MODEL1112260002
type: SBMLModel
reaction: 131411
reaction: 133084
reaction: 132137
reaction: 127536
reaction: 130464
reaction: 124122
reaction: 127902
reaction: 131338
reaction: 125512
reaction: 126953
species: 123590
reaction: 129014
reaction: 129232
reaction: 124487
reaction: 131047
reaction: 124909
rule: 123809
reaction: 130390
reaction: 128435
reaction: 125572
reaction: 124306
species: 123797
compartment: 123081
rule: 123821
reaction: 130245
reaction: 128581
reaction: 126373
species: 123445
species: 123748
reaction: 129595
reaction: 128508
compartment: 123093
species: 123518
species: 123433
reaction: 125270
reaction: 132065
species: 123712
reaction: 125633
reaction: 128942
reaction: 132648
species: 123203
volume units: 122997
species: 123506
reaction: 127026
compartment: 123117
species: 123784
reaction: 127755
reaction: 129523
species: 123530
species: 123349
rule: 123881
species: 123385
species: 123313
reaction: 132576
species: 123554
reaction: 124001
reaction: 126227
reaction: 131628
reaction: 128653
species: 123409
reaction: 127389
species: 123373
species: 123301
reaction: 131700
species: 123542
reaction: 131192
reaction: 129739
reaction: 126155
reaction: 127683
reaction: 132769
reaction: 130318
units def: 122997
reaction: 129378
species: 123228
species: 123277
reaction: 132431
length unit: 802859
species: 123216
reaction: 126010

131411
type: Reaction
kinetic law: 131459
modifier: 131447
product: 131435
reactant: 131423
fast: false
reversible: false
name: degradation of cytoplasm_Foxo1_Pa1_Pd1_pUb1

131471
type: LocalParameter
value: 1.0E-4

123797
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1000.0
in compartment: 123093

123093
type: Compartment
constant: true
size: 1.65E-11
spatial dimensions: 3.0

131435
type: SpeciesReference
stoichiometry: 1.0
species: 123141

123141
type: Species
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123093

131423
type: SpeciesReference
stoichiometry: 1.0
species: 123409

123409
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123093

133084
type: Reaction
kinetic law: 133120
product: 133108
reactant: 133096
fast: false
reversible: false
name: cyto degr of sod2 RNA

133132
type: LocalParameter
value: 5.622

133108
type: SpeciesReference
stoichiometry: 1.0
species: 123129

123129
type: Species
constant: false
boundary condition: true
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123093

133096
type: SpeciesReference
stoichiometry: 1.0
species: 123614

123614
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123093

132137
type: Reaction
kinetic law: 132185
modifier: 132173
product: 132161
reactant: 132149
fast: false
reversible: false
name: transcription of sod2 by dnabound_Foxo1_Pa1_Pd0_pUb0

132197
type: LocalParameter
value: 0.3

123325
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123117

123117
type: Compartment
constant: true
size: 1.0E-13
spatial dimensions: 3.0

132161
type: SpeciesReference
stoichiometry: 1.0
species: 123602

123602
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123105

123105
type: Compartment
constant: true
size: 5.0E-13
spatial dimensions: 3.0

132149
type: SpeciesReference
stoichiometry: 1.0
species: 123129

127536
type: Reaction
kinetic law: 127585
modifier: 127573
product: 127561
reactant: 127548
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_pUb1 to nucleus_Foxo1_Pa1_Pd1_pUb1 by SGK

127597
type: LocalParameter
value: 5.0E-5

123662
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123093

127561
type: SpeciesReference
stoichiometry: 1.0
species: 123421

123421
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123105

127548
type: SpeciesReference
stoichiometry: 1.0
species: 123277

123277
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123105

130464
type: Reaction
kinetic law: 130512
modifier: 130500
product: 130488
reactant: 130476
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_pUb0 to dnabound_Foxo1_Pa0_Pd0_pUb1 by SCF

130524
type: LocalParameter
value: 1.0E-6

123784
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1000.0
in compartment: 123093

130488
type: SpeciesReference
stoichiometry: 1.0
species: 123216

123216
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123117

130476
type: SpeciesReference
stoichiometry: 1.0
species: 123177

123177
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123117

124122
type: Reaction
kinetic law: 124159
product: 124147
reactant: 124135
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd0_pUb0 to dnabound_Foxo1_Pa0_Pd0_pUb0

124171
type: LocalParameter
value: 0.25

124147
type: SpeciesReference
stoichiometry: 1.0
species: 123177

124135
type: SpeciesReference
stoichiometry: 1.0
species: 123165

123165
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123105

127902
type: Reaction
kinetic law: 127953
modifier: 127940
product: 127927
reactant: 127914
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_pUb1 by PP2A

127966
type: LocalParameter
value: 5.0E-5

123724
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 10000.0
in compartment: 123093

127927
type: SpeciesReference
stoichiometry: 1.0
species: 123190

123190
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123093

127914
type: SpeciesReference
stoichiometry: 1.0
species: 123337

123337
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123093

131338
type: Reaction
kinetic law: 131387
modifier: 131375
product: 131362
reactant: 131350
fast: false
reversible: false
name: degradation of cytoplasm_Foxo1_Pa1_Pd0_pUb1

131399
type: LocalParameter
value: 1.0E-4

131362
type: SpeciesReference
stoichiometry: 1.0
species: 123141

131350
type: SpeciesReference
stoichiometry: 1.0
species: 123337

125512
type: Reaction
kinetic law: 125548
product: 125536
reactant: 125524
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_pUb0

125560
type: LocalParameter
value: 5.5

125536
type: SpeciesReference
stoichiometry: 1.0
species: 123373

123373
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123093

125524
type: SpeciesReference
stoichiometry: 1.0
species: 123385

123385
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123105

126953
type: Reaction
kinetic law: 127002
modifier: 126990
product: 126978
reactant: 126965
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_pUb0 to dnabound_Foxo1_Pa1_Pd0_pUb0 by SGK

127014
type: LocalParameter
value: 5.0E-5

126978
type: SpeciesReference
stoichiometry: 1.0
species: 123325

126965
type: SpeciesReference
stoichiometry: 1.0
species: 123177

123590
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123093

129014
type: Reaction
kinetic law: 129063
modifier: 129050
product: 129038
reactant: 129026
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_pUb0 by PP2A

129075
type: LocalParameter
value: 5.0E-5

129038
type: SpeciesReference
stoichiometry: 1.0
species: 123153

123153
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1000.0
in compartment: 123093

129026
type: SpeciesReference
stoichiometry: 1.0
species: 123228

123228
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123093

129232
type: Reaction
kinetic law: 129281
modifier: 129269
product: 129257
reactant: 129245
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_pUb1 by PP2A

