.0
species: 299075

299075
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: cyclin D1*

022011
type: SpeciesReference
stoichiometry: 1.0
species: 299044

300672
type: Reaction
product: 028471
reactant: 028459
notes: Notes by CellDesigner PMID: 11559537
fast: false
reversible: false

028471
type: SpeciesReference
stoichiometry: 1.0
species: 299574

299574
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BCL2

028459
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300118
type: Reaction
product: 023102
reactant: 023090
notes: PMID: 10373560 (from REACTOME) PMID: 11063929
fast: false
reversible: false

023102
type: SpeciesReference
stoichiometry: 1.0
species: 299157

023090
type: SpeciesReference
stoichiometry: 1.0
species: 299175

299148
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC2

300288
type: Reaction
product: 025191
reactant: 025179
notes: Cell cycle inhibition by sequestration of DP1 in the nucleolus. PMID: 16135794 PMID: 12446760
fast: false
reversible: false

025191
type: SpeciesReference
stoichiometry: 1.0
species: 298897

298897
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298791
name: p14ARF*/DP1*

298791
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: nucleole

025179
type: SpeciesReference
stoichiometry: 1.0
species: 299295

299954
type: Reaction
product: 021157
reactant: 021145
reactant: 021133
notes: The recruitment of SUV39H1 allows that of HP1 PMID: 11484059 PMID: 15126619 PMID: 11420729 PMID: 15838516
fast: false
reversible: false

021157
type: SpeciesReference
stoichiometry: 1.0
species: 298980

021145
type: SpeciesReference
stoichiometry: 1.0
species: 298989

298989
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: SWI/SNF/HDAC1/SUV39H1/_br_pRB*/E2F1/DP1*

021133
type: SpeciesReference
stoichiometry: 1.0
species: 298976

300211
type: Reaction
product: 024242
reactant: 024230
reactant: 024218
fast: false
reversible: false

024242
type: SpeciesReference
stoichiometry: 1.0
species: 299228

299228
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: APC/FZR1

024230
type: SpeciesReference
stoichiometry: 1.0
species: 299237

024218
type: SpeciesReference
stoichiometry: 1.0
species: 299213

299213
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDH1

299696
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: FOXO3a

300803
type: Reaction
product: 029683
reactant: 029671
notes: Notes by CellDesigner PMID: 14990995
fast: false
reversible: false

029683
type: SpeciesReference
stoichiometry: 1.0
species: 299410

299410
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: GMNN

029671
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301083
type: Reaction
product: 032078
reactant: 032066
notes: Notes by CellDesigner PMID: 16179649
fast: false
reversible: false

032078
type: SpeciesReference
stoichiometry: 1.0
species: 299556

032066
type: SpeciesReference
stoichiometry: 1.0
species: 299311

299311
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F8

299567
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SIP*

300293
type: Reaction
product: 025239
reactant: 025227
notes: PMID: 9819415
fast: false
reversible: false

025239
type: SpeciesReference
stoichiometry: 1.0
species: 299289

299289
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: a895_degraded

025227
type: SpeciesReference
stoichiometry: 1.0
species: 299322

299322
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p53*

300349
type: Reaction
product: 025839
reactant: 025827
notes: PMID: 15572025 PMID: 15766563
fast: false
reversible: false

025839
type: SpeciesReference
stoichiometry: 1.0
species: 299444

299444
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: AXIN2

025827
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300887
type: Reaction
product: 030235
reactant: 030223
notes: Notes by CellDesigner PMID: 15271987 reaction: direct
fast: false
reversible: false

030235
type: SpeciesReference
stoichiometry: 1.0
species: 299516

030223
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299492
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: FGFR2

300810
type: Reaction
product: 029755
reactant: 029743
notes: Notes by CellDesigner PMID: 14990995 reaction: indirect intermediate: MYC
fast: false
reversible: false

029755
type: SpeciesReference
stoichiometry: 1.0
species: 299683

299683
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCM7

029743
type: SpeciesReference
stoichiometry: 1.0
species: 299838

299070
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: GSK3B

301302
type: Reaction
product: 034142
reactant: 034130
notes: PMID: 15014447
fast: false
reversible: false

034142
type: SpeciesReference
stoichiometry: 1.0
species: 299527

034130
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299797
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CHEK1

299287
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p53*

299369
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RBBP8

300097
type: Reaction
modifier: 022874
product: 022862
reactant: 022850
notes: dephosphorylation of CDC2 induce its activation PMID: 10373560 PMID: 8348613 PMID: 12814430
fast: false
reversible: false

022862
type: SpeciesReference
stoichiometry: 1.0
species: 299166

299166
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC2/cyclin B1*

022850
type: SpeciesReference
stoichiometry: 1.0
species: 299157

298912
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p107*

298992
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin C*/CDK3

301277
type: Reaction
product: 033902
reactant: 033890
notes: PMID: 16580749
fast: false
reversible: false

033902
type: SpeciesReference
stoichiometry: 1.0
species: 299786

033890
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300990
type: Reaction
product: 031165
reactant: 031153
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

031165
type: SpeciesReference
stoichiometry: 1.0
species: 299394

031153
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300701
type: Reaction
product: 028735
reactant: 028723
notes: Notes by CellDesigner PMID: 11564866 reaction: direct
fast: false
reversible: false

028735
type: SpeciesReference
stoichiometry: 1.0
species: 299598

028723
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300871
type: Reaction
product: 030091
reactant: 030079
notes: Notes by CellDesigner PMID: 10733529 PMID: 15014447 reaction: direct
fast: false
reversible: false

030091
type: SpeciesReference
stoichiometry: 1.0
species: 299681

030079
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300967
type: Reaction
product: 030949
reactant: 030937
notes: Notes by CellDesigner PMID: 14532106 reaction: directPMID: 15574337
fast: false
reversible: false

030949
type: SpeciesReference
stoichiometry: 1.0
species: 299412

030937
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299215
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: FZR1

299917
type: Reaction
product: 020653
product: 020641
product: 020629
reactant: 020617
fast: false
reversible: false

020653
type: SpeciesReference
stoichiometry: 1.0
species: 298923

020641
type: SpeciesReference
stoichiometry: 1.0
species: 298926

298926
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: DP2*

020629
type: SpeciesReference
stoichiometry: 1.0
species: 298912

020617
type: SpeciesReference
stoichiometry: 1.0
species: 298933

298933
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p107*/E2F4/DP2*

299654
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CLSPN

300247
type: Reaction
product: 024650
reactant: 024638
reactant: 024626
notes: 12836612
fast: false
reversible: false

024650
type: SpeciesReference
stoichiometry: 1.0
species: 299268

299268
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*/CDK2/CDKN1A

024638
type: SpeciesReference
stoichiometry: 1.0
species: 299825

024626
type: SpeciesReference
stoichiometry: 1.0
species: 298960

300340
type: Reaction
product: 025767
reactant: 025755
notes: PMID: 12527885
fast: false
reversible: false

025767
type: SpeciesReference
stoichiometry: 1.0
species: 299658

299658
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ATM

025755
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300333
type: Reaction
product: 025695
reactant: 025683
notes: PMID: 15897325
fast: false
reversible: false

025695
type: SpeciesReference
stoichiometry: 1.0
species: 299451

299451
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ACTN4

025683
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299439
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BCL2L11

300983
type: Reaction
product: 031093
reactant: 031081
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false

031093
type: SpeciesReference
stoichiometry: 1.0
species: 299612

299612
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: KNTC2

031081
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300974
type: Reaction
product: 031021
reactant: 031009
notes: Notes by CellDesigner PMID: 14990995 reaction: direct
fast: false
reversible: false

031021
type: SpeciesReference
stoichiometry: 1.0
species: 299410

031009
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299364
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDC20

300058
type: Reaction
product: 022439
reactant: 022426
reactant: 022413
notes: PMID: 10385618 PMID: 10498883
fast: false
reversible: false

022439
type: SpeciesReference
stoichiometry: 1.0
species: 299110

299110
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC37/HSP90/CDK4

022426
type: SpeciesReference
stoichiometry: 1.0
species: 299113

299113
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK4/CDC37

022413
type: SpeciesReference
stoichiometry: 1.0
species: 299079

299079
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: HSP90

300179
type: Reaction
modifier: 023834
product: 023822
reactant: 023810
notes: Cyclin E phosphorylation by CDK2 at Thr-380. PMID: 8861947 Autophosphorylation of the complex cyclinE/CDK2 at Thr-380 and Thr-62. Phosphorylation at Thr-380 also by GSK-3B. Two other sites of regulation: Ser-372 et Ser-384 PMID: 16131838
fast: false
reversible: false

023822
type: SpeciesReference
stoichiometry: 1.0
species: 299226

299226
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*/CDK2

023810
type: SpeciesReference
stoichiometry: 1.0
species: 298960

300102
type: Reaction
product: 022934
reactant: 022922
reactant: 022910
notes: Cytoplasmic binding PMID: 9001210 (ref REACTOME) PMID: 1717476
fast: false
reversible: false

022934
type: SpeciesReference
stoichiometry: 1.0
species: 299173

022922
type: SpeciesReference
stoichiometry: 1.0
species: 299126

299126
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: cyclin B1*

022910
type: SpeciesReference
stoichiometry: 1.0
species: 299132

299132
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC2

299235
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK2/cyclin E1*/CDKN1B

299548
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCM5

299853
type: Reaction
product: 019884
reactant: 019872
reactant: 019860
fast: false
reversible: false

019884
type: SpeciesReference
stoichiometry: 1.0
species: 298877

019872
type: SpeciesReference
stoichiometry: 1.0
species: 298835

298835
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: DP1*

019860
type: SpeciesReference
stoichiometry: 1.0
species: 298863

301031
type: Reaction
product: 031573
reactant: 031561
notes: Notes by CellDesigner PMID: 15510213 reaction: direct
fast: false
reversible: false

031573
type: SpeciesReference
stoichiometry: 1.0
species: 299378

031561
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299703
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: miR-17-92

299783
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDCA4

299049
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: SERTAD1

299990
type: Reaction
product: 021637
reactant: 021625
reactant: 021613
notes: PMID: 12004135 PMID: 15126619 PMID: 15536069
fast: false
reversible: false

021637
type: SpeciesReference
stoichiometry: 1.0
species: 299031

021625
type: SpeciesReference
stoichiometry: 1.0
species: 298976

021613
type: SpeciesReference
stoichiometry: 1.0
species: 299033

299033
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6/MAX/DP1*/MGA/BAT8/EHMT1

299503
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CNAP1

300900
type: Reaction
product: 030360
reactant: 030348
notes: PMID: 15510213 PMID: 10766737
fast: false
reversible: false

030360
type: SpeciesReference
stoichiometry: 1.0
species: 299432

030348
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299583
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ECE1B

300317
type: Reaction
reactant: 025491
modifier: 025527
notes: Protein stabilized by phosphorylation. PMID: 15838517 PMID: 15140942
reversible: false
product: 025515
fast: false
modifier: 025539
product: 025503

025491
type: SpeciesReference
stoichiometry: 1.0
species: 298881

025515
type: SpeciesReference
stoichiometry: 1.0
species: 298888

298888
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/DP1*

299335
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CHEK2

025503
type: SpeciesReference
stoichiometry: 1.0
species: 298857

300487
type: Reaction
product: 026911
reactant: 026899
notes: PMID: 15985428
fast: false
reversible: false

026911
type: SpeciesReference
stoichiometry: 1.0
species: 299687

026899
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300823
type: Reaction
product: 029851
reactant: 029839
notes: Notes by CellDesigner PMID: 12438307 reaction: direct
fast: false
reversible: false

029851
type: SpeciesReference
stoichiometry: 1.0
species: 299689

029839
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301322
type: Reaction
product: 034334
reactant: 034322
notes: PMID: 15574595
fast: false
reversible: false

034334
type: SpeciesReference
stoichiometry: 1.0
species: 299527

034322
type: SpeciesReference
stoichiometry: 1.0
species: 299313

299084
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: cyclin D1*

298919
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: DP2*

301168
type: Reaction
product: 032894
reactant: 032882
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

032894
type: SpeciesReference
stoichiometry: 1.0
species: 299730

299730
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SPAG7

032882
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300753
type: Reaction
product: 029203
reactant: 029191
notes: Notes by CellDesigner PMID: 15271987 reaction: direct
fast: false
reversible: false

029203
type: SpeciesReference
stoichiometry: 1.0
species: 299516

029191
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300385
type: Reaction
product: 026175
reactant: 026163
notes: PMID: 8618861
fast: false
reversible: false

026175
type: SpeciesReference
stoichiometry: 1.0
species: 299671

026163
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300378
type: Reaction
product: 026103
reactant: 026091
notes: PMID: 15510213
fast: false
reversible: false

026103
type: SpeciesReference
stoichiometry: 1.0
species: 299432

026091
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299477
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F4 cofactors

301252
type: Reaction
product: 033662
reactant: 033650
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

033662
type: SpeciesReference
stoichiometry: 1.0
species: 299778

033650
type: SpeciesReference
stoichiometry: 1.0
species: 298923

301175
type: Reaction
product: 032966
reactant: 032954
notes: PMID: 11564866
fast: false
reversible: false

032966
type: SpeciesReference
stoichiometry: 1.0
species: 299738

299738
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SUZ12

032954
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299396
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCL1

301059
type: Reaction
product: 031837
reactant: 031825
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

031837
type: SpeciesReference
stoichiometry: 1.0
species: 299369

031825
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300439
type: Reaction
product: 026647
reactant: 026635
notes: PMID: 16107498
fast: false
reversible: false

026647
type: SpeciesReference
stoichiometry: 1.0
species: 299343

299343
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: E2F6

026635
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300138
type: Reaction
modifier: 023306
product: 023294
reactant: 023282
notes: Phosphorylation only when CDC2 is bound to the cyclin D. PMID: 10373560 PMID: 9001210 PMID: 12814430
fast: false
reversible: false

299135
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: PKMYT1

023294
type: SpeciesReference
stoichiometry: 1.0
species: 299177

299177
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC2/cyclin B1*

023282
type: SpeciesReference
stoichiometry: 1.0
species: 299180

300017
type: Reaction
modifier: 021999
product: 021987
reactant: 021975
reactant: 021962
notes: (ref REACTOME) PMID: 8078588 PMID: 8741839 PMID: 8001816 PMID: 8259215
fast: false
reversible: false

021987
type: SpeciesReference
stoichiometry: 1.0
species: 299063

299063
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK4/p16INK4a*

021975
type: SpeciesReference
stoichiometry: 1.0
species: 299051

299051
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p16INK4a*

021962
type: SpeciesReference
stoichiometry: 1.0
species: 299054

299054
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK4

301250
type: Reaction
product: 033638
reactant: 033626
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

