MODEL1304300000
type: SBMLModel
is described by: http://identifiers.org/pubmed/8944170
compartment: metaid cell
name: Hofmeyr1996 - metabolic control analysis
creator:
  ORG:
    orgname: University of Manchester
  n:
    given: Kieran
    family: Smallbone
length unit: length
area units: area
notes: Hofmeyr1996 - metabolic control analysis Understanding of genetic mechanisms would not be possible by studying the properties of individual components. To better understand the system as a whole, it is necessary to study the interaction between components and their response to each other. This paper describes a strategy for the experimental control analysis called co-response analysis. This model is described in the article: Co-response analysis: a new experimental strategy for metabolic control analysis Hofmeyr JH, Cornish-Bowden A Journal of Theoretical Biology [1996, 182(3):371-380] Abstract: The formulation of the standard summation and connectivity relationships as a statement that the matrix of all the elasticities in a system is the inverse of the matrix of all the control coefficients is completely general, provided that only control coefficients for independent fluxes and concentrations are considered, and that the elasticity matrix is written to take account of the stoichiometry of the pathway and the implied dependences between concentrations. This generally implies that co-response analysis is also general, i.e. that all of the elasticities and all of the control coefficients in any system, regardless of branching, feedback effects, moiety conservation or other complications, can be determined by comparing the effects of perturbations of the enzyme activities on the steady-state fluxes and concentrations of the pathway. The approach requires no quantitative information about the magnitudes of the effects on the individual enzyme activities, and consequently no enzymes need to be studied in isolation from the pathway. This model is hosted on BioModels Database and identified by: MODEL1304300000 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been …
modified:
  W3 CDTF: Tue Apr 30 14:53:39 BST 2013
curated: false
created:
  W3 CDTF: Tue Nov 29 00:00:00 GMT 2011

http://identifiers.org/biomodels.db/MODEL1304300000#_0d859b4d_3ffe_420c_8840_63a693c244cf
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS

http://identifiers.org/biomodels.db/MODEL1304300000#f63b3487_5b62_4215_a75b_cec4c52cb8f1
type: Reaction
fast: false
modifier: MODEL1304300000#
reversible: true
is: SBO:0000176
name: v2

http://identifiers.org/biomodels.db/MODEL1304300000#_9a1261d9_8c29_4a12_b0b9_a47f04aad232
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#_263de26f_eedd_44b5_b5de_8a068d0853a7
type: Species
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.5
initial amount: NaN
in compartment: metaid cell
name: s2

metaid cell
type: Compartment
is: GO:0005623
is: SBO:0000290
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

http://identifiers.org/biomodels.db/MODEL1304300000#_70fa85df_740f_465c_9e08_7907803eeb09
type: LocalParameter
units: dimensionless
value: 10.0

http://identifiers.org/biomodels.db/MODEL1304300000#de464b59_ca0d_471c_8c0f_bce32e5d6968
type: LocalParameter
units: dimensionless
value: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#_2f4f65f5_99c9_4fb3_8b99_2f36f61c5b3f
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#cfd9ca2f_6f78_42dd_b23f_7ca06c24ad87
type: Species
is: SBO:0000247
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: metaid cell
name: x7

http://identifiers.org/biomodels.db/MODEL1304300000#f4e486d6_56c5_451c_a9f5_2f44a3c40d8f
type: Species
is: SBO:0000247
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid cell
name: x5

http://identifiers.org/biomodels.db/MODEL1304300000#_76c59007_0594_41bc_b67e_e80ecfe9f7c0
type: Species
is: SBO:0000247
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid cell
name: x4

http://identifiers.org/biomodels.db/MODEL1304300000#c207ea28_8b06_40da_821c_4f64bb88c0b5
type: Species
is: SBO:0000247
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: metaid cell
name: x6

http://identifiers.org/biomodels.db/MODEL1304300000#cde5f915_101b_4f03_915c_9d235f1306be
type: Species
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.5
initial amount: NaN
in compartment: metaid cell
name: s3

http://identifiers.org/biomodels.db/MODEL1304300000#fef41a8d_7555_48f8_9531_65d65c7b4574
type: Species
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid cell
name: s1

http://identifiers.org/biomodels.db/MODEL1304300000#_9a527d96_82e9_4629_b58b_471e41d771ca
type: Species
is: SBO:0000247
constant: true
boundary condition: true
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: metaid cell
name: x0

http://identifiers.org/biomodels.db/MODEL1304300000#_787661d8_427c_40d2_8c26_7c50346e304f
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#c4ee912b_0486_438e_9c0f_8281db8ac85d
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#_9524b9d9_765f_4e32_a6b1_db07732a4057
type: Reaction
is: SBO:0000176
name: v1
modifier: MODEL1304300000#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1304300000#_143cb7f5_cff4_4d02_846a_c560f0aeea6e
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#e1fced69_5f78_4991_a780_9d56421854a3
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#d688e4bc_3718_443d_9bc4_67dde504f72c
type: LocalParameter
units: dimensionless
value: 10.0

http://identifiers.org/biomodels.db/MODEL1304300000#c54ed7ba_18c5_431e_819a_ad6ccf9b3da5
type: LocalParameter
units: dimensionless
value: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#_0dea9bbe_22f9_4370_bb88_6350d2c13b29
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#_739d11a3_efb9_468e_9157_00255c16d2c0
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#_3898b140_e0e0_4986_9568_e9918d3bcd5e
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS

http://identifiers.org/biomodels.db/MODEL1304300000#_4510d8ed_268f_4123_a4d7_9ee927765f40
type: Reaction
modifier: MODEL1304300000#
is: SBO:0000176
fast: false
reversible: true
name: v3

http://identifiers.org/biomodels.db/MODEL1304300000#f599c6bd_f70d_4f23_94b7_d1a40a961949
type: LocalParameter
units: dimensionless
value: 50.0

http://identifiers.org/biomodels.db/MODEL1304300000#_764f411e_2d47_4942_b3ee_4ccbff7321de
type: LocalParameter
units: dimensionless
value: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#_63e7e69d_3e59_43bb_a3a2_57a1ea3e488b
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#e2de9015_4008_41b0_b096_989ede97291e
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#_70c7ceb5_ec96_43bc_9be8_d6db8d568d24
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS

http://identifiers.org/biomodels.db/MODEL1304300000#ebe840e0_a41d_40ac_9876_8d1988b24029
type: Reaction
modifier: MODEL1304300000#
is: SBO:0000176
fast: false
reversible: true
name: v4

http://identifiers.org/biomodels.db/MODEL1304300000#_4602a07b_f550_49b5_b8f8_76b20d7026a0
type: LocalParameter
units: dimensionless
value: 10.0

http://identifiers.org/biomodels.db/MODEL1304300000#_0292edeb_bbbe_41ef_8538_4c953207f0ba
type: LocalParameter
units: dimensionless
value: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#_80d306a8_62e1_4d0e_9ca9_9c562ccadebe
type: SpeciesReference
stoichiometry: 1.0

http://identifiers.org/biomodels.db/MODEL1304300000#a77ba07f_6989_4afa_8021_a16621802f2d
type: SpeciesReference
stoichiometry: 1.0