129293
type: LocalParameter
value: 5.0E-5

129257
type: SpeciesReference
stoichiometry: 1.0
species: 123190

129245
type: SpeciesReference
stoichiometry: 1.0
species: 123265

123265
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123093

124487
type: Reaction
kinetic law: 124523
product: 124511
reactant: 124499
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa0_Pd1_pUb0 to nucleus_Foxo1_Pa0_Pd1_pUb0

124535
type: LocalParameter
value: 0.0909090909091

124511
type: SpeciesReference
stoichiometry: 1.0
species: 123241

123241
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123105

124499
type: SpeciesReference
stoichiometry: 1.0
species: 123228

131047
type: Reaction
kinetic law: 131095
modifier: 131083
product: 131071
reactant: 131059
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd1_pUb0 to nucleus_Foxo1_Pa1_Pd1_pUb1 by SCF

131107
type: LocalParameter
value: 6.6E-5

131071
type: SpeciesReference
stoichiometry: 1.0
species: 123421

131059
type: SpeciesReference
stoichiometry: 1.0
species: 123385

124909
type: Reaction
kinetic law: 124945
product: 124933
reactant: 124921
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa0_Pd1_pUb1 to nucleus_Foxo1_Pa0_Pd1_pUb1

124957
type: LocalParameter
value: 0.125

124933
type: SpeciesReference
stoichiometry: 1.0
species: 123277

124921
type: SpeciesReference
stoichiometry: 1.0
species: 123289

123289
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123117

130390
type: Reaction
kinetic law: 130439
modifier: 130426
product: 130414
reactant: 130402
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd0_pUb0 to nucleus_Foxo1_Pa0_Pd0_pUb1 by SCF

130452
type: LocalParameter
value: 1.0E-6

130414
type: SpeciesReference
stoichiometry: 1.0
species: 123203

123203
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123105

130402
type: SpeciesReference
stoichiometry: 1.0
species: 123165

128435
type: Reaction
kinetic law: 128483
modifier: 128471
product: 128459
reactant: 128447
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd1_pUb1 to nucleus_Foxo1_Pa0_Pd1_pUb1 by PP2A

128495
type: LocalParameter
value: 5.0E-5

128459
type: SpeciesReference
stoichiometry: 1.0
species: 123277

128447
type: SpeciesReference
stoichiometry: 1.0
species: 123421

125572
type: Reaction
kinetic law: 125608
product: 125596
reactant: 125584
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd1_pUb0 to dnabound_Foxo1_Pa1_Pd1_pUb0

125620
type: LocalParameter
value: 0.125

125596
type: SpeciesReference
stoichiometry: 1.0
species: 123397

123397
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123117

125584
type: SpeciesReference
stoichiometry: 1.0
species: 123385

124306
type: Reaction
kinetic law: 124342
product: 124330
reactant: 124318
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_pUb1

124354
type: LocalParameter
value: 0.055

124330
type: SpeciesReference
stoichiometry: 1.0
species: 123190

124318
type: SpeciesReference
stoichiometry: 1.0
species: 123203

123081
type: Compartment
constant: true
size: 6.4E-14
spatial dimensions: 3.0

130245
type: Reaction
kinetic law: 130294
modifier: 130282
product: 130270
reactant: 130258
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd1_pUb1 to dnabound_Foxo1_Pa1_Pd0_pUb1 by PP2A

130306
type: LocalParameter
value: 5.0E-5

130270
type: SpeciesReference
stoichiometry: 1.0
species: 123361

123361
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123117

130258
type: SpeciesReference
stoichiometry: 1.0
species: 123433

123433
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123117

128581
type: Reaction
kinetic law: 128629
modifier: 128617
product: 128605
reactant: 128593
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_pUb0 by IKKb

128641
type: LocalParameter
value: 5.0E-5

123699
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 100000.0
in compartment: 123093

128605
type: SpeciesReference
stoichiometry: 1.0
species: 123228

128593
type: SpeciesReference
stoichiometry: 1.0
species: 123153

126373
type: Reaction
kinetic law: 126421
modifier: 126409
product: 126397
reactant: 126385
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_pUb0 by Akt

126433
type: LocalParameter
value: 5.0E-5

123650
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 10.0
in compartment: 123093

126397
type: SpeciesReference
stoichiometry: 1.0
species: 123373

126385
type: SpeciesReference
stoichiometry: 1.0
species: 123228

123445
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123069

123069
type: Compartment
constant: true
size: 8.3E-12
spatial dimensions: 3.0

123748
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1000.0
in compartment: 123093

129595
type: Reaction
kinetic law: 129643
modifier: 129631
product: 129619
reactant: 129607
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd0_pUb0 to dnabound_Foxo1_Pa1_Pd1_pUb0 by IKKb

129655
type: LocalParameter
value: 5.0E-5

129619
type: SpeciesReference
stoichiometry: 1.0
species: 123397

129607
type: SpeciesReference
stoichiometry: 1.0
species: 123325

128508
type: Reaction
kinetic law: 128556
modifier: 128544
product: 128532
reactant: 128520
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd1_pUb1 to dnabound_Foxo1_Pa0_Pd1_pUb1 by PP2A

128568
type: LocalParameter
value: 5.0E-5

128532
type: SpeciesReference
stoichiometry: 1.0
species: 123289

128520
type: SpeciesReference
stoichiometry: 1.0
species: 123433

123518
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123069

125270
type: Reaction
kinetic law: 125306
product: 125294
reactant: 125282
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_pUb1

125319
type: LocalParameter
value: 0.55

125294
type: SpeciesReference
stoichiometry: 1.0
species: 123337

125282
type: SpeciesReference
stoichiometry: 1.0
species: 123349

123349
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123105

132065
type: Reaction
kinetic law: 132113
modifier: 132101
product: 132089
reactant: 132077
fast: false
reversible: false
name: transcription of inr by dnabound_Foxo1_Pa1_Pd0_pUb0

132125
type: LocalParameter
value: 0.3

132089
type: SpeciesReference
stoichiometry: 1.0
species: 123566

123566
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123105

132077
type: SpeciesReference
stoichiometry: 1.0
species: 123129

123712
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123093

125633
type: Reaction
kinetic law: 125670
product: 125658
reactant: 125646
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa1_Pd1_pUb0 to nucleus_Foxo1_Pa1_Pd1_pUb0

125682
type: LocalParameter
value: 0.125

125658
type: SpeciesReference
stoichiometry: 1.0
species: 123385

125646
type: SpeciesReference
stoichiometry: 1.0
species: 123397

128942
type: Reaction
kinetic law: 128990
modifier: 128978
product: 128966
reactant: 128954
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_pUb1 to dnabound_Foxo1_Pa0_Pd1_pUb1 by IKKb