033638
type: SpeciesReference
stoichiometry: 1.0
species: 299778

033626
type: SpeciesReference
stoichiometry: 1.0
species: 299843

299898
type: Reaction
product: 020424
reactant: 020412
notes: Degradation depends upon ubiquitination. E3: F-box protein p45Skp2 PMID: 16213134
fast: false
reversible: false

020424
type: SpeciesReference
stoichiometry: 1.0
species: 298861

020412
type: SpeciesReference
stoichiometry: 1.0
species: 298872

298872
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1

300644
type: Reaction
product: 028207
reactant: 028195
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

028207
type: SpeciesReference
stoichiometry: 1.0
species: 299494

299494
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: EXOSC8

028195
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300224
type: Reaction
product: 024398
reactant: 024386
reactant: 024374
reactant: 024362
fast: false
reversible: false

024398
type: SpeciesReference
stoichiometry: 1.0
species: 299255

299255
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK7/cyclin H*/MNAT1

024386
type: SpeciesReference
stoichiometry: 1.0
species: 299248

024374
type: SpeciesReference
stoichiometry: 1.0
species: 299252

299252
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK7

024362
type: SpeciesReference
stoichiometry: 1.0
species: 299250

299250
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin H*

301143
type: Reaction
product: 032654
reactant: 032642
notes: PMID: 17482685
fast: false
reversible: false

032654
type: SpeciesReference
stoichiometry: 1.0
species: 299696

032642
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301066
type: Reaction
product: 031909
reactant: 031897
notes: PMID: 16135806
fast: false
reversible: false

031909
type: SpeciesReference
stoichiometry: 1.0
species: 299608

031897
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300369
type: Reaction
product: 026031
reactant: 026019
notes: PMID: 12389032
fast: false
reversible: false

026031
type: SpeciesReference
stoichiometry: 1.0
species: 299561

299561
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CASP8

026019
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300576
type: Reaction
product: 027655
reactant: 027643
notes: PMID: 11313881
fast: false
reversible: false

027655
type: SpeciesReference
stoichiometry: 1.0
species: 299589

299589
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RPA2

027643
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300868
type: Reaction
product: 030067
reactant: 030055
notes: Notes by CellDesigner PMID: 15014447 reaction: direct
fast: false
reversible: false

030067
type: SpeciesReference
stoichiometry: 1.0
species: 299647

299647
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RRM1

030055
type: SpeciesReference
stoichiometry: 1.0
species: 299838

299466
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: HRK

300660
type: Reaction
product: 028375
reactant: 028363
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

028375
type: SpeciesReference
stoichiometry: 1.0
species: 299371

028363
type: SpeciesReference
stoichiometry: 1.0
species: 299313

301358
type: Reaction
product: 034723
reactant: 034710
fast: false
reversible: false

034723
type: SpeciesReference
stoichiometry: 1.0
species: 299311

034710
type: SpeciesReference
stoichiometry: 1.0
species: 299581

299581
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F8 cofactors

300637
type: Reaction
product: 028159
reactant: 028147
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

028159
type: SpeciesReference
stoichiometry: 1.0
species: 299501

299501
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: DDX11

028147
type: SpeciesReference
stoichiometry: 1.0
species: 299313

299821
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p21Cip*

299065
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK6/p16INK4a*

300891
type: Reaction
product: 030285
reactant: 030273
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false

030285
type: SpeciesReference
stoichiometry: 1.0
species: 299634

299634
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BTRC

030273
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300884
type: Reaction
product: 030211
reactant: 030199
notes: Notes by CellDesigner PMID: 11559537
fast: false
reversible: false

030211
type: SpeciesReference
stoichiometry: 1.0
species: 299574

030199
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300607
type: Reaction
product: 027943
reactant: 027931
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

027943
type: SpeciesReference
stoichiometry: 1.0
species: 299512

299512
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BRCA1

027931
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300987
type: Reaction
product: 031141
reactant: 031129
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false

031141
type: SpeciesReference
stoichiometry: 1.0
species: 299550

031129
type: SpeciesReference
stoichiometry: 1.0
species: 298923

298847
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: ATM

299576
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F5 cofactors

300945
type: Reaction
product: 030757
reactant: 030745
notes: Notes by CellDesigner PMID: 16158053 reaction: direct
fast: false
reversible: false

030757
type: SpeciesReference
stoichiometry: 1.0
species: 299470

299470
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: DIRAS3

030745
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299987
type: Reaction
product: 021601
reactant: 021589
reactant: 021577
reactant: 021565
notes: PMID: 12004135 PMID: 15126619
fast: false
reversible: false

021601
type: SpeciesReference
stoichiometry: 1.0
species: 299033

021589
type: SpeciesReference
stoichiometry: 1.0
species: 299002

299002
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: EHMT1

021577
type: SpeciesReference
stoichiometry: 1.0
species: 299011

299011
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: BAT8

021565
type: SpeciesReference
stoichiometry: 1.0
species: 299035

299035
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6/DP1*/MAX/MGA

299905
type: Reaction
product: 020521
reactant: 020509
reactant: 020496
notes: PMID: 15231644
fast: false
reversible: false

020521
type: SpeciesReference
stoichiometry: 1.0
species: 298949

020509
type: SpeciesReference
stoichiometry: 1.0
species: 298910

020496
type: SpeciesReference
stoichiometry: 1.0
species: 298946

298946
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F4/DP2*

300689
type: Reaction
product: 028639
reactant: 028627
notes: Notes by CellDesigner PMID: 10766737 reaction: direct
fast: false
reversible: false

028639
type: SpeciesReference
stoichiometry: 1.0
species: 299556

028627
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300605
type: Reaction
product: 027919
reactant: 027907
notes: Notes by CellDesigner PMID: 12150994 reaction: direct
fast: false
reversible: false

027919
type: SpeciesReference
stoichiometry: 1.0
species: 299483

027907
type: SpeciesReference
stoichiometry: 1.0
species: 299309

298956
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*/E2F1/DP1*/SWI/SNF/HDAC1

301265
type: Reaction
product: 033782
reactant: 033770
notes: PMID: 16984923
fast: false
reversible: false

033782
type: SpeciesReference
stoichiometry: 1.0
species: 299783

033770
type: SpeciesReference
stoichiometry: 1.0
species: 299843

301193
type: Reaction
product: 033134
reactant: 033122
notes: Notes by CellDesigner PMID: 15731768
fast: false
reversible: false

033134
type: SpeciesReference
stoichiometry: 1.0
species: 299748

299748
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TP53BP2

033122
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301188
type: Reaction
product: 033086
reactant: 033074
notes: Notes by CellDesigner PMID: 15731768
fast: false
reversible: false

033086
type: SpeciesReference
stoichiometry: 1.0
species: 299748

033074
type: SpeciesReference
stoichiometry: 1.0
species: 299843

301012
type: Reaction
product: 031381
reactant: 031369
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false

031381
type: SpeciesReference
stoichiometry: 1.0
species: 299534

031369
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299810
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TERT

300409
type: Reaction
product: 026372
reactant: 026360
notes: PMID: 15706352 PMID: 12909625
fast: false
reversible: false

026372
type: SpeciesReference
stoichiometry: 1.0
species: 299472

026360
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301270
type: Reaction
product: 033830
reactant: 033818
notes: PMID: 16984923
fast: false
reversible: false

033830
type: SpeciesReference
stoichiometry: 1.0
species: 299783

033818
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300244
type: Reaction
product: 024614
reactant: 024602
reactant: 024590
notes: 12836612
fast: false
reversible: false

024614
type: SpeciesReference
stoichiometry: 1.0
species: 299270

024602
type: SpeciesReference
stoichiometry: 1.0
species: 299825

024590
type: SpeciesReference
stoichiometry: 1.0
species: 298958

299656
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PBK

299191
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin A2*

300305
type: Reaction
product: 025359
reactant: 025347
fast: false
reversible: false

025359
type: SpeciesReference
stoichiometry: 1.0
species: 299005

299005
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F8

025347
type: SpeciesReference
stoichiometry: 1.0
species: 299311

300174
type: Reaction
product: 023762
reactant: 023750
reactant: 023738
notes: Complex cyclinE-CDK2 inhibited by its interaction with CKI. PMID: 10385618
fast: false
reversible: false

023762
type: SpeciesReference
stoichiometry: 1.0
species: 299235

023750
type: SpeciesReference
stoichiometry: 1.0
species: 299088

023738
type: SpeciesReference
stoichiometry: 1.0
species: 299224

300053
type: Reaction
product: 022400
reactant: 022387
reactant: 022373
notes: PMID: 10385618 PMID: 10498883
fast: false
reversible: false

022400
type: SpeciesReference
stoichiometry: 1.0
species: 299113

022387
type: SpeciesReference
stoichiometry: 1.0
species: 299082

299082
type: Species
notes: Targets HSP90 to CDK4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC37

022373
type: SpeciesReference
stoichiometry: 1.0
species: 299056

301342
type: Reaction
product: 034569
reactant: 034557
fast: false
reversible: false

034569
type: SpeciesReference
stoichiometry: 1.0
species: 299840

034557
type: SpeciesReference
stoichiometry: 1.0
species: 299337

301335
type: Reaction
product: 034482
reactant: 034470
reactant: 034458
notes: p130 binds to and inhibits cyclinE-CDK2, independantly of its phosphorylation state. PMID: 15456871 PMID: 12006580 PMID: 11237530
fast: false
reversible: false

034482
type: SpeciesReference
stoichiometry: 1.0
species: 299836

299836
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*/CDK2/p107

034470
type: SpeciesReference
stoichiometry: 1.0
species: 298910

034458
type: SpeciesReference
stoichiometry: 1.0
species: 298960

300680
type: Reaction
product: 028543
reactant: 028531
notes: PMID: 15510213
fast: false
reversible: false

028543
type: SpeciesReference
stoichiometry: 1.0
species: 299559

028531
type: SpeciesReference
stoichiometry: 1.0
species: 299843

299971
type: Reaction
product: 021397
reactant: 021385
reactant: 021373
fast: false
reversible: false

021397
type: SpeciesReference
stoichiometry: 1.0
species: 299040

021385
type: SpeciesReference
stoichiometry: 1.0
species: 298919

021373
type: SpeciesReference
stoichiometry: 1.0
species: 298994

298994
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F6

299320
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: WEE1

299850
type: Reaction
product: 019848
reactant: 019836
reactant: 019823
fast: false
reversible: false

019848
type: SpeciesReference
stoichiometry: 1.0
species: 298881

019836
type: SpeciesReference
stoichiometry: 1.0
species: 298857

019823
type: SpeciesReference
stoichiometry: 1.0
species: 298879

300729
type: Reaction
product: 028999
reactant: 028987
notes: Notes by CellDesigner PMID: 11564866 reaction: direct
fast: false
reversible: false

028999
type: SpeciesReference
stoichiometry: 1.0
species: 299483

028987
type: SpeciesReference
stoichiometry: 1.0
species: 299843

299486
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: GAB2

301233
type: Reaction
product: 033494
reactant: 033482
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

033494
type: SpeciesReference
stoichiometry: 1.0
species: 299772

299772
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ZNF451

033482
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300734
type: Reaction
product: 029047
reactant: 029035
notes: Notes by CellDesigner PMID: 12665581
fast: false
reversible: false

029047
type: SpeciesReference
stoichiometry: 1.0
species: 299384

029035
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300482
type: Reaction
product: 026863
reactant: 026851
notes: PMID: 15574337
fast: false
reversible: false

026863
type: SpeciesReference
stoichiometry: 1.0
species: 299486

026851
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299086
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: a838_degraded

300503
type: Reaction
product: 026983
reactant: 026971
notes: PMID: 15706352
fast: false
reversible: false

026983
type: SpeciesReference
stoichiometry: 1.0
species: 299403

299403
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: JMY

026971
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300459
type: Reaction
product: 026791
reactant: 026779
notes: PMID: 12944911
fast: false
reversible: false

026791
type: SpeciesReference
stoichiometry: 1.0
species: 299492

026779
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299962
type: Reaction
modifier: 021313
modifier: 021289
product: 021265
notes: Phosphorylation of pRB PMID: 9315635 dissociation of HDAC1 (during the G1 to S transition) PMID: 10778858 PMID: 11520855 PMID: 7736585, PMID: 9425340 weinberg CycD phosphorylates RB (ref REACTOME) PMID: 9190208
modifier: 021277
product: 021253
fast: false
reversible: false
modifier: 021301
reactant: 021241

021265
type: SpeciesReference
stoichiometry: 1.0
species: 298987

021253
type: SpeciesReference
stoichiometry: 1.0
species: 298807

021241
type: SpeciesReference
stoichiometry: 1.0
species: 298985

298985
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*/E2F1/DP1*/SWI/SNF/HDAC1

300806
type: Reaction
product: 029707
reactant: 029695
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

029707
type: SpeciesReference
stoichiometry: 1.0
species: 299362

299362
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: KPNA2

029695
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300750
type: Reaction
product: 029179
reactant: 029167
notes: Notes by CellDesigner PMID: 12527885
fast: false
reversible: false

029179
type: SpeciesReference
stoichiometry: 1.0
species: 299658

029167
type: SpeciesReference
stoichiometry: 1.0
species: 299838

298874
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*/E2F1/DP1*

299307
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298791
name: E2F1/p14ARF*

300203
type: Reaction
product: 024134
reactant: 024122
reactant: 024110
fast: false
reversible: false

024134
type: SpeciesReference
stoichiometry: 1.0
species: 298958

024122
type: SpeciesReference
stoichiometry: 1.0
species: 299191

024110
type: SpeciesReference
stoichiometry: 1.0
species: 299193

301079
type: Reaction
product: 032030
reactant: 032018
notes: PMID: 16179649
fast: false
reversible: false

032030
type: SpeciesReference
stoichiometry: 1.0
species: 299559

032018
type: SpeciesReference
stoichiometry: 1.0
species: 299311

299479
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: E2F8

300727
type: Reaction
product: 028975
reactant: 028963
notes: Notes by CellDesigner PMID: 10766737 reaction: direct
fast: false
reversible: false

028975
type: SpeciesReference
stoichiometry: 1.0
species: 299462

028963
type: SpeciesReference
stoichiometry: 1.0
species: 299843

301163
type: Reaction
product: 032846
reactant: 032834
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

032846
type: SpeciesReference
stoichiometry: 1.0
species: 299730

032834
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300564
type: Reaction
product: 027535
reactant: 027523
notes: PMID: 12909625
fast: false
reversible: false

027535
type: SpeciesReference
stoichiometry: 1.0
species: 299459

299459
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RAD51AP1

027523
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301217
type: Reaction
product: 033350
reactant: 033338
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

033350
type: SpeciesReference
stoichiometry: 1.0
species: 299765

299765
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TYMS

033338
type: SpeciesReference
stoichiometry: 1.0
species: 298923

301161
type: Reaction
product: 032822
reactant: 032810
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false

