MODEL2463576061
type: SBMLModel
species: 304740
species: 305046
species: 304694
reaction: 306394
species: 305587
species: 304562
species: 305678
species: 304572
species: 305546
species: 304521
reaction: 306267
reaction: 306169
species: 305015
species: 304918
species: 304815
reaction: 306348
reaction: 305987
species: 305595
species: 305647
species: 305708
species: 304900
species: 305680
species: 305515
species: 304667
species: 305270
reaction: 305793
reaction: 305802
reaction: 305949
species: 305645
species: 305326
species: 305223
reaction: 306276
species: 305411
reaction: 306420
species: 305239
species: 305040
reaction: 306144
species: 305723
species: 305085
species: 305107
species: 305581
species: 305056
reaction: 306231
species: 304976
reaction: 306236
reaction: 306138
reaction: 305928
species: 305054
area units: area
species: 305169
reaction: 306140
species: 305370
species: 304616
species: 304599
reaction: 306391
reaction: 306221
reaction: 306123
reaction: 306293
species: 304861
species: 305452
species: 305132
species: 305401
reaction: 305977
species: 305177
reaction: 305822
species: 305384
species: 304908
species: 304527
species: 305637
reaction: 306096
species: 305608
species: 304602
reaction: 306432
species: 304925
species: 304589
species: 305335
species: 304593
reaction: 305748
reaction: 305784

304740
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Eps8_br_@EGFR./active_br_RN-tre)

304479
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0

305046
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: target genes_br_transcription

304694
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: GDP

306394
type: Reaction
modifier: 641457
modifier: 641445
product: 641433
reactant: 641421
notes: active EGFR: PMID: 8378775 PMID: 9287210 active c-Src: PMID: 10358079
fast: false
reversible: false

304532
type: Species
notes: PMID: 9667855 PMID: 9779993
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(ErbB1_br_ligand/active_br_EGFR)

304677
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active c-Src_br_@Pyk2.Y402P

641433
type: SpeciesReference
stoichiometry: 1.0
species: 305634

305634
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: STAT1

641421
type: SpeciesReference
stoichiometry: 1.0
species: 305620

305620
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: STAT1

305587
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: CaMK

304562
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: KDI1

305678
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_ERK1

304572
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: SOS1

305546
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: p21

304521
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: ErbB1_br_ligand

306267
type: Reaction
product: 639897
reactant: 639885
fast: false
reversible: false

639897
type: SpeciesReference
stoichiometry: 1.0
species: 305354

305354
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: p15

639885
type: SpeciesReference
stoichiometry: 1.0
species: 305067

305067
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: m.p15

306169
type: Reaction
product: 638226
fast: false
notes: active LARG: PMID: 12771155
reversible: false
product: 638214
reactant: 638202
reactant: 638190
modifier: 638238

638226
type: SpeciesReference
stoichiometry: 1.0
species: 304694

638214
type: SpeciesReference
stoichiometry: 1.0
species: 305184

305184
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GTP/RhoA)

638202
type: SpeciesReference
stoichiometry: 1.0
species: 304705

304705
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: GTP

638190
type: SpeciesReference
stoichiometry: 1.0
species: 305186

305186
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/RhoA)

305196
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_LARG

305015
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-fos

304918
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MKK7

304815
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304503
name: late end._br_EGFR

304503
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: late_br_endsome

306348
type: Reaction
modifier: 640869
product: 640856
reactant: 640844
notes: CAK: PMID: 8139570
fast: false
reversible: false

305469
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: CAK

640856
type: SpeciesReference
stoichiometry: 1.0
species: 305556

305556
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Cyclin D/Cdk4/6)

640844
type: SpeciesReference
stoichiometry: 1.0
species: 305553

305553
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Cdk4/6/Cyclin D)

305987
type: Reaction
product: 635969
reactant: 635957
notes: PMID: 12706116 PMID: 11546808
fast: false
reversible: false

635969
type: SpeciesReference
stoichiometry: 1.0
species: 305684

305684
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: nuc.ERK1

635957
type: SpeciesReference
stoichiometry: 1.0
species: 305680

305680
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_ERK1

305595
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(CaM/cyt._br_Ca_super_2+/CaMK)

305647
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Cyclin E/Cdk2)

305708
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_RSK2

304900
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_MKK6

305515
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Gab1_br_@EGFR.

304667
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_Pyk2

305270
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(LPA/active_br_LPA_sub_1)

305793
type: Reaction
modifier: 633624
modifier: 633612
product: 633600
reactant: 633588
notes: Gab1: PMID: 11943184 PMID: 10648629 PMID: 15550174 Gab1@EGFR.Y1068/1086P: PMID: 10648629
fast: false
reversible: false

304619
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Grb2_br_@EGFR._br_Y1068/1086P/Gab1)

633600
type: SpeciesReference
stoichiometry: 1.0
species: 304632

304632
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(PI3K(p85)_br_@Gab1._br_Y446/472/589P/active_br_PI3K(p110))

633588
type: SpeciesReference
stoichiometry: 1.0
species: 304629

304629
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(PI3K(p110)/PI3K(p85))

305802
type: Reaction
product: 633732
reactant: 633720
reactant: 633708
notes: PMID: 8695788 PMID: 10704819
fast: false
reversible: false

633732
type: SpeciesReference
stoichiometry: 1.0
species: 304664

304664
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Grb2_br_@EGFR._br_Y1068/1086P/Pyk2)

633720
type: SpeciesReference
stoichiometry: 1.0
species: 304647

304647
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Pyk2

633708
type: SpeciesReference
stoichiometry: 1.0
species: 304569

304569
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Grb2_br_@EGFR._br_Y1068/1086P

305949
type: Reaction
modifier: 635477
product: 635465
reactant: 635453
notes: MKL3@GTP+Rac1/Cdc42: PMID: 9003778
fast: false
reversible: false

304868
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MLK3_br_@Rac1 or Cdc42

635465
type: SpeciesReference
stoichiometry: 1.0
species: 304895

304895
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_MKK3

635453
type: SpeciesReference
stoichiometry: 1.0
species: 304892

304892
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MKK3

305645
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Cdk2

305326
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/G_alpha_ _sub_12/13)

305223
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_adenylyl_br_cyclase II

306276
type: Reaction
product: 639993
reactant: 639981
reactant: 639969
notes: PMID: 11875501
fast: false
reversible: false

639993
type: SpeciesReference
stoichiometry: 1.0
species: 305370

305370
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(PGE_sub_2/active_br_EP2/4)

639981
type: SpeciesReference
stoichiometry: 1.0
species: 305361

305361
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: EP2/4

639969
type: SpeciesReference
stoichiometry: 1.0
species: 305364

305364
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PGE_sub_2

305411
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Chk

304512
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0

306420
type: Reaction
modifier: 641745
product: 641733
reactant: 641721
notes: active PKB/Akt: PMID: 11023813 PMID: 14663478 PMID: 10576742 PMID: 11443134
fast: false
reversible: false

305608
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_PKB/Akt

641733
type: SpeciesReference
stoichiometry: 1.0
species: 305668

305668
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: pl.m.Raf-1

641721
type: SpeciesReference
stoichiometry: 1.0
species: 305662

305662
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: pl.m.Raf-1

305239
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: ?

305040
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: nuc.c-Fos

306144
type: Reaction
fast: false
product: 637853
notes: active PKA: PMID: 12790797 PMID: 9488697 PMID: 11694504 PMID: 15709678 Ca+CaM+CaMKII: PMID: 12790797 PMID: 15709678 FKBP: 15709678 cADPR: PMID: 12475791 PMID: 9013543
reversible: false
reactant: 637829
modifier: 637877
product: 637841
reactant: 637817
modifier: 637865

637853
type: SpeciesReference
stoichiometry: 1.0
species: 305525

305525
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304509
name: RYR

304509
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: ER

637829
type: SpeciesReference
stoichiometry: 1.0
species: 305145

305145
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: cADPR

305126
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_PKA

637841
type: SpeciesReference
stoichiometry: 1.0
species: 305147

305147
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304509
name: Complex(cADPR/FKBP)

637817
type: SpeciesReference
stoichiometry: 1.0
species: 305528

305528
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304509
name: Complex(RYR/FKBP)

305590
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(CaM/cyt._br_Ca_super_2+/CaMK)

305723
type: Species
notes: ligand: PMID: 10880430 PMID: 11252954 PMID: 10214951
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Complex(NRG-1 biregulin_br_NRG-2 / heregulin/active_br_ErbB3)

305085
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PI4-P

305107
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: DAG

305581
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: p27

305056
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-Myc

306231
type: Reaction
modifier: 639416
product: 639404
product: 639392
reactant: 639380
notes: Galpha: PMID: 7834744 PMID: 11941304
fast: false
reversible: false

305322
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GTP/G_alpha_ _sub_12/13)

639404
type: SpeciesReference
stoichiometry: 1.0
species: 304713

304713
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Pi

639392
type: SpeciesReference
stoichiometry: 1.0
species: 305326

639380
type: SpeciesReference
stoichiometry: 1.0
species: 305322

304976
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-Jun

306236
type: Reaction
product: 639452
reactant: 639440
reactant: 639428
notes: PMID: 7834744 PMID: 11941304 PMID: 12354102
fast: false
reversible: false

639452
type: SpeciesReference
stoichiometry: 1.0
species: 305289

305289
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/G_alpha_ _sub_q/G_beta/G_gamma)

639440
type: SpeciesReference
stoichiometry: 1.0
species: 305277

305277
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(G_beta/G_gamma)

639428
type: SpeciesReference
stoichiometry: 1.0
species: 305297

305297
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/G_alpha_ _sub_q)

306138
type: Reaction
modifier: 637769
product: 637757
reactant: 637745
notes: SERCA: PMID: 9202841 PMID: 7929371
fast: false
reversible: false

305141
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304509
name: SERCA

637757
type: SpeciesReference
stoichiometry: 1.0
species: 305135

305135
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304509
name: ER._br_Ca_super_2+

637745
type: SpeciesReference
stoichiometry: 1.0
species: 305132

305132
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: cyt._br_Ca_super_2+

305928
type: Reaction
modifier: 635249
modifier: 635237
product: 635225
reactant: 635213
notes: active PKB/Akt: PMID: 9346240 PMID: 12829245 PMID: 15209377 PAK1@GTP+Rac/Cdc42: PMID: 11950587 PMID: 10611223
fast: false
reversible: false

304842
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Grb2_br_@EGFR._br_Y1068/1086P/PAK1_br_@GTP-Rac_br_or Cdc42)

635225
type: SpeciesReference
stoichiometry: 1.0
species: 304853

304853
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Bad

635213
type: SpeciesReference
stoichiometry: 1.0
species: 304850

304850
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Bad

305054
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-Myc

305169
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: choline

306140
type: Reaction
modifier: 637805
product: 637793
reactant: 637781
notes: Ca+CaM+CaMKII: PMID: 15709678 PMID: 7929371
fast: false
reversible: false

637793
type: SpeciesReference
stoichiometry: 1.0
species: 305141

637781
type: SpeciesReference
stoichiometry: 1.0
species: 305139

305139
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304509
name: SERCA

304616
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Gab1

304599
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: SHP2_br_@EGFR.

