MODEL1172425728
type: SBMLModel
rule: 686159
parameter: 686247
parameter: 686365
parameter: 686286
units def: 151859
parameter: 686232
rule: 686125
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parameter: 686353
rule: 686137
rule: 686164
units def: 151919
rule: 686129
rule: 686130
parameter: 686307
parameter: 686231
rule: 686122
units def: 152087
rule: 686114
rule: 686184
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parameter: 686235
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rule: 686168
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parameter: 686352
parameter: 686253
rule: 686134
parameter: 686322
rule: 686126
parameter: 686356
rule: 686118
parameter: 686223
parameter: 686374
parameter: 686241
rule: 686190
parameter: 686383
parameter: 686250
parameter: 686284
parameter: 686277
parameter: 686346
parameter: 686371
parameter: 686385
parameter: 686310
parameter: 686252
length unit: 802859
area units: 802883
is described by: 978-3-540-69389-5 14
parameter: 686265
parameter: 686268
parameter: 686305
parameter: 686274
rule: 686198
parameter: 686373
units def: 151967
rule: 686210
parameter: 686370
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parameter: 686350
parameter: 686258
parameter: 686276
parameter: 686273
parameter: 686329
parameter: 686298
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parameter: 686379
compartment: 686108
parameter: 686340
parameter: 686261
parameter: 686361
parameter: 686344
rule: 686211
parameter: 686228
notes: This a model from the article: Simulating Complex Calcium-Calcineurin Signaling Network Jiangjun Cui and Jaap A. Kaandorp Lecture Notes in Computer Science 2008; Volume 5103/2008;110-119 doi:10.1007/978-3-540-69389-5_14 , Abstract: Understanding of processes in which calcium signaling is involved is of fundamental importance in systems biology and has many applications in medicine. In this paper we have studied the particular case of the complex calcium-calcineurin-MCIP-NFAT signaling network in cardiac myocytes, the understanding of which is critical for treatment of pathologic hypertrophy and heart failure. By including some most recent experimental findings, we constructed a computational model totally based on biochemical principles. The model can correctly predict the mutant (MCIP1− / −) behavior under different stress such as PO (pressure overload) and CaN* (activated calcineurin) overexpression. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Jiangjun Cui and Jaap A. Kaandorp, (2008) -version02 The original CellML model was created by: Lloyd, Catherine, May c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Sn…
parameter: 686364
parameter: 686367
rule: 686161
parameter: 686234

686247
type: Parameter
constant: false
units: 151883
value: 0.0798
name: MCIPpp

151883
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151907
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151895
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kind: MOLE

686365
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value: 0.05
name: k32

151967
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151979
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kind: SECOND

686286
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name: v11a

151919
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151955
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151943
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151871
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686232
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value: 0.17
name: GSK3betac

686353
type: Parameter
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151991
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152027
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152015
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152003
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686307
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686231
type: Parameter
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152087
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152099
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686235
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value: 0.91
name: CaNc

686352
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686253
type: Parameter
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name: P1433

686322
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name: k3

686356
type: Parameter
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name: k26

686223
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value: 0.012
name: BMK1

686374
type: Parameter
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units: 151991
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name: k38

686241
type: Parameter
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value: 25.2
name: CaM

686383
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name: t_half

686250
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value: 0.283
name: Comp2

686284
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686277
type: Parameter
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686346
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name: k19

686371
type: Parameter
constant: true
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value: 0.1
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686385
type: Parameter
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units: 151883
value: 0.2
name: Ca

686310
type: Parameter
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value: NaN
name: v16b

686252
type: Parameter
constant: false
units: 151883
value: 0.014
name: Comp3

686265
type: Parameter
constant: false
units: 151883
value: 8.46E-5
name: NFATn_GSK3betan

686268
type: Parameter
constant: false
units: 151919
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name: v2

686305
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value: NaN
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686274
type: Parameter
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686373
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constant: true
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value: 0.2
name: k37

686370
type: Parameter
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value: 0.15
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686350
type: Parameter
constant: true
units: 151967
value: 0.15
name: k22

686258
type: Parameter
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value: 0.0011
name: MCIPp_GSK3betac

686276
type: Parameter
constant: false
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686273
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686329
type: Parameter
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686298
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name: v14

686379
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686108
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686340
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name: k15

686261
type: Parameter
constant: false
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value: 8.15E-5
name: NFATpc_CaNc_star