129002
type: LocalParameter
value: 5.0E-5

128966
type: SpeciesReference
stoichiometry: 1.0
species: 123289

128954
type: SpeciesReference
stoichiometry: 1.0
species: 123216

132648
type: Reaction
kinetic law: 132684
product: 132672
reactant: 132660
fast: false
reversible: false
name: basal transcription of inr

132697
type: LocalParameter
value: 3.0

132672
type: SpeciesReference
stoichiometry: 1.0
species: 123566

132660
type: SpeciesReference
stoichiometry: 1.0
species: 123129

123009
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: LITRE

123506
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123069

127026
type: Reaction
kinetic law: 127075
modifier: 127063
product: 127051
reactant: 127038
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_pUb1 by SGK

127087
type: LocalParameter
value: 5.0E-5

127051
type: SpeciesReference
stoichiometry: 1.0
species: 123337

127038
type: SpeciesReference
stoichiometry: 1.0
species: 123190

127755
type: Reaction
kinetic law: 127803
modifier: 127791
product: 127779
reactant: 127767
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd0_pUb0 to nucleus_Foxo1_Pa0_Pd0_pUb0 by PP2A

127815
type: LocalParameter
value: 5.0E-5

127779
type: SpeciesReference
stoichiometry: 1.0
species: 123165

127767
type: SpeciesReference
stoichiometry: 1.0
species: 123313

123313
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123105

129523
type: Reaction
kinetic law: 129571
modifier: 129559
product: 129547
reactant: 129535
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd0_pUb0 to nucleus_Foxo1_Pa1_Pd1_pUb0 by IKKb

129583
type: LocalParameter
value: 5.0E-5

129547
type: SpeciesReference
stoichiometry: 1.0
species: 123385

129535
type: SpeciesReference
stoichiometry: 1.0
species: 123313

123530
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123069

132576
type: Reaction
kinetic law: 132624
modifier: 132612
product: 132600
reactant: 132588
fast: false
reversible: false
name: transcription of sod2 by dnabound_Foxo1_Pa1_Pd1_pUb1

132636
type: LocalParameter
value: 0.3

132600
type: SpeciesReference
stoichiometry: 1.0
species: 123602

132588
type: SpeciesReference
stoichiometry: 1.0
species: 123129

123554
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123069

124001
type: Reaction
kinetic law: 124037
product: 124025
reactant: 124013
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa0_Pd0_pUb0 to nucleus_Foxo1_Pa0_Pd0_pUb0

124049
type: LocalParameter
value: 0.181818181818

124025
type: SpeciesReference
stoichiometry: 1.0
species: 123165

124013
type: SpeciesReference
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species: 123153

126227
type: Reaction
kinetic law: 126277
modifier: 126264
product: 126252
reactant: 126240
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd0_pUb1 to nucleus_Foxo1_Pa1_Pd0_pUb1 by Akt

126289
type: LocalParameter
value: 5.0E-5

126252
type: SpeciesReference
stoichiometry: 1.0
species: 123349

126240
type: SpeciesReference
stoichiometry: 1.0
species: 123203

131628
type: Reaction
kinetic law: 131676
modifier: 131664
product: 131652
reactant: 131640
fast: false
reversible: false
name: transcription of inr by dnabound_Foxo1_Pa0_Pd0_pUb1

131688
type: LocalParameter
value: 0.3

131652
type: SpeciesReference
stoichiometry: 1.0
species: 123566

131640
type: SpeciesReference
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species: 123129

128653
type: Reaction
kinetic law: 128701
modifier: 128689
product: 128677
reactant: 128665
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd0_pUb0 to nucleus_Foxo1_Pa0_Pd1_pUb0 by IKKb

128713
type: LocalParameter
value: 5.0E-5

128677
type: SpeciesReference
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species: 123241

128665
type: SpeciesReference
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species: 123165

127389
type: Reaction
kinetic law: 127439
modifier: 127427
product: 127414
reactant: 127402
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_pUb0 to dnabound_Foxo1_Pa1_Pd1_pUb0 by SGK

127451
type: LocalParameter
value: 5.0E-5

127414
type: SpeciesReference
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species: 123397

127402
type: SpeciesReference
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species: 123253

123253
type: Species
constant: false
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has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123117

123301
type: Species
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boundary condition: false
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initial concentration: NaN
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in compartment: 123093

131700
type: Reaction
kinetic law: 131748
modifier: 131736
product: 131724
reactant: 131712
fast: false
reversible: false
name: transcription of sod2 by dnabound_Foxo1_Pa0_Pd0_pUb1

131760
type: LocalParameter
value: 0.3

131724
type: SpeciesReference
stoichiometry: 1.0
species: 123602

131712
type: SpeciesReference
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species: 123129

123542
type: Species
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initial concentration: NaN
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in compartment: 123069

131192
type: Reaction
kinetic law: 131241
modifier: 131229
product: 131216
reactant: 131204
fast: false
reversible: false
name: degradation of cytoplasm_Foxo1_Pa0_Pd0_pUb1

131253
type: LocalParameter
value: 1.0E-4

131216
type: SpeciesReference
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species: 123141

131204
type: SpeciesReference
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species: 123190

129739
type: Reaction
kinetic law: 129787
modifier: 129775
product: 129763
reactant: 129751
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reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd0_pUb1 to nucleus_Foxo1_Pa1_Pd1_pUb1 by IKKb

129799
type: LocalParameter
value: 5.0E-5

129763
type: SpeciesReference
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species: 123421

129751
type: SpeciesReference
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species: 123349

126155
type: Reaction
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modifier: 126191
product: 126179
reactant: 126167
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_pUb1 by Akt

126215
type: LocalParameter
value: 5.0E-5

126179
type: SpeciesReference
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species: 123337

126167
type: SpeciesReference
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species: 123190

127683
type: Reaction
kinetic law: 127731
modifier: 127719
product: 127707
reactant: 127695
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_pUb0 by PP2A

127743
type: LocalParameter
value: 5.0E-5

127707
type: SpeciesReference
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species: 123153

127695
type: SpeciesReference
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species: 123301

132769
type: Reaction
kinetic law: 132805
product: 132793
reactant: 132781
fast: false
reversible: false
name: cyto degr of inr RNA

132817
type: LocalParameter
value: 5.622

132793
type: SpeciesReference
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species: 123129

132781
type: SpeciesReference
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species: 123578

123578
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
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in compartment: 123093

130318
type: Reaction
kinetic law: 130366
modifier: 130354
product: 130342
reactant: 130330
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_pUb1 by SCF

130378
type: LocalParameter
value: 1.0E-6

130342
type: SpeciesReference
stoichiometry: 1.0
species: 123190

130330
type: SpeciesReference
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species: 123153

