MODEL1208280000
type: SBMLModel
parameter: k15
species: TGFb TGFbR P
parameter: k12
reaction: r22
species: s2
compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
volume units: volume
reaction: r10
units def: length
parameter: k10
species: s3
reaction: r17
is described by: http://identifiers.org/pubmed/22051045
parameter: TGFb
reaction: r16
reaction: r27
reaction: r13
parameter: Vn
parameter: Vc
reaction: r28
parameter: k7
species: Smad P N
compartment: default
name: Cellière2011 - Plasticity of TGF-β Signalling
parameter: k3
units def: area
reaction: r5
parameter: k14
reaction: r21
species: Smad P Smad P N
reaction: r12
reaction: r1
reaction: r19
curated: false
reaction: r15
species: I Smad TGFb TGFbR P
species: TGFb TGFbR
species: CoSmad N
species: I Smad mRNA2
reaction: r9
species: Smad P Smad P
parameter: k9
reaction: r26
species: I Smad
species: s4
compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
parameter: http://identifiers.org/biomodels.db/MODEL1208280000#h
species: Smad
parameter: k19
units def: volume
length unit: length
reaction: r7
units def: substance
species: Smad P
reaction: r23
parameter: k6
species: Smad P CoSmad
parameter: k2
reaction: r11
species: TGFbR
reaction: r3
area units: area
parameter: k17
reaction: r4
parameter: k13
reaction: r20
parameter: k11
species: s1
reaction: r18
reaction: r29
species: I Smad mRNA1
units def: time
reaction: r14
reaction: r25
parameter: k18
species: Smad N
reaction: r8
species: Smad P CoSmad N
parameter: k8

k15
type: Parameter
constant: true
value: 1.0
name: k15

TGFb TGFbR P
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: TGFb_TGFbR_P

http://identifiers.org/biomodels.db/MODEL1208280000#c
type: Compartment
constant: true
units: volume
size: 2.3
spatial dimensions: 3.0
name: cytoplasm

volume
type: SBMLUnitsDef
unit: CDMT00100
name: volume

CDMT00100
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

k12
type: Parameter
constant: true
value: 5.7
name: k12

r22
type: Reaction
kinetic law: CDMT00073
modifier: 082158
product: CDMT00072
reactant: CDMT00071
fast: false
reversible: false
name: r22

Smad P Smad P N
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
name: Smad_P_Smad_P_N

http://identifiers.org/biomodels.db/MODEL1208280000#n
type: Compartment
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0
name: nucleus

CDMT00072
type: SpeciesReference
stoichiometry: 1.0
species: Smad P N

Smad P N
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
name: Smad_P_N

CDMT00071
type: SpeciesReference
stoichiometry: 1.0
species: Smad P Smad P N

s2
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: s2

r10
type: Reaction
kinetic law: CDMT00035
modifier: 082002
product: CDMT00034
reactant: CDMT00033
fast: false
reversible: false
name: r10

Smad P
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: Smad_P

CDMT00034
type: SpeciesReference
stoichiometry: 1.0
species: Smad P Smad P

Smad P Smad P
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: Smad_P_Smad_P

CDMT00033
type: SpeciesReference
stoichiometry: 1.0
species: Smad P

length
type: SBMLUnitsDef
unit: CDMT00102
name: length

CDMT00102
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: METRE

k10
type: Parameter
constant: true
value: 0.002
name: k10

s3
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: s3

r17
type: Reaction
kinetic law: CDMT00058
modifier: 082098
product: CDMT00057
reactant: CDMT00056
fast: false
reversible: false
name: r17

CDMT00057
type: SpeciesReference
stoichiometry: 1.0
species: Smad P N

CDMT00056
type: SpeciesReference
stoichiometry: 1.0
species: Smad P

TGFb
type: Parameter
constant: true
value: 0.2
name: TGFb

r16
type: Reaction
kinetic law: CDMT00055
modifier: 082086
product: CDMT00054
reactant: CDMT00053
fast: false
reversible: false
name: r16

CDMT00054
type: SpeciesReference
stoichiometry: 1.0
species: Smad P Smad P N

CDMT00053
type: SpeciesReference
stoichiometry: 1.0
species: Smad P Smad P

r27
type: Reaction
kinetic law: CDMT00091
modifier: 082230
product: CDMT00090
reactant: CDMT00089
fast: false
reversible: false
name: r27