306391
type: Reaction
product: 641409
reactant: 641397
reactant: 641385
notes: PMID: 7626805 PMID: 10439039 PMID: 12459251 PMID: 7758941
fast: false
reversible: false

641409
type: SpeciesReference
stoichiometry: 1.0
species: 305559

305559
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(p21/Cyclin D/Cdk4/6)

641397
type: SpeciesReference
stoichiometry: 1.0
species: 305546

641385
type: SpeciesReference
stoichiometry: 1.0
species: 305553

306221
type: Reaction
reactant: 639188
notes: RGS4: PMID: 14607243 PMID: 11356902 RGS7: PMID: 14607243 PMID: 11356902 PMID: 10862767 Galpha: PMID: 7834744 PMID: 11941304 PMID: 12354102
product: 639200
modifier: 639248
product: 639212
reversible: false
modifier: 639236
fast: false
modifier: 639224

639188
type: SpeciesReference
stoichiometry: 1.0
species: 305285

305285
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GTP/G_alpha_ _sub_i)

639200
type: SpeciesReference
stoichiometry: 1.0
species: 305283

305283
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/G_alpha_ _sub_i)

305346
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(CaM/cyt._br_Ca_super_2+/active_br_RGS4)

639212
type: SpeciesReference
stoichiometry: 1.0
species: 304713

305335
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: RGS7

306123
type: Reaction
modifier: 637589
product: 637577
reactant: 637565
notes: phosphatidic acid: PMID: 1313792 PMID: 12790797
fast: false
reversible: false

305521
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: phosphatidic_br_acid

637577
type: SpeciesReference
stoichiometry: 1.0
species: 305117

305117
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_PI5K

637565
type: SpeciesReference
stoichiometry: 1.0
species: 305114

305114
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PI5K

306293
type: Reaction
product: 640219
reactant: 640206
notes: HB-EGF: PMID: 10622253 PMID: 11252954
fast: false
reversible: false

640219
type: SpeciesReference
stoichiometry: 1.0
species: 304521

640206
type: SpeciesReference
stoichiometry: 1.0
species: 305404

305404
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: HB-EGF

304861
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MLK3

305452
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: cyclin D

305401
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: pro HB-EGF

305977
type: Reaction
modifier: 635873
modifier: 635861
product: 635849
reactant: 635837
notes: pl.m.Raf-1: PMID: 11023813 PMID: 1322500 PMID: 1326789 PMID: 8393135 MEKK1@GTP+Rac1/Cdc42: PMID: 8385802 PMID: 7624324
fast: false
reversible: false

304871
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MEKK1_br_@GTP-Rac1_br_or -Cdc42

635849
type: SpeciesReference
stoichiometry: 1.0
species: 304942

304942
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_MKK2

635837
type: SpeciesReference
stoichiometry: 1.0
species: 304935

304935
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MKK2

305177
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_PLD

305822
type: Reaction
product: 633996
reactant: 633984
reactant: 633972
notes: PMID: 12522133
fast: false
reversible: false

633996
type: SpeciesReference
stoichiometry: 1.0
species: 304690

304690
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Grb2_br_@EGFR._br_Y1068/1086P/PAK1)

633984
type: SpeciesReference
stoichiometry: 1.0
species: 304687

304687
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PAK1

633972
type: SpeciesReference
stoichiometry: 1.0
species: 304569

305384
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(S1P/active_br_S1P_sub_1)

304908
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_p38MAPK

304527
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(ErbB1_br_ligand/active_br_EGFR)

305637
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: nuc.STAT3

306096
type: Reaction
modifier: 637229
product: 637217
reactant: 637205
notes: active PI5K: PMID: 15276015 PMID: 11395417 PMID: 10358929
fast: false
reversible: false

637217
type: SpeciesReference
stoichiometry: 1.0
species: 305082

305082
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PI4,5-P_sub_2

637205
type: SpeciesReference
stoichiometry: 1.0
species: 305085

304602
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Eps8

306432
type: Reaction
modifier: 641901
product: 641889
reactant: 641877
notes: active PDK1: PMID: 10411321
fast: false
reversible: false

305702
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_PDK1

641889
type: SpeciesReference
stoichiometry: 1.0
species: 305699

305699
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: RSK2

641877
type: SpeciesReference
stoichiometry: 1.0
species: 305690

305690
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: RSK

304925
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: JNK

304589
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479

304593
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: SHP2

305748
type: Reaction
modifier: 633047
product: 633035
reactant: 633023
notes: active EGFR: PMID: 12006650 PMID: 11084343 PMID: 7518560 PMID: 7527043
fast: false
reversible: false

633035
type: SpeciesReference
stoichiometry: 1.0
species: 304569

633023
type: SpeciesReference
stoichiometry: 1.0
species: 304565

304565
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Grb2

305784
type: Reaction
modifier: 633491
product: 633479
reactant: 633467
notes: SHP2@EGFR: PMID: 12024020 PMID: 15550174
fast: false
reversible: false

633479
type: SpeciesReference
stoichiometry: 1.0
species: 304616

633467
type: SpeciesReference
stoichiometry: 1.0
species: 305515

305229
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_PLC_beta

305538
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Rb/E2F)

304730
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_Rin1@GTP-Ras

305293
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GTP/G_alpha_ _sub_q)

306324
type: Reaction
product: 640568
reactant: 640556
notes: PMID: 9990038
fast: false
reversible: false

640568
type: SpeciesReference
stoichiometry: 1.0
species: 305446

305446
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: tumorigenesis

640556
type: SpeciesReference
stoichiometry: 1.0
species: 304682

304682
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(ErbB1_br_ligand/active_br_EGFR)

305623
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_STAT1

305865
type: Reaction
modifier: 634598
product: 634586
reactant: 634574
notes: active PKC: PMID: 10816576
fast: false
reversible: false

304762
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_PKC

634586
type: SpeciesReference
stoichiometry: 1.0
species: 304774

304774
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304490
name: early end._br_EGFR

304490
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: early_br_endsome

634574
type: SpeciesReference
stoichiometry: 1.0
species: 304771

304771
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304490
name: early end._br_EGFR

306307
type: Reaction
modifier: 640412
product: 640400
reactant: 640388
notes: active ErbB3: PMID: 8026468
fast: false
reversible: false

640400
type: SpeciesReference
stoichiometry: 1.0
species: 305433

305433
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Shc_br_@ErbB3_br_Y1309P

640388
type: SpeciesReference
stoichiometry: 1.0
species: 305481

305481
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Shc

304807
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: a178_degraded

304643
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PLC_gamma__br_@EGFR._br_Y992/1173P

306441
type: Reaction
product: 641961
reactant: 641949
fast: false
reversible: false

641961
type: SpeciesReference
stoichiometry: 1.0
species: 304847

304847
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: actin_br_reorganization

641949
type: SpeciesReference
stoichiometry: 1.0
species: 305132

305959
type: Reaction
reversible: false
modifier: 635609
product: 635597
modifier: 635633
modifier: 635621
reactant: 635585
fast: false
notes: MEKK4@GTP+Rac1+Cdc42: PMID: 15731347 MEKK1@GTP+Rac1/Cdc42: PMID: 12456688 PMID: 9582321 MLK3@GTP+Rac1/Cdc42: PMID: 9003778

304887
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MEKK4_br_@GTP-Rac1_br_-Cdc42

635597
type: SpeciesReference
stoichiometry: 1.0
species: 304914

304914
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_MKK4

635585
type: SpeciesReference
stoichiometry: 1.0
species: 304910

304910
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MKK4

306343
type: Reaction
modifier: 640808
product: 640796
reactant: 640784
reactant: 640772
notes: binding: PMID: 8302605 PMID: 12459251 PMID: 8513492 p15: PMID: 8078588 PMID: 7624138 PMID: 7758941
fast: false
reversible: false

640796
type: SpeciesReference
stoichiometry: 1.0
species: 305553

640784
type: SpeciesReference
stoichiometry: 1.0
species: 305549

305549
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Cdk4/6

640772
type: SpeciesReference
stoichiometry: 1.0
species: 305464

305464
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Cyclin D

306135
type: Reaction
modifier: 637733
modifier: 637721
product: 637709
reactant: 637697
notes: IP3R: PMID: 12167631 PMID: 9488697 RYR: PMID: 15709678 PMID: 12475791
fast: false
reversible: false

305122
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304509
name: IP_sub_3_endsub_R

637709
type: SpeciesReference
stoichiometry: 1.0
species: 305132

637697
type: SpeciesReference
stoichiometry: 1.0
species: 305135

305672
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: unidentified_br_S/T kinase(s)

305246
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(active_br_calpain/cyt._br_Ca_super_2+)

305368
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(PGE_sub_2/active_br_EP3)

305925
type: Reaction
product: 635201
reactant: 635189
fast: false
reversible: false

635201
type: SpeciesReference
stoichiometry: 1.0
species: 304847

635189
type: SpeciesReference
stoichiometry: 1.0
species: 305599

305599
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_LIMK1

305774
type: Reaction
modifier: 633371
product: 633359
reactant: 633347
notes: active EGFR: PMID: 14560030
fast: false
reversible: false

633359
type: SpeciesReference
stoichiometry: 1.0
species: 305494

305494
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: RasGAP_br_@EGFR.

633347
type: SpeciesReference
stoichiometry: 1.0
species: 304613

304613
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: RasGAP

305308
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GTP/G_alpha_ _sub_s)

306060
type: Reaction
product: 636809
reactant: 636797
fast: false
reversible: false

636809
type: SpeciesReference
stoichiometry: 1.0
species: 305040

636797
type: SpeciesReference
stoichiometry: 1.0
species: 305033

305033
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-Fos

305479
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Grb2

305498
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Vav2_br_@EGFR.

305944
type: Reaction
product: 635405
reactant: 635393
notes: PMID: 12456688 PMID: 12049732
fast: false
reversible: false

635405
type: SpeciesReference
stoichiometry: 1.0
species: 304882

304882
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: a215_degraded

635393
type: SpeciesReference
stoichiometry: 1.0
species: 304879

304879
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MEKK1_br_@GTP-Rac1_br_or -Cdc42

306120
type: Reaction
modifier: 637529
reversible: false
product: 637517
notes: active PLCbeta: PMID: 12790797 active truncated PLCbeta: PMID: 12790797 PLCgamma: PMID: 10579907
reactant: 637493
fast: false
product: 637505
modifier: 637541
modifier: 637553

637517
type: SpeciesReference
stoichiometry: 1.0
species: 305110

305110
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: IP3

637493
type: SpeciesReference
stoichiometry: 1.0
species: 305082

637505
type: SpeciesReference
stoichiometry: 1.0
species: 305107

305236
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_truncated_br_PLC_beta

304954
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Shc_br_@EGFR._br_Y1148/1173P/Grb2/SOS1)

305077
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PI3,4,5-P_sub_3

306278
type: Reaction
product: 640029
reactant: 640017
reactant: 640005
notes: PMID: 11185956
fast: false
reversible: false

640029
type: SpeciesReference
stoichiometry: 1.0
species: 305384

640017
type: SpeciesReference
stoichiometry: 1.0
species: 305382

305382
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: S1P

640005
type: SpeciesReference
stoichiometry: 1.0
species: 305373

305373
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: S1P_sub_1

305407
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: active_br_ErbB2

306046
type: Reaction
product: 636665
reactant: 636653
fast: false
reversible: false

636665
type: SpeciesReference
stoichiometry: 1.0
species: 305027

305027
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: a274_degraded

636653
type: SpeciesReference
stoichiometry: 1.0
species: 304976

305687
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: nuc.ERK1

306359
type: Reaction
modifier: 641037
product: 641025
reactant: 641013
notes: PP2A: PMID: 10995457 PMID: 15276015
fast: false
reversible: false

305036
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PP2A

641025
type: SpeciesReference
stoichiometry: 1.0
species: 305601

305601
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PKB/Akt_br_@PI3,4,5-P_sub_3

641013
type: SpeciesReference
stoichiometry: 1.0
species: 305604

305604
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PKB/Akt_br_@PI3,4,5-P_sub_3

305030
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: a285_degraded

305940
type: Reaction
modifier: 635381
product: 635369
reactant: 635357
notes: MEKK1@GTR+Rac1/Cdc42: PMID: 12456688 PMID: 12049732
fast: false
reversible: false

635369
type: SpeciesReference
stoichiometry: 1.0
species: 304879

635357
type: SpeciesReference
stoichiometry: 1.0
species: 304871

305998
type: Reaction
product: 636101
reactant: 636089
fast: false
reversible: false

636101
type: SpeciesReference
stoichiometry: 1.0
species: 305711

305711
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: nuc.RSK2

636089
type: SpeciesReference
stoichiometry: 1.0
species: 305708

306076
type: Reaction
modifier: 636977
product: 636965
reactant: 636953
notes: nuc.ERK1: PMID: 1748630 PMID: 1651323 PMID: 8386367 nuc.ERK2: PMID: 1748630 PMID: 1651323 PMID: 8386367
fast: false
reversible: false

636965
type: SpeciesReference
stoichiometry: 1.0
species: 305056

636953
type: SpeciesReference
stoichiometry: 1.0
species: 305054

305339
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(14-3-3/RGS7)

305640
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: nuc.STAT1

304884
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MEKK4

305391
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(active_br_c-Src/active_br_Pyk2)

305813
type: Reaction
modifier: 633864
modifier: 633852
product: 633840
reactant: 633828
notes: active Pyk2: PMID: 8849729 PMID: 10704819
fast: false
reversible: false

