MODEL1201140000
type: SBMLModel
parameter: 183570
rule: 184198
parameter: 183933
parameter: 183993
substance units: 163161
parameter: 183752
parameter: 183716
parameter: 183740
parameter: 183545
parameter: 183776
parameter: 183679
parameter: 183958
parameter: 183691
rule: 184210
rule: 184162
rule: 184114
parameter: 183557
parameter: 183836
compartment: 183533
parameter: 183788
parameter: 183764
volume units: 122997
rule: 184222
rule: 184174
parameter: 184029
rule: 184186
name: Gall1999_CalciumBursting_BetaCellModel_C
parameter: 183620
parameter: 183873
parameter: 184017
parameter: 183728
parameter: 183981
parameter: 183897
parameter: 183594
parameter: 184006
parameter: 183632
parameter: 183800
parameter: 183582
parameter: 183861
curated: false
parameter: 183848
parameter: 183824
parameter: 183885
parameter: 184041
time units: 152087
length unit: 802859
rule: 184127
parameter: 184065
parameter: 183655
parameter: 184077
rule: 184139
area units: 802883
parameter: 183970
parameter: 184053
parameter: 183812
parameter: 183704
rule: 184102
parameter: 183606
is described by: http://identifiers.org/pubmed/10388739
parameter: 183667
parameter: 183643
notes: This a model from the article: Effect of Na/Ca exchange on plateau fraction and [Ca]i in models for bursting in pancreatic beta-cells. Gall D, Susa I. Biophys J. 1999 Jul;77(1):45-53. 10388739 , Abstract: In the presence of an insulinotropic glucose concentration, beta-cells, in intact pancreatic islets, exhibit periodic bursting electrical activity consisting of an alternation of active and silent phases. The fraction of time spent in the active phase over a period is called the plateau fraction and is correlated with the rate of insulin release. However, the mechanisms that regulate the plateau fraction remain unclear. In this paper we investigate the possible role of the plasma membrane Na+/Ca2+ exchange of the beta-cell in controlling the plateau fraction. We have extended different single-cell models to incorporate this Ca2+-activated electrogenic Ca2+ transporter. We find that the Na+/Ca2+ exchange can provide a physiological mechanism to increase the plateau fraction as the glucose concentration is raised. In addition, we show theoretically that the Na+/Ca2+ exchanger is a key regulator of the cytoplasmic calcium concentration in clusters of heterogeneous cells with gap-junctional electrical coupling. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Gall and Susa(1999)_Model C The original CellML model was created by: Catherine Lloyd c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable,…
parameter: 183922
rule: 184150
rule: 184090
parameter: 183909
parameter: 183945

183570
type: Parameter
constant: true
value: 5310.0
name: Cm

183933
type: Parameter
constant: false
value: NaN
name: V_Na_Ca

183993
type: Parameter
constant: true
value: 10.0
name: Na_i

183752
type: Parameter
constant: true
value: NaN
name: time

183716
type: Parameter
constant: true
value: 6.0
name: c

183740
type: Parameter
constant: true
value: NaN
name: V

183545
type: Parameter
constant: true
value: NaN
name: time

183776
type: Parameter
constant: true
value: 25.0
name: V_Ca

183679
type: Parameter
constant: true
value: 5.6
name: S_n

183958
type: Parameter
constant: true
value: 5.0
name: nH

183691
type: Parameter
constant: true
value: 65.0
name: a

183557
type: Parameter
constant: false
value: -76.0
name: V

183836
type: Parameter
constant: true
value: NaN
name: V

183533
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0

183788
type: Parameter
constant: true
value: 1000.0
name: g_Ca

183764
type: Parameter
constant: false
value: NaN
name: i_Ca

184029
type: Parameter
constant: true
value: 0.001
name: f

183620
type: Parameter
constant: false
value: 0.1
name: n

183873
type: Parameter
constant: true
value: 30000.0
name: g_K_Ca

184017
type: Parameter
constant: false
value: 0.7
name: Ca_ret

183728
type: Parameter
constant: true
value: -75.0
name: V_

183981
type: Parameter
constant: true
value: 2600.0
name: Ca_o

183897
type: Parameter
constant: false
value: NaN
name: i_Na_Ca

183594
type: Parameter
constant: true
value: -75.0
name: V_K

184006
type: Parameter
constant: true
value: 140.0
name: Na_o

183632
type: Parameter
constant: false
value: NaN
name: n_infinity

183800
type: Parameter
constant: false
value: NaN
name: m_infinity

183582
type: Parameter
constant: false
value: NaN
name: i_K

183861
type: Parameter
constant: false
value: NaN
name: i_K_Ca

183848
type: Parameter
constant: true
value: NaN
name: time

183824
type: Parameter
constant: true
value: 12.0
name: S_m

183885
type: Parameter
constant: true
value: 70.0
name: K_d

184041
type: Parameter
constant: true
value: 0.64
name: k_Ca

184065
type: Parameter
constant: true
value: 0.2
name: k_pump

183655
type: Parameter
constant: false
value: NaN
name: tau_n

184077
type: Parameter
constant: true
value: 6.0E-5
name: alpha

183970
type: Parameter
constant: false
value: 0.52
name: Ca_i

184053
type: Parameter
constant: true
value: 6.0E-4
name: k_rel

183812
type: Parameter
constant: true
value: -20.0
name: V_m

183704
type: Parameter
constant: true
value: 20.0
name: b

183606
type: Parameter
constant: true
value: 2700.0
name: g_K

183667
type: Parameter
constant: true
value: -15.0
name: V_n

183643
type: Parameter
constant: true
value: 0.85
name: lamda

183922
type: Parameter
constant: true
value: 1.5
name: K_1_2

183909
type: Parameter
constant: true
value: 1000.0
name: g_Na_Ca

183945
type: Parameter
constant: true
value: 26.54
name: RT_F