I Smad mRNA2
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: I_Smad_mRNA2

CDMT00090
type: SpeciesReference
stoichiometry: 1.0
species: s2

CDMT00089
type: SpeciesReference
stoichiometry: 1.0
species: I Smad mRNA2

r13
type: Reaction
kinetic law: CDMT00046
modifier: 082050
product: CDMT00045
product: CDMT00044
reactant: CDMT00043
fast: false
reversible: false
name: r13

Smad P CoSmad
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: Smad_P_CoSmad

CDMT00045
type: SpeciesReference
stoichiometry: 1.0
species: CoSmad

CoSmad
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 50.8
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: CoSmad

CDMT00044
type: SpeciesReference
stoichiometry: 1.0
species: Smad P

CDMT00043
type: SpeciesReference
stoichiometry: 1.0
species: Smad P CoSmad

Vn
type: Parameter
constant: true
value: 1.0
name: Vn

Vc
type: Parameter
constant: true
value: 2.3
name: Vc

r28
type: Reaction
kinetic law: CDMT00095
modifier: 082242
modifier: CDMT00094
product: CDMT00093
reactant: CDMT00092
fast: false
reversible: false
name: r28

CDMT00093
type: SpeciesReference
stoichiometry: 1.0
species: I Smad

I Smad
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: I_Smad

CDMT00092
type: SpeciesReference
stoichiometry: 1.0
species: s3

k7
type: Parameter
constant: true
value: 4.04E-4
name: k7

default
type: Compartment
constant: true
units: volume
size: 1.0
spatial dimensions: 3.0

k3
type: Parameter
constant: true
value: 0.01
name: k3

area
type: SBMLUnitsDef
unit: CDMT00101
name: area

CDMT00101
type: SBMLUnit
exponent: 2.0
scale: 0
multipler: 1.0
kind: METRE

r5
type: Reaction
name: r5
fast: false
reversible: false
modifier: 081918
modifier: 081930
reactant: CDMT00015
product: CDMT00017
reactant: CDMT00016
kinetic law: CDMT00018

CDMT00015
type: SpeciesReference
stoichiometry: 1.0
species: TGFb TGFbR P

CDMT00017
type: SpeciesReference
stoichiometry: 1.0
species: I Smad TGFb TGFbR P

I Smad TGFb TGFbR P
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: I_Smad_TGFb_TGFbR_P

CDMT00016
type: SpeciesReference
stoichiometry: 1.0
species: I Smad

k14
type: Parameter
constant: true
value: 0.0017
name: k14

r21
type: Reaction
kinetic law: CDMT00070
modifier: 082146
product: CDMT00069
reactant: CDMT00068
fast: false
reversible: false
name: r21

CDMT00069
type: SpeciesReference
stoichiometry: 1.0
species: Smad P Smad P N

CDMT00068
type: SpeciesReference
stoichiometry: 1.0
species: Smad P N

r12
type: Reaction
reactant: CDMT00040
name: r12
kinetic law: CDMT00042
fast: false
product: CDMT00041
modifier: 082026
reactant: CDMT00039
reversible: false
modifier: 082038

CDMT00040
type: SpeciesReference
stoichiometry: 1.0
species: CoSmad

CDMT00041
type: SpeciesReference
stoichiometry: 1.0
species: Smad P CoSmad

CDMT00039
type: SpeciesReference
stoichiometry: 1.0
species: Smad P

r1
type: Reaction
kinetic law: CDMT00005
modifier: 081870
product: CDMT00004
reactant: CDMT00003
fast: false
reversible: false
name: r1

TGFb TGFbR
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: TGFb_TGFbR

CDMT00004
type: SpeciesReference
stoichiometry: 1.0
species: TGFbR

TGFbR
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.01
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: TGFbR

CDMT00003
type: SpeciesReference
stoichiometry: 1.0
species: TGFb TGFbR

r19
type: Reaction
kinetic law: CDMT00064
modifier: 082122
product: CDMT00063
reactant: CDMT00062
fast: false
reversible: false
name: r19