129378
type: Reaction
kinetic law: 129426
modifier: 129414
product: 129402
reactant: 129390
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reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_pUb1 to dnabound_Foxo1_Pa0_Pd0_pUb1 by PP2A

129438
type: LocalParameter
value: 5.0E-5

129402
type: SpeciesReference
stoichiometry: 1.0
species: 123216

129390
type: SpeciesReference
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species: 123289

132431
type: Reaction
kinetic law: 132479
modifier: 132467
product: 132455
reactant: 132443
fast: false
reversible: false
name: transcription of sod2 by dnabound_Foxo1_Pa1_Pd1_pUb0

132491
type: LocalParameter
value: 0.3

132455
type: SpeciesReference
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species: 123602

132443
type: SpeciesReference
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species: 123129

126010
type: Reaction
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modifier: 126046
product: 126034
reactant: 126022
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd0_pUb0 to nucleus_Foxo1_Pa1_Pd0_pUb0 by Akt

126070
type: LocalParameter
value: 5.0E-5

126034
type: SpeciesReference
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species: 123313

126022
type: SpeciesReference
stoichiometry: 1.0
species: 123165

127609
type: Reaction
kinetic law: 127658
modifier: 127646
product: 127634
reactant: 127621
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_pUb1 to dnabound_Foxo1_Pa1_Pd1_pUb1 by SGK

127671
type: LocalParameter
value: 5.0E-5

127634
type: SpeciesReference
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species: 123433

127621
type: SpeciesReference
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species: 123289

129450
type: Reaction
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modifier: 129486
product: 129474
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fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_pUb0 by IKKb

129511
type: LocalParameter
value: 5.0E-5

129474
type: SpeciesReference
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species: 123373

129462
type: SpeciesReference
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species: 123301

127317
type: Reaction
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modifier: 127353
product: 127341
reactant: 127329
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_pUb0 to nucleus_Foxo1_Pa1_Pd1_pUb0 by SGK

127377
type: LocalParameter
value: 5.0E-5

127341
type: SpeciesReference
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species: 123385

127329
type: SpeciesReference
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species: 123241

133144
type: Reaction
kinetic law: 133194
modifier: 133181
product: 133169
reactant: 133156
fast: false
reversible: false
name: translation of sod2

133206
type: LocalParameter
value: 1.23

133169
type: SpeciesReference
stoichiometry: 1.0
species: 123626

123626
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
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133156
type: SpeciesReference
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species: 123129

128290
type: Reaction
kinetic law: 128339
modifier: 128327
product: 128315
reactant: 128303
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd1_pUb0 to dnabound_Foxo1_Pa0_Pd1_pUb0 by PP2A

128351
type: LocalParameter
value: 5.0E-5

128315
type: SpeciesReference
stoichiometry: 1.0
species: 123253

128303
type: SpeciesReference
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species: 123397

128725
type: Reaction
kinetic law: 128774
modifier: 128762
product: 128749
reactant: 128737
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_pUb0 to dnabound_Foxo1_Pa0_Pd1_pUb0 by IKKb

128786
type: LocalParameter
value: 5.0E-5

128749
type: SpeciesReference
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species: 123253

128737
type: SpeciesReference
stoichiometry: 1.0
species: 123177

124847
type: Reaction
kinetic law: 124883
product: 124871
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fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd1_pUb1 to dnabound_Foxo1_Pa0_Pd1_pUb1

124896
type: LocalParameter
value: 0.25

124871
type: SpeciesReference
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species: 123289

124859
type: SpeciesReference
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species: 123277

126591
type: Reaction
kinetic law: 126640
modifier: 126628
product: 126616
reactant: 126604
fast: false
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name: conversion of cytoplasm_Foxo1_Pa0_Pd1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_pUb1 by Akt

126652
type: LocalParameter
value: 5.0E-5

126616
type: SpeciesReference
stoichiometry: 1.0
species: 123409

126604
type: SpeciesReference
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species: 123265

126881
type: Reaction
kinetic law: 126929
modifier: 126917
product: 126905
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fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd0_pUb0 to nucleus_Foxo1_Pa1_Pd0_pUb0 by SGK

126941
type: LocalParameter
value: 5.0E-5

126905
type: SpeciesReference
stoichiometry: 1.0
species: 123313

126893
type: SpeciesReference
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species: 123165

125150
type: Reaction
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product: 125174
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fast: false
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name: transport dnabound_Foxo1_Pa1_Pd0_pUb0 to nucleus_Foxo1_Pa1_Pd0_pUb0

125198
type: LocalParameter
value: 0.125

125174
type: SpeciesReference
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species: 123313

125162
type: SpeciesReference
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species: 123325

130682
type: Reaction
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modifier: 130718
product: 130706
reactant: 130694
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_pUb0 to dnabound_Foxo1_Pa0_Pd1_pUb1 by SCF

130742
type: LocalParameter
value: 2.2E-5

130706
type: SpeciesReference
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species: 123289

130694
type: SpeciesReference
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species: 123253

132829
type: Reaction
kinetic law: 132878
modifier: 132865
product: 132853
reactant: 132841
fast: false
reversible: false
name: translation of inr

132890
type: LocalParameter
value: 1.23

132853
type: SpeciesReference
stoichiometry: 1.0
species: 123590

132841
type: SpeciesReference
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species: 123129

125694
type: Reaction
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product: 125719
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fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa1_Pd1_pUb1 to nucleus_Foxo1_Pa1_Pd1_pUb1

125743
type: LocalParameter
value: 0.00909090909091

125719
type: SpeciesReference
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species: 123421

125707
type: SpeciesReference
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species: 123409

131265
type: Reaction
kinetic law: 131313
modifier: 131301
product: 131289
reactant: 131277
fast: false
reversible: false
name: degradation of cytoplasm_Foxo1_Pa0_Pd1_pUb1

131326
type: LocalParameter
value: 1.0E-4

131289
type: SpeciesReference
stoichiometry: 1.0
species: 123141

131277
type: SpeciesReference
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species: 123265

124667
type: Reaction
kinetic law: 124703
product: 124691
reactant: 124679
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa0_Pd1_pUb0 to nucleus_Foxo1_Pa0_Pd1_pUb0

124715
type: LocalParameter
value: 0.125

124691
type: SpeciesReference
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species: 123241

124679
type: SpeciesReference
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species: 123253

132962
type: Reaction
kinetic law: 132999
product: 132987
reactant: 132975
fast: false
reversible: false
name: basal transcription of sod2

133011
type: LocalParameter
value: 3.0

132987
type: SpeciesReference
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species: 123602

132975
type: SpeciesReference
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species: 123129

