Cholesterol_ester_palmn __> Cholesterol + Palmitolate
Methacrylyl_CoA <=> 3_Hydroxyisobutyryl_CoA
_R__3_Hydroxydecanoyl_ACP <=> _2E__Decenoyl_ACP
UDP_galactose + Cerd181_180 __> UDP + GalCerd181_180
CoA + Dihomo_gamma_linolenoyl_CoA + FAD + NAD+ __> Acetyl_CoA + FADH2 + gamma_Linolenoyl_CoA + NADH
Cholesterol_ester_gla __> Cholesterol + gamma_Linolenate
PC203_204 __> LPC00_204 + Dihomo_gamma_linolenate
dADP@cyto + adp@mito <=> dADP@mito + adp@cyto
ATP + UTP + Glutamine __> ADP + Glutamate + CTP
14_Demethyllanosterol + 3 NADPH + 3 O2 __> 4alpha_Methylzymosterol_4_carboxylate + 3 NADP+
ATP + gamma_Glutamyl_cysteine + Glycine __> ADP + GSH
NADPH + Glutamyl_5P __> L_Glutamate 5_semialdehyde + NADP+
Docosatetraenoyl_CoA + 1MG204_3P __> DG204_224_P + CoA
_R__3_Hydroxypalmitoyl_ACP <=> _2E__Hexadecenoyl_ACP
GalCerd181_180@cyto <=> GalCerd181_180@micro
Tetracosatetraenoic_acid@ext + atp@cyto __> Tetracosatetraenoic_acid@cyto + adp@cyto
Docosatetraenoic_acid@ext + atp@cyto __> Docosatetraenoic_acid@cyto + adp@cyto
Acetyl_CoA + Glycine <=> CoA + L_2_Amino_acetoacetate
N_Acetylglucosamine_6P <=> N_Acetylglucosamine_1P
ATP + Sphinganine __> ADP + Sphinganine_1P
Docosapentaenoyl_CoA + DG182_202 __> TAG182_202_225 + CoA
UDP_galactose@cyto + UMP@golgi <=> UDP_galactose@golgi + UMP@cyto
Serine + Palmitoyl_CoA __> 3_Dehydrosphinganine + CoA
Deoxyuridine <=> Uracil + 2_Deoxy_D_ribose_1P
3_Hydroxyisobutyryl_CoA __> 3_Hydroxyisobutyrate + CoA
CMP_N_acetylneuraminate + C00237 + NADH __> CMP_NeuNGc + NAD+
ATP + 5_Phosphoribosyl_4_carboxy_5_aminoimidazole + Aspartate __> ADP + SAICAR
Urocanate __> 4_Imidazolone_5_propanoate
Lauroyl_CoA + NADP+ __> _2E__Dodecenoyl_CoA + NADPH
Formylanthranilate <=> Formate + Anthranilate
ATP + Glutamine + Deamido_NAD __> AMP + NAD+ + Glutamate
PC204_224 __> LPC204_00 + Docosatetraenoic_acid
Isovaleryl_CoA + Dihydrolipoamide <=> S__3_Methylbutanoyl__dihydrolipoamide + CoA
2_Oxobutyrate@cyto __> 2_Oxobutyrate@mito
5 CoA + 4 FAD + 5 NAD+ + trans_Octadec_2_enoyl_CoA __> 5 Acetyl_CoA + 4 FADH2 + 5 NADH + Octanoyl_CoA
Cysteate + AKG <=> Glutamate + 3_Sulfopyruvate
PC182_202 __> LPC182_00 + Eicosadienoic_acid
Linoleate + 2 NADPH + Malonyl_CoA __> Eicosadienoic_acid + CoA + 2 NADP+
Palmitoyl_CoA + Cholesterol __> CoA + Cholesterol_ester_palm
168 Alanine + 14 Cysteine + 103 Aspartate + 259 Glutamate + 56 Phenylalanine + 73 Glycine + 36 Histidine + 86 Isoleucine + 206 Lysine + 207 Leucine + 54 Methionine + 95 Asparagine + 29 Proline + 126 Glutamine + 109 Arginine + 96 Serine + 82 Threonine + 86 Valine + 10 Tryptophan + 43 Tyrosine __> Myosin6
Deoxyguanosine <=> Guanine + 2_Deoxy_D_ribose_1P
TAG203_204_226 __> Docosahexaenoic_acid + DG203_204
2_Amino_3_carboxymuconate semialdehyde <=> 2_Aminomuconate semialdehyde
Acetyl_CoA + Putrescine <=> CoA + N_Acetylputrescine
Octanoyl_CoA@peroxy __> Octanoyl_CoA@cyto
Cholesterol_ester_arach __> Cholesterol + Arachidonate
Cholesterol_ester_stea __> Cholesterol + Stearate
stearidonic acid + 2 NADPH + Malonyl_CoA __> Eicosatetraenoic_acid + CoA + 2 NADP+
Cholesterol_ester_stea __> Cholesterol_ester_pool
TAG182_204_205 __> Eicosapentaenoic_acid + DG182_204
NADH + 2 Ferricytochrome b5 __> NAD+ + 2 Ferrocytochrome b5
Eicosapentaenoyl_CoA + DG203_204 __> TAG203_204_205 + CoA
AIR __> 5_Phosphoribosyl_4_carboxy_5_aminoimidazole
Dimethylglycine __> Sarcosine + Formaldehyde
SAM + Guanidinoacetate <=> SAH + Creatine
Phenylalanine@ext <=> Phenylalanine@cyto
ATP + _R__Mevalonate __> ADP + _R__5_Phosphomevalonate
Arachidonate + ATP + CoA __> Arachidonyl_CoA + AMP
Eicosapentaenoic_acid + Cholesterol __> Cholesterol_ester_epa + CoA
2,5_Diaminopyrimidine nucleoside triphosphate
Formamidopyrimidine nucleoside triphosphate
Formamidopyrimidine nucleoside triphosphate <=> 2,5_Diaminopyrimidine nucleoside triphosphate + Formate
Citrate@cyto + Malate@mito <=> Citrate@mito + Malate@cyto
7_Dehydrodesmosterol + NADPH __> Desmosterol + NADP+
3_Phosphoserine + AKG <=> 3_Phosphonooxypyruvate + Glutamate
Hydroxymethylglutathione + NAD+ <=> NADH + Formylglutathione
CDP_diacylglycerol_pool __> CDP_DG182_203
Docosatetraenoyl_CoA + DG203_204 __> TAG203_204_224 + CoA
Dimethylallyl_PP + Isopentenyl_PP __> Geranyl_PP
NADH + 4_Trimethylammoniobutanal __> 4_Trimethylammoniobutanoate + NAD+
CoA + NAD+ + Eicosapentaenoyl_CoA __> Acetyl_CoA + NADH + Stearidonoyl_CoA
3_Oxodecanoyl_ACP + NADPH __> _R__3_Hydroxydecanoyl_ACP + NADP+
_2E__Hexadecenoyl_CoA@cyto __> _2E__Hexadecenoyl_CoA@mito
5alpha_Cholesta_7,24_dien_3beta_ol + NADPH + O2 __> 7_Dehydrodesmosterol + NADP+
Glyceraldehyde + NADPH __> Glycerol + NADP+
Stearate@ext + atp@cyto __> Stearate@cyto + adp@cyto
Presqualene_PP + NADPH __> Squalene + NADP+
Propinol adenylate + CoA <=> AMP + Propanoyl_CoA
4_Aminobutyrate@cyto __> 4_Aminobutyrate@mito
Thioredoxin + UTP __> dUTP + Oxidized thioredoxin
Octanoyl_ACP + Malonyl_ACP __> 3_Oxodecanoyl_ACP + ACP
gamma_Linolenoyl_CoA@cyto + ATP@cyto __> gamma_Linolenoyl_CoA@peroxy + ADP@cyto
5_Methyl_THF + Homocysteine __> THF + Methionine
Sphingosine_1P __> Ethanolamine_P + Hexadecenal
Linolenate + O2 + 2 Ferrocytochrome b5 __> stearidonic acid + 2 Ferricytochrome b5
NADH + L_2_Aminoadipate __> 2_Aminoadipate 6_semialdehyde + NAD+
Dodecanoyl_ACP + Malonyl_ACP __> 3_Oxotetradecanoyl_ACP + ACP
HDL <=> 2 ApoA1 + 90 PC_pool + 30 PS_pool + 20 Cholesterol + 25 PE_pool + 75 SM_pool
UDP_N_acetylglucosamine __> N_Acetyl_D_mannosamine + UDP
Cholesterol_ester_ol __> Cholesterol + Oleate
UDP_glucuronate@cyto __> UDP_glucuronate@endo
Linoleoyl_CoA@cyto <=> Linoleoyl_CoA@micro
7 Alanine + 2 Cysteine + 23 Aspartate + 23 Glutamate + 9 Phenylalanine + 12 Glycine + Histidine + 8 Isoleucine + 13 Lysine + 13 Leucine + 12 Methionine + 5 Asparagine + 2 Proline + 5 Glutamine + 4 Arginine + 5 Serine + 7 Threonine + 8 Valine + Tryptophan + 3 Tyrosine __> TroponinC