304658
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Grb2_br_@EGFR._br_Y1068/1086P/active_br_Pyk2)

633840
type: SpeciesReference
stoichiometry: 1.0
species: 304677

633828
type: SpeciesReference
stoichiometry: 1.0
species: 304672

304672
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-Src

305872
type: Reaction
product: 634623
reactant: 634611
notes: PMID: 10816576
fast: false
reversible: false

634623
type: SpeciesReference
stoichiometry: 1.0
species: 304778

304778
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304501
name: recyc.end._br_EGFR

304501
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: recycling_br_endsome

634611
type: SpeciesReference
stoichiometry: 1.0
species: 304774

304722
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/Rab5a)

306319
type: Reaction
modifier: 640520
product: 640508
reactant: 640496
notes: ErbB4: PMID: 10353604
fast: false
reversible: false

305726
type: Species
notes: ligand: PMID: 10214951 PMID: 11252954 PMID: 10880430 sutophosphorylation: PMID: 10880430
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Complex(active_br_ErbB4/HB-EGF / NRG-1 / 2 / 3 / 4_br_betacellulin / epiregulin)

640508
type: SpeciesReference
stoichiometry: 1.0
species: 305437

305437
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: PI3K(p85)_br_@ErbB4_br_Y1056P

640496
type: SpeciesReference
stoichiometry: 1.0
species: 305486

305486
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: PI3K(p85)

305473
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: E2F

306287
type: Reaction
modifier: 640141
product: 640129
reactant: 640116
notes: active c-Src (@Grb2): PMID: 11741929
fast: false
reversible: false

640129
type: SpeciesReference
stoichiometry: 1.0
species: 305397

305397
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_ADAMs

640116
type: SpeciesReference
stoichiometry: 1.0
species: 305395

305395
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: ADAMs

306189
type: Reaction
notes: Gbetagamma: PMID: 8245028 PMID: 8387502 PMID: 12790797 Galpha q: PMID: 8245028 PMID: 8387502 PMID: 12790797
modifier: 638611
modifier: 638599
modifier: 638586
modifier: 638574
reactant: 638550
modifier: 638623
fast: false
reversible: false
product: 638562

638550
type: SpeciesReference
stoichiometry: 1.0
species: 305226

305226
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PLC_beta

638562
type: SpeciesReference
stoichiometry: 1.0
species: 305229

304635
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Shc_br_@EGFR._br_Y1148/1173P/Grb2/active_br_SOS1)

306436
type: Reaction
modifier: 641937
product: 641925
reactant: 641913
notes: active ERK1/2: PMID: 10411321
fast: false
reversible: false

641925
type: SpeciesReference
stoichiometry: 1.0
species: 305708

641913
type: SpeciesReference
stoichiometry: 1.0
species: 305699

305862
type: Reaction
product: 634561
reactant: 634549
fast: false
reversible: false

634561
type: SpeciesReference
stoichiometry: 1.0
species: 304758

304758
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304490
name: a152_degraded

634549
type: SpeciesReference
stoichiometry: 1.0
species: 304755

304755
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304490
name: ErbB1_br_ligand

305764
type: Reaction
modifier: 633251
product: 633239
reactant: 633227
notes: active EGFR: PMID: 14560030
fast: false
reversible: false

633239
type: SpeciesReference
stoichiometry: 1.0
species: 304599

633227
type: SpeciesReference
stoichiometry: 1.0
species: 304593

305613
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479

305541
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: a687_degraded

305151
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: ADPR

305956
type: Reaction
modifier: 635561
notes: active MKK3: PMID: 8622669 active MKK4: PMID: 8622669 PMID: 9582321 active MKK6: PMID: 8622669
fast: false
product: 635537
reversible: false
modifier: 635573
reactant: 635525
modifier: 635549

635537
type: SpeciesReference
stoichiometry: 1.0
species: 304908

635525
type: SpeciesReference
stoichiometry: 1.0
species: 304905

304905
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: p38MAPK

306340
type: Reaction
product: 640760
reactant: 640748
fast: false
reversible: false

640760
type: SpeciesReference
stoichiometry: 1.0
species: 305575

305575
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Cyclin E

640748
type: SpeciesReference
stoichiometry: 1.0
species: 305461

305461
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: m.cyclin E

305358
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: EP3

306149
type: Reaction
modifier: 637961
modifier: 637949
product: 637937
reactant: 637925
notes: CD38: PMID: 12475791 ATP: PMID: 12475791
fast: false
reversible: false

305157
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: CD38

304538
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: ATP

637937
type: SpeciesReference
stoichiometry: 1.0
species: 305151

637925
type: SpeciesReference
stoichiometry: 1.0
species: 305145

306328
type: Reaction
modifier: 640604
product: 640592
reactant: 640580
notes: PP2: PMID: 14750954
fast: false
reversible: false

305449
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PP2

640592
type: SpeciesReference
stoichiometry: 1.0
species: 304532

640580
type: SpeciesReference
stoichiometry: 1.0
species: 304682

305059
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: p21

306334
type: Reaction
product: 640700
reactant: 640688
fast: false
reversible: false

640700
type: SpeciesReference
stoichiometry: 1.0
species: 305464

640688
type: SpeciesReference
stoichiometry: 1.0
species: 305457

305457
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: m.cyclin D

305705
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PDK1

305935
type: Reaction
modifier: 635309
product: 635297
reactant: 635285
notes: GTP+Rac+Cdc42: PMID: 7493928
fast: false
reversible: false

304745
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Cdc42/Rac/GTP)

635297
type: SpeciesReference
stoichiometry: 1.0
species: 304868

635285
type: SpeciesReference
stoichiometry: 1.0
species: 304861

305512
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: p53

306043
type: Reaction
product: 636641
reactant: 636629
fast: false
reversible: false

636641
type: SpeciesReference
stoichiometry: 1.0
species: 305021

305021
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-Fos

636629
type: SpeciesReference
stoichiometry: 1.0
species: 305018

305018
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: m.c-fos

304583
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Abi1/E3b1

306413
type: Reaction
product: 641649
reactant: 641637
fast: false
reversible: false

641649
type: SpeciesReference
stoichiometry: 1.0
species: 305046

641637
type: SpeciesReference
stoichiometry: 1.0
species: 305637

305897
type: Reaction
product: 634901
reactant: 634889
notes: PMID: 12456688 PMID: 11448952
fast: false
reversible: false

634901
type: SpeciesReference
stoichiometry: 1.0
species: 304807

634889
type: SpeciesReference
stoichiometry: 1.0
species: 305350

305350
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_c-Src

305799
type: Reaction
modifier: 633696
product: 633684
reactant: 633672
notes: active EGFR: PMID: 10473558 PMID: 1537335 PMID: 1689310 PMID: 1700866
fast: false
reversible: false

633684
type: SpeciesReference
stoichiometry: 1.0
species: 304643

633672
type: SpeciesReference
stoichiometry: 1.0
species: 304640

304640
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PLC_gamma

305455
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: cyclin E

305329
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/G_alpha_ _sub_12/13/G_beta/G_gamma)

305920
type: Reaction
modifier: 635141
product: 635129
reactant: 635117
notes: autophosphorylation: PMID: 11950587 PMID: 10551809
fast: false
reversible: false

304839
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Grb2_br_@EGFR._br_Y1068/1086P/PAK1_br_@GTP-Rac_br_or Cdc42)

635129
type: SpeciesReference
stoichiometry: 1.0
species: 304842

635117
type: SpeciesReference
stoichiometry: 1.0
species: 304839

305831
type: Reaction
reactant: 634165
reactant: 634153
notes: active Rin1@GTP+Ras: PMID: 11703925 GDP-GTP exchange: PMID: 11703925
fast: false
product: 634189
product: 634177
reversible: false
modifier: 634201

634165
type: SpeciesReference
stoichiometry: 1.0
species: 304705

634153
type: SpeciesReference
stoichiometry: 1.0
species: 304722

634189
type: SpeciesReference
stoichiometry: 1.0
species: 304694

634177
type: SpeciesReference
stoichiometry: 1.0
species: 304718

304718
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GTP/Rab5a)

306375
type: Reaction
modifier: 641241
modifier: 641229
product: 641217
reactant: 641205
notes: CAK: PMID: 1396589 PMID: 12459251 p27: PMID: 12760379 PMID: 7758941
fast: false
reversible: false

641217
type: SpeciesReference
stoichiometry: 1.0
species: 305652

305652
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Cyclin E/Cdk2)

641205
type: SpeciesReference
stoichiometry: 1.0
species: 305647

306211
type: Reaction
product: 639032
reactant: 639020
reactant: 639008
notes: PMID: 11875501
fast: false
reversible: false

639032
type: SpeciesReference
stoichiometry: 1.0
species: 305273

305273
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(LPA/active_br_LPA_sub_2)

639020
type: SpeciesReference
stoichiometry: 1.0
species: 305259

305259
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: LPA

639008
type: SpeciesReference
stoichiometry: 1.0
species: 305266

305266
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: LPA_sub_2

305984
type: Reaction
product: 635945
reactant: 635933
notes: PMID: 12706116 PMID: 11546808
fast: false
reversible: false

635945
type: SpeciesReference
stoichiometry: 1.0
species: 305680

635933
type: SpeciesReference
stoichiometry: 2.0
species: 305678

304787
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304490
name: Grb2_br_@early end.EGFR_br_Y1068/1086P

306403
type: Reaction
product: 641577
reactant: 641565
notes: PMID: 9287210
fast: false
reversible: false

641577
type: SpeciesReference
stoichiometry: 1.0
species: 305625

305625
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_STAT3

641565
type: SpeciesReference
stoichiometry: 1.0
species: 305632

305632
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: STAT3

306186
type: Reaction
modifier: 638538
modifier: 638526
product: 638514
reactant: 638502
notes: Galpha s: PMID: 14519441 Galpha i: PMID: 14519441
fast: false
reversible: false

638514
type: SpeciesReference
stoichiometry: 1.0
species: 305215

305215
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_adenylyl_br_cyclase

638502
type: SpeciesReference
stoichiometry: 1.0
species: 305212

305212
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: adenylyl_br_cyclase

305720
type: Species
notes: PMID: 10214951 PMID: 11252954
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: EGF / TGF_alpha_ / HB-EGF_br_amphiregulin / biregulin_br_betacellulin / epiregulin

305789
type: Reaction
product: 633576
reactant: 633564
reactant: 633551
fast: false
reversible: false

633576
type: SpeciesReference
stoichiometry: 1.0
species: 304629

633564
type: SpeciesReference
stoichiometry: 1.0
species: 304626

304626
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PI3K(p110)

633551
type: SpeciesReference
stoichiometry: 1.0
species: 304622

304622
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PI3K(p85)

305008
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Elk-1

304791
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304490
name: Complex(Grb2_br_@early end.EGFR_br_Y1068/1086P/c-Cbl_br_@EGFR.Y1045P)

305759
type: Reaction
reactant: 633143
product: 633167
notes: active PI3K: PMID: 11395417 PMID: 12515821 binding: PMID: 12127568 PMID: 10499589
fast: false
reactant: 633131
reversible: false
reactant: 633155
modifier: 633179

633143
type: SpeciesReference
stoichiometry: 1.0
species: 304572

633167
type: SpeciesReference
stoichiometry: 1.0
species: 304605

304605
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Abi1/E3b1/Eps8/active_br_SOS1)

633131
type: SpeciesReference
stoichiometry: 1.0
species: 304602

633155
type: SpeciesReference
stoichiometry: 1.0
species: 304583

305094
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(PI3K(p85)_br_@GTP-Ras/active_br_PI3K(p110))

306022
type: Reaction
modifier: 636401
product: 636389
reactant: 636377
notes: active JNK: PMID: 7935387 PMID: 8224842 PMID: 1749429
fast: false
reversible: false

304932
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_JNK

636389
type: SpeciesReference
stoichiometry: 1.0
species: 304980

304980
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-Jun

636377
type: SpeciesReference
stoichiometry: 1.0
species: 304976

305910
type: Reaction
modifier: 635033
product: 635021
reactant: 635009
notes: early end. EGFR: PMID: 10887178
fast: false
reversible: false

635021
type: SpeciesReference
stoichiometry: 1.0
species: 304833

304833
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: pl.m.SPRY2

635009
type: SpeciesReference
stoichiometry: 1.0
species: 304829

304829
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: SPRY2

306371
type: Reaction
product: 641193
reactant: 641181
reactant: 641169
notes: binding: PMID: 1388288 PMID: 11082295 PMID: 8513492
fast: false
reversible: false

