MODEL1202030000
type: SBMLModel
volume units: 122997
species: 261660
reaction: 262073
reaction: 263015
species: 261672
reaction: 262870
reaction: 262217
species: 261550
reaction: 262436
species: 261562
species: 261684
species: 261599
reaction: 262145
units def: 261478
reaction: 261708
reaction: 263088
reaction: 261855
area units: 802883
species: 261574
species: 261611
notes: This model is from the article: A thermodynamic switch modulates abscisic acid receptor sensitivity. Dupeux F, Santiago J, Betz K, Twycross J, Park SY, Rodriguez L, Gonzalez-Guzman M, Jensen MR, Krasnogor N, Blackledge M, Holdsworth M, Cutler SR, Rodriguez PL, Márquez JA EMBO J. [2011 Oct; Volume: 30 (Issue: 20 )] Page info: 4171-84 21847091 , Abstract: Abscisic acid (ABA) is a key hormone regulating plant growth, development and the response to biotic and abiotic stress. ABA binding to pyrabactin resistance (PYR)/PYR1-like (PYL)/Regulatory Component of Abscisic acid Receptor (RCAR) intracellular receptors promotes the formation of stable complexes with certain protein phosphatases type 2C (PP2Cs), leading to the activation of ABA signalling. The PYR/PYL/RCAR family contains 14 genes in Arabidopsis and is currently the largest plant hormone receptor family known; however, it is unclear what functional differentiation exists among receptors. Here, we identify two distinct classes of receptors, dimeric and monomeric, with different intrinsic affinities for ABA and whose differential properties are determined by the oligomeric state of their apo forms. Moreover, we find a residue in PYR1, H60, that is variable between family members and plays a key role in determining oligomeric state. In silico modelling of the ABA activation pathway reveals that monomeric receptors have a competitive advantage for binding to ABA and PP2Cs. This work illustrates how receptor oligomerization can modulate hormonal responses and more generally, the sensitivity of a ligand-dependent signalling system. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger contex…
reaction: 261927
is described by: http://identifiers.org/pubmed/21847091
reaction: 262290
curated: false
time units: 152087
reaction: 262582
reaction: 263379
species: 261623
compartment: 261526
reaction: 263160
substance units: 261502
reaction: 263306
reaction: 262726
reaction: 262798
species: 261696
reaction: 261780
species: 261538
species: 261635
reaction: 262942
reaction: 263233
species: 261586
species: 261647
reaction: 262508
units def: 261502
reaction: 262654
length unit: 802859
reaction: 262363
reaction: 261999
name: Dupeux2011_ABAreceptor_Dimer

261660
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 30111.0
in compartment: 261526
name: RA

261526
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: c0_0

262073
type: Reaction
kinetic law: 262121
product: 262109
product: 262097
reactant: 262085
fast: false
reversible: false
name: re0_0_5

262133
type: LocalParameter
units: 261478
value: 90.0
name: k1

261490
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

262109
type: SpeciesReference
stoichiometry: 1.0
species: 261538

261538
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 261526
name: H

262097
type: SpeciesReference
stoichiometry: 1.0
species: 261672

261672
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 261526
name: RA.RA

262085
type: SpeciesReference
stoichiometry: 1.0
species: 261586

261586
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 261526
name: H.RA.RA

263015
type: Reaction
kinetic law: 263063
product: 263051
reactant: 263039
reactant: 263027
fast: false
reversible: false
name: re0_0_18

263076
type: LocalParameter
units: 261478
value: 1.66053878316273E-5
name: k1

263051
type: SpeciesReference
stoichiometry: 1.0
species: 261562

261562
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 261526
name: H.H.RB.RB

263039
type: SpeciesReference
stoichiometry: 1.0
species: 261611

261611
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 261526
name: H.RB.RB

263027
type: SpeciesReference
stoichiometry: 1.0
species: 261538

262870
type: Reaction
kinetic law: 262918
product: 262906
reactant: 262894
reactant: 262882
fast: false
reversible: false
name: re0_0_16

262930
type: LocalParameter
units: 261478
value: 1.66053878316273E-5
name: k1

262906
type: SpeciesReference
stoichiometry: 1.0
species: 261611

262894
type: SpeciesReference
stoichiometry: 1.0
species: 261696

261696
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 261526
name: RB.RB

262882
type: SpeciesReference
stoichiometry: 1.0
species: 261538

262217
type: Reaction
kinetic law: 262266
product: 262254
product: 262241
reactant: 262229
fast: false
reversible: false
name: re0_0_7

262278
type: LocalParameter
units: 261478
value: 90.0
name: k1

262254
type: SpeciesReference
stoichiometry: 1.0
species: 261586

262241
type: SpeciesReference
stoichiometry: 1.0
species: 261538

262229
type: SpeciesReference
stoichiometry: 1.0
species: 261550

261550
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 261526
name: H.H.RA.RA