686361
type: Parameter
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value: 0.4
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686344
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686228
type: Parameter
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name: NFATn

686364
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686367
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686234
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686299
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686368
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686301
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686355
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686314
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686332
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686256
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value: 1.07E-4
name: MCIPp_CaNc_star

686271
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686287
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constant: false
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686296
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686377
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constant: true
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686325
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name: k5

686338
type: Parameter
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686226
type: Parameter
constant: false
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value: 2.0E-5
name: NFATc

686295
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constant: false
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686317
type: Parameter
constant: false
units: 151919
value: NaN
name: v19

686244
type: Parameter
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value: 2.15E-4
name: MCIP

686313
type: Parameter
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686382
type: Parameter
constant: true
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name: k43

686270
type: Parameter
constant: false
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686362
type: Parameter
constant: true
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value: 0.1
name: k30

686283
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constant: false
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name: v10b

686349
type: Parameter
constant: true
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value: 0.15
name: k21

686279
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value: NaN
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152039
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152075
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152063
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152051
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686316
type: Parameter
constant: false
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value: NaN
name: v18

686229
type: Parameter
constant: false
units: 151883
value: 0.00494
name: NFATpc

686290
type: Parameter
constant: false
units: 151919
value: NaN
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686267
type: Parameter
constant: false
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value: NaN
name: v1

686337
type: Parameter
constant: true
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name: k13

686304
type: Parameter
constant: false
units: 151919
value: NaN
name: v15a

686302
type: Parameter
constant: false
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value: NaN
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686320
type: Parameter
constant: true
value: 100.0
name: k2

686323
type: Parameter
constant: true
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value: 0.072
name: k4

686293
type: Parameter
constant: false
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value: NaN
name: v13

686328
type: Parameter
constant: true
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value: 5.0
name: k7

686311
type: Parameter
constant: false
units: 151919
value: NaN
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686380
type: Parameter
constant: true
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value: 0.03
name: k42

686343
type: Parameter
constant: true
units: 151967
value: 0.1
name: k17

686281
type: Parameter
constant: false
units: 151919
value: NaN
name: v10a

686326
type: Parameter
constant: true
units: 151967
value: 0.0567
name: k6

686347
type: Parameter
constant: true
units: 151967
value: 0.1
name: k20

686331
type: Parameter
constant: true
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value: 0.5
name: k9

686335
type: Parameter
constant: true
units: 151967
value: 0.1
name: k12

686292
type: Parameter
constant: false
units: 151919
value: NaN
name: v12b

686249
type: Parameter
constant: false
units: 151883
value: 0.00521
name: Comp1

686238
type: Parameter
constant: false
units: 151883
value: 0.0568
name: CaNn_star

686334
type: Parameter
constant: true
units: 151967
value: 0.1
name: k11

686289
type: Parameter
constant: false
units: 151919
value: NaN
name: v12

686359
type: Parameter
constant: true
units: 151967
value: 0.1
name: k28

686308
type: Parameter
constant: false
units: 151919
value: NaN
name: v16a

686240
type: Parameter
constant: false
units: 151883
value: 0.0057
name: CaNn

686237
type: Parameter
constant: false
units: 151883
value: 0.0275
name: CaNc_star

686341
type: Parameter
constant: true
units: 151991
value: 0.1
name: k16

686262
type: Parameter
constant: false
units: 151883
value: 1.36E-6
name: NFATc_GSK3betac

686280
type: Parameter
constant: false
units: 151919
value: NaN
name: v10

686255
type: Parameter
constant: false
units: 151883
value: 2.14E-5
name: MCIP_BMK1

686358
type: Parameter
constant: true
units: 151991
value: 0.4
name: k27

686259
type: Parameter
constant: false
units: 151883
value: 0.0011
name: MCIPpp_CaNc_star

686225
type: Parameter
constant: false
units: 151883
value: 3.33E-4
name: MRNA

686319
type: Parameter
constant: true
value: 5.0
name: k1

686376
type: Parameter
constant: true
units: 151967
value: 0.1
name: k39

686243
type: Parameter
constant: false
units: 151883
value: 7.88E-7
name: CaMCa

686246
type: Parameter
constant: false
units: 151883
value: 0.00776
name: MCIPp

686264
type: Parameter
constant: false
units: 151883
value: 2.27E-6
name: NFATpn_CaNn_star