641193
type: SpeciesReference
stoichiometry: 1.0
species: 305647

641181
type: SpeciesReference
stoichiometry: 1.0
species: 305575

641169
type: SpeciesReference
stoichiometry: 1.0
species: 305645

306273
type: Reaction
product: 639957
reactant: 639945
reactant: 639933
notes: PMID: 11875501
fast: false
reversible: false

639957
type: SpeciesReference
stoichiometry: 1.0
species: 305368

639945
type: SpeciesReference
stoichiometry: 1.0
species: 305358

639933
type: SpeciesReference
stoichiometry: 1.0
species: 305364

306086
type: Reaction
modifier: 637109
product: 637097
reactant: 637085
notes: SHP2: PMID: 12829245 PMID: 15276015 PMID: 11395417
fast: false
reversible: false

305506
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: SHIP2

637097
type: SpeciesReference
stoichiometry: 1.0
species: 305074

305074
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PI3,4P_sub_2

637085
type: SpeciesReference
stoichiometry: 1.0
species: 305077

305974
type: Reaction
modifier: 635825
modifier: 635813
product: 635801
reactant: 635789
notes: pl.m.Raf-1: PMID: 11023813 PMID: 1322500 PMID: 1326789 PMID: 8393135 MEKK1@GTP+Rac/Cdc42: PMID: 12456688 PMID: 8385802 PMID: 7624324
fast: false
reversible: false

635801
type: SpeciesReference
stoichiometry: 1.0
species: 304938

304938
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_MKK1

635789
type: SpeciesReference
stoichiometry: 1.0
species: 305491

305491
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MKK1

306354
type: Reaction
modifier: 640965
product: 640953
reactant: 640941
notes: degradation: PMID: 12459251 PMID: 8769642 PMID: 8861947 SCFFbw7: PMID: 11533444
fast: false
reversible: false

305572
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: SCF_super_Fbw7

640953
type: SpeciesReference
stoichiometry: 1.0
species: 305476

305476
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: a646_degraded

640941
type: SpeciesReference
stoichiometry: 1.0
species: 305577

305577
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Cyclin E

305780
type: Reaction
modifier: 633455
product: 633443
reactant: 633431
reactant: 633419
notes: Grb2@EGFR.Y1068/1086P: PMID: 11943184 PMID: 10648629 PMID: 10913131
fast: false
reversible: false

633443
type: SpeciesReference
stoichiometry: 1.0
species: 304619

633431
type: SpeciesReference
stoichiometry: 1.0
species: 304616

633419
type: SpeciesReference
stoichiometry: 1.0
species: 304569

306071
type: Reaction
modifier: 636905
product: 636893
reactant: 636881
notes: active p38MAPK: PMID: 11495913 PMID: 10811125 PMID: 10581258
fast: false
reversible: false

636893
type: SpeciesReference
stoichiometry: 1.0
species: 305512

636881
type: SpeciesReference
stoichiometry: 1.0
species: 305508

305508
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: p53

306165
type: Reaction
modifier: 638178
product: 638166
product: 638154
reactant: 638142
fast: false
reversible: false

638166
type: SpeciesReference
stoichiometry: 1.0
species: 304713

638154
type: SpeciesReference
stoichiometry: 1.0
species: 305186

638142
type: SpeciesReference
stoichiometry: 1.0
species: 305184

305828
type: Reaction
reactant: 634093
fast: false
modifier: 634129
modifier: 634141
product: 634105
notes: RasGAP@EGFR.Y992P:PMID: 14663478 PMID: 10740269 hydrolysis: PMID: 14663478
reversible: false
product: 634117

634093
type: SpeciesReference
stoichiometry: 1.0
species: 304702

304702
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GTP/Ras)

634105
type: SpeciesReference
stoichiometry: 1.0
species: 304710

304710
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/Ras)

634117
type: SpeciesReference
stoichiometry: 1.0
species: 304713

305740
type: Reaction
modifier: 632962
modifier: 632950
product: 632938
reactant: 632926
notes: SHP1@EGFR.Y1173P: PMID: 9733788 SHP2@EGFR: PMID: 14560030
fast: false
reversible: false

632938
type: SpeciesReference
stoichiometry: 1.0
species: 304527

632926
type: SpeciesReference
stoichiometry: 1.0
species: 304532

304524
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(ErbB1_br_ligand/EGFR)

304969
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-jun

304922
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_MKK7

306206
type: Reaction
product: 638960
reactant: 638948
reactant: 638936
fast: false
reversible: false

638960
type: SpeciesReference
stoichiometry: 1.0
species: 305246

638948
type: SpeciesReference
stoichiometry: 1.0
species: 305242

305242
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: calpain

638936
type: SpeciesReference
stoichiometry: 1.0
species: 305132

304557
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Shc_br_@EGFR._br_Y1148/1173P

305160
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: CaM

305332
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: 14-3-3

305981
type: Reaction
modifier: 635921
modifier: 635909
product: 635897
reactant: 635885
notes: active MKK1/2: PMID: 8622669 PMID: 9836645 PMID: 1318193 PMID: 8393135 PMID: 1411546
fast: false
reversible: false

635897
type: SpeciesReference
stoichiometry: 1.0
species: 305678

635885
type: SpeciesReference
stoichiometry: 1.0
species: 305675

305675
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: ERK1

306298
type: Reaction
modifier: 640297
product: 640284
reactant: 640271
notes: active ErbB2: PMID: 9461599
fast: false
reversible: false

640284
type: SpeciesReference
stoichiometry: 1.0
species: 305413

305413
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Chk_br_@ErbB2_br_Y1248P

640271
type: SpeciesReference
stoichiometry: 1.0
species: 305411

306366
type: Reaction
modifier: 641109
product: 641097
reactant: 641085
notes: Ca+CaM+CaMKII: PMID: 14652114
fast: false
reversible: false

641097
type: SpeciesReference
stoichiometry: 1.0
species: 305590

641085
type: SpeciesReference
stoichiometry: 1.0
species: 305595

305969
type: Reaction
modifier: 635741
product: 635729
reactant: 635717
notes: active MKK7: PMID: 12624093 PMID: 9836645 PMID: 9384583 PMID: 9405446 PMID: 9312068
fast: false
reversible: false

635729
type: SpeciesReference
stoichiometry: 1.0
species: 304932

635717
type: SpeciesReference
stoichiometry: 1.0
species: 304927

304927
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: JNK

305301
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/G_alpha_ _sub_s/G_beta/G_gamma)

306172
type: Reaction
modifier: 638286
modifier: 638274
product: 638262
reactant: 638250
notes: Galpha q: PMID: 12790797 PMID: 12771155 Galpha12/13: PMID: 12515866 PMID: 12771155
fast: false
reversible: false

638262
type: SpeciesReference
stoichiometry: 1.0
species: 305196

638250
type: SpeciesReference
stoichiometry: 1.0
species: 305191

305191
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: LARG

306083
type: Reaction
modifier: 637073
product: 637061
reactant: 637049
notes: active c-Myc: PMID: 10454538 PMID: 12565816
fast: false
reversible: false

637061
type: SpeciesReference
stoichiometry: 1.0
species: 305067

637049
type: SpeciesReference
stoichiometry: 1.0
species: 305062

305062
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: p15

305129
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304509
name: PP1

306002
type: Reaction
modifier: 636149
modifier: 636137
product: 636125
reactant: 636113
notes: active ERK1/2: PMID: 9242373 PMID: 7673108 PMID: 7478566 PMID: 7592690 PMID: 8621459 active RSK: PMID: 9242373
fast: false
reversible: false

636125
type: SpeciesReference
stoichiometry: 1.0
species: 304948

304948
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Grb2_br_@early end.EGFR_br_Y1068/1086P/SOS1)

636113
type: SpeciesReference
stoichiometry: 1.0
species: 304783

304783
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304490
name: Complex(Grb2_br_@early end.EGFR_br_Y1068/1086P/active_br_SOS1)

305305
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/G_alpha_ _sub_s)

306066
type: Reaction
product: 636869
reactant: 636857
fast: false
reversible: false

636869
type: SpeciesReference
stoichiometry: 1.0
species: 305508

636857
type: SpeciesReference
stoichiometry: 1.0
species: 305003

305003
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: m.p53

304821
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304506
name: lyso._br_EGFR

304506
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: lysosome

306258
type: Reaction
product: 639813
reactant: 639801
reactant: 639789
notes: PMID: 14607243 PMID: 10862767
fast: false
reversible: false

639813
type: SpeciesReference
stoichiometry: 1.0
species: 305339

639801
type: SpeciesReference
stoichiometry: 1.0
species: 305332

639789
type: SpeciesReference
stoichiometry: 1.0
species: 305335

304951
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Grb2_br_@EGFR._br_Y1068/1086P/SOS1)

306162
type: Reaction
modifier: 638130
product: 638118
reactant: 638106
notes: active PKA: PMID: 15150446
fast: false
reversible: false

638118
type: SpeciesReference
stoichiometry: 1.0
species: 305181

305181
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PLD

638106
type: SpeciesReference
stoichiometry: 1.0
species: 305177

306345
type: Reaction
product: 640832
reactant: 640820
fast: false
reversible: false

640832
type: SpeciesReference
stoichiometry: 1.0
species: 304856

304856
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: apoptosis

640820
type: SpeciesReference
stoichiometry: 1.0
species: 305512

306243
type: Reaction
modifier: 639608
product: 639572
fast: false
notes: RGS4: PMID: 14607243 PMID: 11356902 RGS7: PMID: 14607243 PMID: 11356902 Galpha: PMID: 7834744 PMID: 11941304 PMID: 12354102
reversible: false
modifier: 639596
modifier: 639584
reactant: 639548
product: 639560

639572
type: SpeciesReference
stoichiometry: 1.0
species: 304713

639548
type: SpeciesReference
stoichiometry: 1.0
species: 305293

639560
type: SpeciesReference
stoichiometry: 1.0
species: 305297

306181
type: Reaction
modifier: 638418
modifier: 638406
product: 638394
reactant: 638382
notes: active adenylyl cyclase: PMID: 14519441 active adenylyl cyclase II: PMID: 14519441
fast: false
reversible: false

638394
type: SpeciesReference
stoichiometry: 1.0
species: 305202

305202
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: cAMP

638382
type: SpeciesReference
stoichiometry: 1.0
species: 304538

304574
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Grb2/SOS1)

305220
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: adenylyl_br_cyclase II

305342
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: RGS4

306330
type: Reaction
fast: false
modifier: 640640
reactant: 640616
modifier: 640676
reversible: false
modifier: 640652
product: 640628
modifier: 640664
notes: CREB: PMID: 10066798 PMID: 12459251 nuc.STAT3: PMID: 10458605 PMID: 12459251 nuc.c-Jun: PMID: 10790372 PMID: 12459251 E2F: PMID: 9584162 PMID: 12459251

640616
type: SpeciesReference
stoichiometry: 1.0
species: 305452

304988
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: nuc.c-Jun

640628
type: SpeciesReference
stoichiometry: 1.0
species: 305457

304963
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: CREB

306054
type: Reaction
modifier: 636737
modifier: 636725
product: 636713
reactant: 636701
notes: active ERK1: PMID: 15136564 active ERK2: PMID: 15136564 active JNK: PMID: 15136564
fast: false
reversible: false

636713
type: SpeciesReference
stoichiometry: 1.0
species: 305033

636701
type: SpeciesReference
stoichiometry: 1.0
species: 305021

304737
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: RN-tre

305659
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Raf-1

306203
type: Reaction
modifier: 638924
product: 638912
product: 638899
reactant: 638887
notes: active calpain: PMID: 8131842
fast: false
reversible: false

638912
type: SpeciesReference
stoichiometry: 1.0
species: 305233

305233
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: truncated_br_PLC_beta

638899
type: SpeciesReference
stoichiometry: 1.0
species: 305239

638887
type: SpeciesReference
stoichiometry: 1.0
species: 305226

306105
type: Reaction
modifier: 637349
modifier: 637337
product: 637325
reactant: 637313
notes: autophosphorylation: PMID: 12829245 active PDK2: PMID: 12829245
fast: false
reversible: false