127827
type: Reaction
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name: conversion of dnabound_Foxo1_Pa1_Pd0_pUb0 to dnabound_Foxo1_Pa0_Pd0_pUb0 by PP2A

127889
type: LocalParameter
value: 5.0E-5

127852
type: SpeciesReference
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species: 123177

127839
type: SpeciesReference
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species: 123325

124969
type: Reaction
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product: 124993
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fast: false
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name: transport cytoplasm_Foxo1_Pa1_Pd0_pUb0 to nucleus_Foxo1_Pa1_Pd0_pUb0

125017
type: LocalParameter
value: 0.0181818181818

124993
type: SpeciesReference
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124981
type: SpeciesReference
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species: 123301

130028
type: Reaction
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product: 130052
reactant: 130040
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name: conversion of dnabound_Foxo1_Pa1_Pd1_pUb0 to dnabound_Foxo1_Pa1_Pd0_pUb0 by PP2A

130088
type: LocalParameter
value: 5.0E-5

130052
type: SpeciesReference
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species: 123325

130040
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species: 123397

123929
type: Reaction
kinetic law: 123977
modifier: 123965
product: 123953
reactant: 123941
fast: false
reversible: false
name: Synthesis

123989
type: LocalParameter
value: 0.0055

123638
type: Species
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initial concentration: NaN
initial amount: 100.0
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123953
type: SpeciesReference
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123941
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127099
type: Reaction
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name: conversion of nucleus_Foxo1_Pa0_Pd0_pUb1 to nucleus_Foxo1_Pa1_Pd0_pUb1 by SGK

127159
type: LocalParameter
value: 5.0E-5

127123
type: SpeciesReference
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species: 123349

127111
type: SpeciesReference
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species: 123203

129087
type: Reaction
kinetic law: 129135
modifier: 129123
product: 129111
reactant: 129099
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name: conversion of nucleus_Foxo1_Pa0_Pd1_pUb0 to nucleus_Foxo1_Pa0_Pd0_pUb0 by PP2A

129147
type: LocalParameter
value: 5.0E-5

129111
type: SpeciesReference
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species: 123165

129099
type: SpeciesReference
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species: 123241

133218
type: Reaction
kinetic law: 133254
product: 133242
reactant: 133230
fast: false
reversible: false
name: degradation of Sod2 protein

133266
type: LocalParameter
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133242
type: SpeciesReference
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species: 123129

133230
type: SpeciesReference
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species: 123626

132282
type: Reaction
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modifier: 132319
product: 132306
reactant: 132294
fast: false
reversible: false
name: transcription of sod2 by dnabound_Foxo1_Pa1_Pd0_pUb1

132343
type: LocalParameter
value: 0.3

132306
type: SpeciesReference
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132294
type: SpeciesReference
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species: 123129

123469
type: Species
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initial concentration: NaN
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in compartment: 123069

123033
type: SBMLUnit
exponent: 1.0
scale: 0
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124061
type: Reaction
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fast: false
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name: transport nucleus_Foxo1_Pa0_Pd0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_pUb0

124110
type: LocalParameter
value: 0.055

124086
type: SpeciesReference
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species: 123153

124073
type: SpeciesReference
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species: 123165

127980
type: Reaction
kinetic law: 128033
modifier: 128020
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fast: false
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name: conversion of nucleus_Foxo1_Pa1_Pd0_pUb1 to nucleus_Foxo1_Pa0_Pd0_pUb1 by PP2A

128046
type: LocalParameter
value: 5.0E-5

128007
type: SpeciesReference
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species: 123203

127994
type: SpeciesReference
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species: 123349

126518
type: Reaction
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product: 126542
reactant: 126530
fast: false
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name: conversion of dnabound_Foxo1_Pa0_Pd1_pUb0 to dnabound_Foxo1_Pa1_Pd1_pUb0 by Akt

126579
type: LocalParameter
value: 5.0E-5

126542
type: SpeciesReference
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species: 123397

126530
type: SpeciesReference
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species: 123253

128059
type: Reaction
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product: 128085
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fast: false
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name: conversion of dnabound_Foxo1_Pa1_Pd0_pUb1 to dnabound_Foxo1_Pa0_Pd0_pUb1 by PP2A

128124
type: LocalParameter
value: 5.0E-5

128085
type: SpeciesReference
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species: 123216

128072
type: SpeciesReference
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species: 123361

129955
type: Reaction
kinetic law: 130003
modifier: 129991
product: 129979
reactant: 129967
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd1_pUb0 to nucleus_Foxo1_Pa1_Pd0_pUb0 by PP2A

130015
type: LocalParameter
value: 5.0E-5

129979
type: SpeciesReference
stoichiometry: 1.0
species: 123313

129967
type: SpeciesReference
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species: 123385

131773
type: Reaction
kinetic law: 131821
modifier: 131809
product: 131797
reactant: 131785
fast: false
reversible: false
name: transcription of inr by dnabound_Foxo1_Pa0_Pd1_pUb0

131833
type: LocalParameter
value: 0.3

131797
type: SpeciesReference
stoichiometry: 1.0
species: 123566

131785
type: SpeciesReference
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species: 123129

124547
type: Reaction
kinetic law: 124583
product: 124571
reactant: 124559
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_pUb0

124595
type: LocalParameter
value: 0.55

124571
type: SpeciesReference
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species: 123228

124559
type: SpeciesReference
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species: 123241

125331
type: Reaction
kinetic law: 125367
product: 125355
reactant: 125343
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd0_pUb1 to dnabound_Foxo1_Pa1_Pd0_pUb1

125379
type: LocalParameter
value: 0.125

125355
type: SpeciesReference
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species: 123361

125343
type: SpeciesReference
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species: 123349

133023
type: Reaction
kinetic law: 133060
product: 133048
reactant: 133036
fast: false
reversible: false
name: export of sod2 RNA

133072
type: LocalParameter
value: 0.22

133048
type: SpeciesReference
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species: 123614

133036
type: SpeciesReference
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species: 123602

130608
type: Reaction
kinetic law: 130657
modifier: 130645
product: 130633
reactant: 130621
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_pUb0 to nucleus_Foxo1_Pa0_Pd1_pUb1 by SCF

130669
type: LocalParameter
value: 2.2E-5

130633
type: SpeciesReference
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species: 123277

130621
type: SpeciesReference
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species: 123241

124727
type: Reaction
kinetic law: 124763
product: 124751
reactant: 124739
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa0_Pd1_pUb1 to nucleus_Foxo1_Pa0_Pd1_pUb1

124775
type: LocalParameter
value: 0.0909090909091

124751
type: SpeciesReference
stoichiometry: 1.0
species: 123277

124739
type: SpeciesReference
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species: 123265