032822
type: SpeciesReference
stoichiometry: 1.0
species: 299728

299728
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SOAT2

032810
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300555
type: Reaction
product: 027463
reactant: 027451
notes: PMID: 15711575 PMID: 12110166
fast: false
reversible: false

027463
type: SpeciesReference
stoichiometry: 1.0
species: 299596

027451
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300434
type: Reaction
product: 026599
reactant: 026587
notes: PMID: 10766737 PMID: 14576826
fast: false
reversible: false

026599
type: SpeciesReference
stoichiometry: 1.0
species: 299339

299339
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: E2F1

026587
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301047
type: Reaction
product: 031741
reactant: 031729
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false

031741
type: SpeciesReference
stoichiometry: 1.0
species: 299523

031729
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300005
type: Reaction
modifier: 021841
product: 021829
reactant: 021817
reactant: 021805
notes: sequestration of CDK4 to prevent its association with Cyclins D and RB phosphorylation. PMID: 11960696 (ref REACTOME) PMID: 8078588 PMID: 8741839 PMID: 8001816 PMID: 8259215
fast: false
reversible: false

021829
type: SpeciesReference
stoichiometry: 1.0
species: 299063

021817
type: SpeciesReference
stoichiometry: 1.0
species: 299051

021805
type: SpeciesReference
stoichiometry: 1.0
species: 299056

299743
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: THEM2

299930
type: Reaction
product: 020809
reactant: 020797
reactant: 020785
fast: false
reversible: false

020809
type: SpeciesReference
stoichiometry: 1.0
species: 298942

298942
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F4/DP2*

020797
type: SpeciesReference
stoichiometry: 1.0
species: 298921

298921
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F4

020785
type: SpeciesReference
stoichiometry: 1.0
species: 298919

301131
type: Reaction
product: 032534
reactant: 032522
notes: PMID: 17178835
fast: false
reversible: false

032534
type: SpeciesReference
stoichiometry: 1.0
species: 299705

299705
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: NRP1

032522
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301108
type: Reaction
product: 032318
reactant: 032306
notes: PMID: 17482685
fast: false
reversible: false

032318
type: SpeciesReference
stoichiometry: 1.0
species: 299692

299692
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: FOXO1

032306
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300366
type: Reaction
product: 026007
reactant: 025995
notes: PMID: 12389032
fast: false
reversible: false

026007
type: SpeciesReference
stoichiometry: 1.0
species: 299563

299563
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CASP7

025995
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301052
type: Reaction
product: 031789
reactant: 031777
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false

031789
type: SpeciesReference
stoichiometry: 1.0
species: 299520

299520
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RAD54L

031777
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300779
type: Reaction
product: 029443
reactant: 029431
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

029443
type: SpeciesReference
stoichiometry: 1.0
species: 299364

029431
type: SpeciesReference
stoichiometry: 1.0
species: 299838

299543
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MLH1

300357
type: Reaction
product: 025911
reactant: 025899
notes: PMID: 14684737
fast: false
reversible: false

025911
type: SpeciesReference
stoichiometry: 1.0
species: 299439

025899
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300571
type: Reaction
product: 027607
reactant: 027595
notes: PMID: 10766737
fast: false
reversible: false

027607
type: SpeciesReference
stoichiometry: 1.0
species: 299812

299812
type: Species
notes: also p107*
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RBL1

027595
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300450
type: Reaction
product: 026719
reactant: 026707
notes: PMID: 16275992 PMID: 12214268
fast: false
reversible: false

026719
type: SpeciesReference
stoichiometry: 1.0
species: 299496

299496
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: EIF2AK2

026707
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300066
type: Reaction
product: 022513
product: 022501
reactant: 022489
notes: PMID: 10385618 PMID: 10498883
fast: false
reversible: false

022513
type: SpeciesReference
stoichiometry: 1.0
species: 299115

299115
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC37/HSP90

022501
type: SpeciesReference
stoichiometry: 1.0
species: 299054

022489
type: SpeciesReference
stoichiometry: 1.0
species: 299110

300548
type: Reaction
product: 027391
reactant: 027379
notes: PMID: 14684737
fast: false
reversible: false

027391
type: SpeciesReference
stoichiometry: 1.0
species: 299375

299375
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PMAIP1

027379
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301009
type: Reaction
product: 031357
reactant: 031345
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false

031357
type: SpeciesReference
stoichiometry: 1.0
species: 299537

299537
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MSH2

031345
type: SpeciesReference
stoichiometry: 1.0
species: 298923

301283
type: Reaction
product: 033950
reactant: 033938
notes: PMID: 16741925
fast: false
reversible: false

033950
type: SpeciesReference
stoichiometry: 1.0
species: 299788

299788
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PURALPHA

033938
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299925
type: Reaction
product: 020749
reactant: 020737
reactant: 020725
reactant: 020713
notes: PMID: 15126619 PMID: 15838516 The recruitment of SWI/SNF seems to be necessary for the recrutement de HDAC1 PMID: 11420729 PMID: 15105433
fast: false
reversible: false

020749
type: SpeciesReference
stoichiometry: 1.0
species: 298956

020737
type: SpeciesReference
stoichiometry: 1.0
species: 298915

298915
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: SWI/SNF

020725
type: SpeciesReference
stoichiometry: 1.0
species: 298874

020713
type: SpeciesReference
stoichiometry: 1.0
species: 298807

299923
type: Reaction
product: 020701
reactant: 020689
fast: false
reversible: false

020701
type: SpeciesReference
stoichiometry: 1.0
species: 298919

020689
type: SpeciesReference
stoichiometry: 1.0
species: 298926

300625
type: Reaction
product: 028111
reactant: 028099
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

028111
type: SpeciesReference
stoichiometry: 1.0
species: 299472

028099
type: SpeciesReference
stoichiometry: 1.0
species: 299313

301124
type: Reaction
product: 032486
reactant: 032474
notes: PMID: 15590326
fast: false
reversible: false

032486
type: SpeciesReference
stoichiometry: 1.0
species: 299814

032474
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300795
type: Reaction
product: 029611
reactant: 029599
notes: Notes by CellDesigner PMID: 14532106 reaction: direct
fast: false
reversible: false

029611
type: SpeciesReference
stoichiometry: 1.0
species: 299416

299416
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: EED

029599
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300071
type: Reaction
product: 022585
product: 022573
reactant: 022561
fast: false
reversible: false

022585
type: SpeciesReference
stoichiometry: 1.0
species: 299044

022573
type: SpeciesReference
stoichiometry: 1.0
species: 299084

022561
type: SpeciesReference
stoichiometry: 1.0
species: 299106

299341
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: E2F3

301201
type: Reaction
product: 033206
reactant: 033194
notes: PMID: 12838312
fast: false
reversible: false

033206
type: SpeciesReference
stoichiometry: 1.0
species: 299754

033194
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299774
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: WDR36

301025
type: Reaction
product: 031525
reactant: 031513
notes: Notes by CellDesigner PMID: 12766778 reaction: direct
fast: false
reversible: false

031525
type: SpeciesReference
stoichiometry: 1.0
species: 299380

299380
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: p14ARF*

031513
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299531
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: NEK2

300187
type: Reaction
product: 023930
reactant: 023918
notes: Degradation via the ubiquitin/proteasome system. PMID: 8861947
fast: false
reversible: false

023930
type: SpeciesReference
stoichiometry: 1.0
species: 299202

023918
type: SpeciesReference
stoichiometry: 1.0
species: 299207

299207
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*

298983
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: SUV39H1/_br_HP1gamma*

300856
type: Reaction
product: 029947
reactant: 029935
notes: Notes by CellDesigner PMID: 12748276 PMID: 15574595 reaction: direct
fast: false
reversible: false

029947
type: SpeciesReference
stoichiometry: 1.0
species: 299650

029935
type: SpeciesReference
stoichiometry: 1.0
species: 299838

298790
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0

298859
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: TFIIH*

300940
type: Reaction
product: 030709
reactant: 030697
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

030709
type: SpeciesReference
stoichiometry: 1.0
species: 299501

030697
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300264
type: Reaction
modifier: 024902
product: 024890
reactant: 024878
notes: PMID: 15024084 Phosphorylation by ATR at Ser-317 et Ser-345 (ref REACTOME) PMID: 15190204 PMID: 10859163 PMID: 11090622 PMID: 11390642 PMID: 15279789 PMID: 12781359 PMID: 15272308 PMID: 12766152 PMID: 16431910 PMID: 10859164 PMID: 16360315
fast: false
reversible: false

024890
type: SpeciesReference
stoichiometry: 1.0
species: 299799

299799
type: Species
notes: ATR phosphorylate Ser-317 and Ser-345
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CHEK1

024878
type: SpeciesReference
stoichiometry: 1.0
species: 299797

299418
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: Cox IV*

300933
type: Reaction
product: 030637
reactant: 030625
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false

030637
type: SpeciesReference
stoichiometry: 1.0
species: 299654

030625
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300600
type: Reaction
product: 027871
reactant: 027859
notes: Notes by CellDesigner PMID: 11883315
fast: false
reversible: false

027871
type: SpeciesReference
stoichiometry: 1.0
species: 299468

299468
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: FSHR

027859
type: SpeciesReference
stoichiometry: 1.0
species: 299309

299847
type: Reaction
modifier: 019811
product: 019799
reactant: 019787
notes: PMID: 8832394
fast: false
reversible: false

019799
type: SpeciesReference
stoichiometry: 1.0
species: 298835

019787
type: SpeciesReference
stoichiometry: 1.0
species: 298827

300770
type: Reaction
product: 029371
reactant: 029359
notes: Notes by CellDesigner PMID: 15014447 reaction: direct
fast: false
reversible: false

029371
type: SpeciesReference
stoichiometry: 1.0
species: 299685

299685
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CCNE1

029359
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300192
type: Reaction
modifier: 023978
modifier: 023966
product: 023954
reactant: 023942
notes: Degradation during G1 by APC/C(FZR1) PMID: 15840442 PMID: 15577895 Degradation during M by APC/C(CDC20) PMID: 15577895
fast: false
reversible: false

023954
type: SpeciesReference
stoichiometry: 1.0
species: 299209

299209
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: a38_degraded

023942
type: SpeciesReference
stoichiometry: 1.0
species: 299191

300819
type: Reaction
product: 029827
reactant: 029815
notes: Notes by CellDesigner PMID: 11564866 reaction: direct
fast: false
reversible: false

029827
type: SpeciesReference
stoichiometry: 1.0
species: 299483

029815
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301099
type: Reaction
product: 032246
reactant: 032234
notes: PMID: 12625370
fast: false
reversible: false

032246
type: SpeciesReference
stoichiometry: 1.0
species: 299665

299665
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TP53

032234
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301237
type: Reaction
product: 033542
reactant: 033530
notes: PMID: 12909625
fast: false
reversible: false

033542
type: SpeciesReference
stoichiometry: 1.0
species: 299772

033530
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301181
type: Reaction
product: 033014
reactant: 033002
notes: Notes by CellDesigner PMID: 12446714 reaction: direct
fast: false
reversible: false

033014
type: SpeciesReference
stoichiometry: 1.0
species: 299741

033002
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300532
type: Reaction
product: 027247
reactant: 027235
notes: PMID: 12438307
fast: false
reversible: false

027247
type: SpeciesReference
stoichiometry: 1.0
species: 299689

027235
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300411
type: Reaction
product: 026398
reactant: 026385
notes: PMID: 16144839
fast: false
reversible: false

026398
type: SpeciesReference
stoichiometry: 1.0
species: 299503

026385
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300034
type: Reaction
product: 022207
reactant: 022195
reactant: 022183
notes: The complex cyclinD-CDK stability increases when bound to a Cip/Kip family member. PMID: 10385618
fast: false
reversible: false

022207
type: SpeciesReference
stoichiometry: 1.0
species: 299093

022195
type: SpeciesReference
stoichiometry: 1.0
species: 299091

299091
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK6/cyclin D1*

022183
type: SpeciesReference
stoichiometry: 1.0
species: 299088

300677
type: Reaction
product: 028519
reactant: 028507
notes: PMID: 15510213
fast: false
reversible: false

028519
type: SpeciesReference
stoichiometry: 1.0
species: 299432

028507
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300763
type: Reaction
product: 029299
reactant: 029287
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

029299
type: SpeciesReference
stoichiometry: 1.0
species: 299585

029287
type: SpeciesReference
stoichiometry: 1.0
species: 299838

299606
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ASK

300209
type: Reaction
modifier: 024206
product: 024194
reactant: 024182
fast: false
reversible: false

024194
type: SpeciesReference
stoichiometry: 1.0
species: 299233

299233
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK2/cyclin E1*

024182
type: SpeciesReference
stoichiometry: 1.0
species: 299224

300591
type: Reaction
product: 027775
reactant: 027763
notes: Notes by CellDesigner PMID: 14633988 reaction: direct
fast: false
reversible: false

027775
type: SpeciesReference
stoichiometry: 1.0
species: 299556

027763
type: SpeciesReference
stoichiometry: 1.0
species: 299663

300391
type: Reaction
product: 026223
reactant: 026211
notes: PMID: 10766737
fast: false
reversible: false

026223
type: SpeciesReference
stoichiometry: 1.0
species: 299556

026211
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299446
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ATP5J

301307
type: Reaction
product: 034166
reactant: 034154
notes: PMID: 16512785
fast: false
reversible: false

034166
type: SpeciesReference
stoichiometry: 1.0
species: 299606

034154
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300232
type: Reaction
product: 024494
reactant: 024482
notes: CDK7 activation by its phosphorylation at Thr-170 PMID: 11355576
fast: false
reversible: false

024494
type: SpeciesReference
stoichiometry: 1.0
species: 299171

024482
type: SpeciesReference
stoichiometry: 1.0
species: 299255

301221
type: Reaction
product: 033398
reactant: 033386
notes: Notes by CellDesigner PMID: 10733529 PMID: 15574595 reaction: direct
fast: false
reversible: false

033398
type: SpeciesReference
stoichiometry: 1.0
species: 299765

033386
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300584
type: Reaction
product: 027727
reactant: 027715
fast: false
reversible: false

027727
type: SpeciesReference
stoichiometry: 1.0
species: 299645

299645
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SERPINE1

027715
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300123
type: Reaction
product: 023150
reactant: 023138
notes: PMID: 10373560 (from REACTOME) PMID: 11063929
fast: false
reversible: false

023150
type: SpeciesReference
stoichiometry: 1.0
species: 299166

023138
type: SpeciesReference
stoichiometry: 1.0
species: 299173

300079
type: Reaction
product: 022682
reactant: 022670
reactant: 022657
notes: 12836612
fast: false
reversible: false

022682
type: SpeciesReference
stoichiometry: 1.0
species: 298971

022670
type: SpeciesReference
stoichiometry: 1.0
species: 299097

022657
type: SpeciesReference
stoichiometry: 1.0
species: 299825

299637
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BARD1

300447
type: Reaction
product: 026695
reactant: 026683
notes: PMID: 14532106
fast: false
reversible: false

