MODEL1112050001
type: SBMLModel
parameter: metaid_0000089
rule: metaid_0000151
parameter: COPASI33
rule: metaid_0000128
species: COPASI11
rule: metaid_0000115
parameter: COPASI63
rule: metaid_0000131
rule: metaid_0000134
rule: metaid_0000150
species: COPASI2
parameter: COPASI49
parameter: COPASI55
rule: metaid_0000140
rule: metaid_0000114
rule: metaid_0000127
rule: metaid_0000143
parameter: metaid_0000080
rule: metaid_0000146
species: COPASI30
rule: metaid_0000120
rule: metaid_0000107
parameter: COPASI59
parameter: COPASI52
parameter: metaid_0000081
rule: metaid_0000137
parameter: COPASI56
rule: metaid_0000153
parameter: metaid_0000085
rule: metaid_0000122
rule: metaid_0000117
species: COPASI28
rule: metaid_0000136
rule: metaid_0000149
parameter: metaid_0000072
compartment: metaid_0000103
name: Liu2009_GlucoseMobilization_UptakeModel
parameter: COPASI51
parameter: COPASI32
rule: metaid_0000129
parameter: COPASI64
species: COPASI8
species: COPASI13
rule: metaid_0000119
parameter: metaid_0000093
parameter: metaid_0000076
parameter: COPASI37
rule: metaid_0000135
curated: false
species: COPASI22
rule: metaid_0000112
substance units: 687672
species: COPASI27
parameter: COPASI54
species: COPASI6
rule: metaid_0000141
parameter: metaid_0000068
parameter: metaid_0000097
rule: metaid_0000144
rule: metaid_0000105
species: COPASI16
parameter: COPASI40
rule: metaid_0000147
rule: metaid_0000121
species: COPASI19
rule: metaid_0000124
parameter: COPASI58
parameter: metaid_0000101
rule: metaid_0000111
parameter: metaid_0000084
parameter: COPASI65
parameter: COPASI44
species: COPASI21
parameter: metaid_0000090
species: COPASI5
parameter: metaid_0000088
parameter: metaid_0000069
rule: metaid_0000123
species: COPASI10

metaid_0000089
type: Parameter
constant: true
value: 1162.0
name: C1

COPASI33
type: Parameter
constant: false
value: 9.09090909090909
name: AP

COPASI11
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: metaid_0000103
name: cell surface GLUT4

metaid_0000103
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: cellsurface

COPASI63
type: Parameter
constant: false
value: 0.0
name: glycogen synthase activation

COPASI2
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.389E-11
initial amount: NaN
in compartment: metaid_0000103
name: plasma glucagon

COPASI49
type: Parameter
constant: true
value: 0.003
name: k18

COPASI55
type: Parameter
constant: false
value: 42.1483870967742
name: k24

metaid_0000080
type: Parameter
constant: true
value: 0.01
name: a3

COPASI30
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000104
name: liver glucose

metaid_0000104
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: intracellular

COPASI59
type: Parameter
constant: true
value: 0.167
name: k28

COPASI52
type: Parameter
constant: true
value: 1.67E-18
name: k21

metaid_0000081
type: Parameter
constant: true
value: 6.0E7
name: a4

COPASI56
type: Parameter
constant: true
value: 2.77
name: k25

metaid_0000085
type: Parameter
constant: true
value: 11.0
name: v

COPASI28
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 90.0
initial amount: NaN
in compartment: metaid_0000104
name: intracellular GLUT4

metaid_0000072
type: Parameter
constant: true
value: 50.0
name: vmax2

COPASI51
type: Parameter
constant: true
value: 2.1E-4
name: k20

COPASI32
type: Parameter
constant: true
value: 0.0151
name: b1

COPASI64
type: Parameter
constant: false
value: 2.07765458370863E-13
name: feedback gulcagon

COPASI8
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000103
name: unphosphorylated once bound receptor

COPASI13
type: Species
constant: true
boundary condition: true
has only substance units: false
initial concentration: 25.9
initial amount: NaN
in compartment: metaid_0000103
name: exogenous glucose

metaid_0000093
type: Parameter
constant: true
value: 1.85
name: q2

metaid_0000076
type: Parameter
constant: true
value: 258.0
name: vmaxp

COPASI37
type: Parameter
constant: true
value: 0.461
name: k6

COPASI22
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 99.4
initial amount: NaN
in compartment: metaid_0000104
name: PI(4,5)P2

COPASI27
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000104
name: activated PKC

COPASI54
type: Parameter
constant: true
value: 10.0
name: k23

COPASI6
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000103
name: cellular insulin

metaid_0000068
type: Parameter
constant: true
value: 1530.0
name: km3

metaid_0000097
type: Parameter
constant: true
value: 8.97E-13
name: IRp

COPASI16
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000104
name: phosphorylated once bound intracellular receptors

COPASI40
type: Parameter
constant: false
value: 0.131448692152917
name: k9

COPASI19
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-13
initial amount: NaN
in compartment: metaid_0000104
name: unactive PI3 kinase

COPASI58
type: Parameter
constant: false
value: 6.93147180559945
name: k27

metaid_0000101
type: Parameter
constant: true
value: 6.0E7
name: k2

metaid_0000084
type: Parameter
constant: true
value: 0.01
name: b3

COPASI65
type: Parameter
constant: false
value: 4.43996341192627E-12
name: insulin infusion