129159
type: Reaction
kinetic law: 129208
modifier: 129196
product: 129184
reactant: 129172
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_pUb0 to dnabound_Foxo1_Pa0_Pd0_pUb0 by PP2A

129220
type: LocalParameter
value: 5.0E-5

129184
type: SpeciesReference
stoichiometry: 1.0
species: 123177

129172
type: SpeciesReference
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species: 123253

129667
type: Reaction
kinetic law: 129715
modifier: 129703
product: 129691
reactant: 129679
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_pUb1 by IKKb

129727
type: LocalParameter
value: 5.0E-5

129691
type: SpeciesReference
stoichiometry: 1.0
species: 123409

129679
type: SpeciesReference
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species: 123337

130173
type: Reaction
kinetic law: 130221
modifier: 130209
product: 130197
reactant: 130185
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd1_pUb1 to nucleus_Foxo1_Pa1_Pd0_pUb1 by PP2A

130233
type: LocalParameter
value: 5.0E-5

130197
type: SpeciesReference
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species: 123349

130185
type: SpeciesReference
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species: 123421

132356
type: Reaction
kinetic law: 132405
modifier: 132393
product: 132381
reactant: 132369
fast: false
reversible: false
name: transcription of inr by dnabound_Foxo1_Pa1_Pd1_pUb0

132418
type: LocalParameter
value: 0.3

132381
type: SpeciesReference
stoichiometry: 1.0
species: 123566

132369
type: SpeciesReference
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species: 123129

124184
type: Reaction
kinetic law: 124220
product: 124208
reactant: 124196
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa0_Pd0_pUb0 to nucleus_Foxo1_Pa0_Pd0_pUb0

124232
type: LocalParameter
value: 0.125

124208
type: SpeciesReference
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species: 123165

124196
type: SpeciesReference
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species: 123177

132902
type: Reaction
kinetic law: 132938
product: 132926
reactant: 132914
fast: false
reversible: false
name: degradation of Inr protein

132950
type: LocalParameter
value: 0.0019

132926
type: SpeciesReference
stoichiometry: 1.0
species: 123129

132914
type: SpeciesReference
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species: 123590

123057
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

130973
type: Reaction
kinetic law: 131023
modifier: 131011
product: 130998
reactant: 130986
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_pUb1 by SCF

131035
type: LocalParameter
value: 6.6E-5

130998
type: SpeciesReference
stoichiometry: 1.0
species: 123409

130986
type: SpeciesReference
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species: 123373

125936
type: Reaction
kinetic law: 125985
modifier: 125973
product: 125960
reactant: 125948
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_pUb0 by Akt

125997
type: LocalParameter
value: 5.0E-5

125960
type: SpeciesReference
stoichiometry: 1.0
species: 123301

125948
type: SpeciesReference
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species: 123153

128870
type: Reaction
kinetic law: 128918
modifier: 128906
product: 128894
reactant: 128882
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd0_pUb1 to nucleus_Foxo1_Pa0_Pd1_pUb1 by IKKb

128930
type: LocalParameter
value: 5.0E-5

128894
type: SpeciesReference
stoichiometry: 1.0
species: 123277

128882
type: SpeciesReference
stoichiometry: 1.0
species: 123203

123493
type: Species
constant: false
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has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123069

132209
type: Reaction
kinetic law: 132258
modifier: 132246
product: 132234
reactant: 132222
fast: false
reversible: false
name: transcription of inr by dnabound_Foxo1_Pa1_Pd0_pUb1

132270
type: LocalParameter
value: 0.3

132234
type: SpeciesReference
stoichiometry: 1.0
species: 123566

132222
type: SpeciesReference
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species: 123129

131919
type: Reaction
kinetic law: 131967
modifier: 131955
product: 131943
reactant: 131931
fast: false
reversible: false
name: transcription of inr by dnabound_Foxo1_Pa0_Pd1_pUb1

131980
type: LocalParameter
value: 0.3

131943
type: SpeciesReference
stoichiometry: 1.0
species: 123566

131931
type: SpeciesReference
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species: 123129

128215
type: Reaction
kinetic law: 128266
modifier: 128254
product: 128241
reactant: 128228
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd1_pUb0 to nucleus_Foxo1_Pa0_Pd1_pUb0 by PP2A

128278
type: LocalParameter
value: 5.0E-5

128241
type: SpeciesReference
stoichiometry: 1.0
species: 123241

128228
type: SpeciesReference
stoichiometry: 1.0
species: 123385

127244
type: Reaction
kinetic law: 127293
modifier: 127281
product: 127268
reactant: 127256
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_pUb0 by SGK

127305
type: LocalParameter
value: 5.0E-5

127268
type: SpeciesReference
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species: 123373

127256
type: SpeciesReference
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species: 123228

126809
type: Reaction
kinetic law: 126857
modifier: 126845
product: 126833
reactant: 126821
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_pUb0 by SGK

126869
type: LocalParameter
value: 5.0E-5

126833
type: SpeciesReference
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species: 123301

126821
type: SpeciesReference
stoichiometry: 1.0
species: 123153

126737
type: Reaction
kinetic law: 126785
modifier: 126773
product: 126761
reactant: 126749
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd1_pUb1 to dnabound_Foxo1_Pa1_Pd1_pUb1 by Akt

126797
type: LocalParameter
value: 5.0E-5

126761
type: SpeciesReference
stoichiometry: 1.0
species: 123433

126749
type: SpeciesReference
stoichiometry: 1.0
species: 123289

123481
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123069

128137
type: Reaction
kinetic law: 128189
modifier: 128176
product: 128163
reactant: 128150
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_pUb0 by PP2A

128202
type: LocalParameter
value: 5.0E-5

128163
type: SpeciesReference
stoichiometry: 1.0
species: 123228

128150
type: SpeciesReference
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species: 123373

125755
type: Reaction
kinetic law: 125791
product: 125779
reactant: 125767
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_pUb1

125803
type: LocalParameter
value: 5.5

125779
type: SpeciesReference
stoichiometry: 1.0
species: 123409

125767
type: SpeciesReference
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species: 123421

131846
type: Reaction
kinetic law: 131895
modifier: 131882
product: 131869
reactant: 131857
fast: false
reversible: false
name: transcription of sod2 by dnabound_Foxo1_Pa0_Pd1_pUb0

131906
type: LocalParameter
value: 0.3

131869
type: SpeciesReference
stoichiometry: 1.0
species: 123602

131857
type: SpeciesReference
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species: 123129

130536
type: Reaction
kinetic law: 130584
modifier: 130572
product: 130560
reactant: 130548
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_pUb1 by SCF