026695
type: SpeciesReference
stoichiometry: 1.0
species: 299416

026683
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300200
type: Reaction
product: 024098
reactant: 024086
reactant: 024074
notes: (ref REACTOME) PMID: 7799941
fast: false
reversible: false

024098
type: SpeciesReference
stoichiometry: 1.0
species: 299224

024086
type: SpeciesReference
stoichiometry: 1.0
species: 299204

299204
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*

024074
type: SpeciesReference
stoichiometry: 1.0
species: 299193

300086
type: Reaction
product: 022730
reactant: 022718
notes: PMID: 10373560 PMID: 10395539 (from REACTOME) PMID: 11063929
fast: false
reversible: false

022730
type: SpeciesReference
stoichiometry: 1.0
species: 299162

022718
type: SpeciesReference
stoichiometry: 1.0
species: 299177

300084
type: Reaction
product: 022706
reactant: 022694
fast: false
reversible: false

022706
type: SpeciesReference
stoichiometry: 1.0
species: 299137

299137
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: PKMYT1

022694
type: SpeciesReference
stoichiometry: 1.0
species: 299135

301072
type: Reaction
product: 031982
reactant: 031969
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false

031982
type: SpeciesReference
stoichiometry: 1.0
species: 299567

031969
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300715
type: Reaction
product: 028879
reactant: 028867
notes: Notes by CellDesigner PMID: 15574337 reaction: direct
fast: false
reversible: false

028879
type: SpeciesReference
stoichiometry: 1.0
species: 299486

028867
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300338
type: Reaction
product: 025743
reactant: 025731
notes: PMID: 12015319
fast: false
reversible: false

025743
type: SpeciesReference
stoichiometry: 1.0
species: 299606

025731
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301038
type: Reaction
product: 031645
reactant: 031633
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

031645
type: SpeciesReference
stoichiometry: 1.0
species: 299650

031633
type: SpeciesReference
stoichiometry: 1.0
species: 298923

301298
type: Reaction
product: 034094
reactant: 034082
notes: PMID: 15574595
fast: false
reversible: false

034094
type: SpeciesReference
stoichiometry: 1.0
species: 299667

034082
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300107
type: Reaction
modifier: 023006
product: 022994
reactant: 022982
notes: Dephosphorylation of CDC2 induces its activation. PMID: 10373560 PMID: 8348613 PMID: 12814430
fast: false
reversible: false

022994
type: SpeciesReference
stoichiometry: 1.0
species: 299175

022982
type: SpeciesReference
stoichiometry: 1.0
species: 299177

300277
type: Reaction
product: 025058
reactant: 025046
reactant: 025034
fast: false
reversible: false

025058
type: SpeciesReference
stoichiometry: 1.0
species: 299293

025046
type: SpeciesReference
stoichiometry: 1.0
species: 299280

299280
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: NBS1

025034
type: SpeciesReference
stoichiometry: 1.0
species: 298847

300783
type: Reaction
product: 029491
reactant: 029479
notes: PMID: 10030670
fast: false
reversible: false

029491
type: SpeciesReference
stoichiometry: 1.0
species: 299425

029479
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300613
type: Reaction
product: 027991
reactant: 027979
notes: PMID: 12771133
fast: false
reversible: false

027991
type: SpeciesReference
stoichiometry: 1.0
species: 299432

027979
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300091
type: Reaction
modifier: 022802
product: 022790
reactant: 022778
notes: dephosphorylation of CDC2 induce its activation PMID: 10373560 PMID: 8348613 PMID: 12814430
fast: false
reversible: false

022790
type: SpeciesReference
stoichiometry: 1.0
species: 299157

022778
type: SpeciesReference
stoichiometry: 1.0
species: 299162

298868
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1

299890
type: Reaction
product: 020328
product: 020316
reactant: 020304
fast: false
reversible: false

020328
type: SpeciesReference
stoichiometry: 1.0
species: 298877

020316
type: SpeciesReference
stoichiometry: 1.0
species: 298813

020304
type: SpeciesReference
stoichiometry: 1.0
species: 298883

300354
type: Reaction
product: 025887
reactant: 025875
notes: PMID: 11559537 PMID: 11704823
fast: false
reversible: false

025887
type: SpeciesReference
stoichiometry: 1.0
species: 299574

025875
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300916
type: Reaction
product: 030541
reactant: 030528
notes: Notes by CellDesigner PMID: 12077144 reaction: direct
fast: false
reversible: false

030541
type: SpeciesReference
stoichiometry: 1.0
species: 299423

030528
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300282
type: Reaction
modifier: 025143
modifier: 025131
product: 025119
reactant: 025107
notes: Inactivated by phosphorylation by CHEK1 and CHEK2 PMID: 12478465 PMID: 12814430 (ref REACTOME) PMID: 9278512 PMID: 9836640 PMID: 9889122 Phosphorylation by CyclinB-CDC2 PMID: 11313986 ? => concerns CDC25A
fast: false
reversible: false

025119
type: SpeciesReference
stoichiometry: 1.0
species: 299304

025107
type: SpeciesReference
stoichiometry: 1.0
species: 299188

301196
type: Reaction
product: 033158
reactant: 033146
notes: Notes by CellDesigner PMID: 15195143 reaction: direct
fast: false
reversible: false

033158
type: SpeciesReference
stoichiometry: 1.0
species: 299750

033146
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300909
type: Reaction
product: 030463
reactant: 030450
notes: Notes by CellDesigner PMID: 10766737 reaction: direct
fast: false
reversible: false

030463
type: SpeciesReference
stoichiometry: 1.0
species: 299556

030450
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300914
type: Reaction
product: 030515
reactant: 030502
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false

030515
type: SpeciesReference
stoichiometry: 1.0
species: 299507

030502
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299790
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: MDM2

300963
type: Reaction
product: 030901
reactant: 030889
notes: Notes by CellDesigner PMID: 16144839PMID: 14990995
fast: false
reversible: false

030901
type: SpeciesReference
stoichiometry: 1.0
species: 299505

299505
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDT1

030889
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300536
type: Reaction
product: 027271
reactant: 027259
notes: PMID: 12444919
fast: false
reversible: false

027271
type: SpeciesReference
stoichiometry: 1.0
species: 299386

299386
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MXD3

027259
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300415
type: Reaction
product: 026424
reactant: 026411
notes: PMID: 15304485
fast: false
reversible: false

026424
type: SpeciesReference
stoichiometry: 1.0
species: 299418

026411
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300159
type: Reaction
product: 023582
reactant: 023570
notes: PMID: 11355576
fast: false
reversible: false

023582
type: SpeciesReference
stoichiometry: 1.0
species: 299155

299155
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC2

023570
type: SpeciesReference
stoichiometry: 1.0
species: 299148

300252
type: Reaction
modifier: 024722
product: 024710
reactant: 024698
notes: Phosphorylation initiated by E2F1. PMID: 15024084 E2F1 stimulates ATM to phosphorylate p53 (and Chk2) PMID: 15140942 (ref REACTOME) PMID: 12773400 PMID: 10973490
fast: false
reversible: false

024710
type: SpeciesReference
stoichiometry: 1.0
species: 298842

024698
type: SpeciesReference
stoichiometry: 1.0
species: 299335

299867
type: Reaction
product: 020064
reactant: 020052
reactant: 020040
fast: false
reversible: false

020064
type: SpeciesReference
stoichiometry: 1.0
species: 298874

020052
type: SpeciesReference
stoichiometry: 1.0
species: 298810

020040
type: SpeciesReference
stoichiometry: 1.0
species: 298877

300790
type: Reaction
product: 029563
reactant: 029551
notes: Notes by CellDesigner PMID: 10733529 PMID: 15014447 reaction: direct
fast: false
reversible: false

029563
type: SpeciesReference
stoichiometry: 1.0
species: 299598

029551
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300839
type: Reaction
product: 029899
reactant: 029887
notes: Notes by CellDesigner p14 ARF repressed by E2F3b PMID: 15177020 PMID: 15175242 reaction: direct
fast: false
reversible: false

029899
type: SpeciesReference
stoichiometry: 1.0
species: 299380

029887
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300767
type: Reaction
product: 029347
reactant: 029335
notes: PMID: 8618861 PMID: 10733529
fast: false
reversible: false

029347
type: SpeciesReference
stoichiometry: 1.0
species: 299671

029335
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300972
type: Reaction
product: 030997
reactant: 030985
notes: Notes by CellDesigner PMID: 15580623 reaction: direct
fast: false
reversible: false

030997
type: SpeciesReference
stoichiometry: 1.0
species: 299621

299621
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: FGFR1

030985
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299350
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: E2F2

299619
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: HOXA3

299632
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CHEK1

299499
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: DNMT1

300658
type: Reaction
product: 028351
reactant: 028339
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

028351
type: SpeciesReference
stoichiometry: 1.0
species: 299459

028339
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300229
type: Reaction
modifier: 024470
product: 024458
reactant: 024446
notes: CDK activity stimulated by its CAK-complex phosphorylation. PMID: 12459251 PMID: 12814430 (ref REACTOME) PMID: 16782892
fast: false
reversible: false

024458
type: SpeciesReference
stoichiometry: 1.0
species: 298965

024446
type: SpeciesReference
stoichiometry: 1.0
species: 299095

299095
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK4/CDKN1B

301092
type: Reaction
product: 032174
reactant: 032162
fast: false
reversible: false

032174
type: SpeciesReference
stoichiometry: 1.0
species: 299840

032162
type: SpeciesReference
stoichiometry: 1.0
species: 299661

300399
type: Reaction
product: 026297
reactant: 026285
notes: PMID: 12077144
fast: false
reversible: false

026297
type: SpeciesReference
stoichiometry: 1.0
species: 299423

026285
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300588
type: Reaction
product: 027751
reactant: 027739
notes: Notes by CellDesigner PMID: 14633988
fast: false
reversible: false

027751
type: SpeciesReference
stoichiometry: 1.0
species: 299685

027739
type: SpeciesReference
stoichiometry: 1.0
species: 299663

301311
type: Reaction
product: 034214
reactant: 034202
fast: false
reversible: false

034214
type: SpeciesReference
stoichiometry: 1.0
species: 299674

034202
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300674
type: Reaction
product: 028495
reactant: 028483
notes: Notes by CellDesigner PMID: 15271987
fast: false
reversible: false

028495
type: SpeciesReference
stoichiometry: 1.0
species: 299516

028483
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300665
type: Reaction
product: 028423
reactant: 028411
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

028423
type: SpeciesReference
stoichiometry: 1.0
species: 299647

028411
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300297
type: Reaction
product: 025275
product: 025263
reactant: 025251
notes: MDM2 = ubiquitin-ligase, regulates p53 stability: induice its degradation via the proteasome. PMID: 15024084
fast: false
reversible: false

025275
type: SpeciesReference
stoichiometry: 1.0
species: 299794

299794
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: MDM2

025263
type: SpeciesReference
stoichiometry: 1.0
species: 299322

025251
type: SpeciesReference
stoichiometry: 1.0
species: 299330

299330
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p53*/MDM2

299389
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MYB

299956
type: Reaction
modifier: 021193
product: 021181
reactant: 021169
notes: Induce the G0 to G1 transition: phosphorylated pocket proteins stop repressing ribosomal RNA and tRNA gene expression. PMID: 15838516
fast: false
reversible: false

021181
type: SpeciesReference
stoichiometry: 1.0
species: 298985

021169
type: SpeciesReference
stoichiometry: 1.0
species: 298956

301157
type: Reaction
product: 032774
reactant: 032762
fast: false
reversible: false

032774
type: SpeciesReference
stoichiometry: 1.0
species: 299717

299717
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SLC3A2

032762
type: SpeciesReference
stoichiometry: 1.0
species: 298923

301085
type: Reaction
product: 032102
reactant: 032090
notes: Notes by CellDesigner PMID: 16179649
fast: false
reversible: false

032102
type: SpeciesReference
stoichiometry: 1.0
species: 299339

032090
type: SpeciesReference
stoichiometry: 1.0
species: 299311

300896
type: Reaction
product: 030335
reactant: 030323
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

030335
type: SpeciesReference
stoichiometry: 1.0
species: 299435

299435
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CBX5

030323
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300889
type: Reaction
product: 030260
reactant: 030248
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

030260
type: SpeciesReference
stoichiometry: 1.0
species: 299512

030248
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300143
type: Reaction
modifier: 023378
product: 023366
reactant: 023354
notes: Phosphorylation only when CDC2 is bound to the cyclin D. PMID: 10373560 PMID: 9001210 PMID: 12814430
fast: false
reversible: false

023366
type: SpeciesReference
stoichiometry: 1.0
species: 299180

023354
type: SpeciesReference
stoichiometry: 1.0
species: 299173

300015
type: Reaction
product: 021949
reactant: 021937
reactant: 021925
notes: (ref REACTOME) PMID: 8078588 PMID: 8741839 PMID: 8001816 PMID: 8259215
fast: false
reversible: false

021949
type: SpeciesReference
stoichiometry: 1.0
species: 299067

299067
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK6/CDKN2B

021937
type: SpeciesReference
stoichiometry: 1.0
species: 299058

021925
type: SpeciesReference
stoichiometry: 1.0
species: 299044

300428
type: Reaction
product: 026551
reactant: 026539
notes: PMID: 16158053
fast: false
reversible: false

026551
type: SpeciesReference
stoichiometry: 1.0
species: 299470

026539
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299887
type: Reaction
modifier: 020292
product: 020280
reactant: 020268
notes: p14ARF induce the degradation of E2F1, E2F2 and E2F3 via the proteasome PMID: 11274364
fast: false
reversible: false

020280
type: SpeciesReference
stoichiometry: 1.0
species: 298851

020268
type: SpeciesReference
stoichiometry: 1.0
species: 298863

300099
type: Reaction
product: 022898
reactant: 022886
notes: PMID: 10373560 The NES (nuclear export signal) of the cyclin B allows its active export. Export via the CRM1 complex, seems to need GTPaseRan/TC4 PMID: 9679058 (ref REACTOME) PMID: 9670027 PMID: 9679058
fast: false
reversible: false

022898
type: SpeciesReference
stoichiometry: 1.0
species: 299177

022886
type: SpeciesReference
stoichiometry: 1.0
species: 299162

299455
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ESR1

300992
type: Reaction
product: 031189
reactant: 031177
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false

031189
type: SpeciesReference
stoichiometry: 1.0
species: 299548

031177
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300703
type: Reaction
product: 028759
reactant: 028747
notes: Notes by CellDesigner PMID: 10766737 reaction: direct
fast: false
reversible: false

028759
type: SpeciesReference
stoichiometry: 1.0
species: 299339

028747
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300873
type: Reaction
product: 030115
reactant: 030103
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false