305102
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_PDK2

637325
type: SpeciesReference
stoichiometry: 1.0
species: 305604

637313
type: SpeciesReference
stoichiometry: 1.0
species: 305601

306199
type: Reaction
reversible: false
modifier: 638827
modifier: 638875
notes: Gbetagamma: PMID: 9307019 PMID: 12790797 active PKA: PMID: 10893237 PMID: 12790797
fast: false
modifier: 638839
product: 638815
modifier: 638863
reactant: 638803
modifier: 638851

638815
type: SpeciesReference
stoichiometry: 1.0
species: 305256

305256
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: truncated_br_PLC_beta

638803
type: SpeciesReference
stoichiometry: 1.0
species: 305236

304518
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: EGFR

306014
type: Reaction
reactant: 636293
modifier: 636317
product: 636305
notes: CREB: PMID: 10471787 nuc.c-Jun: PMID: 10471787 AP-1: PMID: 10471787
modifier: 636329
modifier: 636341
fast: false
reversible: false

636293
type: SpeciesReference
stoichiometry: 1.0
species: 304969

636305
type: SpeciesReference
stoichiometry: 1.0
species: 304971

304971
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: m.c-jun

305043
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: AP-1_br_c-Fos+c-Jun

305628
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: nuc.STAT1

305804
type: Reaction
modifier: 633768
product: 633756
reactant: 633744
notes: autophosphorylation: PMID: 14963038 PMID: 10704819
fast: false
reversible: false

633756
type: SpeciesReference
stoichiometry: 1.0
species: 304658

633744
type: SpeciesReference
stoichiometry: 1.0
species: 304664

305166
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: phosphatidyl_br_choline

305280
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/G_alpha_ _sub_i/G_beta/G_gamma)

306050
type: Reaction
product: 636689
reactant: 636677
notes: PMID: 15136564
fast: false
reversible: false

636689
type: SpeciesReference
stoichiometry: 1.0
species: 305030

636677
type: SpeciesReference
stoichiometry: 1.0
species: 305021

305013
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PP2B

306284
type: Reaction
product: 640103
reactant: 640091
reactant: 640079
notes: PMID: 8849729 PMID: 11252954
fast: false
reversible: false

640103
type: SpeciesReference
stoichiometry: 1.0
species: 305391

640091
type: SpeciesReference
stoichiometry: 1.0
species: 304667

640079
type: SpeciesReference
stoichiometry: 1.0
species: 304672

305887
type: Reaction
modifier: 634805
product: 634792
reactant: 634779
reactant: 634766
notes: early end.EGFR: PMID: 15210722 c-Cbl: PMID: 10635327
fast: false
reversible: false

634792
type: SpeciesReference
stoichiometry: 1.0
species: 304791

634779
type: SpeciesReference
stoichiometry: 1.0
species: 304794

304794
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-Cbl

634766
type: SpeciesReference
stoichiometry: 1.0
species: 304787

306289
type: Reaction
modifier: 640193
product: 640180
product: 640167
reactant: 640154
notes: active ADAMs: PMID: 10622253 PMID: 15337756
fast: false
reversible: false

640180
type: SpeciesReference
stoichiometry: 1.0
species: 305404

640167
type: SpeciesReference
stoichiometry: 1.0
species: 305239

640154
type: SpeciesReference
stoichiometry: 1.0
species: 305401

306063
type: Reaction
product: 636845
reactant: 636833
reactant: 636821
notes: PMID: 15136564 PMID: 15136564 PMID: 9069263
fast: false
reversible: false

636845
type: SpeciesReference
stoichiometry: 1.0
species: 305043

636833
type: SpeciesReference
stoichiometry: 1.0
species: 304984

304984
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: nuc.c-Jun

636821
type: SpeciesReference
stoichiometry: 1.0
species: 305040

305249
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PLC_beta

304750
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/Rac/Cdc42)

304811
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Ubc-H7

304959
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: CREB

306238
type: Reaction
modifier: 639536
product: 639500
reactant: 639476
reactant: 639464
product: 639512
fast: false
reversible: false
product: 639488
modifier: 639524
notes: GPCR: PMID: 9660746 PMID: 7834744 PMID: 11941304 PMID: 12354102

305387
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(S1P/active_br_S1P_sub_2/3)

639500
type: SpeciesReference
stoichiometry: 1.0
species: 305293

639476
type: SpeciesReference
stoichiometry: 1.0
species: 304705

639464
type: SpeciesReference
stoichiometry: 1.0
species: 305289

639512
type: SpeciesReference
stoichiometry: 1.0
species: 304694

639488
type: SpeciesReference
stoichiometry: 1.0
species: 305277

305692
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: RSK2

305847
type: Reaction
modifier: 634405
modifier: 634393
product: 634381
reactant: 634357
reversible: false
product: 634369
notes: Vav2@EGFR.Y992/1148P: PMID: 12454019 active SOS: PMID: 12127568 GDP-GTP exchange: PMID: 12454019 PMID: 12127568
reactant: 634345
fast: false

634381
type: SpeciesReference
stoichiometry: 1.0
species: 304694

634357
type: SpeciesReference
stoichiometry: 1.0
species: 304705

634369
type: SpeciesReference
stoichiometry: 1.0
species: 304745

634345
type: SpeciesReference
stoichiometry: 1.0
species: 304750

305900
type: Reaction
modifier: 634949
modifier: 634937
product: 634925
reactant: 634913
notes: c-Cbl@EGFR.Y1045P: PMID: 12456688 PMID: 15210722 PMID: 10531381 PMID: 11448952 PMID: 9851973 Ubc-H7: PMID: 15210722 PMID: 10531381 PMID: 11448952
fast: false
reversible: false

304799
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304490
name: Complex(Grb2_br_@early end.EGFR_br_Y1068/1086P/c-Cbl_br_@EGFR.Y1045P)

634925
type: SpeciesReference
stoichiometry: 1.0
species: 304815

634913
type: SpeciesReference
stoichiometry: 1.0
species: 304771

305105
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PKC

305751
type: Reaction
product: 633083
reactant: 633071
reactant: 633059
notes: PMID: 8479541 PMID: 12006650
fast: false
reversible: false

633083
type: SpeciesReference
stoichiometry: 1.0
species: 304574

633071
type: SpeciesReference
stoichiometry: 1.0
species: 304565

633059
type: SpeciesReference
stoichiometry: 1.0
species: 304572

305429
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Grb7@ErbB3_br_Y1180/1243P

305097
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PTEN

306409
type: Reaction
product: 641625
reactant: 641613
notes: PMID: 9287210
fast: false
reversible: false

641625
type: SpeciesReference
stoichiometry: 1.0
species: 305640

641613
type: SpeciesReference
stoichiometry: 1.0
species: 305623

305530
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PP1

305005
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Elk-1

306028
type: Reaction
product: 636449
reactant: 636437
notes: PMID: 9069263
fast: false
reversible: false

636449
type: SpeciesReference
stoichiometry: 1.0
species: 304988

636437
type: SpeciesReference
stoichiometry: 2.0
species: 304984

305916
type: Reaction
modifier: 635105
product: 635093
reactant: 635081
notes: GTP+Rac+Cdc42: PMID: 11950587 PMID: 10551809 PMID: 10559936 PMID: 12522133 PMID: 8107774
fast: false
reversible: false

635093
type: SpeciesReference
stoichiometry: 1.0
species: 304839

635081
type: SpeciesReference
stoichiometry: 1.0
species: 304690

305818
type: Reaction
modifier: 633960
modifier: 633948
product: 633936
reactant: 633924
notes: active c-Src@Shc.Y317: PMID: 9990038 PMID: 7797556 KDI1: PMID: 12842895 PMID: 10075741
fast: false
reversible: false

633936
type: SpeciesReference
stoichiometry: 1.0
species: 304682

633924
type: SpeciesReference
stoichiometry: 1.0
species: 304532

305952
type: Reaction
modifier: 635513
product: 635501
reactant: 635489
notes: MLK3@GTP+Rac/Cdc42: PMID: 9003778
fast: false
reversible: false

635501
type: SpeciesReference
stoichiometry: 1.0
species: 304900

635489
type: SpeciesReference
stoichiometry: 1.0
species: 304897

304897
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MKK6

306109
type: Reaction
modifier: 637385
product: 637373
reactant: 637361
notes: active PDK1: PMID: 9368760 PMID: 10021376 PMID: 12829245
fast: false
reversible: false

637373
type: SpeciesReference
stoichiometry: 1.0
species: 305608

637361
type: SpeciesReference
stoichiometry: 1.0
species: 305604

306377
type: Reaction
modifier: 641289
product: 641277
product: 641265
reactant: 641253
notes: Cdk2: PMID: 8769642 PMID: 8861947
fast: false
reversible: false

641277
type: SpeciesReference
stoichiometry: 1.0
species: 305577

641265
type: SpeciesReference
stoichiometry: 1.0
species: 305645

641253
type: SpeciesReference
stoichiometry: 1.0
species: 305652

306400
type: Reaction
product: 641553
reactant: 641541
notes: PMID: 9287210
fast: false
reversible: false

641553
type: SpeciesReference
stoichiometry: 1.0
species: 305623

641541
type: SpeciesReference
stoichiometry: 1.0
species: 305634

306396
type: Reaction
modifier: 641505
fast: false
notes: active EGFR: PMID: 14750954 PMID: 8140422 PMID: 9287210 active c-Src: PMID: 14963038 PMID: 7541555 PMID: 10358079 KDI1: PMID: 12842895
modifier: 641517
modifier: 641529
reactant: 641469
modifier: 641493
product: 641481
reversible: false

641469
type: SpeciesReference
stoichiometry: 1.0
species: 305616

305616
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: STAT3

641481
type: SpeciesReference
stoichiometry: 1.0
species: 305632

305206
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(cAMP/R)

305884
type: Reaction
modifier: 634753
product: 634740
reactant: 634727
notes: early end.EGFR: PMID: 12006650 PMID: 11084343
fast: false
reversible: false

634740
type: SpeciesReference
stoichiometry: 1.0
species: 304787

634727
type: SpeciesReference
stoichiometry: 1.0
species: 304565

305173
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PLD

305808
type: Reaction
modifier: 633816
modifier: 633804
product: 633792
reactant: 633780
notes: Galpha 13: PMID: 10821841 PMID: 8849729 GPCR: PMID: 10704819 PMID: 11252954 autophosphorylation: PMID: 14963038 PMID: 10704819 cyt.Ca: PMID: 10704819 PMID: 11252954
fast: false
reversible: false

633792
type: SpeciesReference
stoichiometry: 1.0
species: 304667

633780
type: SpeciesReference
stoichiometry: 1.0
species: 304647

305965
type: Reaction
modifier: 635705
product: 635693
reactant: 635681
notes: active MKK4: PMID: 12624093 PMID: 8622669 PMID: 11451947 PMID: 9312068
fast: false
reversible: false

635693
type: SpeciesReference
stoichiometry: 1.0
species: 304927

635681
type: SpeciesReference
stoichiometry: 1.0
species: 304925

305519
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Shc_br_@ErbB2_br_Y1196/1221/22P

304836
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(c-Cbl/pl.m.SPRY2)

306418
type: Reaction
modifier: 641709
product: 641697
reactant: 641685
notes: SHP-2: PMID: 12270932
fast: false
reversible: false

641697
type: SpeciesReference
stoichiometry: 1.0
species: 305628

641685
type: SpeciesReference
stoichiometry: 1.0
species: 305640

306254
type: Reaction
modifier: 639777
product: 639765
product: 639753
reactant: 639741
notes: Galpha: PMID: 7834744 PMID: 11941304 PMID: 12354102
fast: false
reversible: false

639765
type: SpeciesReference
stoichiometry: 1.0
species: 304713

639753
type: SpeciesReference
stoichiometry: 1.0
species: 305305

639741
type: SpeciesReference
stoichiometry: 1.0
species: 305308

306156
type: Reaction
modifier: 638045
product: 638033
product: 638021
reactant: 638009
notes: active PLD: PMID: 15150446
fast: false
reversible: false

638033
type: SpeciesReference
stoichiometry: 1.0
species: 305521

638021
type: SpeciesReference
stoichiometry: 1.0
species: 305169

638009
type: SpeciesReference
stoichiometry: 1.0
species: 305166

306073
type: Reaction
modifier: 636941
product: 636929
reactant: 636917
notes: MKP: PMID: 8221888 PMID: 8570188
fast: false
reversible: false

