MODEL1112110002
type: SBMLModel
parameter: COPASI6
name: Farhy2009_GlucagonCounterRegulationModel
parameter: COPASI12
parameter: COPASI11
parameter: COPASI9
parameter: COPASI14
parameter: 048015
parameter: 048099
time units: 687647
parameter: COPASI7
rule: 048195
rule: 048147
rule: 048171
volume units: MODEL1105180000#
parameter: COPASI13
rule: 048123
parameter: COPASI15
parameter: 048027
area units: 802883
parameter: 048075
parameter: COPASI4
parameter: 048003
parameter: 048087
parameter: COPASI8
parameter: 048051
parameter: COPASI10
substance units: 687672
curated: false
species: COPASI3
compartment: 047991
notes: This a model from the article: Pancreatic network control of glucagon secretion and counterregulation. Farhy LS, McCall AL. Methods Enzymol. 2009;467:547-81. 19897107 , Abstract: Glucagon counterregulation (GCR) is a key protection against hypoglycemia compromised in insulinopenic diabetes by an unknown mechanism. In this work, we present an interdisciplinary approach to the analysis of the GCR control mechanisms. Our results indicate that a pancreatic network which unifies a few explicit interactions between the major islet peptides and blood glucose (BG) can replicate the normal GCR axis and explain its impairment in diabetes. A key and novel component of this network is an alpha-cell auto-feedback, which drives glucagon pulsatility and mediates triggering of pulsatile GCR by hypoglycemia via a switch-off of the beta-cell suppression of the alpha-cells. We have performed simulations based on our models of the endocrine pancreas which explain the in vivo GCR response to hypoglycemia of the normal pancreas and the enhancement of defective pulsatile GCR in beta-cell deficiency by switch-off of intrapancreatic alpha-cell suppressing signals. The models also predicted that reduced insulin secretion decreases and delays the GCR. In conclusion, based on experimental data we have developed and validated a model of the normal GCR control mechanisms and their dysregulation in insulin deficient diabetes. One advantage of this construct is that all model components are clinically measurable, thereby permitting its transfer, validation, and application to the study of the GCR abnormalities of the human endocrine pancreas in vivo. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0…
parameter: COPASI5
rule: 048159
rule: 048183
rule: 048135
parameter: 048039
length unit: 802859
is described by: http://identifiers.org/pubmed/19897107
parameter: 048063
rule: 048111
species: COPASI2

COPASI6
type: Parameter
constant: true
value: 85.0
name: tGl

COPASI12
type: Parameter
constant: true
value: 600.0
name: bg

COPASI11
type: Parameter
constant: false
value: 110.0
name: step

COPASI9
type: Parameter
constant: false
value: 600.0
name: BG

COPASI14
type: Parameter
constant: false
value: 0.0
name: pluse2

048015
type: Parameter
constant: true
value: 2128.0
name: rGlbasal

048099
type: Parameter
constant: true
value: 7.2
name: DGL

COPASI7
type: Parameter
constant: true
value: 50.0
name: tBG

COPASI13
type: Parameter
constant: false
value: 600.0
name: bg'

COPASI15
type: Parameter
constant: false
value: 10.0
name: pluse1

048027
type: Parameter
constant: true
value: 80000.0
name: rINS

048075
type: Parameter
constant: true
value: 5.0
name: nBG

COPASI4
type: Parameter
constant: true
value: 22.0
name: kGl

048003
type: Parameter
constant: true
value: 42570.0
name: rGl

048087
type: Parameter
constant: true
value: 3.0
name: nBG2

COPASI8
type: Parameter
constant: true
value: 20.0
name: tINS

048051
type: Parameter
constant: true
value: 400.0
name: tBG2

COPASI10
type: Parameter
constant: false
value: 10.0
name: pulse

COPASI3
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 50.0
initial amount: NaN
in compartment: 047991
name: INS

047991
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: body

COPASI5
type: Parameter
constant: true
value: 14.0
name: kINS

048039
type: Parameter
constant: true
value: 270.0
name: rINSbasal

048063
type: Parameter
constant: true
value: 5.0
name: nGl

COPASI2
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 50.0
initial amount: NaN
in compartment: 047991
name: GL