MODEL1208060000
type: SBMLModel
constraint: 643854
reaction: 722084
reaction: 735942
reaction: 759298
constraint: 671748
species: 624535
constraint: 662965
constraint: 661105
constraint: 662917
constraint: 654218
reaction: 789017
species: 640062
reaction: 706314
constraint: 673200
constraint: 677483
species: 640170
constraint: 642390
reaction: 687966
constraint: 673860
reaction: 835009
constraint: 644381
species: 629995
species: 626599
reaction: 728731
constraint: 677231
reaction: 709697
constraint: 668424
constraint: 644945
species: 632575
species: 628651
constraint: 663133
species: 625255
constraint: 666217
reaction: 815581
species: 637962
reaction: 746471
species: 626491
reaction: 796408
reaction: 812425
constraint: 676175
reaction: 798424
reaction: 821580
constraint: 648410
species: 640566
reaction: 830999
constraint: 654338
species: 637027
reaction: 711293
constraint: 645713
constraint: 660793
constraint: 652082
species: 636379
species: 624403
species: 638682
species: 625531
reaction: 780642
reaction: 852211
constraint: 658070
reaction: 707190
species: 641418
reaction: 697336
constraint: 677351
reaction: 727484
reaction: 722516
species: 633787
constraint: 665377
constraint: 657326
species: 629863
constraint: 650390
reaction: 700240
species: 626467
constraint: 662305
reaction: 822720
constraint: 651974
reaction: 737730
reaction: 721240
constraint: 666396
reaction: 733819
reaction: 807890

643854
type: Constraint
message: Warning: Species concentration PPi_r is out of the soft bounds.

722084
type: Reaction
reactant: 722108
is: K07515
fast: false
name: r0715
is: K00022
reversible: false
is: K01782
is: K07516
is: K07514
notes: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: K01825
is: ENSMUSG00000022853
is: ENSMUSG00000027984
product: 722132
is: R04737
is: ENSMUSG00000025745
reactant: 722096
product: 722120

722108
type: SpeciesReference
stoichiometry: 1.0
species: 635155

635155
type: Species
initial amount: NaN
name: (S)-3-Hydroxyhexadecanoyl-CoA_p
is: C05258
in compartment: 623899
has only substance units: false
is: http://identifiers.org/pubchem.compound/7645
initial concentration: 1.0E-5
is: CHEBI:27402
constant: false
boundary condition: false

623899
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: p

722132
type: SpeciesReference
stoichiometry: 1.0
species: 624475

624475
type: Species
initial amount: NaN
name: NADH_p
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
in compartment: 623899
initial concentration: 2.0E-5
is: C00004
has only substance units: false
is: CHEBI:16908
constant: false

722096
type: SpeciesReference
stoichiometry: 1.0
species: 624427

624427
type: Species
is: http://identifiers.org/cas/53-84-9
boundary condition: false
is: CHEBI:15846
initial concentration: 8.87E-5
in compartment: 623899
is: http://identifiers.org/pubchem.compound/3305
is: C00003
name: NAD+_p
initial amount: NaN
has only substance units: false
constant: false

722120
type: SpeciesReference
stoichiometry: 1.0
species: 635179

635179
type: Species
name: 3-Oxopalmitoyl-CoA_p
initial concentration: 1.0E-5
boundary condition: false
in compartment: 623899
has only substance units: false
is: CHEBI:15491
is: C05259
constant: false
is: http://identifiers.org/pubchem.compound/7646
initial amount: NaN

735942
type: Reaction
reactant: 735966
product: 736002
name: r0991
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.201.2
reactant: 735978
is: ENSMUSG00000027048
reversible: false
product: 735990
fast: false
product: 736014
reactant: 735954

735966
type: SpeciesReference
stoichiometry: 2.0
species: 624259

624259
type: Species
in compartment: 623911
name: H2O_c
initial amount: NaN
is: CHEBI:15377
is: http://identifiers.org/cas/7732-18-5
boundary condition: false
is: C00001
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3303
has only substance units: false

623911
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: c

736002
type: SpeciesReference
stoichiometry: 2.0
species: 624727

624727
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: C00009
initial concentration: 0.0105
is: http://identifiers.org/cas/7664-38-2
in compartment: 623911
is: CHEBI:18367
name: Pi_c
is: http://identifiers.org/pubchem.compound/3311
has only substance units: false

735978
type: SpeciesReference
stoichiometry: 1.0
species: 633523

633523
type: Species
initial concentration: 2.6E-4
is: CHEBI:17687
is: http://identifiers.org/pubchem.compound/5027
constant: false
name: Glycocholate_c
is: C01921
in compartment: 623911
initial amount: NaN
has only substance units: false
boundary condition: false
is: http://identifiers.org/cas/475-31-0

735990
type: SpeciesReference
stoichiometry: 2.0
species: 624655

624655
type: Species
name: ADP_c
has only substance units: false
constant: false
is: C00008
is: CHEBI:16761
initial amount: NaN
in compartment: 623911
boundary condition: false
initial concentration: 1.32E-4
is: http://identifiers.org/pubchem.compound/3310
is: http://identifiers.org/cas/20398-34-9

736014
type: SpeciesReference
stoichiometry: 1.0
species: 633511

633511
type: Species
is: http://identifiers.org/pubchem.compound/5027
is: http://identifiers.org/cas/475-31-0
boundary condition: true
is: CHEBI:17687
constant: false
is: C01921
in compartment: 623887
name: Glycocholate_b
initial concentration: 2.6E-4
initial amount: NaN
has only substance units: false

623887
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: b

735954
type: SpeciesReference
stoichiometry: 2.0
species: 624331

624331
type: Species
is: CHEBI:15422
boundary condition: true
is: http://identifiers.org/cas/56-65-5
is: C00002
constant: false
initial concentration: 3.38E-4
has only substance units: false
initial amount: NaN
in compartment: 623911
name: ATP_c
is: http://identifiers.org/pubchem.compound/3304

759298
type: Reaction
is: ENSMUSG00000025153
product: 759334
is: R07764
reactant: 759310
notes: fatty acid synthase Polyunsaturated fatty acid biosynthesis EC:2.3.1.85
product: 759322
is: K02372
fast: false
name: r1315
reversible: true
is: K11533

759334
type: SpeciesReference
stoichiometry: 1.0
species: 624259

759310
type: SpeciesReference
stoichiometry: 1.0
species: 638766

638766
type: Species
has only substance units: false
name: 3-Hydroxystearoyl-ACP_c
boundary condition: false
constant: false
is: C16220
in compartment: 623911
is: http://identifiers.org/pubchem.compound/47205528
initial amount: NaN
initial concentration: 2.6E-4

759322
type: SpeciesReference
stoichiometry: 1.0
species: 638778

638778
type: Species
initial concentration: 2.6E-4
constant: false
name: (2E)-Octadecenoyl-ACP_c
is: C16221
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205529
in compartment: 623911
initial amount: NaN

671748
type: Constraint
message: Error: Species concentration Dihomo-gamma-linolenoyl-CoA_r is out of the hard bounds.

624535
type: Species
is: C00006
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-4
is: http://identifiers.org/pubchem.compound/3308
is: http://identifiers.org/cas/53-59-8
in compartment: 623923
name: NADP+_r
is: CHEBI:18009

623923
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: r

662965
type: Constraint
message: Error: Species concentration Adenylosuccinate_c is out of the hard bounds.

661105
type: Constraint
message: Warning: Species concentration Glycocholate_b is out of the soft bounds.

662917
type: Constraint
message: Error: Species concentration Dopamine_s is out of the hard bounds.

654218
type: Constraint
message: Warning: Species concentration Citrulline_c is out of the soft bounds.

789017
type: Reaction
product: 789077
notes: Y+LAT2 Utilized transport
name: r1685
reactant: 789041
product: 789065
fast: false
product: 789089
is: ENSMUSG00000031904
reactant: 789029
reactant: 789053
reversible: false

789077
type: SpeciesReference
stoichiometry: 1.0
species: 629563

629563
type: Species
initial amount: NaN
name: Homoserine_s
boundary condition: true
initial concentration: 2.6E-4
is: C00263
in compartment: 623935
constant: false
is: http://identifiers.org/cas/672-15-1
is: CHEBI:15699
is: http://identifiers.org/pubchem.compound/3561
has only substance units: false

623935
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: s

789041
type: SpeciesReference
stoichiometry: 1.0
species: 629551

629551
type: Species
in compartment: 623911
is: http://identifiers.org/cas/672-15-1
boundary condition: false
is: CHEBI:15699
is: http://identifiers.org/pubchem.compound/3561
initial amount: NaN
name: Homoserine_c
has only substance units: false
is: C00263
constant: false
initial concentration: 2.6E-4

789065
type: SpeciesReference
stoichiometry: 1.0
species: 625627

625627
type: Species
constant: false
initial amount: NaN
is: http://identifiers.org/cas/56-40-6
in compartment: 623911
has only substance units: false
is: C00037
name: Glycine_c
boundary condition: true
is: http://identifiers.org/pubchem.compound/3339
is: CHEBI:15428
initial concentration: 2.6E-4

789089
type: SpeciesReference
stoichiometry: 1.0
species: 633079

633079
type: Species
has only substance units: false
in compartment: 623911
is: http://identifiers.org/cas/7440-23-5
initial concentration: 0.01
initial amount: NaN
is: CHEBI:29101
constant: false
is: C01330
boundary condition: false
name: Na+_c
is: http://identifiers.org/pubchem.compound/4541

789029
type: SpeciesReference
stoichiometry: 1.0
species: 625639

625639
type: Species
is: http://identifiers.org/cas/56-40-6
initial concentration: 2.6E-4
in compartment: 623935
is: http://identifiers.org/pubchem.compound/3339
has only substance units: false
is: CHEBI:15428
is: C00037
initial amount: NaN
name: Glycine_s
constant: false
boundary condition: true

789053
type: SpeciesReference
stoichiometry: 1.0
species: 633091

633091
type: Species
constant: false
initial concentration: 0.16
initial amount: NaN
is: CHEBI:29101
is: C01330
boundary condition: true
is: http://identifiers.org/pubchem.compound/4541
name: Na+_s
has only substance units: false
in compartment: 623935
is: http://identifiers.org/cas/7440-23-5

640062
type: Species
name: prostaglandin-b1_c
is: CHEBI:27624
boundary condition: false
is: http://identifiers.org/cas/13345-51-2
constant: false
in compartment: 623911
is: C00959
initial concentration: 2.6E-4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4210
has only substance units: false

706314
type: Reaction
reactant: 706338
is: K01825
is: R01975
is: K07514
reactant: 706326
name: r0460
is: K07516
reversible: true
is: ENSMUSG00000022853
is: K01782
notes: (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase Fatty acid metabolism / Lysine degradation / Tryptophan metabolism / Butanoate metabolism EC:1.1.1.35
product: 706350
fast: false
is: ENSMUSG00000027984
is: K00022
product: 706362

706338
type: SpeciesReference
stoichiometry: 1.0
species: 624415

624415
type: Species
in compartment: 623863
is: C00003
boundary condition: false
initial amount: NaN
initial concentration: 8.87E-5
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3305
is: http://identifiers.org/cas/53-84-9
name: NAD+_m
is: CHEBI:15846

623863
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: m

706326
type: SpeciesReference
stoichiometry: 1.0
species: 632815

632815
type: Species
is: C01144
initial concentration: 1.0E-5
in compartment: 623863
is: CHEBI:15453
constant: false
is: http://identifiers.org/pubchem.compound/4375
boundary condition: false
initial amount: NaN
has only substance units: false
name: (S)-3-Hydroxybutyryl-CoA_m

706350
type: SpeciesReference
stoichiometry: 1.0
species: 624463

624463
type: Species
is: C00004
name: NADH_m
has only substance units: false
constant: false
in compartment: 623863
initial amount: NaN
initial concentration: 2.0E-5
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
is: CHEBI:16908

706362
type: SpeciesReference
stoichiometry: 1.0
species: 630187

630187
type: Species
has only substance units: false
initial concentration: 1.0E-5
is: C00332
boundary condition: false
is: http://identifiers.org/pubchem.compound/3626
initial amount: NaN
name: Acetoacetyl-CoA_m
is: CHEBI:15345
in compartment: 623863
is: http://identifiers.org/cas/1420-36-6
constant: false

673200
type: Constraint
message: Warning: Species concentration thromboxane-b2_s is out of the soft bounds.

677483
type: Constraint
message: Error: Species concentration GDP-activated-fucose_c is out of the hard bounds.

640170
type: Species
name: prostaglandin-d1_s
initial amount: NaN
is: http://identifiers.org/cas/17968-82-0
is: CHEBI:27696
is: C06438
has only substance units: false
constant: false
initial concentration: 2.6E-4
boundary condition: false
is: http://identifiers.org/pubchem.compound/8672
in compartment: 623935

642390
type: Constraint
message: Warning: Species concentration ApoC2_c is out of the soft bounds.

687966
type: Reaction
reactant: 687990
product: 688014
is: ENSMUSG00000027187
reactant: 687978
is: K03781
is: K00429
is: ENSMUSG00000026701
is: R00602
is: K03782
notes: Hydorogen-peroxide:hydrogen-peroxide oxidoreductase Methane metabolism EC:1.11.1.7
is: K00430
name: r0162
fast: false
is: K11188
product: 688002
reversible: true

687990
type: SpeciesReference
stoichiometry: 1.0
species: 625387

625387
type: Species
initial concentration: 2.6E-4
has only substance units: false
boundary condition: false
is: C00027
name: H2O2_c
is: http://identifiers.org/pubchem.compound/3329
initial amount: NaN
is: CHEBI:16240
constant: false
in compartment: 623911
is: http://identifiers.org/cas/7722-84-1

688014
type: SpeciesReference
stoichiometry: 1.0
species: 626347

626347
type: Species
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3367
boundary condition: false
name: Formaldehyde_c
initial concentration: 2.6E-4
is: C00067
initial amount: NaN
in compartment: 623911
is: http://identifiers.org/cas/50-00-0
is: CHEBI:16842

687978
type: SpeciesReference
stoichiometry: 1.0
species: 627775

627775
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:17790
initial amount: NaN
is: http://identifiers.org/cas/67-56-1
constant: false
is: http://identifiers.org/pubchem.compound/3432
name: Methanol_c
is: C00132
in compartment: 623911
initial concentration: 2.6E-4

688002
type: SpeciesReference
stoichiometry: 2.0
species: 624259

673860
type: Constraint
message: Error: Species concentration sulfotaurolithocholate_s is out of the hard bounds.

835009
type: Reaction
is: ENSMUSG00000030236
fast: false
name: r2274
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: 835045
product: 835081
reversible: true
reactant: 835033
product: 835057
product: 835069
reactant: 835021

835045
type: SpeciesReference
stoichiometry: 1.0
species: 639990

639990
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: S-glutathionyl-ethacrynic-acid_c

835081
type: SpeciesReference
stoichiometry: 1.0
species: 640002

640002
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623935
name: S-glutathionyl-ethacrynic-acid_s

835033
type: SpeciesReference
stoichiometry: 1.0
species: 629719

629719
type: Species
initial concentration: 0.0026
is: http://identifiers.org/pubchem.compound/3583
is: CHEBI:17544
initial amount: NaN
name: HCO3-_c
in compartment: 623911
boundary condition: false
constant: false
is: C00288
has only substance units: false

835057
type: SpeciesReference
stoichiometry: 1.0
species: 640134

640134
type: Species
is: CHEBI:27555
in compartment: 623911
is: http://identifiers.org/cas/49825-91-4
initial concentration: 2.6E-4
constant: false
is: http://identifiers.org/pubchem.compound/8239
has only substance units: false
is: C05955
initial amount: NaN
boundary condition: false
name: prostaglandin-c2_c

835069
type: SpeciesReference
stoichiometry: 1.0
species: 629731

629731
type: Species
in compartment: 623935
boundary condition: false
is: CHEBI:17544
constant: false
initial concentration: 0.0026
name: HCO3-_s
initial amount: NaN
has only substance units: false
is: C00288
is: http://identifiers.org/pubchem.compound/3583

835021
type: SpeciesReference
stoichiometry: 1.0
species: 640146

640146
type: Species
name: prostaglandin-c2_s
has only substance units: false
is: C05955
constant: false
initial amount: NaN
initial concentration: 2.6E-4
in compartment: 623935
boundary condition: false
is: CHEBI:27555
is: http://identifiers.org/cas/49825-91-4
is: http://identifiers.org/pubchem.compound/8239

644381
type: Constraint
message: Warning: Species concentration AMP_p is out of the soft bounds.

629995
type: Species
constant: false
is: http://identifiers.org/cas/541-15-1
is: CHEBI:16347
is: http://identifiers.org/pubchem.compound/3612
in compartment: 623863
initial concentration: 2.6E-4
name: L-Carnitine_m
has only substance units: false
initial amount: NaN
is: C00318
boundary condition: false

626599
type: Species
is: C00079
is: http://identifiers.org/pubchem.compound/3379
is: CHEBI:17295
boundary condition: false
is: http://identifiers.org/cas/63-91-2
initial amount: NaN
in compartment: 623851
initial concentration: 2.6E-4
name: Phenylalanine_l
has only substance units: false
constant: false

623851
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: l

728731
type: Reaction
is: ENSMUSG00000025792
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: 728779
fast: false
name: r0832
reactant: 728743
product: 728767
reversible: true
reactant: 728755

728779
type: SpeciesReference
stoichiometry: 1.0
species: 626107

626107
type: Species
is: http://identifiers.org/pubchem.compound/3359
constant: false
is: C00059
name: Sulfate_c
initial concentration: 0.0026
is: http://identifiers.org/cas/7664-93-9
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:16189
in compartment: 623911

728743
type: SpeciesReference
stoichiometry: 1.0
species: 628123

628123
type: Species
constant: false
is: C00149
is: CHEBI:30797
is: http://identifiers.org/pubchem.compound/3449
is: http://identifiers.org/cas/97-67-6
name: Malate_c
has only substance units: false
in compartment: 623911
initial concentration: 0.00505
initial amount: NaN
boundary condition: false

728767
type: SpeciesReference
stoichiometry: 1.0
species: 628135

628135
type: Species
name: Malate_m
in compartment: 623863
initial concentration: 0.00505
is: C00149
boundary condition: false
initial amount: NaN
is: http://identifiers.org/cas/97-67-6
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3449
is: CHEBI:30797

728755
type: SpeciesReference
stoichiometry: 1.0
species: 626131

626131
type: Species
is: http://identifiers.org/pubchem.compound/3359
is: http://identifiers.org/cas/7664-93-9
is: C00059
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 0.0026
name: Sulfate_m
is: CHEBI:16189
in compartment: 623863

677231
type: Constraint
message: Warning: Species concentration Collagen_ITA2_c is out of the soft bounds.

709697
type: Reaction
reversible: true
is: K00287
notes: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
fast: false
product: 709733
is: ENSMUSG00000021707
name: r0512
reactant: 709721
reactant: 709709
product: 709745
is: R02235
is: K13998

709733
type: SpeciesReference
stoichiometry: 1.0
species: 631290

631290
type: Species
in compartment: 623911
boundary condition: false
constant: false
name: Folate_c
is: http://identifiers.org/pubchem.compound/3787
is: http://identifiers.org/cas/59-30-3
has only substance units: false
is: CHEBI:27470
initial amount: NaN
is: C00504
initial concentration: 2.6E-4

709721
type: SpeciesReference
stoichiometry: 1.0
species: 624403

624403
type: Species
initial amount: NaN
has only substance units: false
is: C00003
is: http://identifiers.org/pubchem.compound/3305
boundary condition: false
initial concentration: 8.87E-5
name: NAD+_c
is: http://identifiers.org/cas/53-84-9
is: CHEBI:15846
in compartment: 623911
constant: false

709709
type: SpeciesReference
stoichiometry: 1.0
species: 630870

630870
type: Species
initial concentration: 2.6E-4
constant: false
has only substance units: false
name: Dihydrofolate_c
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3705
is: C00415
is: CHEBI:15633
in compartment: 623911
is: http://identifiers.org/cas/4033-27-6

709745
type: SpeciesReference
stoichiometry: 1.0
species: 624451

624451
type: Species
boundary condition: true
has only substance units: false
in compartment: 623911
constant: false
is: CHEBI:16908
is: http://identifiers.org/pubchem.compound/3306
is: C00004
name: NADH_c
initial concentration: 2.0E-5
initial amount: NaN

668424
type: Constraint
message: Warning: Species concentration ApoTransferin_c is out of the soft bounds.

644945
type: Constraint
message: Error: Species concentration UDP-glucose_s is out of the hard bounds.

632575
type: Species
initial concentration: 2.6E-4
name: 4-Maleylacetoacetate_c
boundary condition: false
is: C01036
in compartment: 623911
is: http://identifiers.org/pubchem.compound/4279
has only substance units: false
initial amount: NaN
constant: false
is: http://identifiers.org/cas/5698-52-2
is: CHEBI:47904

628651
type: Species
boundary condition: true
is: http://identifiers.org/cas/57-88-5
is: C00187
has only substance units: false
initial amount: NaN
initial concentration: 1.0E-8
name: Cholesterol_b
in compartment: 623887
constant: false
is: CHEBI:16113
is: http://identifiers.org/pubchem.compound/3487

663133
type: Constraint
message: Error: Species concentration 2-Aminoadipate_6-semialdehyde_c is out of the hard bounds.

625255
type: Species
constant: false
boundary condition: false
name: Acetyl-CoA_c
initial concentration: 5.05E-4
is: http://identifiers.org/cas/72-89-9
is: CHEBI:15351
is: http://identifiers.org/pubchem.compound/3326
has only substance units: false
is: C00024
in compartment: 623911
initial amount: NaN

666217
type: Constraint
message: Warning: Species concentration 3,4-Dihydroxymandelate_m is out of the soft bounds.

815581
type: Reaction
product: 815617
is: ENSMUSG00000030492
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
reactant: 815605
name: r2004
reversible: false
reactant: 815593
product: 815629

815617
type: SpeciesReference
stoichiometry: 1.0
species: 625819

625819
type: Species
name: Lysine_c
is: CHEBI:18019
is: http://identifiers.org/cas/56-87-1
boundary condition: true
is: C00047
has only substance units: false
constant: false
in compartment: 623911
is: http://identifiers.org/pubchem.compound/3349
initial amount: NaN
initial concentration: 2.6E-4

815605
type: SpeciesReference
stoichiometry: 1.0
species: 628531

628531
type: Species
boundary condition: true
is: CHEBI:16414
constant: false
is: http://identifiers.org/pubchem.compound/3483
initial amount: NaN
name: Valine_c
is: C00183
is: http://identifiers.org/cas/72-18-4
initial concentration: 2.6E-4
in compartment: 623911
has only substance units: false

815593
type: SpeciesReference
stoichiometry: 1.0
species: 625831

625831
type: Species
is: C00047
initial amount: NaN
name: Lysine_s
initial concentration: 2.6E-4
boundary condition: true
constant: false
in compartment: 623935
is: http://identifiers.org/cas/56-87-1
has only substance units: false
is: http://identifiers.org/pubchem.compound/3349
is: CHEBI:18019

815629
type: SpeciesReference
stoichiometry: 1.0
species: 628543

628543
type: Species
boundary condition: true
is: CHEBI:16414
is: http://identifiers.org/pubchem.compound/3483
constant: false
is: C00183
in compartment: 623935
is: http://identifiers.org/cas/72-18-4
initial amount: NaN
name: Valine_s
initial concentration: 2.6E-4
has only substance units: false

637962
type: Species
is: http://identifiers.org/pubchem.compound/4266224
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1-Acylglycerol-3P-stea_c

746471
type: Reaction
reversible: true
is: ENSMUSG00000020456
product: 746519
name: r1114
notes: EC:1.2.4.2
reactant: 746483
product: 746543
product: 746531
reactant: 746495
fast: false
is: R08549
reactant: 746507

746519
type: SpeciesReference
stoichiometry: 1.0
species: 624463

746483
type: SpeciesReference
stoichiometry: 1.0
species: 625363

625363
type: Species
is: CHEBI:30915
constant: false
boundary condition: false
initial concentration: 5.5E-4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3328
name: AKG_m
is: C00026
has only substance units: false
is: http://identifiers.org/cas/328-50-7
in compartment: 623863

746543
type: SpeciesReference
stoichiometry: 1.0
species: 626875

626875
type: Species
is: CHEBI:15380
initial amount: NaN
is: C00091
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3391
initial concentration: 2.6E-4
name: Succinyl-CoA_m
is: http://identifiers.org/cas/604-98-8
has only substance units: false
in compartment: 623863

746531
type: SpeciesReference
stoichiometry: 1.0
species: 624883

624883
type: Species
name: CO2_m
is: CHEBI:16526
has only substance units: false
initial concentration: 0.025
is: http://identifiers.org/cas/124-38-9
is: C00011
boundary condition: false
constant: false
in compartment: 623863
is: http://identifiers.org/pubchem.compound/3313
initial amount: NaN

746495
type: SpeciesReference
stoichiometry: 1.0
species: 624811

624811
type: Species
is: CHEBI:15346
constant: false
is: C00010
is: http://identifiers.org/cas/85-61-0
has only substance units: false
is: http://identifiers.org/pubchem.compound/3312
name: CoA_m
initial amount: NaN
boundary condition: false
in compartment: 623863
initial concentration: 2.6E-4

746507
type: SpeciesReference
stoichiometry: 1.0
species: 624415

626491
type: Species
constant: false
initial amount: NaN
is: http://identifiers.org/cas/63-39-8
is: http://identifiers.org/pubchem.compound/3375
is: CHEBI:15713
is: C00075
boundary condition: true
in compartment: 623935
name: UTP_s
has only substance units: false
initial concentration: 2.6E-4

796408
type: Reaction
reactant: 796432
reversible: false
product: 796456
name: r1773
product: 796468
reactant: 796420
notes: Y+LAT2 Utilized transport
fast: false
is: ENSMUSG00000031904
reactant: 796444
product: 796480

796432
type: SpeciesReference
stoichiometry: 1.0
species: 628531

796456
type: SpeciesReference
stoichiometry: 1.0
species: 626575

626575
type: Species
has only substance units: false
initial concentration: 2.6E-4
name: Phenylalanine_c
in compartment: 623911
is: CHEBI:17295
constant: false
is: C00079
is: http://identifiers.org/pubchem.compound/3379
is: http://identifiers.org/cas/63-91-2
initial amount: NaN
boundary condition: true

796468
type: SpeciesReference
stoichiometry: 1.0
species: 628543

796420
type: SpeciesReference
stoichiometry: 1.0
species: 626587

626587
type: Species
name: Phenylalanine_s
is: http://identifiers.org/cas/63-91-2
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
is: CHEBI:17295
in compartment: 623935
is: C00079
constant: false
is: http://identifiers.org/pubchem.compound/3379

796444
type: SpeciesReference
stoichiometry: 1.0
species: 633091

796480
type: SpeciesReference
stoichiometry: 1.0
species: 633079

812425
type: Reaction
reactant: 812437
is: ENSMUSG00000031904
name: r1963
reactant: 812449
reactant: 812461
product: 812485
reversible: false
product: 812497
product: 812473
notes: Y+LAT2 Utilized transport
fast: false

812437
type: SpeciesReference
stoichiometry: 1.0
species: 628087

628087
type: Species
boundary condition: true
is: CHEBI:17203
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3448
initial amount: NaN
name: Proline_s
initial concentration: 2.6E-4
in compartment: 623935
is: http://identifiers.org/cas/147-85-3
is: C00148

812449
type: SpeciesReference
stoichiometry: 1.0
species: 633091

812461
type: SpeciesReference
stoichiometry: 1.0
species: 626155

626155
type: Species
in compartment: 623911
has only substance units: false
is: http://identifiers.org/pubchem.compound/3362
is: CHEBI:16467
is: http://identifiers.org/cas/74-79-3
is: C00062
constant: false
name: Arginine_c
boundary condition: true
initial concentration: 2.6E-4
initial amount: NaN

812485
type: SpeciesReference
stoichiometry: 1.0
species: 633079

812497
type: SpeciesReference
stoichiometry: 1.0
species: 626167

626167
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3362
has only substance units: false
is: CHEBI:16467
is: C00062
name: Arginine_s
is: http://identifiers.org/cas/74-79-3
in compartment: 623935
constant: false
initial concentration: 2.6E-4
boundary condition: true

812473
type: SpeciesReference
stoichiometry: 1.0
species: 628075

628075
type: Species
in compartment: 623911
name: Proline_c
initial concentration: 2.6E-4
has only substance units: false
constant: false
is: C00148
boundary condition: true
is: http://identifiers.org/pubchem.compound/3448
is: http://identifiers.org/cas/147-85-3
is: CHEBI:17203
initial amount: NaN

676175
type: Constraint
message: Warning: Species concentration Collagen_CO4A4_c is out of the soft bounds.

798424
type: Reaction
notes: Y+LAT2 Utilized transport
reactant: 798448
product: 798472
reactant: 798436
fast: false
product: 798484
product: 798496
reversible: false
is: ENSMUSG00000031904
reactant: 798460
name: r1797

798448
type: SpeciesReference
stoichiometry: 1.0
species: 626539

626539
type: Species
is: http://identifiers.org/pubchem.compound/3378
is: http://identifiers.org/cas/73-22-3
in compartment: 623911
constant: false
initial concentration: 2.6E-4
has only substance units: false
boundary condition: true
is: C00078
initial amount: NaN
name: Tryptophan_c
is: CHEBI:16828

798472
type: SpeciesReference
stoichiometry: 1.0
species: 627007

627007
type: Species
is: CHEBI:17561
is: C00097
name: Cysteine_c
has only substance units: false
initial amount: NaN
boundary condition: true
in compartment: 623911
initial concentration: 2.6E-4
is: http://identifiers.org/cas/52-90-4
constant: false
is: http://identifiers.org/pubchem.compound/3397

798436
type: SpeciesReference
stoichiometry: 1.0
species: 627019

627019
type: Species
in compartment: 623935
initial concentration: 2.6E-4
is: http://identifiers.org/cas/52-90-4
is: C00097
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3397
is: CHEBI:17561
boundary condition: true
name: Cysteine_s
initial amount: NaN

798484
type: SpeciesReference
stoichiometry: 1.0
species: 626551

626551
type: Species
is: http://identifiers.org/cas/73-22-3
is: http://identifiers.org/pubchem.compound/3378
is: C00078
initial concentration: 2.6E-4
has only substance units: false
initial amount: NaN
in compartment: 623935
name: Tryptophan_s
constant: false
is: CHEBI:16828
boundary condition: true

798496
type: SpeciesReference
stoichiometry: 1.0
species: 633079

798460
type: SpeciesReference
stoichiometry: 1.0
species: 633091

821580
type: Reaction
product: 821628
name: r2104
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: 821592
reversible: true
product: 821616
is: ENSMUSG00000032902
reactant: 821604
fast: false

821628
type: SpeciesReference
stoichiometry: 1.0
species: 628387

628387
type: Species
is: C00164
name: Acetoacetate_s
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
in compartment: 623935
is: http://identifiers.org/pubchem.compound/3464
is: http://identifiers.org/cas/541-50-4
is: CHEBI:13705
initial amount: NaN
constant: false

821592
type: SpeciesReference
stoichiometry: 1.0
species: 625351

625351
type: Species
in compartment: 623935
is: http://identifiers.org/cas/328-50-7
name: AKG_s
is: CHEBI:30915
initial concentration: 5.5E-4
constant: false
initial amount: NaN
has only substance units: false
is: C00026
boundary condition: true
is: http://identifiers.org/pubchem.compound/3328

821616
type: SpeciesReference
stoichiometry: 1.0
species: 625339

625339
type: Species
in compartment: 623911
has only substance units: false
is: http://identifiers.org/cas/328-50-7
name: AKG_c
initial concentration: 5.5E-4
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3328
constant: false
is: CHEBI:30915
is: C00026

821604
type: SpeciesReference
stoichiometry: 1.0
species: 628375

628375
type: Species
is: C00164
has only substance units: false
is: http://identifiers.org/pubchem.compound/3464
in compartment: 623911
initial concentration: 2.6E-4
name: Acetoacetate_c
is: http://identifiers.org/cas/541-50-4
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:13705

648410
type: Constraint
message: Warning: Species concentration Glucose-1P_s is out of the soft bounds.

640566
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: 3-oxomyrist-7-enoyl-CoA_m

830999
type: Reaction
name: r2227
reactant: 831035
reversible: true
fast: false
product: 831071
is: ENSMUSG00000030236
product: 831059
product: 831047
reactant: 831023
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: 831011

831035
type: SpeciesReference
stoichiometry: 1.0
species: 639918

639918
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: glutathionyl-leuc4_c

831071
type: SpeciesReference
stoichiometry: 1.0
species: 639930

639930
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623935
name: glutathionyl-leuc4_s

831059
type: SpeciesReference
stoichiometry: 1.0
species: 629731

831047
type: SpeciesReference
stoichiometry: 1.0
species: 634759

634759
type: Species
initial amount: NaN
name: Dehydroepiandrosterone_sulfate_c
is: C04555
initial concentration: 2.6E-4
boundary condition: false
constant: false
in compartment: 623911
is: http://identifiers.org/pubchem.compound/7160
has only substance units: false
is: CHEBI:16814

831023
type: SpeciesReference
stoichiometry: 1.0
species: 629719

831011
type: SpeciesReference
stoichiometry: 1.0
species: 634771

634771
type: Species
has only substance units: false
is: CHEBI:16814
boundary condition: true
initial concentration: 2.6E-4
constant: false
is: http://identifiers.org/pubchem.compound/7160
is: C04555
name: Dehydroepiandrosterone_sulfate_s
initial amount: NaN
in compartment: 623935

654338
type: Constraint
message: Warning: Species concentration Glucosamine_s is out of the soft bounds.

637027
type: Species
is: P00738
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Haptoglobin_c

711293
type: Reaction
notes: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
is: R02467
reactant: 711305
reactant: 711317
reversible: true
product: 711329
fast: false
is: K10712
name: r0539
is: ENSMUSG00000057134

711305
type: SpeciesReference
stoichiometry: 1.0
species: 633319

633319
type: Species
name: Cysteamine_c
is: C01678
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:17141
is: http://identifiers.org/pubchem.compound/4821
in compartment: 623911
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/60-23-1

711317
type: SpeciesReference
stoichiometry: 1.0
species: 624595

624595
type: Species
name: O2_c
in compartment: 623911
is: http://identifiers.org/cas/7782-44-7
is: C00007
initial concentration: 5.05E-5
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3309
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:15379

711329
type: SpeciesReference
stoichiometry: 1.0
species: 631374

631374
type: Species
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3802
initial concentration: 2.6E-4
constant: false
has only substance units: false
boundary condition: false
name: Hypotaurine_c
is: C00519
is: http://identifiers.org/cas/300-84-5
is: CHEBI:16668

645713
type: Constraint
message: Error: Species concentration Lysine_l is out of the hard bounds.

660793
type: Constraint
message: Warning: Species concentration L-Fuculose_c is out of the soft bounds.

652082
type: Constraint
message: Warning: Species concentration Thymidine_c is out of the soft bounds.

636379
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/8053
has only substance units: false
in compartment: 623911
boundary condition: false
initial concentration: 2.6E-4
name: (2E)-Dodecenoyl-ACP_c
initial amount: NaN
is: C05758

638682
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: Acyl-CoA-CL-pool_m

625531
type: Species
constant: false
is: CHEBI:15366
name: Acetate_c
in compartment: 623911
is: C00033
has only substance units: false
initial concentration: 2.6E-4
boundary condition: false
is: http://identifiers.org/cas/64-19-7
is: http://identifiers.org/pubchem.compound/3335
initial amount: NaN

780642
type: Reaction
fast: false
is: ENSMUSG00000040010
name: r1551
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: 780690
product: 780678
reactant: 780654
reactant: 780666
reversible: true

780690
type: SpeciesReference
stoichiometry: 1.0
species: 627571

627571
type: Species
is: http://identifiers.org/pubchem.compound/3423
is: C00123
name: Leucine_s
in compartment: 623935
initial concentration: 2.6E-4
initial amount: NaN
is: http://identifiers.org/cas/61-90-5
has only substance units: false
is: CHEBI:15603
boundary condition: true
constant: false

780678
type: SpeciesReference
stoichiometry: 1.0
species: 625627

780654
type: SpeciesReference
stoichiometry: 1.0
species: 625639

780666
type: SpeciesReference
stoichiometry: 1.0
species: 627559

627559
type: Species
is: C00123
constant: false
initial concentration: 2.6E-4
is: CHEBI:15603
has only substance units: false
in compartment: 623911
name: Leucine_c
is: http://identifiers.org/pubchem.compound/3423
initial amount: NaN
boundary condition: true
is: http://identifiers.org/cas/61-90-5

852211
type: Reaction
product: 852237
reactant: 852224
notes: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: ENSMUSG00000027075
fast: false
reversible: true
name: r2535

852237
type: SpeciesReference
stoichiometry: 1.0
species: 629551

852224
type: SpeciesReference
stoichiometry: 1.0
species: 629563

658070
type: Constraint
message: Error: Species concentration Cholate_s is out of the hard bounds.

707190
type: Reaction
is: K00526
name: r0473
product: 707238
reversible: true
is: R02017
is: ENSMUSG00000022292
fast: false
is: K10807
reactant: 707202
is: K10808
is: ENSMUSG00000030978
product: 707250
reactant: 707226
notes: 2'-Deoxyadenosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase Purine metabolism EC:1.17.4.1
is: ENSMUSG00000020649
is: K00524
is: K00525
reactant: 707214

707238
type: SpeciesReference
stoichiometry: 1.0
species: 630259

630259
type: Species
initial concentration: 1.0E-10
has only substance units: false
boundary condition: true
is: P10599
initial amount: NaN
is: C00342
name: Thioredoxin_c
constant: false
in compartment: 623911

707202
type: SpeciesReference
stoichiometry: 1.0
species: 630427

630427
type: Species
is: CHEBI:28862
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3652
in compartment: 623911
name: dGDP_c
initial concentration: 2.6E-4
constant: false
has only substance units: false
is: C00361

707250
type: SpeciesReference
stoichiometry: 1.0
species: 625567

625567
type: Species
boundary condition: false
is: CHEBI:17552
is: http://identifiers.org/pubchem.compound/3337
constant: false
initial amount: NaN
initial concentration: 1.32E-4
has only substance units: false
name: GDP_c
is: C00035
is: http://identifiers.org/cas/146-91-8
in compartment: 623911

707226
type: SpeciesReference
stoichiometry: 1.0
species: 624259

707214
type: SpeciesReference
stoichiometry: 1.0
species: 630271

630271
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Oxidized_thioredoxin_c

641418
type: Species
is: Q8NFW1
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_COMA1_c

697336
type: Reaction
is: ENSMUSG00000021036
is: ENSMUSG00000021468
is: K00654
notes: Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) Sphingolipid metabolism EC:2.3.1.50
product: 697396
product: 697372
name: r0313
reactant: 697348
reactant: 697360
product: 697384
is: ENSMUSG00000039092
fast: false
reversible: true
is: R01281

697396
type: SpeciesReference
stoichiometry: 1.0
species: 624859

624859
type: Species
boundary condition: false
initial concentration: 0.025
constant: false
has only substance units: false
name: CO2_c
is: CHEBI:16526
is: http://identifiers.org/cas/124-38-9
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3313
is: C00011

697372
type: SpeciesReference
stoichiometry: 1.0
species: 633979

633979
type: Species
initial amount: NaN
boundary condition: false
constant: false
in compartment: 623911
has only substance units: false
name: 3-Dehydrosphinganine_c
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/5855
is: CHEBI:17862
is: C02934

697348
type: SpeciesReference
stoichiometry: 1.0
species: 626299

626299
type: Species
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3365
is: C00065
boundary condition: true
in compartment: 623911
initial concentration: 2.6E-4
has only substance units: false
name: Serine_c
is: http://identifiers.org/cas/56-45-1
is: CHEBI:17115

697360
type: SpeciesReference
stoichiometry: 1.0
species: 628231

628231
type: Species
name: Palmitoyl-CoA_c
is: http://identifiers.org/pubchem.compound/3454
is: http://identifiers.org/cas/1763-10-6
in compartment: 623911
initial amount: NaN
initial concentration: 2.6E-4
has only substance units: false
is: CHEBI:15525
boundary condition: false
constant: false
is: C00154

697384
type: SpeciesReference
stoichiometry: 1.0
species: 624799

624799
type: Species
initial amount: NaN
is: C00010
constant: false
has only substance units: false
in compartment: 623911
is: http://identifiers.org/pubchem.compound/3312
name: CoA_c
initial concentration: 2.6E-4
boundary condition: true
is: http://identifiers.org/cas/85-61-0
is: CHEBI:15346

677351
type: Constraint
message: Warning: Species concentration Collagen_VWA2_c is out of the soft bounds.

727484
type: Reaction
product: 727508
reactant: 727496
notes: Vesicular transport
fast: false
reversible: true
name: r0808

727508
type: SpeciesReference
stoichiometry: 1.0
species: 624079

624079
type: Species
is: P02647
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623935
name: ApoA1_s

727496
type: SpeciesReference
stoichiometry: 1.0
species: 624067

624067
type: Species
is: P02647
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: ApoA1_c

722516
type: Reaction
is: K07514
is: ENSMUSG00000027984
is: R04741
is: ENSMUSG00000022853
is: K01782
product: 722564
is: K01825
is: K07516
is: K07515
reversible: false
product: 722552
is: ENSMUSG00000025745
is: K00022
reactant: 722540
fast: false
notes: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reactant: 722528
name: r0723

722564
type: SpeciesReference
stoichiometry: 1.0
species: 624475

722552
type: SpeciesReference
stoichiometry: 1.0
species: 635275

635275
type: Species
is: CHEBI:27868
constant: false
initial concentration: 1.0E-5
initial amount: NaN
has only substance units: false
in compartment: 623899
is: C05263
boundary condition: false
name: 3-Oxododecanoyl-CoA_p
is: http://identifiers.org/pubchem.compound/7650

722540
type: SpeciesReference
stoichiometry: 1.0
species: 624427

722528
type: SpeciesReference
stoichiometry: 1.0
species: 635251

635251
type: Species
in compartment: 623899
name: (S)-3-Hydroxydodecanoyl-CoA_p
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/7649
is: CHEBI:27668
has only substance units: false
boundary condition: false
is: C05262
initial concentration: 2.6E-4

633787
type: Species
is: CHEBI:16755
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/5536
is: C02528
in compartment: 623887
boundary condition: true
has only substance units: false
is: http://identifiers.org/cas/474-25-9
constant: false
initial amount: NaN
name: Chenodiol_b

665377
type: Constraint
message: Warning: Species concentration Lactose-6P_s is out of the soft bounds.

657326
type: Constraint
message: Error: Species concentration Betaine_aldehyde_c is out of the hard bounds.

629863
type: Species
has only substance units: false
initial concentration: 2.6E-4
constant: false
is: CHEBI:16436
is: http://identifiers.org/cas/987-78-0
in compartment: 623911
name: CDP-choline_c
is: http://identifiers.org/pubchem.compound/3601
initial amount: NaN
is: C00307
boundary condition: false

650390
type: Constraint
message: Error: Species concentration Asparagine_s is out of the hard bounds.

700240
type: Reaction
product: 700288
product: 700276
is: ENSMUSG00000025877
name: r0362
reactant: 700264
reactant: 700252
is: ENSMUSG00000037012
reversible: false
notes: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: ENSMUSG00000000628
fast: false

700288
type: SpeciesReference
stoichiometry: 1.0
species: 624655

700276
type: SpeciesReference
stoichiometry: 1.0
species: 630343

630343
type: Species
is: http://identifiers.org/cas/3616-42-0
in compartment: 623911
initial concentration: 2.6E-4
name: Glucosamine-6P_c
is: CHEBI:15873
is: C00352
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3645
initial amount: NaN
constant: false

700264
type: SpeciesReference
stoichiometry: 1.0
species: 624331

700252
type: SpeciesReference
stoichiometry: 1.0
species: 630115

630115
type: Species
is: CHEBI:47977
initial amount: NaN
is: http://identifiers.org/cas/3416-24-8
initial concentration: 2.6E-4
has only substance units: false
constant: false
is: C00329
in compartment: 623911
name: Glucosamine_c
boundary condition: true
is: http://identifiers.org/pubchem.compound/3623

626467
type: Species
initial concentration: 1.7E-5
boundary condition: false
is: http://identifiers.org/pubchem.compound/3374
name: PEP_m
is: C00074
constant: false
is: http://identifiers.org/cas/138-08-9
has only substance units: false
is: CHEBI:18021
initial amount: NaN
in compartment: 623863

662305
type: Constraint
message: Warning: Species concentration (2E)-Dodecenoyl-CoA_p is out of the soft bounds.

822720
type: Reaction
fast: false
product: 822756
product: 822768
reactant: 822744
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: ENSMUSG00000032902
reversible: true
reactant: 822732
name: r2123

822756
type: SpeciesReference
stoichiometry: 1.0
species: 628339

628339
type: Species
initial amount: NaN
is: http://identifiers.org/cas/79-09-4
boundary condition: false
is: CHEBI:30768
is: http://identifiers.org/pubchem.compound/3463
initial concentration: 2.6E-4
has only substance units: false
constant: false
name: Propanoate_c
in compartment: 623911
is: C00163

822768
type: SpeciesReference
stoichiometry: 1.0
species: 632155

632155
type: Species
is: http://identifiers.org/pubchem.compound/4038
initial concentration: 2.6E-4
boundary condition: false
is: C00777
is: http://identifiers.org/cas/302-79-4
is: CHEBI:15367
initial amount: NaN
name: Retinoate_s
constant: false
in compartment: 623935
has only substance units: false

822744
type: SpeciesReference
stoichiometry: 1.0
species: 632143

632143
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/4038
initial concentration: 2.6E-4
in compartment: 623911
is: C00777
name: Retinoate_c
is: http://identifiers.org/cas/302-79-4
initial amount: NaN
is: CHEBI:15367
constant: false
has only substance units: false

822732
type: SpeciesReference
stoichiometry: 1.0
species: 628351

628351
type: Species
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3463
initial amount: NaN
constant: false
is: C00163
boundary condition: true
is: CHEBI:30768
is: http://identifiers.org/cas/79-09-4
in compartment: 623935
name: Propanoate_s
has only substance units: false

651974
type: Constraint
message: Error: Species concentration Adenosine_s is out of the hard bounds.

737730
type: Reaction
product: 737754
reactant: 737742
notes: Postulated transport reaction
fast: false
reversible: true
name: r1022

737754
type: SpeciesReference
stoichiometry: 1.0
species: 635803

635803
type: Species
is: C05452
is: http://identifiers.org/pubchem.compound/7814
is: CHEBI:28047
initial concentration: 2.6E-4
has only substance units: false
constant: false
name: 5beta-Cholestane-3alpha,7alpha-diol_m
initial amount: NaN
in compartment: 623863
boundary condition: false

737742
type: SpeciesReference
stoichiometry: 1.0
species: 635791

635791
type: Species
name: 5beta-Cholestane-3alpha,7alpha-diol_c
constant: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/7814
has only substance units: false
in compartment: 623911
initial amount: NaN
is: C05452
is: CHEBI:28047
boundary condition: false

721240
type: Reaction
product: 721264
product: 721276
fast: false
is: R04568
is: ENSMUSG00000025153
is: K00668
notes: (3R)-3-Hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase Fatty acid biosynthesis EC:2.3.1.85
is: K00665
is: K11533
name: r0702
reactant: 721252
is: K02372
reversible: true

721264
type: SpeciesReference
stoichiometry: 1.0
species: 624259

721276
type: SpeciesReference
stoichiometry: 1.0
species: 636403

636403
type: Species
boundary condition: false
constant: false
is: C05760
has only substance units: false
initial amount: NaN
name: (2E)-Tetradecenoyl-ACP_c
in compartment: 623911
is: http://identifiers.org/pubchem.compound/8055
initial concentration: 2.6E-4

721252
type: SpeciesReference
stoichiometry: 1.0
species: 634879

634879
type: Species
has only substance units: false
boundary condition: false
in compartment: 623911
initial amount: NaN
initial concentration: 2.6E-4
is: C04688
constant: false
is: http://identifiers.org/pubchem.compound/7269
name: HMA_c

666396
type: Constraint
message: Error: Species concentration 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate_c is out of the hard bounds.

733819
type: Reaction
product: 733843
reactant: 733831
notes: Free diffusion
fast: false
reversible: true
name: r0940

733843
type: SpeciesReference
stoichiometry: 1.0
species: 629659

629659
type: Species
boundary condition: true
is: C00283
constant: false
name: H2S_s
has only substance units: false
is: CHEBI:16136
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3578
in compartment: 623935
initial concentration: 2.6E-4

733831
type: SpeciesReference
stoichiometry: 1.0
species: 629647

629647
type: Species
boundary condition: false
name: H2S_c
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3578
initial concentration: 2.6E-4
in compartment: 623911
constant: false
is: C00283
is: CHEBI:16136

807890
type: Reaction
is: ENSMUSG00000031904
product: 807938
product: 807950
name: r1909
reactant: 807902
reversible: false
reactant: 807914
notes: Y+LAT2 Utilized transport
product: 807962
reactant: 807926
fast: false

807938
type: SpeciesReference
stoichiometry: 1.0
species: 630798

630798
type: Species
is: http://identifiers.org/pubchem.compound/3697
in compartment: 623911
initial concentration: 2.6E-4
is: http://identifiers.org/cas/73-32-5
initial amount: NaN
is: C00407
is: CHEBI:17191
constant: false
has only substance units: false
boundary condition: true
name: Isoleucine_c

807950
type: SpeciesReference
stoichiometry: 1.0
species: 628543

807902
type: SpeciesReference
stoichiometry: 1.0
species: 630810

630810
type: Species
name: Isoleucine_s
is: http://identifiers.org/cas/73-32-5
is: C00407
in compartment: 623935
is: CHEBI:17191
boundary condition: true
initial amount: NaN
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3697
has only substance units: false
constant: false

807914
type: SpeciesReference
stoichiometry: 1.0
species: 628531

807962
type: SpeciesReference
stoichiometry: 1.0
species: 633079

807926
type: SpeciesReference
stoichiometry: 1.0
species: 633091

629107
type: Species
is: http://identifiers.org/pubchem.compound/10238
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Adenylyl_sulfate_c

633583
type: Species
in compartment: 623911
is: http://identifiers.org/pubchem.compound/5093
is: C01996
initial concentration: 2.6E-4
name: Acetylcholine_c
has only substance units: false
initial amount: NaN
constant: false
is: http://identifiers.org/cas/51-84-3
is: CHEBI:15355
boundary condition: false

832657
type: Reaction
reactant: 832681
product: 832729
product: 832717
is: ENSMUSG00000030236
fast: false
product: 832705
name: r2246
reactant: 832693
reversible: true
reactant: 832669
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

832681
type: SpeciesReference
stoichiometry: 1.0
species: 629719

832729
type: SpeciesReference
stoichiometry: 1.0
species: 639966

639966
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623935
name: S-glutathionyl-2-4-dinitrobenzene_s

832717
type: SpeciesReference
stoichiometry: 1.0
species: 629731

832705
type: SpeciesReference
stoichiometry: 1.0
species: 639594

639594
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/5240
constant: false
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/cas/71160-24-2
has only substance units: false
name: leukotriene-b4_c
initial concentration: 2.6E-4
is: C02165
is: CHEBI:15647

832693
type: SpeciesReference
stoichiometry: 1.0
species: 639954

639954
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: S-glutathionyl-2-4-dinitrobenzene_c

832669
type: SpeciesReference
stoichiometry: 1.0
species: 639606

639606
type: Species
has only substance units: false
constant: false
in compartment: 623935
is: CHEBI:15647
boundary condition: false
is: C02165
is: http://identifiers.org/pubchem.compound/5240
initial amount: NaN
name: leukotriene-b4_s
is: http://identifiers.org/cas/71160-24-2
initial concentration: 2.6E-4

665773
type: Constraint
message: Error: Species concentration 7alpha-Hydroxycholest-4-en-3-one_r is out of the hard bounds.

768570
type: Reaction
product: 768594
reactant: 768582
notes: Vesicular transport
fast: false
reversible: false
name: r1360

768594
type: SpeciesReference
stoichiometry: 1.0
species: 638538

638538
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: CDP-diacylglycerol-VLDL-PI-pool_r

768582
type: SpeciesReference
stoichiometry: 1.0
species: 638562

638562
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623851
name: CDP-diacylglycerol-VLDL-PI-pool_l

792125
type: Reaction
reactant: 792149
reactant: 792137
product: 792185
reactant: 792161
product: 792173
reversible: false
name: r1722
notes: Y+LAT2 Utilized transport
fast: false
is: ENSMUSG00000031904
product: 792197

792149
type: SpeciesReference
stoichiometry: 1.0
species: 626575

792137
type: SpeciesReference
stoichiometry: 1.0
species: 626311

626311
type: Species
initial amount: NaN
is: http://identifiers.org/cas/56-45-1
initial concentration: 2.6E-4
boundary condition: true
is: http://identifiers.org/pubchem.compound/3365
has only substance units: false
in compartment: 623935
name: Serine_s
is: C00065
is: CHEBI:17115
constant: false

792185
type: SpeciesReference
stoichiometry: 1.0
species: 626587

792161
type: SpeciesReference
stoichiometry: 1.0
species: 633091

792173
type: SpeciesReference
stoichiometry: 1.0
species: 626299

792197
type: SpeciesReference
stoichiometry: 1.0
species: 633079

843816
type: Reaction
fast: false
reversible: true
reactant: 843852
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: ENSMUSG00000050304
reactant: 843840
product: 843876
name: r2402
reactant: 843828
product: 843864
product: 843888

843852
type: SpeciesReference
stoichiometry: 1.0
species: 626647

626647
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-11
initial amount: NaN
in compartment: 623863
name: H+(PG)_m

843840
type: SpeciesReference
stoichiometry: 1.0
species: 630091

630091
type: Species
is: http://identifiers.org/cas/372-75-8
is: CHEBI:16349
constant: false
name: Citrulline_m
initial amount: NaN
is: C00327
has only substance units: false
is: http://identifiers.org/pubchem.compound/3621
in compartment: 623863
boundary condition: false
initial concentration: 2.6E-4

843876
type: SpeciesReference
stoichiometry: 1.0
species: 630067

630067
type: Species
is: CHEBI:16349
name: Citrulline_c
is: http://identifiers.org/cas/372-75-8
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3621
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
is: C00327
in compartment: 623911

843828
type: SpeciesReference
stoichiometry: 1.0
species: 626155

843864
type: SpeciesReference
stoichiometry: 1.0
species: 626191

626191
type: Species
has only substance units: false
name: Arginine_m
boundary condition: false
initial concentration: 2.6E-4
initial amount: NaN
is: http://identifiers.org/cas/74-79-3
constant: false
is: http://identifiers.org/pubchem.compound/3362
is: C00062
is: CHEBI:16467
in compartment: 623863

843888
type: SpeciesReference
stoichiometry: 1.0
species: 626623

626623
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-7
initial amount: NaN
in compartment: 623911
name: H+(PG)_c

668988
type: Constraint
message: Error: Species concentration Ceramide-pool_r is out of the hard bounds.

711401
type: Reaction
notes: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
product: 711449
product: 711461
name: r0541
reversible: true
reactant: 711425
is: ENSMUSG00000003809
reactant: 711413
product: 711437
is: K00252
is: R02487
fast: false

711449
type: SpeciesReference
stoichiometry: 1.0
species: 624883

711461
type: SpeciesReference
stoichiometry: 1.0
species: 630774

630774
type: Species
is: http://identifiers.org/cas/56275-39-9
boundary condition: false
in compartment: 623863
constant: false
is: CHEBI:17976
name: Ubiquinol_m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3680
is: C00390
initial concentration: 2.6E-4
has only substance units: false

711425
type: SpeciesReference
stoichiometry: 1.0
species: 630786

630786
type: Species
is: C00399
in compartment: 623863
is: http://identifiers.org/cas/1339-63-5
is: CHEBI:16389
name: Ubiquinone_m
initial concentration: 2.6E-4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3689
has only substance units: false
boundary condition: true
constant: false

711413
type: SpeciesReference
stoichiometry: 1.0
species: 631410

631410
type: Species
initial concentration: 2.6E-4
in compartment: 623863
boundary condition: false
is: http://identifiers.org/cas/103192-48-9
name: Glutaryl-CoA_m
initial amount: NaN
is: C00527
has only substance units: false
is: CHEBI:15524
is: http://identifiers.org/pubchem.compound/3810
constant: false

711437
type: SpeciesReference
stoichiometry: 1.0
species: 632299

632299
type: Species
is: CHEBI:15473
is: http://identifiers.org/cas/102680-35-3
name: Crotonyl-CoA_m
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0E-5
is: C00877
in compartment: 623863
has only substance units: false
is: http://identifiers.org/pubchem.compound/4133

720376
type: Reaction
is: K00149
is: K14085
is: ENSMUSG00000053644
product: 720436
is: ENSMUSG00000035561
is: R04506
notes: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is: K00128
reactant: 720400
is: ENSMUSG00000026687
reactant: 720388
is: ENSMUSG00000053279
is: ENSMUSG00000010025
product: 720424
reactant: 720412
reversible: true
fast: false
name: r0688

720436
type: SpeciesReference
stoichiometry: 1.0
species: 634735

634735
type: Species
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate_c
boundary condition: false
is: http://identifiers.org/pubchem.compound/7159
constant: false
initial amount: NaN
is: CHEBI:16577
is: C04554
in compartment: 623911
initial concentration: 2.6E-4

720400
type: SpeciesReference
stoichiometry: 1.0
species: 624403

720388
type: SpeciesReference
stoichiometry: 1.0
species: 635731

635731
type: Species
is: http://identifiers.org/pubchem.compound/7807
constant: false
initial amount: NaN
in compartment: 623911
initial concentration: 2.6E-4
is: C05445
has only substance units: false
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al_c
is: CHEBI:27428

720424
type: SpeciesReference
stoichiometry: 1.0
species: 624451

720412
type: SpeciesReference
stoichiometry: 1.0
species: 624259

722192
type: Reaction
name: r0717
is: K01692
is: K01782
is: K07511
notes: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: K01825
fast: false
is: R04738
product: 722228
is: K07514
reversible: true
reactant: 722204
is: K07515
is: K13767
product: 722216
is: ENSMUSG00000022853

722228
type: SpeciesReference
stoichiometry: 1.0
species: 624307

624307
type: Species
initial amount: NaN
name: H2O_p
initial concentration: 1.0
constant: false
is: CHEBI:15377
boundary condition: false
in compartment: 623899
has only substance units: false
is: http://identifiers.org/cas/7732-18-5
is: C00001
is: http://identifiers.org/pubchem.compound/3303

722204
type: SpeciesReference
stoichiometry: 1.0
species: 635155

722216
type: SpeciesReference
stoichiometry: 1.0
species: 635443

635443
type: Species
in compartment: 623899
name: (2E)-Hexadecenoyl-CoA_p
is: C05272
is: CHEBI:28935
is: http://identifiers.org/pubchem.compound/7659
initial concentration: 1.0E-5
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false

674988
type: Constraint
message: Error: Species concentration sulfochenodeoxycholate_s is out of the hard bounds.

785021
type: Reaction
fast: false
product: 785069
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: 785033
reactant: 785045
product: 785057
name: r1624
reversible: true
is: ENSMUSG00000040010

785069
type: SpeciesReference
stoichiometry: 1.0
species: 628711

628711
type: Species
is: C00188
is: CHEBI:16857
initial concentration: 2.6E-4
has only substance units: false
is: http://identifiers.org/pubchem.compound/3488
initial amount: NaN
in compartment: 623935
constant: false
boundary condition: true
is: http://identifiers.org/cas/72-19-5
name: Threonine_s

785033
type: SpeciesReference
stoichiometry: 1.0
species: 626587

785045
type: SpeciesReference
stoichiometry: 1.0
species: 628699

628699
type: Species
initial concentration: 2.6E-4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3488
is: CHEBI:16857
is: http://identifiers.org/cas/72-19-5
is: C00188
boundary condition: true
has only substance units: false
constant: false
name: Threonine_c
in compartment: 623911

785057
type: SpeciesReference
stoichiometry: 1.0
species: 626575

719068
type: Reaction
is: R04209
name: r0667
notes: 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase Purine metabolism EC:4.1.1.21
is: ENSMUSG00000029247
fast: false
is: K01587
product: 719104
reactant: 719080
reversible: true
is: K11808
product: 719092

719104
type: SpeciesReference
stoichiometry: 1.0
species: 624859

719080
type: SpeciesReference
stoichiometry: 1.0
species: 634939

634939
type: Species
initial amount: NaN
name: 5-Phosphoribosyl-4-carboxy-5-aminoimidazole_c
is: CHEBI:28413
is: http://identifiers.org/pubchem.compound/7321
initial concentration: 2.6E-4
has only substance units: false
constant: false
in compartment: 623911
is: C04751
boundary condition: false

719092
type: SpeciesReference
stoichiometry: 1.0
species: 634219

634219
type: Species
constant: false
is: CHEBI:28843
initial amount: NaN
name: AIR_c
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/25635-88-5
is: C03373
in compartment: 623911
boundary condition: false
is: http://identifiers.org/pubchem.compound/6208

658897
type: Constraint
message: Warning: Species concentration Porphobilinogen_c is out of the soft bounds.

766008
type: Reaction
product: 766248
product: 766116
product: 766284
product: 766176
product: 766092
notes: Protein degradation
product: 766272
name: r1352
product: 766260
reversible: false
product: 766296
reactant: 766032
product: 766056
fast: false
product: 766212
reactant: 766044
product: 766140
product: 766068
product: 766308
product: 766236
product: 766200
product: 766104
reactant: 766020
product: 766164
product: 766224
product: 766080
product: 766128
product: 766188
product: 766152

766248
type: SpeciesReference
stoichiometry: 56.0
species: 626299

766116
type: SpeciesReference
stoichiometry: 24.0
species: 627835

627835
type: Species
boundary condition: true
is: CHEBI:15971
initial amount: NaN
is: C00135
is: http://identifiers.org/pubchem.compound/3435
in compartment: 623911
name: Histidine_c
is: http://identifiers.org/cas/71-00-1
initial concentration: 2.6E-4
has only substance units: false
constant: false

766284
type: SpeciesReference
stoichiometry: 40.0
species: 628147

628147
type: Species
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3452
boundary condition: true
is: C00152
initial amount: NaN
is: CHEBI:17196
in compartment: 623911
is: http://identifiers.org/cas/70-47-3
has only substance units: false
name: Asparagine_c
constant: false

766176
type: SpeciesReference
stoichiometry: 31.0
species: 626251

626251
type: Species
name: Glutamine_c
is: http://identifiers.org/pubchem.compound/3364
is: C00064
is: http://identifiers.org/cas/56-85-9
has only substance units: false
initial amount: NaN
is: CHEBI:18050
initial concentration: 2.6E-4
constant: false
boundary condition: true
in compartment: 623911

766092
type: SpeciesReference
stoichiometry: 37.0
species: 625675

625675
type: Species
is: C00041
is: http://identifiers.org/cas/56-41-7
constant: false
boundary condition: true
is: CHEBI:16977
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3343
initial amount: NaN
name: Alanine_c
has only substance units: false
in compartment: 623911

766272
type: SpeciesReference
stoichiometry: 30.0
species: 626695

626695
type: Species
name: Tyrosine_c
is: C00082
initial amount: NaN
initial concentration: 2.6E-4
constant: false
boundary condition: true
is: http://identifiers.org/cas/60-18-4
in compartment: 623911
is: http://identifiers.org/pubchem.compound/3382
is: CHEBI:17895
has only substance units: false

766260
type: SpeciesReference
stoichiometry: 61.0
species: 628699

766296
type: SpeciesReference
stoichiometry: 36.0
species: 625867

625867
type: Species
is: CHEBI:17053
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3351
initial concentration: 5.5E-4
in compartment: 623911
constant: false
name: Aspartate_c
boundary condition: true
is: http://identifiers.org/cas/56-84-8
has only substance units: false
is: C00049

766032
type: SpeciesReference
stoichiometry: 1.0
species: 637099

637099
type: Species
is: P00747
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Plasminogen_c

766056
type: SpeciesReference
stoichiometry: 22.0
species: 630798

766212
type: SpeciesReference
stoichiometry: 62.0
species: 625627

766044
type: SpeciesReference
stoichiometry: 405.0
species: 624259

766140
type: SpeciesReference
stoichiometry: 48.0
species: 628531

766068
type: SpeciesReference
stoichiometry: 48.0
species: 627559

766308
type: SpeciesReference
stoichiometry: 49.0
species: 625819

766236
type: SpeciesReference
stoichiometry: 69.0
species: 628075

766200
type: SpeciesReference
stoichiometry: 48.0
species: 627007

766104
type: SpeciesReference
stoichiometry: 42.0
species: 626155

766020
type: SpeciesReference
stoichiometry: 405.0
species: 624331

766164
type: SpeciesReference
stoichiometry: 405.0
species: 624727

766224
type: SpeciesReference
stoichiometry: 21.0
species: 626575

766080
type: SpeciesReference
stoichiometry: 11.0
species: 626407

626407
type: Species
in compartment: 623911
constant: false
has only substance units: false
boundary condition: true
is: CHEBI:16643
is: http://identifiers.org/cas/63-68-3
is: C00073
initial concentration: 2.6E-4
initial amount: NaN
name: Methionine_c
is: http://identifiers.org/pubchem.compound/3373

766128
type: SpeciesReference
stoichiometry: 19.0
species: 626539

766188
type: SpeciesReference
stoichiometry: 56.0
species: 625291

625291
type: Species
constant: false
is: http://identifiers.org/cas/56-86-0
boundary condition: true
is: http://identifiers.org/pubchem.compound/3327
is: CHEBI:16015
is: C00025
name: Glutamate_c
has only substance units: false
initial amount: NaN
initial concentration: 0.015
in compartment: 623911

766152
type: SpeciesReference
stoichiometry: 405.0
species: 624655

773515
type: Reaction
fast: false
name: r1445
is: ENSMUSG00000020777
reversible: false
notes: EC:1.3.3.6
reactant: 773527
product: 773563
product: 773551
is: ENSMUSG00000029098
reactant: 773539

773527
type: SpeciesReference
stoichiometry: 1.0
species: 624631

624631
type: Species
is: http://identifiers.org/cas/7782-44-7
initial amount: NaN
is: C00007
is: http://identifiers.org/pubchem.compound/3309
in compartment: 623899
boundary condition: false
is: CHEBI:15379
has only substance units: false
constant: false
name: O2_p
initial concentration: 5.05E-5

773563
type: SpeciesReference
stoichiometry: 1.0
species: 625423

625423
type: Species
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
constant: false
is: http://identifiers.org/pubchem.compound/3329
is: http://identifiers.org/cas/7722-84-1
name: H2O2_p
is: CHEBI:16240
is: C00027
initial amount: NaN
in compartment: 623899

773551
type: SpeciesReference
stoichiometry: 1.0
species: 635515

635515
type: Species
has only substance units: false
is: C05275
initial concentration: 1.0E-5
constant: false
boundary condition: false
in compartment: 623899
initial amount: NaN
is: CHEBI:10723
name: (2E)-Decenoyl-CoA_p
is: http://identifiers.org/pubchem.compound/7662

773539
type: SpeciesReference
stoichiometry: 1.0
species: 635491

635491
type: Species
name: Decanoyl-CoA_p
boundary condition: false
is: http://identifiers.org/pubchem.compound/7661
is: C05274
initial amount: NaN
constant: false
is: CHEBI:28493
in compartment: 623899
has only substance units: false
initial concentration: 2.6E-4

628903
type: Species
is: C00208
initial concentration: 2.6E-4
in compartment: 623935
is: CHEBI:17306
is: http://identifiers.org/cas/69-79-4
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3508
boundary condition: true
has only substance units: false
name: Maltose_s

648818
type: Constraint
message: Warning: Species concentration Choline_c is out of the soft bounds.

626743
type: Species
constant: false
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3383
is: http://identifiers.org/cas/524-14-1
initial amount: NaN
is: CHEBI:15531
name: Malonyl-CoA_r
initial concentration: 2.6E-4
is: C00083
in compartment: 623923

640434
type: Species
in compartment: 623935
name: prostaglandin-i2_s
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/4527
is: http://identifiers.org/cas/35121-78-9
is: CHEBI:15552
initial amount: NaN
constant: false
boundary condition: false
is: C01312

729871
type: Reaction
product: 729895
reactant: 729883
notes: Free diffusion
fast: false
reversible: true
name: r0857

729895
type: SpeciesReference
stoichiometry: 1.0
species: 624595

729883
type: SpeciesReference
stoichiometry: 1.0
species: 624631

673152
type: Constraint
message: Warning: Species concentration 20-hydroxy-arachidonate_s is out of the soft bounds.

679319
type: Reaction
reactant: 679343
fast: false
is: R00115
name: r0025
reactant: 679331
product: 679355
is: ENSMUSG00000031584
notes: glutathione:NADP+ oxidoreductase Glutamate metabolism / Glutathione metabolism EC:1.8.1.7
product: 679367
is: K00383
reversible: true

679343
type: SpeciesReference
stoichiometry: 1.0
species: 624547

624547
type: Species
constant: false
name: NADP+_c
boundary condition: false
initial amount: NaN
is: C00006
in compartment: 623911
has only substance units: false
initial concentration: 1.0E-4
is: http://identifiers.org/pubchem.compound/3308
is: http://identifiers.org/cas/53-59-8
is: CHEBI:18009

679331
type: SpeciesReference
stoichiometry: 2.0
species: 625915

625915
type: Species
initial concentration: 2.6E-4
is: http://identifiers.org/cas/70-18-8
name: GSH_c
boundary condition: false
in compartment: 623911
constant: false
is: http://identifiers.org/pubchem.compound/3353
has only substance units: false
is: CHEBI:16856
is: C00051
initial amount: NaN

679355
type: SpeciesReference
stoichiometry: 1.0
species: 627655

627655
type: Species
initial concentration: 2.6E-4
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3427
in compartment: 623911
is: http://identifiers.org/cas/27025-41-8
initial amount: NaN
is: CHEBI:17858
is: C00127
boundary condition: false
name: GSSG_c

679367
type: SpeciesReference
stoichiometry: 1.0
species: 624499

624499
type: Species
is: C00005
boundary condition: true
name: NADPH_c
has only substance units: false
is: http://identifiers.org/pubchem.compound/3307
is: CHEBI:16474
initial amount: NaN
in compartment: 623911
is: http://identifiers.org/cas/2646-71-1
constant: false
initial concentration: 5.1E-5

643230
type: Constraint
message: Warning: Species concentration O2_c is out of the soft bounds.

841260
type: Reaction
product: 841284
reactant: 841272
notes: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
name: r2365

841284
type: SpeciesReference
stoichiometry: 1.0
species: 640302

640302
type: Species
name: prostaglandin-f1alpha_c
constant: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/8707
is: C06475
is: CHEBI:28852
initial amount: NaN
has only substance units: false
is: http://identifiers.org/cas/745-62-0
boundary condition: false
in compartment: 623911

841272
type: SpeciesReference
stoichiometry: 1.0
species: 640314

640314
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/8707
initial concentration: 2.6E-4
is: CHEBI:28852
name: prostaglandin-f1alpha_s
boundary condition: false
initial amount: NaN
is: http://identifiers.org/cas/745-62-0
is: C06475
has only substance units: false
in compartment: 623935

702915
type: Reaction
product: 702939
reactant: 702927
notes: D-Mannose-6-phosphate ketol-isomerase EC:5.3.1.8
is: R00772
is: ENSMUSG00000032306
fast: false
reversible: true
name: r0405

702939
type: SpeciesReference
stoichiometry: 1.0
species: 626815

626815
type: Species
name: Fructose-6P_c
is: http://identifiers.org/pubchem.compound/3385
has only substance units: false
constant: false
is: http://identifiers.org/cas/643-13-0
is: CHEBI:15946
is: C00085
in compartment: 623911
initial concentration: 4.0E-4
initial amount: NaN
boundary condition: false

702927
type: SpeciesReference
stoichiometry: 1.0
species: 629623

629623
type: Species
is: C00275
is: http://identifiers.org/pubchem.compound/3572
is: CHEBI:17369
name: Mannose-6P_c
has only substance units: false
initial concentration: 2.6E-4
boundary condition: false
in compartment: 623911
constant: false
initial amount: NaN

643650
type: Constraint
message: Error: Species concentration CoA_m is out of the hard bounds.

645149
type: Constraint
message: Warning: Species concentration Acetate_m is out of the soft bounds.

656018
type: Constraint
message: Warning: Species concentration 5-Aminolevulinate_m is out of the soft bounds.

688194
type: Reaction
name: r0166
reactant: 688206
product: 688230
product: 688242
reactant: 688218
is: R00662
notes: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
is: K02428
is: K04765
fast: false
is: K01519
reversible: false
is: ENSMUSG00000074797

688206
type: SpeciesReference
stoichiometry: 1.0
species: 626491

688230
type: SpeciesReference
stoichiometry: 1.0
species: 624931

624931
type: Species
is: CHEBI:18361
initial concentration: 1.0E-8
is: http://identifiers.org/pubchem.compound/3315
is: http://identifiers.org/cas/2466-09-3
name: PPi_s
is: C00013
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
in compartment: 623935

688242
type: SpeciesReference
stoichiometry: 1.0
species: 627223

627223
type: Species
in compartment: 623935
is: http://identifiers.org/cas/58-97-9
initial concentration: 2.6E-4
is: CHEBI:16695
initial amount: NaN
name: UMP_s
is: C00105
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3405
boundary condition: true

688218
type: SpeciesReference
stoichiometry: 1.0
species: 624271

624271
type: Species
is: CHEBI:15377
has only substance units: false
name: H2O_s
initial concentration: 1.0
constant: false
initial amount: NaN
is: C00001
is: http://identifiers.org/pubchem.compound/3303
is: http://identifiers.org/cas/7732-18-5
in compartment: 623935
boundary condition: false

669792
type: Constraint
message: Warning: Species concentration Cholesterol-ester-ol_l is out of the soft bounds.

662281
type: Constraint
message: Warning: Species concentration (2E)-Dodecenoyl-CoA_m is out of the soft bounds.

636139
type: Species
constant: false
is: CHEBI:2070
initial amount: NaN
has only substance units: false
in compartment: 623911
is: http://identifiers.org/pubchem.compound/7945
name: 5-Hydroxyindoleacetaldehyde_c
initial concentration: 2.6E-4
is: C05634
boundary condition: false

673944
type: Constraint
message: Warning: Species concentration glutathionyl-leuc4_s is out of the soft bounds.

663997
type: Constraint
message: Error: Species concentration 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoyl-CoA_p is out of the hard bounds.

667320
type: Constraint
message: Warning: Species concentration Propinol_adenylate_c is out of the soft bounds.

761473
type: Reaction
product: 761641
fast: false
product: 761545
product: 761773
product: 761557
product: 761521
product: 761725
reactant: 761497
notes: Protein degradation
product: 761533
product: 761701
product: 761761
product: 761593
reactant: 761509
product: 761617
name: r1337
product: 761749
product: 761713
product: 761629
product: 761677
product: 761581
product: 761605
product: 761689
product: 761653
product: 761737
reversible: false
reactant: 761485
product: 761665
product: 761569

761641
type: SpeciesReference
stoichiometry: 18.0
species: 626251

761545
type: SpeciesReference
stoichiometry: 10.0
species: 626407

761773
type: SpeciesReference
stoichiometry: 34.0
species: 625819

761557
type: SpeciesReference
stoichiometry: 26.0
species: 625675

761521
type: SpeciesReference
stoichiometry: 20.0
species: 630798

761725
type: SpeciesReference
stoichiometry: 30.0
species: 628699

761497
type: SpeciesReference
stoichiometry: 209.0
species: 624259

761533
type: SpeciesReference
stoichiometry: 51.0
species: 627559

761701
type: SpeciesReference
stoichiometry: 19.0
species: 628075

761761
type: SpeciesReference
stoichiometry: 24.0
species: 625867

761593
type: SpeciesReference
stoichiometry: 3.0
species: 626539

761509
type: SpeciesReference
stoichiometry: 1.0
species: 624019

624019
type: Species
is: P01009
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Antitrypsin_c

761617
type: SpeciesReference
stoichiometry: 209.0
species: 624655

761749
type: SpeciesReference
stoichiometry: 19.0
species: 628147

761713
type: SpeciesReference
stoichiometry: 25.0
species: 626299

761629
type: SpeciesReference
stoichiometry: 209.0
species: 624727

761677
type: SpeciesReference
stoichiometry: 24.0
species: 625627

761581
type: SpeciesReference
stoichiometry: 13.0
species: 627835

761605
type: SpeciesReference
stoichiometry: 27.0
species: 628531

761689
type: SpeciesReference
stoichiometry: 27.0
species: 626575

761653
type: SpeciesReference
stoichiometry: 32.0
species: 625291

761737
type: SpeciesReference
stoichiometry: 6.0
species: 626695

761485
type: SpeciesReference
stoichiometry: 209.0
species: 624331

761665
type: SpeciesReference
stoichiometry: 3.0
species: 627007

761569
type: SpeciesReference
stoichiometry: 7.0
species: 626155

731947
type: Reaction
product: 731971
reactant: 731959
notes: GLUT-8 Transport reaction
is: ENSMUSG00000026791
fast: false
reversible: true
name: r0898

731971
type: SpeciesReference
stoichiometry: 1.0
species: 626971

626971
type: Species
boundary condition: false
is: http://identifiers.org/cas/57-48-7
is: http://identifiers.org/pubchem.compound/3395
name: Fructose_c
is: CHEBI:15824
initial concentration: 2.6E-4
is: C00095
in compartment: 623911
initial amount: NaN
has only substance units: false
constant: false

731959
type: SpeciesReference
stoichiometry: 1.0
species: 626983

626983
type: Species
initial amount: NaN
has only substance units: false
name: Fructose_s
is: http://identifiers.org/pubchem.compound/3395
is: http://identifiers.org/cas/57-48-7
in compartment: 623935
initial concentration: 2.6E-4
is: CHEBI:15824
boundary condition: true
constant: false
is: C00095

638166
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Phosphatidate-VLDL-PC-pool_c

661417
type: Constraint
message: Warning: Species concentration Protoporphyrin_m is out of the soft bounds.