262436
type: Reaction
kinetic law: 262484
product: 262472
reactant: 262460
reactant: 262448
fast: false
reversible: false
name: re0_0_10

262496
type: LocalParameter
units: 261478
value: 1.66053878316273E-5
name: k1

262472
type: SpeciesReference
stoichiometry: 1.0
species: 261635

261635
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 261526
name: P.H.RA

262460
type: SpeciesReference
stoichiometry: 1.0
species: 261623

261623
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 60221.0
in compartment: 261526
name: P

262448
type: SpeciesReference
stoichiometry: 1.0
species: 261574

261574
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 261526
name: H.RA

261684
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 30111.0
in compartment: 261526
name: RB

261599
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 261526
name: H.RB

262145
type: Reaction
kinetic law: 262193
product: 262181
reactant: 262169
reactant: 262157
fast: false
reversible: false
name: re0_0_6

262205
type: LocalParameter
units: 261478
value: 1.66053878316273E-5
name: k1

262181
type: SpeciesReference
stoichiometry: 1.0
species: 261550

262169
type: SpeciesReference
stoichiometry: 1.0
species: 261586

262157
type: SpeciesReference
stoichiometry: 1.0
species: 261538

261708
type: Reaction
kinetic law: 261756
product: 261744
reactant: 261732
reactant: 261720
fast: false
reversible: false
name: re0_0_0

261768
type: LocalParameter
units: 261478
value: 3.32107756632545E-5
name: k1

261744
type: SpeciesReference
stoichiometry: 1.0
species: 261672

261732
type: SpeciesReference
stoichiometry: 1.0
species: 261660

261720
type: SpeciesReference
stoichiometry: 1.0
species: 261660

263088
type: Reaction
kinetic law: 263136
product: 263124
product: 263112
reactant: 263100
fast: false
reversible: false
name: re0_0_19

263148
type: LocalParameter
units: 261478
value: 90.0
name: k1

263124
type: SpeciesReference
stoichiometry: 1.0
species: 261611

263112
type: SpeciesReference
stoichiometry: 1.0
species: 261538

263100
type: SpeciesReference
stoichiometry: 1.0
species: 261562

261855
type: Reaction
kinetic law: 261903
product: 261891
reactant: 261879
reactant: 261867
fast: false
reversible: false
name: re0_0_2

261915
type: LocalParameter
units: 261478
value: 1.66053878316273E-5
name: k1

261891
type: SpeciesReference
stoichiometry: 1.0
species: 261574

261879
type: SpeciesReference
stoichiometry: 1.0
species: 261538

261867
type: SpeciesReference
stoichiometry: 1.0
species: 261660

261927
type: Reaction
kinetic law: 261975
product: 261963
product: 261951
reactant: 261939
fast: false
reversible: false
name: re0_0_3

261987
type: LocalParameter
units: 261478
value: 1.5
name: k1

261963
type: SpeciesReference
stoichiometry: 1.0
species: 261538

261951
type: SpeciesReference
stoichiometry: 1.0
species: 261660

261939
type: SpeciesReference
stoichiometry: 1.0
species: 261574

262290
type: Reaction
kinetic law: 262339
product: 262327
reactant: 262315
reactant: 262303
fast: false
reversible: false
name: re0_0_8

262351
type: LocalParameter
units: 261478
value: 1.66053878316273E-5
name: k1

262327
type: SpeciesReference
stoichiometry: 1.0
species: 261550

262315
type: SpeciesReference
stoichiometry: 1.0
species: 261574

262303
type: SpeciesReference
stoichiometry: 1.0
species: 261574

262582
type: Reaction
kinetic law: 262630
product: 262618
reactant: 262606
reactant: 262594
fast: false
reversible: false
name: re0_0_12

262642
type: LocalParameter
units: 261478
value: 3.32107756632545E-5
name: k1

262618
type: SpeciesReference
stoichiometry: 1.0
species: 261696

262606
type: SpeciesReference
stoichiometry: 1.0
species: 261684

262594
type: SpeciesReference
stoichiometry: 1.0
species: 261684

263379
type: Reaction
kinetic law: 263427
product: 263415
product: 263403
reactant: 263391
fast: false
reversible: false
name: re0_0_23

263439
type: LocalParameter
units: 261478
value: 0.02
name: k1

263415
type: SpeciesReference
stoichiometry: 1.0
species: 261599

263403
type: SpeciesReference
stoichiometry: 1.0
species: 261623

263391
type: SpeciesReference
stoichiometry: 1.0
species: 261647

261647
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 261526
name: P.H.RB

263160
type: Reaction
kinetic law: 263208
product: 263196
reactant: 263184
reactant: 263172
fast: false
reversible: false
name: re0_0_20