Dihomo_gamma_linolenoyl_CoA@cyto __> Dihomo_gamma_linolenoyl_CoA@mito
Glutaryl_CoA + Dihydrolipoamide <=> CoA + S_Glutaryldihydrolipoamide
Hexadecanoyl_ACP + Malonyl_ACP <=> 3_Oxostearoyl_ACP + ACP
decanoic_acid + ATP + CoA __> Decanoyl_CoA + AMP
Docosapentaenoyl_CoA + DG203_204 __> TAG203_204_225 + CoA
D_3_Hydroxydodecanoyl_ACP <=> _2E__Dodecenoyl_ACP
ATP + Fructose_6P __> ADP + Fructose_1,6PP
Arachidonyl_CoA@cyto __> Arachidonyl_CoA@mito
Eicosatetraenoic_acid@cyto <=> Eicosatetraenoic_acid@micro
Docosapentaenoyl_CoA + DG182_204 __> TAG182_204_225 + CoA
ATP + Nicotinate ribonucleotide __> Deamido_NAD
ATP + Ethanolamine __> ADP + Ethanolamine_P
Thioredoxin + CTP __> dCTP + Oxidized thioredoxin
8Z_11Z_14Z_17Z_eicosatetraenoyl_CoA + 1MG182_3P __> DG182_204_P + CoA
Cholesterol_ester_laur __> Cholesterol_ester_pool
N_Acetylneuraminate <=> N_Acetyl_D_mannosamine + Pyruvate
CoA + 8Z_11Z_14Z_17Z_eicosatetraenoyl_CoA + FAD + NAD+ __> Acetyl_CoA + FADH2 + NADH + Stearidonoyl_CoA
Deoxycytidine@ext __> Deoxycytidine@cyto
Arachidonoyl_CoA + 1MG182_3P __> DG182_202_P + CoA
Oxidized thioredoxin + NADPH __> Thioredoxin + NADP+
SAM + Phosphodimethylethanolamine __> SAH + Phosphocholine
Dihomo_gamma_linolenoyl_CoA + 1MG182_3P __> DG182_203_P + CoA
PC182_204 __> LPC182_00 + Eicosatetraenoic_acid
DG182_202 + CDP_ethanolamine __> PE182_202 + CMP
AKG + L_erythro_4_Hydroxyglutamate <=> D_4_Hydroxy_2_oxoglutarate + Glutamate
2 O2 + 2 1_Methylnicotinamide __> N1_Methyl_2_pyridone_5_carboxamide + 2 H2O2 + N1_Methyl_4_pyridone_5_carboxamide
Cholesterol_ester_gla __> Cholesterol_ester_pool
Cholesterol_ester_epa __> Cholesterol_ester_pool
Arginine + 2 O2 + NADPH __> Citrulline + NADP+
lauric_acid@ext + atp@cyto __> lauric_acid@cyto + adp@cyto
SM_d181_160 __> Cerd181_160 + Phosphocholine
Tetracosapentaenoic_acid@ext + atp@cyto __> Tetracosapentaenoic_acid@cyto + adp@cyto
Ethanolamine_P + CTP <=> CDP_ethanolamine
5_Methylthioadenosine __> Methylthioribose_1P + Adenine
Docosatetraenoyl_CoA + DG180_181 __> TAG180_181_224 + CoA
Fumarate + Acetoacetate <=> Fumarylacetoacetate
Glycogenin_G7G1 __> Glycogenin_G7 + Glucose
Serine + Pyruvate <=> Hydroxypyruvate + Alanine
Linolenoyl_CoA@cyto __> Linolenoyl_CoA@mito
Isocitrate + NADP+ __> Oxalosuccinate + NADPH
2239 Alanine + 514 Cysteine + 1732 Aspartate + 3358 Glutamate + 901 Phenylalanine + 2081 Glycine + 466 Histidine + 2033 Isoleucine + 3038 Lysine + 2130 Leucine + 423 Methionine + 1105 Asparagine + 2709 Proline + 971 Glutamine + 1666 Arginine + 2489 Serine + 2621 Threonine + 3265 Valine + 469 Tryptophan + 1003 Tyrosine __> Titin
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH
gamma_Linolenate + 2 NADPH + Malonyl_CoA __> Dihomo_gamma_linolenate + CoA + 2 NADP+
Hydroxypyruvate + NADPH __> Glycerate + NADP+
dUMP + 5,10_Methylene_THF __> Dihydrofolate + dTMP
Butyryl_ACP + Malonyl_ACP __> ACP + 3_Oxohexanoyl_ACP
GTP __> 6_[_1S,2R__1,2_Dihydroxy_3_triphosphooxypropyl]_7,8_dihydropterin + Formate
Glutamine + Pyruvate <=> 2_Oxoglutaramate + Alanine
TAG182_203_204 __> Eicosatetraenoic_acid + DG182_203
Eicosapentaenoic_acid + ATP + CoA __> Eicosapentaenoyl_CoA + AMP
4,4_Dimethyl_5alpha_cholesta_8,14,24_trien_3beta_ol + NADPH __> 14_Demethyllanosterol + NADP+
Docosatetraenoyl_CoA + DG182_202 __> TAG182_202_224 + CoA
Eicosapentaenoyl_CoA + DG180_181 __> TAG180_181_205 + CoA
2 ATP + Glutamine __> 2 ADP + Glutamate + Carbamoyl_P
Arachidonyl_CoA + Cholesterol __> CoA + Cholesterol_ester_arach
Octanoate@ext + atp@cyto __> Octanoate@cyto + adp@cyto
2_Aminomuconate semialdehyde + NAD+ __> 2_Aminomuconate + NADH
AKG + L_2_Aminoadipate <=> 2_Oxoadipate + Glutamate
Betaine + Homocysteine __> Dimethylglycine + Methionine
PE203_204 + Serine __> PS203_204 + Ethanolamine
2_Oxoadipate + Lipoamide __> S_Glutaryldihydrolipoamide
ATP + Pantothenate __> ADP + D_4_Phosphopantothenate
Lignocerate@ext + atp@cyto __> Lignocerate@cyto + adp@cyto
Pyruvate + CoA + NAD+ __> Acetyl_CoA + NADH
VLDL __> 7 ApoE + 10385 Triacylglycerol_pool + 2165 PC_pool + 1645 Cholesterol_ester_pool + PI_pool + 165 2_Lysolecithin_pool + 185 PE_pool + ApoB100 + 500 Cholesterol + 755 SM_pool
Butyrate@ext + atp@cyto __> Butyrate@cyto + adp@cyto
2_Oxo_3_methylvalerate + Lipoamide __> S__2_Methylbutanoyl__dihydrolipoamide
TAG203_204_204 __> Eicosatetraenoic_acid + DG203_204
Stearoyl_CoA + sn_Glycerol_3P __> CoA + 1MG180_3P
Linoleoyl_CoA + 1MG204_3P __> DG204_182_P + CoA
SAM + N_Methylethanolamine_P <=> SAH + Phosphodimethylethanolamine
TAG182_202_203 __> Dihomo_gamma_linolenate + DG182_202
3_Hydroxyanthranilate + O2 __> 2_Amino_3_carboxymuconate semialdehyde
Eicosadienoic_acid + ATP + CoA __> Arachidonoyl_CoA + AMP
Isobutyryl_CoA + FAD __> Methacrylyl_CoA + FADH2
Thymine + NADPH __> Dihydrothymine + NADP+
NADPH + _2E__Hexenoyl_ACP __> Hexanoyl_ACP + NADP+
2 CoA + Docosapentaenoyl_CoA + 2 NAD+ __> 2 Acetyl_CoA + gamma_Linolenoyl_CoA + 2 NADH
DG204_224 + CDP_ethanolamine __> PE204_224 + CMP
D_3_Amino_isobutanoate + AKG <=> 2_Methyl_3_oxopropanoate + Glutamate
Cholesterol_ester_epa __> Cholesterol + Eicosapentaenoic_acid
TAG180_181_204 __> Eicosatetraenoic_acid + DG180_181
ATP + Glutamate + NH3 __> ADP + Glutamine
Eicosapentaenoyl_CoA + DG182_204 __> TAG182_204_205 + CoA
CoA + NAD+ + 3_Oxopropanoate __> Acetyl_CoA + NADH
7 CoA + 7 FAD + 7 NAD+ + Palmitoyl_CoA __> 8 Acetyl_CoA + 7 FADH2 + 7 NADH
Glucosamine_6P + Acetyl_CoA __> CoA + N_Acetylglucosamine_6P
L_Glutamate 5_semialdehyde <=> 1_Pyrroline_5_carboxylate
decanoic_acid@ext + atp@cyto __> decanoic_acid@cyto + adp@cyto
Oleoyl_CoA + Cholesterol __> CoA + Cholesterol_ester_ol
dITP@cyto + ATP@mito __> dITP@mito + ATP@cyto
Acetyl_CoA + Acetoacetyl_CoA __> HMG_CoA + CoA
Uracil + NADPH __> 5,6_Dihydrouracil + NADP+
TAG203_204_205 __> Eicosapentaenoic_acid + DG203_204