030115
type: SpeciesReference
stoichiometry: 1.0
species: 299639

299639
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ACR

030103
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300864
type: Reaction
product: 030019
reactant: 030007
notes: Notes by CellDesigner PMID: 15731768
fast: false
reversible: false

030019
type: SpeciesReference
stoichiometry: 1.0
species: 299594

030007
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301356
type: Reaction
product: 034697
reactant: 034684
fast: false
reversible: false

034697
type: SpeciesReference
stoichiometry: 1.0
species: 299663

034684
type: SpeciesReference
stoichiometry: 1.0
species: 299578

299578
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F7 cofactors

301286
type: Reaction
product: 033974
reactant: 033962
notes: PMID: 12368233
fast: false
reversible: false

033974
type: SpeciesReference
stoichiometry: 1.0
species: 299810

033962
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300074
type: Reaction
product: 022609
reactant: 022597
notes: degradation of cyclin D via the ubiquitin-proteasome system PMID: 9736735
fast: false
reversible: false

022609
type: SpeciesReference
stoichiometry: 1.0
species: 299086

022597
type: SpeciesReference
stoichiometry: 1.0
species: 299084

300249
type: Reaction
product: 024686
reactant: 024674
reactant: 024662
notes: PMID: 15798220
fast: false
reversible: false

024686
type: SpeciesReference
stoichiometry: 1.0
species: 299272

299272
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin B1*/CDC2/CDKN1A

024674
type: SpeciesReference
stoichiometry: 1.0
species: 299823

024662
type: SpeciesReference
stoichiometry: 1.0
species: 299168

299168
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin B1*/CDC2

299652
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RPL32

300710
type: Reaction
product: 028831
reactant: 028819
notes: Notes by CellDesigner PMID: 14532106
fast: false
reversible: false

028831
type: SpeciesReference
stoichiometry: 1.0
species: 299416

028819
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300880
type: Reaction
product: 030163
reactant: 030151
notes: Notes by CellDesigner PMID: 15033491 reaction: direct
fast: false
reversible: false

030163
type: SpeciesReference
stoichiometry: 1.0
species: 299518

030151
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299278
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: NBS1

300976
type: Reaction
product: 031045
reactant: 031033
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false

031045
type: SpeciesReference
stoichiometry: 1.0
species: 299619

031033
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300524
type: Reaction
product: 027175
reactant: 027163
notes: PMID: 8137237 PMID: 10567569
fast: false
reversible: false

027175
type: SpeciesReference
stoichiometry: 1.0
species: 299389

027163
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300519
type: Reaction
product: 027127
reactant: 027115
notes: PMID: 15195143
fast: false
reversible: false

027127
type: SpeciesReference
stoichiometry: 1.0
species: 299391

027115
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301347
type: Reaction
product: 034619
reactant: 034607
fast: false
reversible: false

034619
type: SpeciesReference
stoichiometry: 1.0
species: 298923

034607
type: SpeciesReference
stoichiometry: 1.0
species: 299477

300517
type: Reaction
product: 027103
reactant: 027091
notes: PMID: 14990995
fast: false
reversible: false

027103
type: SpeciesReference
stoichiometry: 1.0
species: 299683

027091
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301291
type: Reaction
product: 034022
reactant: 034010
notes: PMID: 12368233
fast: false
reversible: false

034022
type: SpeciesReference
stoichiometry: 1.0
species: 299810

034010
type: SpeciesReference
stoichiometry: 1.0
species: 298923

298939
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p130*/E2F4/DP2*

299976
type: Reaction
product: 021445
reactant: 021433
notes: PMID: 15536069
fast: false
reversible: false

021445
type: SpeciesReference
stoichiometry: 1.0
species: 299845

021433
type: SpeciesReference
stoichiometry: 1.0
species: 299042

299042
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F6/DP1*

300195
type: Reaction
modifier: 024026
modifier: 024014
product: 024002
reactant: 023990
notes: PMID: 10548110 (ref REACTOME) PMID: 11598127 (CycB phosphorylates CDH1)
fast: false
reversible: false

024002
type: SpeciesReference
stoichiometry: 1.0
species: 299215

023990
type: SpeciesReference
stoichiometry: 1.0
species: 299213

300825
type: Reaction
product: 029875
reactant: 029863
notes: Notes by CellDesigner PMID: 12665581
fast: false
reversible: false

029875
type: SpeciesReference
stoichiometry: 1.0
species: 299384

029863
type: SpeciesReference
stoichiometry: 1.0
species: 299838

299139
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC20

300902
type: Reaction
product: 030385
reactant: 030373
notes: PMID: 15510213
fast: false
reversible: false

030385
type: SpeciesReference
stoichiometry: 1.0
species: 299559

030373
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300326
type: Reaction
product: 025623
reactant: 025611
notes: PMID: 9819415
fast: false
reversible: false

025623
type: SpeciesReference
stoichiometry: 1.0
species: 299790

025611
type: SpeciesReference
stoichiometry: 1.0
species: 299794

301001
type: Reaction
product: 031285
reactant: 031273
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false

031285
type: SpeciesReference
stoichiometry: 1.0
species: 299545

299545
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: METAP2

031273
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300163
type: Reaction
modifier: 023618
product: 023606
reactant: 023594
notes: Inactivated by phosphorylation by CHEK1 and CHEK2 PMID: 12478465 PMID: 12814430 Phosphorylation by CyclinB-CDC2 PMID: 11313986 ? => concerns CDC25A
fast: false
reversible: false

023606
type: SpeciesReference
stoichiometry: 1.0
species: 299188

023594
type: SpeciesReference
stoichiometry: 1.0
species: 299184

300156
type: Reaction
product: 023558
product: 023546
reactant: 023534
fast: false
reversible: false

023558
type: SpeciesReference
stoichiometry: 1.0
species: 299144

023546
type: SpeciesReference
stoichiometry: 1.0
species: 299148

023534
type: SpeciesReference
stoichiometry: 1.0
species: 299168

299992
type: Reaction
product: 021673
reactant: 021661
reactant: 021649
notes: PMID: 12004135 PMID: 15536069 PMID: 15126619
fast: false
reversible: false

021673
type: SpeciesReference
stoichiometry: 1.0
species: 299035

021661
type: SpeciesReference
stoichiometry: 1.0
species: 299845

021649
type: SpeciesReference
stoichiometry: 1.0
species: 299038

299600
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CYC

299401
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: LGALS1

299475
type: Species
notes: Needs verification: which form of CDC25 gets phosphorylated on Ser216 by Chek1,2???
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F6 cofactors

300464
type: Reaction
product: 026839
reactant: 026827
notes: PMID: 11883315
fast: false
reversible: false

026839
type: SpeciesReference
stoichiometry: 1.0
species: 299468

026827
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300042
type: Reaction
modifier: 022308
product: 022295
reactant: 022282
notes: PMID: 12459251 PMID: 10385618 (ref REACTOME) PMID: 16732330
fast: false
reversible: false

022295
type: SpeciesReference
stoichiometry: 1.0
species: 299101

022282
type: SpeciesReference
stoichiometry: 1.0
species: 299091

300569
type: Reaction
product: 027583
reactant: 027571
notes: PMID: 12909625
fast: false
reversible: false

027583
type: SpeciesReference
stoichiometry: 1.0
species: 299369

027571
type: SpeciesReference
stoichiometry: 1.0
species: 299840

299676
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: uPA

301145
type: Reaction
product: 032678
reactant: 032666
notes: PMID: 16325355
fast: false
reversible: false

032678
type: SpeciesReference
stoichiometry: 1.0
species: 299701

032666
type: SpeciesReference
stoichiometry: 1.0
species: 299843

301068
type: Reaction
product: 031933
reactant: 031921
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

031933
type: SpeciesReference
stoichiometry: 1.0
species: 299647

031921
type: SpeciesReference
stoichiometry: 1.0
species: 298923

301150
type: Reaction
product: 032726
reactant: 032714
notes: PMID: 16325355
fast: false
reversible: false

032726
type: SpeciesReference
stoichiometry: 1.0
species: 299701

032714
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300996
type: Reaction
product: 031237
reactant: 031225
notes: Notes by CellDesigner PMID: 14990995 reaction: indirect intermediate: MYC
fast: false
reversible: false

031237
type: SpeciesReference
stoichiometry: 1.0
species: 299683

031225
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300718
type: Reaction
product: 028903
reactant: 028891
notes: Notes by CellDesigner PMID: 14990995 reaction: direct
fast: false
reversible: false

028903
type: SpeciesReference
stoichiometry: 1.0
species: 299410

028891
type: SpeciesReference
stoichiometry: 1.0
species: 299843

299816
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BRD7

300115
type: Reaction
modifier: 023078
product: 023066
reactant: 023054
notes: Dephosphorylation of CDC2 induces its activation. PMID: 10373560 PMID: 8348613 PMID: 12814430
fast: false
reversible: false

023066
type: SpeciesReference
stoichiometry: 1.0
species: 299173

023054
type: SpeciesReference
stoichiometry: 1.0
species: 299175

300285
type: Reaction
product: 025167
reactant: 025155
notes: PMID: 12210082 PMID: 10498883
fast: false
reversible: false

025167
type: SpeciesReference
stoichiometry: 1.0
species: 299302

299302
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298791
name: p14ARF*/MDM2

025155
type: SpeciesReference
stoichiometry: 1.0
species: 299300

299951
type: Reaction
product: 021121
reactant: 021109
reactant: 021097
notes: PMID: 11533237 PMID: 11484059 PMID: 15126619 PMID: 11420729 PMID: 15838516
fast: false
reversible: false

021121
type: SpeciesReference
stoichiometry: 1.0
species: 298989

021109
type: SpeciesReference
stoichiometry: 1.0
species: 298956

021097
type: SpeciesReference
stoichiometry: 1.0
species: 298908

300639
type: Reaction
product: 028183
reactant: 028171
notes: Notes by CellDesigner PMID: 12004135 reaction: direct
fast: false
reversible: false

028183
type: SpeciesReference
stoichiometry: 1.0
species: 299339

028171
type: SpeciesReference
stoichiometry: 1.0
species: 299313

301075
type: Reaction
product: 032006
reactant: 031994
notes: PMID: 16179649
fast: false
reversible: false

032006
type: SpeciesReference
stoichiometry: 1.0
species: 299432

031994
type: SpeciesReference
stoichiometry: 1.0
species: 299311

301129
type: Reaction
product: 032510
reactant: 032498
fast: false
reversible: false

032510
type: SpeciesReference
stoichiometry: 1.0
species: 299676

032498
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300893
type: Reaction
product: 030310
reactant: 030298
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

030310
type: SpeciesReference
stoichiometry: 1.0
species: 299367

030298
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300723
type: Reaction
product: 028927
reactant: 028915
notes: Notes by CellDesigner PMID: 14990995 reaction: indirect intermediate: MYC
fast: false
reversible: false

028927
type: SpeciesReference
stoichiometry: 1.0
species: 299683

028915
type: SpeciesReference
stoichiometry: 1.0
species: 299843

299481
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: p180*

300290
type: Reaction
product: 025215
reactant: 025203
notes: E2F1 sequestrated by ARF in the nucleolus. PMID: 16135794 PMID: 12446760
fast: false
reversible: false

025215
type: SpeciesReference
stoichiometry: 1.0
species: 299307

025203
type: SpeciesReference
stoichiometry: 1.0
species: 298894

299732
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SRPR

301206
type: Reaction
product: 033230
reactant: 033218
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false

033230
type: SpeciesReference
stoichiometry: 1.0
species: 299754

033218
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300553
type: Reaction
product: 027439
reactant: 027427
fast: false
reversible: false

027439
type: SpeciesReference
stoichiometry: 1.0
species: 299481

027427
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300609
type: Reaction
product: 027967
reactant: 027955
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

027967
type: SpeciesReference
stoichiometry: 1.0
species: 299435

027955
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300432
type: Reaction
product: 026575
reactant: 026563
notes: PMID: 15867357
fast: false
reversible: false

026575
type: SpeciesReference
stoichiometry: 1.0
species: 299499

026563
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300131
type: Reaction
product: 023246
reactant: 023234
notes: PMID: 10373560 PMID: 10395539 (from REACTOME) PMID: 11063929
fast: false
reversible: false

023246
type: SpeciesReference
stoichiometry: 1.0
species: 299164

023234
type: SpeciesReference
stoichiometry: 1.0
species: 299180

300003
type: Reaction
product: 021793
reactant: 021781
reactant: 021769
notes: PMID: 11171983
fast: false
reversible: false

021793
type: SpeciesReference
stoichiometry: 1.0
species: 299024

299024
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: RYBP/RING1/MEL-18*/_br_PHC1/BMI1*/E2F6/DP2*

021781
type: SpeciesReference
stoichiometry: 1.0
species: 299029

021769
type: SpeciesReference
stoichiometry: 1.0
species: 299027

300423
type: Reaction
product: 026502
reactant: 026489
notes: PMID: 12909625
fast: false
reversible: false

026502
type: SpeciesReference
stoichiometry: 1.0
species: 299501

026489
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300698
type: Reaction
product: 028711
reactant: 028699
notes: Notes by CellDesigner PMID: 16144839
fast: false
reversible: false

028711
type: SpeciesReference
stoichiometry: 1.0
species: 299503

028699
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300959
type: Reaction
product: 030853
reactant: 030841
notes: Notes by CellDesigner PMID: 14532106 reaction: direct
fast: false
reversible: false

030853
type: SpeciesReference
stoichiometry: 1.0
species: 299416

030841
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300362
type: Reaction
product: 025959
reactant: 025947
notes: PMID: 12909625
fast: false
reversible: false

025959
type: SpeciesReference
stoichiometry: 1.0
species: 299512

025947
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300861
type: Reaction
product: 029995
reactant: 029983
notes: Notes by CellDesigner PMID: 12110166
fast: false
reversible: false

029995
type: SpeciesReference
stoichiometry: 1.0
species: 299596

029983
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301014
type: Reaction
product: 031405
reactant: 031393
notes: Notes by CellDesigner PMID: 10766737 PMID: 8760872 reaction: direct
fast: false
reversible: false

031405
type: SpeciesReference
stoichiometry: 1.0
species: 299462

031393
type: SpeciesReference
stoichiometry: 1.0
species: 298923

301351
type: Reaction
product: 034671
reactant: 034658
fast: false
reversible: false

034671
type: SpeciesReference
stoichiometry: 1.0
species: 299309

034658
type: SpeciesReference
stoichiometry: 1.0
species: 299576

300169
type: Reaction
modifier: 023690
product: 023678
reactant: 023666
notes: PMID: 10385618 PMID: 12459251
fast: false
reversible: false

023678
type: SpeciesReference
stoichiometry: 1.0
species: 299195

299195
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: GSK3B

023666
type: SpeciesReference
stoichiometry: 1.0
species: 299070

299257
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: a701_degraded

301328
type: Reaction
product: 034408
reactant: 034396
reactant: 034384
notes: p107 binds to and inhibits cyclinA-CDK2, independantly of its phosphorylation state. PMID: 15456871 PMID: 12006580 PMID: 11237530
fast: false
reversible: false