263221
type: LocalParameter
units: 261478
value: 1.66053878316273E-5
name: k1

263196
type: SpeciesReference
stoichiometry: 1.0
species: 261562

263184
type: SpeciesReference
stoichiometry: 1.0
species: 261599

263172
type: SpeciesReference
stoichiometry: 1.0
species: 261599

261514
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: ITEM

263306
type: Reaction
kinetic law: 263355
product: 263342
reactant: 263330
reactant: 263318
fast: false
reversible: false
name: re0_0_22

263367
type: LocalParameter
units: 261478
value: 1.66053878316273E-5
name: k1

263342
type: SpeciesReference
stoichiometry: 1.0
species: 261647

263330
type: SpeciesReference
stoichiometry: 1.0
species: 261623

263318
type: SpeciesReference
stoichiometry: 1.0
species: 261599

262726
type: Reaction
kinetic law: 262774
product: 262762
reactant: 262750
reactant: 262738
fast: false
reversible: false
name: re0_0_14

262786
type: LocalParameter
units: 261478
value: 1.66053878316273E-5
name: k1

262762
type: SpeciesReference
stoichiometry: 1.0
species: 261599

262750
type: SpeciesReference
stoichiometry: 1.0
species: 261538

262738
type: SpeciesReference
stoichiometry: 1.0
species: 261684

262798
type: Reaction
kinetic law: 262846
product: 262834
product: 262822
reactant: 262810
fast: false
reversible: false
name: re0_0_15

262858
type: LocalParameter
units: 261478
value: 1.5
name: k1

262834
type: SpeciesReference
stoichiometry: 1.0
species: 261538

262822
type: SpeciesReference
stoichiometry: 1.0
species: 261684

262810
type: SpeciesReference
stoichiometry: 1.0
species: 261599

261780
type: Reaction
kinetic law: 261829
product: 261817
product: 261805
reactant: 261792
fast: false
reversible: false
name: re0_0_1

261842
type: LocalParameter
units: 261478
value: 1000.0
name: k1

261817
type: SpeciesReference
stoichiometry: 1.0
species: 261660

261805
type: SpeciesReference
stoichiometry: 1.0
species: 261660

261792
type: SpeciesReference
stoichiometry: 1.0
species: 261672

262942
type: Reaction
kinetic law: 262991
product: 262978
product: 262966
reactant: 262954
fast: false
reversible: false
name: re0_0_17

263003
type: LocalParameter
units: 261478
value: 90.0
name: k1

262978
type: SpeciesReference
stoichiometry: 1.0
species: 261538

262966
type: SpeciesReference
stoichiometry: 1.0
species: 261696

262954
type: SpeciesReference
stoichiometry: 1.0
species: 261611

263233
type: Reaction
kinetic law: 263282
product: 263270
product: 263258
reactant: 263246
fast: false
reversible: false
name: re0_0_21

263294
type: LocalParameter
units: 261478
value: 100.0
name: k1

263270
type: SpeciesReference
stoichiometry: 1.0
species: 261599

263258
type: SpeciesReference
stoichiometry: 1.0
species: 261599

263246
type: SpeciesReference
stoichiometry: 1.0
species: 261562

262508
type: Reaction
kinetic law: 262557
product: 262545
product: 262533
reactant: 262520
fast: false
reversible: false
name: re0_0_11

262569
type: LocalParameter
units: 261478
value: 0.02
name: k1

262545
type: SpeciesReference
stoichiometry: 1.0
species: 261574

262533
type: SpeciesReference
stoichiometry: 1.0
species: 261623

262520
type: SpeciesReference
stoichiometry: 1.0
species: 261635

262654
type: Reaction
kinetic law: 262702
product: 262690
product: 262678
reactant: 262666
fast: false
reversible: false
name: re0_0_13

262714
type: LocalParameter
units: 261478
value: 0.05
name: k1

262690
type: SpeciesReference
stoichiometry: 1.0
species: 261684

262678
type: SpeciesReference
stoichiometry: 1.0
species: 261684

262666
type: SpeciesReference
stoichiometry: 1.0
species: 261696

262363
type: Reaction
kinetic law: 262412
product: 262400
product: 262388
reactant: 262375
fast: false
reversible: false
name: re0_0_9

262424
type: LocalParameter
units: 261478
value: 100.0
name: k1

262400
type: SpeciesReference
stoichiometry: 1.0
species: 261574

262388
type: SpeciesReference
stoichiometry: 1.0
species: 261574

262375
type: SpeciesReference
stoichiometry: 1.0
species: 261550

261999
type: Reaction
kinetic law: 262048
product: 262036
reactant: 262023
reactant: 262011
fast: false
reversible: false
name: re0_0_4

262061
type: LocalParameter
units: 261478
value: 1.66053878316273E-5
name: k1

262036
type: SpeciesReference
stoichiometry: 1.0
species: 261586

262023
type: SpeciesReference
stoichiometry: 1.0
species: 261672

262011
type: SpeciesReference
stoichiometry: 1.0
species: 261538