DG160_161 + CDP_ethanolamine __> PE160_161 + CMP
Deamido_NAD __> AMP + Nicotinate ribonucleotide
L_Cystathionine __> Cysteine + NH3 + 2_Oxobutyrate
Propanoate@ext + atp@cyto __> Propanoate@cyto + adp@cyto
PEP + N_Acetylmannosamine_6P __> N_Acetylneuraminate_9P
Quinolinate + PRPP __> Nicotinate ribonucleotide
D_3_Amino_isobutanoate@cyto __> D_3_Amino_isobutanoate@mito
CoA + Docosapentaenoyl_CoA + NAD+ + O2 __> Acetyl_CoA + NADH + Eicosapentaenoyl_CoA
TAG160_161_205 __> Eicosapentaenoic_acid + DG160_161
stearidonic acid@ext + atp@cyto __> stearidonic acid@cyto + adp@cyto
CoA + NAD+ + O2 + Tetracosapentaenoyl_CoA __> Acetyl_CoA + Docosapentaenoyl_CoA + NADH
3 CoA + 3 FAD + 3 NAD+ + Octanoyl_CoA __> 4 Acetyl_CoA + 3 FADH2 + 3 NADH
dTTP@cyto + ATP@mito __> dTTP@mito + ATP@cyto
4__2_Amino_3_hydroxyphenyl__2,4_dioxobutanoate <=> Xanthurenate
GlcCerd181_180@cyto <=> GlcCerd181_180@lyso
29 Alanine + 6 Cysteine + 22 Aspartate + 28 Glutamate + 12 Phenylalanine + 28 Glycine + 9 Histidine + 30 Isoleucine + 19 Lysine + 27 Leucine + 16 Methionine + 12 Asparagine + 19 Proline + 11 Glutamine + 18 Arginine + 24 Serine + 26 Threonine + 21 Valine + 4 Tryptophan + 16 Tyrosine __> Actin
Dihomo_gamma_linolenate@cyto <=> Dihomo_gamma_linolenate@micro
Glyoxylate + NADPH __> Glycolate + NADP+
Glutamate + 5_Formyl_THF <=> THF + N_Formyl_L_glutamate
PE182_203 + Serine __> PS182_203 + Ethanolamine
Acetyl adenylate + CoA <=> AMP + Acetyl_CoA
trans_Octadec_2_enoyl_CoA@cyto __> trans_Octadec_2_enoyl_CoA@mito
Thioredoxin + GTP __> dGTP + Oxidized thioredoxin
Tyrosine + AKG <=> 4_Hydroxyphenylpyruvate + Glutamate
Deoxyguanosine@ext __> Deoxyguanosine@cyto
Propanoyl_CoA + NADH __> 2_Methyl_3_oxopropanoate + CoA + NAD+
GDP_mannose __> GDP_4_dehydro_6_deoxy_D_mannose
Zymosterol + NADPH __> Cholestenol + NADP+
Glucose_6P + NADP+ __> NADPH + Glucono_1,5_lactone_6P
Docosatetraenoic_acid + ATP + CoA __> Docosatetraenoyl_CoA + AMP
3_Dehydrosphinganine + NADPH __> Sphinganine + NADP+
_2E__Hexadecenoyl_CoA + NADPH __> Palmitoyl_CoA + NADP+
4_Methyl_2_oxopentanoate + Lipoamide __> S__3_Methylbutanoyl__dihydrolipoamide
Cholesterol_ester_palmn __> Cholesterol_ester_pool
GTP + IMP + Aspartate __> GDP + Adenylosuccinate
gamma_Linolenate + ATP + CoA __> gamma_Linolenoyl_CoA + AMP
LDL __> 1515 Cholesterol_ester_pool + ApoB100 + 680 Cholesterol + 110 CDP_diacylglycerol_pool + 425 PC_pool + 25 2_Lysolecithin_pool + 160 SM_pool + 30 PE_pool
ADP@endo + ATP@cyto __> ADP@cyto + ATP@endo
Thioredoxin + ATP __> dATP + Oxidized thioredoxin
4_Methyl_2_oxopentanoate + CoA + NAD+ __> Isovaleryl_CoA + NADH
dATP@cyto + ATP@mito __> dATP@mito + ATP@cyto
14_Demethyllanosterol + 6 O2 + 6 NADPH __> Zymosterol + 6 NADP+
SM_d181_180 __> Cerd181_180 + Phosphocholine
Cholesterol_ester_lin __> Cholesterol + Linoleate
PE204_224 + Serine __> PS204_224 + Ethanolamine
PE225_226 + Serine __> PS225_226 + Ethanolamine
Arachidonyl_CoA + sn_Glycerol_3P __> CoA + 1MG204_3P
156 Alanine + 19 Cysteine + 103 Aspartate + 258 Glutamate + 61 Phenylalanine + 64 Glycine + 39 Histidine + 85 Isoleucine + 207 Lysine + 220 Leucine + 36 Methionine + 74 Asparagine + 30 Proline + 125 Glutamine + 108 Arginine + 108 Serine + 105 Threonine + 91 Valine + 9 Tryptophan + 42 Tyrosine __> Myosin3
Spermine + Acetyl_CoA __> CoA + N_Acetylspermine
_S__3_Hydroxy_2_methylbutyryl_CoA <=> Tiglyl_CoA
PC182_203 __> LPC182_00 + Dihomo_gamma_linolenate
Palmitoyl_CoA + sn_Glycerol_3P __> CoA + 1MG160_3P
O2 + Pyridoxamine __> Pyridoxal + H2O2 + NH3
4_Aminobutanal + NADP+ __> 4_Aminobutyrate + NADPH
Propanoyl_CoA@cyto __> Propanoyl_CoA@mito
3_Ureidoisobutyrate __> D_3_Amino_isobutanoate + NH3
Linoleate@ext + atp@cyto __> Linoleate@cyto + adp@cyto
gamma_Linolenate@lyso __> gamma_Linolenate@cyto
TAG180_181_205 __> Eicosapentaenoic_acid + DG180_181
Tetracosatetraenoyl_CoA@cyto + ATP@cyto __> Tetracosatetraenoyl_CoA@peroxy + ADP@cyto
Sphinganine + Palmitoyl_CoA __> Cerd180_160 + CoA
3_Keto_4_methylzymosterol + NADP+ <=> NADPH + 4alpha_Methylzymosterol
3PG + NAD+ __> 3_Phosphonooxypyruvate + NADH
ADP@cyto + ATP@mito __> ADP@mito + ATP@cyto
Tetrahydrobiopterin + Phenylalanine + O2 __> Dihydrobiopterin + Tyrosine
dUDP@cyto + adp@mito <=> dUDP@mito + adp@cyto
PE182_202 + Serine __> PS182_202 + Ethanolamine
TAG182_203_203 __> Dihomo_gamma_linolenate + DG182_203
Eicosapentaenoyl_CoA@cyto __> Eicosapentaenoyl_CoA@mito
beta_Alanine + AKG <=> Glutamate + 3_Oxopropanoate
Palmitate + ATP + CoA __> Palmitoyl_CoA + AMP
8Z_11Z_14Z_17Z_eicosatetraenoyl_CoA + 1MG203_3P __> DG203_204_P + CoA
Eicosadienoic_acid + O2 + 2 Ferrocytochrome b5 __> Dihomo_gamma_linolenate + 2 Ferricytochrome b5
Docosatetraenoyl_CoA + CoA + FAD + NAD+ __> Acetyl_CoA + Arachidonyl_CoA + FADH2 + NADH
TAG225_226_226 __> Docosahexaenoic_acid + DG225_226
GTP + Succinate + CoA __> GDP + Succinyl_CoA
gamma_Linolenoyl_CoA + DG180_181 __> TAG180_181_183 + CoA
Linoleoyl_CoA + sn_Glycerol_3P __> CoA + 1MG182_3P
ATP + Glutamine + Aspartate __> AMP + Glutamate + Asparagine
3_Ureidopropionate __> beta_Alanine + NH3
UDP_glucose + Cerd181_160 __> UDP + GlcCerd181_160
6 CoA + 6 FAD + 6 NAD+ + Myristoyl_CoA __> 7 Acetyl_CoA + 6 FADH2 + 6 NADH
AKG + Phenylalanine <=> Phenylpyruvate + Glutamate
GlcCerd181_180 __> Glucose + Cerd181_180
Phosphocreatine@mito __> Phosphocreatine@cyto
_S__Dihydroorotate <=> N_Carbamoyl_L_aspartate
Arachidonyl_CoA@cyto + ATP@cyto __> Arachidonyl_CoA@peroxy + ADP@cyto
Lauroyl_CoA + Cholesterol __> Cholesterol_ester_laur + CoA
Docosahexaenoyl_CoA + DG180_181 __> TAG180_181_226 + CoA
ATP + _R__5_Diphosphomevalonate __> Isopentenyl_PP + ADP
3_Hydroxystearoyl_ACP <=> _2E__Octadecenoyl_ACP
Palmitate + 2 NADPH + Malonyl_CoA __> CoA + 2 NADP+ + Stearate
Cholesterol + O2 + NADPH __> 7alpha_Hydroxycholesterol + NADP+