677687
type: Constraint
message: Warning: Species concentration CoA-activated_acetyl_group_c is out of the soft bounds.

665509
type: Constraint
message: Error: Species concentration 5beta-Cholestane-3alpha,7alpha,26-triol_m is out of the hard bounds.

642594
type: Constraint
message: Error: Species concentration H2O_l is out of the hard bounds.

664633
type: Constraint
message: Warning: Species concentration 3-Oxododecanoyl-CoA_p is out of the soft bounds.

634795
type: Species
initial concentration: 2.6E-4
boundary condition: false
has only substance units: false
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7209
is: C04619
name: (R)-3-Hydroxydecanoyl-ACP_c
constant: false

746747
type: Reaction
product: 746783
fast: false
notes: Major Facilitator(MFS) TCDB:2.A.18.6.5
reactant: 746771
reversible: true
is: ENSMUSG00000022462
name: r1119
product: 746795
reactant: 746759

746783
type: SpeciesReference
stoichiometry: 1.0
species: 626263

626263
type: Species
is: CHEBI:18050
name: Glutamine_s
is: http://identifiers.org/pubchem.compound/3364
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623935
boundary condition: true
is: http://identifiers.org/cas/56-85-9
is: C00064
has only substance units: false
constant: false

746771
type: SpeciesReference
stoichiometry: 1.0
species: 633079

746795
type: SpeciesReference
stoichiometry: 1.0
species: 633091

746759
type: SpeciesReference
stoichiometry: 1.0
species: 626251

638934
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623911
name: NADH-redox-potential_c

716368
type: Reaction
is: K00136
product: 716416
is: R03381
fast: false
reversible: true
reactant: 716392
is: ENSMUSG00000021238
product: 716428
notes: 3-Oxopropanoate:NAD+ oxidoreductase (decarboxylating, CoA-acetylating) Propanoate metabolism EC:1.2.1.18
reactant: 716380
reactant: 716404
name: r0624

716416
type: SpeciesReference
stoichiometry: 1.0
species: 633007

633007
type: Species
in compartment: 623863
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/4435
boundary condition: false
is: CHEBI:15465
constant: false
has only substance units: false
initial amount: NaN
name: (R)-Methylmalonyl-CoA_m
is: C01213

716392
type: SpeciesReference
stoichiometry: 1.0
species: 624811

716428
type: SpeciesReference
stoichiometry: 1.0
species: 624463

716380
type: SpeciesReference
stoichiometry: 1.0
species: 630331

630331
type: Species
name: 2-Methyl-3-oxopropanoate_m
is: http://identifiers.org/pubchem.compound/3642
boundary condition: false
is: C00349
initial amount: NaN
has only substance units: false
initial concentration: 2.6E-4
is: CHEBI:16256
constant: false
in compartment: 623863

716404
type: SpeciesReference
stoichiometry: 1.0
species: 624415

630211
type: Species
is: http://identifiers.org/cas/56-12-2
boundary condition: false
is: CHEBI:16865
is: C00334
has only substance units: false
initial concentration: 2.6E-4
in compartment: 623911
is: http://identifiers.org/pubchem.compound/3628
initial amount: NaN
constant: false
name: 4-Aminobutyrate_c

680603
type: Reaction
fast: false
is: K08722
is: K03787
is: K01081
is: ENSMUSG00000032420
reactant: 680627
is: R00183
is: K08723
product: 680651
notes: Adenosine 5'-monophosphate phosphohydrolase Purine metabolism EC:3.1.3.5
name: r0046
reactant: 680615
product: 680639
is: K11751
reversible: false

680627
type: SpeciesReference
stoichiometry: 1.0
species: 624271

680651
type: SpeciesReference
stoichiometry: 1.0
species: 628951

628951
type: Species
is: http://identifiers.org/cas/58-61-7
is: http://identifiers.org/pubchem.compound/3512
constant: false
name: Adenosine_s
initial concentration: 2.6E-4
is: CHEBI:16335
is: C00212
initial amount: NaN
boundary condition: true
has only substance units: false
in compartment: 623935

680615
type: SpeciesReference
stoichiometry: 1.0
species: 625147

625147
type: Species
name: AMP_s
is: C00020
has only substance units: false
constant: false
initial concentration: 4.2E-4
is: CHEBI:16027
boundary condition: true
is: http://identifiers.org/cas/61-19-8
initial amount: NaN
in compartment: 623935
is: http://identifiers.org/pubchem.compound/3322

680639
type: SpeciesReference
stoichiometry: 1.0
species: 624739

624739
type: Species
has only substance units: false
is: http://identifiers.org/cas/7664-38-2
initial concentration: 0.056
is: CHEBI:18367
is: http://identifiers.org/pubchem.compound/3311
initial amount: NaN
in compartment: 623935
name: Pi_s
boundary condition: true
constant: false
is: C00009

679187
type: Reaction
name: r0023
reactant: 679211
is: K00326
is: R00100
is: ENSMUSG00000026456
is: ENSMUSG00000048065
reactant: 679199
fast: false
product: 679235
notes: NADH:ferricytochrome-b5 oxidoreductase Aminosugars metabolism EC:1.6.2.2
product: 679223
reversible: true
is: ENSMUSG00000018042

679211
type: SpeciesReference
stoichiometry: 2.0
species: 632491

632491
type: Species
is: P56395
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Ferricytochrome_b5_c

679199
type: SpeciesReference
stoichiometry: 1.0
species: 624451

679235
type: SpeciesReference
stoichiometry: 2.0
species: 632503

632503
type: Species
is: P56395
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Ferrocytochrome_b5_c

679223
type: SpeciesReference
stoichiometry: 1.0
species: 624403

644585
type: Constraint
message: Error: Species concentration Acetyl-CoA_p is out of the hard bounds.

665401
type: Constraint
message: Warning: Species concentration Galactosylglycerol_s is out of the soft bounds.

643110
type: Constraint
message: Warning: Species concentration NADP+_r is out of the soft bounds.

677435
type: Constraint
message: Error: Species concentration UDP-activated-glucuronate_c is out of the hard bounds.

628519
type: Species
boundary condition: false
name: Agmatine_m
is: CHEBI:17431
is: C00179
initial concentration: 2.6E-4
constant: false
initial amount: NaN
has only substance units: false
in compartment: 623863
is: http://identifiers.org/pubchem.compound/3479
is: http://identifiers.org/cas/306-60-5

648230
type: Constraint
message: Error: Species concentration beta-Alanine_m is out of the hard bounds.

661813
type: Constraint
message: Error: Species concentration O-Acetylcarnitine_m is out of the hard bounds.

852328
type: Reaction
product: 852354
reactant: 852341
notes: Utilized transport
fast: false
reversible: true
name: r2538

852354
type: SpeciesReference
stoichiometry: 1.0
species: 638838

638838
type: Species
boundary condition: false
is: C03595
constant: false
name: Dihomo-gamma-linolenoyl-CoA_r
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6386
is: CHEBI:27979
has only substance units: false
in compartment: 623923
initial concentration: 2.6E-4

852341
type: SpeciesReference
stoichiometry: 1.0
species: 638850

638850
type: Species
is: CHEBI:27979
constant: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
is: C03595
name: Dihomo-gamma-linolenoyl-CoA_c
is: http://identifiers.org/pubchem.compound/6386
in compartment: 623911
boundary condition: false

717760
type: Reaction
is: K01556
fast: false
is: ENSMUSG00000026866
product: 717808
is: R03936
product: 717796
reversible: true
name: r0646
reactant: 717772
notes: Formylkynurenine hydrolase Tryptophan metabolism EC:3.7.1.3
reactant: 717784

717808
type: SpeciesReference
stoichiometry: 1.0
species: 625675

717796
type: SpeciesReference
stoichiometry: 1.0
species: 636175

636175
type: Species
initial concentration: 2.6E-4
is: C05653
constant: false
in compartment: 623911
boundary condition: false
is: CHEBI:36575
is: http://identifiers.org/pubchem.compound/7964
initial amount: NaN
is: http://identifiers.org/cas/3342-77-6
name: Formylanthranilate_c
has only substance units: false

717772
type: SpeciesReference
stoichiometry: 1.0
species: 633931

633931
type: Species
is: http://identifiers.org/cas/1022-31-7
is: http://identifiers.org/pubchem.compound/5664
has only substance units: false
initial amount: NaN
is: CHEBI:30249
is: C02700
initial concentration: 2.6E-4
constant: false
boundary condition: false
name: L-Formylkynurenine_c
in compartment: 623911

717784
type: SpeciesReference
stoichiometry: 1.0
species: 624259

643770
type: Constraint
message: Error: Species concentration CO2_s is out of the hard bounds.

747827
type: Reaction
name: r1139
is: ENSMUSG00000022462
notes: Major Facilitator(MFS) TCDB:2.A.18.6.5
reversible: true
product: 747875
fast: false
reactant: 747839
product: 747863
reactant: 747851

747875
type: SpeciesReference
stoichiometry: 1.0
species: 633091

747839
type: SpeciesReference
stoichiometry: 1.0
species: 628075

747863
type: SpeciesReference
stoichiometry: 1.0
species: 628087

747851
type: SpeciesReference
stoichiometry: 1.0
species: 633079

839208
type: Reaction
product: 839268
is: ENSMUSG00000032548
product: 839256
reactant: 839232
reactant: 839244
reactant: 839220
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: 839280
fast: false
reversible: true
name: r2324

839268
type: SpeciesReference
stoichiometry: 1.0
species: 629731

839256
type: SpeciesReference
stoichiometry: 1.0
species: 640134

839232
type: SpeciesReference
stoichiometry: 1.0
species: 629719

839244
type: SpeciesReference
stoichiometry: 1.0
species: 625915

839220
type: SpeciesReference
stoichiometry: 1.0
species: 640146

839280
type: SpeciesReference
stoichiometry: 1.0
species: 625927

625927
type: Species
is: http://identifiers.org/cas/70-18-8
in compartment: 623935
is: C00051
constant: false
is: http://identifiers.org/pubchem.compound/3353
boundary condition: true
is: CHEBI:16856
initial amount: NaN
initial concentration: 2.6E-4
name: GSH_s
has only substance units: false

645761
type: Constraint
message: Error: Species concentration Aspartate_c is out of the hard bounds.

703016
type: Reaction
is: ENSMUSG00000017390
is: ENSMUSG00000028307
reversible: true
is: K01623
is: R01829
product: 703042
is: ENSMUSG00000030695
is: K01624
product: 703055
fast: false
reactant: 703029
notes: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
name: r0407

703042
type: SpeciesReference
stoichiometry: 1.0
species: 627295

627295
type: Species
initial concentration: 0.002505
in compartment: 623911
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
is: C00111
name: DHAP_c
is: CHEBI:16108
has only substance units: false
initial amount: NaN
constant: false

703055
type: SpeciesReference
stoichiometry: 1.0
species: 629635

629635
type: Species
is: C00279
has only substance units: false
is: CHEBI:48153
is: http://identifiers.org/cas/585-18-2
is: http://identifiers.org/pubchem.compound/3574
constant: false
in compartment: 623911
name: Erythrose-4P_c
boundary condition: false
initial amount: NaN
initial concentration: 2.6E-4

703029
type: SpeciesReference
stoichiometry: 1.0
species: 631038

631038
type: Species
is: C00447
is: http://identifiers.org/pubchem.compound/3735
in compartment: 623911
is: CHEBI:17969
initial amount: NaN
initial concentration: 2.6E-4
constant: false
boundary condition: false
has only substance units: false
name: Sedoheptulose-1,7PP_c

631470
type: Species
is: http://identifiers.org/pubchem.compound/3818
initial concentration: 2.6E-4
boundary condition: true
has only substance units: false
is: C00536
name: Triphosphate_c
is: CHEBI:18036
constant: false
initial amount: NaN
in compartment: 623911

700540
type: Reaction
fast: false
reactant: 700564
is: K00648
is: R01624
reactant: 700552
product: 700576
is: K00668
notes: acetyl-CoA:[acyl-carrier-protein] S-acetyltransferase Fatty acid biosynthesis EC:2.3.1.85
is: K00665
name: r0367
reversible: true
is: ENSMUSG00000025153
product: 700588
is: K11533

700564
type: SpeciesReference
stoichiometry: 1.0
species: 629119

629119
type: Species
is: C00229
is: http://identifiers.org/pubchem.compound/3528
name: ACP_c
boundary condition: false
in compartment: 623911
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 2.6E-4

700552
type: SpeciesReference
stoichiometry: 1.0
species: 625255

700576
type: SpeciesReference
stoichiometry: 1.0
species: 624799

700588
type: SpeciesReference
stoichiometry: 1.0
species: 634507

634507
type: Species
name: Acetyl-ACP_c
is: C03939
initial amount: NaN
boundary condition: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/6663
has only substance units: false
constant: false
in compartment: 623911

773695
type: Reaction
reactant: 773707
fast: false
reactant: 773719
product: 773743
is: ENSMUSG00000020777
notes: EC:1.3.3.6
reversible: false
is: ENSMUSG00000029098
name: r1448
product: 773731

773707
type: SpeciesReference
stoichiometry: 1.0
species: 630786

773719
type: SpeciesReference
stoichiometry: 1.0
species: 633547

633547
type: Species
is: http://identifiers.org/pubchem.compound/5048
initial amount: NaN
has only substance units: false
initial concentration: 2.6E-4
constant: false
is: C01944
boundary condition: false
name: Octanoyl-CoA_m
in compartment: 623863
is: CHEBI:15533

773743
type: SpeciesReference
stoichiometry: 1.0
species: 630774

773731
type: SpeciesReference
stoichiometry: 1.0
species: 635527

635527
type: Species
is: C05276
initial concentration: 1.0E-5
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/7663
name: (2E)-Octenoyl-CoA_m
initial amount: NaN
in compartment: 623863
constant: false
is: CHEBI:27537

653582
type: Constraint
message: Error: Species concentration Inosine_c is out of the hard bounds.

685997
type: Reaction
is: K00955
is: ENSMUSG00000028032
product: 686033
reactant: 686009
reversible: false
is: K00860
reactant: 686021
is: K13811
is: R00509
fast: false
notes: ATP:adenylylsulfate 3'-phosphotransferase Purine metabolism / Sulfur metabolism EC:2.7.1.25
product: 686045
name: r0133
is: ENSMUSG00000024899

686033
type: SpeciesReference
stoichiometry: 1.0
species: 624655

686009
type: SpeciesReference
stoichiometry: 1.0
species: 624331

686021
type: SpeciesReference
stoichiometry: 1.0
species: 629107

686045
type: SpeciesReference
stoichiometry: 1.0
species: 625975

625975
type: Species
is: CHEBI:17980
constant: false
is: http://identifiers.org/pubchem.compound/3355
initial concentration: 2.6E-4
in compartment: 623911
has only substance units: false
name: PAPS_c
is: C00053
is: http://identifiers.org/cas/482-67-7
initial amount: NaN
boundary condition: true

730327
type: Reaction
product: 730351
reactant: 730339
notes: Free diffusion
fast: false
reversible: true
name: r0867

730351
type: SpeciesReference
stoichiometry: 1.0
species: 624871

624871
type: Species
boundary condition: true
in compartment: 623935
is: C00011
is: http://identifiers.org/cas/124-38-9
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3313
name: CO2_s
has only substance units: false
is: CHEBI:16526
initial concentration: 0.025

730339
type: SpeciesReference
stoichiometry: 1.0
species: 624859

648530
type: Constraint
message: Warning: Species concentration UMP_s is out of the soft bounds.

645017
type: Constraint
message: Error: Species concentration Glucose_s is out of the hard bounds.

887500
type: Reaction
product: 887764
product: 887596
reactant: 887536
product: 887548
product: 887752
product: 887704
name: r2647
fast: false
product: 887692
product: 887680
product: 887608
product: 887776
reactant: 887512
product: 887788
product: 887632
product: 887800
product: 887728
product: 887584
product: 887620
product: 887716
reversible: false
product: 887740
product: 887572
reactant: 887524
notes: Protein degradation
product: 887668
product: 887560
product: 887644
product: 887656

887764
type: SpeciesReference
stoichiometry: 10.0
species: 626539

887596
type: SpeciesReference
stoichiometry: 11.0
species: 626575

887536
type: SpeciesReference
stoichiometry: 149.5
species: 624259

887548
type: SpeciesReference
stoichiometry: 20.0
species: 625675

887752
type: SpeciesReference
stoichiometry: 13.0
species: 628531

887704
type: SpeciesReference
stoichiometry: 10.0
species: 626251

887692
type: SpeciesReference
stoichiometry: 23.0
species: 628075

887680
type: SpeciesReference
stoichiometry: 12.0
species: 628147

887608
type: SpeciesReference
stoichiometry: 38.0
species: 625627

887776
type: SpeciesReference
stoichiometry: 10.0
species: 626695

887512
type: SpeciesReference
stoichiometry: 1.0
species: 641538

641538
type: Species
is: O75636
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_FCN3_c

887788
type: SpeciesReference
stoichiometry: 149.5
species: 624655

887632
type: SpeciesReference
stoichiometry: 3.0
species: 630798

887800
type: SpeciesReference
stoichiometry: 149.5
species: 624727

887728
type: SpeciesReference
stoichiometry: 23.0
species: 626299

887584
type: SpeciesReference
stoichiometry: 18.0
species: 625291

887620
type: SpeciesReference
stoichiometry: 10.0
species: 627835

887716
type: SpeciesReference
stoichiometry: 20.0
species: 626155

887740
type: SpeciesReference
stoichiometry: 9.0
species: 628699

887572
type: SpeciesReference
stoichiometry: 13.0
species: 625867

887524
type: SpeciesReference
stoichiometry: 149.5
species: 624331

887668
type: SpeciesReference
stoichiometry: 5.0
species: 626407

887560
type: SpeciesReference
stoichiometry: 9.0
species: 627007

887644
type: SpeciesReference
stoichiometry: 7.0
species: 625819

887656
type: SpeciesReference
stoichiometry: 35.0
species: 627559

868410
type: Reaction
product: 868458
product: 868698
product: 868686
reactant: 868446
product: 868626
product: 868710
product: 868554
name: r2589
product: 868650
product: 868614
product: 868542
product: 868530
fast: false
notes: Protein degradation
product: 868470
product: 868578
reactant: 868434
product: 868674
product: 868662
product: 868518
reversible: false
product: 868590
product: 868566
product: 868506
product: 868494
product: 868482
reactant: 868422
product: 868638
product: 868602

868458
type: SpeciesReference
stoichiometry: 33.0
species: 625675

868698
type: SpeciesReference
stoichiometry: 372.0
species: 624655

868686
type: SpeciesReference
stoichiometry: 22.0
species: 626695

868446
type: SpeciesReference
stoichiometry: 372.0
species: 624259

868626
type: SpeciesReference
stoichiometry: 13.0
species: 626155

868710
type: SpeciesReference
stoichiometry: 372.0
species: 624727

868554
type: SpeciesReference
stoichiometry: 47.0
species: 625819

868650
type: SpeciesReference
stoichiometry: 8.0
species: 628699

868614
type: SpeciesReference
stoichiometry: 38.0
species: 626251

868542
type: SpeciesReference
stoichiometry: 33.0
species: 630798

868530
type: SpeciesReference
stoichiometry: 11.0
species: 627835

868470
type: SpeciesReference
stoichiometry: 2.0
species: 627007

868578
type: SpeciesReference
stoichiometry: 23.0
species: 626407

868434
type: SpeciesReference
stoichiometry: 372.0
species: 624331

868674
type: SpeciesReference
stoichiometry: 1.0
species: 626539

868662
type: SpeciesReference
stoichiometry: 30.0
species: 628531

868518
type: SpeciesReference
stoichiometry: 190.0
species: 625627

868590
type: SpeciesReference
stoichiometry: 8.0
species: 628147

868566
type: SpeciesReference
stoichiometry: 53.0
species: 627559

868506
type: SpeciesReference
stoichiometry: 17.0
species: 626575

868494
type: SpeciesReference
stoichiometry: 26.0
species: 625291

868482
type: SpeciesReference
stoichiometry: 11.0
species: 625867

868422
type: SpeciesReference
stoichiometry: 1.0
species: 641190

641190
type: Species
is: P27658
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CO8A1_c

868638
type: SpeciesReference
stoichiometry: 11.0
species: 626299

868602
type: SpeciesReference
stoichiometry: 167.0
species: 628075

830327
type: Reaction
reactant: 830363
reversible: true
product: 830399
product: 830387
reactant: 830351
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
name: r2219
product: 830375
fast: false
is: ENSMUSG00000030236
reactant: 830339

830363
type: SpeciesReference
stoichiometry: 1.0
species: 639954

830399
type: SpeciesReference
stoichiometry: 1.0
species: 639966

830387
type: SpeciesReference
stoichiometry: 1.0
species: 629731

830351
type: SpeciesReference
stoichiometry: 1.0
species: 629719

830375
type: SpeciesReference
stoichiometry: 1.0
species: 629047

629047
type: Species
is: http://identifiers.org/pubchem.compound/3519
is: C00219
initial amount: NaN
is: http://identifiers.org/cas/506-32-1
constant: false
has only substance units: false
boundary condition: false
in compartment: 623911
initial concentration: 2.6E-4
is: CHEBI:15843
name: Arachidonate_c

830339
type: SpeciesReference
stoichiometry: 1.0
species: 629059

629059
type: Species
in compartment: 623935
constant: false
name: Arachidonate_s
is: CHEBI:15843
is: C00219
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3519
boundary condition: true
is: http://identifiers.org/cas/506-32-1
initial amount: NaN

636295
type: Species
has only substance units: false
initial concentration: 2.6E-4
is: C05751
in compartment: 623911
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/8046
name: (2E)-Octenoyl-ACP_c
constant: false

711017
type: Reaction
reversible: true
is: R02396
reactant: 711029
name: r0534
product: 711053
fast: false
product: 711065
is: K00624
reactant: 711041
is: ENSMUSG00000026853
notes: Acetyl-CoA:carnitine O-acetyltransferase Alanine and aspartate metabolism EC:2.3.1.7

711029
type: SpeciesReference
stoichiometry: 1.0
species: 625255

711053
type: SpeciesReference
stoichiometry: 1.0
species: 624799

711065
type: SpeciesReference
stoichiometry: 1.0
species: 633859

633859
type: Species
is: C02571
is: http://identifiers.org/pubchem.compound/5567
has only substance units: false
initial amount: NaN
initial concentration: 2.6E-4
constant: false
name: O-Acetylcarnitine_c
is: CHEBI:15960
boundary condition: false
in compartment: 623911

711041
type: SpeciesReference
stoichiometry: 1.0
species: 629983

629983
type: Species
is: C00318
is: http://identifiers.org/pubchem.compound/3612
boundary condition: false
name: L-Carnitine_c
has only substance units: false
in compartment: 623911
initial concentration: 2.6E-4
is: CHEBI:16347
constant: false
is: http://identifiers.org/cas/541-15-1
initial amount: NaN

666996
type: Constraint
message: Error: Species concentration UroporphyrinogenI_s is out of the hard bounds.

768751
type: Reaction
product: 768775
reactant: 768763
notes: Vesicular transport
fast: false
reversible: true
name: r1365

768775
type: SpeciesReference
stoichiometry: 1.0
species: 636799

636799
type: Species
initial amount: NaN
initial concentration: 2.6E-4
constant: false
name: Linolenate_c
is: C06427
in compartment: 623911
has only substance units: false
is: CHEBI:27432
is: http://identifiers.org/cas/463-40-1
is: http://identifiers.org/pubchem.compound/8662
boundary condition: false

768763
type: SpeciesReference
stoichiometry: 1.0
species: 636823

636823
type: Species
is: C06427
initial amount: NaN
boundary condition: false
initial concentration: 2.6E-4
is: CHEBI:27432
is: http://identifiers.org/cas/463-40-1
is: http://identifiers.org/pubchem.compound/8662
in compartment: 623851
name: Linolenate_l
constant: false
has only substance units: false

652286
type: Constraint
message: Error: Species concentration Adenylyl_sulfate_c is out of the hard bounds.

647594
type: Constraint
message: Warning: Species concentration Malonyl-CoA_c is out of the soft bounds.

626215
type: Species
is: http://identifiers.org/cas/65-47-4
initial amount: NaN
is: C00063
is: http://identifiers.org/pubchem.compound/3363
is: CHEBI:17677
name: CTP_s
initial concentration: 2.6E-4
has only substance units: false
boundary condition: true
in compartment: 623935
constant: false

638034
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1-Acylglycerol-3P-VLDL-PE-pool_c

675132
type: Constraint
message: Error: Species concentration Hexadecenal_c is out of the hard bounds.

624439
type: Species
has only substance units: false
constant: false
initial concentration: 2.0E-5
in compartment: 623923
name: NADH_r
is: http://identifiers.org/pubchem.compound/3306
is: CHEBI:16908
is: C00004
initial amount: NaN
boundary condition: false

677555
type: Constraint
message: Error: Species concentration CMP-activated-N-acetylneuraminate_n is out of the hard bounds.

628111
type: Species
initial concentration: 2.6E-4
is: CHEBI:17203
in compartment: 623863
is: http://identifiers.org/cas/147-85-3
name: Proline_m
has only substance units: false
is: C00148
is: http://identifiers.org/pubchem.compound/3448
initial amount: NaN
boundary condition: false
constant: false

664501
type: Constraint
message: Error: Species concentration 3-Oxotetradecanoyl-CoA_m is out of the hard bounds.

746651
type: Reaction
product: 746675
reactant: 746663
notes: Facilitated diffusion
fast: false
reversible: true
name: r1117

746675
type: SpeciesReference
stoichiometry: 1.0
species: 630535

630535
type: Species
boundary condition: false
is: http://identifiers.org/cas/365-07-1
initial amount: NaN
name: dTMP_m
constant: false
initial concentration: 2.6E-4
is: C00364
in compartment: 623863
is: CHEBI:17013
has only substance units: false
is: http://identifiers.org/pubchem.compound/3655

746663
type: SpeciesReference
stoichiometry: 1.0
species: 630511

630511
type: Species
in compartment: 623911
is: http://identifiers.org/pubchem.compound/3655
initial amount: NaN
name: dTMP_c
is: http://identifiers.org/cas/365-07-1
constant: false
is: C00364
initial concentration: 2.6E-4
has only substance units: false
is: CHEBI:17013
boundary condition: false

639534
type: Species
in compartment: 623935
initial concentration: 2.6E-4
is: CHEBI:34306
has only substance units: false
is: http://identifiers.org/pubchem.compound/17395746
boundary condition: false
is: http://identifiers.org/cas/79551-86-3
constant: false
initial amount: NaN
is: C14748
name: 20-hydroxy-arachidonate_s

638802
type: Species
is: http://identifiers.org/cas/1783-84-2
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/7850023
in compartment: 623911
boundary condition: false
initial amount: NaN
is: C03242
has only substance units: false
name: Dihomo-gamma-linolenate_c
constant: false

653078
type: Constraint
message: Error: Species concentration Glycerate_c is out of the hard bounds.

775147
type: Reaction
product: 775183
name: r1473
is: K00255
reactant: 775171
reactant: 775159
reversible: true
fast: false
notes: long-chain-acyl-CoA dehydrogenase EC:1.3.99.13
is: ENSMUSG00000026003
product: 775195

775183
type: SpeciesReference
stoichiometry: 1.0
species: 633163

633163
type: Species
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/4556
has only substance units: false
boundary condition: false
is: C01352
constant: false
name: FADH2_m
initial amount: NaN
in compartment: 623863
is: CHEBI:17877

775171
type: SpeciesReference
stoichiometry: 1.0
species: 640614

640614
type: Species
is: http://identifiers.org/pubchem.compound/25244394
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: palmitoleoyl-CoA_m

775159
type: SpeciesReference
stoichiometry: 1.0
species: 625075

625075
type: Species
initial concentration: 2.6E-4
boundary condition: false
is: http://identifiers.org/cas/146-14-5
is: CHEBI:16238
name: FAD_m
has only substance units: false
is: http://identifiers.org/pubchem.compound/3318
in compartment: 623863
is: C00016
initial amount: NaN
constant: false

775195
type: SpeciesReference
stoichiometry: 1.0
species: 640842

640842
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: trans,cis-hexadeca-2,9-dienoyl-CoA_m

846527
type: Reaction
product: 846551
reactant: 846539
notes: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is: ENSMUSG00000027359
fast: false
reversible: false
name: r2444

846551
type: SpeciesReference
stoichiometry: 1.0
species: 639474

639474
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5649
has only substance units: false
constant: false
is: C02679
name: lauric-acid_c
is: CHEBI:30805
is: http://identifiers.org/cas/143-07-7
initial concentration: 2.6E-4
boundary condition: false
in compartment: 623911

846539
type: SpeciesReference
stoichiometry: 1.0
species: 639486

639486
type: Species
is: C02679
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5649
is: http://identifiers.org/cas/143-07-7
initial concentration: 2.6E-4
boundary condition: false
has only substance units: false
name: lauric-acid_s
constant: false
in compartment: 623935
is: CHEBI:30805

793553
type: Reaction
reactant: 793577
reactant: 793565
product: 793625
name: r1739
fast: false
is: ENSMUSG00000031904
reactant: 793589
product: 793613
notes: Y+LAT2 Utilized transport
reversible: false
product: 793601

793577
type: SpeciesReference
stoichiometry: 1.0
species: 627007

793565
type: SpeciesReference
stoichiometry: 1.0
species: 626419

626419
type: Species
in compartment: 623935
is: CHEBI:16643
is: http://identifiers.org/cas/63-68-3
has only substance units: false
name: Methionine_s
is: C00073
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3373
constant: false
initial amount: NaN
boundary condition: true

793625
type: SpeciesReference
stoichiometry: 1.0
species: 633079

793589
type: SpeciesReference
stoichiometry: 1.0
species: 633091

793613
type: SpeciesReference
stoichiometry: 1.0
species: 627019

793601
type: SpeciesReference
stoichiometry: 1.0
species: 626407

665581
type: Constraint
message: Error: Species concentration 5beta-Cholestane-3alpha,7alpha,12alpha,26-tetrol_m is out of the hard bounds.

652034
type: Constraint
message: Warning: Species concentration Sarcosine_c is out of the soft bounds.

649658
type: Constraint
message: Warning: Species concentration Methanol_s is out of the soft bounds.

644453
type: Constraint
message: Warning: Species concentration Pyruvate_s is out of the soft bounds.

716140
type: Reaction
reactant: 716152
fast: false
product: 716188
is: R03316
is: ENSMUSG00000020456
product: 716176
notes: 2-oxoglutarate dehydrogenase E1 component Citrate cycle (TCA cycle) EC:1.2.4.2
reversible: true
name: r0620
is: K00164
reactant: 716164

716152
type: SpeciesReference
stoichiometry: 1.0
species: 635611

635611
type: Species
constant: false
is: CHEBI:1463
has only substance units: false
initial concentration: 2.6E-4
boundary condition: false
initial amount: NaN
name: 3-Carboxy-1-hydroxypropyl-ThPP_m
is: http://identifiers.org/pubchem.compound/7755
in compartment: 623863
is: C05381

716188
type: SpeciesReference
stoichiometry: 1.0
species: 626371

626371
type: Species
is: http://identifiers.org/pubchem.compound/3368
name: Thiamin-PP_m
boundary condition: false
initial concentration: 2.6E-4
initial amount: NaN
is: C00068
constant: false
in compartment: 623863
is: CHEBI:9532
has only substance units: false

716176
type: SpeciesReference
stoichiometry: 1.0
species: 632875

632875
type: Species
initial concentration: 2.6E-4
in compartment: 623863
is: C01169
is: CHEBI:17432
name: S-Succinyldihydrolipoamide_m
constant: false
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/4396
initial amount: NaN

716164
type: SpeciesReference
stoichiometry: 1.0
species: 629347

629347
type: Species
boundary condition: false
in compartment: 623863
initial amount: NaN
has only substance units: false
name: Lipoamide_m
is: http://identifiers.org/pubchem.compound/863
is: http://identifiers.org/cas/940-69-2
constant: false
is: C00248
initial concentration: 2.6E-4

668592
type: Constraint
message: Warning: Species concentration Cholesterol-ester-pool_l is out of the soft bounds.

704958
type: Reaction
is: K08766
notes: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: ENSMUSG00000028607
is: ENSMUSG00000024900
product: 705006
is: K08765
reversible: true
name: r0439
reactant: 704970
is: R01923
reactant: 704982
product: 704994
fast: false

705006
type: SpeciesReference
stoichiometry: 1.0
species: 640686

640686
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: linoleic-Carnitine_c

704970
type: SpeciesReference
stoichiometry: 1.0
species: 637351

637351
type: Species
is: CHEBI:15530
in compartment: 623911
constant: false
is: http://identifiers.org/pubchem.compound/5139
initial concentration: 2.6E-4
initial amount: NaN
has only substance units: false
name: Linoleoyl-CoA_c
is: C02050
boundary condition: false

704982
type: SpeciesReference
stoichiometry: 1.0
species: 629983

704994
type: SpeciesReference
stoichiometry: 1.0
species: 624799

643578
type: Constraint
message: Error: Species concentration Pi_p is out of the hard bounds.

650318
type: Constraint
message: Error: Species concentration Malate_c is out of the hard bounds.

635839
type: Species
name: 3alpha,7alpha,12alpha-Trihydroxycoprostane_m
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/7816
initial amount: NaN
constant: false
boundary condition: false
in compartment: 623863
is: http://identifiers.org/cas/547-96-6
is: CHEBI:16496
is: C05454
has only substance units: false

653114
type: Constraint
message: Warning: Species concentration Glycerate_m is out of the soft bounds.

674784
type: Constraint
message: Warning: Species concentration prostaglandin-f2beta_c is out of the soft bounds.

655202
type: Constraint
message: Warning: Species concentration dUMP_m is out of the soft bounds.

689741
type: Reaction
notes: L-Glutamine:D-fructose-6-phosphate aminotransferase (hexose isomerizing) Glutamate metabolism / Aminosugars metabolism EC:2.6.1.16
name: r0190
is: ENSMUSG00000029992
is: R00768
product: 689789
reactant: 689765
is: K00820
is: ENSMUSG00000020363
reactant: 689753
product: 689777
reversible: false
fast: false

689789
type: SpeciesReference
stoichiometry: 1.0
species: 630343

689765
type: SpeciesReference
stoichiometry: 1.0
species: 626815

689753
type: SpeciesReference
stoichiometry: 1.0
species: 626251

689777
type: SpeciesReference
stoichiometry: 1.0
species: 625291

684269
type: Reaction
is: ENSMUSG00000020321
is: K00026
is: K00024
product: 684305
reactant: 684293
product: 684317
reactant: 684281
is: R00342
fast: false
reversible: true
notes: (S)-malate:NAD+ oxidoreductase Citrate cycle (TCA cycle) EC:1.1.1.37
name: r0104
is: K00025

684305
type: SpeciesReference
stoichiometry: 1.0
species: 625603

625603
type: Species
name: OAA_c
is: C00036
is: CHEBI:30744
constant: false
is: http://identifiers.org/pubchem.compound/3338
in compartment: 623911
is: http://identifiers.org/cas/328-42-7
has only substance units: false
boundary condition: false
initial concentration: 5.05E-5
initial amount: NaN

684293
type: SpeciesReference
stoichiometry: 1.0
species: 628123

684317
type: SpeciesReference
stoichiometry: 1.0
species: 624451

684281
type: SpeciesReference
stoichiometry: 1.0
species: 624403

869058
type: Reaction
product: 869226
product: 869214
product: 869154
fast: false
product: 869118
product: 869286
product: 869238
product: 869178
product: 869166
reactant: 869094
product: 869310
product: 869298
product: 869322
reversible: false
product: 869250
product: 869190
notes: Protein degradation
product: 869130
product: 869334
product: 869358
reactant: 869070
product: 869262
product: 869142
reactant: 869082
product: 869346
product: 869106
name: r2591
product: 869202
product: 869274

869226
type: SpeciesReference
stoichiometry: 9.0
species: 626407

869214
type: SpeciesReference
stoichiometry: 59.0
species: 627559

869154
type: SpeciesReference
stoichiometry: 14.0
species: 626575

869118
type: SpeciesReference
stoichiometry: 3.0
species: 627007

869286
type: SpeciesReference
stoichiometry: 22.0
species: 626299

869238
type: SpeciesReference
stoichiometry: 9.0
species: 628147

869178
type: SpeciesReference
stoichiometry: 8.0
species: 627835

869166
type: SpeciesReference
stoichiometry: 193.0
species: 625627

869094
type: SpeciesReference
stoichiometry: 351.5
species: 624259

869310
type: SpeciesReference
stoichiometry: 31.0
species: 628531

869298
type: SpeciesReference
stoichiometry: 22.0
species: 628699

869322
type: SpeciesReference
stoichiometry: 2.0
species: 626539

869250
type: SpeciesReference
stoichiometry: 145.0
species: 628075

869190
type: SpeciesReference
stoichiometry: 12.0
species: 630798

869130
type: SpeciesReference
stoichiometry: 18.0
species: 625867

869334
type: SpeciesReference
stoichiometry: 16.0
species: 626695

869358
type: SpeciesReference
stoichiometry: 351.5
species: 624727

869070
type: SpeciesReference
stoichiometry: 1.0
species: 641202

641202
type: Species
is: P25067
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CO8A2_c

869262
type: SpeciesReference
stoichiometry: 25.0
species: 626251

869142
type: SpeciesReference
stoichiometry: 24.0
species: 625291

869082
type: SpeciesReference
stoichiometry: 351.5
species: 624331

869346
type: SpeciesReference
stoichiometry: 351.5
species: 624655

869106
type: SpeciesReference
stoichiometry: 42.0
species: 625675

869202
type: SpeciesReference
stoichiometry: 28.0
species: 625819

869274
type: SpeciesReference
stoichiometry: 21.0
species: 626155

669048
type: Constraint
message: Warning: Species concentration PC-VLDL-pool_r is out of the soft bounds.

697048
type: Reaction
product: 697096
fast: false
is: ENSMUSG00000028910
reversible: true
reactant: 697072
is: R01278
notes: trans-Hexadec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: 697060
is: K07512
name: r0309
product: 697084

697096
type: SpeciesReference
stoichiometry: 1.0
species: 624511

624511
type: Species
is: C00005
is: CHEBI:16474
boundary condition: false
is: http://identifiers.org/pubchem.compound/3307
initial amount: NaN
is: http://identifiers.org/cas/2646-71-1
name: NADPH_m
constant: false
has only substance units: false
in compartment: 623863
initial concentration: 5.1E-5

697072
type: SpeciesReference
stoichiometry: 1.0
species: 624559

624559
type: Species
in compartment: 623863
boundary condition: false
is: CHEBI:18009
name: NADP+_m
has only substance units: false
is: http://identifiers.org/cas/53-59-8
is: C00006
constant: false
initial concentration: 1.0E-4
is: http://identifiers.org/pubchem.compound/3308
initial amount: NaN

697060
type: SpeciesReference
stoichiometry: 1.0
species: 628243

628243
type: Species
is: C00154
initial concentration: 2.6E-4
name: Palmitoyl-CoA_m
is: CHEBI:15525
is: http://identifiers.org/cas/1763-10-6
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
in compartment: 623863
is: http://identifiers.org/pubchem.compound/3454

697084
type: SpeciesReference
stoichiometry: 1.0
species: 635431

635431
type: Species
initial amount: NaN
boundary condition: false
in compartment: 623863
has only substance units: false
constant: false
name: (2E)-Hexadecenoyl-CoA_m
is: C05272
initial concentration: 1.0E-5
is: CHEBI:28935
is: http://identifiers.org/pubchem.compound/7659

806798
type: Reaction
reactant: 806810
notes: Y+LAT2 Utilized transport
name: r1896
product: 806858
reactant: 806822
product: 806870
reversible: false
fast: false
reactant: 806834
product: 806846
is: ENSMUSG00000031904

806810
type: SpeciesReference
stoichiometry: 1.0
species: 629563

806858
type: SpeciesReference
stoichiometry: 1.0
species: 630810

806822
type: SpeciesReference
stoichiometry: 1.0
species: 630798

806870
type: SpeciesReference
stoichiometry: 1.0
species: 633079

806834
type: SpeciesReference
stoichiometry: 1.0
species: 633091

806846
type: SpeciesReference
stoichiometry: 1.0
species: 629551

676487
type: Constraint
message: Warning: Species concentration Collagen_CO8A2_c is out of the soft bounds.

769952
type: Reaction
is: ENSMUSG00000030244
product: 769988
reactant: 769976
notes: EC:2.4.1.11
product: 770000
reactant: 769964
is: ENSMUSG00000003865
name: r1388
reversible: false
fast: false

769988
type: SpeciesReference
stoichiometry: 1.0
species: 639174

639174
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Glycogenin-G11_c

769976
type: SpeciesReference
stoichiometry: 1.0
species: 639162

639162
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Glycogenin-G8_c

770000
type: SpeciesReference
stoichiometry: 3.0
species: 625027

625027
type: Species
is: http://identifiers.org/pubchem.compound/3317
constant: false
initial concentration: 2.6E-4
has only substance units: false
name: UDP_c
is: CHEBI:17659
in compartment: 623911
initial amount: NaN
boundary condition: false
is: C00015
is: http://identifiers.org/cas/58-98-0

769964
type: SpeciesReference
stoichiometry: 3.0
species: 625447

625447
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/3331
is: CHEBI:18066
in compartment: 623911
initial concentration: 0.00255
is: http://identifiers.org/cas/133-89-1
initial amount: NaN
has only substance units: false
boundary condition: true
is: C00029
name: UDP-glucose_c

643974
type: Constraint
message: Warning: Species concentration PPi_p is out of the soft bounds.

667920
type: Constraint
message: Warning: Species concentration 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol_r is out of the soft bounds.

662089
type: Constraint
message: Warning: Species concentration (3Z)-Dodecenoyl-CoA_m is out of the soft bounds.

712373
type: Reaction
reversible: true
product: 712421
product: 712409
is: R02570
notes: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is: K00658
reactant: 712397
is: ENSMUSG00000004789
name: r0556
fast: false
reactant: 712385

712421
type: SpeciesReference
stoichiometry: 1.0
species: 632875

712409
type: SpeciesReference
stoichiometry: 1.0
species: 624811

712397
type: SpeciesReference
stoichiometry: 1.0
species: 626875

712385
type: SpeciesReference
stoichiometry: 1.0
species: 631662

631662
type: Species
name: Dihydrolipoamide_m
in compartment: 623863
is: C00579
is: http://identifiers.org/pubchem.compound/3858
initial concentration: 2.6E-4
constant: false
is: http://identifiers.org/cas/3884-47-7
has only substance units: false
is: CHEBI:17694
initial amount: NaN
boundary condition: false

720124
type: Reaction
notes: L-1-Pyrroline-3-hydroxy-5-carboxylate:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
fast: false
is: R04444
name: r0685
product: 720172
reactant: 720136
reactant: 720160
reversible: true
is: K13821
reactant: 720148
is: ENSMUSG00000028737
product: 720184
is: K00294

720172
type: SpeciesReference
stoichiometry: 1.0
species: 624463

720136
type: SpeciesReference
stoichiometry: 1.0
species: 634639

634639
type: Species
has only substance units: false
boundary condition: false
in compartment: 623863
is: C04281
name: L-1-Pyrroline-3-hydroxy-5-carboxylate_m
is: http://identifiers.org/pubchem.compound/6943
initial amount: NaN
constant: false
initial concentration: 2.6E-4
is: CHEBI:6151

720160
type: SpeciesReference
stoichiometry: 2.0
species: 624295

624295
type: Species
is: C00001
is: http://identifiers.org/pubchem.compound/3303
name: H2O_m
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/cas/7732-18-5
in compartment: 623863
is: CHEBI:15377
initial amount: NaN
constant: false
boundary condition: false

720148
type: SpeciesReference
stoichiometry: 1.0
species: 624415

720184
type: SpeciesReference
stoichiometry: 1.0
species: 636583

636583
type: Species
constant: false
is: C05947
initial amount: NaN
boundary condition: false
has only substance units: false
name: L-erythro-4-Hydroxyglutamate_m
in compartment: 623863
is: CHEBI:21285
is: http://identifiers.org/pubchem.compound/8231
initial concentration: 2.6E-4

663781
type: Constraint
message: Error: Species concentration 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA_p is out of the hard bounds.

677999
type: Reaction
product: 678059
product: 678083
name: r0003
fast: false
product: 678071
reversible: true
product: 678047
notes: Particle dis-/assembly
product: 678035
reactant: 678011
product: 678023

678059
type: SpeciesReference
stoichiometry: 20.0
species: 628639

628639
type: Species
in compartment: 623923
is: http://identifiers.org/pubchem.compound/3487
name: Cholesterol_r
is: http://identifiers.org/cas/57-88-5
initial amount: NaN
is: CHEBI:16113
initial concentration: 1.0E-8
boundary condition: true
has only substance units: false
constant: false
is: C00187

678083
type: SpeciesReference
stoichiometry: 75.0
species: 637627

637627
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: SM-pool_r

678071
type: SpeciesReference
stoichiometry: 25.0
species: 637531

637531
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: PE-VLDL-pool_r

678047
type: SpeciesReference
stoichiometry: 30.0
species: 637579

637579
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: PS-VLDL-pool_r

678035
type: SpeciesReference
stoichiometry: 90.0
species: 637483

637483
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: PC-VLDL-pool_r

678011
type: SpeciesReference
stoichiometry: 1.0
species: 637063

637063
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-14
initial amount: NaN
in compartment: 623923
name: HDL_r

678023
type: SpeciesReference
stoichiometry: 2.0
species: 624055

624055
type: Species
is: P02647
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623923
name: ApoA1_r

659725
type: Constraint
message: Error: Species concentration trans-4-Hydroxy-L-proline_c is out of the hard bounds.

860299
type: Reaction
reactant: 860455
reactant: 860371
reactant: 860323
is: ENSMUSG00000067158
reactant: 860359
product: 860575
reactant: 860491
reactant: 860431
reactant: 860407
name: r2564
reversible: false
reactant: 860515
product: 860611
reactant: 860551
reactant: 860539
reactant: 860467
reactant: 860383
reactant: 860335
fast: false
reactant: 860419
reactant: 860395
reactant: 860527
product: 860587
reactant: 860443
reactant: 860311
reactant: 860563
reactant: 860503
notes: Collagen alpha-4(IV) chain Protein assembly
product: 860623
product: 860599
reactant: 860479
reactant: 860347

860455
type: SpeciesReference
stoichiometry: 345.0
species: 628075

860371
type: SpeciesReference
stoichiometry: 464.0
species: 625627

860323
type: SpeciesReference
stoichiometry: 32.0
species: 627007

860359
type: SpeciesReference
stoichiometry: 45.0
species: 626575

860575
type: SpeciesReference
stoichiometry: 1.0
species: 641046

641046
type: Species
is: P53420
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CO4A4_c

860491
type: SpeciesReference
stoichiometry: 76.0
species: 626299

860431
type: SpeciesReference
stoichiometry: 24.0
species: 626407

860407
type: SpeciesReference
stoichiometry: 83.0
species: 625819

860515
type: SpeciesReference
stoichiometry: 50.0
species: 628531

860611
type: SpeciesReference
stoichiometry: 1690.0
species: 625135

625135
type: Species
is: http://identifiers.org/cas/61-19-8
boundary condition: false
is: http://identifiers.org/pubchem.compound/3322
has only substance units: false
name: AMP_c
initial concentration: 4.2E-4
constant: false
in compartment: 623911
is: C00020
initial amount: NaN
is: CHEBI:16027

860551
type: SpeciesReference
stoichiometry: 6760.0
species: 624331

860539
type: SpeciesReference
stoichiometry: 23.0
species: 626695

860467
type: SpeciesReference
stoichiometry: 48.0
species: 626251

860383
type: SpeciesReference
stoichiometry: 33.0
species: 627835

860335
type: SpeciesReference
stoichiometry: 72.0
species: 625867

860419
type: SpeciesReference
stoichiometry: 101.0
species: 627559

860395
type: SpeciesReference
stoichiometry: 43.0
species: 630798

860527
type: SpeciesReference
stoichiometry: 9.0
species: 626539

860587
type: SpeciesReference
stoichiometry: 5070.0
species: 624655

860443
type: SpeciesReference
stoichiometry: 15.0
species: 628147

860311
type: SpeciesReference
stoichiometry: 69.0
species: 625675

860563
type: SpeciesReference
stoichiometry: 6760.0
species: 624259

860503
type: SpeciesReference
stoichiometry: 30.0
species: 628699

860623
type: SpeciesReference
stoichiometry: 1690.0
species: 624919

624919
type: Species
constant: false
is: C00013
is: CHEBI:18361
boundary condition: true
initial amount: NaN
initial concentration: 1.0E-8
name: PPi_c
in compartment: 623911
is: http://identifiers.org/cas/2466-09-3
is: http://identifiers.org/pubchem.compound/3315
has only substance units: false

860599
type: SpeciesReference
stoichiometry: 5070.0
species: 624727

860479
type: SpeciesReference
stoichiometry: 70.0
species: 626155

860347
type: SpeciesReference
stoichiometry: 58.0
species: 625291

669360
type: Constraint
message: Warning: Species concentration SM-pool_b is out of the soft bounds.

670668
type: Constraint
message: Error: Species concentration Acyl-CoA-VLDL-TG3-pool_c is out of the hard bounds.

760030
type: Reaction
product: 760066
product: 760054
reactant: 760042
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r1329

760066
type: SpeciesReference
stoichiometry: 1.0
species: 639018

639018
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623911
name: FADH-redox-potential_c

760054
type: SpeciesReference
stoichiometry: 1.0
species: 625051

625051
type: Species
initial concentration: 2.6E-4
constant: false
initial amount: NaN
in compartment: 623911
name: FAD_c
is: C00016
is: http://identifiers.org/cas/146-14-5
has only substance units: false
is: CHEBI:16238
boundary condition: true
is: http://identifiers.org/pubchem.compound/3318

760042
type: SpeciesReference
stoichiometry: 1.0
species: 633151

633151
type: Species
name: FADH2_c
initial amount: NaN
is: C01352
is: http://identifiers.org/pubchem.compound/4556
boundary condition: false
in compartment: 623911
constant: false
initial concentration: 2.6E-4
has only substance units: false
is: CHEBI:17877

649538
type: Constraint
message: Warning: Species concentration IMP_c is out of the soft bounds.

676883
type: Constraint
message: Error: Species concentration Collagen_COLQ_c is out of the hard bounds.

660613
type: Constraint
message: Error: Species concentration Linoleate_s is out of the hard bounds.

651890
type: Constraint
message: Warning: Species concentration Maltose_s is out of the soft bounds.

828311
type: Reaction
name: r2195
is: ENSMUSG00000030237
product: 828359
fast: false
product: 828371
is: ENSMUSG00000079262
is: ENSMUSG00000041698
reactant: 828335
reactant: 828347
product: 828383
reversible: true
is: ENSMUSG00000063975
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: 828323

828359
type: SpeciesReference
stoichiometry: 1.0
species: 633715

633715
type: Species
is: http://identifiers.org/pubchem.compound/5481
in compartment: 623911
initial amount: NaN
boundary condition: false
is: http://identifiers.org/cas/6893-02-3
constant: false
name: Triiodothyronine_c
is: C02465
initial concentration: 2.6E-4
is: CHEBI:18258
has only substance units: false

828371
type: SpeciesReference
stoichiometry: 1.0
species: 629731

828335
type: SpeciesReference
stoichiometry: 1.0
species: 629719

828347
type: SpeciesReference
stoichiometry: 1.0
species: 625915

828383
type: SpeciesReference
stoichiometry: 1.0
species: 625927

828323
type: SpeciesReference
stoichiometry: 1.0
species: 633727

633727
type: Species
has only substance units: false
name: Triiodothyronine_s
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/5481
in compartment: 623935
initial amount: NaN
is: C02465
is: http://identifiers.org/cas/6893-02-3
initial concentration: 2.6E-4
is: CHEBI:18258

636163
type: Species
in compartment: 623911
initial concentration: 2.6E-4
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate_c
constant: false
is: http://identifiers.org/pubchem.compound/7956
initial amount: NaN
boundary condition: false
is: C05645
has only substance units: false

684641
type: Reaction
product: 684677
is: K00811
fast: false
reactant: 684653
is: K00812
name: r0109
is: R00355
is: K14454
is: K00813
is: K11358
reactant: 684665
product: 684689
is: K14455
reversible: true
is: ENSMUSG00000025190
notes: L-Aspartate:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.1

684677
type: SpeciesReference
stoichiometry: 1.0
species: 625603

684653
type: SpeciesReference
stoichiometry: 1.0
species: 625339

684665
type: SpeciesReference
stoichiometry: 1.0
species: 625867

684689
type: SpeciesReference
stoichiometry: 1.0
species: 625291

687918
type: Reaction
is: ENSMUSG00000029597
fast: false
notes: L-Serine hydro-lyase (deaminating) Cysteine metabolism EC:4.3.1.17
reversible: false
product: 687954
product: 687942
is: R00590
name: r0161
is: K01752
reactant: 687930

687954
type: SpeciesReference
stoichiometry: 1.0
species: 633679

633679
type: Species
has only substance units: false
boundary condition: false
in compartment: 623911
is: C02218
is: CHEBI:17123
is: http://identifiers.org/pubchem.compound/5284
constant: false
name: Dehydroalanine_c
initial amount: NaN
initial concentration: 2.6E-4

687942
type: SpeciesReference
stoichiometry: 1.0
species: 624259

687930
type: SpeciesReference
stoichiometry: 1.0
species: 626299

662485
type: Constraint
message: Error: Species concentration 4-Nitrophenyl-P_s is out of the hard bounds.

676739
type: Constraint
message: Error: Species concentration Collagen_COGA1_c is out of the hard bounds.

627115
type: Species
boundary condition: false
is: CHEBI:15539
is: http://identifiers.org/cas/317-66-8
name: Propanoyl-CoA_p
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3400
initial amount: NaN
in compartment: 623899
is: C00100
has only substance units: false
constant: false

740058
type: Reaction
product: 740082
reactant: 740070
notes: Postulated transport reaction
fast: false
reversible: false
name: r1076

740082
type: SpeciesReference
stoichiometry: 1.0
species: 626299

740070
type: SpeciesReference
stoichiometry: 1.0
species: 626323

626323
type: Species
is: http://identifiers.org/cas/56-45-1
initial concentration: 2.6E-4
in compartment: 623851
initial amount: NaN
name: Serine_l
is: http://identifiers.org/pubchem.compound/3365
has only substance units: false
is: C00065
is: CHEBI:17115
boundary condition: false
constant: false

646289
type: Constraint
message: Error: Species concentration Sulfate_m is out of the hard bounds.

639402
type: Species
is: C01353
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
constant: false
initial amount: NaN
in compartment: 623911
name: Carbonate_c
is: CHEBI:28976
is: http://identifiers.org/cas/463-79-6
is: http://identifiers.org/pubchem.compound/4557

851842
type: Reaction
product: 851866
reactant: 851854
notes: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: ENSMUSG00000027075
fast: false
reversible: true
name: r2525

851866
type: SpeciesReference
stoichiometry: 1.0
species: 626251

851854
type: SpeciesReference
stoichiometry: 1.0
species: 626263

624163
type: Species
is: P02655
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623923
name: ApoC2_r

649934
type: Constraint
message: Error: Species concentration Inositol_s is out of the hard bounds.

667632
type: Constraint
message: Warning: Species concentration gamma-Linolenate_l is out of the soft bounds.

662233
type: Constraint
message: Warning: Species concentration 3-Methylcrotonyl-CoA_m is out of the soft bounds.

703263
type: Reaction
reactant: 703288
fast: false
notes: ATP:nucleoside-diphosphate phosphatransferase Purine metabolism EC:2.7.4.6
is: ENSMUSG00000026575
is: ENSMUSG00000035984
is: ENSMUSG00000037601
product: 703300
is: R01857
reversible: true
is: ENSMUSG00000024177
is: ENSMUSG00000073435
is: ENSMUSG00000020857
name: r0411
product: 703312
reactant: 703276
is: ENSMUSG00000032478
is: K00940

703288
type: SpeciesReference
stoichiometry: 1.0
species: 630427

703300
type: SpeciesReference
stoichiometry: 1.0
species: 624655

703312
type: SpeciesReference
stoichiometry: 1.0
species: 629671

629671
type: Species
boundary condition: true
name: dGTP_c
initial amount: NaN
in compartment: 623911
is: http://identifiers.org/cas/2564-35-4
is: C00286
is: CHEBI:16497
initial concentration: 2.6E-4
has only substance units: false
is: http://identifiers.org/pubchem.compound/3581
constant: false

703276
type: SpeciesReference
stoichiometry: 1.0
species: 624331

834253
type: Reaction
reactant: 834277
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: 834265
fast: false
product: 834325
product: 834301
name: r2265
product: 834313
reactant: 834289
is: ENSMUSG00000030236
reversible: true

834277
type: SpeciesReference
stoichiometry: 1.0
species: 629719

834265
type: SpeciesReference
stoichiometry: 1.0
species: 640074

640074
type: Species
in compartment: 623935
constant: false
is: CHEBI:27624
boundary condition: false
initial concentration: 2.6E-4
is: C00959
name: prostaglandin-b1_s
is: http://identifiers.org/pubchem.compound/4210
initial amount: NaN
has only substance units: false
is: http://identifiers.org/cas/13345-51-2

834325
type: SpeciesReference
stoichiometry: 1.0
species: 640002

834301
type: SpeciesReference
stoichiometry: 1.0
species: 640062

834313
type: SpeciesReference
stoichiometry: 1.0
species: 629731

834289
type: SpeciesReference
stoichiometry: 1.0
species: 639990

637807
type: Species
is: http://identifiers.org/pubchem.compound/24702202
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: Cholesterol-ester-palmn_r

630978
type: Species
is: CHEBI:15859
is: C00438
in compartment: 623911
name: N-Carbamoyl-L-aspartate_c
has only substance units: false
is: http://identifiers.org/pubchem.compound/3727
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 2.6E-4

787686
type: Reaction
reversible: true
is: ENSMUSG00000031904
product: 787734
reactant: 787698
reactant: 787710
notes: Y+LAT2 Utilized transport
name: r1668
product: 787722
fast: false

787734
type: SpeciesReference
stoichiometry: 1.0
species: 627847

627847
type: Species
has only substance units: false
constant: false
is: CHEBI:15971
boundary condition: true
is: http://identifiers.org/pubchem.compound/3435
in compartment: 623935
initial amount: NaN
name: Histidine_s
is: C00135
is: http://identifiers.org/cas/71-00-1
initial concentration: 2.6E-4

787698
type: SpeciesReference
stoichiometry: 1.0
species: 626167

787710
type: SpeciesReference
stoichiometry: 1.0
species: 627835

787722
type: SpeciesReference
stoichiometry: 1.0
species: 626155

781542
type: Reaction
product: 781590
product: 781578
name: r1566
reactant: 781566
reversible: true
is: ENSMUSG00000040010
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: 781554
fast: false

781590
type: SpeciesReference
stoichiometry: 1.0
species: 628087

781578
type: SpeciesReference
stoichiometry: 1.0
species: 625675

781566
type: SpeciesReference
stoichiometry: 1.0
species: 628075

781554
type: SpeciesReference
stoichiometry: 1.0
species: 625687

625687
type: Species
name: Alanine_s
is: http://identifiers.org/cas/56-41-7
is: CHEBI:16977
constant: false
boundary condition: true
initial concentration: 2.6E-4
in compartment: 623935
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3343
has only substance units: false
is: C00041

637771
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623851
name: 2-Lysolecithin-pool_l

674652
type: Constraint
message: Error: Species concentration prostaglandin-e3_s is out of the hard bounds.

723248
type: Reaction
is: R00756
reactant: 723272
fast: false
product: 723284
product: 723296
reactant: 723260
notes: ATP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
name: r0736
is: ENSMUSG00000020277
reversible: false

723272
type: SpeciesReference
stoichiometry: 1.0
species: 626815

723284
type: SpeciesReference
stoichiometry: 1.0
species: 624655

723296
type: SpeciesReference
stoichiometry: 1.0
species: 630355

630355
type: Species
name: Fructose-1,6PP_c
initial amount: NaN
is: C00354
constant: false
in compartment: 623911
initial concentration: 0.0021
is: http://identifiers.org/pubchem.compound/3647
is: http://identifiers.org/cas/488-69-7
has only substance units: false
boundary condition: false
is: CHEBI:16905

723260
type: SpeciesReference
stoichiometry: 1.0
species: 624331

843984
type: Reaction
reactant: 844020
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
name: r2404
reactant: 843996
reversible: true
product: 844043
product: 844055
product: 844031
is: ENSMUSG00000050304
reactant: 844007
fast: false

844020
type: SpeciesReference
stoichiometry: 1.0
species: 626647

843996
type: SpeciesReference
stoichiometry: 1.0
species: 626503

626503
type: Species
is: http://identifiers.org/pubchem.compound/3377
is: CHEBI:15729
name: Ornithine_c
boundary condition: false
initial concentration: 2.6E-4
constant: false
is: http://identifiers.org/cas/70-26-8
is: C00077
in compartment: 623911
initial amount: NaN
has only substance units: false

844043
type: SpeciesReference
stoichiometry: 1.0
species: 626155

844055
type: SpeciesReference
stoichiometry: 1.0
species: 626623

844031
type: SpeciesReference
stoichiometry: 1.0
species: 626527

626527
type: Species
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3377
initial amount: NaN
is: http://identifiers.org/cas/70-26-8
initial concentration: 2.6E-4
in compartment: 623863
boundary condition: false
is: C00077
is: CHEBI:15729
name: Ornithine_m

844007
type: SpeciesReference
stoichiometry: 1.0
species: 626191

711341
type: Reaction
is: R02484
product: 711377
is: ENSMUSG00000068417
is: ENSMUSG00000021871
is: K00758
reversible: true
reactant: 711365
reactant: 711353
notes: deoxyuridine:orthophosphate 2-deoxy-D-ribosyltransferase; deoxyuridine:orthophosphate ribosyltransferase Pyrimidine metabolism EC:2.4.2.23
is: K03784
is: K03783
is: ENSMUSG00000022615
product: 711389
fast: false
name: r0540

711377
type: SpeciesReference
stoichiometry: 1.0
species: 627235

627235
type: Species
has only substance units: false
is: CHEBI:17568
name: Uracil_c
is: C00106
boundary condition: false
is: http://identifiers.org/pubchem.compound/3406
initial amount: NaN
initial concentration: 2.6E-4
is: http://identifiers.org/cas/66-22-8
in compartment: 623911
constant: false

711365
type: SpeciesReference
stoichiometry: 1.0
species: 631386

631386
type: Species
constant: false
name: Deoxyuridine_c
has only substance units: false
initial amount: NaN
initial concentration: 2.6E-4
in compartment: 623911
is: CHEBI:16450
is: http://identifiers.org/pubchem.compound/3809
is: http://identifiers.org/cas/951-78-0
boundary condition: false
is: C00526

711353
type: SpeciesReference
stoichiometry: 1.0
species: 624727

711389
type: SpeciesReference
stoichiometry: 1.0
species: 631926

631926
type: Species
constant: false
is: C00672
initial concentration: 2.6E-4
name: 2-Deoxy-D-ribose-1P_c
is: CHEBI:28542
is: http://identifiers.org/pubchem.compound/3941
in compartment: 623911
has only substance units: false
boundary condition: false
initial amount: NaN

655814
type: Constraint
message: Error: Species concentration Dihydrofolate_c is out of the hard bounds.

820020
type: Reaction
reactant: 820032
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: 820068
is: ENSMUSG00000032902
name: r2078
reversible: true
product: 820056
reactant: 820044
fast: false

820032
type: SpeciesReference
stoichiometry: 1.0
species: 626635

626635
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-7
initial amount: NaN
in compartment: 623935
name: H+(PG)_s

820068
type: SpeciesReference
stoichiometry: 1.0
species: 628591

628591
type: Species
in compartment: 623911
initial amount: NaN
constant: false
is: http://identifiers.org/cas/79-33-4
boundary condition: false
is: http://identifiers.org/pubchem.compound/3486
name: L-Lactate_c
is: C00186
initial concentration: 2.6E-4
is: CHEBI:422
has only substance units: false

820056
type: SpeciesReference
stoichiometry: 1.0
species: 626623

820044
type: SpeciesReference
stoichiometry: 1.0
species: 628603

628603
type: Species
initial concentration: 2.6E-4
is: C00186
constant: false
boundary condition: true
has only substance units: false
in compartment: 623935
is: http://identifiers.org/pubchem.compound/3486
is: http://identifiers.org/cas/79-33-4
is: CHEBI:422
initial amount: NaN
name: L-Lactate_s

648194
type: Constraint
message: Warning: Species concentration beta-Alanine_c is out of the soft bounds.

643422
type: Constraint
message: Warning: Species concentration ADP_m is out of the soft bounds.

645677
type: Constraint
message: Warning: Species concentration Lysine_c is out of the soft bounds.

656174
type: Constraint
message: Error: Species concentration Farnesyl-PP_r is out of the hard bounds.

753299
type: Reaction
is: K14452
is: K14076
is: K14075
fast: false
product: 753347
reactant: 753311
notes: 1,2-Diacyl-sn-glycerol acylhydrolase Glycerolipid metabolism EC:3.1.1.3
is: ENSMUSG00000032207
is: K12298
reactant: 753323
is: K14074
is: K14073
is: K01046
name: r1226
product: 753335
reversible: false
is: K13534
is: R02687

753347
type: SpeciesReference
stoichiometry: 1.0
species: 638394

638394
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Fatty-acid-VLDL-PC-pool_c

753311
type: SpeciesReference
stoichiometry: 1.0
species: 624259

753323
type: SpeciesReference
stoichiometry: 1.0
species: 638238

638238
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1,2-Diacylglycerol-VLDL-PC-pool_c

753335
type: SpeciesReference
stoichiometry: 1.0
species: 638478

638478
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1-Acylglycerol-VLDL-PC-pool_c

702040
type: Reaction
is: K00128
is: ENSMUSG00000035561
is: ENSMUSG00000010025
is: R01752
is: ENSMUSG00000053279
reactant: 702064
product: 702088
name: r0392
is: ENSMUSG00000026687
product: 702100
reactant: 702052
reversible: true
is: K00149
reactant: 702076
is: ENSMUSG00000053644
fast: false
notes: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is: K14085

702064
type: SpeciesReference
stoichiometry: 1.0
species: 624403

702088
type: SpeciesReference
stoichiometry: 1.0
species: 629503

629503
type: Species
initial amount: NaN
is: CHEBI:32398
is: http://identifiers.org/pubchem.compound/3557
boundary condition: false
has only substance units: false
is: C00258
is: http://identifiers.org/cas/473-81-4
constant: false
in compartment: 623911
name: Glycerate_c
initial concentration: 2.6E-4

702100
type: SpeciesReference
stoichiometry: 1.0
species: 624451

702052
type: SpeciesReference
stoichiometry: 1.0
species: 631638

631638
type: Species
initial concentration: 2.6E-4
has only substance units: false
is: http://identifiers.org/pubchem.compound/3856
is: CHEBI:17378
name: Glyceraldehyde_c
constant: false
boundary condition: false
is: http://identifiers.org/cas/453-17-8
is: C00577
in compartment: 623911
initial amount: NaN

702076
type: SpeciesReference
stoichiometry: 1.0
species: 624259

696209
type: Reaction
is: R01224
fast: false
reactant: 696233
reversible: true
notes: 5-methyltetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
is: ENSMUSG00000029009
product: 696257
product: 696245
reactant: 696221
name: r0296
is: K00297

696233
type: SpeciesReference
stoichiometry: 1.0
species: 624547

696257
type: SpeciesReference
stoichiometry: 1.0
species: 624499

696245
type: SpeciesReference
stoichiometry: 1.0
species: 627991

627991
type: Species
is: http://identifiers.org/pubchem.compound/3443
initial amount: NaN
name: 5,10-Methylene-THF_c
has only substance units: false
boundary condition: false
is: C00143
is: http://identifiers.org/cas/3432-99-3
constant: false
initial concentration: 2.6E-4
is: CHEBI:1989
in compartment: 623911

696221
type: SpeciesReference
stoichiometry: 1.0
species: 631002

631002
type: Species
in compartment: 623911
initial amount: NaN
initial concentration: 2.6E-4
has only substance units: false
is: C00440
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3729
name: 5-Methyl-THF_c
is: CHEBI:15641
is: http://identifiers.org/cas/134-35-0

676355
type: Constraint
message: Error: Species concentration Collagen_CO6A3_c is out of the hard bounds.

640386
type: Species
name: prostaglandin-g2_s
constant: false
is: C05956
is: CHEBI:27647
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/51982-36-6
initial amount: NaN
in compartment: 623935
boundary condition: false
is: http://identifiers.org/pubchem.compound/8240

707946
type: Reaction
notes: Acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase Glutamate metabolism / Aminosugars metabolism EC:2.3.1.4
reactant: 707970
product: 707982
reactant: 707958
fast: false
product: 707994
is: K00621
reversible: false
is: ENSMUSG00000037722
name: r0485
is: R02058

707970
type: SpeciesReference
stoichiometry: 1.0
species: 625255

707982
type: SpeciesReference
stoichiometry: 1.0
species: 624799

707958
type: SpeciesReference
stoichiometry: 1.0
species: 630343

707994
type: SpeciesReference
stoichiometry: 1.0
species: 630403

630403
type: Species
constant: false
boundary condition: false
initial concentration: 2.6E-4
has only substance units: false
in compartment: 623911
is: C00357
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3650
is: CHEBI:15784
name: N-Acetylglucosamine-6P_c

752147
type: Reaction
notes: Pool reaction
product: 752219
name: r1208
fast: false
reactant: 752159
reactant: 752207
reversible: false
reactant: 752171
reactant: 752183
reactant: 752195

752219
type: SpeciesReference
stoichiometry: 7728.0
species: 638118

638118
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Acyl-CoA-VLDL-PS-pool_c

752159
type: SpeciesReference
stoichiometry: 345.0
species: 628231

752207
type: SpeciesReference
stoichiometry: 181.0
species: 637351

752171
type: SpeciesReference
stoichiometry: 4820.0
species: 630858

630858
type: Species
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3702
has only substance units: false
is: C00412
is: http://identifiers.org/cas/362-66-3
constant: false
name: Stearoyl-CoA_c
in compartment: 623911
is: CHEBI:15541
initial concentration: 2.6E-4

752183
type: SpeciesReference
stoichiometry: 332.0
species: 631338

631338
type: Species
in compartment: 623911
has only substance units: false
initial amount: NaN
name: Oleoyl-CoA_c
is: http://identifiers.org/pubchem.compound/3793
constant: false
is: C00510
boundary condition: false
is: CHEBI:15534
initial concentration: 2.6E-4

752195
type: SpeciesReference
stoichiometry: 2050.0
species: 637423

637423
type: Species
has only substance units: false
is: http://identifiers.org/cas/17046-56-9
constant: false
name: Arachidonyl-CoA_c
boundary condition: false
is: C02249
is: http://identifiers.org/pubchem.compound/5312
initial amount: NaN
initial concentration: 2.6E-4
is: CHEBI:15514
in compartment: 623911

653414
type: Constraint
message: Error: Species concentration dGTP_c is out of the hard bounds.

727580
type: Reaction
product: 727616
reactant: 727592
reactant: 727604
notes: TCDB:2.A.57 TCDB:2.A.41.2.3 TCDB:2.A.41.2.4
fast: false
is: ENSMUSG00000025726
is: ENSMUSG00000027219
name: r0810
product: 727628
reversible: false

727616
type: SpeciesReference
stoichiometry: 1.0
species: 633079

727592
type: SpeciesReference
stoichiometry: 1.0
species: 633091

727604
type: SpeciesReference
stoichiometry: 1.0
species: 628951

727628
type: SpeciesReference
stoichiometry: 1.0
species: 628939

628939
type: Species
is: http://identifiers.org/pubchem.compound/3512
is: http://identifiers.org/cas/58-61-7
in compartment: 623911
initial concentration: 2.6E-4
is: CHEBI:16335
has only substance units: false
is: C00212
initial amount: NaN
constant: false
name: Adenosine_c
boundary condition: false

704358
type: Reaction
notes: S-Adenosylmethioninamine:putrescine 3-aminopropyltransferase Urea cycle and metabolism of amino groups / Methionine metabolism EC:2.5.1.16
is: K00797
product: 704394
is: ENSMUSG00000006442
is: R01920
name: r0429
reversible: true
product: 704406
reactant: 704370
reactant: 704382
fast: false

704394
type: SpeciesReference
stoichiometry: 1.0
species: 628471

628471
type: Species
is: C00170
is: http://identifiers.org/cas/2457-80-9
initial concentration: 2.6E-4
is: CHEBI:17509
in compartment: 623911
initial amount: NaN
boundary condition: true
has only substance units: false
name: 5-Methylthioadenosine_c
constant: false
is: http://identifiers.org/pubchem.compound/3470

704406
type: SpeciesReference
stoichiometry: 1.0
species: 629947

629947
type: Species
is: C00315
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3609
initial amount: NaN
is: CHEBI:16610
constant: false
name: Spermidine_c
in compartment: 623911
boundary condition: false
has only substance units: false
is: http://identifiers.org/cas/124-20-9

704370
type: SpeciesReference
stoichiometry: 1.0
species: 632791

632791
type: Species
is: C01137
initial amount: NaN
is: CHEBI:15625
in compartment: 623911
constant: false
initial concentration: 2.6E-4
has only substance units: false
boundary condition: true
name: S-Adenosylmethioninamine_c
is: http://identifiers.org/pubchem.compound/4368

704382
type: SpeciesReference
stoichiometry: 1.0
species: 627799

627799
type: Species
is: CHEBI:17148
is: http://identifiers.org/pubchem.compound/3434
initial concentration: 2.6E-4
boundary condition: false
in compartment: 623911
is: C00134
is: http://identifiers.org/cas/110-60-1
constant: false
has only substance units: false
initial amount: NaN
name: Putrescine_c

636811
type: Species
name: Linolenate_s
initial amount: NaN
boundary condition: false
is: C06427
is: http://identifiers.org/cas/463-40-1
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/8662
is: CHEBI:27432
constant: false
in compartment: 623935
has only substance units: false

851051
type: Reaction
product: 851099
product: 851087
reactant: 851075
reactant: 851063
notes: Utilized transport
fast: false
reversible: true
name: r2511

851099
type: SpeciesReference
stoichiometry: 1.0
species: 633247

633247
type: Species
name: Linoleate_r
is: C01595
constant: false
is: CHEBI:17351
has only substance units: false
boundary condition: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/60-33-3
in compartment: 623923
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4750

851087
type: SpeciesReference
stoichiometry: 1.0
species: 629983

851075
type: SpeciesReference
stoichiometry: 1.0
species: 633259

633259
type: Species
in compartment: 623911
boundary condition: false
initial concentration: 2.6E-4
is: C01595
is: http://identifiers.org/pubchem.compound/4750
constant: false
is: CHEBI:17351
has only substance units: false
is: http://identifiers.org/cas/60-33-3
initial amount: NaN
name: Linoleate_c

851063
type: SpeciesReference
stoichiometry: 1.0
species: 629971

629971
type: Species
constant: false
is: CHEBI:16347
in compartment: 623923
name: L-Carnitine_r
has only substance units: false
boundary condition: false
initial amount: NaN
is: http://identifiers.org/cas/541-15-1
is: http://identifiers.org/pubchem.compound/3612
is: C00318
initial concentration: 2.6E-4

663889
type: Constraint
message: Warning: Species concentration 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanate_c is out of the soft bounds.

676751
type: Constraint
message: Warning: Species concentration Collagen_COGA1_c is out of the soft bounds.

625375
type: Species
in compartment: 623899
has only substance units: false
initial amount: NaN
is: http://identifiers.org/cas/328-50-7
is: http://identifiers.org/pubchem.compound/3328
initial concentration: 5.5E-4
constant: false
is: C00026
name: AKG_p
is: CHEBI:30915
boundary condition: false

735366
type: Reaction
product: 735414
product: 735402
reactant: 735390
reactant: 735378
notes: TCDB:1.D.6.1.1
fast: false
reversible: false
name: r0977

735414
type: SpeciesReference
stoichiometry: 1.0
species: 626647

735402
type: SpeciesReference
stoichiometry: 1.0
species: 632683

632683
type: Species
is: C01089
boundary condition: false
name: (R)-3-Hydroxybutanoate_m
initial amount: NaN
in compartment: 623863
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/4324
has only substance units: false
constant: false
is: CHEBI:10983

735390
type: SpeciesReference
stoichiometry: 1.0
species: 626623

735378
type: SpeciesReference
stoichiometry: 1.0
species: 632659

632659
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4324
is: CHEBI:10983
in compartment: 623911
has only substance units: false
boundary condition: false
constant: false
is: C01089
name: (R)-3-Hydroxybutanoate_c
initial concentration: 2.6E-4

677207
type: Constraint
message: Warning: Species concentration Collagen_ITA1_c is out of the soft bounds.

818520
type: Reaction
reactant: 818544
product: 818556
reactant: 818532
fast: false
reversible: false
product: 818568
name: r2053
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: ENSMUSG00000030492

818544
type: SpeciesReference
stoichiometry: 1.0
species: 628699

818556
type: SpeciesReference
stoichiometry: 1.0
species: 627835

818532
type: SpeciesReference
stoichiometry: 1.0
species: 627847

818568
type: SpeciesReference
stoichiometry: 1.0
species: 628711

664777
type: Constraint
message: Warning: Species concentration 3-Oxooctanoyl-CoA_m is out of the soft bounds.

802203
type: Reaction
reactant: 802227
reversible: false
reactant: 802215
notes: Y+LAT2 Utilized transport
product: 802275
is: ENSMUSG00000031904
name: r1842
fast: false
product: 802251
product: 802263
reactant: 802239

802227
type: SpeciesReference
stoichiometry: 1.0
species: 626539

802215
type: SpeciesReference
stoichiometry: 1.0
species: 628159

628159
type: Species
name: Asparagine_s
boundary condition: true
is: C00152
constant: false
in compartment: 623935
is: http://identifiers.org/cas/70-47-3
initial concentration: 2.6E-4
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3452
is: CHEBI:17196

802275
type: SpeciesReference
stoichiometry: 1.0
species: 633079

802251
type: SpeciesReference
stoichiometry: 1.0
species: 628147

802263
type: SpeciesReference
stoichiometry: 1.0
species: 626551

802239
type: SpeciesReference
stoichiometry: 1.0
species: 633091

661585
type: Constraint
message: Warning: Species concentration Xanthurenate_s is out of the soft bounds.

652358
type: Constraint
message: Error: Species concentration Succinate_semialdehyde_m is out of the hard bounds.

671592
type: Constraint
message: Warning: Species concentration 3-Oxostearoyl-ACP_c is out of the soft bounds.

655274
type: Constraint
message: Warning: Species concentration Urate_p is out of the soft bounds.

847319
type: Reaction
product: 847355
notes: Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.6
fast: false
is: ENSMUSG00000021553
product: 847367
reactant: 847331
name: r2458
reactant: 847343
reversible: false

847355
type: SpeciesReference
stoichiometry: 1.0
species: 631578

631578
type: Species
boundary condition: false
is: http://identifiers.org/cas/958-09-8
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3839
in compartment: 623911
initial concentration: 2.6E-4
is: CHEBI:17256
initial amount: NaN
is: C00559
name: Deoxyadenosine_c

847367
type: SpeciesReference
stoichiometry: 2.0
species: 633079

847331
type: SpeciesReference
stoichiometry: 1.0
species: 631590

631590
type: Species
initial concentration: 2.6E-4
is: http://identifiers.org/cas/958-09-8
initial amount: NaN
is: C00559
in compartment: 623935
is: CHEBI:17256
is: http://identifiers.org/pubchem.compound/3839
name: Deoxyadenosine_s
boundary condition: true
constant: false
has only substance units: false

847343
type: SpeciesReference
stoichiometry: 2.0
species: 633091

640662
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: palmitoleoyl-Carnitine_m

728347
type: Reaction
product: 728371
reactant: 728359
notes: GLUT-8 Transport reaction
is: ENSMUSG00000026791
fast: false
reversible: false
name: r0824

728371
type: SpeciesReference
stoichiometry: 1.0
species: 627607

627607
type: Species
initial concentration: 2.6E-4
constant: false
in compartment: 623911
is: http://identifiers.org/pubchem.compound/3424
is: http://identifiers.org/cas/59-23-4
name: Galactose_c
is: CHEBI:4139
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00124

728359
type: SpeciesReference
stoichiometry: 1.0
species: 627619

627619
type: Species
is: C00124
name: Galactose_s
is: CHEBI:4139
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 2.6E-4
boundary condition: true
is: http://identifiers.org/cas/59-23-4
in compartment: 623935
is: http://identifiers.org/pubchem.compound/3424

825035
type: Reaction
is: ENSMUSG00000079262
product: 825107
fast: false
is: ENSMUSG00000063975
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: 825083
is: ENSMUSG00000030237
name: r2156
product: 825095
reactant: 825071
reactant: 825059
reactant: 825047
reversible: true
is: ENSMUSG00000041698

825107
type: SpeciesReference
stoichiometry: 1.0
species: 640002

825083
type: SpeciesReference
stoichiometry: 1.0
species: 633523

825095
type: SpeciesReference
stoichiometry: 1.0
species: 629731

825071
type: SpeciesReference
stoichiometry: 1.0
species: 639990

825059
type: SpeciesReference
stoichiometry: 1.0
species: 629719

825047
type: SpeciesReference
stoichiometry: 1.0
species: 633535

633535
type: Species
initial amount: NaN
has only substance units: false
is: C01921
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/5027
name: Glycocholate_s
in compartment: 623935
is: CHEBI:17687
constant: false
boundary condition: true
is: http://identifiers.org/cas/475-31-0

624031
type: Species
is: P01009
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623935
name: Antitrypsin_s

730183
type: Reaction
product: 730207
reactant: 730195
notes: Facilitated diffusion
fast: false
reversible: true
name: r0863

730207
type: SpeciesReference
stoichiometry: 1.0
species: 624811

730195
type: SpeciesReference
stoichiometry: 1.0
species: 624799

667500
type: Constraint
message: Error: Species concentration S-Glutaryldihydrolipoamide_m is out of the hard bounds.

667956
type: Constraint
message: Error: Species concentration Fe2+_c is out of the hard bounds.

653954
type: Constraint
message: Warning: Species concentration Pyridoxine_s is out of the soft bounds.

746927
type: Reaction
notes: Major Facilitator(MFS) TCDB:2.A.18.6.5
fast: false
reactant: 746951
product: 746963
name: r1122
reversible: true
is: ENSMUSG00000022462
product: 746975
reactant: 746939

746951
type: SpeciesReference
stoichiometry: 1.0
species: 633079

746963
type: SpeciesReference
stoichiometry: 1.0
species: 627571

746975
type: SpeciesReference
stoichiometry: 1.0
species: 633091

746939
type: SpeciesReference
stoichiometry: 1.0
species: 627559

639366
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: LacCer-pool_r

664813
type: Constraint
message: Error: Species concentration 3-Oxohexanoyl-CoA_m is out of the hard bounds.

644849
type: Constraint
message: Error: Species concentration H2O2_m is out of the hard bounds.

661333
type: Constraint
message: Error: Species concentration Methylmalonate_c is out of the hard bounds.

722024
type: Reaction
is: K07515
is: K00022
reactant: 722048
product: 722060
is: ENSMUSG00000025745
notes: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is: ENSMUSG00000027984
is: K01782
product: 722072
fast: false
reactant: 722036
name: r0714
is: R04737
is: K07514
reversible: false
is: K01825
is: K07516
is: ENSMUSG00000022853

722048
type: SpeciesReference
stoichiometry: 1.0
species: 635143

635143
type: Species
constant: false
has only substance units: false
name: (S)-3-Hydroxyhexadecanoyl-CoA_m
initial concentration: 1.0E-5
is: http://identifiers.org/pubchem.compound/7645
is: C05258
is: CHEBI:27402
initial amount: NaN
boundary condition: false
in compartment: 623863

722060
type: SpeciesReference
stoichiometry: 1.0
species: 635167

635167
type: Species
initial amount: NaN
initial concentration: 1.0E-5
has only substance units: false
name: 3-Oxopalmitoyl-CoA_m
is: http://identifiers.org/pubchem.compound/7646
in compartment: 623863
constant: false
is: C05259
boundary condition: false
is: CHEBI:15491

722072
type: SpeciesReference
stoichiometry: 1.0
species: 624463

722036
type: SpeciesReference
stoichiometry: 1.0
species: 624415

682612
type: Reaction
notes: L-Glutamate:ammonia ligase (ADP-forming) Glutamate metabolism / Nitrogen metabolism EC:6.3.1.2
name: r0077
is: K01915
product: 682672
fast: false
is: ENSMUSG00000026473
reactant: 682648
product: 682660
is: R00253
reversible: false
product: 682684
reactant: 682624
reactant: 682636

682672
type: SpeciesReference
stoichiometry: 1.0
species: 624727

682648
type: SpeciesReference
stoichiometry: 1.0
species: 624979

624979
type: Species
is: CHEBI:16134
boundary condition: false
is: C00014
name: NH3_c
is: http://identifiers.org/cas/7664-41-7
has only substance units: false
initial concentration: 5.25E-4
initial amount: NaN
in compartment: 623911
constant: false
is: http://identifiers.org/pubchem.compound/3316

682660
type: SpeciesReference
stoichiometry: 1.0
species: 624655

682684
type: SpeciesReference
stoichiometry: 1.0
species: 626251

682624
type: SpeciesReference
stoichiometry: 1.0
species: 624331

682636
type: SpeciesReference
stoichiometry: 1.0
species: 625291

644765
type: Constraint
message: Warning: Species concentration AKG_m is out of the soft bounds.

667044
type: Constraint
message: Error: Species concentration Bilirubin-bisglucuronoside_r is out of the hard bounds.

634183
type: Species
is: C03344
constant: false
is: CHEBI:15476
initial concentration: 2.6E-4
in compartment: 623863
name: 2-Methylacetoacetyl-CoA_m
boundary condition: false
is: http://identifiers.org/pubchem.compound/6187
initial amount: NaN
has only substance units: false

702448
type: Reaction
reactant: 702460
product: 702496
fast: false
reactant: 702472
product: 702484
notes: NADPH:6,7-dihydropteridine oxidoreductase Folate biosynthesis EC:1.5.1.34
reversible: true
is: R01794
is: K00357
name: r0398
is: ENSMUSG00000015806

702460
type: SpeciesReference
stoichiometry: 1.0
species: 629575

629575
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: http://identifiers.org/pubchem.compound/5460203
initial concentration: 2.6E-4
constant: false
is: C00268
name: Dihydrobiopterin_c
in compartment: 623911

702496
type: SpeciesReference
stoichiometry: 1.0
species: 624547

702472
type: SpeciesReference
stoichiometry: 1.0
species: 624499

702484
type: SpeciesReference
stoichiometry: 1.0
species: 629611

629611
type: Species
constant: false
has only substance units: false
initial concentration: 2.6E-4
in compartment: 623911
name: Tetrahydrobiopterin_c
is: http://identifiers.org/pubchem.compound/3570
is: CHEBI:15372
initial amount: NaN
is: C00272
boundary condition: false
is: http://identifiers.org/cas/17528-72-2

669168
type: Constraint
message: Warning: Species concentration PE-VLDL-pool_b is out of the soft bounds.

724628
type: Reaction
notes: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is: ENSMUSG00000075296
product: 724676
fast: false
is: ENSMUSG00000024885
reactant: 724652
product: 724688
is: ENSMUSG00000019102
reactant: 724640
name: r0757
is: ENSMUSG00000015134
reversible: true
reactant: 724664
is: R04892
is: K00129

724676
type: SpeciesReference
stoichiometry: 1.0
species: 624511

724652
type: SpeciesReference
stoichiometry: 1.0
species: 624295

724688
type: SpeciesReference
stoichiometry: 1.0
species: 636115

636115
type: Species
is: C05584
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/55-10-7
constant: false
name: Vanillylmandelate_m
initial amount: NaN
in compartment: 623863
is: http://identifiers.org/pubchem.compound/7910
boundary condition: false

724640
type: SpeciesReference
stoichiometry: 1.0
species: 636103

636103
type: Species
is: C05583
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde_m
has only substance units: false
is: http://identifiers.org/pubchem.compound/7909
constant: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
boundary condition: false

724664
type: SpeciesReference
stoichiometry: 1.0
species: 624559

641826
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623899
name: CoA-activated_acetyl_group_p

672360
type: Constraint
message: Warning: Species concentration THF-hexaglutamate_c is out of the soft bounds.

718288
type: Reaction
reactant: 718312
is: ENSMUSG00000010651
reactant: 718300
is: K07513
product: 718324
notes: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
reversible: true
is: ENSMUSG00000036138
is: K07509
name: r0654
is: K00632
is: R03991
product: 718336
is: K07508

718312
type: SpeciesReference
stoichiometry: 1.0
species: 625279

625279
type: Species
is: C00024
is: http://identifiers.org/cas/72-89-9
is: http://identifiers.org/pubchem.compound/3326
initial concentration: 5.05E-4
in compartment: 623899
initial amount: NaN
has only substance units: false
constant: false
name: Acetyl-CoA_p
boundary condition: false
is: CHEBI:15351

718300
type: SpeciesReference
stoichiometry: 1.0
species: 633907

633907
type: Species
initial concentration: 2.6E-4
initial amount: NaN
is: C02593
constant: false
is: http://identifiers.org/pubchem.compound/5585
name: Myristoyl-CoA_p
has only substance units: false
is: CHEBI:15532
in compartment: 623899
boundary condition: false

718324
type: SpeciesReference
stoichiometry: 1.0
species: 624823

624823
type: Species
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3312
initial amount: NaN
is: C00010
constant: false
name: CoA_p
is: CHEBI:15346
boundary condition: false
in compartment: 623899
is: http://identifiers.org/cas/85-61-0

718336
type: SpeciesReference
stoichiometry: 1.0
species: 635179

738642
type: Reaction
product: 738666
reactant: 738654
notes: Zinc (Zn$^{2+}$)-Iron (Fe$^{2+}$) Permease (ZIP) TCDB:2.A.57.1.1
is: ENSMUSG00000023942
fast: false
reversible: true
name: r1040

738666
type: SpeciesReference
stoichiometry: 1.0
species: 630727

630727
type: Species
initial amount: NaN
is: CHEBI:16750
is: http://identifiers.org/pubchem.compound/3677
is: C00387
name: Guanosine_m
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
constant: false
is: http://identifiers.org/cas/118-00-3
in compartment: 623863

738654
type: SpeciesReference
stoichiometry: 1.0
species: 630703

630703
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3677
has only substance units: false
constant: false
is: http://identifiers.org/cas/118-00-3
is: C00387
boundary condition: false
in compartment: 623911
initial concentration: 2.6E-4
is: CHEBI:16750
name: Guanosine_c

641790
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623863
name: THF-activated_formyl_group_m

787026
type: Reaction
reactant: 787050
name: r1657
is: ENSMUSG00000040010
product: 787062
product: 787074
reactant: 787038
reversible: true
fast: false
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

787050
type: SpeciesReference
stoichiometry: 1.0
species: 628699

787062
type: SpeciesReference
stoichiometry: 1.0
species: 628531

787074
type: SpeciesReference
stoichiometry: 1.0
species: 628711

787038
type: SpeciesReference
stoichiometry: 1.0
species: 628543

676559
type: Constraint
message: Warning: Species concentration Collagen_CO9A3_c is out of the soft bounds.

700720
type: Reaction
is: K00615
notes: Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase Pentose phosphate pathway EC:2.2.1.1
fast: false
reactant: 700744
product: 700756
is: ENSMUSG00000021957
product: 700768
reversible: true
name: r0370
reactant: 700732
is: R01641

700744
type: SpeciesReference
stoichiometry: 1.0
species: 627475

627475
type: Species
name: GAP_c
is: CHEBI:29052
is: C00118
constant: false
is: http://identifiers.org/pubchem.compound/3418
boundary condition: false
initial amount: NaN
is: http://identifiers.org/cas/591-57-1
has only substance units: false
in compartment: 623911
initial concentration: 5.05E-4

700756
type: SpeciesReference
stoichiometry: 1.0
species: 627463

627463
type: Species
is: http://identifiers.org/cas/4151-19-3
initial concentration: 5.05E-4
is: http://identifiers.org/pubchem.compound/3417
is: C00117
in compartment: 623911
name: Ribose-5P_c
boundary condition: false
constant: false
is: CHEBI:17797
has only substance units: false
initial amount: NaN

700768
type: SpeciesReference
stoichiometry: 1.0
species: 629131

629131
type: Species
is: http://identifiers.org/pubchem.compound/3530
is: C00231
boundary condition: false
is: CHEBI:16332
constant: false
initial concentration: 2.6E-4
has only substance units: false
name: D-Xylulose-5P_c
initial amount: NaN
in compartment: 623911

700732
type: SpeciesReference
stoichiometry: 1.0
species: 635623

635623
type: Species
initial concentration: 2.6E-4
has only substance units: false
is: CHEBI:15721
initial amount: NaN
boundary condition: false
in compartment: 623911
constant: false
is: http://identifiers.org/pubchem.compound/7756
is: C05382
name: Sedoheptulose-7P_c

677963
type: Reaction
product: 677987
reactant: 677975
notes: Active transport
fast: false
reversible: true
name: r0002

677987
type: SpeciesReference
stoichiometry: 1.0
species: 629971

677975
type: SpeciesReference
stoichiometry: 1.0
species: 629983

627343
type: Species
has only substance units: false
in compartment: 623935
name: CDP_s
is: CHEBI:17239
initial amount: NaN
is: http://identifiers.org/cas/63-38-7
boundary condition: true
initial concentration: 2.6E-4
is: C00112
is: http://identifiers.org/pubchem.compound/3412
constant: false

674256
type: Constraint
message: Warning: Species concentration prostaglandin-b2_c is out of the soft bounds.

749820
type: Reaction
reactant: 749832
reversible: false
product: 749856
notes: EC:3.1.1.13
is: ENSMUSG00000026818
is: ENSMUSG00000024781
name: r1174
fast: false
reactant: 749844
product: 749868

749832
type: SpeciesReference
stoichiometry: 1.0
species: 637807

749856
type: SpeciesReference
stoichiometry: 1.0
species: 628639

749844
type: SpeciesReference
stoichiometry: 1.0
species: 624247

624247
type: Species
name: H2O_r
is: C00001
initial amount: NaN
constant: false
is: CHEBI:15377
is: http://identifiers.org/pubchem.compound/3303
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/cas/7732-18-5
in compartment: 623923

749868
type: SpeciesReference
stoichiometry: 1.0
species: 637291

637291
type: Species
initial amount: NaN
in compartment: 623923
is: http://identifiers.org/cas/373-49-9
initial concentration: 2.6E-4
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/10558
has only substance units: false
name: Palmitolate_r
is: C08362
is: CHEBI:28716

628747
type: Species
is: http://identifiers.org/pubchem.compound/3489
has only substance units: false
initial amount: NaN
in compartment: 623911
initial concentration: 2.6E-4
boundary condition: true
is: C00189
name: Ethanolamine_c
constant: false
is: CHEBI:16000
is: http://identifiers.org/cas/141-43-5

660517
type: Constraint
message: Error: Species concentration Stearate_s is out of the hard bounds.

659905
type: Constraint
message: Warning: Species concentration Nicotinate_ribonucleotide_c is out of the soft bounds.

658154
type: Constraint
message: Warning: Species concentration dCDP_c is out of the soft bounds.

646718
type: Constraint
message: Warning: Species concentration Serine_m is out of the soft bounds.

748583
type: Reaction
reactant: 748607
reactant: 748619
product: 748631
notes: EC:1.2.7.2
fast: false
product: 748643
reactant: 748595
name: r1154
reversible: true
product: 748655

748607
type: SpeciesReference
stoichiometry: 1.0
species: 624415

748619
type: SpeciesReference
stoichiometry: 1.0
species: 627283

627283
type: Species
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3409
initial amount: NaN
boundary condition: false
name: 2-Oxobutyrate_m
constant: false
is: http://identifiers.org/cas/600-18-0
is: C00109
is: CHEBI:30831
in compartment: 623863

748631
type: SpeciesReference
stoichiometry: 1.0
species: 624883

748643
type: SpeciesReference
stoichiometry: 1.0
species: 627103

627103
type: Species
is: C00100
is: http://identifiers.org/pubchem.compound/3400
is: http://identifiers.org/cas/317-66-8
boundary condition: false
name: Propanoyl-CoA_m
constant: false
in compartment: 623863
has only substance units: false
initial amount: NaN
initial concentration: 2.6E-4
is: CHEBI:15539

748595
type: SpeciesReference
stoichiometry: 1.0
species: 624811

748655
type: SpeciesReference
stoichiometry: 1.0
species: 624463

625243
type: Species
is: http://identifiers.org/pubchem.compound/3326
name: Acetyl-CoA_r
boundary condition: false
is: http://identifiers.org/cas/72-89-9
initial concentration: 5.05E-4
constant: false
is: C00024
initial amount: NaN
in compartment: 623923
has only substance units: false
is: CHEBI:15351

716632
type: Reaction
is: R03719
product: 716668
product: 716680
reactant: 716656
name: r0628
notes: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
is: K08764
reactant: 716644
reversible: true
fast: false
is: ENSMUSG00000028603

716668
type: SpeciesReference
stoichiometry: 1.0
species: 624823

716680
type: SpeciesReference
stoichiometry: 1.0
species: 635995

635995
type: Species
is: http://identifiers.org/pubchem.compound/7827
has only substance units: false
in compartment: 623899
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:27379
is: C05467
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-24-oxocholestanoyl-CoA_p
initial concentration: 2.6E-4

716656
type: SpeciesReference
stoichiometry: 1.0
species: 633427

633427
type: Species
is: C01794
boundary condition: false
constant: false
name: Choloyl-CoA_p
is: CHEBI:15519
in compartment: 623899
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4921
has only substance units: false
initial concentration: 2.6E-4

716644
type: SpeciesReference
stoichiometry: 1.0
species: 627115

633223
type: Species
constant: false
initial amount: NaN
initial concentration: 2.6E-4
boundary condition: true
is: C01530
is: CHEBI:25629
name: Stearate_s
has only substance units: false
is: http://identifiers.org/pubchem.compound/4692
is: http://identifiers.org/cas/57-11-4
in compartment: 623935

624391
type: Species
is: CHEBI:15846
boundary condition: false
initial concentration: 8.87E-5
constant: false
is: http://identifiers.org/cas/53-84-9
has only substance units: false
is: C00003
in compartment: 623923
is: http://identifiers.org/pubchem.compound/3305
name: NAD+_r
initial amount: NaN

642222
type: Constraint
message: Warning: Species concentration ApoA1_l is out of the soft bounds.

660817
type: Constraint
message: Warning: Species concentration Lanosterol_r is out of the soft bounds.

649718
type: Constraint
message: Error: Species concentration Putrescine_m is out of the hard bounds.

662905
type: Constraint
message: Warning: Species concentration Dopamine_c is out of the soft bounds.

703650
type: Reaction
is: K13421
product: 703698
name: r0417
is: R01870
product: 703686
fast: false
is: K00762
notes: Orotidine-5'-phosphate:pyrophosphate phosphoribosyltransferase Pyrimidine metabolism EC:2.4.2.10
reversible: true
reactant: 703674
is: ENSMUSG00000022814
reactant: 703662

703698
type: SpeciesReference
stoichiometry: 1.0
species: 627487

627487
type: Species
constant: false
in compartment: 623911
boundary condition: false
is: http://identifiers.org/pubchem.compound/3419
is: C00119
is: CHEBI:17111
name: PRPP_c
initial concentration: 2.6E-4
initial amount: NaN
has only substance units: false

703686
type: SpeciesReference
stoichiometry: 1.0
species: 629779

629779
type: Species
is: C00295
has only substance units: false
name: Orotate_c
is: CHEBI:16742
boundary condition: false
is: http://identifiers.org/cas/65-86-1
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3589
in compartment: 623911
initial concentration: 2.6E-4

703674
type: SpeciesReference
stoichiometry: 1.0
species: 632719

632719
type: Species
is: http://identifiers.org/pubchem.compound/4337
constant: false
initial amount: NaN
initial concentration: 2.6E-4
boundary condition: false
name: Orotidine-5P_c
is: http://identifiers.org/cas/2149-82-8
in compartment: 623911
is: C01103
is: CHEBI:15842
has only substance units: false

703662
type: SpeciesReference
stoichiometry: 1.0
species: 624919

734695
type: Reaction
fast: false
product: 734743
reversible: false
product: 734731
reactant: 734707
reactant: 734719
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
is: ENSMUSG00000003617
name: r0961

734743
type: SpeciesReference
stoichiometry: 1.0
species: 633079

734731
type: SpeciesReference
stoichiometry: 1.0
species: 631242

631242
type: Species
is: http://identifiers.org/cas/635-65-4
initial concentration: 2.6E-4
has only substance units: false
is: C00486
is: CHEBI:16990
initial amount: NaN
boundary condition: false
name: Bilirubin_c
in compartment: 623911
is: http://identifiers.org/pubchem.compound/3769
constant: false

734707
type: SpeciesReference
stoichiometry: 1.0
species: 631254

631254
type: Species
constant: false
is: C00486
is: http://identifiers.org/pubchem.compound/3769
name: Bilirubin_s
initial amount: NaN
initial concentration: 2.6E-4
is: http://identifiers.org/cas/635-65-4
boundary condition: true
in compartment: 623935
is: CHEBI:16990
has only substance units: false

734719
type: SpeciesReference
stoichiometry: 1.0
species: 633091

677735
type: Constraint
message: Warning: Species concentration CoA-activated_acetyl_group_p is out of the soft bounds.

630451
type: Species
initial amount: NaN
is: C00362
is: CHEBI:16192
in compartment: 623911
boundary condition: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/902-04-5
constant: false
is: http://identifiers.org/pubchem.compound/3653
name: dGMP_c
has only substance units: false

647196
type: Constraint
message: Error: Species concentration Tryptophan_l is out of the hard bounds.

671460
type: Constraint
message: Error: Species concentration 1-Acylglycerol-3P-CL-pool_m is out of the hard bounds.

642726
type: Constraint
message: Warning: Species concentration ATP_s is out of the soft bounds.

640530
type: Species
name: Hexadecenal_c
boundary condition: false
initial amount: NaN
is: C06123
in compartment: 623911
constant: false
initial concentration: 2.6E-4
has only substance units: false
is: http://identifiers.org/pubchem.compound/8380

745423
type: Reaction
product: 745449
reactant: 745436
notes: Postulated transport reaction
fast: false
reversible: true
name: r1106

745449
type: SpeciesReference
stoichiometry: 1.0
species: 629479

629479
type: Species
is: CHEBI:17015
is: http://identifiers.org/cas/83-88-5
constant: false
is: C00255
initial amount: NaN
in compartment: 623911
name: Riboflavin_c
initial concentration: 2.6E-4
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3554

745436
type: SpeciesReference
stoichiometry: 1.0
species: 629491

629491
type: Species
is: http://identifiers.org/pubchem.compound/3554
constant: false
has only substance units: false
name: Riboflavin_s
boundary condition: true
in compartment: 623935
is: http://identifiers.org/cas/83-88-5
initial concentration: 2.6E-4
is: CHEBI:17015
initial amount: NaN
is: C00255

675432
type: Constraint
message: Warning: Species concentration linoleic-Carnitine_r is out of the soft bounds.

685793
type: Reaction
is: R00494
notes: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: ENSMUSG00000027603
is: ENSMUSG00000006345
reactant: 685805
product: 685829
product: 685841
is: K00681
reactant: 685817
reversible: true
is: ENSMUSG00000040471
is: ENSMUSG00000006344
name: r0130
fast: false

685805
type: SpeciesReference
stoichiometry: 1.0
species: 625927

685829
type: SpeciesReference
stoichiometry: 1.0
species: 625303

625303
type: Species
is: http://identifiers.org/cas/56-86-0
boundary condition: true
initial concentration: 0.015
in compartment: 623935
is: C00025
name: Glutamate_s
is: http://identifiers.org/pubchem.compound/3327
is: CHEBI:16015
constant: false
initial amount: NaN
has only substance units: false

685841
type: SpeciesReference
stoichiometry: 1.0
species: 633187

633187
type: Species
in compartment: 623935
initial amount: NaN
constant: false
is: C01419
has only substance units: false
is: CHEBI:4047
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/4606
is: http://identifiers.org/cas/19246-18-5
boundary condition: true
name: Cys-Gly_s

685817
type: SpeciesReference
stoichiometry: 1.0
species: 624271

831083
type: Reaction
product: 831131
reversible: true
is: ENSMUSG00000030236
reactant: 831095
reactant: 831107
fast: false
name: r2228
reactant: 831119
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: 831155
product: 831143

831131
type: SpeciesReference
stoichiometry: 1.0
species: 634759

831095
type: SpeciesReference
stoichiometry: 1.0
species: 634771

831107
type: SpeciesReference
stoichiometry: 1.0
species: 629719

831119
type: SpeciesReference
stoichiometry: 1.0
species: 639954

831155
type: SpeciesReference
stoichiometry: 1.0
species: 639966

831143
type: SpeciesReference
stoichiometry: 1.0
species: 629731

783281
type: Reaction
reactant: 783293
name: r1595
product: 783317
product: 783329
reversible: true
is: ENSMUSG00000040010
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: 783305

783293
type: SpeciesReference
stoichiometry: 1.0
species: 626311

783317
type: SpeciesReference
stoichiometry: 1.0
species: 626299

783329
type: SpeciesReference
stoichiometry: 1.0
species: 629563

783305
type: SpeciesReference
stoichiometry: 1.0
species: 629551

639234
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: L-Oleoylcarnitine_c

784901
type: Reaction
is: ENSMUSG00000040010
reactant: 784925
reactant: 784913
name: r1622
product: 784937
reversible: true
product: 784949
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

784925
type: SpeciesReference
stoichiometry: 1.0
species: 628147

784913
type: SpeciesReference
stoichiometry: 1.0
species: 626587

784937
type: SpeciesReference
stoichiometry: 1.0
species: 626575

784949
type: SpeciesReference
stoichiometry: 1.0
species: 628159

833833
type: Reaction
is: ENSMUSG00000030236
reactant: 833857
product: 833881
reactant: 833845
product: 833893
reactant: 833869
product: 833905
reversible: true
fast: false
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
name: r2260

833857
type: SpeciesReference
stoichiometry: 1.0
species: 629719

833881
type: SpeciesReference
stoichiometry: 1.0
species: 640038

640038
type: Species
name: prostaglandin-a2_c
constant: false
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/cas/13345-50-1
is: C05953
initial concentration: 2.6E-4
boundary condition: false
is: http://identifiers.org/pubchem.compound/8237
has only substance units: false
is: CHEBI:27820

833845
type: SpeciesReference
stoichiometry: 1.0
species: 640050

640050
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/8237
constant: false
is: C05953
is: http://identifiers.org/cas/13345-50-1
is: CHEBI:27820
initial amount: NaN
in compartment: 623935
has only substance units: false
initial concentration: 2.6E-4
name: prostaglandin-a2_s

833893
type: SpeciesReference
stoichiometry: 1.0
species: 629731

833869
type: SpeciesReference
stoichiometry: 1.0
species: 639918

833905
type: SpeciesReference
stoichiometry: 1.0
species: 639930

668112
type: Constraint
message: Warning: Species concentration Fibrinogen_l is out of the soft bounds.

657098
type: Constraint
message: Warning: Species concentration Methylglyoxal_s is out of the soft bounds.

644717
type: Constraint
message: Warning: Species concentration AKG_c is out of the soft bounds.

647232
type: Constraint
message: Warning: Species concentration Phenylalanine_c is out of the soft bounds.

638706
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: Phosphatidate-CL-pool_m

724064
type: Reaction
is: K00037
product: 724112
is: ENSMUSG00000033715
is: R04824
notes: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NAD+ oxidoreductase (B-specific) Bile acid biosynthesis EC:1.1.1.50
reactant: 724088
name: r0749
reactant: 724076
is: ENSMUSG00000021210
fast: false
product: 724100
is: ENSMUSG00000025955
is: ENSMUSG00000021214
is: ENSMUSG00000054757
is: ENSMUSG00000021207
reversible: true

724112
type: SpeciesReference
stoichiometry: 1.0
species: 635815

635815
type: Species
initial concentration: 2.6E-4
is: CHEBI:2288
constant: false
has only substance units: false
name: 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one_c
is: C05453
is: http://identifiers.org/pubchem.compound/7815
boundary condition: false
in compartment: 623911
initial amount: NaN

724088
type: SpeciesReference
stoichiometry: 1.0
species: 624403

724076
type: SpeciesReference
stoichiometry: 1.0
species: 635827

635827
type: Species
constant: false
in compartment: 623911
is: http://identifiers.org/cas/547-96-6
initial amount: NaN
is: C05454
name: 3alpha,7alpha,12alpha-Trihydroxycoprostane_c
has only substance units: false
initial concentration: 2.6E-4
is: CHEBI:16496
is: http://identifiers.org/pubchem.compound/7816
boundary condition: false

724100
type: SpeciesReference
stoichiometry: 1.0
species: 624451

709301
type: Reaction
is: ENSMUSG00000059534
notes: Ubiquinol:ferricytochrome-c oxidoreductase Oxidative phosphorylation EC:1.10.2.2
product: 709373
is: ENSMUSG00000030884
is: ENSMUSG00000025651
product: 709349
is: ENSMUSG00000063882
is: ENSMUSG00000021520
reactant: 709313
is: ENSMUSG00000044894
reactant: 709337
fast: false
is: ENSMUSG00000020163
product: 709361
name: r0507
reactant: 709325
is: R02161
is: ENSMUSG00000038462
reversible: false

709373
type: SpeciesReference
stoichiometry: 2.0
species: 627643

627643
type: Species
is: C00126
in compartment: 623863
name: Ferrocytochrome_C_m
is: http://identifiers.org/pubchem.compound/439171
has only substance units: false
boundary condition: false
initial concentration: 2.6E-4
initial amount: NaN
constant: false

709349
type: SpeciesReference
stoichiometry: 1.0
species: 630786

709313
type: SpeciesReference
stoichiometry: 1.0
species: 630774

709337
type: SpeciesReference
stoichiometry: 4.0
species: 626647

709361
type: SpeciesReference
stoichiometry: 4.0
species: 626623

709325
type: SpeciesReference
stoichiometry: 2.0
species: 627631

627631
type: Species
in compartment: 623863
is: http://identifiers.org/pubchem.compound/439171
has only substance units: false
boundary condition: false
is: C00125
initial concentration: 2.6E-4
initial amount: NaN
name: Ferricytochrome_C_m
constant: false

674796
type: Constraint
message: Error: Species concentration prostaglandin-f2beta_s is out of the hard bounds.

805454
type: Reaction
is: ENSMUSG00000031904
reactant: 805466
notes: Y+LAT2 Utilized transport
reversible: false
name: r1880
product: 805514
reactant: 805490
product: 805526
reactant: 805478
fast: false
product: 805502

805466
type: SpeciesReference
stoichiometry: 1.0
species: 628711

805514
type: SpeciesReference
stoichiometry: 1.0
species: 629563

805490
type: SpeciesReference
stoichiometry: 1.0
species: 633091

805526
type: SpeciesReference
stoichiometry: 1.0
species: 633079

805478
type: SpeciesReference
stoichiometry: 1.0
species: 629551

805502
type: SpeciesReference
stoichiometry: 1.0
species: 628699

657590
type: Constraint
message: Error: Species concentration 2,5-Dihydroxybenzoate_c is out of the hard bounds.

638670
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Acyl-CoA-CL-pool_c

668772
type: Constraint
message: Error: Species concentration Linoleoyl-CoA_c is out of the hard bounds.

706806
type: Reaction
is: ENSMUSG00000013629
reactant: 706830
reversible: true
is: K11540
is: R01993
fast: false
reactant: 706818
name: r0467
notes: (S)-Dihydroorotate amidohydrolase Pyrimidine metabolism EC:3.5.2.3
is: K01465
product: 706842

706830
type: SpeciesReference
stoichiometry: 1.0
species: 630235

630235
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/3630
name: (S)-Dihydroorotate_c
in compartment: 623911
initial concentration: 2.6E-4
initial amount: NaN
is: http://identifiers.org/cas/5988-19-2
has only substance units: false
constant: false
is: CHEBI:17025
is: C00337

706818
type: SpeciesReference
stoichiometry: 1.0
species: 624259

706842
type: SpeciesReference
stoichiometry: 1.0
species: 630978

655754
type: Constraint
message: Warning: Species concentration Isoleucine_m is out of the soft bounds.

832573
type: Reaction
product: 832645
product: 832621
is: ENSMUSG00000030236
product: 832633
reactant: 832597
fast: false
reversible: true
reactant: 832585
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
name: r2245
reactant: 832609

832645
type: SpeciesReference
stoichiometry: 1.0
species: 639930

832621
type: SpeciesReference
stoichiometry: 1.0
species: 639594

832633
type: SpeciesReference
stoichiometry: 1.0
species: 629731

832597
type: SpeciesReference
stoichiometry: 1.0
species: 629719

832585
type: SpeciesReference
stoichiometry: 1.0
species: 639606

832609
type: SpeciesReference
stoichiometry: 1.0
species: 639918

647133
type: Constraint
message: Warning: Species concentration Ornithine_m is out of the soft bounds.

629959
type: Species
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3609
initial amount: NaN
is: CHEBI:16610
constant: false
in compartment: 623935
boundary condition: true
has only substance units: false
name: Spermidine_s
is: http://identifiers.org/cas/124-20-9
is: C00315

674832
type: Constraint
message: Warning: Species concentration prostaglandin-g2_c is out of the soft bounds.

683249
type: Reaction
reactant: 683273
is: ENSMUSG00000018339
fast: false
reactant: 683261
is: ENSMUSG00000042808
product: 683285
is: K00432
is: ENSMUSG00000028597
name: r0087
is: ENSMUSG00000063856
product: 683297
reversible: false
notes: Glutathione:hydrogen-peroxide oxidoreductase Glutathione metabolism EC:1.11.1.9
is: ENSMUSG00000004341
is: ENSMUSG00000004344
is: R00274

683273
type: SpeciesReference
stoichiometry: 2.0
species: 625915

683261
type: SpeciesReference
stoichiometry: 1.0
species: 625387

683285
type: SpeciesReference
stoichiometry: 1.0
species: 627655

683297
type: SpeciesReference
stoichiometry: 2.0
species: 624259

723020
type: Reaction
product: 723068
name: r0732
is: ENSMUSG00000036880
is: K07509
reactant: 723044
fast: false
is: K00632
reversible: true
is: K07508
notes: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: R04747
reactant: 723032
product: 723056
is: ENSMUSG00000059447
is: K07513

723068
type: SpeciesReference
stoichiometry: 1.0
species: 635347

635347
type: Species
is: C05267
has only substance units: false
boundary condition: false
in compartment: 623863
is: CHEBI:28264
is: http://identifiers.org/pubchem.compound/7654
constant: false
name: 3-Oxooctanoyl-CoA_m
initial concentration: 1.0E-5
initial amount: NaN

723044
type: SpeciesReference
stoichiometry: 1.0
species: 625267

625267
type: Species
is: http://identifiers.org/pubchem.compound/3326
initial amount: NaN
constant: false
boundary condition: false
in compartment: 623863
is: CHEBI:15351
is: C00024
initial concentration: 5.05E-4
is: http://identifiers.org/cas/72-89-9
name: Acetyl-CoA_m
has only substance units: false

723032
type: SpeciesReference
stoichiometry: 1.0
species: 635383

635383
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7657
boundary condition: false
is: CHEBI:27540
constant: false
is: C05270
name: Hexanoyl-CoA_m
initial concentration: 2.6E-4
has only substance units: false
in compartment: 623863

723056
type: SpeciesReference
stoichiometry: 1.0
species: 624811

634435
type: Species
in compartment: 623911
initial concentration: 2.6E-4
has only substance units: false
is: C03785
initial amount: NaN
constant: false
is: CHEBI:4250
boundary condition: false
name: Tagatose-1,6PP_c
is: http://identifiers.org/pubchem.compound/6535

777594
type: Reaction
product: 777666
is: ENSMUSG00000042476
product: 777654
reactant: 777630
reactant: 777618
product: 777642
reactant: 777606
reversible: false
name: r1511
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.201.3
fast: false

777666
type: SpeciesReference
stoichiometry: 1.0
species: 624727

777654
type: SpeciesReference
stoichiometry: 1.0
species: 624655

777630
type: SpeciesReference
stoichiometry: 1.0
species: 624259

777618
type: SpeciesReference
stoichiometry: 1.0
species: 624331

777642
type: SpeciesReference
stoichiometry: 1.0
species: 638586

638586
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623887
name: Bile-PC-pool_b

777606
type: SpeciesReference
stoichiometry: 1.0
species: 638598

638598
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Bile-PC-pool_c

740454
type: Reaction
product: 740478
reactant: 740466
notes: Free diffusion
fast: false
reversible: true
name: r1087

740478
type: SpeciesReference
stoichiometry: 1.0
species: 625555

625555
type: Species
initial amount: NaN
is: CHEBI:15366
boundary condition: false
is: http://identifiers.org/cas/64-19-7
initial concentration: 2.6E-4
has only substance units: false
is: http://identifiers.org/pubchem.compound/3335
is: C00033
name: Acetate_m
in compartment: 623863
constant: false

740466
type: SpeciesReference
stoichiometry: 1.0
species: 625531

739806
type: Reaction
product: 739830
reactant: 739818
notes: Major Facilitator(MFS) TCDB:2.A.1.19.3
is: ENSMUSG00000018900
is: ENSMUSG00000063652
fast: false
reversible: true
name: r1069

739830
type: SpeciesReference
stoichiometry: 1.0
species: 625831

739818
type: SpeciesReference
stoichiometry: 1.0
species: 625819

651782
type: Constraint
message: Error: Species concentration dADP_c is out of the hard bounds.

628615
type: Species
is: C00186
is: http://identifiers.org/cas/79-33-4
in compartment: 623863
name: L-Lactate_m
is: CHEBI:422
is: http://identifiers.org/pubchem.compound/3486
boundary condition: false
constant: false
initial concentration: 2.6E-4
initial amount: NaN
has only substance units: false

755435
type: Reaction
is: ENSMUSG00000032883
product: 755495
is: ENSMUSG00000024207
is: ENSMUSG00000024981
name: r1256
reactant: 755447
reactant: 755471
is: ENSMUSG00000032281
notes: EC:6.2.1.3
fast: false
is: ENSMUSG00000020333
reactant: 755459
is: ENSMUSG00000031278
product: 755483
is: ENSMUSG00000027359
reversible: false
product: 755507
is: ENSMUSG00000018796

755495
type: SpeciesReference
stoichiometry: 1.0
species: 625135

755447
type: SpeciesReference
stoichiometry: 1.0
species: 624331

755471
type: SpeciesReference
stoichiometry: 1.0
species: 632059

632059
type: Species
is: C00712
name: Oleate_c
is: CHEBI:16196
is: http://identifiers.org/pubchem.compound/3978
in compartment: 623911
initial amount: NaN
boundary condition: false
initial concentration: 2.6E-4
constant: false
has only substance units: false
is: http://identifiers.org/cas/112-80-1

755459
type: SpeciesReference
stoichiometry: 1.0
species: 624799

755483
type: SpeciesReference
stoichiometry: 1.0
species: 631338

755507
type: SpeciesReference
stoichiometry: 1.0
species: 624919

671268
type: Constraint
message: Error: Species concentration Bile-PC-pool_c is out of the hard bounds.

894807
type: Reaction
product: 894855
product: 894843
reactant: 894831
reactant: 894819
notes: long-chain fatty-acyl-CoA hydrolase EC:3.1.2.2
fast: false
reversible: false
name: r2701

894855
type: SpeciesReference
stoichiometry: 1.0
species: 624787

624787
type: Species
is: http://identifiers.org/pubchem.compound/3312
name: CoA_r
in compartment: 623923
is: http://identifiers.org/cas/85-61-0
boundary condition: false
is: CHEBI:15346
has only substance units: false
initial amount: NaN
is: C00010
constant: false
initial concentration: 2.6E-4

894843
type: SpeciesReference
stoichiometry: 1.0
species: 636787

636787
type: Species
in compartment: 623923
initial amount: NaN
constant: false
initial concentration: 2.6E-4
is: C06427
has only substance units: false
is: http://identifiers.org/cas/463-40-1
boundary condition: false
is: CHEBI:27432
is: http://identifiers.org/pubchem.compound/8662
name: Linolenate_r

894831
type: SpeciesReference
stoichiometry: 1.0
species: 624247

894819
type: SpeciesReference
stoichiometry: 1.0
species: 637375

637375
type: Species
is: http://identifiers.org/pubchem.compound/47205472
has only substance units: false
in compartment: 623923
constant: false
boundary condition: false
is: C16162
initial concentration: 2.6E-4
name: Linolenoyl-CoA_r
initial amount: NaN

642270
type: Constraint
message: Warning: Species concentration ApoB100_c is out of the soft bounds.

658022
type: Constraint
message: Error: Species concentration Cholate_b is out of the hard bounds.

656930
type: Constraint
message: Warning: Species concentration NO_c is out of the soft bounds.

656690
type: Constraint
message: Warning: Species concentration Folate_s is out of the soft bounds.

684821
type: Reaction
reactant: 684845
name: r0112
is: ENSMUSG00000022110
is: K01902
fast: false
notes: Succinate:CoA ligase (ADP-forming) Citrate cycle (TCA cycle) / Propanoate metabolism EC:6.2.1.5
reactant: 684857
is: R00405
product: 684881
product: 684893
reversible: true
is: K01903
reactant: 684833
product: 684869

684845
type: SpeciesReference
stoichiometry: 1.0
species: 625747

625747
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: Succinate_m

684857
type: SpeciesReference
stoichiometry: 1.0
species: 624811

684881
type: SpeciesReference
stoichiometry: 1.0
species: 624763

624763
type: Species
has only substance units: false
name: Pi_m
is: http://identifiers.org/cas/7664-38-2
is: http://identifiers.org/pubchem.compound/3311
is: C00009
constant: false
is: CHEBI:18367
boundary condition: false
initial concentration: 0.0105
initial amount: NaN
in compartment: 623863

684893
type: SpeciesReference
stoichiometry: 1.0
species: 626875

684833
type: SpeciesReference
stoichiometry: 1.0
species: 624367

624367
type: Species
is: http://identifiers.org/pubchem.compound/3304
boundary condition: false
is: CHEBI:15422
initial concentration: 3.38E-4
is: http://identifiers.org/cas/56-65-5
has only substance units: false
name: ATP_m
initial amount: NaN
is: C00002
constant: false
in compartment: 623863

684869
type: SpeciesReference
stoichiometry: 1.0
species: 624691

624691
type: Species
is: http://identifiers.org/cas/20398-34-9
has only substance units: false
is: C00008
initial amount: NaN
is: CHEBI:16761
is: http://identifiers.org/pubchem.compound/3310
in compartment: 623863
initial concentration: 1.32E-4
boundary condition: false
name: ADP_m
constant: false

749400
type: Reaction
product: 749436
reactant: 749412
fast: false
reversible: false
reactant: 749424
is: ENSMUSG00000026600
product: 749448
is: ENSMUSG00000023045
name: r1167
notes: EC:2.3.1.26

749436
type: SpeciesReference
stoichiometry: 1.0
species: 624787

749412
type: SpeciesReference
stoichiometry: 1.0
species: 631326

631326
type: Species
initial concentration: 2.6E-4
name: Oleoyl-CoA_r
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3793
constant: false
in compartment: 623923
boundary condition: false
is: C00510
is: CHEBI:15534

749424
type: SpeciesReference
stoichiometry: 1.0
species: 628639

749448
type: SpeciesReference
stoichiometry: 1.0
species: 637843

637843
type: Species
name: Cholesterol-ester-ol_r
has only substance units: false
is: http://identifiers.org/pubchem.compound/4266381
constant: false
is: CHEBI:46898
initial amount: NaN
in compartment: 623923
boundary condition: false
initial concentration: 2.6E-4

713297
type: Reaction
reactant: 713309
product: 713321
is: ENSMUSG00000033429
reversible: true
name: r0572
fast: false
is: R02765
notes: (R)-2-Methyl-3-oxopropanoyl-CoA 2-epimerase Valine, leucine and isoleucine degradation / Propanoate metabolism EC:5.1.99.1
is: K05606

713309
type: SpeciesReference
stoichiometry: 1.0
species: 633007

713321
type: SpeciesReference
stoichiometry: 1.0
species: 631950

631950
type: Species
initial concentration: 2.6E-4
has only substance units: false
boundary condition: false
is: CHEBI:15466
initial amount: NaN
in compartment: 623863
constant: false
name: Methylmalonyl-CoA_m
is: http://identifiers.org/pubchem.compound/3952
is: C00683

651530
type: Constraint
message: Warning: Species concentration Threonine_l is out of the soft bounds.

642678
type: Constraint
message: Warning: Species concentration ATP_r is out of the soft bounds.

661789
type: Constraint
message: Error: Species concentration O-Acetylcarnitine_c is out of the hard bounds.

671664
type: Constraint
message: Warning: Species concentration Dihomo-gamma-linolenate_r is out of the soft bounds.

659353
type: Constraint
message: Warning: Species concentration Protoporphyrinogen_IX_m is out of the soft bounds.

672444
type: Constraint
message: Error: Species concentration Glycogenin-G4G7_c is out of the hard bounds.

655586
type: Constraint
message: Warning: Species concentration Histamine_c is out of the soft bounds.

644417
type: Constraint
message: Error: Species concentration Pyruvate_c is out of the hard bounds.

746156
type: Reaction
reactant: 746181
product: 746459
notes: Apo-AI Protein assembly
reactant: 746399
fast: false
reactant: 746375
reactant: 746267
reactant: 746243
product: 746447
product: 746411
reactant: 746387
reactant: 746363
reactant: 746327
is: ENSMUSG00000032083
reactant: 746315
reactant: 746255
reactant: 746231
name: r1113
reactant: 746207
reactant: 746169
reactant: 746291
reactant: 746339
product: 746435
reactant: 746219
reactant: 746351
reactant: 746194
reactant: 746279
reversible: false
reactant: 746303
product: 746423

746181
type: SpeciesReference
stoichiometry: 17.0
species: 626155

746459
type: SpeciesReference
stoichiometry: 801.0
species: 624727

746399
type: SpeciesReference
stoichiometry: 22.0
species: 625819

746375
type: SpeciesReference
stoichiometry: 5.0
species: 628147

746267
type: SpeciesReference
stoichiometry: 8.0
species: 626575

746243
type: SpeciesReference
stoichiometry: 41.0
species: 627559

746447
type: SpeciesReference
stoichiometry: 801.0
species: 624655

746411
type: SpeciesReference
stoichiometry: 1.0
species: 624067

746387
type: SpeciesReference
stoichiometry: 16.0
species: 625867

746363
type: SpeciesReference
stoichiometry: 1068.0
species: 624259

746327
type: SpeciesReference
stoichiometry: 7.0
species: 626695

746315
type: SpeciesReference
stoichiometry: 5.0
species: 626539

746255
type: SpeciesReference
stoichiometry: 4.0
species: 626407

746231
type: SpeciesReference
stoichiometry: 6.0
species: 627835

746207
type: SpeciesReference
stoichiometry: 30.0
species: 625291

746169
type: SpeciesReference
stoichiometry: 23.0
species: 625675

746291
type: SpeciesReference
stoichiometry: 16.0
species: 626299

746339
type: SpeciesReference
stoichiometry: 15.0
species: 628531

746435
type: SpeciesReference
stoichiometry: 267.0
species: 624919

746219
type: SpeciesReference
stoichiometry: 11.0
species: 625627

746351
type: SpeciesReference
stoichiometry: 1068.0
species: 624331

746194
type: SpeciesReference
stoichiometry: 19.0
species: 626251

746279
type: SpeciesReference
stoichiometry: 10.0
species: 628075

746303
type: SpeciesReference
stoichiometry: 12.0
species: 628699

746423
type: SpeciesReference
stoichiometry: 267.0
species: 625135

695897
type: Reaction
notes: N-Acyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.8
fast: false
reversible: true
product: 695921
name: r0291
is: ENSMUSG00000031387
is: K01787
is: R01207
reactant: 695909

695921
type: SpeciesReference
stoichiometry: 1.0
species: 631842

631842
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: CHEBI:17122
name: N-Acetyl-D-mannosamine_c
in compartment: 623911
has only substance units: false
is: C00645
is: http://identifiers.org/cas/3615-17-6
is: http://identifiers.org/pubchem.compound/3918
initial concentration: 2.6E-4

695909
type: SpeciesReference
stoichiometry: 1.0
species: 627955

627955
type: Species
initial concentration: 2.6E-4
in compartment: 623911
constant: false
is: C00140
has only substance units: false
is: http://identifiers.org/cas/7512-17-6
is: CHEBI:17411
boundary condition: false
is: http://identifiers.org/pubchem.compound/3440
name: N-Acetylglucosamine_c
initial amount: NaN

652550
type: Constraint
message: Error: Species concentration dCMP_c is out of the hard bounds.

647095
type: Constraint
message: Error: Species concentration Ornithine_s is out of the hard bounds.

638646
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Phosphatidate-Bile-PC-pool_c

781722
type: Reaction
is: ENSMUSG00000040010
product: 781758
reactant: 781746
name: r1569
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: 781770
fast: false
reactant: 781734

781758
type: SpeciesReference
stoichiometry: 1.0
species: 625675

781746
type: SpeciesReference
stoichiometry: 1.0
species: 628699

781770
type: SpeciesReference
stoichiometry: 1.0
species: 628711

781734
type: SpeciesReference
stoichiometry: 1.0
species: 625687

652826
type: Constraint
message: Warning: Species concentration Palmitate_c is out of the soft bounds.

807554
type: Reaction
name: r1905
reversible: false
product: 807626
notes: Y+LAT2 Utilized transport
fast: false
product: 807602
product: 807614
reactant: 807590
is: ENSMUSG00000031904
reactant: 807566
reactant: 807578

807626
type: SpeciesReference
stoichiometry: 1.0
species: 633079

807602
type: SpeciesReference
stoichiometry: 1.0
species: 630798

807614
type: SpeciesReference
stoichiometry: 1.0
species: 627019

807590
type: SpeciesReference
stoichiometry: 1.0
species: 633091

807566
type: SpeciesReference
stoichiometry: 1.0
species: 630810

807578
type: SpeciesReference
stoichiometry: 1.0
species: 627007

636439
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
is: C05763
initial amount: NaN
name: (2E)-Hexadecenoyl-ACP_c
in compartment: 623911
is: http://identifiers.org/pubchem.compound/8058

676055
type: Constraint
message: Warning: Species concentration Collagen_CO2A1_c is out of the soft bounds.

671148
type: Constraint
message: Error: Species concentration CDP-diacylglycerol-VLDL-PI-pool_r is out of the hard bounds.

667248
type: Constraint
message: Warning: Species concentration L-erythro-4-Hydroxyglutamate_m is out of the soft bounds.

661909
type: Constraint
message: Error: Species concentration 3-Ureidopropionate_c is out of the hard bounds.

669336
type: Constraint
message: Warning: Species concentration SM-pool_r is out of the soft bounds.

672840
type: Constraint
message: Warning: Species concentration LacCer-pool_s is out of the soft bounds.

798340
type: Reaction
is: ENSMUSG00000031904
reversible: false
notes: Y+LAT2 Utilized transport
product: 798412
product: 798400
fast: false
reactant: 798376
product: 798388
reactant: 798364
reactant: 798352
name: r1796

798412
type: SpeciesReference
stoichiometry: 1.0
species: 633079

798400
type: SpeciesReference
stoichiometry: 1.0
species: 626419

798376
type: SpeciesReference
stoichiometry: 1.0
species: 633091

798388
type: SpeciesReference
stoichiometry: 1.0
species: 627007

798364
type: SpeciesReference
stoichiometry: 1.0
species: 626407

798352
type: SpeciesReference
stoichiometry: 1.0
species: 627019

625507
type: Species
constant: false
has only substance units: false
in compartment: 623911
initial concentration: 2.6E-4
is: C00032
is: http://identifiers.org/pubchem.compound/3334
initial amount: NaN
is: CHEBI:17627
is: http://identifiers.org/cas/14875-96-8
boundary condition: true
name: Heme_c

629827
type: Species
is: C00300
has only substance units: false
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/cas/57-00-1
name: Creatine_c
boundary condition: false
initial concentration: 2.6E-4
is: CHEBI:16919
is: http://identifiers.org/pubchem.compound/3594
constant: false

760126
type: Reaction
product: 760162
product: 760150
reactant: 760138
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r1331

760162
type: SpeciesReference
stoichiometry: 1.0
species: 639030

639030
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623911
name: Proton-gradient_c

760150
type: SpeciesReference
stoichiometry: 1.0
species: 626623

760138
type: SpeciesReference
stoichiometry: 1.0
species: 626635

635071
type: Species
constant: false
boundary condition: false
is: C05119
name: S-(3-Methylbutanoyl)-dihydrolipoamide_m
is: CHEBI:27462
is: http://identifiers.org/pubchem.compound/7543
initial concentration: 2.6E-4
has only substance units: false
in compartment: 623863
initial amount: NaN

721545
type: Reaction
fast: false
reversible: false
reactant: 721558
is: ENSMUSG00000027710
product: 721597
notes: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
is: R04592
is: K00257
name: r0706
product: 721584
reactant: 721571

721558
type: SpeciesReference
stoichiometry: 1.0
species: 624631

721597
type: SpeciesReference
stoichiometry: 1.0
species: 625423

721584
type: SpeciesReference
stoichiometry: 1.0
species: 635899

635899
type: Species
is: http://identifiers.org/pubchem.compound/7820
boundary condition: false
is: C05460
in compartment: 623899
initial amount: NaN
constant: false
initial concentration: 2.6E-4
is: CHEBI:27505
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA_p
has only substance units: false

721571
type: SpeciesReference
stoichiometry: 1.0
species: 634963

634963
type: Species
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoyl-CoA_p
constant: false
initial amount: NaN
in compartment: 623899
is: http://identifiers.org/pubchem.compound/7328
is: CHEBI:15493
has only substance units: false
initial concentration: 2.6E-4
is: C04760
boundary condition: false

664177
type: Constraint
message: Warning: Species concentration 14-Demethyllanosterol_r is out of the soft bounds.

633847
type: Species
name: O-Acetylcarnitine_r
boundary condition: false
is: C02571
has only substance units: false
initial amount: NaN
in compartment: 623923
is: http://identifiers.org/pubchem.compound/5567
is: CHEBI:15960
initial concentration: 2.6E-4
constant: false

641034
type: Species
is: Q01955
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CO4A3_c

845903
type: Reaction
reactant: 845915
reversible: false
product: 845939
name: r2432
is: ENSMUSG00000020744
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.16.1
fast: false
reactant: 845927
product: 845951

845915
type: SpeciesReference
stoichiometry: 1.0
species: 631134

631134
type: Species
initial concentration: 2.6E-4
constant: false
is: C00460
name: dUTP_c
initial amount: NaN
is: CHEBI:17625
in compartment: 623911
has only substance units: false
is: http://identifiers.org/pubchem.compound/3744
boundary condition: false

845939
type: SpeciesReference
stoichiometry: 1.0
species: 631146

631146
type: Species
boundary condition: false
name: dUTP_m
constant: false
has only substance units: false
is: C00460
is: http://identifiers.org/pubchem.compound/3744
in compartment: 623863
is: CHEBI:17625
initial concentration: 2.6E-4
initial amount: NaN

845927
type: SpeciesReference
stoichiometry: 1.0
species: 624691

845951
type: SpeciesReference
stoichiometry: 1.0
species: 624655

776335
type: Reaction
product: 776359
reactant: 776347
notes: Utilized transport
fast: false
reversible: false
name: r1492

776359
type: SpeciesReference
stoichiometry: 1.0
species: 629227

629227
type: Species
is: CHEBI:29103
has only substance units: false
constant: false
is: http://identifiers.org/cas/7440-09-7
boundary condition: true
initial concentration: 0.022
in compartment: 623935
is: C00238
name: K+_s
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3537

776347
type: SpeciesReference
stoichiometry: 1.0
species: 629215

629215
type: Species
is: CHEBI:29103
has only substance units: false
in compartment: 623911
initial concentration: 2.6E-4
boundary condition: false
is: C00238
constant: false
is: http://identifiers.org/cas/7440-09-7
is: http://identifiers.org/pubchem.compound/3537
initial amount: NaN
name: K+_c

651002
type: Constraint
message: Warning: Species concentration Carbamoyl-P_m is out of the soft bounds.

671544
type: Constraint
message: Warning: Species concentration PGP-CL-pool_m is out of the soft bounds.

671280
type: Constraint
message: Warning: Species concentration Bile-PC-pool_c is out of the soft bounds.

648914
type: Constraint
message: Warning: Species concentration Glycerol_c is out of the soft bounds.

645137
type: Constraint
message: Error: Species concentration Acetate_m is out of the hard bounds.

831167
type: Reaction
name: r2229
product: 831215
is: ENSMUSG00000030236
reactant: 831191
reactant: 831203
product: 831238
reactant: 831179
product: 831227
reversible: true
fast: false
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

831215
type: SpeciesReference
stoichiometry: 1.0
species: 634759

831191
type: SpeciesReference
stoichiometry: 1.0
species: 629719

831203
type: SpeciesReference
stoichiometry: 1.0
species: 639990

831238
type: SpeciesReference
stoichiometry: 1.0
species: 640002

831179
type: SpeciesReference
stoichiometry: 1.0
species: 634771

831227
type: SpeciesReference
stoichiometry: 1.0
species: 629731

777174
type: Reaction
reactant: 777210
reactant: 777198
is: ENSMUSG00000027048
fast: false
reactant: 777186
product: 777246
product: 777222
name: r1506
product: 777234
reversible: false
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.201.2

777210
type: SpeciesReference
stoichiometry: 1.0
species: 624259

777198
type: SpeciesReference
stoichiometry: 1.0
species: 624331

777186
type: SpeciesReference
stoichiometry: 1.0
species: 635923

635923
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/7825
name: Taurochenodeoxycholate_c
in compartment: 623911
initial amount: NaN
constant: false
initial concentration: 2.6E-4
is: CHEBI:16525
is: http://identifiers.org/cas/516-35-8
is: C05465
has only substance units: false

777246
type: SpeciesReference
stoichiometry: 1.0
species: 624727

777222
type: SpeciesReference
stoichiometry: 1.0
species: 635911

635911
type: Species
is: CHEBI:16525
is: http://identifiers.org/pubchem.compound/7825
is: http://identifiers.org/cas/516-35-8
has only substance units: false
initial concentration: 2.6E-4
in compartment: 623887
name: Taurochenodeoxycholate_b
constant: false
is: C05465
boundary condition: true
initial amount: NaN

777234
type: SpeciesReference
stoichiometry: 1.0
species: 624655

704418
type: Reaction
is: K08766
is: ENSMUSG00000028607
fast: false
reactant: 704430
reversible: true
is: R01923
product: 704454
reactant: 704442
is: K08765
product: 704466
name: r0430
is: ENSMUSG00000024900
notes: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21

704430
type: SpeciesReference
stoichiometry: 1.0
species: 626743

704454
type: SpeciesReference
stoichiometry: 1.0
species: 624787

704442
type: SpeciesReference
stoichiometry: 1.0
species: 629971

704466
type: SpeciesReference
stoichiometry: 1.0
species: 640746

640746
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: Malonyl-Carnitin_r

825119
type: Reaction
is: ENSMUSG00000030237
reactant: 825143
product: 825191
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
product: 825167
name: r2157
is: ENSMUSG00000063975
reactant: 825155
is: ENSMUSG00000079262
is: ENSMUSG00000041698
fast: false
product: 825179
reactant: 825131

825143
type: SpeciesReference
stoichiometry: 1.0
species: 629719

825191
type: SpeciesReference
stoichiometry: 1.0
species: 639930

825167
type: SpeciesReference
stoichiometry: 1.0
species: 633799

633799
type: Species
is: http://identifiers.org/cas/474-25-9
boundary condition: false
constant: false
in compartment: 623911
is: C02528
has only substance units: false
is: CHEBI:16755
name: Chenodiol_c
is: http://identifiers.org/pubchem.compound/5536
initial amount: NaN
initial concentration: 2.6E-4

825155
type: SpeciesReference
stoichiometry: 1.0
species: 639918

825179
type: SpeciesReference
stoichiometry: 1.0
species: 629731

825131
type: SpeciesReference
stoichiometry: 1.0
species: 633811

633811
type: Species
has only substance units: false
constant: false
is: CHEBI:16755
initial concentration: 2.6E-4
in compartment: 623935
boundary condition: true
is: C02528
is: http://identifiers.org/pubchem.compound/5536
initial amount: NaN
name: Chenodiol_s
is: http://identifiers.org/cas/474-25-9

636715
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 2.6E-4
is: CHEBI:28391
constant: false
is: C06157
is: http://identifiers.org/pubchem.compound/8413
name: S-Glutaryldihydrolipoamide_m
in compartment: 623863

644537
type: Constraint
message: Error: Species concentration Acetyl-CoA_c is out of the hard bounds.

645281
type: Constraint
message: Error: Species concentration Glycine_c is out of the hard bounds.

647004
type: Constraint
message: Warning: Species concentration PEP_m is out of the soft bounds.

736326
type: Reaction
reversible: false
reactant: 736338
notes: COT Facilitated diffusion
reactant: 736350
fast: false
name: r0997
product: 736362
is: ENSMUSG00000003623
product: 736374

736338
type: SpeciesReference
stoichiometry: 1.0
species: 633967

633967
type: Species
is: http://identifiers.org/pubchem.compound/5780
initial concentration: 2.6E-4
constant: false
has only substance units: false
name: L-Octanoylcarnitine_p
is: C02838
is: CHEBI:18102
in compartment: 623899
initial amount: NaN
boundary condition: false

736350
type: SpeciesReference
stoichiometry: 1.0
species: 629983

736362
type: SpeciesReference
stoichiometry: 1.0
species: 633943

633943
type: Species
in compartment: 623911
has only substance units: false
is: CHEBI:18102
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 2.6E-4
name: L-Octanoylcarnitine_c
is: http://identifiers.org/pubchem.compound/5780
is: C02838

736374
type: SpeciesReference
stoichiometry: 1.0
species: 630007

630007
type: Species
name: L-Carnitine_p
constant: false
is: CHEBI:16347
in compartment: 623899
is: http://identifiers.org/cas/541-15-1
initial concentration: 2.6E-4
is: C00318
is: http://identifiers.org/pubchem.compound/3612
boundary condition: false
has only substance units: false
initial amount: NaN

650918
type: Constraint
message: Error: Species concentration UDP-glucuronate_c is out of the hard bounds.

872897
type: Reaction
product: 873125
fast: false
reversible: false
product: 873029
reactant: 872933
product: 873089
product: 873173
product: 872981
reactant: 872921
product: 873137
product: 873101
reactant: 872909
product: 873185
product: 873005
product: 872993
product: 873149
product: 872969
product: 873065
product: 873017
product: 873077
product: 873161
notes: Protein degradation
name: r2603
product: 872945
product: 873041
product: 873113
product: 872957
product: 873053
product: 873197

873125
type: SpeciesReference
stoichiometry: 65.0
species: 626299

873029
type: SpeciesReference
stoichiometry: 30.0
species: 630798

872933
type: SpeciesReference
stoichiometry: 868.0
species: 624259

873089
type: SpeciesReference
stoichiometry: 299.0
species: 628075

873173
type: SpeciesReference
stoichiometry: 23.0
species: 626695

872981
type: SpeciesReference
stoichiometry: 110.0
species: 625291

872921
type: SpeciesReference
stoichiometry: 868.0
species: 624331

873137
type: SpeciesReference
stoichiometry: 60.0
species: 628699

873101
type: SpeciesReference
stoichiometry: 87.0
species: 626251

872909
type: SpeciesReference
stoichiometry: 1.0
species: 641274

641274
type: Species
is: P13942
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_COBA2_c

873185
type: SpeciesReference
stoichiometry: 868.0
species: 624655

873005
type: SpeciesReference
stoichiometry: 428.0
species: 625627

872993
type: SpeciesReference
stoichiometry: 31.0
species: 626575

873149
type: SpeciesReference
stoichiometry: 74.0
species: 628531

872969
type: SpeciesReference
stoichiometry: 79.0
species: 625867

873065
type: SpeciesReference
stoichiometry: 16.0
species: 626407

873017
type: SpeciesReference
stoichiometry: 20.0
species: 627835

873077
type: SpeciesReference
stoichiometry: 15.0
species: 628147

873161
type: SpeciesReference
stoichiometry: 3.0
species: 626539

872945
type: SpeciesReference
stoichiometry: 98.0
species: 625675

873041
type: SpeciesReference
stoichiometry: 72.0
species: 625819

873113
type: SpeciesReference
stoichiometry: 101.0
species: 626155

872957
type: SpeciesReference
stoichiometry: 14.0
species: 627007

873053
type: SpeciesReference
stoichiometry: 111.0
species: 627559

873197
type: SpeciesReference
stoichiometry: 868.0
species: 624727

852432
type: Reaction
product: 852770
reactant: 852575
is: ENSMUSG00000022878
reactant: 852718
reactant: 852692
reactant: 852627
product: 852744
reactant: 852640
reactant: 852666
reactant: 852562
reactant: 852536
product: 852757
reactant: 852484
reactant: 852588
name: r2540
reactant: 852549
reactant: 852510
reactant: 852497
fast: false
reactant: 852601
product: 852783
reactant: 852471
reactant: 852445
reactant: 852614
reactant: 852653
reactant: 852679
notes: apM-1 Protein assembly
reactant: 852523
reversible: false
reactant: 852458
product: 852731
reactant: 852705

852770
type: SpeciesReference
stoichiometry: 244.0
species: 625135

852575
type: SpeciesReference
stoichiometry: 5.0
species: 626407

852718
type: SpeciesReference
stoichiometry: 976.0
species: 624259

852692
type: SpeciesReference
stoichiometry: 14.0
species: 626695

852627
type: SpeciesReference
stoichiometry: 7.0
species: 626155

852744
type: SpeciesReference
stoichiometry: 732.0
species: 624655

852640
type: SpeciesReference
stoichiometry: 7.0
species: 626299

852666
type: SpeciesReference
stoichiometry: 14.0
species: 628531

852562
type: SpeciesReference
stoichiometry: 23.0
species: 627559

852536
type: SpeciesReference
stoichiometry: 9.0
species: 630798

852757
type: SpeciesReference
stoichiometry: 732.0
species: 624727

852484
type: SpeciesReference
stoichiometry: 12.0
species: 625291

852588
type: SpeciesReference
stoichiometry: 11.0
species: 628147

852549
type: SpeciesReference
stoichiometry: 12.0
species: 625819

852510
type: SpeciesReference
stoichiometry: 39.0
species: 625627

852497
type: SpeciesReference
stoichiometry: 10.0
species: 626575

852601
type: SpeciesReference
stoichiometry: 17.0
species: 628075

852783
type: SpeciesReference
stoichiometry: 244.0
species: 624919

852471
type: SpeciesReference
stoichiometry: 15.0
species: 625867

852445
type: SpeciesReference
stoichiometry: 12.0
species: 625675

852614
type: SpeciesReference
stoichiometry: 10.0
species: 626251

852653
type: SpeciesReference
stoichiometry: 15.0
species: 628699

852679
type: SpeciesReference
stoichiometry: 2.0
species: 626539

852523
type: SpeciesReference
stoichiometry: 8.0
species: 627835

852458
type: SpeciesReference
stoichiometry: 2.0
species: 627007

852731
type: SpeciesReference
stoichiometry: 1.0
species: 640902

640902
type: Species
is: Q15848
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_ADIPO_c

852705
type: SpeciesReference
stoichiometry: 976.0
species: 624331

646313
type: Constraint
message: Error: Species concentration FMN_c is out of the hard bounds.

875801
type: Reaction
reactant: 876065
product: 876113
reactant: 876017
reactant: 875861
product: 876101
product: 876089
reversible: false
name: r2612
is: ENSMUSG00000040690
reactant: 876041
reactant: 875873
reactant: 875933
reactant: 875909
product: 876077
reactant: 875897
reactant: 875849
reactant: 875837
reactant: 875813
reactant: 875957
reactant: 875993
notes: Collagen alpha-1(XVI) chain Protein assembly
reactant: 876029
product: 876125
reactant: 875969
reactant: 875945
reactant: 875981
reactant: 876053
reactant: 875921
reactant: 875885
reactant: 876005
fast: false
reactant: 875825

876065
type: SpeciesReference
stoichiometry: 6416.0
species: 624259

876113
type: SpeciesReference
stoichiometry: 1604.0
species: 625135

876017
type: SpeciesReference
stoichiometry: 63.0
species: 628531

875861
type: SpeciesReference
stoichiometry: 30.0
species: 626575

876101
type: SpeciesReference
stoichiometry: 4812.0
species: 624727

876089
type: SpeciesReference
stoichiometry: 4812.0
species: 624655

876041
type: SpeciesReference
stoichiometry: 13.0
species: 626695

875873
type: SpeciesReference
stoichiometry: 391.0
species: 625627

875933
type: SpeciesReference
stoichiometry: 26.0
species: 626407

875909
type: SpeciesReference
stoichiometry: 87.0
species: 625819

876077
type: SpeciesReference
stoichiometry: 1.0
species: 641334

641334
type: Species
is: Q07092
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_COGA1_c

875897
type: SpeciesReference
stoichiometry: 41.0
species: 630798

875849
type: SpeciesReference
stoichiometry: 92.0
species: 625291

875837
type: SpeciesReference
stoichiometry: 52.0
species: 625867

875813
type: SpeciesReference
stoichiometry: 85.0
species: 625675

875957
type: SpeciesReference
stoichiometry: 282.0
species: 628075

875993
type: SpeciesReference
stoichiometry: 76.0
species: 626299

876029
type: SpeciesReference
stoichiometry: 8.0
species: 626539

876125
type: SpeciesReference
stoichiometry: 1604.0
species: 624919

875969
type: SpeciesReference
stoichiometry: 79.0
species: 626251

875945
type: SpeciesReference
stoichiometry: 23.0
species: 628147

875981
type: SpeciesReference
stoichiometry: 63.0
species: 626155

876053
type: SpeciesReference
stoichiometry: 6416.0
species: 624331

875921
type: SpeciesReference
stoichiometry: 99.0
species: 627559

875885
type: SpeciesReference
stoichiometry: 19.0
species: 627835

876005
type: SpeciesReference
stoichiometry: 43.0
species: 628699

875825
type: SpeciesReference
stoichiometry: 32.0
species: 627007

661225
type: Constraint
message: Warning: Species concentration Acetylcholine_b is out of the soft bounds.

655010
type: Constraint
message: Warning: Species concentration dGMP_s is out of the soft bounds.

632851
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: Provitamin_D3_r

736806
type: Reaction
product: 736854
product: 736842
reactant: 736830
reactant: 736818
notes: Facilitated diffusion
fast: false
reversible: true
name: r1005

736854
type: SpeciesReference
stoichiometry: 1.0
species: 640758

640758
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Malonyl-Carnitin_c

736842
type: SpeciesReference
stoichiometry: 1.0
species: 629995

736830
type: SpeciesReference
stoichiometry: 1.0
species: 640770

640770
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: Malonyl-Carnitin_m

736818
type: SpeciesReference
stoichiometry: 1.0
species: 629983

770324
type: Reaction
reactant: 770348
product: 770360
is: ENSMUSG00000026853
name: r1395
reversible: true
product: 770372
notes: carnitine acetyltransferase EC:2.3.1.7
reactant: 770336
fast: false

770348
type: SpeciesReference
stoichiometry: 1.0
species: 629995

770360
type: SpeciesReference
stoichiometry: 1.0
species: 624811

770372
type: SpeciesReference
stoichiometry: 1.0
species: 639246

639246
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: L-Oleoylcarnitine_m

770336
type: SpeciesReference
stoichiometry: 1.0
species: 631350

631350
type: Species
initial concentration: 2.6E-4
is: C00510
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3793
is: CHEBI:15534
name: Oleoyl-CoA_m
has only substance units: false
initial amount: NaN
in compartment: 623863

635047
type: Species
is: CHEBI:18364
constant: false
is: http://identifiers.org/cas/7448-02-4
name: 14-Demethyllanosterol_r
is: http://identifiers.org/pubchem.compound/7534
boundary condition: false
is: C05108
in compartment: 623923
initial amount: NaN
initial concentration: 2.6E-4
has only substance units: false

636283
type: Species
is: http://identifiers.org/pubchem.compound/8045
constant: false
initial amount: NaN
boundary condition: false
name: 3-Oxooctanoyl-ACP_c
initial concentration: 2.6E-4
is: C05750
has only substance units: false
in compartment: 623911

851350
type: Reaction
reactant: 851374
fast: false
name: r2516
reactant: 851362
product: 851398
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: ENSMUSG00000032902
product: 851386

851374
type: SpeciesReference
stoichiometry: 1.0
species: 628627

628627
type: Species
constant: false
initial concentration: 2.6E-4
initial amount: NaN
is: C00186
boundary condition: false
is: http://identifiers.org/cas/79-33-4
name: L-Lactate_p
has only substance units: false
is: CHEBI:422
in compartment: 623899
is: http://identifiers.org/pubchem.compound/3486

851362
type: SpeciesReference
stoichiometry: 1.0
species: 626659

626659
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-7
initial amount: NaN
in compartment: 623899
name: H+(PG)_p

851398
type: SpeciesReference
stoichiometry: 1.0
species: 628591

851386
type: SpeciesReference
stoichiometry: 1.0
species: 626623

785826
type: Reaction
fast: false
name: r1637
is: ENSMUSG00000040010
product: 785874
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: 785838
product: 785862
reversible: true
reactant: 785850

785874
type: SpeciesReference
stoichiometry: 1.0
species: 628159

785838
type: SpeciesReference
stoichiometry: 1.0
species: 627019

785862
type: SpeciesReference
stoichiometry: 1.0
species: 627007

785850
type: SpeciesReference
stoichiometry: 1.0
species: 628147

657806
type: Constraint
message: Error: Species concentration Pyridoxamine-P_c is out of the hard bounds.

822180
type: Reaction
reactant: 822192
product: 822228
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: 822216
reactant: 822204
fast: false
reversible: true
name: r2114
is: ENSMUSG00000032902

822192
type: SpeciesReference
stoichiometry: 1.0
species: 625543

625543
type: Species
in compartment: 623935
is: CHEBI:15366
is: http://identifiers.org/cas/64-19-7
initial concentration: 2.6E-4
has only substance units: false
is: http://identifiers.org/pubchem.compound/3335
is: C00033
name: Acetate_s
constant: false
boundary condition: true
initial amount: NaN

822228
type: SpeciesReference
stoichiometry: 1.0
species: 632155

822216
type: SpeciesReference
stoichiometry: 1.0
species: 625531

822204
type: SpeciesReference
stoichiometry: 1.0
species: 632143

693137
type: Reaction
is: ENSMUSG00000052131
is: ENSMUSG00000029762
name: r0245
product: 693185
is: K00011
product: 693173
reactant: 693161
reactant: 693149
is: R01041
reversible: true
notes: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
is: ENSMUSG00000001642
fast: false
is: K00002
is: ENSMUSG00000028692

693185
type: SpeciesReference
stoichiometry: 1.0
species: 624499

693173
type: SpeciesReference
stoichiometry: 1.0
species: 631638

693161
type: SpeciesReference
stoichiometry: 1.0
species: 624547

693149
type: SpeciesReference
stoichiometry: 1.0
species: 627415

627415
type: Species
name: Glycerol_c
initial concentration: 2.6E-4
is: CHEBI:17754
is: C00116
is: http://identifiers.org/pubchem.compound/3416
constant: false
in compartment: 623911
is: http://identifiers.org/cas/56-81-5
boundary condition: false
initial amount: NaN
has only substance units: false

660169
type: Constraint
message: Warning: Species concentration Glucono-1,5-lactone-6P_c is out of the soft bounds.

748727
type: Reaction
reversible: true
reactant: 748751
notes: dUTP:uridine 5'-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
product: 748775
is: R02332
fast: false
name: r1156
is: ENSMUSG00000002550
is: K00876
product: 748763
is: ENSMUSG00000026558
reactant: 748739

748751
type: SpeciesReference
stoichiometry: 1.0
species: 631134

748775
type: SpeciesReference
stoichiometry: 1.0
species: 627211

627211
type: Species
in compartment: 623911
constant: false
is: http://identifiers.org/cas/58-97-9
boundary condition: false
initial amount: NaN
initial concentration: 2.6E-4
is: CHEBI:16695
is: C00105
is: http://identifiers.org/pubchem.compound/3405
has only substance units: false
name: UMP_c

748763
type: SpeciesReference
stoichiometry: 1.0
species: 633127

633127
type: Species
is: CHEBI:28850
boundary condition: false
name: dUDP_c
is: http://identifiers.org/pubchem.compound/4551
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 2.6E-4
is: C01346
in compartment: 623911

748739
type: SpeciesReference
stoichiometry: 1.0
species: 629803

629803
type: Species
is: http://identifiers.org/pubchem.compound/3593
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: http://identifiers.org/cas/58-96-8
is: CHEBI:16704
initial concentration: 2.6E-4
in compartment: 623911
is: C00299
name: Uridine_c

651182
type: Constraint
message: Error: Species concentration Valine_l is out of the hard bounds.

840132
type: Reaction
is: ENSMUSG00000032548
product: 840192
reversible: true
reactant: 840156
reactant: 840168
reactant: 840144
fast: false
product: 840180
name: r2335
product: 840204
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

840192
type: SpeciesReference
stoichiometry: 1.0
species: 629731

840156
type: SpeciesReference
stoichiometry: 1.0
species: 629719

840168
type: SpeciesReference
stoichiometry: 1.0
species: 625915

840144
type: SpeciesReference
stoichiometry: 1.0
species: 640434

840180
type: SpeciesReference
stoichiometry: 1.0
species: 640422

640422
type: Species
is: http://identifiers.org/pubchem.compound/4527
is: CHEBI:15552
boundary condition: false
initial amount: NaN
constant: false
is: C01312
name: prostaglandin-i2_c
has only substance units: false
initial concentration: 2.6E-4
in compartment: 623911
is: http://identifiers.org/cas/35121-78-9

840204
type: SpeciesReference
stoichiometry: 1.0
species: 625927

664021
type: Constraint
message: Error: Species concentration SAICAR_c is out of the hard bounds.

658861
type: Constraint
message: Error: Species concentration Dihydrothymine_m is out of the hard bounds.

824531
type: Reaction
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is: ENSMUSG00000079262
fast: false
name: r2150
is: ENSMUSG00000030237
product: 824579
product: 824603
product: 824591
is: ENSMUSG00000041698
reactant: 824543
reactant: 824567
is: ENSMUSG00000063975
reactant: 824555

824579
type: SpeciesReference
stoichiometry: 1.0
species: 639882

639882
type: Species
is: CHEBI:17864
is: C03642
constant: false
name: sulfotaurolithocholate_c
is: http://identifiers.org/cas/15324-65-9
boundary condition: false
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6424
initial concentration: 2.6E-4
has only substance units: false

824603
type: SpeciesReference
stoichiometry: 1.0
species: 625927

824591
type: SpeciesReference
stoichiometry: 1.0
species: 629731

824543
type: SpeciesReference
stoichiometry: 1.0
species: 639894

639894
type: Species
initial amount: NaN
initial concentration: 2.6E-4
boundary condition: false
in compartment: 623935
name: sulfotaurolithocholate_s
is: CHEBI:17864
is: C03642
has only substance units: false
constant: false
is: http://identifiers.org/cas/15324-65-9
is: http://identifiers.org/pubchem.compound/6424

824567
type: SpeciesReference
stoichiometry: 1.0
species: 625915

824555
type: SpeciesReference
stoichiometry: 1.0
species: 629719

703830
type: Reaction
fast: false
reactant: 703842
is: K00542
is: R01883
product: 703878
is: ENSMUSG00000020150
product: 703866
reversible: true
notes: S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase Glycine, serine and threonine metabolism / Arginine and proline metabolism EC:2.1.1.2
reactant: 703854
name: r0420

703842
type: SpeciesReference
stoichiometry: 1.0
species: 625111

625111
type: Species
is: http://identifiers.org/cas/29908-03-0
is: C00019
has only substance units: false
boundary condition: false
name: SAM_c
initial amount: NaN
is: CHEBI:15414
is: http://identifiers.org/pubchem.compound/3321
initial concentration: 2.6E-4
constant: false
in compartment: 623911

703878
type: SpeciesReference
stoichiometry: 1.0
species: 629827

703866
type: SpeciesReference
stoichiometry: 1.0
species: 625183

625183
type: Species
has only substance units: false
is: http://identifiers.org/cas/979-92-0
name: SAH_c
boundary condition: false
initial amount: NaN
in compartment: 623911
is: CHEBI:16680
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3323
is: C00021
constant: false

703854
type: SpeciesReference
stoichiometry: 1.0
species: 631674

631674
type: Species
is: CHEBI:16344
is: http://identifiers.org/cas/352-97-6
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3860
boundary condition: false
initial amount: NaN
is: C00581
has only substance units: false
in compartment: 623911
name: Guanidinoacetate_c
constant: false

651350
type: Constraint
message: Error: Species concentration Cholesterol_r is out of the hard bounds.

876137
type: Reaction
product: 876245
reactant: 876173
fast: false
product: 876341
product: 876281
product: 876197
product: 876257
product: 876353
product: 876293
product: 876269
product: 876365
notes: Protein degradation
reversible: false
name: r2613
product: 876377
product: 876209
product: 876401
product: 876305
product: 876389
product: 876437
product: 876413
product: 876317
product: 876221
product: 876425
product: 876329
reactant: 876161
reactant: 876149
product: 876233
product: 876185

876245
type: SpeciesReference
stoichiometry: 391.0
species: 625627

876173
type: SpeciesReference
stoichiometry: 802.0
species: 624259

876341
type: SpeciesReference
stoichiometry: 79.0
species: 626251

876281
type: SpeciesReference
stoichiometry: 87.0
species: 625819

876197
type: SpeciesReference
stoichiometry: 32.0
species: 627007

876257
type: SpeciesReference
stoichiometry: 19.0
species: 627835

876353
type: SpeciesReference
stoichiometry: 63.0
species: 626155

876293
type: SpeciesReference
stoichiometry: 99.0
species: 627559

876269
type: SpeciesReference
stoichiometry: 41.0
species: 630798

876365
type: SpeciesReference
stoichiometry: 76.0
species: 626299

876377
type: SpeciesReference
stoichiometry: 43.0
species: 628699

876209
type: SpeciesReference
stoichiometry: 52.0
species: 625867

876401
type: SpeciesReference
stoichiometry: 8.0
species: 626539

876305
type: SpeciesReference
stoichiometry: 26.0
species: 626407

876389
type: SpeciesReference
stoichiometry: 63.0
species: 628531

876437
type: SpeciesReference
stoichiometry: 802.0
species: 624727

876413
type: SpeciesReference
stoichiometry: 13.0
species: 626695

876317
type: SpeciesReference
stoichiometry: 23.0
species: 628147

876221
type: SpeciesReference
stoichiometry: 92.0
species: 625291

876425
type: SpeciesReference
stoichiometry: 802.0
species: 624655

876329
type: SpeciesReference
stoichiometry: 282.0
species: 628075

876161
type: SpeciesReference
stoichiometry: 802.0
species: 624331

876149
type: SpeciesReference
stoichiometry: 1.0
species: 641334

876233
type: SpeciesReference
stoichiometry: 30.0
species: 626575

876185
type: SpeciesReference
stoichiometry: 85.0
species: 625675

780342
type: Reaction
reversible: true
fast: false
reactant: 780354
product: 780390
name: r1546
reactant: 780366
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: ENSMUSG00000040010
product: 780378

780354
type: SpeciesReference
stoichiometry: 1.0
species: 625639

780390
type: SpeciesReference
stoichiometry: 1.0
species: 626419

780366
type: SpeciesReference
stoichiometry: 1.0
species: 626407

780378
type: SpeciesReference
stoichiometry: 1.0
species: 625627

772711
type: Reaction
product: 772735
reactant: 772723
notes: Free diffusion
fast: false
reversible: true
name: r1428

772735
type: SpeciesReference
stoichiometry: 1.0
species: 627319

627319
type: Species
is: CHEBI:16108
is: C00111
is: http://identifiers.org/pubchem.compound/3411
name: DHAP_p
in compartment: 623899
initial concentration: 0.002505
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false

772723
type: SpeciesReference
stoichiometry: 1.0
species: 627295

748103
type: Reaction
product: 748151
product: 748139
reactant: 748127
reactant: 748115
notes: Major Facilitator(MFS) TCDB:2.A.18.6.3
fast: false
reversible: true
name: r1144

748151
type: SpeciesReference
stoichiometry: 1.0
species: 633091

748139
type: SpeciesReference
stoichiometry: 1.0
species: 625303

748127
type: SpeciesReference
stoichiometry: 1.0
species: 633079

748115
type: SpeciesReference
stoichiometry: 1.0
species: 625291

645005
type: Constraint
message: Warning: Species concentration Glucose_c is out of the soft bounds.

631854
type: Species
is: http://identifiers.org/pubchem.compound/3918
name: N-Acetyl-D-mannosamine_s
has only substance units: false
is: http://identifiers.org/cas/3615-17-6
initial concentration: 2.6E-4
constant: false
initial amount: NaN
in compartment: 623935
is: CHEBI:17122
boundary condition: true
is: C00645

633439
type: Species
in compartment: 623923
name: Desmosterol_r
is: http://identifiers.org/pubchem.compound/4928
is: http://identifiers.org/cas/313-04-2
initial concentration: 2.6E-4
initial amount: NaN
is: C01802
constant: false
is: CHEBI:17737
has only substance units: false
boundary condition: false

728611
type: Reaction
product: 728659
reactant: 728635
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
name: r0830
reactant: 728623
product: 728647
is: ENSMUSG00000025792
fast: false
reversible: true

728659
type: SpeciesReference
stoichiometry: 1.0
species: 626947

626947
type: Species
initial amount: NaN
in compartment: 623911
is: C00094
boundary condition: true
is: http://identifiers.org/pubchem.compound/3394
is: CHEBI:48854
name: Sulfite_c
has only substance units: false
constant: false
initial concentration: 0.0026

728635
type: SpeciesReference
stoichiometry: 1.0
species: 626959

626959
type: Species
name: Sulfite_m
constant: false
initial amount: NaN
has only substance units: false
in compartment: 623863
boundary condition: false
initial concentration: 0.0026
is: C00094
is: http://identifiers.org/pubchem.compound/3394
is: CHEBI:48854

728623
type: SpeciesReference
stoichiometry: 1.0
species: 625723

625723
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Succinate_c

728647
type: SpeciesReference
stoichiometry: 1.0
species: 625747

777342
type: Reaction
reactant: 777366
product: 777402
fast: false
reactant: 777354
reactant: 777378
is: ENSMUSG00000042476
name: r1508
product: 777414
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.201.3
reversible: false
product: 777390

777366
type: SpeciesReference
stoichiometry: 1.0
species: 624331

777402
type: SpeciesReference
stoichiometry: 1.0
species: 624655

777354
type: SpeciesReference
stoichiometry: 1.0
species: 628663

628663
type: Species
name: Cholesterol_c
is: http://identifiers.org/pubchem.compound/3487
in compartment: 623911
is: CHEBI:16113
has only substance units: false
is: http://identifiers.org/cas/57-88-5
initial concentration: 1.0E-8
initial amount: NaN
boundary condition: false
constant: false
is: C00187

777378
type: SpeciesReference
stoichiometry: 1.0
species: 624259

777414
type: SpeciesReference
stoichiometry: 1.0
species: 624727

777390
type: SpeciesReference
stoichiometry: 1.0
species: 628651

629587
type: Species
name: N-Acetylneuraminate_c
constant: false
is: C00270
in compartment: 623911
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3568
is: CHEBI:17012
boundary condition: true
is: http://identifiers.org/cas/131-48-6
initial concentration: 2.6E-4

785448
type: Reaction
fast: false
reactant: 785474
product: 785500
product: 785487
is: ENSMUSG00000040010
name: r1631
reactant: 785461
reversible: true
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

785474
type: SpeciesReference
stoichiometry: 1.0
species: 628531

785500
type: SpeciesReference
stoichiometry: 1.0
species: 628543

785487
type: SpeciesReference
stoichiometry: 1.0
species: 626695

785461
type: SpeciesReference
stoichiometry: 1.0
species: 626707

626707
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: http://identifiers.org/cas/60-18-4
constant: false
is: C00082
is: http://identifiers.org/pubchem.compound/3382
is: CHEBI:17895
in compartment: 623935
name: Tyrosine_s
initial concentration: 2.6E-4

665173
type: Constraint
message: Error: Species concentration Chenodeoxycholoyl-CoA_c is out of the hard bounds.

665125
type: Constraint
message: Error: Species concentration (2E)-Octenoyl-CoA_m is out of the hard bounds.

729763
type: Reaction
product: 729787
reactant: 729775
notes: Free diffusion
fast: false
reversible: true
name: r0854

729787
type: SpeciesReference
stoichiometry: 1.0
species: 624595

729775
type: SpeciesReference
stoichiometry: 1.0
species: 624583

624583
type: Species
is: CHEBI:15379
initial amount: NaN
in compartment: 623923
is: http://identifiers.org/pubchem.compound/3309
initial concentration: 5.05E-5
boundary condition: false
is: C00007
has only substance units: false
constant: false
name: O2_r
is: http://identifiers.org/cas/7782-44-7

628279
type: Species
name: Citrate_c
has only substance units: false
is: http://identifiers.org/pubchem.compound/3458
initial concentration: 0.0105
boundary condition: false
is: C00158
constant: false
initial amount: NaN
is: CHEBI:30769
is: http://identifiers.org/cas/77-92-9
in compartment: 623911

820500
type: Reaction
is: ENSMUSG00000032902
reactant: 820524
product: 820548
reversible: true
reactant: 820512
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
name: r2086
product: 820536

820524
type: SpeciesReference
stoichiometry: 1.0
species: 625207

625207
type: Species
in compartment: 623935
is: http://identifiers.org/cas/127-17-3
boundary condition: true
name: Pyruvate_s
is: CHEBI:32816
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
initial concentration: 0.00155
is: C00022
initial amount: NaN
constant: false

820548
type: SpeciesReference
stoichiometry: 1.0
species: 625195

625195
type: Species
is: http://identifiers.org/cas/127-17-3
name: Pyruvate_c
is: C00022
constant: false
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
in compartment: 623911
is: CHEBI:32816
initial amount: NaN
boundary condition: false
initial concentration: 0.00155

820512
type: SpeciesReference
stoichiometry: 1.0
species: 636643

636643
type: Species
boundary condition: false
is: CHEBI:1148
constant: false
name: 2-Hydroxybutyrate_c
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/pubchem.compound/8262
initial concentration: 2.6E-4
has only substance units: false
is: C05984

820536
type: SpeciesReference
stoichiometry: 1.0
species: 636655

636655
type: Species
name: 2-Hydroxybutyrate_s
is: http://identifiers.org/pubchem.compound/8262
has only substance units: false
is: C05984
boundary condition: true
initial concentration: 2.6E-4
is: CHEBI:1148
in compartment: 623935
constant: false
initial amount: NaN

819120
type: Reaction
is: ENSMUSG00000030492
product: 819156
product: 819168
name: r2063
fast: false
reversible: false
reactant: 819132
reactant: 819144
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

819156
type: SpeciesReference
stoichiometry: 1.0
species: 630067

819168
type: SpeciesReference
stoichiometry: 1.0
species: 626707

819132
type: SpeciesReference
stoichiometry: 1.0
species: 630079

630079
type: Species
initial amount: NaN
in compartment: 623935
is: http://identifiers.org/pubchem.compound/3621
name: Citrulline_s
is: CHEBI:16349
has only substance units: false
initial concentration: 2.6E-4
boundary condition: true
is: C00327
constant: false
is: http://identifiers.org/cas/372-75-8

819144
type: SpeciesReference
stoichiometry: 1.0
species: 626695

635311
type: Species
name: 3-Oxodecanoyl-CoA_m
initial amount: NaN
has only substance units: false
boundary condition: false
is: C05265
in compartment: 623863
constant: false
is: CHEBI:28528
initial concentration: 1.0E-5
is: http://identifiers.org/pubchem.compound/7652

663913
type: Constraint
message: Warning: Species concentration 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanate_p is out of the soft bounds.

656906
type: Constraint
message: Warning: Species concentration Glutaryl-CoA_m is out of the soft bounds.

737118
type: Reaction
product: 737142
reactant: 737130
notes: Transport reaction
fast: false
reversible: false
name: r1011

737142
type: SpeciesReference
stoichiometry: 1.0
species: 634723

634723
type: Species
initial concentration: 2.6E-4
boundary condition: false
is: http://identifiers.org/pubchem.compound/7159
constant: false
initial amount: NaN
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate_r
in compartment: 623923
is: C04554
has only substance units: false

737130
type: SpeciesReference
stoichiometry: 1.0
species: 634735

842040
type: Reaction
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: 842088
reactant: 842052
fast: false
name: r2380
product: 842076
reactant: 842064
reversible: true
is: ENSMUSG00000003528

842088
type: SpeciesReference
stoichiometry: 1.0
species: 628927

628927
type: Species
in compartment: 623863
boundary condition: false
initial amount: NaN
constant: false
name: Oxalate_m
is: http://identifiers.org/pubchem.compound/3509
is: http://identifiers.org/cas/144-62-7
is: CHEBI:16995
initial concentration: 2.6E-4
is: C00209
has only substance units: false

842052
type: SpeciesReference
stoichiometry: 1.0
species: 630906

630906
type: Species
is: http://identifiers.org/cas/585-84-2
is: CHEBI:32805
name: cis-Aconitate_m
has only substance units: false
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3707
in compartment: 623863
constant: false
initial concentration: 4.0E-7
is: C00417

842076
type: SpeciesReference
stoichiometry: 1.0
species: 630894

630894
type: Species
is: http://identifiers.org/pubchem.compound/3707
initial concentration: 4.0E-7
initial amount: NaN
is: CHEBI:32805
constant: false
has only substance units: false
in compartment: 623911
is: http://identifiers.org/cas/585-84-2
is: C00417
boundary condition: false
name: cis-Aconitate_c

842064
type: SpeciesReference
stoichiometry: 1.0
species: 628915

628915
type: Species
is: http://identifiers.org/pubchem.compound/3509
name: Oxalate_c
initial amount: NaN
initial concentration: 2.6E-4
boundary condition: false
is: C00209
has only substance units: false
in compartment: 623911
is: http://identifiers.org/cas/144-62-7
is: CHEBI:16995
constant: false

816540
type: Reaction
reactant: 816564
reactant: 816552
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
fast: false
product: 816588
name: r2020
is: ENSMUSG00000030492
product: 816576

816564
type: SpeciesReference
stoichiometry: 1.0
species: 628531

816552
type: SpeciesReference
stoichiometry: 1.0
species: 626167

816588
type: SpeciesReference
stoichiometry: 1.0
species: 628543

816576
type: SpeciesReference
stoichiometry: 1.0
species: 626155

798172
type: Reaction
product: 798220
reactant: 798208
reactant: 798184
product: 798232
product: 798244
notes: Y+LAT2 Utilized transport
fast: false
reactant: 798196
is: ENSMUSG00000031904
reversible: false
name: r1794

798220
type: SpeciesReference
stoichiometry: 1.0
species: 627007

798208
type: SpeciesReference
stoichiometry: 1.0
species: 633091

798184
type: SpeciesReference
stoichiometry: 1.0
species: 627019

798232
type: SpeciesReference
stoichiometry: 1.0
species: 626263

798244
type: SpeciesReference
stoichiometry: 1.0
species: 633079

798196
type: SpeciesReference
stoichiometry: 1.0
species: 626251

671736
type: Constraint
message: Warning: Species concentration Dihomo-gamma-linolenate_l is out of the soft bounds.

689861
type: Reaction
product: 689885
reactant: 689873
notes: D-Glucose-6-phosphate ketol-isomerase EC:5.3.1.9
is: R00771
is: ENSMUSG00000036427
fast: false
reversible: true
name: r0192

689885
type: SpeciesReference
stoichiometry: 1.0
species: 626815

689873
type: SpeciesReference
stoichiometry: 1.0
species: 626899

626899
type: Species
name: Glucose-6P_c
is: CHEBI:4170
has only substance units: false
boundary condition: false
in compartment: 623911
is: C00092
is: http://identifiers.org/cas/56-73-5
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3392
constant: false
initial concentration: 0.0021

665521
type: Constraint
message: Warning: Species concentration 5beta-Cholestane-3alpha,7alpha,26-triol_m is out of the soft bounds.

794897
type: Reaction
reversible: false
reactant: 794909
is: ENSMUSG00000031904
name: r1755
product: 794969
product: 794957
reactant: 794933
product: 794945
fast: false
notes: Y+LAT2 Utilized transport
reactant: 794921

794909
type: SpeciesReference
stoichiometry: 1.0
species: 626551

794969
type: SpeciesReference
stoichiometry: 1.0
species: 633079

794957
type: SpeciesReference
stoichiometry: 1.0
species: 627571

794933
type: SpeciesReference
stoichiometry: 1.0
species: 633091

794945
type: SpeciesReference
stoichiometry: 1.0
species: 626539

794921
type: SpeciesReference
stoichiometry: 1.0
species: 627559

817740
type: Reaction
product: 817776
is: ENSMUSG00000030492
reactant: 817764
product: 817788
fast: false
reversible: false
name: r2040
reactant: 817752
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

817776
type: SpeciesReference
stoichiometry: 1.0
species: 627835

817764
type: SpeciesReference
stoichiometry: 1.0
species: 625627

817788
type: SpeciesReference
stoichiometry: 1.0
species: 625639

817752
type: SpeciesReference
stoichiometry: 1.0
species: 627847

677471
type: Constraint
message: Warning: Species concentration UDP-activated-xylose_c is out of the soft bounds.

636043
type: Species
has only substance units: false
constant: false
in compartment: 623911
is: http://identifiers.org/pubchem.compound/7872
is: CHEBI:5587
name: H2S2O3_c
is: C05529
boundary condition: false
initial amount: NaN
initial concentration: 2.6E-4

668664
type: Constraint
message: Warning: Species concentration Palmitolate_r is out of the soft bounds.

674736
type: Constraint
message: Warning: Species concentration prostaglandin-f2alpha_c is out of the soft bounds.

636151
type: Species
initial amount: NaN
is: C05635
boundary condition: false
in compartment: 623911
has only substance units: false
constant: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/7946
name: 5-Hydroxyindoleacetate_c

773335
type: Reaction
fast: false
product: 773371
reactant: 773347
is: ENSMUSG00000020777
notes: EC:1.3.3.6
is: ENSMUSG00000029098
reversible: false
product: 773383
name: r1442
reactant: 773359

773371
type: SpeciesReference
stoichiometry: 1.0
species: 635443

773347
type: SpeciesReference
stoichiometry: 1.0
species: 624631

773383
type: SpeciesReference
stoichiometry: 1.0
species: 625423

773359
type: SpeciesReference
stoichiometry: 1.0
species: 628255

628255
type: Species
is: C00154
name: Palmitoyl-CoA_p
is: CHEBI:15525
is: http://identifiers.org/cas/1763-10-6
constant: false
boundary condition: false
in compartment: 623899
initial concentration: 2.6E-4
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3454

883815
type: Reaction
reactant: 884075
reactant: 883841
reactant: 884088
reactant: 883854
product: 884114
name: r2636
reversible: false
fast: false
reactant: 883828
product: 884153
product: 884166
reactant: 884101
reactant: 883867
notes: Collagen alpha-1(XXVIII) chain Protein assembly
reactant: 883919
reactant: 883984
reactant: 883906
reactant: 883932
reactant: 884049
reactant: 883945
reactant: 883971
reactant: 883997
reactant: 884023
reactant: 884036
is: ENSMUSG00000068794
reactant: 884062
reactant: 883958
product: 884140
reactant: 884010
product: 884127
reactant: 883880
reactant: 883893

884075
type: SpeciesReference
stoichiometry: 18.0
species: 626695

883841
type: SpeciesReference
stoichiometry: 15.0
species: 627007

884088
type: SpeciesReference
stoichiometry: 4500.0
species: 624331

883854
type: SpeciesReference
stoichiometry: 63.0
species: 625867

884114
type: SpeciesReference
stoichiometry: 1.0
species: 641478

641478
type: Species
is: Q2UY09
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_COSA1_c

883828
type: SpeciesReference
stoichiometry: 42.0
species: 625675

884153
type: SpeciesReference
stoichiometry: 1125.0
species: 625135

884166
type: SpeciesReference
stoichiometry: 1125.0
species: 624919

884101
type: SpeciesReference
stoichiometry: 4500.0
species: 624259

883867
type: SpeciesReference
stoichiometry: 73.0
species: 625291

883919
type: SpeciesReference
stoichiometry: 61.0
species: 630798

883984
type: SpeciesReference
stoichiometry: 129.0
species: 628075

883906
type: SpeciesReference
stoichiometry: 7.0
species: 627835

883932
type: SpeciesReference
stoichiometry: 91.0
species: 625819

884049
type: SpeciesReference
stoichiometry: 53.0
species: 628531

883945
type: SpeciesReference
stoichiometry: 66.0
species: 627559

883971
type: SpeciesReference
stoichiometry: 27.0
species: 628147

883997
type: SpeciesReference
stoichiometry: 58.0
species: 626251

884023
type: SpeciesReference
stoichiometry: 69.0
species: 626299

884036
type: SpeciesReference
stoichiometry: 45.0
species: 628699

884062
type: SpeciesReference
stoichiometry: 5.0
species: 626539

883958
type: SpeciesReference
stoichiometry: 14.0
species: 626407

884140
type: SpeciesReference
stoichiometry: 3375.0
species: 624727

884010
type: SpeciesReference
stoichiometry: 40.0
species: 626155

884127
type: SpeciesReference
stoichiometry: 3375.0
species: 624655

883880
type: SpeciesReference
stoichiometry: 38.0
species: 626575

883893
type: SpeciesReference
stoichiometry: 211.0
species: 625627

663373
type: Constraint
message: Error: Species concentration (R)-4-Phosphopantothenoyl-cysteine_c is out of the hard bounds.

652946
type: Constraint
message: Warning: Species concentration Pyridoxal_s is out of the soft bounds.

841080
type: Reaction
product: 841104
reactant: 841092
notes: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
name: r2360

841104
type: SpeciesReference
stoichiometry: 1.0
species: 640158

640158
type: Species
is: C06438
is: http://identifiers.org/cas/17968-82-0
name: prostaglandin-d1_c
has only substance units: false
initial concentration: 2.6E-4
in compartment: 623911
constant: false
initial amount: NaN
is: CHEBI:27696
boundary condition: false
is: http://identifiers.org/pubchem.compound/8672

841092
type: SpeciesReference
stoichiometry: 1.0
species: 640170

883113
type: Reaction
reactant: 883139
reactant: 883399
reactant: 883360
product: 883438
reactant: 883373
reactant: 883295
name: r2634
reactant: 883282
reactant: 883178
reactant: 883230
reactant: 883321
product: 883425
reactant: 883204
product: 883464
reactant: 883152
fast: false
reactant: 883191
reversible: false
reactant: 883269
reactant: 883243
is: ENSMUSG00000045672
reactant: 883126
product: 883451
reactant: 883217
reactant: 883165
reactant: 883308
reactant: 883334
reactant: 883347
product: 883412
notes: Collagen alpha-1(XXVII) chain Protein assembly
reactant: 883386
reactant: 883256

883139
type: SpeciesReference
stoichiometry: 15.0
species: 627007

883399
type: SpeciesReference
stoichiometry: 7440.0
species: 624259

883360
type: SpeciesReference
stoichiometry: 10.0
species: 626539

883438
type: SpeciesReference
stoichiometry: 5580.0
species: 624727

883373
type: SpeciesReference
stoichiometry: 17.0
species: 626695

883295
type: SpeciesReference
stoichiometry: 96.0
species: 626251

883282
type: SpeciesReference
stoichiometry: 303.0
species: 628075

883178
type: SpeciesReference
stoichiometry: 49.0
species: 626575

883230
type: SpeciesReference
stoichiometry: 95.0
species: 625819

883321
type: SpeciesReference
stoichiometry: 106.0
species: 626299

883425
type: SpeciesReference
stoichiometry: 5580.0
species: 624655

883204
type: SpeciesReference
stoichiometry: 31.0
species: 627835

883464
type: SpeciesReference
stoichiometry: 1860.0
species: 624919

883152
type: SpeciesReference
stoichiometry: 69.0
species: 625867

883191
type: SpeciesReference
stoichiometry: 397.0
species: 625627

883269
type: SpeciesReference
stoichiometry: 21.0
species: 628147

883243
type: SpeciesReference
stoichiometry: 134.0
species: 627559

883126
type: SpeciesReference
stoichiometry: 110.0
species: 625675

883451
type: SpeciesReference
stoichiometry: 1860.0
species: 625135

883217
type: SpeciesReference
stoichiometry: 44.0
species: 630798

883165
type: SpeciesReference
stoichiometry: 67.0
species: 625291

883308
type: SpeciesReference
stoichiometry: 101.0
species: 626155

883334
type: SpeciesReference
stoichiometry: 87.0
species: 628699

883347
type: SpeciesReference
stoichiometry: 70.0
species: 628531

883412
type: SpeciesReference
stoichiometry: 1.0
species: 641466

641466
type: Species
is: Q8IZC6
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CORA1_c

883386
type: SpeciesReference
stoichiometry: 7440.0
species: 624331

883256
type: SpeciesReference
stoichiometry: 38.0
species: 626407

873209
type: Reaction
reactant: 873365
reactant: 873245
reactant: 873281
reactant: 873341
reactant: 873437
notes: Collagen alpha-1(XII) chain Protein assembly
reactant: 873221
reactant: 873377
product: 873497
product: 873509
reactant: 873473
reactant: 873269
reactant: 873413
reactant: 873257
product: 873521
reactant: 873317
reactant: 873293
reversible: false
product: 873485
reactant: 873449
reactant: 873389
reactant: 873353
reactant: 873425
is: ENSMUSG00000032332
reactant: 873233
reactant: 873329
name: r2604
reactant: 873401
product: 873533
reactant: 873461
reactant: 873305
fast: false

873365
type: SpeciesReference
stoichiometry: 263.0
species: 628075

873245
type: SpeciesReference
stoichiometry: 172.0
species: 625867

873281
type: SpeciesReference
stoichiometry: 281.0
species: 625627

873341
type: SpeciesReference
stoichiometry: 45.0
species: 626407

873437
type: SpeciesReference
stoichiometry: 30.0
species: 626539

873221
type: SpeciesReference
stoichiometry: 159.0
species: 625675

873377
type: SpeciesReference
stoichiometry: 104.0
species: 626251

873497
type: SpeciesReference
stoichiometry: 9189.0
species: 624655

873509
type: SpeciesReference
stoichiometry: 9189.0
species: 624727

873473
type: SpeciesReference
stoichiometry: 12252.0
species: 624259

873269
type: SpeciesReference
stoichiometry: 91.0
species: 626575

873413
type: SpeciesReference
stoichiometry: 266.0
species: 628699

873257
type: SpeciesReference
stoichiometry: 194.0
species: 625291

873521
type: SpeciesReference
stoichiometry: 3063.0
species: 625135

873317
type: SpeciesReference
stoichiometry: 156.0
species: 625819

873293
type: SpeciesReference
stoichiometry: 31.0
species: 627835

873485
type: SpeciesReference
stoichiometry: 1.0
species: 641286

641286
type: Species
is: Q99715
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_COCA1_c

873449
type: SpeciesReference
stoichiometry: 113.0
species: 626695

873389
type: SpeciesReference
stoichiometry: 157.0
species: 626155

873353
type: SpeciesReference
stoichiometry: 118.0
species: 628147

873425
type: SpeciesReference
stoichiometry: 270.0
species: 628531

873233
type: SpeciesReference
stoichiometry: 21.0
species: 627007

873329
type: SpeciesReference
stoichiometry: 203.0
species: 627559

873401
type: SpeciesReference
stoichiometry: 241.0
species: 626299

873533
type: SpeciesReference
stoichiometry: 3063.0
species: 624919

873461
type: SpeciesReference
stoichiometry: 12252.0
species: 624331

873305
type: SpeciesReference
stoichiometry: 148.0
species: 630798

807302
type: Reaction
reactant: 807314
product: 807362
name: r1902
reversible: false
reactant: 807338
fast: false
reactant: 807326
product: 807374
is: ENSMUSG00000031904
product: 807350
notes: Y+LAT2 Utilized transport

807314
type: SpeciesReference
stoichiometry: 1.0
species: 630810

807362
type: SpeciesReference
stoichiometry: 1.0
species: 626551

807338
type: SpeciesReference
stoichiometry: 1.0
species: 633091

807326
type: SpeciesReference
stoichiometry: 1.0
species: 626539

807374
type: SpeciesReference
stoichiometry: 1.0
species: 633079

807350
type: SpeciesReference
stoichiometry: 1.0
species: 630798

672960
type: Constraint
message: Warning: Species concentration Zinc_s is out of the soft bounds.

669516
type: Constraint
message: Error: Species concentration PI-pool_c is out of the hard bounds.

731371
type: Reaction
product: 731395
reactant: 731383
notes: Postulated transport reaction
fast: false
reversible: true
name: r0886

731395
type: SpeciesReference
stoichiometry: 1.0
species: 625999

625999
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/3357
is: http://identifiers.org/cas/63-37-6
has only substance units: false
name: CMP_r
is: CHEBI:17361
in compartment: 623923
initial amount: NaN
boundary condition: false
initial concentration: 2.6E-4
is: C00055

731383
type: SpeciesReference
stoichiometry: 1.0
species: 626011

626011
type: Species
is: http://identifiers.org/cas/63-37-6
constant: false
initial concentration: 2.6E-4
has only substance units: false
is: http://identifiers.org/pubchem.compound/3357
in compartment: 623911
boundary condition: false
name: CMP_c
is: CHEBI:17361
initial amount: NaN
is: C00055

643818
type: Constraint
message: Error: Species concentration CO2_p is out of the hard bounds.

648650
type: Constraint
message: Warning: Species concentration 2-Oxobutyrate_m is out of the soft bounds.

831418
type: Reaction
product: 831480
name: r2232
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: 831454
reactant: 831442
product: 831467
fast: false
is: ENSMUSG00000030236
reversible: true
reactant: 831430
product: 831493

831480
type: SpeciesReference
stoichiometry: 1.0
species: 629731

831454
type: SpeciesReference
stoichiometry: 1.0
species: 639990

831442
type: SpeciesReference
stoichiometry: 1.0
species: 629719

831467
type: SpeciesReference
stoichiometry: 1.0
species: 636511

636511
type: Species
initial amount: NaN
boundary condition: false
name: Bilirubin-bisglucuronoside_c
in compartment: 623911
is: CHEBI:18392
initial concentration: 2.6E-4
has only substance units: false
is: C05787
is: http://identifiers.org/pubchem.compound/8082
is: http://identifiers.org/cas/17459-92-6
constant: false

831430
type: SpeciesReference
stoichiometry: 1.0
species: 636523

636523
type: Species
is: http://identifiers.org/cas/17459-92-6
in compartment: 623935
initial amount: NaN
is: C05787
constant: false
name: Bilirubin-bisglucuronoside_s
is: http://identifiers.org/pubchem.compound/8082
is: CHEBI:18392
has only substance units: false
initial concentration: 2.6E-4
boundary condition: true

831493
type: SpeciesReference
stoichiometry: 1.0
species: 640002

708318
type: Reaction
product: 708342
reactant: 708330
notes: N-Acetyl-D-glucosamine 1-phosphate 1,6-phosphomutase Aminosugars metabolism EC:5.4.2.3
is: R02086
is: ENSMUSG00000056131
fast: false
reversible: false
name: r0491

708342
type: SpeciesReference
stoichiometry: 1.0
species: 634603

634603
type: Species
in compartment: 623911
is: http://identifiers.org/pubchem.compound/6921
name: N-Acetylglucosamine-1P_c
initial concentration: 2.6E-4
is: C04256
constant: false
is: CHEBI:7125
has only substance units: false
initial amount: NaN
boundary condition: false

708330
type: SpeciesReference
stoichiometry: 1.0
species: 630403

782142
type: Reaction
fast: false
reactant: 782166
is: ENSMUSG00000040010
reversible: true
name: r1576
product: 782190
product: 782178
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: 782154

782166
type: SpeciesReference
stoichiometry: 1.0
species: 626695

782190
type: SpeciesReference
stoichiometry: 1.0
species: 626707

782178
type: SpeciesReference
stoichiometry: 1.0
species: 626251

782154
type: SpeciesReference
stoichiometry: 1.0
species: 626263

736746
type: Reaction
product: 736794
product: 736782
reactant: 736770
reactant: 736758
notes: Facilitated diffusion
fast: false
reversible: true
name: r1004

736794
type: SpeciesReference
stoichiometry: 1.0
species: 640758

736782
type: SpeciesReference
stoichiometry: 1.0
species: 629971

736770
type: SpeciesReference
stoichiometry: 1.0
species: 640746

736758
type: SpeciesReference
stoichiometry: 1.0
species: 629983

634339
type: Species
has only substance units: false
name: 4-Imidazolone-5-propanoate_c
is: C03680
initial amount: NaN
in compartment: 623911
initial concentration: 2.6E-4
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/6455

631722
type: Species
is: http://identifiers.org/pubchem.compound/3881
is: C00606
constant: false
name: 3-Sulfinoalanine_c
is: http://identifiers.org/cas/1115-65-7
in compartment: 623911
initial amount: NaN
initial concentration: 2.6E-4
boundary condition: false
is: CHEBI:16345
has only substance units: false

757582
type: Reaction
product: 757606
reactant: 757594
notes: Postulated transport reaction
fast: false
reversible: true
name: r1291

757606
type: SpeciesReference
stoichiometry: 1.0
species: 627103

757594
type: SpeciesReference
stoichiometry: 1.0
species: 627091

627091
type: Species
is: http://identifiers.org/pubchem.compound/3400
is: C00100
name: Propanoyl-CoA_c
has only substance units: false
initial amount: NaN
initial concentration: 2.6E-4
constant: false
in compartment: 623911
boundary condition: false
is: http://identifiers.org/cas/317-66-8
is: CHEBI:15539

717412
type: Reaction
notes: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
is: ENSMUSG00000006344
name: r0641
is: R03867
reversible: true
reactant: 717424
product: 717460
fast: false
is: ENSMUSG00000027603
is: ENSMUSG00000006345
reactant: 717436
is: K00681
product: 717448
is: ENSMUSG00000040471

717424
type: SpeciesReference
stoichiometry: 1.0
species: 633607

633607
type: Species
initial amount: NaN
name: Leukotriene_C4_c
is: C02166
is: CHEBI:16978
has only substance units: false
in compartment: 623911
constant: false
is: http://identifiers.org/pubchem.compound/5241
boundary condition: false
is: http://identifiers.org/cas/72025-60-6
initial concentration: 2.6E-4

717460
type: SpeciesReference
stoichiometry: 1.0
species: 625291

717436
type: SpeciesReference
stoichiometry: 1.0
species: 624259

717448
type: SpeciesReference
stoichiometry: 1.0
species: 636595

636595
type: Species
initial amount: NaN
boundary condition: false
is: C05951
is: http://identifiers.org/pubchem.compound/8235
name: LTD4_c
in compartment: 623911
constant: false
has only substance units: false
initial concentration: 2.6E-4

635767
type: Species
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA_p
is: CHEBI:27458
initial amount: NaN
is: C05450
has only substance units: false
constant: false
initial concentration: 2.6E-4
boundary condition: false
in compartment: 623899
is: http://identifiers.org/pubchem.compound/7812

629455
type: Species
is: http://identifiers.org/cas/59-67-6
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Nicotinate_c

666061
type: Constraint
message: Error: Species concentration 3alpha,7alpha,12alpha-Trihydroxy-5beta-24-oxocholestanoyl-CoA_p is out of the hard bounds.

647354
type: Constraint
message: Warning: Species concentration H+(PG)_s is out of the soft bounds.

735294
type: Reaction
product: 735318
reactant: 735306
notes: Facilitated diffusion
fast: false
reversible: true
name: r0975

735318
type: SpeciesReference
stoichiometry: 1.0
species: 632395

632395
type: Species
in compartment: 623863
has only substance units: false
is: http://identifiers.org/cas/696-04-8
is: http://identifiers.org/pubchem.compound/4161
is: C00906
boundary condition: false
name: Dihydrothymine_m
constant: false
initial concentration: 2.6E-4
is: CHEBI:27468
initial amount: NaN

735306
type: SpeciesReference
stoichiometry: 1.0
species: 632383

632383
type: Species
is: C00906
boundary condition: false
is: http://identifiers.org/cas/696-04-8
name: Dihydrothymine_c
in compartment: 623911
constant: false
initial concentration: 2.6E-4
is: CHEBI:27468
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/4161

658574
type: Constraint
message: Error: Species concentration Deamido-NAD_c is out of the hard bounds.

654326
type: Constraint
message: Error: Species concentration Glucosamine_s is out of the hard bounds.

630295
type: Species
initial concentration: 2.6E-4
name: 6-Phospho-D-gluconate_c
boundary condition: false
is: CHEBI:48928
is: C00345
is: http://identifiers.org/pubchem.compound/3638
has only substance units: false
initial amount: NaN
constant: false
in compartment: 623911

625087
type: Species
initial concentration: 2.6E-4
is: CHEBI:18405
name: Pyridoxal-P_c
is: http://identifiers.org/cas/54-47-7
is: http://identifiers.org/pubchem.compound/3320
has only substance units: false
constant: false
in compartment: 623911
boundary condition: true
is: C00018
initial amount: NaN

775255
type: Reaction
notes: EC:4.2.1.17
name: r1475
reactant: 775267
fast: false
is: ENSMUSG00000025465
product: 775291
reversible: true
reactant: 775279
is: ENSMUSG00000025745

775267
type: SpeciesReference
stoichiometry: 1.0
species: 624295

775291
type: SpeciesReference
stoichiometry: 1.0
species: 640854

640854
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: (S)-3-hydroxypalmitoleoyl-CoA_m

775279
type: SpeciesReference
stoichiometry: 1.0
species: 640842

652070
type: Constraint
message: Error: Species concentration Thymidine_c is out of the hard bounds.

657566
type: Constraint
message: Error: Species concentration Pyridoxine-P_c is out of the hard bounds.

668208
type: Constraint
message: Warning: Species concentration HDL_r is out of the soft bounds.

853480
type: Reaction
product: 853669
product: 853693
product: 853743
product: 853632
product: 853531
fast: false
product: 853717
reversible: false
product: 853681
product: 853619
product: 853730
notes: Protein degradation
name: r2543
product: 853606
reactant: 853506
product: 853568
product: 853544
product: 853791
reactant: 853518
product: 853767
product: 853755
reactant: 853493
product: 853657
product: 853779
product: 853645
product: 853556
product: 853705
product: 853581
product: 853593

853669
type: SpeciesReference
stoichiometry: 40.0
species: 628147

853693
type: SpeciesReference
stoichiometry: 22.0
species: 626251

853743
type: SpeciesReference
stoichiometry: 47.0
species: 628531

853632
type: SpeciesReference
stoichiometry: 33.0
species: 625819

853531
type: SpeciesReference
stoichiometry: 61.0
species: 625675

853717
type: SpeciesReference
stoichiometry: 41.0
species: 626299

853681
type: SpeciesReference
stoichiometry: 31.0
species: 628075

853619
type: SpeciesReference
stoichiometry: 40.0
species: 630798

853730
type: SpeciesReference
stoichiometry: 46.0
species: 628699

853606
type: SpeciesReference
stoichiometry: 19.0
species: 627835

853506
type: SpeciesReference
stoichiometry: 341.5
species: 624331

853568
type: SpeciesReference
stoichiometry: 42.0
species: 625291

853544
type: SpeciesReference
stoichiometry: 11.0
species: 627007

853791
type: SpeciesReference
stoichiometry: 341.5
species: 624727

853518
type: SpeciesReference
stoichiometry: 341.5
species: 624259

853767
type: SpeciesReference
stoichiometry: 19.0
species: 626695

853755
type: SpeciesReference
stoichiometry: 2.0
species: 626539

853493
type: SpeciesReference
stoichiometry: 1.0
species: 640914

640914
type: Species
is: Q15582
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_BGH3_c

853657
type: SpeciesReference
stoichiometry: 14.0
species: 626407

853779
type: SpeciesReference
stoichiometry: 341.5
species: 624655

853645
type: SpeciesReference
stoichiometry: 87.0
species: 627559

853556
type: SpeciesReference
stoichiometry: 27.0
species: 625867

853705
type: SpeciesReference
stoichiometry: 37.0
species: 626155

853581
type: SpeciesReference
stoichiometry: 16.0
species: 626575

853593
type: SpeciesReference
stoichiometry: 48.0
species: 625627

654806
type: Constraint
message: Error: Species concentration HMG-CoA_c is out of the hard bounds.

653150
type: Constraint
message: Error: Species concentration Hypoxanthine_s is out of the hard bounds.

632203
type: Species
in compartment: 623911
boundary condition: false
is: C00785
is: http://identifiers.org/cas/104-98-3
initial concentration: 2.6E-4
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:30817
is: http://identifiers.org/pubchem.compound/4043
name: Urocanate_c

669084
type: Constraint
message: Error: Species concentration PC-VLDL-pool_s is out of the hard bounds.

665629
type: Constraint
message: Error: Species concentration 7alpha-Hydroxy-5beta-cholestan-3-one_c is out of the hard bounds.

860635
type: Reaction
notes: Protein degradation
product: 860887
product: 860815
product: 860899
product: 860779
product: 860707
product: 860863
fast: false
product: 860695
product: 860875
reactant: 860647
product: 860755
product: 860911
product: 860827
product: 860767
reversible: false
product: 860923
reactant: 860671
name: r2565
product: 860683
product: 860851
product: 860731
product: 860839
product: 860791
product: 860719
product: 860935
product: 860743
reactant: 860659
product: 860803

860887
type: SpeciesReference
stoichiometry: 50.0
species: 628531

860815
type: SpeciesReference
stoichiometry: 15.0
species: 628147

860899
type: SpeciesReference
stoichiometry: 9.0
species: 626539

860779
type: SpeciesReference
stoichiometry: 83.0
species: 625819

860707
type: SpeciesReference
stoichiometry: 72.0
species: 625867

860863
type: SpeciesReference
stoichiometry: 76.0
species: 626299

860695
type: SpeciesReference
stoichiometry: 32.0
species: 627007

860875
type: SpeciesReference
stoichiometry: 30.0
species: 628699

860647
type: SpeciesReference
stoichiometry: 1.0
species: 641046

860755
type: SpeciesReference
stoichiometry: 33.0
species: 627835

860911
type: SpeciesReference
stoichiometry: 23.0
species: 626695

860827
type: SpeciesReference
stoichiometry: 345.0
species: 628075

860767
type: SpeciesReference
stoichiometry: 43.0
species: 630798

860923
type: SpeciesReference
stoichiometry: 845.0
species: 624655

860671
type: SpeciesReference
stoichiometry: 845.0
species: 624259

860683
type: SpeciesReference
stoichiometry: 69.0
species: 625675

860851
type: SpeciesReference
stoichiometry: 70.0
species: 626155

860731
type: SpeciesReference
stoichiometry: 45.0
species: 626575

860839
type: SpeciesReference
stoichiometry: 48.0
species: 626251

860791
type: SpeciesReference
stoichiometry: 101.0
species: 627559

860719
type: SpeciesReference
stoichiometry: 58.0
species: 625291

860935
type: SpeciesReference
stoichiometry: 845.0
species: 624727

860743
type: SpeciesReference
stoichiometry: 464.0
species: 625627

860659
type: SpeciesReference
stoichiometry: 845.0
species: 624331

860803
type: SpeciesReference
stoichiometry: 24.0
species: 626407

798508
type: Reaction
notes: Y+LAT2 Utilized transport
reactant: 798520
fast: false
reversible: false
reactant: 798544
reactant: 798532
product: 798556
product: 798580
is: ENSMUSG00000031904
name: r1798
product: 798568

798520
type: SpeciesReference
stoichiometry: 1.0
species: 627019

798544
type: SpeciesReference
stoichiometry: 1.0
species: 633091

798532
type: SpeciesReference
stoichiometry: 1.0
species: 626575

798556
type: SpeciesReference
stoichiometry: 1.0
species: 627007

798580
type: SpeciesReference
stoichiometry: 1.0
species: 633079

798568
type: SpeciesReference
stoichiometry: 1.0
species: 626587

624127
type: Species
is: P04114
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623851
name: ApoB100_l

653378
type: Constraint
message: Warning: Species concentration H2S_c is out of the soft bounds.

808645
type: Reaction
reactant: 808657
product: 808705
is: ENSMUSG00000031904
fast: false
reversible: false
notes: Y+LAT2 Utilized transport
reactant: 808681
name: r1918
product: 808693
reactant: 808669
product: 808717

808657
type: SpeciesReference
stoichiometry: 1.0
species: 625687

808705
type: SpeciesReference
stoichiometry: 1.0
species: 633079

808681
type: SpeciesReference
stoichiometry: 1.0
species: 626155

808693
type: SpeciesReference
stoichiometry: 1.0
species: 625675

808669
type: SpeciesReference
stoichiometry: 1.0
species: 633091

808717
type: SpeciesReference
stoichiometry: 1.0
species: 626167

630990
type: Species
is: C00439
constant: false
is: http://identifiers.org/pubchem.compound/3728
initial amount: NaN
in compartment: 623911
initial concentration: 2.6E-4
has only substance units: false
name: N-Formimino-L-glutamate_c
boundary condition: false
is: CHEBI:7274

659893
type: Constraint
message: Error: Species concentration Nicotinate_ribonucleotide_c is out of the hard bounds.

669480
type: Constraint
message: Warning: Species concentration Glucosylceramide-pool_s is out of the soft bounds.

719116
type: Reaction
name: r0668
is: ENSMUSG00000030282
fast: false
notes: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
is: R04215
product: 719164
reactant: 719128
is: K00983
reactant: 719140
reversible: true
product: 719152

719164
type: SpeciesReference
stoichiometry: 1.0
species: 634375

634375
type: Species
initial concentration: 2.6E-4
is: CHEBI:18098
boundary condition: false
constant: false
in compartment: 623911
has only substance units: false
initial amount: NaN
name: CMP-NeuNGc_c
is: C03691
is: http://identifiers.org/pubchem.compound/6465

719128
type: SpeciesReference
stoichiometry: 1.0
species: 634255

634255
type: Species
is: http://identifiers.org/pubchem.compound/6239
is: CHEBI:29025
is: C03410
has only substance units: false
boundary condition: false
in compartment: 623911
initial concentration: 2.6E-4
initial amount: NaN
name: NeuNGc_c
constant: false

719140
type: SpeciesReference
stoichiometry: 1.0
species: 626203

626203
type: Species
initial amount: NaN
boundary condition: true
initial concentration: 2.6E-4
in compartment: 623911
constant: false
has only substance units: false
is: http://identifiers.org/cas/65-47-4
is: C00063
is: CHEBI:17677
is: http://identifiers.org/pubchem.compound/3363
name: CTP_c

719152
type: SpeciesReference
stoichiometry: 1.0
species: 624919

698440
type: Reaction
name: r0332
product: 698488
notes: 5,6-Dihydrothymine:NADP+ oxidoreductase Pyrimidine metabolism EC:1.3.1.2
is: K00207
reactant: 698464
product: 698476
is: R01415
fast: false
reactant: 698452
is: ENSMUSG00000033308
reversible: true

698488
type: SpeciesReference
stoichiometry: 1.0
species: 624499

698464
type: SpeciesReference
stoichiometry: 1.0
species: 624547

698476
type: SpeciesReference
stoichiometry: 1.0
species: 628483

628483
type: Species
in compartment: 623911
is: CHEBI:17821
initial amount: NaN
name: Thymine_c
is: http://identifiers.org/cas/65-71-4
is: C00178
has only substance units: false
is: http://identifiers.org/pubchem.compound/3478
boundary condition: false
constant: false
initial concentration: 2.6E-4

698452
type: SpeciesReference
stoichiometry: 1.0
species: 632383

673392
type: Constraint
message: Warning: Species concentration leukotriene-f4_s is out of the soft bounds.

643890
type: Constraint
message: Error: Species concentration PPi_s is out of the hard bounds.

642030
type: Constraint
message: Warning: Species concentration Antichymotrypsin_s is out of the soft bounds.

628459
type: Species
initial concentration: 2.6E-4
name: Carbamoyl-P_m
boundary condition: false
in compartment: 623863
is: C00169
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3469
has only substance units: false
is: CHEBI:17672

656258
type: Constraint
message: Warning: Species concentration Nicotinamide_D-ribonucleotide_c is out of the soft bounds.

660781
type: Constraint
message: Error: Species concentration L-Fuculose_c is out of the hard bounds.

634279
type: Species
has only substance units: false
constant: false
initial amount: NaN
in compartment: 623863
boundary condition: false
is: CHEBI:27754
is: C03460
is: http://identifiers.org/pubchem.compound/6280
initial concentration: 2.6E-4
name: Methacrylyl-CoA_m

664093
type: Constraint
message: Error: Species concentration 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin_s is out of the hard bounds.

636667
type: Species
boundary condition: false
initial amount: NaN
in compartment: 623911
is: http://identifiers.org/pubchem.compound/440867
has only substance units: false
initial concentration: 2.6E-4
is: CHEBI:37666
constant: false
name: Acetyl_adenylate_c

670632
type: Constraint
message: Warning: Species concentration 1,2-Diacylglycerol-VLDL-PI-pool_c is out of the soft bounds.

774787
type: Reaction
product: 774811
reactant: 774799
notes: Postulated transport reaction
fast: false
reversible: true
name: r1467

774811
type: SpeciesReference
stoichiometry: 1.0
species: 631350

774799
type: SpeciesReference
stoichiometry: 1.0
species: 631338

829235
type: Reaction
product: 829295
is: ENSMUSG00000063975
product: 829283
name: r2206
is: ENSMUSG00000079262
is: ENSMUSG00000030237
fast: false
reactant: 829247
reactant: 829271
is: ENSMUSG00000041698
reactant: 829259
product: 829307
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true

829295
type: SpeciesReference
stoichiometry: 1.0
species: 629731

829283
type: SpeciesReference
stoichiometry: 1.0
species: 633451

633451
type: Species
has only substance units: false
constant: false
is: C01829
initial concentration: 2.6E-4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4950
is: http://identifiers.org/cas/51-48-9
in compartment: 623911
is: CHEBI:18332
name: O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine_c
boundary condition: false

829247
type: SpeciesReference
stoichiometry: 1.0
species: 633463

633463
type: Species
name: O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine_s
is: CHEBI:18332
is: C01829
in compartment: 623935
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/4950
initial amount: NaN
is: http://identifiers.org/cas/51-48-9

829271
type: SpeciesReference
stoichiometry: 1.0
species: 639918

829259
type: SpeciesReference
stoichiometry: 1.0
species: 629719

829307
type: SpeciesReference
stoichiometry: 1.0
species: 639930

634171
type: Species
is: http://identifiers.org/pubchem.compound/6144
constant: false
initial amount: NaN
boundary condition: false
name: Glutamyl-5P_m
is: C03287
is: CHEBI:17798
has only substance units: false
in compartment: 623863
initial concentration: 2.6E-4

638310
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: Triacylglycerol-VLDL-pool_r

628195
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Nicotinamide_c

747335
type: Reaction
product: 747359
reactant: 747347
notes: Transport reaction
fast: false
reversible: false
name: r1130

747359
type: SpeciesReference
stoichiometry: 1.0
species: 624091

624091
type: Species
is: P02647
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623851
name: ApoA1_l

747347
type: SpeciesReference
stoichiometry: 1.0
species: 624079

658442
type: Constraint
message: Warning: Species concentration Serotonin_c is out of the soft bounds.

816840
type: Reaction
reactant: 816852
is: ENSMUSG00000030492
reactant: 816864
fast: false
name: r2025
product: 816876
reversible: false
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: 816888

816852
type: SpeciesReference
stoichiometry: 1.0
species: 626515

626515
type: Species
in compartment: 623935
initial amount: NaN
boundary condition: true
name: Ornithine_s
is: http://identifiers.org/pubchem.compound/3377
is: CHEBI:15729
has only substance units: false
constant: false
is: http://identifiers.org/cas/70-26-8
initial concentration: 2.6E-4
is: C00077

816864
type: SpeciesReference
stoichiometry: 1.0
species: 625675

816876
type: SpeciesReference
stoichiometry: 1.0
species: 626503

816888
type: SpeciesReference
stoichiometry: 1.0
species: 625687

799768
type: Reaction
reactant: 799804
is: ENSMUSG00000031904
notes: Y+LAT2 Utilized transport
product: 799828
reactant: 799780
reactant: 799792
product: 799840
name: r1813
reversible: false
product: 799816
fast: false

799804
type: SpeciesReference
stoichiometry: 1.0
species: 633091

799828
type: SpeciesReference
stoichiometry: 1.0
species: 626587

799780
type: SpeciesReference
stoichiometry: 1.0
species: 627571

799792
type: SpeciesReference
stoichiometry: 1.0
species: 626575

799840
type: SpeciesReference
stoichiometry: 1.0
species: 633079

799816
type: SpeciesReference
stoichiometry: 1.0
species: 627559

665245
type: Constraint
message: Error: Species concentration Oxalosuccinate_m is out of the hard bounds.

630163
type: Species
in compartment: 623863
name: Deoxyguanosine_m
is: C00330
initial concentration: 2.6E-4
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3624
boundary condition: false
initial amount: NaN
is: CHEBI:17172
is: http://identifiers.org/cas/961-07-9

641814
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623863
name: CoA-activated_acetyl_group_m

647882
type: Constraint
message: Warning: Species concentration Glucose-6P_c is out of the soft bounds.

669780
type: Constraint
message: Error: Species concentration Cholesterol-ester-ol_l is out of the hard bounds.

673932
type: Constraint
message: Error: Species concentration glutathionyl-leuc4_s is out of the hard bounds.

752639
type: Reaction
fast: false
reactant: 752663
product: 752687
notes: Glycerolipid metabolism / Glycerophospholipid metabolism EC:2.3.1.51
is: ENSMUSG00000038732
is: R02241
is: ENSMUSG00000020646
reactant: 752651
is: ENSMUSG00000023827
is: ENSMUSG00000026922
is: ENSMUSG00000001211
is: K13523
name: r1215
reversible: true
is: K00655
is: K13517
product: 752675
is: K13509
is: ENSMUSG00000034254
is: K13519
is: K13513

752663
type: SpeciesReference
stoichiometry: 1.0
species: 624799

752687
type: SpeciesReference
stoichiometry: 1.0
species: 638130

638130
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Acyl-CoA-VLDL-PI-pool_c

752651
type: SpeciesReference
stoichiometry: 1.0
species: 638202

638202
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Phosphatidate-VLDL-PI-pool_c

752675
type: SpeciesReference
stoichiometry: 1.0
species: 638058

638058
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1-Acylglycerol-3P-VLDL-PI-pool_c

665749
type: Constraint
message: Error: Species concentration 3alpha,7alpha,12alpha-Trihydroxycoprostane_m is out of the hard bounds.

822480
type: Reaction
name: r2119
is: ENSMUSG00000032902
reversible: true
reactant: 822492
reactant: 822504
fast: false
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: 822528
product: 822516

822492
type: SpeciesReference
stoichiometry: 1.0
species: 626071

626071
type: Species
initial concentration: 2.6E-4
is: CHEBI:30751
in compartment: 623935
name: Formate_s
constant: false
is: http://identifiers.org/cas/64-18-6
boundary condition: true
is: C00058
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3358

822504
type: SpeciesReference
stoichiometry: 1.0
species: 632143

822528
type: SpeciesReference
stoichiometry: 1.0
species: 632155

822516
type: SpeciesReference
stoichiometry: 1.0
species: 626059

626059
type: Species
in compartment: 623911
is: CHEBI:30751
name: Formate_c
is: http://identifiers.org/cas/64-18-6
is: C00058
has only substance units: false
is: http://identifiers.org/pubchem.compound/3358
initial amount: NaN
initial concentration: 2.6E-4
constant: false
boundary condition: false

657434
type: Constraint
message: Warning: Species concentration Guanidinoacetate_c is out of the soft bounds.

662413
type: Constraint
message: Error: Species concentration Glutamyl-5P_m is out of the hard bounds.

736266
type: Reaction
fast: false
name: r0996
notes: CAT Transport reaction
reversible: true
product: 736314
reactant: 736290
product: 736302
reactant: 736278
is: ENSMUSG00000026853

736314
type: SpeciesReference
stoichiometry: 1.0
species: 633859

736290
type: SpeciesReference
stoichiometry: 1.0
species: 633883

633883
type: Species
is: C02571
constant: false
is: http://identifiers.org/pubchem.compound/5567
is: CHEBI:15960
in compartment: 623899
name: O-Acetylcarnitine_p
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN

736302
type: SpeciesReference
stoichiometry: 1.0
species: 630007

736278
type: SpeciesReference
stoichiometry: 1.0
species: 629983

659773
type: Constraint
message: Error: Species concentration Provitamin_D3_r is out of the hard bounds.

665641
type: Constraint
message: Warning: Species concentration 7alpha-Hydroxy-5beta-cholestan-3-one_c is out of the soft bounds.

666456
type: Constraint
message: Warning: Species concentration 3-Hydroxypropionyl-CoA_m is out of the soft bounds.

837277
type: Reaction
reversible: true
fast: false
product: 837337
reactant: 837313
product: 837325
name: r2301
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: 837349
reactant: 837289
reactant: 837301
is: ENSMUSG00000030236

837337
type: SpeciesReference
stoichiometry: 1.0
species: 629731

837313
type: SpeciesReference
stoichiometry: 1.0
species: 639990

837325
type: SpeciesReference
stoichiometry: 1.0
species: 640374

640374
type: Species
is: http://identifiers.org/pubchem.compound/8240
constant: false
is: C05956
is: CHEBI:27647
has only substance units: false
in compartment: 623911
boundary condition: false
is: http://identifiers.org/cas/51982-36-6
initial concentration: 2.6E-4
initial amount: NaN
name: prostaglandin-g2_c

837349
type: SpeciesReference
stoichiometry: 1.0
species: 640002

837289
type: SpeciesReference
stoichiometry: 1.0
species: 640386

837301
type: SpeciesReference
stoichiometry: 1.0
species: 629719

668856
type: Constraint
message: Warning: Species concentration gamma-Linolenoyl-CoA_r is out of the soft bounds.

661405
type: Constraint
message: Error: Species concentration Protoporphyrin_m is out of the hard bounds.

677675
type: Constraint
message: Error: Species concentration CoA-activated_acetyl_group_c is out of the hard bounds.

632755
type: Species
is: CHEBI:16858
constant: false
initial concentration: 2.6E-4
has only substance units: false
is: http://identifiers.org/pubchem.compound/4365
in compartment: 623911
name: Phosphopantetheine_c
is: C01134
initial amount: NaN
boundary condition: false

633211
type: Species
is: http://identifiers.org/cas/57-11-4
is: CHEBI:25629
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/4692
in compartment: 623911
initial concentration: 2.6E-4
initial amount: NaN
boundary condition: false
is: C01530
name: Stearate_c

755939
type: Reaction
is: ENSMUSG00000027359
is: ENSMUSG00000031278
is: ENSMUSG00000024207
is: ENSMUSG00000032883
reactant: 755975
product: 755999
reactant: 755951
name: r1262
product: 756011
product: 755987
is: ENSMUSG00000020333
reactant: 755963
reversible: false
notes: EC:6.2.1.3
is: ENSMUSG00000024981
is: ENSMUSG00000018796
fast: false
is: ENSMUSG00000032281

755975
type: SpeciesReference
stoichiometry: 1.0
species: 624787

755999
type: SpeciesReference
stoichiometry: 1.0
species: 625123

625123
type: Species
constant: false
is: CHEBI:16027
in compartment: 623923
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3322
initial concentration: 4.2E-4
is: http://identifiers.org/cas/61-19-8
initial amount: NaN
is: C00020
name: AMP_r

755951
type: SpeciesReference
stoichiometry: 1.0
species: 629035

629035
type: Species
name: Arachidonate_r
initial amount: NaN
is: http://identifiers.org/cas/506-32-1
has only substance units: false
in compartment: 623923
is: CHEBI:15843
is: C00219
constant: false
is: http://identifiers.org/pubchem.compound/3519
initial concentration: 2.6E-4
boundary condition: false

756011
type: SpeciesReference
stoichiometry: 1.0
species: 624907

624907
type: Species
in compartment: 623923
is: CHEBI:18361
is: C00013
name: PPi_r
is: http://identifiers.org/cas/2466-09-3
has only substance units: false
initial concentration: 1.0E-8
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3315
initial amount: NaN

755987
type: SpeciesReference
stoichiometry: 1.0
species: 637411

637411
type: Species
is: C02249
is: http://identifiers.org/pubchem.compound/5312
initial amount: NaN
initial concentration: 2.6E-4
name: Arachidonyl-CoA_r
has only substance units: false
is: CHEBI:15514
is: http://identifiers.org/cas/17046-56-9
boundary condition: false
constant: false
in compartment: 623923

755963
type: SpeciesReference
stoichiometry: 1.0
species: 624319

624319
type: Species
boundary condition: false
has only substance units: false
is: http://identifiers.org/cas/56-65-5
is: C00002
initial concentration: 3.38E-4
is: http://identifiers.org/pubchem.compound/3304
initial amount: NaN
is: CHEBI:15422
constant: false
in compartment: 623923
name: ATP_r

649022
type: Constraint
message: Error: Species concentration GAP_c is out of the hard bounds.

658765
type: Constraint
message: Error: Species concentration Dephospho-CoA_m is out of the hard bounds.

722456
type: Reaction
is: R04741
is: K07515
is: ENSMUSG00000027984
product: 722504
is: K07514
is: ENSMUSG00000022853
reactant: 722468
notes: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
name: r0722
is: ENSMUSG00000025745
reactant: 722480
is: K01782
fast: false
is: K00022
reversible: true
product: 722492
is: K01825
is: K07516

722504
type: SpeciesReference
stoichiometry: 1.0
species: 624463

722468
type: SpeciesReference
stoichiometry: 1.0
species: 635239

635239
type: Species
is: C05262
initial amount: NaN
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/7649
has only substance units: false
constant: false
is: CHEBI:27668
in compartment: 623863
name: (S)-3-Hydroxydodecanoyl-CoA_m
boundary condition: false

722480
type: SpeciesReference
stoichiometry: 1.0
species: 624415

722492
type: SpeciesReference
stoichiometry: 1.0
species: 635263

635263
type: Species
constant: false
is: CHEBI:27868
in compartment: 623863
initial amount: NaN
initial concentration: 1.0E-5
has only substance units: false
name: 3-Oxododecanoyl-CoA_m
boundary condition: false
is: C05263
is: http://identifiers.org/pubchem.compound/7650

701356
type: Reaction
reactant: 701368
reversible: true
is: R01681
product: 701416
reactant: 701380
notes: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
product: 701404
name: r0381
fast: false
reactant: 701392

701368
type: SpeciesReference
stoichiometry: 1.0
species: 624403

701416
type: SpeciesReference
stoichiometry: 1.0
species: 629287

629287
type: Species
is: http://identifiers.org/pubchem.compound/3544
has only substance units: false
is: CHEBI:15891
in compartment: 623911
name: Taurine_c
initial concentration: 2.6E-4
boundary condition: false
initial amount: NaN
is: http://identifiers.org/cas/107-35-7
constant: false
is: C00245

701380
type: SpeciesReference
stoichiometry: 1.0
species: 624259

701404
type: SpeciesReference
stoichiometry: 1.0
species: 624451

701392
type: SpeciesReference
stoichiometry: 1.0
species: 631374

822360
type: Reaction
product: 822396
is: ENSMUSG00000032902
name: r2117
reactant: 822384
reactant: 822372
fast: false
product: 822408
reversible: true
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1

822396
type: SpeciesReference
stoichiometry: 1.0
species: 626059

822384
type: SpeciesReference
stoichiometry: 1.0
species: 628591

822372
type: SpeciesReference
stoichiometry: 1.0
species: 626071

822408
type: SpeciesReference
stoichiometry: 1.0
species: 628603

847895
type: Reaction
name: r2470
is: ENSMUSG00000020261
fast: false
notes: Major Facilitator(MFS) TCDB:2.A.18.8.1
reversible: false
reactant: 847919
product: 847931
product: 847943
reactant: 847907

847919
type: SpeciesReference
stoichiometry: 1.0
species: 626635

847931
type: SpeciesReference
stoichiometry: 1.0
species: 628075

847943
type: SpeciesReference
stoichiometry: 1.0
species: 626623

847907
type: SpeciesReference
stoichiometry: 1.0
species: 628087

660109
type: Constraint
message: Error: Species concentration GDP-4-dehydro-6-deoxy-D-mannose_c is out of the hard bounds.

699400
type: Reaction
reactant: 699412
product: 699436
reactant: 699424
is: R01567
name: r0348
product: 699448
notes: ATP:thymidine 5'-phosphotransferase Pyrimidine metabolism EC:2.7.1.21
fast: false
is: ENSMUSG00000025574
reversible: false
is: K00857

699412
type: SpeciesReference
stoichiometry: 1.0
species: 624331

699436
type: SpeciesReference
stoichiometry: 1.0
species: 624655

699424
type: SpeciesReference
stoichiometry: 1.0
species: 628999

628999
type: Species
is: http://identifiers.org/cas/50-89-5
is: CHEBI:17748
constant: false
in compartment: 623911
is: C00214
has only substance units: false
is: http://identifiers.org/pubchem.compound/3514
boundary condition: false
name: Thymidine_c
initial concentration: 2.6E-4
initial amount: NaN

699448
type: SpeciesReference
stoichiometry: 1.0
species: 630511

776407
type: Reaction
reactant: 776419
reversible: false
fast: false
product: 776443
reactant: 776431
is: ENSMUSG00000021135
product: 776455
notes: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
name: r1494

776419
type: SpeciesReference
stoichiometry: 1.0
species: 633535

776443
type: SpeciesReference
stoichiometry: 1.0
species: 633523

776431
type: SpeciesReference
stoichiometry: 2.0
species: 633091

776455
type: SpeciesReference
stoichiometry: 2.0
species: 633079

640722
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: (S)-3-hydroxyoleyleoyl-CoA_m

845063
type: Reaction
product: 845111
product: 845099
reactant: 845087
reactant: 845075
notes: ANT 2 Utilized transport
fast: false
reversible: false
name: r2418

845111
type: SpeciesReference
stoichiometry: 1.0
species: 624331

845099
type: SpeciesReference
stoichiometry: 1.0
species: 624691

845087
type: SpeciesReference
stoichiometry: 1.0
species: 624367

845075
type: SpeciesReference
stoichiometry: 1.0
species: 624655

661801
type: Constraint
message: Warning: Species concentration O-Acetylcarnitine_c is out of the soft bounds.

658801
type: Constraint
message: Warning: Species concentration Homocarnosine_c is out of the soft bounds.

775363
type: Reaction
reversible: true
is: ENSMUSG00000027984
product: 775399
reactant: 775387
fast: false
reactant: 775375
is: ENSMUSG00000025260
name: r1477
is: ENSMUSG00000022853
notes: EC:1.1.1.35
product: 775411

775399
type: SpeciesReference
stoichiometry: 1.0
species: 624463

775387
type: SpeciesReference
stoichiometry: 1.0
species: 640722

775375
type: SpeciesReference
stoichiometry: 1.0
species: 624415

775411
type: SpeciesReference
stoichiometry: 1.0
species: 640734

640734
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: 3-oxooleoyl-CoA_m

648770
type: Constraint
message: Warning: Species concentration CDP_s is out of the soft bounds.

773191
type: Reaction
product: 773215
reactant: 773203
notes: Transport reaction
fast: false
reversible: false
name: r1438

773215
type: SpeciesReference
stoichiometry: 1.0
species: 627595

627595
type: Species
name: Leucine_m
is: CHEBI:15603
has only substance units: false
constant: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/61-90-5
is: C00123
in compartment: 623863
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3423

773203
type: SpeciesReference
stoichiometry: 1.0
species: 627559

627199
type: Species
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3405
in compartment: 623923
is: C00105
name: UMP_r
initial amount: NaN
is: http://identifiers.org/cas/58-97-9
constant: false
is: CHEBI:16695
initial concentration: 2.6E-4

773047
type: Reaction
product: 773071
reactant: 773059
notes: Transport reaction
fast: false
reversible: false
name: r1434

773071
type: SpeciesReference
stoichiometry: 1.0
species: 625711

625711
type: Species
is: CHEBI:16977
is: http://identifiers.org/cas/56-41-7
has only substance units: false
is: C00041
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3343
in compartment: 623863
boundary condition: false
name: Alanine_m
initial concentration: 2.6E-4

773059
type: SpeciesReference
stoichiometry: 1.0
species: 625675

634147
type: Species
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 2.6E-4
is: C03232
is: http://identifiers.org/pubchem.compound/6103
in compartment: 623911
name: 3-Phosphonooxypyruvate_c
has only substance units: false
is: CHEBI:30933

636535
type: Species
in compartment: 623911
boundary condition: false
initial amount: NaN
constant: false
name: Nicotinate_D-ribonucleoside_c
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/161234
has only substance units: false
is: CHEBI:27748

635683
type: Species
has only substance units: false
name: Zymosterol_r
is: C05437
is: http://identifiers.org/cas/128-33-6
is: CHEBI:18252
constant: false
in compartment: 623923
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/7800
initial amount: NaN
boundary condition: false

740166
type: Reaction
product: 740190
reactant: 740178
notes: TCDB:2.A.3.8.1 TCDB:2.A.1.13.2
is: ENSMUSG00000040010
is: ENSMUSG00000019838
fast: false
reversible: true
name: r1079

740190
type: SpeciesReference
stoichiometry: 1.0
species: 626695

740178
type: SpeciesReference
stoichiometry: 1.0
species: 626707

660505
type: Constraint
message: Warning: Species concentration Stearate_c is out of the soft bounds.

628063
type: Species
name: Adenine_s
has only substance units: false
is: C00147
constant: false
initial concentration: 2.6E-4
boundary condition: true
is: http://identifiers.org/pubchem.compound/3447
is: http://identifiers.org/cas/73-24-5
in compartment: 623935
is: CHEBI:16708
initial amount: NaN

705378
type: Reaction
is: K08766
reactant: 705390
product: 705426
name: r0446
reversible: true
is: K08765
is: R01923
is: ENSMUSG00000028607
fast: false
notes: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: ENSMUSG00000024900
product: 705414
reactant: 705402

705390
type: SpeciesReference
stoichiometry: 1.0
species: 640614

705426
type: SpeciesReference
stoichiometry: 1.0
species: 640662

705414
type: SpeciesReference
stoichiometry: 1.0
species: 624811

705402
type: SpeciesReference
stoichiometry: 1.0
species: 629995

675636
type: Constraint
message: Error: Species concentration Malonyl-Carnitin_p is out of the hard bounds.

640290
type: Species
is: http://identifiers.org/cas/802-31-3
is: http://identifiers.org/pubchem.compound/8673
initial amount: NaN
in compartment: 623935
is: CHEBI:28031
initial concentration: 2.6E-4
boundary condition: false
name: prostaglandin-e3_s
has only substance units: false
is: C06439
constant: false

723368
type: Reaction
is: ENSMUSG00000031168
name: r0738
reactant: 723380
reversible: true
fast: false
is: K01824
notes: delta8,24-Cholestadien-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
product: 723392
is: R04804

723380
type: SpeciesReference
stoichiometry: 1.0
species: 635683

723392
type: SpeciesReference
stoichiometry: 1.0
species: 635695

635695
type: Species
name: 5alpha-Cholesta-7,24-dien-3beta-ol_r
is: CHEBI:16290
initial amount: NaN
has only substance units: false
boundary condition: false
is: C05439
is: http://identifiers.org/pubchem.compound/7801
constant: false
in compartment: 623923
initial concentration: 2.6E-4

826967
type: Reaction
product: 827039
reactant: 827003
is: ENSMUSG00000041698
fast: false
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000079262
reactant: 826991
is: ENSMUSG00000063975
reversible: true
reactant: 826979
name: r2179
product: 827027
is: ENSMUSG00000030237
product: 827015

827039
type: SpeciesReference
stoichiometry: 1.0
species: 639966

827003
type: SpeciesReference
stoichiometry: 1.0
species: 639954

826991
type: SpeciesReference
stoichiometry: 1.0
species: 629719

826979
type: SpeciesReference
stoichiometry: 1.0
species: 639822

639822
type: Species
is: http://identifiers.org/pubchem.compound/9848818
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623935
name: tauroursodeoxycholate_s

827027
type: SpeciesReference
stoichiometry: 1.0
species: 629731

827015
type: SpeciesReference
stoichiometry: 1.0
species: 639810

639810
type: Species
is: http://identifiers.org/pubchem.compound/9848818
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: tauroursodeoxycholate_c

856745
type: Reaction
product: 856829
product: 856841
product: 857046
product: 856961
product: 856913
product: 856937
product: 856805
reactant: 856781
product: 857022
product: 856998
notes: Protein degradation
reactant: 856769
product: 856853
product: 856877
name: r2553
product: 856973
product: 856949
product: 856817
product: 857010
product: 857034
product: 856901
product: 856925
reversible: false
product: 856793
product: 856865
product: 856986
product: 856889
fast: false
reactant: 856757

856829
type: SpeciesReference
stoichiometry: 66.0
species: 625291

856841
type: SpeciesReference
stoichiometry: 22.0
species: 626575

857046
type: SpeciesReference
stoichiometry: 683.0
species: 624727

856961
type: SpeciesReference
stoichiometry: 72.0
species: 626155

856913
type: SpeciesReference
stoichiometry: 10.0
species: 626407

856937
type: SpeciesReference
stoichiometry: 232.0
species: 628075

856805
type: SpeciesReference
stoichiometry: 9.0
species: 627007

856781
type: SpeciesReference
stoichiometry: 683.0
species: 624259

857022
type: SpeciesReference
stoichiometry: 16.0
species: 626695

856998
type: SpeciesReference
stoichiometry: 55.0
species: 628531

856769
type: SpeciesReference
stoichiometry: 683.0
species: 624331

856853
type: SpeciesReference
stoichiometry: 381.0
species: 625627

856877
type: SpeciesReference
stoichiometry: 32.0
species: 630798

856973
type: SpeciesReference
stoichiometry: 52.0
species: 626299

856949
type: SpeciesReference
stoichiometry: 33.0
species: 626251

856817
type: SpeciesReference
stoichiometry: 43.0
species: 625867

857010
type: SpeciesReference
stoichiometry: 5.0
species: 626539

857034
type: SpeciesReference
stoichiometry: 683.0
species: 624655

856901
type: SpeciesReference
stoichiometry: 61.0
species: 627559

856925
type: SpeciesReference
stoichiometry: 41.0
species: 628147

856793
type: SpeciesReference
stoichiometry: 129.0
species: 625675

856865
type: SpeciesReference
stoichiometry: 15.0
species: 627835

856986
type: SpeciesReference
stoichiometry: 42.0
species: 628699

856889
type: SpeciesReference
stoichiometry: 50.0
species: 625819

856757
type: SpeciesReference
stoichiometry: 1.0
species: 640974

640974
type: Species
is: P08123
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CO1A2_c

652274
type: Constraint
message: Warning: Species concentration 3-Oxopropanoate_m is out of the soft bounds.