305049
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MKP

636929
type: SpeciesReference
stoichiometry: 1.0
species: 305687

636917
type: SpeciesReference
stoichiometry: 1.0
species: 305684

305534
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Rb

304803
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_c-Src

306427
type: Reaction
modifier: 641829
modifier: 641817
product: 641805
reactant: 641793
notes: active c-Src: PMID: 7517401 PMID: 11376654 PMID: 11023813 PMID: 12551923 PMID: 10205168 active PAK1: PMID: 11376654 PMID: 11023813 PMID: 12551923 PMID: 10205168
fast: false
reversible: false

641805
type: SpeciesReference
stoichiometry: 1.0
species: 305665

305665
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: pl.m.Raf-1

641793
type: SpeciesReference
stoichiometry: 1.0
species: 305655

305655
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: pl.m.Raf-1

306250
type: Reaction
product: 639729
reactant: 639717
reactant: 639704
notes: PMID: 7834744 PMID: 11941304 PMID: 12354102
fast: false
reversible: false

639729
type: SpeciesReference
stoichiometry: 1.0
species: 305301

639717
type: SpeciesReference
stoichiometry: 1.0
species: 305277

639704
type: SpeciesReference
stoichiometry: 1.0
species: 305305

306152
type: Reaction
product: 637997
reactant: 637985
reactant: 637973
notes: PMID: 14652114
fast: false
reversible: false

637997
type: SpeciesReference
stoichiometry: 1.0
species: 305164

305164
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(CaM/cyt._br_Ca_super_2+)

637985
type: SpeciesReference
stoichiometry: 1.0
species: 305160

637973
type: SpeciesReference
stoichiometry: 1.0
species: 305132

305853
type: Reaction
modifier: 634501
product: 634489
reactant: 634477
notes: GTP+Rab5a: PMID: 11703925 PMID: 11062256
fast: false
reversible: false

634489
type: SpeciesReference
stoichiometry: 1.0
species: 304767

304767
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304490
name: Complex(ErbB1_br_ligand/early end._br_EGFR)

634477
type: SpeciesReference
stoichiometry: 1.0
species: 304532

305755
type: Reaction
modifier: 633119
product: 633107
reactant: 633095
notes: active EGFR: PMID: 8479540 PMID: 12006650 PMID: 11084343
fast: false
reversible: false

633107
type: SpeciesReference
stoichiometry: 1.0
species: 304577

304577
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Grb2_br_@EGFR._br_Y1068/1086P/active_br_SOS1)

633095
type: SpeciesReference
stoichiometry: 1.0
species: 304574

305947
type: Reaction
modifier: 635441
product: 635429
reactant: 635417
notes: GTP+Rac+Cdc42: PMID: 9305638
fast: false
reversible: false

635429
type: SpeciesReference
stoichiometry: 1.0
species: 304887

635417
type: SpeciesReference
stoichiometry: 1.0
species: 304884

306025
type: Reaction
product: 636425
reactant: 636413
fast: false
reversible: false

636425
type: SpeciesReference
stoichiometry: 1.0
species: 304984

636413
type: SpeciesReference
stoichiometry: 1.0
species: 304980

304865
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MEKK1

306008
type: Reaction
modifier: 636245
modifier: 636233
product: 636221
reactant: 636209
notes: active ERK1/2: PMID: 9242373 PMID: 7673108 PMID: 7478566 PMID: 7592690 PMID: 8621459 active RSK: PMID: 9242373
fast: false
reversible: false

636221
type: SpeciesReference
stoichiometry: 1.0
species: 304954

636209
type: SpeciesReference
stoichiometry: 1.0
species: 304635

305932
type: Reaction
product: 635273
reactant: 635261
notes: PMID: 15209377
fast: false
reversible: false

635273
type: SpeciesReference
stoichiometry: 1.0
species: 304856

635261
type: SpeciesReference
stoichiometry: 1.0
species: 304853

305745
type: Reaction
modifier: 633011
modifier: 632998
product: 632986
reactant: 632974
notes: active EGFR: PMID: 12006650 PMID: 8034616 PMID: 9544989 PMID: 7518560 PMID: 7527043 KDI1: PMID: 12842895
fast: false
reversible: false

632986
type: SpeciesReference
stoichiometry: 1.0
species: 304557

632974
type: SpeciesReference
stoichiometry: 1.0
species: 304550

304550
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Shc

304995
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: p53

305996
type: Reaction
modifier: 636077
product: 636065
reactant: 636053
notes: active PDK1: PMID: 12016217 PMID: 10480933 PMID: 10856237
fast: false
reversible: false

636065
type: SpeciesReference
stoichiometry: 1.0
species: 305708

636053
type: SpeciesReference
stoichiometry: 1.0
species: 305696

305696
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: RSK2

306444
type: Reaction
modifier: 642009
modifier: 641997
product: 641985
reactant: 641973
notes: DAG: PMID: 12877655 PMID: 12727851 phosphatidic acid: PMID: 128777655 PMID: 12727851
fast: false
reversible: false

641985
type: SpeciesReference
stoichiometry: 1.0
species: 305717

305717
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: pl.m._beta_ 2-chimaerin

641973
type: SpeciesReference
stoichiometry: 1.0
species: 305714

305714
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: _beta_2-chimaerin

306034
type: Reaction
modifier: 636521
product: 636509
reactant: 636497
notes: nuc.ERK1: PMID: 8846788 PMID: 10329725 PMID: 12706116 PMID: 8386592 PMID: 11309409 nuc.ERK2: PMID: 8846788 PMID: 10329725 PMID: 12706116 PMID: 8386592 PMID: 11309409 JNK(UV): PMID: 8846788 PMID: 11309409
fast: false
reversible: false

636509
type: SpeciesReference
stoichiometry: 1.0
species: 305008

636497
type: SpeciesReference
stoichiometry: 1.0
species: 305005

306093
type: Reaction
modifier: 637193
modifier: 637181
product: 637169
reactant: 637157
notes: active PI3K: PMID: 8399352 PMID: 10358929 PMID: 12829245 PMID: 15276015 PMID: 11395417
fast: false
reversible: false

637169
type: SpeciesReference
stoichiometry: 1.0
species: 305077

637157
type: SpeciesReference
stoichiometry: 1.0
species: 305082

306098
type: Reaction
modifier: 637265
product: 637253
reactant: 637241
notes: GTP+Ras: PMID: 14663478 PMID: 9529605 PMID: 11395417 PMID: 12006650 PMID: 10740269
fast: false
reversible: false

637253
type: SpeciesReference
stoichiometry: 1.0
species: 305094

637241
type: SpeciesReference
stoichiometry: 1.0
species: 304629

305858
type: Reaction
product: 634537
product: 634525
reactant: 634513
fast: false
reversible: false

634537
type: SpeciesReference
stoichiometry: 1.0
species: 304771

634525
type: SpeciesReference
stoichiometry: 1.0
species: 304755

634513
type: SpeciesReference
stoichiometry: 1.0
species: 304767

305894
type: Reaction
modifier: 634877
product: 634865
reactant: 634853
notes: c-Cbl@EGFR.Y1045P: PMID: 12456688 PMID: 11448952
fast: false
reversible: false

634865
type: SpeciesReference
stoichiometry: 1.0
species: 305350

634853
type: SpeciesReference
stoichiometry: 1.0
species: 304803

306336
type: Reaction
modifier: 640736
product: 640724
reactant: 640712
notes: E2F: PMID: 8668155 PMID: 12760379 PMID: 11960696
fast: false
reversible: false

640724
type: SpeciesReference
stoichiometry: 1.0
species: 305461

640712
type: SpeciesReference
stoichiometry: 1.0
species: 305455

305611
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PKB/Akt

305120
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304509
name: IP_sub_3_endsub_R

305488
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304509
name: PP2A

306245
type: Reaction
reversible: false
modifier: 639680
reactant: 639632
reactant: 639620
product: 639668
fast: false
product: 639656
product: 639644
modifier: 639692
notes: GPCR: PMID: 9660746 PMID: 7834744 PMID: 11941304 PMID: 12354102

639632
type: SpeciesReference
stoichiometry: 1.0
species: 304705

639620
type: SpeciesReference
stoichiometry: 1.0
species: 305301

639668
type: SpeciesReference
stoichiometry: 1.0
species: 304694

639656
type: SpeciesReference
stoichiometry: 1.0
species: 305308

639644
type: SpeciesReference
stoichiometry: 1.0
species: 305277

306177
type: Reaction
product: 638370
product: 638358
reactant: 638346
reactant: 638334
notes: PMID: 7803765
fast: false
reversible: false

638370
type: SpeciesReference
stoichiometry: 1.0
species: 305206

638358
type: SpeciesReference
stoichiometry: 1.0
species: 305126

638346
type: SpeciesReference
stoichiometry: 1.0
species: 305202

638334
type: SpeciesReference
stoichiometry: 1.0
species: 305209

305209
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(R/PKA)

306147
type: Reaction
modifier: 637913
product: 637901
reactant: 637889
notes: CD38: PMID: 12475791
fast: false
reversible: false

637901
type: SpeciesReference
stoichiometry: 1.0
species: 305145

637889
type: SpeciesReference
stoichiometry: 1.0
species: 305154

305154
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: NAD_super_+

305937
type: Reaction
modifier: 635345
product: 635333
reactant: 635321
notes: GTP+Ras+Cdc42: PMID: 9305638
fast: false
reversible: false

635333
type: SpeciesReference
stoichiometry: 1.0
species: 304871

635321
type: SpeciesReference
stoichiometry: 1.0
species: 304865

305422
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: PI3K(p85)@ErbB3_br_Y1035/1178/1203/05_br_1241/1257/1270P

306183
type: Reaction
modifier: 638454
modifier: 638490
modifier: 638478
notes: Gbetagamma: PMID: 14519441
fast: false
reactant: 638430
reversible: false
modifier: 638466
product: 638442

638430
type: SpeciesReference
stoichiometry: 1.0
species: 305220

638442
type: SpeciesReference
stoichiometry: 1.0
species: 305223

305786
type: Reaction
modifier: 633539
product: 633527
product: 633515
reactant: 633503
notes: SHP2@EGFR: PMID: 12024020 PMID: 15550174
fast: false
reversible: false

633527
type: SpeciesReference
stoichiometry: 1.0
species: 304616

633515
type: SpeciesReference
stoichiometry: 1.0
species: 304569

633503
type: SpeciesReference
stoichiometry: 1.0
species: 304619

306228
type: Reaction
product: 639368
reactant: 639356
reactant: 639344
notes: PMID: 7834744 PMID: 11941304
fast: false
reversible: false

639368
type: SpeciesReference
stoichiometry: 1.0
species: 305329

639356
type: SpeciesReference
stoichiometry: 1.0
species: 305277

639344
type: SpeciesReference
stoichiometry: 1.0
species: 305326

306264
type: Reaction
product: 639873
reactant: 639861
fast: false
reversible: false

639873
type: SpeciesReference
stoichiometry: 1.0
species: 305546

639861
type: SpeciesReference
stoichiometry: 1.0
species: 305070

305070
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: m.p21

306132
type: Reaction
modifier: 637685
modifier: 637673
product: 637661
reactant: 637649
notes: PP1: PMID: 12167631 PP2A: PMID: 12167631
fast: false
reversible: false

637661
type: SpeciesReference
stoichiometry: 1.0
species: 305120

637649
type: SpeciesReference
stoichiometry: 1.0
species: 305122

305735
type: Reaction
product: 632842
reactant: 632830
reactant: 632818
notes: PMID: 11252954 PMID: 7834741 PMID: 9708728
fast: false
reversible: false

632842
type: SpeciesReference
stoichiometry: 1.0
species: 304527

632830
type: SpeciesReference
stoichiometry: 1.0
species: 304524

632818
type: SpeciesReference
stoichiometry: 1.0
species: 304524

305771
type: Reaction
modifier: 633335
modifier: 633323
product: 633311
reactant: 633299
notes: active EGFR: PMID: 12454019 active PI3K: PMID: 12454019 PMID: 11395417 PMID: 8939609 PMID: 9438848
fast: false
reversible: false