130596
type: LocalParameter
value: 2.2E-5

130560
type: SpeciesReference
stoichiometry: 1.0
species: 123265

130548
type: SpeciesReference
stoichiometry: 1.0
species: 123228

125452
type: Reaction
kinetic law: 125488
product: 125476
reactant: 125464
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa1_Pd1_pUb0 to nucleus_Foxo1_Pa1_Pd1_pUb0

125500
type: LocalParameter
value: 0.00909090909091

125476
type: SpeciesReference
stoichiometry: 1.0
species: 123385

125464
type: SpeciesReference
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species: 123373

130754
type: Reaction
kinetic law: 130803
modifier: 130791
product: 130778
reactant: 130766
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_pUb1 by SCF

130815
type: LocalParameter
value: 3.0E-6

130778
type: SpeciesReference
stoichiometry: 1.0
species: 123337

130766
type: SpeciesReference
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species: 123301

129306
type: Reaction
kinetic law: 129354
modifier: 129342
product: 129330
reactant: 129318
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_pUb1 to nucleus_Foxo1_Pa0_Pd0_pUb1 by PP2A

129366
type: LocalParameter
value: 5.0E-5

129330
type: SpeciesReference
stoichiometry: 1.0
species: 123203

129318
type: SpeciesReference
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species: 123277

131119
type: Reaction
kinetic law: 131167
modifier: 131155
product: 131143
reactant: 131131
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd1_pUb0 to dnabound_Foxo1_Pa1_Pd1_pUb1 by SCF

131180
type: LocalParameter
value: 6.6E-5

131143
type: SpeciesReference
stoichiometry: 1.0
species: 123433

131131
type: SpeciesReference
stoichiometry: 1.0
species: 123397

128798
type: Reaction
kinetic law: 128846
modifier: 128834
product: 128822
reactant: 128810
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd0_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_pUb1 by IKKb

128858
type: LocalParameter
value: 5.0E-5

128822
type: SpeciesReference
stoichiometry: 1.0
species: 123265

128810
type: SpeciesReference
stoichiometry: 1.0
species: 123190

132709
type: Reaction
kinetic law: 132745
product: 132733
reactant: 132721
fast: false
reversible: false
name: export of inr RNA

132757
type: LocalParameter
value: 0.22

132733
type: SpeciesReference
stoichiometry: 1.0
species: 123578

132721
type: SpeciesReference
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species: 123566

132503
type: Reaction
kinetic law: 132552
modifier: 132539
product: 132527
reactant: 132515
fast: false
reversible: false
name: transcription of inr by dnabound_Foxo1_Pa1_Pd1_pUb1

132564
type: LocalParameter
value: 0.3

132527
type: SpeciesReference
stoichiometry: 1.0
species: 123566

132515
type: SpeciesReference
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species: 123129

131992
type: Reaction
kinetic law: 132041
modifier: 132029
product: 132017
reactant: 132005
fast: false
reversible: false
name: transcription of sod2 by dnabound_Foxo1_Pa0_Pd1_pUb1

132053
type: LocalParameter
value: 0.3

132017
type: SpeciesReference
stoichiometry: 1.0
species: 123602

132005
type: SpeciesReference
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species: 123129

129811
type: Reaction
kinetic law: 129859
modifier: 129847
product: 129835
reactant: 129823
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd0_pUb1 to dnabound_Foxo1_Pa1_Pd1_pUb1 by IKKb

129871
type: LocalParameter
value: 5.0E-5

129835
type: SpeciesReference
stoichiometry: 1.0
species: 123433

129823
type: SpeciesReference
stoichiometry: 1.0
species: 123361

128363
type: Reaction
kinetic law: 128411
modifier: 128399
product: 128387
reactant: 128375
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_pUb1 by PP2A

128423
type: LocalParameter
value: 5.0E-5

128387
type: SpeciesReference
stoichiometry: 1.0
species: 123265

128375
type: SpeciesReference
stoichiometry: 1.0
species: 123409

126083
type: Reaction
kinetic law: 126131
modifier: 126119
product: 126107
reactant: 126095
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_pUb0 to dnabound_Foxo1_Pa1_Pd0_pUb0 by Akt

126143
type: LocalParameter
value: 5.0E-5

126107
type: SpeciesReference
stoichiometry: 1.0
species: 123325

126095
type: SpeciesReference
stoichiometry: 1.0
species: 123177

124426
type: Reaction
kinetic law: 124462
product: 124450
reactant: 124438
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa0_Pd0_pUb1 to nucleus_Foxo1_Pa0_Pd0_pUb1

124474
type: LocalParameter
value: 0.125

124450
type: SpeciesReference
stoichiometry: 1.0
species: 123203

124438
type: SpeciesReference
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species: 123216

125210
type: Reaction
kinetic law: 125246
product: 125234
reactant: 125222
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa1_Pd0_pUb1 to nucleus_Foxo1_Pa1_Pd0_pUb1

125258
type: LocalParameter
value: 0.0181818181818

125234
type: SpeciesReference
stoichiometry: 1.0
species: 123349

125222
type: SpeciesReference
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species: 123337

130901
type: Reaction
kinetic law: 130949
modifier: 130937
product: 130925
reactant: 130913
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa1_Pd0_pUb0 to dnabound_Foxo1_Pa1_Pd0_pUb1 by SCF

130961
type: LocalParameter
value: 3.0E-6

130925
type: SpeciesReference
stoichiometry: 1.0
species: 123361

130913
type: SpeciesReference
stoichiometry: 1.0
species: 123325

123686
type: Species
constant: false
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has only substance units: true
initial concentration: NaN
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in compartment: 123093

126301
type: Reaction
kinetic law: 126349
modifier: 126337
product: 126325
reactant: 126313
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_pUb1 to dnabound_Foxo1_Pa1_Pd0_pUb1 by Akt

126361
type: LocalParameter
value: 5.0E-5

126325
type: SpeciesReference
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species: 123361

126313
type: SpeciesReference
stoichiometry: 1.0
species: 123216

130827
type: Reaction
kinetic law: 130876
modifier: 130864
product: 130852
reactant: 130840
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa1_Pd0_pUb0 to nucleus_Foxo1_Pa1_Pd0_pUb1 by SCF

130889
type: LocalParameter
value: 3.0E-6

130852
type: SpeciesReference
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species: 123349

130840
type: SpeciesReference
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species: 123313

131556
type: Reaction
kinetic law: 131604
modifier: 131592
product: 131580
reactant: 131568
fast: false
reversible: false
name: transcription of sod2 by dnabound_Foxo1_Pa0_Pd0_pUb0

131616
type: LocalParameter
value: 0.3

131580
type: SpeciesReference
stoichiometry: 1.0
species: 123602

131568
type: SpeciesReference
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species: 123129