5 CoA + 2 FAD + Linolenoyl_CoA + 5 NAD+ __> 5 Acetyl_CoA + 2 FADH2 + 5 NADH + Octanoyl_CoA
AKG + Ornithine <=> L_Glutamate 5_semialdehyde + Glutamate
SAM + Histamine <=> SAH + N_Methylhistamine
D_4_Phosphopantothenate + Cysteine + CTP __> CMP + _R__4_Phosphopantothenoyl_cysteine
ATP + Glutamate + Cysteine __> ADP + gamma_Glutamyl_cysteine
5,10_Methylene_THF + NADH __> 5_Methyl_THF + NAD+
gamma_Glutamyl_cysteine __> Cysteine + 5_Oxoproline
ATP + Propanoyl_CoA __> ADP + Methylmalonyl_CoA
ATP + CoA + Acetoacetate __> AMP + Acetoacetyl_CoA
DG182_204 + CDP_ethanolamine __> PE182_204 + CMP
2_Deoxy_D_ribose_1P <=> 2_Deoxy_D_ribose_5P
Cholesterol_ester_palm __> Cholesterol + Palmitate
Succinate semialdehyde + NADP+ __> Succinate + NADPH
Docosahexaenoyl_CoA + DG182_204 __> TAG182_204_226 + CoA
ATP + Acetate + CoA __> AMP + Acetyl_CoA
Docosahexaenoyl_CoA + DG203_204 __> TAG203_204_226 + CoA
Sedoheptulose_7P + GAP <=> Fructose_6P + Erythrose_4P
dGDP@cyto + adp@mito <=> dGDP@mito + adp@cyto
GlcCerd181_180@cyto <=> GlcCerd181_180@micro
NADPH + Desmosterol __> Cholesterol + NADP+
Thioredoxin + UDP __> dUDP + Oxidized thioredoxin
CoA + FAD + NAD+ + Butyryl_CoA __> 2 Acetyl_CoA + FADH2 + NADH
Arachidonate@cyto <=> Arachidonate@micro
Malonyl_ACP + Hexanoyl_ACP __> 3_Oxooctanoyl_ACP + ACP
Sphingosine + ATP __> Sphingosine_1P + ADP
Sedoheptulose_7P + Thiamin_PP <=> 2__1,2_Dihydroxyethyl__TPP + Ribose_5P
ATP + Creatine __> ADP + Phosphocreatine
Tryptamine + O2 __> Indole_acetaldehyde + H2O2 + NH3
dCDP@cyto + adp@mito <=> dCDP@mito + adp@cyto
Isoleucine + AKG <=> Glutamate + 2_Oxo_3_methylvalerate
_Hydroxymethylphenyl_succinyl_CoA + NAD+ <=> NADH + Benzoylsuccinyl_CoA
DG203_204 + CDP_ethanolamine __> PE203_204 + CMP
Acetoacetate@cyto __> Acetoacetate@peroxy
Palmitoyl_CoA@cyto + ATP@cyto __> Palmitoyl_CoA@peroxy + ADP@cyto
gamma_Linolenoyl_CoA + 1MG182_3P __> DG182_183_P + CoA
_2E__Hexadecenoyl_CoA + Cholesterol __> CoA + Cholesterol_ester_palmn
2 CoA + 2 FAD + 2 NAD+ + Hexanoyl_CoA __> 3 Acetyl_CoA + 2 FADH2 + 2 NADH
Deoxythymidine <=> Thymine + 2_Deoxy_D_ribose_1P
Elaidate + ATP + CoA __> trans_Octadec_2_enoyl_CoA + AMP
TAG160_161_226 __> Docosahexaenoic_acid + DG160_161
2,5_Diamino_6__5_triphosphoryl_3,4_trihydroxy_2_oxopentyl__ amino_4_oxopyrimidine
6_[_1S,2R__1,2_Dihydroxy_3_triphosphooxypropyl]_7,8_dihydropterin __> 2,5_Diamino_6__5_triphosphoryl_3,4_trihydroxy_2_oxopentyl__ amino_4_oxopyrimidine
Docosatetraenoic_acid + O2 + 2 Ferrocytochrome b5 __> Tetracosapentaenoic_acid + 2 Ferricytochrome b5
Docosahexaenoyl_CoA + 10 CoA + 4 FAD + 10 NAD+ __> 11 Acetyl_CoA + 4 FADH2 + 10 NADH
TAG182_203_224 __> Docosatetraenoic_acid + DG182_203
2 Succinate + O2 + 4 ADP __> 2 Fumarate + 4 ATP
Docosapentaenoyl_CoA@cyto __> Docosapentaenoyl_CoA@mito
Lignoceroyl_CoA@cyto + ATP@cyto __> Lignoceroyl_CoA@peroxy + ADP@cyto
CoA + FAD + NAD+ + Stearoyl_CoA __> Acetyl_CoA + FADH2 + NADH + Palmitoyl_CoA
SAM + Protein N6,N6_dimethyl_L_lysine __> SAH + Protein N6,N6,N6_trimethyl_L_lysine
Stearoyl_CoA@cyto + ATP@cyto __> Stearoyl_CoA@peroxy + ADP@cyto
5,10_Methylene_THF + NADPH __> 5_Methyl_THF + NADP+
N_Acetylglucosamine@cyto __> N_Acetylglucosamine@micro
Dihomo_gamma_linolenate@lyso __> Dihomo_gamma_linolenate@cyto
Hydracrylate + NAD+ __> NADH + 3_Oxopropanoate
Tetracosapentaenoyl_CoA@cyto + ATP@cyto __> Tetracosapentaenoyl_CoA@peroxy + ADP@cyto
Eicosapentaenoic_acid@ext + atp@cyto __> Eicosapentaenoic_acid@cyto + adp@cyto
Stearidonoyl_CoA@cyto __> Stearidonoyl_CoA@mito
stearidonic acid@lyso __> stearidonic acid@cyto
3_Hydroxy_L_kynurenine __> 3_Hydroxyanthranilate + Alanine
Cholesterol_ester_myr __> Cholesterol_ester_pool
Glutamine + Fructose_6P __> Glutamate + Glucosamine_6P
Docosahexaenoyl_CoA + DG182_202 __> TAG182_202_226 + CoA
_R__3_Hydroxyoctanoyl_ACP <=> _2E__Octenoyl_ACP
gamma_Linolenate@ext + atp@cyto __> gamma_Linolenate@cyto + adp@cyto
Cholesterol_ester_ala __> Cholesterol + Linolenate
4 CoA + 3 FAD + 4 NAD+ + _2E__Hexadecenoyl_CoA __> 4 Acetyl_CoA + 3 FADH2 + 4 NADH + Octanoyl_CoA
HMG_CoA + 2 NADPH __> _R__Mevalonate + CoA + 2 NADP+
NADPH + 6_Pyruvoyltetrahydropterin __> 6_Lactoyl_5,6,7,8_tetrahydropterin + NADP+
Dihomo_gamma_linolenoyl_ACP __> Stearate + Dihomo_gamma_linolenate
2_Deoxy_D_ribose_5P + ADP <=> Thyminose + ATP
Citrate@cyto + Succinate@mito __> Citrate@mito + Succinate@cyto
TAG182_202_204 __> Eicosatetraenoic_acid + DG182_202
Homocarnosine <=> 4_Aminobutyrate + Histidine
TAG160_161_204 __> Eicosatetraenoic_acid + DG160_161
Glutamate@cyto + Aspartate@mito __> Glutamate@mito + Aspartate@cyto
GalCerd181_160@cyto <=> GalCerd181_160@micro
Thioredoxin + ADP __> dADP + Oxidized thioredoxin
GSH@cyto + atp@cyto __> GSH@ext + adp@cyto
Protein N6,N6,N6_trimethyl_L_lysine __> N6,N6,N6_Trimethyl_L_lysine
Dihomo_gamma_linolenoyl_CoA + DG182_203 __> TAG182_203_203 + CoA
CDP_diacylglycerol_pool __> CDP_DG204_222
6_Phospho_D_gluconate + NADP+ __> NADPH + Ribulose_5P
L_Glutamate 5_semialdehyde + NAD+ __> Glutamate + NADH
34 Alanine + 2 Cysteine + 22 Aspartate + 59 Glutamate + Phenylalanine + 4 Glycine + Histidine + 11 Isoleucine + 39 Lysine + 29 Leucine + 8 Methionine + 7 Asparagine + 16 Glutamine + 14 Arginine + 12 Serine + 8 Threonine + 11 Valine + 6 Tyrosine __> Tropomyosin_beta_chain
Eicosadienoic_acid@cyto <=> Eicosadienoic_acid@micro
Linoleoyl_CoA@cyto __> Linoleoyl_CoA@mito
36 Alanine + Cysteine + 24 Aspartate + 56 Glutamate + Phenylalanine + 3 Glycine + 2 Histidine + 12 Isoleucine + 39 Lysine + 33 Leucine + 6 Methionine + 5 Asparagine + Proline + 14 Glutamine + 14 Arginine + 15 Serine + 8 Threonine + 9 Valine + Tryptophan + 6 Tyrosine __> Tropomyosin_alpha1_chain
Dihomo_gamma_linolenate + O2 + 2 Ferrocytochrome b5 __> Arachidonate + 2 Ferricytochrome b5
ATP + Phosphopantetheine __> Dephospho_CoA
Glycine + O2 __> Glyoxylate + H2O2 + NH3
