(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
(3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate
2-(alpha-Hydroxyethyl)thiamine diphosphate
2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate
(3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
Glycoprotein with the oligosaccharide chain attached by N-glycosyllinkage to protein L-asparagine
trans,trans,cis-Geranylgeranyl diphosphate
(3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]S-(2-methylpropanoyl)dihydrolipoyllysine
(3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
[Dihydrolipoyllysine-residue succinyltransferase]S-succinyldihydrolipoyllysine
p-aminobenzoate-beta-D-glucopyranosyl ester
1-Hydroxy-2-methyl-2-butenyl 4-diphosphate
[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]S-(3-methylbutanoyl)dihydrolipoyllysine
1-Phosphatidyl-1D-myo-inositol 3-phosphate
This model is from the article: Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis. Huthmacher C, Hoppe A, Bulik S, Holzhütter HG. BMC Syst Biol. 2010 Aug 31;4:120. 20807400 , Abstract: BACKGROUND: Despite enormous efforts to combat malaria the disease still afflicts up to half a billion people each year of which more than one million die. Currently no approved vaccine is available and resistances to antimalarials are widely spread. Hence, new antimalarial drugs are urgently needed. RESULTS: Here, we present a computational analysis of the metabolism of Plasmodium falciparum, the deadliest malaria pathogen. We assembled a compartmentalized metabolic model and predicted life cycle stage specific metabolism with the help of a flux balance approach that integrates gene expression data. Predicted metabolite exchanges between parasite and host were found to be in good accordance with experimental findings when the parasite's metabolic network was embedded into that of its host (erythrocyte). Knock-out simulations identified 307 indispensable metabolic reactions within the parasite. 35 out of 57 experimentally demonstrated essential enzymes were recovered and another 16 enzymes, if additionally the assumption was made that nutrient uptake from the host cell is limited and all reactions catalyzed by the inhibited enzyme are blocked. This predicted set of putative drug targets, shown to be enriched with true targets by a factor of at least 2.75, was further analyzed with respect to homology to human enzymes, functional similarity to therapeutic targets in other organisms and their predicted potency for prophylaxis and disease treatment. CONCLUSIONS: The results suggest that the set of essential enzymes predicted by our flux balance approach represents a promising starting point for further drug development. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
Protein C-terminal S-farnesyl-L-cysteine
Guanosine 3'-diphosphate 5'-triphosphate
1-Phosphatidyl-1D-myo-inositol 4-phosphate
[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]S-(2-methylbutanoyl)dihydrolipoyllysine
4-carboxy-1-hydroxybutylthiamine diphosphate
2-methyl-1-hydroxybutylthiamine diphosphate
5,10-methylenetetrahydrofolate polyglutamate
[Dihydrolipoyllysine-residue acetyltransferase]S-acetyldihydrolipoyllysine
Formamidopyrimidine nucleoside triphosphate
Protein C-terminal S-farnesyl-L-cysteine methyl ester
2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol
N-Acetyl-alpha-D-glucosamine 1-phosphate
3-methyl-1-hydroxybutylthiamine diphosphate
Protein N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine
2-C-Methyl-D-erythritol 2,4-cyclodiphosphate
2,5-Diaminopyrimidine nucleoside triphosphate
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate