MODEL1204060000
type: SBMLModel
species: 389341
species: 389329
species: 389233
reaction: 390549
reaction: 389829
reaction: 390405
species: 389305
time units: 291235
reaction: 390465
species: 389449
species: 389353
species: 389185
area units: 061696
reaction: 391124
reaction: 390261
species: 389413
species: 389377
reaction: 389526
reaction: 390777
species: 389209
reaction: 389682
reaction: 389889
species: 389293
species: 389257
reaction: 390920
notes: This model is from the article: Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway. Kubota H, Noguchi R, Toyoshima Y, Ozaki Y, Uda S, Watanabe K, Ogawa W, Kuroda S. Mol Cell. 2012 Jun 29;46(6):820-32. 22633957 , Abstract: One of the unique characteristics of cellular signaling pathways is that a common signaling pathway can selectively regulate multiple cellular functions of a hormone; however, this selective downstream control through a common signaling pathway is poorly understood. Here we show that the insulin-dependent AKT pathway uses temporal patterns multiplexing for selective regulation of downstream molecules. Pulse and sustained insulin stimulations were simultaneously encoded into transient and sustained AKT phosphorylation, respectively. The downstream molecules, including ribosomal protein S6 kinase (S6K), glucose-6-phosphatase (G6Pase), and glycogen synthase kinase-3β (GSK3β) selectively decoded transient, sustained, and both transient and sustained AKT phosphorylation, respectively. Selective downstream decoding is mediated by the molecules' network structures and kinetics. Our results demonstrate that the AKT pathway can multiplex distinct patterns of blood insulin, such as pulse-like additional and sustained-like basal secretions, and the downstream molecules selectively decode secretion patterns of insulin. Note: Created by The MathWorks, Inc. SimBiology tool, Version 3.3
reaction: 389617
length unit: length
species: 389269
reaction: 390033
species: 389365
reaction: 391064
species: 389437
reaction: 390717
compartment: 389173
volume units: 061672
species: 389317
species: 389221
reaction: 390860
is described by: http://identifiers.org/pubmed/22633957
name: Kubota2012_InsulinAction_AKTpathway
reaction: 390177
reaction: 391004
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reaction: 390093
reaction: 389769
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reaction: 389461
reaction: 389949
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reaction: 390633
reaction: 390321

389341
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389173
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389329
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389233
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390549
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390561
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389293
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390621
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390573
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390585
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390597
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389317
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389829
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390429
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390501
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390513
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389353
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390477
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391124
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product: 391148
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391184
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389377
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391160
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389389
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391148
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391136
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390261
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390309
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389245
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390285
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389257
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390273
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389526
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reversible: true
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reactant: 389539
reactant: 389552
name: insulin+IR_complex
kinetic law: 389578
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modifier: 323937

389425
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name: insulin

389565
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389539
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389197
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389552
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389604
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389591
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390777
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390801
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389281
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390824
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389269
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390848
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390813
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390789
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389209
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389682
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product: 389732
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389707
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389757
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389720
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389732
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389695
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389889
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389937
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389913
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389901
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390920
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390968
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389365
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390992
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390956
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390932
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389617
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389669
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389643
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389437
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389630
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390033
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390081
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390057
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389401
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390045
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391064
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391112
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391088
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391076
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390717
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390765
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390741
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390729
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390860
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390908
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390884
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390872
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390177
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390201
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390213
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390189
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390225
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391004
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391052
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391028
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391016
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390093
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390165
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390129
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390105
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389769
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389817
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389793
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389781
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389461
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389513
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389487
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389474
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389949
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389961
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390021
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390633
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390645
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390393
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390345
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