Palmitoyl_CoA@cyto __> Palmitoyl_CoA@mito
GalCerd181_180@cyto <=> GalCerd181_180@lyso
AKG + CoA + NAD+ __> NADH + Succinyl_CoA
TAG203_204_224 __> Docosatetraenoic_acid + DG203_204
Dihydrobiopterin + NADPH __> Tetrahydrobiopterin + NADP+
Thioredoxin + GDP __> dGDP + Oxidized thioredoxin
Succinyl_CoA + Acetoacetate __> Succinate + Acetoacetyl_CoA
4 CoA + 4 FAD + 4 NAD+ + Decanoyl_CoA __> 5 Acetyl_CoA + 4 FADH2 + 4 NADH
_R__3_Hydroxybutanoate@ext __> _R__3_Hydroxybutanoate@cyto
N_Acetylspermidine + O2 __> Putrescine + H2O2 + Aminopropionaldehyde
DG180_181 + CDP_ethanolamine __> PE180_181 + CMP
1MG160_3P + _2E__Hexadecenoyl_CoA __> DG160_161_P + CoA
O2 + Pyridoxine_P __> H2O2 + Pyridoxal_P
decanoic_acid@lyso __> decanoic_acid@cyto
sn_Glycerol_3P@cyto <=> sn_Glycerol_3P@peroxy
Myristoyl_CoA + Cholesterol __> Cholesterol_ester_myr + CoA
Dihydrobiopterin + NADH __> Tetrahydrobiopterin + NAD+
Karlstaedt2012 - CardioNet, A Human Metabolic Network
Cysteine + AKG <=> Mercaptopyruvate + Glutamate
AKG + O2 + N6,N6,N6_Trimethyl_L_lysine __> 3_Hydroxy_N6,N6,N6_trimethyl_L_lysine + Succinate
Cholesterol_ester_dihomogla __> Cholesterol + Dihomo_gamma_linolenate
4_Imidazolone_5_propanoate __> N_Formimino_L_glutamate
Docosahexaenoyl_CoA + DG225_226 __> TAG225_226_226 + CoA
Cholesterol_ester_dihomogla __> Cholesterol_ester_pool
Cholesterol + Linoleoyl_CoA __> CoA + Cholesterol_ester_lin
SAM + Protein N6_methyl_L_lysine __> SAH + Protein N6,N6_dimethyl_L_lysine
UDP_galactose + Cerd181_160 __> UDP + GalCerd181_160
Cholesterol_ester_palm __> Cholesterol_ester_pool
Isopentenyl_PP + Geranyl_PP __> Farnesyl_PP
Glutamate + 5_Formiminotetrahydrofolate <=> THF + N_Formimino_L_glutamate
Kynurenine + AKG <=> Glutamate + 4__2_Aminophenyl__2,4_dioxobutanoate
NAD+ + _R__3_Hydroxybutanoate <=> NADH + Acetoacetate
Linolenate@ext + atp@cyto __> Linolenate@cyto + adp@cyto
23 Alanine + Cysteine + 17 Aspartate + 69 Glutamate + 6 Phenylalanine + 11 Glycine + 5 Histidine + 12 Isoleucine + 34 Lysine + 17 Leucine + 4 Methionine + 14 Asparagine + 10 Proline + 16 Glutamine + 30 Arginine + 8 Serine + 7 Threonine + 12 Valine + 3 Tryptophan + 3 Tyrosine __> TroponinT
Glycogenin + 8 UDP_glucose __> 8 UDP + Glycogenin_G8
dUTP@cyto + ATP@mito __> dUTP@mito + ATP@cyto
Eicosapentaenoyl_CoA@cyto + ATP@cyto __> Eicosapentaenoyl_CoA@peroxy + ADP@cyto
Phenylalanine@cyto <=> Phenylalanine@mito
Palmitoyl_CoA + O2 + 2 Ferrocytochrome b5 __> _2E__Hexadecenoyl_CoA + 2 Ferricytochrome b5
DG182_203 + CDP_ethanolamine __> PE182_203 + CMP
Glyceraldehyde + NAD+ __> Glycerate + NADH
_S__Dihydroorotate@cyto __> _S__Dihydroorotate@mito
Arginine + Glycine <=> Guanidinoacetate + Ornithine
TAG182_202_226 __> Docosahexaenoic_acid + DG182_202
cystine_L@ext + glu_L@cyto <=> cystine_L@cyto + glu_L@ext
Arachidonate + 2 NADPH + Malonyl_CoA __> CoA + 2 NADP+ + Docosatetraenoic_acid
Docosahexaenoic_acid + ATP + CoA __> Docosahexaenoyl_CoA + AMP
But_2_enoyl_ACP + NADPH __> Butyryl_ACP + NADP+
Isobutyryl_CoA + Dihydrolipoamide <=> CoA + S__2_Methylpropanoyl__dihydrolipoamide
N__omega__Hydroxyarginine + O2 __> Citrulline
UDP_glucose + Galactose_1P __> Glucose_1P + UDP_galactose
Deoxyguanosine@cyto <=> Deoxyguanosine@mito
lauric_acid + ATP + CoA __> Lauroyl_CoA + AMP
Nicotinate D_ribonucleoside <=> Nicotinate + Ribose_1P
AKG + NADPH + Lysine __> Saccharopine + NADP+
TAG182_202_224 __> Docosatetraenoic_acid + DG182_202
CDP_diacylglycerol_pool __> CDP_DG180_181
stearidonic acid@cyto <=> stearidonic acid@micro
AKG@cyto + Malate@mito __> AKG@mito + Malate@cyto
GlcCerd181_160 __> Glucose + Cerd181_160
Dihomo_gamma_linolenoyl_CoA + DG160_161 __> TAG160_161_203 + CoA
gamma_Linolenate@cyto <=> gamma_Linolenate@micro
Karlstaedt2012 - CardioNet, A Human Metabolic Network CardioNet is a functionally validated metabolic network of the human cardiomyocyte that enables theorectical studies of cellular metabolic processes. This model is described in the article: CardioNet: A human metabolic network suited for the study of cardiomyocyte metabolism. Karlstaedt A, Fliegner D, Kararigas G, Ruderisch HS, Regitz-Zagrosek V, Holzhütter HG. BMC Syst Biol. 2012 Aug 29;6(1):114. Abstract: BACKGROUND: Availability of oxygen and nutrients in the coronary circulation is a crucial determinant of cardiac performance. Nutrient composition of coronary blood may significantly vary in specific physiological and pathological conditions, for example, administration of special diets, long-term starvation, physical exercise or diabetes. Quantitative analysis of cardiac metabolism from a systems biology perspective may help to a better understanding of the relationship between nutrient supply and efficiency of metabolic processes required for an adequate cardiac output. RESULTS: Here we present CardioNet, the first large-scale reconstruction of the metabolic network of the human cardiomyocyte comprising 1793 metabolic reactions, including 560 transport processes in six compartments. We use flux-balance analysis to demonstrate the capability of the network to accomplish a set of 368 metabolic functions required for maintaining the structural and functional integrity of the cell. Taking the maintenance of ATP, biosynthesis of ceramide, cardiolipin and further important phospholipids as examples, we analyse how a changed supply of glucose, lactate, fatty acids and ketone bodies may influence the efficiency of these essential processes. CONCLUSIONS: CardioNet is a functionally validated metabolic network of the human cardiomyocyte that enables theorectical studies of cellular metabolic processes crucial for the accomplishment of an adequate cardiac output. This model is hosted on BioModels Database and identified by: MODEL1212040000 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. PMID: 20587024 . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
DG225_226 + CDP_ethanolamine __> PE225_226 + CMP
Linoleate + O2 + 2 Ferrocytochrome b5 __> gamma_Linolenate + 2 Ferricytochrome b5
_2E__Hexadecenoyl_ACP + NADPH __> Hexadecanoyl_ACP + NADP+
N_Acetylspermine + O2 __> H2O2 + N_Acetylspermidine + Aminopropionaldehyde
UDP_N_acetyl_D_galactosamine@cyto + UMP@golgi __> UDP_N_acetyl_D_galactosamine@golgi + UMP@cyto
NAD+ + _S__3_Hydroxy_2_methylbutyryl_CoA <=> 2_Methylacetoacetyl_CoA + NADH
GalCerd181_160 __> Galactose + Cerd181_160
gamma_Linolenoyl_CoA@cyto __> gamma_Linolenoyl_CoA@mito
Docosahexaenoic_acid@ext + atp@cyto __> Docosahexaenoic_acid@cyto + adp@cyto
N6,N6,N6_Trimethyl_L_lysine@cyto __> N6,N6,N6_Trimethyl_L_lysine@mito
Docosatetraenoyl_CoA + DG160_161 __> TAG160_161_224 + CoA
1MG225_3P + Docosahexaenoyl_CoA __> DG225_226_P + CoA
4_Maleylacetoacetate <=> Fumarylacetoacetate
Dihomo_gamma_linolenoyl_CoA + DG180_181 __> TAG180_181_203 + CoA
SAM + Tryptamine <=> SAH + N_Methyltryptamine
2_Amino_3_carboxymuconate semialdehyde __> Quinolinate
Docosapentaenoic_acid@cyto <=> Docosapentaenoic_acid@micro
Docosapentaenoyl_CoA + sn_Glycerol_3P __> CoA + 1MG225_3P
Methylmalonyl_CoA __> _R__Methylmalonyl_CoA
L_Formylkynurenine <=> Formate + Kynurenine
Cholesterol_ester_arach __> Cholesterol_ester_pool
Linoleoyl_CoA + 1MG182_3P __> DG182_182_P + CoA
Nicotinamide D_ribonucleotide __> Nicotinate ribonucleotide + NH3
4alpha_Methylzymosterol_4_carboxylate + NADP+ <=> 3_Keto_4_methylzymosterol + NADPH
Deoxyadenosine@ext __> Deoxyadenosine@cyto
3_Oxododecanoyl_ACP + NADPH __> D_3_Hydroxydodecanoyl_ACP + NADP+
_2E__Dodecenoyl_ACP + NADPH __> Dodecanoyl_ACP + NADP+
4 CoA + 4 FAD + 4 NAD+ + Palmitoyl_CoA __> 4 Acetyl_CoA + 4 FADH2 + 4 NADH + Octanoyl_CoA
Linoleate + ATP + CoA __> AMP + Linoleoyl_CoA
_4,7,10,13,16__docosapentaenoic_acid@ext + atp@cyto __> _4,7,10,13,16__docosapentaenoic_acid@cyto + adp@cyto
Folate + NADPH __> Dihydrofolate + NADP+
ATP + CoA + Butyrate __> AMP + Butyryl_CoA
3 O2 + 3 NADPH + Lanosterol __> 4,4_Dimethyl_5alpha_cholesta_8,14,24_trien_3beta_ol + Formate + 3 NADP+
Eicosadienoic_acid@ext + atp@cyto __> Eicosadienoic_acid@cyto + adp@cyto
TAG180_181_203 __> Dihomo_gamma_linolenate + DG180_181
5,10_Methylene_THF + Glycine <=> THF + Serine
Eicosapentaenoyl_CoA + DG182_203 __> TAG182_203_205 + CoA
NADPH + 6_Lactoyl_5,6,7,8_tetrahydropterin __> Tetrahydrobiopterin + NADP+
Cholesterol_ester_acetate __> Cholesterol_ester_pool
Acetaldehyde + NADP+ __> Acetate + NADPH
Docosahexaenoyl_CoA + DG160_161 __> TAG160_161_226 + CoA
Oleoyl_CoA + sn_Glycerol_3P __> CoA + 1MG181_3P
UDP_glucose + 2 NAD+ __> 2 NADH + UDP_glucuronate
Glycogenin_G7 __> Glycogenin + 7 Glucose_1P
Glyoxylate + Alanine <=> Glycine + Pyruvate
FAD@cyto + FADH2@endo <=> FAD@endo + FADH2@cyto
Zymosterol __> 5alpha_Cholesta_7,24_dien_3beta_ol
Docosapentaenoyl_CoA + DG182_203 __> TAG182_203_225 + CoA
Arachidonate@ext + atp@cyto __> Arachidonate@cyto + adp@cyto
Argininosuccinate <=> Fumarate + Arginine
myristic_acid + ATP + CoA __> Myristoyl_CoA + AMP
3_Methyl_2_oxobutyrate + CoA + NAD+ __> Isobutyryl_CoA + NADH
TAG160_161_224 __> Docosatetraenoic_acid + DG160_161
5 CoA + 4 FAD + 5 NAD+ + Oleoyl_CoA __> 5 Acetyl_CoA + 4 FADH2 + 5 NADH + Octanoyl_CoA
3 UDP_glucose + Glycogenin_G8 __> Glycogenin_G11 + 3 UDP
Sphinganine_1P <=> Ethanolamine_P + Hexadecanal
dCTP@cyto + ATP@mito __> dCTP@mito + ATP@cyto
Dihomo_gamma_linolenoyl_CoA + sn_Glycerol_3P __> CoA + 1MG203_3P
2_Aminoadipate 6_semialdehyde + NAD+ __> NADH + L_2_Aminoadipate
ATP + Succinate + CoA __> ADP + Succinyl_CoA
8Z_11Z_14Z_17Z_eicosatetraenoyl_CoA@cyto __> 8Z_11Z_14Z_17Z_eicosatetraenoyl_CoA@mito
_R__Mevalonate@cyto <=> _R__Mevalonate@peroxy
Sphinganine + Stearoyl_CoA __> Cerd180_180 + CoA
Docosapentaenoyl_CoA + DG160_161 __> TAG160_161_225 + CoA
Linoleoyl_CoA + 1MG203_3P __> DG203_182_P + CoA
Cholesterol_ester_lin __> Cholesterol_ester_pool
_R__3_Hydroxybutanoyl_ACP <=> But_2_enoyl_ACP
3 CoA + Lignoceroyl_CoA + 3 O2 + 3 NAD+ __> 3 Acetyl_CoA + 3 NADH + Stearoyl_CoA
Propanoyl_CoA + FAD __> FADH2 + Acrylyl_CoA
Docosahexaenoyl_CoA + CoA + NAD+ __> Acetyl_CoA + NADH + Eicosapentaenoyl_CoA
5 CoA + gamma_Linolenoyl_CoA + 5 NAD+ + 2 O2 __> 5 Acetyl_CoA + 2 H2O2 + 5 NADH + Octanoyl_CoA
myristic_acid@ext + atp@cyto __> myristic_acid@cyto + adp@cyto
Eicosapentaenoic_acid@lyso __> Eicosapentaenoic_acid@cyto
Fructose_6P + GAP <=> D_Xylulose_5P + Erythrose_4P
AKG + O2 + 4_Trimethylammoniobutanoate __> L_Carnitine + Succinate
5 CoA + 3 FAD + Linoleoyl_CoA + 5 NAD+ __> 5 Acetyl_CoA + 3 FADH2 + 5 NADH + Octanoyl_CoA
Nicotinate ribonucleotide __> Nicotinate D_ribonucleoside
CDP_diacylglycerol_pool __> CDP_DG160_161
TAG182_204_226 __> Docosahexaenoic_acid + DG182_204
NADPH + Acetoacetyl_ACP __> _R__3_Hydroxybutanoyl_ACP + NADP+
_2E__Decenoyl_ACP + NADPH __> Decanoyl_ACP + NADP+
UDP_glucose@cyto + UMP@micro <=> UDP_glucose@micro + UMP@cyto
Docosatetraenoyl_CoA@cyto __> Docosatetraenoyl_CoA@mito
ATP + Pyridoxamine __> ADP + Pyridoxamine_P
Glucono_1,5_lactone_6P@peroxy __> Glucono_1,5_lactone_6P@cyto
Docosapentaenoyl_CoA + DG180_181 __> TAG180_181_225 + CoA
2_Methylbutyryl_CoA + Dihydrolipoamide <=> S__2_Methylbutanoyl__dihydrolipoamide + CoA
ATP + Histidine + 4_Aminobutyrate __> AMP + Homocarnosine
gamma_Linolenoyl_CoA + Cholesterol __> CoA + Cholesterol_ester_gla
_S__3_Hydroxybutyryl_CoA <=> Crotonyl_CoA
_R__4_Phosphopantothenoyl_cysteine __> Phosphopantetheine
27 Alanine + 7 Cysteine + 22 Aspartate + 21 Glutamate + 14 Phenylalanine + 23 Glycine + 15 Histidine + 11 Isoleucine + 6 Lysine + 57 Leucine + 8 Methionine + 7 Asparagine + 38 Proline + 14 Glutamine + 29 Arginine + 17 Serine + 29 Threonine + 27 Valine + 4 Tryptophan + 11 Tyrosine __> alpha_Sarcoglycan
Dimethylglycine@cyto __> Dimethylglycine@mito
CDP_diacylglycerol_pool __> CDP_DG203_204
Homogentisate + O2 __> 4_Maleylacetoacetate
3_Hydroxy_N6,N6,N6_trimethyl_L_lysine __> 4_Trimethylammoniobutanal + Glycine
Myristoyl_CoA + NADP+ __> _2E__Tetradecenoyl_CoA + NADPH
UDP_glucose + Cerd181_180 __> UDP + GlcCerd181_180
4_Aminobutyrate@ext __> 4_Aminobutyrate@cyto
Sedoheptulose_7P + GAP <=> Ribose_5P + D_Xylulose_5P
Deoxyinosine __> Hypoxanthine + 2_Deoxy_D_ribose_1P
Cholesterol_ester_laur __> Cholesterol + lauric_acid
SAM + Ethanolamine_P <=> SAH + N_Methylethanolamine_P
Palmitolate + ATP + CoA __> _2E__Hexadecenoyl_CoA + AMP
PE182_204 + Serine __> PS182_204 + Ethanolamine
Docosapentaenoyl_CoA@cyto + ATP@cyto __> Docosapentaenoyl_CoA@peroxy + ADP@cyto
Glucono_1,5_lactone_6P <=> 6_Phospho_D_gluconate
D_3_Hydroxyhexanoyl_ACP <=> _2E__Hexenoyl_ACP
Acetyl_CoA + Glycine <=> CoA + 2_Amino_acetoacetate
NADPH + _2E__Tetradecenoyl_ACP __> Tetradecanoyl_ACP + NADP+
2_Deoxy_D_ribose_5P <=> GAP + Acetaldehyde
5,10_Methenyl_THF + NADPH __> 5,10_Methylene_THF + NADP+
CMP_N_acetylneuraminate + O2 + NADPH __> CMP_NeuNGc + NADP+
Eicosatetraenoic_acid + ATP + CoA __> 8Z_11Z_14Z_17Z_eicosatetraenoyl_CoA + AMP
Eicosapentaenoyl_CoA + DG160_161 __> TAG160_161_205 + CoA
NADPH + 3_Oxohexanoyl_ACP __> D_3_Hydroxyhexanoyl_ACP + NADP+
CoA + NAD+ + O2 + Tetracosatetraenoyl_CoA __> Acetyl_CoA + Docosatetraenoyl_CoA + NADH
Arginine + O2 + NADPH __> N__omega__Hydroxyarginine + NADP+
Eicosapentaenoyl_CoA + DG182_202 __> TAG182_202_205 + CoA
Arachidonyl_CoA + 9 CoA + 5 FAD + 9 NAD+ __> 10 Acetyl_CoA + 5 FADH2 + 9 NADH
3_Oxohexadecanoyl_ACP + NADPH __> _R__3_Hydroxypalmitoyl_ACP + NADP+
myristic_acid@lyso __> myristic_acid@cyto
2_Oxo_3_methylvalerate + CoA + NAD+ __> 2_Methylbutyryl_CoA + NADH
S_Adenosylmethioninamine + Putrescine __> 5_Methylthioadenosine + Spermidine
Stearoyl_CoA + O2 + 2 Ferrocytochrome b5 __> Oleoyl_CoA + 2 Ferricytochrome b5
TAG182_202_205 __> Eicosapentaenoic_acid + DG182_202
Eicosapentaenoic_acid + 2 NADPH + Malonyl_CoA __> Docosapentaenoic_acid + CoA + 2 NADP+
ATP + Citrate + CoA __> ADP + Acetyl_CoA + OAA
4_Hydroxyphenylpyruvate + O2 __> Homogentisate
Lignocerate + ATP + CoA __> Lignoceroyl_CoA + AMP
NAD+ + O2 + N_Acetylneuraminate __> NeuNGc + NADH
FAD@cyto + FADH2@peroxy <=> FAD@peroxy + FADH2@cyto
GSH + Formaldehyde __> Hydroxymethylglutathione
GlcCerd181_160@cyto <=> GlcCerd181_160@micro
ATP + _R__5_Phosphomevalonate __> ADP + _R__5_Diphosphomevalonate
CoA + NAD+ + 2_Oxobutyrate __> Propanoyl_CoA + NADH
ATP + CoA + Propanoate __> AMP + Propanoyl_CoA
ATP + Citrulline + Aspartate __> AMP + Argininosuccinate
ATP + N_Formyl_GAR + Glutamine __> ADP + Glutamate + 5_Phosphoribosylformylglycinamidine
Linolenoyl_CoA + Cholesterol __> CoA + Cholesterol_ester_ala
Palmitate@ext + atp@cyto __> Palmitate@cyto + adp@cyto
Proline@cyto + Glutamate@mito <=> Proline@mito + Glutamate@cyto
Tetradecanoyl_ACP + Malonyl_ACP __> 3_Oxohexadecanoyl_ACP + ACP
ATP + Creatine <=> ADP + Phosphocreatine
Nicotinamide + PRPP __> Nicotinamide D_ribonucleotide
NAD+ + 4_Aminobutanal __> 4_Aminobutyrate + NADH
Deoxyadenosine <=> 2_Deoxy_D_ribose_1P + Adenine
Phosphocholine@cyto <=> Phosphocholine@lyso
NAD+ __> AMP + Nicotinamide D_ribonucleotide
Cholesterol_ester_ala __> Cholesterol_ester_pool
TAG182_204_204 __> Eicosatetraenoic_acid + DG182_204
Palmitolate@ext + atp@cyto __> Palmitolate@cyto + adp@cyto
22 Alanine + 6 Cysteine + 15 Glutamate + 20 Phenylalanine + 18 Glycine + 9 Histidine + 12 Isoleucine + 39 Leucine + 8 Methionine + 15 Proline + 14 Glutamine + 12 Arginine + 31 Serine + 25 Threonine + 28 Valine + 7 Tryptophan + 13 Tyrosine + 1400 ATP + 26 Aspartate + 18 Lysine + 12 Asparagine __> Glycogenin + 1050 ADP + 350 AMP
dTDP@cyto + adp@mito <=> dTDP@mito + adp@cyto
Hexanoate@ext + atp@cyto __> Hexanoate@cyto + adp@cyto
GalCerd181_160@cyto <=> GalCerd181_160@lyso
2oxoadp@cyto + 2_og@mito <=> 2oxoadp@mito + 2_og@cyto
Squalene + NADPH + O2 __> Squalene 2,3_oxide + NADP+
Valine + AKG <=> Glutamate + 3_Methyl_2_oxobutyrate
Thioredoxin + CDP __> dCDP + Oxidized thioredoxin
Leucine + AKG <=> Glutamate + 4_Methyl_2_oxopentanoate
5,6_Dihydrouracil __> 3_Ureidopropionate
UDP_N_acetylglucosamine <=> UDP_N_acetyl_D_galactosamine
PE180_181 + Serine __> PS180_181 + Ethanolamine
Nicotinate ribonucleotide <=> Nicotinate + PRPP
stearidonic acid + ATP + CoA __> Stearidonoyl_CoA + AMP
Cholesterol_ester_ol __> Cholesterol_ester_pool
Histamine + O2 __> Imidazole_4_acetaldehyde + H2O2 + NH3
GlcCerd181_160@cyto <=> GlcCerd181_160@lyso
Isocitrate + NAD+ __> Oxalosuccinate + NADH
ATP + 5_Phosphoribosylamine + Glycine __> ADP + GAR
CTP + N_Acetylneuraminate <=> CMP_N_acetylneuraminate
Glycogenin_G4G7 __> 3 Glucose_1P + Glycogenin_G4G4
NAD+ + Saccharopine __> Glutamate + 2_Aminoadipate 6_semialdehyde + NADH
_S__3_Hydroxybutyryl_CoA + NAD+ __> NADH + Acetoacetyl_CoA
Eicosatetraenoic_acid@ext + atp@cyto __> Eicosatetraenoic_acid@cyto + adp@cyto
Tetrahydrobiopterin + Tryptophan + O2 __> 5_Hydroxy_L_tryptophan + Dihydrobiopterin
3_Methyl_2_oxobutyrate + Lipoamide __> S__2_Methylpropanoyl__dihydrolipoamide
UDP_glucuronate@cyto + UMP@micro <=> UDP_glucuronate@micro + UMP@cyto
dIDP@cyto + adp@mito <=> dIDP@mito + adp@cyto
170 Alanine + 14 Cysteine + 106 Aspartate + 253 Glutamate + 58 Phenylalanine + 72 Glycine + 34 Histidine + 87 Isoleucine + 202 Lysine + 214 Leucine + 52 Methionine + 92 Asparagine + 32 Proline + 124 Glutamine + 113 Arginine + 96 Serine + 85 Threonine + 83 Valine + 10 Tryptophan + 38 Tyrosine __> Myosin7
5 CoA + 5 FAD + 5 NAD+ + Lauroyl_CoA __> 6 Acetyl_CoA + 5 FADH2 + 5 NADH
_4,7,10,13,16__docosapentaenoic_acid + ATP + CoA __> Docosapentaenoyl_CoA + AMP
Elaidate@ext + atp@cyto __> Elaidate@cyto + adp@cyto
Docosatetraenoic_acid@cyto <=> Docosatetraenoic_acid@micro
Serine + Homocysteine __> L_Cystathionine
Cystine __> Pyruvate + Thiocysteine + NH3
Dihomo_gamma_linolenate + ATP + CoA __> Dihomo_gamma_linolenoyl_CoA + AMP
Docosahexaenoyl_CoA + DG182_203 __> TAG182_203_226 + CoA
2_Methyl_3_oxopropanoate + CoA + NAD+ __> _R__Methylmalonyl_CoA + NADH
dGTP@cyto + ATP@mito __> dGTP@mito + ATP@cyto
TAG182_204_224 __> Docosatetraenoic_acid + DG182_204
TAG180_181_224 __> Docosatetraenoic_acid + DG180_181
CDP_diacylglycerol_pool __> CDP_DG182_202
GDP_4_dehydro_6_deoxy_D_mannose + NADH __> GDP_L_fucose + NAD+
Farnesyl_PP + Isopentenyl_PP <=> Geranylgeranyl_PP
2_Oxoadipate + CoA + NAD+ __> Glutaryl_CoA + NADH
Dihomo_gamma_linolenate@ext + atp@cyto __> Dihomo_gamma_linolenate@cyto + adp@cyto
THF + Formate + ATP __> ADP + 10_Formyl_THF
Glutamine + PRPP __> 5_Phosphoribosylamine + Glutamate
5 CoA + FAD + 5 NAD+ + Stearidonoyl_CoA __> 5 Acetyl_CoA + FADH2 + 5 NADH + Octanoyl_CoA
ATP + Xanthosine_5P + Glutamine __> AMP + GMP + Glutamate
Carbamoyl_P + Aspartate __> N_Carbamoyl_L_aspartate
Eicosatetraenoic_acid + O2 + 2 Ferrocytochrome b5 __> Eicosapentaenoic_acid + 2 Ferricytochrome b5
Betaine aldehyde@mito __> Betaine aldehyde@cyto
Docosatetraenoyl_CoA@cyto + ATP@cyto __> Docosatetraenoyl_CoA@peroxy + ADP@cyto
3_Hydroxyisobutyrate + NAD+ __> 2_Methyl_3_oxopropanoate + NADH
NAD+ + Betaine aldehyde __> Betaine + NADH
29 Alanine + 2 Cysteine + 16 Aspartate + 51 Glutamate + Phenylalanine + 8 Glycine + 2 Histidine + 9 Isoleucine + 25 Lysine + 32 Leucine + 5 Methionine + 10 Asparagine + Proline + 14 Glutamine + 17 Arginine + 8 Serine + 8 Threonine + 8 Valine + Tryptophan + 3 Tyrosine __> Tropomyosin_alpha4_chain
_R__3_Hydroxybutanoate@cyto __> _R__3_Hydroxybutanoate@mito
Docosahexaenoyl_CoA@cyto __> Docosahexaenoyl_CoA@mito
3_Oxooctanoyl_ACP + NADPH __> _R__3_Hydroxyoctanoyl_ACP + NADP+
36 Alanine + Cysteine + 20 Aspartate + 60 Glutamate + Phenylalanine + 3 Glycine + 2 Histidine + 12 Isoleucine + 38 Lysine + 34 Leucine + 7 Methionine + 7 Asparagine + Proline + 15 Glutamine + 14 Arginine + 11 Serine + 9 Threonine + 8 Valine + 6 Tyrosine __> Tropomyosin_alpha3_chain
212 Alanine + 20 Cysteine + 94 Aspartate + 257 Glutamate + 47 Phenylalanine + 89 Glycine + 36 Histidine + 50 Isoleucine + 160 Lysine + 243 Leucine + 40 Methionine + 60 Asparagine + 36 Proline + 133 Glutamine + 151 Arginine + 87 Serine + 83 Threonine + 94 Valine + 11 Tryptophan + 38 Tyrosine __> Myosin7B
Pyridoxamine_P + O2 __> H2O2 + Pyridoxal_P + NH3
TAG160_161_203 __> Dihomo_gamma_linolenate + DG160_161
Stearate + ATP + CoA __> Stearoyl_CoA + AMP
ATP + 5_Formyl_THF __> ADP + 5,10_Methenyl_THF
ATP + CoA + Linolenate __> Linolenoyl_CoA + AMP
UDP_xylose@cyto + UMP@endo <=> UDP_xylose@endo + UMP@cyto
Stearoyl_CoA + Cholesterol __> CoA + Cholesterol_ester_stea
N_Methylhistamine + O2 __> Methylimidazole acetaldehyde + H2O2 + NH3
Succinate semialdehyde + NAD+ __> Succinate + NADH
Dihomo_gamma_linolenoyl_CoA + Cholesterol __> Cholesterol_ester_dihomogla + CoA
N_Ribosylnicotinamide <=> Nicotinamide + Ribose_1P
10_Formyl_THF + GAR __> THF + N_Formyl_GAR
AKG + 3_Hydroxy_L_kynurenine <=> 4__2_Amino_3_hydroxyphenyl__2,4_dioxobutanoate + Glutamate
2,5_Diaminopyrimidine nucleoside triphosphate __> 2,5_Diamino_6__5_triphosphoryl_3,4_trihydroxy_2_oxopentyl__ amino_4_oxopyrimidine
Lysine + SAM __> Protein N6_methyl_L_lysine + SAH
Deoxythymidine@cyto <=> Deoxythymidine@mito
Docosatetraenoyl_CoA + DG182_204 __> TAG182_204_224 + CoA
Myristoyl_CoA@cyto __> Myristoyl_CoA@mito
ATP + 5_Phosphoribosylformylglycinamidine __> ADP + AIR
3_Oxotetradecanoyl_ACP + NADPH __> HMA + NADP+
Kynurenine + O2 + NADPH __> 3_Hydroxy_L_kynurenine + NADP+
GalCerd181_180 __> Galactose + Cerd181_180
S_Adenosylmethioninamine + Spermidine __> 5_Methylthioadenosine + Spermine
Deoxythymidine@ext __> Deoxythymidine@cyto
2_Hydroxybutyrate@ext <=> 2_Hydroxybutyrate@cyto
Dihomo_gamma_linolenoyl_CoA + DG182_202 __> TAG182_202_203 + CoA
Decanoyl_ACP + Malonyl_ACP __> 3_Oxododecanoyl_ACP + ACP
Docosatetraenoyl_CoA + sn_Glycerol_3P __> CoA + 1MG224_3P
Oleate@ext + atp@cyto __> Oleate@cyto + adp@cyto
ATP + Histidine + beta_Alanine __> AMP + Carnosine
ATP + 3_Methylcrotonyl_CoA <=> ADP + 3_Methylglutaconyl_CoA
Docosatetraenoyl_CoA + DG182_203 __> TAG182_203_224 + CoA
PE160_161 + Serine __> PS160_161 + Ethanolamine
Docosapentaenoic_acid@ext + atp@cyto __> Docosapentaenoic_acid@cyto + adp@cyto
sn_Glycerol_3P@cyto <=> sn_Glycerol_3P@mito
_2E__Octenoyl_ACP + NADPH __> Octanoyl_ACP + NADP+
SAM + Nicotinamide __> SAH + 1_Methylnicotinamide
ADP@peroxy + ATP@cyto __> ADP@cyto + ATP@peroxy
_2E__Octadecenoyl_ACP + NADPH __> Stearoyl_ACP + NADP+
Putrescine + O2 __> H2O2 + 4_Aminobutanal + NH3
TAG182_203_226 __> Docosahexaenoic_acid + DG182_203
Cholesterol_ester_myr __> Cholesterol + myristic_acid
5_Formiminotetrahydrofolate __> 5,10_Methenyl_THF + NH3
3_Hydroxypropionyl_CoA __> Hydracrylate + CoA
Cholesterol_ester_acetate __> Cholesterol + Propanoate
CDP_diacylglycerol_pool __> CDP_DG182_204
UTP + N_Acetylglucosamine_1P __> UDP_N_acetylglucosamine
4_Aminobutyrate + AKG <=> Succinate semialdehyde + Glutamate
Acetyl_CoA + Spermidine __> CoA + N_Acetylspermidine
Propanoyl_CoA + Acetyl_CoA <=> CoA + 2_Methylacetoacetyl_CoA
gamma_Linolenoyl_CoA + DG160_161 __> TAG160_161_183 + CoA
gamma_Linolenate + O2 + 2 Ferrocytochrome b5 __> stearidonic acid + 2 Ferricytochrome b5
Acetyl_ACP + Malonyl_ACP __> ACP + Acetoacetyl_ACP
N_Acetylneuraminate_9P <=> N_Acetylneuraminate
Eicosapentaenoic_acid@cyto <=> Eicosapentaenoic_acid@micro
Glycine + Succinyl_CoA <=> CoA + 2_Amino_3_oxoadipate
TAG180_181_226 __> Docosahexaenoic_acid + DG180_181
Hypoxanthine@cyto <=> Hypoxanthine@peroxy
2_Aminomuconate + NADPH __> 2_Oxoadipate + NH3 + NADP+
3_Oxostearoyl_ACP + NADPH __> 3_Hydroxystearoyl_ACP + NADP+
CDP_diacylglycerol_pool __> CDP_DG225_226