MODEL1201070001
type: SBMLModel
created:
  W3 CDTF: Sat Jan 07 18:17:45 GMT 2012
parameter: 259460
rule: 259451
length unit: 802859
parameter: 259468
parameter: 259514
parameter: 259472
parameter: 259507
time units: 152087
parameter: 259519
parameter: 259491
parameter: 259499
rule: 259447
parameter: 259494
parameter: 259520
parameter: 259464
parameter: 259510
creator:
  ORG:
    orgname: The University of Auckland,The Bioengineering Institute
  n:
    given: Catherine
    family: Lloyd
rule: 259454
parameter: 259496
parameter: 259476
parameter: 259522
rule: 259442
name: Gall1999_CalciumBursting_BetaCellModel_B
parameter: 259466
parameter: 259503
substance units: 163161
parameter: 259470
rule: 259441
parameter: 259478
parameter: 259486
modified:
  W3 CDTF: Sat Jan 07 18:20:20 GMT 2012
parameter: 259515
parameter: 259506
parameter: 259482
parameter: 259490
parameter: 259498
parameter: 259508
parameter: 259488
parameter: 259484
parameter: 259492
rule: 259458
rule: 259456
notes: This a model from the article: Effect of Na/Ca exchange on plateau fraction and [Ca]i in models for bursting in pancreatic beta-cells. Gall D, Susa I. Biophys J. 1999 Jul;77(1):45-53. 10388739 , Abstract: In the presence of an insulinotropic glucose concentration, beta-cells, in intact pancreatic islets, exhibit periodic bursting electrical activity consisting of an alternation of active and silent phases. The fraction of time spent in the active phase over a period is called the plateau fraction and is correlated with the rate of insulin release. However, the mechanisms that regulate the plateau fraction remain unclear. In this paper we investigate the possible role of the plasma membrane Na+/Ca2+ exchange of the beta-cell in controlling the plateau fraction. We have extended different single-cell models to incorporate this Ca2+-activated electrogenic Ca2+ transporter. We find that the Na+/Ca2+ exchange can provide a physiological mechanism to increase the plateau fraction as the glucose concentration is raised. In addition, we show theoretically that the Na+/Ca2+ exchanger is a key regulator of the cytoplasmic calcium concentration in clusters of heterogeneous cells with gap-junctional electrical coupling. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Gall and Susa(1999)_Model B The original CellML model was created by: Catherine Lloyd c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it …
curated: false
rule: 259448
parameter: 259462
rule: 259446
parameter: 259474
rule: 259445
parameter: 259511
parameter: 259502
modified:
  W3 CDTF: Sat Jan 07 18:20:20 GMT 2012
parameter: 259523
rule: 259452
area units: 802883
parameter: 259467
is described by: http://identifiers.org/pubmed/10388739
rule: 259450
parameter: 259504
parameter: 259480
parameter: 259471
parameter: 259479
parameter: 259487
parameter: 259516
parameter: 259483
volume units: 122997
parameter: 259518
parameter: 259461
compartment: 259437
rule: 259455
creator:
  ORG:
    orgname: The University of Auckland,The Bioengineering Institute
  n:
    given: Catherine
    family: Lloyd
creator:
  ORG:
    orgname: The University of Auckland,The Bioengineering Institute
  n:
    given: Catherine
    family: Lloyd
parameter: 259463
parameter: 259500
parameter: 259495
parameter: 259475
parameter: 259512
rule: 259443

259460
type: Parameter
constant: true
value: NaN
name: time

259468
type: Parameter
constant: false
value: NaN
name: n_infinity

259514
type: Parameter
constant: true
value: 10.0
name: Na_i

259472
type: Parameter
constant: true
value: -16.0
name: V_n

259507
type: Parameter
constant: false
value: NaN
name: V_Na_Ca

259519
type: Parameter
constant: true
value: 0.64
name: k_Ca

259491
type: Parameter
constant: false
value: 0.1
name: s

259499
type: Parameter
constant: false
value: NaN
name: S_V_R_s

259494
type: Parameter
constant: true
value: 12000.0
name: tau_s

259520
type: Parameter
constant: true
value: 6.0E-4
name: k_rel

259464
type: Parameter
constant: true
value: -75.0
name: V_K

259510
type: Parameter
constant: true
value: 5.0
name: nH

259496
type: Parameter
constant: true
value: 10.0
name: S_s

259476
type: Parameter
constant: true
value: NaN
name: time

259522
type: Parameter
constant: true
value: 0.2
name: k_pump

259466
type: Parameter
constant: true
value: 2700.0
name: g_K

259503
type: Parameter
constant: false
value: NaN
name: i_Na_Ca

259470
type: Parameter
constant: true
value: 1.0
name: lamda

259478
type: Parameter
constant: false
value: NaN
name: i_Ca

259486
type: Parameter
constant: true
value: NaN
name: V

259515
type: Parameter
constant: true
value: 140.0
name: Na_o

259506
type: Parameter
constant: true
value: 1.5
name: K_1_2

259482
type: Parameter
constant: false
units: dimensionless
value: NaN
name: m_infinity

259490
type: Parameter
constant: true
value: 200.0
name: g_s

259498
type: Parameter
constant: true
value: 0.58
name: R_s

259508
type: Parameter
constant: true
value: 26.54
name: RT_F

259488
type: Parameter
constant: false
value: NaN
name: i_slow

259484
type: Parameter
constant: true
value: 12.0
name: S_m

259492
type: Parameter
constant: false
value: NaN
name: s_infinity

259462
type: Parameter
constant: true
value: 5310.0
name: Cm

259474
type: Parameter
constant: true
value: 5.6
name: S_n

259511
type: Parameter
constant: false
value: 0.52
name: Ca_i

259502
type: Parameter
constant: true
value: NaN
name: time

259523
type: Parameter
constant: true
value: 6.0E-5
name: alpha

259467
type: Parameter
constant: false
value: 0.1
name: n

259504
type: Parameter
constant: true
value: 350.0
name: g_Na_Ca

259480
type: Parameter
constant: true
value: 1000.0
name: g_Ca

259471
type: Parameter
constant: true
value: 20.0
name: tau_n

259479
type: Parameter
constant: true
value: 25.0
name: V_Ca

259487
type: Parameter
constant: true
value: NaN
name: time

259516
type: Parameter
constant: false
value: 0.7
name: Ca_ret

259483
type: Parameter
constant: true
value: -20.0
name: V_m

259518
type: Parameter
constant: true
value: 0.02
name: f

259461
type: Parameter
constant: false
value: -76.0
name: V

259437
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0

259463
type: Parameter
constant: false
value: NaN
name: i_K

259500
type: Parameter
constant: true
value: NaN
name: V

259495
type: Parameter
constant: true
value: -52.0
name: V_s

259475
type: Parameter
constant: true
value: NaN
name: V

259512
type: Parameter
constant: true
value: 2600.0
name: Ca_o

W3 CDTF: Sat Jan 07 18:20:20 GMT 2012