729367
type: Reaction
product: 729415
reversible: false
is: ENSMUSG00000027957
notes: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
reactant: 729391
reactant: 729379
fast: false
name: r0845
product: 729403

729415
type: SpeciesReference
stoichiometry: 1.0
species: 627211

729391
type: SpeciesReference
stoichiometry: 1.0
species: 627199

729379
type: SpeciesReference
stoichiometry: 1.0
species: 625771

625771
type: Species
constant: false
is: CHEBI:16264
initial amount: NaN
is: C00043
initial concentration: 2.6E-4
boundary condition: true
in compartment: 623911
name: UDP-N-acetylglucosamine_c
has only substance units: false
is: http://identifiers.org/pubchem.compound/3345

729403
type: SpeciesReference
stoichiometry: 1.0
species: 625759

625759
type: Species
is: C00043
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3345
is: CHEBI:16264
constant: false
in compartment: 623923
name: UDP-N-acetylglucosamine_r
initial concentration: 2.6E-4
boundary condition: false
has only substance units: false

649898
type: Constraint
message: Warning: Species concentration Inositol_r is out of the soft bounds.

680483
type: Reaction
is: K01490
reactant: 680507
fast: false
name: r0044
is: ENSMUSG00000005686
reversible: true
is: R00181
reactant: 680495
is: ENSMUSG00000027889
product: 680519
product: 680531
is: ENSMUSG00000070385
notes: AMP aminohydrolase Purine metabolism EC:3.5.4.6

680507
type: SpeciesReference
stoichiometry: 1.0
species: 624259

680495
type: SpeciesReference
stoichiometry: 1.0
species: 625135

680519
type: SpeciesReference
stoichiometry: 1.0
species: 627727

627727
type: Species
initial concentration: 2.6E-4
is: C00130
has only substance units: false
is: http://identifiers.org/cas/131-99-7
name: IMP_c
boundary condition: false
is: http://identifiers.org/pubchem.compound/3430
constant: false
is: CHEBI:17202
in compartment: 623911
initial amount: NaN

680531
type: SpeciesReference
stoichiometry: 1.0
species: 624979

644693
type: Constraint
message: Warning: Species concentration Glutamate_m is out of the soft bounds.

774319
type: Reaction
product: 774343
reactant: 774331
notes: Transport reaction
fast: false
reversible: true
name: r1459

774343
type: SpeciesReference
stoichiometry: 1.0
species: 624955

624955
type: Species
is: C00013
is: http://identifiers.org/pubchem.compound/3315
is: CHEBI:18361
has only substance units: false
initial amount: NaN
boundary condition: false
is: http://identifiers.org/cas/2466-09-3
in compartment: 623875
initial concentration: 1.0E-8
constant: false
name: PPi_n

623875
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: n

774331
type: SpeciesReference
stoichiometry: 1.0
species: 624919

682225
type: Reaction
is: R00239
product: 682261
is: ENSMUSG00000025007
is: K00931
name: r0072
product: 682273
reactant: 682249
fast: false
reactant: 682237
notes: ATP:L-glutamate 5-phosphotransferase Urea cycle and metabolism of amino groups EC:2.7.2.11
is: K12657
reversible: false

682261
type: SpeciesReference
stoichiometry: 1.0
species: 624691

682273
type: SpeciesReference
stoichiometry: 1.0
species: 634171

682249
type: SpeciesReference
stoichiometry: 1.0
species: 625327

625327
type: Species
has only substance units: false
is: C00025
is: http://identifiers.org/pubchem.compound/3327
name: Glutamate_m
is: CHEBI:16015
initial amount: NaN
in compartment: 623863
boundary condition: false
initial concentration: 0.015
constant: false
is: http://identifiers.org/cas/56-86-0

682237
type: SpeciesReference
stoichiometry: 1.0
species: 624367

666324
type: Constraint
message: Error: Species concentration Gentisate_aldehyde_c is out of the hard bounds.

668928
type: Constraint
message: Warning: Species concentration Arachidonyl-CoA_c is out of the soft bounds.

677543
type: Constraint
message: Warning: Species concentration UDP-activated-N-acetyl-D-galactosamine_c is out of the soft bounds.

632623
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Protoporphyrinogen_IX_c

632695
type: Species
boundary condition: false
initial concentration: 2.6E-4
name: Fructose-1P_c
constant: false
is: CHEBI:18105
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4329
is: http://identifiers.org/cas/15978-08-2
has only substance units: false
in compartment: 623911
is: C01094

645449
type: Constraint
message: Error: Species concentration Alanine_m is out of the hard bounds.

682286
type: Reaction
reactant: 682311
fast: false
product: 682336
reactant: 682298
name: r0073
reactant: 682323
reversible: true
is: K00260
product: 682348
is: K00261
notes: L-Glutamate:NAD+ oxidoreductase (deaminating) Glutamate metabolism EC:1.4.1.3 EC:1.4.1.2
product: 682360
is: ENSMUSG00000021794
is: R00243

682311
type: SpeciesReference
stoichiometry: 1.0
species: 624415

682336
type: SpeciesReference
stoichiometry: 1.0
species: 625363

682298
type: SpeciesReference
stoichiometry: 1.0
species: 625327

682323
type: SpeciesReference
stoichiometry: 1.0
species: 624295

682348
type: SpeciesReference
stoichiometry: 1.0
species: 624463

682360
type: SpeciesReference
stoichiometry: 1.0
species: 625003

625003
type: Species
is: http://identifiers.org/cas/7664-41-7
initial amount: NaN
has only substance units: false
is: CHEBI:16134
constant: false
boundary condition: false
name: NH3_m
in compartment: 623863
is: C00014
initial concentration: 5.25E-4
is: http://identifiers.org/pubchem.compound/3316

669288
type: Constraint
message: Warning: Species concentration PS-VLDL-pool_c is out of the soft bounds.

654002
type: Constraint
message: Warning: Species concentration Spermidine_s is out of the soft bounds.

841008
type: Reaction
product: 841032
reactant: 841020
notes: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
name: r2358

841032
type: SpeciesReference
stoichiometry: 1.0
species: 640110

640110
type: Species
in compartment: 623911
is: C04686
is: CHEBI:15546
constant: false
is: http://identifiers.org/cas/35687-86-6
is: http://identifiers.org/pubchem.compound/7267
initial concentration: 2.6E-4
boundary condition: false
has only substance units: false
initial amount: NaN
name: prostaglandin-c1_c

841020
type: SpeciesReference
stoichiometry: 1.0
species: 640122

640122
type: Species
is: C04686
is: http://identifiers.org/cas/35687-86-6
name: prostaglandin-c1_s
is: http://identifiers.org/pubchem.compound/7267
constant: false
initial concentration: 2.6E-4
is: CHEBI:15546
in compartment: 623935
has only substance units: false
initial amount: NaN
boundary condition: false

644070
type: Constraint
message: Warning: Species concentration UDP_r is out of the soft bounds.

790949
type: Reaction
reversible: false
reactant: 790973
product: 791021
is: ENSMUSG00000031904
product: 791009
notes: Y+LAT2 Utilized transport
fast: false
name: r1708
reactant: 790985
product: 790997
reactant: 790961

790973
type: SpeciesReference
stoichiometry: 1.0
species: 626695

791021
type: SpeciesReference
stoichiometry: 1.0
species: 633079

791009
type: SpeciesReference
stoichiometry: 1.0
species: 626707

790985
type: SpeciesReference
stoichiometry: 1.0
species: 633091

790997
type: SpeciesReference
stoichiometry: 1.0
species: 626251

790961
type: SpeciesReference
stoichiometry: 1.0
species: 626263

648854
type: Constraint
message: Error: Species concentration Chloride_c is out of the hard bounds.

677087
type: Constraint
message: Warning: Species concentration Collagen_EMID2_c is out of the soft bounds.

666528
type: Constraint
message: Warning: Species concentration Butyryl-ACP_c is out of the soft bounds.

662677
type: Constraint
message: Error: Species concentration 5-Formyl-THF_m is out of the hard bounds.

799096
type: Reaction
reactant: 799132
fast: false
product: 799168
notes: Y+LAT2 Utilized transport
is: ENSMUSG00000031904
reactant: 799108
name: r1805
product: 799144
reversible: false
reactant: 799120
product: 799156

799132
type: SpeciesReference
stoichiometry: 1.0
species: 633091

799168
type: SpeciesReference
stoichiometry: 1.0
species: 633079

799108
type: SpeciesReference
stoichiometry: 1.0
species: 627019

799144
type: SpeciesReference
stoichiometry: 1.0
species: 627007

799120
type: SpeciesReference
stoichiometry: 1.0
species: 629551

799156
type: SpeciesReference
stoichiometry: 1.0
species: 629563

662629
type: Constraint
message: Error: Species concentration Methacrylyl-CoA_m is out of the hard bounds.

653450
type: Constraint
message: Warning: Species concentration dGTP_s is out of the soft bounds.

637747
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: 2-Lysolecithin-pool_r

646978
type: Constraint
message: Warning: Species concentration PEP_c is out of the soft bounds.

636895
type: Species
boundary condition: true
in compartment: 623935
is: C08320
constant: false
is: http://identifiers.org/pubchem.compound/10518
has only substance units: false
name: Lignocerate_s
is: http://identifiers.org/cas/557-59-5
initial amount: NaN
initial concentration: 2.6E-4
is: CHEBI:28866

845123
type: Reaction
product: 845171
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
fast: false
name: r2419
product: 845159
reversible: true
reactant: 845147
is: ENSMUSG00000025792
reactant: 845135

845171
type: SpeciesReference
stoichiometry: 1.0
species: 624727

845159
type: SpeciesReference
stoichiometry: 1.0
species: 625363

845147
type: SpeciesReference
stoichiometry: 1.0
species: 624763

845135
type: SpeciesReference
stoichiometry: 1.0
species: 625339

751127
type: Reaction
name: r1195
reactant: 751151
is: R02057
notes: CDPethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase Glycerophospholipid metabolism EC:2.7.8.1
reactant: 751139
is: K13644
reversible: false
is: K00993
product: 751163
product: 751175
is: ENSMUSG00000075703
is: ENSMUSG00000040774
fast: false

751151
type: SpeciesReference
stoichiometry: 1.0
species: 631602

631602
type: Species
name: CDP-ethanolamine_c
has only substance units: false
initial concentration: 2.6E-4
constant: false
is: C00570
in compartment: 623911
is: CHEBI:16732
is: http://identifiers.org/pubchem.compound/3849
initial amount: NaN
boundary condition: false

751139
type: SpeciesReference
stoichiometry: 1.0
species: 638262

638262
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1,2-Diacylglycerol-VLDL-PS-pool_c

751163
type: SpeciesReference
stoichiometry: 1.0
species: 638574

638574
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: PE-PS-VLDL-pool_c

751175
type: SpeciesReference
stoichiometry: 1.0
species: 626011

802959
type: Reaction
name: r1851
product: 803007
reversible: false
product: 803031
notes: Y+LAT2 Utilized transport
fast: false
product: 803019
reactant: 802983
is: ENSMUSG00000031904
reactant: 802971
reactant: 802995

803007
type: SpeciesReference
stoichiometry: 1.0
species: 628147

803031
type: SpeciesReference
stoichiometry: 1.0
species: 633079

803019
type: SpeciesReference
stoichiometry: 1.0
species: 630810

802983
type: SpeciesReference
stoichiometry: 1.0
species: 630798

802971
type: SpeciesReference
stoichiometry: 1.0
species: 628159

802995
type: SpeciesReference
stoichiometry: 1.0
species: 633091

654530
type: Constraint
message: Warning: Species concentration 4-Aminobutyrate_m is out of the soft bounds.

638634
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1,2-Diacylglycerol-Bile-PC-pool_c

627067
type: Species
in compartment: 623935
boundary condition: true
constant: false
is: CHEBI:16958
is: C00099
is: http://identifiers.org/cas/107-95-9
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3399
name: beta-Alanine_s

713141
type: Reaction
is: K03783
name: r0569
is: ENSMUSG00000021871
reactant: 713165
reactant: 713153
is: ENSMUSG00000068417
notes: Deoxyinosine:orthophosphate ribosyltransferase Purine metabolism EC:2.4.2.1 EC:2.4.2.4
product: 713177
fast: false
is: R02748
reversible: true
is: K03784
product: 713189

713165
type: SpeciesReference
stoichiometry: 1.0
species: 636007

636007
type: Species
boundary condition: false
has only substance units: false
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7859
name: Deoxyinosine_c
is: C05512
constant: false
is: CHEBI:28997
initial concentration: 2.6E-4

713153
type: SpeciesReference
stoichiometry: 1.0
species: 624727

713177
type: SpeciesReference
stoichiometry: 1.0
species: 629527

629527
type: Species
initial concentration: 2.6E-4
name: Hypoxanthine_c
constant: false
has only substance units: false
is: CHEBI:17368
boundary condition: false
in compartment: 623911
is: C00262
is: http://identifiers.org/cas/68-94-0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3560

713189
type: SpeciesReference
stoichiometry: 1.0
species: 631926

649778
type: Constraint
message: Warning: Species concentration Histidine_s is out of the soft bounds.

635551
type: Species
is: C05337
name: Chenodeoxycholoyl-CoA_c
initial concentration: 2.6E-4
is: CHEBI:28701
constant: false
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/7715
in compartment: 623911
initial amount: NaN

662077
type: Constraint
message: Error: Species concentration (3Z)-Dodecenoyl-CoA_m is out of the hard bounds.

660853
type: Constraint
message: Error: Species concentration Xanthosine_c is out of the hard bounds.

675000
type: Constraint
message: Warning: Species concentration sulfochenodeoxycholate_s is out of the soft bounds.

656438
type: Constraint
message: Error: Species concentration Ribitol_c is out of the hard bounds.

676979
type: Constraint
message: Error: Species concentration Collagen_COPA1_c is out of the hard bounds.

783401
type: Reaction
name: r1597
product: 783449
fast: false
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: 783413
product: 783437
reactant: 783425
is: ENSMUSG00000040010

783449
type: SpeciesReference
stoichiometry: 1.0
species: 626551

783413
type: SpeciesReference
stoichiometry: 1.0
species: 626419

783437
type: SpeciesReference
stoichiometry: 1.0
species: 626407

783425
type: SpeciesReference
stoichiometry: 1.0
species: 626539

821760
type: Reaction
reactant: 821772
name: r2107
product: 821796
is: ENSMUSG00000032902
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
product: 821808
reactant: 821784

821772
type: SpeciesReference
stoichiometry: 1.0
species: 625351

821796
type: SpeciesReference
stoichiometry: 1.0
species: 625339

821808
type: SpeciesReference
stoichiometry: 1.0
species: 632155

821784
type: SpeciesReference
stoichiometry: 1.0
species: 632143

675504
type: Constraint
message: Warning: Species concentration trans,cis-octadeca-2,9-dienoyl-CoA_m is out of the soft bounds.

863875
type: Reaction
product: 864115
product: 864175
product: 863995
product: 864127
product: 863923
product: 863959
fast: false
reactant: 863899
product: 863935
name: r2575
product: 863971
reactant: 863887
product: 864139
product: 864103
product: 864031
product: 864067
product: 863983
notes: Protein degradation
product: 864043
reversible: false
product: 864079
reactant: 863911
product: 864151
product: 863947
product: 864163
product: 864091
product: 864055
product: 864019
product: 864007

864115
type: SpeciesReference
stoichiometry: 67.0
species: 628699

864175
type: SpeciesReference
stoichiometry: 872.5
species: 624727

863995
type: SpeciesReference
stoichiometry: 23.0
species: 627835

864127
type: SpeciesReference
stoichiometry: 67.0
species: 628531

863923
type: SpeciesReference
stoichiometry: 102.0
species: 625675

863959
type: SpeciesReference
stoichiometry: 101.0
species: 625291

863899
type: SpeciesReference
stoichiometry: 872.5
species: 624331

863935
type: SpeciesReference
stoichiometry: 12.0
species: 627007

863971
type: SpeciesReference
stoichiometry: 46.0
species: 626575

863887
type: SpeciesReference
stoichiometry: 1.0
species: 641106

641106
type: Species
is: P25940
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CO5A3_c

864139
type: SpeciesReference
stoichiometry: 8.0
species: 626539

864103
type: SpeciesReference
stoichiometry: 69.0
species: 626299

864031
type: SpeciesReference
stoichiometry: 122.0
species: 627559

864067
type: SpeciesReference
stoichiometry: 290.0
species: 628075

863983
type: SpeciesReference
stoichiometry: 429.0
species: 625627

864043
type: SpeciesReference
stoichiometry: 12.0
species: 626407

864079
type: SpeciesReference
stoichiometry: 78.0
species: 626251

863911
type: SpeciesReference
stoichiometry: 872.5
species: 624259

864151
type: SpeciesReference
stoichiometry: 11.0
species: 626695

863947
type: SpeciesReference
stoichiometry: 76.0
species: 625867

864163
type: SpeciesReference
stoichiometry: 872.5
species: 624655

864091
type: SpeciesReference
stoichiometry: 84.0
species: 626155

864055
type: SpeciesReference
stoichiometry: 24.0
species: 628147

864019
type: SpeciesReference
stoichiometry: 86.0
species: 625819

864007
type: SpeciesReference
stoichiometry: 38.0
species: 630798

814021
type: Reaction
reactant: 814045
fast: false
product: 814093
notes: Y+LAT2 Utilized transport
product: 814069
product: 814081
name: r1982
reversible: false
is: ENSMUSG00000031904
reactant: 814057
reactant: 814033

814045
type: SpeciesReference
stoichiometry: 1.0
species: 633091

814093
type: SpeciesReference
stoichiometry: 1.0
species: 625831

814069
type: SpeciesReference
stoichiometry: 1.0
species: 629551

814081
type: SpeciesReference
stoichiometry: 1.0
species: 633079

814057
type: SpeciesReference
stoichiometry: 1.0
species: 625819

814033
type: SpeciesReference
stoichiometry: 1.0
species: 629563

751187
type: Reaction
product: 751235
reactant: 751199
fast: false
is: R01802
product: 751223
name: r1196
is: ENSMUSG00000030682
reactant: 751211
notes: CDPdiacylglycerol:myo-inositol 3-phosphatidyltransferase Glycerophospholipid metabolism / Phosphatidylinositol signaling system EC:2.7.8.11
is: K00999
reversible: false

751235
type: SpeciesReference
stoichiometry: 1.0
species: 625999

751199
type: SpeciesReference
stoichiometry: 1.0
species: 638538

751223
type: SpeciesReference
stoichiometry: 1.0
species: 637711

637711
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: PI-pool_r

751211
type: SpeciesReference
stoichiometry: 1.0
species: 627907

627907
type: Species
name: Inositol_r
is: http://identifiers.org/pubchem.compound/3437
boundary condition: false
is: http://identifiers.org/cas/87-89-8
has only substance units: false
is: CHEBI:17268
in compartment: 623923
initial concentration: 2.6E-4
initial amount: NaN
constant: false
is: C00137

646181
type: Constraint
message: Warning: Species concentration Formate_s is out of the soft bounds.

649526
type: Constraint
message: Error: Species concentration IMP_c is out of the hard bounds.

846719
type: Reaction
fast: false
product: 846767
notes: Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.4
is: ENSMUSG00000027219
name: r2448
reactant: 846731
product: 846755
reversible: false
reactant: 846743

846767
type: SpeciesReference
stoichiometry: 1.0
species: 633079

846731
type: SpeciesReference
stoichiometry: 1.0
species: 629767

629767
type: Species
is: http://identifiers.org/pubchem.compound/3588
boundary condition: true
initial concentration: 2.6E-4
constant: false
in compartment: 623935
is: CHEBI:17596
name: Inosine_s
initial amount: NaN
has only substance units: false
is: http://identifiers.org/cas/58-63-9
is: C00294

846755
type: SpeciesReference
stoichiometry: 1.0
species: 629755

629755
type: Species
has only substance units: false
is: CHEBI:17596
boundary condition: false
in compartment: 623911
name: Inosine_c
initial amount: NaN
is: http://identifiers.org/cas/58-63-9
is: C00294
is: http://identifiers.org/pubchem.compound/3588
initial concentration: 2.6E-4
constant: false

846743
type: SpeciesReference
stoichiometry: 1.0
species: 633091

633835
type: Species
boundary condition: true
is: C02538
is: http://identifiers.org/pubchem.compound/5545
has only substance units: false
initial concentration: 2.6E-4
name: Estrone_3-sulfate_s
in compartment: 623935
initial amount: NaN
is: CHEBI:17474
constant: false

665425
type: Constraint
message: Warning: Species concentration 3-Ketolactose_s is out of the soft bounds.

662473
type: Constraint
message: Warning: Species concentration Tiglyl-CoA_m is out of the soft bounds.

668232
type: Constraint
message: Warning: Species concentration HDL_s is out of the soft bounds.

652886
type: Constraint
message: Error: Species concentration Palmitate_p is out of the hard bounds.

670284
type: Constraint
message: Error: Species concentration Acyl-CoA-VLDL-PE-pool_c is out of the hard bounds.

842856
type: Reaction
name: r2390
product: 842928
is: ENSMUSG00000003528
product: 842916
reactant: 842868
product: 842904
reactant: 842880
fast: false
reactant: 842892
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true

842928
type: SpeciesReference
stoichiometry: 1.0
species: 625747

842916
type: SpeciesReference
stoichiometry: 1.0
species: 626623

842868
type: SpeciesReference
stoichiometry: 1.0
species: 630906

842904
type: SpeciesReference
stoichiometry: 1.0
species: 630894

842880
type: SpeciesReference
stoichiometry: 1.0
species: 626647

842892
type: SpeciesReference
stoichiometry: 1.0
species: 625723

695501
type: Reaction
is: K05604
is: K01270
reactant: 695513
reversible: false
product: 695549
fast: false
is: ENSMUSG00000056162
is: R01166
product: 695537
notes: Nalpha-(beta-alanyl)-L-histidine hydrolase Alanine and aspartate metabolism / Histidine metabolism / beta-Alanine metabolism EC:3.4.13.3
name: r0284
reactant: 695525

695513
type: SpeciesReference
stoichiometry: 1.0
species: 630691

630691
type: Species
has only substance units: false
boundary condition: false
in compartment: 623911
constant: false
is: C00386
initial amount: NaN
is: CHEBI:15727
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3676
name: Carnosine_c
is: http://identifiers.org/cas/305-84-0

695549
type: SpeciesReference
stoichiometry: 1.0
species: 627835

695537
type: SpeciesReference
stoichiometry: 1.0
species: 627055

627055
type: Species
is: http://identifiers.org/pubchem.compound/3399
initial concentration: 2.6E-4
is: http://identifiers.org/cas/107-95-9
name: beta-Alanine_c
has only substance units: false
boundary condition: false
is: C00099
initial amount: NaN
in compartment: 623911
constant: false
is: CHEBI:16958

695525
type: SpeciesReference
stoichiometry: 1.0
species: 624259

769352
type: Reaction
fast: false
reversible: true
is: R06983
is: K00121
product: 769388
reactant: 769376
name: r1378
notes: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
is: ENSMUSG00000028138
product: 769400
reactant: 769364

769388
type: SpeciesReference
stoichiometry: 1.0
species: 624451

769376
type: SpeciesReference
stoichiometry: 1.0
species: 624403

769400
type: SpeciesReference
stoichiometry: 1.0
species: 639114

639114
type: Species
is: CHEBI:16225
name: Formylglutathione_c
has only substance units: false
is: C01031
boundary condition: false
in compartment: 623911
constant: false
initial amount: NaN
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/4274

769364
type: SpeciesReference
stoichiometry: 1.0
species: 639102

639102
type: Species
has only substance units: false
in compartment: 623911
is: http://identifiers.org/pubchem.compound/7846992
initial amount: NaN
is: C14180
initial concentration: 2.6E-4
is: http://identifiers.org/cas/32260-87-0
boundary condition: false
constant: false
is: CHEBI:48926
name: Hydroxymethylglutathione_c

708954
type: Reaction
is: K00106
reactant: 708990
is: R02103
fast: false
reactant: 708978
product: 709014
product: 709002
is: ENSMUSG00000024066
is: K11177
reactant: 708966
is: K11178
is: K13480
name: r0502
is: K13479
is: K13482
is: K13481
is: K00087
is: K13483
notes: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true

708990
type: SpeciesReference
stoichiometry: 1.0
species: 624259

708978
type: SpeciesReference
stoichiometry: 1.0
species: 624403

709014
type: SpeciesReference
stoichiometry: 1.0
species: 630571

630571
type: Species
is: http://identifiers.org/cas/69-93-2
boundary condition: false
initial amount: NaN
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3657
name: Urate_c
in compartment: 623911
has only substance units: false
is: CHEBI:17775
is: C00366
constant: false

709002
type: SpeciesReference
stoichiometry: 1.0
species: 624451

708966
type: SpeciesReference
stoichiometry: 1.0
species: 630667

630667
type: Species
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
in compartment: 623911
is: http://identifiers.org/pubchem.compound/3675
initial amount: NaN
is: CHEBI:17712
name: Xanthine_c
is: C00385
constant: false
is: http://identifiers.org/cas/69-89-6

836437
type: Reaction
reversible: true
product: 836497
product: 836509
reactant: 836473
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: 836461
is: ENSMUSG00000030236
product: 836485
fast: false
name: r2291
reactant: 836449

836497
type: SpeciesReference
stoichiometry: 1.0
species: 629731

836509
type: SpeciesReference
stoichiometry: 1.0
species: 639966

836473
type: SpeciesReference
stoichiometry: 1.0
species: 639954

836461
type: SpeciesReference
stoichiometry: 1.0
species: 629719

836485
type: SpeciesReference
stoichiometry: 1.0
species: 640302

836449
type: SpeciesReference
stoichiometry: 1.0
species: 640314

646277
type: Constraint
message: Warning: Species concentration Sulfate_s is out of the soft bounds.

657614
type: Constraint
message: Error: Species concentration Isobutyryl-CoA_m is out of the hard bounds.

679715
type: Reaction
reversible: true
is: K00859
product: 679751
is: K02318
reactant: 679727
is: R00130
notes: ATP:dephospho-CoA 3'-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
reactant: 679739
name: r0032
is: ENSMUSG00000001755
fast: false
product: 679763

679751
type: SpeciesReference
stoichiometry: 1.0
species: 624655

679727
type: SpeciesReference
stoichiometry: 1.0
species: 624331

679739
type: SpeciesReference
stoichiometry: 1.0
species: 632335

632335
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:15468
constant: false
name: Dephospho-CoA_c
initial concentration: 2.6E-4
in compartment: 623911
is: C00882
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4138

679763
type: SpeciesReference
stoichiometry: 1.0
species: 624799

652478
type: Constraint
message: Error: Species concentration 1,3DPG_c is out of the hard bounds.

632563
type: Species
boundary condition: false
name: 2-Methylbutyryl-CoA_m
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/4276
is: C01033
is: CHEBI:15477
has only substance units: false
in compartment: 623863
initial amount: NaN
constant: false

649922
type: Constraint
message: Warning: Species concentration Inositol_c is out of the soft bounds.

674892
type: Constraint
message: Error: Species concentration prostaglandin-h2_s is out of the hard bounds.

643842
type: Constraint
message: Error: Species concentration PPi_r is out of the hard bounds.

676307
type: Constraint
message: Error: Species concentration Collagen_CO6A1_c is out of the hard bounds.

673296
type: Constraint
message: Warning: Species concentration leukotriene-b4_s is out of the soft bounds.

649226
type: Constraint
message: Warning: Species concentration Leucine_s is out of the soft bounds.

656318
type: Constraint
message: Error: Species concentration dTTP_s is out of the hard bounds.

730507
type: Reaction
fast: false
product: 730543
reactant: 730519
reactant: 730531
reversible: false
notes: MCT 2 Active transport
is: ENSMUSG00000020102
product: 730555
name: r0872

730543
type: SpeciesReference
stoichiometry: 1.0
species: 625219

625219
type: Species
initial amount: NaN
is: CHEBI:32816
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
boundary condition: false
is: C00022
constant: false
in compartment: 623863
name: Pyruvate_m
is: http://identifiers.org/cas/127-17-3
initial concentration: 0.00155

730519
type: SpeciesReference
stoichiometry: 1.0
species: 625195

730531
type: SpeciesReference
stoichiometry: 1.0
species: 626623

730555
type: SpeciesReference
stoichiometry: 1.0
species: 626647

676859
type: Constraint
message: Error: Species concentration Collagen_COLA1_c is out of the hard bounds.

676595
type: Constraint
message: Error: Species concentration Collagen_COBA1_c is out of the hard bounds.

658945
type: Constraint
message: Warning: Species concentration 2-Oxoglutaramate_m is out of the soft bounds.

678683
type: Reaction
product: 678719
fast: false
reactant: 678695
reversible: false
is: ENSMUSG00000028393
name: r0015
product: 678707
notes: 5-Aminolevulinate hydro-lyase(adding 5-aminolevulinate and cyclizing) Porphyrin and chlorophyll metabolism EC:4.2.1.24
is: K01698
is: R00036

678719
type: SpeciesReference
stoichiometry: 2.0
species: 624259

678695
type: SpeciesReference
stoichiometry: 2.0
species: 630954

630954
type: Species
is: CHEBI:17549
initial concentration: 2.6E-4
name: 5-Aminolevulinate_c
has only substance units: false
boundary condition: false
is: http://identifiers.org/cas/106-60-5
is: http://identifiers.org/pubchem.compound/3719
in compartment: 623911
initial amount: NaN
is: C00430
constant: false

678707
type: SpeciesReference
stoichiometry: 1.0
species: 632407

632407
type: Species
in compartment: 623911
name: Porphobilinogen_c
is: http://identifiers.org/cas/487-90-1
is: C00931
initial amount: NaN
is: CHEBI:17381
initial concentration: 2.6E-4
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/4184
constant: false

693041
type: Reaction
is: ENSMUSG00000023456
reversible: true
name: r0243
fast: false
reactant: 693053
notes: D-Glyceraldehyde-3-phosphate ketol-isomerase Glycolysis / Gluconeogenesis EC:5.3.1.1
is: R01015
is: K01803
product: 693065

693053
type: SpeciesReference
stoichiometry: 1.0
species: 627475

693065
type: SpeciesReference
stoichiometry: 1.0
species: 627295

670536
type: Constraint
message: Warning: Species concentration 1,2-Diacylglycerol-VLDL-TG-pool_c is out of the soft bounds.

699112
type: Reaction
product: 699148
reactant: 699124
is: ENSMUSG00000028961
notes: 6-Phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating) Pentose phosphate pathway EC:1.1.1.44
is: R01528
product: 699172
product: 699160
fast: false
reactant: 699136
reversible: true
is: K00033
name: r0343

699148
type: SpeciesReference
stoichiometry: 1.0
species: 624499

699124
type: SpeciesReference
stoichiometry: 1.0
species: 630295

699172
type: SpeciesReference
stoichiometry: 1.0
species: 628831

628831
type: Species
is: CHEBI:17363
has only substance units: false
initial amount: NaN
in compartment: 623911
name: Ribulose-5P_c
is: http://identifiers.org/cas/4151-19-3
is: http://identifiers.org/pubchem.compound/3499
is: C00199
constant: false
initial concentration: 2.6E-4
boundary condition: false

699160
type: SpeciesReference
stoichiometry: 1.0
species: 624859

699136
type: SpeciesReference
stoichiometry: 1.0
species: 624547

655802
type: Constraint
message: Warning: Species concentration Stearoyl-CoA_c is out of the soft bounds.

653654
type: Constraint
message: Error: Species concentration Orotate_s is out of the hard bounds.

656978
type: Constraint
message: Warning: Species concentration Pyridoxamine_c is out of the soft bounds.

627715
type: Species
initial concentration: 2.6E-4
in compartment: 623899
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3429
name: Isopentenyl-PP_p
is: C00129
is: CHEBI:16584
boundary condition: false
constant: false
is: http://identifiers.org/cas/358-71-4

643410
type: Constraint
message: Error: Species concentration ADP_m is out of the hard bounds.

803547
type: Reaction
reactant: 803560
reactant: 803573
notes: Y+LAT2 Utilized transport
product: 803612
fast: false
is: ENSMUSG00000031904
reversible: false
reactant: 803586
name: r1858
product: 803625
product: 803599

803560
type: SpeciesReference
stoichiometry: 1.0
species: 628543

803573
type: SpeciesReference
stoichiometry: 1.0
species: 626575

803612
type: SpeciesReference
stoichiometry: 1.0
species: 626587

803586
type: SpeciesReference
stoichiometry: 1.0
species: 633091

803625
type: SpeciesReference
stoichiometry: 1.0
species: 633079

803599
type: SpeciesReference
stoichiometry: 1.0
species: 628531

781062
type: Reaction
is: ENSMUSG00000040010
product: 781110
name: r1558
reversible: true
reactant: 781074
product: 781098
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: 781086
fast: false

781110
type: SpeciesReference
stoichiometry: 1.0
species: 626263

781074
type: SpeciesReference
stoichiometry: 1.0
species: 625687

781098
type: SpeciesReference
stoichiometry: 1.0
species: 625675

781086
type: SpeciesReference
stoichiometry: 1.0
species: 626251

631158
type: Species
boundary condition: false
in compartment: 623911
is: C00469
constant: false
has only substance units: false
is: http://identifiers.org/cas/64-17-5
initial concentration: 2.6E-4
name: Ethanol_c
is: CHEBI:16236
is: http://identifiers.org/pubchem.compound/3752
initial amount: NaN

651578
type: Constraint
message: Warning: Species concentration Ethanolamine_c is out of the soft bounds.

649490
type: Constraint
message: Warning: Species concentration CMP-N-acetylneuraminate_n is out of the soft bounds.

698092
type: Reaction
name: r0326
fast: false
notes: UDP-D-glucuronate carboxy-lyase Starch and sucrose metabolism / Nucleotide sugars metabolism EC:4.1.1.35
is: K08678
is: K12449
product: 698128
reactant: 698104
is: ENSMUSG00000057363
product: 698116
reversible: false
is: R01384

698128
type: SpeciesReference
stoichiometry: 1.0
species: 624835

624835
type: Species
initial amount: NaN
is: CHEBI:16526
in compartment: 623923
name: CO2_r
initial concentration: 0.025
is: http://identifiers.org/pubchem.compound/3313
has only substance units: false
boundary condition: false
is: C00011
is: http://identifiers.org/cas/124-38-9
constant: false

698104
type: SpeciesReference
stoichiometry: 1.0
species: 628411

628411
type: Species
name: UDP-glucuronate_r
is: http://identifiers.org/pubchem.compound/3467
is: C00167
initial concentration: 2.6E-4
has only substance units: false
is: CHEBI:17200
initial amount: NaN
boundary condition: false
in compartment: 623923
constant: false

698116
type: SpeciesReference
stoichiometry: 1.0
species: 628759

628759
type: Species
boundary condition: false
name: UDP-xylose_r
constant: false
in compartment: 623923
initial amount: NaN
is: C00190
is: http://identifiers.org/pubchem.compound/3490
is: CHEBI:16082
has only substance units: false
initial concentration: 2.6E-4

676991
type: Constraint
message: Warning: Species concentration Collagen_COPA1_c is out of the soft bounds.

773815
type: Reaction
name: r1450
notes: EC:1.3.3.6
product: 773863
is: ENSMUSG00000020777
reactant: 773827
reversible: false
reactant: 773839
product: 773851
fast: false
is: ENSMUSG00000029098

773863
type: SpeciesReference
stoichiometry: 1.0
species: 630774

773827
type: SpeciesReference
stoichiometry: 1.0
species: 630786

773839
type: SpeciesReference
stoichiometry: 1.0
species: 635383

773851
type: SpeciesReference
stoichiometry: 1.0
species: 635395

635395
type: Species
is: http://identifiers.org/pubchem.compound/7658
initial amount: NaN
is: C05271
initial concentration: 1.0E-5
constant: false
is: CHEBI:28706
in compartment: 623863
boundary condition: false
has only substance units: false
name: (2E)-Hexenoyl-CoA_m

636367
type: Species
is: C05757
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/8052
in compartment: 623911
initial amount: NaN
initial concentration: 2.6E-4
name: D-3-Hydroxydodecanoyl-ACP_c
constant: false

675204
type: Constraint
message: Error: Species concentration 3-oxomyrist-7-enoyl-CoA_m is out of the hard bounds.

646679
type: Constraint
message: Error: Species concentration Serine_l is out of the hard bounds.

650858
type: Constraint
message: Warning: Species concentration Acetoacetate_s is out of the soft bounds.

641406
type: Species
is: Q9Y215
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_COLQ_c

692081
type: Reaction
fast: false
is: R00943
name: r0228
is: ENSMUSG00000021048
reactant: 692093
product: 692141
reactant: 692105
is: K13402
is: K01938
product: 692153
reversible: false
product: 692129
is: K00288
notes: Formate:tetrahydrofolate ligase (ADP-forming) Glyoxylate and dicarboxylate metabolism / One carbon pool by folate EC:6.3.4.3
reactant: 692117

692093
type: SpeciesReference
stoichiometry: 1.0
species: 627127

627127
type: Species
initial concentration: 2.6E-4
boundary condition: true
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3401
in compartment: 623911
constant: false
is: CHEBI:15635
name: THF_c
has only substance units: false
is: C00101
is: http://identifiers.org/cas/135-16-0

692141
type: SpeciesReference
stoichiometry: 1.0
species: 624727

692105
type: SpeciesReference
stoichiometry: 1.0
species: 626059

692153
type: SpeciesReference
stoichiometry: 1.0
species: 629167

629167
type: Species
initial amount: NaN
initial concentration: 2.6E-4
constant: false
in compartment: 623911
is: C00234
is: http://identifiers.org/pubchem.compound/3533
is: CHEBI:15637
boundary condition: true
name: 10-Formyl-THF_c
has only substance units: false

692129
type: SpeciesReference
stoichiometry: 1.0
species: 624655

692117
type: SpeciesReference
stoichiometry: 1.0
species: 624331

652598
type: Constraint
message: Error: Species concentration Guanine_s is out of the hard bounds.

810157
type: Reaction
product: 810229
notes: Y+LAT2 Utilized transport
reactant: 810169
product: 810205
name: r1936
reactant: 810193
product: 810217
reactant: 810181
reversible: false
fast: false
is: ENSMUSG00000031904

810229
type: SpeciesReference
stoichiometry: 1.0
species: 630079

810169
type: SpeciesReference
stoichiometry: 1.0
species: 626419

810205
type: SpeciesReference
stoichiometry: 1.0
species: 626407

810193
type: SpeciesReference
stoichiometry: 1.0
species: 630067

810217
type: SpeciesReference
stoichiometry: 1.0
species: 633079

810181
type: SpeciesReference
stoichiometry: 1.0
species: 633091

695933
type: Reaction
name: r0292
product: 695981
is: R01218
fast: false
reactant: 695957
reversible: true
is: ENSMUSG00000005667
is: K13403
notes: 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.15
product: 695969
is: K00295
reactant: 695945

695981
type: SpeciesReference
stoichiometry: 1.0
species: 624463

695957
type: SpeciesReference
stoichiometry: 1.0
species: 624415

695969
type: SpeciesReference
stoichiometry: 1.0
species: 631026

631026
type: Species
in compartment: 623863
has only substance units: false
boundary condition: false
is: CHEBI:15638
name: 5,10-Methenyl-THF_m
is: C00445
initial concentration: 2.6E-4
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3733

695945
type: SpeciesReference
stoichiometry: 1.0
species: 628003

628003
type: Species
initial concentration: 2.6E-4
has only substance units: false
is: C00143
boundary condition: false
is: http://identifiers.org/pubchem.compound/3443
is: CHEBI:1989
constant: false
name: 5,10-Methylene-THF_m
is: http://identifiers.org/cas/3432-99-3
initial amount: NaN
in compartment: 623863

822780
type: Reaction
name: r2124
product: 822816
is: ENSMUSG00000032902
reactant: 822792
reactant: 822804
fast: false
product: 822828
reversible: true
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1

822816
type: SpeciesReference
stoichiometry: 1.0
species: 628339

822792
type: SpeciesReference
stoichiometry: 1.0
species: 628351

822804
type: SpeciesReference
stoichiometry: 1.0
species: 632659

822828
type: SpeciesReference
stoichiometry: 1.0
species: 632671

632671
type: Species
in compartment: 623935
initial amount: NaN
is: C01089
is: http://identifiers.org/pubchem.compound/4324
has only substance units: false
constant: false
initial concentration: 2.6E-4
name: (R)-3-Hydroxybutanoate_s
boundary condition: true
is: CHEBI:10983

836353
type: Reaction
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
name: r2290
is: ENSMUSG00000030236
reversible: true
reactant: 836377
reactant: 836389
product: 836425
fast: false
reactant: 836365
product: 836401
product: 836413

836377
type: SpeciesReference
stoichiometry: 1.0
species: 629719

836389
type: SpeciesReference
stoichiometry: 1.0
species: 639918

836425
type: SpeciesReference
stoichiometry: 1.0
species: 639930

836365
type: SpeciesReference
stoichiometry: 1.0
species: 640314

836401
type: SpeciesReference
stoichiometry: 1.0
species: 640302

836413
type: SpeciesReference
stoichiometry: 1.0
species: 629731

840936
type: Reaction
product: 840960
reactant: 840948
notes: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
name: r2356

840960
type: SpeciesReference
stoichiometry: 1.0
species: 640062

840948
type: SpeciesReference
stoichiometry: 1.0
species: 640074

633775
type: Species
in compartment: 623923
constant: false
initial concentration: 2.6E-4
is: CHEBI:16755
is: http://identifiers.org/cas/474-25-9
has only substance units: false
name: Chenodiol_r
boundary condition: false
initial amount: NaN
is: C02528
is: http://identifiers.org/pubchem.compound/5536

735006
type: Reaction
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.201.2
fast: false
reactant: 735042
reactant: 735030
product: 735066
reversible: false
is: ENSMUSG00000027048
product: 735078
name: r0969
reactant: 735018
product: 735054

735042
type: SpeciesReference
stoichiometry: 2.0
species: 624259

735030
type: SpeciesReference
stoichiometry: 2.0
species: 624331

735066
type: SpeciesReference
stoichiometry: 2.0
species: 624655

735078
type: SpeciesReference
stoichiometry: 2.0
species: 624727

735018
type: SpeciesReference
stoichiometry: 1.0
species: 631986

631986
type: Species
constant: false
name: Cholate_c
initial amount: NaN
has only substance units: false
boundary condition: false
is: C00695
in compartment: 623911
is: http://identifiers.org/pubchem.compound/3963
initial concentration: 2.6E-4
is: CHEBI:16359
is: http://identifiers.org/cas/81-25-4

735054
type: SpeciesReference
stoichiometry: 1.0
species: 631974

631974
type: Species
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3963
is: C00695
is: CHEBI:16359
boundary condition: true
name: Cholate_b
constant: false
is: http://identifiers.org/cas/81-25-4
in compartment: 623887
has only substance units: false
initial amount: NaN

699820
type: Reaction
is: ENSMUSG00000000628
is: ENSMUSG00000025877
reactant: 699832
reactant: 699844
fast: false
reversible: false
notes: Glycolysis / Glyconeogenesis EC:2.7.1.1
product: 699856
name: r0355
product: 699868
is: ENSMUSG00000037012

699832
type: SpeciesReference
stoichiometry: 1.0
species: 625483

625483
type: Species
is: C00031
is: CHEBI:4167
initial amount: NaN
has only substance units: false
boundary condition: false
in compartment: 623911
name: Glucose_c
constant: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/50-99-7
is: http://identifiers.org/pubchem.compound/3333

699844
type: SpeciesReference
stoichiometry: 1.0
species: 627751

627751
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/3431
in compartment: 623911
constant: false
is: C00131
boundary condition: true
is: CHEBI:16284
name: dATP_c
initial amount: NaN
initial concentration: 2.6E-4
is: http://identifiers.org/cas/1927-31-7

699856
type: SpeciesReference
stoichiometry: 1.0
species: 626899

699868
type: SpeciesReference
stoichiometry: 1.0
species: 628855

628855
type: Species
is: CHEBI:16174
in compartment: 623911
initial concentration: 2.6E-4
boundary condition: false
name: dADP_c
is: http://identifiers.org/pubchem.compound/3506
initial amount: NaN
is: C00206
constant: false
has only substance units: false

629851
type: Species
in compartment: 623923
initial concentration: 2.6E-4
constant: false
is: CHEBI:16436
is: http://identifiers.org/pubchem.compound/3601
boundary condition: false
initial amount: NaN
is: http://identifiers.org/cas/987-78-0
name: CDP-choline_r
is: C00307
has only substance units: false

725864
type: Reaction
is: ENSMUSG00000041426
product: 725900
notes: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
fast: false
reversible: false
reactant: 725888
product: 725912
name: r0779
is: R03352
reactant: 725876

725900
type: SpeciesReference
stoichiometry: 1.0
species: 632923

632923
type: Species
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/4414
is: CHEBI:11805
is: C01188
initial amount: NaN
initial concentration: 2.6E-4
is: http://identifiers.org/cas/2068-83-9
name: 3-Hydroxyisobutyrate_m
in compartment: 623863
constant: false

725888
type: SpeciesReference
stoichiometry: 1.0
species: 624295

725912
type: SpeciesReference
stoichiometry: 1.0
species: 624811

725876
type: SpeciesReference
stoichiometry: 1.0
species: 634519

634519
type: Species
name: 3-Hydroxyisobutyryl-CoA_m
in compartment: 623863
is: C04047
is: http://identifiers.org/pubchem.compound/6748
is: CHEBI:15481
initial concentration: 2.6E-4
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

821820
type: Reaction
reactant: 821844
reversible: true
fast: false
is: ENSMUSG00000032902
product: 821856
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
name: r2108
reactant: 821832
product: 821868

821844
type: SpeciesReference
stoichiometry: 1.0
species: 632659

821856
type: SpeciesReference
stoichiometry: 1.0
species: 625339

821832
type: SpeciesReference
stoichiometry: 1.0
species: 625351

821868
type: SpeciesReference
stoichiometry: 1.0
species: 632671

652754
type: Constraint
message: Warning: Species concentration Butyrate_s is out of the soft bounds.

627691
type: Species
is: CHEBI:16556
is: http://identifiers.org/pubchem.compound/3428
boundary condition: true
is: http://identifiers.org/cas/3063-71-6
initial concentration: 2.6E-4
in compartment: 623911
initial amount: NaN
constant: false
has only substance units: false
name: CMP-N-acetylneuraminate_c
is: C00128

652346
type: Constraint
message: Warning: Species concentration D-Xylulose-5P_c is out of the soft bounds.

625699
type: Species
initial concentration: 2.6E-4
has only substance units: false
name: Alanine_l
initial amount: NaN
is: http://identifiers.org/cas/56-41-7
is: C00041
in compartment: 623851
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3343
is: CHEBI:16977

663457
type: Constraint
message: Warning: Species concentration (S)-3-Hydroxy-2-methylbutyryl-CoA_m is out of the soft bounds.

802287
type: Reaction
product: 802359
reactant: 802299
fast: false
reversible: false
notes: Y+LAT2 Utilized transport
reactant: 802311
name: r1843
is: ENSMUSG00000031904
product: 802335
product: 802347
reactant: 802323

802359
type: SpeciesReference
stoichiometry: 1.0
species: 633079

802299
type: SpeciesReference
stoichiometry: 1.0
species: 628159

802311
type: SpeciesReference
stoichiometry: 1.0
species: 626575

802335
type: SpeciesReference
stoichiometry: 1.0
species: 628147

802347
type: SpeciesReference
stoichiometry: 1.0
species: 626587

802323
type: SpeciesReference
stoichiometry: 1.0
species: 633091

733855
type: Reaction
product: 733879
reactant: 733867
notes: Free diffusion
fast: false
reversible: true
name: r0941

733879
type: SpeciesReference
stoichiometry: 1.0
species: 629743

629743
type: Species
initial amount: NaN
constant: false
is: C00288
initial concentration: 0.0026
boundary condition: false
is: http://identifiers.org/pubchem.compound/3583
name: HCO3-_m
in compartment: 623863
is: CHEBI:17544
has only substance units: false

733867
type: SpeciesReference
stoichiometry: 1.0
species: 629719

633571
type: Species
boundary condition: false
initial concentration: 2.6E-4
has only substance units: false
initial amount: NaN
in compartment: 623887
name: Acetylcholine_b
is: http://identifiers.org/cas/51-84-3
constant: false
is: CHEBI:15355
is: http://identifiers.org/pubchem.compound/5093
is: C01996

680231
type: Reaction
is: K01513
reversible: false
reactant: 680255
name: r0040
is: R00160
fast: false
product: 680279
reactant: 680243
is: ENSMUSG00000037370
notes: FAD nucleotidohydrolase Riboflavin metabolism EC:3.6.1.9 EC:3.6.1.18
product: 680267
is: ENSMUSG00000019989

680255
type: SpeciesReference
stoichiometry: 1.0
species: 624259

680279
type: SpeciesReference
stoichiometry: 1.0
species: 626143

626143
type: Species
in compartment: 623911
is: CHEBI:17621
is: http://identifiers.org/cas/146-17-8
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3361
name: FMN_c
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: C00061

680243
type: SpeciesReference
stoichiometry: 1.0
species: 625051

680267
type: SpeciesReference
stoichiometry: 1.0
species: 625135

667284
type: Constraint
message: Error: Species concentration LTD4_s is out of the hard bounds.

655922
type: Constraint
message: Warning: Species concentration (R)-Mevalonate_c is out of the soft bounds.

667944
type: Constraint
message: Warning: Species concentration Phosphodimethylethanolamine_c is out of the soft bounds.

792797
type: Reaction
name: r1730
fast: false
product: 792845
reactant: 792833
reactant: 792809
is: ENSMUSG00000031904
reversible: false
reactant: 792821
notes: Y+LAT2 Utilized transport
product: 792869
product: 792857

792845
type: SpeciesReference
stoichiometry: 1.0
species: 626299

792833
type: SpeciesReference
stoichiometry: 1.0
species: 633091

792809
type: SpeciesReference
stoichiometry: 1.0
species: 626311

792821
type: SpeciesReference
stoichiometry: 1.0
species: 629551

792869
type: SpeciesReference
stoichiometry: 1.0
species: 633079

792857
type: SpeciesReference
stoichiometry: 1.0
species: 629563

675768
type: Constraint
message: Warning: Species concentration trans,cis-hexadeca-2,9-dienoyl-CoA_m is out of the soft bounds.

713417
type: Reaction
reversible: true
is: ENSMUSG00000071708
is: K00802
is: ENSMUSG00000006442
fast: false
product: 713453
is: K00797
name: r0574
reactant: 713429
reactant: 713441
notes: S-Adenosylmethioninamine:putrescine 3-aminopropyltransferase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:2.5.1.22
product: 713465
is: R02869

713453
type: SpeciesReference
stoichiometry: 1.0
species: 628471

713429
type: SpeciesReference
stoichiometry: 1.0
species: 632791

713441
type: SpeciesReference
stoichiometry: 1.0
species: 629947

713465
type: SpeciesReference
stoichiometry: 1.0
species: 632107

632107
type: Species
is: CHEBI:15746
name: Spermine_c
constant: false
is: C00750
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4012
has only substance units: false
initial concentration: 2.6E-4
in compartment: 623911
boundary condition: false
is: http://identifiers.org/cas/71-44-3

656282
type: Constraint
message: Warning: Species concentration dCTP_c is out of the soft bounds.

827891
type: Reaction
fast: false
is: ENSMUSG00000079262
reactant: 827927
product: 827951
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000041698
product: 827939
name: r2190
product: 827963
reactant: 827915
is: ENSMUSG00000063975
reactant: 827903
reversible: true
is: ENSMUSG00000030237

827927
type: SpeciesReference
stoichiometry: 1.0
species: 639918

827951
type: SpeciesReference
stoichiometry: 1.0
species: 629731

827939
type: SpeciesReference
stoichiometry: 1.0
species: 640446

640446
type: Species
is: http://identifiers.org/pubchem.compound/21252312
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: sulfochenodeoxycholate_c

827963
type: SpeciesReference
stoichiometry: 1.0
species: 639930

827915
type: SpeciesReference
stoichiometry: 1.0
species: 629719

827903
type: SpeciesReference
stoichiometry: 1.0
species: 640458

640458
type: Species
is: http://identifiers.org/pubchem.compound/21252312
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623935
name: sulfochenodeoxycholate_s

671160
type: Constraint
message: Warning: Species concentration CDP-diacylglycerol-VLDL-PI-pool_r is out of the soft bounds.

658813
type: Constraint
message: Error: Species concentration Acrylyl-CoA_m is out of the hard bounds.

648974
type: Constraint
message: Error: Species concentration Ribose-5P_r is out of the hard bounds.

715013
type: Reaction
product: 715085
reactant: 715049
product: 715061
fast: false
reversible: true
notes: (S)-3-methyl-2-oxopentanoate:NAD+ 2-oxidoreductase (CoA-methylbutanoylating) Valine, leucine and isoleucine degradation EC:1.2.1.25
is: R03171
reactant: 715037
name: r0601
reactant: 715025
product: 715073

715085
type: SpeciesReference
stoichiometry: 1.0
species: 624463

715049
type: SpeciesReference
stoichiometry: 1.0
species: 624415

715061
type: SpeciesReference
stoichiometry: 1.0
species: 633991

633991
type: Species
initial amount: NaN
constant: false
in compartment: 623863
has only substance units: false
boundary condition: false
is: CHEBI:15487
is: C02939
initial concentration: 2.6E-4
name: Isovaleryl-CoA_m
is: http://identifiers.org/pubchem.compound/5858

715037
type: SpeciesReference
stoichiometry: 1.0
species: 624811

715025
type: SpeciesReference
stoichiometry: 1.0
species: 629155

629155
type: Species
is: C00233
constant: false
is: CHEBI:48430
is: http://identifiers.org/pubchem.compound/3532
initial amount: NaN
has only substance units: false
initial concentration: 2.6E-4
boundary condition: false
in compartment: 623863
name: 4-Methyl-2-oxopentanoate_m

715073
type: SpeciesReference
stoichiometry: 1.0
species: 624883

670608
type: Constraint
message: Warning: Species concentration 1,2-Diacylglycerol-VLDL-PS-pool_c is out of the soft bounds.

676799
type: Constraint
message: Warning: Species concentration Collagen_COIA1_c is out of the soft bounds.

667032
type: Constraint
message: Warning: Species concentration CoproporphyrinogenI_s is out of the soft bounds.

666648
type: Constraint
message: Warning: Species concentration 3-Oxooctanoyl-ACP_c is out of the soft bounds.

651122
type: Constraint
message: Warning: Species concentration Agmatine_m is out of the soft bounds.

662749
type: Constraint
message: Error: Species concentration 4-Imidazolone-5-propanoate_c is out of the hard bounds.

653522
type: Constraint
message: Warning: Species concentration HCO3-_c is out of the soft bounds.

626731
type: Species
is: http://identifiers.org/pubchem.compound/3382
name: Tyrosine_m
is: http://identifiers.org/cas/60-18-4
initial concentration: 2.6E-4
is: C00082
boundary condition: false
in compartment: 623863
constant: false
is: CHEBI:17895
initial amount: NaN
has only substance units: false

775543
type: Reaction
reversible: true
is: ENSMUSG00000036880
notes: EC:2.3.1.16
fast: false
reactant: 775567
name: r1480
is: ENSMUSG00000059447
product: 775579
reactant: 775555
product: 775591

775567
type: SpeciesReference
stoichiometry: 1.0
species: 640626

640626
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: 3-oxopalmitoleoyl-CoA_m

775579
type: SpeciesReference
stoichiometry: 1.0
species: 625267

775555
type: SpeciesReference
stoichiometry: 1.0
species: 624811

775591
type: SpeciesReference
stoichiometry: 1.0
species: 640578

640578
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: cis-myrist-7-enoyl-CoA_m

636127
type: Species
is: CHEBI:28508
constant: false
initial amount: NaN
name: Gentisate_aldehyde_c
boundary condition: true
has only substance units: false
is: http://identifiers.org/pubchem.compound/70949
in compartment: 623911
initial concentration: 2.6E-4

679019
type: Reaction
product: 679043
is: ENSMUSG00000005580
is: R00089
is: ENSMUSG00000022220
name: r0020
is: K08044
reversible: false
is: ENSMUSG00000022840
is: K08043
is: K01768
is: K05851
is: K08049
is: ENSMUSG00000022376
fast: false
is: K11265
product: 679055
is: K05873
is: K08042
is: K11029
reactant: 679031
notes: ATP pyrophosphate-lyase (cyclizing) Purine metabolism EC:4.6.1.1
is: K08048
is: K08041
is: ENSMUSG00000022994
is: ENSMUSG00000026567
is: K08047
is: ENSMUSG00000020431
is: ENSMUSG00000020654
is: K08046
is: ENSMUSG00000031659
is: ENSMUSG00000021536
is: K08045

679043
type: SpeciesReference
stoichiometry: 1.0
species: 631614

631614
type: Species
is: CHEBI:17489
is: http://identifiers.org/cas/60-92-4
in compartment: 623911
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3854
initial concentration: 2.6E-4
name: cAMP_c
is: C00575

679055
type: SpeciesReference
stoichiometry: 1.0
species: 624919

679031
type: SpeciesReference
stoichiometry: 1.0
species: 624331

662149
type: Constraint
message: Error: Species concentration L-Palmitoylcarnitine_c is out of the hard bounds.

750179
type: Reaction
reactant: 750203
fast: false
is: ENSMUSG00000024781
is: ENSMUSG00000026818
product: 750227
name: r1180
product: 750215
notes: EC:3.1.1.13
reversible: false
reactant: 750192

750203
type: SpeciesReference
stoichiometry: 1.0
species: 624283

624283
type: Species
is: http://identifiers.org/pubchem.compound/3303
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/cas/7732-18-5
is: CHEBI:15377
initial amount: NaN
constant: false
boundary condition: false
name: H2O_l
in compartment: 623851
is: C00001

750227
type: SpeciesReference
stoichiometry: 1.0
species: 633283

633283
type: Species
is: CHEBI:17351
is: http://identifiers.org/cas/60-33-3
is: C01595
has only substance units: false
in compartment: 623851
initial concentration: 2.6E-4
name: Linoleate_l
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/4750
constant: false

750215
type: SpeciesReference
stoichiometry: 1.0
species: 628687

628687
type: Species
is: C00187
initial concentration: 1.0E-8
is: http://identifiers.org/cas/57-88-5
is: CHEBI:16113
has only substance units: false
constant: false
boundary condition: false
in compartment: 623851
is: http://identifiers.org/pubchem.compound/3487
name: Cholesterol_l
initial amount: NaN

750192
type: SpeciesReference
stoichiometry: 1.0
species: 637878

637878
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/24702204
boundary condition: false
initial amount: NaN
in compartment: 623851
has only substance units: false
name: Cholesterol-ester-lin_l
is: CHEBI:41509
initial concentration: 2.6E-4

649958
type: Constraint
message: Error: Species concentration N-Acetylglucosamine_r is out of the hard bounds.

644885
type: Constraint
message: Warning: Species concentration H2O2_p is out of the soft bounds.

647269
type: Constraint
message: Error: Species concentration Phenylalanine_l is out of the hard bounds.

665929
type: Constraint
message: Warning: Species concentration Taurochenodeoxycholate_c is out of the soft bounds.

638154
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Phosphatidate-VLDL-TG-pool_c

630715
type: Species
is: C00387
is: http://identifiers.org/pubchem.compound/3677
is: CHEBI:16750
initial concentration: 2.6E-4
has only substance units: false
is: http://identifiers.org/cas/118-00-3
constant: false
initial amount: NaN
in compartment: 623935
name: Guanosine_s
boundary condition: true

650547
type: Constraint
message: Warning: Species concentration Palmitoyl-CoA_c is out of the soft bounds.

823548
type: Reaction
is: ENSMUSG00000040918
fast: false
reactant: 823572
name: r2138
reversible: true
reactant: 823560
product: 823596
notes: Reduced Folate Carrier (RFC) TCDB:2.A.48.2.1
product: 823584

823572
type: SpeciesReference
stoichiometry: 1.0
species: 630619

630619
type: Species
is: C00378
is: CHEBI:18385
has only substance units: false
name: Thiamin_s
initial amount: NaN
boundary condition: true
in compartment: 623935
is: http://identifiers.org/pubchem.compound/3668
initial concentration: 2.6E-4
is: http://identifiers.org/cas/59-43-8
constant: false

823560
type: SpeciesReference
stoichiometry: 1.0
species: 626623

823596
type: SpeciesReference
stoichiometry: 1.0
species: 630607

630607
type: Species
constant: false
has only substance units: false
is: http://identifiers.org/cas/59-43-8
is: C00378
in compartment: 623911
boundary condition: false
initial amount: NaN
name: Thiamin_c
is: CHEBI:18385
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3668

823584
type: SpeciesReference
stoichiometry: 1.0
species: 626635

641658
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623911
name: UDP-activated-glucose_c

769004
type: Reaction
is: R01312
product: 769052
is: ENSMUSG00000020828
reactant: 769028
notes: Phosphatidylcholine cholinephosphohydrolase Glycine, serine and threonine metabolism / Glycerophospholipid metabolism EC:3.1.4.4
is: ENSMUSG00000027695
name: r1371
is: K01114
fast: false
reactant: 769016
reversible: false
product: 769040

769052
type: SpeciesReference
stoichiometry: 1.0
species: 628747

769028
type: SpeciesReference
stoichiometry: 1.0
species: 637555

637555
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: PE-VLDL-pool_c

769016
type: SpeciesReference
stoichiometry: 1.0
species: 624259

769040
type: SpeciesReference
stoichiometry: 1.0
species: 638178

638178
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Phosphatidate-VLDL-PE-pool_c

646385
type: Constraint
message: Error: Species concentration Arginine_l is out of the hard bounds.

634783
type: Species
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
is: http://identifiers.org/pubchem.compound/7208
name: (R)-3-Hydroxybutanoyl-ACP_c
is: C04618
constant: false

782322
type: Reaction
reactant: 782346
product: 782370
fast: false
product: 782358
is: ENSMUSG00000040010
reversible: true
name: r1579
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: 782334

782346
type: SpeciesReference
stoichiometry: 1.0
species: 628075

782370
type: SpeciesReference
stoichiometry: 1.0
species: 628087

782358
type: SpeciesReference
stoichiometry: 1.0
species: 626251

782334
type: SpeciesReference
stoichiometry: 1.0
species: 626263

746987
type: Reaction
reactant: 746999
fast: false
name: r1123
reversible: true
is: ENSMUSG00000022462
notes: Major Facilitator(MFS) TCDB:2.A.18.6.5
product: 747035
product: 747023
reactant: 747011

746999
type: SpeciesReference
stoichiometry: 1.0
species: 630798

747035
type: SpeciesReference
stoichiometry: 1.0
species: 633091

747023
type: SpeciesReference
stoichiometry: 1.0
species: 630810

747011
type: SpeciesReference
stoichiometry: 1.0
species: 633079

649706
type: Constraint
message: Warning: Species concentration Putrescine_s is out of the soft bounds.

668352
type: Constraint
message: Warning: Species concentration Prothrombin_c is out of the soft bounds.

677723
type: Constraint
message: Error: Species concentration CoA-activated_acetyl_group_p is out of the hard bounds.

791453
type: Reaction
product: 791525
reactant: 791489
product: 791513
is: ENSMUSG00000031904
reversible: false
reactant: 791477
reactant: 791465
name: r1714
fast: false
product: 791501
notes: Y+LAT2 Utilized transport

791525
type: SpeciesReference
stoichiometry: 1.0
species: 633079

791489
type: SpeciesReference
stoichiometry: 1.0
species: 633091

791513
type: SpeciesReference
stoichiometry: 1.0
species: 628711

791477
type: SpeciesReference
stoichiometry: 1.0
species: 628699

791465
type: SpeciesReference
stoichiometry: 1.0
species: 626263

791501
type: SpeciesReference
stoichiometry: 1.0
species: 626251

628291
type: Species
boundary condition: true
is: CHEBI:30769
is: C00158
is: http://identifiers.org/cas/77-92-9
has only substance units: false
is: http://identifiers.org/pubchem.compound/3458
initial concentration: 0.0105
constant: false
initial amount: NaN
in compartment: 623935
name: Citrate_s

786306
type: Reaction
reversible: true
product: 786342
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: 786354
fast: false
name: r1645
reactant: 786318
is: ENSMUSG00000040010
reactant: 786330

786342
type: SpeciesReference
stoichiometry: 1.0
species: 627559

786354
type: SpeciesReference
stoichiometry: 1.0
species: 628711

786318
type: SpeciesReference
stoichiometry: 1.0
species: 627571

786330
type: SpeciesReference
stoichiometry: 1.0
species: 628699

710717
type: Reaction
is: ENSMUSG00000032478
is: ENSMUSG00000037601
notes: ATP:nucleoside-diphosphate phosphatransferase Pyrimidine metabolism EC:2.7.4.6
reversible: true
fast: false
name: r0529
is: ENSMUSG00000035984
is: ENSMUSG00000020857
product: 710753
reactant: 710729
is: ENSMUSG00000026575
is: R02331
is: K00940
is: ENSMUSG00000073435
reactant: 710741
is: ENSMUSG00000024177
product: 710765

710753
type: SpeciesReference
stoichiometry: 1.0
species: 624655

710729
type: SpeciesReference
stoichiometry: 1.0
species: 624331

710741
type: SpeciesReference
stoichiometry: 1.0
species: 633127

710765
type: SpeciesReference
stoichiometry: 1.0
species: 631134

642714
type: Constraint
message: Error: Species concentration ATP_s is out of the hard bounds.

660049
type: Constraint
message: Warning: Species concentration Malonyl-ACP_c is out of the soft bounds.

635959
type: Species
name: Glycochenodeoxycholate_b
is: CHEBI:36274
in compartment: 623887
boundary condition: true
initial concentration: 2.6E-4
initial amount: NaN
constant: false
is: C05466
is: http://identifiers.org/cas/640-79-9
has only substance units: false
is: http://identifiers.org/pubchem.compound/7826

657086
type: Constraint
message: Error: Species concentration Methylglyoxal_s is out of the hard bounds.

676427
type: Constraint
message: Error: Species concentration Collagen_CO7A1_c is out of the hard bounds.

686117
type: Reaction
notes: Cytidine-5'-monophosphate phosphohydrolase Pyrimidine metabolism EC:3.1.3.5
reactant: 686129
is: K08722
reversible: false
is: K08723
is: ENSMUSG00000032420
is: K03787
fast: false
is: R00511
name: r0135
product: 686153
reactant: 686141
is: K11751
product: 686165
is: K01081

686129
type: SpeciesReference
stoichiometry: 1.0
species: 626023

626023
type: Species
is: CHEBI:17361
in compartment: 623935
initial amount: NaN
is: C00055
constant: false
is: http://identifiers.org/cas/63-37-6
boundary condition: true
is: http://identifiers.org/pubchem.compound/3357
name: CMP_s
initial concentration: 2.6E-4
has only substance units: false

686153
type: SpeciesReference
stoichiometry: 1.0
species: 631218

631218
type: Species
name: Cytidine_s
is: CHEBI:17562
boundary condition: true
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3758
is: C00475
initial concentration: 2.6E-4
in compartment: 623935
constant: false
is: http://identifiers.org/cas/65-46-3

686141
type: SpeciesReference
stoichiometry: 1.0
species: 624271

686165
type: SpeciesReference
stoichiometry: 1.0
species: 624739

633055
type: Species
is: http://identifiers.org/pubchem.compound/4519
is: C01301
boundary condition: false
in compartment: 623911
constant: false
initial concentration: 2.6E-4
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al_c
is: CHEBI:16466
initial amount: NaN
has only substance units: false

813181
type: Reaction
reactant: 813205
fast: false
reversible: false
reactant: 813217
product: 813241
product: 813229
notes: Y+LAT2 Utilized transport
is: ENSMUSG00000031904
reactant: 813193
product: 813253
name: r1972

813205
type: SpeciesReference
stoichiometry: 1.0
species: 633091

813217
type: SpeciesReference
stoichiometry: 1.0
species: 625819

813241
type: SpeciesReference
stoichiometry: 1.0
species: 633079

813229
type: SpeciesReference
stoichiometry: 1.0
species: 628531

813193
type: SpeciesReference
stoichiometry: 1.0
species: 628543

813253
type: SpeciesReference
stoichiometry: 1.0
species: 625831

810913
type: Reaction
reversible: false
reactant: 810937
product: 810973
is: ENSMUSG00000031904
fast: false
notes: Y+LAT2 Utilized transport
product: 810961
name: r1945
reactant: 810925
product: 810985
reactant: 810949

810937
type: SpeciesReference
stoichiometry: 1.0
species: 633091

810973
type: SpeciesReference
stoichiometry: 1.0
species: 633079

810961
type: SpeciesReference
stoichiometry: 1.0
species: 626575

810925
type: SpeciesReference
stoichiometry: 1.0
species: 626587

810985
type: SpeciesReference
stoichiometry: 1.0
species: 627847

810949
type: SpeciesReference
stoichiometry: 1.0
species: 627835

677027
type: Constraint
message: Error: Species concentration Collagen_COSA1_c is out of the hard bounds.

673476
type: Constraint
message: Error: Species concentration Bilirubin-monoglucuronoside_s is out of the hard bounds.

792041
type: Reaction
reversible: false
reactant: 792065
fast: false
product: 792101
is: ENSMUSG00000031904
notes: Y+LAT2 Utilized transport
product: 792113
product: 792089
reactant: 792053
reactant: 792077
name: r1721

792065
type: SpeciesReference
stoichiometry: 1.0
species: 626539

792101
type: SpeciesReference
stoichiometry: 1.0
species: 626551

792113
type: SpeciesReference
stoichiometry: 1.0
species: 633079

792089
type: SpeciesReference
stoichiometry: 1.0
species: 626299

792053
type: SpeciesReference
stoichiometry: 1.0
species: 626311

792077
type: SpeciesReference
stoichiometry: 1.0
species: 633091

637339
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
in compartment: 623923
constant: false
is: C02050
name: Linoleoyl-CoA_r
initial concentration: 2.6E-4
is: CHEBI:15530
is: http://identifiers.org/pubchem.compound/5139

819720
type: Reaction
notes: Zinc (Zn$^{2+}$)-Iron (Fe$^{2+}$) Permease (ZIP) TCDB:2.A.55.2.3
reversible: false
product: 819756
fast: false
reactant: 819732
name: r2073
product: 819768
reactant: 819744
is: ENSMUSG00000026177

819756
type: SpeciesReference
stoichiometry: 1.0
species: 639426

639426
type: Species
is: CHEBI:29105
is: http://identifiers.org/pubchem.compound/3340
initial amount: NaN
has only substance units: false
is: http://identifiers.org/cas/7440-66-6
name: Zinc_c
in compartment: 623911
boundary condition: false
is: C00038
constant: false
initial concentration: 2.6E-4

819732
type: SpeciesReference
stoichiometry: 1.0
species: 639438

639438
type: Species
is: http://identifiers.org/pubchem.compound/3340
in compartment: 623935
name: Zinc_s
has only substance units: false
initial concentration: 2.6E-4
is: C00038
initial amount: NaN
constant: false
boundary condition: false
is: http://identifiers.org/cas/7440-66-6
is: CHEBI:29105

819768
type: SpeciesReference
stoichiometry: 1.0
species: 626623

819744
type: SpeciesReference
stoichiometry: 1.0
species: 626635

750899
type: Reaction
reactant: 750911
reactant: 750959
reactant: 750947
product: 750971
notes: Pool reaction
fast: false
reactant: 750935
name: r1192
reversible: true
reactant: 750923

750911
type: SpeciesReference
stoichiometry: 2050.0
species: 637843

750959
type: SpeciesReference
stoichiometry: 542.0
species: 637914

637914
type: Species
is: http://identifiers.org/pubchem.compound/814273
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: Cholesterol-ester-arach_r

750947
type: SpeciesReference
stoichiometry: 280.0
species: 637819

637819
type: Species
is: http://identifiers.org/pubchem.compound/107790
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: Cholesterol-ester-stea_r

750971
type: SpeciesReference
stoichiometry: 9172.0
species: 637243

637243
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: Cholesterol-ester-pool_r

750935
type: SpeciesReference
stoichiometry: 1420.0
species: 637783

637783
type: Species
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/13428
is: http://identifiers.org/cas/601-34-3
in compartment: 623923
name: Cholesterol-ester-palm_r
is: C11251
has only substance units: false
is: CHEBI:3663
initial amount: NaN
initial concentration: 2.6E-4

750923
type: SpeciesReference
stoichiometry: 4880.0
species: 637866

637866
type: Species
boundary condition: false
is: CHEBI:41509
name: Cholesterol-ester-lin_r
constant: false
is: http://identifiers.org/pubchem.compound/24702204
initial concentration: 2.6E-4
has only substance units: false
initial amount: NaN
in compartment: 623923

665053
type: Constraint
message: Error: Species concentration Decanoyl-CoA_p is out of the hard bounds.

769772
type: Reaction
reactant: 769796
notes: Transport reaction
reactant: 769784
product: 769820
reactant: 769808
reversible: true
product: 769832
product: 769844
fast: false
name: r1385

769796
type: SpeciesReference
stoichiometry: 1.0
species: 624415

769784
type: SpeciesReference
stoichiometry: 1.0
species: 624511

769820
type: SpeciesReference
stoichiometry: 1.0
species: 624463

769808
type: SpeciesReference
stoichiometry: 1.0
species: 626647

769832
type: SpeciesReference
stoichiometry: 1.0
species: 624559

769844
type: SpeciesReference
stoichiometry: 1.0
species: 626623

811585
type: Reaction
name: r1953
product: 811657
product: 811645
product: 811633
fast: false
is: ENSMUSG00000031904
reactant: 811621
notes: Y+LAT2 Utilized transport
reactant: 811609
reversible: false
reactant: 811597

811657
type: SpeciesReference
stoichiometry: 1.0
species: 626167

811645
type: SpeciesReference
stoichiometry: 1.0
species: 633079

811633
type: SpeciesReference
stoichiometry: 1.0
species: 627007

811621
type: SpeciesReference
stoichiometry: 1.0
species: 626155

811609
type: SpeciesReference
stoichiometry: 1.0
species: 633091

811597
type: SpeciesReference
stoichiometry: 1.0
species: 627019

836857
type: Reaction
reversible: true
product: 836929
product: 836905
name: r2296
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: 836881
is: ENSMUSG00000030236
reactant: 836893
product: 836917
fast: false
reactant: 836869

836929
type: SpeciesReference
stoichiometry: 1.0
species: 639930

836905
type: SpeciesReference
stoichiometry: 1.0
species: 640350

640350
type: Species
name: prostaglandin-f2beta_c
has only substance units: false
initial amount: NaN
initial concentration: 2.6E-4
is: CHEBI:28922
boundary condition: false
is: C02314
constant: false
in compartment: 623911
is: http://identifiers.org/cas/4510-16-1
is: http://identifiers.org/pubchem.compound/5368

836881
type: SpeciesReference
stoichiometry: 1.0
species: 629719

836893
type: SpeciesReference
stoichiometry: 1.0
species: 639918

836917
type: SpeciesReference
stoichiometry: 1.0
species: 629731

836869
type: SpeciesReference
stoichiometry: 1.0
species: 640362

640362
type: Species
name: prostaglandin-f2beta_s
constant: false
is: CHEBI:28922
has only substance units: false
in compartment: 623935
boundary condition: false
is: http://identifiers.org/cas/4510-16-1
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5368
is: C02314
initial concentration: 2.6E-4

734791
type: Reaction
product: 734814
reactant: 734802
notes: Facilitated diffusion
fast: false
reversible: false
name: r0963

734814
type: SpeciesReference
stoichiometry: 1.0
species: 631290

734802
type: SpeciesReference
stoichiometry: 1.0
species: 631302

631302
type: Species
is: C00504
is: http://identifiers.org/cas/59-30-3
in compartment: 623935
boundary condition: true
constant: false
has only substance units: false
name: Folate_s
initial concentration: 2.6E-4
is: CHEBI:27470
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3787

649826
type: Constraint
message: Warning: Species concentration Histidine_m is out of the soft bounds.

651770
type: Constraint
message: Warning: Species concentration UDP-N-acetyl-D-galactosamine_c is out of the soft bounds.

655166
type: Constraint
message: Error: Species concentration dUMP_c is out of the hard bounds.

650930
type: Constraint
message: Warning: Species concentration UDP-glucuronate_c is out of the soft bounds.

638022
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1-Acylglycerol-3P-VLDL-PC-pool_c

639522
type: Species
is: http://identifiers.org/pubchem.compound/17395746
constant: false
is: C14748
initial concentration: 2.6E-4
name: 20-hydroxy-arachidonate_c
in compartment: 623911
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:34306
is: http://identifiers.org/cas/79551-86-3

688842
type: Reaction
is: ENSMUSG00000035561
reactant: 688866
reactant: 688878
is: ENSMUSG00000010025
is: ENSMUSG00000015134
is: ENSMUSG00000053279
product: 688890
is: ENSMUSG00000024885
product: 688902
is: ENSMUSG00000075296
fast: false
is: K00128
is: K00129
notes: Acetaldehyde:NADP+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.2.1.5
reactant: 688854
is: ENSMUSG00000019102
name: r0177
is: R00711
reversible: false

688866
type: SpeciesReference
stoichiometry: 1.0
species: 624259

688878
type: SpeciesReference
stoichiometry: 1.0
species: 624547

688890
type: SpeciesReference
stoichiometry: 1.0
species: 625531

688902
type: SpeciesReference
stoichiometry: 1.0
species: 624499

688854
type: SpeciesReference
stoichiometry: 1.0
species: 626791

626791
type: Species
in compartment: 623911
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3384
has only substance units: false
name: Acetaldehyde_c
constant: false
is: http://identifiers.org/cas/75-07-0
boundary condition: false
initial amount: NaN
is: CHEBI:15343
is: C00084

774163
type: Reaction
product: 774211
product: 774199
reactant: 774187
reactant: 774175
notes: Transport reaction
fast: false
reversible: false
name: r1456

774211
type: SpeciesReference
stoichiometry: 1.0
species: 626647

774199
type: SpeciesReference
stoichiometry: 1.0
species: 626575

774187
type: SpeciesReference
stoichiometry: 1.0
species: 626623

774175
type: SpeciesReference
stoichiometry: 1.0
species: 626611

626611
type: Species
has only substance units: false
is: http://identifiers.org/cas/63-91-2
boundary condition: false
constant: false
initial concentration: 2.6E-4
in compartment: 623863
is: http://identifiers.org/pubchem.compound/3379
is: CHEBI:17295
is: C00079
name: Phenylalanine_m
initial amount: NaN

652406
type: Constraint
message: Error: Species concentration 10-Formyl-THF_c is out of the hard bounds.

841500
type: Reaction
is: ENSMUSG00000003528
name: r2371
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: 841536
reversible: true
product: 841548
fast: false
reactant: 841512
reactant: 841524

841536
type: SpeciesReference
stoichiometry: 1.0
species: 628279

841548
type: SpeciesReference
stoichiometry: 1.0
species: 630906

841512
type: SpeciesReference
stoichiometry: 1.0
species: 628303

628303
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3458
constant: false
is: C00158
has only substance units: false
is: http://identifiers.org/cas/77-92-9
is: CHEBI:30769
name: Citrate_m
initial concentration: 0.0105
in compartment: 623863
boundary condition: false

841524
type: SpeciesReference
stoichiometry: 1.0
species: 630894

641382
type: Species
is: Q9P218
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_COKA1_c

846563
type: Reaction
product: 846587
reactant: 846575
notes: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is: ENSMUSG00000027359
fast: false
reversible: false
name: r2445

846587
type: SpeciesReference
stoichiometry: 1.0
species: 639498

639498
type: Species
name: myristic-acid_c
is: CHEBI:28875
constant: false
is: http://identifiers.org/cas/544-63-8
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/8659
is: C06424
initial amount: NaN
in compartment: 623911
initial concentration: 2.6E-4

846575
type: SpeciesReference
stoichiometry: 1.0
species: 639510

639510
type: Species
in compartment: 623935
constant: false
is: http://identifiers.org/cas/544-63-8
is: CHEBI:28875
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/8659
has only substance units: false
name: myristic-acid_s
is: C06424
initial concentration: 2.6E-4

672168
type: Constraint
message: Warning: Species concentration Proton-gradient_m is out of the soft bounds.

650474
type: Constraint
message: Warning: Species concentration Nicotinamide_c is out of the soft bounds.

660061
type: Constraint
message: Error: Species concentration N-Methylethanolamine-P_c is out of the hard bounds.

634267
type: Species
is: C03428
in compartment: 623923
initial concentration: 2.6E-4
name: Presqualene-PP_r
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/6255
initial amount: NaN
is: CHEBI:15442
constant: false

836101
type: Reaction
fast: false
product: 836173
product: 836161
reactant: 836137
is: ENSMUSG00000030236
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
product: 836149
reactant: 836125
reactant: 836113
name: r2287

836173
type: SpeciesReference
stoichiometry: 1.0
species: 639930

836161
type: SpeciesReference
stoichiometry: 1.0
species: 629731

836137
type: SpeciesReference
stoichiometry: 1.0
species: 639918

836149
type: SpeciesReference
stoichiometry: 1.0
species: 640278

640278
type: Species
is: C06439
initial concentration: 2.6E-4
is: http://identifiers.org/cas/802-31-3
initial amount: NaN
boundary condition: false
is: CHEBI:28031
name: prostaglandin-e3_c
has only substance units: false
is: http://identifiers.org/pubchem.compound/8673
constant: false
in compartment: 623911

836125
type: SpeciesReference
stoichiometry: 1.0
species: 629719

836113
type: SpeciesReference
stoichiometry: 1.0
species: 640290

655622
type: Constraint
message: Error: Species concentration Ubiquinol_m is out of the hard bounds.

661777
type: Constraint
message: Warning: Species concentration O-Acetylcarnitine_r is out of the soft bounds.

674700
type: Constraint
message: Error: Species concentration prostaglandin-f1alpha_s is out of the hard bounds.

676295
type: Constraint
message: Warning: Species concentration Collagen_CO5A3_c is out of the soft bounds.

671388
type: Constraint
message: Error: Species concentration CL-pool_m is out of the hard bounds.

667488
type: Constraint
message: Warning: Species concentration 2,5-Diamino-6-(5-triphosphoryl-3,4-trihydroxy-2-oxopentyl)-_amino-4-oxopyrimidine_c is out of the soft bounds.

826127
type: Reaction
is: ENSMUSG00000041698
is: ENSMUSG00000079262
reactant: 826163
name: r2169
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: 826151
product: 826199
product: 826187
is: ENSMUSG00000063975
fast: false
product: 826175
reactant: 826139
is: ENSMUSG00000030237
reversible: true

826163
type: SpeciesReference
stoichiometry: 1.0
species: 639918

826151
type: SpeciesReference
stoichiometry: 1.0
species: 629719

826199
type: SpeciesReference
stoichiometry: 1.0
species: 639930

826187
type: SpeciesReference
stoichiometry: 1.0
species: 629731

826175
type: SpeciesReference
stoichiometry: 1.0
species: 639738

639738
type: Species
is: CHEBI:36259
in compartment: 623911
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 2.6E-4
name: taurolithocholate_c
is: http://identifiers.org/pubchem.compound/5584
boundary condition: false
is: http://identifiers.org/cas/516-90-5
is: C02592

826139
type: SpeciesReference
stoichiometry: 1.0
species: 639750

639750
type: Species
is: C02592
in compartment: 623935
is: http://identifiers.org/pubchem.compound/5584
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:36259
name: taurolithocholate_s
is: http://identifiers.org/cas/516-90-5
constant: false
initial concentration: 2.6E-4

639090
type: Species
boundary condition: true
constant: false
is: http://identifiers.org/pubchem.compound/6864
in compartment: 623911
has only substance units: false
name: Methylthioribose-1P_c
initial concentration: 2.6E-4
initial amount: NaN
is: C04188

662197
type: Constraint
message: Error: Species concentration L-Palmitoylcarnitine_p is out of the hard bounds.

645833
type: Constraint
message: Error: Species concentration Aspartate_m is out of the hard bounds.

817020
type: Reaction
reactant: 817044
is: ENSMUSG00000030492
fast: false
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
name: r2028
product: 817056
reversible: false
reactant: 817032
product: 817068

817044
type: SpeciesReference
stoichiometry: 1.0
species: 626407

817056
type: SpeciesReference
stoichiometry: 1.0
species: 626503

817032
type: SpeciesReference
stoichiometry: 1.0
species: 626515

817068
type: SpeciesReference
stoichiometry: 1.0
species: 626419

643938
type: Constraint
message: Error: Species concentration PPi_n is out of the hard bounds.

651650
type: Constraint
message: Warning: Species concentration Glucuronate_c is out of the soft bounds.

739986
type: Reaction
product: 740010
reactant: 739998
notes: Vesicular transport
fast: false
reversible: false
name: r1074

740010
type: SpeciesReference
stoichiometry: 1.0
species: 626575

739998
type: SpeciesReference
stoichiometry: 1.0
species: 626599

671136
type: Constraint
message: Warning: Species concentration 1-Acylglycerol-VLDL-SM-pool_c is out of the soft bounds.

651242
type: Constraint
message: Warning: Species concentration Glycerone_s is out of the soft bounds.

671784
type: Constraint
message: Warning: Species concentration Dihomo-gamma-linolenoyl-CoA_c is out of the soft bounds.

667236
type: Constraint
message: Error: Species concentration L-erythro-4-Hydroxyglutamate_m is out of the hard bounds.

718084
type: Reaction
reactant: 718120
is: ENSMUSG00000030382
reactant: 718108
reactant: 718096
is: R03974
product: 718132
reversible: true
fast: false
product: 718144
name: r0651
product: 718156
notes: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7

718120
type: SpeciesReference
stoichiometry: 1.0
species: 633799

718108
type: SpeciesReference
stoichiometry: 1.0
species: 624799

718096
type: SpeciesReference
stoichiometry: 1.0
species: 624331

718132
type: SpeciesReference
stoichiometry: 1.0
species: 625135

718144
type: SpeciesReference
stoichiometry: 1.0
species: 624919

718156
type: SpeciesReference
stoichiometry: 1.0
species: 635551

662953
type: Constraint
message: Warning: Species concentration Tagatose-1,6PP_c is out of the soft bounds.

669324
type: Constraint
message: Error: Species concentration SM-pool_r is out of the hard bounds.

664165
type: Constraint
message: Error: Species concentration 14-Demethyllanosterol_r is out of the hard bounds.

691253
type: Reaction
product: 691301
fast: false
product: 691289
is: ENSMUSG00000033427
notes: N-Carbamoyl-beta-alanine amidohydrolase Pyrimidine metabolism / beta-Alanine metabolism / Pantothenate and CoA biosynthesis EC:3.5.1.6
product: 691313
is: R00905
reactant: 691277
reversible: false
reactant: 691265
name: r0216
is: K01431

691301
type: SpeciesReference
stoichiometry: 1.0
species: 624859

691289
type: SpeciesReference
stoichiometry: 1.0
species: 627055

691313
type: SpeciesReference
stoichiometry: 1.0
species: 624979

691277
type: SpeciesReference
stoichiometry: 1.0
species: 633919

633919
type: Species
boundary condition: false
constant: false
name: 3-Ureidopropionate_c
in compartment: 623911
initial concentration: 2.6E-4
has only substance units: false
is: C02642
is: http://identifiers.org/pubchem.compound/5621
initial amount: NaN
is: CHEBI:18261

691265
type: SpeciesReference
stoichiometry: 1.0
species: 624259

671532
type: Constraint
message: Error: Species concentration PGP-CL-pool_m is out of the hard bounds.

822300
type: Reaction
fast: false
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
name: r2116
reversible: true
reactant: 822324
reactant: 822312
product: 822348
is: ENSMUSG00000032902
product: 822336

822324
type: SpeciesReference
stoichiometry: 1.0
species: 628339

822312
type: SpeciesReference
stoichiometry: 1.0
species: 626071

822348
type: SpeciesReference
stoichiometry: 1.0
species: 628351

822336
type: SpeciesReference
stoichiometry: 1.0
species: 626059

639978
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623887
name: S-glutathionyl-ethacrynic-acid_b

783881
type: Reaction
reactant: 783905
reversible: true
product: 783917
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
name: r1605
product: 783929
reactant: 783893
is: ENSMUSG00000040010
fast: false

783905
type: SpeciesReference
stoichiometry: 1.0
species: 628699

783917
type: SpeciesReference
stoichiometry: 1.0
species: 626407

783929
type: SpeciesReference
stoichiometry: 1.0
species: 628711

783893
type: SpeciesReference
stoichiometry: 1.0
species: 626419

643026
type: Constraint
message: Error: Species concentration NADPH_c is out of the hard bounds.

668412
type: Constraint
message: Error: Species concentration ApoTransferin_c is out of the hard bounds.

640710
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: trans,cis-octadeca-2,9-dienoyl-CoA_m

644933
type: Constraint
message: Warning: Species concentration UDP-glucose_c is out of the soft bounds.

646553
type: Constraint
message: Error: Species concentration Glutamine_s is out of the hard bounds.

624151
type: Species
is: P02654
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: ApoC1_c

747167
type: Reaction
notes: Major Facilitator(MFS) TCDB:2.A.18.6.5
product: 747203
name: r1126
reversible: true
product: 747215
fast: false
reactant: 747179
is: ENSMUSG00000022462
reactant: 747191

747203
type: SpeciesReference
stoichiometry: 1.0
species: 626587

747215
type: SpeciesReference
stoichiometry: 1.0
species: 633091

747179
type: SpeciesReference
stoichiometry: 1.0
species: 626575

747191
type: SpeciesReference
stoichiometry: 1.0
species: 633079

810241
type: Reaction
reactant: 810253
product: 810289
product: 810301
is: ENSMUSG00000031904
fast: false
reversible: false
product: 810313
notes: Y+LAT2 Utilized transport
reactant: 810265
reactant: 810277
name: r1937

810253
type: SpeciesReference
stoichiometry: 1.0
species: 626551

810289
type: SpeciesReference
stoichiometry: 1.0
species: 626539

810301
type: SpeciesReference
stoichiometry: 1.0
species: 633079

810313
type: SpeciesReference
stoichiometry: 1.0
species: 625831

810265
type: SpeciesReference
stoichiometry: 1.0
species: 633091

810277
type: SpeciesReference
stoichiometry: 1.0
species: 625819

644525
type: Constraint
message: Warning: Species concentration Acetyl-CoA_r is out of the soft bounds.

663121
type: Constraint
message: Warning: Species concentration 3-Hydroxyisobutyryl-CoA_m is out of the soft bounds.

657530
type: Constraint
message: Warning: Species concentration 3-Sulfinoalanine_c is out of the soft bounds.

730891
type: Reaction
fast: false
product: 730987
product: 730975
product: 730963
product: 730951
reactant: 730939
notes: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 TCDB:2.A.23.2.1 TCDB:2.A.23.2.2 TCDB:2.A.23.2.3
reactant: 730915
reactant: 730903
reactant: 730927
reversible: false
is: ENSMUSG00000024935
name: r0878

730987
type: SpeciesReference
stoichiometry: 1.0
species: 629227

730975
type: SpeciesReference
stoichiometry: 1.0
species: 626623

730963
type: SpeciesReference
stoichiometry: 3.0
species: 633079

730951
type: SpeciesReference
stoichiometry: 1.0
species: 625291

730939
type: SpeciesReference
stoichiometry: 1.0
species: 629215

730915
type: SpeciesReference
stoichiometry: 3.0
species: 633091

730903
type: SpeciesReference
stoichiometry: 1.0
species: 625303

730927
type: SpeciesReference
stoichiometry: 1.0
species: 626635

634135
type: Species
initial concentration: 2.6E-4
boundary condition: false
in compartment: 623863
name: 3-Methylglutaconyl-CoA_m
is: CHEBI:15488
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6102
constant: false
is: C03231
has only substance units: false

823320
type: Reaction
fast: false
product: 823356
is: ENSMUSG00000032902
product: 823368
reactant: 823332
name: r2133
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: 823344

823356
type: SpeciesReference
stoichiometry: 1.0
species: 632659

823368
type: SpeciesReference
stoichiometry: 1.0
species: 636655

823332
type: SpeciesReference
stoichiometry: 1.0
species: 632671

823344
type: SpeciesReference
stoichiometry: 1.0
species: 636643

776767
type: Reaction
is: ENSMUSG00000021135
fast: false
name: r1500
product: 776803
reversible: false
reactant: 776779
reactant: 776791
product: 776815
notes: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1

776803
type: SpeciesReference
stoichiometry: 1.0
species: 639762

639762
type: Species
initial amount: NaN
is: http://identifiers.org/cas/474-74-8
has only substance units: false
constant: false
initial concentration: 2.6E-4
boundary condition: false
name: glycolithocholate_c
is: C15557
is: http://identifiers.org/pubchem.compound/17396549
in compartment: 623911

776779
type: SpeciesReference
stoichiometry: 1.0
species: 639774

639774
type: Species
constant: false
boundary condition: false
initial amount: NaN
in compartment: 623935
initial concentration: 2.6E-4
has only substance units: false
is: http://identifiers.org/pubchem.compound/17396549
is: C15557
name: glycolithocholate_s
is: http://identifiers.org/cas/474-74-8

776791
type: SpeciesReference
stoichiometry: 2.0
species: 633091

776815
type: SpeciesReference
stoichiometry: 2.0
species: 633079

659845
type: Constraint
message: Error: Species concentration Inositol-1P_c is out of the hard bounds.

730687
type: Reaction
product: 730735
reactant: 730711
product: 730723
reversible: false
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.14.3
reactant: 730699
name: r0875
fast: false
is: ENSMUSG00000019082

730735
type: SpeciesReference
stoichiometry: 1.0
species: 626647

730711
type: SpeciesReference
stoichiometry: 1.0
species: 626623

730723
type: SpeciesReference
stoichiometry: 1.0
species: 625327

730699
type: SpeciesReference
stoichiometry: 1.0
species: 625291

800020
type: Reaction
reversible: false
reactant: 800044
is: ENSMUSG00000031904
product: 800080
reactant: 800032
fast: false
product: 800068
reactant: 800056
product: 800092
notes: Y+LAT2 Utilized transport
name: r1816

800044
type: SpeciesReference
stoichiometry: 1.0
species: 628075

800080
type: SpeciesReference
stoichiometry: 1.0
species: 628087

800032
type: SpeciesReference
stoichiometry: 1.0
species: 627571

800068
type: SpeciesReference
stoichiometry: 1.0
species: 627559

800056
type: SpeciesReference
stoichiometry: 1.0
species: 633091

800092
type: SpeciesReference
stoichiometry: 1.0
species: 633079

740130
type: Reaction
product: 740154
reactant: 740142
notes: Vesicular transport
fast: false
reversible: false
name: r1078

740154
type: SpeciesReference
stoichiometry: 1.0
species: 626731

740142
type: SpeciesReference
stoichiometry: 1.0
species: 626695

635671
type: Species
in compartment: 623935
has only substance units: false
is: http://identifiers.org/pubchem.compound/7770
initial concentration: 2.6E-4
constant: false
is: C05403
name: 3-Ketolactose_s
initial amount: NaN
boundary condition: true

645593
type: Constraint
message: Error: Species concentration GTP_c is out of the hard bounds.

667116
type: Constraint
message: Error: Species concentration Bilirubin-bisglucuronoside_s is out of the hard bounds.

782682
type: Reaction
reactant: 782694
reversible: true
name: r1585
product: 782718
product: 782730
is: ENSMUSG00000040010
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: 782706
fast: false

782694
type: SpeciesReference
stoichiometry: 1.0
species: 626311

782718
type: SpeciesReference
stoichiometry: 1.0
species: 626299

782730
type: SpeciesReference
stoichiometry: 1.0
species: 626419

782706
type: SpeciesReference
stoichiometry: 1.0
species: 626407

672708
type: Constraint
message: Error: Species concentration GM4-pool_s is out of the hard bounds.

646301
type: Constraint
message: Warning: Species concentration Sulfate_m is out of the soft bounds.

676163
type: Constraint
message: Error: Species concentration Collagen_CO4A4_c is out of the hard bounds.

786066
type: Reaction
reversible: true
reactant: 786078
product: 786114
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: 786102
is: ENSMUSG00000040010
fast: false
name: r1641
reactant: 786090

786078
type: SpeciesReference
stoichiometry: 1.0
species: 627019

786114
type: SpeciesReference
stoichiometry: 1.0
species: 630810

786102
type: SpeciesReference
stoichiometry: 1.0
species: 627007

786090
type: SpeciesReference
stoichiometry: 1.0
species: 630798

679559
type: Reaction
fast: false
reversible: false
is: ENSMUSG00000041608
notes: ATP pyrophosphohydrolase Purine metabolism EC:3.6.1.5
is: K01510
product: 679607
reactant: 679583
is: ENSMUSG00000036813
product: 679595
reactant: 679571
is: ENSMUSG00000048120
name: r0029
is: R00122

679607
type: SpeciesReference
stoichiometry: 1.0
species: 624739

679583
type: SpeciesReference
stoichiometry: 1.0
species: 624271

679595
type: SpeciesReference
stoichiometry: 1.0
species: 625147

679571
type: SpeciesReference
stoichiometry: 1.0
species: 624667

624667
type: Species
name: ADP_s
is: http://identifiers.org/cas/20398-34-9
boundary condition: true
initial concentration: 1.32E-4
is: http://identifiers.org/pubchem.compound/3310
in compartment: 623935
constant: false
is: C00008
has only substance units: false
initial amount: NaN
is: CHEBI:16761

758782
type: Reaction
product: 758806
reactant: 758794
notes: Pool reaction
fast: false
reversible: false
name: r1306

758806
type: SpeciesReference
stoichiometry: 1.0
species: 638682

758794
type: SpeciesReference
stoichiometry: 1.0
species: 638670

740730
type: Reaction
fast: false
reactant: 740970
reactant: 740742
reactant: 740850
reactant: 740910
notes: albumin Protein assembly
reversible: false
reactant: 740898
product: 741030
reactant: 740862
reactant: 740946
reactant: 740886
product: 741042
reactant: 740994
reactant: 740838
reactant: 740814
product: 741018
reactant: 740958
reactant: 740934
name: r1092
reactant: 740874
reactant: 740826
reactant: 740802
is: ENSMUSG00000029368
reactant: 740922
reactant: 740790
reactant: 740766
product: 741006
reactant: 740982
reactant: 740778
reactant: 740754
product: 741054

740970
type: SpeciesReference
stoichiometry: 17.0
species: 628147

740742
type: SpeciesReference
stoichiometry: 63.0
species: 625675

740850
type: SpeciesReference
stoichiometry: 24.0
species: 628075

740910
type: SpeciesReference
stoichiometry: 43.0
species: 628531

740898
type: SpeciesReference
stoichiometry: 19.0
species: 626695

741030
type: SpeciesReference
stoichiometry: 609.0
species: 624919

740862
type: SpeciesReference
stoichiometry: 28.0
species: 626299

740946
type: SpeciesReference
stoichiometry: 2436.0
species: 624331

740886
type: SpeciesReference
stoichiometry: 2.0
species: 626539

741042
type: SpeciesReference
stoichiometry: 1827.0
species: 624655

740994
type: SpeciesReference
stoichiometry: 60.0
species: 625819

740838
type: SpeciesReference
stoichiometry: 35.0
species: 626575

740814
type: SpeciesReference
stoichiometry: 64.0
species: 627559

741018
type: SpeciesReference
stoichiometry: 609.0
species: 625135

740958
type: SpeciesReference
stoichiometry: 2436.0
species: 624259

740934
type: SpeciesReference
stoichiometry: 20.0
species: 626251

740874
type: SpeciesReference
stoichiometry: 29.0
species: 628699

740826
type: SpeciesReference
stoichiometry: 7.0
species: 626407

740802
type: SpeciesReference
stoichiometry: 9.0
species: 630798

740922
type: SpeciesReference
stoichiometry: 62.0
species: 625291

740790
type: SpeciesReference
stoichiometry: 16.0
species: 627835

740766
type: SpeciesReference
stoichiometry: 35.0
species: 627007

741006
type: SpeciesReference
stoichiometry: 1.0
species: 623947

623947
type: Species
is: P02768
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Albumin_c

740982
type: SpeciesReference
stoichiometry: 36.0
species: 625867

740778
type: SpeciesReference
stoichiometry: 13.0
species: 625627

740754
type: SpeciesReference
stoichiometry: 27.0
species: 626155

741054
type: SpeciesReference
stoichiometry: 1827.0
species: 624727

625903
type: Species
is: C00049
boundary condition: false
constant: false
is: CHEBI:17053
has only substance units: false
in compartment: 623863
name: Aspartate_m
is: http://identifiers.org/pubchem.compound/3351
initial amount: NaN
initial concentration: 5.5E-4
is: http://identifiers.org/cas/56-84-8

719932
type: Reaction
product: 719968
reactant: 719944
is: K00209
product: 719980
is: ENSMUSG00000025153
is: K10780
name: r0682
reversible: true
fast: false
is: R04430
notes: Butyryl-[acyl-carrier protein]:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) Fatty acid biosynthesis EC:2.1.3.85
is: K00665
reactant: 719956

719968
type: SpeciesReference
stoichiometry: 1.0
species: 634591

634591
type: Species
name: But-2-enoyl-ACP_c
initial concentration: 2.6E-4
constant: false
boundary condition: false
in compartment: 623911
is: http://identifiers.org/pubchem.compound/6911
is: C04246
initial amount: NaN
has only substance units: false

719944
type: SpeciesReference
stoichiometry: 1.0
species: 636223

636223
type: Species
name: Butyryl-ACP_c
boundary condition: false
is: http://identifiers.org/pubchem.compound/8040
in compartment: 623911
is: C05745
initial concentration: 2.6E-4
constant: false
has only substance units: false
initial amount: NaN

719980
type: SpeciesReference
stoichiometry: 1.0
species: 624499

719956
type: SpeciesReference
stoichiometry: 1.0
species: 624547

645701
type: Constraint
message: Warning: Species concentration Lysine_s is out of the soft bounds.

843024
type: Reaction
fast: false
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: 843084
reactant: 843036
product: 843072
reactant: 843048
reactant: 843060
name: r2392
reversible: true
product: 843096
is: ENSMUSG00000003528

843084
type: SpeciesReference
stoichiometry: 1.0
species: 626623

843036
type: SpeciesReference
stoichiometry: 1.0
species: 630906

843072
type: SpeciesReference
stoichiometry: 1.0
species: 630894

843048
type: SpeciesReference
stoichiometry: 1.0
species: 626647

843060
type: SpeciesReference
stoichiometry: 1.0
species: 628915

843096
type: SpeciesReference
stoichiometry: 1.0
species: 628927

670692
type: Constraint
message: Error: Species concentration Triacylglycerol-VLDL-pool_r is out of the hard bounds.

645245
type: Constraint
message: Warning: Species concentration OAA_c is out of the soft bounds.

732211
type: Reaction
product: 732235
reactant: 732223
notes: Postulated transport reaction
fast: false
reversible: true
name: r0904

732235
type: SpeciesReference
stoichiometry: 1.0
species: 627439

627439
type: Species
name: Glycerol_m
is: http://identifiers.org/pubchem.compound/3416
is: CHEBI:17754
boundary condition: false
is: http://identifiers.org/cas/56-81-5
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
has only substance units: false
constant: false
is: C00116

732223
type: SpeciesReference
stoichiometry: 1.0
species: 627415

823944
type: Reaction
is: ENSMUSG00000079262
is: ENSMUSG00000030237
product: 824004
name: r2143
is: ENSMUSG00000041698
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: 823956
is: ENSMUSG00000063975
product: 824016
reversible: true
fast: false
product: 823992
reactant: 823968
reactant: 823980

824004
type: SpeciesReference
stoichiometry: 1.0
species: 629731

823956
type: SpeciesReference
stoichiometry: 1.0
species: 639726

639726
type: Species
is: http://identifiers.org/cas/434-13-9
constant: false
in compartment: 623935
is: http://identifiers.org/pubchem.compound/6705
is: CHEBI:16325
initial amount: NaN
has only substance units: false
is: C03990
initial concentration: 2.6E-4
boundary condition: false
name: lithocholate_s

824016
type: SpeciesReference
stoichiometry: 1.0
species: 625927

823992
type: SpeciesReference
stoichiometry: 1.0
species: 639714

639714
type: Species
boundary condition: false
in compartment: 623911
is: C03990
is: http://identifiers.org/pubchem.compound/6705
is: http://identifiers.org/cas/434-13-9
has only substance units: false
name: lithocholate_c
initial amount: NaN
constant: false
initial concentration: 2.6E-4
is: CHEBI:16325

823968
type: SpeciesReference
stoichiometry: 1.0
species: 629719

823980
type: SpeciesReference
stoichiometry: 1.0
species: 625915

727448
type: Reaction
product: 727472
reactant: 727460
notes: Vesicular transport
fast: false
reversible: false
name: r0807

727472
type: SpeciesReference
stoichiometry: 1.0
species: 624043

624043
type: Species
is: P01009
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623851
name: Antitrypsin_l

727460
type: SpeciesReference
stoichiometry: 1.0
species: 624031

649622
type: Constraint
message: Error: Species concentration Methanol_c is out of the hard bounds.

704298
type: Reaction
reactant: 704322
reactant: 704310
notes: ATP:pyridoxal 5'-phosphotransferase Vitamin B6 metabolism EC:2.7.1.35
reversible: true
is: R01909
product: 704346
fast: false
product: 704334
is: K00868
is: ENSMUSG00000032788
name: r0428

704322
type: SpeciesReference
stoichiometry: 1.0
species: 629923

629923
type: Species
name: Pyridoxine_c
is: CHEBI:16709
boundary condition: false
constant: false
has only substance units: false
in compartment: 623911
is: C00314
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3608
is: http://identifiers.org/cas/65-23-6
initial concentration: 2.6E-4

704310
type: SpeciesReference
stoichiometry: 1.0
species: 624331

704346
type: SpeciesReference
stoichiometry: 1.0
species: 631746

631746
type: Species
has only substance units: false
in compartment: 623911
initial concentration: 2.6E-4
is: http://identifiers.org/cas/447-05-2
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:28803
is: C00627
name: Pyridoxine-P_c
is: http://identifiers.org/pubchem.compound/3900

704334
type: SpeciesReference
stoichiometry: 1.0
species: 624655

665365
type: Constraint
message: Error: Species concentration Lactose-6P_s is out of the hard bounds.

639846
type: Species
is: http://identifiers.org/pubchem.compound/12310288
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623935
name: glycoursodeoxycholate_s

789773
type: Reaction
name: r1694
reversible: false
is: ENSMUSG00000031904
notes: Y+LAT2 Utilized transport
reactant: 789785
fast: false
product: 789845
product: 789833
reactant: 789809
product: 789821
reactant: 789797

789785
type: SpeciesReference
stoichiometry: 1.0
species: 625687

789845
type: SpeciesReference
stoichiometry: 1.0
species: 633079

789833
type: SpeciesReference
stoichiometry: 1.0
species: 627019

789809
type: SpeciesReference
stoichiometry: 1.0
species: 633091

789821
type: SpeciesReference
stoichiometry: 1.0
species: 625675

789797
type: SpeciesReference
stoichiometry: 1.0
species: 627007

845843
type: Reaction
product: 845891
name: r2431
fast: false
product: 845879
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.16.1
reactant: 845855
reactant: 845867
reversible: false
is: ENSMUSG00000020744

845891
type: SpeciesReference
stoichiometry: 1.0
species: 624655

845879
type: SpeciesReference
stoichiometry: 1.0
species: 629695

629695
type: Species
is: CHEBI:16497
is: http://identifiers.org/cas/2564-35-4
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 2.6E-4
has only substance units: false
name: dGTP_m
is: http://identifiers.org/pubchem.compound/3581
in compartment: 623863
is: C00286

845855
type: SpeciesReference
stoichiometry: 1.0
species: 629671

845867
type: SpeciesReference
stoichiometry: 1.0
species: 624691

640650
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: palmitoleoyl-Carnitine_c

682007
type: Reaction
notes: Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
is: ENSMUSG00000027605
name: r0068
reactant: 682020
is: ENSMUSG00000027452
product: 682059
is: K01895
fast: false
reactant: 682033
reversible: false
is: R00236
product: 682046

682020
type: SpeciesReference
stoichiometry: 1.0
species: 636667

682059
type: SpeciesReference
stoichiometry: 1.0
species: 625255

682033
type: SpeciesReference
stoichiometry: 1.0
species: 624799

682046
type: SpeciesReference
stoichiometry: 1.0
species: 625135

646421
type: Constraint
message: Warning: Species concentration Arginine_m is out of the soft bounds.

666384
type: Constraint
message: Warning: Species concentration 5-Hydroxyindoleacetate_c is out of the soft bounds.

628363
type: Species
has only substance units: false
is: C00163
is: http://identifiers.org/pubchem.compound/3463
in compartment: 623863
is: CHEBI:30768
initial amount: NaN
constant: false
is: http://identifiers.org/cas/79-09-4
name: Propanoate_m
boundary condition: false
initial concentration: 2.6E-4

665761
type: Constraint
message: Warning: Species concentration 3alpha,7alpha,12alpha-Trihydroxycoprostane_m is out of the soft bounds.

709877
type: Reaction
product: 709925
reactant: 709901
reactant: 709889
is: ENSMUSG00000041939
is: R02245
name: r0515
product: 709913
fast: false
notes: ATP:(R)-mevalonate 5-phosphotransferase Biosynthesis of steroids EC:2.7.1.36
is: K00869
reversible: true

709925
type: SpeciesReference
stoichiometry: 1.0
species: 632731

632731
type: Species
initial concentration: 2.6E-4
initial amount: NaN
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/4339
in compartment: 623899
is: C01107
is: CHEBI:17436
has only substance units: false
name: (R)-5-Phosphomevalonate_p

709901
type: SpeciesReference
stoichiometry: 1.0
species: 630930

630930
type: Species
in compartment: 623899
is: C00418
initial amount: NaN
has only substance units: false
name: (R)-Mevalonate_p
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3708
is: http://identifiers.org/cas/150-97-0
initial concentration: 2.6E-4
is: CHEBI:17710

709889
type: SpeciesReference
stoichiometry: 1.0
species: 624379

624379
type: Species
initial concentration: 3.38E-4
initial amount: NaN
is: C00002
name: ATP_p
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3304
has only substance units: false
in compartment: 623899
is: CHEBI:15422
is: http://identifiers.org/cas/56-65-5

709913
type: SpeciesReference
stoichiometry: 1.0
species: 624703

624703
type: Species
has only substance units: false
initial concentration: 1.32E-4
is: http://identifiers.org/pubchem.compound/3310
in compartment: 623899
is: C00008
is: CHEBI:16761
is: http://identifiers.org/cas/20398-34-9
name: ADP_p
boundary condition: false
initial amount: NaN
constant: false

879689
type: Reaction
reactant: 879857
reactant: 879761
is: ENSMUSG00000057606
reactant: 879941
product: 880001
product: 879989
reactant: 879929
reactant: 879785
name: r2624
reactant: 879737
reversible: false
reactant: 879713
reactant: 879953
reactant: 879833
reactant: 879809
reactant: 879881
product: 880013
reactant: 879725
product: 879965
reactant: 879893
fast: false
product: 879977
reactant: 879905
reactant: 879749
reactant: 879869
reactant: 879797
notes: collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase Protein assembly
reactant: 879845
reactant: 879917
reactant: 879773
reactant: 879701
reactant: 879821

879857
type: SpeciesReference
stoichiometry: 19.0
species: 626251

879761
type: SpeciesReference
stoichiometry: 86.0
species: 625627

879941
type: SpeciesReference
stoichiometry: 1820.0
species: 624331

880001
type: SpeciesReference
stoichiometry: 455.0
species: 625135

879989
type: SpeciesReference
stoichiometry: 1365.0
species: 624727

879929
type: SpeciesReference
stoichiometry: 14.0
species: 626695

879785
type: SpeciesReference
stoichiometry: 12.0
species: 630798

879737
type: SpeciesReference
stoichiometry: 21.0
species: 625291

879713
type: SpeciesReference
stoichiometry: 15.0
species: 627007

879953
type: SpeciesReference
stoichiometry: 1820.0
species: 624259

879833
type: SpeciesReference
stoichiometry: 11.0
species: 628147

879809
type: SpeciesReference
stoichiometry: 36.0
species: 627559

879881
type: SpeciesReference
stoichiometry: 27.0
species: 626299

880013
type: SpeciesReference
stoichiometry: 455.0
species: 624919

879725
type: SpeciesReference
stoichiometry: 21.0
species: 625867

879965
type: SpeciesReference
stoichiometry: 1.0
species: 641406

879893
type: SpeciesReference
stoichiometry: 16.0
species: 628699

879977
type: SpeciesReference
stoichiometry: 1365.0
species: 624655

879905
type: SpeciesReference
stoichiometry: 15.0
species: 628531

879749
type: SpeciesReference
stoichiometry: 15.0
species: 626575

879869
type: SpeciesReference
stoichiometry: 25.0
species: 626155

879797
type: SpeciesReference
stoichiometry: 22.0
species: 625819

879845
type: SpeciesReference
stoichiometry: 69.0
species: 628075

879917
type: SpeciesReference
stoichiometry: 2.0
species: 626539

879773
type: SpeciesReference
stoichiometry: 6.0
species: 627835

879701
type: SpeciesReference
stoichiometry: 9.0
species: 625675

879821
type: SpeciesReference
stoichiometry: 14.0
species: 626407

661093
type: Constraint
message: Error: Species concentration Glycocholate_b is out of the hard bounds.

672888
type: Constraint
message: Warning: Species concentration Carbonate_c is out of the soft bounds.

638826
type: Species
is: C03242
initial concentration: 2.6E-4
is: http://identifiers.org/cas/1783-84-2
in compartment: 623851
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
name: Dihomo-gamma-linolenate_l
is: http://identifiers.org/pubchem.compound/7850023

674976
type: Constraint
message: Warning: Species concentration sulfochenodeoxycholate_c is out of the soft bounds.

630103
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3622
is: CHEBI:16946
in compartment: 623911
name: Kynurenine_c
is: http://identifiers.org/cas/343-65-7
is: C00328

645461
type: Constraint
message: Warning: Species concentration Alanine_m is out of the soft bounds.

884179
type: Reaction
product: 884452
product: 884504
product: 884374
product: 884426
product: 884348
product: 884231
product: 884413
product: 884322
product: 884478
product: 884335
product: 884296
product: 884244
reactant: 884192
product: 884361
product: 884400
fast: false
product: 884283
reversible: false
reactant: 884218
notes: Protein degradation
product: 884491
product: 884465
name: r2637
product: 884257
product: 884270
product: 884387
product: 884309
product: 884439
reactant: 884205

884452
type: SpeciesReference
stoichiometry: 53.0
species: 628531

884504
type: SpeciesReference
stoichiometry: 562.5
species: 624727

884374
type: SpeciesReference
stoichiometry: 27.0
species: 628147

884426
type: SpeciesReference
stoichiometry: 69.0
species: 626299

884348
type: SpeciesReference
stoichiometry: 66.0
species: 627559

884231
type: SpeciesReference
stoichiometry: 42.0
species: 625675

884413
type: SpeciesReference
stoichiometry: 40.0
species: 626155

884322
type: SpeciesReference
stoichiometry: 61.0
species: 630798

884478
type: SpeciesReference
stoichiometry: 18.0
species: 626695

884335
type: SpeciesReference
stoichiometry: 91.0
species: 625819

884296
type: SpeciesReference
stoichiometry: 211.0
species: 625627

884244
type: SpeciesReference
stoichiometry: 15.0
species: 627007

884192
type: SpeciesReference
stoichiometry: 1.0
species: 641478

884361
type: SpeciesReference
stoichiometry: 14.0
species: 626407

884400
type: SpeciesReference
stoichiometry: 58.0
species: 626251

884283
type: SpeciesReference
stoichiometry: 38.0
species: 626575

884218
type: SpeciesReference
stoichiometry: 562.5
species: 624259

884491
type: SpeciesReference
stoichiometry: 562.5
species: 624655

884465
type: SpeciesReference
stoichiometry: 5.0
species: 626539

884257
type: SpeciesReference
stoichiometry: 63.0
species: 625867

884270
type: SpeciesReference
stoichiometry: 73.0
species: 625291

884387
type: SpeciesReference
stoichiometry: 129.0
species: 628075

884309
type: SpeciesReference
stoichiometry: 7.0
species: 627835

884439
type: SpeciesReference
stoichiometry: 45.0
species: 628699

884205
type: SpeciesReference
stoichiometry: 562.5
species: 624331

666420
type: Constraint
message: Error: Species concentration Formylanthranilate_c is out of the hard bounds.

780942
type: Reaction
reactant: 780966
reversible: true
name: r1556
is: ENSMUSG00000040010
product: 780990
reactant: 780954
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: 780978

780966
type: SpeciesReference
stoichiometry: 1.0
species: 629551

780990
type: SpeciesReference
stoichiometry: 1.0
species: 629563

780954
type: SpeciesReference
stoichiometry: 1.0
species: 625639

780978
type: SpeciesReference
stoichiometry: 1.0
species: 625627

673140
type: Constraint
message: Error: Species concentration 20-hydroxy-arachidonate_s is out of the hard bounds.

660229
type: Constraint
message: Error: Species concentration Na+_c is out of the hard bounds.

755519
type: Reaction
is: ENSMUSG00000020333
is: ENSMUSG00000032281
reactant: 755531
is: ENSMUSG00000031278
product: 755579
is: ENSMUSG00000018796
notes: EC:6.2.1.3
fast: false
reactant: 755555
name: r1257
is: ENSMUSG00000024981
reactant: 755543
is: ENSMUSG00000032883
reversible: false
product: 755591
product: 755567
is: ENSMUSG00000027359
is: ENSMUSG00000024207

755531
type: SpeciesReference
stoichiometry: 1.0
species: 633247

755579
type: SpeciesReference
stoichiometry: 1.0
species: 624907

755555
type: SpeciesReference
stoichiometry: 1.0
species: 624787

755543
type: SpeciesReference
stoichiometry: 1.0
species: 624319

755591
type: SpeciesReference
stoichiometry: 1.0
species: 637339

755567
type: SpeciesReference
stoichiometry: 1.0
species: 625123

731659
type: Reaction
product: 731683
reactant: 731671
notes: Facilitated diffusion
fast: false
reversible: true
name: r0892

731683
type: SpeciesReference
stoichiometry: 1.0
species: 626491

731671
type: SpeciesReference
stoichiometry: 1.0
species: 626479

626479
type: Species
boundary condition: true
name: UTP_c
in compartment: 623911
is: http://identifiers.org/pubchem.compound/3375
initial concentration: 2.6E-4
constant: false
has only substance units: false
is: http://identifiers.org/cas/63-39-8
initial amount: NaN
is: C00075
is: CHEBI:15713

745592
type: Reaction
fast: false
name: r1109
is: K01644
notes: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
product: 745618
reversible: true
is: K01646
is: K01643
reactant: 745605
product: 745631
is: R00362

745618
type: SpeciesReference
stoichiometry: 1.0
species: 625555

745605
type: SpeciesReference
stoichiometry: 1.0
species: 628303

745631
type: SpeciesReference
stoichiometry: 1.0
species: 625615

625615
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3338
name: OAA_m
is: C00036
has only substance units: false
in compartment: 623863
is: CHEBI:30744
initial concentration: 5.05E-5
boundary condition: false
is: http://identifiers.org/cas/328-42-7
constant: false

698764
type: Reaction
is: ENSMUSG00000062070
fast: false
is: ENSMUSG00000031233
product: 698812
is: K00927
notes: ATP:3-phospho-D-glycerate 1-phosphotransferase Glycolysis / Gluconeogenesis EC:2.7.2.3
is: R01512
reactant: 698776
reactant: 698788
product: 698800
name: r0337
reversible: true

698812
type: SpeciesReference
stoichiometry: 1.0
species: 629203

629203
type: Species
initial amount: NaN
is: C00236
constant: false
name: 1,3DPG_c
is: CHEBI:16001
in compartment: 623911
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3535
is: http://identifiers.org/cas/38168-82-0
boundary condition: false
has only substance units: false

698776
type: SpeciesReference
stoichiometry: 1.0
species: 624331

698788
type: SpeciesReference
stoichiometry: 1.0
species: 628795

628795
type: Species
is: http://identifiers.org/pubchem.compound/3497
is: CHEBI:17794
name: 3PG_c
constant: false
initial amount: NaN
in compartment: 623911
has only substance units: false
boundary condition: false
initial concentration: 2.6E-4
is: C00197

698800
type: SpeciesReference
stoichiometry: 1.0
species: 624655

717688
type: Reaction
product: 717748
reversible: true
reactant: 717700
reactant: 717712
is: K10217
is: R03889
notes: 2-Aminomuconate semialdehyde:NAD+ 6-oxidoreductase Tryptophan metabolism EC:1.2.1.32
name: r0645
fast: false
product: 717736
reactant: 717724

717748
type: SpeciesReference
stoichiometry: 1.0
species: 624451

717700
type: SpeciesReference
stoichiometry: 1.0
species: 634459

634459
type: Species
initial amount: NaN
constant: false
is: CHEBI:57495
name: 2-Aminomuconate_semialdehyde_c
is: http://identifiers.org/pubchem.compound/9543252
has only substance units: false
in compartment: 623911
boundary condition: false
initial concentration: 2.6E-4

717712
type: SpeciesReference
stoichiometry: 1.0
species: 624403

717736
type: SpeciesReference
stoichiometry: 1.0
species: 633691

633691
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 2-Aminomuconate_c

717724
type: SpeciesReference
stoichiometry: 1.0
species: 624259

750419
type: Reaction
reversible: false
reactant: 750431
fast: false
is: ENSMUSG00000026818
product: 750455
notes: EC:3.1.1.13
name: r1184
reactant: 750443
product: 750467
is: ENSMUSG00000024781

750431
type: SpeciesReference
stoichiometry: 1.0
species: 624283

750455
type: SpeciesReference
stoichiometry: 1.0
species: 628687

750443
type: SpeciesReference
stoichiometry: 1.0
species: 637926

637926
type: Species
is: http://identifiers.org/pubchem.compound/814273
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623851
name: Cholesterol-ester-arach_l

750467
type: SpeciesReference
stoichiometry: 1.0
species: 629071

629071
type: Species
initial concentration: 2.6E-4
boundary condition: false
is: http://identifiers.org/cas/506-32-1
in compartment: 623851
is: http://identifiers.org/pubchem.compound/3519
is: C00219
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:15843
name: Arachidonate_l

778050
type: Reaction
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
product: 778110
fast: false
is: ENSMUSG00000015243
product: 778122
name: r1517
reactant: 778062
reactant: 778086
reversible: false
product: 778098
reactant: 778074

778110
type: SpeciesReference
stoichiometry: 1.0
species: 624655

778122
type: SpeciesReference
stoichiometry: 1.0
species: 624727

778062
type: SpeciesReference
stoichiometry: 1.0
species: 633211

778086
type: SpeciesReference
stoichiometry: 1.0
species: 624259

778098
type: SpeciesReference
stoichiometry: 1.0
species: 633223

778074
type: SpeciesReference
stoichiometry: 1.0
species: 624331

647293
type: Constraint
message: Error: Species concentration Phenylalanine_m is out of the hard bounds.

747443
type: Reaction
product: 747467
reactant: 747455
notes: Transport reaction
fast: false
reversible: false
name: r1133

747467
type: SpeciesReference
stoichiometry: 1.0
species: 624187

624187
type: Species
is: P02656
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623923
name: ApoC3_r

747455
type: SpeciesReference
stoichiometry: 1.0
species: 624199

624199
type: Species
is: P02656
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: ApoC3_c

628735
type: Species
initial amount: NaN
is: CHEBI:16857
in compartment: 623863
constant: false
is: C00188
is: http://identifiers.org/pubchem.compound/3488
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/72-19-5
name: Threonine_m

739734
type: Reaction
product: 739758
reactant: 739746
notes: Vesicular transport
fast: false
reversible: false
name: r1067

739758
type: SpeciesReference
stoichiometry: 1.0
species: 627835

739746
type: SpeciesReference
stoichiometry: 1.0
species: 627859

627859
type: Species
name: Histidine_l
is: C00135
initial concentration: 2.6E-4
constant: false
is: http://identifiers.org/pubchem.compound/3435
in compartment: 623851
has only substance units: false
boundary condition: false
is: CHEBI:15971
is: http://identifiers.org/cas/71-00-1
initial amount: NaN

893019
type: Reaction
product: 893055
product: 893043
reactant: 893031
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r2666

893055
type: SpeciesReference
stoichiometry: 1.0
species: 641670

641670
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623911
name: UDP-activated-galactose_c

893043
type: SpeciesReference
stoichiometry: 1.0
species: 625027

893031
type: SpeciesReference
stoichiometry: 1.0
species: 625963

625963
type: Species
constant: false
initial concentration: 2.6E-4
has only substance units: false
is: C00052
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3354
name: UDP-galactose_c
boundary condition: true
is: CHEBI:18307

632551
type: Species
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/4269
is: C01024
is: http://identifiers.org/cas/73023-76-4
name: Hydroxymethylbilane_c
initial concentration: 2.6E-4
in compartment: 623911
is: CHEBI:16645

627427
type: Species
is: http://identifiers.org/cas/56-81-5
initial amount: NaN
has only substance units: false
is: C00116
is: CHEBI:17754
name: Glycerol_s
is: http://identifiers.org/pubchem.compound/3416
boundary condition: true
constant: false
in compartment: 623935
initial concentration: 2.6E-4

625231
type: Species
is: http://identifiers.org/cas/127-17-3
is: http://identifiers.org/pubchem.compound/3324
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:32816
is: C00022
in compartment: 623899
constant: false
initial concentration: 0.00155
name: Pyruvate_p

642582
type: Constraint
message: Warning: Species concentration H2O_s is out of the soft bounds.

664621
type: Constraint
message: Error: Species concentration 3-Oxododecanoyl-CoA_p is out of the hard bounds.

887164
type: Reaction
reactant: 887176
product: 887488
reactant: 887344
reactant: 887284
reactant: 887416
fast: false
reactant: 887368
notes: Ficolin-3 Protein assembly
name: r2646
reactant: 887332
reactant: 887404
reactant: 887212
reactant: 887308
reactant: 887380
reactant: 887356
reactant: 887272
reactant: 887428
reactant: 887236
reactant: 887200
product: 887440
reactant: 887296
reversible: false
reactant: 887224
product: 887464
product: 887452
reactant: 887392
reactant: 887248
product: 887476
reactant: 887188
reactant: 887320
reactant: 887260

887176
type: SpeciesReference
stoichiometry: 20.0
species: 625675

887488
type: SpeciesReference
stoichiometry: 299.0
species: 624919

887344
type: SpeciesReference
stoichiometry: 20.0
species: 626155

887284
type: SpeciesReference
stoichiometry: 35.0
species: 627559

887416
type: SpeciesReference
stoichiometry: 1196.0
species: 624331

887368
type: SpeciesReference
stoichiometry: 9.0
species: 628699

887332
type: SpeciesReference
stoichiometry: 10.0
species: 626251

887404
type: SpeciesReference
stoichiometry: 10.0
species: 626695

887212
type: SpeciesReference
stoichiometry: 18.0
species: 625291

887308
type: SpeciesReference
stoichiometry: 12.0
species: 628147

887380
type: SpeciesReference
stoichiometry: 13.0
species: 628531

887356
type: SpeciesReference
stoichiometry: 23.0
species: 626299

887272
type: SpeciesReference
stoichiometry: 7.0
species: 625819

887428
type: SpeciesReference
stoichiometry: 1196.0
species: 624259

887236
type: SpeciesReference
stoichiometry: 38.0
species: 625627

887200
type: SpeciesReference
stoichiometry: 13.0
species: 625867

887440
type: SpeciesReference
stoichiometry: 1.0
species: 641538

887296
type: SpeciesReference
stoichiometry: 5.0
species: 626407

887224
type: SpeciesReference
stoichiometry: 11.0
species: 626575

887464
type: SpeciesReference
stoichiometry: 897.0
species: 624727

887452
type: SpeciesReference
stoichiometry: 897.0
species: 624655

887392
type: SpeciesReference
stoichiometry: 10.0
species: 626539

887248
type: SpeciesReference
stoichiometry: 10.0
species: 627835

887476
type: SpeciesReference
stoichiometry: 299.0
species: 625135

887188
type: SpeciesReference
stoichiometry: 9.0
species: 627007

887320
type: SpeciesReference
stoichiometry: 23.0
species: 628075

887260
type: SpeciesReference
stoichiometry: 3.0
species: 630798

670908
type: Constraint
message: Error: Species concentration Fatty-acid-VLDL-PE-pool_c is out of the hard bounds.

717292
type: Reaction
product: 717340
reactant: 717304
reactant: 717316
notes: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: R03858
fast: false
is: ENSMUSG00000059447
reversible: true
name: r0639
is: K07513
product: 717328
is: K00632
is: K07509
is: K07508
is: ENSMUSG00000036880

717340
type: SpeciesReference
stoichiometry: 1.0
species: 635215

635215
type: Species
in compartment: 623863
is: CHEBI:28726
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/7648
is: C05261
name: 3-Oxotetradecanoyl-CoA_m
initial concentration: 1.0E-5
initial amount: NaN
has only substance units: false

717304
type: SpeciesReference
stoichiometry: 1.0
species: 633475

633475
type: Species
initial concentration: 2.6E-4
constant: false
is: http://identifiers.org/cas/6244-92-4
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/4951
is: C01832
initial amount: NaN
in compartment: 623863
is: CHEBI:15521
name: Lauroyl-CoA_m

717316
type: SpeciesReference
stoichiometry: 1.0
species: 625267

717328
type: SpeciesReference
stoichiometry: 1.0
species: 624811

756143
type: Reaction
product: 756167
reactant: 756155
notes: Transport reaction
fast: false
reversible: false
name: r1265

756167
type: SpeciesReference
stoichiometry: 1.0
species: 638310

756155
type: SpeciesReference
stoichiometry: 1.0
species: 638334

638334
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623851
name: Triacylglycerol-VLDL-pool_l

647342
type: Constraint
message: Error: Species concentration H+(PG)_s is out of the hard bounds.

668532
type: Constraint
message: Error: Species concentration VLDL_l is out of the hard bounds.

658562
type: Constraint
message: Warning: Species concentration Sphinganine_c is out of the soft bounds.

693413
type: Reaction
name: r0250
fast: false
is: ENSMUSG00000053604
reactant: 693425
product: 693437
is: K01808
reversible: true
notes: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
is: R01056
is: K01807

693425
type: SpeciesReference
stoichiometry: 1.0
species: 627463

693437
type: SpeciesReference
stoichiometry: 1.0
species: 628831

630559
type: Species
is: C00365
has only substance units: false
constant: false
is: CHEBI:17622
boundary condition: false
in compartment: 623863
name: dUMP_m
is: http://identifiers.org/cas/964-26-1
initial concentration: 2.6E-4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3656

711245
type: Reaction
reactant: 711257
product: 711281
is: R02466
is: K01594
reversible: true
fast: false
is: K01580
name: r0538
is: ENSMUSG00000023044
is: ENSMUSG00000026787
notes: 3-Sulfino-L-alanine carboxy-lyase Taurine and hypotaurine metabolism EC:4.1.1.29
product: 711269
is: ENSMUSG00000070880

711257
type: SpeciesReference
stoichiometry: 1.0
species: 631722

711281
type: SpeciesReference
stoichiometry: 1.0
species: 631374

711269
type: SpeciesReference
stoichiometry: 1.0
species: 624859

663049
type: Constraint
message: Warning: Species concentration 1-Pyrroline-5-carboxylate_c is out of the soft bounds.

663241
type: Constraint
message: Warning: Species concentration 6-Lactoyl-5,6,7,8-tetrahydropterin_c is out of the soft bounds.

813097
type: Reaction
reactant: 813109
product: 813169
name: r1971
product: 813145
reversible: false
notes: Y+LAT2 Utilized transport
fast: false
product: 813157
reactant: 813121
is: ENSMUSG00000031904
reactant: 813133

813109
type: SpeciesReference
stoichiometry: 1.0
species: 628159

813169
type: SpeciesReference
stoichiometry: 1.0
species: 630079

813145
type: SpeciesReference
stoichiometry: 1.0
species: 628147

813157
type: SpeciesReference
stoichiometry: 1.0
species: 633079

813121
type: SpeciesReference
stoichiometry: 1.0
species: 633091

813133
type: SpeciesReference
stoichiometry: 1.0
species: 630067

665869
type: Constraint
message: Error: Species concentration 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA_p is out of the hard bounds.

651098
type: Constraint
message: Warning: Species concentration Thymine_m is out of the soft bounds.

645797
type: Constraint
message: Warning: Species concentration Aspartate_s is out of the soft bounds.

666588
type: Constraint
message: Error: Species concentration (2E)-Hexenoyl-ACP_c is out of the hard bounds.

674208
type: Constraint
message: Warning: Species concentration prostaglandin-b1_c is out of the soft bounds.

650630
type: Constraint
message: Error: Species concentration Citrate_c is out of the hard bounds.

730435
type: Reaction
product: 730459
reactant: 730447
notes: Facilitated diffusion
fast: false
reversible: true
name: r0870

730459
type: SpeciesReference
stoichiometry: 1.0
species: 625051

730447
type: SpeciesReference
stoichiometry: 1.0
species: 625063

625063
type: Species
is: http://identifiers.org/cas/146-14-5
is: CHEBI:16238
has only substance units: false
name: FAD_s
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3318
in compartment: 623935
boundary condition: true
initial concentration: 2.6E-4
is: C00016
constant: false

840396
type: Reaction
product: 840420
reactant: 840408
notes: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
name: r2341

840420
type: SpeciesReference
stoichiometry: 1.0
species: 633607

840408
type: SpeciesReference
stoichiometry: 1.0
species: 633619

633619
type: Species
in compartment: 623935
is: C02166
initial amount: NaN
is: CHEBI:16978
boundary condition: true
is: http://identifiers.org/cas/72025-60-6
has only substance units: false
constant: false
name: Leukotriene_C4_s
is: http://identifiers.org/pubchem.compound/5241
initial concentration: 2.6E-4

820800
type: Reaction
reversible: true
is: ENSMUSG00000032902
reactant: 820824
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: 820812
product: 820848
name: r2091
product: 820836

820824
type: SpeciesReference
stoichiometry: 1.0
species: 629335

629335
type: Species
is: CHEBI:30772
has only substance units: false
is: http://identifiers.org/pubchem.compound/3545
initial concentration: 2.6E-4
constant: false
in compartment: 623935
name: Butyrate_s
is: C00246
initial amount: NaN
boundary condition: true
is: http://identifiers.org/cas/107-92-6

820812
type: SpeciesReference
stoichiometry: 1.0
species: 636643

820848
type: SpeciesReference
stoichiometry: 1.0
species: 629323

629323
type: Species
boundary condition: false
name: Butyrate_c
constant: false
in compartment: 623911
is: C00246
is: http://identifiers.org/cas/107-92-6
initial amount: NaN
is: CHEBI:30772
is: http://identifiers.org/pubchem.compound/3545
initial concentration: 2.6E-4
has only substance units: false

820836
type: SpeciesReference
stoichiometry: 1.0
species: 636655

708654
type: Reaction
product: 708702
is: ENSMUSG00000048120
name: r0497
reactant: 708678
notes: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is: K01510
reversible: true
is: R02095
is: ENSMUSG00000041608
reactant: 708666
fast: false
is: ENSMUSG00000036813
product: 708690

708702
type: SpeciesReference
stoichiometry: 1.0
species: 624739

708678
type: SpeciesReference
stoichiometry: 1.0
species: 624271

708666
type: SpeciesReference
stoichiometry: 1.0
species: 631122

631122
type: Species
is: http://identifiers.org/pubchem.compound/3743
constant: false
initial concentration: 2.6E-4
initial amount: NaN
name: dTTP_s
boundary condition: true
has only substance units: false
in compartment: 623935
is: CHEBI:18077
is: C00459

708690
type: SpeciesReference
stoichiometry: 1.0
species: 630499

630499
type: Species
boundary condition: true
initial concentration: 2.6E-4
name: dTDP_s
is: CHEBI:18075
has only substance units: false
constant: false
is: C00363
is: http://identifiers.org/pubchem.compound/3654
initial amount: NaN
in compartment: 623935

828815
type: Reaction
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: 828863
name: r2201
reactant: 828827
is: ENSMUSG00000030236
reactant: 828839
product: 828887
product: 828875
reversible: true
reactant: 828851
fast: false

828863
type: SpeciesReference
stoichiometry: 1.0
species: 639618

639618
type: Species
initial concentration: 2.6E-4
has only substance units: false
name: leukotriene-e4_c
initial amount: NaN
is: http://identifiers.org/pubchem.compound/8236
in compartment: 623911
is: CHEBI:15650
is: C05952
boundary condition: false
constant: false

828827
type: SpeciesReference
stoichiometry: 1.0
species: 639630

639630
type: Species
initial amount: NaN
is: CHEBI:15650
in compartment: 623935
boundary condition: false
name: leukotriene-e4_s
is: C05952
is: http://identifiers.org/pubchem.compound/8236
constant: false
initial concentration: 2.6E-4
has only substance units: false

828839
type: SpeciesReference
stoichiometry: 1.0
species: 629719

828887
type: SpeciesReference
stoichiometry: 1.0
species: 625927

828875
type: SpeciesReference
stoichiometry: 1.0
species: 629731

828851
type: SpeciesReference
stoichiometry: 1.0
species: 625915

818880
type: Reaction
product: 818916
reversible: false
reactant: 818892
fast: false
name: r2059
reactant: 818904
is: ENSMUSG00000030492
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: 818928

818916
type: SpeciesReference
stoichiometry: 1.0
species: 630067

818892
type: SpeciesReference
stoichiometry: 1.0
species: 630079

818904
type: SpeciesReference
stoichiometry: 1.0
species: 626299

818928
type: SpeciesReference
stoichiometry: 1.0
species: 626311

654578
type: Constraint
message: Warning: Species concentration Geranyl-PP_p is out of the soft bounds.

790529
type: Reaction
is: ENSMUSG00000031904
reactant: 790541
reactant: 790553
reactant: 790565
notes: Y+LAT2 Utilized transport
name: r1703
reversible: false
product: 790601
fast: false
product: 790577
product: 790589

790541
type: SpeciesReference
stoichiometry: 1.0
species: 626263

790553
type: SpeciesReference
stoichiometry: 1.0
species: 625675

790565
type: SpeciesReference
stoichiometry: 1.0
species: 633091

790601
type: SpeciesReference
stoichiometry: 1.0
species: 633079

790577
type: SpeciesReference
stoichiometry: 1.0
species: 626251

790589
type: SpeciesReference
stoichiometry: 1.0
species: 625687

756575
type: Reaction
is: ENSMUSG00000056220
product: 756611
is: ENSMUSG00000028749
is: ENSMUSG00000034579
is: ENSMUSG00000028750
fast: false
is: ENSMUSG00000028751
is: ENSMUSG00000042632
reversible: true
reactant: 756587
is: K01047
is: ENSMUSG00000041193
is: ENSMUSG00000070719
is: ENSMUSG00000029522
product: 756623
is: R01315
is: ENSMUSG00000050211
is: ENSMUSG00000009646
is: ENSMUSG00000033852
is: ENSMUSG00000041202
reactant: 756599
name: r1277
notes: Phosphatidylcholine 2-acylhydrolase Glycerophospholipid metabolism EC:3.1.1.4
is: ENSMUSG00000027999
is: ENSMUSG00000022683

756611
type: SpeciesReference
stoichiometry: 1.0
species: 637747

756587
type: SpeciesReference
stoichiometry: 1.0
species: 637483

756623
type: SpeciesReference
stoichiometry: 1.0
species: 638382

638382
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: Fatty-acid-VLDL-PC-pool_r

756599
type: SpeciesReference
stoichiometry: 1.0
species: 624247

690713
type: Reaction
is: K00971
product: 690749
is: R00883
name: r0207
product: 690761
notes: GDP:D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.22
reactant: 690737
reversible: true
reactant: 690725
fast: false

690749
type: SpeciesReference
stoichiometry: 1.0
species: 624727

690761
type: SpeciesReference
stoichiometry: 1.0
species: 626995

626995
type: Species
constant: false
boundary condition: true
is: C00096
name: GDP-mannose_c
initial amount: NaN
is: CHEBI:15820
is: http://identifiers.org/pubchem.compound/3396
in compartment: 623911
has only substance units: false
initial concentration: 2.6E-4

690737
type: SpeciesReference
stoichiometry: 1.0
species: 631806

631806
type: Species
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3909
initial amount: NaN
in compartment: 623911
name: Mannose-1P_c
constant: false
has only substance units: false
is: CHEBI:35374
is: C00636
boundary condition: false

690725
type: SpeciesReference
stoichiometry: 1.0
species: 625567

666984
type: Constraint
message: Warning: Species concentration Hexadecanoyl-ACP_c is out of the soft bounds.

656498
type: Constraint
message: Warning: Species concentration Cytidine_c is out of the soft bounds.

675120
type: Constraint
message: Warning: Species concentration mitoOxidizedThioredoxin_m is out of the soft bounds.

670872
type: Constraint
message: Warning: Species concentration Fatty-acid-VLDL-PC-pool_c is out of the soft bounds.

654794
type: Constraint
message: Warning: Species concentration Fructose-1,6PP_c is out of the soft bounds.

653738
type: Constraint
message: Warning: Species concentration Creatine_c is out of the soft bounds.

797332
type: Reaction
product: 797392
is: ENSMUSG00000031904
product: 797380
reactant: 797344
reactant: 797356
reversible: false
product: 797404
fast: false
reactant: 797368
notes: Y+LAT2 Utilized transport
name: r1784

797392
type: SpeciesReference
stoichiometry: 1.0
species: 627019

797380
type: SpeciesReference
stoichiometry: 1.0
species: 626695

797344
type: SpeciesReference
stoichiometry: 1.0
species: 626707

797356
type: SpeciesReference
stoichiometry: 1.0
species: 627007

797404
type: SpeciesReference
stoichiometry: 1.0
species: 633079

797368
type: SpeciesReference
stoichiometry: 1.0
species: 633091

702735
type: Reaction
product: 702771
reactant: 702759
reversible: true
fast: false
is: K00072
name: r0402
notes: Tetrahydrobiopterin:NADP+ oxidoreductase Folate biosynthesis EC:1.1.1.153
reactant: 702747
is: R01813
product: 702783
is: ENSMUSG00000033735

702771
type: SpeciesReference
stoichiometry: 1.0
species: 624499

702759
type: SpeciesReference
stoichiometry: 1.0
species: 624547

702747
type: SpeciesReference
stoichiometry: 1.0
species: 629611

702783
type: SpeciesReference
stoichiometry: 1.0
species: 634579

634579
type: Species
is: C04244
is: CHEBI:17248
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6909
boundary condition: false
name: 6-Lactoyl-5,6,7,8-tetrahydropterin_c
has only substance units: false
initial concentration: 2.6E-4
constant: false

801784
type: Reaction
fast: false
name: r1837
reactant: 801796
reversible: false
notes: Y+LAT2 Utilized transport
reactant: 801820
product: 801844
is: ENSMUSG00000031904
product: 801856
reactant: 801808
product: 801832

801796
type: SpeciesReference
stoichiometry: 1.0
species: 628159

801820
type: SpeciesReference
stoichiometry: 1.0
species: 633091

801844
type: SpeciesReference
stoichiometry: 1.0
species: 625639

801856
type: SpeciesReference
stoichiometry: 1.0
species: 633079

801808
type: SpeciesReference
stoichiometry: 1.0
species: 625627

801832
type: SpeciesReference
stoichiometry: 1.0
species: 628147

796912
type: Reaction
name: r1779
product: 796960
reversible: false
product: 796984
product: 796972
notes: Y+LAT2 Utilized transport
fast: false
reactant: 796924
reactant: 796936
is: ENSMUSG00000031904
reactant: 796948

796960
type: SpeciesReference
stoichiometry: 1.0
species: 626695

796984
type: SpeciesReference
stoichiometry: 1.0
species: 633079

796972
type: SpeciesReference
stoichiometry: 1.0
species: 626263

796924
type: SpeciesReference
stoichiometry: 1.0
species: 626707

796936
type: SpeciesReference
stoichiometry: 1.0
species: 626251

796948
type: SpeciesReference
stoichiometry: 1.0
species: 633091

817200
type: Reaction
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
product: 817236
fast: false
name: r2031
reactant: 817212
product: 817248
is: ENSMUSG00000030492
reactant: 817224

817236
type: SpeciesReference
stoichiometry: 1.0
species: 626503

817212
type: SpeciesReference
stoichiometry: 1.0
species: 626515

817248
type: SpeciesReference
stoichiometry: 1.0
species: 626707

817224
type: SpeciesReference
stoichiometry: 1.0
species: 626695

668580
type: Constraint
message: Error: Species concentration Cholesterol-ester-pool_l is out of the hard bounds.

774427
type: Reaction
product: 774451
reactant: 774439
notes: Transport reaction
fast: false
reversible: true
name: r1462

774451
type: SpeciesReference
stoichiometry: 1.0
species: 629599

629599
type: Species
has only substance units: false
name: N-Acetylneuraminate_n
is: C00270
is: http://identifiers.org/pubchem.compound/3568
constant: false
is: http://identifiers.org/cas/131-48-6
initial concentration: 2.6E-4
boundary condition: false
initial amount: NaN
in compartment: 623875
is: CHEBI:17012

774439
type: SpeciesReference
stoichiometry: 1.0
species: 629587

849491
type: Reaction
name: r2491
reactant: 849503
reactant: 849515
product: 849539
is: ENSMUSG00000030237
product: 849551
reactant: 849527
fast: false
product: 849563
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000041698
reversible: true
is: ENSMUSG00000079262
is: ENSMUSG00000063975

849503
type: SpeciesReference
stoichiometry: 1.0
species: 633583

849515
type: SpeciesReference
stoichiometry: 1.0
species: 629707

629707
type: Species
initial amount: NaN
boundary condition: true
is: CHEBI:17544
constant: false
name: HCO3-_b
is: C00288
has only substance units: false
in compartment: 623887
initial concentration: 0.0026
is: http://identifiers.org/pubchem.compound/3583

849539
type: SpeciesReference
stoichiometry: 1.0
species: 633571

849551
type: SpeciesReference
stoichiometry: 1.0
species: 629719

849527
type: SpeciesReference
stoichiometry: 1.0
species: 639906

639906
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623887
name: glutathionyl-leuc4_b

849563
type: SpeciesReference
stoichiometry: 1.0
species: 639918

674772
type: Constraint
message: Error: Species concentration prostaglandin-f2beta_c is out of the hard bounds.

658430
type: Constraint
message: Error: Species concentration Serotonin_c is out of the hard bounds.

653102
type: Constraint
message: Error: Species concentration Glycerate_m is out of the hard bounds.

727040
type: Reaction
product: 727076
notes: glycine N-choloyltransferase EC:2.3.1.65
is: R08745
product: 727088
name: r0798
is: K00659
reactant: 727052
is: ENSMUSG00000039653
reactant: 727064
reversible: true
fast: false

727076
type: SpeciesReference
stoichiometry: 1.0
species: 624799

727088
type: SpeciesReference
stoichiometry: 1.0
species: 635923

727052
type: SpeciesReference
stoichiometry: 1.0
species: 635551

727064
type: SpeciesReference
stoichiometry: 1.0
species: 629287

713969
type: Reaction
fast: false
is: ENSMUSG00000009905
reversible: true
notes: Sphinganine:NADP+ 3-oxidoreductase Sphingolipid metabolism EC:1.1.1.102
is: R02978
product: 714017
product: 714005
reactant: 713981
name: r0583
reactant: 713993
is: K04708

714017
type: SpeciesReference
stoichiometry: 1.0
species: 624499

714005
type: SpeciesReference
stoichiometry: 1.0
species: 633979

713981
type: SpeciesReference
stoichiometry: 1.0
species: 632239

632239
type: Species
is: C00836
name: Sphinganine_c
boundary condition: false
is: http://identifiers.org/cas/764-22-7
in compartment: 623911
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:16566
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/4094

713993
type: SpeciesReference
stoichiometry: 1.0
species: 624547

783042
type: Reaction
fast: false
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: 783078
is: ENSMUSG00000040010
reactant: 783066
product: 783090
name: r1591
reactant: 783054

783078
type: SpeciesReference
stoichiometry: 1.0
species: 626299

783066
type: SpeciesReference
stoichiometry: 1.0
species: 628075

783090
type: SpeciesReference
stoichiometry: 1.0
species: 628087

783054
type: SpeciesReference
stoichiometry: 1.0
species: 626311

647870
type: Constraint
message: Error: Species concentration Glucose-6P_c is out of the hard bounds.

665881
type: Constraint
message: Warning: Species concentration 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA_p is out of the soft bounds.

716200
type: Reaction
is: K01835
is: ENSMUSG00000025791
notes: alpha-D-Glucose 1-phosphate 1,6-phosphomutase Glycolysis / Gluconeogenesis / Starch and sucrose metabolism EC:5.4.2.2 EC:5.4.2.6
fast: false
product: 716224
is: R00959
name: r0621
reversible: true
is: ENSMUSG00000029171
reactant: 716212

716224
type: SpeciesReference
stoichiometry: 1.0
species: 626899

716212
type: SpeciesReference
stoichiometry: 1.0
species: 627151

627151
type: Species
is: http://identifiers.org/pubchem.compound/3403
constant: false
in compartment: 623911
is: http://identifiers.org/cas/59-56-3
initial concentration: 2.6E-4
initial amount: NaN
is: C00103
has only substance units: false
boundary condition: false
is: CHEBI:16077
name: Glucose-1P_c

642906
type: Constraint
message: Error: Species concentration NADH_r is out of the hard bounds.

676475
type: Constraint
message: Error: Species concentration Collagen_CO8A2_c is out of the hard bounds.

665737
type: Constraint
message: Warning: Species concentration 3alpha,7alpha,12alpha-Trihydroxycoprostane_c is out of the soft bounds.

657710
type: Constraint
message: Error: Species concentration 5-Hydroxy-L-tryptophan_c is out of the hard bounds.

674220
type: Constraint
message: Error: Species concentration prostaglandin-b1_s is out of the hard bounds.

740382
type: Reaction
product: 740406
reactant: 740394
notes: Spontaneous reaction
fast: false
reversible: true
name: r1085

740406
type: SpeciesReference
stoichiometry: 1.0
species: 624979

740394
type: SpeciesReference
stoichiometry: 1.0
species: 633103

633103
type: Species
is: C01342
in compartment: 623911
has only substance units: false
initial concentration: 5.25E-4
constant: false
boundary condition: false
is: CHEBI:28938
initial amount: NaN
name: NH4+_c
is: http://identifiers.org/pubchem.compound/4547

701548
type: Reaction
reactant: 701572
is: ENSMUSG00000020456
product: 701596
product: 701584
notes: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
reactant: 701560
reversible: false
is: R01700
name: r0384
fast: false

701572
type: SpeciesReference
stoichiometry: 1.0
species: 629347

701596
type: SpeciesReference
stoichiometry: 1.0
species: 624883

701584
type: SpeciesReference
stoichiometry: 1.0
species: 632875

701560
type: SpeciesReference
stoichiometry: 1.0
species: 625363

798592
type: Reaction
reactant: 798628
product: 798652
fast: false
reactant: 798604
reversible: false
product: 798664
is: ENSMUSG00000031904
product: 798640
notes: Y+LAT2 Utilized transport
name: r1799
reactant: 798616

798628
type: SpeciesReference
stoichiometry: 1.0
species: 633091

798652
type: SpeciesReference
stoichiometry: 1.0
species: 626707

798604
type: SpeciesReference
stoichiometry: 1.0
species: 627019

798664
type: SpeciesReference
stoichiometry: 1.0
species: 633079

798640
type: SpeciesReference
stoichiometry: 1.0
species: 627007

798616
type: SpeciesReference
stoichiometry: 1.0
species: 626695

793385
type: Reaction
product: 793457
reactant: 793421
product: 793433
product: 793445
reactant: 793409
fast: false
name: r1737
notes: Y+LAT2 Utilized transport
is: ENSMUSG00000031904
reactant: 793397
reversible: false

793457
type: SpeciesReference
stoichiometry: 1.0
species: 633079

793421
type: SpeciesReference
stoichiometry: 1.0
species: 633091

793433
type: SpeciesReference
stoichiometry: 1.0
species: 626407

793445
type: SpeciesReference
stoichiometry: 1.0
species: 626587

793409
type: SpeciesReference
stoichiometry: 1.0
species: 626575

793397
type: SpeciesReference
stoichiometry: 1.0
species: 626419

659761
type: Constraint
message: Warning: Species concentration trans-4-Hydroxy-L-proline_m is out of the soft bounds.

624523
type: Species
is: http://identifiers.org/cas/2646-71-1
initial concentration: 5.1E-5
name: NADPH_p
in compartment: 623899
is: C00005
is: CHEBI:16474
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3307
has only substance units: false
constant: false

643458
type: Constraint
message: Error: Species concentration Pi_r is out of the hard bounds.

673260
type: Constraint
message: Error: Species concentration leukotriene-b4_c is out of the hard bounds.

638142
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Acyl-CoA-VLDL-SM-pool_c

713633
type: Reaction
fast: false
is: R02914
reactant: 713645
reversible: true
name: r0577
is: K01712
product: 713657
product: 713669
is: ENSMUSG00000034456
notes: 4,5-Dihydro-4-oxo-5-imidazolepropanoate hydro-lyase Histidine metabolism EC:4.2.1.49

713645
type: SpeciesReference
stoichiometry: 1.0
species: 634339

713657
type: SpeciesReference
stoichiometry: 1.0
species: 632203

713669
type: SpeciesReference
stoichiometry: 1.0
species: 624259

771751
type: Reaction
reactant: 771775
is: R03355
fast: false
reversible: true
is: ENSMUSG00000045594
product: 771799
is: K01190
product: 771787
reactant: 771763
is: K12309
name: r1410
notes: beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase Sphingolipid metabolism EC:3.2.1.23

771775
type: SpeciesReference
stoichiometry: 1.0
species: 624271

771799
type: SpeciesReference
stoichiometry: 1.0
species: 637699

637699
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623935
name: Glucosylceramide-pool_s

771787
type: SpeciesReference
stoichiometry: 1.0
species: 627619

771763
type: SpeciesReference
stoichiometry: 1.0
species: 639378

639378
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623935
name: LacCer-pool_s

660349
type: Constraint
message: Error: Species concentration dUDP_m is out of the hard bounds.

629815
type: Species
is: http://identifiers.org/cas/58-96-8
is: C00299
boundary condition: true
is: http://identifiers.org/pubchem.compound/3593
has only substance units: false
name: Uridine_s
initial amount: NaN
is: CHEBI:16704
constant: false
initial concentration: 2.6E-4
in compartment: 623935

660601
type: Constraint
message: Warning: Species concentration Linoleate_c is out of the soft bounds.

676871
type: Constraint
message: Warning: Species concentration Collagen_COLA1_c is out of the soft bounds.

803127
type: Reaction
reversible: false
reactant: 803139
is: ENSMUSG00000031904
name: r1853
product: 803187
fast: false
product: 803175
reactant: 803163
reactant: 803151
notes: Y+LAT2 Utilized transport
product: 803199

803139
type: SpeciesReference
stoichiometry: 1.0
species: 628543

803187
type: SpeciesReference
stoichiometry: 1.0
species: 625687

803175
type: SpeciesReference
stoichiometry: 1.0
species: 628531

803163
type: SpeciesReference
stoichiometry: 1.0
species: 633091

803151
type: SpeciesReference
stoichiometry: 1.0
species: 625675

803199
type: SpeciesReference
stoichiometry: 1.0
species: 633079

670500
type: Constraint
message: Error: Species concentration Phosphatidate-VLDL-SM-pool_c is out of the hard bounds.

641022
type: Species
is: P08572
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CO4A2_c

875153
type: Reaction
reactant: 875393
is: ENSMUSG00000028339
product: 875441
name: r2610
reactant: 875285
reactant: 875345
reactant: 875321
reactant: 875417
reactant: 875237
product: 875429
reactant: 875165
reactant: 875381
reactant: 875309
reversible: false
reactant: 875201
reactant: 875369
reactant: 875189
reactant: 875333
reactant: 875405
reactant: 875249
reactant: 875225
product: 875465
reactant: 875297
reactant: 875273
fast: false
product: 875453
notes: Collagen alpha-1(XV) chain Protein assembly
reactant: 875261
reactant: 875357
reactant: 875213
product: 875477
reactant: 875177

875393
type: SpeciesReference
stoichiometry: 14.0
species: 626695

875441
type: SpeciesReference
stoichiometry: 4164.0
species: 624655

875285
type: SpeciesReference
stoichiometry: 30.0
species: 626407

875345
type: SpeciesReference
stoichiometry: 99.0
species: 626299

875321
type: SpeciesReference
stoichiometry: 40.0
species: 626251

875417
type: SpeciesReference
stoichiometry: 5552.0
species: 624259

875237
type: SpeciesReference
stoichiometry: 25.0
species: 627835

875429
type: SpeciesReference
stoichiometry: 1.0
species: 641322

641322
type: Species
is: P39059
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_COFA1_c

875165
type: SpeciesReference
stoichiometry: 108.0
species: 625675

875381
type: SpeciesReference
stoichiometry: 10.0
species: 626539

875309
type: SpeciesReference
stoichiometry: 191.0
species: 628075

875201
type: SpeciesReference
stoichiometry: 97.0
species: 625291

875369
type: SpeciesReference
stoichiometry: 65.0
species: 628531

875189
type: SpeciesReference
stoichiometry: 58.0
species: 625867

875333
type: SpeciesReference
stoichiometry: 47.0
species: 626155

875405
type: SpeciesReference
stoichiometry: 5552.0
species: 624331

875249
type: SpeciesReference
stoichiometry: 54.0
species: 630798

875225
type: SpeciesReference
stoichiometry: 221.0
species: 625627

875465
type: SpeciesReference
stoichiometry: 1388.0
species: 625135

875297
type: SpeciesReference
stoichiometry: 38.0
species: 628147

875273
type: SpeciesReference
stoichiometry: 112.0
species: 627559

875453
type: SpeciesReference
stoichiometry: 4164.0
species: 624727

875261
type: SpeciesReference
stoichiometry: 52.0
species: 625819

875357
type: SpeciesReference
stoichiometry: 74.0
species: 628699

875213
type: SpeciesReference
stoichiometry: 43.0
species: 626575

875477
type: SpeciesReference
stoichiometry: 1388.0
species: 624919

875177
type: SpeciesReference
stoichiometry: 10.0
species: 627007

774859
type: Reaction
reactant: 774871
name: r1469
notes: Linoleoyl-CoA, hydrogen-donor:oxygen oxidoreductase Polyunsaturated fatty acid biosynthesis EC:1.14.19.3
product: 774931
is: K10224
reversible: true
product: 774907
fast: false
is: R03814
reactant: 774883
is: ENSMUSG00000010663
product: 774919
reactant: 774895

774871
type: SpeciesReference
stoichiometry: 1.0
species: 637351

774931
type: SpeciesReference
stoichiometry: 1.0
species: 624403

774907
type: SpeciesReference
stoichiometry: 1.0
species: 637399

637399
type: Species
is: C03035
initial amount: NaN
is: CHEBI:15508
name: gamma-Linolenoyl-CoA_c
is: http://identifiers.org/pubchem.compound/5940
boundary condition: false
has only substance units: false
in compartment: 623911
initial concentration: 2.6E-4
constant: false

774883
type: SpeciesReference
stoichiometry: 1.0
species: 624451

774919
type: SpeciesReference
stoichiometry: 1.0
species: 624259

774895
type: SpeciesReference
stoichiometry: 1.0
species: 624595

633559
type: Species
boundary condition: false
is: CHEBI:15533
is: http://identifiers.org/pubchem.compound/5048
name: Octanoyl-CoA_p
initial amount: NaN
initial concentration: 2.6E-4
constant: false
has only substance units: false
in compartment: 623899
is: C01944

664993
type: Constraint
message: Warning: Species concentration (2E)-Tetradecenoyl-CoA_m is out of the soft bounds.

719536
type: Reaction
reactant: 719560
is: ENSMUSG00000020250
is: ENSMUSG00000075704
name: r0675
product: 719572
is: ENSMUSG00000000811
is: R04293
fast: false
notes: Tryptophan metabolism EC:1.8.1.9
reversible: true
reactant: 719548

719560
type: SpeciesReference
stoichiometry: 1.0
species: 624259

719572
type: SpeciesReference
stoichiometry: 1.0
species: 634699

634699
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280673
name: 2-Amino-3-carboxymuconate_semialdehyde_c
initial concentration: 2.6E-4
is: CHEBI:995
in compartment: 623911
boundary condition: false
initial amount: NaN
constant: false

719548
type: SpeciesReference
stoichiometry: 1.0
species: 634387

634387
type: Species
in compartment: 623911
is: C03722
is: CHEBI:16675
constant: false
is: http://identifiers.org/pubchem.compound/6487
boundary condition: false
is: http://identifiers.org/cas/89-00-9
initial concentration: 2.6E-4
initial amount: NaN
name: Quinolinate_c
has only substance units: false

635947
type: Species
initial amount: NaN
name: Taurochenodeoxycholate_p
is: http://identifiers.org/cas/516-35-8
is: C05465
is: http://identifiers.org/pubchem.compound/7825
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:16525
initial concentration: 2.6E-4
in compartment: 623899

770623
type: Reaction
product: 770671
product: 770659
reactant: 770647
reactant: 770636
notes: Active transport
fast: false
reversible: false
name: r1400

770671
type: SpeciesReference
stoichiometry: 1.0
species: 629983

770659
type: SpeciesReference
stoichiometry: 1.0
species: 627103

770647
type: SpeciesReference
stoichiometry: 1.0
species: 629995

770636
type: SpeciesReference
stoichiometry: 1.0
species: 627091

675923
type: Constraint
message: Error: Species concentration Collagen_C43BP_c is out of the hard bounds.

834337
type: Reaction
reactant: 834349
product: 834409
reactant: 834373
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
reactant: 834361
product: 834385
product: 834397
is: ENSMUSG00000030236
reversible: true
name: r2266

834349
type: SpeciesReference
stoichiometry: 1.0
species: 640098

640098
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: prostaglandin-b2_s
constant: false
in compartment: 623935
is: CHEBI:28099
is: http://identifiers.org/cas/13367-85-6
is: C05954
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/8238

834409
type: SpeciesReference
stoichiometry: 1.0
species: 639930

834373
type: SpeciesReference
stoichiometry: 1.0
species: 639918

834361
type: SpeciesReference
stoichiometry: 1.0
species: 629719

834385
type: SpeciesReference
stoichiometry: 1.0
species: 640086

640086
type: Species
in compartment: 623911
constant: false
is: CHEBI:28099
name: prostaglandin-b2_c
is: C05954
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/8238
boundary condition: false
is: http://identifiers.org/cas/13367-85-6
initial amount: NaN
has only substance units: false

834397
type: SpeciesReference
stoichiometry: 1.0
species: 629731

636703
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 2,5-Diamino-6-(5-triphosphoryl-3,4-trihydroxy-2-oxopentyl)-_amino-4-oxopyrimidine_c

668028
type: Constraint
message: Error: Species concentration Fe3+_s is out of the hard bounds.

637950
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1-Acylglycerol-3P-palmn_c

786666
type: Reaction
fast: false
name: r1651
is: ENSMUSG00000040010
product: 786714
reactant: 786678
reactant: 786690
reversible: true
product: 786702
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

786714
type: SpeciesReference
stoichiometry: 1.0
species: 629563

786678
type: SpeciesReference
stoichiometry: 1.0
species: 628087

786690
type: SpeciesReference
stoichiometry: 1.0
species: 629551

786702
type: SpeciesReference
stoichiometry: 1.0
species: 628075

646796
type: Constraint
message: Warning: Species concentration Thiamin-PP_m is out of the soft bounds.

674028
type: Constraint
message: Error: Species concentration S-glutathionyl-ethacrynic-acid_b is out of the hard bounds.

684473
type: Reaction
product: 684533
name: r0107
is: R00351
product: 684509
reactant: 684485
product: 684521
is: K01647
notes: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -> acetyl-CoA) Citrate cycle (TCA cycle) EC:2.3.3.3
is: ENSMUSG00000005683
reversible: true
reactant: 684497
fast: false

684533
type: SpeciesReference
stoichiometry: 1.0
species: 625615

684509
type: SpeciesReference
stoichiometry: 1.0
species: 625267

684485
type: SpeciesReference
stoichiometry: 1.0
species: 628303

684521
type: SpeciesReference
stoichiometry: 1.0
species: 624295

684497
type: SpeciesReference
stoichiometry: 1.0
species: 624811

674640
type: Constraint
message: Warning: Species concentration prostaglandin-e3_c is out of the soft bounds.

661921
type: Constraint
message: Warning: Species concentration 3-Ureidopropionate_c is out of the soft bounds.

848987
type: Reaction
reactant: 849011
reactant: 849023
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000079262
reversible: true
is: ENSMUSG00000063975
is: ENSMUSG00000030237
product: 849035
is: ENSMUSG00000041698
fast: false
reactant: 848999
name: r2485
product: 849059
product: 849047

849011
type: SpeciesReference
stoichiometry: 1.0
species: 629707

849023
type: SpeciesReference
stoichiometry: 1.0
species: 639906

849035
type: SpeciesReference
stoichiometry: 1.0
species: 631518

631518
type: Species
is: http://identifiers.org/cas/51-41-2
is: C00547
has only substance units: false
is: CHEBI:18357
name: Noradrenaline_b
constant: false
boundary condition: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3828
in compartment: 623887
initial amount: NaN

848999
type: SpeciesReference
stoichiometry: 1.0
species: 631530

631530
type: Species
boundary condition: false
is: CHEBI:18357
constant: false
is: http://identifiers.org/pubchem.compound/3828
has only substance units: false
in compartment: 623911
is: C00547
is: http://identifiers.org/cas/51-41-2
initial concentration: 2.6E-4
initial amount: NaN
name: Noradrenaline_c

849059
type: SpeciesReference
stoichiometry: 1.0
species: 639918

849047
type: SpeciesReference
stoichiometry: 1.0
species: 629719

823260
type: Reaction
product: 823296
name: r2132
reactant: 823284
reversible: true
is: ENSMUSG00000032902
product: 823308
fast: false
notes: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: 823272

823296
type: SpeciesReference
stoichiometry: 1.0
species: 632143

823284
type: SpeciesReference
stoichiometry: 1.0
species: 632659

823308
type: SpeciesReference
stoichiometry: 1.0
species: 632671

823272
type: SpeciesReference
stoichiometry: 1.0
species: 632155

640554
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623863
name: cis-laur-5-enoyl-CoA_m

675624
type: Constraint
message: Warning: Species concentration Malonyl-Carnitin_m is out of the soft bounds.

668844
type: Constraint
message: Error: Species concentration gamma-Linolenoyl-CoA_r is out of the hard bounds.

812257
type: Reaction
fast: false
reactant: 812293
reactant: 812281
product: 812329
name: r1961
product: 812317
reversible: false
is: ENSMUSG00000031904
notes: Y+LAT2 Utilized transport
reactant: 812269
product: 812305

812293
type: SpeciesReference
stoichiometry: 1.0
species: 630067

812281
type: SpeciesReference
stoichiometry: 1.0
species: 633091

812329
type: SpeciesReference
stoichiometry: 1.0
species: 630079

812317
type: SpeciesReference
stoichiometry: 1.0
species: 633079

812269
type: SpeciesReference
stoichiometry: 1.0
species: 627571

812305
type: SpeciesReference
stoichiometry: 1.0
species: 627559

637015
type: Species
in compartment: 623851
is: P02671
is: C00393
is: http://identifiers.org/pubchem.compound/3683
initial concentration: 1.0E-10
has only substance units: false
name: Fibrinogen_l
boundary condition: false
is: http://identifiers.org/cas/9001-32-5
constant: false
initial amount: NaN

676343
type: Constraint
message: Warning: Species concentration Collagen_CO6A2_c is out of the soft bounds.

636271
type: Species
is: http://identifiers.org/pubchem.compound/8044
constant: false
has only substance units: false
in compartment: 623911
name: Hexanoyl-ACP_c
initial concentration: 2.6E-4
boundary condition: false
initial amount: NaN
is: C05749

681131
type: Reaction
is: R00205
reactant: 681167
name: r0055
product: 681191
notes: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
reversible: true
reactant: 681143
fast: false
product: 681179
reactant: 681155

681167
type: SpeciesReference
stoichiometry: 1.0
species: 624547

681191
type: SpeciesReference
stoichiometry: 1.0
species: 624499

681143
type: SpeciesReference
stoichiometry: 1.0
species: 631494

631494
type: Species
is: C00546
is: CHEBI:17158
name: Methylglyoxal_c
initial amount: NaN
initial concentration: 2.6E-4
boundary condition: false
in compartment: 623911
is: http://identifiers.org/cas/78-98-8
is: http://identifiers.org/pubchem.compound/3827
constant: false
has only substance units: false

681179
type: SpeciesReference
stoichiometry: 1.0
species: 625195

681155
type: SpeciesReference
stoichiometry: 1.0
species: 624259

725528
type: Reaction
reactant: 725552
product: 725564
name: r0771
reactant: 725540
is: R04967
notes: Tetradecanoyl-[acyl-carrier protein]:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) Fatty acid biosynthesis EC:2.3.1.85
fast: false
product: 725576
is: K10780
reversible: true
is: ENSMUSG00000025153
is: K00665

725552
type: SpeciesReference
stoichiometry: 1.0
species: 624547

725564
type: SpeciesReference
stoichiometry: 1.0
species: 624499

725540
type: SpeciesReference
stoichiometry: 1.0
species: 636415

636415
type: Species
constant: false
initial concentration: 2.6E-4
in compartment: 623911
has only substance units: false
boundary condition: false
is: C05761
is: http://identifiers.org/pubchem.compound/8056
name: Tetradecanoyl-ACP_c
initial amount: NaN

725576
type: SpeciesReference
stoichiometry: 1.0
species: 636403

847571
type: Reaction
product: 847595
reactant: 847583
notes: Zinc (Zn$^{2+}$)-Iron (Fe$^{2+}$) Permease (ZIP) TCDB:2.A.57.1.4
is: ENSMUSG00000024891
fast: false
reversible: true
name: r2463

847595
type: SpeciesReference
stoichiometry: 1.0
species: 632311

632311
type: Species
is: http://identifiers.org/cas/951-77-9
is: CHEBI:15698
is: C00881
in compartment: 623911
boundary condition: false
name: Deoxycytidine_c
initial concentration: 2.6E-4
initial amount: NaN
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/4137

847583
type: SpeciesReference
stoichiometry: 1.0
species: 632323

632323
type: Species
constant: false
boundary condition: true
is: CHEBI:15698
initial concentration: 2.6E-4
initial amount: NaN
name: Deoxycytidine_s
is: http://identifiers.org/pubchem.compound/4137
in compartment: 623935
has only substance units: false
is: C00881
is: http://identifiers.org/cas/951-77-9

658670
type: Constraint
message: Error: Species concentration Crotonyl-CoA_m is out of the hard bounds.

660397
type: Constraint
message: Error: Species concentration FADH2_m is out of the hard bounds.

848483
type: Reaction
notes: Major Facilitator(MFS) TCDB:2.A.18.6.8
product: 848543
name: r2479
fast: false
reactant: 848507
product: 848531
is: ENSMUSG00000031170
reactant: 848495
product: 848555
reversible: false
reactant: 848519

848543
type: SpeciesReference
stoichiometry: 1.0
species: 633079

848507
type: SpeciesReference
stoichiometry: 1.0
species: 633091

848531
type: SpeciesReference
stoichiometry: 1.0
species: 628147

848495
type: SpeciesReference
stoichiometry: 1.0
species: 628159

848555
type: SpeciesReference
stoichiometry: 1.0
species: 626635

848519
type: SpeciesReference
stoichiometry: 1.0
species: 626623

671232
type: Constraint
message: Warning: Species concentration PE-PS-VLDL-pool_c is out of the soft bounds.

735690
type: Reaction
product: 735714
reactant: 735702
notes: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
is: ENSMUSG00000030382
fast: false
reversible: true
name: r0984

735714
type: SpeciesReference
stoichiometry: 1.0
species: 633211

735702
type: SpeciesReference
stoichiometry: 1.0
species: 633235

633235
type: Species
is: http://identifiers.org/cas/57-11-4
initial concentration: 2.6E-4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4692
is: CHEBI:25629
has only substance units: false
boundary condition: false
in compartment: 623851
is: C01530
constant: false
name: Stearate_l

699220
type: Reaction
is: ENSMUSG00000028792
is: R01547
is: ENSMUSG00000028527
reactant: 699232
product: 699268
is: ENSMUSG00000039058
product: 699256
fast: false
is: ENSMUSG00000041323
reversible: true
is: ENSMUSG00000026817
notes: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
reactant: 699244
name: r0345
is: K00939

699232
type: SpeciesReference
stoichiometry: 1.0
species: 624331

699268
type: SpeciesReference
stoichiometry: 1.0
species: 628855

699256
type: SpeciesReference
stoichiometry: 1.0
species: 624655

699244
type: SpeciesReference
stoichiometry: 1.0
species: 630415

630415
type: Species
is: http://identifiers.org/pubchem.compound/3651
initial amount: NaN
is: C00360
is: CHEBI:17713
boundary condition: false
is: http://identifiers.org/cas/653-63-4
has only substance units: false
initial concentration: 2.6E-4
constant: false
name: dAMP_c
in compartment: 623911

638010
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1-Acylglycerol-3P-VLDL-TG1-pool_c

783941
type: Reaction
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: 783965
reversible: true
product: 783989
product: 783977
is: ENSMUSG00000040010
name: r1606
fast: false
reactant: 783953

783965
type: SpeciesReference
stoichiometry: 1.0
species: 629551

783989
type: SpeciesReference
stoichiometry: 1.0
species: 629563

783977
type: SpeciesReference
stoichiometry: 1.0
species: 626407

783953
type: SpeciesReference
stoichiometry: 1.0
species: 626419

781182
type: Reaction
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: ENSMUSG00000040010
reactant: 781206
reactant: 781194
fast: false
product: 781218
reversible: true
product: 781230
name: r1560

781206
type: SpeciesReference
stoichiometry: 1.0
species: 626407

781194
type: SpeciesReference
stoichiometry: 1.0
species: 625687

781218
type: SpeciesReference
stoichiometry: 1.0
species: 625675

781230
type: SpeciesReference
stoichiometry: 1.0
species: 626419

668916
type: Constraint
message: Error: Species concentration Arachidonyl-CoA_c is out of the hard bounds.

666768
type: Constraint
message: Warning: Species concentration Decanoyl-ACP_c is out of the soft bounds.

653690
type: Constraint
message: Warning: Species concentration Uridine_c is out of the soft bounds.

724700
type: Reaction
is: ENSMUSG00000010025
is: ENSMUSG00000026687
is: R04903
reactant: 724736
is: ENSMUSG00000053644
name: r0758
reactant: 724712
is: K00149
is: ENSMUSG00000053279
fast: false
reversible: true
notes: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
is: ENSMUSG00000035561
product: 724760
product: 724748
reactant: 724724
is: K14085
is: K00128

724736
type: SpeciesReference
stoichiometry: 1.0
species: 624259

724712
type: SpeciesReference
stoichiometry: 1.0
species: 636139

724760
type: SpeciesReference
stoichiometry: 1.0
species: 636151

724748
type: SpeciesReference
stoichiometry: 1.0
species: 624451

724724
type: SpeciesReference
stoichiometry: 1.0
species: 624403

649358
type: Constraint
message: Error: Species concentration Ferrocytochrome_C_m is out of the hard bounds.

892275
type: Reaction
reactant: 892455
is: ENSMUSG00000025082
product: 892599
reactant: 892515
reactant: 892491
reactant: 892347
reactant: 892431
reactant: 892407
product: 892575
reactant: 892539
product: 892551
reactant: 892335
reactant: 892371
reactant: 892419
reversible: false
reactant: 892503
reactant: 892311
fast: false
reactant: 892527
reactant: 892323
reactant: 892479
reactant: 892287
reactant: 892299
product: 892587
reactant: 892467
reactant: 892383
product: 892563
notes: AMACO Protein assembly
reactant: 892443
reactant: 892359
reactant: 892395
name: r2662

892455
type: SpeciesReference
stoichiometry: 58.0
species: 626155

892599
type: SpeciesReference
stoichiometry: 755.0
species: 624919

892515
type: SpeciesReference
stoichiometry: 13.0
species: 626695

892491
type: SpeciesReference
stoichiometry: 72.0
species: 628531

892347
type: SpeciesReference
stoichiometry: 66.0
species: 625627

892431
type: SpeciesReference
stoichiometry: 47.0
species: 628075

892407
type: SpeciesReference
stoichiometry: 12.0
species: 626407

892575
type: SpeciesReference
stoichiometry: 2265.0
species: 624727

892539
type: SpeciesReference
stoichiometry: 3020.0
species: 624259

892551
type: SpeciesReference
stoichiometry: 1.0
species: 641634

641634
type: Species
is: Q5GFL6
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_VWA2_c

892335
type: SpeciesReference
stoichiometry: 31.0
species: 626575

892371
type: SpeciesReference
stoichiometry: 18.0
species: 630798

892419
type: SpeciesReference
stoichiometry: 15.0
species: 628147

892503
type: SpeciesReference
stoichiometry: 7.0
species: 626539

892311
type: SpeciesReference
stoichiometry: 32.0
species: 625867

892527
type: SpeciesReference
stoichiometry: 3020.0
species: 624331

892323
type: SpeciesReference
stoichiometry: 44.0
species: 625291

892479
type: SpeciesReference
stoichiometry: 36.0
species: 628699

892287
type: SpeciesReference
stoichiometry: 66.0
species: 625675

892299
type: SpeciesReference
stoichiometry: 27.0
species: 627007

892587
type: SpeciesReference
stoichiometry: 755.0
species: 625135

892467
type: SpeciesReference
stoichiometry: 56.0
species: 626299

892383
type: SpeciesReference
stoichiometry: 25.0
species: 625819

892563
type: SpeciesReference
stoichiometry: 2265.0
species: 624655

892443
type: SpeciesReference
stoichiometry: 32.0
species: 626251

892359
type: SpeciesReference
stoichiometry: 17.0
species: 627835

892395
type: SpeciesReference
stoichiometry: 81.0
species: 627559

626455
type: Species
is: http://identifiers.org/pubchem.compound/3374
is: C00074
initial amount: NaN
initial concentration: 1.7E-5
constant: false
in compartment: 623911
name: PEP_c
boundary condition: false
has only substance units: false
is: http://identifiers.org/cas/138-08-9
is: CHEBI:18021

647798
type: Constraint
message: Error: Species concentration Sucrose_s is out of the hard bounds.

740550
type: Reaction
notes: Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.4
is: ENSMUSG00000027219
fast: false
product: 740598
name: r1089
product: 740586
reactant: 740574
reversible: false
reactant: 740562

740598
type: SpeciesReference
stoichiometry: 1.0
species: 630703

740586
type: SpeciesReference
stoichiometry: 1.0
species: 633079

740574
type: SpeciesReference
stoichiometry: 1.0
species: 630715

740562
type: SpeciesReference
stoichiometry: 1.0
species: 633091

808393
type: Reaction
product: 808441
product: 808453
reactant: 808405
reversible: false
product: 808465
fast: false
notes: Y+LAT2 Utilized transport
reactant: 808417
reactant: 808429
is: ENSMUSG00000031904
name: r1915

808441
type: SpeciesReference
stoichiometry: 1.0
species: 625627

808453
type: SpeciesReference
stoichiometry: 1.0
species: 633079

808405
type: SpeciesReference
stoichiometry: 1.0
species: 625639

808465
type: SpeciesReference
stoichiometry: 1.0
species: 627847

808417
type: SpeciesReference
stoichiometry: 1.0
species: 633091

808429
type: SpeciesReference
stoichiometry: 1.0
species: 627835

756323
type: Reaction
product: 756347
reactant: 756335
notes: Vesicular transport
fast: false
reversible: true
name: r1270

756347
type: SpeciesReference
stoichiometry: 1.0
species: 637603

637603
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: PS-VLDL-pool_c

756335
type: SpeciesReference
stoichiometry: 1.0
species: 637591

637591
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623887
name: PS-VLDL-pool_b

674484
type: Constraint
message: Error: Species concentration prostaglandin-d3_c is out of the hard bounds.

677075
type: Constraint
message: Error: Species concentration Collagen_EMID2_c is out of the hard bounds.

666241
type: Constraint
message: Warning: Species concentration 3-Methoxy-4-hydroxyphenylacetaldehyde_m is out of the soft bounds.

659269
type: Constraint
message: Error: Species concentration Squalene_2,3-oxide_r is out of the hard bounds.

730147
type: Reaction
product: 730171
reactant: 730159
notes: Transport reaction
fast: false
reversible: true
name: r0862

730171
type: SpeciesReference
stoichiometry: 1.0
species: 624787

730159
type: SpeciesReference
stoichiometry: 1.0
species: 624799

655238
type: Constraint
message: Error: Species concentration Urate_s is out of the hard bounds.

628267
type: Species
in compartment: 623911
is: http://identifiers.org/cas/6027-13-0
name: Homocysteine_c
boundary condition: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3455
constant: false
initial amount: NaN
is: C00155
has only substance units: false
is: CHEBI:17588

732055
type: Reaction
product: 732079
reactant: 732067
notes: Major Facilitator(MFS) TCDB:2.A.1.1.13
is: ENSMUSG00000028976
fast: false
reversible: true
name: r0901

732079
type: SpeciesReference
stoichiometry: 1.0
species: 627367

627367
type: Species
initial concentration: 2.6E-4
is: C00114
in compartment: 623911
has only substance units: false
boundary condition: true
is: CHEBI:15354
is: http://identifiers.org/cas/62-49-7
constant: false
initial amount: NaN
name: Choline_c
is: http://identifiers.org/pubchem.compound/3414

732067
type: SpeciesReference
stoichiometry: 1.0
species: 627379

627379
type: Species
constant: false
is: http://identifiers.org/cas/62-49-7
boundary condition: true
in compartment: 623935
is: CHEBI:15354
is: http://identifiers.org/pubchem.compound/3414
is: C00114
initial concentration: 2.6E-4
has only substance units: false
initial amount: NaN
name: Choline_s

658238
type: Constraint
message: Error: Species concentration Oleate_l is out of the hard bounds.

731983
type: Reaction
product: 732007
reactant: 731995
notes: Amino acid transporter ATB0+ Facilitated diffusion
is: ENSMUSG00000031089
fast: false
reversible: true
name: r0899

732007
type: SpeciesReference
stoichiometry: 1.0
species: 627067

731995
type: SpeciesReference
stoichiometry: 1.0
species: 627055

664801
type: Constraint
message: Warning: Species concentration (S)-Hydroxyhexanoyl-CoA_m is out of the soft bounds.

649766
type: Constraint
message: Error: Species concentration Histidine_s is out of the hard bounds.

788346
type: Reaction
fast: false
product: 788418
reversible: false
name: r1677
reactant: 788370
is: ENSMUSG00000031904
reactant: 788358
reactant: 788382
product: 788406
notes: Y+LAT2 Utilized transport
product: 788394

788418
type: SpeciesReference
stoichiometry: 1.0
species: 633079

788370
type: SpeciesReference
stoichiometry: 1.0
species: 626575

788358
type: SpeciesReference
stoichiometry: 1.0
species: 625639

788382
type: SpeciesReference
stoichiometry: 1.0
species: 633091

788406
type: SpeciesReference
stoichiometry: 1.0
species: 626587

788394
type: SpeciesReference
stoichiometry: 1.0
species: 625627

668892
type: Constraint
message: Error: Species concentration Arachidonyl-CoA_r is out of the hard bounds.

653222
type: Constraint
message: Error: Species concentration Dihydrobiopterin_c is out of the hard bounds.

659569
type: Constraint
message: Warning: Species concentration Sphinganine-1P_c is out of the soft bounds.

782622
type: Reaction
fast: false
reactant: 782634
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: 782658
reactant: 782646
product: 782670
is: ENSMUSG00000040010
reversible: true
name: r1584

782634
type: SpeciesReference
stoichiometry: 1.0
species: 626263

782658
type: SpeciesReference
stoichiometry: 1.0
species: 626251

782646
type: SpeciesReference
stoichiometry: 1.0
species: 630798

782670
type: SpeciesReference
stoichiometry: 1.0
species: 630810

669156
type: Constraint
message: Error: Species concentration PE-VLDL-pool_b is out of the hard bounds.

636031
type: Species
initial concentration: 2.6E-4
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/7865
in compartment: 623863
constant: false
is: C05520
is: CHEBI:28095
name: 2-Amino-3-oxoadipate_m
initial amount: NaN

661849
type: Constraint
message: Warning: Species concentration O-Acetylcarnitine_p is out of the soft bounds.

676547
type: Constraint
message: Error: Species concentration Collagen_CO9A3_c is out of the hard bounds.

642978
type: Constraint
message: Error: Species concentration NADH_p is out of the hard bounds.

674292
type: Constraint
message: Error: Species concentration prostaglandin-c1_c is out of the hard bounds.

656558
type: Constraint
message: Error: Species concentration Bilirubin_c is out of the hard bounds.

840576
type: Reaction
product: 840600
reactant: 840588
notes: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
name: r2346

840600
type: SpeciesReference
stoichiometry: 1.0
species: 639522

840588
type: SpeciesReference
stoichiometry: 1.0
species: 639534

785578
type: Reaction
name: r1633
product: 785617
product: 785630
reversible: true
reactant: 785604
reactant: 785591
is: ENSMUSG00000040010
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

785617
type: SpeciesReference
stoichiometry: 1.0
species: 626695

785630
type: SpeciesReference
stoichiometry: 1.0
species: 629563

785604
type: SpeciesReference
stoichiometry: 1.0
species: 629551

785591
type: SpeciesReference
stoichiometry: 1.0
species: 626707

735762
type: Reaction
product: 735786
reactant: 735774
notes: Vesicular transport
fast: false
reversible: false
name: r0986

735786
type: SpeciesReference
stoichiometry: 1.0
species: 633247

735774
type: SpeciesReference
stoichiometry: 1.0
species: 633283

717472
type: Reaction
is: ENSMUSG00000053644
reactant: 717508
is: K14085
is: ENSMUSG00000026687
reactant: 717496
fast: false
reactant: 717484
is: K00149
reversible: true
is: ENSMUSG00000010025
product: 717532
is: K00128
notes: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
is: R03869
name: r0642
product: 717520
is: ENSMUSG00000035561
is: ENSMUSG00000053279

717508
type: SpeciesReference
stoichiometry: 1.0
species: 624259

717496
type: SpeciesReference
stoichiometry: 1.0
species: 624403

717484
type: SpeciesReference
stoichiometry: 1.0
species: 630319

630319
type: Species
is: CHEBI:16256
constant: false
has only substance units: false
name: 2-Methyl-3-oxopropanoate_c
initial amount: NaN
in compartment: 623911
boundary condition: false
is: C00349
is: http://identifiers.org/pubchem.compound/3642
initial concentration: 2.6E-4

717532
type: SpeciesReference
stoichiometry: 1.0
species: 624451

717520
type: SpeciesReference
stoichiometry: 1.0
species: 633631

633631
type: Species
is: C02170
boundary condition: false
initial concentration: 2.6E-4
is: CHEBI:30860
constant: false
is: http://identifiers.org/cas/516-05-2
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5245
has only substance units: false
name: Methylmalonate_c
in compartment: 623911

819780
type: Reaction
reversible: false
product: 819828
is: ENSMUSG00000017765
fast: false
reactant: 819804
name: r2074
notes: Cation-Chloride Cotransporter (CCC) TCDB:2.A.30.5.1
reactant: 819792
product: 819816

819828
type: SpeciesReference
stoichiometry: 1.0
species: 627403

627403
type: Species
boundary condition: false
in compartment: 623935
is: http://identifiers.org/pubchem.compound/3415
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:17996
is: http://identifiers.org/cas/7782-50-5
name: Chloride_s
initial concentration: 2.6E-4
is: C00115

819804
type: SpeciesReference
stoichiometry: 1.0
species: 627391

627391
type: Species
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3415
constant: false
is: http://identifiers.org/cas/7782-50-5
is: CHEBI:17996
boundary condition: false
in compartment: 623911
name: Chloride_c
initial amount: NaN
is: C00115
has only substance units: false

819792
type: SpeciesReference
stoichiometry: 1.0
species: 629215

819816
type: SpeciesReference
stoichiometry: 1.0
species: 629227

673980
type: Constraint
message: Error: Species concentration S-glutathionyl-2-4-dinitrobenzene_c is out of the hard bounds.

684089
type: Reaction
product: 684137
notes: ATP:(d)GMP phosphotransferase Purine metabolism EC:2.7.4.8
is: ENSMUSG00000020444
fast: false
reactant: 684113
product: 684125
reactant: 684101
reversible: true
is: R00332
is: K00942
name: r0101

684137
type: SpeciesReference
stoichiometry: 1.0
species: 625567

684113
type: SpeciesReference
stoichiometry: 1.0
species: 628015

628015
type: Species
is: CHEBI:17345
has only substance units: false
is: http://identifiers.org/pubchem.compound/3444
boundary condition: false
name: GMP_c
constant: false
is: http://identifiers.org/cas/85-32-5
initial amount: NaN
in compartment: 623911
is: C00144
initial concentration: 2.6E-4

684125
type: SpeciesReference
stoichiometry: 1.0
species: 624655

684101
type: SpeciesReference
stoichiometry: 1.0
species: 624331

698500
type: Reaction
product: 698548
reactant: 698512
reactant: 698524
is: R01456
is: K00213
fast: false
notes: Cholesterol:NADP+ delta7-oxidoreductase Biosynthesis of steroids EC:1.3.1.21
product: 698536
is: ENSMUSG00000058454
name: r0333
reversible: true

698548
type: SpeciesReference
stoichiometry: 1.0
species: 624487

624487
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/3307
constant: false
has only substance units: false
name: NADPH_r
is: C00005
initial amount: NaN
is: CHEBI:16474
is: http://identifiers.org/cas/2646-71-1
initial concentration: 5.1E-5
in compartment: 623923

698512
type: SpeciesReference
stoichiometry: 1.0
species: 628639

698524
type: SpeciesReference
stoichiometry: 1.0
species: 624535

698536
type: SpeciesReference
stoichiometry: 1.0
species: 632851

813937
type: Reaction
is: ENSMUSG00000031904
reactant: 813949
reversible: false
product: 813997
reactant: 813973
reactant: 813961
notes: Y+LAT2 Utilized transport
fast: false
product: 814009
product: 813985
name: r1981

813949
type: SpeciesReference
stoichiometry: 1.0
species: 628711

813997
type: SpeciesReference
stoichiometry: 1.0
species: 633079

813973
type: SpeciesReference
stoichiometry: 1.0
species: 630067

813961
type: SpeciesReference
stoichiometry: 1.0
species: 633091

814009
type: SpeciesReference
stoichiometry: 1.0
species: 630079

813985
type: SpeciesReference
stoichiometry: 1.0
species: 628699

645329
type: Constraint
message: Error: Species concentration Glycine_l is out of the hard bounds.

673572
type: Constraint
message: Error: Species concentration taurolithocholate_s is out of the hard bounds.

638922
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623923
name: NADH-redox-potential_r

660721
type: Constraint
message: Warning: Species concentration Cysteamine_c is out of the soft bounds.

642210
type: Constraint
message: Error: Species concentration ApoA1_l is out of the hard bounds.

660805
type: Constraint
message: Error: Species concentration Lanosterol_r is out of the hard bounds.

656306
type: Constraint
message: Warning: Species concentration dTTP_c is out of the soft bounds.

628579
type: Species
has only substance units: false
in compartment: 623935
is: C00184
initial concentration: 2.6E-4
boundary condition: true
initial amount: NaN
is: CHEBI:16016
name: Glycerone_s
is: http://identifiers.org/pubchem.compound/3484
is: http://identifiers.org/cas/96-26-4
constant: false

679127
type: Reaction
reactant: 679151
reversible: true
is: ENSMUSG00000031584
name: r0022
product: 679163
fast: false
is: R00094
is: K00383
product: 679175
reactant: 679139
notes: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7

679151
type: SpeciesReference
stoichiometry: 2.0
species: 625939

625939
type: Species
is: C00051
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3353
is: CHEBI:16856
boundary condition: false
initial amount: NaN
name: GSH_m
initial concentration: 2.6E-4
in compartment: 623863
is: http://identifiers.org/cas/70-18-8

679163
type: SpeciesReference
stoichiometry: 1.0
species: 627679

627679
type: Species
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3427
is: C00127
is: http://identifiers.org/cas/27025-41-8
constant: false
in compartment: 623863
is: CHEBI:17858
has only substance units: false
boundary condition: false
initial amount: NaN
name: GSSG_m

679175
type: SpeciesReference
stoichiometry: 1.0
species: 624463

679139
type: SpeciesReference
stoichiometry: 1.0
species: 624415

676847
type: Constraint
message: Warning: Species concentration Collagen_COKA1_c is out of the soft bounds.

634327
type: Species
is: C03594
is: http://identifiers.org/pubchem.compound/6385
in compartment: 623923
initial amount: NaN
boundary condition: false
is: CHEBI:17500
initial concentration: 2.6E-4
constant: false
name: 7alpha-Hydroxycholesterol_r
has only substance units: false

647017
type: Constraint
message: Error: Species concentration UTP_c is out of the hard bounds.

670812
type: Constraint
message: Error: Species concentration Fatty-acid-VLDL-TG1-pool_c is out of the hard bounds.

635755
type: Species
is: http://identifiers.org/pubchem.compound/7808
in compartment: 623863
boundary condition: false
initial amount: NaN
is: CHEBI:17278
is: http://identifiers.org/cas/862-53-3
has only substance units: false
is: C05446
name: 5beta-Cholestane-3alpha,7alpha,12alpha,26-tetrol_m
initial concentration: 2.6E-4
constant: false

727100
type: Reaction
is: K00659
fast: false
product: 727136
product: 727148
reactant: 727112
name: r0799
reversible: false
is: ENSMUSG00000039653
is: R08745
reactant: 727124
notes: glycine N-choloyltransferase EC:2.3.1.65

727136
type: SpeciesReference
stoichiometry: 1.0
species: 624823

727148
type: SpeciesReference
stoichiometry: 1.0
species: 635947

727112
type: SpeciesReference
stoichiometry: 1.0
species: 635563

635563
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/7715
initial amount: NaN
initial concentration: 2.6E-4
name: Chenodeoxycholoyl-CoA_p
is: CHEBI:28701
is: C05337
has only substance units: false
constant: false
in compartment: 623899

727124
type: SpeciesReference
stoichiometry: 1.0
species: 629311

629311
type: Species
is: http://identifiers.org/pubchem.compound/3544
initial amount: NaN
has only substance units: false
initial concentration: 2.6E-4
boundary condition: false
is: C00245
is: http://identifiers.org/cas/107-35-7
in compartment: 623899
constant: false
is: CHEBI:15891
name: Taurine_p

851914
type: Reaction
product: 851938
reactant: 851926
notes: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: ENSMUSG00000027075
fast: false
reversible: true
name: r2527

851938
type: SpeciesReference
stoichiometry: 1.0
species: 626539

851926
type: SpeciesReference
stoichiometry: 1.0
species: 626551

634291
type: Species
in compartment: 623863
is: C03465
boundary condition: false
is: http://identifiers.org/pubchem.compound/6284
has only substance units: false
initial amount: NaN
is: CHEBI:28654
initial concentration: 2.6E-4
constant: false
name: 2-Oxo-3-methylvalerate_m

656966
type: Constraint
message: Error: Species concentration Pyridoxamine_c is out of the hard bounds.

706590
type: Reaction
reversible: true
is: R01986
reactant: 706614
name: r0464
reactant: 706602
is: K00128
is: K00149
product: 706638
product: 706650
reactant: 706626
notes: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
is: K14085
is: ENSMUSG00000029455
fast: false

706614
type: SpeciesReference
stoichiometry: 1.0
species: 631566

631566
type: Species
name: 4-Aminobutanal_m
boundary condition: false
is: C00555
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3835
initial amount: NaN
is: CHEBI:17769
initial concentration: 2.6E-4
in compartment: 623863

706602
type: SpeciesReference
stoichiometry: 1.0
species: 624295

706638
type: SpeciesReference
stoichiometry: 1.0
species: 630223

630223
type: Species
is: C00334
boundary condition: false
is: CHEBI:16865
in compartment: 623863
initial concentration: 2.6E-4
has only substance units: false
name: 4-Aminobutyrate_m
is: http://identifiers.org/pubchem.compound/3628
initial amount: NaN
constant: false
is: http://identifiers.org/cas/56-12-2

706650
type: SpeciesReference
stoichiometry: 1.0
species: 624511

706626
type: SpeciesReference
stoichiometry: 1.0
species: 624559

824028
type: Reaction
reactant: 824064
is: ENSMUSG00000030237
is: ENSMUSG00000063975
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: 824087
reactant: 824052
reactant: 824040
fast: false
product: 824076
reversible: true
is: ENSMUSG00000041698
is: ENSMUSG00000079262
product: 824099
name: r2144

824064
type: SpeciesReference
stoichiometry: 1.0
species: 625915

824087
type: SpeciesReference
stoichiometry: 1.0
species: 629731

824052
type: SpeciesReference
stoichiometry: 1.0
species: 629719

824040
type: SpeciesReference
stoichiometry: 1.0
species: 639750

824076
type: SpeciesReference
stoichiometry: 1.0
species: 639738

824099
type: SpeciesReference
stoichiometry: 1.0
species: 625927

720532
type: Reaction
is: ENSMUSG00000030382
reactant: 720544
reactant: 720568
notes: 3alpha,7alpha-Dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is: R04507
name: r0690
is: K08748
product: 720592
product: 720604
product: 720580
reversible: true
fast: false
reactant: 720556

720544
type: SpeciesReference
stoichiometry: 1.0
species: 624379

720568
type: SpeciesReference
stoichiometry: 1.0
species: 634747

634747
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate_p
is: C04554
initial concentration: 2.6E-4
boundary condition: false
constant: false
in compartment: 623899
has only substance units: false
is: CHEBI:16577
is: http://identifiers.org/pubchem.compound/7159
initial amount: NaN

720592
type: SpeciesReference
stoichiometry: 1.0
species: 624967

624967
type: Species
initial concentration: 1.0E-8
in compartment: 623899
initial amount: NaN
is: CHEBI:18361
is: C00013
constant: false
is: http://identifiers.org/cas/2466-09-3
name: PPi_p
boundary condition: false
is: http://identifiers.org/pubchem.compound/3315
has only substance units: false

720604
type: SpeciesReference
stoichiometry: 1.0
species: 634855

634855
type: Species
initial amount: NaN
initial concentration: 2.6E-4
in compartment: 623899
is: http://identifiers.org/pubchem.compound/7233
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA_p
is: CHEBI:15494
is: C04644
constant: false
boundary condition: false

720580
type: SpeciesReference
stoichiometry: 1.0
species: 625171

625171
type: Species
has only substance units: false
constant: false
is: http://identifiers.org/cas/61-19-8
boundary condition: false
is: CHEBI:16027
name: AMP_p
is: C00020
initial amount: NaN
initial concentration: 4.2E-4
in compartment: 623899
is: http://identifiers.org/pubchem.compound/3322

720556
type: SpeciesReference
stoichiometry: 1.0
species: 624823

668100
type: Constraint
message: Error: Species concentration Fibrinogen_l is out of the hard bounds.

647220
type: Constraint
message: Error: Species concentration Phenylalanine_c is out of the hard bounds.

655130
type: Constraint
message: Warning: Species concentration dTMP_s is out of the soft bounds.

638490
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1-Acylglycerol-VLDL-PE-pool_c

693257
type: Reaction
is: R01049
reactant: 693269
fast: false
is: K00948
notes: ATP:D-ribose-5-phosphate pyrophosphotransferase Pentose phosphate pathway / Purine metabolism EC:2.7.6.1
is: ENSMUSG00000025742
product: 693293
reactant: 693281
is: ENSMUSG00000031432
reversible: false
name: r0247
product: 693305

693269
type: SpeciesReference
stoichiometry: 1.0
species: 624331

693293
type: SpeciesReference
stoichiometry: 1.0
species: 625135

693281
type: SpeciesReference
stoichiometry: 1.0
species: 627463

693305
type: SpeciesReference
stoichiometry: 1.0
species: 627487

668760
type: Constraint
message: Warning: Species concentration Linoleoyl-CoA_r is out of the soft bounds.

652994
type: Constraint
message: Warning: Species concentration Nicotinate_c is out of the soft bounds.

672672
type: Constraint
message: Warning: Species concentration O-Butanoylcarnitine_m is out of the soft bounds.

655742
type: Constraint
message: Error: Species concentration Isoleucine_m is out of the hard bounds.

645077
type: Constraint
message: Warning: Species concentration Heme_m is out of the soft bounds.

833245
type: Reaction
product: 833317
reactant: 833257
reactant: 833269
is: ENSMUSG00000030236
reactant: 833281
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: 833293
name: r2253
fast: false
reversible: true
product: 833305

833317
type: SpeciesReference
stoichiometry: 1.0
species: 640002

833257
type: SpeciesReference
stoichiometry: 1.0
species: 639654

639654
type: Species
has only substance units: false
in compartment: 623935
initial concentration: 2.6E-4
is: C06462
boundary condition: false
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/8694
is: CHEBI:27491
name: leukotriene-f4_s

833269
type: SpeciesReference
stoichiometry: 1.0
species: 629719

833281
type: SpeciesReference
stoichiometry: 1.0
species: 639990

833293
type: SpeciesReference
stoichiometry: 1.0
species: 639642

639642
type: Species
has only substance units: false
is: C06462
boundary condition: false
initial amount: NaN
in compartment: 623911
is: http://identifiers.org/pubchem.compound/8694
constant: false
initial concentration: 2.6E-4
name: leukotriene-f4_c
is: CHEBI:27491

833305
type: SpeciesReference
stoichiometry: 1.0
species: 629731

674820
type: Constraint
message: Error: Species concentration prostaglandin-g2_c is out of the hard bounds.

642990
type: Constraint
message: Warning: Species concentration NADH_p is out of the soft bounds.

643506
type: Constraint
message: Error: Species concentration Pi_s is out of the hard bounds.

744331
type: Reaction
name: r1103
reactant: 744617
reactant: 744344
reactant: 744474
reactant: 744552
reactant: 744435
is: ENSMUSG00000059481
reactant: 744604
reversible: false
notes: Plasminogen Protein assembly
product: 744669
reactant: 744539
reactant: 744396
product: 744643
reactant: 744591
reactant: 744448
reactant: 744370
reactant: 744422
reactant: 744383
product: 744682
reactant: 744487
reactant: 744578
reactant: 744357
reactant: 744500
reactant: 744461
fast: false
reactant: 744513
product: 744656
product: 744630
reactant: 744565
reactant: 744526
reactant: 744409

744617
type: SpeciesReference
stoichiometry: 49.0
species: 625819

744344
type: SpeciesReference
stoichiometry: 37.0
species: 625675

744474
type: SpeciesReference
stoichiometry: 56.0
species: 626299

744552
type: SpeciesReference
stoichiometry: 56.0
species: 625291

744435
type: SpeciesReference
stoichiometry: 11.0
species: 626407

744604
type: SpeciesReference
stoichiometry: 36.0
species: 625867

744669
type: SpeciesReference
stoichiometry: 2430.0
species: 624655

744539
type: SpeciesReference
stoichiometry: 31.0
species: 626251

744396
type: SpeciesReference
stoichiometry: 24.0
species: 627835

744643
type: SpeciesReference
stoichiometry: 810.0
species: 625135

744591
type: SpeciesReference
stoichiometry: 40.0
species: 628147

744448
type: SpeciesReference
stoichiometry: 21.0
species: 626575

744370
type: SpeciesReference
stoichiometry: 48.0
species: 627007

744422
type: SpeciesReference
stoichiometry: 48.0
species: 627559

744383
type: SpeciesReference
stoichiometry: 62.0
species: 625627

744682
type: SpeciesReference
stoichiometry: 2430.0
species: 624727

744487
type: SpeciesReference
stoichiometry: 61.0
species: 628699

744578
type: SpeciesReference
stoichiometry: 3240.0
species: 624259

744357
type: SpeciesReference
stoichiometry: 42.0
species: 626155

744500
type: SpeciesReference
stoichiometry: 19.0
species: 626539

744461
type: SpeciesReference
stoichiometry: 69.0
species: 628075

744513
type: SpeciesReference
stoichiometry: 30.0
species: 626695

744656
type: SpeciesReference
stoichiometry: 810.0
species: 624919

744630
type: SpeciesReference
stoichiometry: 1.0
species: 637099

744565
type: SpeciesReference
stoichiometry: 3240.0
species: 624331

744526
type: SpeciesReference
stoichiometry: 48.0
species: 628531

744409
type: SpeciesReference
stoichiometry: 22.0
species: 630798

626719
type: Species
is: http://identifiers.org/pubchem.compound/3382
initial concentration: 2.6E-4
constant: false
has only substance units: false
is: http://identifiers.org/cas/60-18-4
initial amount: NaN
boundary condition: false
is: C00082
is: CHEBI:17895
name: Tyrosine_l
in compartment: 623851

645929
type: Constraint
message: Error: Species concentration UDP-galactose_r is out of the hard bounds.

781362
type: Reaction
reactant: 781374
name: r1563
reactant: 781386
fast: false
product: 781410
reversible: true
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: ENSMUSG00000040010
product: 781398

781374
type: SpeciesReference
stoichiometry: 1.0
species: 625687

781386
type: SpeciesReference
stoichiometry: 1.0
species: 626695

781410
type: SpeciesReference
stoichiometry: 1.0
species: 626707

781398
type: SpeciesReference
stoichiometry: 1.0
species: 625675

784421
type: Reaction
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: ENSMUSG00000040010
product: 784457
reversible: true
name: r1614
product: 784469
reactant: 784433
fast: false
reactant: 784445

784457
type: SpeciesReference
stoichiometry: 1.0
species: 626539

784469
type: SpeciesReference
stoichiometry: 1.0
species: 628543

784433
type: SpeciesReference
stoichiometry: 1.0
species: 626551

784445
type: SpeciesReference
stoichiometry: 1.0
species: 628531

624115
type: Species
is: P04114
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: ApoB100_c

671304
type: Constraint
message: Warning: Species concentration Acyl-CoA-Bile-PC-pool_c is out of the soft bounds.

718468
type: Reaction
is: ENSMUSG00000024132
product: 718492
fast: false
is: ENSMUSG00000022853
reversible: true
is: ENSMUSG00000021417
notes: 3-cis-Dodecenoyl-CoA delta3-cis-delta2-trans-isomerase EC:5.3.3.8
name: r0657
reactant: 718480
is: R04100

718492
type: SpeciesReference
stoichiometry: 1.0
species: 634099

634099
type: Species
boundary condition: false
is: CHEBI:15471
initial concentration: 1.0E-5
initial amount: NaN
in compartment: 623863
constant: false
is: C03221
is: http://identifiers.org/pubchem.compound/6094
name: (2E)-Dodecenoyl-CoA_m
has only substance units: false

718480
type: SpeciesReference
stoichiometry: 1.0
species: 634003

634003
type: Species
boundary condition: false
constant: false
is: C02944
is: http://identifiers.org/pubchem.compound/5863
has only substance units: false
initial amount: NaN
is: CHEBI:27989
initial concentration: 1.0E-5
in compartment: 623863
name: (3Z)-Dodecenoyl-CoA_m

757366
type: Reaction
name: r1287
is: ENSMUSG00000021759
product: 757402
is: K01080
fast: false
reactant: 757390
reactant: 757378
is: ENSMUSG00000028517
reversible: false
is: R02239
product: 757414
notes: 1,2-Diacyl-sn-glycerol 3-phosphate phosphohydrolase Glycerolipid metabolism / Glycerophospholipid metabolism EC:3.1.3.4
is: ENSMUSG00000052151

757402
type: SpeciesReference
stoichiometry: 1.0
species: 624727

757390
type: SpeciesReference
stoichiometry: 1.0
species: 624259

757378
type: SpeciesReference
stoichiometry: 1.0
species: 638646

757414
type: SpeciesReference
stoichiometry: 1.0
species: 638634

700876
type: Reaction
is: K00795
is: K00787
is: ENSMUSG00000059743
is: ENSMUSG00000021302
reactant: 700888
is: K13787
is: R01658
reactant: 700900
product: 700912
product: 700924
notes: Dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase Biosynthesis of steroids / Terpenoid biosynthesis EC:2.5.1.1
fast: false
reversible: true
name: r0373
is: K14066
is: K00804
is: K13789

700888
type: SpeciesReference
stoichiometry: 1.0
species: 629191

629191
type: Species
is: CHEBI:16057
is: http://identifiers.org/cas/358-72-5
initial concentration: 2.6E-4
has only substance units: false
in compartment: 623899
name: Dimethylallyl-PP_p
constant: false
is: C00235
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3534
boundary condition: false

700900
type: SpeciesReference
stoichiometry: 1.0
species: 627715

700912
type: SpeciesReference
stoichiometry: 1.0
species: 624967

700924
type: SpeciesReference
stoichiometry: 1.0
species: 630247

630247
type: Species
initial concentration: 2.6E-4
boundary condition: false
is: C00341
in compartment: 623899
initial amount: NaN
is: CHEBI:17211
is: http://identifiers.org/pubchem.compound/3634
name: Geranyl-PP_p
has only substance units: false
constant: false

701056
type: Reaction
product: 701092
fast: false
is: K00945
is: K13809
is: ENSMUSG00000028719
notes: ATP:CMP phosphotransferase Pyrimidine metabolism EC:2.7.4.14
product: 701104
is: R01665
reversible: true
reactant: 701068
is: K13800
is: K13799
reactant: 701080
name: r0376

701092
type: SpeciesReference
stoichiometry: 1.0
species: 624655

701104
type: SpeciesReference
stoichiometry: 1.0
species: 632035

632035
type: Species
boundary condition: false
is: C00705
in compartment: 623911
is: CHEBI:28846
initial concentration: 2.6E-4
has only substance units: false
is: http://identifiers.org/pubchem.compound/3972
name: dCDP_c
constant: false
initial amount: NaN

701068
type: SpeciesReference
stoichiometry: 1.0
species: 624331

701080
type: SpeciesReference
stoichiometry: 1.0
species: 629239

629239
type: Species
is: C00239
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3538
initial concentration: 2.6E-4
name: dCMP_c
boundary condition: false
constant: false
is: http://identifiers.org/cas/1032-65-1
has only substance units: false
in compartment: 623911
is: CHEBI:15918

667272
type: Constraint
message: Warning: Species concentration LTD4_c is out of the soft bounds.

666888
type: Constraint
message: Warning: Species concentration (2E)-Tetradecenoyl-ACP_c is out of the soft bounds.

669912
type: Constraint
message: Warning: Species concentration Cholesterol-ester-arach_r is out of the soft bounds.

655910
type: Constraint
message: Error: Species concentration (R)-Mevalonate_c is out of the hard bounds.

658058
type: Constraint
message: Warning: Species concentration Cholate_c is out of the soft bounds.

877745
type: Reaction
reactant: 877949
reactant: 877793
reactant: 877841
product: 878057
reactant: 877781
product: 878045
reactant: 877937
notes: collagen, type XIX, alpha 1 Protein assembly
reactant: 877985
reactant: 877769
product: 878021
reactant: 877925
reactant: 877997
fast: false
product: 878069
reactant: 877817
reactant: 877901
reactant: 877973
reactant: 877757
is: ENSMUSG00000026141
reactant: 877913
reactant: 877889
reactant: 877829
reactant: 877877
reactant: 877961
reactant: 878009
product: 878033
reactant: 877805
reactant: 877853
name: r2618
reversible: false
reactant: 877865

877949
type: SpeciesReference
stoichiometry: 30.0
species: 628699

877793
type: SpeciesReference
stoichiometry: 67.0
species: 625291

877841
type: SpeciesReference
stoichiometry: 57.0
species: 630798

878057
type: SpeciesReference
stoichiometry: 1142.0
species: 625135

877781
type: SpeciesReference
stoichiometry: 49.0
species: 625867

878045
type: SpeciesReference
stoichiometry: 3426.0
species: 624727

877937
type: SpeciesReference
stoichiometry: 53.0
species: 626299

877985
type: SpeciesReference
stoichiometry: 16.0
species: 626695

877769
type: SpeciesReference
stoichiometry: 14.0
species: 627007

878021
type: SpeciesReference
stoichiometry: 1.0
species: 641370

641370
type: Species
is: Q14993
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_COJA1_c

877925
type: SpeciesReference
stoichiometry: 47.0
species: 626155

877997
type: SpeciesReference
stoichiometry: 4568.0
species: 624331

878069
type: SpeciesReference
stoichiometry: 1142.0
species: 624919

877817
type: SpeciesReference
stoichiometry: 261.0
species: 625627

877901
type: SpeciesReference
stoichiometry: 173.0
species: 628075

877973
type: SpeciesReference
stoichiometry: 7.0
species: 626539

877757
type: SpeciesReference
stoichiometry: 52.0
species: 625675

877913
type: SpeciesReference
stoichiometry: 46.0
species: 626251

877889
type: SpeciesReference
stoichiometry: 30.0
species: 628147

877829
type: SpeciesReference
stoichiometry: 16.0
species: 627835

877877
type: SpeciesReference
stoichiometry: 18.0
species: 626407

877961
type: SpeciesReference
stoichiometry: 33.0
species: 628531

878009
type: SpeciesReference
stoichiometry: 4568.0
species: 624259

878033
type: SpeciesReference
stoichiometry: 3426.0
species: 624655

877805
type: SpeciesReference
stoichiometry: 25.0
species: 626575

877853
type: SpeciesReference
stoichiometry: 77.0
species: 625819

877865
type: SpeciesReference
stoichiometry: 71.0
species: 627559

656678
type: Constraint
message: Error: Species concentration Folate_s is out of the hard bounds.

652190
type: Constraint
message: Error: Species concentration Arachidonate_s is out of the hard bounds.

675756
type: Constraint
message: Error: Species concentration trans,cis-hexadeca-2,9-dienoyl-CoA_m is out of the hard bounds.

891627
type: Reaction
reactant: 891867
is: ENSMUSG00000070436
reactant: 891891
reactant: 891819
reactant: 891699
reactant: 891855
product: 891927
product: 891903
reactant: 891831
reactant: 891783
reactant: 891687
reactant: 891843
notes: AsTP3 Protein assembly
reactant: 891747
reactant: 891771
fast: false
reactant: 891735
reactant: 891651
product: 891915
reactant: 891723
reversible: false
reactant: 891795
name: r2660
reactant: 891759
reactant: 891711
reactant: 891807
reactant: 891675
reactant: 891879
product: 891939
product: 891951
reactant: 891639
reactant: 891663

891867
type: SpeciesReference
stoichiometry: 10.0
species: 626695

891891
type: SpeciesReference
stoichiometry: 1672.0
species: 624259

891819
type: SpeciesReference
stoichiometry: 33.0
species: 626299

891699
type: SpeciesReference
stoichiometry: 24.0
species: 625627

891855
type: SpeciesReference
stoichiometry: 4.0
species: 626539

891927
type: SpeciesReference
stoichiometry: 1254.0
species: 624727

891903
type: SpeciesReference
stoichiometry: 1.0
species: 641622

641622
type: Species
is: P50454
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_SERPH_c

891831
type: SpeciesReference
stoichiometry: 19.0
species: 628699

891783
type: SpeciesReference
stoichiometry: 15.0
species: 628075

891687
type: SpeciesReference
stoichiometry: 16.0
species: 626575

891843
type: SpeciesReference
stoichiometry: 28.0
species: 628531

891747
type: SpeciesReference
stoichiometry: 54.0
species: 627559

891771
type: SpeciesReference
stoichiometry: 11.0
species: 628147

891735
type: SpeciesReference
stoichiometry: 34.0
species: 625819

891651
type: SpeciesReference
stoichiometry: 2.0
species: 627007

891915
type: SpeciesReference
stoichiometry: 1254.0
species: 624655

891723
type: SpeciesReference
stoichiometry: 12.0
species: 630798

891795
type: SpeciesReference
stoichiometry: 13.0
species: 626251

891759
type: SpeciesReference
stoichiometry: 14.0
species: 626407

891711
type: SpeciesReference
stoichiometry: 14.0
species: 627835

891807
type: SpeciesReference
stoichiometry: 21.0
species: 626155

891675
type: SpeciesReference
stoichiometry: 27.0
species: 625291

891879
type: SpeciesReference
stoichiometry: 1672.0
species: 624331

891939
type: SpeciesReference
stoichiometry: 418.0
species: 625135

891951
type: SpeciesReference
stoichiometry: 418.0
species: 624919

891639
type: SpeciesReference
stoichiometry: 43.0
species: 625675

891663
type: SpeciesReference
stoichiometry: 24.0
species: 625867

646965
type: Constraint
message: Error: Species concentration PEP_c is out of the hard bounds.

628447
type: Species
boundary condition: false
initial concentration: 2.6E-4
is: C00169
constant: false
in compartment: 623911
initial amount: NaN
name: Carbamoyl-P_c
is: http://identifiers.org/pubchem.compound/3469
has only substance units: false
is: CHEBI:17672

769856
type: Reaction
product: 769880
reactant: 769868
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r1386

769880
type: SpeciesReference
stoichiometry: 1.0
species: 625819

769868
type: SpeciesReference
stoichiometry: 1.0
species: 633655

633655
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Protein_lysine_c

796660
type: Reaction
fast: false
product: 796720
reversible: false
product: 796708
notes: Y+LAT2 Utilized transport
reactant: 796684
reactant: 796696
name: r1776
product: 796732
is: ENSMUSG00000031904
reactant: 796672

796720
type: SpeciesReference
stoichiometry: 1.0
species: 630810

796708
type: SpeciesReference
stoichiometry: 1.0
species: 626575

796684
type: SpeciesReference
stoichiometry: 1.0
species: 630798

796696
type: SpeciesReference
stoichiometry: 1.0
species: 633091

796732
type: SpeciesReference
stoichiometry: 1.0
species: 633079

796672
type: SpeciesReference
stoichiometry: 1.0
species: 626587

626287
type: Species
is: http://identifiers.org/cas/56-85-9
is: C00064
initial amount: NaN
constant: false
in compartment: 623863
is: CHEBI:18050
is: http://identifiers.org/pubchem.compound/3364
has only substance units: false
boundary condition: false
initial concentration: 2.6E-4
name: Glutamine_m

671700
type: Constraint
message: Error: Species concentration Dihomo-gamma-linolenate_s is out of the hard bounds.

661153
type: Constraint
message: Warning: Species concentration Glycocholate_s is out of the soft bounds.

753479
type: Reaction
notes: 1,2-Diacyl-sn-glycerol acylhydrolase Glycerolipid metabolism EC:3.1.1.3
name: r1229
is: K12298
is: R02687
is: K14074
is: K14452
reversible: false
is: K14073
product: 753527
product: 753515
is: K14076
reactant: 753491
reactant: 753503
is: K14075
is: K13534
is: ENSMUSG00000032207
is: K01046
fast: false

753527
type: SpeciesReference
stoichiometry: 1.0
species: 638442

638442
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Fatty-acid-VLDL-PI-pool_c

753515
type: SpeciesReference
stoichiometry: 1.0
species: 638514

638514
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1-Acylglycerol-VLDL-PI-pool_c

753491
type: SpeciesReference
stoichiometry: 1.0
species: 624259

753503
type: SpeciesReference
stoichiometry: 1.0
species: 638274

638274
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1,2-Diacylglycerol-VLDL-PI-pool_c

647978
type: Constraint
message: Warning: Species concentration Sulfite_c is out of the soft bounds.

662389
type: Constraint
message: Error: Species concentration CoproporphyrinogenIII_c is out of the hard bounds.

710141
type: Reaction
reversible: false
fast: false
reactant: 710153
is: ENSMUSG00000021871
is: ENSMUSG00000068417
is: K03783
notes: Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.1
reactant: 710165
is: R02295
name: r0520
product: 710177
product: 710189
is: K03784

710153
type: SpeciesReference
stoichiometry: 1.0
species: 636535

710165
type: SpeciesReference
stoichiometry: 1.0
species: 624727

710177
type: SpeciesReference
stoichiometry: 1.0
species: 629455

710189
type: SpeciesReference
stoichiometry: 1.0
species: 631734

631734
type: Species
name: Ribose-1P_c
is: CHEBI:35425
boundary condition: false
is: http://identifiers.org/pubchem.compound/3894
is: C00620
constant: false
in compartment: 623911
initial concentration: 2.6E-4
has only substance units: false
initial amount: NaN

659389
type: Constraint
message: Error: Species concentration (R)-3-Hydroxybutanoate_c is out of the hard bounds.

643062
type: Constraint
message: Warning: Species concentration NADPH_m is out of the soft bounds.

641802
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623911
name: CoA-activated_acetyl_group_c

718720
type: Reaction
is: R04170
name: r0661
is: K13767
reactant: 718732
product: 718744
is: K07511
is: K07515
fast: false
is: K01782
reversible: true
is: K07514
product: 718756
is: ENSMUSG00000022853
is: K01692
notes: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: K01825

718732
type: SpeciesReference
stoichiometry: 1.0
species: 635251

718744
type: SpeciesReference
stoichiometry: 1.0
species: 634111

634111
type: Species
name: (2E)-Dodecenoyl-CoA_p
has only substance units: false
initial amount: NaN
initial concentration: 1.0E-5
is: C03221
constant: false
in compartment: 623899
is: http://identifiers.org/pubchem.compound/6094
boundary condition: false
is: CHEBI:15471

718756
type: SpeciesReference
stoichiometry: 1.0
species: 624307

664921
type: Constraint
message: Warning: Species concentration (2E)-Hexadecenoyl-CoA_c is out of the soft bounds.

725924
type: Reaction
reactant: 725936
product: 725972
name: r0780
reversible: true
product: 725960
is: ENSMUSG00000024799
is: K00222
notes: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
reactant: 725948
fast: false
is: R05639

725936
type: SpeciesReference
stoichiometry: 1.0
species: 635047

725972
type: SpeciesReference
stoichiometry: 1.0
species: 624487

725960
type: SpeciesReference
stoichiometry: 1.0
species: 636919

636919
type: Species
is: C11455
initial amount: NaN
in compartment: 623923
initial concentration: 2.6E-4
is: CHEBI:17813
is: http://identifiers.org/pubchem.compound/13626
has only substance units: false
constant: false
boundary condition: false
name: 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol_r

725948
type: SpeciesReference
stoichiometry: 1.0
species: 624535

783461
type: Reaction
reactant: 783473
product: 783497
is: ENSMUSG00000040010
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
name: r1598
product: 783509
fast: false
reactant: 783485

783473
type: SpeciesReference
stoichiometry: 1.0
species: 626419

783497
type: SpeciesReference
stoichiometry: 1.0
species: 626407

783509
type: SpeciesReference
stoichiometry: 1.0
species: 626587

783485
type: SpeciesReference
stoichiometry: 1.0
species: 626575

720196
type: Reaction
reactant: 720232
reactant: 720208
is: R04445
is: K13821
reactant: 720220
name: r0686
product: 720256
is: ENSMUSG00000028737
notes: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is: K00294
fast: false
product: 720244
reversible: true

720232
type: SpeciesReference
stoichiometry: 1.0
species: 624559

720208
type: SpeciesReference
stoichiometry: 1.0
species: 634639

720220
type: SpeciesReference
stoichiometry: 2.0
species: 624295

720256
type: SpeciesReference
stoichiometry: 1.0
species: 636583

720244
type: SpeciesReference
stoichiometry: 1.0
species: 624511

670092
type: Constraint
message: Error: Species concentration 1-Acylglycerol-3P-VLDL-TG1-pool_c is out of the hard bounds.

712313
type: Reaction
reactant: 712325
notes: acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase Glycolysis / Gluconeogenesis / Alanine and aspartate metabolism / Pyruvate metabolism EC:2.3.1.12
reversible: true
reactant: 712337
product: 712361
product: 712349
name: r0555
is: R02569
fast: false
is: ENSMUSG00000000168
is: K00627

712325
type: SpeciesReference
stoichiometry: 1.0
species: 625267

712337
type: SpeciesReference
stoichiometry: 1.0
species: 631662

712361
type: SpeciesReference
stoichiometry: 1.0
species: 632779

632779
type: Species
initial amount: NaN
initial concentration: 2.6E-4
constant: false
boundary condition: false
name: S-Acetyldihydrolipoamide_m
is: C01136
has only substance units: false
in compartment: 623863
is: http://identifiers.org/pubchem.compound/4367
is: CHEBI:16807

712349
type: SpeciesReference
stoichiometry: 1.0
species: 624811

687149
type: Reaction
is: ENSMUSG00000024177
notes: ATP:nucleoside-diphosphate phosphatransferase Pyrimidine metabolism EC:2.7.4.6
product: 687197
is: ENSMUSG00000035984
is: ENSMUSG00000032478
is: R00570
is: ENSMUSG00000020857
is: ENSMUSG00000073435
product: 687185
reversible: false
reactant: 687173
is: K00940
fast: false
is: ENSMUSG00000026575
reactant: 687161
is: ENSMUSG00000037601
name: r0151

687197
type: SpeciesReference
stoichiometry: 1.0
species: 626227

626227
type: Species
in compartment: 623863
has only substance units: false
name: CTP_m
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3363
is: CHEBI:17677
boundary condition: false
initial amount: NaN
constant: false
is: http://identifiers.org/cas/65-47-4
is: C00063

687185
type: SpeciesReference
stoichiometry: 1.0
species: 624691

687173
type: SpeciesReference
stoichiometry: 1.0
species: 627355

627355
type: Species
is: CHEBI:17239
has only substance units: false
boundary condition: false
name: CDP_m
initial amount: NaN
is: C00112
is: http://identifiers.org/cas/63-38-7
initial concentration: 2.6E-4
constant: false
in compartment: 623863
is: http://identifiers.org/pubchem.compound/3412

687161
type: SpeciesReference
stoichiometry: 1.0
species: 624367

667908
type: Constraint
message: Error: Species concentration 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol_r is out of the hard bounds.

654830
type: Constraint
message: Error: Species concentration HMG-CoA_m is out of the hard bounds.

644873
type: Constraint
message: Error: Species concentration H2O2_p is out of the hard bounds.

728132
type: Reaction
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
product: 728179
name: r0820
product: 728167
reactant: 728155
fast: false
reactant: 728144
is: ENSMUSG00000025792

728179
type: SpeciesReference
stoichiometry: 1.0
species: 628123

728167
type: SpeciesReference
stoichiometry: 1.0
species: 625363

728155
type: SpeciesReference
stoichiometry: 1.0
species: 628135

728144
type: SpeciesReference
stoichiometry: 1.0
species: 625339

667152
type: Constraint
message: Warning: Species concentration Nicotinate_D-ribonucleoside_c is out of the soft bounds.

838536
type: Reaction
fast: false
product: 838584
is: ENSMUSG00000032548
reactant: 838560
product: 838596
reactant: 838572
name: r2316
reactant: 838548
product: 838608
reversible: true
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

838584
type: SpeciesReference
stoichiometry: 1.0
species: 639570

639570
type: Species
initial amount: NaN
is: http://identifiers.org/cas/72059-45-1
is: http://identifiers.org/pubchem.compound/4164
constant: false
initial concentration: 2.6E-4
boundary condition: false
in compartment: 623911
name: leukotriene-a4_c
is: C00909
has only substance units: false
is: CHEBI:15651

838560
type: SpeciesReference
stoichiometry: 1.0
species: 629719

838596
type: SpeciesReference
stoichiometry: 1.0
species: 629731

838572
type: SpeciesReference
stoichiometry: 1.0
species: 625915

838548
type: SpeciesReference
stoichiometry: 1.0
species: 639582

639582
type: Species
in compartment: 623935
boundary condition: false
is: C00909
is: http://identifiers.org/cas/72059-45-1
is: CHEBI:15651
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4164
name: leukotriene-a4_s
has only substance units: false
constant: false
initial concentration: 2.6E-4

838608
type: SpeciesReference
stoichiometry: 1.0
species: 625927

779310
type: Reaction
product: 779370
fast: false
name: r1532
is: ENSMUSG00000022822
product: 779382
reactant: 779334
reactant: 779322
product: 779358
reversible: false
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.208.15
reactant: 779346

779370
type: SpeciesReference
stoichiometry: 1.0
species: 624655

779382
type: SpeciesReference
stoichiometry: 1.0
species: 624727

779334
type: SpeciesReference
stoichiometry: 1.0
species: 624331

779322
type: SpeciesReference
stoichiometry: 1.0
species: 639954

779358
type: SpeciesReference
stoichiometry: 1.0
species: 639966

779346
type: SpeciesReference
stoichiometry: 1.0
species: 624259

628723
type: Species
is: http://identifiers.org/cas/72-19-5
in compartment: 623851
is: http://identifiers.org/pubchem.compound/3488
initial concentration: 2.6E-4
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:16857
initial amount: NaN
name: Threonine_l
is: C00188

665917
type: Constraint
message: Error: Species concentration Taurochenodeoxycholate_c is out of the hard bounds.

650535
type: Constraint
message: Error: Species concentration Palmitoyl-CoA_c is out of the hard bounds.

672876
type: Constraint
message: Error: Species concentration Carbonate_c is out of the hard bounds.

672828
type: Constraint
message: Error: Species concentration LacCer-pool_s is out of the hard bounds.

791621
type: Reaction
fast: false
notes: Y+LAT2 Utilized transport
is: ENSMUSG00000031904
reactant: 791645
reversible: false
product: 791669
reactant: 791657
product: 791681
product: 791693
name: r1716
reactant: 791633

791645
type: SpeciesReference
stoichiometry: 1.0
species: 630798

791669
type: SpeciesReference
stoichiometry: 1.0
species: 626251

791657
type: SpeciesReference
stoichiometry: 1.0
species: 633091

791681
type: SpeciesReference
stoichiometry: 1.0
species: 630810

791693
type: SpeciesReference
stoichiometry: 1.0
species: 633079

791633
type: SpeciesReference
stoichiometry: 1.0
species: 626263

660289
type: Constraint
message: Warning: Species concentration NH4+_c is out of the soft bounds.

632743
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/4351
has only substance units: false
name: Sphinganine-1P_c
initial concentration: 2.6E-4
is: C01120
in compartment: 623911
is: CHEBI:16893
initial amount: NaN
boundary condition: false
is: http://identifiers.org/cas/19794-97-9

698824
type: Reaction
reactant: 698836
product: 698872
reversible: false
is: ENSMUSG00000053398
is: K00058
reactant: 698848
name: r0338
product: 698860
fast: false
is: R01513
notes: 3-Phospho-D-glycerate:NAD+ 2-oxidoreductase Glycine, serine and threonine metabolism EC:1.1.1.95

698836
type: SpeciesReference
stoichiometry: 1.0
species: 628795

698872
type: SpeciesReference
stoichiometry: 1.0
species: 624451

698848
type: SpeciesReference
stoichiometry: 1.0
species: 624403

698860
type: SpeciesReference
stoichiometry: 1.0
species: 634147

645629
type: Constraint
message: Warning: Species concentration GTP_s is out of the soft bounds.

656354
type: Constraint
message: Warning: Species concentration dUTP_c is out of the soft bounds.

673212
type: Constraint
message: Error: Species concentration leukotriene-a4_c is out of the hard bounds.

782262
type: Reaction
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: 782286
fast: false
is: ENSMUSG00000040010
product: 782298
reactant: 782274
product: 782310
reversible: true
name: r1578

782286
type: SpeciesReference
stoichiometry: 1.0
species: 627559

782298
type: SpeciesReference
stoichiometry: 1.0
species: 626251

782274
type: SpeciesReference
stoichiometry: 1.0
species: 626263

782310
type: SpeciesReference
stoichiometry: 1.0
species: 627571

676667
type: Constraint
message: Error: Species concentration Collagen_CODA1_c is out of the hard bounds.