633311
type: SpeciesReference
stoichiometry: 1.0
species: 305498

633299
type: SpeciesReference
stoichiometry: 1.0
species: 305500

305500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Vav2

306196
type: Reaction
product: 638731
modifier: 638755
modifier: 638791
reactant: 638719
notes: Gbetagamma: PMID: 9307019 PMID: 12790797 active PKA: PMID: 10893237 PMID: 12790797
modifier: 638767
modifier: 638743
fast: false
modifier: 638779
reversible: false

638731
type: SpeciesReference
stoichiometry: 1.0
species: 305249

638719
type: SpeciesReference
stoichiometry: 1.0
species: 305229

305561
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: LIMK1

306218
type: Reaction
product: 639176
reactant: 639164
reactant: 639152
notes: PMID: 7834744 PMID: 11941304 PMID: 12354102
fast: false
reversible: false

639176
type: SpeciesReference
stoichiometry: 1.0
species: 305280

639164
type: SpeciesReference
stoichiometry: 1.0
species: 305277

639152
type: SpeciesReference
stoichiometry: 1.0
species: 305283

306041
type: Reaction
reactant: 636569
modifier: 636593
fast: false
product: 636581
modifier: 636617
notes: AP-1: PMID: 2119495 Elk-1: PMID: 9858538 CREB: PMID: 9858538 PMID: 8205620 PMID: 9770464
reversible: false
modifier: 636605

636569
type: SpeciesReference
stoichiometry: 1.0
species: 305015

636581
type: SpeciesReference
stoichiometry: 1.0
species: 305018

306224
type: Reaction
modifier: 639332
product: 639296
notes: GPCR: PMID: 9660746 PMID: 7834744 PMID: 11941304
reactant: 639260
reversible: false
product: 639284
fast: false
modifier: 639320
product: 639308
reactant: 639272

639296
type: SpeciesReference
stoichiometry: 1.0
species: 305277

639260
type: SpeciesReference
stoichiometry: 1.0
species: 305329

639284
type: SpeciesReference
stoichiometry: 1.0
species: 305322

639308
type: SpeciesReference
stoichiometry: 1.0
species: 304694

639272
type: SpeciesReference
stoichiometry: 1.0
species: 304705

306305
type: Reaction
modifier: 640375
product: 640362
reactant: 640349
notes: active ErbB3: PMID: 8026468
fast: false
reversible: false

640362
type: SpeciesReference
stoichiometry: 1.0
species: 305422

640349
type: SpeciesReference
stoichiometry: 1.0
species: 305486

305731
type: Reaction
product: 632806
reactant: 632794
reactant: 632782
notes: PMID: 11252954 PMID: 7834741 PMID: 9708728
fast: false
reversible: false

632806
type: SpeciesReference
stoichiometry: 1.0
species: 304524

632794
type: SpeciesReference
stoichiometry: 1.0
species: 304518

632782
type: SpeciesReference
stoichiometry: 1.0
species: 304521

306088
type: Reaction
modifier: 637145
product: 637133
reactant: 637121
notes: PTEN: PMID: 12829245 PMID: 15276015 PMID: 11395417
fast: false
reversible: false

637133
type: SpeciesReference
stoichiometry: 1.0
species: 305082

637121
type: SpeciesReference
stoichiometry: 1.0
species: 305077

305923
type: Reaction
modifier: 635177
product: 635165
reactant: 635153
notes: PAK1@GTP+Rac/Cdc42: PMID: 11950587 PMID: 10559936
fast: false
reversible: false

635165
type: SpeciesReference
stoichiometry: 1.0
species: 305599

635153
type: SpeciesReference
stoichiometry: 1.0
species: 305561

305825
type: Reaction
reversible: false
fast: false
modifier: 634069
modifier: 634057
reactant: 634008
product: 634032
reactant: 634020
product: 634045
notes: active SOS: PMID: 12006650 PMID: 8479541 PMID: 10740269 GDP-GTP exchange: PMID: 12006650 PMID: 10740269
modifier: 634081

634008
type: SpeciesReference
stoichiometry: 1.0
species: 304710

634032
type: SpeciesReference
stoichiometry: 1.0
species: 304702

634020
type: SpeciesReference
stoichiometry: 1.0
species: 304705

634045
type: SpeciesReference
stoichiometry: 1.0
species: 304694

306429
type: Reaction
modifier: 641865
product: 641853
reactant: 641841
notes: autophosphorylation: PMID: 10455013
fast: false
reversible: false

641853
type: SpeciesReference
stoichiometry: 1.0
species: 305702

641841
type: SpeciesReference
stoichiometry: 1.0
species: 305705

304726
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Rin1

306271
type: Reaction
product: 639921
reactant: 639909
fast: false
reversible: false

639921
type: SpeciesReference
stoichiometry: 1.0
species: 305466

305466
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: cell cycle_br_progression

639909
type: SpeciesReference
stoichiometry: 1.0
species: 305508

306101
type: Reaction
modifier: 637301
product: 637289
reactant: 637277
notes: PI3 PMID: 4 PMID: 5P3: PMID: 12829245 PMID: 15276015
fast: false
reversible: false

637289
type: SpeciesReference
stoichiometry: 1.0
species: 305601

637277
type: SpeciesReference
stoichiometry: 1.0
species: 305611

305972
type: Reaction
modifier: 635777
product: 635765
reactant: 635753
notes: GTP+Ras: PMID: 11023813 PMID: 14663478 PMID: 12006650 PMID: 10740269 PMID: 8503013 PMID: 12446733
fast: false
reversible: false

635765
type: SpeciesReference
stoichiometry: 1.0
species: 305655

635753
type: SpeciesReference
stoichiometry: 1.0
species: 305659

305874
type: Reaction
modifier: 634675
modifier: 634662
product: 634649
reactant: 634636
notes: recycling: PMID: 10816576 SHP1@EGFR.Y1173P: PMID: 9733788 SHP2@EGFR: PMID: 14560030
fast: false
reversible: false

634649
type: SpeciesReference
stoichiometry: 1.0
species: 304518

634636
type: SpeciesReference
stoichiometry: 1.0
species: 304778

305815
type: Reaction
modifier: 633912
modifier: 633900
product: 633888
reactant: 633876
notes: Shc@EGFR.Y1148/1173P: PMID: 14750954 PMID: 12048194
fast: false
reversible: false

633888
type: SpeciesReference
stoichiometry: 1.0
species: 305613

633876
type: SpeciesReference
stoichiometry: 1.0
species: 304672

306352
type: Reaction
product: 640892
reactant: 640880
modifier: 640929
fast: false
product: 640904
reversible: false
modifier: 640916
notes: Cdk2+Cyclin E: PMID: 10499802 PMID: 12459251 PMID: 11960696 Cdk4+Cyclin D: PMID: 12459251 PMID: 11960696 dissociation: PMID: 12459251 PMID: 12459251 PMID: 11960696 PMID: 1828392 PMID: 7596417

640892
type: SpeciesReference
stoichiometry: 1.0
species: 305534

640880
type: SpeciesReference
stoichiometry: 1.0
species: 305538

640904
type: SpeciesReference
stoichiometry: 1.0
species: 305473

305879
type: Reaction
modifier: 634714
product: 634701
reactant: 634688
notes: early end. EGFR: PMID: 12006650
fast: false
reversible: false

634701
type: SpeciesReference
stoichiometry: 1.0
species: 304783

634688
type: SpeciesReference
stoichiometry: 1.0
species: 304574

305991
type: Reaction
modifier: 636005
product: 635993
reactant: 635981
notes: active ERK1: PMID: 12016217 PMID: 10856237 active ERK2: PMID: 12016217 PMID: 10856237
fast: false
reversible: false

635993
type: SpeciesReference
stoichiometry: 1.0
species: 305692

635981
type: SpeciesReference
stoichiometry: 1.0
species: 305690

306357
type: Reaction
modifier: 641001
product: 640989
reactant: 640977
notes: PP2A: PMID: 10995457 PMID: 15276015
fast: false
reversible: false

640989
type: SpeciesReference
stoichiometry: 1.0
species: 305604

640977
type: SpeciesReference
stoichiometry: 1.0
species: 305608

306010
type: Reaction
modifier: 636281
product: 636269
reactant: 636257
notes: phosphorylation: PMID: 8205620 nuc.RSK: PMID: 9528766 PMID: 9770464
fast: false
reversible: false

636269
type: SpeciesReference
stoichiometry: 1.0
species: 304963

636257
type: SpeciesReference
stoichiometry: 1.0
species: 304959

306261
type: Reaction
product: 639849
reactant: 639837
reactant: 639825
notes: PMID: 14607243
fast: false
reversible: false

639849
type: SpeciesReference
stoichiometry: 1.0
species: 305346

639837
type: SpeciesReference
stoichiometry: 1.0
species: 305342

639825
type: SpeciesReference
stoichiometry: 1.0
species: 305164

306312
type: Reaction
modifier: 640448
product: 640436
reactant: 640424
notes: active ErbB3: PMID: 9516479
fast: false
reversible: false

640436
type: SpeciesReference
stoichiometry: 1.0
species: 305429

640424
type: SpeciesReference
stoichiometry: 1.0
species: 305425

305425
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Grb7

306036
type: Reaction
modifier: 636557
product: 636545
reactant: 636533
notes: PP2B: PMID: 10329725
fast: false
reversible: false

636545
type: SpeciesReference
stoichiometry: 1.0
species: 305005

636533
type: SpeciesReference
stoichiometry: 1.0
species: 305008

306117
type: Reaction
modifier: 637481
modifier: 637469
product: 637457
reactant: 637445
notes: active PDK1: PMID: 10021376 PMID: 15209377 DAG: PMID: 9601053
fast: false
reversible: false

637457
type: SpeciesReference
stoichiometry: 1.0
species: 304762

637445
type: SpeciesReference
stoichiometry: 1.0
species: 305105

305913
type: Reaction
product: 635069
reactant: 635057
reactant: 635045
notes: PMID: 11053437
fast: false
reversible: false

635069
type: SpeciesReference
stoichiometry: 1.0
species: 304836

635057
type: SpeciesReference
stoichiometry: 1.0
species: 304833

635045
type: SpeciesReference
stoichiometry: 1.0
species: 304794

305762
type: Reaction
modifier: 633215
product: 633203
reactant: 633191
notes: active EGFR: PMID: 9733788
fast: false
reversible: false

633203
type: SpeciesReference
stoichiometry: 1.0
species: 304589

633191
type: SpeciesReference
stoichiometry: 1.0
species: 304586

304586
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: SHP1

305377
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: S1_sub_2/3

306302
type: Reaction
modifier: 640336
product: 640323
reactant: 640310
notes: active ErbB2: PMID: 7478576
fast: false
reversible: false

640323
type: SpeciesReference
stoichiometry: 1.0
species: 305519

640310
type: SpeciesReference
stoichiometry: 1.0
species: 305481

305443
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: mitogenesis

305843
type: Reaction
product: 634333
reactant: 634321
reactant: 634309
notes: PMID: 11099046
fast: false
reversible: false

634333
type: SpeciesReference
stoichiometry: 1.0
species: 304740

634321
type: SpeciesReference
stoichiometry: 1.0
species: 304609

304609
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Eps8_br_@EGFR.