CDMT00063
type: SpeciesReference
stoichiometry: 1.0
species: Smad P CoSmad N

Smad P CoSmad N
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
name: Smad_P_CoSmad_N

CDMT00062
type: SpeciesReference
stoichiometry: 1.0
species: Smad P CoSmad

r15
type: Reaction
kinetic law: CDMT00052
modifier: 082074
product: CDMT00051
reactant: CDMT00050
fast: false
reversible: false
name: r15

CoSmad N
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 50.8
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
name: CoSmad_N

CDMT00051
type: SpeciesReference
stoichiometry: 1.0
species: CoSmad

CDMT00050
type: SpeciesReference
stoichiometry: 1.0
species: CoSmad N

r9
type: Reaction
kinetic law: CDMT00032
modifier: 081990
product: CDMT00031
reactant: CDMT00030
fast: false
reversible: false
name: r9

Smad N
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 30.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
name: Smad_N

CDMT00031
type: SpeciesReference
stoichiometry: 1.0
species: Smad

Smad
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 30.6
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: Smad

CDMT00030
type: SpeciesReference
stoichiometry: 1.0
species: Smad N

k9
type: Parameter
constant: true
value: 0.0056
name: k9

r26
type: Reaction
kinetic law: CDMT00088
modifier: 082218
product: CDMT00087
reactant: CDMT00086
fast: false
reversible: false
name: r26

I Smad mRNA1
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
name: I_Smad_mRNA1

CDMT00087
type: SpeciesReference
stoichiometry: 1.0
species: I Smad mRNA2

CDMT00086
type: SpeciesReference
stoichiometry: 1.0
species: I Smad mRNA1

s4
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#c
name: s4

http://identifiers.org/biomodels.db/MODEL1208280000#h
type: Parameter
constant: true
value: 2.0
name: h

k19
type: Parameter
constant: true
value: 0.001
name: k19

r7
type: Reaction
name: r7
fast: false
kinetic law: CDMT00026
modifier: 081966
modifier: 081954
reversible: false
modifier: CDMT00025
reactant: CDMT00023
product: CDMT00024

CDMT00023
type: SpeciesReference
stoichiometry: 1.0
species: Smad

CDMT00024
type: SpeciesReference
stoichiometry: 1.0
species: Smad P

substance
type: SBMLUnitsDef
unit: CDMT00099
name: substance

CDMT00099
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: MOLE

r23
type: Reaction
reactant: CDMT00075
name: r23
modifier: 082170
product: CDMT00076
fast: false
reversible: false
reactant: CDMT00074
kinetic law: CDMT00077
modifier: 082182

CDMT00075
type: SpeciesReference
stoichiometry: 1.0
species: CoSmad N

CDMT00076
type: SpeciesReference
stoichiometry: 1.0
species: Smad P CoSmad N

CDMT00074
type: SpeciesReference
stoichiometry: 1.0
species: Smad P N

k6
type: Parameter
constant: true
value: 0.1
name: k6

k2
type: Parameter
constant: true
value: 0.023
name: k2

r11
type: Reaction
kinetic law: CDMT00038
modifier: 082014
product: CDMT00037
reactant: CDMT00036
fast: false
reversible: false
name: r11

CDMT00037
type: SpeciesReference
stoichiometry: 1.0
species: Smad P

CDMT00036
type: SpeciesReference
stoichiometry: 1.0
species: Smad P Smad P

r3
type: Reaction
kinetic law: CDMT00011
modifier: 081894
product: CDMT00010
reactant: CDMT00009
fast: false
reversible: false
name: r3

CDMT00010
type: SpeciesReference
stoichiometry: 1.0
species: TGFb TGFbR P

CDMT00009
type: SpeciesReference
stoichiometry: 1.0
species: TGFb TGFbR

k17
type: Parameter
constant: true
value: 0.001
name: k17

r4
type: Reaction
kinetic law: CDMT00014
modifier: 081906
product: CDMT00013
reactant: CDMT00012
fast: false
reversible: false
name: r4

CDMT00013
type: SpeciesReference
stoichiometry: 1.0
species: TGFb TGFbR

CDMT00012
type: SpeciesReference
stoichiometry: 1.0
species: TGFb TGFbR P

k13
type: Parameter
constant: true
value: 0.00657
name: k13

r20
type: Reaction
kinetic law: CDMT00067
modifier: 082134
product: CDMT00066
reactant: CDMT00065
fast: false
reversible: false
name: r20