034408
type: SpeciesReference
stoichiometry: 1.0
species: 299829

299829
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin A2*/CDK2/p107

034396
type: SpeciesReference
stoichiometry: 1.0
species: 298958

034384
type: SpeciesReference
stoichiometry: 1.0
species: 298910

301274
type: Reaction
product: 033878
reactant: 033866
notes: PMID: 16580749
fast: false
reversible: false

033878
type: SpeciesReference
stoichiometry: 1.0
species: 299786

033866
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301272
type: Reaction
product: 033854
reactant: 033842
notes: PMID: 16580749
fast: false
reversible: false

033854
type: SpeciesReference
stoichiometry: 1.0
species: 299786

033842
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300039
type: Reaction
product: 022269
reactant: 022257
notes: PMID: 12459251 PMID: 10385618 T286 phosphorylation promote association of cyclin D1 with its nuclear exporter CRM1, leading to cytoplasmic translocation of cylcin D1 PMID: 12851486
fast: false
reversible: false

022269
type: SpeciesReference
stoichiometry: 1.0
species: 299108

022257
type: SpeciesReference
stoichiometry: 1.0
species: 299104

299875
type: Reaction
product: 020148
reactant: 020136
fast: false
reversible: false

020148
type: SpeciesReference
stoichiometry: 1.0
species: 298835

020136
type: SpeciesReference
stoichiometry: 1.0
species: 298824

298824
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: DP1*

299914
type: Reaction
fast: false
reactant: 020533
modifier: 020605
modifier: 020569
reversible: false
notes: PMID: 12006580
modifier: 020581
modifier: 020593
product: 020545
modifier: 020557

020533
type: SpeciesReference
stoichiometry: 1.0
species: 298949

020545
type: SpeciesReference
stoichiometry: 1.0
species: 298933

301120
type: Reaction
product: 032438
reactant: 032426
notes: PMID: 12368233
fast: false
reversible: false

032438
type: SpeciesReference
stoichiometry: 1.0
species: 299810

032426
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301113
type: Reaction
product: 032366
reactant: 032354
notes: PMID: 17135268
fast: false
reversible: false

032366
type: SpeciesReference
stoichiometry: 1.0
species: 299703

032354
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301021
type: Reaction
product: 031477
reactant: 031465
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false

031477
type: SpeciesReference
stoichiometry: 1.0
species: 299531

031465
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300922
type: Reaction
product: 030589
reactant: 030577
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false

030589
type: SpeciesReference
stoichiometry: 1.0
species: 299632

030577
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300598
type: Reaction
product: 027847
reactant: 027835
notes: Notes by CellDesigner PMID: 12789259 reaction: direct
fast: false
reversible: false

027847
type: SpeciesReference
stoichiometry: 1.0
species: 299455

027835
type: SpeciesReference
stoichiometry: 1.0
species: 299309

300307
type: Reaction
product: 025383
reactant: 025371
fast: false
reversible: false

025383
type: SpeciesReference
stoichiometry: 1.0
species: 298994

025371
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300521
type: Reaction
product: 027151
reactant: 027139
notes: PMID: 16144839
fast: false
reversible: false

027151
type: SpeciesReference
stoichiometry: 1.0
species: 299554

027139
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301344
type: Reaction
product: 034594
reactant: 034582
fast: false
reversible: false

034594
type: SpeciesReference
stoichiometry: 1.0
species: 299843

034582
type: SpeciesReference
stoichiometry: 1.0
species: 299337

300048
type: Reaction
product: 022360
reactant: 022347
fast: false
reversible: false

022360
type: SpeciesReference
stoichiometry: 1.0
species: 299079

022347
type: SpeciesReference
stoichiometry: 2.0
species: 299077

300512
type: Reaction
product: 027055
reactant: 027043
notes: PMID: 11857079
fast: false
reversible: false

027055
type: SpeciesReference
stoichiometry: 1.0
species: 299396

027043
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300682
type: Reaction
product: 028567
reactant: 028555
notes: Notes by CellDesigner PMID: 12611887
fast: false
reversible: false

028567
type: SpeciesReference
stoichiometry: 1.0
species: 299430

028555
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300237
type: Reaction
product: 024542
reactant: 024530
notes: Phosphorylation of p27 at Thr-157 in its NLS, which impair its nuclear import. PMID: 12851486 (from REACTOME) PMID: 9632134
fast: false
reversible: false

024542
type: SpeciesReference
stoichiometry: 1.0
species: 299259

024530
type: SpeciesReference
stoichiometry: 1.0
species: 299221

300813
type: Reaction
product: 029779
reactant: 029767
notes: Notes by CellDesigner PMID: 16144839
fast: false
reversible: false

029779
type: SpeciesReference
stoichiometry: 1.0
species: 299554

029767
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300323
type: Reaction
reactant: 025551
notes: Upon DNA damage, E2F is stabilized by ATM phosphorylation. PMID: 15838517 PMID: 15140942 14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. PMID: 15494392
fast: false
modifier: 025599
product: 025563
modifier: 025587
reversible: false
product: 025575

025551
type: SpeciesReference
stoichiometry: 1.0
species: 298881

025563
type: SpeciesReference
stoichiometry: 1.0
species: 298899

025575
type: SpeciesReference
stoichiometry: 1.0
species: 298857

301235
type: Reaction
product: 033518
reactant: 033506
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

033518
type: SpeciesReference
stoichiometry: 1.0
species: 299772

033506
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300314
type: Reaction
modifier: 025479
modifier: 025467
product: 025455
reactant: 025443
notes: (from REACTOME) PMID: 8515817 phosphorylation and inactivation of Wee1 kinase PMID: 15070733 PMID: 7681363 (yeast) PMID: 9268380 Cyclin B phosphorylates Myt1 in vitro
fast: false
reversible: false

025455
type: SpeciesReference
stoichiometry: 1.0
species: 299320

025443
type: SpeciesReference
stoichiometry: 1.0
species: 299128

300151
type: Reaction
modifier: 023486
product: 023474
reactant: 023462
notes: PMID: 15840442
fast: false
reversible: false

023474
type: SpeciesReference
stoichiometry: 1.0
species: 299142

023462
type: SpeciesReference
stoichiometry: 1.0
species: 299139

300505
type: Reaction
product: 027007
reactant: 026995
notes: PMID: 15897325
fast: false
reversible: false

027007
type: SpeciesReference
stoichiometry: 1.0
species: 299401

026995
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300128
type: Reaction
modifier: 023222
product: 023210
reactant: 023198
notes: Dephosphorylation of CDC2 induces its activation. PMID: 10373560 PMID: 8348613 PMID: 12814430 (ref REACTOME) PMID: 1828290
fast: false
reversible: false

023210
type: SpeciesReference
stoichiometry: 1.0
species: 299166

023198
type: SpeciesReference
stoichiometry: 1.0
species: 299164

299959
type: Reaction
product: 021229
product: 021217
reactant: 021205
notes: Once the process of methylation has started, pRB is detached from the DNA. PMID: 15126619 OR phosphorylation of RB destroy its binding with SUV39H1 PMID: 11533237
fast: false
reversible: false

021229
type: SpeciesReference
stoichiometry: 1.0
species: 298983

021217
type: SpeciesReference
stoichiometry: 1.0
species: 298956

021205
type: SpeciesReference
stoichiometry: 1.0
species: 298980

300808
type: Reaction
product: 029731
reactant: 029719
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false

029731
type: SpeciesReference
stoichiometry: 1.0
species: 299360

299360
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCM6

029719
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301088
type: Reaction
product: 032126
reactant: 032114
notes: Notes by CellDesigner PMID: 16179649 reaction: direct
fast: false
reversible: false

032126
type: SpeciesReference
stoichiometry: 1.0
species: 299479

032114
type: SpeciesReference
stoichiometry: 1.0
species: 299663

301242
type: Reaction
product: 033590
reactant: 033578
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

033590
type: SpeciesReference
stoichiometry: 1.0
species: 299778

033578
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301170
type: Reaction
product: 032918
reactant: 032906
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false

032918
type: SpeciesReference
stoichiometry: 1.0
species: 299732

032906
type: SpeciesReference
stoichiometry: 1.0
species: 298923

301219
type: Reaction
product: 033374
reactant: 033362
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

033374
type: SpeciesReference
stoichiometry: 1.0
species: 299765

033362
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300557
type: Reaction
product: 027487
reactant: 027475
notes: PMID: 15706352 PMID: 15731768
fast: false
reversible: false

027487
type: SpeciesReference
stoichiometry: 1.0
species: 299594

027475
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301049
type: Reaction
product: 031765
reactant: 031753
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

031765
type: SpeciesReference
stoichiometry: 1.0
species: 299459

031753
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299241
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC14

299895
type: Reaction
modifier: 020400
product: 020388
reactant: 020376
notes: Phosphorylation at the Ser-403 in S phase by the TFIIH kinase targets E2F1 for its rapid ubiquitination and degradation through the ubiquitin-proteasome pathway. PMID: 15123636 Phosphorylation at Ser-403 and Thr-433 by the basal TF TFHII triggers E2F1 degradation. PMID: 16213134
fast: false
reversible: false

020388
type: SpeciesReference
stoichiometry: 1.0
species: 298872

020376
type: SpeciesReference
stoichiometry: 1.0
species: 298863

300221
type: Reaction
product: 024350
reactant: 024338
reactant: 024326
fast: false
reversible: false

024350
type: SpeciesReference
stoichiometry: 1.0
species: 298992

024338
type: SpeciesReference
stoichiometry: 1.0
species: 299246

299246
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin C*

024326
type: SpeciesReference
stoichiometry: 1.0
species: 299243

301133
type: Reaction
product: 032558
reactant: 032546
fast: false
reversible: false

032558
type: SpeciesReference
stoichiometry: 1.0
species: 299678

032546
type: SpeciesReference
stoichiometry: 1.0
species: 299843

301061
type: Reaction
product: 031861
reactant: 031849
notes: PMID: 10766737 PMID: 16135806
fast: false
reversible: false

031861
type: SpeciesReference
stoichiometry: 1.0
species: 299812

031849
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300788
type: Reaction
product: 029539
reactant: 029527
notes: Notes by CellDesigner PMID: 16144839
fast: false
reversible: false

029539
type: SpeciesReference
stoichiometry: 1.0
species: 299503

029527
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300359
type: Reaction
product: 025935
reactant: 025923
notes: PMID: 15271987
fast: false
reversible: false

025935
type: SpeciesReference
stoichiometry: 1.0
species: 299516

025923
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300573
type: Reaction
product: 027631
reactant: 027619
notes: PMID: 15897325
fast: false
reversible: false

027631
type: SpeciesReference
stoichiometry: 1.0
species: 299570

299570
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RBM25

027619
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300452
type: Reaction
product: 026743
reactant: 026731
notes: PMID: 12909625
fast: false
reversible: false

026743
type: SpeciesReference
stoichiometry: 1.0
species: 299494

026731
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300112
type: Reaction
modifier: 023042
product: 023030
reactant: 023018
notes: Phosphorylation only when CDC2 is bound to the cyclin B PMID: 10373560 PMID: 9001210 PMID: 12814430 (ref REACTOME) PMID: 9268380
fast: false
reversible: false

023030
type: SpeciesReference
stoichiometry: 1.0
species: 299175

023018
type: SpeciesReference
stoichiometry: 1.0
species: 299173

300068
type: Reaction
product: 022549
product: 022537
reactant: 022525
fast: false
reversible: false

022549
type: SpeciesReference
stoichiometry: 1.0
species: 299054

022537
type: SpeciesReference
stoichiometry: 1.0
species: 299084

022525
type: SpeciesReference
stoichiometry: 1.0
species: 299108

301018
type: Reaction
product: 031453
reactant: 031441
notes: Notes by CellDesigner PMID: 12438307 reaction: direct
fast: false
reversible: false

031453
type: SpeciesReference
stoichiometry: 1.0
species: 299689

031441
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300629
type: Reaction
product: 028135
reactant: 028123
notes: Notes by CellDesigner PMID: 10998368
fast: false
reversible: false

028135
type: SpeciesReference
stoichiometry: 1.0
species: 299600

028123
type: SpeciesReference
stoichiometry: 1.0
species: 299313

301117
type: Reaction
product: 032414
reactant: 032402
notes: PMID: 16331253
fast: false
reversible: false

032414
type: SpeciesReference
stoichiometry: 1.0
species: 299711

299711
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SKP2

032402
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300343
type: Reaction
product: 025791
reactant: 025779
notes: PMID: 15897325
fast: false
reversible: false

025791
type: SpeciesReference
stoichiometry: 1.0
species: 299446

025779
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301210
type: Reaction
product: 033278
reactant: 033266
notes: PMID: 12838312 PMID: 15361834
fast: false
reversible: false

033278
type: SpeciesReference
stoichiometry: 1.0
species: 299757

033266
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301034
type: Reaction
product: 031597
reactant: 031585
notes: Notes by CellDesigner PMID: 12139485 reaction: direct
fast: false
reversible: false

031597
type: SpeciesReference
stoichiometry: 1.0
species: 299572

031585
type: SpeciesReference
stoichiometry: 1.0
species: 298923

301027
type: Reaction
product: 031549
reactant: 031537
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false

031549
type: SpeciesReference
stoichiometry: 1.0
species: 299656

031537
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299984
type: Reaction
product: 021553
reactant: 021541
reactant: 021529
fast: false
reversible: false

021553
type: SpeciesReference
stoichiometry: 1.0
species: 299042

021541
type: SpeciesReference
stoichiometry: 1.0
species: 298994

021529
type: SpeciesReference
stoichiometry: 1.0
species: 298827

300942
type: Reaction
product: 030733
reactant: 030721
notes: Notes by CellDesigner PMID: 11564866 reaction: direct
fast: false
reversible: false

030733
type: SpeciesReference
stoichiometry: 1.0
species: 299598

030721
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300266
type: Reaction
modifier: 024950
product: 024938
reactant: 024926
reactant: 024914
notes: Phosphorylations on p53 prevent its binding to MDM2. PMID: 15140942 MDM2 phosphorylation by AKT favors the binding of MDM2 to p53 and its following degradation. PMID: 15574337
fast: false
reversible: false

024938
type: SpeciesReference
stoichiometry: 1.0
species: 299298

299298
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p53*/MDM2

024926
type: SpeciesReference
stoichiometry: 1.0
species: 299282

024914
type: SpeciesReference
stoichiometry: 1.0
species: 299790

300271
type: Reaction
modifier: 024986
product: 024974
reactant: 024962
notes: MDM2 phosphorylation by ATM inhibits its interaction with p53 PMID: 15140942 (ref REACTOME) PMID: 11331603 phosphorylation at Ser395
fast: false
reversible: false