634309
type: SpeciesReference
stoichiometry: 1.0
species: 304737

306387
type: Reaction
product: 641373
reactant: 641361
notes: degradation: PMID: 7624798 PMID: 15082919 PMID: 9311993
fast: false
reversible: false

641373
type: SpeciesReference
stoichiometry: 1.0
species: 305541

641361
type: SpeciesReference
stoichiometry: 1.0
species: 305584

305584
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: p27

306321
type: Reaction
product: 640544
reactant: 640532
notes: PMID: 9990038
fast: false
reversible: false

640544
type: SpeciesReference
stoichiometry: 1.0
species: 305443

640532
type: SpeciesReference
stoichiometry: 1.0
species: 304682

305418
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Grb2_br_@ErbB2_br_Y1139P

305903
type: Reaction
product: 634973
reactant: 634961
notes: PMID: 11448952 PMID: 15210722
fast: false
reversible: false

634973
type: SpeciesReference
stoichiometry: 1.0
species: 304821

634961
type: SpeciesReference
stoichiometry: 1.0
species: 304815

306415
type: Reaction
product: 641673
reactant: 641661
fast: false
reversible: false

641673
type: SpeciesReference
stoichiometry: 1.0
species: 305046

641661
type: SpeciesReference
stoichiometry: 1.0
species: 305640

306296
type: Reaction
modifier: 640258
product: 640245
reactant: 640232
notes: active ErbB2: PMID: 7478576
fast: false
reversible: false

640245
type: SpeciesReference
stoichiometry: 1.0
species: 305418

640232
type: SpeciesReference
stoichiometry: 1.0
species: 305479

306383
type: Reaction
modifier: 641349
product: 641337
reactant: 641325
notes: Cdk2+Cyclin E: PMID: 9192873 PMID: 15082919
fast: false
reversible: false

641337
type: SpeciesReference
stoichiometry: 1.0
species: 305584

641325
type: SpeciesReference
stoichiometry: 1.0
species: 305581

306005
type: Reaction
modifier: 636197
modifier: 636185
product: 636173
reactant: 636161
notes: active ERK1/2: PMID: 9242373 PMID: 7673108 PMID: 7478566 PMID: 7592690 PMID: 8621459 active RSK: PMID: 9242373
fast: false
reversible: false

636173
type: SpeciesReference
stoichiometry: 1.0
species: 304951

636161
type: SpeciesReference
stoichiometry: 1.0
species: 304577

305890
type: Reaction
modifier: 634841
product: 634829
reactant: 634817
notes: active c-Src: PMID: 12456688 PMID: 15210722 PMID: 11448952 PMID: 11994282
fast: false
reversible: false

634829
type: SpeciesReference
stoichiometry: 1.0
species: 304799

634817
type: SpeciesReference
stoichiometry: 1.0
species: 304791

306158
type: Reaction
modifier: 638094
modifier: 638081
product: 638069
reactant: 638057
notes: GTP+RhoA: PMID: 9013646 PMID: 9395408 PMID: 15150446 PMID: 12401203 active PKC: PMID: 9013646 PMID: 9395408 PMID: 15150446 PMID: 12401203
fast: false
reversible: false

638069
type: SpeciesReference
stoichiometry: 1.0
species: 305177

638057
type: SpeciesReference
stoichiometry: 1.0
species: 305173

305797
type: Reaction
product: 633660
reactant: 633648
reactant: 633636
notes: PMID: 12006650 PMID: 9544989 PMID: 7527043
fast: false
reversible: false

633660
type: SpeciesReference
stoichiometry: 1.0
species: 304635

633648
type: SpeciesReference
stoichiometry: 1.0
species: 304557

633636
type: SpeciesReference
stoichiometry: 1.0
species: 304574

306424
type: Reaction
modifier: 641781
product: 641769
reactant: 641757
notes: unidentified S/T kinase(s): PMID: 12551923
fast: false
reversible: false

641769
type: SpeciesReference
stoichiometry: 1.0
species: 305662

641757
type: SpeciesReference
stoichiometry: 1.0
species: 305665

305850
type: Reaction
notes: hydrolysis: PMID: 14663478 beta2-chimaerin (RacGAP): PMID: 1903516 PMID: 8496137 PMID: 11278894
product: 634441
modifier: 634465
product: 634429
reversible: false
reactant: 634417
modifier: 634453
fast: false

634441
type: SpeciesReference
stoichiometry: 1.0
species: 304713

634429
type: SpeciesReference
stoichiometry: 1.0
species: 304750

634417
type: SpeciesReference
stoichiometry: 1.0
species: 304745

305263
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: LPA_sub_1

306316
type: Reaction
modifier: 640484
product: 640472
reactant: 640460
notes: ErbB4: PMID: 8617750
fast: false
reversible: false

640472
type: SpeciesReference
stoichiometry: 1.0
species: 305439

305439
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Shc_br_@ErbB4_br_Y1188/1242P

640460
type: SpeciesReference
stoichiometry: 1.0
species: 305481

305840
type: Reaction
modifier: 634297
product: 634285
reactant: 634273
notes: GTP+Ras: PMID: 11703925 PMID: 9144171 PMID: 8987396
fast: false
reversible: false

634285
type: SpeciesReference
stoichiometry: 1.0
species: 304730

634273
type: SpeciesReference
stoichiometry: 1.0
species: 304726

304545
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: ADP

305993
type: Reaction
modifier: 636041
product: 636029
reactant: 636017
notes: autophosphorylation: PMID: 10428774 PMID: 10856237
fast: false
reversible: false

636029
type: SpeciesReference
stoichiometry: 1.0
species: 305696

636017
type: SpeciesReference
stoichiometry: 1.0
species: 305692

306127
type: Reaction
modifier: 637637
modifier: 637625
product: 637613
reactant: 637601
notes: active PKA: PMID: 12167631 IP3: PMID: 12167631
fast: false
reversible: false

637613
type: SpeciesReference
stoichiometry: 1.0
species: 305122

637601
type: SpeciesReference
stoichiometry: 1.0
species: 305120

306208
type: Reaction
product: 638996
reactant: 638984
reactant: 638972
notes: PMID: 11875501
fast: false
reversible: false

638996
type: SpeciesReference
stoichiometry: 1.0
species: 305270

638984
type: SpeciesReference
stoichiometry: 1.0
species: 305259

638972
type: SpeciesReference
stoichiometry: 1.0
species: 305263

306031
type: Reaction
modifier: 636485
product: 636473
reactant: 636461
notes: nuc.c-Jun: PMID: 10072388
fast: false
reversible: false

636473
type: SpeciesReference
stoichiometry: 1.0
species: 305003

636461
type: SpeciesReference
stoichiometry: 1.0
species: 304995

306380
type: Reaction
product: 641313
reactant: 641301
fast: false
reversible: false

641313
type: SpeciesReference
stoichiometry: 1.0
species: 305466

641301
type: SpeciesReference
stoichiometry: 1.0
species: 305652

306282
type: Reaction
product: 640066
reactant: 640054
reactant: 640042
notes: PMID: 11185956
fast: false
reversible: false

640066
type: SpeciesReference
stoichiometry: 1.0
species: 305387

640054
type: SpeciesReference
stoichiometry: 1.0
species: 305382

640042
type: SpeciesReference
stoichiometry: 1.0
species: 305377

306193
type: Reaction
modifier: 638695
reversible: false
product: 638647
modifier: 638707
fast: false
modifier: 638671
modifier: 638659
notes: Gbetagamma: PMID: 8245028 PMID: 8387502 PMID: 12790797 Galpha q: PMID: 8245028 PMID: 8387502 PMID: 12790797
reactant: 638635
modifier: 638683

638647
type: SpeciesReference
stoichiometry: 1.0
species: 305236

638635
type: SpeciesReference
stoichiometry: 1.0
species: 305233

306112
type: Reaction
modifier: 637433
modifier: 637421
product: 637409
reactant: 637397
notes: PI3 PMID: 4 PMID: 5P3: PMID: 12829245 PMID: 15276015 autophosphorylation: PMID: 10455013
fast: false
reversible: false

637409
type: SpeciesReference
stoichiometry: 1.0
species: 305702

637397
type: SpeciesReference
stoichiometry: 1.0
species: 305705

306019
type: Reaction
product: 636365
reactant: 636353
fast: false
reversible: false

636365
type: SpeciesReference
stoichiometry: 1.0
species: 304976

636353
type: SpeciesReference
stoichiometry: 1.0
species: 304971

305907
type: Reaction
product: 634997
reactant: 634985
notes: PMID: 11448952 PMID: 15210722
fast: false
reversible: false

634997
type: SpeciesReference
stoichiometry: 1.0
species: 304825

304825
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304506
name: a184_degraded

634985
type: SpeciesReference
stoichiometry: 1.0
species: 304821

306363
type: Reaction
product: 641073
reactant: 641061
reactant: 641049
notes: PMID: 14652114
fast: false
reversible: false

641073
type: SpeciesReference
stoichiometry: 1.0
species: 305595

641061
type: SpeciesReference
stoichiometry: 1.0
species: 305587

641049
type: SpeciesReference
stoichiometry: 1.0
species: 305164

306368
type: Reaction
modifier: 641157
modifier: 641145
product: 641133
reactant: 641121
notes: PP1: PMID: 14652114 PP2A: PMID: 14652114
fast: false
reversible: false

641133
type: SpeciesReference
stoichiometry: 1.0
species: 305595

641121
type: SpeciesReference
stoichiometry: 1.0
species: 305590

306080
type: Reaction
fast: false
modifier: 637037
reversible: false
reactant: 636989
product: 637001
modifier: 637013
modifier: 637025
notes: active c-Myc: PMID: 10920185 PMID: 12565816 active p53: PMID: 8242752 PMID: 11495913 nuc.STAT3: PMID: 14750954

636989
type: SpeciesReference
stoichiometry: 1.0
species: 305059

637001
type: SpeciesReference
stoichiometry: 1.0
species: 305070

306174
type: Reaction
modifier: 638322
product: 638310
reactant: 638298
notes: active PKA: PMID: 15150446
fast: false
reversible: false

638310
type: SpeciesReference
stoichiometry: 1.0
species: 305199

305199
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GTP/RhoA)

638298
type: SpeciesReference
stoichiometry: 1.0
species: 305184

305777
type: Reaction
modifier: 633407
product: 633395
reactant: 633383
notes: active EGFR: PMID: 10648629
fast: false
reversible: false

633395
type: SpeciesReference
stoichiometry: 1.0
species: 305515

633383
type: SpeciesReference
stoichiometry: 1.0
species: 304616

305962
type: Reaction
modifier: 635669
product: 635657
reactant: 635645
notes: MEKK1@GTP+Rac1/Cdc42: PMID: 9305750 PMID: 9312068
fast: false
reversible: false

635657
type: SpeciesReference
stoichiometry: 1.0
species: 304922

635645
type: SpeciesReference
stoichiometry: 1.0
species: 304918

305767
type: Reaction
modifier: 633287
product: 633275
reactant: 633263
notes: active EGFR: PMID: 12127568 PMID: 7532293
fast: false
reversible: false

633275
type: SpeciesReference
stoichiometry: 1.0
species: 304609

633263
type: SpeciesReference
stoichiometry: 1.0
species: 304602

305835
type: Reaction
notes: active RN-tre: PMID: 11099046
product: 634237
modifier: 634261
reactant: 634213
modifier: 634249
reversible: false
product: 634225
fast: false

634237
type: SpeciesReference
stoichiometry: 1.0
species: 304713

634213
type: SpeciesReference
stoichiometry: 1.0
species: 304718

634225
type: SpeciesReference
stoichiometry: 1.0
species: 304722

305737
type: Reaction
modifier: 632914
modifier: 632902
reactant: 632854
product: 632890
product: 632878
notes: autophosphorylation: PMID: 10880430 PMID: 11252954 PMID: 7834741 PMID: 9708728 PMID: 6090945 PMID: 2543678 PMID: 1688559 conformational change: PMID: 10069801 KDI1: PMID: 12842895
fast: false
reactant: 632866
reversible: false

632854
type: SpeciesReference
stoichiometry: 1.0
species: 304527

632890
type: SpeciesReference
stoichiometry: 1.0
species: 304545

632878
type: SpeciesReference
stoichiometry: 1.0
species: 304532

632866
type: SpeciesReference
stoichiometry: 1.0
species: 304538

306215
type: Reaction
product: 639068
product: 639092
modifier: 639104
notes: GPCR: PMID: 9660746 PMID: 7834744 PMID: 11941304 PMID: 12354102
modifier: 639128
product: 639080
modifier: 639116
fast: false
modifier: 639140
reactant: 639056
reactant: 639044
reversible: false

639068
type: SpeciesReference
stoichiometry: 1.0
species: 305277

639092
type: SpeciesReference
stoichiometry: 1.0
species: 304694

639080
type: SpeciesReference
stoichiometry: 1.0
species: 305285

639056
type: SpeciesReference
stoichiometry: 1.0
species: 304705

639044
type: SpeciesReference
stoichiometry: 1.0
species: 305280

306407
type: Reaction
product: 641601
reactant: 641589
notes: PMID: 9287210
fast: false
reversible: false

641601
type: SpeciesReference
stoichiometry: 1.0
species: 305637

641589
type: SpeciesReference
stoichiometry: 1.0
species: 305625

306056
type: Reaction
modifier: 636785
modifier: 636773
product: 636761
reactant: 636749
notes: PP2A: PMID: 15136564 PP2B: PMID: 15136564
fast: false
reversible: false

636761
type: SpeciesReference
stoichiometry: 1.0
species: 305021

636749
type: SpeciesReference
stoichiometry: 1.0
species: 305033