CDMT00066
type: SpeciesReference
stoichiometry: 1.0
species: Smad N

CDMT00065
type: SpeciesReference
stoichiometry: 1.0
species: Smad P N

k11
type: Parameter
constant: true
value: 0.016
name: k11

s1
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: http://identifiers.org/biomodels.db/MODEL1208280000#n
name: s1

r18
type: Reaction
kinetic law: CDMT00061
modifier: 082110
product: CDMT00060
reactant: CDMT00059
fast: false
reversible: false
name: r18

CDMT00060
type: SpeciesReference
stoichiometry: 1.0
species: Smad P

CDMT00059
type: SpeciesReference
stoichiometry: 1.0
species: Smad P N

r29
type: Reaction
kinetic law: CDMT00098
modifier: 082254
product: CDMT00097
reactant: CDMT00096
fast: false
reversible: false
name: r29

CDMT00097
type: SpeciesReference
stoichiometry: 1.0
species: s4

CDMT00096
type: SpeciesReference
stoichiometry: 1.0
species: I Smad

time
type: SBMLUnitsDef
unit: CDMT00103
name: time

CDMT00103
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: SECOND

r14
type: Reaction
kinetic law: CDMT00049
modifier: 082062
product: CDMT00048
reactant: CDMT00047
fast: false
reversible: false
name: r14

CDMT00048
type: SpeciesReference
stoichiometry: 1.0
species: CoSmad N

CDMT00047
type: SpeciesReference
stoichiometry: 1.0
species: CoSmad

r25
type: Reaction
kinetic law: CDMT00085
modifier: 082206
modifier: CDMT00084
product: CDMT00083
reactant: CDMT00082
fast: false
reversible: false
name: r25

CDMT00083
type: SpeciesReference
stoichiometry: 1.0
species: I Smad mRNA1

CDMT00082
type: SpeciesReference
stoichiometry: 1.0
species: s1

k18
type: Parameter
constant: true
value: 0.002
name: k18

r8
type: Reaction
kinetic law: CDMT00029
modifier: 081978
product: CDMT00028
reactant: CDMT00027
fast: false
reversible: false
name: r8

CDMT00028
type: SpeciesReference
stoichiometry: 1.0
species: Smad N

CDMT00027
type: SpeciesReference
stoichiometry: 1.0
species: Smad

k8
type: Parameter
constant: true
value: 0.0026
name: k8

k5
type: Parameter
constant: true
value: 0.01
name: k5

r24
type: Reaction
kinetic law: CDMT00081
modifier: 082194
product: CDMT00080
product: CDMT00079
reactant: CDMT00078
fast: false
reversible: false
name: r24

CDMT00080
type: SpeciesReference
stoichiometry: 1.0
species: CoSmad N

CDMT00079
type: SpeciesReference
stoichiometry: 1.0
species: Smad P N

CDMT00078
type: SpeciesReference
stoichiometry: 1.0
species: Smad P CoSmad N

k4
type: Parameter
constant: true
value: 0.01
name: k4

k1
type: Parameter
constant: true
value: 1.5E-4
name: k1

r2
type: Reaction
kinetic law: CDMT00008
modifier: 081882
product: CDMT00007
reactant: CDMT00006
fast: false
reversible: false
name: r2

CDMT00007
type: SpeciesReference
stoichiometry: 1.0
species: TGFb TGFbR

CDMT00006
type: SpeciesReference
stoichiometry: 1.0
species: TGFbR

k16
type: Parameter
constant: true
value: 8.0E-4
name: k16

r6
type: Reaction
kinetic law: CDMT00022
modifier: 081942
product: CDMT00021
product: CDMT00020
reactant: CDMT00019
fast: false
reversible: false
name: r6

CDMT00021
type: SpeciesReference
stoichiometry: 1.0
species: I Smad

CDMT00020
type: SpeciesReference
stoichiometry: 1.0
species: TGFb TGFbR

CDMT00019
type: SpeciesReference
stoichiometry: 1.0
species: I Smad TGFb TGFbR P