123674
type: Species
constant: false
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has only substance units: true
initial concentration: NaN
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in compartment: 123093

125876
type: Reaction
kinetic law: 125912
product: 125900
reactant: 125888
fast: false
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name: transport dnabound_Foxo1_Pa1_Pd1_pUb1 to nucleus_Foxo1_Pa1_Pd1_pUb1

125924
type: LocalParameter
value: 0.125

125900
type: SpeciesReference
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species: 123421

125888
type: SpeciesReference
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species: 123433

125815
type: Reaction
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product: 125840
reactant: 125827
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd1_pUb1 to dnabound_Foxo1_Pa1_Pd1_pUb1

125864
type: LocalParameter
value: 0.125

125840
type: SpeciesReference
stoichiometry: 1.0
species: 123433

125827
type: SpeciesReference
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species: 123421

130100
type: Reaction
kinetic law: 130149
modifier: 130137
product: 130125
reactant: 130113
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_pUb1 by PP2A

130161
type: LocalParameter
value: 5.0E-5

130125
type: SpeciesReference
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species: 123337

130113
type: SpeciesReference
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species: 123409

124787
type: Reaction
kinetic law: 124823
product: 124811
reactant: 124799
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd1_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_pUb1

124835
type: LocalParameter
value: 0.55

124811
type: SpeciesReference
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species: 123265

124799
type: SpeciesReference
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species: 123277

123457
type: Species
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has only substance units: true
initial concentration: NaN
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in compartment: 123069

125090
type: Reaction
kinetic law: 125126
product: 125114
reactant: 125102
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd0_pUb0 to dnabound_Foxo1_Pa1_Pd0_pUb0

125138
type: LocalParameter
value: 0.125

125114
type: SpeciesReference
stoichiometry: 1.0
species: 123325

125102
type: SpeciesReference
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species: 123313

123736
type: Species
constant: false
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has only substance units: true
initial concentration: NaN
initial amount: 10.0
in compartment: 123093

126664
type: Reaction
kinetic law: 126713
modifier: 126700
product: 126688
reactant: 126676
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_pUb1 to nucleus_Foxo1_Pa1_Pd1_pUb1 by Akt

126725
type: LocalParameter
value: 5.0E-5

126688
type: SpeciesReference
stoichiometry: 1.0
species: 123421

126676
type: SpeciesReference
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species: 123277

127171
type: Reaction
kinetic law: 127220
modifier: 127207
product: 127195
reactant: 127183
fast: false
reversible: false
name: conversion of dnabound_Foxo1_Pa0_Pd0_pUb1 to dnabound_Foxo1_Pa1_Pd0_pUb1 by SGK

127232
type: LocalParameter
value: 5.0E-5

127195
type: SpeciesReference
stoichiometry: 1.0
species: 123361

127183
type: SpeciesReference
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species: 123216

124244
type: Reaction
kinetic law: 124282
product: 124269
reactant: 124256
fast: false
reversible: false
name: transport cytoplasm_Foxo1_Pa0_Pd0_pUb1 to nucleus_Foxo1_Pa0_Pd0_pUb1

124294
type: LocalParameter
value: 0.181818181818

124269
type: SpeciesReference
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species: 123203

124256
type: SpeciesReference
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species: 123190

125029
type: Reaction
kinetic law: 125065
product: 125053
reactant: 125041
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa1_Pd0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_pUb0

125077
type: LocalParameter
value: 0.55

125053
type: SpeciesReference
stoichiometry: 1.0
species: 123301

125041
type: SpeciesReference
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species: 123313

127463
type: Reaction
kinetic law: 127512
modifier: 127499
product: 127487
reactant: 127475
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa0_Pd1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_pUb1 by SGK

127524
type: LocalParameter
value: 5.0E-5

127487
type: SpeciesReference
stoichiometry: 1.0
species: 123409

127475
type: SpeciesReference
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species: 123265

124607
type: Reaction
kinetic law: 124643
product: 124631
reactant: 124619
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd1_pUb0 to dnabound_Foxo1_Pa0_Pd1_pUb0

124655
type: LocalParameter
value: 0.25

124631
type: SpeciesReference
stoichiometry: 1.0
species: 123253

124619
type: SpeciesReference
stoichiometry: 1.0
species: 123241

124366
type: Reaction
kinetic law: 124402
product: 124390
reactant: 124378
fast: false
reversible: false
name: transport nucleus_Foxo1_Pa0_Pd0_pUb1 to dnabound_Foxo1_Pa0_Pd0_pUb1

124414
type: LocalParameter
value: 0.25

124390
type: SpeciesReference
stoichiometry: 1.0
species: 123216

124378
type: SpeciesReference
stoichiometry: 1.0
species: 123203

123772
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 1000.0
in compartment: 123093

126445
type: Reaction
kinetic law: 126493
modifier: 126481
product: 126469
reactant: 126457
fast: false
reversible: false
name: conversion of nucleus_Foxo1_Pa0_Pd1_pUb0 to nucleus_Foxo1_Pa1_Pd1_pUb0 by Akt

126505
type: LocalParameter
value: 5.0E-5

126469
type: SpeciesReference
stoichiometry: 1.0
species: 123385

126457
type: SpeciesReference
stoichiometry: 1.0
species: 123241

129883
type: Reaction
kinetic law: 129931
modifier: 129919
product: 129907
reactant: 129895
fast: false
reversible: false
name: conversion of cytoplasm_Foxo1_Pa1_Pd1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_pUb0 by PP2A

129943
type: LocalParameter
value: 5.0E-5

129907
type: SpeciesReference
stoichiometry: 1.0
species: 123301

129895
type: SpeciesReference
stoichiometry: 1.0
species: 123373

125391
type: Reaction
kinetic law: 125427
product: 125415
reactant: 125403
fast: false
reversible: false
name: transport dnabound_Foxo1_Pa1_Pd0_pUb1 to nucleus_Foxo1_Pa1_Pd0_pUb1

125439
type: LocalParameter
value: 0.125

125415
type: SpeciesReference
stoichiometry: 1.0
species: 123349

125403
type: SpeciesReference
stoichiometry: 1.0
species: 123361

123760
type: Species
constant: false
boundary condition: false
has only substance units: true
initial concentration: NaN
initial amount: 0.0
in compartment: 123093

131483
type: Reaction
kinetic law: 131532
modifier: 131520
product: 131508
reactant: 131495
fast: false
reversible: false
name: transcription of inr by dnabound_Foxo1_Pa0_Pd0_pUb0

131544
type: LocalParameter
value: 0.3

131508
type: SpeciesReference
stoichiometry: 1.0
species: 123566

131495
type: SpeciesReference
stoichiometry: 1.0
species: 123129