024974
type: SpeciesReference
stoichiometry: 1.0
species: 299792

299792
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: MDM2

024962
type: SpeciesReference
stoichiometry: 1.0
species: 299790

299900
type: Reaction
product: 020448
reactant: 020436
notes: E2F4 does not possess the NLS (nuclear localisation signal). Translocation in the nucleus only when bound to DP2 and/or p130/p107. Located in the nucleus only during G0 and G1. PMID: 9372959 PMID: 11959842
fast: false
reversible: false

020448
type: SpeciesReference
stoichiometry: 1.0
species: 298937

020436
type: SpeciesReference
stoichiometry: 1.0
species: 298939

300602
type: Reaction
product: 027895
reactant: 027883
notes: Notes by CellDesigner PMID: 14990995 reaction: direct
fast: false
reversible: false

027895
type: SpeciesReference
stoichiometry: 1.0
species: 299410

027883
type: SpeciesReference
stoichiometry: 1.0
species: 299309

300772
type: Reaction
product: 029395
reactant: 029383
notes: Notes by CellDesigner PMID: 10733529 PMID: 15510213 reaction: direct
fast: false
reversible: false

029395
type: SpeciesReference
stoichiometry: 1.0
species: 299427

029383
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300961
type: Reaction
product: 030877
reactant: 030865
notes: Notes by CellDesigner PMID: 12789259 reaction: direct
fast: false
reversible: false

030877
type: SpeciesReference
stoichiometry: 1.0
species: 299455

030865
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300905
type: Reaction
product: 030411
reactant: 030398
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

030411
type: SpeciesReference
stoichiometry: 1.0
species: 299585

030398
type: SpeciesReference
stoichiometry: 1.0
species: 298923

301190
type: Reaction
product: 033110
reactant: 033098
notes: PMID: 15706352 PMID: 15731768
fast: false
reversible: false

033110
type: SpeciesReference
stoichiometry: 1.0
species: 299748

033098
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300541
type: Reaction
product: 027319
reactant: 027307
notes: PMID: 15175242 PMID: 11034215
fast: false
reversible: false

027319
type: SpeciesReference
stoichiometry: 1.0
species: 299380

027307
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301239
type: Reaction
product: 033566
reactant: 033554
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

033566
type: SpeciesReference
stoichiometry: 1.0
species: 299774

033554
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300952
type: Reaction
product: 030805
reactant: 030793
notes: Notes by CellDesigner PMID: 10766737 PMID: 14576826 reaction: direct
fast: false
reversible: false

030805
type: SpeciesReference
stoichiometry: 1.0
species: 299339

030793
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299872
type: Reaction
product: 020124
reactant: 020112
fast: false
reversible: false

020124
type: SpeciesReference
stoichiometry: 1.0
species: 298863

020112
type: SpeciesReference
stoichiometry: 1.0
species: 298870

300404
type: Reaction
product: 026322
reactant: 026310
notes: PMID: 14990995
fast: false
reversible: false

026322
type: SpeciesReference
stoichiometry: 1.0
species: 299505

026310
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301316
type: Reaction
product: 034262
reactant: 034250
notes: PMID: 16135806
fast: false
reversible: false

034262
type: SpeciesReference
stoichiometry: 1.0
species: 299567

034250
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300218
type: Reaction
modifier: 024314
product: 024302
reactant: 024290
notes: PMID: 15840442 PMID: 11598127
fast: false
reversible: false

024302
type: SpeciesReference
stoichiometry: 1.0
species: 299213

024290
type: SpeciesReference
stoichiometry: 1.0
species: 299215

300388
type: Reaction
product: 026199
reactant: 026187
notes: PMID: 15510213
fast: false
reversible: false

026199
type: SpeciesReference
stoichiometry: 1.0
species: 299427

026187
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300756
type: Reaction
product: 029227
reactant: 029215
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

029227
type: SpeciesReference
stoichiometry: 1.0
species: 299367

029215
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300593
type: Reaction
product: 027799
reactant: 027787
notes: Notes by CellDesigner PMID: 14633988 reaction: direct
fast: false
reversible: false

027799
type: SpeciesReference
stoichiometry: 1.0
species: 299339

027787
type: SpeciesReference
stoichiometry: 1.0
species: 299663

300302
type: Reaction
product: 025335
reactant: 025323
notes: Relocalization of p21 from the nucleus to the cytosol PMID: 16775416 (from REACTOME) PMID: 9632134
fast: false
reversible: false

025335
type: SpeciesReference
stoichiometry: 1.0
species: 299821

025323
type: SpeciesReference
stoichiometry: 1.0
species: 299818

301332
type: Reaction
product: 034445
reactant: 034433
reactant: 034421
notes: p130 binds to and inhibits cyclinA-CDK2, independantly of its phosphorylation state. PMID: 15456871 PMID: 12006580 PMID: 11237530
fast: false
reversible: false

034445
type: SpeciesReference
stoichiometry: 1.0
species: 299832

034433
type: SpeciesReference
stoichiometry: 1.0
species: 298958

034421
type: SpeciesReference
stoichiometry: 1.0
species: 298906

300148
type: Reaction
modifier: 023450
product: 023438
reactant: 023426
notes: Dephosphorylation of CDC2 induces its activation. PMID: 10373560 PMID: 8348613 PMID: 12814430
fast: false
reversible: false

023438
type: SpeciesReference
stoichiometry: 1.0
species: 299164

023426
type: SpeciesReference
stoichiometry: 1.0
species: 299162

299448
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: APAF1

301309
type: Reaction
product: 034190
reactant: 034178
notes: PMID: 16179649
fast: false
reversible: false

034190
type: SpeciesReference
stoichiometry: 1.0
species: 299479

034178
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300654
type: Reaction
product: 028303
reactant: 028291
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

028303
type: SpeciesReference
stoichiometry: 1.0
species: 299650

028291
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300234
type: Reaction
product: 024518
reactant: 024506
notes: Proteolysis degradation via the SCF(SKP2) system. PMID: 10385618 PMID: 12814430 PMID: 12851486 Preliminary phosphorylation and cytoplasm export needed for degradation. PMID: 11355576
fast: false
reversible: false

024518
type: SpeciesReference
stoichiometry: 1.0
species: 299257

024506
type: SpeciesReference
stoichiometry: 1.0
species: 299219

299945
type: Reaction
product: 021025
reversible: false
product: 021037
product: 021001
product: 021049
product: 021013
notes: PMID: 12006580 PMID: 15769944
reactant: 020989
fast: false

021025
type: SpeciesReference
stoichiometry: 1.0
species: 298931

021037
type: SpeciesReference
stoichiometry: 1.0
species: 298908

021001
type: SpeciesReference
stoichiometry: 1.0
species: 298906

021049
type: SpeciesReference
stoichiometry: 1.0
species: 298946

021013
type: SpeciesReference
stoichiometry: 1.0
species: 298807

020989
type: SpeciesReference
stoichiometry: 1.0
species: 298951

300647
type: Reaction
product: 028231
reactant: 028219
notes: Notes by CellDesigner PMID: 15985428
fast: false
reversible: false

028231
type: SpeciesReference
stoichiometry: 1.0
species: 299687

028219
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300395
type: Reaction
product: 026247
reactant: 026235
notes: PMID: 15210709
fast: false
reversible: false

026247
type: SpeciesReference
stoichiometry: 1.0
species: 299507

026235
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301230
type: Reaction
product: 033470
reactant: 033458
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

033470
type: SpeciesReference
stoichiometry: 1.0
species: 299770

033458
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300878
type: Reaction
product: 030139
reactant: 030127
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false

030139
type: SpeciesReference
stoichiometry: 1.0
species: 299658

030127
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300125
type: Reaction
modifier: 023186
product: 023174
reactant: 023162
notes: CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin. PMID: 12814430 WEE1 allows CDC2 to stay in an inactive state after its translocation in late G2 PMID: 10373560 PMID: 8348613 PMID: 9001210 (from REACTOME) PMID: 15037762
fast: false
reversible: false

023174
type: SpeciesReference
stoichiometry: 1.0
species: 299164

023162
type: SpeciesReference
stoichiometry: 1.0
species: 299166

300670
type: Reaction
product: 028447
reactant: 028435
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

028447
type: SpeciesReference
stoichiometry: 1.0
species: 299681

028435
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300663
type: Reaction
product: 028399
reactant: 028387
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

028399
type: SpeciesReference
stoichiometry: 1.0
species: 299369

028387
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300088
type: Reaction
modifier: 022766
product: 022754
reactant: 022742
notes: CDK activity stimulated by its CAK-complex phosphorylation. PMID: 12459251 PMID: 12814430 (ref REACTOME) PMID: 7799941
fast: false
reversible: false

022754
type: SpeciesReference
stoichiometry: 1.0
species: 299168

022742
type: SpeciesReference
stoichiometry: 1.0
species: 299166

301081
type: Reaction
product: 032054
reactant: 032042
notes: Notes by CellDesigner PMID: 16179649
fast: false
reversible: false

032054
type: SpeciesReference
stoichiometry: 1.0
species: 299685

032042
type: SpeciesReference
stoichiometry: 1.0
species: 299311

300801
type: Reaction
product: 029659
reactant: 029647
notes: Notes by CellDesigner PMID: 15574337 reaction: direct
fast: false
reversible: false

029659
type: SpeciesReference
stoichiometry: 1.0
species: 299486

029647
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301300
type: Reaction
product: 034118
reactant: 034106
notes: PMID: 16179649
fast: false
reversible: false

034118
type: SpeciesReference
stoichiometry: 1.0
species: 299479

034106
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300279
type: Reaction
product: 025095
reactant: 025083
reactant: 025071
notes: PMID: 12210082 PMID: 10498883
fast: false
reversible: false

025095
type: SpeciesReference
stoichiometry: 1.0
species: 299300

025083
type: SpeciesReference
stoichiometry: 1.0
species: 298849

025071
type: SpeciesReference
stoichiometry: 1.0
species: 299790

300785
type: Reaction
product: 029515
reactant: 029503
notes: Notes by CellDesigner PMID: 14990995
fast: false
reversible: false

029515
type: SpeciesReference
stoichiometry: 1.0
species: 299505

029503
type: SpeciesReference
stoichiometry: 1.0
species: 299838

299628
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CSTF3

300776
type: Reaction
product: 029419
reactant: 029407
notes: Notes by CellDesigner PMID: 10733529 PMID: 10766737 reaction: direct
fast: false
reversible: false

029419
type: SpeciesReference
stoichiometry: 1.0
species: 299556

029407
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301268
type: Reaction
product: 033806
reactant: 033794
notes: PMID: 16984923
fast: false
reversible: false

033806
type: SpeciesReference
stoichiometry: 1.0
species: 299783

033794
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300918
type: Reaction
product: 030565
reactant: 030553
notes: Notes by CellDesigner PMID: 16144839PMID: 14990995
fast: false
reversible: false

030565
type: SpeciesReference
stoichiometry: 1.0
species: 299505

030553
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300965
type: Reaction
product: 030925
reactant: 030913
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

030925
type: SpeciesReference
stoichiometry: 1.0
species: 299494

030913
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299641
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ECE1C

299997
type: Reaction
product: 021721
reactant: 021709
reactant: 021697
reactant: 021685
notes: PMID: 15536069 PMID: 15470680
fast: false
reversible: false

021721
type: SpeciesReference
stoichiometry: 1.0
species: 299018

021709
type: SpeciesReference
stoichiometry: 1.0
species: 299013

021697
type: SpeciesReference
stoichiometry: 1.0
species: 299000

021685
type: SpeciesReference
stoichiometry: 1.0
species: 299016

299920
type: Reaction
product: 020677
reactant: 020665
notes: relatively low nuclear levels of E2F4 is maintained by efficient CRM1-dependent nuclear export. PMID: 11158323 E2F-5 is exported from the nucleus through leptomycin B-sensitive, CRM1-mediated transport, through a region corresponding to amino acid residues 130-154. PMID: 12089160
fast: false
reversible: false

020677
type: SpeciesReference
stoichiometry: 1.0
species: 298921

020665
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299869
type: Reaction
modifier: 020100
product: 020088
reactant: 020076
notes: E2F1 deacetylated by pRB/HDAC PMID: 15126619 Deacetylation by HDAC1 PMID: 10753885
fast: false
reversible: false

020088
type: SpeciesReference
stoichiometry: 1.0
species: 298870

020076
type: SpeciesReference
stoichiometry: 1.0
species: 298868

300792
type: Reaction
product: 029587
reactant: 029575
notes: Notes by CellDesigner PMID: 10766737 PMID: 14576826 reaction: direct
fast: false
reversible: false

029587
type: SpeciesReference
stoichiometry: 1.0
species: 299339

029575
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300331
type: Reaction
product: 025671
reactant: 025659
notes: PMID: 15897325
fast: false
reversible: false

025671
type: SpeciesReference
stoichiometry: 1.0
species: 299453

025659
type: SpeciesReference
stoichiometry: 1.0
species: 299840

298928
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: a7_degraded

301259
type: Reaction
product: 033710
reactant: 033698
notes: PMID: 16792505
fast: false
reversible: false

033710
type: SpeciesReference
stoichiometry: 1.0
species: 299816

033698
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300177
type: Reaction
product: 023798
reactant: 023786
reactant: 023774
notes: Complex cyclinA-CDK2 inhibited by its interaction with CKI PMID: 10385618
fast: false
reversible: false

023798
type: SpeciesReference
stoichiometry: 1.0
species: 299230

023786
type: SpeciesReference
stoichiometry: 1.0
species: 299088

023774
type: SpeciesReference
stoichiometry: 1.0
species: 298958

300261
type: Reaction
modifier: 024866
product: 024854
reactant: 024842
notes: PMID: 15829956 PMID: 15140942 Auto-phosphorylation catalysed by E2F1 PMID: 15024084 (ref REACTOME) PMID: 12556884 Autophosphorylation of ATM within dimeric ATM complexes
fast: false
reversible: false

024854
type: SpeciesReference
stoichiometry: 1.0
species: 298847

024842
type: SpeciesReference
stoichiometry: 1.0
species: 299275

300063
type: Reaction
product: 022477
reactant: 022465
reactant: 022452
notes: PMID: 10385618 PMID: 10498883 (ref REACTOME) PMID: 9106657
fast: false
reversible: false

022477
type: SpeciesReference
stoichiometry: 1.0
species: 299117

022465
type: SpeciesReference
stoichiometry: 1.0
species: 299075

022452
type: SpeciesReference
stoichiometry: 1.0
species: 299054

300182
type: Reaction
product: 023870
product: 023858
reactant: 023846
notes: PMID: 8861947
fast: false
reversible: false

023870
type: SpeciesReference
stoichiometry: 1.0
species: 299200

023858
type: SpeciesReference
stoichiometry: 1.0
species: 299207

023846
type: SpeciesReference
stoichiometry: 1.0
species: 299226

300739
type: Reaction
product: 029095
reactant: 029083
notes: Notes by CellDesigner PMID: 15510213 reaction: direct
fast: false
reversible: false