COPASI44
type: Parameter
constant: false
value: 0.00695833333333333
name: k13

COPASI21
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.31
initial amount: NaN
in compartment: metaid_0000104
name: PI(3,4,5)P3

metaid_0000090
type: Parameter
constant: true
value: 0.005
name: p1

COPASI5
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000103
name: glucagon receptor

metaid_0000088
type: Parameter
constant: true
value: 4.44E-12
name: Rm

metaid_0000069
type: Parameter
constant: true
value: 774.0
name: km4

COPASI10
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000103
name: phosphorylated once bound receptor

COPASI60
type: Parameter
constant: true
value: 0.001155
name: k29

COPASI31
type: Parameter
constant: false
value: 1.11111111111111E15
name: a6

COPASI15
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000104
name: phosphorylated twice bound intracellular receptor

COPASI18
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000104
name: phosphorylated IRS1

metaid_0000102
type: Parameter
constant: true
value: 2500.0
name: k3

metaid_0000091
type: Parameter
constant: true
value: 0.01594
name: p2

COPASI50
type: Parameter
constant: true
value: 0.0021
name: k19

COPASI35
type: Parameter
constant: false
value: 3.33333333333333E-4
name: k4

metaid_0000077
type: Parameter
constant: true
value: 9.0E-13
name: R0

COPASI20
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000104
name: IRS1-PI3 Kinase complex

COPASI36
type: Parameter
constant: false
value: 1.002E-16
name: k5

COPASI24
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000104
name: inactive PKB

metaid_0000067
type: Parameter
constant: true
value: 15300.0
name: km2

COPASI61
type: Parameter
constant: false
value: 0.0
name: effect

metaid_0000092
type: Parameter
constant: true
value: 10.0
name: q1

metaid_0000100
type: Parameter
constant: true
value: 6.0E7
name: k1

COPASI7
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 9.0E-13
initial amount: NaN
in compartment: metaid_0000103
name: unbound insulin receptors

metaid_0000083
type: Parameter
constant: true
value: 0.002
name: b2

metaid_0000078
type: Parameter
constant: true
value: 0.12
name: a1

COPASI62
type: Parameter
constant: false
value: 0.0
name: Ig4

metaid_0000087
type: Parameter
constant: true
value: 2.23E-10
name: Gm

COPASI48
type: Parameter
constant: true
value: 0.2
name: k17

metaid_0000094
type: Parameter
constant: true
value: 1.0
name: PTP

COPASI12
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1935.0
initial amount: NaN
in compartment: metaid_0000103
name: plasma glucose

metaid_0000073
type: Parameter
constant: true
value: 10.0
name: vmax3

metaid_0000079
type: Parameter
constant: true
value: 0.3
name: a2

W3 CDTF: Mon Dec 05 13:40:06 GMT 2011

COPASI34
type: Parameter
constant: false
value: 0.131448692152917
name: k9bas

metaid_0000098
type: Parameter
constant: true
value: 5.0E-15
name: PI3K

COPASI26
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 100.0
initial amount: NaN
in compartment: metaid_0000104
name: inactivated PKC

COPASI29
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 200.0
initial amount: NaN
in compartment: metaid_0000104
name: liver glucagon

metaid_0000095
type: Parameter
constant: true
value: 1.0
name: PTEN

COPASI41
type: Parameter
constant: false
value: 2.96103448275862
name: k10

metaid_0000070
type: Parameter
constant: true
value: 67.0
name: kms

COPASI39
type: Parameter
constant: false
value: 7.06464146944542E12
name: k8

W3 CDTF: Mon Dec 05 13:40:46 GMT 2011

metaid_0000099
type: Parameter
constant: true
value: 1.39
name: k9sim

COPASI45
type: Parameter
constant: false
value: 0.0011088
name: k14

metaid_0000074
type: Parameter
constant: true
value: 4.0
name: vmax4

COPASI42
type: Parameter
constant: false
value: 0.0
name: k11

metaid_0000071
type: Parameter
constant: true
value: 600.0
name: kmp

COPASI4
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000103
name: cellular glucagon

COPASI25
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000104
name: activated PKB

COPASI9
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000103
name: phosphorylated twice bound receptor

metaid_0000096
type: Parameter
constant: true
value: 1.0
name: SHIP

COPASI14
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-13
initial amount: NaN
in compartment: metaid_0000104
name: unbound unphosphorylated receptor

COPASI46
type: Parameter
constant: true
value: 0.2
name: k15

metaid_0000075
type: Parameter
constant: true
value: 28.4
name: vmaxs

COPASI23
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 0.29
initial amount: NaN
in compartment: metaid_0000104
name: PI(3,4)P2

COPASI53
type: Parameter
constant: false
value: 1.39597315436242
name: k22

metaid_0000082
type: Parameter
constant: true
value: 0.2
name: a5

COPASI17
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 1.0E-12
initial amount: NaN
in compartment: metaid_0000104
name: unphosphorylated IRS1

COPASI43
type: Parameter
constant: false
value: 0.0
name: k12

COPASI57
type: Parameter
constant: false
value: 6.93147180559945
name: k26

ORG:
  orgname: EMBL-EBI
n:
  given: Ishan
  family: Ajmera

metaid_0000086
type: Parameter
constant: true
value: 3.0
name: vp

COPASI3
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: 5.38E-10
initial amount: NaN
in compartment: metaid_0000103
name: plasma insulin

COPASI47
type: Parameter
constant: true
value: 20.0
name: k16

COPASI38
type: Parameter
constant: true
value: 4.16
name: k7

ORG:
  orgname: EMBL-EBI
n:
  given: Ishan
  family: Ajmera

ORG:
  orgname: EMBL-EBI
n:
  given: Ishan
  family: Ajmera

W3 CDTF: Mon Dec 05 13:40:46 GMT 2011

W3 CDTF: Mon Dec 05 13:40:46 GMT 2011