740022
type: Reaction
product: 740046
reactant: 740034
notes: Transport reaction
fast: false
reversible: false
name: r1075

740046
type: SpeciesReference
stoichiometry: 1.0
species: 628075

740034
type: SpeciesReference
stoichiometry: 1.0
species: 628099

628099
type: Species
is: CHEBI:17203
is: http://identifiers.org/pubchem.compound/3448
constant: false
has only substance units: false
initial concentration: 2.6E-4
boundary condition: false
initial amount: NaN
name: Proline_l
is: http://identifiers.org/cas/147-85-3
is: C00148
in compartment: 623851

648902
type: Constraint
message: Error: Species concentration Glycerol_c is out of the hard bounds.

645125
type: Constraint
message: Warning: Species concentration Acetate_s is out of the soft bounds.

677267
type: Constraint
message: Error: Species concentration Collagen_PCOTH_c is out of the hard bounds.

639870
type: Species
initial amount: NaN
is: http://identifiers.org/cas/15324-64-8
is: C11301
is: http://identifiers.org/pubchem.compound/443113
has only substance units: false
constant: false
initial concentration: 2.6E-4
boundary condition: false
in compartment: 623935
name: sulfoglycolithocholate_s

653510
type: Constraint
message: Error: Species concentration HCO3-_c is out of the hard bounds.

633379
type: Species
boundary condition: true
name: Lanosterol_p
is: C01724
is: http://identifiers.org/pubchem.compound/4861
initial concentration: 2.6E-4
is: CHEBI:16521
constant: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/cas/79-63-0
in compartment: 623899

871266
type: Reaction
fast: false
reactant: 871446
reactant: 871338
reactant: 871314
reactant: 871398
name: r2598
notes: Collagen alpha-1(X) chain Protein assembly
reactant: 871458
reactant: 871326
reactant: 871482
reactant: 871362
product: 871542
reactant: 871422
reactant: 871290
reversible: false
product: 871578
product: 871554
reactant: 871410
reactant: 871530
product: 871590
reactant: 871386
product: 871566
reactant: 871278
reactant: 871518
reactant: 871374
reactant: 871350
reactant: 871494
reactant: 871470
reactant: 871434
reactant: 871302
is: ENSMUSG00000039462
reactant: 871506

871446
type: SpeciesReference
stoichiometry: 19.0
species: 626155

871338
type: SpeciesReference
stoichiometry: 175.0
species: 625627

871314
type: SpeciesReference
stoichiometry: 22.0
species: 625291

871398
type: SpeciesReference
stoichiometry: 11.0
species: 626407

871458
type: SpeciesReference
stoichiometry: 27.0
species: 626299

871326
type: SpeciesReference
stoichiometry: 15.0
species: 626575

871482
type: SpeciesReference
stoichiometry: 26.0
species: 628531

871362
type: SpeciesReference
stoichiometry: 27.0
species: 630798

871542
type: SpeciesReference
stoichiometry: 1.0
species: 641250

641250
type: Species
is: Q03692
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_COAA1_c

871422
type: SpeciesReference
stoichiometry: 145.0
species: 628075

871290
type: SpeciesReference
stoichiometry: 1.0
species: 627007

871578
type: SpeciesReference
stoichiometry: 680.0
species: 625135

871554
type: SpeciesReference
stoichiometry: 2040.0
species: 624655

871410
type: SpeciesReference
stoichiometry: 14.0
species: 628147

871530
type: SpeciesReference
stoichiometry: 2720.0
species: 624259

871590
type: SpeciesReference
stoichiometry: 680.0
species: 624919

871386
type: SpeciesReference
stoichiometry: 35.0
species: 627559

871566
type: SpeciesReference
stoichiometry: 2040.0
species: 624727

871278
type: SpeciesReference
stoichiometry: 36.0
species: 625675

871518
type: SpeciesReference
stoichiometry: 2720.0
species: 624331

871374
type: SpeciesReference
stoichiometry: 35.0
species: 625819

871350
type: SpeciesReference
stoichiometry: 10.0
species: 627835

871494
type: SpeciesReference
stoichiometry: 2.0
species: 626539

871470
type: SpeciesReference
stoichiometry: 24.0
species: 628699

871434
type: SpeciesReference
stoichiometry: 23.0
species: 626251

871302
type: SpeciesReference
stoichiometry: 12.0
species: 625867

871506
type: SpeciesReference
stoichiometry: 21.0
species: 626695

660925
type: Constraint
message: Error: Species concentration Choloyl-CoA_p is out of the hard bounds.

638754
type: Species
is: C16219
is: http://identifiers.org/pubchem.compound/47205527
in compartment: 623911
initial amount: NaN
boundary condition: false
has only substance units: false
name: 3-Oxostearoyl-ACP_c
constant: false
initial concentration: 2.6E-4

627187
type: Species
is: C00104
constant: false
initial concentration: 2.6E-4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3404
is: CHEBI:17808
in compartment: 623935
has only substance units: false
is: http://identifiers.org/cas/86-04-4
boundary condition: true
name: IDP_s

630966
type: Species
initial concentration: 2.6E-4
is: CHEBI:17549
is: http://identifiers.org/cas/106-60-5
is: http://identifiers.org/pubchem.compound/3719
has only substance units: false
boundary condition: false
is: C00430
initial amount: NaN
constant: false
in compartment: 623863
name: 5-Aminolevulinate_m

666133
type: Constraint
message: Error: Species concentration 2-Amino-3-oxoadipate_m is out of the hard bounds.

677015
type: Constraint
message: Warning: Species concentration Collagen_CORA1_c is out of the soft bounds.

677843
type: Constraint
message: Error: Species concentration CMP_n is out of the hard bounds.

656618
type: Constraint
message: Warning: Species concentration Cystine_c is out of the soft bounds.

782922
type: Reaction
reversible: true
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: 782934
product: 782958
product: 782970
reactant: 782946
name: r1589
is: ENSMUSG00000040010

782934
type: SpeciesReference
stoichiometry: 1.0
species: 626311

782958
type: SpeciesReference
stoichiometry: 1.0
species: 626299

782970
type: SpeciesReference
stoichiometry: 1.0
species: 627019

782946
type: SpeciesReference
stoichiometry: 1.0
species: 627007

647846
type: Constraint
message: Error: Species concentration Glucose-6P_r is out of the hard bounds.

642834
type: Constraint
message: Error: Species concentration NAD+_c is out of the hard bounds.

726308
type: Reaction
is: ENSMUSG00000020097
fast: false
product: 726344
is: R06516
reversible: false
product: 726332
name: r0786
notes: sphinganine-1-phosphate palmitaldehyde-lyase Sphingolipid metabolism EC:4.1.2.27
is: K01634
reactant: 726320

726344
type: SpeciesReference
stoichiometry: 1.0
species: 640530

726332
type: SpeciesReference
stoichiometry: 1.0
species: 630307

630307
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/3639
is: CHEBI:17553
initial concentration: 2.6E-4
in compartment: 623911
initial amount: NaN
is: http://identifiers.org/cas/1071-23-4
constant: false
is: C00346
name: Ethanolamine-P_c
boundary condition: false

726320
type: SpeciesReference
stoichiometry: 1.0
species: 636691

636691
type: Species
is: CHEBI:37550
name: Sphingosine-1P_c
constant: false
initial amount: NaN
is: C06124
in compartment: 623911
initial concentration: 2.6E-4
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/8381

646493
type: Constraint
message: Warning: Species concentration CTP_m is out of the soft bounds.

633955
type: Species
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/5780
initial concentration: 2.6E-4
boundary condition: false
is: C02838
name: L-Octanoylcarnitine_m
in compartment: 623863
is: CHEBI:18102
constant: false

639078
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Adenosylmethioninamine-potential_c

660157
type: Constraint
message: Error: Species concentration Glucono-1,5-lactone-6P_c is out of the hard bounds.

655862
type: Constraint
message: Error: Species concentration cis-Aconitate_c is out of the hard bounds.

699580
type: Reaction
reactant: 699592
reversible: false
reactant: 699604
notes: Thymidylate 5'-phosphohydrolase Pyrimidine metabolism EC:3.1.3.5 EC:3.1.3.35
fast: false
is: ENSMUSG00000032615
is: K08723
name: r0351
is: K01081
is: K11751
is: K08722
is: K03787
is: R01569
product: 699616
product: 699628

699592
type: SpeciesReference
stoichiometry: 1.0
species: 630535

699604
type: SpeciesReference
stoichiometry: 1.0
species: 624295

699616
type: SpeciesReference
stoichiometry: 1.0
species: 629023

629023
type: Species
is: CHEBI:17748
name: Thymidine_m
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/50-89-5
in compartment: 623863
is: C00214
boundary condition: false
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3514

699628
type: SpeciesReference
stoichiometry: 1.0
species: 624763

632611
type: Species
has only substance units: false
boundary condition: false
is: http://identifiers.org/cas/28613-33-4
is: http://identifiers.org/pubchem.compound/4300
is: C01061
constant: false
initial amount: NaN
name: Fumarylacetoacetate_c
initial concentration: 2.6E-4
is: CHEBI:30907
in compartment: 623911

656222
type: Constraint
message: Error: Species concentration Saccharopine_m is out of the hard bounds.

674940
type: Constraint
message: Error: Species concentration prostaglandin-i2_s is out of the hard bounds.

655718
type: Constraint
message: Error: Species concentration Isoleucine_l is out of the hard bounds.

644285
type: Constraint
message: Warning: Species concentration AMP_r is out of the soft bounds.

666684
type: Constraint
message: Error: Species concentration Octanoyl-ACP_c is out of the hard bounds.

704010
type: Reaction
is: R01899
reactant: 704022
is: K00031
is: ENSMUSG00000030541
product: 704046
reversible: true
name: r0423
reactant: 704034
product: 704058
fast: false
notes: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

704022
type: SpeciesReference
stoichiometry: 1.0
species: 629887

629887
type: Species
in compartment: 623863
is: http://identifiers.org/pubchem.compound/3605
is: C00311
initial amount: NaN
constant: false
name: Isocitrate_m
initial concentration: 3.8E-5
has only substance units: false
is: CHEBI:30887
is: http://identifiers.org/cas/320-77-4
boundary condition: false

704046
type: SpeciesReference
stoichiometry: 1.0
species: 635587

635587
type: Species
is: CHEBI:7815
is: http://identifiers.org/cas/1948-82-9
name: Oxalosuccinate_m
is: C05379
has only substance units: false
boundary condition: false
in compartment: 623863
initial concentration: 2.6E-5
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7753
constant: false

704034
type: SpeciesReference
stoichiometry: 1.0
species: 624559

704058
type: SpeciesReference
stoichiometry: 1.0
species: 624511

677135
type: Constraint
message: Warning: Species concentration Collagen_FCN2_c is out of the soft bounds.

772471
type: Reaction
product: 772519
product: 772507
reactant: 772495
reactant: 772483
notes: Transport reaction
fast: false
reversible: false
name: r1424

772519
type: SpeciesReference
stoichiometry: 1.0
species: 626647

772507
type: SpeciesReference
stoichiometry: 1.0
species: 628111

772495
type: SpeciesReference
stoichiometry: 1.0
species: 626623

772483
type: SpeciesReference
stoichiometry: 1.0
species: 628075

759166
type: Reaction
is: ENSMUSG00000021786
is: K09458
fast: false
product: 759226
product: 759214
name: r1313
reversible: true
is: K11533
product: 759202
reactant: 759178
reactant: 759190
is: R07762
is: K00647
notes: 3-oxoacyl-ACP synthase, mitochondrial Polyunsaturated fatty acid biosynthesis EC:2.3.1.85

759226
type: SpeciesReference
stoichiometry: 1.0
species: 624859

759214
type: SpeciesReference
stoichiometry: 1.0
species: 629119

759202
type: SpeciesReference
stoichiometry: 1.0
species: 638754

759178
type: SpeciesReference
stoichiometry: 1.0
species: 636451

636451
type: Species
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/8059
in compartment: 623911
constant: false
initial concentration: 2.6E-4
name: Hexadecanoyl-ACP_c
is: C05764
has only substance units: false

759190
type: SpeciesReference
stoichiometry: 1.0
species: 632983

632983
type: Species
initial amount: NaN
is: C01209
constant: false
has only substance units: false
initial concentration: 2.6E-4
name: Malonyl-ACP_c
is: http://identifiers.org/pubchem.compound/4431
in compartment: 623911
boundary condition: false

637735
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623851
name: PI-pool_l

725348
type: Reaction
is: K00665
reactant: 725360
is: ENSMUSG00000025153
fast: false
product: 725384
name: r0768
is: K00647
reactant: 725372
product: 725396
is: R04963
product: 725408
notes: Decanoyl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) Fatty acid biosynthesis EC:2.3.1.85
reversible: true
is: K11533
is: K00667
is: K09458

725360
type: SpeciesReference
stoichiometry: 1.0
species: 636343

636343
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 2.6E-4
name: Decanoyl-ACP_c
in compartment: 623911
is: C05755
boundary condition: false
is: http://identifiers.org/pubchem.compound/8050

725384
type: SpeciesReference
stoichiometry: 1.0
species: 636355

636355
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 2.6E-4
is: C05756
in compartment: 623911
name: 3-Oxododecanoyl-ACP_c
is: http://identifiers.org/pubchem.compound/8051

725372
type: SpeciesReference
stoichiometry: 1.0
species: 632983

725396
type: SpeciesReference
stoichiometry: 1.0
species: 624859

725408
type: SpeciesReference
stoichiometry: 1.0
species: 629119

671376
type: Constraint
message: Warning: Species concentration Phosphatidate-Bile-PC-pool_c is out of the soft bounds.

686177
type: Reaction
name: r0136
is: K13809
is: K13799
notes: ATP:CMP phosphotransferase Pyrimidine metabolism EC:2.7.4.14
product: 686213
product: 686225
reversible: true
is: K00945
is: ENSMUSG00000028719
is: K13800
reactant: 686201
reactant: 686189
fast: false
is: R00512

686213
type: SpeciesReference
stoichiometry: 1.0
species: 624655

686225
type: SpeciesReference
stoichiometry: 1.0
species: 627331

627331
type: Species
initial concentration: 2.6E-4
is: C00112
constant: false
is: http://identifiers.org/pubchem.compound/3412
has only substance units: false
boundary condition: false
initial amount: NaN
name: CDP_c
in compartment: 623911
is: http://identifiers.org/cas/63-38-7
is: CHEBI:17239

686201
type: SpeciesReference
stoichiometry: 1.0
species: 626011

686189
type: SpeciesReference
stoichiometry: 1.0
species: 624331

665161
type: Constraint
message: Warning: Species concentration Chenodeoxycholoyl-CoA_r is out of the soft bounds.

851171
type: Reaction
product: 851219
product: 851207
reactant: 851195
reactant: 851183
notes: Utilized transport
fast: false
reversible: true
name: r2513

851219
type: SpeciesReference
stoichiometry: 1.0
species: 636787

851207
type: SpeciesReference
stoichiometry: 1.0
species: 629983

851195
type: SpeciesReference
stoichiometry: 1.0
species: 636799

851183
type: SpeciesReference
stoichiometry: 1.0
species: 629971

695093
type: Reaction
is: ENSMUSG00000073435
product: 695141
is: ENSMUSG00000024177
is: ENSMUSG00000032478
name: r0278
reactant: 695117
is: R01137
is: ENSMUSG00000037601
reactant: 695105
notes: ATP:nucleoside-diphosphate phosphatransferase Purine metabolism EC:2.7.4.6
is: K00940
product: 695129
fast: false
reversible: true
is: ENSMUSG00000026575
is: ENSMUSG00000020857
is: ENSMUSG00000035984

695141
type: SpeciesReference
stoichiometry: 1.0
species: 627751

695117
type: SpeciesReference
stoichiometry: 1.0
species: 628855

695105
type: SpeciesReference
stoichiometry: 1.0
species: 624331

695129
type: SpeciesReference
stoichiometry: 1.0
species: 624655

667476
type: Constraint
message: Error: Species concentration 2,5-Diamino-6-(5-triphosphoryl-3,4-trihydroxy-2-oxopentyl)-_amino-4-oxopyrimidine_c is out of the hard bounds.

798256
type: Reaction
product: 798328
is: ENSMUSG00000031904
product: 798304
notes: Y+LAT2 Utilized transport
name: r1795
fast: false
reactant: 798268
reversible: false
reactant: 798280
reactant: 798292
product: 798316

798328
type: SpeciesReference
stoichiometry: 1.0
species: 633079

798304
type: SpeciesReference
stoichiometry: 1.0
species: 627007

798268
type: SpeciesReference
stoichiometry: 1.0
species: 627019

798280
type: SpeciesReference
stoichiometry: 1.0
species: 626299

798292
type: SpeciesReference
stoichiometry: 1.0
species: 633091

798316
type: SpeciesReference
stoichiometry: 1.0
species: 626311

650042
type: Constraint
message: Warning: Species concentration 3-Methyl-2-oxobutyrate_m is out of the soft bounds.

639354
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623935
name: GM1-pool_s

735486
type: Reaction
product: 735510
reactant: 735498
notes: Transport reaction
fast: false
reversible: true
name: r0979

735510
type: SpeciesReference
stoichiometry: 1.0
species: 632947

632947
type: Species
has only substance units: false
initial concentration: 2.6E-4
name: D-3-Amino-isobutanoate_c
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4429
constant: false
is: CHEBI:16320
is: C01205
in compartment: 623911

735498
type: SpeciesReference
stoichiometry: 1.0
species: 632959

632959
type: Species
is: C01205
has only substance units: false
initial concentration: 2.6E-4
boundary condition: true
in compartment: 623935
constant: false
initial amount: NaN
is: CHEBI:16320
is: http://identifiers.org/pubchem.compound/4429
name: D-3-Amino-isobutanoate_s

638622
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1-Acylglycerol-3P-Bile-PC-pool_c

666001
type: Constraint
message: Warning: Species concentration Glycochenodeoxycholate_b is out of the soft bounds.

702879
type: Reaction
name: r0404
reversible: false
fast: false
is: ENSMUSG00000022474
product: 702903
is: K01840
is: R01818
reactant: 702891
notes: D-Mannose 6-phosphate 1,6-phosphomutase Fructose and mannose metabolism EC:5.4.2.8
is: ENSMUSG00000022711

702903
type: SpeciesReference
stoichiometry: 1.0
species: 631806

702891
type: SpeciesReference
stoichiometry: 1.0
species: 629623

662185
type: Constraint
message: Warning: Species concentration L-Palmitoylcarnitine_m is out of the soft bounds.

631206
type: Species
in compartment: 623911
is: http://identifiers.org/cas/65-46-3
is: CHEBI:17562
name: Cytidine_c
initial concentration: 2.6E-4
is: C00475
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3758

651758
type: Constraint
message: Error: Species concentration UDP-N-acetyl-D-galactosamine_c is out of the hard bounds.

658514
type: Constraint
message: Warning: Species concentration Pantetheine_c is out of the soft bounds.

798844
type: Reaction
is: ENSMUSG00000031904
product: 798916
reactant: 798880
name: r1802
product: 798904
notes: Y+LAT2 Utilized transport
product: 798892
reactant: 798856
fast: false
reversible: false
reactant: 798868

798916
type: SpeciesReference
stoichiometry: 1.0
species: 633079

798880
type: SpeciesReference
stoichiometry: 1.0
species: 633091

798904
type: SpeciesReference
stoichiometry: 1.0
species: 628159

798892
type: SpeciesReference
stoichiometry: 1.0
species: 627007

798856
type: SpeciesReference
stoichiometry: 1.0
species: 627019

798868
type: SpeciesReference
stoichiometry: 1.0
species: 628147

671772
type: Constraint
message: Error: Species concentration Dihomo-gamma-linolenoyl-CoA_c is out of the hard bounds.

769268
type: Reaction
product: 769292
reactant: 769280
notes: Facilitated diffusion
fast: false
reversible: true
name: r1376

769292
type: SpeciesReference
stoichiometry: 1.0
species: 631230

631230
type: Species
has only substance units: false
is: C00486
is: http://identifiers.org/cas/635-65-4
initial concentration: 2.6E-4
initial amount: NaN
boundary condition: false
is: CHEBI:16990
in compartment: 623923
is: http://identifiers.org/pubchem.compound/3769
constant: false
name: Bilirubin_r

769280
type: SpeciesReference
stoichiometry: 1.0
species: 631242

729175
type: Reaction
product: 729199
reactant: 729187
notes: Free diffusion
fast: false
reversible: true
name: r0841

729199
type: SpeciesReference
stoichiometry: 1.0
species: 628819

628819
type: Species
is: http://identifiers.org/cas/4151-19-3
constant: false
name: Ribulose-5P_r
has only substance units: false
is: CHEBI:17363
initial concentration: 2.6E-4
is: C00199
is: http://identifiers.org/pubchem.compound/3499
initial amount: NaN
boundary condition: false
in compartment: 623923

729187
type: SpeciesReference
stoichiometry: 1.0
species: 628831

839964
type: Reaction
product: 840012
reactant: 840000
name: r2333
reversible: true
reactant: 839988
fast: false
is: ENSMUSG00000032548
reactant: 839976
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: 840036
product: 840024

840012
type: SpeciesReference
stoichiometry: 1.0
species: 640374

840000
type: SpeciesReference
stoichiometry: 1.0
species: 625915

839988
type: SpeciesReference
stoichiometry: 1.0
species: 629719

839976
type: SpeciesReference
stoichiometry: 1.0
species: 640386

840036
type: SpeciesReference
stoichiometry: 1.0
species: 625927

840024
type: SpeciesReference
stoichiometry: 1.0
species: 629731

635659
type: Species
constant: false
boundary condition: true
has only substance units: false
name: Galactosylglycerol_s
is: http://identifiers.org/pubchem.compound/7768
is: CHEBI:15754
initial concentration: 2.6E-4
is: C05401
in compartment: 623935
initial amount: NaN

643266
type: Constraint
message: Error: Species concentration O2_m is out of the hard bounds.

655694
type: Constraint
message: Error: Species concentration Isoleucine_s is out of the hard bounds.

728191
type: Reaction
reactant: 728215
name: r0821
is: ENSMUSG00000025792
product: 728227
reversible: true
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
product: 728239
reactant: 728203

728215
type: SpeciesReference
stoichiometry: 1.0
species: 625747

728227
type: SpeciesReference
stoichiometry: 1.0
species: 627547

627547
type: Species
is: C00122
constant: false
name: Fumarate_m
in compartment: 623863
is: http://identifiers.org/pubchem.compound/3422
is: http://identifiers.org/cas/110-17-8
initial concentration: 2.6E-4
has only substance units: false
is: CHEBI:18012
initial amount: NaN
boundary condition: false

728239
type: SpeciesReference
stoichiometry: 1.0
species: 625723

728203
type: SpeciesReference
stoichiometry: 1.0
species: 627535

627535
type: Species
boundary condition: false
initial concentration: 2.6E-4
initial amount: NaN
is: C00122
is: http://identifiers.org/pubchem.compound/3422
name: Fumarate_c
in compartment: 623911
constant: false
has only substance units: false
is: CHEBI:18012
is: http://identifiers.org/cas/110-17-8

753419
type: Reaction
is: K13534
is: R02687
product: 753467
reactant: 753431
is: K12298
is: K14075
is: K14073
is: ENSMUSG00000032207
is: K01046
is: K14076
product: 753455
notes: 1,2-Diacyl-sn-glycerol acylhydrolase Glycerolipid metabolism EC:3.1.1.3
fast: false
is: K14074
is: K14452
reversible: false
reactant: 753443
name: r1228

753467
type: SpeciesReference
stoichiometry: 1.0
species: 638430

638430
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Fatty-acid-VLDL-PS-pool_c

753431
type: SpeciesReference
stoichiometry: 1.0
species: 624259

753455
type: SpeciesReference
stoichiometry: 1.0
species: 638502

638502
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1-Acylglycerol-VLDL-PS-pool_c

753443
type: SpeciesReference
stoichiometry: 1.0
species: 638262

668652
type: Constraint
message: Error: Species concentration Palmitolate_r is out of the hard bounds.

734287
type: Reaction
product: 734311
reactant: 734299
notes: Reduced Folate Carrier (RFC) TCDB:2.A.48.2.1
is: ENSMUSG00000040918
fast: false
reversible: false
name: r0951

734311
type: SpeciesReference
stoichiometry: 1.0
species: 630607

734299
type: SpeciesReference
stoichiometry: 1.0
species: 630619

646640
type: Constraint
message: Warning: Species concentration Serine_c is out of the soft bounds.

633823
type: Species
is: C02538
boundary condition: false
initial amount: NaN
is: CHEBI:17474
constant: false
is: http://identifiers.org/pubchem.compound/5545
has only substance units: false
initial concentration: 2.6E-4
in compartment: 623911
name: Estrone_3-sulfate_c

663361
type: Constraint
message: Warning: Species concentration L-1-Pyrroline-3-hydroxy-5-carboxylate_m is out of the soft bounds.

641010
type: Species
is: P02462
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CO4A1_c

652934
type: Constraint
message: Error: Species concentration Pyridoxal_s is out of the hard bounds.

657770
type: Constraint
message: Warning: Species concentration N-Acetyl-D-mannosamine_c is out of the soft bounds.

712193
type: Reaction
is: K14085
reversible: true
is: R02566
product: 712253
is: ENSMUSG00000053644
product: 712241
is: K00130
notes: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
name: r0553
reactant: 712217
fast: false
reactant: 712229
reactant: 712205

712253
type: SpeciesReference
stoichiometry: 1.0
species: 624499

712241
type: SpeciesReference
stoichiometry: 1.0
species: 632095

632095
type: Species
is: http://identifiers.org/cas/107-43-7
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Betaine_c

712217
type: SpeciesReference
stoichiometry: 1.0
species: 631626

631626
type: Species
is: http://identifiers.org/pubchem.compound/249
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Betaine_aldehyde_c

712229
type: SpeciesReference
stoichiometry: 1.0
species: 624547

712205
type: SpeciesReference
stoichiometry: 1.0
species: 624259

643014
type: Constraint
message: Warning: Species concentration NADPH_r is out of the soft bounds.

667356
type: Constraint
message: Error: Species concentration 2-Hydroxybutyrate_c is out of the hard bounds.

672948
type: Constraint
message: Error: Species concentration Zinc_s is out of the hard bounds.

646541
type: Constraint
message: Warning: Species concentration Glutamine_c is out of the soft bounds.

724976
type: Reaction
is: R04954
product: 725000
is: K11533
is: ENSMUSG00000025153
name: r0762
product: 725012
reactant: 724988
notes: (3R)-3-Hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase Fatty acid biosynthesis EC:2.3.1.85
reversible: true
fast: false
is: K00665
is: K00668
is: K02372

725000
type: SpeciesReference
stoichiometry: 1.0
species: 624259

725012
type: SpeciesReference
stoichiometry: 1.0
species: 636259

636259
type: Species
initial amount: NaN
initial concentration: 2.6E-4
constant: false
has only substance units: false
is: C05748
is: http://identifiers.org/pubchem.compound/8043
name: (2E)-Hexenoyl-ACP_c
boundary condition: false
in compartment: 623911

724988
type: SpeciesReference
stoichiometry: 1.0
species: 636247

636247
type: Species
is: http://identifiers.org/pubchem.compound/8042
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 2.6E-4
is: C05747
has only substance units: false
in compartment: 623911
name: D-3-Hydroxyhexanoyl-ACP_c

662065
type: Constraint
message: Warning: Species concentration Isovaleryl-CoA_m is out of the soft bounds.

643806
type: Constraint
message: Warning: Species concentration CO2_m is out of the soft bounds.

648686
type: Constraint
message: Error: Species concentration DHAP_s is out of the hard bounds.

666552
type: Constraint
message: Warning: Species concentration 3-Oxohexanoyl-ACP_c is out of the soft bounds.

787146
type: Reaction
name: r1659
reversible: true
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: ENSMUSG00000040010
fast: false
product: 787182
product: 787194
reactant: 787158
reactant: 787170

787182
type: SpeciesReference
stoichiometry: 1.0
species: 628531

787194
type: SpeciesReference
stoichiometry: 1.0
species: 630810

787158
type: SpeciesReference
stoichiometry: 1.0
species: 628543

787170
type: SpeciesReference
stoichiometry: 1.0
species: 630798

659833
type: Constraint
message: Warning: Species concentration S-Succinyldihydrolipoamide_m is out of the soft bounds.

667104
type: Constraint
message: Warning: Species concentration Bilirubin-bisglucuronoside_c is out of the soft bounds.

870342
type: Reaction
product: 870594
product: 870462
reversible: false
product: 870618
product: 870486
product: 870570
name: r2595
product: 870426
product: 870534
product: 870546
product: 870438
product: 870510
reactant: 870366
product: 870522
fast: false
product: 870390
notes: Protein degradation
product: 870402
product: 870474
product: 870630
product: 870558
product: 870498
product: 870414
reactant: 870378
product: 870582
product: 870450
product: 870606
reactant: 870354

870594
type: SpeciesReference
stoichiometry: 29.0
species: 628531

870462
type: SpeciesReference
stoichiometry: 8.0
species: 627835

870618
type: SpeciesReference
stoichiometry: 344.5
species: 624655

870486
type: SpeciesReference
stoichiometry: 38.0
species: 625819

870570
type: SpeciesReference
stoichiometry: 18.0
species: 626299

870426
type: SpeciesReference
stoichiometry: 31.0
species: 625291

870534
type: SpeciesReference
stoichiometry: 138.0
species: 628075

870546
type: SpeciesReference
stoichiometry: 34.0
species: 626251

870438
type: SpeciesReference
stoichiometry: 4.0
species: 626575

870510
type: SpeciesReference
stoichiometry: 11.0
species: 626407

870366
type: SpeciesReference
stoichiometry: 344.5
species: 624331

870522
type: SpeciesReference
stoichiometry: 6.0
species: 628147

870390
type: SpeciesReference
stoichiometry: 42.0
species: 625675

870402
type: SpeciesReference
stoichiometry: 4.0
species: 627007

870474
type: SpeciesReference
stoichiometry: 23.0
species: 630798

870630
type: SpeciesReference
stoichiometry: 344.5
species: 624727

870558
type: SpeciesReference
stoichiometry: 27.0
species: 626155

870498
type: SpeciesReference
stoichiometry: 28.0
species: 627559

870414
type: SpeciesReference
stoichiometry: 24.0
species: 625867

870378
type: SpeciesReference
stoichiometry: 344.5
species: 624259

870582
type: SpeciesReference
stoichiometry: 15.0
species: 628699

870450
type: SpeciesReference
stoichiometry: 203.0
species: 625627

870606
type: SpeciesReference
stoichiometry: 6.0
species: 626695

870354
type: SpeciesReference
stoichiometry: 1.0
species: 641226

641226
type: Species
is: Q14055
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_CO9A2_c

724124
type: Reaction
reactant: 724136
is: ENSMUSG00000025955
reactant: 724148
is: ENSMUSG00000033715
product: 724172
product: 724160
reversible: true
fast: false
is: ENSMUSG00000021207
is: R04825
is: ENSMUSG00000054757
is: ENSMUSG00000021214
is: ENSMUSG00000021210
is: K00037
name: r0750
notes: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50

724136
type: SpeciesReference
stoichiometry: 1.0
species: 635827

724148
type: SpeciesReference
stoichiometry: 1.0
species: 624547

724172
type: SpeciesReference
stoichiometry: 1.0
species: 635815

724160
type: SpeciesReference
stoichiometry: 1.0
species: 624499

637519
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623851
name: PC-VLDL-pool_l

739842
type: Reaction
product: 739866
reactant: 739854
notes: Transport reaction
fast: false
reversible: true
name: r1070

739866
type: SpeciesReference
stoichiometry: 1.0
species: 625855

625855
type: Species
initial concentration: 2.6E-4
is: C00047
initial amount: NaN
constant: false
boundary condition: false
name: Lysine_m
in compartment: 623863
is: http://identifiers.org/pubchem.compound/3349
has only substance units: false
is: http://identifiers.org/cas/56-87-1
is: CHEBI:18019

739854
type: SpeciesReference
stoichiometry: 1.0
species: 625819

683849
type: Reaction
is: ENSMUSG00000027605
product: 683885
is: K01895
name: r0097
reactant: 683873
is: ENSMUSG00000027452
fast: false
reversible: false
reactant: 683861
notes: Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
product: 683897
is: R00316

683885
type: SpeciesReference
stoichiometry: 1.0
species: 624919

683873
type: SpeciesReference
stoichiometry: 1.0
species: 625531

683861
type: SpeciesReference
stoichiometry: 1.0
species: 624331

683897
type: SpeciesReference
stoichiometry: 1.0
species: 636667

840288
type: Reaction
product: 840312
reactant: 840300
notes: Major Facilitator(MFS) TCDB:2.A.1.19.1
is: ENSMUSG00000023829
fast: false
reversible: true
name: r2338

840312
type: SpeciesReference
stoichiometry: 1.0
species: 633583

840300
type: SpeciesReference
stoichiometry: 1.0
species: 633595

633595
type: Species
is: http://identifiers.org/cas/51-84-3
initial amount: NaN
constant: false
is: CHEBI:15355
has only substance units: false
is: http://identifiers.org/pubchem.compound/5093
is: C01996
boundary condition: false
name: Acetylcholine_s
initial concentration: 2.6E-4
in compartment: 623935

627703
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 2.6E-4
in compartment: 623875
is: http://identifiers.org/cas/3063-71-6
name: CMP-N-acetylneuraminate_n
is: http://identifiers.org/pubchem.compound/3428
is: CHEBI:16556
boundary condition: false
constant: false
is: C00128

639222
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Glycogenin-G7_c

726860
type: Reaction
product: 726908
product: 726896
reactant: 726884
reactant: 726872
notes: Spontaneous reaction
fast: false
reversible: false
name: r0795

726908
type: SpeciesReference
stoichiometry: 1.0
species: 629647

726896
type: SpeciesReference
stoichiometry: 1.0
species: 626107

726884
type: SpeciesReference
stoichiometry: 1.0
species: 636043

726872
type: SpeciesReference
stoichiometry: 1.0
species: 624259

819060
type: Reaction
reactant: 819084
reversible: false
product: 819096
reactant: 819072
name: r2062
product: 819108
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is: ENSMUSG00000030492

819084
type: SpeciesReference
stoichiometry: 1.0
species: 626575

819096
type: SpeciesReference
stoichiometry: 1.0
species: 630067

819072
type: SpeciesReference
stoichiometry: 1.0
species: 630079

819108
type: SpeciesReference
stoichiometry: 1.0
species: 626587

644369
type: Constraint
message: Error: Species concentration AMP_p is out of the hard bounds.

649862
type: Constraint
message: Error: Species concentration Butyryl-CoA_m is out of the hard bounds.

756467
type: Reaction
product: 756491
reactant: 756479
notes: Transport reaction
fast: false
reversible: false
name: r1274

756491
type: SpeciesReference
stoichiometry: 1.0
species: 637711

756479
type: SpeciesReference
stoichiometry: 1.0
species: 637735

885555
type: Reaction
product: 885651
product: 885615
product: 885831
reversible: false
reactant: 885579
product: 885807
reactant: 885591
product: 885723
product: 885687
product: 885795
product: 885699
product: 885759
product: 885663
product: 885627
product: 885735
product: 885843
product: 885819
name: r2641
product: 885603
fast: false
product: 885771
product: 885711
product: 885675
product: 885639
notes: Protein degradation
product: 885783
product: 885747
reactant: 885567
product: 885855

885651
type: SpeciesReference
stoichiometry: 4.0
species: 626575

885615
type: SpeciesReference
stoichiometry: 13.0
species: 627007

885831
type: SpeciesReference
stoichiometry: 8.0
species: 626695

885579
type: SpeciesReference
stoichiometry: 220.5
species: 624331

885807
type: SpeciesReference
stoichiometry: 21.0
species: 628531

885591
type: SpeciesReference
stoichiometry: 220.5
species: 624259

885723
type: SpeciesReference
stoichiometry: 6.0
species: 626407

885687
type: SpeciesReference
stoichiometry: 7.0
species: 630798

885795
type: SpeciesReference
stoichiometry: 23.0
species: 628699

885699
type: SpeciesReference
stoichiometry: 12.0
species: 625819

885759
type: SpeciesReference
stoichiometry: 18.0
species: 626251

885663
type: SpeciesReference
stoichiometry: 65.0
species: 625627

885627
type: SpeciesReference
stoichiometry: 16.0
species: 625867

885735
type: SpeciesReference
stoichiometry: 10.0
species: 628147

885843
type: SpeciesReference
stoichiometry: 220.5
species: 624655

885819
type: SpeciesReference
stoichiometry: 5.0
species: 626539

885603
type: SpeciesReference
stoichiometry: 38.0
species: 625675

885771
type: SpeciesReference
stoichiometry: 28.0
species: 626155

885711
type: SpeciesReference
stoichiometry: 39.0
species: 627559

885675
type: SpeciesReference
stoichiometry: 7.0
species: 627835

885639
type: SpeciesReference
stoichiometry: 24.0
species: 625291

885783
type: SpeciesReference
stoichiometry: 29.0
species: 626299

885747
type: SpeciesReference
stoichiometry: 68.0
species: 628075

885567
type: SpeciesReference
stoichiometry: 1.0
species: 641502

641502
type: Species
is: Q96A83
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_EMID2_c

885855
type: SpeciesReference
stoichiometry: 220.5
species: 624727

824447
type: Reaction
is: ENSMUSG00000079262
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: 824507
reactant: 824459
is: ENSMUSG00000041698
reactant: 824483
reversible: true
product: 824495
name: r2149
reactant: 824471
fast: false
product: 824519
is: ENSMUSG00000030237
is: ENSMUSG00000063975

824507
type: SpeciesReference
stoichiometry: 1.0
species: 629731

824459
type: SpeciesReference
stoichiometry: 1.0
species: 639870

824483
type: SpeciesReference
stoichiometry: 1.0
species: 625915

824495
type: SpeciesReference
stoichiometry: 1.0
species: 639858

639858
type: Species
is: C11301
name: sulfoglycolithocholate_c
constant: false
boundary condition: false
is: http://identifiers.org/cas/15324-64-8
has only substance units: false
initial concentration: 2.6E-4
in compartment: 623911
is: http://identifiers.org/pubchem.compound/443113
initial amount: NaN

824471
type: SpeciesReference
stoichiometry: 1.0
species: 629719

824519
type: SpeciesReference
stoichiometry: 1.0
species: 625927

830075
type: Reaction
reactant: 830111
is: ENSMUSG00000063975
fast: false
name: r2216
product: 830135
reactant: 830099
reactant: 830087
is: ENSMUSG00000041698
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000030237
reversible: true
product: 830147
is: ENSMUSG00000079262
product: 830123

830111
type: SpeciesReference
stoichiometry: 1.0
species: 639954

830135
type: SpeciesReference
stoichiometry: 1.0
species: 629731

830099
type: SpeciesReference
stoichiometry: 1.0
species: 629719

830087
type: SpeciesReference
stoichiometry: 1.0
species: 640266

640266
type: Species
has only substance units: false
initial concentration: 2.6E-4
is: http://identifiers.org/cas/363-24-6
name: prostaglandin-e2_s
is: C00584
is: CHEBI:15551
is: http://identifiers.org/pubchem.compound/3863
in compartment: 623935
constant: false
initial amount: NaN
boundary condition: false

830147
type: SpeciesReference
stoichiometry: 1.0
species: 639966

830123
type: SpeciesReference
stoichiometry: 1.0
species: 640254

640254
type: Species
is: http://identifiers.org/cas/363-24-6
is: C00584
initial concentration: 2.6E-4
is: CHEBI:15551
name: prostaglandin-e2_c
in compartment: 623911
constant: false
is: http://identifiers.org/pubchem.compound/3863
initial amount: NaN
boundary condition: false
has only substance units: false

742074
type: Reaction
reactant: 742122
product: 742362
reactant: 742218
product: 742385
reversible: false
reactant: 742158
reactant: 742146
fast: false
notes: NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 Protein assembly
reactant: 742314
product: 742338
product: 742350
reactant: 742170
product: 742374
reactant: 742326
reactant: 742086
is: ENSMUSG00000030869
reactant: 742242
reactant: 742230
reactant: 742194
reactant: 742182
reactant: 742098
reactant: 742302
reactant: 742266
reactant: 742254
reactant: 742110
name: r1096
reactant: 742206
reactant: 742290
reactant: 742278
reactant: 742134

742122
type: SpeciesReference
stoichiometry: 3.0
species: 626575

742362
type: SpeciesReference
stoichiometry: 124.0
species: 624919

742218
type: SpeciesReference
stoichiometry: 9.0
species: 626155

742385
type: SpeciesReference
stoichiometry: 372.0
species: 624727

742158
type: SpeciesReference
stoichiometry: 4.0
species: 630798

742146
type: SpeciesReference
stoichiometry: 1.0
species: 627835

742314
type: SpeciesReference
stoichiometry: 4.0
species: 625819

742338
type: SpeciesReference
stoichiometry: 1.0
species: 634363

634363
type: Species
is: C03688
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Apo-ACP_c

742350
type: SpeciesReference
stoichiometry: 124.0
species: 625135

742170
type: SpeciesReference
stoichiometry: 20.0
species: 627559

742374
type: SpeciesReference
stoichiometry: 372.0
species: 624655

742326
type: SpeciesReference
stoichiometry: 1.0
species: 628147

742086
type: SpeciesReference
stoichiometry: 11.0
species: 625675

742242
type: SpeciesReference
stoichiometry: 6.0
species: 628699

742230
type: SpeciesReference
stoichiometry: 8.0
species: 626299

742194
type: SpeciesReference
stoichiometry: 9.0
species: 628075

742182
type: SpeciesReference
stoichiometry: 5.0
species: 626407

742098
type: SpeciesReference
stoichiometry: 2.0
species: 627007

742302
type: SpeciesReference
stoichiometry: 8.0
species: 625867

742266
type: SpeciesReference
stoichiometry: 4.0
species: 626695

742254
type: SpeciesReference
stoichiometry: 11.0
species: 628531

742110
type: SpeciesReference
stoichiometry: 5.0
species: 625291

742206
type: SpeciesReference
stoichiometry: 7.0
species: 626251

742290
type: SpeciesReference
stoichiometry: 496.0
species: 624259

742278
type: SpeciesReference
stoichiometry: 496.0
species: 624331

742134
type: SpeciesReference
stoichiometry: 6.0
species: 625627

879377
type: Reaction
reactant: 879389
product: 879437
product: 879497
reactant: 879413
product: 879581
product: 879545
notes: Protein degradation
fast: false
product: 879605
product: 879641
product: 879593
product: 879461
product: 879677
product: 879425
product: 879533
product: 879569
product: 879629
reversible: false
product: 879665
product: 879485
name: r2623
reactant: 879401
product: 879449
product: 879521
product: 879617
product: 879653
product: 879473
product: 879557
product: 879509

879389
type: SpeciesReference
stoichiometry: 1.0
species: 641394

641394
type: Species
is: Q96P44
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: Collagen_COLA1_c

879437
type: SpeciesReference
stoichiometry: 14.0
species: 627007

879497
type: SpeciesReference
stoichiometry: 11.0
species: 627835

879413
type: SpeciesReference
stoichiometry: 478.5
species: 624259

879581
type: SpeciesReference
stoichiometry: 51.0
species: 626251

879545
type: SpeciesReference
stoichiometry: 12.0
species: 626407

879605
type: SpeciesReference
stoichiometry: 50.0
species: 626299

879641
type: SpeciesReference
stoichiometry: 4.0
species: 626539

879593
type: SpeciesReference
stoichiometry: 38.0
species: 626155

879461
type: SpeciesReference
stoichiometry: 50.0
species: 625291

879677
type: SpeciesReference
stoichiometry: 478.5
species: 624727

879425
type: SpeciesReference
stoichiometry: 40.0
species: 625675

879533
type: SpeciesReference
stoichiometry: 66.0
species: 627559

879569
type: SpeciesReference
stoichiometry: 106.0
species: 628075

879629
type: SpeciesReference
stoichiometry: 53.0
species: 628531

879665
type: SpeciesReference
stoichiometry: 478.5
species: 624655

879485
type: SpeciesReference
stoichiometry: 181.0
species: 625627

879401
type: SpeciesReference
stoichiometry: 478.5
species: 624331

879449
type: SpeciesReference
stoichiometry: 48.0
species: 625867

879521
type: SpeciesReference
stoichiometry: 68.0
species: 625819

879617
type: SpeciesReference
stoichiometry: 34.0
species: 628699

879653
type: SpeciesReference
stoichiometry: 22.0
species: 626695

879473
type: SpeciesReference
stoichiometry: 29.0
species: 626575

879557
type: SpeciesReference
stoichiometry: 26.0
species: 628147

879509
type: SpeciesReference
stoichiometry: 54.0
species: 630798

787806
type: Reaction
fast: false
product: 787842
reversible: true
reactant: 787818
name: r1670
notes: Y+LAT2 Utilized transport
product: 787854
reactant: 787830
is: ENSMUSG00000031904

787842
type: SpeciesReference
stoichiometry: 1.0
species: 626503

787818
type: SpeciesReference
stoichiometry: 1.0
species: 626515

787854
type: SpeciesReference
stoichiometry: 1.0
species: 627847

787830
type: SpeciesReference
stoichiometry: 1.0
species: 627835

818580
type: Reaction
reactant: 818604
fast: false
is: ENSMUSG00000030492
reversible: false
name: r2054
product: 818628
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: 818616
reactant: 818592

818604
type: SpeciesReference
stoichiometry: 1.0
species: 629551

818628
type: SpeciesReference
stoichiometry: 1.0
species: 629563

818616
type: SpeciesReference
stoichiometry: 1.0
species: 627835

818592
type: SpeciesReference
stoichiometry: 1.0
species: 627847

804093
type: Reaction
fast: false
product: 804171
reactant: 804119
product: 804158
name: r1864
reversible: false
reactant: 804132
product: 804145
notes: Y+LAT2 Utilized transport
reactant: 804106
is: ENSMUSG00000031904

804171
type: SpeciesReference
stoichiometry: 1.0
species: 633079

804119
type: SpeciesReference
stoichiometry: 1.0
species: 628699

804158
type: SpeciesReference
stoichiometry: 1.0
species: 628711

804132
type: SpeciesReference
stoichiometry: 1.0
species: 633091

804145
type: SpeciesReference
stoichiometry: 1.0
species: 628531

804106
type: SpeciesReference
stoichiometry: 1.0
species: 628543

682756
type: Reaction
name: r0079
reactant: 682804
is: ENSMUSG00000031090
fast: false
reactant: 682792
reversible: false
reactant: 682768
product: 682816
product: 682852
product: 682840
reactant: 682780
product: 682828
is: R00257
notes: Deamido-NAD+:L-glutamine amido-ligase (AMP-forming) Glutamate metabolism / Nicotinate and nicotinamide metabolism EC:6.3.5.1
is: K01950

682804
type: SpeciesReference
stoichiometry: 1.0
species: 632251

632251
type: Species
is: http://identifiers.org/pubchem.compound/4114
boundary condition: false
is: CHEBI:18304
has only substance units: false
initial amount: NaN
is: C00857
initial concentration: 2.6E-4
name: Deamido-NAD_c
in compartment: 623911
constant: false

682792
type: SpeciesReference
stoichiometry: 1.0
species: 624259

682768
type: SpeciesReference
stoichiometry: 1.0
species: 624331

682816
type: SpeciesReference
stoichiometry: 1.0
species: 625135

682852
type: SpeciesReference
stoichiometry: 1.0
species: 625291

682840
type: SpeciesReference
stoichiometry: 1.0
species: 624403

682780
type: SpeciesReference
stoichiometry: 1.0
species: 626251

682828
type: SpeciesReference
stoichiometry: 1.0
species: 624919

649610
type: Constraint
message: Warning: Species concentration dATP_m is out of the soft bounds.

655538
type: Constraint
message: Warning: Species concentration Guanosine_m is out of the soft bounds.

710657
type: Reaction
reactant: 710681
notes: ATP:nucleoside-diphosphate phosphatransferase Pyrimidine metabolism EC:2.7.4.6
is: ENSMUSG00000024177
name: r0528
is: K00940
is: ENSMUSG00000032478
reactant: 710669
is: ENSMUSG00000020857
is: ENSMUSG00000026575
is: R02326
product: 710693
product: 710705
reversible: true
fast: false
is: ENSMUSG00000035984
is: ENSMUSG00000073435
is: ENSMUSG00000037601

710681
type: SpeciesReference
stoichiometry: 1.0
species: 632035

710669
type: SpeciesReference
stoichiometry: 1.0
species: 624331

710693
type: SpeciesReference
stoichiometry: 1.0
species: 624655

710705
type: SpeciesReference
stoichiometry: 1.0
species: 631098

631098
type: Species
is: http://identifiers.org/cas/2056-98-6
has only substance units: false
initial concentration: 2.6E-4
name: dCTP_c
is: CHEBI:16311
initial amount: NaN
constant: false
is: C00458
boundary condition: true
in compartment: 623911
is: http://identifiers.org/pubchem.compound/3742

672216
type: Constraint
message: Warning: Species concentration Chitin-component_s is out of the soft bounds.

640026
type: Species
name: prostaglandin-a1_s
initial concentration: 2.6E-4
boundary condition: false
is: http://identifiers.org/pubchem.compound/7266
is: CHEBI:15545
is: C04685
is: http://identifiers.org/cas/14152-28-4
constant: false
in compartment: 623935
has only substance units: false
initial amount: NaN

641778
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623863
name: THF-activated_methylene_group_m

634423
type: Species
is: C03758
in compartment: 623935
name: Dopamine_s
constant: false
is: http://identifiers.org/pubchem.compound/6517
is: CHEBI:18243
initial concentration: 2.6E-4
has only substance units: false
boundary condition: true
initial amount: NaN
is: http://identifiers.org/cas/51-61-6

689405
type: Reaction
is: K01963
reversible: false
is: R00742
is: K02160
reactant: 689417
is: K11262
is: K01961
is: ENSMUSG00000042010
name: r0185
fast: false
product: 689465
is: K01962
product: 689453
is: ENSMUSG00000020532
product: 689477
reactant: 689429
reactant: 689441
notes: Acetyl-CoA:carbon-dioxide ligase (ADP-forming) Tetracycline biosynthesis / Pyruvate metabolism / Propanoate metabolism EC:6.4.1.2

689417
type: SpeciesReference
stoichiometry: 1.0
species: 624367

689465
type: SpeciesReference
stoichiometry: 1.0
species: 624763

689453
type: SpeciesReference
stoichiometry: 1.0
species: 624691

689477
type: SpeciesReference
stoichiometry: 1.0
species: 626767

626767
type: Species
initial amount: NaN
initial concentration: 2.6E-4
is: CHEBI:15531
boundary condition: false
in compartment: 623863
name: Malonyl-CoA_m
is: http://identifiers.org/pubchem.compound/3383
has only substance units: false
constant: false
is: C00083
is: http://identifiers.org/cas/524-14-1

689429
type: SpeciesReference
stoichiometry: 1.0
species: 625267

689441
type: SpeciesReference
stoichiometry: 1.0
species: 629743

653366
type: Constraint
message: Error: Species concentration H2S_c is out of the hard bounds.

737970
type: Reaction
reversible: false
fast: false
name: r1026
reactant: 737994
product: 738018
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.201.2
reactant: 737982
is: ENSMUSG00000027048
product: 738030
product: 738042
reactant: 738006

737994
type: SpeciesReference
stoichiometry: 2.0
species: 624259

738018
type: SpeciesReference
stoichiometry: 2.0
species: 624655

737982
type: SpeciesReference
stoichiometry: 2.0
species: 624331

738030
type: SpeciesReference
stoichiometry: 2.0
species: 624727

738042
type: SpeciesReference
stoichiometry: 1.0
species: 635959

738006
type: SpeciesReference
stoichiometry: 1.0
species: 635971

635971
type: Species
is: CHEBI:36274
name: Glycochenodeoxycholate_c
is: http://identifiers.org/cas/640-79-9
initial concentration: 2.6E-4
constant: false
is: C05466
boundary condition: false
in compartment: 623911
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7826

810073
type: Reaction
notes: Y+LAT2 Utilized transport
reactant: 810085
reactant: 810097
fast: false
is: ENSMUSG00000031904
reversible: false
reactant: 810109
name: r1935
product: 810133
product: 810121
product: 810145

810085
type: SpeciesReference
stoichiometry: 1.0
species: 626419

810097
type: SpeciesReference
stoichiometry: 1.0
species: 633091

810109
type: SpeciesReference
stoichiometry: 1.0
species: 627835

810133
type: SpeciesReference
stoichiometry: 1.0
species: 633079

810121
type: SpeciesReference
stoichiometry: 1.0
species: 626407

810145
type: SpeciesReference
stoichiometry: 1.0
species: 627847

676139
type: Constraint
message: Error: Species concentration Collagen_CO4A3_c is out of the hard bounds.

650607
type: Constraint
message: Error: Species concentration Homocysteine_c is out of the hard bounds.

719224
type: Reaction
is: R04225
reactant: 719236
reactant: 719248
name: r0670
notes: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
reversible: false
is: ENSMUSG00000032263
fast: false
product: 719260
product: 719272
is: ENSMUSG00000060376

719236
type: SpeciesReference
stoichiometry: 1.0
species: 634291

719248
type: SpeciesReference
stoichiometry: 1.0
species: 629347

719260
type: SpeciesReference
stoichiometry: 1.0
species: 635059

635059
type: Species
in compartment: 623863
name: S-(2-Methylbutanoyl)-dihydrolipoamide_m
constant: false
boundary condition: false
is: C05118
initial amount: NaN
is: CHEBI:28692
initial concentration: 2.6E-4
has only substance units: false
is: http://identifiers.org/pubchem.compound/7542

719272
type: SpeciesReference
stoichiometry: 1.0
species: 624883

683369
type: Reaction
is: ENSMUSG00000004341
is: ENSMUSG00000004344
is: ENSMUSG00000063856
is: ENSMUSG00000028597
product: 683405
name: r0089
notes: Glutathione:hydrogen-peroxide oxidoreductase Glutathione metabolism EC:1.11.1.9
reactant: 683381
is: R00274
product: 683417
reactant: 683393
fast: false
is: K00432
is: ENSMUSG00000042808
reversible: false
is: ENSMUSG00000018339

683405
type: SpeciesReference
stoichiometry: 1.0
species: 627679

683381
type: SpeciesReference
stoichiometry: 1.0
species: 625411

625411
type: Species
boundary condition: false
has only substance units: false
in compartment: 623863
constant: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3329
is: http://identifiers.org/cas/7722-84-1
is: CHEBI:16240
is: C00027
name: H2O2_m
initial amount: NaN

683417
type: SpeciesReference
stoichiometry: 2.0
species: 624295

683393
type: SpeciesReference
stoichiometry: 2.0
species: 625939

651290
type: Constraint
message: Warning: Species concentration L-Lactate_s is out of the soft bounds.

673380
type: Constraint
message: Error: Species concentration leukotriene-f4_s is out of the hard bounds.

660469
type: Constraint
message: Error: Species concentration Stearate_r is out of the hard bounds.

656534
type: Constraint
message: Error: Species concentration Bilirubin_r is out of the hard bounds.

642066
type: Constraint
message: Error: Species concentration Antitrypsin_c is out of the hard bounds.

644489
type: Constraint
message: Error: Species concentration Pyruvate_p is out of the hard bounds.

651590
type: Constraint
message: Error: Species concentration UDP-xylose_r is out of the hard bounds.

778218
type: Reaction
name: r1519
reactant: 778254
reversible: false
fast: false
product: 778266
reactant: 778230
notes: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is: ENSMUSG00000015243
product: 778290
product: 778278
reactant: 778242

778254
type: SpeciesReference
stoichiometry: 1.0
species: 624259

778266
type: SpeciesReference
stoichiometry: 1.0
species: 633343

633343
type: Species
name: Elaidate_s
is: http://identifiers.org/cas/112-79-8
is: CHEBI:27997
boundary condition: true
initial concentration: 2.6E-4
is: C01712
constant: false
in compartment: 623935
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4850

778230
type: SpeciesReference
stoichiometry: 1.0
species: 633331

633331
type: Species
initial amount: NaN
constant: false
name: Elaidate_c
is: C01712
is: http://identifiers.org/cas/112-79-8
is: http://identifiers.org/pubchem.compound/4850
initial concentration: 2.6E-4
has only substance units: false
is: CHEBI:27997
in compartment: 623911
boundary condition: false

778290
type: SpeciesReference
stoichiometry: 1.0
species: 624727

778278
type: SpeciesReference
stoichiometry: 1.0
species: 624655

778242
type: SpeciesReference
stoichiometry: 1.0
species: 624331

670620
type: Constraint
message: Error: Species concentration 1,2-Diacylglycerol-VLDL-PI-pool_c is out of the hard bounds.

678587
type: Reaction
name: r0013
is: R00022
is: ENSMUSG00000025232
product: 678623
reactant: 678599
fast: false
is: K01207
reactant: 678611
notes: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
is: ENSMUSG00000039307
is: ENSMUSG00000021665
reversible: false

678623
type: SpeciesReference
stoichiometry: 2.0
species: 627967

627967
type: Species
boundary condition: false
name: N-Acetylglucosamine_l
in compartment: 623851
has only substance units: false
is: http://identifiers.org/cas/7512-17-6
initial amount: NaN
constant: false
is: C00140
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3440
is: CHEBI:17411

678599
type: SpeciesReference
stoichiometry: 1.0
species: 633307

633307
type: Species
boundary condition: false
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/656440
constant: false
in compartment: 623851
has only substance units: false
name: Chitobiose_l
is: C01674
is: http://identifiers.org/cas/35061-50-8
initial amount: NaN

678611
type: SpeciesReference
stoichiometry: 1.0
species: 624283

695153
type: Reaction
is: R01137
is: ENSMUSG00000073435
name: r0279
reactant: 695177
is: K00940
is: ENSMUSG00000035984
product: 695189
is: ENSMUSG00000020857
is: ENSMUSG00000032478
notes: ATP:nucleoside-diphosphate phosphatransferase Purine metabolism EC:2.7.4.6
is: ENSMUSG00000026575
product: 695201
fast: false
reversible: true
reactant: 695165
is: ENSMUSG00000024177
is: ENSMUSG00000037601

695177
type: SpeciesReference
stoichiometry: 1.0
species: 628867

628867
type: Species
is: C00206
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3506
boundary condition: false
initial concentration: 2.6E-4
is: CHEBI:16174
constant: false
name: dADP_m
in compartment: 623863

695189
type: SpeciesReference
stoichiometry: 1.0
species: 624691

695201
type: SpeciesReference
stoichiometry: 1.0
species: 627763

627763
type: Species
initial concentration: 2.6E-4
constant: false
has only substance units: false
is: C00131
name: dATP_m
is: CHEBI:16284
in compartment: 623863
is: http://identifiers.org/pubchem.compound/3431
is: http://identifiers.org/cas/1927-31-7
boundary condition: false
initial amount: NaN

695165
type: SpeciesReference
stoichiometry: 1.0
species: 624367

672084
type: Constraint
message: Error: Species concentration NADPH-redox-potential_p is out of the hard bounds.

677315
type: Constraint
message: Error: Species concentration Collagen_SERPH_c is out of the hard bounds.

665281
type: Constraint
message: Warning: Species concentration Oxalosuccinate_p is out of the soft bounds.

665233
type: Constraint
message: Warning: Species concentration Oxalosuccinate_c is out of the soft bounds.

669768
type: Constraint
message: Warning: Species concentration Cholesterol-ester-ol_r is out of the soft bounds.

631014
type: Species
boundary condition: false
is: CHEBI:15638
is: C00445
initial amount: NaN
name: 5,10-Methenyl-THF_c
initial concentration: 2.6E-4
constant: false
in compartment: 623911
is: http://identifiers.org/pubchem.compound/3733
has only substance units: false

838116
type: Reaction
is: ENSMUSG00000063975
product: 838176
reversible: true
product: 838164
reactant: 838140
fast: false
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000079262
product: 838188
is: ENSMUSG00000030237
name: r2311
is: ENSMUSG00000041698
reactant: 838128
reactant: 838152

838176
type: SpeciesReference
stoichiometry: 1.0
species: 629731

838164
type: SpeciesReference
stoichiometry: 1.0
species: 633583

838140
type: SpeciesReference
stoichiometry: 1.0
species: 629719

838188
type: SpeciesReference
stoichiometry: 1.0
species: 625927

838128
type: SpeciesReference
stoichiometry: 1.0
species: 633595

838152
type: SpeciesReference
stoichiometry: 1.0
species: 625915

695717
type: Reaction
reactant: 695741
reactant: 695729
is: K00469
name: r0288
product: 695765
product: 695753
is: R01184
fast: false
reversible: false
is: ENSMUSG00000022613
notes: myo-Inositol:oxygen oxidoreductase Ascorbate and aldarate metabolism / Inositol phosphate metabolism EC:1.13.99.1

695741
type: SpeciesReference
stoichiometry: 1.0
species: 624595

695729
type: SpeciesReference
stoichiometry: 1.0
species: 627919

627919
type: Species
is: C00137
name: Inositol_c
is: http://identifiers.org/pubchem.compound/3437
is: http://identifiers.org/cas/87-89-8
boundary condition: false
has only substance units: false
is: CHEBI:17268
initial concentration: 2.6E-4
in compartment: 623911
initial amount: NaN
constant: false

695765
type: SpeciesReference
stoichiometry: 1.0
species: 628783

628783
type: Species
initial concentration: 2.6E-4
is: C00191
name: Glucuronate_c
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
in compartment: 623911
is: CHEBI:4178
is: http://identifiers.org/pubchem.compound/3491
is: http://identifiers.org/cas/6556-12-3

695753
type: SpeciesReference
stoichiometry: 1.0
species: 624259

746615
type: Reaction
product: 746639
reactant: 746627
notes: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
fast: false
reversible: true
name: r1116

746639
type: SpeciesReference
stoichiometry: 1.0
species: 624343

624343
type: Species
initial amount: NaN
is: CHEBI:15422
is: http://identifiers.org/cas/56-65-5
is: http://identifiers.org/pubchem.compound/3304
is: C00002
constant: false
in compartment: 623935
initial concentration: 3.38E-4
has only substance units: false
boundary condition: true
name: ATP_s

746627
type: SpeciesReference
stoichiometry: 1.0
species: 624331

626839
type: Species
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3386
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: http://identifiers.org/cas/57-13-6
is: CHEBI:16199
in compartment: 623935
name: Urea_s
is: C00086

833749
type: Reaction
reactant: 833785
fast: false
product: 833797
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: 833761
product: 833809
reversible: true
name: r2259
product: 833821
is: ENSMUSG00000030236
reactant: 833773

833785
type: SpeciesReference
stoichiometry: 1.0
species: 639990

833797
type: SpeciesReference
stoichiometry: 1.0
species: 640014

640014
type: Species
boundary condition: false
is: CHEBI:15545
initial concentration: 2.6E-4
constant: false
is: http://identifiers.org/pubchem.compound/7266
name: prostaglandin-a1_c
is: C04685
is: http://identifiers.org/cas/14152-28-4
in compartment: 623911
has only substance units: false
initial amount: NaN

833761
type: SpeciesReference
stoichiometry: 1.0
species: 640026

833809
type: SpeciesReference
stoichiometry: 1.0
species: 629731

833821
type: SpeciesReference
stoichiometry: 1.0
species: 640002

833773
type: SpeciesReference
stoichiometry: 1.0
species: 629719

780162
type: Reaction
reactant: 780186
fast: false
name: r1543
product: 780210
product: 780198
reactant: 780174
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: ENSMUSG00000040010

780186
type: SpeciesReference
stoichiometry: 1.0
species: 625675

780210
type: SpeciesReference
stoichiometry: 1.0
species: 625687

780198
type: SpeciesReference
stoichiometry: 1.0
species: 625627

780174
type: SpeciesReference
stoichiometry: 1.0
species: 625639

662401
type: Constraint
message: Warning: Species concentration CoproporphyrinogenIII_c is out of the soft bounds.

666313
type: Constraint
message: Warning: Species concentration Vanillylmandelate_m is out of the soft bounds.

667932
type: Constraint
message: Error: Species concentration Phosphodimethylethanolamine_c is out of the hard bounds.

647281
type: Constraint
message: Warning: Species concentration Phenylalanine_l is out of the soft bounds.

728455
type: Reaction
product: 728479
reactant: 728467
notes: Postulated transport reaction
fast: false
reversible: true
name: r0827

728479
type: SpeciesReference
stoichiometry: 1.0
species: 627931

627931
type: Species
boundary condition: true
is: CHEBI:17268
initial concentration: 2.6E-4
is: http://identifiers.org/pubchem.compound/3437
is: C00137
is: http://identifiers.org/cas/87-89-8
in compartment: 623935
initial amount: NaN
name: Inositol_s
has only substance units: false
constant: false

728467
type: SpeciesReference
stoichiometry: 1.0
species: 627919

666492
type: Constraint
message: Error: Species concentration Acetoacetyl-ACP_c is out of the hard bounds.

807386
type: Reaction
product: 807446
reactant: 807422
fast: false
reactant: 807410
name: r1903
reversible: false
notes: Y+LAT2 Utilized transport
reactant: 807398
product: 807458
product: 807434
is: ENSMUSG00000031904

807446
type: SpeciesReference
stoichiometry: 1.0
species: 626587

807422
type: SpeciesReference
stoichiometry: 1.0
species: 633091

807410
type: SpeciesReference
stoichiometry: 1.0
species: 626575

807398
type: SpeciesReference
stoichiometry: 1.0
species: 630810

807458
type: SpeciesReference
stoichiometry: 1.0
species: 633079

807434
type: SpeciesReference
stoichiometry: 1.0
species: 630798

641646
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623911
name: Na-gradient_c

646349
type: Constraint
message: Warning: Species concentration Arginine_c is out of the soft bounds.

844487
type: Reaction
reactant: 844511
product: 844535
name: r2410
product: 844559
reversible: true
notes: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: 844547
fast: false
reactant: 844523
reactant: 844499
is: ENSMUSG00000050304

844511
type: SpeciesReference
stoichiometry: 1.0
species: 625855

844535
type: SpeciesReference
stoichiometry: 1.0
species: 630091

844559
type: SpeciesReference
stoichiometry: 1.0
species: 626623

844547
type: SpeciesReference
stoichiometry: 1.0
species: 625819

844523
type: SpeciesReference
stoichiometry: 1.0
species: 626647

844499
type: SpeciesReference
stoichiometry: 1.0
species: 630067

649058
type: Constraint
message: Warning: Species concentration PRPP_c is out of the soft bounds.

753179
type: Reaction
reversible: false
is: ENSMUSG00000032207
product: 753227
notes: EC:3.1.1.3
reactant: 753203
reactant: 753191
product: 753215
name: r1224
fast: false

753227
type: SpeciesReference
stoichiometry: 1.0
species: 638226

638226
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: 1,2-Diacylglycerol-VLDL-TG-pool_c

753203
type: SpeciesReference
stoichiometry: 1.0
species: 624259

753191
type: SpeciesReference
stoichiometry: 1.0
species: 638322

638322
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Triacylglycerol-VLDL-pool_c

753215
type: SpeciesReference
stoichiometry: 1.0
species: 638346

638346
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623911
name: Fatty-acid-VLDL-TG3-pool_c

663481
type: Constraint
message: Warning: Species concentration 2-Amino-3-carboxymuconate_semialdehyde_c is out of the soft bounds.

641946
type: Constraint
message: Error: Species concentration Albumin_s is out of the hard bounds.

738462
type: Reaction
product: 738486
reactant: 738474
notes: Zinc (Zn$^{2+}$)-Iron (Fe$^{2+}$) Permease (ZIP) TCDB:2.A.57.1.1
is: ENSMUSG00000023942
fast: false
reversible: true
name: r1035

738486
type: SpeciesReference
stoichiometry: 1.0
species: 628963

628963
type: Species
is: C00212
constant: false
is: CHEBI:16335
has only substance units: false
is: http://identifiers.org/pubchem.compound/3512
in compartment: 623863
is: http://identifiers.org/cas/58-61-7
boundary condition: false
initial amount: NaN
name: Adenosine_m
initial concentration: 2.6E-4

738474
type: SpeciesReference
stoichiometry: 1.0
species: 628939

718000
type: Reaction
notes: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
name: r0650
fast: false
is: R03974
reactant: 718024
is: ENSMUSG00000030382
reactant: 718012
reactant: 718036
product: 718048
reversible: true
product: 718072
product: 718060

718024
type: SpeciesReference
stoichiometry: 1.0
species: 624787

718012
type: SpeciesReference
stoichiometry: 1.0
species: 624319

718036
type: SpeciesReference
stoichiometry: 1.0
species: 633775

718048
type: SpeciesReference
stoichiometry: 1.0
species: 625123

718072
type: SpeciesReference
stoichiometry: 1.0
species: 635539

635539
type: Species
boundary condition: false
in compartment: 623923
is: C05337
has only substance units: false
initial amount: NaN
is: CHEBI:28701
constant: false
initial concentration: 2.6E-4
name: Chenodeoxycholoyl-CoA_r
is: http://identifiers.org/pubchem.compound/7715

718060
type: SpeciesReference
stoichiometry: 1.0
species: 624907

893211
type: Reaction
product: 893247
product: 893235
reactant: 893223
notes: Virtual reaction/potential definition
fast: false
reversible: true
name: r2670

893247
type: SpeciesReference
stoichiometry: 1.0
species: 641718

641718
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 623911
name: GDP-activated-mannose_c

893235
type: SpeciesReference
stoichiometry: 1.0
species: 625567

893223
type: SpeciesReference
stoichiometry: 1.0
species: 626995

743021
type: Reaction
reactant: 743069
is: ENSMUSG00000002992
reactant: 743129
reactant: 743105
product: 743321
product: 743285
reactant: 743117
reactant: 743081
product: 743309
name: r1099
reactant: 743261
reactant: 743165
reactant: 743141
reactant: 743249
reactant: 743153
reactant: 743093
reactant: 743033
reversible: false
reactant: 743213
reactant: 743189
notes: Apo-CII Protein assembly
product: 743297
reactant: 743201
reactant: 743177
reactant: 743057
reactant: 743237
fast: false
product: 743273
reactant: 743225
reactant: 743045

743069
type: SpeciesReference
stoichiometry: 5.0
species: 625627

743129
type: SpeciesReference
stoichiometry: 5.0
species: 628075

743105
type: SpeciesReference
stoichiometry: 3.0
species: 626407

743321
type: SpeciesReference
stoichiometry: 303.0
species: 624727

743285
type: SpeciesReference
stoichiometry: 101.0
species: 625135

743117
type: SpeciesReference
stoichiometry: 4.0
species: 626575

743081
type: SpeciesReference
stoichiometry: 1.0
species: 630798

743309
type: SpeciesReference
stoichiometry: 303.0
species: 624655

743261
type: SpeciesReference
stoichiometry: 6.0
species: 625819

743165
type: SpeciesReference
stoichiometry: 1.0
species: 626539

743141
type: SpeciesReference
stoichiometry: 9.0
species: 626299

743249
type: SpeciesReference
stoichiometry: 4.0
species: 625867

743153
type: SpeciesReference
stoichiometry: 10.0
species: 628699

743093
type: SpeciesReference
stoichiometry: 15.0
species: 627559

743033
type: SpeciesReference
stoichiometry: 7.0
species: 625675

743213
type: SpeciesReference
stoichiometry: 404.0
species: 624331

743189
type: SpeciesReference
stoichiometry: 7.0
species: 628531

743297
type: SpeciesReference
stoichiometry: 101.0
species: 624919

743201
type: SpeciesReference
stoichiometry: 8.0
species: 625291

743177
type: SpeciesReference
stoichiometry: 5.0
species: 626695

743057
type: SpeciesReference
stoichiometry: 8.0
species: 626251

743237
type: SpeciesReference
stoichiometry: 1.0
species: 628147

743273
type: SpeciesReference
stoichiometry: 1.0
species: 624175

624175
type: Species
is: P02655
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623911
name: ApoC2_c

743225
type: SpeciesReference
stoichiometry: 404.0
species: 624259

743045
type: SpeciesReference
stoichiometry: 2.0
species: 626155

633043
type: Species
in compartment: 623911
is: C01236
name: Glucono-1,5-lactone-6P_c
boundary condition: false
is: CHEBI:16938
initial concentration: 6.0E-4
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/4457
constant: false

773155
type: Reaction
product: 773179
reactant: 773167
notes: Transport reaction
fast: false
reversible: false
name: r1437

773179
type: SpeciesReference
stoichiometry: 1.0
species: 627043

627043
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:17561
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3397
is: C00097
initial concentration: 2.6E-4
is: http://identifiers.org/cas/52-90-4
name: Cysteine_m
in compartment: 623863
constant: false

773167
type: SpeciesReference
stoichiometry: 1.0
species: 627007

662245
type: Constraint
message: Error: Species concentration 5-Phosphoribosylamine_c is out of the hard bounds.

720892
type: Reaction
is: K00667
reversible: true
is: K11533
product: 720928
is: ENSMUSG00000025153
reactant: 720904
is: K00059
is: K00665
reactant: 720916
fast: false
name: r0696
product: 720940
is: R04543
notes: (3R)-3-Hydroxypalmitoyl-[acyl-carrier-protein]:NADP+ oxidoreductase Fatty acid biosynthesis EC:2.3.1.85

720928
type: SpeciesReference
stoichiometry: 1.0
species: 636427

636427
type: Species
initial concentration: 2.6E-4
initial amount: NaN
constant: false
name: 3-Oxohexadecanoyl-ACP_c
is: C05762
in compartment: 623911
is: http://identifiers.org/pubchem.compound/8057
has only substance units: false
boundary condition: false

720904
type: SpeciesReference
stoichiometry: 1.0
species: 634819

634819
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/7222
constant: false
is: C04633
in compartment: 623911
has only substance units: false
name: (R)-3-Hydroxypalmitoyl-ACP_c
initial amount: NaN
initial concentration: 2.6E-4

720916
type: SpeciesReference
stoichiometry: 1.0
species: 624547

720940
type: SpeciesReference
stoichiometry: 1.0
species: 624499

756898
type: Reaction
product: 756982
product: 756994
name: r1281
product: 757006
notes: Particle dis-/assembly
product: 756946
product: 757030
product: 756922
reactant: 756910
product: 756970
reversible: false
product: 757018
product: 756958
fast: false
product: 756934

756982
type: SpeciesReference
stoichiometry: 165.0
species: 637771

756994
type: SpeciesReference
stoichiometry: 185.0
species: 637567

637567
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623851
name: PE-VLDL-pool_l

757006
type: SpeciesReference
stoichiometry: 1.0
species: 624127

756946
type: SpeciesReference
stoichiometry: 2165.0
species: 637519

757030
type: SpeciesReference
stoichiometry: 755.0
species: 637663

637663
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623851
name: SM-pool_l

756922
type: SpeciesReference
stoichiometry: 7.0
species: 624235

624235
type: Species
is: P02649
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-10
initial amount: NaN
in compartment: 623851
name: ApoE_l

756910
type: SpeciesReference
stoichiometry: 1.0
species: 637231

637231
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0E-14
initial amount: NaN
in compartment: 623851
name: VLDL_l

756970
type: SpeciesReference
stoichiometry: 1.0
species: 637735

757018
type: SpeciesReference
stoichiometry: 500.0
species: 628687

756958
type: SpeciesReference
stoichiometry: 1645.0
species: 637255

637255
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623851
name: Cholesterol-ester-pool_l

756934
type: SpeciesReference
stoichiometry: 10385.0
species: 638334

659197
type: Constraint
message: Error: Species concentration 2-Methylbutyryl-CoA_m is out of the hard bounds.

637639
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623887
name: SM-pool_b

705078
type: Reaction
reactant: 705102
is: K08766
reactant: 705090
is: ENSMUSG00000028607
product: 705126
is: R01923
name: r0441
product: 705114
notes: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reversible: true
fast: false
is: K08765
is: ENSMUSG00000024900

705102
type: SpeciesReference
stoichiometry: 1.0
species: 629971

705090
type: SpeciesReference
stoichiometry: 1.0
species: 637411

705126
type: SpeciesReference
stoichiometry: 1.0
species: 640806

640806
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.6E-4
initial amount: NaN
in compartment: 623923
name: Arachidonyl-Carnitine_r

705114
type: SpeciesReference
stoichiometry: 1.0
species: 624787

797500
type: Reaction
product: 797572
reactant: 797536
reactant: 797512
reactant: 797524
name: r1786
is: ENSMUSG00000031904
fast: false
product: 797548
reversible: false
notes: Y+LAT2 Utilized transport
product: 797560

797572
type: SpeciesReference
stoichiometry: 1.0
species: 633079

797536
type: SpeciesReference
stoichiometry: 1.0
species: 633091

797512
type: SpeciesReference
stoichiometry: 1.0
species: 626707

797524
type: SpeciesReference
stoichiometry: 1.0
species: 628075

797548
type: SpeciesReference
stoichiometry: 1.0
species: 626695

797560
type: SpeciesReference
stoichiometry: 1.0
species: 628087

815941
type: Reaction
reactant: 815953
product: 815989
product: 815977
fast: false
notes: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
name: r2010
reactant: 815965
is: ENSMUSG00000030492
reversible: false

815953
type: SpeciesReference
stoichiometry: 1.0
species: 626167

815989
type: SpeciesReference
stoichiometry: 1.0
species: 626263

815977
type: SpeciesReference
stoichiometry: 1.0
species: 626155

815965
type: SpeciesReference
stoichiometry: 1.0
species: 626251

649430
type: Constraint
message: Error: Species concentration GSSG_m is out of the hard bounds.

635035
type: Species
name: 7-Dehydrodesmosterol_r
is: C05107
boundary condition: false
is: CHEBI:27910
initial amount: NaN
constant: false
in compartment: 623923
is: http://identifiers.org/pubchem.compound/7533
initial concentration: 2.6E-4
has only substance units: false

829991
type: Reaction
reversible: true
notes: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: ENSMUSG00000079262
reactant: 830003
name: r2215
is: ENSMUSG00000041698
product: 830051
reactant: 830027
is: ENSMUSG00000030237
reactant: 830015
is: ENSMUSG00000063975
product: 830039
fast: false
product: 830063

830003
type: SpeciesReference
stoichiometry: 1.0
species: 640266

830051
type: SpeciesReference
stoichiometry: 1.0
species: 629731

830027
type: SpeciesReference
stoichiometry: 1.0
species: 639918

830015
type: SpeciesReference
stoichiometry: 1.0
species: 629719

830039
type: SpeciesReference
stoichiometry: 1.0
species: 640254