029095
type: SpeciesReference
stoichiometry: 1.0
species: 299378

029083
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300744
type: Reaction
modifier: 029155
product: 029143
reactant: 029131
notes: PMID: 10766737 PMID: 16135806
fast: false
reversible: false

029143
type: SpeciesReference
stoichiometry: 1.0
species: 299812

029131
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300737
type: Reaction
product: 029071
reactant: 029059
notes: Notes by CellDesigner PMID: 11883935
fast: false
reversible: false

029071
type: SpeciesReference
stoichiometry: 1.0
species: 299380

029059
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300485
type: Reaction
product: 026887
reactant: 026875
notes: PMID: 14990995
fast: false
reversible: false

026887
type: SpeciesReference
stoichiometry: 1.0
species: 299410

026875
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300031
type: Reaction
product: 022170
reactant: 022158
reactant: 022146
notes: The complex cyclinD-CDK stability increases when bound to a Cip/Kip family member. PMID: 10385618
fast: false
reversible: false

022170
type: SpeciesReference
stoichiometry: 1.0
species: 299095

022158
type: SpeciesReference
stoichiometry: 1.0
species: 299097

022146
type: SpeciesReference
stoichiometry: 1.0
species: 299088

301320
type: Reaction
product: 034310
reactant: 034298
notes: PMID: 10733529 PMID: 15014447
fast: false
reversible: false

034310
type: SpeciesReference
stoichiometry: 1.0
species: 299667

034298
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301313
type: Reaction
product: 034238
reactant: 034226
fast: false
reversible: false

034238
type: SpeciesReference
stoichiometry: 1.0
species: 299674

034226
type: SpeciesReference
stoichiometry: 1.0
species: 298923

301166
type: Reaction
product: 032870
reactant: 032858
notes: PMID: 11564866
fast: false
reversible: false

032870
type: SpeciesReference
stoichiometry: 1.0
species: 299726

032858
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301159
type: Reaction
product: 032798
reactant: 032786
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false

032798
type: SpeciesReference
stoichiometry: 1.0
species: 299720

299720
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SLC25A14

032786
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300383
type: Reaction
product: 026151
reactant: 026139
notes: PMID: 12611887
fast: false
reversible: false

026151
type: SpeciesReference
stoichiometry: 1.0
species: 299430

026139
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300206
type: Reaction
modifier: 024170
product: 024158
reactant: 024146
notes: CDK activity activated by its phosphorylation by CAK-complex PMID: 11959850
fast: false
reversible: false

024158
type: SpeciesReference
stoichiometry: 1.0
species: 298886

024146
type: SpeciesReference
stoichiometry: 1.0
species: 298958

300376
type: Reaction
product: 026079
reactant: 026067
notes: PMID: 12909625
fast: false
reversible: false

026079
type: SpeciesReference
stoichiometry: 1.0
species: 299435

026067
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300381
type: Reaction
product: 026127
reactant: 026115
notes: PMID: 15510213
fast: false
reversible: false

026127
type: SpeciesReference
stoichiometry: 1.0
species: 299559

026115
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300145
type: Reaction
modifier: 023414
product: 023402
reactant: 023390
notes: Dephosphorylation of CDC2 induces its activation. PMID: 10373560 PMID: 8348613 PMID: 12814430
fast: false
reversible: false

023402
type: SpeciesReference
stoichiometry: 1.0
species: 299180

023390
type: SpeciesReference
stoichiometry: 1.0
species: 299177

301057
type: Reaction
product: 031813
reactant: 031801
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false

031813
type: SpeciesReference
stoichiometry: 1.0
species: 299371

031801
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300437
type: Reaction
product: 026623
reactant: 026611
notes: PMID: 15014447
fast: false
reversible: false

026623
type: SpeciesReference
stoichiometry: 1.0
species: 299350

026611
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300651
type: Reaction
product: 028279
reactant: 028267
notes: Notes by CellDesigner PMID: 12004135 reaction: direct
fast: false
reversible: false

028279
type: SpeciesReference
stoichiometry: 1.0
species: 299483

028267
type: SpeciesReference
stoichiometry: 1.0
species: 299313

300008
type: Reaction
product: 021877
reactant: 021865
reactant: 021853
notes: sequestration of CDK6 to prevent its association with Cyclins D and RB phosphorylation PMID: 11960696 (ref REACTOME) PMID: 8078588 PMID: 8741839 PMID: 8001816 PMID: 8259215
fast: false
reversible: false

021877
type: SpeciesReference
stoichiometry: 1.0
species: 299065

021865
type: SpeciesReference
stoichiometry: 1.0
species: 299051

021853
type: SpeciesReference
stoichiometry: 1.0
species: 299044

299933
type: Reaction
product: 020845
reactant: 020833
reactant: 020821
fast: false
reversible: false

020845
type: SpeciesReference
stoichiometry: 1.0
species: 298939

020833
type: SpeciesReference
stoichiometry: 1.0
species: 298903

020821
type: SpeciesReference
stoichiometry: 1.0
species: 298942

299805
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p18INK4c*

300994
type: Reaction
product: 031213
reactant: 031201
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false

031213
type: SpeciesReference
stoichiometry: 1.0
species: 299360

031201
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300581
type: Reaction
product: 027703
reactant: 027691
notes: PMID: 15897325
fast: false
reversible: false

027703
type: SpeciesReference
stoichiometry: 1.0
species: 299652

027691
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301141
type: Reaction
product: 032630
reactant: 032618
notes: PMID: 10733529 PMID: 14688249 PMID: 15574595
fast: false
reversible: false

032630
type: SpeciesReference
stoichiometry: 1.0
species: 299681

032618
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300866
type: Reaction
product: 030043
reactant: 030031
notes: PMID: 10766737
fast: false
reversible: false

030043
type: SpeciesReference
stoichiometry: 1.0
species: 299812

030031
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300707
type: Reaction
product: 028807
reactant: 028795
notes: Notes by CellDesigner PMID: 14597855 reaction: direct
fast: false
reversible: false

028807
type: SpeciesReference
stoichiometry: 1.0
species: 299641

028795
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300705
type: Reaction
product: 028783
reactant: 028771
notes: Notes by CellDesigner PMID: 12566389 reaction: direct
fast: false
reversible: false

028783
type: SpeciesReference
stoichiometry: 1.0
species: 299583

028771
type: SpeciesReference
stoichiometry: 1.0
species: 299843

299928
type: Reaction
product: 020773
reactant: 020761
notes: Degradation via the ubiquitin-proteasome system. PMID: 10773440 Degradation via SCF(SKP2) (=SKP1-Culin1-SKP2) PMID: 12717421
fast: false
reversible: false

020773
type: SpeciesReference
stoichiometry: 1.0
species: 298928

020761
type: SpeciesReference
stoichiometry: 1.0
species: 298906

300258
type: Reaction
modifier: 024830
modifier: 024818
product: 024806
reactant: 024794
notes: PMID: 15024084 PMID: 15140942
fast: false
reversible: false

024806
type: SpeciesReference
stoichiometry: 1.0
species: 299287

024794
type: SpeciesReference
stoichiometry: 1.0
species: 299284

300076
type: Reaction
product: 022645
reactant: 022633
reactant: 022621
notes: PMID: 16775416
fast: false
reversible: false

022645
type: SpeciesReference
stoichiometry: 1.0
species: 298967

022633
type: SpeciesReference
stoichiometry: 1.0
species: 299091

022621
type: SpeciesReference
stoichiometry: 1.0
species: 299825

301288
type: Reaction
product: 033998
reactant: 033986
notes: PMID: 12368233
fast: false
reversible: false

033998
type: SpeciesReference
stoichiometry: 1.0
species: 299810

033986
type: SpeciesReference
stoichiometry: 1.0
species: 299838

300712
type: Reaction
product: 028855
reactant: 028843
notes: Notes by CellDesigner PMID: 14532106
fast: false
reversible: false

028855
type: SpeciesReference
stoichiometry: 1.0
species: 299412

028843
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300938
type: Reaction
product: 030685
reactant: 030673
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false

030685
type: SpeciesReference
stoichiometry: 1.0
species: 299628

030673
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300882
type: Reaction
product: 030187
reactant: 030175
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false

030187
type: SpeciesReference
stoichiometry: 1.0
species: 299637

030175
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300335
type: Reaction
product: 025719
reactant: 025707
notes: PMID: 12149244
fast: false
reversible: false

025719
type: SpeciesReference
stoichiometry: 1.0
species: 299448

025707
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300936
type: Reaction
product: 030661
reactant: 030649
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false

030661
type: SpeciesReference
stoichiometry: 1.0
species: 299630

030649
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300985
type: Reaction
product: 031117
reactant: 031105
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

031117
type: SpeciesReference
stoichiometry: 1.0
species: 299362

031105
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300421
type: Reaction
product: 026476
reactant: 026463
notes: PMID: 10998368
fast: false
reversible: false

026476
type: SpeciesReference
stoichiometry: 1.0
species: 299600

026463
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300859
type: Reaction
product: 029971
reactant: 029959
notes: Notes by CellDesigner PMID: 15014447 reaction: direct
fast: false
reversible: false

029971
type: SpeciesReference
stoichiometry: 1.0
species: 299481

029959
type: SpeciesReference
stoichiometry: 1.0
species: 299838

301349
type: Reaction
product: 034645
reactant: 034632
fast: false
reversible: false

034645
type: SpeciesReference
stoichiometry: 1.0
species: 299313

034632
type: SpeciesReference
stoichiometry: 1.0
species: 299475

300696
type: Reaction
product: 028687
reactant: 028675
notes: Notes by CellDesigner PMID: 14990995 reaction: direct
fast: false
reversible: false

028687
type: SpeciesReference
stoichiometry: 1.0
species: 299505

028675
type: SpeciesReference
stoichiometry: 1.0
species: 299843

300104
type: Reaction
modifier: 022970
product: 022958
reactant: 022946
notes: Phosphorylation only when CDC2 is bound to the cyclin D. PMID: 10373560 PMID: 9001210 PMID: 12814430
fast: false
reversible: false

022958
type: SpeciesReference
stoichiometry: 1.0
species: 299177

022946
type: SpeciesReference
stoichiometry: 1.0
species: 299175

301293
type: Reaction
product: 034046
reactant: 034034
notes: PMID: 12368233
fast: false
reversible: false

034046
type: SpeciesReference
stoichiometry: 1.0
species: 299810

034034
type: SpeciesReference
stoichiometry: 1.0
species: 299309

300274
type: Reaction
modifier: 025022
product: 025010
reactant: 024998
notes: PMID: 12814430 (ref REACTOME) PMID: 12861053
fast: false
reversible: false

025010
type: SpeciesReference
stoichiometry: 1.0
species: 299280

024998
type: SpeciesReference
stoichiometry: 1.0
species: 299278

299903
type: Reaction
product: 020484
reactant: 020472
reactant: 020460
notes: PMID: 10964686
fast: false
reversible: false

020484
type: SpeciesReference
stoichiometry: 1.0
species: 298935

020472
type: SpeciesReference
stoichiometry: 1.0
species: 298931

020460
type: SpeciesReference
stoichiometry: 1.0
species: 298807

300687
type: Reaction
product: 028615
reactant: 028603
notes: Notes by CellDesigner PMID: 15510213 reaction: direct
fast: false
reversible: false

028615
type: SpeciesReference
stoichiometry: 1.0
species: 299427

028603
type: SpeciesReference
stoichiometry: 1.0
species: 299843

301179
type: Reaction
product: 032990
reactant: 032978
notes: PMID: 12446714
fast: false
reversible: false

032990
type: SpeciesReference
stoichiometry: 1.0
species: 299741

032978
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301040
type: Reaction
product: 031669
reactant: 031657
notes: Notes by CellDesigner PMID: 16135806 reaction: directPMID: 15574595
fast: false
reversible: false

031669
type: SpeciesReference
stoichiometry: 1.0
species: 299527

031657
type: SpeciesReference
stoichiometry: 1.0
species: 298923

299801
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p57KIP2*

301263
type: Reaction
product: 033758
reactant: 033746
notes: PMID: 16984923
fast: false
reversible: false

033758
type: SpeciesReference
stoichiometry: 1.0
species: 299783

033746
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301186
type: Reaction
product: 033062
reactant: 033050
notes: PMID: 15706352
fast: false
reversible: false

033062
type: SpeciesReference
stoichiometry: 1.0
species: 299745

033050
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300911
type: Reaction
product: 030489
reactant: 030476
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false

030489
type: SpeciesReference
stoichiometry: 1.0
species: 299364

030476
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300328
type: Reaction
product: 025647
reactant: 025635
notes: PMID: 9819415
fast: false
reversible: false

025647
type: SpeciesReference
stoichiometry: 1.0
species: 299330

025635
type: SpeciesReference
stoichiometry: 1.0
species: 299298

301184
type: Reaction
product: 033038
reactant: 033026
notes: PMID: 15897325
fast: false
reversible: false

033038
type: SpeciesReference
stoichiometry: 1.0
species: 299743

033026
type: SpeciesReference
stoichiometry: 1.0
species: 299840

301003
type: Reaction
product: 031309
reactant: 031297
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false

031309
type: SpeciesReference
stoichiometry: 1.0
species: 299543

031297
type: SpeciesReference
stoichiometry: 1.0
species: 298923

300489
type: Reaction
product: 026935
reactant: 026923
notes: PMID: 14684737
fast: false
reversible: false

026935
type: SpeciesReference
stoichiometry: 1.0
species: 299466

026923
type: SpeciesReference
stoichiometry: 1.0
species: 299840

300037
type: Reaction
modifier: 022244
product: 022232
reactant: 022220
notes: PMID: 12459251 PMID: 10385618 (ref REACTOME) PMID: 16732330
fast: false
reversible: false

022232
type: SpeciesReference
stoichiometry: 1.0
species: 299104

022220
type: SpeciesReference
stoichiometry: 1.0
species: 299097

300028
type: Reaction
modifier: 022133
modifier: 022121
product: 022109
reactant: 022097
notes: All three Cip/Kip family members direct the accumulation of cylinD-CDK complexes in the nucleus. PMID: 10385618
fast: false
reversible: false

022109
type: SpeciesReference
stoichiometry: 1.0
species: 299091

022097
type: SpeciesReference
stoichiometry: 1.0
species: 299119

299864
type: Reaction
product: 020028
product: 020016
product: 020004
reactant: 019992
notes: PMID: 15840440 PMID: 15133492
fast: false
reversible: false

020028
type: SpeciesReference
stoichiometry: 1.0
species: 298824

020016
type: SpeciesReference
stoichiometry: 1.0
species: 298868

020004
type: SpeciesReference
stoichiometry: 1.0
species: 298857

019992
type: SpeciesReference
stoichiometry: 1.0
species: 298892